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Search of human proteins with 24025688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
(690 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 1409 0.0
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 645 0.0
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 484 e-136
gi|148746189 multiple PDZ domain protein [Homo sapiens] 223 5e-58
gi|112382257 InaD-like [Homo sapiens] 189 1e-47
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 113 5e-25
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 111 3e-24
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 110 4e-24
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 110 6e-24
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 108 2e-23
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 108 2e-23
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 92 1e-18
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 92 1e-18
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 92 1e-18
gi|45827729 scribble isoform b [Homo sapiens] 92 1e-18
gi|45827731 scribble isoform a [Homo sapiens] 92 1e-18
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 86 9e-17
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 86 9e-17
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 86 9e-17
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 86 9e-17
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 85 2e-16
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 85 2e-16
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 84 6e-16
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 84 6e-16
gi|87196343 PDZ domain containing 2 [Homo sapiens] 83 7e-16
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 81 3e-15
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 81 3e-15
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 81 3e-15
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 79 1e-14
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 79 1e-14
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 1409 bits (3646), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQP 60
MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQP
Sbjct: 1 MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQP 60
Query: 61 LDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVC 120
LDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVC
Sbjct: 61 LDTPCGHTFCYKCLRNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVC 120
Query: 121 KDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADC 180
KDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADC
Sbjct: 121 KDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADC 180
Query: 181 LGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSN 240
LGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSN
Sbjct: 181 LGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSN 240
Query: 241 PYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR 300
PYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR
Sbjct: 241 PYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR 300
Query: 301 AVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTD 360
AVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTD
Sbjct: 301 AVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTD 360
Query: 361 EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR
Sbjct: 361 EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
Query: 421 PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG 480
PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG
Sbjct: 421 PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG 480
Query: 481 MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK
Sbjct: 481 MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
Query: 541 ASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHD 600
ASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHD
Sbjct: 541 ASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHD 600
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV
Sbjct: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
Query: 661 GMSHSALVPMLKEQRNKVTLTVICWPGSLV 690
GMSHSALVPMLKEQRNKVTLTVICWPGSLV
Sbjct: 661 GMSHSALVPMLKEQRNKVTLTVICWPGSLV 690
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 645 bits (1664), Expect = 0.0
Identities = 352/730 (48%), Positives = 468/730 (64%), Gaps = 61/730 (8%)
Query: 15 SSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCL 74
S++ PLC CGQ H ENH Y+Y EVDDDL+CHICLQ LL PLDTPCGHT+C CL
Sbjct: 6 SANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCL 65
Query: 75 RNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLK 134
NFL EKDFCP+DRK L + CKKSSILV+KLL+KLLV CPF C V+QRCDLE H +
Sbjct: 66 TNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQ 125
Query: 135 NRCPGASHRRVALERRKTSR-----------------------TQAEIENENG---PTLL 168
C GASH + +R++ S+ T + + +E G P +
Sbjct: 126 TSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYV 185
Query: 169 DPAGTLSPEADCLGTG------AVPVERHLTSAS-----------LSTWSEEPGLDNPAF 211
A P + +G A P ER + L + N A
Sbjct: 186 SSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHAD 245
Query: 212 EESAGADTTQQPLS-------LPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQE 264
+ ++ T P +P+GEIT+I+I+R +P L I +VGG+ETPL++I+IQ
Sbjct: 246 QGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQH 305
Query: 265 VYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRA 324
+YRDGVIARDGRLL GD IL+VN +ISNV HNYA +L QPC L LTV+RE++F +R
Sbjct: 306 IYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRN 365
Query: 325 HNHS-DSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSS 383
+ + D+ PR++ F V L+K EQLGIKLVR+ DEPGVFI ++L+GG+A + G+L
Sbjct: 366 NGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEE 425
Query: 384 NDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHH 443
NDRVLAINGHDL+YG+PE AA +IQAS RV+L ++R + + + +EAG +S+ S
Sbjct: 426 NDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSP 485
Query: 444 TPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPP 503
P R ++ K L +TC EK + ++K+P ESLGMTVAGG + +LPI+V SV P
Sbjct: 486 GPG---ERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 542
Query: 504 HGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQ 563
G ++RDGRIK GD+LLN++G++LT +S SEAVA+LK +++S + LKALEV+ E Q
Sbjct: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSS--IVLKALEVK--EYEPQ 598
Query: 564 NAEEQPSTFSENEYDA---SWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE 620
P+ N A WSPSWVMWL LP L++C DIVLRR+ GS GF IVGGYE
Sbjct: 599 EDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYE 658
Query: 621 ENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
E + N+PFFIK+IV GTPAY DGR++CGD+++AVNG ST GM H+ L +LKE + ++TL
Sbjct: 659 EYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
Query: 681 TVICWPGSLV 690
T++ WPG+ +
Sbjct: 719 TIVSWPGTFL 728
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 484 bits (1246), Expect = e-136
Identities = 250/469 (53%), Positives = 339/469 (72%), Gaps = 11/469 (2%)
Query: 226 LPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQ 285
+P+GEIT+I+I+R +P L I +VGG+ETPL++I+IQ +YRDGVIARDGRLL GD IL+
Sbjct: 171 IPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILK 230
Query: 286 VNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHS-DSNSPREEIFQVALHK 344
VN +ISNV HNYA +L QPC L LTV+RE++F +R + + D+ PR++ F V L+K
Sbjct: 231 VNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNK 290
Query: 345 RDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAA 404
EQLGIKLVR+ DEPGVFI ++L+GG+A + G+L NDRVLAINGHDL+YG+PE AA
Sbjct: 291 SSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAA 350
Query: 405 QIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC 464
+IQAS RV+L ++R + + + +EAG +S+ S P R ++ K L +TC
Sbjct: 351 HLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPG---ERSNTPKPLHPTITC 407
Query: 465 QEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNING 524
EK + ++K+P ESLGMTVAGG + +LPI+V SV P G ++RDGRIK GD+LLN++G
Sbjct: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467
Query: 525 IDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDA---SW 581
++LT +S SEAVA+LK +++S + LKALEV+ E Q P+ N A W
Sbjct: 468 VELTEVSRSEAVALLKRTSSS--IVLKALEVK--EYEPQEDCSSPAALDSNHNMAPPSDW 523
Query: 582 SPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641
SPSWVMWL LP L++C DIVLRR+ GS GF IVGGYEE + N+PFFIK+IV GTPAY
Sbjct: 524 SPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYN 583
Query: 642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSLV 690
DGR++CGD+++AVNG ST GM H+ L +LKE + ++TLT++ WPG+ +
Sbjct: 584 DGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 632
Score = 106 bits (264), Expect = 8e-23
Identities = 101/401 (25%), Positives = 170/401 (42%), Gaps = 67/401 (16%)
Query: 312 LTVLRERRFGNRAHNHSDSNS-------------------PREEIFQVALHKRDSGEQLG 352
L+VLR + G+ NH+D P EI + +++ D E L
Sbjct: 132 LSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLS 191
Query: 353 IKLVRRTDEPGVFIL--DLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQAS 410
I+LV ++ P V I+ + G+ A+DGRL D +L +NG D+ A ++++
Sbjct: 192 IRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQP 251
Query: 411 GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHIT 470
+ + LT+ R K S + P Y R S H+
Sbjct: 252 CQVLWLTVMREQK------------FRSRNNGQAPDAYRPRDDSF------------HVI 287
Query: 471 V-KKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
+ K P E LG+ + K E +F+ +V G R G+++ D +L ING DL
Sbjct: 288 LNKSSPEEQLGIKLV----RKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRY 343
Query: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDA--SWSPSWVM 587
S A +++AS V +V + Q + P F E +++ SWSP
Sbjct: 344 GSPESAAHLIQASER---------RVHLV-VSRQVRQRSPDIFQEAGWNSNGSWSPGPGE 393
Query: 588 WLGLPSTLH---SCHDIV--LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYD 642
P LH +CH+ V +++ S G ++ GG + P ++ ++ G D
Sbjct: 394 RSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRD 453
Query: 643 GRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
GR+K GD+++ V+G+ +S S V +LK + + L +
Sbjct: 454 GRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 494
Score = 37.0 bits (84), Expect = 0.061
Identities = 27/106 (25%), Positives = 44/106 (41%), Gaps = 18/106 (16%)
Query: 110 LLVLCPFSSVCKDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLD 169
LL++ P+ S + +L C GASH + +R++ S+
Sbjct: 5 LLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGC------------ 52
Query: 170 PAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESA 215
P+ T P +A++S ++EPGLDNPA+ SA
Sbjct: 53 ------PDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSA 92
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 223 bits (568), Expect = 5e-58
Identities = 168/513 (32%), Positives = 260/513 (50%), Gaps = 60/513 (11%)
Query: 184 GAVPVERHLTSASL---STWSEEPGLDNPAFEESAGADTTQQPLSLP--EGEITTIEIHR 238
GA E+ +S SL + S EP S A P + P G TTIEI +
Sbjct: 1575 GAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISK 1634
Query: 239 SNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNY 298
LG+SIVGG++T L I+I EVY +G +DGRL AGDQIL+VN ++ +H+
Sbjct: 1635 GRT--GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
Query: 299 ARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEI---FQVALHKRDSGEQLGIKL 355
A VL Q + LT+ R+ ++ EE+ + L K+ G+ LG+ +
Sbjct: 1693 AINVLRQTPQRVRLTLYRD-----------EAPYKEEEVCDTLTIELQKKP-GKGLGLSI 1740
Query: 356 VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQAS-GERV 414
V + ++ GVF+ D+++GG+A DGRL D++L +NG D++ T E A +++ S G
Sbjct: 1741 VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLS 1800
Query: 415 NLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKE 474
+ T G SS+S+ SS K+ + + +KK
Sbjct: 1801 SFTFPLSG--------------SSTSES-------LESSSKKNALASEIQGLRTVEMKKG 1839
Query: 475 PHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSE 534
P +SLG+++AGG GS G++PIF+ + P G A+ +++ GD ++ I G ++H++
Sbjct: 1840 PTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQ 1899
Query: 535 AVAMLKASAASPAVALKALEVQIVE----EATQNAEEQPSTFSENEYDASWSPSWVMWLG 590
AV +LK ++ S +E+Q+V +++P++ S + + S + LG
Sbjct: 1900 AVNLLKNASGS-------IEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLG 1952
Query: 591 LPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650
P C I L R G GFSIVGGY H + P ++KT+ A DGRLK GD
Sbjct: 1953 PPQ----CKSITLERGPDGL-GFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQ 2007
Query: 651 IVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
I+AVNG S G++H V +LK + VTL V+
Sbjct: 2008 IIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 119 bits (299), Expect = 7e-27
Identities = 114/491 (23%), Positives = 190/491 (38%), Gaps = 101/491 (20%)
Query: 237 HRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSH 296
H P Q G+ I E L ++I+ + GV A DGRL GDQIL V++ +
Sbjct: 1483 HLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
Query: 297 NYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSG--EQLGIK 354
++L T+ LT+ E + + + S ++ +L SG E I+
Sbjct: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602
Query: 355 LVRRTDEPGVF------------------------------------------ILDLLEG 372
R+ P +F I ++ E
Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEE 1662
Query: 373 GLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIRE 432
G A +DGRL + D++L +NG DL+ T + A +++ + +RV LT+ R P +
Sbjct: 1663 GAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV-- 1720
Query: 433 AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG 492
C I ++K+P + LG+++ G K
Sbjct: 1721 -------------------------------CDTLTIELQKKPGKGLGLSIVG----KRN 1745
Query: 493 ELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKA 552
+ +FV+ + G DGR+ +GD +L +NG D+ N + A+LK S S L +
Sbjct: 1746 DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGS----LSS 1801
Query: 553 LEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWG 612
+ +T + E S + L S + + +++ S G
Sbjct: 1802 FTFPLSGSSTSESLESSSKKN----------------ALASEIQGLRTVEMKKGPTDSLG 1845
Query: 613 FSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 672
SI GG + P FI + A +L+ GD IV + G ST GM+H+ V +LK
Sbjct: 1846 ISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905
Query: 673 EQRNKVTLTVI 683
+ + V+
Sbjct: 1906 NASGSIEMQVV 1916
Score = 117 bits (294), Expect = 3e-26
Identities = 127/490 (25%), Positives = 212/490 (43%), Gaps = 63/490 (12%)
Query: 245 LGISIVG--GNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISN-VSHNYARA 301
LG S+VG + I +QE+ V RDGRL DQIL +N + ++H A +
Sbjct: 148 LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAIS 207
Query: 302 VLSQPCNTLHLTVLRER----------RFGNRAHNHSDSNSPREEIFQVALHKRDSGEQL 351
+L + +T+ L + R R + A S ++P + + G L
Sbjct: 208 ILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGL 267
Query: 352 GIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASG 411
G ++ GV + +L GG+A Q GRL S D +L I DL + E AQ+++ G
Sbjct: 268 GFGIIGGK-ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG 326
Query: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQ-EKHIT 470
RV L IAR G + G SSS TP + + ++ + K++
Sbjct: 327 NRVKLMIAR-GAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV- 384
Query: 471 VKKEPHESLGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
+ LG+T+AG G K E IFV S+ + DGRI+ GD ++ ++G +L
Sbjct: 385 ------QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
Query: 530 LSHSEAVAMLKASAASPAVAL------KALEVQIVEEATQNAEEQP---STFSEN-EYDA 579
++ +AV +L+ + + + L + E+ E+ T++A+ P S EN E D
Sbjct: 439 FTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDE 498
Query: 580 SWSPSWVMWLGLP----------STLHSCHDIVLRRSYLGSWGFSIVG------------ 617
+ S LP + + D + + L + I+G
Sbjct: 499 DFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSK 558
Query: 618 -------GYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670
G T FI++++ P + G+L GD ++ VNG++ +G +H +V +
Sbjct: 559 FSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 671 LKEQRNKVTL 680
LKE +VT+
Sbjct: 619 LKELPIEVTM 628
Score = 97.4 bits (241), Expect = 4e-20
Identities = 173/717 (24%), Positives = 275/717 (38%), Gaps = 186/717 (25%)
Query: 117 SSVCKDVMQR-CD--LEAHLKNRCPGASHRRVALERRKTSRTQAEIEN--ENGPTLLD-- 169
SS KDV++ CD L+ H+ + + L+R+ + +I +G T+ D
Sbjct: 879 SSPPKDVIENSCDPVLDLHMSLE---ELYTQNLLQRQDENTPSVDISMGPASGFTINDYT 935
Query: 170 PAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPA-------FEESAGADTTQ- 221
PA + + +C T V E HL S +S+ L + A E+S+ A +
Sbjct: 936 PANAIEQQYECENT-IVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAEC 994
Query: 222 ---QPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLL 278
Q +S E TI I + N LG+++ + + ++++ + G I+RDGR+
Sbjct: 995 VMLQNVSKESFE-RTINIAKGNS--SLGMTVSANKDG--LGMIVRSIIHGGAISRDGRIA 1049
Query: 279 AGDQILQVNNYNISNVSHNYARAVLSQ-------------PCNTLH-------------- 311
GD IL +N + +V++ ARA+L + P L
Sbjct: 1050 IGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVM 1109
Query: 312 ------------LTVLRERRFGNRAHN------HSDSNSPREEIFQVALHKRDS------ 347
+ L ER G + +S+ N PR +V L + S
Sbjct: 1110 ALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR----RVELWREPSKSLGIS 1165
Query: 348 ---GEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAA 404
G +G +L G+FI +LE A ++G L DR++ ++G DL+ + E A
Sbjct: 1166 IVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAV 1225
Query: 405 QIIQASGE----RVNLTIARPGK-PQPG--NTIREAGNHSSS---------------SQH 442
+ I+ +G V I RP K P P + + N SS+ SQ
Sbjct: 1226 EAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQS 1285
Query: 443 HT-----------PPPYYSRPSSHKDLTQCVTCQ-------------------------- 465
+ PPP + D TQ +
Sbjct: 1286 ESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLT 1345
Query: 466 -EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNING 524
E H+ ++ H LG+++AG + + +F+ + P+G +DGR++ D LL ING
Sbjct: 1346 GELHMIELEKGHSGLGLSLAGNK--DRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 525 IDLTNLSHSEAVAMLKAS------------------AASPAVALKALEVQIVEEATQNAE 566
L SH A +++K + A P A++ L E QN E
Sbjct: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSN--SENLQNKE 1461
Query: 567 EQPS-TFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTN 625
+P+ T S+ D S S V L LP G G +I E T
Sbjct: 1462 TEPTVTTSDAAVDLS-SFKNVQHLELPKD-------------QGGLGIAI----SEEDTL 1503
Query: 626 QPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
IK++ A DGRLK GD I+AV+ VG + +LK + V LT+
Sbjct: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 93.6 bits (231), Expect = 6e-19
Identities = 88/331 (26%), Positives = 145/331 (43%), Gaps = 40/331 (12%)
Query: 361 EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYG-TPELAAQIIQASGERVNLTIA 419
E G+F+ ++ EG +A +DGRL D++LAING L T + A I+Q + + V L IA
Sbjct: 162 ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
Query: 420 RPGKPQPGNTI--REAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHE 477
R PQ + I R S+ S H P + H + + V
Sbjct: 222 RGSLPQLVSPIVSRSPSAASTISAHSNPVHW-----QHMETIELVN-----------DGS 265
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
LG + GG+ + + V ++ P G + GR+ GD +L I DL +S +
Sbjct: 266 GLGFGIIGGKATG-----VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
Query: 538 MLK--ASAASPAVALKALEVQIVEEATQ-NAEEQPSTFSENEYDASWSPSWVMWLGLPST 594
+L+ + +A A+E + A P++ E DAS
Sbjct: 321 VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKG---------E 371
Query: 595 LHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIV 652
D+ L ++ G G +I G Y + +P F+K+I + +DGR++ GD I+
Sbjct: 372 ESETFDVELTKNVQGL-GITIAG-YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
Query: 653 AVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
AV+G + G ++ V +L+ V LT++
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM 460
Score = 82.8 bits (203), Expect = 1e-15
Identities = 92/373 (24%), Positives = 158/373 (42%), Gaps = 37/373 (9%)
Query: 336 EIFQVALHKRDSGEQLGIKLVRRTDEP--GVFILDLLEGGLAAQDGRLSSNDRVLAINGH 393
E+ + L K SG LG+ L D VFI+ + G A +DGRL D +L ING
Sbjct: 1347 ELHMIELEKGHSG--LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQ 1404
Query: 394 DLKYGTPELAAQIIQASGERVNLTIARPGKPQ------PGNTIREAGNHSSSSQHHTPPP 447
L + + A+ II+ + +V + R PGN + ++S + Q+ P
Sbjct: 1405 ILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEP 1464
Query: 448 YYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCL 507
+ + DL+ Q H+ + K+ LG+ ++ + SG + + S+ HG
Sbjct: 1465 TVTTSDAAVDLSSFKNVQ--HLELPKD-QGGLGIAIS-EEDTLSG---VIIKSLTEHGVA 1517
Query: 508 ARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKA--LEVQIVEEATQNA 565
A DGR+K GD +L ++ + + +++LK + + + + A + Q V A A
Sbjct: 1518 ATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAA 1577
Query: 566 EEQPSTFS-------------ENEYDASWSPSWVMWLGLPST---LHSCHDIVLRRSYLG 609
+ S E+ + S S + ++ P+T + C +
Sbjct: 1578 SGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRT 1637
Query: 610 SWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVP 669
G SIVGG + I + A DGRL GD I+ VNG+ +H +
Sbjct: 1638 GLGLSIVGG--SDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAIN 1695
Query: 670 MLKEQRNKVTLTV 682
+L++ +V LT+
Sbjct: 1696 VLRQTPQRVRLTL 1708
Score = 74.7 bits (182), Expect = 3e-13
Identities = 66/224 (29%), Positives = 95/224 (42%), Gaps = 27/224 (12%)
Query: 465 QEKHITV---KKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLN 521
Q +H+ V K P LG +V G R GEL IFV + RDGR+K D +L
Sbjct: 131 QGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILA 190
Query: 522 INGIDL-TNLSHSEAVAML-KASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDA 579
ING L ++H +A+++L KA V + Q+V + ST S +
Sbjct: 191 INGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPV 250
Query: 580 SWSPSWVMWLGLPSTLHSCHDIVLRRSYLGS-WGFSIVGGYEENHTNQPFFIKTIVLGTP 638
W T+ +D GS GF I+GG +KTI+ G
Sbjct: 251 HWQHM--------ETIELVND--------GSGLGFGIIGGKATG-----VIVKTILPGGV 289
Query: 639 AYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
A GRL GD I+ + GMS + +L++ N+V L +
Sbjct: 290 ADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Score = 72.8 bits (177), Expect = 1e-12
Identities = 98/450 (21%), Positives = 171/450 (38%), Gaps = 122/450 (27%)
Query: 335 EEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAIN--- 391
+E F+ ++ LG+ + D G+ + ++ GG ++DGR++ D +L+IN
Sbjct: 1002 KESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
Query: 392 -------------------GHDLKY------GTPELAAQIIQASGERVNLTI--ARPGKP 424
G D+K E + Q SG + L I + G+
Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121
Query: 425 QPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVA 484
P RE G S +T +++P + + + +EP +SLG+++
Sbjct: 1122 IPELPEREEGEGEESELQNTAYSNWNQP--------------RRVELWREPSKSLGISIV 1167
Query: 485 GGRGSKS----GEL--PIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAM 538
GGRG S GE+ IF+ V ++G +K GD ++ ++G+DL + SH +AV
Sbjct: 1168 GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEA 1227
Query: 539 LKASAASPAVAL---------------------------------KALEVQIVEEATQNA 565
++ A +P V + +L++ + +Q+
Sbjct: 1228 IR-KAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSE 1286
Query: 566 EE------------QPSTFSE--------------------NEYDASWSPSWVMWLGLPS 593
E PS F+E +E+ SW + L
Sbjct: 1287 SEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTG 1346
Query: 594 TLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVA 653
LH I L + + G G S+ G ++ + FI I A DGRL+ D ++
Sbjct: 1347 ELHM---IELEKGHSG-LGLSLAG--NKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLE 1400
Query: 654 VNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
+NG G SH ++K +KV + I
Sbjct: 1401 INGQILYGRSHQNASSIIKCAPSKVKIIFI 1430
Score = 43.5 bits (101), Expect = 7e-04
Identities = 35/123 (28%), Positives = 61/123 (49%), Gaps = 8/123 (6%)
Query: 198 STWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNET-- 255
S+ +E+P L + + Q PL++ E I IE+ + + LG SI+ +
Sbjct: 667 SSETEDPVL--AMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSK--GLGFSILDYQDPID 722
Query: 256 -PLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYA-RAVLSQPCNTLHLT 313
I+I+ + G+ +DGRLL GD+++ VN+ N+ N S A A+ P T+ +
Sbjct: 723 PASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIG 782
Query: 314 VLR 316
V +
Sbjct: 783 VAK 785
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/232 (24%), Positives = 81/232 (34%), Gaps = 38/232 (16%)
Query: 340 VALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGT 399
V H E G+ + FI +L G G+L S D +L +NG L
Sbjct: 552 VVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
Query: 400 PELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLT 459
+ I++ V + R + P T E + T P H DL
Sbjct: 612 HQDVVNILKELPIEVTMVCCR--RTVPPTTQSELDSLDLCDIELTEKP-------HVDLG 662
Query: 460 QCVTCQEKHITV---------KKEPHESLGMTVAG------GRGSKS------------- 491
+ + E V +E L M AG +GSK
Sbjct: 663 EFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPID 722
Query: 492 -GELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
I + S+ P G +DGR+ GD L+ +N ++L N S EAV LK +
Sbjct: 723 PASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
Score = 41.6 bits (96), Expect = 0.002
Identities = 60/269 (22%), Positives = 106/269 (39%), Gaps = 60/269 (22%)
Query: 230 EITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNY 289
EI + + + LGIS+ E + + I+ V +G + G+L +GD++L+VN
Sbjct: 550 EIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
Query: 290 NISNVSHNYARAVLSQ--------------PCNT-----------LHLTVLRERRFGNRA 324
+ +H +L + P T + LT G
Sbjct: 606 TLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFI 665
Query: 325 HNH---------SDSNSPREEIFQVALHKRDSGEQ----------LGIKLVRRTD--EPG 363
+ +D+ EE+ Q L ++G Q LG ++ D +P
Sbjct: 666 GSSETEDPVLAMTDAGQSTEEV-QAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPA 724
Query: 364 ---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQ-ASGERVNLTIA 419
+ I L+ GG+A +DGRL DR++ +N +L+ + E A + ++ A V + +A
Sbjct: 725 STVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVA 784
Query: 420 RPGKPQPGNTIREAGNHSSSSQHHTPPPY 448
+P P E G S+ PP+
Sbjct: 785 KPLPLSP-----EEGYVSAKEDSFLYPPH 808
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 189 bits (479), Expect = 1e-47
Identities = 137/423 (32%), Positives = 211/423 (49%), Gaps = 46/423 (10%)
Query: 153 SRTQAEIENENG--PTLLDPAGTLS------PEADCLGTGAVPVERHLTSASLSTWSEEP 204
S + + IE+++G P + G++ PE++ +++ +S S+E
Sbjct: 1337 SSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEI 1396
Query: 205 GLDNPAFEESAGADTT-----QQPLSLPE-------GEITTIEIHRSNPYIQLGISIVGG 252
L + S AD T Q PLS+ G+ IEI + LG+SIVGG
Sbjct: 1397 PLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS--GLGLSIVGG 1454
Query: 253 NETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHL 312
+TPL IVI EVY +G ARDGRL AGDQIL+VN ++ N SH A L Q + L
Sbjct: 1455 KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRL 1514
Query: 313 TVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEG 372
V R+ AH + N EIF V L K+ +G LG+ +V + + GVFI D+++G
Sbjct: 1515 VVYRD-----EAHYRDEENL---EIFPVDLQKK-AGRGLGLSIVGKRNGSGVFISDIVKG 1565
Query: 373 GLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA--RPGKPQPGNTI 430
G A DGRL D++L++NG D++ + E A I++ + V L I R G T
Sbjct: 1566 GAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTT 1625
Query: 431 REAGNHSSSSQHHTPPPYYS-------------RPSSHKDLTQCVTCQEKHITVKKEPHE 477
+ S S H + P ++ R S + + + + +E +
Sbjct: 1626 SQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSD 1685
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
+LG+++AGGRGS G++P+F+ + G AR ++K GD +++ING L LSH++ V
Sbjct: 1686 ALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 538 MLK 540
+LK
Sbjct: 1746 LLK 1748
Score = 98.2 bits (243), Expect = 2e-20
Identities = 95/370 (25%), Positives = 159/370 (42%), Gaps = 61/370 (16%)
Query: 333 PREEIFQVALHKRDSGEQLGIKLVRRTDEP--GVFILDLLEGGLAAQDGRLSSNDRVLAI 390
P +E+ + + K SG LG+ +V D P + I ++ E G AA+DGRL + D++L +
Sbjct: 1432 PGQEMI-IEISKGRSG--LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEV 1488
Query: 391 NGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYS 450
NG DL+ + E A ++ + ++V L + R EA + P
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVVYRD----------EAHYRDEENLEIFP----- 1533
Query: 451 RPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARD 510
+ ++K+ LG+++ G R +F++ + G D
Sbjct: 1534 ------------------VDLQKKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLD 1571
Query: 511 GRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPS 570
GR+ +GD +L++NG D+ N S +LK A V L+ ++ + Q S
Sbjct: 1572 GRLIQGDQILSVNGEDMRNASQETVATILKC--AQGLVQLEIGRLRAGSWTSARTTSQNS 1629
Query: 571 TFSENEYDASWSPSWVMWL-GL-----------PSTLHSCHD-----IVLRRSYLGSWGF 613
S+ +S PS+ + GL PS +S D + + R + G
Sbjct: 1630 QGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGI 1689
Query: 614 SIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKE 673
SI GG + P FI I A +LK GD IV++NG G+SH+ +V +LK
Sbjct: 1690 SIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Query: 674 QRNKVTLTVI 683
++ L V+
Sbjct: 1750 AYGRIILQVV 1759
Score = 94.4 bits (233), Expect = 3e-19
Identities = 83/307 (27%), Positives = 146/307 (47%), Gaps = 23/307 (7%)
Query: 245 LGISIVGGNETPL--INIVIQEVYRDGVIARDGRLLAGDQILQVNNYNIS-NVSHNYARA 301
LG S+V L ++I +++V V RD RL DQIL +N+ + N+SH A A
Sbjct: 145 LGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIA 204
Query: 302 VLSQPCNTLHLTVLRE--RRFGNRAHNHSDSNSPRE----EIFQVALHKRDSGEQLGIKL 355
+L Q +L L V RE + + + +D+ P + +V L SG GI
Sbjct: 205 LLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVG 264
Query: 356 VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVN 415
+ + GV + ++ GGLA +DGRL + D +L I G +++ T E AQ+++ G V
Sbjct: 265 GKTS---GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVR 321
Query: 416 LTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEP 475
+ +AR P I ++ P P S L + ++ + ++
Sbjct: 322 MLVAR----DPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY-----NVELVRKD 372
Query: 476 HESLGMTVAGGRG-SKSGELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+SLG+ + G G S +GE I+V S+ P +G I+ D ++ ++G+++ ++
Sbjct: 373 GQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432
Query: 534 EAVAMLK 540
+ V +L+
Sbjct: 433 DVVEVLR 439
Score = 88.6 bits (218), Expect = 2e-17
Identities = 110/480 (22%), Positives = 182/480 (37%), Gaps = 94/480 (19%)
Query: 212 EESAGADTT--QQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDG 269
EE A D Q+ LP GE+ IE+ + LG+S+ G + ++I + + +G
Sbjct: 1217 EEDAFTDQKIRQRYADLP-GELHIIELEKDKN--GLGLSLAGNKDRSRMSIFVVGINPEG 1273
Query: 270 VIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNR------ 323
A DGR+ GD++L++NN + SH A A++ + + L +R N+
Sbjct: 1274 PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPF 1333
Query: 324 -AHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLS 382
+ S S+ + + + D ++GIK + ++ + + + +
Sbjct: 1334 PVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQ----------- 1382
Query: 383 SNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQH 442
KY T + S + + L A ++ S+
Sbjct: 1383 ------------QKYPTK------VSFSSQEIPLA--------------PASSYHSTDAD 1410
Query: 443 HTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVP 502
T + P S T + ++ I + LG+++ GG+ + I + V
Sbjct: 1411 FTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLN--AIVIHEVY 1468
Query: 503 PHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEAT 562
G ARDGR+ GD +L +NG+DL N SH EA+ L+ + K V +EA
Sbjct: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQ------KVRLVVYRDEAH 1522
Query: 563 QNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEEN 622
EE F + L++ G SIVG
Sbjct: 1523 YRDEENLEIF---------------------------PVDLQKKAGRGLGLSIVG----K 1551
Query: 623 HTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
FI IV G A DGRL GD I++VNG S + +LK + V L +
Sbjct: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEI 1611
Score = 84.7 bits (208), Expect = 3e-16
Identities = 85/328 (25%), Positives = 151/328 (46%), Gaps = 47/328 (14%)
Query: 364 VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYG-TPELAAQIIQASGERVNLTIARPG 422
+F+ D+ G +A +D RL ND++LAIN L + + A ++Q + + L +AR
Sbjct: 162 IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR-- 219
Query: 423 KPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHES--LG 480
+P +T SS+S SS D T T H+ + ++ LG
Sbjct: 220 --EPVHT------KSSTS------------SSLNDTTLPETVCWGHVEEVELINDGSGLG 259
Query: 481 MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
+ GG+ S + V ++ P G RDGR++ GD +L I G ++ ++ + +L+
Sbjct: 260 FGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Query: 541 ASAASPAVALK---ALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHS 597
S + + A ++ + A T AS P G S+L
Sbjct: 315 NCGNSVRMLVARDPAGDISVTPPAPAALPVALPTV------ASKGP------GSDSSLFE 362
Query: 598 CHDIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVN 655
+++ L R S G IVG +HT + ++K+I+ G+ AY++G ++ D IVAV+
Sbjct: 363 TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
Query: 656 GLSTVGMSHSALVPMLKEQRNKVTLTVI 683
G++ G ++ +V +L+ V LT++
Sbjct: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLV 450
Score = 74.3 bits (181), Expect = 3e-13
Identities = 72/272 (26%), Positives = 111/272 (40%), Gaps = 28/272 (10%)
Query: 413 RVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVK 472
R L + G GN R + N + S P + + Q ++I ++
Sbjct: 79 RKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIE 138
Query: 473 KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDL-TNLS 531
+ LG +V R G++ IFV V P RD R+K D +L IN L N+S
Sbjct: 139 RPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNIS 198
Query: 532 HSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGL 591
H +A+A+L+ + S L + + E S+ ++ P V W G
Sbjct: 199 HQQAIALLQQTTGS-------LRLIVAREPVHTKSSTSSSLNDTTL-----PETVCW-GH 245
Query: 592 PSTLHSCHDIVLRRSYLGS-WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650
+ +D GS GF IVGG ++TIV G A DGRL+ GD
Sbjct: 246 VEEVELIND--------GSGLGFGIVGG-----KTSGVVVRTIVPGGLADRDGRLQTGDH 292
Query: 651 IVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
I+ + G + GM+ + +L+ N V + V
Sbjct: 293 ILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLV 324
Score = 73.6 bits (179), Expect = 6e-13
Identities = 76/266 (28%), Positives = 111/266 (41%), Gaps = 43/266 (16%)
Query: 316 RERRFGNRAHNHSDSNSPR-EEIFQ---VALHKRDSGEQLGIKLVRRTDE-PGVFILDLL 370
RE G N S PR EIF+ V+L G Q IK ++ +E G+FI +L
Sbjct: 1049 REEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
Query: 371 EGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR--------PG 422
E A + L + D++L ++G DL+ + A + I+ +G V + P
Sbjct: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPN 1168
Query: 423 KPQPGNTIREAGNHSSSSQHH------TPPPYYSRPSSHKDLTQ---------CVTCQ-- 465
N I GN + +Q T PP P +K LT T Q
Sbjct: 1169 VHNKANKI--TGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKI 1226
Query: 466 ---------EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRG 516
E HI ++ LG+++AG + + IFV + P G A DGR++ G
Sbjct: 1227 RQRYADLPGELHIIELEKDKNGLGLSLAGNKDRS--RMSIFVVGINPEGPAAADGRMRIG 1284
Query: 517 DVLLNINGIDLTNLSHSEAVAMLKAS 542
D LL IN L SH A A++K +
Sbjct: 1285 DELLEINNQILYGRSHQNASAIIKTA 1310
Score = 73.2 bits (178), Expect = 8e-13
Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 28/229 (12%)
Query: 214 SAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIAR 273
S+ + T P ++ G + +E+ N LG IVGG + +V++ + G+ R
Sbjct: 229 SSSLNDTTLPETVCWGHVEEVEL--INDGSGLGFGIVGGKTS---GVVVRTIVPGGLADR 283
Query: 274 DGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERR-------------- 319
DGRL GD IL++ N+ ++ VL N++ + V R+
Sbjct: 284 DGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALP 343
Query: 320 --FGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLV------RRTDEPGVFILDLLE 371
A S+S E + V L ++D G+ LGI++V + G+++ ++
Sbjct: 344 VALPTVASKGPGSDSSLFETYNVELVRKD-GQSLGIRIVGYVGTSHTGEASGIYVKSIIP 402
Query: 372 GGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
G A +G + ND+++A++G +++ ++++ +G+ V+LT+ R
Sbjct: 403 GSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
Score = 66.2 bits (160), Expect = 9e-11
Identities = 64/258 (24%), Positives = 107/258 (41%), Gaps = 50/258 (19%)
Query: 469 ITVKKEPHESLGMTVAGG----RGSKSGE--LPIFVTSVPPHGCLARDGRIKRGDVLLNI 522
+ + +EP+ SLG+++ GG + K+GE IF+ V + +K GD +L +
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128
Query: 523 NGIDLTNLSHSEAVAMLKASAASPAVAL------------------------KALEVQIV 558
+G+DL N SHSEAV +K +A +P V + + + Q
Sbjct: 1129 SGVDLQNASHSEAVEAIK-NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEK 1187
Query: 559 EEATQNAEEQPSTF-----------SENEYDASWSPSWVM--WLGLPSTLHSCHDIVLRR 605
+E Q P ENE + +++ + + LP LH I+
Sbjct: 1188 KEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELH----IIELE 1243
Query: 606 SYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHS 665
G S+ G ++ + F+ I PA DGR++ GD ++ +N G SH
Sbjct: 1244 KDKNGLGLSLAGN--KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQ 1301
Query: 666 ALVPMLKEQRNKVTLTVI 683
++K +KV L I
Sbjct: 1302 NASAIIKTAPSKVKLVFI 1319
Score = 55.1 bits (131), Expect = 2e-07
Identities = 83/349 (23%), Positives = 129/349 (36%), Gaps = 88/349 (25%)
Query: 151 KTSRTQAEIENE-NGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGL--- 206
KTS I N+ GP+LL ++ + +P+ +H + +S S G+
Sbjct: 981 KTSLDLGMIPNDVQGPSLLIDLPVVAQRRE---QEDLPLYQHQATRVISKASAYTGMLSS 1037
Query: 207 -------DNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGG------- 252
+ P EE G +T P G +EI R P + LGISIVGG
Sbjct: 1038 RYATDTCELPEREEGEGEET---PNFSHWGPPRIVEIFRE-PNVSLGISIVGGQTVIKRL 1093
Query: 253 -NETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLH 311
N L I I++V D + L GD+IL+V+ ++ N SH+ A + N +
Sbjct: 1094 KNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV 1153
Query: 312 LTV------------------------------LRERRFG------------NRAHNHSD 329
V +E+R G + SD
Sbjct: 1154 FIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSD 1213
Query: 330 SNSPRE----------------EIFQVALHKRDSGEQLGIKLVRRTDEP--GVFILDLLE 371
N + E+ + L K +G LG+ L D +F++ +
Sbjct: 1214 ENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNG--LGLSLAGNKDRSRMSIFVVGINP 1271
Query: 372 GGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
G AA DGR+ D +L IN L + + A+ II+ + +V L R
Sbjct: 1272 EGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIR 1320
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/93 (33%), Positives = 46/93 (49%), Gaps = 6/93 (6%)
Query: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL-SQPCNTLHLTVLRER 318
IVI+ + DGV R G LL GD+++ VN Y + N S A +L + P +HL + +
Sbjct: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPL 773
Query: 319 RFGNRAHN----HSDSNSPREEIFQVALHKRDS 347
N + HS SN + E F +H +S
Sbjct: 774 VEDNEEESCYILHSSSNEDKTE-FSGTIHDINS 805
Score = 36.2 bits (82), Expect = 0.10
Identities = 51/208 (24%), Positives = 81/208 (38%), Gaps = 35/208 (16%)
Query: 497 FVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQ 556
+++S+ G + G ++ D LL +NG+ L S EAV+ LK P L
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLK--EVPPPFTLVCCRRL 639
Query: 557 IVEEATQNAEEQPST-FSENEYD---------------ASWSPSWVMWLGLPSTLHSCHD 600
+EA+ + + T E E D A WSP + + + C
Sbjct: 640 FDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE----VKIVELVKDCKG 695
Query: 601 IVLRRSYLGSWGFSIVGGYEE--NHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLS 658
+ GFSI+ Y++ + T I+++V A G L GD +V+VN
Sbjct: 696 L----------GFSIL-DYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744
Query: 659 TVGMSHSALVPMLKEQRNKVTLTVICWP 686
S + V +LK + IC P
Sbjct: 745 LDNTSLAEAVEILKAVPPGLVHLGICKP 772
Score = 32.3 bits (72), Expect = 1.5
Identities = 40/168 (23%), Positives = 63/168 (37%), Gaps = 33/168 (19%)
Query: 169 DPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPE 228
DPAG +S P L A + S+ PG D+ FE T L +
Sbjct: 327 DPAGDISVTP--------PAPAALPVALPTVASKGPGSDSSLFE------TYNVELVRKD 372
Query: 229 GEITTIEIHRSNPYIQLGISIVGGNET-PLINIVIQEVYRDGVIARDGRLLAGDQILQVN 287
G+ I I + VG + T I ++ + +G + D+I+ V+
Sbjct: 373 GQSLGIRI----------VGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
Query: 288 NYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPRE 335
NI +++ VL +HLT++R + S S SP E
Sbjct: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRRKT--------SSSTSPLE 462
Score = 31.6 bits (70), Expect = 2.6
Identities = 18/46 (39%), Positives = 26/46 (56%)
Query: 496 IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKA 541
I + S+ G R G + GD L+++N L N S +EAV +LKA
Sbjct: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKA 759
Score = 30.8 bits (68), Expect = 4.4
Identities = 21/63 (33%), Positives = 29/63 (46%)
Query: 618 GYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNK 677
G E + + +I +IV G P G L+ D ++ VNG+ G S V LKE
Sbjct: 571 GVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP 630
Query: 678 VTL 680
TL
Sbjct: 631 FTL 633
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 113 bits (283), Expect = 5e-25
Identities = 103/373 (27%), Positives = 155/373 (41%), Gaps = 73/373 (19%)
Query: 228 EGEITTIEIHRSNPYIQLGISIVGGNETPLIN----IVIQEVYRDGVIARDGRLLAGDQI 283
E E I + R N LG SI GG + P I I I ++ G A DGRL D I
Sbjct: 42 EYEFEEITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
Query: 284 LQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALH 343
L+VN ++S VSH+ A L + + + L V R R E + ++ L
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-------------LETVVEIKLF 146
Query: 344 KRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKY 397
K G LG + V PG +++ +++GG A +DGRL DR+L +N + L+
Sbjct: 147 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 204
Query: 398 GTPELAAQIIQASGERVNLTIARP---------GKPQ-------PGNTIREAGNHSSSSQ 441
T E A I++ + E V L + +P G P P +GN+ +
Sbjct: 205 VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEY 264
Query: 442 HHTPPPY----YSRPSSHKDLTQCVTCQEKHITVKKEP---------------------- 475
+ PP YS H + T +H T ++P
Sbjct: 265 KTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKG 324
Query: 476 HESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEA 535
LG + GG + IFV+ + G G ++RGD +L++NGIDL SH +A
Sbjct: 325 STGLGFNIVGGEDGEG----IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 380
Query: 536 VAMLKASAASPAV 548
A LK + + +
Sbjct: 381 AAALKGAGQTVTI 393
Score = 96.7 bits (239), Expect = 7e-20
Identities = 107/398 (26%), Positives = 163/398 (40%), Gaps = 101/398 (25%)
Query: 336 EIFQVALHKRDSGEQLGIKLVRRTD------EPGVFILDLLEGGLAAQDGRLSSNDRVLA 389
E ++ L + +SG LG + TD +PG+FI ++ GG AA+DGRL ND +L
Sbjct: 44 EFEEITLERGNSG--LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101
Query: 390 INGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYY 449
+N D+ + A + ++ +G V L + R
Sbjct: 102 VNEVDVSEVSHSKAVEALKEAGSIVRLYVRR----------------------------- 132
Query: 450 SRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS--GELPIFVTSVPPHGCL 507
+ + + V I + K P + LG ++AGG G++ G+ I+VT + G
Sbjct: 133 -----RRPILETVV----EIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAA 182
Query: 508 ARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIV----EEATQ 563
+DGR++ GD LL +N L ++H EAVA+LK + S V LK + +
Sbjct: 183 QKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT--SEVVYLKVGKPTTIYMTDPYGPP 240
Query: 564 NAEEQPSTFSEN----------EYDASWSP-SWVMWLGLPS--------TLHSCHD---- 600
+ S EN EY S P S + +P T HS H
Sbjct: 241 DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300
Query: 601 ------------------IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYD 642
+VL + G GF+IVGG + + F+ I+ G PA
Sbjct: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGL-GFNIVGGED----GEGIFVSFILAGGPADLS 355
Query: 643 GRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
G L+ GD I++VNG+ G SH LK VT+
Sbjct: 356 GELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Score = 69.7 bits (169), Expect = 9e-12
Identities = 58/211 (27%), Positives = 93/211 (44%), Gaps = 43/211 (20%)
Query: 476 HESLGMTVAGGRGSKS-GELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + G+ P IF+T + P G A DGR++ D +L +N +D++ +SHS
Sbjct: 54 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 113
Query: 534 EAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPS 593
+AV LK + + + ++ +P
Sbjct: 114 KAVEALKEAGSIVRLYVR--------------RRRP------------------------ 135
Query: 594 TLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMI 651
L + +I L + G GFSI GG H + ++ I+ G A DGRL+ GD +
Sbjct: 136 ILETVVEIKLFKGPKGL-GFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194
Query: 652 VAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
+ VN S ++H V +LK V L V
Sbjct: 195 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 3/85 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H FI I+ G A DGRL+ D I+ VN +
Sbjct: 47 EITLERGNSGL-GFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105
Query: 658 STVGMSHSALVPMLKEQRNKVTLTV 682
+SHS V LKE + V L V
Sbjct: 106 DVSEVSHSKAVEALKEAGSIVRLYV 130
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 111 bits (277), Expect = 3e-24
Identities = 96/354 (27%), Positives = 156/354 (44%), Gaps = 50/354 (14%)
Query: 218 DTTQQP--LSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLI----NIVIQEVYRDGVI 271
DT + P ++ EGE+ EI LG SI GG + P I +I I ++ G
Sbjct: 43 DTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAA 102
Query: 272 ARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSN 331
A+DGRL D IL VN ++ V+H+ A L + + + L V+R +
Sbjct: 103 AQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK------------- 149
Query: 332 SPREEIFQVALHKRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLAAQDGRLSSND 385
P E++ ++ L K G LG + V PG +++ ++EGG A +DGRL D
Sbjct: 150 PPAEKVMEIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 207
Query: 386 RVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQH--- 442
++LA+N L+ E A ++ + + V L +A+P ++ +S SQH
Sbjct: 208 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDN 267
Query: 443 --------HTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHE--------SLGMTVAGG 486
T P P+S + + + +EP LG + GG
Sbjct: 268 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG 327
Query: 487 RGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
+ IF++ + G G +++GD +L++NG+DL N SH +A LK
Sbjct: 328 EDGEG----IFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 377
Score = 108 bits (269), Expect = 2e-23
Identities = 101/373 (27%), Positives = 157/373 (42%), Gaps = 74/373 (19%)
Query: 336 EIFQVALHKRDSGEQLGIKLVRRTD------EPGVFILDLLEGGLAAQDGRLSSNDRVLA 389
E ++ L + +SG LG + TD +P +FI ++ GG AAQDGRL ND +L
Sbjct: 59 EYEEITLERGNSG--LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
Query: 390 INGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYY 449
+N D++ T A + ++ +G V L + R + P + E
Sbjct: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR--RKPPAEKVME----------------- 157
Query: 450 SRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS--GELPIFVTSVPPHGCL 507
I + K P + LG ++AGG G++ G+ I+VT + G
Sbjct: 158 -------------------IKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 197
Query: 508 ARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK-------ASAASPAVALKALEVQIVEE 560
+DGR++ GD +L +N + L ++ H +AVA LK A P+ A + +
Sbjct: 198 HKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 257
Query: 561 ATQNAEEQPSTFSENEY-------------DASWSPSWVMWLGLPSTLHSCHDIVLRRSY 607
T ++ + S + Y +SP LG IV+ R
Sbjct: 258 TTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGS 317
Query: 608 LGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSAL 667
G GF+IVGG + + FI I+ G PA G L+ GD I++VNG+ SH
Sbjct: 318 TG-LGFNIVGGED----GEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
Query: 668 VPMLKEQRNKVTL 680
LK VT+
Sbjct: 373 AIALKNAGQTVTI 385
Score = 67.4 bits (163), Expect = 4e-11
Identities = 58/219 (26%), Positives = 93/219 (42%), Gaps = 59/219 (26%)
Query: 476 HESLGMTVAGGRGSKS-GELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + G+ P IF+T + P G A+DGR++ D +L +N +D+ ++HS
Sbjct: 69 NSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 128
Query: 534 EAVAMLKASAASPAV--------ALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
AV LK + + + A K +E+++++
Sbjct: 129 AAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKG------------------------- 163
Query: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDG 643
P L GFSI GG H + ++ I+ G A+ DG
Sbjct: 164 ------PKGL----------------GFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 201
Query: 644 RLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
RL+ GD I+AVN + + H V LK + V L V
Sbjct: 202 RLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
Score = 67.0 bits (162), Expect = 6e-11
Identities = 60/230 (26%), Positives = 94/230 (40%), Gaps = 53/230 (23%)
Query: 245 LGISIVGGNETPLI----NIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR 300
LG SI GG I +I + ++ G +DGRL GD+IL VN+ + +V H A
Sbjct: 167 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 226
Query: 301 AVLSQPCNTLHLTVLRE------------------------------------------- 317
A L + ++L V +
Sbjct: 227 AALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPT 286
Query: 318 --RRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLA 375
RR+ A + E ++ +H+ +G LG +V D G+FI +L GG A
Sbjct: 287 SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTG--LGFNIVGGEDGEGIFISFILAGGPA 344
Query: 376 AQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
G L D++L++NG DL+ + E AA ++ +G+ V TI KP+
Sbjct: 345 DLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTV--TIIAQYKPE 392
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H FI I+ G A DGRL+ D I+ VN +
Sbjct: 62 EITLERGNSGL-GFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120
Query: 658 STVGMSHSALVPMLKEQRNKVTLTVI 683
++HSA V LKE + V L V+
Sbjct: 121 DVREVTHSAAVEALKEAGSIVRLYVM 146
Score = 40.4 bits (93), Expect = 0.006
Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 6/109 (5%)
Query: 234 IEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISN 293
I IHR + LG +IVGG + I I + G G L GDQIL VN ++ N
Sbjct: 311 IVIHRGST--GLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 366
Query: 294 VSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVAL 342
SH A L T +T++ + + + + + RE++ +L
Sbjct: 367 ASHEQAAIALKNAGQT--VTIIAQYKPEEYSRFEAKIHDLREQLMNSSL 413
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 110 bits (275), Expect = 4e-24
Identities = 93/342 (27%), Positives = 150/342 (43%), Gaps = 48/342 (14%)
Query: 228 EGEITTIEIHRSNPYIQLGISIVGGNETPLI----NIVIQEVYRDGVIARDGRLLAGDQI 283
EGE+ EI LG SI GG + P I +I I ++ G A+DGRL D I
Sbjct: 101 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 284 LQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALH 343
L VN ++ V+H+ A L + + + L V+R + P E++ ++ L
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-------------PPAEKVMEIKLI 207
Query: 344 KRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKY 397
K G LG + V PG +++ ++EGG A +DGRL D++LA+N L+
Sbjct: 208 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLED 265
Query: 398 GTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQH-----------HTPP 446
E A ++ + + V L +A+P ++ +S SQH T
Sbjct: 266 VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDY 325
Query: 447 PYYSRPSSHKDLTQCVTCQEKHITVKKEPHE--------SLGMTVAGGRGSKSGELPIFV 498
P P+S + + + +EP LG + GG + IF+
Sbjct: 326 PTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEG----IFI 381
Query: 499 TSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
+ + G G +++GD +L++NG+DL N SH +A LK
Sbjct: 382 SFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 423
Score = 108 bits (269), Expect = 2e-23
Identities = 101/373 (27%), Positives = 157/373 (42%), Gaps = 74/373 (19%)
Query: 336 EIFQVALHKRDSGEQLGIKLVRRTD------EPGVFILDLLEGGLAAQDGRLSSNDRVLA 389
E ++ L + +SG LG + TD +P +FI ++ GG AAQDGRL ND +L
Sbjct: 105 EYEEITLERGNSG--LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
Query: 390 INGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYY 449
+N D++ T A + ++ +G V L + R + P + E
Sbjct: 163 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR--RKPPAEKVME----------------- 203
Query: 450 SRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS--GELPIFVTSVPPHGCL 507
I + K P + LG ++AGG G++ G+ I+VT + G
Sbjct: 204 -------------------IKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 243
Query: 508 ARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK-------ASAASPAVALKALEVQIVEE 560
+DGR++ GD +L +N + L ++ H +AVA LK A P+ A + +
Sbjct: 244 HKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 303
Query: 561 ATQNAEEQPSTFSENEY-------------DASWSPSWVMWLGLPSTLHSCHDIVLRRSY 607
T ++ + S + Y +SP LG IV+ R
Sbjct: 304 TTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGS 363
Query: 608 LGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSAL 667
G GF+IVGG + + FI I+ G PA G L+ GD I++VNG+ SH
Sbjct: 364 TG-LGFNIVGGED----GEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 418
Query: 668 VPMLKEQRNKVTL 680
LK VT+
Sbjct: 419 AIALKNAGQTVTI 431
Score = 67.4 bits (163), Expect = 4e-11
Identities = 58/219 (26%), Positives = 93/219 (42%), Gaps = 59/219 (26%)
Query: 476 HESLGMTVAGGRGSKS-GELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + G+ P IF+T + P G A+DGR++ D +L +N +D+ ++HS
Sbjct: 115 NSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHS 174
Query: 534 EAVAMLKASAASPAV--------ALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
AV LK + + + A K +E+++++
Sbjct: 175 AAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKG------------------------- 209
Query: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDG 643
P L GFSI GG H + ++ I+ G A+ DG
Sbjct: 210 ------PKGL----------------GFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 247
Query: 644 RLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
RL+ GD I+AVN + + H V LK + V L V
Sbjct: 248 RLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
Score = 67.0 bits (162), Expect = 6e-11
Identities = 60/230 (26%), Positives = 94/230 (40%), Gaps = 53/230 (23%)
Query: 245 LGISIVGGNETPLI----NIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR 300
LG SI GG I +I + ++ G +DGRL GD+IL VN+ + +V H A
Sbjct: 213 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 272
Query: 301 AVLSQPCNTLHLTVLRE------------------------------------------- 317
A L + ++L V +
Sbjct: 273 AALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPT 332
Query: 318 --RRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLA 375
RR+ A + E ++ +H+ +G LG +V D G+FI +L GG A
Sbjct: 333 SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTG--LGFNIVGGEDGEGIFISFILAGGPA 390
Query: 376 AQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
G L D++L++NG DL+ + E AA ++ +G+ V TI KP+
Sbjct: 391 DLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTV--TIIAQYKPE 438
Score = 48.5 bits (114), Expect = 2e-05
Identities = 34/86 (39%), Positives = 44/86 (51%), Gaps = 3/86 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H FI I+ G A DGRL+ D I+ VN +
Sbjct: 108 EITLERGNSGL-GFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166
Query: 658 STVGMSHSALVPMLKEQRNKVTLTVI 683
++HSA V LKE + V L V+
Sbjct: 167 DVREVTHSAAVEALKEAGSIVRLYVM 192
Score = 40.4 bits (93), Expect = 0.006
Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 6/109 (5%)
Query: 234 IEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISN 293
I IHR + LG +IVGG + I I + G G L GDQIL VN ++ N
Sbjct: 357 IVIHRGST--GLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 412
Query: 294 VSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVAL 342
SH A L T +T++ + + + + + RE++ +L
Sbjct: 413 ASHEQAAIALKNAGQT--VTIIAQYKPEEYSRFEAKIHDLREQLMNSSL 459
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 110 bits (274), Expect = 6e-24
Identities = 97/341 (28%), Positives = 148/341 (43%), Gaps = 57/341 (16%)
Query: 245 LGISIVGGNETPLI----NIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR 300
LG SI GG + P + I I ++ G A DGRL D +L+VN ++S V H+ A
Sbjct: 141 LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV 200
Query: 301 AVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKL---VR 357
L + + L V R + P E I +V L K G LG + +
Sbjct: 201 EALKEAGPVVRLVVRRRQ-------------PPPETIMEVNLLKGPKG--LGFSIAGGIG 245
Query: 358 RTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERV 414
PG ++I ++EGG A +DGRL DR+LA+N +L+ E A ++ + + V
Sbjct: 246 NQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMV 305
Query: 415 NLTIARPGK---------PQPGNTIRE-AGNHSSSSQH-----------------HTPPP 447
L +A+PG P +T A NH S + PP
Sbjct: 306 YLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPT 365
Query: 448 YYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCL 507
YS H + T + + I + K LG + GG + IFV+ + G
Sbjct: 366 RYSPIPRHMLAEEDFTREPRKIILHK-GSTGLGFNIVGGEDGEG----IFVSFILAGGPA 420
Query: 508 ARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAV 548
G ++RGD +L++NG++L N +H +A A LK + S +
Sbjct: 421 DLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTI 461
Score = 100 bits (250), Expect = 3e-21
Identities = 108/390 (27%), Positives = 164/390 (42%), Gaps = 84/390 (21%)
Query: 326 NHSDSNSPREEIFQVALHKRDSGEQL----GIKLVRRTDEPGVFILDLLEGGLAAQDGRL 381
N SD EEI L + +SG GI D+PG+FI ++ GG AA DGRL
Sbjct: 121 NGSDGMFKYEEI---VLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRL 177
Query: 382 SSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQ 441
ND VL +N D+ A + ++ +G V L + R + P TI E
Sbjct: 178 GVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRR--RQPPPETIME--------- 226
Query: 442 HHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSK--SGELPIFVT 499
+ + K P + LG ++AGG G++ G+ I++T
Sbjct: 227 ---------------------------VNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYIT 258
Query: 500 SVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVE 559
+ G +DGR++ GD LL +N +L ++ H EAVA LK + S V LK + +
Sbjct: 259 KIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT--SDMVYLKVAKPGSLH 316
Query: 560 EATQNA-EEQPSTFSENEYDASWSPSWVMWLG-------------LPSTLHS-------- 597
A + STF+ + S + +LG +P T +S
Sbjct: 317 LNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLA 376
Query: 598 -------CHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650
I+L + G GF+IVGG + + F+ I+ G PA G L+ GD
Sbjct: 377 EEDFTREPRKIILHKGSTG-LGFNIVGGED----GEGIFVSFILAGGPADLSGELRRGDR 431
Query: 651 IVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
I++VNG++ +H LK VT+
Sbjct: 432 ILSVNGVNLRNATHEQAAAALKRAGQSVTI 461
Score = 72.8 bits (177), Expect = 1e-12
Identities = 67/223 (30%), Positives = 93/223 (41%), Gaps = 44/223 (19%)
Query: 471 VKKEPHESLGMTVAGGRGSKS--GELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
V + + LG ++AGG + + IF+T + P G A DGR+ D +L +N +D++
Sbjct: 133 VLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVS 192
Query: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588
+ HS AV LK A P V L + + P T E V
Sbjct: 193 EVVHSRAVEALKE--AGPVVRL----------VVRRRQPPPETIME-----------VNL 229
Query: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLK 646
L P L GFSI GG H + +I I+ G A DGRL+
Sbjct: 230 LKGPKGL----------------GFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQ 273
Query: 647 CGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWPGSL 689
GD ++AVN + + H V LK + V L V PGSL
Sbjct: 274 IGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKV-AKPGSL 315
Score = 46.6 bits (109), Expect = 8e-05
Identities = 40/122 (32%), Positives = 50/122 (40%), Gaps = 10/122 (8%)
Query: 570 STFSENEYDASWSPS-------WVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEEN 622
ST N SW P W + + +IVL R G GFSI GG +
Sbjct: 94 STPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLERGNSGL-GFSIAGGIDNP 152
Query: 623 HT--NQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
H + FI I+ G A DGRL D ++ VN + + HS V LKE V L
Sbjct: 153 HVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRL 212
Query: 681 TV 682
V
Sbjct: 213 VV 214
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 108 bits (269), Expect = 2e-23
Identities = 109/379 (28%), Positives = 163/379 (43%), Gaps = 75/379 (19%)
Query: 326 NHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------GVFILDLLEGGLAAQDG 379
N +D++ EEI L + +SG LG + TD P +FI ++ GG AAQDG
Sbjct: 214 NGTDADYEYEEI---TLERGNSG--LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG 268
Query: 380 RLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSS 439
RL ND +L +N D++ T A + ++ +G V L + R
Sbjct: 269 RLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR------------------- 309
Query: 440 SQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS--GELPIF 497
+P S K + I + K P + LG ++AGG G++ G+ I+
Sbjct: 310 ----------RKPVSEKIM---------EIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIY 349
Query: 498 VTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALE--- 554
VT + G +DG+++ GD LL +N + L ++H EAV LK + S V LK +
Sbjct: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT--SDFVYLKVAKPTS 407
Query: 555 ---------VQIVEEATQNAEE--QPSTF--SENEYDASWSPSWVMWLGLPSTLHSCHDI 601
I ++Q + PS+F A +SP LG +
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKV 467
Query: 602 VLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVG 661
VL R G GF+IVGG + + FI I+ G PA G L+ GD I++VN +
Sbjct: 468 VLHRGSTG-LGFNIVGGED----GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522
Query: 662 MSHSALVPMLKEQRNKVTL 680
SH LK VT+
Sbjct: 523 ASHEQAAAALKNAGQAVTI 541
Score = 106 bits (264), Expect = 8e-23
Identities = 92/361 (25%), Positives = 162/361 (44%), Gaps = 60/361 (16%)
Query: 206 LDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLI----NIV 261
L+ P + AD + ++L G LG SI GG + P I +I
Sbjct: 207 LETPTYVNGTDADYEYEEITLERGNSG------------LGFSIAGGTDNPHIGDDSSIF 254
Query: 262 IQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFG 321
I ++ G A+DGRL D IL+VN ++ +V+H+ A L + + + L V R +
Sbjct: 255 ITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314
Query: 322 NRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLA 375
E+I ++ L K G LG + V PG +++ ++EGG A
Sbjct: 315 -------------EKIMEIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 359
Query: 376 AQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGN 435
+DG+L D++LA+N L+ T E A ++ + + V L +A+P +
Sbjct: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
Query: 436 HSSSSQ---HHTPPPYY-----SRPSSHKDLTQCVTCQEKHITVKKEPHE--------SL 479
+SSSQ +H P + + P+ + +++ V ++ + +EP + L
Sbjct: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDE---ITREPRKVVLHRGSTGL 476
Query: 480 GMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML 539
G + GG + IF++ + G G +++GD ++++N +DL SH +A A L
Sbjct: 477 GFNIVGGEDGEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
Query: 540 K 540
K
Sbjct: 533 K 533
Score = 66.2 bits (160), Expect = 9e-11
Identities = 52/211 (24%), Positives = 90/211 (42%), Gaps = 43/211 (20%)
Query: 476 HESLGMTVAGGRGSK--SGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + + IF+T + G A+DGR++ D +L +N +D+ +++HS
Sbjct: 231 NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHS 290
Query: 534 EAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPS 593
+AV LK + + + +K +P + E P +
Sbjct: 291 KAVEALKEAGSIVRLYVK--------------RRKPVSEKIMEIKLIKGPKGL------- 329
Query: 594 TLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMI 651
GFSI GG H + ++ I+ G A+ DG+L+ GD +
Sbjct: 330 ------------------GFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
Query: 652 VAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
+AVN + ++H V LK + V L V
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/85 (38%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H + FI I+ G A DGRL+ D I+ VN +
Sbjct: 224 EITLERGNSGL-GFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282
Query: 658 STVGMSHSALVPMLKEQRNKVTLTV 682
++HS V LKE + V L V
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYV 307
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 108 bits (269), Expect = 2e-23
Identities = 109/379 (28%), Positives = 163/379 (43%), Gaps = 75/379 (19%)
Query: 326 NHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------GVFILDLLEGGLAAQDG 379
N +D++ EEI L + +SG LG + TD P +FI ++ GG AAQDG
Sbjct: 214 NGTDADYEYEEI---TLERGNSG--LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG 268
Query: 380 RLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSS 439
RL ND +L +N D++ T A + ++ +G V L + R
Sbjct: 269 RLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR------------------- 309
Query: 440 SQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS--GELPIF 497
+P S K + I + K P + LG ++AGG G++ G+ I+
Sbjct: 310 ----------RKPVSEKIM---------EIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIY 349
Query: 498 VTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALE--- 554
VT + G +DG+++ GD LL +N + L ++H EAV LK + S V LK +
Sbjct: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNT--SDFVYLKVAKPTS 407
Query: 555 ---------VQIVEEATQNAEE--QPSTF--SENEYDASWSPSWVMWLGLPSTLHSCHDI 601
I ++Q + PS+F A +SP LG +
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKV 467
Query: 602 VLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVG 661
VL R G GF+IVGG + + FI I+ G PA G L+ GD I++VN +
Sbjct: 468 VLHRGSTG-LGFNIVGGED----GEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522
Query: 662 MSHSALVPMLKEQRNKVTL 680
SH LK VT+
Sbjct: 523 ASHEQAAAALKNAGQAVTI 541
Score = 106 bits (264), Expect = 8e-23
Identities = 92/361 (25%), Positives = 162/361 (44%), Gaps = 60/361 (16%)
Query: 206 LDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLI----NIV 261
L+ P + AD + ++L G LG SI GG + P I +I
Sbjct: 207 LETPTYVNGTDADYEYEEITLERGNSG------------LGFSIAGGTDNPHIGDDSSIF 254
Query: 262 IQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFG 321
I ++ G A+DGRL D IL+VN ++ +V+H+ A L + + + L V R +
Sbjct: 255 ITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVS 314
Query: 322 NRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLA 375
E+I ++ L K G LG + V PG +++ ++EGG A
Sbjct: 315 -------------EKIMEIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAA 359
Query: 376 AQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGN 435
+DG+L D++LA+N L+ T E A ++ + + V L +A+P +
Sbjct: 360 HKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDI 419
Query: 436 HSSSSQ---HHTPPPYY-----SRPSSHKDLTQCVTCQEKHITVKKEPHE--------SL 479
+SSSQ +H P + + P+ + +++ V ++ + +EP + L
Sbjct: 420 TNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDE---ITREPRKVVLHRGSTGL 476
Query: 480 GMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML 539
G + GG + IF++ + G G +++GD ++++N +DL SH +A A L
Sbjct: 477 GFNIVGGEDGEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532
Query: 540 K 540
K
Sbjct: 533 K 533
Score = 66.2 bits (160), Expect = 9e-11
Identities = 52/211 (24%), Positives = 90/211 (42%), Gaps = 43/211 (20%)
Query: 476 HESLGMTVAGGRGSK--SGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + + IF+T + G A+DGR++ D +L +N +D+ +++HS
Sbjct: 231 NSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHS 290
Query: 534 EAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPS 593
+AV LK + + + +K +P + E P +
Sbjct: 291 KAVEALKEAGSIVRLYVK--------------RRKPVSEKIMEIKLIKGPKGL------- 329
Query: 594 TLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMI 651
GFSI GG H + ++ I+ G A+ DG+L+ GD +
Sbjct: 330 ------------------GFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKL 371
Query: 652 VAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
+AVN + ++H V LK + V L V
Sbjct: 372 LAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/85 (38%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H + FI I+ G A DGRL+ D I+ VN +
Sbjct: 224 EITLERGNSGL-GFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282
Query: 658 STVGMSHSALVPMLKEQRNKVTLTV 682
++HS V LKE + V L V
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYV 307
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 92.4 bits (228), Expect = 1e-18
Identities = 122/522 (23%), Positives = 208/522 (39%), Gaps = 76/522 (14%)
Query: 224 LSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLIN--IVIQEVYRDGVIARDGRLLAGD 281
+S PE EIT + + + Y LG I+GG + ++ I I V G DG L GD
Sbjct: 893 VSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 951
Query: 282 QILQVNNYNISNVSHNYA-----------RAVLSQPCNTLHLTVLRERRFGNRAHNHSDS 330
+++ VN+ ++ VSH+ A V+SQP + N N+
Sbjct: 952 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1011
Query: 331 NSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILD-LLEGGLAAQDGRLSSNDRVLA 389
+S ++ A+ +R E L EG L++QD R S +
Sbjct: 1012 SSYMQDS---AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQS 1068
Query: 390 -ING-----------HDLKYGTPELAAQIIQASGERVNLTIARPGKPQP----------- 426
+NG + ++G+P + +I + E+ T + K +
Sbjct: 1069 QVNGFFASHLGDQTWQESQHGSP--SPSVISKATEKETFTDSNQSKTKKPGISDVTDYSD 1126
Query: 427 -GNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEK--------HITVKKEPHE 477
G++ + +SSS H TP S + + T + + K +
Sbjct: 1127 RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN- 1185
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
SLG++V GG + I+V +V P G DGRI +GD +L +NG+ L +H +AV
Sbjct: 1186 SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1245
Query: 538 MLKASAASPAVALKALE-------VQIVEEAT---QNAEEQ-PSTFSENEYDASWSPSWV 586
L+ + + L+ + V + + T QNA+ Q P + +S
Sbjct: 1246 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS---- 1301
Query: 587 MWLGLPSTLHSCHDIVLRRSYLG-SWGFSIVGGYEENHTNQPFF-IKTIVLGTPAYYDGR 644
T + ++ L ++ G + FS N +K + G PA G+
Sbjct: 1302 -----FVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1356
Query: 645 LKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
+ GD+I+ VNG S G+S ++ L+ +V L ++C P
Sbjct: 1357 IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL-LLCRP 1397
Score = 61.6 bits (148), Expect = 2e-09
Identities = 64/273 (23%), Positives = 110/273 (40%), Gaps = 59/273 (21%)
Query: 198 STWSEEPGLDNPAFEESAGADTTQQ------PLSLPE-GEITTIEIHRSNPYIQLGISIV 250
+T+S P E S+ +T+ + S P+ G+I +E+ +++ LGIS+
Sbjct: 1135 ATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN--SLGISVT 1192
Query: 251 GGNETPLIN--IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCN 308
GG T + + I ++ V G DGR+ GD++L VN ++ +H A L
Sbjct: 1193 GGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1252
Query: 309 TLHLTVLRERRFGNRAH-------NHSDSNS--------------------PREEIFQVA 341
+HL + + + ++ H SD N+ E F+V
Sbjct: 1253 VVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK 1312
Query: 342 LHKRDSG-------------EQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVL 388
L K SG EQ+ +VR + L G AA+ G++ D +L
Sbjct: 1313 LFKNSSGLGFSFSREDNLIPEQINASIVR--------VKKLFPGQPAAESGKIDVGDVIL 1364
Query: 389 AINGHDLKYGTPELAAQIIQASGERVNLTIARP 421
+NG LK + + ++ + V L + RP
Sbjct: 1365 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1397
Score = 57.4 bits (137), Expect = 4e-08
Identities = 66/258 (25%), Positives = 111/258 (43%), Gaps = 58/258 (22%)
Query: 421 PGKPQPGNTIR---EAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKH--------- 468
P PG + + E+ + SS ++H + S P+ ++ T E H
Sbjct: 1538 PPDMAPGQSYQPQSESASSSSMDKYHIH--HISEPTRQENWTPLKNDLENHLEDFELEVE 1595
Query: 469 --ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
IT+ K SLG TV G + + +V V + DGR+K GD L+ +N D
Sbjct: 1596 LLITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTD 1650
Query: 527 LTNLSHSEAVAMLKASAASPAVAL-KALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
+TN++H++AV +L+A++ + + + + LE+
Sbjct: 1651 VTNMTHTDAVNLLRAASKTVRLVIGRVLELP----------------------------- 1681
Query: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRL 645
+P H DI L + GFS+ GG++ + Q +I I + A +G L
Sbjct: 1682 ----RIPMLPHLLPDITLTCN-KEELGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNL 1734
Query: 646 KCGDMIVAVNGLSTVGMS 663
+ D+I VNG+ST GM+
Sbjct: 1735 QLLDVIHYVNGVSTQGMT 1752
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/275 (22%), Positives = 114/275 (41%), Gaps = 47/275 (17%)
Query: 303 LSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP 362
+S+P + T L+ N NH + E+ + L K + G LG + +
Sbjct: 1567 ISEPTRQENWTPLK-----NDLENHLEDFELEVELL-ITLIKSEKGS-LGFTVTKGNQRI 1619
Query: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
G ++ D+++ A DGRL DR++ +N D+ T A +++A+ + V L I R
Sbjct: 1620 GCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR-- 1676
Query: 423 KPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMT 482
+ E P P D+T +TC + E LG +
Sbjct: 1677 -------VLEL------------PRIPMLPHLLPDIT--LTCNK----------EELGFS 1705
Query: 483 VAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
+ GG S ++++ + P A +G ++ DV+ +NG+ ++ E L S
Sbjct: 1706 LCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS 1763
Query: 543 AASPAVALKAL--EVQIVEEATQNAEEQPSTFSEN 575
P++ LKA ++ +V + ++A P + N
Sbjct: 1764 L--PSLVLKATRNDLPVVPSSKRSAVSAPKSTKGN 1796
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/202 (25%), Positives = 88/202 (43%), Gaps = 20/202 (9%)
Query: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLS 304
LG ++ GN+ I + +V +D + DGRL GD++++VN+ +++N++H A +L
Sbjct: 1608 LGFTVTKGNQR--IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1664
Query: 305 QPCNTLHLT---VLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDE 361
T+ L VL R H D + +K E+LG L D
Sbjct: 1665 AASKTVRLVIGRVLELPRIPMLPHLLPD--------ITLTCNK----EELGFSLCGGHDS 1712
Query: 362 --PGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA 419
V+I D+ +AA +G L D + +NG + T E + + S + L
Sbjct: 1713 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1772
Query: 420 RPGKPQPGNTIREAGNHSSSSQ 441
R P ++ R A + S++
Sbjct: 1773 RNDLPVVPSSKRSAVSAPKSTK 1794
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
I L +S GS GF++ G + ++ ++ PA DGRLK GD ++ VN
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQRIGC----YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
Query: 661 GMSHSALVPMLKEQRNKVTLTV 682
M+H+ V +L+ V L +
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVI 1674
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 92.4 bits (228), Expect = 1e-18
Identities = 122/522 (23%), Positives = 208/522 (39%), Gaps = 76/522 (14%)
Query: 224 LSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLIN--IVIQEVYRDGVIARDGRLLAGD 281
+S PE EIT + + + Y LG I+GG + ++ I I V G DG L GD
Sbjct: 1084 VSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1142
Query: 282 QILQVNNYNISNVSHNYA-----------RAVLSQPCNTLHLTVLRERRFGNRAHNHSDS 330
+++ VN+ ++ VSH+ A V+SQP + N N+
Sbjct: 1143 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1202
Query: 331 NSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILD-LLEGGLAAQDGRLSSNDRVLA 389
+S ++ A+ +R E L EG L++QD R S +
Sbjct: 1203 SSYMQDS---AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQS 1259
Query: 390 -ING-----------HDLKYGTPELAAQIIQASGERVNLTIARPGKPQP----------- 426
+NG + ++G+P + +I + E+ T + K +
Sbjct: 1260 QVNGFFASHLGDQTWQESQHGSP--SPSVISKATEKETFTDSNQSKTKKPGISDVTDYSD 1317
Query: 427 -GNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEK--------HITVKKEPHE 477
G++ + +SSS H TP S + + T + + K +
Sbjct: 1318 RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN- 1376
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
SLG++V GG + I+V +V P G DGRI +GD +L +NG+ L +H +AV
Sbjct: 1377 SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1436
Query: 538 MLKASAASPAVALKALE-------VQIVEEAT---QNAEEQ-PSTFSENEYDASWSPSWV 586
L+ + + L+ + V + + T QNA+ Q P + +S
Sbjct: 1437 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS---- 1492
Query: 587 MWLGLPSTLHSCHDIVLRRSYLG-SWGFSIVGGYEENHTNQPFF-IKTIVLGTPAYYDGR 644
T + ++ L ++ G + FS N +K + G PA G+
Sbjct: 1493 -----FVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1547
Query: 645 LKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
+ GD+I+ VNG S G+S ++ L+ +V L ++C P
Sbjct: 1548 IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL-LLCRP 1588
Score = 61.6 bits (148), Expect = 2e-09
Identities = 64/273 (23%), Positives = 110/273 (40%), Gaps = 59/273 (21%)
Query: 198 STWSEEPGLDNPAFEESAGADTTQQ------PLSLPE-GEITTIEIHRSNPYIQLGISIV 250
+T+S P E S+ +T+ + S P+ G+I +E+ +++ LGIS+
Sbjct: 1326 ATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN--SLGISVT 1383
Query: 251 GGNETPLIN--IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCN 308
GG T + + I ++ V G DGR+ GD++L VN ++ +H A L
Sbjct: 1384 GGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1443
Query: 309 TLHLTVLRERRFGNRAH-------NHSDSNS--------------------PREEIFQVA 341
+HL + + + ++ H SD N+ E F+V
Sbjct: 1444 VVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK 1503
Query: 342 LHKRDSG-------------EQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVL 388
L K SG EQ+ +VR + L G AA+ G++ D +L
Sbjct: 1504 LFKNSSGLGFSFSREDNLIPEQINASIVR--------VKKLFPGQPAAESGKIDVGDVIL 1555
Query: 389 AINGHDLKYGTPELAAQIIQASGERVNLTIARP 421
+NG LK + + ++ + V L + RP
Sbjct: 1556 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1588
Score = 57.4 bits (137), Expect = 4e-08
Identities = 66/258 (25%), Positives = 111/258 (43%), Gaps = 58/258 (22%)
Query: 421 PGKPQPGNTIR---EAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKH--------- 468
P PG + + E+ + SS ++H + S P+ ++ T E H
Sbjct: 1729 PPDMAPGQSYQPQSESASSSSMDKYHIH--HISEPTRQENWTPLKNDLENHLEDFELEVE 1786
Query: 469 --ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
IT+ K SLG TV G + + +V V + DGR+K GD L+ +N D
Sbjct: 1787 LLITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTD 1841
Query: 527 LTNLSHSEAVAMLKASAASPAVAL-KALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
+TN++H++AV +L+A++ + + + + LE+
Sbjct: 1842 VTNMTHTDAVNLLRAASKTVRLVIGRVLELP----------------------------- 1872
Query: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRL 645
+P H DI L + GFS+ GG++ + Q +I I + A +G L
Sbjct: 1873 ----RIPMLPHLLPDITLTCN-KEELGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNL 1925
Query: 646 KCGDMIVAVNGLSTVGMS 663
+ D+I VNG+ST GM+
Sbjct: 1926 QLLDVIHYVNGVSTQGMT 1943
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 10/117 (8%)
Query: 427 GNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITV---KKEPHESLGMTV 483
G T+ +GN SS P HK + V+ E+ IT+ KK+ LG +
Sbjct: 1056 GMTMHSSGNSSSQV------PLKENDVLHKRWS-IVSSPEREITLVNLKKDAKYGLGFQI 1108
Query: 484 AGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
GG +L IF++SV P G DG +K GD L+++N + L +SH A+ +L+
Sbjct: 1109 IGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQ 1165
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/275 (22%), Positives = 114/275 (41%), Gaps = 47/275 (17%)
Query: 303 LSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP 362
+S+P + T L+ N NH + E+ + L K + G LG + +
Sbjct: 1758 ISEPTRQENWTPLK-----NDLENHLEDFELEVELL-ITLIKSEKGS-LGFTVTKGNQRI 1810
Query: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
G ++ D+++ A DGRL DR++ +N D+ T A +++A+ + V L I R
Sbjct: 1811 GCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR-- 1867
Query: 423 KPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMT 482
+ E P P D+T +TC + E LG +
Sbjct: 1868 -------VLEL------------PRIPMLPHLLPDIT--LTCNK----------EELGFS 1896
Query: 483 VAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
+ GG S ++++ + P A +G ++ DV+ +NG+ ++ E L S
Sbjct: 1897 LCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS 1954
Query: 543 AASPAVALKAL--EVQIVEEATQNAEEQPSTFSEN 575
P++ LKA ++ +V + ++A P + N
Sbjct: 1955 L--PSLVLKATRNDLPVVPSSKRSAVSAPKSTKGN 1987
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/202 (25%), Positives = 88/202 (43%), Gaps = 20/202 (9%)
Query: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLS 304
LG ++ GN+ I + +V +D + DGRL GD++++VN+ +++N++H A +L
Sbjct: 1799 LGFTVTKGNQR--IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1855
Query: 305 QPCNTLHLT---VLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDE 361
T+ L VL R H D + +K E+LG L D
Sbjct: 1856 AASKTVRLVIGRVLELPRIPMLPHLLPD--------ITLTCNK----EELGFSLCGGHDS 1903
Query: 362 --PGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA 419
V+I D+ +AA +G L D + +NG + T E + + S + L
Sbjct: 1904 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1963
Query: 420 RPGKPQPGNTIREAGNHSSSSQ 441
R P ++ R A + S++
Sbjct: 1964 RNDLPVVPSSKRSAVSAPKSTK 1985
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
I L +S GS GF++ G + ++ ++ PA DGRLK GD ++ VN
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQRIGC----YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843
Query: 661 GMSHSALVPMLKEQRNKVTLTV 682
M+H+ V +L+ V L +
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVI 1865
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 92.4 bits (228), Expect = 1e-18
Identities = 122/522 (23%), Positives = 208/522 (39%), Gaps = 76/522 (14%)
Query: 224 LSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLIN--IVIQEVYRDGVIARDGRLLAGD 281
+S PE EIT + + + Y LG I+GG + ++ I I V G DG L GD
Sbjct: 1065 VSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1123
Query: 282 QILQVNNYNISNVSHNYA-----------RAVLSQPCNTLHLTVLRERRFGNRAHNHSDS 330
+++ VN+ ++ VSH+ A V+SQP + N N+
Sbjct: 1124 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1183
Query: 331 NSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILD-LLEGGLAAQDGRLSSNDRVLA 389
+S ++ A+ +R E L EG L++QD R S +
Sbjct: 1184 SSYMQDS---AIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQS 1240
Query: 390 -ING-----------HDLKYGTPELAAQIIQASGERVNLTIARPGKPQP----------- 426
+NG + ++G+P + +I + E+ T + K +
Sbjct: 1241 QVNGFFASHLGDQTWQESQHGSP--SPSVISKATEKETFTDSNQSKTKKPGISDVTDYSD 1298
Query: 427 -GNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEK--------HITVKKEPHE 477
G++ + +SSS H TP S + + T + + K +
Sbjct: 1299 RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN- 1357
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
SLG++V GG + I+V +V P G DGRI +GD +L +NG+ L +H +AV
Sbjct: 1358 SLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVE 1417
Query: 538 MLKASAASPAVALKALE-------VQIVEEAT---QNAEEQ-PSTFSENEYDASWSPSWV 586
L+ + + L+ + V + + T QNA+ Q P + +S
Sbjct: 1418 TLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS---- 1473
Query: 587 MWLGLPSTLHSCHDIVLRRSYLG-SWGFSIVGGYEENHTNQPFF-IKTIVLGTPAYYDGR 644
T + ++ L ++ G + FS N +K + G PA G+
Sbjct: 1474 -----FVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1528
Query: 645 LKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
+ GD+I+ VNG S G+S ++ L+ +V L ++C P
Sbjct: 1529 IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL-LLCRP 1569
Score = 61.6 bits (148), Expect = 2e-09
Identities = 64/273 (23%), Positives = 110/273 (40%), Gaps = 59/273 (21%)
Query: 198 STWSEEPGLDNPAFEESAGADTTQQ------PLSLPE-GEITTIEIHRSNPYIQLGISIV 250
+T+S P E S+ +T+ + S P+ G+I +E+ +++ LGIS+
Sbjct: 1307 ATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN--SLGISVT 1364
Query: 251 GGNETPLIN--IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCN 308
GG T + + I ++ V G DGR+ GD++L VN ++ +H A L
Sbjct: 1365 GGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1424
Query: 309 TLHLTVLRERRFGNRAH-------NHSDSNS--------------------PREEIFQVA 341
+HL + + + ++ H SD N+ E F+V
Sbjct: 1425 VVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK 1484
Query: 342 LHKRDSG-------------EQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVL 388
L K SG EQ+ +VR + L G AA+ G++ D +L
Sbjct: 1485 LFKNSSGLGFSFSREDNLIPEQINASIVR--------VKKLFPGQPAAESGKIDVGDVIL 1536
Query: 389 AINGHDLKYGTPELAAQIIQASGERVNLTIARP 421
+NG LK + + ++ + V L + RP
Sbjct: 1537 KVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1569
Score = 57.4 bits (137), Expect = 4e-08
Identities = 66/258 (25%), Positives = 111/258 (43%), Gaps = 58/258 (22%)
Query: 421 PGKPQPGNTIR---EAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKH--------- 468
P PG + + E+ + SS ++H + S P+ ++ T E H
Sbjct: 1710 PPDMAPGQSYQPQSESASSSSMDKYHIH--HISEPTRQENWTPLKNDLENHLEDFELEVE 1767
Query: 469 --ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
IT+ K SLG TV G + + +V V + DGR+K GD L+ +N D
Sbjct: 1768 LLITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTD 1822
Query: 527 LTNLSHSEAVAMLKASAASPAVAL-KALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
+TN++H++AV +L+A++ + + + + LE+
Sbjct: 1823 VTNMTHTDAVNLLRAASKTVRLVIGRVLELP----------------------------- 1853
Query: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRL 645
+P H DI L + GFS+ GG++ + Q +I I + A +G L
Sbjct: 1854 ----RIPMLPHLLPDITLTCN-KEELGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNL 1906
Query: 646 KCGDMIVAVNGLSTVGMS 663
+ D+I VNG+ST GM+
Sbjct: 1907 QLLDVIHYVNGVSTQGMT 1924
Score = 54.3 bits (129), Expect = 4e-07
Identities = 36/109 (33%), Positives = 55/109 (50%), Gaps = 4/109 (3%)
Query: 435 NHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITV---KKEPHESLGMTVAGGRGSKS 491
+ S SS P Y HK + V+ E+ IT+ KK+ LG + GG
Sbjct: 1039 HESDSSSIEDPGQAYVLDVLHKRWS-IVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGR 1097
Query: 492 GELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
+L IF++SV P G DG +K GD L+++N + L +SH A+ +L+
Sbjct: 1098 LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQ 1146
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/275 (22%), Positives = 114/275 (41%), Gaps = 47/275 (17%)
Query: 303 LSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP 362
+S+P + T L+ N NH + E+ + L K + G LG + +
Sbjct: 1739 ISEPTRQENWTPLK-----NDLENHLEDFELEVELL-ITLIKSEKGS-LGFTVTKGNQRI 1791
Query: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
G ++ D+++ A DGRL DR++ +N D+ T A +++A+ + V L I R
Sbjct: 1792 GCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR-- 1848
Query: 423 KPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMT 482
+ E P P D+T +TC + E LG +
Sbjct: 1849 -------VLEL------------PRIPMLPHLLPDIT--LTCNK----------EELGFS 1877
Query: 483 VAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
+ GG S ++++ + P A +G ++ DV+ +NG+ ++ E L S
Sbjct: 1878 LCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS 1935
Query: 543 AASPAVALKAL--EVQIVEEATQNAEEQPSTFSEN 575
P++ LKA ++ +V + ++A P + N
Sbjct: 1936 L--PSLVLKATRNDLPVVPSSKRSAVSAPKSTKGN 1968
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/202 (25%), Positives = 88/202 (43%), Gaps = 20/202 (9%)
Query: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLS 304
LG ++ GN+ I + +V +D + DGRL GD++++VN+ +++N++H A +L
Sbjct: 1780 LGFTVTKGNQR--IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1836
Query: 305 QPCNTLHLT---VLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDE 361
T+ L VL R H D + +K E+LG L D
Sbjct: 1837 AASKTVRLVIGRVLELPRIPMLPHLLPD--------ITLTCNK----EELGFSLCGGHDS 1884
Query: 362 --PGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA 419
V+I D+ +AA +G L D + +NG + T E + + S + L
Sbjct: 1885 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1944
Query: 420 RPGKPQPGNTIREAGNHSSSSQ 441
R P ++ R A + S++
Sbjct: 1945 RNDLPVVPSSKRSAVSAPKSTK 1966
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
I L +S GS GF++ G + ++ ++ PA DGRLK GD ++ VN
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQRIGC----YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 661 GMSHSALVPMLKEQRNKVTLTV 682
M+H+ V +L+ V L +
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVI 1846
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 92.4 bits (228), Expect = 1e-18
Identities = 126/512 (24%), Positives = 204/512 (39%), Gaps = 92/512 (17%)
Query: 222 QPLSLPEGEITTIEIHRSNPYIQLGISIVGGN-ETPLIN----IVIQEVYRDGVIARDGR 276
+P + E E+T + ++ LGISI GG TP I I V +G AR G
Sbjct: 718 EPARIEEEELTLTILRQTGG---LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG- 773
Query: 277 LLAGDQILQVNNYNISNVSHNYA----------------RAVLSQPCNTLHLTVLR---- 316
+ GD++L+VN + H+ A R + +P N + +T LR
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDD 833
Query: 317 ----ERRFGNRAHN--HSDSNSPREEIFQVALHKRDSGEQLGIKLVR-------RTDEPG 363
ERR G +S P + L + + G LG + R + G
Sbjct: 834 YSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERG--LGFSIAGGKGSTPYRAGDAG 891
Query: 364 VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR--- 420
+F+ + EGG A + G L DRVL+ING D+ + A ++ A+ + L + R
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG 951
Query: 421 ---PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHE 477
P P P ++ A ++S T P PS L + + P
Sbjct: 952 GPLPPSPLPHSSPPTAAVATTSITTAT-PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA 1010
Query: 478 S--LGMTVAGGRGSKS-----GELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNL 530
LG+++ GG S E +F++ V P G AR G ++ GD +L +NG D+ +
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDA 1069
Query: 531 SHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLG 590
+H EAV+ L P + L L P+ E +P + +
Sbjct: 1070 THQEAVSAL----LRPCLELSLL-----------VRRDPAPPGLRELCIQKAPGERLGIS 1114
Query: 591 LPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650
+ G+ G + G + T++ FI + A DGRL+ G
Sbjct: 1115 IRG---------------GARGHA---GNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLR 1156
Query: 651 IVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
++ VN S +G++H V +L+ + +T+ V
Sbjct: 1157 LLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 92.4 bits (228), Expect = 1e-18
Identities = 126/512 (24%), Positives = 204/512 (39%), Gaps = 92/512 (17%)
Query: 222 QPLSLPEGEITTIEIHRSNPYIQLGISIVGGN-ETPLIN----IVIQEVYRDGVIARDGR 276
+P + E E+T + ++ LGISI GG TP I I V +G AR G
Sbjct: 718 EPARIEEEELTLTILRQTGG---LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG- 773
Query: 277 LLAGDQILQVNNYNISNVSHNYA----------------RAVLSQPCNTLHLTVLR---- 316
+ GD++L+VN + H+ A R + +P N + +T LR
Sbjct: 774 VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDD 833
Query: 317 ----ERRFGNRAHN--HSDSNSPREEIFQVALHKRDSGEQLGIKLVR-------RTDEPG 363
ERR G +S P + L + + G LG + R + G
Sbjct: 834 YSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERG--LGFSIAGGKGSTPYRAGDAG 891
Query: 364 VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR--- 420
+F+ + EGG A + G L DRVL+ING D+ + A ++ A+ + L + R
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAG 951
Query: 421 ---PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHE 477
P P P ++ A ++S T P PS L + + P
Sbjct: 952 GPLPPSPLPHSSPPTAAVATTSITTAT-PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA 1010
Query: 478 S--LGMTVAGGRGSKS-----GELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNL 530
LG+++ GG S E +F++ V P G AR G ++ GD +L +NG D+ +
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDA 1069
Query: 531 SHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLG 590
+H EAV+ L P + L L P+ E +P + +
Sbjct: 1070 THQEAVSAL----LRPCLELSLL-----------VRRDPAPPGLRELCIQKAPGERLGIS 1114
Query: 591 LPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650
+ G+ G + G + T++ FI + A DGRL+ G
Sbjct: 1115 IRG---------------GARGHA---GNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLR 1156
Query: 651 IVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
++ VN S +G++H V +L+ + +T+ V
Sbjct: 1157 LLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 86.3 bits (212), Expect = 9e-17
Identities = 122/527 (23%), Positives = 208/527 (39%), Gaps = 81/527 (15%)
Query: 224 LSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLIN--IVIQEVYRDGVIARDGRLLAGD 281
+S PE EIT + + + Y LG I+GG + ++ I I V G DG L GD
Sbjct: 1084 VSSPEREITLVNLKKDAKY-GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGD 1142
Query: 282 QILQVNNYNISNVSHNYA-----------RAVLSQPCNTLHLTVLRERRFGNRAHNHSDS 330
+++ VN+ ++ VSH+ A V+SQP + N N+
Sbjct: 1143 RLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKK 1202
Query: 331 NSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFIL-DLLEGGLAAQDGRLSSNDRVLA 389
+S ++ A+ +R E L EG L++QD R S +
Sbjct: 1203 SSYMQD---SAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQS 1259
Query: 390 -ING-----------HDLKYGTPELAAQIIQASGERVNLTIARPGKPQP----------- 426
+NG + ++G+P + +I + E+ T + K +
Sbjct: 1260 QVNGFFASHLGDQTWQESQHGSP--SPSVISKATEKETFTDSNQSKTKKPGISDVTDYSD 1317
Query: 427 -GNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEK--------HITVKKEPHE 477
G++ + +SSS H TP S + + T + + K +
Sbjct: 1318 RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDN- 1376
Query: 478 SLGMTVA-----GGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSH 532
SLG++V GG + I+V +V P G DGRI +GD +L +NG+ L +H
Sbjct: 1377 SLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATH 1436
Query: 533 SEAVAMLKASAASPAVALKALE-------VQIVEEAT---QNAEEQ-PSTFSENEYDASW 581
+AV L+ + + L+ + V + + T QNA+ Q P + +
Sbjct: 1437 KQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDY 1496
Query: 582 SPSWVMWLGLPSTLHSCHDIVLRRSYLG-SWGFSIVGGYEENHTNQPFF-IKTIVLGTPA 639
S T + ++ L ++ G + FS N +K + G PA
Sbjct: 1497 S---------FVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547
Query: 640 YYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
G++ GD+I+ VNG S G+S ++ L+ +V L ++C P
Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL-LLCRP 1593
Score = 57.4 bits (137), Expect = 4e-08
Identities = 66/258 (25%), Positives = 111/258 (43%), Gaps = 58/258 (22%)
Query: 421 PGKPQPGNTIR---EAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKH--------- 468
P PG + + E+ + SS ++H + S P+ ++ T E H
Sbjct: 1734 PPDMAPGQSYQPQSESASSSSMDKYHIH--HISEPTRQENWTPLKNDLENHLEDFELEVE 1791
Query: 469 --ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
IT+ K SLG TV G + + +V V + DGR+K GD L+ +N D
Sbjct: 1792 LLITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTD 1846
Query: 527 LTNLSHSEAVAMLKASAASPAVAL-KALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
+TN++H++AV +L+A++ + + + + LE+
Sbjct: 1847 VTNMTHTDAVNLLRAASKTVRLVIGRVLELP----------------------------- 1877
Query: 586 VMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRL 645
+P H DI L + GFS+ GG++ + Q +I I + A +G L
Sbjct: 1878 ----RIPMLPHLLPDITLTCN-KEELGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNL 1930
Query: 646 KCGDMIVAVNGLSTVGMS 663
+ D+I VNG+ST GM+
Sbjct: 1931 QLLDVIHYVNGVSTQGMT 1948
Score = 56.2 bits (134), Expect = 1e-07
Identities = 60/276 (21%), Positives = 111/276 (40%), Gaps = 60/276 (21%)
Query: 198 STWSEEPGLDNPAFEESAGADTTQQ------PLSLPE-GEITTIEIHRSNPYIQLGISIV 250
+T+S P E S+ +T+ + S P+ G+I +E+ +++ + + ++++
Sbjct: 1326 ATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVL 1385
Query: 251 ---GGNETPLIN--IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
GG T + + I ++ V G DGR+ GD++L VN ++ +H A L
Sbjct: 1386 FDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN 1445
Query: 306 PCNTLHLTVLRERRFGNRAH-------NHSDSNS--------------------PREEIF 338
+HL + + + ++ H SD N+ E F
Sbjct: 1446 TGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTF 1505
Query: 339 QVALHKRDSG-------------EQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSND 385
+V L K SG EQ+ +VR + L G AA+ G++ D
Sbjct: 1506 EVKLFKNSSGLGFSFSREDNLIPEQINASIVR--------VKKLFPGQPAAESGKIDVGD 1557
Query: 386 RVLAINGHDLKYGTPELAAQIIQASGERVNLTIARP 421
+L +NG LK + + ++ + V L + RP
Sbjct: 1558 VILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRP 1593
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/117 (32%), Positives = 58/117 (49%), Gaps = 10/117 (8%)
Query: 427 GNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITV---KKEPHESLGMTV 483
G T+ +GN SS P HK + V+ E+ IT+ KK+ LG +
Sbjct: 1056 GMTMHSSGNSSSQV------PLKENDVLHKRWS-IVSSPEREITLVNLKKDAKYGLGFQI 1108
Query: 484 AGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
GG +L IF++SV P G DG +K GD L+++N + L +SH A+ +L+
Sbjct: 1109 IGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQ 1165
Score = 52.8 bits (125), Expect = 1e-06
Identities = 62/275 (22%), Positives = 114/275 (41%), Gaps = 47/275 (17%)
Query: 303 LSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP 362
+S+P + T L+ N NH + E+ + L K + G LG + +
Sbjct: 1763 ISEPTRQENWTPLK-----NDLENHLEDFELEVELL-ITLIKSEKGS-LGFTVTKGNQRI 1815
Query: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
G ++ D+++ A DGRL DR++ +N D+ T A +++A+ + V L I R
Sbjct: 1816 GCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR-- 1872
Query: 423 KPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMT 482
+ E P P D+T +TC + E LG +
Sbjct: 1873 -------VLEL------------PRIPMLPHLLPDIT--LTCNK----------EELGFS 1901
Query: 483 VAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
+ GG S ++++ + P A +G ++ DV+ +NG+ ++ E L S
Sbjct: 1902 LCGGHDSL--YQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMS 1959
Query: 543 AASPAVALKAL--EVQIVEEATQNAEEQPSTFSEN 575
P++ LKA ++ +V + ++A P + N
Sbjct: 1960 L--PSLVLKATRNDLPVVPSSKRSAVSAPKSTKGN 1992
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/202 (25%), Positives = 88/202 (43%), Gaps = 20/202 (9%)
Query: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLS 304
LG ++ GN+ I + +V +D + DGRL GD++++VN+ +++N++H A +L
Sbjct: 1804 LGFTVTKGNQR--IGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLR 1860
Query: 305 QPCNTLHLT---VLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDE 361
T+ L VL R H D + +K E+LG L D
Sbjct: 1861 AASKTVRLVIGRVLELPRIPMLPHLLPD--------ITLTCNK----EELGFSLCGGHDS 1908
Query: 362 --PGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA 419
V+I D+ +AA +G L D + +NG + T E + + S + L
Sbjct: 1909 LYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKAT 1968
Query: 420 RPGKPQPGNTIREAGNHSSSSQ 441
R P ++ R A + S++
Sbjct: 1969 RNDLPVVPSSKRSAVSAPKSTK 1990
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/82 (30%), Positives = 40/82 (48%), Gaps = 5/82 (6%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
I L +S GS GF++ G + ++ ++ PA DGRLK GD ++ VN
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQRIGC----YVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848
Query: 661 GMSHSALVPMLKEQRNKVTLTV 682
M+H+ V +L+ V L +
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVI 1870
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 86.3 bits (212), Expect = 9e-17
Identities = 95/392 (24%), Positives = 156/392 (39%), Gaps = 72/392 (18%)
Query: 346 DSGEQLGIKLV----RRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLK----- 396
+ G LGI +V R G+ + L +GG A + ND ++ IN DL+
Sbjct: 279 NDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFE 338
Query: 397 ---------YGTPELAAQIIQASGERVNLTIARPGKPQ-------------PGNTIREAG 434
TP + ++ A+ + +++ K ++ AG
Sbjct: 339 QAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAG 398
Query: 435 NH----------------SSSSQHHTPPPYYSRPSSHKDLTQCV---TCQEKHITVK--- 472
H S S H+ P PS+ Q V T + T K
Sbjct: 399 LHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGK 458
Query: 473 ------KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGID 526
K+ E LG ++ + G PI+V ++ P G +DGR+K GD L+ +NG+D
Sbjct: 459 RLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
Query: 527 LTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQ-NAE----EQPSTFSENEYDASW 581
L S E V++L+++ V+L + + NAE + P + D
Sbjct: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVL 578
Query: 582 SPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGG-YEENHTNQPFFIKTIVLGTPAY 640
+P G L ++ L S G S+ G +ENH + F+K+I+ G A
Sbjct: 579 TPD-----GTREFL--TFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
Query: 641 YDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 672
DGRL+ D ++AVNG S +G ++ + L+
Sbjct: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
Score = 59.7 bits (143), Expect = 9e-09
Identities = 51/208 (24%), Positives = 99/208 (47%), Gaps = 19/208 (9%)
Query: 349 EQLGIKLVRRTDEPG----VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAA 404
E LG + R G +++ ++L G A QDGRL + DR++ +NG DL + E
Sbjct: 469 EGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVV 528
Query: 405 QIIQASGER--VNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCV 462
+++++ V+L + R + ++ SQ P + +D+
Sbjct: 529 SLLRSTKMEGTVSLLVFRQE-----DAFHPRELNAEPSQMQIPK---ETKAEDEDIVLTP 580
Query: 463 TCQEKHITVKKEPHES----LGMTVAGGRGSKS-GELPIFVTSVPPHGCLARDGRIKRGD 517
+ +T + ++S LG++V G R ++ +L IFV S+ G ++DGR++ D
Sbjct: 581 DGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVND 640
Query: 518 VLLNINGIDLTNLSHSEAVAMLKASAAS 545
L+ +NG L ++ +A+ L+ S ++
Sbjct: 641 QLIAVNGESLLGKTNQDAMETLRRSMST 668
Score = 55.5 bits (132), Expect = 2e-07
Identities = 56/200 (28%), Positives = 91/200 (45%), Gaps = 39/200 (19%)
Query: 245 LGISIVG-----GNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYA 299
LG SI G P I ++ + G +DGRL AGD++++VN ++ S
Sbjct: 471 LGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEV 527
Query: 300 RAVL--SQPCNTLHLTVLR-ERRFGNRAHNHSDSNS--PREE------------------ 336
++L ++ T+ L V R E F R N S P+E
Sbjct: 528 VSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFL 587
Query: 337 IFQVALHKRDSGEQ-LGIKLVRRTDEP-----GVFILDLLEGGLAAQDGRLSSNDRVLAI 390
F+V L+ DSG LG+ + + G+F+ ++ GG A++DGRL ND+++A+
Sbjct: 588 TFEVPLN--DSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAV 645
Query: 391 NGHDLKYGTPELAAQIIQAS 410
NG L T + A + ++ S
Sbjct: 646 NGESLLGKTNQDAMETLRRS 665
Score = 47.0 bits (110), Expect = 6e-05
Identities = 24/72 (33%), Positives = 40/72 (55%)
Query: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
GFSI + P ++K I+ A DGRLK GD ++ VNG+ VG S +V +L
Sbjct: 472 GFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLL 531
Query: 672 KEQRNKVTLTVI 683
+ + + T++++
Sbjct: 532 RSTKMEGTVSLL 543
Score = 32.3 bits (72), Expect = 1.5
Identities = 17/68 (25%), Positives = 33/68 (48%), Gaps = 3/68 (4%)
Query: 245 LGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARA 301
LG+S+ G + I ++ + G ++DGRL DQ++ VN ++ ++ A
Sbjct: 601 LGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAME 660
Query: 302 VLSQPCNT 309
L + +T
Sbjct: 661 TLRRSMST 668
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 86.3 bits (212), Expect = 9e-17
Identities = 104/410 (25%), Positives = 174/410 (42%), Gaps = 68/410 (16%)
Query: 333 PREEIFQVALHKRDSGEQLGIKL----VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVL 388
P EI +V L KRD G + +PG+FI ++ GG A + + ++L
Sbjct: 747 PGREIVRVTL-KRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQIL 805
Query: 389 AINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQ------- 441
A+N L+ T +A ++IQ S + + L I++ K GN E N +++S
Sbjct: 806 ALNHISLEGFTFNMAVRMIQNSPDNIELIISQ-SKGVGGNNPDEEKNSTANSGVSSTDIL 864
Query: 442 ---------HHTPP---------------------------PYYSRPSSHKDLTQCVTCQ 465
HT P SS ++
Sbjct: 865 SFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAG 924
Query: 466 EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGI 525
E + + +LG +V GG + I+V S+ P G A++G+I +GD LL ++G+
Sbjct: 925 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
Query: 526 DLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
L L+H +AV L + ++E + +Q + +++ D + S
Sbjct: 985 ILCGLTHKQAVQCLTGPGQVARL--------VLERRVPRSTQQCPSANDSMGDERTAVSL 1036
Query: 586 VMWL-GLPSTLHSCHD-----IVLRRSYLGSWGFSIVGGYEE--NHTNQPFF-IKTIVLG 636
V L G PS+ S D + L+++ G GFS V +E +H IK + G
Sbjct: 1037 VTALPGRPSSCVSVTDGPKFEVKLKKNANG-LGFSFVQMEKESCSHLKSDLVRIKRLFPG 1095
Query: 637 TPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
PA +G + GD+I+AVNG ST G+ ++ +L+ +VTL ++C P
Sbjct: 1096 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL-LLCRP 1144
Score = 58.5 bits (140), Expect = 2e-08
Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 36/241 (14%)
Query: 213 ESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNET--PLINIVIQEVYRDGV 270
+ AG+ P + GEI +E+ + + LG S+ GG T P I ++ + G
Sbjct: 908 KGAGSSCPPSPPEISAGEIYFVELVKEDG--TLGFSVTGGINTSVPYGGIYVKSIVPGGP 965
Query: 271 IARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRE-RRFGNRAHNHSD 329
A++G++L GD++LQV+ + ++H A L+ P L + R R + + +D
Sbjct: 966 AAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSAND 1025
Query: 330 SNSPREEI----------------------FQVALHKRDSGEQLGIKLVRRTDEPG---- 363
S F+V L K +G LG V+ E
Sbjct: 1026 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG--LGFSFVQMEKESCSHLK 1083
Query: 364 ---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
V I L G A ++G +++ D +LA+NG + + +++ + + V L + R
Sbjct: 1084 SDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1143
Query: 421 P 421
P
Sbjct: 1144 P 1144
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 86.3 bits (212), Expect = 9e-17
Identities = 104/410 (25%), Positives = 174/410 (42%), Gaps = 68/410 (16%)
Query: 333 PREEIFQVALHKRDSGEQLGIKL----VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVL 388
P EI +V L KRD G + +PG+FI ++ GG A + + ++L
Sbjct: 769 PGREIVRVTL-KRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQIL 827
Query: 389 AINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQ------- 441
A+N L+ T +A ++IQ S + + L I++ K GN E N +++S
Sbjct: 828 ALNHISLEGFTFNMAVRMIQNSPDNIELIISQ-SKGVGGNNPDEEKNSTANSGVSSTDIL 886
Query: 442 ---------HHTPP---------------------------PYYSRPSSHKDLTQCVTCQ 465
HT P SS ++
Sbjct: 887 SFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAG 946
Query: 466 EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGI 525
E + + +LG +V GG + I+V S+ P G A++G+I +GD LL ++G+
Sbjct: 947 EIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 1006
Query: 526 DLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSW 585
L L+H +AV L + ++E + +Q + +++ D + S
Sbjct: 1007 ILCGLTHKQAVQCLTGPGQVARL--------VLERRVPRSTQQCPSANDSMGDERTAVSL 1058
Query: 586 VMWL-GLPSTLHSCHD-----IVLRRSYLGSWGFSIVGGYEE--NHTNQPFF-IKTIVLG 636
V L G PS+ S D + L+++ G GFS V +E +H IK + G
Sbjct: 1059 VTALPGRPSSCVSVTDGPKFEVKLKKNANG-LGFSFVQMEKESCSHLKSDLVRIKRLFPG 1117
Query: 637 TPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVICWP 686
PA +G + GD+I+AVNG ST G+ ++ +L+ +VTL ++C P
Sbjct: 1118 QPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTL-LLCRP 1166
Score = 58.5 bits (140), Expect = 2e-08
Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 36/241 (14%)
Query: 213 ESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNET--PLINIVIQEVYRDGV 270
+ AG+ P + GEI +E+ + + LG S+ GG T P I ++ + G
Sbjct: 930 KGAGSSCPPSPPEISAGEIYFVELVKEDG--TLGFSVTGGINTSVPYGGIYVKSIVPGGP 987
Query: 271 IARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRE-RRFGNRAHNHSD 329
A++G++L GD++LQV+ + ++H A L+ P L + R R + + +D
Sbjct: 988 AAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSAND 1047
Query: 330 SNSPREEI----------------------FQVALHKRDSGEQLGIKLVRRTDEPG---- 363
S F+V L K +G LG V+ E
Sbjct: 1048 SMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG--LGFSFVQMEKESCSHLK 1105
Query: 364 ---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIAR 420
V I L G A ++G +++ D +LA+NG + + +++ + + V L + R
Sbjct: 1106 SDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCR 1165
Query: 421 P 421
P
Sbjct: 1166 P 1166
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 85.1 bits (209), Expect = 2e-16
Identities = 67/205 (32%), Positives = 97/205 (47%), Gaps = 18/205 (8%)
Query: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
I +KK P E LG TV S G PIFV ++ P G +DGR++ GD +L +NG D+T
Sbjct: 384 IDLKKGP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
Query: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588
+ E VAML+++ +L A Q P + E D
Sbjct: 443 GRTQEELVAMLRSTKQGETASLVI--------ARQEGHFLPREL-KGEPDCCA------- 486
Query: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE-ENHTNQPFFIKTIVLGTPAYYDGRLKC 647
L L ++ +I L S G S+ G E T+ FIK+I+ G A+ DGRL+
Sbjct: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
Query: 648 GDMIVAVNGLSTVGMSHSALVPMLK 672
D ++AVNG S +G S+ + L+
Sbjct: 547 NDQLIAVNGESLLGKSNHEAMETLR 571
Score = 70.9 bits (172), Expect = 4e-12
Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 25/211 (11%)
Query: 339 QVALHKRDSGEQLGIKLVRRTDE---PG-VFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394
++ + + E LG +V R PG +F+ ++L G A +DGRL S DR+L +NG D
Sbjct: 381 KIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
Query: 395 LKYGTPELAAQIIQAS--GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452
+ T E +++++ GE +L IAR Q G H P P
Sbjct: 441 VTGRTQEELVAMLRSTKQGETASLVIAR----QEG--------------HFLPRELKGEP 482
Query: 453 SSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG-ELPIFVTSVPPHGCLARDG 511
+ I + LG+++ G + ++G +L IF+ S+ G +DG
Sbjct: 483 DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
Query: 512 RIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
R++ D L+ +NG L S+ EA+ L+ S
Sbjct: 543 RLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
Score = 56.6 bits (135), Expect = 7e-08
Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 17/151 (11%)
Query: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL--SQPCNTLHLTVLRE 317
I ++ + G +DGRL +GD+IL+VN +++ + A+L ++ T L + R+
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 318 ------RRFGNRAHNHSDSNSPREEI-FQVALHKRDSGEQ-LGIKLV----RRTD-EPGV 364
R + S E++ F++ L+ DSG LG+ L R T + G+
Sbjct: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLN--DSGSAGLGVSLKGNKSRETGTDLGI 527
Query: 365 FILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395
FI ++ GG A +DGRL ND+++A+NG L
Sbjct: 528 FIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/253 (22%), Positives = 97/253 (38%), Gaps = 48/253 (18%)
Query: 479 LGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
LG+ V S SG L +F+ + + R+G + ++ IN +DL + + ++A
Sbjct: 213 LGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQD 272
Query: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN---------------------- 575
+ + + SP+V L L Q E+ ++ + F N
Sbjct: 273 VFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTAN 332
Query: 576 -------EYDASWS------------------PSWVMWLGLPSTLHSCHDIVLRRSYLGS 610
E DAS S PS +G S ++ + +
Sbjct: 333 LTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
Query: 611 WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670
GF++V H P F+K I+ A DGRL+ GD I+ VNG G + LV M
Sbjct: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452
Query: 671 LKEQRNKVTLTVI 683
L+ + T +++
Sbjct: 453 LRSTKQGETASLV 465
Score = 33.9 bits (76), Expect = 0.52
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 224 LSLPEGEITTIEIHRSNP-YIQLGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLA 279
LSL E T EI ++ LG+S+ G + I I+ + G +DGRL
Sbjct: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
Query: 280 GDQILQVNNYNISNVSHNYARAVL 303
DQ++ VN ++ S++ A L
Sbjct: 547 NDQLIAVNGESLLGKSNHEAMETL 570
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 85.1 bits (209), Expect = 2e-16
Identities = 67/205 (32%), Positives = 97/205 (47%), Gaps = 18/205 (8%)
Query: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
I +KK P E LG TV S G PIFV ++ P G +DGR++ GD +L +NG D+T
Sbjct: 384 IDLKKGP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVT 442
Query: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588
+ E VAML+++ +L A Q P + E D
Sbjct: 443 GRTQEELVAMLRSTKQGETASLVI--------ARQEGHFLPREL-KGEPDCCA------- 486
Query: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE-ENHTNQPFFIKTIVLGTPAYYDGRLKC 647
L L ++ +I L S G S+ G E T+ FIK+I+ G A+ DGRL+
Sbjct: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
Query: 648 GDMIVAVNGLSTVGMSHSALVPMLK 672
D ++AVNG S +G S+ + L+
Sbjct: 547 NDQLIAVNGESLLGKSNHEAMETLR 571
Score = 70.9 bits (172), Expect = 4e-12
Identities = 58/211 (27%), Positives = 96/211 (45%), Gaps = 25/211 (11%)
Query: 339 QVALHKRDSGEQLGIKLVRRTDE---PG-VFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394
++ + + E LG +V R PG +F+ ++L G A +DGRL S DR+L +NG D
Sbjct: 381 KIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRD 440
Query: 395 LKYGTPELAAQIIQAS--GERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452
+ T E +++++ GE +L IAR Q G H P P
Sbjct: 441 VTGRTQEELVAMLRSTKQGETASLVIAR----QEG--------------HFLPRELKGEP 482
Query: 453 SSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG-ELPIFVTSVPPHGCLARDG 511
+ I + LG+++ G + ++G +L IF+ S+ G +DG
Sbjct: 483 DCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
Query: 512 RIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542
R++ D L+ +NG L S+ EA+ L+ S
Sbjct: 543 RLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573
Score = 56.6 bits (135), Expect = 7e-08
Identities = 46/151 (30%), Positives = 78/151 (51%), Gaps = 17/151 (11%)
Query: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVL--SQPCNTLHLTVLRE 317
I ++ + G +DGRL +GD+IL+VN +++ + A+L ++ T L + R+
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 318 ------RRFGNRAHNHSDSNSPREEI-FQVALHKRDSGEQ-LGIKLV----RRTD-EPGV 364
R + S E++ F++ L+ DSG LG+ L R T + G+
Sbjct: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLN--DSGSAGLGVSLKGNKSRETGTDLGI 527
Query: 365 FILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395
FI ++ GG A +DGRL ND+++A+NG L
Sbjct: 528 FIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
Score = 55.5 bits (132), Expect = 2e-07
Identities = 58/253 (22%), Positives = 97/253 (38%), Gaps = 48/253 (18%)
Query: 479 LGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
LG+ V S SG L +F+ + + R+G + ++ IN +DL + + ++A
Sbjct: 213 LGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQD 272
Query: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSEN---------------------- 575
+ + + SP+V L L Q E+ ++ + F N
Sbjct: 273 VFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTAN 332
Query: 576 -------EYDASWS------------------PSWVMWLGLPSTLHSCHDIVLRRSYLGS 610
E DAS S PS +G S ++ + +
Sbjct: 333 LTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG 392
Query: 611 WGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670
GF++V H P F+K I+ A DGRL+ GD I+ VNG G + LV M
Sbjct: 393 LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAM 452
Query: 671 LKEQRNKVTLTVI 683
L+ + T +++
Sbjct: 453 LRSTKQGETASLV 465
Score = 33.9 bits (76), Expect = 0.52
Identities = 25/84 (29%), Positives = 39/84 (46%), Gaps = 4/84 (4%)
Query: 224 LSLPEGEITTIEIHRSNP-YIQLGISIVGGNETPL---INIVIQEVYRDGVIARDGRLLA 279
LSL E T EI ++ LG+S+ G + I I+ + G +DGRL
Sbjct: 487 LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546
Query: 280 GDQILQVNNYNISNVSHNYARAVL 303
DQ++ VN ++ S++ A L
Sbjct: 547 NDQLIAVNGESLLGKSNHEAMETL 570
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 83.6 bits (205), Expect = 6e-16
Identities = 65/204 (31%), Positives = 96/204 (47%), Gaps = 27/204 (13%)
Query: 228 EGEITTIEIHRSNPYIQLGISIVGGNETPLIN----IVIQEVYRDGVIARDGRLLAGDQI 283
E E I + R N LG SI GG + P I I I ++ G A DGRL D I
Sbjct: 198 EYEFEEITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 255
Query: 284 LQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALH 343
L+VN ++S VSH+ A L + + + L V R R E + ++ L
Sbjct: 256 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-------------LETVVEIKLF 302
Query: 344 KRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKY 397
K G LG + V PG +++ +++GG A +DGRL DR+L +N + L+
Sbjct: 303 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 360
Query: 398 GTPELAAQIIQASGERVNLTIARP 421
T E A I++ + E V L + +P
Sbjct: 361 VTHEEAVAILKNTSEVVYLKVGKP 384
Score = 69.7 bits (169), Expect = 9e-12
Identities = 58/211 (27%), Positives = 93/211 (44%), Gaps = 43/211 (20%)
Query: 476 HESLGMTVAGGRGSKS-GELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + G+ P IF+T + P G A DGR++ D +L +N +D++ +SHS
Sbjct: 210 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 269
Query: 534 EAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPS 593
+AV LK + + + ++ +P
Sbjct: 270 KAVEALKEAGSIVRLYVR--------------RRRP------------------------ 291
Query: 594 TLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMI 651
L + +I L + G GFSI GG H + ++ I+ G A DGRL+ GD +
Sbjct: 292 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350
Query: 652 VAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
+ VN S ++H V +LK V L V
Sbjct: 351 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/125 (28%), Positives = 62/125 (49%), Gaps = 12/125 (9%)
Query: 302 VLSQPCNTLHLTVLRERRFGNRAHNHSDSNSP----------REEIFQVALHKRDSGEQL 351
+LS P + HL +L + + + + + + P E +V LHK +G L
Sbjct: 479 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG--L 536
Query: 352 GIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASG 411
G +V D G+F+ +L GG A G L D++L++NG DL+ + E AA ++ +G
Sbjct: 537 GFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAG 596
Query: 412 ERVNL 416
+ V +
Sbjct: 597 QTVTI 601
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 3/85 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H FI I+ G A DGRL+ D I+ VN +
Sbjct: 203 EITLERGNSGL-GFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 261
Query: 658 STVGMSHSALVPMLKEQRNKVTLTV 682
+SHS V LKE + V L V
Sbjct: 262 DVSEVSHSKAVEALKEAGSIVRLYV 286
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 5/80 (6%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
+VL + G GF+IVGG + + F+ I+ G PA G L+ GD I++VNG+
Sbjct: 527 VVLHKGSTGL-GFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
Query: 661 GMSHSALVPMLKEQRNKVTL 680
G SH LK VT+
Sbjct: 582 GASHEQAAAALKGAGQTVTI 601
Score = 44.7 bits (104), Expect = 3e-04
Identities = 47/184 (25%), Positives = 76/184 (41%), Gaps = 22/184 (11%)
Query: 165 PTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPL 224
P D + LS G +P + + ST + +P + T Q+ +
Sbjct: 471 PVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSM------------TLQRAV 518
Query: 225 SLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQIL 284
SL EGE + +H+ + LG +IVGG + I + + G G L GDQIL
Sbjct: 519 SL-EGEPRKVVLHKGST--GLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQIL 573
Query: 285 QVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHK 344
VN ++ SH A A L T +T++ + + + A + + RE++ H
Sbjct: 574 SVNGIDLRGASHEQAAAALKGAGQT--VTIIAQYQPEDYARFEAKIHDLREQMMN---HS 628
Query: 345 RDSG 348
SG
Sbjct: 629 MSSG 632
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 83.6 bits (205), Expect = 6e-16
Identities = 65/204 (31%), Positives = 96/204 (47%), Gaps = 27/204 (13%)
Query: 228 EGEITTIEIHRSNPYIQLGISIVGGNETPLIN----IVIQEVYRDGVIARDGRLLAGDQI 283
E E I + R N LG SI GG + P I I I ++ G A DGRL D I
Sbjct: 93 EYEFEEITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 150
Query: 284 LQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALH 343
L+VN ++S VSH+ A L + + + L V R R E + ++ L
Sbjct: 151 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-------------LETVVEIKLF 197
Query: 344 KRDSGEQLGIKL---VRRTDEPG---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKY 397
K G LG + V PG +++ +++GG A +DGRL DR+L +N + L+
Sbjct: 198 KGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 255
Query: 398 GTPELAAQIIQASGERVNLTIARP 421
T E A I++ + E V L + +P
Sbjct: 256 VTHEEAVAILKNTSEVVYLKVGKP 279
Score = 69.7 bits (169), Expect = 9e-12
Identities = 58/211 (27%), Positives = 93/211 (44%), Gaps = 43/211 (20%)
Query: 476 HESLGMTVAGGRGSKS-GELP-IFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHS 533
+ LG ++AGG + G+ P IF+T + P G A DGR++ D +L +N +D++ +SHS
Sbjct: 105 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 164
Query: 534 EAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPS 593
+AV LK + + + ++ +P
Sbjct: 165 KAVEALKEAGSIVRLYVR--------------RRRP------------------------ 186
Query: 594 TLHSCHDIVLRRSYLGSWGFSIVGGYEENHT--NQPFFIKTIVLGTPAYYDGRLKCGDMI 651
L + +I L + G GFSI GG H + ++ I+ G A DGRL+ GD +
Sbjct: 187 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245
Query: 652 VAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
+ VN S ++H V +LK V L V
Sbjct: 246 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/125 (28%), Positives = 62/125 (49%), Gaps = 12/125 (9%)
Query: 302 VLSQPCNTLHLTVLRERRFGNRAHNHSDSNSP----------REEIFQVALHKRDSGEQL 351
+LS P + HL +L + + + + + + P E +V LHK +G L
Sbjct: 374 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG--L 431
Query: 352 GIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASG 411
G +V D G+F+ +L GG A G L D++L++NG DL+ + E AA ++ +G
Sbjct: 432 GFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAG 491
Query: 412 ERVNL 416
+ V +
Sbjct: 492 QTVTI 496
Score = 47.8 bits (112), Expect = 3e-05
Identities = 34/85 (40%), Positives = 42/85 (49%), Gaps = 3/85 (3%)
Query: 600 DIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+I L R G GFSI GG + H FI I+ G A DGRL+ D I+ VN +
Sbjct: 98 EITLERGNSGL-GFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 156
Query: 658 STVGMSHSALVPMLKEQRNKVTLTV 682
+SHS V LKE + V L V
Sbjct: 157 DVSEVSHSKAVEALKEAGSIVRLYV 181
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/80 (36%), Positives = 41/80 (51%), Gaps = 5/80 (6%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
+VL + G GF+IVGG + + F+ I+ G PA G L+ GD I++VNG+
Sbjct: 422 VVLHKGSTGL-GFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 476
Query: 661 GMSHSALVPMLKEQRNKVTL 680
G SH LK VT+
Sbjct: 477 GASHEQAAAALKGAGQTVTI 496
Score = 44.7 bits (104), Expect = 3e-04
Identities = 47/184 (25%), Positives = 76/184 (41%), Gaps = 22/184 (11%)
Query: 165 PTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPL 224
P D + LS G +P + + ST + +P + T Q+ +
Sbjct: 366 PVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSM------------TLQRAV 413
Query: 225 SLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQIL 284
SL EGE + +H+ + LG +IVGG + I + + G G L GDQIL
Sbjct: 414 SL-EGEPRKVVLHKGST--GLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQIL 468
Query: 285 QVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHK 344
VN ++ SH A A L T +T++ + + + A + + RE++ H
Sbjct: 469 SVNGIDLRGASHEQAAAALKGAGQT--VTIIAQYQPEDYARFEAKIHDLREQMMN---HS 523
Query: 345 RDSG 348
SG
Sbjct: 524 MSSG 527
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 83.2 bits (204), Expect = 7e-16
Identities = 81/332 (24%), Positives = 152/332 (45%), Gaps = 23/332 (6%)
Query: 229 GEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNN 288
G I +E+ + + + + +S G++ IV+ +V G RDGRL GD++L +N
Sbjct: 330 GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389
Query: 289 YNISNVSHNYARAVLSQPCNTLHLTV------------LRERRFGNRAHNHSDSNSPREE 336
+ + +SH A A+L + L V L + + + D +S +
Sbjct: 390 HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDN 449
Query: 337 IFQVALHKRDSGEQLGI-KLVRRTDEP-GVFILDLLEGGLAAQDGRLSSNDRVLAINGHD 394
Q A + D G + + + TDEP V + +G L + + ++G
Sbjct: 450 EDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV 509
Query: 395 LKYGTPELAAQIIQASGE-RVN-LTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRP 452
+ + E +++ +G+ R+ L ++R G+ +++ + + SS+SQ + +R
Sbjct: 510 HRLESVEEYNELMVRNGDPRIRMLEVSRDGRK---HSLPQLLDSSSASQEYHIVKKSTRS 566
Query: 453 SSHKDLTQCVTCQEKHIT----VKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLA 508
S + + + KE + LG ++AGGR G++ IFV ++ P+G A
Sbjct: 567 LSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAA 626
Query: 509 RDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
DGR+K GD +L++NGI + L+ EA+ K
Sbjct: 627 EDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK 658
Score = 73.6 bits (179), Expect = 6e-13
Identities = 82/344 (23%), Positives = 139/344 (40%), Gaps = 36/344 (10%)
Query: 260 IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERR 319
I + E+ ++ + G++ D+IL +N + V + A + Q N + ++ RR
Sbjct: 119 IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRR 178
Query: 320 FGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPG-----VFILDLLEGGL 374
F ++AH+ + NS + GE ++L RT + G ++
Sbjct: 179 FKHKAHSTYNGNSSNSS---------EPGETPTLELGDRTAKKGKRTRKFGVISRPPANK 229
Query: 375 AAQDGRLSSNDRVLAINGHDLKYGT-PELAAQIIQASGERVNLTIARPGKPQPGNTIREA 433
A ++ + S+ V + +L+ G PEL +G L + E
Sbjct: 230 APEESKGSAGCEVSSDPSTELENGPDPELG------NGHVFQLENGPDSLKEVAGPHLER 283
Query: 434 GNHSSSSQHHTPPPYYSRPSSHK------------DLTQCVTCQEKHITVKKE---PHES 478
++H P +S+ + C+ +E K E +
Sbjct: 284 SEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDG 343
Query: 479 LGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAM 538
LG+ V+GGRGSK I VT V G RDGR+ GD LL ING L LSH EAVA+
Sbjct: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
Query: 539 LKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWS 582
L+++ + + + E + ++ P S E +SW+
Sbjct: 404 LRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWT 447
Score = 62.0 bits (149), Expect = 2e-09
Identities = 51/196 (26%), Positives = 91/196 (46%), Gaps = 5/196 (2%)
Query: 469 ITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLT 528
I + ++ LG +VAGG + I V V G +++G + RGD LL++NG L
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDVEPKS--ITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
Query: 529 NLSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMW 588
L+H + +L A AL ++ + +++ +A ++P T + + +
Sbjct: 2681 GLAHGNVLKVLH-QAQLHKDALVVIK-KGMDQPRPSARQEPPTANGKGLLSRKTIPLEPG 2738
Query: 589 LGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCG 648
+G +H + + ++ G G S+ GG + P IK + G A G ++ G
Sbjct: 2739 IGRSVAVHDALCVEVLKTSAGL-GLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
Query: 649 DMIVAVNGLSTVGMSH 664
D I+A+NG VG+ H
Sbjct: 2798 DEILAINGKPLVGLMH 2813
Score = 60.1 bits (144), Expect = 7e-09
Identities = 94/387 (24%), Positives = 155/387 (40%), Gaps = 58/387 (14%)
Query: 317 ERRF--GNRAHNHSDSNSPREE---IFQVALHKRDSGEQLGIKLV----RRTDEPGVFIL 367
+RRF G + S REE I+++ L K G LGI++ + + +
Sbjct: 307 KRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDG--LGIQVSGGRGSKRSPHAIVVT 364
Query: 368 DLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGK---- 423
+ EGG A +DGRLS D +L INGH L + E A I++++ V L +A
Sbjct: 365 QVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAED 424
Query: 424 ---------PQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKE 474
P +++ + + + + SS T + + + +E
Sbjct: 425 LLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEE 484
Query: 475 PHESLGMTVAGGRGSK-----SGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
+L G K SG + + SV + L ++ GD + + +
Sbjct: 485 SKGNLESPKQGSNKIKLKSRLSGGVHR-LESVEEYNELM----VRNGDPRIRMLEVSRDG 539
Query: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWL 589
HS +L +S+AS E IV+++T++ S + ++ W L
Sbjct: 540 RKHS-LPQLLDSSSASQ-------EYHIVKKSTRS-------LSTTQVESPWR------L 578
Query: 590 GLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGD 649
PS + I L + GFSI GG + F+KTI A DGRLK GD
Sbjct: 579 IRPSVISI---IGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGD 635
Query: 650 MIVAVNGLSTVGMSHSALVPMLKEQRN 676
I+ VNG+ G++ + K+ R+
Sbjct: 636 EILDVNGIPIKGLTFQEAIHTFKQIRS 662
Score = 57.8 bits (138), Expect = 3e-08
Identities = 53/222 (23%), Positives = 97/222 (43%), Gaps = 14/222 (6%)
Query: 335 EEIFQVALHKRDSGEQLGIKLVRRTD-EP-GVFILDLLEGGLAAQDGRLSSNDRVLAING 392
E++ + L++++ G LG + TD EP + + + G A+Q+G ++ D +L++NG
Sbjct: 2618 EDVCFIVLNRKE-GSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676
Query: 393 HDLK-YGTPELAAQIIQASGERVNLTIARPGKPQPGNTIRE---AGNHSSSSQHHTPPPY 448
L + + QA + L + + G QP + R+ N T P
Sbjct: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIP-- 2734
Query: 449 YSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLA 508
+ + V + + LG+++ GG+ S +G+ P+ + V G
Sbjct: 2735 -----LEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAE 2789
Query: 509 RDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVAL 550
+ G I+ GD +L ING L L H +A ++K+ P L
Sbjct: 2790 QAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLL 2831
Score = 54.7 bits (130), Expect = 3e-07
Identities = 81/364 (22%), Positives = 132/364 (36%), Gaps = 64/364 (17%)
Query: 245 LGISIVGGNET--PLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAV 302
LG SI GG + + I ++ ++ +G A DGRL GD+IL VN I ++ A
Sbjct: 597 LGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHT 656
Query: 303 LSQ--------------------PCNT-LHLTVLRERRF---GNRAHNHSDSNS------ 332
Q PC+T H++ F G + SD S
Sbjct: 657 FKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGR 716
Query: 333 ----PREEIFQVALHKRDSGEQLGIK---LVRRTDEPGVFILDLLEGGLAAQDGRLSSND 385
P++ I ++ LGI L PG++I L G +A + LS D
Sbjct: 717 KTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGD 776
Query: 386 RVLAINGHDLKYGT-PELAAQIIQASGERVNLTIARPGKPQPG----------NTIREAG 434
++L +N ++++ ++ A + + V L I R P+ +T +E+
Sbjct: 777 QILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESK 836
Query: 435 NHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG-------GR 487
+SS TP PS K + + P VAG G
Sbjct: 837 EANSSPGLGTP---LKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGS 893
Query: 488 GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPA 547
G + E S+PP ++ R + L+ + + L H + +AS
Sbjct: 894 GCSTSE----EGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVARQASLPGSP 949
Query: 548 VALK 551
AL+
Sbjct: 950 QALR 953
Score = 53.1 bits (126), Expect = 8e-07
Identities = 94/473 (19%), Positives = 171/473 (36%), Gaps = 51/473 (10%)
Query: 192 LTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVG 251
LTS SL P L + + S+ D Q E E T+ + R+ P + G
Sbjct: 428 LTSKSL------PDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCG 481
Query: 252 GNETP--------------LINIVIQEVYRDGVIARDGRLLA--GDQILQVNNYNISNVS 295
E+ L + + V+R + L+ GD +++ +
Sbjct: 482 AEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRK 541
Query: 296 HNYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKL 355
H+ + + S + + V + R + S R + + ++ G+ LG +
Sbjct: 542 HSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSI 601
Query: 356 VRRTD----EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASG 411
D + G+F+ + G AA+DGRL D +L +NG +K T + A +
Sbjct: 602 AGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIR 661
Query: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEK---- 467
+ + R P T H S S + D + K
Sbjct: 662 SGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGP 721
Query: 468 ------HITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLN 521
+T+ KEP LG+ A ++ I++ S+ P + + RGD +L
Sbjct: 722 KDRIVMEVTLNKEPRVGLGIG-ACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780
Query: 522 INGIDLTNLSHSEAVAMLKASAASPA-VALKALEVQIVEEATQNAEEQPSTFSENEYDAS 580
+N +++ + + S+ A+L P + + V E + ST+ E++ +A+
Sbjct: 781 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESK-EAN 839
Query: 581 WSPSWVMWLGLPSTLHSCHDIVLRRSYLGSW----------GFSIVGGYEENH 623
SP L PS D ++ S L + F + G +E+H
Sbjct: 840 SSPGLGTPLKSPSLAKK--DSLISESELSQYFAHDVPGPLSDFMVAGSEDEDH 890
Score = 45.8 bits (107), Expect = 1e-04
Identities = 48/180 (26%), Positives = 75/180 (41%), Gaps = 33/180 (18%)
Query: 245 LGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLS 304
LG S+ GG + +I + V+ G +++G + GD +L VN +++ ++H VL
Sbjct: 2633 LGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLH 2692
Query: 305 QPCNTLHLTVLRERRFGNRAHNHSDSNSP----------REEI-------FQVALH---- 343
Q LH L + G S P R+ I VA+H
Sbjct: 2693 QA--QLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHDALC 2750
Query: 344 ----KRDSGEQLGIKL----VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDL 395
K +G LG+ L T + + I + +GG A Q G + + D +LAING L
Sbjct: 2751 VEVLKTSAG--LGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
Score = 43.1 bits (100), Expect = 9e-04
Identities = 22/71 (30%), Positives = 33/71 (46%)
Query: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
G + GG + + + G A+ DGRL GD ++ +NG VG+SH V +L
Sbjct: 345 GIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAIL 404
Query: 672 KEQRNKVTLTV 682
+ V L V
Sbjct: 405 RSATGMVQLVV 415
Score = 37.7 bits (86), Expect = 0.036
Identities = 25/84 (29%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 601 IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV 660
IVL R GFS+ GG + + + + A +G + GD +++VNG S
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDVEPKS--ITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
Query: 661 GMSHSALVPMLKE-QRNKVTLTVI 683
G++H ++ +L + Q +K L VI
Sbjct: 2681 GLAHGNVLKVLHQAQLHKDALVVI 2704
Score = 34.3 bits (77), Expect = 0.40
Identities = 23/77 (29%), Positives = 41/77 (53%), Gaps = 3/77 (3%)
Query: 245 LGISIVGGNETPLIN--IVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAV 302
LG+S+ GG + + +VI+ VY+ G + G + AGD+IL +N + + H A +
Sbjct: 2760 LGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNI 2819
Query: 303 L-SQPCNTLHLTVLRER 318
+ S P + L + + R
Sbjct: 2820 MKSVPEGPVQLLIRKHR 2836
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 81.3 bits (199), Expect = 3e-15
Identities = 91/386 (23%), Positives = 152/386 (39%), Gaps = 86/386 (22%)
Query: 381 LSSNDRVLAINGHDLKYGTPELAAQIIQA--SGERVNLTIARPGKPQPGNTIR----EAG 434
L D ++ +N +++ T ++ G V L + R G P P + + E
Sbjct: 680 LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK 739
Query: 435 NHSSSSQH--------HTPPPYYS------------------------RPSSHKDLTQCV 462
+ +SSQH HT P +S +P K Q
Sbjct: 740 DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR 799
Query: 463 TCQEKHITVKKEP-------HESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKR 515
+ E + +E G + GG ++ GE PI++ + P G DGR++
Sbjct: 800 SMYENRLPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PIYIGHIVPLGAADTDGRLRS 856
Query: 516 GDVLLNINGIDLTNLSHSEAVAMLKASAASPAV----------ALKALEVQIVEEATQN- 564
GD L+ ++G + SH V +++ +A V A+ E ++ A+ +
Sbjct: 857 GDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHH 916
Query: 565 AEEQPSTFSENEYDASWSPSWVMWL------------------GLPSTLHSCHDIVLRRS 606
+ QP++ +E + S + + + G+ ST+ +D+ +RR
Sbjct: 917 SSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRG 976
Query: 607 YLGSWGFSIVGGYEENHTN---------QPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
+GF IV P I I+ G+PA G+LK GD I+AVNG
Sbjct: 977 ENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGC 1036
Query: 658 STVGMSHSALVPMLKEQRNKVTLTVI 683
S SHS +V ++KE N VTL +I
Sbjct: 1037 SITNKSHSDIVNLIKEAGNTVTLRII 1062
Score = 77.0 bits (188), Expect = 5e-14
Identities = 84/382 (21%), Positives = 154/382 (40%), Gaps = 56/382 (14%)
Query: 360 DEPG--VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGER--VN 415
+EPG ++I ++ G A DGRL S D ++ ++G + + +L Q++Q + ++ VN
Sbjct: 831 NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890
Query: 416 LTIARP---GKPQPGNTIRE-AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC------- 464
LT+ R P+ N + A +H SS+Q + P ++ V+
Sbjct: 891 LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950
Query: 465 ----------------QEKHITVKKEPHESLGMTVAGGR---------GSKSGELPIFVT 499
Q + +++ +E G + G+ +P +
Sbjct: 951 IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010
Query: 500 SVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASA------------ASPA 547
+ R G++K GD +L +NG +TN SHS+ V ++K + +S A
Sbjct: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNA 1070
Query: 548 VALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSY 607
L E T +Q + + N + + + + L R
Sbjct: 1071 TLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1130
Query: 608 LGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSAL 667
G +GFS+ GG E N ++ + PA G+++ GD I+ +NG +T M HS
Sbjct: 1131 KG-FGFSLRGGREYN---MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRA 1186
Query: 668 VPMLKEQRNKVTLTVICWPGSL 689
+ ++K +V L + GS+
Sbjct: 1187 IELIKNGGRRVRLFLKRGDGSV 1208
Score = 59.3 bits (142), Expect = 1e-08
Identities = 112/493 (22%), Positives = 184/493 (37%), Gaps = 138/493 (27%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G ++VGG+E P + I+ + DG A DG++ GD I+ VN+ + + H +A+ V
Sbjct: 483 GFTVVGGDE-PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV--LGHTHAQVV--- 536
Query: 306 PCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF 365
+IFQ G + ++L R P F
Sbjct: 537 ------------------------------KIFQ----SIPIGASVDLELCRGYPLP--F 560
Query: 366 ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
D L L + +NG + Y +P A +G+ + ARP P
Sbjct: 561 DPDDPNTSLVTSVAILDKEP--IIVNGQE-TYDSP---ASHSSKTGKVNGMKDARPSSP- 613
Query: 426 PGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG 485
+ +S+S H P S SS + +T + + K P G T+A
Sbjct: 614 --------ADVASNSSHGYPNDTVSLASSIATQPELIT-----VHIVKGP-MGFGFTIAD 659
Query: 486 GRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML------ 539
G + V S G +K GD+++ +N ++ L+H++ V ML
Sbjct: 660 SPGGGGQRVKQIVDSPRCRG-------LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKG 712
Query: 540 -----------------------------------------KASAASPAVALKAL----- 553
ASP+ + + L
Sbjct: 713 SEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPP 772
Query: 554 -EVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLG-LPSTLHSCHDIVLRRSYLGSW 611
E Q ++ + +++P F W+ S M+ LP + DI L R G +
Sbjct: 773 AEAQAPDQTDSSGQKKPDPFK------IWAQSRSMYENRLPD--YQEQDIFLWRKETG-F 823
Query: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
GF I+GG N +P +I IV A DGRL+ GD ++ V+G +G SH +V ++
Sbjct: 824 GFRILGG---NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLM 880
Query: 672 KE--QRNKVTLTV 682
++ ++ V LTV
Sbjct: 881 QQAAKQGHVNLTV 893
Score = 58.9 bits (141), Expect = 2e-08
Identities = 50/214 (23%), Positives = 94/214 (43%), Gaps = 14/214 (6%)
Query: 369 LLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGN 428
++EG A + G+L DR+LA+NG + + +I+ +G V L I +
Sbjct: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1071
Query: 429 TIREAGNHSSSSQHHTPPPYYSRPSSH----KDLTQC------VTCQEKHITVKKEPH-E 477
+ A ++ + HTP ++ + + K +Q T ++ TV+ E +
Sbjct: 1072 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1131
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
G ++ GGR + ++V + G R G+++ GD +L ING N+ HS A+
Sbjct: 1132 GFGFSLRGGR---EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1188
Query: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPST 571
++K + LK + + E + P+T
Sbjct: 1189 LIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPAT 1222
Score = 49.3 bits (116), Expect = 1e-05
Identities = 28/70 (40%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 603 LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGM 662
LR+S G +GF++VGG E + Q IK++VL PA DG+++ GD+IV+VN +G
Sbjct: 475 LRKSSRG-FGFTVVGGDEPDEFLQ---IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 663 SHSALVPMLK 672
+H+ +V + +
Sbjct: 531 THAQVVKIFQ 540
Score = 47.8 bits (112), Expect = 3e-05
Identities = 49/211 (23%), Positives = 78/211 (36%), Gaps = 48/211 (22%)
Query: 273 RDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVL------------RERRF 320
R G+L GD+IL VN +I+N SH+ ++ + NT+ L ++ +
Sbjct: 1020 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI 1079
Query: 321 GNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------------------ 362
H+ S +E K++S Q K + T E
Sbjct: 1080 ATITTTHTPSQQGTQETRNTTKPKQES--QFEFKAPQATQEQDFYTVELERGAKGFGFSL 1137
Query: 363 --------GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERV 414
+++L L E G A + G++ D +L ING K A ++I+ G RV
Sbjct: 1138 RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRV 1197
Query: 415 NLTIARPGKPQPGNTIREAGNHSSSSQHHTP 445
L + R P + SS H P
Sbjct: 1198 RLFLKRGDGSVP--------EYDPSSDRHGP 1220
Score = 38.5 bits (88), Expect = 0.021
Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 223 PLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQ 282
P + E + T+E+ R G S+ GG E + ++ + + DG R G++ GD+
Sbjct: 1113 PQATQEQDFYTVELERGAK--GFGFSLRGGREYNM-DLYVLRLAEDGPAERCGKMRIGDE 1169
Query: 283 ILQVNNYNISNVSHNYA 299
IL++N N+ H+ A
Sbjct: 1170 ILEINGETTKNMKHSRA 1186
Score = 37.7 bits (86), Expect = 0.036
Identities = 31/99 (31%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G I+GGNE P I I + G DGRL +GD+++ V+ + SH ++ Q
Sbjct: 824 GFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882
Query: 306 PCNTLH--LTVLR---------ERRFGNRAHNHSDSNSP 333
H LTV R E + A +H SN P
Sbjct: 883 AAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 921
Score = 35.4 bits (80), Expect = 0.18
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 463 TCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDG-----RIKRGD 517
T + TVK+ P LG+TV G G++ GE P +V +V G R+ G+
Sbjct: 12 TSRVHECTVKRGPQGELGVTVLG--GAEHGEFP-YVGAVAAVEAAGLPGGGEGPRLGEGE 68
Query: 518 VLLNINGIDLTNLSHSEAVAMLKASAASPAVALKAL 553
+LL + G+ ++ L + + ++ + AV KA+
Sbjct: 69 LLLEVQGVRVSGLPRYDVLGVI--DSCKEAVTFKAV 102
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/82 (24%), Positives = 42/82 (51%), Gaps = 3/82 (3%)
Query: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
T ++ G TV GG + E + + S+ G A DG+++ GDV++++N +
Sbjct: 473 TKLRKSSRGFGFTVVGG--DEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 530 LSHSEAVAMLKASAASPAVALK 551
+H++ V + ++ +V L+
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLE 551
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 81.3 bits (199), Expect = 3e-15
Identities = 78/278 (28%), Positives = 125/278 (44%), Gaps = 26/278 (9%)
Query: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPP--YYSRPSSHKDLTQCVTCQEKHI 469
E +N I +P P P + IR S+ + Y +P + KDL + QE
Sbjct: 678 EAINEPIPQP-MPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES-- 734
Query: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
G V GG G I++ ++ P G +DGR++ D L+ I+GI +
Sbjct: 735 --------GFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783
Query: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPS-WVMW 588
SH + + ++ +A + V L V E+QP S + ++ + S +
Sbjct: 784 KSHKQVLDLMTTAARNGHVLLT------VRRKIFYGEKQPEDDSSQAFISTQNGSPRLNR 837
Query: 589 LGLPS--TLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQ-PFFIKTIVLGTPAYYDGRL 645
+P+ +D+VL+R +GF I+ + P I ++ G+PA G+L
Sbjct: 838 AEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKL 897
Query: 646 KCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
K GD I AVNG S V +SH +V ++K+ VTLTVI
Sbjct: 898 KVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
Score = 75.1 bits (183), Expect = 2e-13
Identities = 89/399 (22%), Positives = 158/399 (39%), Gaps = 64/399 (16%)
Query: 329 DSNSPREEIFQVALHKRDSGEQLGIKLVRRTD-EPGVFILDLLEGGLAAQDGRLSSNDRV 387
+ P + V L K++SG G +++ + ++I ++ G A +DGRL + D +
Sbjct: 716 EDKPPNTKDLDVFLRKQESG--FGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADEL 773
Query: 388 LAINGHDLKYGTPELAAQIIQASGER--VNLTIARP---GKPQPGNTIREA---GNHSSS 439
+ I+G +K + + ++ + V LT+ R G+ QP + +A + S
Sbjct: 774 MCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSP 833
Query: 440 SQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS-GELPIFV 498
+ P P D + ++++ +E G + + G +P +
Sbjct: 834 RLNRAEVPARPAPQEPYD-----------VVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882
Query: 499 TSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIV 558
V R G++K GD + +NG + LSH V ++K + + + + A E
Sbjct: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG 942
Query: 559 EEATQNAEEQPSTFSEN-----------------------EYDASWSPSWV--MWLGLPS 593
+ N+ Q + S+ SW L P
Sbjct: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPD 1002
Query: 594 TL--------HS----CHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641
T H+ C+ + L R G +GFS+ GG E N FI + PA
Sbjct: 1003 TAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGGKEYN---MGLFILRLAEDGPAIK 1058
Query: 642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
DGR+ GD IV +NG T G++H+ + +++ NKV L
Sbjct: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLL 1097
Score = 72.8 bits (177), Expect = 1e-12
Identities = 84/368 (22%), Positives = 153/368 (41%), Gaps = 66/368 (17%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G ++GG + P +I I + G +DGRL A D+++ ++ + SH +++
Sbjct: 737 GFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT 795
Query: 306 PCNTLH--LTVLRERRFGNR--------AHNHSDSNSPR------------EEIFQVALH 343
H LTV R+ +G + A + + SPR +E + V L
Sbjct: 796 AARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQ 855
Query: 344 KRDSGEQLGIKLVRRTDEPGVFILD-----LLEGGLAAQDGRLSSNDRVLAINGHDLKYG 398
++++ E G ++ ++P ++ ++EG A + G+L D + A+NG +
Sbjct: 856 RKEN-EGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVEL 914
Query: 399 TPELAAQIIQASGERVNLTI----ARPGKPQPGNTIRE--AGNH---SSSSQHHTP---- 445
+ + Q+I+ +G V LT+ G P N+ R+ A H S +H P
Sbjct: 915 SHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
Query: 446 -----------PPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG---MTVAGG----- 486
Y S HK L Q T V +++LG + + G
Sbjct: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVIS--VVGSRHNQNLGCYPVELERGPRGFG 1032
Query: 487 ---RGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASA 543
RG K + +F+ + G +DGRI GD ++ ING ++H+ A+ +++A
Sbjct: 1033 FSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGG 1092
Query: 544 ASPAVALK 551
+ L+
Sbjct: 1093 NKVLLLLR 1100
Score = 49.3 bits (116), Expect = 1e-05
Identities = 41/116 (35%), Positives = 59/116 (50%), Gaps = 13/116 (11%)
Query: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
G+FIL L E G A +DGR+ D+++ ING + T A ++IQA G +V L + RPG
Sbjct: 1044 GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV-LLLLRPG 1102
Query: 423 KPQ-PGNTIREAGNHSSSS---QHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKE 474
P + + N SSS+ +P P PSSH +E H+ V +E
Sbjct: 1103 TGLIPDHGDWDINNPSSSNVIYDEQSPLP----PSSH----FASIFEESHVPVIEE 1150
Score = 47.4 bits (111), Expect = 5e-05
Identities = 97/429 (22%), Positives = 171/429 (39%), Gaps = 85/429 (19%)
Query: 323 RAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF--ILDLLEGGLAAQDGR 380
++H D + + + + +L K G G ++ D P F + ++L+ G AAQDG+
Sbjct: 394 KSHFTRDPSQLKGVLVRASLKKSTMG--FGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGK 450
Query: 381 LSSNDRVLAINGHDLKYGTPELAAQIIQ--ASGERVNLTIARPGKPQPGNTIREAGNHSS 438
++ D ++ ING+ + T Q+ Q + VNLT+ R G P P ++ + +
Sbjct: 451 IAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR-GYPLPDDSEDPVVDIVA 509
Query: 439 SSQHHTPPPYYSRPSSHKDLTQCVTCQE-KHITVKKEPHESLGMTVAG------------ 485
++ P + S K T C+ Q+ K + E + G T+ G
Sbjct: 510 AT------PVINGQSLTKGET-CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQ 562
Query: 486 -----GRGSKSGELPIFVTSVPPHGC--------------LARDGR----IKRGDVLLNI 522
GS EL P G + D + +++GD++ I
Sbjct: 563 RVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEI 622
Query: 523 NGIDLTNLSHSEAVAMLKASAASPAVALKALE------VQIVEEATQNAEEQPSTFSENE 576
++ NL+H + V +LK V L L + + T E S + NE
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
Query: 577 ---YDASWSPSWVMWLGLP-----------STLHSCH-------DIVLRRSYLGSWGFSI 615
+ PS ++ G P TL+ D+ LR+ G +GF +
Sbjct: 683 PIPQPMPFPPS-IIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESG-FGFRV 740
Query: 616 VGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML--KE 673
+GG + +Q +I I+ A DGRL+ D ++ ++G+ G SH ++ ++
Sbjct: 741 LGG---DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
Query: 674 QRNKVTLTV 682
+ V LTV
Sbjct: 798 RNGHVLLTV 806
Score = 37.7 bits (86), Expect = 0.036
Identities = 26/88 (29%), Positives = 42/88 (47%), Gaps = 2/88 (2%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G S+ GG E + + I + DG +DGR+ GDQI+++N ++H A ++
Sbjct: 1032 GFSLRGGKEYNM-GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQA 1090
Query: 306 PCNTLHLTVLRERRFGNRAHNHSDSNSP 333
N + L +LR H D N+P
Sbjct: 1091 GGNKV-LLLLRPGTGLIPDHGDWDINNP 1117
Score = 35.4 bits (80), Expect = 0.18
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 203 EPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVI 262
E G P E+S T+ P L +G + + +S + G +I+GG+ P + +
Sbjct: 384 EIGSSKPDMEKS---HFTRDPSQL-KGVLVRASLKKST--MGFGFTIIGGDR-PDEFLQV 436
Query: 263 QEVYRDGVIARDGRLLAGDQILQVNNYNISNVSH 296
+ V +DG A+DG++ GD I+ +N + +H
Sbjct: 437 KNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
Score = 35.4 bits (80), Expect = 0.18
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Query: 450 SRPSSHKDLTQCVTCQEKHITVK---KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGC 506
S+P K Q K + V+ K+ G T+ GG + E + V +V G
Sbjct: 388 SKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG--DRPDEF-LQVKNVLKDGP 444
Query: 507 LARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
A+DG+I GDV+++ING + +H++ V M +
Sbjct: 445 AAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 81.3 bits (199), Expect = 3e-15
Identities = 78/278 (28%), Positives = 125/278 (44%), Gaps = 26/278 (9%)
Query: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPP--YYSRPSSHKDLTQCVTCQEKHI 469
E +N I +P P P + IR S+ + Y +P + KDL + QE
Sbjct: 678 EAINEPIPQP-MPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES-- 734
Query: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
G V GG G I++ ++ P G +DGR++ D L+ I+GI +
Sbjct: 735 --------GFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKG 783
Query: 530 LSHSEAVAMLKASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPS-WVMW 588
SH + + ++ +A + V L V E+QP S + ++ + S +
Sbjct: 784 KSHKQVLDLMTTAARNGHVLLT------VRRKIFYGEKQPEDDSSQAFISTQNGSPRLNR 837
Query: 589 LGLPS--TLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQ-PFFIKTIVLGTPAYYDGRL 645
+P+ +D+VL+R +GF I+ + P I ++ G+PA G+L
Sbjct: 838 AEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKL 897
Query: 646 KCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
K GD I AVNG S V +SH +V ++K+ VTLTVI
Sbjct: 898 KVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI 935
Score = 75.1 bits (183), Expect = 2e-13
Identities = 89/399 (22%), Positives = 158/399 (39%), Gaps = 64/399 (16%)
Query: 329 DSNSPREEIFQVALHKRDSGEQLGIKLVRRTD-EPGVFILDLLEGGLAAQDGRLSSNDRV 387
+ P + V L K++SG G +++ + ++I ++ G A +DGRL + D +
Sbjct: 716 EDKPPNTKDLDVFLRKQESG--FGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADEL 773
Query: 388 LAINGHDLKYGTPELAAQIIQASGER--VNLTIARP---GKPQPGNTIREA---GNHSSS 439
+ I+G +K + + ++ + V LT+ R G+ QP + +A + S
Sbjct: 774 MCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSP 833
Query: 440 SQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKS-GELPIFV 498
+ P P D + ++++ +E G + + G +P +
Sbjct: 834 RLNRAEVPARPAPQEPYD-----------VVLQRKENEGFGFVILTSKNKPPPGVIPHKI 882
Query: 499 TSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIV 558
V R G++K GD + +NG + LSH V ++K + + + + A E
Sbjct: 883 GRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHG 942
Query: 559 EEATQNAEEQPSTFSEN-----------------------EYDASWSPSWV--MWLGLPS 593
+ N+ Q + S+ SW L P
Sbjct: 943 PPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPD 1002
Query: 594 TL--------HS----CHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYY 641
T H+ C+ + L R G +GFS+ GG E N FI + PA
Sbjct: 1003 TAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGGKEYN---MGLFILRLAEDGPAIK 1058
Query: 642 DGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
DGR+ GD IV +NG T G++H+ + +++ NKV L
Sbjct: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLL 1097
Score = 72.8 bits (177), Expect = 1e-12
Identities = 84/368 (22%), Positives = 153/368 (41%), Gaps = 66/368 (17%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G ++GG + P +I I + G +DGRL A D+++ ++ + SH +++
Sbjct: 737 GFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTT 795
Query: 306 PCNTLH--LTVLRERRFGNR--------AHNHSDSNSPR------------EEIFQVALH 343
H LTV R+ +G + A + + SPR +E + V L
Sbjct: 796 AARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQ 855
Query: 344 KRDSGEQLGIKLVRRTDEPGVFILD-----LLEGGLAAQDGRLSSNDRVLAINGHDLKYG 398
++++ E G ++ ++P ++ ++EG A + G+L D + A+NG +
Sbjct: 856 RKEN-EGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVEL 914
Query: 399 TPELAAQIIQASGERVNLTI----ARPGKPQPGNTIRE--AGNH---SSSSQHHTP---- 445
+ + Q+I+ +G V LT+ G P N+ R+ A H S +H P
Sbjct: 915 SHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
Query: 446 -----------PPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG---MTVAGG----- 486
Y S HK L Q T V +++LG + + G
Sbjct: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVIS--VVGSRHNQNLGCYPVELERGPRGFG 1032
Query: 487 ---RGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASA 543
RG K + +F+ + G +DGRI GD ++ ING ++H+ A+ +++A
Sbjct: 1033 FSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGG 1092
Query: 544 ASPAVALK 551
+ L+
Sbjct: 1093 NKVLLLLR 1100
Score = 47.4 bits (111), Expect = 5e-05
Identities = 97/429 (22%), Positives = 171/429 (39%), Gaps = 85/429 (19%)
Query: 323 RAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF--ILDLLEGGLAAQDGR 380
++H D + + + + +L K G G ++ D P F + ++L+ G AAQDG+
Sbjct: 394 KSHFTRDPSQLKGVLVRASLKKSTMG--FGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGK 450
Query: 381 LSSNDRVLAINGHDLKYGTPELAAQIIQ--ASGERVNLTIARPGKPQPGNTIREAGNHSS 438
++ D ++ ING+ + T Q+ Q + VNLT+ R G P P ++ + +
Sbjct: 451 IAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCR-GYPLPDDSEDPVVDIVA 509
Query: 439 SSQHHTPPPYYSRPSSHKDLTQCVTCQE-KHITVKKEPHESLGMTVAG------------ 485
++ P + S K T C+ Q+ K + E + G T+ G
Sbjct: 510 AT------PVINGQSLTKGET-CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQ 562
Query: 486 -----GRGSKSGELPIFVTSVPPHGC--------------LARDGR----IKRGDVLLNI 522
GS EL P G + D + +++GD++ I
Sbjct: 563 RVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEI 622
Query: 523 NGIDLTNLSHSEAVAMLKASAASPAVALKALE------VQIVEEATQNAEEQPSTFSENE 576
++ NL+H + V +LK V L L + + T E S + NE
Sbjct: 623 YHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINE 682
Query: 577 ---YDASWSPSWVMWLGLP-----------STLHSCH-------DIVLRRSYLGSWGFSI 615
+ PS ++ G P TL+ D+ LR+ G +GF +
Sbjct: 683 PIPQPMPFPPS-IIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESG-FGFRV 740
Query: 616 VGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML--KE 673
+GG + +Q +I I+ A DGRL+ D ++ ++G+ G SH ++ ++
Sbjct: 741 LGG---DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
Query: 674 QRNKVTLTV 682
+ V LTV
Sbjct: 798 RNGHVLLTV 806
Score = 46.6 bits (109), Expect = 8e-05
Identities = 26/60 (43%), Positives = 37/60 (61%), Gaps = 1/60 (1%)
Query: 363 GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPG 422
G+FIL L E G A +DGR+ D+++ ING + T A ++IQA G +V L + RPG
Sbjct: 1044 GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV-LLLLRPG 1102
Score = 35.4 bits (80), Expect = 0.18
Identities = 26/94 (27%), Positives = 47/94 (50%), Gaps = 7/94 (7%)
Query: 203 EPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVI 262
E G P E+S T+ P L +G + + +S + G +I+GG+ P + +
Sbjct: 384 EIGSSKPDMEKS---HFTRDPSQL-KGVLVRASLKKST--MGFGFTIIGGDR-PDEFLQV 436
Query: 263 QEVYRDGVIARDGRLLAGDQILQVNNYNISNVSH 296
+ V +DG A+DG++ GD I+ +N + +H
Sbjct: 437 KNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTH 470
Score = 35.4 bits (80), Expect = 0.18
Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Query: 450 SRPSSHKDLTQCVTCQEKHITVK---KEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGC 506
S+P K Q K + V+ K+ G T+ GG + E + V +V G
Sbjct: 388 SKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGG--DRPDEF-LQVKNVLKDGP 444
Query: 507 LARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK 540
A+DG+I GDV+++ING + +H++ V M +
Sbjct: 445 AAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 79.3 bits (194), Expect = 1e-14
Identities = 64/234 (27%), Positives = 106/234 (45%), Gaps = 39/234 (16%)
Query: 488 GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPA 547
G++ GE PI++ + P G DGR++ GD L+ ++G + SH V +++ +A
Sbjct: 858 GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGH 916
Query: 548 V----------ALKALEVQIVEEATQN-AEEQPSTFSENEYDASWSPSWVMWL------- 589
V A+ E ++ A+ + + QP++ +E + S + + +
Sbjct: 917 VNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST 976
Query: 590 -----------GLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTN---------QPFF 629
G+ ST+ +D+ +RR +GF IV P
Sbjct: 977 SGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHK 1036
Query: 630 IKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
I I+ G+PA G+LK GD I+AVNG S SHS +V ++KE N VTL +I
Sbjct: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1090
Score = 77.4 bits (189), Expect = 4e-14
Identities = 92/426 (21%), Positives = 173/426 (40%), Gaps = 61/426 (14%)
Query: 316 RERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPG--VFILDLLEGG 373
RER + N + P + + L ++++G G +++ +EPG ++I ++ G
Sbjct: 820 REREINST--NFGECPIPDYQEQDIFLWRKETG--FGFRILGG-NEPGEPIYIGHIVPLG 874
Query: 374 LAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGER--VNLTIARP---GKPQPGN 428
A DGRL S D ++ ++G + + +L Q++Q + ++ VNLT+ R P+ N
Sbjct: 875 AADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN 934
Query: 429 TIRE-AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC----------------------- 464
+ A +H SS+Q + P ++ V+
Sbjct: 935 EVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV 994
Query: 465 QEKHITVKKEPHESLGMTVAGGR---------GSKSGELPIFVTSVPPHGCLARDGRIKR 515
Q + +++ +E G + G+ +P + + R G++K
Sbjct: 995 QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKV 1054
Query: 516 GDVLLNINGIDLTNLSHSEAVAMLKASA------------ASPAVALKALEVQIVEEATQ 563
GD +L +NG +TN SHS+ V ++K + +S A L E T
Sbjct: 1055 GDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTH 1114
Query: 564 NAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENH 623
+Q + + N + + + + L R G +GFS+ GG E N
Sbjct: 1115 TPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG-FGFSLRGGREYN- 1172
Query: 624 TNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
++ + PA G+++ GD I+ +NG +T M HS + ++K +V L +
Sbjct: 1173 --MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLK 1230
Query: 684 CWPGSL 689
GS+
Sbjct: 1231 RGDGSV 1236
Score = 57.8 bits (138), Expect = 3e-08
Identities = 49/204 (24%), Positives = 91/204 (44%), Gaps = 14/204 (6%)
Query: 369 LLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGN 428
++EG A + G+L DR+LA+NG + + +I+ +G V L I +
Sbjct: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
Query: 429 TIREAGNHSSSSQHHTPPPYYSRPSSH----KDLTQC------VTCQEKHITVKKEPH-E 477
+ A ++ + HTP ++ + + K +Q T ++ TV+ E +
Sbjct: 1100 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1159
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
G ++ GGR + ++V + G R G+++ GD +L ING N+ HS A+
Sbjct: 1160 GFGFSLRGGR---EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1216
Query: 538 MLKASAASPAVALKALEVQIVEEA 561
++K + LK + + E A
Sbjct: 1217 LIKNGGRRVRLFLKRGDGSVPEYA 1240
Score = 49.3 bits (116), Expect = 1e-05
Identities = 28/70 (40%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 603 LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGM 662
LR+S G +GF++VGG E + Q IK++VL PA DG+++ GD+IV+VN +G
Sbjct: 475 LRKSSRG-FGFTVVGGDEPDEFLQ---IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 663 SHSALVPMLK 672
+H+ +V + +
Sbjct: 531 THAQVVKIFQ 540
Score = 47.0 bits (110), Expect = 6e-05
Identities = 44/186 (23%), Positives = 72/186 (38%), Gaps = 40/186 (21%)
Query: 273 RDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVL------------RERRF 320
R G+L GD+IL VN +I+N SH+ ++ + NT+ L ++ +
Sbjct: 1048 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI 1107
Query: 321 GNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------------------ 362
H+ S +E K++S Q K + T E
Sbjct: 1108 ATITTTHTPSQQGTQETRNTTKPKQES--QFEFKAPQATQEQDFYTVELERGAKGFGFSL 1165
Query: 363 --------GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERV 414
+++L L E G A + G++ D +L ING K A ++I+ G RV
Sbjct: 1166 RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRV 1225
Query: 415 NLTIAR 420
L + R
Sbjct: 1226 RLFLKR 1231
Score = 40.8 bits (94), Expect = 0.004
Identities = 60/261 (22%), Positives = 95/261 (36%), Gaps = 27/261 (10%)
Query: 97 KKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKN-------RCPGASHRRVALER 149
K L H + +LV CP S ++QR L K+ R + + ++
Sbjct: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSS 751
Query: 150 RKTSRTQAEIENENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNP 209
++ T + + PA +P+ P + + S S + P +P
Sbjct: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSP 811
Query: 210 AFEESAGA------DTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQ 263
A S G T +P+ + I + R G I+GGNE P I I
Sbjct: 812 ASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKET--GFGFRILGGNE-PGEPIYIG 868
Query: 264 EVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLH--LTVLR----- 316
+ G DGRL +GD+++ V+ + SH ++ Q H LTV R
Sbjct: 869 HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFA 928
Query: 317 ----ERRFGNRAHNHSDSNSP 333
E + A +H SN P
Sbjct: 929 VPKTENEVPSPASSHHSSNQP 949
Score = 38.5 bits (88), Expect = 0.021
Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 223 PLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQ 282
P + E + T+E+ R G S+ GG E + ++ + + DG R G++ GD+
Sbjct: 1141 PQATQEQDFYTVELERGAK--GFGFSLRGGREYNM-DLYVLRLAEDGPAERCGKMRIGDE 1197
Query: 283 ILQVNNYNISNVSHNYA 299
IL++N N+ H+ A
Sbjct: 1198 ILEINGETTKNMKHSRA 1214
Score = 35.4 bits (80), Expect = 0.18
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 463 TCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDG-----RIKRGD 517
T + TVK+ P LG+TV G G++ GE P +V +V G R+ G+
Sbjct: 12 TSRVHECTVKRGPQGELGVTVLG--GAEHGEFP-YVGAVAAVEAAGLPGGGEGPRLGEGE 68
Query: 518 VLLNINGIDLTNLSHSEAVAMLKASAASPAVALKAL 553
+LL + G+ ++ L + + ++ + AV KA+
Sbjct: 69 LLLEVQGVRVSGLPRYDVLGVI--DSCKEAVTFKAV 102
Score = 35.0 bits (79), Expect = 0.23
Identities = 67/294 (22%), Positives = 111/294 (37%), Gaps = 70/294 (23%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G ++VGG+E P + I+ + DG A DG++ GD I+ VN+ + + H +A+ V
Sbjct: 483 GFTVVGGDE-PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV--LGHTHAQVV--- 536
Query: 306 PCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF 365
+IFQ G + ++L R P F
Sbjct: 537 ------------------------------KIFQ----SIPIGASVDLELCRGYPLP--F 560
Query: 366 ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
D L L + +NG + Y +P A +G+ + ARP P
Sbjct: 561 DPDDPNTSLVTSVAILDKEP--IIVNGQE-TYDSP---ASHSSKTGKVNGMKDARPSSP- 613
Query: 426 PGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG 485
+ +S+S H P S SS + +T + + K P G T+A
Sbjct: 614 --------ADVASNSSHGYPNDTVSLASSIATQPELIT-----VHIVKGP-MGFGFTIAD 659
Query: 486 GRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML 539
G + V S G +K GD+++ +N ++ L+H++ V ML
Sbjct: 660 SPGGGGQRVKQIVDSPRCRG-------LKEGDLIVEVNKKNVQALTHNQVVDML 706
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/82 (24%), Positives = 42/82 (51%), Gaps = 3/82 (3%)
Query: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
T ++ G TV GG + E + + S+ G A DG+++ GDV++++N +
Sbjct: 473 TKLRKSSRGFGFTVVGG--DEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 530 LSHSEAVAMLKASAASPAVALK 551
+H++ V + ++ +V L+
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLE 551
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 79.0 bits (193), Expect = 1e-14
Identities = 64/235 (27%), Positives = 106/235 (45%), Gaps = 40/235 (17%)
Query: 488 GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPA 547
G++ GE PI++ + P G DGR++ GD L+ ++G + SH V +++ +A
Sbjct: 858 GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGH 916
Query: 548 V----------ALKALEVQIVEEATQN-AEEQPSTFSENEYDASWSPSWVMWL------- 589
V A+ E ++ A+ + + QP++ +E + S + + +
Sbjct: 917 VNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST 976
Query: 590 -----------GLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTN----------QPF 628
G+ ST+ +D+ +RR +GF IV P
Sbjct: 977 SGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPH 1036
Query: 629 FIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
I I+ G+PA G+LK GD I+AVNG S SHS +V ++KE N VTL +I
Sbjct: 1037 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1091
Score = 77.8 bits (190), Expect = 3e-14
Identities = 92/427 (21%), Positives = 173/427 (40%), Gaps = 62/427 (14%)
Query: 316 RERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPG--VFILDLLEGG 373
RER + N + P + + L ++++G G +++ +EPG ++I ++ G
Sbjct: 820 REREINST--NFGECPIPDYQEQDIFLWRKETG--FGFRILGG-NEPGEPIYIGHIVPLG 874
Query: 374 LAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGER--VNLTIARP---GKPQPGN 428
A DGRL S D ++ ++G + + +L Q++Q + ++ VNLT+ R P+ N
Sbjct: 875 AADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN 934
Query: 429 TIRE-AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC----------------------- 464
+ A +H SS+Q + P ++ V+
Sbjct: 935 EVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV 994
Query: 465 QEKHITVKKEPHESLGMTVAGG----------RGSKSGELPIFVTSVPPHGCLARDGRIK 514
Q + +++ +E G + G+ +P + + R G++K
Sbjct: 995 QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLK 1054
Query: 515 RGDVLLNINGIDLTNLSHSEAVAMLKASA------------ASPAVALKALEVQIVEEAT 562
GD +L +NG +TN SHS+ V ++K + +S A L E T
Sbjct: 1055 VGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTT 1114
Query: 563 QNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEEN 622
+Q + + N + + + + L R G +GFS+ GG E N
Sbjct: 1115 HTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG-FGFSLRGGREYN 1173
Query: 623 HTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682
++ + PA G+++ GD I+ +NG +T M HS + ++K +V L +
Sbjct: 1174 ---MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1230
Query: 683 ICWPGSL 689
GS+
Sbjct: 1231 KRGDGSV 1237
Score = 62.0 bits (149), Expect = 2e-09
Identities = 52/213 (24%), Positives = 94/213 (44%), Gaps = 14/213 (6%)
Query: 369 LLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGN 428
++EG A + G+L DR+LA+NG + + +I+ +G V L I +
Sbjct: 1041 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1100
Query: 429 TIREAGNHSSSSQHHTPPPYYSRPSSH----KDLTQC------VTCQEKHITVKKEPH-E 477
+ A ++ + HTP ++ + + K +Q T ++ TV+ E +
Sbjct: 1101 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1160
Query: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
G ++ GGR + ++V + G R G+++ GD +L ING N+ HS A+
Sbjct: 1161 GFGFSLRGGR---EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1217
Query: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPS 570
++K + LK + + E N E PS
Sbjct: 1218 LIKNGGRRVRLFLKRGDGSVPEYGGSNYENIPS 1250
Score = 49.3 bits (116), Expect = 1e-05
Identities = 28/70 (40%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 603 LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGM 662
LR+S G +GF++VGG E + Q IK++VL PA DG+++ GD+IV+VN +G
Sbjct: 475 LRKSSRG-FGFTVVGGDEPDEFLQ---IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
Query: 663 SHSALVPMLK 672
+H+ +V + +
Sbjct: 531 THAQVVKIFQ 540
Score = 47.0 bits (110), Expect = 6e-05
Identities = 44/186 (23%), Positives = 72/186 (38%), Gaps = 40/186 (21%)
Query: 273 RDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVL------------RERRF 320
R G+L GD+IL VN +I+N SH+ ++ + NT+ L ++ +
Sbjct: 1049 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI 1108
Query: 321 GNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------------------ 362
H+ S +E K++S Q K + T E
Sbjct: 1109 ATITTTHTPSQQGTQETRNTTKPKQES--QFEFKAPQATQEQDFYTVELERGAKGFGFSL 1166
Query: 363 --------GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERV 414
+++L L E G A + G++ D +L ING K A ++I+ G RV
Sbjct: 1167 RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRV 1226
Query: 415 NLTIAR 420
L + R
Sbjct: 1227 RLFLKR 1232
Score = 38.5 bits (88), Expect = 0.021
Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 223 PLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQ 282
P + E + T+E+ R G S+ GG E + ++ + + DG R G++ GD+
Sbjct: 1142 PQATQEQDFYTVELERGAK--GFGFSLRGGREYNM-DLYVLRLAEDGPAERCGKMRIGDE 1198
Query: 283 ILQVNNYNISNVSHNYA 299
IL++N N+ H+ A
Sbjct: 1199 ILEINGETTKNMKHSRA 1215
Score = 35.4 bits (80), Expect = 0.18
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 463 TCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDG-----RIKRGD 517
T + TVK+ P LG+TV G G++ GE P +V +V G R+ G+
Sbjct: 12 TSRVHECTVKRGPQGELGVTVLG--GAEHGEFP-YVGAVAAVEAAGLPGGGEGPRLGEGE 68
Query: 518 VLLNINGIDLTNLSHSEAVAMLKASAASPAVALKAL 553
+LL + G+ ++ L + + ++ + AV KA+
Sbjct: 69 LLLEVQGVRVSGLPRYDVLGVI--DSCKEAVTFKAV 102
Score = 35.0 bits (79), Expect = 0.23
Identities = 67/294 (22%), Positives = 111/294 (37%), Gaps = 70/294 (23%)
Query: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
G ++VGG+E P + I+ + DG A DG++ GD I+ VN+ + + H +A+ V
Sbjct: 483 GFTVVGGDE-PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV--LGHTHAQVV--- 536
Query: 306 PCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF 365
+IFQ G + ++L R P F
Sbjct: 537 ------------------------------KIFQ----SIPIGASVDLELCRGYPLP--F 560
Query: 366 ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
D L L + +NG + Y +P A +G+ + ARP P
Sbjct: 561 DPDDPNTSLVTSVAILDKEP--IIVNGQE-TYDSP---ASHSSKTGKVNGMKDARPSSP- 613
Query: 426 PGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG 485
+ +S+S H P S SS + +T + + K P G T+A
Sbjct: 614 --------ADVASNSSHGYPNDTVSLASSIATQPELIT-----VHIVKGP-MGFGFTIAD 659
Query: 486 GRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML 539
G + V S G +K GD+++ +N ++ L+H++ V ML
Sbjct: 660 SPGGGGQRVKQIVDSPRCRG-------LKEGDLIVEVNKKNVQALTHNQVVDML 706
Score = 31.2 bits (69), Expect = 3.4
Identities = 20/82 (24%), Positives = 42/82 (51%), Gaps = 3/82 (3%)
Query: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
T ++ G TV GG + E + + S+ G A DG+++ GDV++++N +
Sbjct: 473 TKLRKSSRGFGFTVVGG--DEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
Query: 530 LSHSEAVAMLKASAASPAVALK 551
+H++ V + ++ +V L+
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLE 551
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,339,825
Number of Sequences: 37866
Number of extensions: 1458959
Number of successful extensions: 5369
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 354
Number of HSP's successfully gapped in prelim test: 106
Number of HSP's that attempted gapping in prelim test: 3904
Number of HSP's gapped (non-prelim): 1267
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.