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Search of human proteins with 119709832
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
(1615 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119709832 low density lipoprotein receptor-related protein 5 ... 3371 0.0
gi|148727288 low density lipoprotein receptor-related protein 6 ... 2366 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 1026 0.0
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 810 0.0
gi|93102379 low density lipoprotein-related protein 1B precursor... 747 0.0
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 680 0.0
gi|32698824 low density lipoprotein receptor-related protein 5-l... 399 e-110
gi|209447022 low density lipoprotein receptor-related protein 5-... 399 e-110
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 248 3e-65
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 246 1e-64
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 242 2e-63
gi|61744467 low density lipoprotein receptor-related protein 8 i... 241 5e-63
gi|61744471 low density lipoprotein receptor-related protein 8 i... 239 2e-62
gi|66082554 low density lipoprotein receptor-related protein 8 i... 239 2e-62
gi|65301119 low density lipoprotein receptor-related protein 8 i... 239 2e-62
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 228 4e-59
gi|4507157 sortilin-related receptor containing LDLR class A rep... 198 4e-50
gi|115298674 nidogen 1 precursor [Homo sapiens] 191 4e-48
gi|144953895 nidogen 2 precursor [Homo sapiens] 178 4e-44
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 110 8e-24
gi|28557796 low density lipoprotein receptor class A domain cont... 108 4e-23
gi|29244926 corin [Homo sapiens] 102 4e-21
gi|134031945 SCO-spondin [Homo sapiens] 98 7e-20
gi|11415040 matriptase [Homo sapiens] 97 2e-19
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 92 3e-18
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 92 3e-18
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 92 3e-18
gi|208973262 low density lipoprotein-related protein 12 isoform ... 89 3e-17
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 89 3e-17
gi|167555125 low density lipoprotein receptor-related protein 3 ... 88 8e-17
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 3371 bits (8740), Expect = 0.0
Identities = 1615/1615 (100%), Positives = 1615/1615 (100%)
Query: 1 MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVS 60
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVS
Sbjct: 1 MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVS 60
Query: 61 GLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGK 120
GLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGK
Sbjct: 61 GLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGK 120
Query: 121 KLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG 180
KLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG
Sbjct: 121 KLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAG 180
Query: 181 MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHP 240
MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHP
Sbjct: 181 MDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHP 240
Query: 241 FALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE 300
FALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE
Sbjct: 241 FALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE 300
Query: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP 360
EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP 360
Query: 361 DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDG 420
DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDG
Sbjct: 361 DFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDG 420
Query: 421 IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE 480
IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE
Sbjct: 421 IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE 480
Query: 481 NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL 540
NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL
Sbjct: 481 NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL 540
Query: 541 LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVV 600
LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVV
Sbjct: 541 LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVV 600
Query: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 660
GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL
Sbjct: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 660
Query: 661 ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP 720
ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP
Sbjct: 661 ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP 720
Query: 721 EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEW 780
EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEW
Sbjct: 721 EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEW 780
Query: 781 GGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVV 840
GGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVV
Sbjct: 781 GGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVV 840
Query: 841 IADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ 900
IADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ
Sbjct: 841 IADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ 900
Query: 901 DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMI 960
DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMI
Sbjct: 901 DGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMI 960
Query: 961 PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQ 1020
PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQ
Sbjct: 961 PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQ 1020
Query: 1021 NPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY 1080
NPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY
Sbjct: 1021 NPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGY 1080
Query: 1081 LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCD 1140
LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCD
Sbjct: 1081 LYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCD 1140
Query: 1141 LSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTG 1200
LSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTG
Sbjct: 1141 LSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTG 1200
Query: 1201 IHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1260
IHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS
Sbjct: 1201 IHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1260
Query: 1261 PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE 1320
PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE
Sbjct: 1261 PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE 1320
Query: 1321 ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS 1380
ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS
Sbjct: 1321 ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS 1380
Query: 1381 PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP 1440
PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP
Sbjct: 1381 PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAP 1440
Query: 1441 GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNP 1500
GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNP
Sbjct: 1441 GGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNP 1500
Query: 1501 PPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKAS 1560
PPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKAS
Sbjct: 1501 PPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKAS 1560
Query: 1561 KYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS 1615
KYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS
Sbjct: 1561 KYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS 1615
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 2366 bits (6131), Expect = 0.0
Identities = 1130/1615 (69%), Positives = 1337/1615 (82%), Gaps = 20/1615 (1%)
Query: 16 LLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKG 75
+L L C A+PLLL+ANRRD+RLVDA K +TIVV GLEDAAAVDF FS G
Sbjct: 4 VLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHG 63
Query: 76 AVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVA 135
+YW+DVSEEAIK+T N+T +VQNVV+SGL+SPDGLACDW+G+KLYWTDSETNRIEV+
Sbjct: 64 LIYWSDVSEEAIKRTEFNKT-ESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVS 122
Query: 136 NLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIY 195
NL+G+ RKVLFWQ+LDQPRAIALDP+ G+MYWTDWGE P+IERAGMDGS+R II++S+IY
Sbjct: 123 NLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIY 182
Query: 196 WPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDW 255
WPNGLT+D EEQKLYWADAKL+FIH++NLDG+ RQ VV+GSL HPFALTL D LYWTDW
Sbjct: 183 WPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDW 242
Query: 256 QTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPS 315
T SI ACNK TG +EI S ++SPMDI SQ+RQP C DNGGCSHLCL+SP
Sbjct: 243 STHSILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPV 302
Query: 316 EPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHA 375
+PFY CACPTGV+L +NG+TCK GA E+LLLARRTDLRRISLDTPDFTDIVLQ++DIRHA
Sbjct: 303 KPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
Query: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435
IAIDYDP+EGY+YWTDDEVRAIRR+++DGSG+Q +V +I PDGIAVDWVARNLYWTDT
Sbjct: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDT 422
Query: 436 GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERR 495
GTDRIEVTRLNGT RKIL+SEDL+EPRAI L P++G MYWTDWGE PKIE A LDG +R
Sbjct: 423 GTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRV 482
Query: 496 VLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLG 555
VLVN SLGWPNGLALD EGK+YWGDAKTDKIEV+N DGT RR L+EDK+PHIFGFTLLG
Sbjct: 483 VLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLG 542
Query: 556 DFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHL 615
D++YWTDWQRRSIERVHK A R+VIIDQLPDLMGLKA NV +V+G+NPCA+ NGGCSHL
Sbjct: 543 DYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHL 602
Query: 616 CFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVK 675
C + P RC CPIG EL+SDMKTCIVPEAFL+F+ RA I RISLETNNN+VAIPLTGVK
Sbjct: 603 CLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVK 662
Query: 676 EASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWA 735
EASALDFDV++N IYWTD+SLKTISRAFMNGS++EHVVEFGLDYPEGMAVDW+GKNLYWA
Sbjct: 663 EASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWA 722
Query: 736 DTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTN 795
DTGTNRIEV++LDGQ RQVLVW+DLD+PR+LALDP +G++YWTEWGGKP+I RA MDG+
Sbjct: 723 DTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSE 782
Query: 796 CMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYS 855
TLV VGRAN LTIDYA +RLYWTDLDTN+IESSNMLG R VIADDLPHPFGLTQY
Sbjct: 783 RTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQ 842
Query: 856 DYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQ 915
DYIYWTDW+ SIERA+KTSG+NRT+IQGHLD+VMDILVFHSSRQ G N+C +NG C
Sbjct: 843 DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQSGWNECASSNGHCSH 902
Query: 916 LCLAIP-GGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLH 974
LCLA+P GG CGC +HY+L+ +R CS PTTFLLFSQKSAI+RM+ D+Q SPD+ILP+H
Sbjct: 903 LCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILPIH 962
Query: 975 GLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPF-VLTSLSQGQNPDRQPHDLSID 1032
LRNV+AIDYDPLDK +YW+D RQN I++A++DG+Q F V+ S QN + QP+DLSID
Sbjct: 963 SLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSID 1022
Query: 1033 IYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAK 1092
IYSR ++WTCEATN INV RL G ++GVVL+G++D+PRA+VVN E+GY+YFTN+Q+R+ K
Sbjct: 1023 IYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPK 1082
Query: 1093 IERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDA 1152
IERAALDGTEREVLF +GL +P+AL +D+ LGKLFW D+DL+RIES DLSGANR+ LED+
Sbjct: 1083 IERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLEDS 1142
Query: 1153 NIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEF 1212
NI+QP+GLT+ LYWID+QQQMIE+++ T + RT++Q R+A L+ IHAV+E++L+E+
Sbjct: 1143 NILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEY 1202
Query: 1213 SAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEID 1272
HPCA+DNGGCSHIC+ KGDGT RCSCP+HLVLLQ+ L+CGEPPTCSP QF C TGEID
Sbjct: 1203 RQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID 1262
Query: 1273 CIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1332
CIP AWRCDGF EC+D SDE CPVCS +QF CA GQC+D LRC+G+A+CQD+SDE +C
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Query: 1333 DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIG 1392
+ +CL +QFRCA+GQC+ ++CD DC D SDEL C T+ P +P ++ +G VIG
Sbjct: 1323 EVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEP---APQATNTVGSVIG 1379
Query: 1393 IILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEY-VSGTPHVPLNFIAPGGSQHGPFTGI 1451
+I+++FV G VYF+CQR++C R G ++Y V G VPL ++ S G G+
Sbjct: 1380 VIVTIFVSGTVYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGM 1439
Query: 1452 ACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLY 1511
+ GKSM+SS+S+MGG G P YDR HVTGASSSSSSSTK T +P ILNPPPSPAT+ S Y
Sbjct: 1440 SRGKSMISSLSIMGGSSGPP-YDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHY 1498
Query: 1512 NMDMFYSSNIPATAR--PYRPYIIRGMAPPTTPCSTDVCDSDYSASR-----WKASKYYL 1564
M+ YSSN P+T R YRPY R APPTTPCSTDVCDSDY+ SR A Y
Sbjct: 1499 TMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTS 1558
Query: 1565 DLNSDSDPYPPPPTPHSQYLSAE---DSCPPSPATERSY-FHLFPPPPSPCTDSS 1615
DLN DS+P PPPPTP SQYLSAE +SCPPSP TERSY HL+PPPPSPCTDSS
Sbjct: 1559 DLNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS 1613
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 1026 bits (2652), Expect = 0.0
Identities = 533/1218 (43%), Positives = 754/1218 (61%), Gaps = 26/1218 (2%)
Query: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
P+LLFANR D+R V + E T++++ LE+A A+DF + V+W+DV+ + I + L
Sbjct: 440 PVLLFANRIDIRQVLPH--RSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANL 497
Query: 93 NQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQ 152
N G+ V+ VV +GL SP GLA DWV KLYWTDS T+RIEVANL+G RKVL WQ+L++
Sbjct: 498 N--GSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEK 555
Query: 153 PRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWA 212
PRAIAL P G +YWTDWG TPRIE + MDGS R+II D+ ++WPNGLTID +++YW
Sbjct: 556 PRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWV 615
Query: 213 DAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRK 272
DAK I RANLDGS R+ V+ L HPFA+T+ D+LYWTDW T+SI++ NK TG ++
Sbjct: 616 DAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQE 675
Query: 273 EILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDN 332
I + L+ PMDI L +RQP RC ++NGGC+HLCL PS YTCACPTG + + +
Sbjct: 676 IIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL--PSGQNYTCACPTGFR-KIS 732
Query: 333 GRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDD 392
C ++ LL ARR D+RRIS DT D +D V+ + D+R A+A+D+D + +VYWTD
Sbjct: 733 SHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDV 792
Query: 393 EVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKI 452
I RA DG+G + +V+T + P G+A+DWV LYWTD GTDRIEV +G+ R +
Sbjct: 793 STDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTV 852
Query: 453 LVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDL 512
L+ E+LD PR I + P+ G MYWTDWG +PKIE A +D R+V+++++L WPNGLA+D
Sbjct: 853 LIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 912
Query: 513 QEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVH 572
+LYW DA IE +DG+KR+ L+ +LPH FG TL G+ IYWTDWQ +SI+
Sbjct: 913 GSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSAD 972
Query: 573 KVKA-SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHAT--RCGCPI 629
++ R+ + + L +LM + + + + PCA NGGCSHLC +P+ + C CP
Sbjct: 973 RLTGLDRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPT 1032
Query: 630 GLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNN-NDVAIPLT-GVKEASALDFDVSN 686
G+ LLSD KTC +FL+F R I +SL+ DV +P+ +K A+ D
Sbjct: 1033 GINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQE 1092
Query: 687 NHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVAR 746
+YW+D +L ISRA ++GS E ++ GL +G+AVD +G+ +YW DTGTNRIEV
Sbjct: 1093 GKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGN 1152
Query: 747 LDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGR 805
LDG R+VLVW++LD+PR++ L G++YWT+WG ++ R+ MDG++ L+ + +G
Sbjct: 1153 LDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRAVLINNNLGW 1212
Query: 806 ANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNL 865
N LT+D A +L W D T IE++++ G R + + HP+GLT YIYWTDW
Sbjct: 1213 PNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQT 1272
Query: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHR 925
SI RADK +G N L++ +L +MD+ ++ G N C NG C LCL P G
Sbjct: 1273 RSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFS 1332
Query: 926 CGCASHYTLDPSSRNCSP-PTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDY 984
C C + L + C P P T+LLFS + +I R+ D D+ +P+ L NV ++DY
Sbjct: 1333 CACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDY 1392
Query: 985 DPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCE 1043
D +D +Y+ D + I+RA +G+ + T + +G + L++D +R L+WT
Sbjct: 1393 DSVDGKVYYTDVFLDVIRRADLNGSN--METVIGRGL---KTTDGLAVDWVARNLYWTDT 1447
Query: 1044 ATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTER 1103
NTI RL G V++ D+PRAI V +GYL++T+ AKIERA LDG+ER
Sbjct: 1448 GRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDW-GHIAKIERANLDGSER 1506
Query: 1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL 1163
+VL T L P L +D +++WVDA L RIES DL+G R L +++ P LT
Sbjct: 1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV-SHVSHPFALTQQ 1565
Query: 1164 GKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGG 1223
+ +YW D Q + I+RV+K +G + + V L I V + + C +NGG
Sbjct: 1566 DRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVS--PQRQTGTNACGVNNGG 1623
Query: 1224 CSHICIAKGDGTPRCSCP 1241
C+H+C A+ C+CP
Sbjct: 1624 CTHLCFARASDFV-CACP 1640
Score = 870 bits (2248), Expect = 0.0
Identities = 436/936 (46%), Positives = 600/936 (64%), Gaps = 24/936 (2%)
Query: 23 CGCP-------APAAASPL---LLFANRRDVRLVDAGGVKLESTIV-VSGLEDAAAVDFQ 71
C CP + A A L LLFA R D+R + L ++ ++ + A A+D+
Sbjct: 722 CACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWD 781
Query: 72 FSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNR 131
VYWTDVS + I + + TG V VV + L SP GLA DWV KLYWTD+ T+R
Sbjct: 782 SRDDHVYWTDVSTDTISRAKWDGTGQEV--VVDTSLESPAGLAIDWVTNKLYWTDAGTDR 839
Query: 132 IEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVD 191
IEVAN +G+ R VL W++LD+PR I ++P GYMYWTDWG +P+IERAGMD S R++I+
Sbjct: 840 IEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIIS 899
Query: 192 SDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLY 251
S++ WPNGL ID Q+LYWADA + I A LDGS R+ ++ L HPF LTL G+ +Y
Sbjct: 900 SNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIY 959
Query: 252 WTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCL 311
WTDWQT+SI + ++ TG R+ + L + MDI V + R P T C +NGGCSHLCL
Sbjct: 960 WTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPV-STPCAMENGGCSHLCL 1018
Query: 312 LSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVD- 370
SP+ ++C CPTG+ L +G+TC G L+ ARR D+R +SLD P F D+V+ ++
Sbjct: 1019 RSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINI 1078
Query: 371 DIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNL 430
+++ IAI DP EG VYW+D + I RA LDGS + ++ T + DG+AVD + R +
Sbjct: 1079 TMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRKV 1138
Query: 431 YWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLD 490
YWTDTGT+RIEV L+G+ RK+LV ++LD PRAI L+ MG MYWTDWGEN K+E + +D
Sbjct: 1139 YWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMD 1198
Query: 491 GQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFG 550
G +R VL+N +LGWPNGL +D +L W DA T++IE +++G R TL+ + H +G
Sbjct: 1199 GSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSP-VQHPYG 1257
Query: 551 FTLLGDFIYWTDWQRRSIERVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRN 609
TLL +IYWTDWQ RSI R K S +++ LP LM ++AV+ A+ +G N C RN
Sbjct: 1258 LTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRN 1317
Query: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIV-PEAFLVFTSRAAIHRISLETNNN-DV 667
GGCSHLC P C CP G++L D KTC PE +L+F+SR +I RISL+T+++ DV
Sbjct: 1318 GGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDPSPETYLLFSSRGSIRRISLDTSDHTDV 1377
Query: 668 AIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDW 727
+P+ + +LD+D + +Y+TDV L I RA +NGS++E V+ GL +G+AVDW
Sbjct: 1378 HVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGLAVDW 1437
Query: 728 MGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIV 787
+ +NLYW DTG N IE +RLDG R+VL+ LD PR++A+ P KGY++WT+WG +I
Sbjct: 1438 VARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIE 1497
Query: 788 RAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLP 846
RA +DG+ L++ +G N LT+DY +R+YW D + IES+++ G+ R V+ +
Sbjct: 1498 RANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVS 1557
Query: 847 HPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDC 906
HPF LTQ +IYWTDW SI+R DK SGRN+ + +++ +MDI+V RQ G N C
Sbjct: 1558 HPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNAC 1617
Query: 907 MHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCS 942
NNG C LC A C C +P SR CS
Sbjct: 1618 GVNNGGCTHLCFARASDFVCACPD----EPDSRPCS 1649
Score = 712 bits (1839), Expect = 0.0
Identities = 387/972 (39%), Positives = 562/972 (57%), Gaps = 31/972 (3%)
Query: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISL 357
C E+ G CS C + SE + C C TG +L+ + R+CKA G E VLL A R D+R++
Sbjct: 399 CAEE-GYCSQGC--TNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQV-- 453
Query: 358 DTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEIND 417
P ++ L ++++ +AIA+D+ V+W+D + I RA L+GS + +V+T +
Sbjct: 454 -LPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLES 512
Query: 418 PDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTD 477
P G+AVDWV LYWTD+GT RIEV L+G RK+L+ ++L++PRAIALHP+ G +YWTD
Sbjct: 513 PGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTD 572
Query: 478 WGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKR 537
WG P+IE +++DG RR++ + L WPNGL +D ++YW DAK IE N+DG+ R
Sbjct: 573 WGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Query: 538 RTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNV 596
+ ++ LPH F T+ D +YWTDW +SI +K ++++I ++L M + ++
Sbjct: 633 KAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHP 692
Query: 597 AK-VVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAI 655
+ G N C D NGGC+HLC + C CP G +S + FL+F R I
Sbjct: 693 QRQPAGKNRCGDNNGGCTHLCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDI 752
Query: 656 HRISLETNN-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVE 714
RIS +T + +D IPL V+ A ALD+D ++H+YWTDVS TISRA +G+ E VV+
Sbjct: 753 RRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVD 812
Query: 715 FGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGY 774
L+ P G+A+DW+ LYW D GT+RIEVA DG R VL+W +LD PR + ++P GY
Sbjct: 813 TSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGY 872
Query: 775 IYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNM 833
+YWT+WG P+I RA MD + ++ + N L IDY QRLYW D IE + +
Sbjct: 873 MYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGL 932
Query: 834 LGQER-VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDI 892
G +R V+I LPHPFGLT Y + IYWTDW SI+ AD+ +G +R +Q +L+ +MDI
Sbjct: 933 DGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDI 992
Query: 893 LVFHSSRQDGLNDCMHNNGQCGQLCLAI--PGGHRCGCASHYTLDPSSRNCSP-PTTFLL 949
VFH R C NG C LCL P G C C + L + CSP +FL+
Sbjct: 993 HVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLI 1052
Query: 950 FSQKSAISRMIPDDQHSPDLILPLH-GLRNVKAIDYDPLDKFIYWVDGR-QNIKRAKDDG 1007
F+++ I + D + D+++P++ ++N AI DP + +YW D I RA DG
Sbjct: 1053 FARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDG 1112
Query: 1008 TQ--PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGD 1065
+Q + T L Q D L++D R ++WT TN I V L G V++ +
Sbjct: 1113 SQHEDIITTGL---QTTD----GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQN 1165
Query: 1066 RDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGK 1125
D PRAIV+ E G++Y+T+ + AK+ER+ +DG++R VL L P L VD +
Sbjct: 1166 LDSPRAIVLYHEMGFMYWTDWGEN-AKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQ 1224
Query: 1126 LFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG 1185
L W DA +RIE+ DL+GANR TL + + P GLT+L ++YW D Q + I R +K TG
Sbjct: 1225 LLWADAHTERIEAADLNGANRHTLV-SPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTG 1283
Query: 1186 DKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLV 1245
++ + L + AV+ + + C NGGCSH+C+ + G C+CP +
Sbjct: 1284 SNVILVRSNLPGLMDMQAVDRA--QPLGFNKCGSRNGGCSHLCLPRPSGF-SCACPTGIQ 1340
Query: 1246 LLQNLLTCGEPP 1257
L + TC P
Sbjct: 1341 LKGDGKTCDPSP 1352
Score = 436 bits (1122), Expect = e-122
Identities = 255/708 (36%), Positives = 370/708 (52%), Gaps = 63/708 (8%)
Query: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC-------------------- 640
G C NGGC+ C A +C C G L D TC
Sbjct: 354 GEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSE 413
Query: 641 ----------------------IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
+ PE L+F +R I ++ + ++ + L ++ A
Sbjct: 414 GAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVL--PHRSEYTLLLNNLENAI 471
Query: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 738
ALDF ++W+DV+L I RA +NGS+VE VV GL+ P G+AVDW+ LYW D+G
Sbjct: 472 ALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSG 531
Query: 739 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMT 798
T+RIEVA LDG R+VL+W++L+ PR++AL P +G IYWT+WG PRI + MDG+
Sbjct: 532 TSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRI 591
Query: 799 LVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSD 856
+ D + N LTIDYA +R+YW D ++IE +N+ G R VI+ LPHPF +T + D
Sbjct: 592 IADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFED 651
Query: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQD-GLNDCMHNNGQCGQ 915
+YWTDW+ SI A+K +G+N+ +I+ L F MDI H RQ G N C NNG C
Sbjct: 652 SLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTH 711
Query: 916 LCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG 975
LCL + C C + + S FLLF+++ I R+ D + D ++PL
Sbjct: 712 LCLPSGQNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLAD 771
Query: 976 LRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIY 1034
+R+ A+D+D D +YW D I RAK DGT V+ S P L+ID
Sbjct: 772 VRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSL-----ESPAGLAIDWV 826
Query: 1035 SRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIE 1094
+ L+WT T+ I V G V++ + D+PR IVV GY+Y+T+ + KIE
Sbjct: 827 TNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDW-GASPKIE 885
Query: 1095 RAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANI 1154
RA +D + R+V+ ++ L P L +D +L+W DA +K IE L G+ R L + +
Sbjct: 886 RAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQL 945
Query: 1155 VQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSA 1214
P GLT+ G+ +YW D Q + I+ ++ TG R +Q + +L IH +
Sbjct: 946 PHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHR--RRPPVS 1003
Query: 1215 HPCARDNGGCSHICIAKGDGTP-RCSCPVHLVLLQNLLTCGEPPTCSP 1261
PCA +NGGCSH+C+ + + C+CP + NLL+ G+ TCSP
Sbjct: 1004 TPCAMENGGCSHLCLRSPNPSGFSCTCPTGI----NLLSDGK--TCSP 1045
Score = 115 bits (289), Expect = 3e-25
Identities = 69/195 (35%), Positives = 94/195 (48%), Gaps = 27/195 (13%)
Query: 1197 HLTGIHAVEEVSLEEFSAHPCARDNGGCSH-ICIAKG----------DGTPRCSCPVHLV 1245
H G + + S E+ C+ CS CIA+ DG+ +CP
Sbjct: 128 HCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP---- 183
Query: 1246 LLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---CSAAQ 1302
+ P C+ ++F CA G CI + CDG +C D SDE C C + +
Sbjct: 184 ------SAVPAPPCNLEEFQCAYGR--CILDIYHCDGDDDCGDWSDESDCSSHQPCRSGE 235
Query: 1303 FPCARGQCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDC 1361
F C G C++ RCDG+ADC D+SDE +C ++C QFRC SG+CV + +CD DC
Sbjct: 236 FMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDC 295
Query: 1362 IDGSDELMCEITKPP 1376
D SDE CE T P
Sbjct: 296 ADNSDEENCENTGSP 310
Score = 111 bits (278), Expect = 5e-24
Identities = 55/122 (45%), Positives = 66/122 (54%), Gaps = 6/122 (4%)
Query: 1257 PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDLR 1314
PTCSP F C G+ CI +W CDG +C+D SDE+ CP C +FPC G C+
Sbjct: 69 PTCSPLDFHCDNGK--CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSL 126
Query: 1315 LRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEIT 1373
CDG+ DC D SDE CD C +FRC+ G C+ CD DC DGSDE C
Sbjct: 127 WHCDGDNDCGDNSDE-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
Query: 1374 KP 1375
P
Sbjct: 186 VP 187
Score = 111 bits (277), Expect = 6e-24
Identities = 54/121 (44%), Positives = 69/121 (57%), Gaps = 8/121 (6%)
Query: 1253 CGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQC 1310
C C +F C +G CI WRCDG +CDDQSDE C +C+A QF C G+C
Sbjct: 225 CSSHQPCRSGEFMCDSGL--CINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC 282
Query: 1311 VDLRLRCDGEADCQDRSDEADCDAI----CLPNQFRCASGQCVLIKQQCDSFPDCIDGSD 1366
V L RCDGE DC D SDE +C+ C +QF C +G+C+ ++ C+ DC D SD
Sbjct: 283 VRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSD 342
Query: 1367 E 1367
E
Sbjct: 343 E 343
Score = 108 bits (271), Expect = 3e-23
Identities = 53/122 (43%), Positives = 66/122 (54%), Gaps = 7/122 (5%)
Query: 1259 CSPDQFACAT---GEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDL 1313
C F CA GE CIP W+CDG +C D SDE+GC P CS F C G+C+
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRR 86
Query: 1314 RLRCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
CDG+ DC+D SDE DC C ++F C +G C+ CD DC D SDE C++
Sbjct: 87 SWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDM 145
Query: 1373 TK 1374
K
Sbjct: 146 RK 147
Score = 103 bits (256), Expect = 2e-21
Identities = 53/134 (39%), Positives = 69/134 (51%), Gaps = 10/134 (7%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV------CSAAQFPCARGQCVD 1312
CS +F C+ G CI W CDG +C D SDEE CP C+ +F CA G+C+
Sbjct: 148 CSDKEFRCSDGS--CIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCIL 205
Query: 1313 LRLRCDGEADCQDRSDEADCDAI--CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
CDG+ DC D SDE+DC + C +F C SG C+ +CD DC D SDE C
Sbjct: 206 DIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
Query: 1371 EITKPPSDDSPAHS 1384
+ ++ HS
Sbjct: 266 TTSMCTAEQFRCHS 279
Score = 73.9 bits (180), Expect = 1e-12
Identities = 34/77 (44%), Positives = 45/77 (58%), Gaps = 7/77 (9%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-----PVCSAAQFPCARGQCVDL 1313
C+ +QF C +G C+ +WRCDG +C D SDEE C P C+ QF C G+C+
Sbjct: 270 CTAEQFRCHSGR--CVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQ 327
Query: 1314 RLRCDGEADCQDRSDEA 1330
R C+G DC D SDE+
Sbjct: 328 RKLCNGVNDCGDNSDES 344
Score = 61.6 bits (148), Expect = 6e-09
Identities = 32/93 (34%), Positives = 43/93 (46%), Gaps = 6/93 (6%)
Query: 1298 CSAAQFPCARGQ-----CVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLI 1351
C + F CA C+ + +CDG+ DC D SDE C C P F C +G+C+
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRR 86
Query: 1352 KQQCDSFPDCIDGSDELMCEITKPPSDDSPAHS 1384
CD DC D SDE C + D+ P +
Sbjct: 87 SWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN 119
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 810 bits (2091), Expect = 0.0
Identities = 488/1394 (35%), Positives = 750/1394 (53%), Gaps = 73/1394 (5%)
Query: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
P ++F+NR ++R +D K + +++V GL + A+DF S+ A+YWTDV E+ I + L
Sbjct: 1269 PFIIFSNRHEIRRIDLH--KGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKL 1326
Query: 93 NQTGA--AVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDL 150
GA + + V+ GL +P+GLA DW+ +YW +S ++IEVA L+GT R L D+
Sbjct: 1327 LDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDI 1386
Query: 151 DQPRAIALDPAHGYMYWTDW-GETPRIERAGMDGSTRKII--VDSDIYWPNGLTIDLEEQ 207
+ PRAIALDP G ++WTDW PRIE A M G+ R+ + WPNGLT+D E+
Sbjct: 1387 EHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEK 1446
Query: 208 KLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNK 265
++ W DA+ I+ A DGS +V+ G L+HPFA+TL G +YWTDW+T ++ NK
Sbjct: 1447 RILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANK 1506
Query: 266 RTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEED--NGGCSHLCLLSPSEPFYTCAC 323
TG + P D+QV RQP CE + G CSHLCL++ + +CAC
Sbjct: 1507 WTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRT-VSCAC 1565
Query: 324 PTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIV-LQVDDIRHAIAIDYDP 382
P ++L + TC ++ LL AR+ ++R + LD P + I+ V DI + +DYD
Sbjct: 1566 PHLMKLHKDNTTCYE-FKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDA 1624
Query: 383 LEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWT--DTGTDRI 440
E VYW+D +AI+RA+++G+G +T+V+ ++ + G+AVDWV+RNL+WT DT +I
Sbjct: 1625 REQRVYWSDVRTQAIKRAFINGTGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQI 1684
Query: 441 EVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNA 500
V RL+G+ + +V + L++P + +HP+ G +YWTD G+N I AN+DG R +L +
Sbjct: 1685 NVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTD-GDN--ISMANMDGSNRTLLFSG 1740
Query: 501 SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL--LEDKLPHIFGFTLLGDFI 558
G P GLA+D E KLYW + I N+DG+ + + +L ++GD +
Sbjct: 1741 QKG-PVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKL 1799
Query: 559 YWTDWQRRSIERVHKVKASRDVIIDQLPDL-MGLKAVNVAKVV---GTNPCADRNGGCSH 614
+W D + K S V++ L M +K + + + GTNPC+ NG CS
Sbjct: 1800 WWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQ 1859
Query: 615 LCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNN-NDVAIPLT 672
LC T TR C C G L S + C +FL+++ I I L+ N+ +D +P++
Sbjct: 1860 LCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVS 1919
Query: 673 GVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNL 732
G A +DF N+ IYW D+ L TISRA + + E VV G+ EG+AVDW+ N+
Sbjct: 1920 GTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTNGIGRVEGIAVDWIAGNI 1979
Query: 733 YWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMD 792
YW D G + IEVARL+G FR V++ + LD PR++ + P KGY++WTEWG PRI R+ +D
Sbjct: 1980 YWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLD 2039
Query: 793 GTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNM-LGQER-VVIADDLPHPF 849
GT + LV+ + N +++DY D +LYW D T+ IE ++ G+ R VV++ + F
Sbjct: 2040 GTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDMF 2099
Query: 850 GLTQYSDYIYWTDWNLH---SIERADKTSGRNRTLIQGHLDF-VMDILVFHSSRQDGLND 905
++ + D+IYW+D H SI+R K + + ++ + + DI VF+ RQ G N
Sbjct: 2100 SVSVFEDFIYWSD-RTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGTNV 2158
Query: 906 CMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRM-IPDDQ 964
C NG C QLCL G R +H L +C +LL+S+++ + + + D++
Sbjct: 2159 CAVANGGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDER 2218
Query: 965 HSPDLILPLHG---LRNVKAIDYD-------PLDKFIYWVDGR-QNIKRAKDDGTQPFVL 1013
+ + P ++NV A+ +D I++ D NI++ DDG++ +
Sbjct: 2219 NLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRR--I 2276
Query: 1014 TSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMG-------VVLRGDR 1066
T + + + + D TL+WT T+TI H + G + + GD
Sbjct: 2277 TIVENVGSVEGLAYHRGWD----TLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGD- 2331
Query: 1067 DKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKL 1126
D PRA V++ + +++TN ++ I RAAL G L + P L +D+ KL
Sbjct: 2332 DHPRAFVLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKL 2391
Query: 1127 FWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
++ DA L +IE C+ G++R + + V P GL + G+H++W D ++ ++R K G
Sbjct: 2392 YFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGS 2451
Query: 1187 KRTRIQGRVAHL-TGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLV 1245
++ + GI AV PC +NGGC +C+ G CSC +
Sbjct: 2452 NMKLLRVDIPQQPMGIIAVAN-DTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRI 2510
Query: 1246 LLQNLLTCGEPPTC-SPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE----GCPVCSA 1300
L +L +C + D+F CA GE CI + CDG P C D+SDE+ C
Sbjct: 2511 LQDDLTCRAVNSSCRAQDEFECANGE--CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKK 2568
Query: 1301 AQFPCARGQCVDLRLRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFP 1359
C+ G+CV L C+G DC D SDE C+ C +FRC G C+ +C+ F
Sbjct: 2569 TFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFV 2628
Query: 1360 DCIDGSDELMCEIT 1373
DC D SDE+ C T
Sbjct: 2629 DCEDASDEMNCSAT 2642
Score = 488 bits (1257), Expect = e-137
Identities = 326/1035 (31%), Positives = 506/1035 (48%), Gaps = 99/1035 (9%)
Query: 298 RCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGA----------------- 340
+C +NGGCSH C ++P E C+CP G++L + TC+ +
Sbjct: 1184 QCSLNNGGCSHNCSVAPGEGI-VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKF 1242
Query: 341 -------------------------EEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHA 375
+ ++ + R ++RRI L D++ + V +R+
Sbjct: 1243 SVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYS---VLVPGLRNT 1299
Query: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQT----LVNTEINDPDGIAVDWVARNLY 431
IA+D+ + +YWTD I R L +GA T ++ + P+G+AVDW+A N+Y
Sbjct: 1300 IALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIY 1359
Query: 432 WTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGEN-PKIECANLD 490
W ++ D+IEV +L+GT R L++ D++ PRAIAL P G+++WTDW + P+IE A++
Sbjct: 1360 WVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMS 1419
Query: 491 GQERRVL--VNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLL--EDKLP 546
G RR + S GWPNGL +D E ++ W DA++D I DG+ +L + L
Sbjct: 1420 GAGRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLS 1479
Query: 547 HIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQL-PDLMGLKAVNVAK-VVGTNP 604
H F TL G +YWTDW+ ++ + +K ++ + L+ + ++ + NP
Sbjct: 1480 HPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNP 1539
Query: 605 CADRNGG---CSHLCFFTPHAT-RCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 660
C + NGG CSHLC + T C CP ++L D TC + FL++ + I + L
Sbjct: 1540 C-EANGGQGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDL 1598
Query: 661 ET--NNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLD 718
+ N ++ + + + LD+D +YW+DV + I RAF+NG+ VE VV L
Sbjct: 1599 DAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGTGVETVVSADLP 1658
Query: 719 YPEGMAVDWMGKNLYWA--DTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIY 776
G+AVDW+ +NL+W DT +I VARLDG F+ +V + L+ P L + P +G +Y
Sbjct: 1659 NAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLY 1717
Query: 777 WTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQ 836
WT+ I A MDG+N L L ID+ + +LYW + I N+ G
Sbjct: 1718 WTD---GDNISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGS 1774
Query: 837 ERVVI---ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDIL 893
VI L L D ++W D + K G +++ VM +
Sbjct: 1775 GLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMK 1834
Query: 894 VFHSSRQ---DGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTLDPSSRNCSPPTTFLL 949
V+ S Q G N C NNG C QLCL R C C + Y+L + C +FLL
Sbjct: 1835 VYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLL 1894
Query: 950 FSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGT 1008
+S I + D D ++P+ G ID+ + IYWVD G I RAK D T
Sbjct: 1895 YSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQT 1954
Query: 1009 -QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRD 1067
+ V+T N + +++D + ++WT + + I V RL+G VV+ D
Sbjct: 1955 WREDVVT------NGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLD 2008
Query: 1068 KPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLF 1127
KPRAI V+ E+GYL++T + +IER+ LDGTER VL + P + VD GKL+
Sbjct: 2009 KPRAITVHPEKGYLFWTEW-GQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLY 2067
Query: 1128 WVDADLKRIESCDL-SGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
W DA +IE DL +G NR + +N + +++ +YW DR +++ + D
Sbjct: 2068 WCDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHAN-GSIKRGSKD 2126
Query: 1187 KRTRIQGRVAHLTGIHAVEEVSLEEFS------AHPCARDNGGCSHICIAKGDGTPRCSC 1240
T V TGI V+ ++ F+ + CA NGGC +C+ +G G C+C
Sbjct: 2127 NAT---DSVPLRTGI-GVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACAC 2182
Query: 1241 PVHLVLLQNLLTCGE 1255
H +L ++ +C E
Sbjct: 2183 -AHGMLAEDGASCRE 2196
Score = 346 bits (887), Expect = 1e-94
Identities = 212/658 (32%), Positives = 349/658 (53%), Gaps = 40/658 (6%)
Query: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEA- 86
P P+LL AN +++ G ++ STI + A+DF ++ V W V + A
Sbjct: 194 PVDRPPVLLIANSQNILATYLSGAQV-STITPTSTRQTTAMDFSYANETVCWVHVGDSAA 252
Query: 87 ---IKQTYLNQTGAAVQNVVIS---GLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGT 140
+K + V I+ L + +A DW+ Y+ D +RI V N NG
Sbjct: 253 QTQLKCARMPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGD 312
Query: 141 SRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGL 200
+ L +L P+ IALDPA G +++TD+G+ P++ER MDG R +VDS I +P+G+
Sbjct: 313 TCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGI 372
Query: 201 TIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSL-THPFALTLSGDTLYWTD----- 254
T+DL + +YWADA L +I + +G RQ +++G L H + LT+ + LY T+
Sbjct: 373 TLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNAN 432
Query: 255 -WQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEEDN----GGCSH 308
Q S+ N R ++++ + + + Q RQP + CE D GGCS
Sbjct: 433 AQQKTSVIRVN-RFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSD 491
Query: 309 LCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDI 365
+CLL+ S TC C +G L +G++CK E+ L+ R +R + + +
Sbjct: 492 ICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEH 551
Query: 366 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDW 425
++ ++++ + A+D+ G++Y+ D I R +DG+ +T++ I++ +G+AVDW
Sbjct: 552 MIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDW 611
Query: 426 VARNLYWTDTGTDR-IEVTRLN--GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENP 482
+ NLYWTD G + I V RL +RK L+ + PRAI + P+ G MYWTDW E+P
Sbjct: 612 MGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDP 671
Query: 483 K------IECANLDGQERRVLVNA-SLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGT 535
K +E A +DG R + V + ++ WPNGL+LD+ G+LYW DA D+IE I ++GT
Sbjct: 672 KDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGT 731
Query: 536 KRRTLLE-DKLPHIFGFTLLGDFIYWTDWQRRSIERVHK----VKASRDVIIDQLPDLMG 590
R+ + E +L H FG G++++WT+++ S+ R+ + + ++ + P +
Sbjct: 732 DRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFE 791
Query: 591 LKAVNV-AKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFL 647
++ + + VGTN C NGGCS LC TP + +C C L +D TC+ +++
Sbjct: 792 IRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYV 849
Score = 325 bits (833), Expect = 2e-88
Identities = 245/823 (29%), Positives = 387/823 (47%), Gaps = 78/823 (9%)
Query: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIV-------PEAFLVFTSRAAIHRISLET 662
G CS LC T + CGC G L D ++C P L+ S+ + + +
Sbjct: 158 GTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNIL--ATYLS 215
Query: 663 NNNDVAIPLTGVKEASALDFDVSNNHIYWTDVS-------LKTISRAFMNGSSVEHVVEF 715
I T ++ +A+DF +N + W V LK + G EH +
Sbjct: 216 GAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTINI 275
Query: 716 GLD--YPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKG 773
L + E MA+DW+ N Y+ D +RI V +G L+ +L NP+ +ALDP G
Sbjct: 276 SLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMG 335
Query: 774 YIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSN 832
+++T++G P++ R MDG N LVD K+ + +T+D + +YW D + IE +
Sbjct: 336 KVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVD 395
Query: 833 MLGQERVVIADD--LPHPFGLTQYSDYIYWTDWNLHSIERADKTS-------GRNRTLIQ 883
G+ R I + H +GLT + +Y+Y T N + KTS +
Sbjct: 396 YEGKGRQTIIQGILIEHLYGLTVFENYLYAT--NSDNANAQQKTSVIRVNRFNSTEYQVV 453
Query: 884 GHLDFVMDILVFHSSRQDGL------NDCMHNNGQCGQLCLAIPGGHR---CGCASHYTL 934
+D + ++H RQ + ND G C +CL + H+ C C S ++L
Sbjct: 454 TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICL-LANSHKARTCRCRSGFSL 512
Query: 935 DPSSRNCSPP--TTFLLFSQ-KSAISRMIPDDQHSPD-LILPLHGLRNVKAIDYDPLDKF 990
++C P FL++ + + I R + PD ++P+ L N +A+D+ F
Sbjct: 513 GSDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGF 572
Query: 991 IYWVDGRQN-IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA-TNTI 1048
IY+ D I R K DGT+ T L G + +++D L+WT + TI
Sbjct: 573 IYFADTTSYLIGRQKIDGTER--ETILKDGIH---NVEGVAVDWMGDNLYWTDDGPKKTI 627
Query: 1049 NVHRL--SGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQD-----RAAKIERAALDGT 1101
+V RL + + ++ G PRAIVV+ G++Y+T+ ++ R ++ERA +DG+
Sbjct: 628 SVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGS 687
Query: 1102 EREVLFTT-GLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR-LTLEDANIVQPLG 1159
R++ T+ ++ P L +D G+L+WVDA RIE+ L+G +R + E + G
Sbjct: 688 HRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFG 747
Query: 1160 LTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVE--EVSLEEFSAHPC 1217
L G +L+W + + + R+E+ G + + I + + ++ + C
Sbjct: 748 LCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKC 807
Query: 1218 ARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC------GEPPTCSPDQFACATGEI 1271
+NGGCS +C+A G+ +C+C VL + +TC PP C P +FACA
Sbjct: 808 RVNNGGCSSLCLAT-PGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSR- 865
Query: 1272 DCIPGAWRCDGFPECDDQSDEEGC----PVCSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
CI W+CDG +C D SDE C + +F C +C+ R CDG+ DC +
Sbjct: 866 -CIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSE 924
Query: 1328 DE--ADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
DE A C A C PNQF CASG+C+ I CD DC D SDE
Sbjct: 925 DESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDE 967
Score = 318 bits (815), Expect = 3e-86
Identities = 215/689 (31%), Positives = 350/689 (50%), Gaps = 55/689 (7%)
Query: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAE-----EVLLLARRTDLRRISLD 358
G CS LC + ++ + C C G LQ + R+CKA E VLL+A ++ L
Sbjct: 158 GTCSQLC--TNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLS 215
Query: 359 TPDFTDIVLQVDDIRHAIAIDYDPLEGYVYW-------TDDEVRAIRRAYLDGSGAQTLV 411
+ I R A+D+ V W +++ R L G + +
Sbjct: 216 GAQVSTIT--PTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPGLKGFVDEHTI 273
Query: 412 N--TEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPV 469
N ++ + +A+DW+ N Y+ D DRI V NG + L+ +L P+ IAL P
Sbjct: 274 NISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333
Query: 470 MGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEV 529
MG +++TD+G+ PK+E ++DGQ R LV++ + +P+G+ LDL +YW DA D IEV
Sbjct: 334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEV 393
Query: 530 INVDGTKRRTLLEDKL-PHIFGFTLLGDFIYWTD------WQRRSIERVHKVKASRDVII 582
++ +G R+T+++ L H++G T+ +++Y T+ Q+ S+ RV++ ++ ++
Sbjct: 394 VDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNSTEYQVV 453
Query: 583 DQLPDLMGLKAVNVAKV--VGTNPCAD----RNGGCSHLCFF--TPHATRCGCPIGLELL 634
++ L + + V ++ C + + GGCS +C + A C C G L
Sbjct: 454 TRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLG 513
Query: 635 SDMKTCIVP--EAFLVF-TSRAAIHR-ISLETNNNDV-AIPLTGVKEASALDFDVSNNHI 689
SD K+C P E FLV+ R I R + + D IP+ + ALDF I
Sbjct: 514 SDGKSCKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFI 573
Query: 690 YWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNR-IEVARLD 748
Y+ D + I R ++G+ E +++ G+ EG+AVDWMG NLYW D G + I VARL+
Sbjct: 574 YFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLE 633
Query: 749 --GQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKP------RIVRAFMDGTNCMTLV 800
Q R+ L+ + +PR++ +DP G++YWT+W P R+ RA+MDG++ V
Sbjct: 634 KAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFV 693
Query: 801 DK--VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIAD--DLPHPFGLTQYSD 856
V N L++D RLYW D + IE+ + G +R ++ + +L H FGL + +
Sbjct: 694 TSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGN 753
Query: 857 YIYWTDWNLHSIERADKTSG---RNRTLIQGHLDFVMDILVFHSSRQD-GLNDCMHNNGQ 912
Y++WT++ S+ R ++ G TL++ + +I ++ + +Q G N C NNG
Sbjct: 754 YLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGG 813
Query: 913 CGQLCLAIPGGHRCGCASHYTLDPSSRNC 941
C LCLA PG +C CA LD C
Sbjct: 814 CSSLCLATPGSRQCACAEDQVLDADGVTC 842
Score = 284 bits (727), Expect = 4e-76
Identities = 143/313 (45%), Positives = 197/313 (62%), Gaps = 4/313 (1%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C A P L+FANR +R ++ G T++ GL +A A+DF + + +YWTDV+
Sbjct: 3021 CKAVTDEEPFLIFANRYYLRKLNLDGSNY--TLLKQGLNNAVALDFDYREQMIYWTDVTT 3078
Query: 85 EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKV 144
+ ++ G+ VQ + +GL +PDGLA DWVG LYW D + IEV+ LNG R V
Sbjct: 3079 QGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTV 3138
Query: 145 LFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDL 204
L L +PRA+ +D +GY+YWTDWG+ I R GMDGS+R +IVD+ I WPNGLT+D
Sbjct: 3139 LVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDY 3198
Query: 205 EEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACN 264
+++YWADA+ +I A+LDGS R V+ + H FALTL D +YWTDW+T+SI+ +
Sbjct: 3199 VTERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAH 3258
Query: 265 KRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEEDNGGCSHLCLLSPSEPFYTCAC 323
K TG + ++S L+ PMD+ V RQP C+ +NGGCS+LCLLSP + CAC
Sbjct: 3259 KTTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGG-HKCAC 3317
Query: 324 PTGVQLQDNGRTC 336
PT L +GRTC
Sbjct: 3318 PTNFYLGSDGRTC 3330
Score = 266 bits (679), Expect = 2e-70
Identities = 139/345 (40%), Positives = 199/345 (57%), Gaps = 14/345 (4%)
Query: 306 CSHLCLLSPSEPFYTCACPTGVQLQDNG-RTCKAGAEE--VLLLARRTDLRRISLDTPDF 362
CS C+ + Y C C G + +CKA +E L+ A R LR+++LD ++
Sbjct: 2992 CSQRCINTHGS--YKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNY 3049
Query: 363 TDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRA--IRRAYLDGSGAQTLVNTEINDPDG 420
T L + +A+A+D+D E +YWTD + IRR +L+GS Q L T +++PDG
Sbjct: 3050 T---LLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDG 3106
Query: 421 IAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGE 480
+AVDWV NLYW D G D IEV++LNG R +LVS L EPRA+ + G +YWTDWG+
Sbjct: 3107 LAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGD 3166
Query: 481 NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL 540
+ I +DG R V+V+ + WPNGL LD ++YW DA+ D IE ++DG+ R +
Sbjct: 3167 HSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVV 3226
Query: 541 LEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVK-ASRDVIIDQLPDLMGLKAVNVAKV 599
L +PHIF TL D++YWTDW+ +SI R HK ++ ++I L M L + +
Sbjct: 3227 LSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQ 3286
Query: 600 --VGTNPCADRNGGCSHLCFFTP-HATRCGCPIGLELLSDMKTCI 641
V +PC NGGCS+LC +P +C CP L SD +TC+
Sbjct: 3287 PDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCV 3331
Score = 263 bits (672), Expect = 1e-69
Identities = 147/363 (40%), Positives = 210/363 (57%), Gaps = 20/363 (5%)
Query: 590 GLKAVNVAKVVGTNPCADR----NGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEA 645
G +V + T PC+ R +G LC +A R G P + ++D E
Sbjct: 2977 GRTCADVDECSTTFPCSQRCINTHGSYKCLCV-EGYAPRGGDPHSCKAVTD------EEP 3029
Query: 646 FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLK--TISRAF 703
FL+F +R + +++L+ +N + G+ A ALDFD IYWTDV+ + I R
Sbjct: 3030 FLIFANRYYLRKLNLDGSN--YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMH 3087
Query: 704 MNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNP 763
+NGS+V+ + GL P+G+AVDW+G NLYW D G + IEV++L+G +R VLV L P
Sbjct: 3088 LNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREP 3147
Query: 764 RSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTD 822
R+L +D GY+YWT+WG I R MDG++ +VD K+ N LT+DY +R+YW D
Sbjct: 3148 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWAD 3207
Query: 823 LDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTL 881
+ IE +++ G R VV++ D+PH F LT + DY+YWTDW SI RA KT+G N+TL
Sbjct: 3208 AREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTL 3267
Query: 882 IQGHLDFVMDILVFHSSRQDGL--NDCMHNNGQCGQLCLAIP-GGHRCGCASHYTLDPSS 938
+ L MD+ VFH+ RQ + + C NNG C LCL P GGH+C C +++ L
Sbjct: 3268 LISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDG 3327
Query: 939 RNC 941
R C
Sbjct: 3328 RTC 3330
Score = 257 bits (656), Expect = 7e-68
Identities = 159/480 (33%), Positives = 243/480 (50%), Gaps = 30/480 (6%)
Query: 913 CGQLCLAIPGGHRCGCASHYTL---DPSS-RNCSPPTTFLLFSQKSAISRMIPDDQHSPD 968
C Q C+ G ++C C Y DP S + + FL+F+ + + ++ D +
Sbjct: 2992 CSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSN--- 3048
Query: 969 LILPLHGLRNVKAIDYDPLDKFIYWVDGRQN---IKRAKDDGTQPFVL--TSLSQGQNPD 1023
L GL N A+D+D ++ IYW D I+R +G+ VL T LS NPD
Sbjct: 3049 YTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLS---NPD 3105
Query: 1024 RQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYF 1083
L++D L+W + +TI V +L+G V++ +PRA+VV+ + GYLY+
Sbjct: 3106 ----GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYW 3161
Query: 1084 TNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSG 1143
T+ D + I R +DG+ R V+ T + P L +D +++W DA IE L G
Sbjct: 3162 TDWGDHSL-IGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDG 3220
Query: 1144 ANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHA 1203
+NR + +I LT+ ++YW D + + I R KTTG +T + + +H
Sbjct: 3221 SNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHV 3280
Query: 1204 VEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQ 1263
+ + HPC +NGGCS++C+ G +C+CP + L + TC C+ Q
Sbjct: 3281 FHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTC--VSNCTASQ 3338
Query: 1264 FACATGEIDCIPGAWRCDGFPECDDQSDE-EGCP--VCSAAQFPCARGQCVDLRLRCDGE 1320
F C + CIP W+CD +C D SDE CP C QF C+ G C + CDG+
Sbjct: 3339 FVCKNDK--CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGD 3396
Query: 1321 ADCQDRSDEADCDA-ICLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELMC-EITKPPS 1377
DCQD SDEA+CD +CLP+QF+C + +C+ +C+ +C DG DE C E+T P+
Sbjct: 3397 NDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPN 3456
Score = 185 bits (470), Expect = 3e-46
Identities = 115/329 (34%), Positives = 158/329 (48%), Gaps = 23/329 (6%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAA--AVDFQFSKGAVYWTDV 82
C A + +L A+ ++R + G G E A+D G VYWT+
Sbjct: 3860 CKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNW 3919
Query: 83 SEEAIKQTYL-------------NQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSET 129
I L Q V ++ ISGL P G+A DWV +YWTDS
Sbjct: 3920 HTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGR 3979
Query: 130 NRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKII 189
+ IEVA + G +RK L +D+P AI +DP G MYW+DWG P+IE A MDG+ R+ +
Sbjct: 3980 DVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETL 4039
Query: 190 VDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG--SLTHPFALTLSG 247
V +I WP GL +D ++LYWADAKLS I L+G+ + L+HPF++ +
Sbjct: 4040 VQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFE 4099
Query: 248 DTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCS 307
D +Y + + +K + L D+ + Q +QP C D C
Sbjct: 4100 DYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCE 4157
Query: 308 HLCLLSPSEPFYTCACPTGVQLQDNGRTC 336
LCLLSPS P C CP G +L DNG TC
Sbjct: 4158 WLCLLSPSGP--VCTCPNGKRL-DNG-TC 4182
Score = 181 bits (459), Expect = 5e-45
Identities = 131/381 (34%), Positives = 180/381 (47%), Gaps = 44/381 (11%)
Query: 295 FHT-----RCEEDN-----GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEE-- 342
FHT C++ N G CS LC + ++ + C+C N TCKA E
Sbjct: 3813 FHTVPGQPGCQDINECLRFGTCSQLC--NNTKGGHLCSCARNFMKTHN--TCKAEGSEYQ 3868
Query: 343 VLLLARRTDLRRISLDTPDFT-DIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAY 401
VL +A ++R + P + Q D+ A+D G VYWT+ I
Sbjct: 3869 VLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRS 3928
Query: 402 LDGSGAQTLVN----------TEIND-----PDGIAVDWVARNLYWTDTGTDRIEVTRLN 446
L + T N T +N P GIA+DWVA N+YWTD+G D IEV ++
Sbjct: 3929 LPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMK 3988
Query: 447 GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPN 506
G +RK L+S +DEP AI + P+ G MYW+DWG +PKIE A +DG R LV ++ WP
Sbjct: 3989 GENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPT 4048
Query: 507 GLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDK--LPHIFGFTLLGDFIYWTDWQ 564
GLA+D +LYW DAK I I ++GT + K L H F + D+IY +
Sbjct: 4049 GLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYI 4108
Query: 565 RRSIERVHKVKASRDVI----IDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTP 620
+ ++HK S V + D++ +V TNPC DR C LC +P
Sbjct: 4109 NNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEV--TNPC-DRK-KCEWLCLLSP 4164
Query: 621 HATRCGCPIGLELLSDMKTCI 641
C CP G L D TC+
Sbjct: 4165 SGPVCTCPNGKRL--DNGTCV 4183
Score = 160 bits (405), Expect = 9e-39
Identities = 107/376 (28%), Positives = 171/376 (45%), Gaps = 52/376 (13%)
Query: 599 VVGTNPCADRN-----GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRA 653
V G C D N G CS LC T C C + TC +
Sbjct: 3816 VPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSC--ARNFMKTHNTC---------KAEG 3864
Query: 654 AIHRISLETNNNDVAIPLTGVKEAS--------------ALDFDVSNNHIYWTDVSLKTI 699
+ +++ ++N++ G ++ A+D V +YWT+ TI
Sbjct: 3865 SEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTI 3924
Query: 700 SRAFMNGSS---------------VEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEV 744
S + ++ V H+ GL P G+A+DW+ N+YW D+G + IEV
Sbjct: 3925 SYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEV 3984
Query: 745 ARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKV 803
A++ G+ R+ L+ +D P ++ +DP +G +YW++WG P+I A MDGT TLV D +
Sbjct: 3985 AQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNI 4044
Query: 804 GRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADD---LPHPFGLTQYSDYIYW 860
L +DY ++RLYW D ++I S + G + +V AD L HPF + + DYIY
Sbjct: 4045 QWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYG 4104
Query: 861 TDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ-DGLNDCMHNNGQCGQLCLA 919
+ + + + K + G L D++++H +Q + N C + +C LCL
Sbjct: 4105 VTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPC--DRKKCEWLCLL 4162
Query: 920 IPGGHRCGCASHYTLD 935
P G C C + LD
Sbjct: 4163 SPSGPVCTCPNGKRLD 4178
Score = 125 bits (315), Expect = 3e-28
Identities = 55/115 (47%), Positives = 72/115 (62%), Gaps = 4/115 (3%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDLRL 1315
TC P QF C C+PG W+CD +C D SDEE C CS ++F CA G+C+ R
Sbjct: 3535 TCEPYQFRCKNNR--CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592
Query: 1316 RCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
+CDG+ DC D SDE DC C +QF+C SG C+ ++ +CD+ DC+DGSDE C
Sbjct: 3593 KCDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
Score = 115 bits (289), Expect = 3e-25
Identities = 150/645 (23%), Positives = 235/645 (36%), Gaps = 134/645 (20%)
Query: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLF-SQKSAISRMIP 961
+N+C+ G C QLC GGH C CA ++ ++ +L+ + + I + P
Sbjct: 3825 INECLRF-GTCSQLCNNTKGGHLCSCARNFMKTHNTCKAEGSEYQVLYIADDNEIRSLFP 3883
Query: 962 DDQHSPDLILPLHGLRNVK--AIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQG 1019
HS G +V+ A+D +YW + + TS
Sbjct: 3884 GHPHSA-YEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHR 3942
Query: 1020 QNPDR-----------QPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDK 1068
+ DR P ++ID + ++WT + I V ++ GE ++ G D+
Sbjct: 3943 RQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDE 4002
Query: 1069 PRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFW 1128
P AIVV+ RG +Y+++ + KIE AA+DGT RE L + P L VD +L+W
Sbjct: 4003 PHAIVVDPLRGTMYWSDWGNH-PKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYW 4061
Query: 1129 VDADLKRIESCDLSGANRLTLEDA--NIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
DA L I S L+G + + D+ + P + + ++Y + + ++ K
Sbjct: 4062 ADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHS 4121
Query: 1187 KRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVL 1246
+ G ++H + + + E + +PC D C +C+ G P C+CP L
Sbjct: 4122 PLVNLTGGLSHASDVVLYHQHKQPEVT-NPC--DRKKCEWLCLLSPSG-PVCTCPNGKRL 4177
Query: 1247 LQNLLTCGEPPTCSPDQFACATGEIDCIPG----------------------------AW 1278
PT PD T + C G W
Sbjct: 4178 DNGTCVPVPSPTPPPDAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCELDQCW 4237
Query: 1279 -------------------RC-DGF--PECDDQ------SDEEGCPVCSAAQFPCA---- 1306
RC GF P+C Q ++ C V Q C
Sbjct: 4238 EHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNSTCTVNQGNQPQCRCLPG 4297
Query: 1307 ----RGQCVDLRLRCDGEADCQ---DRSDEADCDAI-----CLPNQ-FRCASGQCVLIKQ 1353
R Q C+ CQ D S + C A C N+ RC G CV+ KQ
Sbjct: 4298 FLGDRCQYRQCSGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQ 4357
Query: 1354 QCDSFPDCIDG---------------------SDELMCEITKPP------------SDDS 1380
D +C DG + ++M E PP S
Sbjct: 4358 SGDVTCNCTDGRVAPSCLTCVGHCSNGGSCTMNSKMMPECQCPPHMTGPRCEEHVFSQQQ 4417
Query: 1381 PAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHE 1425
P H ++I + ++L L ++ GV F +R R GA G F H+
Sbjct: 4418 PGHIASILIPLLLLLLLVLVAGVVFWYKR----RVQGAKG-FQHQ 4457
Score = 115 bits (288), Expect = 3e-25
Identities = 113/427 (26%), Positives = 176/427 (41%), Gaps = 48/427 (11%)
Query: 980 KAIDYDPLDKFIYWVDGRQN--------IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSI 1031
+AI DPL+ ++YW D ++ ++RA DG+ + + P+ LS+
Sbjct: 651 RAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVT----SKTVLWPNGLSL 706
Query: 1032 DIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAA 1091
DI + L+W + I L+G +V G + A + YL++T + +
Sbjct: 707 DIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGP-ELNHAFGLCHHGNYLFWTEYRSGSV 765
Query: 1092 -KIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-------G 1143
++ER L + RP + + V + R+ + S G
Sbjct: 766 YRLERGVGGAPPTVTLLRSE--RPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPG 823
Query: 1144 ANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTG--DKRTRIQGRVAHLTGI 1201
+ + + ++ G+T L Y Q Q E + +R + G L
Sbjct: 824 SRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNS 883
Query: 1202 HAVEEVSLEEFSAHPCARDNGGC-SHICIAKG---DGTPRCSCPVHLVLLQNLLTCGEPP 1257
+ + H C D C ++ CI DG C ++ TC
Sbjct: 884 DEAPALCHQ----HTCPSDRFKCENNRCIPNRWLCDGDNDCGNSED----ESNATCSAR- 934
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC---PVC-SAAQFPCARGQCVDL 1313
TC P+QF+CA+G CIP +W CD +C D+SDE P C QF C G+C+++
Sbjct: 935 TCPPNQFSCASGR--CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCINI 992
Query: 1314 RLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC--- 1370
RCD + DC D SDEA C C QF+C SG+C+ CD DC D SDE
Sbjct: 993 NWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCT 1052
Query: 1371 -EITKPP 1376
+ T+PP
Sbjct: 1053 NQATRPP 1059
Score = 100 bits (250), Expect = 9e-21
Identities = 69/181 (38%), Positives = 89/181 (49%), Gaps = 26/181 (14%)
Query: 1210 EEFSAHPCARDNGGCSH-ICIA---KGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFA 1265
E + PC+ C++ CIA K DG C+ + C P C DQF
Sbjct: 3568 ESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADG------SDEKDC--TPRCDMDQFQ 3619
Query: 1266 CATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLRLRCDGEA 1321
C +G CIP WRCD +C D SDEE C C +F C C L +CDGE
Sbjct: 3620 CKSGH--CIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGED 3677
Query: 1322 DCQDRSDE--ADCDA-ICLPNQ-FRCASGQ-CVLIKQQCDSFPDCIDGSDELMCEITKPP 1376
DC D SDE +C +C PN+ FRC + + C+ I +QCD +C DG+DE CE PP
Sbjct: 3678 DCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCE---PP 3734
Query: 1377 S 1377
+
Sbjct: 3735 T 3735
Score = 97.4 bits (241), Expect = 1e-19
Identities = 68/178 (38%), Positives = 86/178 (48%), Gaps = 20/178 (11%)
Query: 1220 DNGGCS-HICIA---KGDGTPRCSCPVHLVLLQNLLTCGEPP------TCSPDQFACATG 1269
D C H+C+ K T RC + Q+ GE TC+P+QF C+
Sbjct: 3404 DEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSIT 3463
Query: 1270 EIDCIPGAWRCDGFPECDDQSDEEG-CP--VCSAAQFPCA-RGQCVDLRLRCDGEADCQD 1325
+ CIP W CD +C D SDE C C +F C G+C+ R +CDGE DC D
Sbjct: 3464 K-RCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGD 3522
Query: 1326 RSDEA--DCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDS 1380
SDE +CD C P QFRC + +CV + QCD DC D SDE C T P +S
Sbjct: 3523 GSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC--TPRPCSES 3578
Score = 92.0 bits (227), Expect = 4e-18
Identities = 57/150 (38%), Positives = 72/150 (48%), Gaps = 20/150 (13%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----------CSAAQFPCAR 1307
+CS QF C +G CIP W CDG +C D SDE C +F C
Sbjct: 1014 SCSSTQFKCNSGR--CIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRL 1071
Query: 1308 -GQCVDLRLRCDGEADCQDRSDEADCDA---ICLPN-QFRCA-SGQCVLIKQQCDSFPDC 1361
G C+ LR RCDG+ DC D SDE C+ +C P+ +F C S +C+ CD DC
Sbjct: 1072 DGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDC 1131
Query: 1362 IDGSDELMCE--ITKPPSDDSPAHSSAIGP 1389
D SDE CE +PPS ++S P
Sbjct: 1132 EDNSDEENCESLACRPPSHPCANNTSVCLP 1161
Score = 90.9 bits (224), Expect = 9e-18
Identities = 63/203 (31%), Positives = 90/203 (44%), Gaps = 28/203 (13%)
Query: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGE----------------PPTCSPDQ 1263
D GCSH C + C CG+ P C D+
Sbjct: 1007 DEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDE 1066
Query: 1264 FACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCS-AAQFPCA-RGQCVDLRLRC 1317
F C + CIP WRCDG +C D SDE+ C VC + +F C +C+ C
Sbjct: 1067 FQCRLDGL-CIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVC 1125
Query: 1318 DGEADCQDRSDEADCDAI-CLPNQFRCASGQCVLIKQQ--CDSFPDCIDGSDE-LMCEIT 1373
DG+ DC+D SDE +C+++ C P CA+ V + CD DC DGSDE +C+
Sbjct: 1126 DGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQC 1185
Query: 1374 KPPSDDSPAHSSAIGPVIGIILS 1396
++ +H+ ++ P GI+ S
Sbjct: 1186 S-LNNGGCSHNCSVAPGEGIVCS 1207
Score = 89.0 bits (219), Expect = 3e-17
Identities = 48/115 (41%), Positives = 61/115 (53%), Gaps = 6/115 (5%)
Query: 1257 PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-PVCSAAQFPCARGQCVDLRL 1315
P C + FAC +G CIP +W CD +C+ DE C CS AQF C +C+ +
Sbjct: 2694 PRCPLNYFACPSGR--CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQW 2751
Query: 1316 RCDGEADCQDRSDE-ADCDA-ICLPNQFRC-ASGQCVLIKQQCDSFPDCIDGSDE 1367
CDG DC D SDE A C+ C P+ F C + CV + CD DC DG+DE
Sbjct: 2752 LCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE 2806
Score = 87.8 bits (216), Expect = 8e-17
Identities = 58/175 (33%), Positives = 80/175 (45%), Gaps = 22/175 (12%)
Query: 1217 CARDNGGC--SHICIAKG---DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEI 1271
C + C +H+C+ + DG C+ + C TC +F C +
Sbjct: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAG---CLYNSTCDDREFMCQNRQ- 2829
Query: 1272 DCIPGAWRCDGFPECDDQSDEEG---CPVCSAAQFPCARGQCVDLRL-RCDGEADCQDRS 1327
CIP + CD +C D SDE P C ++F CA G+C+ R CDGE DC D+S
Sbjct: 2830 -CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQS 2888
Query: 1328 DEADCDAICLP--------NQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
DEA + C +QF C+SG+CV C+ DC D SDE C I +
Sbjct: 2889 DEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINE 2943
Score = 87.4 bits (215), Expect = 1e-16
Identities = 39/100 (39%), Positives = 50/100 (50%), Gaps = 5/100 (5%)
Query: 1273 CIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
C +W CDG +C D SDE CP C F C G+C+ + CD E DC+
Sbjct: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGE 2725
Query: 1328 DEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
DE C+ C QF C + +C+ + CD DC DGSDE
Sbjct: 2726 DETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765
Score = 72.0 bits (175), Expect = 4e-12
Identities = 43/109 (39%), Positives = 55/109 (50%), Gaps = 13/109 (11%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGA-WRCDGFPECDDQSDEEGC-PVCSA--------AQFP 1304
E PTC P +F CA G C+ W CDG +C DQSDE P C++ +QF
Sbjct: 2854 EYPTCGPSEFRCANGR--CLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFL 2911
Query: 1305 CARGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIK 1352
C+ G+CV L C+G+ DC D SDE C CL + S C +K
Sbjct: 2912 CSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLK 2960
Score = 65.1 bits (157), Expect = 5e-10
Identities = 37/82 (45%), Positives = 43/82 (52%), Gaps = 9/82 (10%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGCPV-----CSAAQFPCARG 1308
P TCSP QFAC +I CI WRCDG +C D SDE E CP C + C
Sbjct: 24 PKTCSPKQFACRD-QITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT 82
Query: 1309 Q-CVDLRLRCDGEADCQDRSDE 1329
+ CV + C+G DC D SDE
Sbjct: 83 ELCVPMSRLCNGVQDCMDGSDE 104
Score = 58.9 bits (141), Expect = 4e-08
Identities = 35/79 (44%), Positives = 42/79 (53%), Gaps = 10/79 (12%)
Query: 1298 CSAAQFPCARGQ--CVDLRLRCDGEADCQDRSDEAD--CDAI----CLPNQFRCASGQ-C 1348
CS QF C R Q C+ RCDGE DC D SDEA C C PN+ C + C
Sbjct: 27 CSPKQFAC-RDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
Query: 1349 VLIKQQCDSFPDCIDGSDE 1367
V + + C+ DC+DGSDE
Sbjct: 86 VPMSRLCNGVQDCMDGSDE 104
Score = 37.0 bits (84), Expect = 0.15
Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 2/45 (4%)
Query: 1217 CARDNGGCSHIC-IAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1260
C+ +NGGCSH C +A G+G CSCP+ + L + TC C+
Sbjct: 1185 CSLNNGGCSHNCSVAPGEGIV-CSCPLGMELGPDNHTCQIQSYCA 1228
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 747 bits (1929), Expect = 0.0
Identities = 464/1397 (33%), Positives = 720/1397 (51%), Gaps = 68/1397 (4%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C + ++F+ R ++R +D K + +++V GL + A+DF F++ +YWTDV E
Sbjct: 1252 CTSVDPFEAFIIFSIRHEIRRIDLH--KRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVE 1309
Query: 85 EAIKQTYLNQTG--AAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
+ I + L+++G +A++ VV GL +P+GL DW+ +YW DS ++IEVA L+G+ R
Sbjct: 1310 DRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLR 1369
Query: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDW-GETPRIERAGMDGSTRKIIVD--SDIYWPNG 199
L ++ PRAIALDP +G ++WTDW PRIE A M G+ RK I WPNG
Sbjct: 1370 TTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNG 1429
Query: 200 LTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQT 257
LT+D E+++ W DA+ I+ A DG+ +++ G L+HPFA++L G +YWTDW+T
Sbjct: 1430 LTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRT 1489
Query: 258 RSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRC--EEDNGGCSHLCLLSPS 315
++ NK TG I P D+Q+ RQP C + G CSH+CL++ +
Sbjct: 1490 NTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHN 1549
Query: 316 EPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDI-VLQVDDIRH 374
CACP ++L + +TC ++ LL ARR+++R + +D P F I V DI
Sbjct: 1550 RS-AACACPHLMKLSSDKKTCYE-MKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDD 1607
Query: 375 AIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
ID+D E +YWTD + + I+RA+++G+G +T+++ +I G+AVDWV+RNLYW
Sbjct: 1608 VTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWIS 1667
Query: 435 TGTD--RIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQ 492
+ D +I V RL+G S K + +D+P+ +A HPV G +YWTD I AN+DG
Sbjct: 1668 SEFDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTD---GNTINMANMDGS 1723
Query: 493 ERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL--LEDKLPHIFG 550
++L + P GL++D E KLYW + I N+DG + ++++L
Sbjct: 1724 NSKILFQ-NQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATA 1782
Query: 551 FTLLGDFIYWTDWQRRSIERVHKVKASRDVII-DQLPDLMGLKAVNVAKVVGTNPCADRN 609
T++ ++W D + K I+ ++ ++ +K + G+N C N
Sbjct: 1783 LTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNN 1842
Query: 610 GGCSHLCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNN-DV 667
GGCS LC T TR C C +G L + +C E+FL+++ I I LE ++ D
Sbjct: 1843 GGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDA 1902
Query: 668 AIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDW 727
+P++G A +DF N+ IYWTD+ ISRA + + E ++ GL EG+AVDW
Sbjct: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVDW 1962
Query: 728 MGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIV 787
+ N+YW D G N IEVARL+G FR V++ + LD PRS+A+ P KG ++WTEWG P I
Sbjct: 1963 IAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIG 2022
Query: 788 RAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNML--GQERVVIADD 844
+A +DG+ + LV + N ++IDY + +LYW D T+ IE ++ G +V++
Sbjct: 2023 KARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSGS 2082
Query: 845 LPHPFGLTQYSDYIYWTDWNLH---SIERADKTSGRNRTLIQGHLDF-VMDILVFHSSRQ 900
F + + YIYW+D H S+ R K ++ L + ++ +F+ R+
Sbjct: 2083 NVDMFSVAVFGAYIYWSD-RAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVRE 2141
Query: 901 DGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRM 959
G N C +NG C QLCL R C CA Y L C +LL+S ++ + +
Sbjct: 2142 KGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRHEGYLLYSGRTILKSI 2200
Query: 960 -IPDDQHSPDLILPLHGLRNVK-----AIDYDPLDK---FIYWVDGR-QNIKRAKDDGTQ 1009
+ D+ + I P R K A DY+ K I++ D NI+ KD+
Sbjct: 2201 HLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWED 2260
Query: 1010 PFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMG------VVLR 1063
V+ + G L+ TL+WT T++I H + G V+
Sbjct: 2261 RQVIVE-NVG-----SVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITM 2314
Query: 1064 GDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTL 1123
+ D P + ++ + +++TN ++ I R+ L G +V+ +T ++ P L +D
Sbjct: 2315 SEDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRA 2374
Query: 1124 GKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKT 1183
KL++ D L +IE C+ G+ R + + L L + +++W D ++ I R K
Sbjct: 2375 EKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKY 2434
Query: 1184 TGDKRTRIQGRVAHL-TGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPV 1242
TG ++ + H GI AV PCA NGGC +C+ +G CSC
Sbjct: 2435 TGGDTKILRSDIPHQPMGIIAVAN-DTNSCELSPCALLNGGCHDLCLLTPNGRVNCSCRG 2493
Query: 1243 HLVLLQNLLTCGEPPTCSP-DQFACATGEIDCIPGAWRCDGFPECDDQSDEE--GCP--V 1297
+LL++ + +C+ +F C GE CI CDG P C D+SDE+ C
Sbjct: 2494 DRILLEDNRCVTKNSSCNAYSEFECGNGE--CIDYQLTCDGIPHCKDKSDEKLLYCENRS 2551
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCD 1356
C PC +C+ CDGE DC D SDE DC + C +FRCA G C+ +C+
Sbjct: 2552 CRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCN 2611
Query: 1357 SFPDCIDGSDELMCEIT 1373
DC D SDE C T
Sbjct: 2612 QNIDCADASDEKNCNNT 2628
Score = 498 bits (1283), Expect = e-140
Identities = 325/952 (34%), Positives = 485/952 (50%), Gaps = 56/952 (5%)
Query: 21 ALCGCPAPAAASP----------LLLFANRRDVRLVDAGGVKLE--STIVVSGLEDAAAV 68
A C CP S LL+A R ++R VD + V ++D +
Sbjct: 1552 AACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVI 1611
Query: 69 DFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSE 128
DF S+ +YWTD+ + IK+ ++N TG ++ V+ + S GLA DWV + LYW SE
Sbjct: 1612 DFDASEERLYWTDIKTQTIKRAFINGTG--LETVISRDIQSIRGLAVDWVSRNLYWISSE 1669
Query: 129 TN--RIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTR 186
+ +I VA L+G S K +D+P+ +A P G +YWTD G T I A MDGS
Sbjct: 1670 FDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTD-GNT--INMANMDGSNS 1725
Query: 187 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKV--VEGSLTHPFALT 244
KI+ + P GL+ID E KLYW + I+R NLDG + + ++ LT ALT
Sbjct: 1726 KILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALT 1784
Query: 245 LSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNG 304
+ L+W D + C+KR G + + + ++V +E Q ++ C+ +NG
Sbjct: 1785 IMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNS-CQLNNG 1843
Query: 305 GCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTD 364
GCS LCL + SE TC C G LQ N +C+ G E L+ + +R I L+ D D
Sbjct: 1844 GCSQLCLPT-SETTRTCMCTVGYYLQKNRMSCQ-GIESFLMYSVHEGIRGIPLEPSDKMD 1901
Query: 365 IVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVD 424
++ + A+ ID+ +YWTD I RA D + + ++ + +GIAVD
Sbjct: 1902 ALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDIITNGLGRVEGIAVD 1961
Query: 425 WVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKI 484
W+A N+YWTD G + IEV RLNG+ R +++S+ LD+PR+IA+HP GL++WT+WG+ P I
Sbjct: 1962 WIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCI 2021
Query: 485 ECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVD-GTKRRTLLED 543
A LDG E+ VLV+ + WPNG+++D +E KLYW DA+TDKIE I+++ G R +L
Sbjct: 2022 GKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSG 2081
Query: 544 KLPHIFGFTLLGDFIYWTD--WQRRSIERVHKVKASRDVII--DQLPDLMGLKAVNVAKV 599
+F + G +IYW+D S+ R HK A+ + + +L +K N +
Sbjct: 2082 SNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRVRE 2141
Query: 600 VGTNPCADRNGGCSHLCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRI 658
GTN CA NGGC LC + ++ R C C G L D TC+ E +L+++ R + I
Sbjct: 2142 KGTNVCARDNGGCKQLCLYRGNSRRTCACAHGY-LAEDGVTCLRHEGYLLYSGRTILKSI 2200
Query: 659 SL--ETNNNDVAIPLTG---VKEASALDFDVS-----NNHIYWTDVSLKTISRAFMNGSS 708
L ETN N P K AL FD + N I+++D I N
Sbjct: 2201 HLSDETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWED 2260
Query: 709 VEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLD----GQF--RQVLVWRDLDN 762
+ +VE + EG+A LYW + T+ I +D G F V+ + D+
Sbjct: 2261 RQVIVE-NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDH 2319
Query: 763 PRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYW 820
P LALD + ++WT W + P I+R+ + G N +V + N LTIDY ++LY+
Sbjct: 2320 PHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYF 2379
Query: 821 TDLDTNMIESSNMLGQERVVIADDLPHPF-GLTQYSDYIYWTDWNLHSIERADKTSGRNR 879
+D IE G +R VI P F L Y +YI+W+DW +I R++K +G +
Sbjct: 2380 SDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDT 2439
Query: 880 TLIQGHLDF--VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGH-RCGC 928
+++ + + I V + + L+ C NG C LCL P G C C
Sbjct: 2440 KILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVNCSC 2491
Score = 495 bits (1275), Expect = e-139
Identities = 314/1024 (30%), Positives = 495/1024 (48%), Gaps = 86/1024 (8%)
Query: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-------------------- 338
C +NGGCS+ C + P C+CP G+QL + +TC+
Sbjct: 1176 CSLNNGGCSNHCSVVPGRGI-VCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHT 1234
Query: 339 ----------------------GAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAI 376
E ++ + R ++RRI L D++ L V +R+ I
Sbjct: 1235 VKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYS---LLVPGLRNTI 1291
Query: 377 AIDYDPLEGYVYWTDDEVRAIRRAYLDGSGA----QTLVNTEINDPDGIAVDWVARNLYW 432
A+D+ + +YWTD I R L SG + +V + P+G+ VDW+A N+YW
Sbjct: 1292 ALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYW 1351
Query: 433 TDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGEN-PKIECANLDG 491
D+ D+IEV +L+G+ R L++ ++ PRAIAL P G+++WTDW N P+IE A++ G
Sbjct: 1352 IDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSG 1411
Query: 492 QERRVLVN--ASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLL--EDKLPH 547
R+ + + WPNGL +D E ++ W DA++D I DGT ++ + L H
Sbjct: 1412 AGRKTIYKDMKTGAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSH 1471
Query: 548 IFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQL-PDLMGLKAVNVAK-VVGTNPC 605
F +L G +YWTDW+ ++ + +K +I + L+ + ++ NPC
Sbjct: 1472 PFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPC 1531
Query: 606 A--DRNGGCSHLCFFTPH-ATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLET 662
A D G CSH+C + + C CP ++L SD KTC + FL++ R+ I + ++
Sbjct: 1532 AANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDN 1591
Query: 663 N--NNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYP 720
N A + + + + +DFD S +YWTD+ +TI RAF+NG+ +E V+ +
Sbjct: 1592 PYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFINGTGLETVISRDIQSI 1651
Query: 721 EGMAVDWMGKNLYW--ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWT 778
G+AVDW+ +NLYW ++ +I VARLDG + ++ +D P+ LA P +G +YWT
Sbjct: 1652 RGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII-HGIDKPQCLAAHPVRGKLYWT 1710
Query: 779 EWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 838
+ I A MDG+N L L+IDY + +LYW I N+ G
Sbjct: 1711 DGN---TINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNL 1767
Query: 839 VVI---ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVF 895
VI ++L LT ++W D NL + K GRN T+++ V+ + V+
Sbjct: 1768 EVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVY 1827
Query: 896 HSSRQDGLNDCMHNNGQCGQLCLAIPGGHR-CGCASHYTLDPSSRNCSPPTTFLLFSQKS 954
Q G N C NNG C QLCL R C C Y L + +C +FL++S
Sbjct: 1828 DKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHE 1887
Query: 955 AISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQPFVL 1013
I + + D ++P+ G ID+ + IYW D G I RAK D T +
Sbjct: 1888 GIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI 1947
Query: 1014 TSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIV 1073
+ G + +++D + ++WT N I V RL+G V++ D+PR+I
Sbjct: 1948 ITNGLG-----RVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIA 2002
Query: 1074 VNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADL 1133
V+ E+G L++T I +A LDG+E+ VL + G+ P + +D KL+W DA
Sbjct: 2003 VHPEKGLLFWTEWGQMPC-IGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDART 2061
Query: 1134 KRIESCDL-SGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQ--MIERVEKTTGDKR-T 1189
+IE DL +G NR + + V + + G ++YW DR + R K + T
Sbjct: 2062 DKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETIT 2121
Query: 1190 RIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQN 1249
G +L + V E + CARDNGGC +C+ +G+ C+C H L ++
Sbjct: 2122 MRTGLGVNLKEVKIFNRV--REKGTNVCARDNGGCKQLCLYRGNSRRTCAC-AHGYLAED 2178
Query: 1250 LLTC 1253
+TC
Sbjct: 2179 GVTC 2182
Score = 336 bits (862), Expect = 9e-92
Identities = 207/637 (32%), Positives = 325/637 (51%), Gaps = 26/637 (4%)
Query: 28 PAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEA- 86
P P+LL AN + + G K+ + V+G E +DF +++ + W + E +
Sbjct: 199 PTDRPPILLIANFETIEVFYLNGSKMATLSSVNGNE-IHTLDFIYNEDMICWIESRESSN 257
Query: 87 -IKQTYLNQTGAAVQNVVISGLVS---PDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
+K + + G I+ L S +A DW+ + LY+ D +RI V N NG+
Sbjct: 258 QLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVC 317
Query: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
L +L P+AIA+DP G +++TD+G ++ER MDG R I+DS P L +
Sbjct: 318 VTLIDLELHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALAL 377
Query: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG-SLTHPFALTLSGDTLYWTDWQTRSIH 261
DL + +YW D L ++ + G R V++G + H + +T+ D LY T+ +I
Sbjct: 378 DLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIV 437
Query: 262 ACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEED----NGGCSHLCLLSPSE 316
N R G L + + I++ + QP + CE D GGCSH+CLLS S
Sbjct: 438 RIN-RFNGTDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSY 496
Query: 317 PFYTCACPTGVQLQDNGRTCKAGAEEVLLL---ARRTDLRRISLDTPDFTDIVLQVDDIR 373
TC C TG L +GR+CK E+ L R +R + L+T + ++ ++++
Sbjct: 497 KTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLV 556
Query: 374 HAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWT 433
+ A+D+ Y+Y+ D I R +DG+ +T++ ++++ +GIAVDW+ NLYWT
Sbjct: 557 NPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWT 616
Query: 434 DTGTDR-IEVTRLN--GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENP------KI 484
+ G + I V RL SRK L+ ++ PR I + PV G MYWTDW E+ +I
Sbjct: 617 NDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRI 676
Query: 485 ECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDK 544
E A +DG R++ V + + WPNGL LD LYW DA D IE + ++GT R+ + +
Sbjct: 677 EKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGR 736
Query: 545 -LPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTN 603
L H FG + G++++WTD+ SI ++ + + ++ + P L GL+ + K G N
Sbjct: 737 ELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDN 796
Query: 604 PCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC 640
C NGGCS LC P C C L + TC
Sbjct: 797 MCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTC 833
Score = 317 bits (811), Expect = 8e-86
Identities = 208/677 (30%), Positives = 344/677 (50%), Gaps = 43/677 (6%)
Query: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEE-----VLLLARRTDLRRISLD 358
G CS C + YTC+C G +Q + R+CKA E +LL+A + L+
Sbjct: 163 GTCSQTCRNTHGS--YTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLN 220
Query: 359 TPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTD-----DEVRAIRRAYLDGSGAQTLVNT 413
+ + H + Y+ E + W + ++++ I+ G + +N
Sbjct: 221 GSKMATLSSVNGNEIHTLDFIYN--EDMICWIESRESSNQLKCIQITKAGGLTDEWTINI 278
Query: 414 --EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMG 471
++ +A+DW+ RNLY+ D DRI V NG+ L+ +L P+AIA+ P+ G
Sbjct: 279 LQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAG 338
Query: 472 LMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVIN 531
+++TD+G K+E ++DG R ++++ P LALDL +YW D D + V++
Sbjct: 339 KLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVD 398
Query: 532 VDGTKRRTLLEDK-LPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMG 590
G R T+++ + + H++G T+ D++Y T+ +I R+++ + + ++ + G
Sbjct: 399 YQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIKIENAWG 458
Query: 591 LKAV--NVAKVVGTNPCA----DRNGGCSHLCFF-TPHATR-CGCPIGLELLSDMKTCIV 642
++ V ++ C GGCSH+C + + TR C C G L SD ++C
Sbjct: 459 IRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKR 518
Query: 643 P--EAFLVF-TSRAAIHR-ISLETN-NNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLK 697
P E FL + R I R + L T ++ IP+ + ALDF N+IY+ D +
Sbjct: 519 PKNELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSF 578
Query: 698 TISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNR-IEVARLD--GQFRQV 754
I R ++G+ E +++ LD EG+AVDW+G NLYW + G + I VARL+ Q R+
Sbjct: 579 LIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKT 638
Query: 755 LVWRDLDNPRSLALDPTKGYIYWTEW------GGKPRIVRAFMDGTNCMTLV-DKVGRAN 807
L+ ++ +PR + +DP G++YWT+W RI +A+MDG N V K+ N
Sbjct: 639 LLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPN 698
Query: 808 DLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI--ADDLPHPFGLTQYSDYIYWTDWNL 865
LT+D+ LYW D + IE + G R ++ +L HPFGL+ + +Y++WTD+
Sbjct: 699 GLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMN 758
Query: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHR 925
SI + D + TL++ + + ++ +Q G N C NNG C LCLAIPGG
Sbjct: 759 GSIFQLDLITS-EVTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRV 817
Query: 926 CGCASHYTLDPSSRNCS 942
C CA + LD + C+
Sbjct: 818 CACADNQLLDENGTTCT 834
Score = 281 bits (718), Expect = 5e-75
Identities = 229/853 (26%), Positives = 380/853 (44%), Gaps = 105/853 (12%)
Query: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTC---IVPEAFLVFTSRAAIHRISLETNNND 666
G CS C T + C C G + D ++C I P A I + N
Sbjct: 163 GTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGS 222
Query: 667 VAIPLTGVK--EASALDFDVSNNHIYWTDV-----SLKTISRAFMNGSSVEHVVEFGLDY 719
L+ V E LDF + + I W + LK I G + E + +
Sbjct: 223 KMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSF 282
Query: 720 P--EGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYW 777
+ MA+DW+ +NLY+ D +RI V +G L+ +L NP+++A+DP G +++
Sbjct: 283 HNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFF 342
Query: 778 TEWGGKPRIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQ 836
T++G ++ R MDG N ++D K + L +D ++ +YW DL + + + G+
Sbjct: 343 TDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGK 402
Query: 837 ER--VVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRN-RTLIQGHLDFVMDIL 893
R V+ + H +G+T + DY+Y T+ + ++I R ++ +G + +LI+ ++ I
Sbjct: 403 NRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLIK--IENAWGIR 460
Query: 894 VFHSSRQDGLN------DCMHNNGQCGQLCLAIPG--GHRCGCASHYTLDPSSRNCSPPT 945
++ Q + D G C +CL C C + + L R+C P
Sbjct: 461 IYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCRTGFNLGSDGRSCKRPK 520
Query: 946 T--FLLFSQ--KSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-I 1000
FL + + + M + + + + ++P+ L N +A+D+ +IY+ D I
Sbjct: 521 NELFLFYGKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLI 580
Query: 1001 KRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEA-TNTINVHRL--SGEA 1057
R K DGT+ + ++ +++D L+WT + TINV RL + ++
Sbjct: 581 GRQKIDGTERETIL-----KDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQS 635
Query: 1058 MGVVLRGDRDKPRAIVVNAERGYLYFTNMQ-----DRAAKIERAALDGTEREVLFTTGLI 1112
+L G+ PR IVV+ G++Y+T+ + D +IE+A +DG R++ T+ ++
Sbjct: 636 RKTLLEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKML 695
Query: 1113 RPVALVVDNTLGKLFWVDADLKRIESCDLSGANR-LTLEDANIVQPLGLTILGKHLYWID 1171
P L +D L+W DA IE L+G +R + + P GL+ G +++W D
Sbjct: 696 WPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTD 755
Query: 1172 RQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAK 1231
I +++ T + T ++ L G+ + ++ + C +NGGCS +C+A
Sbjct: 756 YMNGSIFQLDLITSEV-TLLRHERPPLFGLQIYD--PRKQQGDNMCRVNNGGCSTLCLAI 812
Query: 1232 GDGTPRCSCPVHLVLLQNLLTC----GE--PPTCSPDQFACATGEIDCIPGAWRCDGFPE 1285
G C+C + +L +N TC GE P C +F C CI W+CDG +
Sbjct: 813 PGGRV-CACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRH--CIQARWKCDGDDD 869
Query: 1286 CDDQSDEE-------GCP--------------------------------------VCSA 1300
C D SDE+ CP C
Sbjct: 870 CLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQV 929
Query: 1301 AQFPCARGQCVDLRLRCDGEADCQDRSDE-ADCD-AICLP-NQFRCASGQCVLIKQQCDS 1357
QF C G+C+ CD E DC D++DE A C+ C P QF C SG+C+ K CDS
Sbjct: 930 DQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDS 989
Query: 1358 FPDCIDGSDELMC 1370
DC DGSDE+ C
Sbjct: 990 DDDCGDGSDEVGC 1002
Score = 237 bits (604), Expect = 8e-62
Identities = 146/471 (30%), Positives = 229/471 (48%), Gaps = 30/471 (6%)
Query: 913 CGQLCLAIPGGHRCGCASHYTLDPSSRN----CSPPTTFLLFSQKSAISRMIPDDQHSPD 968
C Q C+ G ++C C Y + P + N S FL+ + I ++ D +
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSN--- 3034
Query: 969 LILPLHGLRNVKAIDYDPLDKFIYWVDGRQ----NIKRAKDDGTQPFVLTSLSQGQNPDR 1024
L GL NV AID+D ++FIYW+D + I R +G+ V+ + +
Sbjct: 3035 YTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV------ 3088
Query: 1025 QPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFT 1084
P+ L++D + L+W+ I V +L+G +++ PR + ++ + GYLY+
Sbjct: 3089 -PNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWI 3147
Query: 1085 NMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGA 1144
+ + I R +DGT + V+ T + RP+AL +D +L+W AD IE ++ G+
Sbjct: 3148 DCCEYP-HIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYW--ADENHIEFSNMDGS 3204
Query: 1145 NRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAV 1204
+R + + +I + LT+ ++YW D + + + R KT+G R + +T I
Sbjct: 3205 HRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVY 3264
Query: 1205 EEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQF 1264
+ S H C +NGGCSH+C+ T C+CP + L + TC C+ QF
Sbjct: 3265 HSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTC--LSNCTASQF 3322
Query: 1265 ACATGEIDCIPGAWRCDGFPECDDQSDE-EGCPV--CSAAQFPCARGQCVDLRLRCDGEA 1321
C T + CIP W+CD +C D SDE + CP C +F C G C CDGE
Sbjct: 3323 RCKTDK--CIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGEN 3380
Query: 1322 DCQDRSDEADCDA-ICLPNQFRCASGQ-CVLIKQQCDSFPDCIDGSDELMC 1370
DC D SDE +CD +CL QF+C Q C+ + +C+ DC D DE C
Sbjct: 3381 DCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Score = 224 bits (572), Expect = 4e-58
Identities = 138/355 (38%), Positives = 188/355 (52%), Gaps = 18/355 (5%)
Query: 612 CSHLCFFTPHATRCGCPIGLELLSD----MKTCIVPEAFLVFTSRAAIHRISLETNNNDV 667
CS C T +C C G E+ D K+ E FL+ I +IS T+ ++
Sbjct: 2978 CSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKIS--TDGSNY 3035
Query: 668 AIPLTGVKEASALDFDVSNNHIYWTDVSLKT---ISRAFMNGSSVEHVVEFGLDYPEGMA 724
+ G+ A+DFD IYW D S I+R +NGS ++ V + P +A
Sbjct: 3036 TLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PNALA 3093
Query: 725 VDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKP 784
VDW+GKNLYW+DT IEV++L+G + +LV + L PR L+LDP GY+YW + P
Sbjct: 3094 VDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYP 3153
Query: 785 RIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIAD 843
I R MDGTN +++ K+ R LTIDY ++RLYW D N IE SNM G R + +
Sbjct: 3154 HIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWA--DENHIEFSNMDGSHRHKVPN 3211
Query: 844 -DLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDG 902
D+P LT + DYIYWTD S+ RA KTSG +R + + DI V+HS RQ
Sbjct: 3212 QDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPD 3271
Query: 903 LND--CMHNNGQCGQLCLAIPG-GHRCGCASHYTLDPSSRNCSPPTTFLLFSQKS 954
++ CM NNG C LCL PG H C C +++ L +R C T F K+
Sbjct: 3272 VSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKT 3326
Score = 223 bits (569), Expect = 9e-58
Identities = 122/317 (38%), Positives = 180/317 (56%), Gaps = 13/317 (4%)
Query: 24 GCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVS 83
GC + + P L+ A+ ++R + G T++ GL + A+DF + + +YW D S
Sbjct: 3006 GCKSLSDEEPFLILADHHEIRKISTDGSNY--TLLKQGLNNVIAIDFDYREEFIYWIDSS 3063
Query: 84 E---EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGT 140
I + LN G+ ++ V+ P+ LA DW+GK LYW+D+E IEV+ LNG
Sbjct: 3064 RPNGSRINRMCLN--GSDIK--VVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGL 3119
Query: 141 SRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGL 200
+L + L PR ++LDP GY+YW D E P I R GMDG+ + +++++ I P L
Sbjct: 3120 YPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMAL 3179
Query: 201 TIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSI 260
TID ++LYWAD + I +N+DGS R KV + ALTL D +YWTD +T+S+
Sbjct: 3180 TIDYVNRRLYWADE--NHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSL 3237
Query: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTR-CEEDNGGCSHLCLLSPSEPFY 319
+K +G R ++ + ++ DIQV RQP C +NGGCSHLCLL+P + +
Sbjct: 3238 SRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKT-H 3296
Query: 320 TCACPTGVQLQDNGRTC 336
TCACPT L + RTC
Sbjct: 3297 TCACPTNFYLAADNRTC 3313
Score = 206 bits (524), Expect = 1e-52
Identities = 123/351 (35%), Positives = 182/351 (51%), Gaps = 29/351 (8%)
Query: 306 CSHLCLLSPSEPFYTCACPTGVQLQ-DNGRTCKAGAEE--VLLLARRTDLRRISLDTPDF 362
CS C+ + Y C C G ++Q DN CK+ ++E L+LA ++R+IS D ++
Sbjct: 2978 CSQQCINTYGT--YKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNY 3035
Query: 363 TDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEV---RAIRRAYLDGSGAQTLVNTEINDPD 419
T L + + IAID+D E ++YW D I R L+GS + + NT + P+
Sbjct: 3036 T---LLKQGLNNVIAIDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAV--PN 3090
Query: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
+AVDW+ +NLYW+DT IEV++LNG ILVS+ L PR ++L P G +YW D
Sbjct: 3091 ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCC 3150
Query: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
E P I +DG + V++ + P L +D +LYW D + IE N+DG+ R
Sbjct: 3151 EYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNRRLYWAD--ENHIEFSNMDGSHRHK 3208
Query: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKV 599
+ +P + TL D+IYWTD + +S+ R HK + D+L + A+ +V
Sbjct: 3209 VPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAHKTSGA-----DRLSLIYSWHAITDIQV 3263
Query: 600 --------VGTNPCADRNGGCSHLCFFTPHATR-CGCPIGLELLSDMKTCI 641
V + C NGGCSHLC P T C CP L +D +TC+
Sbjct: 3264 YHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACPTNFYLAADNRTCL 3314
Score = 175 bits (443), Expect = 4e-43
Identities = 108/313 (34%), Positives = 149/313 (47%), Gaps = 40/313 (12%)
Query: 54 ESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGL 113
E I + L + A+DF +Y+ D + I + ++ G + ++ L + +G+
Sbjct: 547 EYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKID--GTERETILKDDLDNVEGI 604
Query: 114 ACDWVGKKLYWT-DSETNRIEVANLN--GTSRKVLFWQDLDQPRAIALDPAHGYMYWTDW 170
A DW+G LYWT D I VA L SRK L ++ PR I +DP +G+MYWTDW
Sbjct: 605 AVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVDPVNGWMYWTDW 664
Query: 171 GETP------RIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANL 224
E RIE+A MDG R+I V S + WPNGLT+D LYW DA I + L
Sbjct: 665 EEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFL 724
Query: 225 DGSFRQKVVEG-SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMD 283
+G+ R+ V G L HPF L+ G+ ++WTD+ SI + T +
Sbjct: 725 NGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITS--------------E 770
Query: 284 IQVLSQERQPFFHTR------------CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQD 331
+ +L ER P F + C +NGGCS LCL P CAC L +
Sbjct: 771 VTLLRHERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGR--VCACADNQLLDE 828
Query: 332 NGRTCKAGAEEVL 344
NG TC E L
Sbjct: 829 NGTTCTFNPGEAL 841
Score = 127 bits (319), Expect = 9e-29
Identities = 95/364 (26%), Positives = 163/364 (44%), Gaps = 21/364 (5%)
Query: 905 DCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCS---PPTTFLLFSQKSAISRMIP 961
D N+ +C Q+C +C C + LD +C+ P F++FS + I R+
Sbjct: 1216 DYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRI-- 1273
Query: 962 DDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAK--DDGTQPFVLTSLSQ 1018
D H D L + GLRN A+D+ +YW D I R K + G + +
Sbjct: 1274 -DLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEH 1332
Query: 1019 GQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAER 1078
G P L++D + ++W + I V +L G ++ G + PRAI ++
Sbjct: 1333 GL---ATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRAIALDPRY 1389
Query: 1079 GYLYFTNMQDRAAKIERAALDGTEREVLF---TTGLIRPVALVVDNTLGKLFWVDADLKR 1135
G L++T+ +IE A++ G R+ ++ TG P L VD+ ++ W DA
Sbjct: 1390 GILFWTDWDANFPRIESASMSGAGRKTIYKDMKTG-AWPNGLTVDHFEKRIVWTDARSDA 1448
Query: 1136 IESCDLSGANRLTLEDAN--IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQG 1193
I S G N + + + + P +++ G +YW D + + + K TG + IQ
Sbjct: 1449 IYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQK 1508
Query: 1194 RVAHLTGIHAVEEVSLEEFSAHPCARDN--GGCSHICIAKGDGTPRCSCPVHLVLLQNLL 1251
A + + S + + +PCA ++ G CSH+C+ + + C+CP + L +
Sbjct: 1509 TSAQPFDLQ-IYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACPHLMKLSSDKK 1567
Query: 1252 TCGE 1255
TC E
Sbjct: 1568 TCYE 1571
Score = 125 bits (315), Expect = 3e-28
Identities = 56/120 (46%), Positives = 68/120 (56%), Gaps = 4/120 (3%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
TC P +F C +CIP WRCD +C D SDEE C C+ F CA G CV R
Sbjct: 3475 TCGPHEFQCKNN--NCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
Query: 1316 RCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKP 1375
CDG+ DC D SDE +C+ C +QFRC++GQC+ K +CD DC G DE CE P
Sbjct: 3533 WCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP 3592
Score = 122 bits (306), Expect = 3e-27
Identities = 107/371 (28%), Positives = 160/371 (43%), Gaps = 40/371 (10%)
Query: 298 RCEEDN-----GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDL 352
+CE+ N G CSH C+ E Y C C Q ++N + ++VL +A TD+
Sbjct: 3841 QCEDLNECLVFGTCSHQCI--NVEGSYKCVCDQNFQERNNTCIAEGSEDQVLYIANDTDI 3898
Query: 353 RRISLDTP-DFTDIVLQVDDIRHAIAID----YDPLEGYVYWTDDEVRAIRRAYLDGSGA 407
+ P +++ Q+ I H I Y + ++ T I + G
Sbjct: 3899 --LGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFNPGGIFYKRIHGREK 3956
Query: 408 QT----LVNTEINDPDGIAVDWVARNLYWTDTGTDR---------------IEVTRLNGT 448
+ L+ E P IAVDWVA N+YWTD I V +LNG
Sbjct: 3957 RQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGP 4016
Query: 449 SRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGL 508
+ L++ EP AIA++P G+MYWT G++ IE A +DG RR+LV +L P GL
Sbjct: 4017 NCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGL 4076
Query: 509 ALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDK--LPHIFGFTLLGDFIYWTDWQRR 566
A+D ++YW D + I + DG+ + K L H + D+IY +
Sbjct: 4077 AVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKN 4135
Query: 567 SIERVHKV-KASRDVIIDQLPDLMGLKAVNVAKVVG-TNPCADRNGGCSHLCFFTPHATR 624
+ RV K S + + + G+ + K + NPC D C LC P
Sbjct: 4136 GVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDL--ACEFLCLLNPSGAT 4193
Query: 625 CGCPIGLELLS 635
C CP G L++
Sbjct: 4194 CVCPEGKYLIN 4204
Score = 120 bits (301), Expect = 1e-26
Identities = 54/119 (45%), Positives = 71/119 (59%), Gaps = 7/119 (5%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC----PVCSAAQFPCARGQCVDL 1313
+CS DQF C+ G+ CIP W+CDG +C DE+ C P CS+ ++ CA C+
Sbjct: 3552 SCSKDQFRCSNGQ--CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISA 3609
Query: 1314 RLRCDGEADCQDRSDEADCDAICLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMCE 1371
L+C+GE DC D SDE DC C +QFRC + C+ I+ CD DC+DGSDE CE
Sbjct: 3610 SLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCE 3668
Score = 112 bits (281), Expect = 2e-24
Identities = 215/922 (23%), Positives = 350/922 (37%), Gaps = 155/922 (16%)
Query: 522 AKTDKIEVINVDGTKRRTL--LEDKLPHIFGFTLLGDFIYWTDWQRRS--IERVHKVKA- 576
A + IEV ++G+K TL + H F D I W + + S ++ + KA
Sbjct: 209 ANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAG 268
Query: 577 --SRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELL 634
+ + I+ L ++ + + + D G +C + + C I LEL
Sbjct: 269 GLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVC--NSNGSVCVTLIDLELH 326
Query: 635 SDMKTCIVPEA----FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIY 690
+ + P A F + + A + R ++ N I + ++ +AL D+ N +Y
Sbjct: 327 NPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIID-SKTEQPAALALDLVNKLVY 385
Query: 691 WTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGT-NRIEVARLDG 749
W D+ L + G + H V G + LY ++ N + + R +G
Sbjct: 386 WVDLYLDYVGVVDYQGKN-RHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNG 444
Query: 750 QFRQVLV-----W-------RDLDNPRSLA--LDPTK-----GYIYWTEWGGKPRIVRAF 790
L+ W R RS A +DP +I K R R
Sbjct: 445 TDIHSLIKIENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRTCRCR 504
Query: 791 M------DGTNCMTLVDKVGRANDLTIDYADQR---LYWTDLDTNMIESSNMLGQERVVI 841
DG +C N+L + Y R + DL+T + + E ++
Sbjct: 505 TGFNLGSDGRSCKR------PKNELFLFYGKGRPGIVRGMDLNTKIAD-------EYMIP 551
Query: 842 ADDLPHPFGLTQYSD--YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSR 899
++L +P L +++ YIY+ D I R T+++ LD V I V
Sbjct: 552 IENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAV----- 606
Query: 900 QDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRM 959
D + NN ++T D + + ++R+
Sbjct: 607 -----DWIGNN-------------------LYWTNDGHRKTIN-------------VARL 629
Query: 960 IPDDQHSPDLILPLHG-LRNVKAIDYDPLDKFIYWVDGRQN--------IKRAKDDG--T 1008
Q L L G + + + I DP++ ++YW D ++ I++A DG
Sbjct: 630 EKASQSRKTL---LEGEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNR 686
Query: 1009 QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDK 1068
Q FV + + P+ L++D ++ TL+W + I L+G +V G R+
Sbjct: 687 QIFVTSKMLW-------PNGLTLDFHTNTLYWCDAYYDHIEKVFLNGTHRKIVYSG-REL 738
Query: 1069 PRAIVVNAERGYLYFTN-MQDRAAKIERAALDGT----EREVLFTTGLIRPVALVVDNTL 1123
++ Y+++T+ M +++ + T ER LF + P DN
Sbjct: 739 NHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRHERPPLFGLQIYDPRKQQGDN-- 796
Query: 1124 GKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL---GKHLYWIDRQQQMIERV 1180
+ V+ + G D ++ G T G+ L I + + +
Sbjct: 797 --MCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGEFRCK- 853
Query: 1181 EKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC-SHICIAKG---DGTP 1236
+ R + G L G +E S+ F+ H C D C ++ CI K DG
Sbjct: 854 NRHCIQARWKCDGDDDCLDGS---DEDSVNCFN-HSCPDDQFKCQNNRCIPKRWLCDGAN 909
Query: 1237 RCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC- 1295
C ++ TC TC DQF+C G CIP AW CD +C DQ+DE
Sbjct: 910 DCGSNED----ESNQTC-TARTCQVDQFSCGNGR--CIPRAWLCDREDDCGDQTDEMASC 962
Query: 1296 --PVCSA-AQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIK 1352
P C QF C G+C+ + CD + DC D SDE C C NQFRC+SG+C+
Sbjct: 963 EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGH 1022
Query: 1353 QQCDSFPDCIDGSDELMCEITK 1374
CD DC D SDE TK
Sbjct: 1023 WACDGDNDCGDFSDEAQINCTK 1044
Score = 106 bits (264), Expect = 2e-22
Identities = 78/276 (28%), Positives = 117/276 (42%), Gaps = 30/276 (10%)
Query: 71 QFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTD---- 126
QF+ G +++ K+ + + A ++ P +A DWV +YWTD
Sbjct: 3940 QFNPGGIFY--------KRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRM 3991
Query: 127 -----------SETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPR 175
S I V LNG + L +P AIA++P G MYWT G+
Sbjct: 3992 HWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGDHSH 4051
Query: 176 IERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG 235
IE A MDG+ R+I+V ++ P GL +D +++YWAD +LS I DGS V
Sbjct: 4052 IEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVSVSS 4111
Query: 236 --SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQP 293
L HP + + D +Y + K G + + + + + + +Q
Sbjct: 4112 KQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRYKQL 4170
Query: 294 FFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQL 329
C + C LCLL+PS TC CP G L
Sbjct: 4171 DLPNPCLD--LACEFLCLLNPSGA--TCVCPEGKYL 4202
Score = 97.1 bits (240), Expect = 1e-19
Identities = 55/151 (36%), Positives = 86/151 (56%), Gaps = 12/151 (7%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC----PVCS-AAQFPC-ARGQ 1309
P C+ ++F C + +C+P WRCDG +C+D SDE+GC +C +F C + G+
Sbjct: 1050 PAGCNGNEFQCHP-DGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGR 1108
Query: 1310 CVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQ--CDSFPDCIDGSD 1366
C++ CDG+ DC+D+SDE DCD+ +C P + CA+ V ++ + C+ DC DGSD
Sbjct: 1109 CINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSD 1168
Query: 1367 E-LMCEITKPPSDDSPAHSSAIGPVIGIILS 1396
E +C+ + H S + P GI+ S
Sbjct: 1169 EGYLCDECSLNNGGCSNHCSVV-PGRGIVCS 1198
Score = 91.3 bits (225), Expect = 7e-18
Identities = 68/229 (29%), Positives = 100/229 (43%), Gaps = 23/229 (10%)
Query: 720 PEGMAVDWMGKNLYWADTGTNR---------------IEVARLDGQFRQVLVWRDLDNPR 764
P +AVDW+ N+YW D I V +L+G L+ P
Sbjct: 3971 PRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPY 4030
Query: 765 SLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDL 823
++A++P +G +YWT G I A MDGT LV K + R L +DY +R+YW D
Sbjct: 4031 AIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADF 4090
Query: 824 DTNMIESSNMLGQERVVIADD---LPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRT 880
+ ++I S G VV L HP + + DYIY + + R K +
Sbjct: 4091 ELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAG-PKNGVFRVQKFGHGSVE 4149
Query: 881 LIQGHLDFVMDILVFHSSRQ-DGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
+ ++D +L+ H +Q D N C+ + C LCL P G C C
Sbjct: 4150 YLALNIDKTKGVLISHRYKQLDLPNPCL--DLACEFLCLLNPSGATCVC 4196
Score = 89.7 bits (221), Expect = 2e-17
Identities = 42/100 (42%), Positives = 53/100 (53%), Gaps = 5/100 (5%)
Query: 1273 CIPGAWRCDGFPECDDQSDEEGCPV-----CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
C+ W CDG +C D SDE CPV C F C G+C+ CDG+ DC+D
Sbjct: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGR 2711
Query: 1328 DEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
DE CD+ C NQF C++ +C+ CD DC DG DE
Sbjct: 2712 DEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDE 2751
Score = 88.2 bits (217), Expect = 6e-17
Identities = 58/142 (40%), Positives = 69/142 (48%), Gaps = 18/142 (12%)
Query: 1232 GDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSD 1291
GD + CPV QN C E + F+C +G CI W CDG +C+D D
Sbjct: 2666 GDYSDELKCPV-----QNKHKCEE------NYFSCPSGR--CILNTWICDGQKDCEDGRD 2712
Query: 1292 EEGCPV-CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEAD--CDAI-CLPNQFRC-ASG 1346
E C CS QF C+ +C+ CDGE DC D DE+D C AI C + F C S
Sbjct: 2713 EFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSCQGSR 2772
Query: 1347 QCVLIKQQCDSFPDCIDGSDEL 1368
CV CD DC DGSDEL
Sbjct: 2773 ACVPRHWLCDGERDCPDGSDEL 2794
Score = 84.7 bits (208), Expect = 6e-16
Identities = 48/133 (36%), Positives = 65/133 (48%), Gaps = 13/133 (9%)
Query: 1253 CGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE---GCPVCSAAQFPCARGQ 1309
C TC + F C CIP + CD +C D SDE G C +F CA G+
Sbjct: 2799 CAPNNTCDENAFMCHNKV--CIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGR 2856
Query: 1310 C-VDLRLRCDGEADCQDRSDEA-------DCDAICLPNQFRCASGQCVLIKQQCDSFPDC 1361
C ++ + +CDG+ DC D SDEA + C + F C +G+C+ CD+ DC
Sbjct: 2857 CLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDC 2916
Query: 1362 IDGSDELMCEITK 1374
DGSDE C I +
Sbjct: 2917 GDGSDERNCHINE 2929
Score = 82.0 bits (201), Expect = 4e-15
Identities = 49/119 (41%), Positives = 60/119 (50%), Gaps = 10/119 (8%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE---EGCP---VCSAAQFPCARGQCV 1311
TC+ D F+C G C+P W CDG +C D SDE GC C F C C+
Sbjct: 2760 TCAADMFSCQ-GSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCI 2818
Query: 1312 DLRLRCDGEADCQDRSDEA-DCD-AICLPNQFRCASGQCVLIKQ-QCDSFPDCIDGSDE 1367
+ CD + DC D SDE+ C C +F CA G+C+L Q QCD DC D SDE
Sbjct: 2819 PKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE 2877
Score = 81.6 bits (200), Expect = 5e-15
Identities = 53/168 (31%), Positives = 65/168 (38%), Gaps = 55/168 (32%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCARGQCVDLR 1314
C DQF C + CIP W CDG +C D SDEE C +C A +F C C
Sbjct: 3632 CKEDQFRCKN-KAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
Query: 1315 LRCDGEADCQDRSDEAD----------------------------CDAI----------- 1335
CDGE DC D SDEA C+ I
Sbjct: 3691 WVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH 3750
Query: 1336 -----------CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
C ++F C++ +C+ + QCD DC DGSDE C I
Sbjct: 3751 CGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRI 3798
Score = 75.1 bits (183), Expect = 5e-13
Identities = 76/314 (24%), Positives = 129/314 (41%), Gaps = 44/314 (14%)
Query: 1024 RQPHDLSIDIYSRTLFWTCEATN---------------TINVHRLSGEAMGVVLRGDRDK 1068
++P D+++D + ++WT + +INV +L+G +L +
Sbjct: 3969 KRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGE 4028
Query: 1069 PRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFW 1128
P AI VN +RG +Y+T + D + IE AA+DGT R +L L RP L VD +++W
Sbjct: 4029 PYAIAVNPKRGMMYWTVVGDHS-HIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYW 4087
Query: 1129 VDADLKRIESCDLSGANRLTLEDA--NIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGD 1186
D +L I S G+N + + ++ P + I ++Y + + RV+K
Sbjct: 4088 ADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNGVF-RVQKFGHG 4146
Query: 1187 KRTRIQGRVAHLTGI---HAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVH 1243
+ + G+ H +++ L +PC + C +C+ G C CP
Sbjct: 4147 SVEYLALNIDKTKGVLISHRYKQLDL----PNPCL--DLACEFLCLLNPSGA-TCVCPEG 4199
Query: 1244 LVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRC------DGFPECDDQSDEEGCPV 1297
L+ TC+ D + ++ C G RC D C E C V
Sbjct: 4200 KYLING--------TCNDDSLLDDSCKLTCENGG-RCILNEKGDLRCHCWPSYSGERCEV 4250
Query: 1298 CSAAQFPCARGQCV 1311
+ + G CV
Sbjct: 4251 NHCSNYCQNGGTCV 4264
Score = 57.4 bits (137), Expect = 1e-07
Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 15/133 (11%)
Query: 1244 LVLLQNLLTCG---EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGCP-- 1296
L+ + +LT G + C P +F C + C+ +W CDG P+C D SDE + CP
Sbjct: 14 LLPIARVLTVGADRDQQLCDPGEFLCHD-HVTCVSQSWLCDGDPDCPDDSDESLDTCPEE 72
Query: 1297 ---VCSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDE-ADCDAICLPNQFRCASGQCVLI 1351
C C +CV L C+G DC D DE C + Q +C ++
Sbjct: 73 VEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMV 132
Query: 1352 KQQCDSFPDCIDG 1364
+ + C DG
Sbjct: 133 RNSTRCY--CEDG 143
Score = 47.0 bits (110), Expect = 1e-04
Identities = 27/79 (34%), Positives = 37/79 (46%), Gaps = 8/79 (10%)
Query: 1297 VCSAAQFPCA-RGQCVDLRLRCDGEADCQDRSDEA------DCDAICLPNQFRC-ASGQC 1348
+C +F C CV CDG+ DC D SDE+ + + C N C + +C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
Query: 1349 VLIKQQCDSFPDCIDGSDE 1367
V + Q C+ DC DG DE
Sbjct: 91 VHLSQLCNGVLDCPDGYDE 109
Score = 40.4 bits (93), Expect = 0.014
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 1/102 (0%)
Query: 676 EASALDFDVSNNHIYWTDVSLKT-ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYW 734
E A+ + +YWT V + I A M+G+ +V+ L P G+AVD+ + +YW
Sbjct: 4028 EPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYW 4087
Query: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIY 776
AD + I DG V V +D + YIY
Sbjct: 4088 ADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY 4129
Score = 33.9 bits (76), Expect = 1.3
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 1210 EEFSAHPCARDNGGCSHIC-IAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCS 1260
E + C+ +NGGCS+ C + G G CSCP L L ++ TC CS
Sbjct: 1169 EGYLCDECSLNNGGCSNHCSVVPGRGIV-CSCPEGLQLNKDNKTCEIVDYCS 1219
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 680 bits (1755), Expect = 0.0
Identities = 464/1435 (32%), Positives = 720/1435 (50%), Gaps = 100/1435 (6%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAA---AVDFQFSKGAVYWTD 81
C A+ S LLL A++ + A V + + S +E+ + AVDF G ++W+D
Sbjct: 1428 CKVTASESLLLLVASQNKII---ADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
Query: 82 VSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTS 141
++ + N T V V S ++ + +A DWVG+ LYWTD IEV+ ++G+
Sbjct: 1485 ATQGKTWSAFQNGTDRRV--VFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSH 1542
Query: 142 RKVLFWQDLDQPRAIALDPAHG--YMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNG 199
R VL ++L PR +ALDP ++W+DWG PRIERA MDGS R +IV I+WP G
Sbjct: 1543 RTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCG 1602
Query: 200 LTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSL--THPFALTLSGDTLYWTDWQT 257
LTID + LY+ D+ L ++ + +G R++V+ L HP+ALTL D++YWTD T
Sbjct: 1603 LTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRAT 1662
Query: 258 RSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEP 317
R + NK GG + ++ + P+ I + +QP C CSHLCLLS P
Sbjct: 1663 RRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR--CSHLCLLSSQGP 1720
Query: 318 -FYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTP-DFTDIVLQVDDIRHA 375
FY+C CP+G L + C + L+ R+ + ISL+ D ++ + I++
Sbjct: 1721 HFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNG 1780
Query: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD-GIAVDWVARNLYWTD 434
+ +++D E Y+YW ++ I R DG+ + + P +A+DW++RNLY T+
Sbjct: 1781 LDVEFDDAEQYIYWVENP-GEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTN 1839
Query: 435 TGTDRIEVTRLNG--TSRKILVSED-----LDEPRAIALHPVMGLMYWTDWGEN----PK 483
T IEV L+G RK L++ D + P I + P G +YW+D G + K
Sbjct: 1840 PRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAK 1899
Query: 484 IECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLED 543
I AN+DG + L +L + LD++E KLYW IE NVDGT R L+
Sbjct: 1900 IASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH- 1958
Query: 544 KLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVII-DQLPDLMGLKAVNVAKVV-G 601
+L H +G + F+Y+TD Q IERV K + +++ D +P+L GL+ +
Sbjct: 1959 QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAES 2018
Query: 602 TNPCADRNGGCSHLCFFTPHAT-RCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISL 660
+N C++ C +C P C C G +L D ++C +F+V + +AI SL
Sbjct: 2019 SNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSL 2078
Query: 661 E-TNNNDVAIPLTGV-KEASALDFDVSNNHIYWTDVSL-----KTISRAFMNGSSVEHVV 713
E +++++ +P+ G + A +D DVS+ IYW D S I R +GSS+ ++V
Sbjct: 2079 ELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIV 2138
Query: 714 EFGL--DYPEGMAVDWMGKNLYWADTGTNR--IEVARLDGQFRQVLVWRDLDNPRSLALD 769
G+ + G+AVDW+ NLY+ + + IEV R++ +R+VL+ +D PR + +D
Sbjct: 2139 THGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVD 2198
Query: 770 PTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMI 828
P Y++W ++G +P+I R+F+D TN LV + + L +D +D +YW D ++I
Sbjct: 2199 PKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDII 2258
Query: 829 ESSNMLGQERVVI--ADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNR--TLIQG 884
+ G+ VI P P+G+T + + I W D NL I +A K T+I+
Sbjct: 2259 ARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRD 2318
Query: 885 HLDFVMDILVF------HSSRQDGLNDCMHNNGQCGQLCLAIPGGH--RCGCASHYTLDP 936
+++++ D+ +F S + N C+ NNG C LC A+PG H +C CA TL
Sbjct: 2319 NINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCA-FGTLQS 2377
Query: 937 SSRNCSPPT-TFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD 995
+NC+ T FL+F+ +++ + D ++ ++ R V ++DYD + IY+
Sbjct: 2378 DGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFT- 2436
Query: 996 GRQNIKRAKDDGTQPFVLTSLSQGQNPDR-------QPHDLSIDIYSRTLFWTCEATNTI 1048
QN+ G +LS G + ++ D +R ++++ I
Sbjct: 2437 --QNLA----SGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMI 2490
Query: 1049 NVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFT 1108
N G V+ R KPRAIV++ +GYLY+ + D AKIERA L G R +
Sbjct: 2491 NSMAEDGSNRTVIAR--VPKPRAIVLDPCQGYLYWADW-DTHAKIERATLGGNFRVPIVN 2547
Query: 1109 TGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLY 1168
+ L+ P L +D L+WVDA L+RIE L+G +R + +A V GLT+ G+++Y
Sbjct: 2548 SSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA-AVHAFGLTLYGQYIY 2606
Query: 1169 WIDRQQQMIERVEKTTGDKRTRI-QGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHI 1227
W D Q I R K G + + ++ GI+ V + ++ + +PC + NGGCSHI
Sbjct: 2607 WTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCN-NPCEQFNGGCSHI 2665
Query: 1228 CIAKGDGTPRCSCP--VHLVLLQNLLTC--GEPPTCSPDQFACATGEIDCIPGAWRCDGF 1283
C A G C CP + L N C C F C+ G CI W+CD
Sbjct: 2666 C-APGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGR--CISEEWKCDND 2722
Query: 1284 PECDDQSDEE----GCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEA-----DCDA 1334
+C D SDE CS F CA G+CV RCD DC D SDEA DC+A
Sbjct: 2723 NDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNA 2782
Query: 1335 ICLPNQFRCASGQCVLIKQQCDSFPDCIDG--SDELMCEITKPPSDDSPAHSSAI 1387
+F C + +C+ + C+ +C D SDE C S + H+S I
Sbjct: 2783 ---TTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNI 2834
Score = 488 bits (1256), Expect = e-137
Identities = 310/982 (31%), Positives = 514/982 (52%), Gaps = 54/982 (5%)
Query: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLD-TPDF 362
G CS C + C+C TG L+ +GRTCK A E LLL + + I+ T
Sbjct: 1398 GSCSQHCYNMRGS--FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQV 1455
Query: 363 TDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIA 422
+I V++ + +A+D+D + G ++W+D A+ +G+ + + ++ I + IA
Sbjct: 1456 HNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIA 1515
Query: 423 VDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMG--LMYWTDWGE 480
+DWV RNLYWTD + IEV++++G+ R +L+S++L PR +AL P M L++W+DWG
Sbjct: 1516 IDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGH 1575
Query: 481 NPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTL 540
+P+IE A++DG R V+V + WP GL +D LY+ D+ D ++ + +G RR +
Sbjct: 1576 HPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQV 1635
Query: 541 LEDKL--PHIFGFTLLGDFIYWTDWQRRSIERVHKVK-ASRDVIIDQLPDLMGLKAVNVA 597
+ L H + TL D +YWTD R + R +K ++ V++ + +G+ AV+ +
Sbjct: 1636 IASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPS 1695
Query: 598 KVVGT-NPCADRNGGCSHLCFFT---PHATRCGCPIGLELLSDMKTCI-VPEAFLVFTSR 652
K + NPCA CSHLC + PH C CP G L D+ C+ + FL+ +
Sbjct: 1696 KQPNSVNPCAFSR--CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQ 1753
Query: 653 AAIHRISL--ETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVE 710
I ISL E +ND +P+ G++ ++FD + +IYW + + I R +G++
Sbjct: 1754 HIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRT 1812
Query: 711 HVVEFGLDYPE-GMAVDWMGKNLYWADTGTNRIEVARLDG--QFRQVLVWRD-----LDN 762
+ P +A+DW+ +NLY + T IEV L G ++R+ L+ D +
Sbjct: 1813 VFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGF 1872
Query: 763 PRSLALDPTKGYIYWTEWG---GKP-RIVRAFMDGTNCMTL-VDKVGRANDLTIDYADQR 817
P + +DP +G +YW++ G G P +I A MDGT+ TL + +T+D +Q+
Sbjct: 1873 PIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQK 1932
Query: 818 LYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGR 877
LYW +IE N+ G +R+++ L HP+G+ + ++Y+TD IER DK +G
Sbjct: 1933 LYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGA 1992
Query: 878 NRTLIQGHLDFVMDILVFH-SSRQDGLNDCMHNNGQCGQLCLAIPGG-HRCGCASHYTLD 935
N+ +++ ++ + + V+H + + N C +N C Q+CL +PGG C CA+ + L+
Sbjct: 1993 NKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLN 2052
Query: 936 PSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGL-RNVKAIDYDPLDKFIYWV 994
P +R+CSP +F++ S SAI + + ++P+ G RN +D D FIYW
Sbjct: 2053 PDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWC 2112
Query: 995 DGRQN------IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWT--CEATN 1046
D + I+R K DG+ + + G+N R +++D + L++T +
Sbjct: 2113 DFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVR---GIAVDWVAGNLYFTNAFVSET 2169
Query: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
I V R++ V+L+ D PR IVV+ + YL++ + R KIER+ LD T R VL
Sbjct: 2170 LIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQR-PKIERSFLDCTNRTVL 2228
Query: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLE-DANIVQPLGLTILGK 1165
+ G++ P L VD + G ++WVD L I ++G N + + P G+T+
Sbjct: 2229 VSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFEN 2288
Query: 1166 HLYWIDRQQQMIERVEK--TTGDKRTRIQGRVAHLTGI----HAVEEVSLEEFSAHPCAR 1219
+ W+DR + I + K + T I+ + L + V+ S E + +PC
Sbjct: 2289 SIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLE 2348
Query: 1220 DNGGCSHICIA-KGDGTPRCSC 1240
+NGGCSH+C A G TP+C C
Sbjct: 2349 NNGGCSHLCFALPGLHTPKCDC 2370
Score = 386 bits (992), Expect = e-107
Identities = 258/823 (31%), Positives = 399/823 (48%), Gaps = 68/823 (8%)
Query: 610 GGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAF----LVFTSR-----AAIH---- 656
G C C P C C G +L + C ++F ++F++ IH
Sbjct: 356 GICDQKCESRPGRHLCHCEEGY-ILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSF 414
Query: 657 RISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFG 716
RI +E+ N VA+ + F ++WTD + +NG +++ V+
Sbjct: 415 RILVESQNRGVAVGVA---------FHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVS 465
Query: 717 LDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIY 776
++ PE +AVDW+ +Y +T NRI++ LDG +R L+ +L +PR +A+DPT GY++
Sbjct: 466 VETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLF 525
Query: 777 WTEW---GGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSN 832
+++W G+P++ RAFMDG+N LV K+G +T+D +R+YW D + IE+
Sbjct: 526 FSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVT 585
Query: 833 MLGQERVVIADD---LPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFV 889
G +R + +PHPFG++ + +++TDW ++ +A+K + N +
Sbjct: 586 YDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRP 645
Query: 890 MDILVFHSSRQD-GLNDCMHNNGQCGQLCLAIPG------GHRCGCASHYTLDPSSRNCS 942
+ V+HS RQ N C NNG C Q+C+ G RC C + LD R+C
Sbjct: 646 YGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI 705
Query: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRN-VKAIDYDPLDKFIYWVD-GRQNI 1000
FL+FS + AI + D+++P+ G + ID+D D I++ D + I
Sbjct: 706 AVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMI 765
Query: 1001 KRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGV 1060
+ K DGT +L + N L+ D S+ L+WT +I+V RL+ +
Sbjct: 766 FKQKIDGTGREILAA-----NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRT 820
Query: 1061 VLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVD 1120
V++ + PR++VV+ GYL+FT+ R AKI RA DG+ + T L P L +D
Sbjct: 821 VVQ-YLNNPRSVVVHPFAGYLFFTDW-FRPAKIMRAWSDGSHLLPVINTTLGWPNGLAID 878
Query: 1121 NTLGKLFWVDADLKRIESCDLSGANRLTL-EDANIVQPLGLTILGKHLYWIDRQQQMIER 1179
+L+WVDA +IE G +R L + P GL I G+HL++ D + I R
Sbjct: 879 WAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIR 938
Query: 1180 VEKTTGDKRTRIQGRVAHLTGIHAVE-EVSLEEFSAHPCARDNGGCSHICIAKGDGTPRC 1238
V K G + T I+ +A++ + + + + + + NG CSH C + C
Sbjct: 939 VRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVC 998
Query: 1239 SCPVHLVLLQNLLTC-----GEPPT--CSPDQFACATGEIDCIPGAWRCDGFPECDDQSD 1291
CP + L N LTC EPPT C F C G C+P + CDG +C D SD
Sbjct: 999 GCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGR--CVPNYYLCDGVDDCHDNSD 1056
Query: 1292 EEGC----PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC----DAICLPNQFRC 1343
E+ C CS++ F C G+C+ RCD DC D SDE +C A CL Q+ C
Sbjct: 1057 EQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC 1116
Query: 1344 ASGQCVLIKQQCDSFPDCIDGSDELMC---EITKPPSDDSPAH 1383
+ QC+ CD+ DC DGSDE C E +P + P H
Sbjct: 1117 DNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNH 1159
Score = 374 bits (960), Expect = e-103
Identities = 208/623 (33%), Positives = 335/623 (53%), Gaps = 22/623 (3%)
Query: 35 LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQ 94
++F+N RD+ + D G + A V F + V+WTD + + +N
Sbjct: 396 IIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDIN- 454
Query: 95 TGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPR 154
G +Q V+ + +P+ LA DWV K+Y +++ NRI++ NL+G+ R L ++L PR
Sbjct: 455 -GLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPR 513
Query: 155 AIALDPAHGYMYWTDW----GETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLY 210
IA+DP GY++++DW GE P++ERA MDGS RK +V + + WP G+T+D+ +++Y
Sbjct: 514 GIAVDPTVGYLFFSDWESLSGE-PKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVY 572
Query: 211 WADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKRTG 268
W D++ +I DG R+ VV G + HPF ++L +++TDW ++ NK T
Sbjct: 573 WVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTE 632
Query: 269 GKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPF----YTCACP 324
+ A P + V RQP+ C+++NGGC +C+LS + C C
Sbjct: 633 TNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCT 692
Query: 325 TGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVD-DIRHAIAIDYDPL 383
G QL + R C A + L+ + + +R I D+++ V + + ID+D
Sbjct: 693 FGFQLDTDERHCIA-VQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQ 751
Query: 384 EGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVT 443
+ ++++D I + +DG+G + L + + + +A DW+++NLYWTD+ I V
Sbjct: 752 DSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVM 811
Query: 444 RLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLG 503
RL +R+ +V + L+ PR++ +HP G +++TDW KI A DG ++N +LG
Sbjct: 812 RLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLG 870
Query: 504 WPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE-DKLPHIFGFTLLGDFIYWTD 562
WPNGLA+D +LYW DA DKIE DG RR L +++ H FG + G+ +++TD
Sbjct: 871 WPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTD 930
Query: 563 WQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVVGTNPC---ADRNGGCSHLCFF 618
W+ +I RV K VI + ++ LK+ +V G+N C NG CSH CF
Sbjct: 931 WRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFP 990
Query: 619 TPHATR-CGCPIGLELLSDMKTC 640
P+ R CGCP G+ L S+ TC
Sbjct: 991 VPNFQRVCGCPYGMRLASNHLTC 1013
Score = 305 bits (780), Expect = 3e-82
Identities = 221/755 (29%), Positives = 359/755 (47%), Gaps = 91/755 (12%)
Query: 572 HKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGL 631
H + + V+ D + D + + + N C+D NGGC+H C P +C CP+G
Sbjct: 1322 HNICVNLSVVCDGIFDCPN--GTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGF 1379
Query: 632 ELLSDMKTC------------------------------------------IVPEAFLVF 649
L +D KTC E+ L+
Sbjct: 1380 LLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLL 1439
Query: 650 TSRAAIHRISLETNNNDVAIPLTGVKEAS---ALDFDVSNNHIYWTDVSLKTISRAFMNG 706
A+ ++I ++ + V + V+ S A+DFD + I+W+D + AF NG
Sbjct: 1440 V--ASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNG 1497
Query: 707 SSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSL 766
+ V + + E +A+DW+G+NLYW D IEV+++DG R VL+ ++L NPR L
Sbjct: 1498 TDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGL 1557
Query: 767 ALDP--TKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQRLYWTDL 823
ALDP + ++W++WG PRI RA MDG+ +V DK+ LTIDY ++ LY+ D
Sbjct: 1558 ALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDS 1617
Query: 824 DTNMIESSNMLG-QERVVIADDL--PHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRT 880
+ ++ + G R VIA DL HP+ LT + D +YWTD + RA+K G N++
Sbjct: 1618 YLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQS 1677
Query: 881 LIQGHLDFVMDILVFHSSRQ-DGLNDCMHNNGQCGQLCLAIPGG---HRCGCASHYTLDP 936
++ ++ + + I+ H S+Q + +N C + +C LCL G + C C S ++L P
Sbjct: 1678 VVMYNIQWPLGIVAVHPSKQPNSVNPCAFS--RCSHLCLLSSQGPHFYSCVCPSGWSLSP 1735
Query: 937 SSRNC-SPPTTFLLFSQKSAISRM-IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWV 994
NC FL+ ++ I + + + S D ++P+ G++N +++D +++IYWV
Sbjct: 1736 DLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWV 1795
Query: 995 DGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLS 1054
+ I R K DGT V S+S P +L++D SR L+ T T +I V L
Sbjct: 1796 ENPGEIHRVKTDGTNRTVFASISM-VGPSM---NLALDWISRNLYSTNPRTQSIEVLTLH 1851
Query: 1055 GE-------------AMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRA---AKIERAAL 1098
G+ A+GV P I V+ RG LY+++ + AKI A +
Sbjct: 1852 GDIRYRKTLIANDGTALGVGF------PIGITVDPARGKLYWSDQGTDSGVPAKIASANM 1905
Query: 1099 DGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPL 1158
DGT + LFT L + +D KL+W IE ++ G +R+ L + P
Sbjct: 1906 DGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVH-QLSHPW 1964
Query: 1159 GLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCA 1218
G+ + LY+ D Q ++IERV+K TG + ++ V +L G+ + E S++ C+
Sbjct: 1965 GIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAE-SSNGCS 2023
Query: 1219 RDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC 1253
+ C IC+ G C+C L + +C
Sbjct: 2024 NNMNACQQICLPVPGGLFSCACATGFKLNPDNRSC 2058
Score = 253 bits (647), Expect = 8e-67
Identities = 122/320 (38%), Positives = 186/320 (58%), Gaps = 13/320 (4%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C + P L+F+NR +R + G ++++ GL++ A+DF + +YW D
Sbjct: 3191 CRQNSNIEPYLIFSNRYYLRNLTIDGYFY--SLILEGLDNVVALDFDRVEKRLYWIDTQR 3248
Query: 85 EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKV 144
+ I++ +LN+T + ++ L + + LA DWV +KLYW D+ + + V++LNG R++
Sbjct: 3249 QVIERMFLNKTNK--ETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRM 3306
Query: 145 LFWQDLD--------QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYW 196
L +D PR +AL P +GY+YW DWG I R GMDG+ + +I+ + + W
Sbjct: 3307 LAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEW 3366
Query: 197 PNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQ 256
PNG+TID LYWADA L +I ++L+G R V +G+L HPFA+T+ DT+YWTDW
Sbjct: 3367 PNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWN 3426
Query: 257 TRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSE 316
TR++ NK G R+ +++ + P DI V RQP C +NGGCSHLCL+ P
Sbjct: 3427 TRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGG 3486
Query: 317 PFYTCACPTGVQ-LQDNGRT 335
+TC CP + LQ +G T
Sbjct: 3487 KGFTCECPDDFRTLQLSGST 3506
Score = 231 bits (589), Expect = 4e-60
Identities = 157/486 (32%), Positives = 233/486 (47%), Gaps = 34/486 (6%)
Query: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTT---FLLFSQKSAISRM 959
+++C C Q C + G + C CA Y +P + C + +L+FS + + R
Sbjct: 3153 IDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYL-RN 3211
Query: 960 IPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDG-RQNIKRAKDDGTQPFVLTSLSQ 1018
+ D + LIL GL NV A+D+D ++K +YW+D RQ I+R + T + +
Sbjct: 3212 LTIDGYFYSLIL--EGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIIN--- 3266
Query: 1019 GQNPDRQP--HDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRD--------K 1068
R P L++D SR L+W + + V L+G ++ + D
Sbjct: 3267 ----HRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDN 3322
Query: 1069 PRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFW 1128
PR + ++ + GYLY+ + RA I R +DGT + V+ +T L P + +D T L+W
Sbjct: 3323 PRGLALHPQYGYLYWADWGHRAY-IGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYW 3381
Query: 1129 VDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKR 1188
DA L IE DL G +R T+ D + P +TI +YW D + +E+ K G R
Sbjct: 3382 ADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNR 3441
Query: 1189 TRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTP-RCSCPVHLVLL 1247
+ IH V + ++PC +NGGCSH+C+ K G C CP L
Sbjct: 3442 QTLVNTTHRPFDIH-VYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTL 3500
Query: 1248 QNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEG-CP--VCSAAQFP 1304
Q + P CS QF CA E CIP W+CDG +C D SDE CP C QF
Sbjct: 3501 QLSGSTYCMPMCSSTQFLCANNE-KCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQ 3559
Query: 1305 CARGQCVDLRLRCDGEADCQDRSDEADC---DAICLPNQFRCASGQCVLIKQQCDSFPDC 1361
C+ G C + C+ +C D SDE + C N+++CA+ +C+ QCD+F DC
Sbjct: 3560 CSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDC 3619
Query: 1362 IDGSDE 1367
D SDE
Sbjct: 3620 EDNSDE 3625
Score = 217 bits (552), Expect = 8e-56
Identities = 109/324 (33%), Positives = 174/324 (53%), Gaps = 17/324 (5%)
Query: 319 YTCACPTGVQLQDNGRTCKAGA--EEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAI 376
Y C C G + +G+TC+ + E L+ + R LR +++D ++ I+ +D++ +
Sbjct: 3174 YICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNV---V 3230
Query: 377 AIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTG 436
A+D+D +E +YW D + + I R +L+ + +T++N + + +AVDWV+R LYW D
Sbjct: 3231 ALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDAR 3290
Query: 437 TDRIEVTRLNGTSRKILVSEDLD--------EPRAIALHPVMGLMYWTDWGENPKIECAN 488
D + V+ LNG R++L +D PR +ALHP G +YW DWG I
Sbjct: 3291 LDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVG 3350
Query: 489 LDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHI 548
+DG + V+++ L WPNG+ +D LYW DA IE +++G R T+ + LPH
Sbjct: 3351 MDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHP 3410
Query: 549 FGFTLLGDFIYWTDWQRRSIERVHKVKAS-RDVIIDQLPDLMGLKAVN-VAKVVGTNPCA 606
F T+ D IYWTDW R++E+ +K S R +++ + + + + +NPC
Sbjct: 3411 FAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCG 3470
Query: 607 DRNGGCSHLCFFTP--HATRCGCP 628
NGGCSHLC P C CP
Sbjct: 3471 TNNGGCSHLCLIKPGGKGFTCECP 3494
Score = 214 bits (544), Expect = 7e-55
Identities = 139/422 (32%), Positives = 198/422 (46%), Gaps = 65/422 (15%)
Query: 598 KVVGTNPCADRN-GGCSHLCFFTPHATRCGCPIGLELLSDMKTCI-------VP------ 643
K G N C D + GC H C T + C C G +L+SD +TC+ +P
Sbjct: 3107 KGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQK 3166
Query: 644 -------------------------------EAFLVFTSRAAIHRISLETNNNDVAIPLT 672
E +L+F++R + ++++ ++ L
Sbjct: 3167 CENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTID--GYFYSLILE 3224
Query: 673 GVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNL 732
G+ ALDFD +YW D + I R F+N ++ E ++ L E +AVDW+ + L
Sbjct: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKL 3284
Query: 733 YWADTGTNRIEVARLDGQFRQVLVWRDL--------DNPRSLALDPTKGYIYWTEWGGKP 784
YW D + + V+ L+G R++L + DNPR LAL P GY+YW +WG +
Sbjct: 3285 YWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRA 3344
Query: 785 RIVRAFMDGTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIAD 843
I R MDGTN ++ K+ N +TIDY + LYW D IE S++ G R + D
Sbjct: 3345 YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYD 3404
Query: 844 D-LPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDG 902
LPHPF +T + D IYWTDWN ++E+ +K G NR + DI V+H RQ
Sbjct: 3405 GALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPI 3464
Query: 903 L-NDCMHNNGQCGQLCLAIPG--GHRCGCASHY-TLDPS-SRNCSP---PTTFLLFSQKS 954
+ N C NNG C LCL PG G C C + TL S S C P T FL + +
Sbjct: 3465 VSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEK 3524
Query: 955 AI 956
I
Sbjct: 3525 CI 3526
Score = 200 bits (509), Expect = 8e-51
Identities = 128/377 (33%), Positives = 195/377 (51%), Gaps = 34/377 (9%)
Query: 290 ERQPFFHTRCEEDN-----GGCSHLCLLSPSEPFYTCACPTGVQLQDN--GRTCKA-GAE 341
E F T C + N G C C + Y C C G + G+ C A G+
Sbjct: 3996 ETNVFDRTSCLDINECEQFGTCPQHCRNTKGS--YECVCADGFTSMSDRPGKRCAAEGSS 4053
Query: 342 EVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLE---GYVYWT----DDEV 394
+LLL +R+ +L + F++ LQ ++ A+ D+DP + VY+T
Sbjct: 4054 PLLLLPDNVRIRKYNLSSERFSEY-LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRF 4112
Query: 395 RAIRRAYLDG--SGAQTLVNTE------INDPDGIAVDWVARNLYWTDTGTDRIEVTRLN 446
AI+RAY+ SG LV + PDGIAVDWV R++YW+D RIEV +L+
Sbjct: 4113 GAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLD 4172
Query: 447 GTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPN 506
G RK L+S DLD+P AIA++P +GLM+WTDWG+ PKIE A ++G++R +LV LGWP
Sbjct: 4173 GRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPT 4232
Query: 507 GLALD-LQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQR 565
GL++D L ++YW D K D IE I DGT RR + ++ + + + + D +YW ++
Sbjct: 4233 GLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAM-NPYSLDIFEDQLYWISKEK 4291
Query: 566 RSIERVHKV---KASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHA 622
+ + +K K + ++++ P L ++ + + + P + CSHLC P
Sbjct: 4292 GEVWKQNKFGQGKKEKTLVVN--PWLTQVRIFHQLRYNKSVPNLCKQ-ICSHLCLLRPGG 4348
Query: 623 TRCGCPIGLELLSDMKT 639
C CP G + T
Sbjct: 4349 YSCACPQGSSFIEGSTT 4365
Score = 178 bits (452), Expect = 3e-44
Identities = 116/333 (34%), Positives = 169/333 (50%), Gaps = 26/333 (7%)
Query: 27 APAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSK-----GAVYWTD 81
A +SPLLL + +R + + + E AVD+ + VY+T
Sbjct: 4048 AAEGSSPLLLLPDNVRIRKYNLSSERFSEYL--QDEEYIQAVDYDWDPKDIGLSVVYYTV 4105
Query: 82 VSEE----AIKQTYLNQTGAAVQNVV------ISGLVSPDGLACDWVGKKLYWTDSETNR 131
E AIK+ Y+ + N+V + ++ PDG+A DWVG+ +YW+D + R
Sbjct: 4106 RGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKR 4165
Query: 132 IEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVD 191
IEVA L+G RK L DLDQP AIA++P G M+WTDWG+ P+IE A M+G R I+V
Sbjct: 4166 IEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVF 4225
Query: 192 SDIYWPNGLTID-LEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTL 250
D+ WP GL+ID L ++YW+D K I DG+ R +V+ +P++L + D L
Sbjct: 4226 EDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDR-RVIAKEAMNPYSLDIFEDQL 4284
Query: 251 YWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQER-QPFFHTRCEEDNGGCSHL 309
YW + + NK GK+++ L +++ Q R C++ CSHL
Sbjct: 4285 YWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHL 4341
Query: 310 CLLSPSEPFYTCACPTGVQLQDNGRT-CKAGAE 341
CLL P Y+CACP G + T C A E
Sbjct: 4342 CLLRPGG--YSCACPQGSSFIEGSTTECDAAIE 4372
Score = 155 bits (391), Expect = 4e-37
Identities = 87/274 (31%), Positives = 143/274 (52%), Gaps = 9/274 (3%)
Query: 68 VDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDS 127
+DF ++++D+S+ I + ++ TG + + + + + + LA DW+ K LYWTDS
Sbjct: 746 IDFDAQDSTIFFSDMSKHMIFKQKIDGTGREI--LAANRVENVESLAFDWISKNLYWTDS 803
Query: 128 ETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRK 187
I V L +R+ + Q L+ PR++ + P GY+++TDW +I RA DGS
Sbjct: 804 HYKSISVMRLADKTRRTVV-QYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLL 862
Query: 188 IIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVE-GSLTHPFALTLS 246
++++ + WPNGL ID +LYW DA I + DG R+++ +THPF L +
Sbjct: 863 PVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIF 922
Query: 247 GDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEED---N 303
G+ L++TDW+ +I K GG+ I S + + ++ Q + C + N
Sbjct: 923 GEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNA-CNQPTHPN 981
Query: 304 GGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCK 337
G CSH C P+ C CP G++L N TC+
Sbjct: 982 GDCSHFCFPVPNFQ-RVCGCPYGMRLASNHLTCE 1014
Score = 151 bits (381), Expect = 6e-36
Identities = 103/351 (29%), Positives = 176/351 (50%), Gaps = 31/351 (8%)
Query: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDM--KTCIVPEA--FLVFTSRAAIHRI 658
N C ++ G C C T + C C G +SD K C + L+ I +
Sbjct: 4009 NEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKY 4067
Query: 659 SLETNNNDVAIPLTGVKEASALDFD---VSNNHIYWT----DVSLKTISRAFMNG----- 706
+L + + +A D+D + + +Y+T I RA++
Sbjct: 4068 NLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGR 4127
Query: 707 SSVEHVVEFGLDY---PEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNP 763
+++ V+ L Y P+G+AVDW+G+++YW+D RIEVA+LDG++R+ L+ DLD P
Sbjct: 4128 NNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQP 4187
Query: 764 RSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYA-DQRLYWT 821
++A++P G ++WT+WG +P+I A+M+G + LV + +G L+IDY + R+YW+
Sbjct: 4188 AAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWS 4247
Query: 822 DLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADK--TSGRNR 879
D ++IE+ G +R VIA + +P+ L + D +YW + + +K + +
Sbjct: 4248 DFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEK 4307
Query: 880 TLIQGHLDFVMDILVFHSSRQDGLNDCMHN--NGQCGQLCLAIPGGHRCGC 928
TL+ ++ + +FH R N + N C LCL PGG+ C C
Sbjct: 4308 TLVVN--PWLTQVRIFHQLR---YNKSVPNLCKQICSHLCLLRPGGYSCAC 4353
Score = 109 bits (272), Expect = 2e-23
Identities = 48/113 (42%), Positives = 63/113 (55%), Gaps = 2/113 (1%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRC 1317
TCS Q C+ G+ CIP +RCD +C D +DE C + Q C G C + +C
Sbjct: 107 TCSSHQITCSNGQ--CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKC 164
Query: 1318 DGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
D + DC+D SDE +C ICL N+F C +G+C+ CD DC DGSDE C
Sbjct: 165 DWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC 217
Score = 105 bits (263), Expect = 3e-22
Identities = 54/125 (43%), Positives = 65/125 (52%), Gaps = 6/125 (4%)
Query: 1255 EPPTCSP-DQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCV 1311
E TC P F C CIP W+CDG +C D SDEE C C+ ++F C QC+
Sbjct: 3715 EERTCHPVGDFRCKNHH--CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCI 3772
Query: 1312 DLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
R CD DC D SDE DC+ C P F+C SG CV + +CD DC+D SDE C
Sbjct: 3773 PSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Query: 1371 EITKP 1375
P
Sbjct: 3833 PTRFP 3837
Score = 103 bits (258), Expect = 1e-21
Identities = 56/138 (40%), Positives = 73/138 (52%), Gaps = 10/138 (7%)
Query: 1242 VHLVLLQNLLTCGEPPT---CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV- 1297
V LL L+ C P + C F C +G CIP WRCDG +C D +DE GC V
Sbjct: 8 VACTLLLALVACLAPASGQECDSAHFRCGSGH--CIPADWRCDGTKDCSDDADEIGCAVV 65
Query: 1298 -CSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDE-ADC-DAICLPNQFRCASGQCVLIKQ 1353
C F C + GQC+ CD + DC D SDE DC + C +Q C++GQC+ +
Sbjct: 66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEY 125
Query: 1354 QCDSFPDCIDGSDELMCE 1371
+CD DC DG+DE C+
Sbjct: 126 RCDHVRDCPDGADENDCQ 143
Score = 102 bits (254), Expect = 3e-21
Identities = 50/120 (41%), Positives = 60/120 (50%), Gaps = 10/120 (8%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDL 1313
P C+ +F C + CIP W CD + +C D SDE C + C F C G CV
Sbjct: 3756 PRECTESEFRCVNQQ--CIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHS 3813
Query: 1314 RLRCDGEADCQDRSDEADC------DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
L+CDG ADC D SDEADC A C F C + C+ +CD DC DGSDE
Sbjct: 3814 ELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE 3873
Score = 100 bits (248), Expect = 1e-20
Identities = 48/124 (38%), Positives = 67/124 (54%), Gaps = 9/124 (7%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDLRL 1315
TCS ++F C G CIP +RCD +C D SDE GC C QF C G+C+
Sbjct: 2992 TCSENEFTCGYGL--CIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTF 3049
Query: 1316 RCDGEADCQDRSDEA-----DCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
CD + DC D SDE + C P++F+C +G+C+ + + C+ DC+D SDE C
Sbjct: 3050 VCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Query: 1371 EITK 1374
I +
Sbjct: 3110 GINE 3113
Score = 95.1 bits (235), Expect = 5e-19
Identities = 55/157 (35%), Positives = 75/157 (47%), Gaps = 20/157 (12%)
Query: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1279
DNG C + + +C V + + C E C ++F+C GE CIP A+
Sbjct: 153 DNGACYNT-------SQKCDWKVDCRDSSDEINCTE--ICLHNEFSCGNGE--CIPRAYV 201
Query: 1280 CDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA--- 1334
CD +C D SDE C P C QF C G+C+ CDGE DC+D DE C++
Sbjct: 202 CDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPH 261
Query: 1335 ---ICLPNQFRC-ASGQCVLIKQQCDSFPDCIDGSDE 1367
C P ++ C SG+C+ I + CD DC DE
Sbjct: 262 DVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298
Score = 94.4 bits (233), Expect = 8e-19
Identities = 50/117 (42%), Positives = 61/117 (52%), Gaps = 7/117 (5%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE-EGCP--VCSAAQFPCARGQCVDLR 1314
TC F C + E CIP +W CD +CDD SDE + C CS+ Q C+ GQC+
Sbjct: 66 TCQQGYFKCQS-EGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSE 124
Query: 1315 LRCDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
RCD DC D +DE DC C Q C +G C Q+CD DC D SDE+ C
Sbjct: 125 YRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINC 179
Score = 94.4 bits (233), Expect = 8e-19
Identities = 55/164 (33%), Positives = 69/164 (42%), Gaps = 51/164 (31%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCD------------------------------------ 1281
TC P QF CA G CIP AW+CD
Sbjct: 3634 TCRPGQFRCANGR--CIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYR 3691
Query: 1282 ---------GFPECDDQSDEEGCP--VC-SAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1329
G +C D SDE+GC C F C C+ LR +CDG+ DC D SDE
Sbjct: 3692 CIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDE 3751
Query: 1330 ADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
+C C ++FRC + QC+ + CD + DC D SDE CE+
Sbjct: 3752 ENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEM 3795
Score = 89.4 bits (220), Expect = 3e-17
Identities = 57/165 (34%), Positives = 69/165 (41%), Gaps = 49/165 (29%)
Query: 1253 CGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-CSAAQFPCARG-QC 1310
C TC P QF C CI ++ CDG +C D SDE GC + C+A+QF CA G +C
Sbjct: 1143 CNSTETCQPSQFNCPNHR--CIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKC 1200
Query: 1311 VDLRLRCDGEADCQDRSDEADC-----------------DAICLPN-------------- 1339
+ + RCDG DC D SDEA C D IC+PN
Sbjct: 1201 IGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGS 1260
Query: 1340 --------------QFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
F C +G C+ CD DC D SDE C
Sbjct: 1261 DEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 87.0 bits (214), Expect = 1e-16
Identities = 47/118 (39%), Positives = 61/118 (51%), Gaps = 9/118 (7%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC----PVCSAAQFPCARGQCVDL 1313
TC C I CIP + CDG +C D SDE CS+++F CA G+C+
Sbjct: 2821 TCQSGYTKCHNSNI-CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQ 2879
Query: 1314 RLRCDGEADCQDRSDE-ADC---DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
CD E DC D SDE A C + CL ++F+C G+C+ + CD DC D SDE
Sbjct: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 86.7 bits (213), Expect = 2e-16
Identities = 84/357 (23%), Positives = 148/357 (41%), Gaps = 28/357 (7%)
Query: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTL--DPSSRNCSPP--TTFLLFSQKSAISR 958
+N+C G C Q C G + C CA +T D + C+ + LL I +
Sbjct: 4008 INEC-EQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRK 4066
Query: 959 MIPDDQHSPDLILPLHGLRNVKAIDYD------PLDKFIYWVDGRQN----IKRA---KD 1005
+ + L ++A+DYD L Y V G + IKRA
Sbjct: 4067 YNLSSERFSEY---LQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNF 4123
Query: 1006 DGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGD 1065
+ + ++ + QP +++D R ++W+ I V +L G ++ D
Sbjct: 4124 ESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTD 4183
Query: 1066 RDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDN-TLG 1124
D+P AI VN + G +++T+ + KIE A ++G +R +L L P L +D
Sbjct: 4184 LDQPAAIAVNPKLGLMFWTDW-GKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNND 4242
Query: 1125 KLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTT 1184
+++W D IE+ G +R + + P L I LYWI +++ + + K
Sbjct: 4243 RIYWSDFKEDVIETIKYDGTDRRVIA-KEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFG 4301
Query: 1185 GDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
K+ + LT + ++ + + C + CSH+C+ + G C+CP
Sbjct: 4302 QGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQI---CSHLCLLRPGGY-SCACP 4354
Score = 85.9 bits (211), Expect = 3e-16
Identities = 50/124 (40%), Positives = 59/124 (47%), Gaps = 18/124 (14%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---CSAAQFPCARGQCVD 1312
P C D+F C I CIP W CDG P+C SDE V C ++ F C G C+
Sbjct: 1227 PGMCHSDEFQCQEDGI-CIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIH 1285
Query: 1313 LRLRCDGEADCQDRSDEADCDAICLPNQ-FRCASGQ--------CVLIKQQCDSFPDCID 1363
CD + DC D SDE DC P Q FRC S Q CV + CD DC +
Sbjct: 1286 RAWLCDRDNDCGDMSDEKDC-----PTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPN 1340
Query: 1364 GSDE 1367
G+DE
Sbjct: 1341 GTDE 1344
Score = 85.1 bits (209), Expect = 5e-16
Identities = 58/184 (31%), Positives = 68/184 (36%), Gaps = 55/184 (29%)
Query: 1252 TCGEPP-TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--------EGCP------ 1296
+CG TC D+F C G CIP W CDG +C D SDE + C
Sbjct: 2898 SCGHSERTCLADEFKCDGGR--CIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLC 2955
Query: 1297 ------------------------------------VCSAAQFPCARGQCVDLRLRCDGE 1320
CS +F C G C+ RCD
Sbjct: 2956 VNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRH 3015
Query: 1321 ADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDD 1379
DC D SDE C C NQF C +G+C+ CD DC DGSDELM + P
Sbjct: 3016 NDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELM-HLCHTPEPT 3074
Query: 1380 SPAH 1383
P H
Sbjct: 3075 CPPH 3078
Score = 76.6 bits (187), Expect = 2e-13
Identities = 44/130 (33%), Positives = 58/130 (44%), Gaps = 16/130 (12%)
Query: 1257 PTCSPDQFACATGEIDC-----IPGAWRCDGFPECDDQSDEE-----GCPVCSAAQFPCA 1306
PT PD C +C IP W+CDG +C D SDEE P S +F C
Sbjct: 3833 PTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCD 3892
Query: 1307 RGQCVDLRLRCDGEADCQDRSDEAD------CDAICLPNQFRCASGQCVLIKQQCDSFPD 1360
+C+ C+G DC D +DE + C +++C +G C+ CD D
Sbjct: 3893 NNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADD 3952
Query: 1361 CIDGSDELMC 1370
C D SDEL C
Sbjct: 3953 CGDWSDELGC 3962
Score = 62.0 bits (149), Expect = 4e-09
Identities = 36/98 (36%), Positives = 48/98 (48%), Gaps = 10/98 (10%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPC-ARGQC 1310
P TC F C G +CI AW CD +C D SDE+ CP C + Q+ C C
Sbjct: 1268 PKTCPSSYFHCDNG--NCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNIC 1325
Query: 1311 VDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQC 1348
V+L + CDG DC + +DE+ +C N +G C
Sbjct: 1326 VNLSVVCDGIFDCPNGTDES---PLCNGNSCSDFNGGC 1360
Score = 53.5 bits (127), Expect = 2e-06
Identities = 42/141 (29%), Positives = 58/141 (41%), Gaps = 22/141 (15%)
Query: 1225 SHICIA---KGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCD 1281
+H+CI K DG C + L C + P SP++F C CI C+
Sbjct: 3851 NHVCIPPYWKCDGDDDCGDGSD----EELHLCLDVPCNSPNRFRCDNNR--CIYSHEVCN 3904
Query: 1282 GFPECDDQSDE--EGC-----PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA 1334
G +C D +DE E C C+ ++ C G C+ CD DC D SDE C+
Sbjct: 3905 GVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
Query: 1335 ICLPNQFRCASGQCVLIKQQC 1355
+ CA C +Q C
Sbjct: 3965 ---GKERTCAENIC---EQNC 3979
Score = 39.7 bits (91), Expect = 0.024
Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 4/50 (8%)
Query: 1323 CQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
C + +CD+ FRC SG C+ +CD DC D +DE+ C +
Sbjct: 19 CLAPASGQECDSA----HFRCGSGHCIPADWRCDGTKDCSDDADEIGCAV 64
Score = 39.3 bits (90), Expect = 0.031
Identities = 25/92 (27%), Positives = 43/92 (46%), Gaps = 11/92 (11%)
Query: 1213 SAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEID 1272
+ + C+ NGGC+H C+ + G +C CP+ +L + TC + C D +
Sbjct: 1349 NGNSCSDFNGGCTHECVQEPFGA-KCLCPLGFLLANDSKTCEDIDEC--DILGSCSQHCY 1405
Query: 1273 CIPGAWRCDGFPECDD----QSDEEGCPVCSA 1300
+ G++RC CD +SD C V ++
Sbjct: 1406 NMRGSFRC----SCDTGYMLESDGRTCKVTAS 1433
Score = 39.3 bits (90), Expect = 0.031
Identities = 30/99 (30%), Positives = 38/99 (38%), Gaps = 9/99 (9%)
Query: 1253 CGEP-PTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQ 1309
C P PTC P +F C G CI C+ +C D SDE+GC + C
Sbjct: 3068 CHTPEPTCPPHEFKCDNGR--CIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHN 3125
Query: 1310 CVD--LRLRCDGEADCQDRSDEADCDAI--CLPNQFRCA 1344
C D C + SD+ C I C F C+
Sbjct: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCS 3164
Score = 38.9 bits (89), Expect = 0.041
Identities = 18/38 (47%), Positives = 23/38 (60%), Gaps = 1/38 (2%)
Query: 1332 CDAICLPNQFRCASGQ-CVLIKQQCDSFPDCIDGSDEL 1368
C +C QF CA+ + C+ I +CD DC DGSDEL
Sbjct: 3508 CMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDEL 3545
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 399 bits (1024), Expect = e-110
Identities = 193/231 (83%), Positives = 209/231 (90%)
Query: 383 LEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEV 442
+EG+VYWTDDEV AIRRAYLDGSGAQTL+NT+INDPD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 443 TRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASL 502
T LN TS KILVSED+DEPRAIALHP MGL YW DWGENP+I+ ANLD QE RVLVNASL
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 503 GWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 562
GWPNGLALDLQEGKLYWGDAKTDKIE I+VD TKR+TLL+DKLPHIF FTLLGDFIYWT
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 563 WQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCS 613
WQ SI+RVHKVKA+RDVIIDQLPDLMGLKAVNV KVVGTNP ADRNGG +
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
Score = 191 bits (484), Expect = 6e-48
Identities = 97/244 (39%), Positives = 144/244 (59%), Gaps = 4/244 (1%)
Query: 74 KGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIE 133
+G VYWTD AI++ YL+ +GA Q ++ + + PD +A +WV + LYWT + T IE
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGA--QTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
Query: 134 VANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSD 193
V LN TS K+L +D+D+PRAIAL P G YW DWGE P I+RA +D +++V++
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
Query: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
+ WPNGL +DL+E KLYW DAK I ++D + RQ +++ L H F TL GD +YWT
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
Query: 254 DWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLS 313
WQ SI +K R I+ L M ++ ++ ++ + + NGG +
Sbjct: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADR-NGGAATCASSR 237
Query: 314 PSEP 317
P++P
Sbjct: 238 PTQP 241
Score = 161 bits (407), Expect = 5e-39
Identities = 83/226 (36%), Positives = 126/226 (55%), Gaps = 3/226 (1%)
Query: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
H+YWTD + I RA+++GS + ++ ++ P+ +AV+W+ ++LYW TGT IEV L
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRA 806
+ ++LV D+D PR++AL P G YW +WG P I RA +D LV+ +G
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNL 865
N L +D + +LYW D T+ IE+ ++ +R ++ D LPH F T D+IYWT W
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNG 911
HSI+R K NR +I L +M + + + G N NG
Sbjct: 184 HSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228
Score = 99.0 bits (245), Expect = 3e-20
Identities = 76/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 987 LDKFIYWVDGRQ-NIKRAKDDGT--QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCE 1043
++ +YW D I+RA DG+ Q + T ++ P D++++ +R+L+WT
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND-------PDDIAVNWVARSLYWTHT 53
Query: 1044 ATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTER 1103
T I V L+ + +++ D D+PRAI ++ E G Y+ + + +I+RA LD E
Sbjct: 54 GTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP-EIKRANLDRQEL 112
Query: 1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL 1163
VL L P L +D GKL+W DA +IE+ + R TL + T+L
Sbjct: 113 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
Query: 1164 GKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGG 1223
G +YW Q I+RV K + R I ++ L G+ AV + +P A NGG
Sbjct: 173 GDFIYWTAWQHHSIKRVHKVKAN-RDVIIDQLPDLMGLKAVNVDKV--VGTNPHADRNGG 229
Query: 1224 CSHICIAKGDGTPRCSCP 1241
+ C + P + P
Sbjct: 230 AA-TCASSRPTQPGLAAP 246
Score = 34.7 bits (78), Expect = 0.77
Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 21/229 (9%)
Query: 250 LYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFF-HTRCEEDNGGC-- 306
+YWTD + +I G + I + + P DI V R ++ HT E C
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 307 --SHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTD 364
SH L+S P + L + G + +++R +LD +
Sbjct: 65 STSHKILVSEDMDE-----PRAIALHP-----EMGLTYWIDWGENPEIKRANLDRQELRV 114
Query: 365 IVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVD 424
+V + +A+D EG +YW D + I +D + QTL+ ++ P
Sbjct: 115 LVNASLGWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFT 170
Query: 425 WVARNLYWTDTGTDRIEVTRLNGTSRKILVSE--DLDEPRAIALHPVMG 471
+ +YWT I+ +R +++ + DL +A+ + V+G
Sbjct: 171 LLGDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 399 bits (1024), Expect = e-110
Identities = 193/231 (83%), Positives = 209/231 (90%)
Query: 383 LEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEV 442
+EG+VYWTDDEV AIRRAYLDGSGAQTL+NT+INDPD IAV+WVAR+LYWT TGT+ IEV
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 443 TRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASL 502
T LN TS KILVSED+DEPRAIALHP MGL YW DWGENP+I+ ANLD QE RVLVNASL
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 503 GWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 562
GWPNGLALDLQEGKLYWGDAKTDKIE I+VD TKR+TLL+DKLPHIF FTLLGDFIYWT
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTA 180
Query: 563 WQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCS 613
WQ SI+RVHKVKA+RDVIIDQLPDLMGLKAVNV KVVGTNP ADRNGG +
Sbjct: 181 WQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNGGAA 231
Score = 191 bits (484), Expect = 6e-48
Identities = 97/244 (39%), Positives = 144/244 (59%), Gaps = 4/244 (1%)
Query: 74 KGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIE 133
+G VYWTD AI++ YL+ +GA Q ++ + + PD +A +WV + LYWT + T IE
Sbjct: 2 EGHVYWTDDEVWAIRRAYLDGSGA--QTLINTKINDPDDIAVNWVARSLYWTHTGTEHIE 59
Query: 134 VANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSD 193
V LN TS K+L +D+D+PRAIAL P G YW DWGE P I+RA +D +++V++
Sbjct: 60 VTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNAS 119
Query: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
+ WPNGL +DL+E KLYW DAK I ++D + RQ +++ L H F TL GD +YWT
Sbjct: 120 LGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWT 179
Query: 254 DWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLS 313
WQ SI +K R I+ L M ++ ++ ++ + + NGG +
Sbjct: 180 AWQHHSIKRVHK-VKANRDVIIDQLPDLMGLKAVNVDKVVGTNPHADR-NGGAATCASSR 237
Query: 314 PSEP 317
P++P
Sbjct: 238 PTQP 241
Score = 161 bits (407), Expect = 5e-39
Identities = 83/226 (36%), Positives = 126/226 (55%), Gaps = 3/226 (1%)
Query: 688 HIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARL 747
H+YWTD + I RA+++GS + ++ ++ P+ +AV+W+ ++LYW TGT IEV L
Sbjct: 4 HVYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 748 DGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVD-KVGRA 806
+ ++LV D+D PR++AL P G YW +WG P I RA +D LV+ +G
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 807 NDLTIDYADQRLYWTDLDTNMIESSNMLGQER-VVIADDLPHPFGLTQYSDYIYWTDWNL 865
N L +D + +LYW D T+ IE+ ++ +R ++ D LPH F T D+IYWT W
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAWQH 183
Query: 866 HSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNG 911
HSI+R K NR +I L +M + + + G N NG
Sbjct: 184 HSIKRVHKVKA-NRDVIIDQLPDLMGLKAVNVDKVVGTNPHADRNG 228
Score = 99.0 bits (245), Expect = 3e-20
Identities = 76/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)
Query: 987 LDKFIYWVDGRQ-NIKRAKDDGT--QPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCE 1043
++ +YW D I+RA DG+ Q + T ++ P D++++ +R+L+WT
Sbjct: 1 MEGHVYWTDDEVWAIRRAYLDGSGAQTLINTKIND-------PDDIAVNWVARSLYWTHT 53
Query: 1044 ATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTER 1103
T I V L+ + +++ D D+PRAI ++ E G Y+ + + +I+RA LD E
Sbjct: 54 GTEHIEVTCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENP-EIKRANLDRQEL 112
Query: 1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTIL 1163
VL L P L +D GKL+W DA +IE+ + R TL + T+L
Sbjct: 113 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLL 172
Query: 1164 GKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGG 1223
G +YW Q I+RV K + R I ++ L G+ AV + +P A NGG
Sbjct: 173 GDFIYWTAWQHHSIKRVHKVKAN-RDVIIDQLPDLMGLKAVNVDKV--VGTNPHADRNGG 229
Query: 1224 CSHICIAKGDGTPRCSCP 1241
+ C + P + P
Sbjct: 230 AA-TCASSRPTQPGLAAP 246
Score = 34.7 bits (78), Expect = 0.77
Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 21/229 (9%)
Query: 250 LYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFF-HTRCEEDNGGC-- 306
+YWTD + +I G + I + + P DI V R ++ HT E C
Sbjct: 5 VYWTDDEVWAIRRAYLDGSGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCLN 64
Query: 307 --SHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTD 364
SH L+S P + L + G + +++R +LD +
Sbjct: 65 STSHKILVSEDMDE-----PRAIALHP-----EMGLTYWIDWGENPEIKRANLDRQELRV 114
Query: 365 IVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVD 424
+V + +A+D EG +YW D + I +D + QTL+ ++ P
Sbjct: 115 LVNASLGWPNGLALDLQ--EGKLYWGDAKTDKIEAISVDETKRQTLLKDKL--PHIFRFT 170
Query: 425 WVARNLYWTDTGTDRIEVTRLNGTSRKILVSE--DLDEPRAIALHPVMG 471
+ +YWT I+ +R +++ + DL +A+ + V+G
Sbjct: 171 LLGDFIYWTAWQHHSIKRVHKVKANRDVIIDQLPDLMGLKAVNVDKVVG 219
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 248 bits (634), Expect = 3e-65
Identities = 128/320 (40%), Positives = 196/320 (61%), Gaps = 13/320 (4%)
Query: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
P L+F NRRD+R + G + E +V L + A+D + ++W D+S++AI +
Sbjct: 441 PSLIFTNRRDIRKI--GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASI 498
Query: 93 N-QTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLD 151
+ + G V+ +I + +P +A DWV K +YWTD+ + I VA L+GT RK LF DL
Sbjct: 499 DDKVGRHVK--MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
Query: 152 QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYW 211
+P +IA+DP G++YW+DWGE +IE+AGM+G R+ +V +DI WPNG+T+DL + +LYW
Sbjct: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
Query: 212 ADAKLSFIHRANLDGSFRQKVVEG--SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
D+KL + +L+G R+ V++ L HP ALT+ D +YW D + +++ NK TG
Sbjct: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGS 676
Query: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEED--NGGCSHLCLLSPS----EPFYTCAC 323
+ +++ L DI V + QP CEED NGGC +LCL +P P YTC+C
Sbjct: 677 ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
Query: 324 PTGVQLQDNGRTCKAGAEEV 343
P+G +++NGR C++ A V
Sbjct: 737 PSGYNVEENGRDCQSTATTV 756
Score = 208 bits (530), Expect = 3e-53
Identities = 128/407 (31%), Positives = 206/407 (50%), Gaps = 32/407 (7%)
Query: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISLDT 359
++ G CS +C+ Y C C G Q+ CKA G E L+ R D+R+I L+
Sbjct: 401 QNPGICSQICINLKGG--YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS-GAQTLVNTEINDP 418
++ +V Q +R+ +A+D D ++W D +AI A +D G + + +P
Sbjct: 459 KEYIQLVEQ---LRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 419 DGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDW 478
IAVDWV + +YWTD + I V L+GT RK L + DL EP +IA+ P+ G +YW+DW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 479 GENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRR 538
GE KIE A ++G +RR LV A + WPNG+ LDL + +LYW D+K + ++++G RR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 539 TLLE--DKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVN 595
+L+ + L H T+ D +YW D + ++ +K S +++ L D + +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 596 -VAKVVGTNPCAD--RNGGCSHLCFFTP----HATR--CGCPIGLELLSDMKTCIVPEAF 646
+ + G N C + NGGC +LC P H+ + C CP G + + + C
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
Query: 647 LVF-------------TSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
+ + TS I++ T ++V++P G A A+
Sbjct: 756 VTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAI 802
Score = 193 bits (491), Expect = 1e-48
Identities = 128/423 (30%), Positives = 193/423 (45%), Gaps = 67/423 (15%)
Query: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC---------------------- 640
N C NGGCSH+C C C G EL+ D KTC
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
Query: 641 --------------------IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
+ E L+FT+R I +I LE + + ++ AL
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVAL 474
Query: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDY-PEGMAVDWMGKNLYWADTGT 739
D D++ ++W D+S K I A ++ HV Y P +AVDW+ K +YW D +
Sbjct: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534
Query: 740 NRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTL 799
I VA LDG R+ L DL P S+A+DP G++YW++WG +I +A M+G + L
Sbjct: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594
Query: 800 VD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFGLTQYS 855
V + N +T+D RLYW D +M+ S ++ GQ+R ++ + L HP LT +
Sbjct: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654
Query: 856 DYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ-DGLNDCMHN--NGQ 912
D +YW D ++ A+K +G + +L+ DI+V+H Q G N C + NG
Sbjct: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714
Query: 913 CGQLCLAIP------GGHRCGCASHYTLDPSSRNCSPPTTFLLFSQK--------SAISR 958
C LCL P + C C S Y ++ + R+C T + +S+ SA S
Sbjct: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSG 774
Query: 959 MIP 961
++P
Sbjct: 775 LVP 777
Score = 135 bits (341), Expect = 2e-31
Identities = 98/368 (26%), Positives = 177/368 (48%), Gaps = 22/368 (5%)
Query: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP--PTTFLLFSQKSAISRMI 960
+++C N G C Q+C+ + GG++C C+ Y +D ++ C L+F+ + I ++
Sbjct: 397 IDECQ-NPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
Query: 961 PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQG 1019
+ + L+ LRN A+D D + ++W D Q I A D + +
Sbjct: 456 LERKEYIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
Query: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
NP +++D +T++WT A+ TI+V L G + D +P +I V+ G
Sbjct: 513 YNPAA----IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSG 568
Query: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
++Y+++ + AKIE+A ++G +R L T + P + +D +L+W+D+ L + S
Sbjct: 569 FVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
Query: 1140 DLSGAN-RLTLEDAN-IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH 1197
DL+G + R+ L+ + PL LTI +YWID + + + K TG + + +
Sbjct: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
Query: 1198 LTGIHAVEEVSLEEFSAHPCARD--NGGCSHICIAK---GDGTPR--CSCPVHLVLLQNL 1250
I E+ ++ + C D NGGC ++C+ D +P+ CSCP + +N
Sbjct: 688 AQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENG 746
Query: 1251 LTCGEPPT 1258
C T
Sbjct: 747 RDCQSTAT 754
Score = 119 bits (299), Expect = 2e-26
Identities = 56/126 (44%), Positives = 76/126 (60%), Gaps = 12/126 (9%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC---PV----CSAAQFPCA 1306
PPTC +F C+T CIP +W CD +C DQSDE E C PV C A++ C
Sbjct: 190 PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
Query: 1307 RGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGS 1365
G+C+ + RCDG+ DC+D SDE +C + C P+QF C G C+ +QC+ DC+DGS
Sbjct: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
Query: 1366 DELMCE 1371
DE+ C+
Sbjct: 308 DEVNCK 313
Score = 105 bits (263), Expect = 3e-22
Identities = 55/133 (41%), Positives = 72/133 (54%), Gaps = 11/133 (8%)
Query: 1248 QNLLTCGEPPT----CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAA 1301
++L CG P C + C +GE CI WRCDG P+C D SDE CP C
Sbjct: 224 ESLEQCGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPD 281
Query: 1302 QFPCARGQCVDLRLRCDGEADCQDRSDEADCDAI--CL-PNQFRCASGQCVLIKQQCDSF 1358
QF C G C+ +C+G DC D SDE +C + CL P +F+C SG+C+ I + C+
Sbjct: 282 QFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQE 341
Query: 1359 PDCIDGSDELMCE 1371
DC D SDE + E
Sbjct: 342 QDCRDWSDEPLKE 354
Score = 105 bits (262), Expect = 4e-22
Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
TC + +C CIP +WRCDG +CD DEE C CS +F C+ G+C+
Sbjct: 112 TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNF 171
Query: 1316 RCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
C+G+ DC D SDE DC C ++F+C++ C+ I CD DC D SDE + + +
Sbjct: 172 VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231
Query: 1375 PP 1376
P
Sbjct: 232 QP 233
Score = 102 bits (253), Expect = 4e-21
Identities = 56/163 (34%), Positives = 72/163 (44%), Gaps = 48/163 (29%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCV 1311
G C P QF C G CI W+CDG +C D SDE+ C C+ + F C GQCV
Sbjct: 28 GRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCV 85
Query: 1312 DLRLRCDGEADCQDRSDEA----------------------------------DCDA--- 1334
R +CDG+ DC+D SDE+ DCD+
Sbjct: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
Query: 1335 -------ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
C P++F C+SG+C+ C+ DC DGSDEL C
Sbjct: 146 EENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Score = 33.1 bits (74), Expect = 2.2
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 2/51 (3%)
Query: 1209 LEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTC 1259
L+E + C +NGGCSHIC G C C L+ TCG+ C
Sbjct: 352 LKECHINECLVNNGGCSHICKDLVIGY-ECDCAAGFELIDR-KTCGDIDEC 400
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 246 bits (629), Expect = 1e-64
Identities = 126/314 (40%), Positives = 193/314 (61%), Gaps = 13/314 (4%)
Query: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
P L+F NRRD+R + G + E +V L + A+D + ++W D+S++AI +
Sbjct: 441 PSLIFTNRRDIRKI--GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASI 498
Query: 93 N-QTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLD 151
+ + G V+ +I + +P +A DWV K +YWTD+ + I VA L+GT RK LF DL
Sbjct: 499 DDKVGRHVK--MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
Query: 152 QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYW 211
+P +IA+DP G++YW+DWGE +IE+AGM+G R+ +V +DI WPNG+T+DL + +LYW
Sbjct: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
Query: 212 ADAKLSFIHRANLDGSFRQKVVEG--SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
D+KL + +L+G R+ V++ L HP ALT+ D +YW D + +++ NK TG
Sbjct: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGS 676
Query: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEED--NGGCSHLCLLSPS----EPFYTCAC 323
+ +++ L DI V + QP CEED NGGC +LCL +P P YTC+C
Sbjct: 677 ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
Query: 324 PTGVQLQDNGRTCK 337
P+G +++NGR C+
Sbjct: 737 PSGYNVEENGRDCQ 750
Score = 212 bits (539), Expect = 3e-54
Identities = 127/394 (32%), Positives = 203/394 (51%), Gaps = 34/394 (8%)
Query: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISLDT 359
++ G CS +C+ Y C C G Q+ CKA G E L+ R D+R+I L+
Sbjct: 401 QNPGICSQICINLKGG--YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
Query: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS-GAQTLVNTEINDP 418
++ +V Q +R+ +A+D D ++W D +AI A +D G + + +P
Sbjct: 459 KEYIQLVEQ---LRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
Query: 419 DGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDW 478
IAVDWV + +YWTD + I V L+GT RK L + DL EP +IA+ P+ G +YW+DW
Sbjct: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
Query: 479 GENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRR 538
GE KIE A ++G +RR LV A + WPNG+ LDL + +LYW D+K + ++++G RR
Sbjct: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
Query: 539 TLLE--DKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVN 595
+L+ + L H T+ D +YW D + ++ +K S +++ L D + +
Sbjct: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
Query: 596 -VAKVVGTNPCAD--RNGGCSHLCFFTP----HATR--CGCPIGLELLSDMKTCIVPEAF 646
+ + G N C + NGGC +LC P H+ + C CP G + + + C
Sbjct: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC------ 749
Query: 647 LVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
RI++ T ++V++P G A A+
Sbjct: 750 ---------QRINVTTAVSEVSVPPKGTSAAWAI 774
Score = 189 bits (480), Expect = 2e-47
Identities = 122/395 (30%), Positives = 182/395 (46%), Gaps = 59/395 (14%)
Query: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC---------------------- 640
N C NGGCSH+C C C G EL+ D KTC
Sbjct: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
Query: 641 --------------------IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
+ E L+FT+R I +I LE + + ++ AL
Sbjct: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVAL 474
Query: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDY-PEGMAVDWMGKNLYWADTGT 739
D D++ ++W D+S K I A ++ HV Y P +AVDW+ K +YW D +
Sbjct: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534
Query: 740 NRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTL 799
I VA LDG R+ L DL P S+A+DP G++YW++WG +I +A M+G + L
Sbjct: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594
Query: 800 VD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFGLTQYS 855
V + N +T+D RLYW D +M+ S ++ GQ+R ++ + L HP LT +
Sbjct: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654
Query: 856 DYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ-DGLNDCMHN--NGQ 912
D +YW D ++ A+K +G + +L+ DI+V+H Q G N C + NG
Sbjct: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714
Query: 913 CGQLCLAIP------GGHRCGCASHYTLDPSSRNC 941
C LCL P + C C S Y ++ + R+C
Sbjct: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
Score = 135 bits (340), Expect = 3e-31
Identities = 95/351 (27%), Positives = 172/351 (49%), Gaps = 22/351 (6%)
Query: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP--PTTFLLFSQKSAISRMI 960
+++C N G C Q+C+ + GG++C C+ Y +D ++ C L+F+ + I ++
Sbjct: 397 IDECQ-NPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
Query: 961 PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQG 1019
+ + L+ LRN A+D D + ++W D Q I A D + +
Sbjct: 456 LERKEYIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
Query: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
NP +++D +T++WT A+ TI+V L G + D +P +I V+ G
Sbjct: 513 YNPAA----IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSG 568
Query: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
++Y+++ + AKIE+A ++G +R L T + P + +D +L+W+D+ L + S
Sbjct: 569 FVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
Query: 1140 DLSGAN-RLTLEDAN-IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH 1197
DL+G + R+ L+ + PL LTI +YWID + + + K TG + + +
Sbjct: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
Query: 1198 LTGIHAVEEVSLEEFSAHPCARD--NGGCSHICIAK---GDGTPR--CSCP 1241
I E+ ++ + C D NGGC ++C+ D +P+ CSCP
Sbjct: 688 AQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
Score = 119 bits (299), Expect = 2e-26
Identities = 56/126 (44%), Positives = 76/126 (60%), Gaps = 12/126 (9%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC---PV----CSAAQFPCA 1306
PPTC +F C+T CIP +W CD +C DQSDE E C PV C A++ C
Sbjct: 190 PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
Query: 1307 RGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGS 1365
G+C+ + RCDG+ DC+D SDE +C + C P+QF C G C+ +QC+ DC+DGS
Sbjct: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
Query: 1366 DELMCE 1371
DE+ C+
Sbjct: 308 DEVNCK 313
Score = 105 bits (263), Expect = 3e-22
Identities = 55/133 (41%), Positives = 72/133 (54%), Gaps = 11/133 (8%)
Query: 1248 QNLLTCGEPPT----CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAA 1301
++L CG P C + C +GE CI WRCDG P+C D SDE CP C
Sbjct: 224 ESLEQCGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPD 281
Query: 1302 QFPCARGQCVDLRLRCDGEADCQDRSDEADCDAI--CL-PNQFRCASGQCVLIKQQCDSF 1358
QF C G C+ +C+G DC D SDE +C + CL P +F+C SG+C+ I + C+
Sbjct: 282 QFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQE 341
Query: 1359 PDCIDGSDELMCE 1371
DC D SDE + E
Sbjct: 342 QDCRDWSDEPLKE 354
Score = 105 bits (262), Expect = 4e-22
Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
TC + +C CIP +WRCDG +CD DEE C CS +F C+ G+C+
Sbjct: 112 TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNF 171
Query: 1316 RCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
C+G+ DC D SDE DC C ++F+C++ C+ I CD DC D SDE + + +
Sbjct: 172 VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231
Query: 1375 PP 1376
P
Sbjct: 232 QP 233
Score = 102 bits (253), Expect = 4e-21
Identities = 56/163 (34%), Positives = 72/163 (44%), Gaps = 48/163 (29%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCV 1311
G C P QF C G CI W+CDG +C D SDE+ C C+ + F C GQCV
Sbjct: 28 GRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCV 85
Query: 1312 DLRLRCDGEADCQDRSDEA----------------------------------DCDA--- 1334
R +CDG+ DC+D SDE+ DCD+
Sbjct: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
Query: 1335 -------ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
C P++F C+SG+C+ C+ DC DGSDEL C
Sbjct: 146 EENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Score = 33.1 bits (74), Expect = 2.2
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 2/51 (3%)
Query: 1209 LEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTC 1259
L+E + C +NGGCSHIC G C C L+ TCG+ C
Sbjct: 352 LKECHINECLVNNGGCSHICKDLVIGY-ECDCAAGFELIDR-KTCGDIDEC 400
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 242 bits (617), Expect = 2e-63
Identities = 129/344 (37%), Positives = 196/344 (56%), Gaps = 9/344 (2%)
Query: 302 DNGGCSHLCL-LSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISLDT 359
DNGGCS LC+ LSP + C C G LQ + ++C A G + LL A D+R + D
Sbjct: 443 DNGGCSQLCVPLSPVS--WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDG 500
Query: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPD 419
D+ ++ Q + A+D+DP+E +Y+ ++ I RA +DGS + L+ ++ P+
Sbjct: 501 TDYGTLLSQ--QMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPE 558
Query: 420 GIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG 479
G+AVDW+ R YWTD G I + LNG KI+ E++ +PR IA+HP+ ++WTD G
Sbjct: 559 GLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTG 618
Query: 480 ENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRT 539
NP+IE ++L G R V+ ++ L WP+G+ +D KLYW DAK IE+ N+DG+KRR
Sbjct: 619 INPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRR 678
Query: 540 LLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDL--MGLKAVNVA 597
L ++ + H F + D+++++DW S+ RV+K + +D + Q L L V+
Sbjct: 679 LTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNK-RTGKDRVRLQGSMLKPSSLVVVHPL 737
Query: 598 KVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCI 641
G +PC +NGGC H+C C C G SD KTC+
Sbjct: 738 AKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCL 781
Score = 204 bits (518), Expect = 7e-52
Identities = 110/327 (33%), Positives = 175/327 (53%), Gaps = 6/327 (1%)
Query: 27 APAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEA 86
A + P LLFAN +D+R + G T++ + A+D + +Y+ + +
Sbjct: 477 AASGPQPFLLFANSQDIRHMHFDGTDY-GTLLSQQMGMVYALDHDPVENKIYFAHTALKW 535
Query: 87 IKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLF 146
I++ N G+ + ++ G+ P+GLA DW+G++ YWTD + I ++LNG K++
Sbjct: 536 IERA--NMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIIT 593
Query: 147 WQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEE 206
+++ QPR IA+ P ++WTD G PRIE + + G R +I SD+ WP+G+TID
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLT 653
Query: 207 QKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKR 266
KLYW DAK S I ANLDGS R+++ + + HPFA+ + D ++++DW S+ NKR
Sbjct: 654 DKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKR 713
Query: 267 TGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTG 326
TG R + ++ P + V+ +P C NGGC H+C + C+C G
Sbjct: 714 TGKDRVRLQGSMLKPSSLVVVHPLAKPGADP-CLYQNGGCEHICKKRLGTAW--CSCREG 770
Query: 327 VQLQDNGRTCKAGAEEVLLLARRTDLR 353
+G+TC A LL DL+
Sbjct: 771 FMKASDGKTCLALDGHQLLAGGEVDLK 797
Score = 198 bits (503), Expect = 4e-50
Identities = 106/339 (31%), Positives = 181/339 (53%), Gaps = 8/339 (2%)
Query: 609 NGGCSHLCF-FTPHATRCGCPIGLELLSDMKTCIV--PEAFLVFTSRAAIHRISLE-TNN 664
NGGCS LC +P + C C G +L D K+C P+ FL+F + I + + T+
Sbjct: 444 NGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDY 503
Query: 665 NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMA 724
+ G+ ALD D N IY+ +LK I RA M+GS E ++E G+D PEG+A
Sbjct: 504 GTLLSQQMGM--VYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEEGVDVPEGLA 561
Query: 725 VDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKP 784
VDW+G+ YW D G + I + L+G+ +++ ++ PR +A+ P ++WT+ G P
Sbjct: 562 VDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINP 621
Query: 785 RIVRAFMDGTNCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLG-QERVVIA 842
RI + + G + + + + +TID+ +LYW D ++IE +N+ G + R +
Sbjct: 622 RIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQ 681
Query: 843 DDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDG 902
+D+ HPF + + DY++++DW + S+ R +K +G++R +QG + ++V H + G
Sbjct: 682 NDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKPG 741
Query: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNC 941
+ C++ NG C +C G C C + + C
Sbjct: 742 ADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTC 780
Score = 171 bits (433), Expect = 5e-42
Identities = 178/774 (22%), Positives = 291/774 (37%), Gaps = 168/774 (21%)
Query: 627 CPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSN 686
CP G + TC+ P FL+F+ +I RI E N + + GV + +DF +
Sbjct: 28 CPEGTLAGNGNSTCVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV--SVIMDFHYNE 85
Query: 687 NHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVAR 746
IYW D+ + + R F+NGS E V + GMA++W+ + + W++ I V
Sbjct: 86 KRIYWVDLERQLLQRVFLNGSRQERVCNIEKNV-SGMAINWINEEVIWSNQQEGIITVTD 144
Query: 747 LDGQFRQVLVWRDLDNPRSLALDPTKGYIYWT-EWGGKPRIVRAFMDGTNCMTLVDKVGR 805
+ G +L+ L P ++A+DP + +I+W+ E G + RA +DG L++ +
Sbjct: 145 MKGNNSHILL-SALKYPANVAVDPVERFIFWSSEVAGS--LYRADLDGVGVKALLETSEK 201
Query: 806 ANDLTIDYADQRLYWTDLDTNMIESSNML--------GQERVVIADDLPHPFGLTQYSDY 857
+++D D+RL+W + E SN L G + + F ++ + D
Sbjct: 202 ITAVSLDVLDKRLFWIQYNR---EGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDR 258
Query: 858 IYWTDWNLHSIERADKTSGRNRTLIQGHLDFVM--DILVFHSSRQ--------------- 900
I+++ W + +I A+K +G++ I H FV ++ V H Q
Sbjct: 259 IFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLC 318
Query: 901 ------------------------------------DGLNDCMHNNGQCGQLCLAIPGGH 924
+ +N+C N C C PG +
Sbjct: 319 KLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSY 378
Query: 925 RCGCASHYTLDPSSRNC---------------------------SPPTTFLLFSQKSAIS 957
C C + L P + C P + L K+
Sbjct: 379 YCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSG 438
Query: 958 RMIPDDQHSPDLILPLHGLR-------------NVKAIDYDPLDKFIYWVDGRQNIKRAK 1004
PD+ L +PL + + K+ F+ + + Q+I+
Sbjct: 439 CSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANS-QDIRHMH 497
Query: 1005 DDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRG 1064
DGT L S G + L D +++ A I + G ++
Sbjct: 498 FDGTDYGTLLSQQMG-----MVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLIEE 552
Query: 1065 DRDKPRAIVVNAERGYLYFTNMQDRA-AKIERAALDGTEREVLFTTGLIRPVALVVDNTL 1123
D P + V+ Y+T DR + I R+ L+G +++ + +P + V
Sbjct: 553 GVDVPEGLAVDWIGRRFYWT---DRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMA 609
Query: 1124 GKLFWVDADLK-RIESCDLSGANRLTLEDANIVQPLGLTI--LGKHLYWIDRQQQMIE-- 1178
+LFW D + RIES L G RL + ++++ P G+TI L LYW D +Q +IE
Sbjct: 610 KRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMA 669
Query: 1179 ---------------------------------------RVEKTTGDKRTRIQGRVAHLT 1199
RV K TG R R+QG + +
Sbjct: 670 NLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPS 729
Query: 1200 GIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTC 1253
+ V L + A PC NGGC HIC K GT CSC + + TC
Sbjct: 730 SLVVVH--PLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGFMKASDGKTC 780
Score = 98.6 bits (244), Expect = 4e-20
Identities = 72/327 (22%), Positives = 154/327 (47%), Gaps = 26/327 (7%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C PA P L+F++ + +D G E +V +G+ + +DF +++ +YW D+
Sbjct: 41 CVGPA---PFLIFSHGNSIFRIDTEGTNYEQLVVDAGV--SVIMDFHYNEKRIYWVDLER 95
Query: 85 EAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKV 144
+ +++ +LN + Q V + + G+A +W+ +++ W++ + I V ++ G + +
Sbjct: 96 QLLQRVFLN---GSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHI 152
Query: 145 LFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDL 204
L L P +A+DP +++W+ + RA +DG K ++++ +++D+
Sbjct: 153 LL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVGVKALLETSEKI-TAVSLDV 209
Query: 205 EEQKLYWA----DAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSI 260
+++L+W + S I + DG + + FA++L GD ++++ W+ ++I
Sbjct: 210 LDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTI 269
Query: 261 HACNKRTGGKRKEI-LSALYSPM-DIQVLSQERQPFF--------HTRCEEDNGGCSHLC 310
NK TG I L + + P+ +++V+ QP C+ G CS
Sbjct: 270 WIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS-T 328
Query: 311 LLSPSEPFYTCACPTGVQLQDNGRTCK 337
+ + C C G L + + C+
Sbjct: 329 VCGQDLQSHLCMCAEGYALSRDRKYCE 355
Score = 67.4 bits (163), Expect = 1e-10
Identities = 96/457 (21%), Positives = 171/457 (37%), Gaps = 107/457 (23%)
Query: 941 CSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD-GRQN 999
C P FL+FS ++I R+ + + L++ G+ + Y+ +K IYWVD RQ
Sbjct: 41 CVGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDA-GVSVIMDFHYN--EKRIYWVDLERQL 97
Query: 1000 IKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMG 1059
++R +G++ + N ++ ++I+ + + W+ + I V + G
Sbjct: 98 LQRVFLNGSRQ------ERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSH 151
Query: 1060 VVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVV 1119
++L + P + V+ ++++++ + A + RA LDG + L T + A+ +
Sbjct: 152 ILLSALK-YPANVAVDPVERFIFWSS--EVAGSLYRADLDGVGVKALLETSE-KITAVSL 207
Query: 1120 DNTLGKLFWV----DADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQ 1175
D +LFW+ + I SCD G + + +++ G +++ + +
Sbjct: 208 DVLDKRLFWIQYNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMK 267
Query: 1176 MIERVEKTTGDKRTRIQGR-----VAHLTGIHAVEEVSLEEFSAHP----CARDNGGCS- 1225
I K TG RI + L +H + + E+ + P C G CS
Sbjct: 268 TIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSS 327
Query: 1226 ---------HICI-AKG------------------------------DGTPRCSCPVHLV 1245
H+C+ A+G G+ C+CPV V
Sbjct: 328 TVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGSYYCTCPVGFV 387
Query: 1246 LL------QNLLTC--------------GEPPTC-------------------SPDQFAC 1266
LL L++C E P C SPD C
Sbjct: 388 LLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCSGCSSPDNGGC 447
Query: 1267 ATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQF 1303
+ + P +W CD FP D Q DE+ C F
Sbjct: 448 SQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPF 484
Score = 37.7 bits (86), Expect = 0.091
Identities = 15/61 (24%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 372 IRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLY 431
+++ + DP+E +++W+ + ++ RA LDG G + L+ T +++D + + L+
Sbjct: 157 LKYPANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETS-EKITAVSLDVLDKRLF 215
Query: 432 W 432
W
Sbjct: 216 W 216
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 241 bits (614), Expect = 5e-63
Identities = 122/329 (37%), Positives = 191/329 (58%), Gaps = 13/329 (3%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 285 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 342
Query: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 343 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 402
Query: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 403 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 462
Query: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 463 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 522
Query: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 523 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 582
Query: 316 --EPFYTCACPTGVQLQDNGRTCKAGAEE 342
P YTCACP + L + + C A E
Sbjct: 583 SHSPKYTCACPDTMWLGPDMKRCYRDANE 611
Score = 217 bits (552), Expect = 8e-56
Identities = 128/401 (31%), Positives = 196/401 (48%), Gaps = 62/401 (15%)
Query: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLS-----DMKTCIVPEAF--------- 646
G N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
Query: 647 ----------------------------LVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
L+FT+R + RI L N IP+ +K
Sbjct: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 324
Query: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYW 734
ALD +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW
Sbjct: 325 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 384
Query: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 794
D+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G
Sbjct: 385 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 444
Query: 795 NCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFG 850
+ TLV D + N +T+D QRLYW D + + S + G R + D L HPFG
Sbjct: 445 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 504
Query: 851 LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDC 906
+ + D ++WTD +I A++ +G +++ +L+ DI++FH +Q D
Sbjct: 505 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 564
Query: 907 MHNNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC 941
+ NG C LCL P + C C L P + C
Sbjct: 565 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 209 bits (531), Expect = 2e-53
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNG------------------------- 333
C +NGGCSH+C + + + C CP G QL D
Sbjct: 211 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 268
Query: 334 --------------RTCKA--GAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
+ CKA G L+ R ++RRI L +++ ++ +++ +A
Sbjct: 269 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 325
Query: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 326 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 385
Query: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 386 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 445
Query: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 446 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 505
Query: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 506 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 565
Query: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
NGGC +LC P + C CP + L DMK C
Sbjct: 566 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 127 bits (319), Expect = 9e-29
Identities = 100/409 (24%), Positives = 178/409 (43%), Gaps = 67/409 (16%)
Query: 902 GLNDCMHNNG---------------------------------------QCGQLCLAIPG 922
GLN+C+HNNG C Q+C+ G
Sbjct: 207 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 266
Query: 923 GHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNV 979
+C C Y +D ++NC + L+F+ + + R I + + ++P+ L+NV
Sbjct: 267 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSRLIPM--LKNV 323
Query: 980 KAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRT 1037
A+D + IYW D R+ D + P L Q P L++D +
Sbjct: 324 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKH 381
Query: 1038 LFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAA 1097
++WT TI+V + G + + +PRAI V+ RG++Y+++ D+A KIE++
Sbjct: 382 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSG 440
Query: 1098 LDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN--IV 1155
L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR TL + +
Sbjct: 441 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 500
Query: 1156 QPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE----- 1210
P G+ + ++W D + + I + G + + + + + I E+
Sbjct: 501 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 560
Query: 1211 -EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTC 1253
E S P NGGC ++C+ +P+ C+CP + L ++ C
Sbjct: 561 CELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 605
Score = 96.3 bits (238), Expect = 2e-19
Identities = 48/124 (38%), Positives = 62/124 (50%), Gaps = 9/124 (7%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
Query: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 1367 ELMC 1370
E C
Sbjct: 160 EAGC 163
Score = 94.4 bits (233), Expect = 8e-19
Identities = 50/122 (40%), Positives = 61/122 (50%), Gaps = 11/122 (9%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCA--RGQCV 1311
TC+ F C G CI W+CDG EC D SDE VC A + C +CV
Sbjct: 85 TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
Query: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDEL 1368
RCDGE DC+ +DEA C C ++F+C G CVL + C+ DC DGSDE
Sbjct: 143 PASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEA 202
Query: 1369 MC 1370
C
Sbjct: 203 GC 204
Score = 73.2 bits (178), Expect = 2e-12
Identities = 50/166 (30%), Positives = 69/166 (41%), Gaps = 28/166 (16%)
Query: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1279
DNG C H K DG C ++ TC + C ++ +C C+P +WR
Sbjct: 94 DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147
Query: 1280 CDGFPECDDQSDEEGCP----VCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA- 1334
CDG +C+ +DE GC C +F C G CV C+ E DC D SDEA C
Sbjct: 148 CDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQG 207
Query: 1335 --ICLPN---------------QFRCASGQCVLIKQQCDSFPDCID 1363
CL N + C +G +L ++ C +C D
Sbjct: 208 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 253
Score = 68.2 bits (165), Expect = 6e-11
Identities = 35/93 (37%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCD 1356
C QF C +C+ RCD + DC D SDE DC C + F C +G C+ + +CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 1357 SFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP 1389
+C DGSDE TK PA + GP
Sbjct: 107 GEEECPDGSDESEATCTK---QVCPAEKLSCGP 136
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 211 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 266
Query: 1277 AWRCDGFP 1284
++C+ +P
Sbjct: 267 YFKCECYP 274
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 239 bits (609), Expect = 2e-62
Identities = 120/323 (37%), Positives = 189/323 (58%), Gaps = 13/323 (4%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 414 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 471
Query: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 472 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 531
Query: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 532 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 591
Query: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 592 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 651
Query: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 652 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 711
Query: 316 --EPFYTCACPTGVQLQDNGRTC 336
P YTCACP + L + + C
Sbjct: 712 SHSPKYTCACPDTMWLGPDMKRC 734
Score = 220 bits (560), Expect = 1e-56
Identities = 133/428 (31%), Positives = 207/428 (48%), Gaps = 63/428 (14%)
Query: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLS-----DMKTCIVPEAF--------- 646
G N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
Query: 647 ----------------------------LVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
L+FT+R + RI L N IP+ +K
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453
Query: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYW 734
ALD +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW
Sbjct: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513
Query: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 794
D+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G
Sbjct: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573
Query: 795 NCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFG 850
+ TLV D + N +T+D QRLYW D + + S + G R + D L HPFG
Sbjct: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633
Query: 851 LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDC 906
+ + D ++WTD +I A++ +G +++ +L+ DI++FH +Q D
Sbjct: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693
Query: 907 MHNNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC-SPPTTFLLFSQKSAISRM 959
+ NG C LCL P + C C L P + C P + + S ++R
Sbjct: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753
Query: 960 IPDDQHSP 967
+P +P
Sbjct: 754 VPATTRAP 761
Score = 209 bits (531), Expect = 2e-53
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNG------------------------- 333
C +NGGCSH+C + + + C CP G QL D
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 334 --------------RTCKA--GAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
+ CKA G L+ R ++RRI L +++ ++ +++ +A
Sbjct: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 454
Query: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 574
Query: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 575 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 634
Query: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 635 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 694
Query: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
NGGC +LC P + C CP + L DMK C
Sbjct: 695 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 129 bits (323), Expect = 3e-29
Identities = 106/438 (24%), Positives = 186/438 (42%), Gaps = 68/438 (15%)
Query: 902 GLNDCMHNNG---------------------------------------QCGQLCLAIPG 922
GLN+C+HNNG C Q+C+ G
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
Query: 923 GHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNV 979
+C C Y +D ++NC + L+F+ + + R I + + ++P+ L+NV
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSRLIPM--LKNV 452
Query: 980 KAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRT 1037
A+D + IYW D R+ D + P L Q P L++D +
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKH 510
Query: 1038 LFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAA 1097
++WT TI+V + G + + +PRAI V+ RG++Y+++ D+A KIE++
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSG 569
Query: 1098 LDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN--IV 1155
L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR TL + +
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629
Query: 1156 QPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE----- 1210
P G+ + ++W D + + I + G + + + + + I E+
Sbjct: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689
Query: 1211 -EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTCGEPPTCSPDQF 1264
E S P NGGC ++C+ +P+ C+CP + L ++ C P S
Sbjct: 690 CELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-STSTT 744
Query: 1265 ACATGEIDCIPGAWRCDG 1282
A+ +P R G
Sbjct: 745 TLASTMTRTVPATTRAPG 762
Score = 111 bits (278), Expect = 5e-24
Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 24/175 (13%)
Query: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGE--------PPTCSPDQFACA-TGE 1270
D GC+ +C SC + + CG+ P C P +F C G
Sbjct: 159 DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
Query: 1271 IDCIPGAWRCDGFPECDDQSDEEG--------------CPVCSAAQFPCARGQCVDLRLR 1316
CIP W CD +C+D+SDE +A+QF C G+CV L R
Sbjct: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
Query: 1317 CDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
CDG+ DC+D+SDEADC C ++F+C G CVL + C+ DC DGSDE C
Sbjct: 279 CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 98.6 bits (244), Expect = 4e-20
Identities = 49/119 (41%), Positives = 61/119 (51%), Gaps = 8/119 (6%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCA--RGQCV 1311
TC+ F C G CI W+CDG EC D SDE VC A + C +CV
Sbjct: 85 TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
Query: 1312 DLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
RCDGE DC+ +DEA C +C P++F+C + C+ CD DC DGSDE C
Sbjct: 143 PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 97.8 bits (242), Expect = 7e-20
Identities = 51/144 (35%), Positives = 68/144 (47%), Gaps = 9/144 (6%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
Query: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 1367 ELMCEITKPPSDDSPAHSSAIGPV 1390
E C P + + S + V
Sbjct: 160 EAGCATLCAPHEFQCGNRSCLAAV 183
Score = 91.3 bits (225), Expect = 7e-18
Identities = 51/132 (38%), Positives = 65/132 (49%), Gaps = 20/132 (15%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCAR---GQCVDL 1313
C+P +F C G C+ + CDG +C D SDE GC P C +F C G C+
Sbjct: 167 CAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPE 224
Query: 1314 RLRCDGEADCQDRSDEA------------DCDAICLP-NQFRCASGQCVLIKQQCDSFPD 1360
R CD + DC+DRSDEA A C +QF C SG+CV + +CD D
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 1361 CIDGSDELMCEI 1372
C D SDE C +
Sbjct: 285 CKDKSDEADCPL 296
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 340 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 395
Query: 1277 AWRCDGFP 1284
++C+ +P
Sbjct: 396 YFKCECYP 403
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 239 bits (609), Expect = 2e-62
Identities = 120/323 (37%), Positives = 189/323 (58%), Gaps = 13/323 (4%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 244 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 301
Query: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 302 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 361
Query: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 362 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 421
Query: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 422 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 481
Query: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 482 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 541
Query: 316 --EPFYTCACPTGVQLQDNGRTC 336
P YTCACP + L + + C
Sbjct: 542 SHSPKYTCACPDTMWLGPDMKRC 564
Score = 218 bits (555), Expect = 4e-56
Identities = 132/426 (30%), Positives = 206/426 (48%), Gaps = 63/426 (14%)
Query: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLS-----DMKTCIVPEAF----------- 646
N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 168 NECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
Query: 647 --------------------------LVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
L+FT+R + RI L N IP+ +K AL
Sbjct: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVVAL 285
Query: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYWAD 736
D +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW D
Sbjct: 286 DVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTD 345
Query: 737 TGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNC 796
+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G +
Sbjct: 346 SGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDR 405
Query: 797 MTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFGLT 852
TLV D + N +T+D QRLYW D + + S + G R + D L HPFG+
Sbjct: 406 QTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIA 465
Query: 853 QYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDCMH 908
+ D ++WTD +I A++ +G +++ +L+ DI++FH +Q D +
Sbjct: 466 VFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQ 525
Query: 909 NNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC-SPPTTFLLFSQKSAISRMIP 961
NG C LCL P + C C L P + C P + + S ++R +P
Sbjct: 526 PNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVP 585
Query: 962 DDQHSP 967
+P
Sbjct: 586 ATTRAP 591
Score = 209 bits (531), Expect = 2e-53
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNG------------------------- 333
C +NGGCSH+C + + + C CP G QL D
Sbjct: 170 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 227
Query: 334 --------------RTCKA--GAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
+ CKA G L+ R ++RRI L +++ ++ +++ +A
Sbjct: 228 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 284
Query: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 285 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 344
Query: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 345 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 404
Query: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 405 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 464
Query: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 465 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 524
Query: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
NGGC +LC P + C CP + L DMK C
Sbjct: 525 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 564
Score = 127 bits (319), Expect = 9e-29
Identities = 98/388 (25%), Positives = 176/388 (45%), Gaps = 29/388 (7%)
Query: 913 CGQLCLAIPGGHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDL 969
C Q+C+ G +C C Y +D ++NC + L+F+ + + R I + +
Sbjct: 216 CSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSR 274
Query: 970 ILPLHGLRNVKAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPH 1027
++P+ L+NV A+D + IYW D R+ D + P L Q P
Sbjct: 275 LIPM--LKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPE 330
Query: 1028 DLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQ 1087
L++D + ++WT TI+V + G + + +PRAI V+ RG++Y+++
Sbjct: 331 GLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWG 390
Query: 1088 DRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRL 1147
D+A KIE++ L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR
Sbjct: 391 DQA-KIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRK 449
Query: 1148 TLEDAN--IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVE 1205
TL + + P G+ + ++W D + + I + G + + + + + I
Sbjct: 450 TLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFH 509
Query: 1206 EVSLE------EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTCG 1254
E+ E S P NGGC ++C+ +P+ C+CP + L ++ C
Sbjct: 510 ELKQPRAPDACELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY 565
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDG 1282
P S A+ +P R G
Sbjct: 566 RAPQ-STSTTTLASTMTRTVPATTRAPG 592
Score = 96.3 bits (238), Expect = 2e-19
Identities = 48/124 (38%), Positives = 62/124 (50%), Gaps = 9/124 (7%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
Query: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 1367 ELMC 1370
E C
Sbjct: 160 EAGC 163
Score = 68.2 bits (165), Expect = 6e-11
Identities = 35/93 (37%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCD 1356
C QF C +C+ RCD + DC D SDE DC C + F C +G C+ + +CD
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 1357 SFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP 1389
+C DGSDE TK PA + GP
Sbjct: 107 GEEECPDGSDESEATCTK---QVCPAEKLSCGP 136
Score = 47.0 bits (110), Expect = 1e-04
Identities = 39/143 (27%), Positives = 56/143 (39%), Gaps = 26/143 (18%)
Query: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWR 1279
DNG C H K DG C ++ TC + C ++ +C C+P +WR
Sbjct: 94 DNGHCIHERW-KCDGEEECPDGSD----ESEATCTKQ-VCPAEKLSCGPTSHKCVPASWR 147
Query: 1280 CDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLRL--RCDGEA-----------D 1322
CDG +C+ +DE GC C C+ C DL++ C A D
Sbjct: 148 CDGEKDCEGGADEAGCATWLNECLHNNGGCSH-ICTDLKIGFECTCPAGFQLLDQKTCGD 206
Query: 1323 CQDRSDEADCDAICL--PNQFRC 1343
+ D C IC+ F+C
Sbjct: 207 IDECKDPDACSQICVNYKGYFKC 229
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 170 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 225
Query: 1277 AWRCDGFP 1284
++C+ +P
Sbjct: 226 YFKCECYP 233
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 239 bits (609), Expect = 2e-62
Identities = 120/323 (37%), Positives = 189/323 (58%), Gaps = 13/323 (4%)
Query: 25 CPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSE 84
C A A SP L+F NR +VR +D VK + ++ L++ A+D + + +YW D+S
Sbjct: 414 CKAAAGKSPSLIFTNRHEVRRIDL--VKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSY 471
Query: 85 EAIKQTYLNQTGAAVQNVVI--SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
I Y+++ + V+ L SP+GLA DWV K +YWTDS I VA ++G R
Sbjct: 472 RKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRR 531
Query: 143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
+ LF ++L +PRAIA+DP G+MYW+DWG+ +IE++G++G R+ +V +I WPNG+T+
Sbjct: 532 RTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITL 591
Query: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSI 260
DL Q+LYW D+KL + + G R+ ++ + L+HPF + + D ++WTD + +I
Sbjct: 592 DLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 651
Query: 261 HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCE---EDNGGCSHLCLLSPS-- 315
+ N+ G + + L +P DI + + +QP CE + NGGC +LCL +P
Sbjct: 652 FSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQIS 711
Query: 316 --EPFYTCACPTGVQLQDNGRTC 336
P YTCACP + L + + C
Sbjct: 712 SHSPKYTCACPDTMWLGPDMKRC 734
Score = 220 bits (560), Expect = 1e-56
Identities = 133/428 (31%), Positives = 207/428 (48%), Gaps = 63/428 (14%)
Query: 601 GTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLS-----DMKTCIVPEAF--------- 646
G N C NGGCSH+C C CP G +LL D+ C P+A
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
Query: 647 ----------------------------LVFTSRAAIHRISLETNNNDVAIPLTGVKEAS 678
L+FT+R + RI L N IP+ +K
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM--LKNVV 453
Query: 679 ALDFDVSNNHIYWTDVSLKTISRAFMNGSS----VEHVVEFGLDYPEGMAVDWMGKNLYW 734
ALD +V+ N IYW D+S + I A+M+ +S E +++ L PEG+AVDW+ K++YW
Sbjct: 454 ALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYW 513
Query: 735 ADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 794
D+G I VA +DG R+ L R+L PR++A+DP +G++YW++WG + +I ++ ++G
Sbjct: 514 TDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGV 573
Query: 795 NCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFG 850
+ TLV D + N +T+D QRLYW D + + S + G R + D L HPFG
Sbjct: 574 DRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFG 633
Query: 851 LTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ----DGLNDC 906
+ + D ++WTD +I A++ +G +++ +L+ DI++FH +Q D
Sbjct: 634 IAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELS 693
Query: 907 MHNNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNC-SPPTTFLLFSQKSAISRM 959
+ NG C LCL P + C C L P + C P + + S ++R
Sbjct: 694 VQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRT 753
Query: 960 IPDDQHSP 967
+P +P
Sbjct: 754 VPATTRAP 761
Score = 209 bits (531), Expect = 2e-53
Identities = 122/400 (30%), Positives = 198/400 (49%), Gaps = 63/400 (15%)
Query: 299 CEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNG------------------------- 333
C +NGGCSH+C + + + C CP G QL D
Sbjct: 340 CLHNNGGCSHIC--TDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 334 --------------RTCKA--GAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIA 377
+ CKA G L+ R ++RRI L +++ ++ +++ +A
Sbjct: 398 KCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPM---LKNVVA 454
Query: 378 IDYDPLEGYVYWTDDEVRAIRRAYLDGSG----AQTLVNTEINDPDGIAVDWVARNLYWT 433
+D + +YW D R I AY+D + + L++ +++ P+G+AVDWV +++YWT
Sbjct: 455 LDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWT 514
Query: 434 DTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQE 493
D+G I V ++G R+ L S +L EPRAIA+ P+ G MYW+DWG+ KIE + L+G +
Sbjct: 515 DSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVD 574
Query: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLE--DKLPHIFGF 551
R+ LV+ ++ WPNG+ LDL +LYW D+K ++ I+ G R+TL+ D L H FG
Sbjct: 575 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGI 634
Query: 552 TLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVV-GTNPC---A 606
+ D ++WTD + +I +++ ++ + L + + + K + C
Sbjct: 635 AVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSV 694
Query: 607 DRNGGCSHLCFFTPHAT------RCGCPIGLELLSDMKTC 640
NGGC +LC P + C CP + L DMK C
Sbjct: 695 QPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRC 734
Score = 129 bits (323), Expect = 3e-29
Identities = 106/438 (24%), Positives = 186/438 (42%), Gaps = 68/438 (15%)
Query: 902 GLNDCMHNNG---------------------------------------QCGQLCLAIPG 922
GLN+C+HNNG C Q+C+ G
Sbjct: 336 GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKG 395
Query: 923 GHRCGCASHYTLDPSSRNCSPP---TTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNV 979
+C C Y +D ++NC + L+F+ + + R I + + ++P+ L+NV
Sbjct: 396 YFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRR-IDLVKRNYSRLIPM--LKNV 452
Query: 980 KAIDYDPLDKFIYWVD--GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRT 1037
A+D + IYW D R+ D + P L Q P L++D +
Sbjct: 453 VALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQL--HSPEGLAVDWVHKH 510
Query: 1038 LFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAA 1097
++WT TI+V + G + + +PRAI V+ RG++Y+++ D+A KIE++
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQA-KIEKSG 569
Query: 1098 LDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN--IV 1155
L+G +R+ L + + P + +D +L+WVD+ L ++ S D SG NR TL + +
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629
Query: 1156 QPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLE----- 1210
P G+ + ++W D + + I + G + + + + + I E+
Sbjct: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689
Query: 1211 -EFSAHPCARDNGGCSHICIAK---GDGTPR--CSCPVHLVLLQNLLTCGEPPTCSPDQF 1264
E S P NGGC ++C+ +P+ C+CP + L ++ C P S
Sbjct: 690 CELSVQP----NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQ-STSTT 744
Query: 1265 ACATGEIDCIPGAWRCDG 1282
A+ +P R G
Sbjct: 745 TLASTMTRTVPATTRAPG 762
Score = 111 bits (278), Expect = 5e-24
Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 24/175 (13%)
Query: 1220 DNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGE--------PPTCSPDQFACA-TGE 1270
D GC+ +C SC + + CG+ P C P +F C G
Sbjct: 159 DEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGG 218
Query: 1271 IDCIPGAWRCDGFPECDDQSDEEG--------------CPVCSAAQFPCARGQCVDLRLR 1316
CIP W CD +C+D+SDE +A+QF C G+CV L R
Sbjct: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWR 278
Query: 1317 CDGEADCQDRSDEADCD-AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
CDG+ DC+D+SDEADC C ++F+C G CVL + C+ DC DGSDE C
Sbjct: 279 CDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 98.6 bits (244), Expect = 4e-20
Identities = 49/119 (41%), Positives = 61/119 (51%), Gaps = 8/119 (6%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCA--RGQCV 1311
TC+ F C G CI W+CDG EC D SDE VC A + C +CV
Sbjct: 85 TCADSDFTCDNGH--CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
Query: 1312 DLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
RCDGE DC+ +DEA C +C P++F+C + C+ CD DC DGSDE C
Sbjct: 143 PASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 97.8 bits (242), Expect = 7e-20
Identities = 51/144 (35%), Positives = 68/144 (47%), Gaps = 9/144 (6%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCV 1311
G C DQF C CIP WRCD +C D SDE+ CP C+ + F C G C+
Sbjct: 42 GPAKDCEKDQFQCRNER--CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCI 99
Query: 1312 DLRLRCDGEADCQDRSDEADCDA---ICLPNQFRC--ASGQCVLIKQQCDSFPDCIDGSD 1366
R +CDGE +C D SDE++ +C + C S +CV +CD DC G+D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 1367 ELMCEITKPPSDDSPAHSSAIGPV 1390
E C P + + S + V
Sbjct: 160 EAGCATLCAPHEFQCGNRSCLAAV 183
Score = 91.3 bits (225), Expect = 7e-18
Identities = 51/132 (38%), Positives = 65/132 (49%), Gaps = 20/132 (15%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCAR---GQCVDL 1313
C+P +F C G C+ + CDG +C D SDE GC P C +F C G C+
Sbjct: 167 CAPHEFQC--GNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPE 224
Query: 1314 RLRCDGEADCQDRSDEA------------DCDAICLP-NQFRCASGQCVLIKQQCDSFPD 1360
R CD + DC+DRSDEA A C +QF C SG+CV + +CD D
Sbjct: 225 RWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRD 284
Query: 1361 CIDGSDELMCEI 1372
C D SDE C +
Sbjct: 285 CKDKSDEADCPL 296
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/68 (36%), Positives = 35/68 (51%), Gaps = 4/68 (5%)
Query: 1217 CARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPG 1276
C +NGGCSHIC G C+CP LL TCG+ C D AC+ ++ G
Sbjct: 340 CLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQ-KTCGDIDECK-DPDACSQICVN-YKG 395
Query: 1277 AWRCDGFP 1284
++C+ +P
Sbjct: 396 YFKCECYP 403
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 228 bits (581), Expect = 4e-59
Identities = 120/330 (36%), Positives = 185/330 (56%), Gaps = 13/330 (3%)
Query: 35 LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQ 94
L F NR +VR + + E T ++ L + A+D + + +YW+D+S+ I T L++
Sbjct: 401 LFFTNRHEVRKMTLD--RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDR 458
Query: 95 T-GAAVQNVVIS-GLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQ 152
G + + VIS + +PDGLA DW+ +YWTDS + VA+ G RK LF ++ +
Sbjct: 459 AHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSK 518
Query: 153 PRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWA 212
PRAI +DP HG+MYWTDWG +I++ G++G +V +I WPNG+T+DL +LYW
Sbjct: 519 PRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWV 578
Query: 213 DAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK 270
D+KL I +++G R+ ++E L HPF+L + D ++WTD +I + N+ TG
Sbjct: 579 DSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSD 638
Query: 271 RKEILSALYSPMDIQVLSQERQPFFHTRCEE---DNGGCSHLCL----LSPSEPFYTCAC 323
+ L SP D+ + QP CE NGGC +LCL ++P P +TCAC
Sbjct: 639 VNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCAC 698
Query: 324 PTGVQLQDNGRTCKAGAEEVLLLARRTDLR 353
P G+ L + R+C AE + + +R
Sbjct: 699 PDGMLLARDMRSCLTEAEAAVATQETSTVR 728
Score = 224 bits (572), Expect = 4e-58
Identities = 134/389 (34%), Positives = 206/389 (52%), Gaps = 30/389 (7%)
Query: 298 RCEE-----DNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTD 351
RCE+ D CS LC+ E Y C C G QL + + CKA G+ L R +
Sbjct: 351 RCEDIDECQDPDTCSQLCV--NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE 408
Query: 352 LRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDG----SGA 407
+R+++LD ++T ++ ++R+ +A+D + +YW+D R I LD S
Sbjct: 409 VRKMTLDRSEYTSLI---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY 465
Query: 408 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALH 467
T+++ +I PDG+AVDW+ N+YWTD+ + V G RK L E+ +PRAI +
Sbjct: 466 DTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVD 525
Query: 468 PVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 527
PV G MYWTDWG KI+ L+G + LV ++ WPNG+ LDL G+LYW D+K I
Sbjct: 526 PVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSI 585
Query: 528 EVINVDGTKRRTLLED--KLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQ 584
I+V+G R+T+LED +L H F + D ++WTD +I +++ S +++ +
Sbjct: 586 SSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAEN 645
Query: 585 L--PDLMGLKAVNVAKVVGTNPCAD---RNGGCSHLCF----FTPHATR--CGCPIGLEL 633
L P+ M L N+ + G N C NGGC +LC PH+ + C CP G+ L
Sbjct: 646 LLSPEDMVL-FHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLL 704
Query: 634 LSDMKTCIVPEAFLVFTSRAAIHRISLET 662
DM++C+ V T + R+ + +
Sbjct: 705 ARDMRSCLTEAEAAVATQETSTVRLKVSS 733
Score = 188 bits (478), Expect = 3e-47
Identities = 121/421 (28%), Positives = 199/421 (47%), Gaps = 61/421 (14%)
Query: 598 KVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLS-----DMKTCIVPE-------- 644
K GTN C D NGGCSH+C C CP G +L++ D+ C P+
Sbjct: 311 KECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVN 370
Query: 645 ----------------------------AFLVFTSRAAIHRISLETNNNDVAIPLTGVKE 676
A+L FT+R + +++L+ + IP ++
Sbjct: 371 LEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIP--NLRN 428
Query: 677 ASALDFDVSNNHIYWTDVSLKTISRAFMNG----SSVEHVVEFGLDYPEGMAVDWMGKNL 732
ALD +V++N IYW+D+S + I ++ SS + V+ + P+G+AVDW+ N+
Sbjct: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
Query: 733 YWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMD 792
YW D+ + VA G R+ L + PR++ +DP G++YWT+WG +I + ++
Sbjct: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
Query: 793 GTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADD---LPHP 848
G + +LV + + N +T+D RLYW D + I S ++ G R I +D L HP
Sbjct: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHP 608
Query: 849 FGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQD-GLNDCM 907
F L + D ++WTD +I A++ +G + L+ +L D+++FH+ Q G+N C
Sbjct: 609 FSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCE 668
Query: 908 H---NNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISR 958
+NG C LCL P C C L R+C + +Q+++ R
Sbjct: 669 RTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVR 728
Query: 959 M 959
+
Sbjct: 729 L 729
Score = 140 bits (352), Expect = 1e-32
Identities = 96/373 (25%), Positives = 170/373 (45%), Gaps = 30/373 (8%)
Query: 899 RQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP--PTTFLLFSQKSAI 956
R + +++C + C QLC+ + GG++C C + LDP ++ C +L F+ + +
Sbjct: 351 RCEDIDECQDPD-TCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEV 409
Query: 957 SRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN------IKRAKDDGTQP 1010
+M D LI LRNV A+D + IYW D Q + RA +
Sbjct: 410 RKMTLDRSEYTSLI---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD 466
Query: 1011 FVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPR 1070
V++ Q P L++D ++WT T++V G + R + KPR
Sbjct: 467 TVISRDIQA------PDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPR 520
Query: 1071 AIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD 1130
AIVV+ G++Y+T+ AKI++ L+G + L T + P + +D G+L+WVD
Sbjct: 521 AIVVDPVHGFMYWTDW-GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579
Query: 1131 ADLKRIESCDLSGANRLTL--EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKR 1188
+ L I S D++G NR T+ ++ + P L + ++W D + I + TG
Sbjct: 580 SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDV 639
Query: 1189 TRIQGRVAHLTGIHAVEEVSLEEFSAHPCAR---DNGGCSHICIAKGDGTPR-----CSC 1240
+ + + ++ + + C R NGGC ++C+ P C+C
Sbjct: 640 NLLAENLLSPEDMVLFHNLT-QPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCAC 698
Query: 1241 PVHLVLLQNLLTC 1253
P ++L +++ +C
Sbjct: 699 PDGMLLARDMRSC 711
Score = 113 bits (282), Expect = 2e-24
Identities = 53/119 (44%), Positives = 72/119 (60%), Gaps = 7/119 (5%)
Query: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCV 1311
G+ CS +F C +GE CI +WRCDG P+C D+SDEE C V C +F C+ G C+
Sbjct: 192 GDSSPCSAFEFHCLSGE--CIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCI 249
Query: 1312 DLRLRCDGEADCQDRSDEADCDAICL---PNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
+CD E DC+D SDE C + L PN+F+C SG+C+ + + C+ DC D SDE
Sbjct: 250 HGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
Score = 112 bits (280), Expect = 3e-24
Identities = 52/113 (46%), Positives = 65/113 (57%), Gaps = 3/113 (2%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
TC F+C CIP WRCDG +CD+ SDE+GCP CS +F C G+C+ +
Sbjct: 67 TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQF 126
Query: 1316 RCDGEADCQDRSDEADCDAI-CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
CD + DC D SDEA C + C P F+C S C+ CD+ PDC DGSDE
Sbjct: 127 VCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Score = 110 bits (276), Expect = 8e-24
Identities = 61/152 (40%), Positives = 79/152 (51%), Gaps = 31/152 (20%)
Query: 1233 DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE 1292
DG+ SCPV LTCG P F C + CIP W CD P+C+D SDE
Sbjct: 136 DGSDEASCPV--------LTCG------PASFQCNSST--CIPQLWACDNDPDCEDGSDE 179
Query: 1293 -------------EGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCD-AICLP 1338
+ P CSA +F C G+C+ RCDG DC+D+SDE +C A C P
Sbjct: 180 WPQRCRGLYVFQGDSSP-CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRP 238
Query: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
++F+C+ G C+ +QCD DC D SDE+ C
Sbjct: 239 DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 270
Score = 94.7 bits (234), Expect = 6e-19
Identities = 49/121 (40%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC--PVCSAAQFPCAR--GQCVD 1312
C ++F C G+ CI W CDG EC D SDE E C C + F C +C+
Sbjct: 27 CERNEFQCQDGK--CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
Query: 1313 LRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE 1371
RCDG+ DC + SDE C C ++FRC G+C+ + CDS DC+DGSDE C
Sbjct: 85 QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCP 144
Query: 1372 I 1372
+
Sbjct: 145 V 145
Score = 58.2 bits (139), Expect = 6e-08
Identities = 30/91 (32%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEAD---CDAICLPNQFRCAS--GQCVLIK 1352
C +F C G+C+ + CDG A+CQD SDE+ C F C +C+
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 1353 QQCDSFPDCIDGSDELMCEITKPPSDDSPAH 1383
+CD DC +GSDE C D+ H
Sbjct: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCH 117
Score = 36.2 bits (82), Expect = 0.26
Identities = 19/57 (33%), Positives = 29/57 (50%), Gaps = 6/57 (10%)
Query: 1209 LEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLL-----QNLLTCGEPPTCS 1260
++E + C +NGGCSH+C G C CP L+ +++ C +P TCS
Sbjct: 310 IKECGTNECLDNNGGCSHVCNDLKIGY-ECLCPDGFQLVAQRRCEDIDECQDPDTCS 365
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 198 bits (503), Expect = 4e-50
Identities = 117/313 (37%), Positives = 174/313 (55%), Gaps = 12/313 (3%)
Query: 623 TRCGCPIGLELLSDMKTCIVPEA--FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
T G + L ++ C + E F+++ R +I+R L + + +PLTG++ A AL
Sbjct: 735 TCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATE-QLPLTGLRAAVAL 793
Query: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVV-EFGLDYPEGMAVDWMGKNLYWADTGT 739
DFD +N +YW+D++L I R +NGS+ + V+ GL+ E +A + + + LYW D G
Sbjct: 794 DFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGF 853
Query: 740 NRIEVARLDGQFRQVLVWRD-LDNPRSLALDPTKGYIYWTEWGG-KPRIVRAFMDGTNCM 797
+IEVA DG FR +V LD PR+L L P +G ++WT+WG KP I R+ MDG+
Sbjct: 854 KKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAY 913
Query: 798 TLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
LV + V N +++D DQ +YWTD IE GQ+R VI D+LPHP+ + + +
Sbjct: 914 HLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKN 971
Query: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQL 916
IYW DW+ SI RA K SG ++ L +MD+ +F+ + G N C+ C L
Sbjct: 972 EIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLL 1029
Query: 917 CLAIPGGHR-CGC 928
CL R C C
Sbjct: 1030 CLPKANNSRSCRC 1042
Score = 169 bits (427), Expect = 3e-41
Identities = 110/336 (32%), Positives = 174/336 (51%), Gaps = 34/336 (10%)
Query: 22 LCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTD 81
L CP A + +L+A R+ + D E + ++GL A A+DF + +YW+D
Sbjct: 749 LVPCPL-AEENEFILYAVRKSIYRYDLASGATEQ-LPLTGLRAAVALDFDYEHNCLYWSD 806
Query: 82 VSEEAIKQTYLNQTGAAVQNVVI-SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGT 140
++ + I++ LN G+ Q V+I SGL + + LA + + + LYW D+ +IEVAN +G
Sbjct: 807 LALDVIQRLCLN--GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGD 864
Query: 141 SRKVLFWQD-LDQPRAIALDPAHGYMYWTDWGET-PRIERAGMDGSTRKIIVDSDIYWPN 198
R + LD+PRA+ L P G M+WTDWG+ P I R+ MDGS +V D+ WPN
Sbjct: 865 FRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPN 924
Query: 199 GLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTR 258
G+++D +Q +YW DA L I R G R +++ +L HP+A+ + + +YW DW
Sbjct: 925 GISVD--DQWIYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQL 981
Query: 259 SIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCL------- 311
SI +K +G + + + + L MD+++ + + + CS LCL
Sbjct: 982 SIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRP---CSLLCLPKANNSR 1038
Query: 312 -----------LSPSEPFYTCACPTGVQLQDNGRTC 336
+ PS C CP G QL++N TC
Sbjct: 1039 SCRCPEDVSSSVLPSGDL-MCDCPQGYQLKNN--TC 1071
Score = 167 bits (423), Expect = 8e-41
Identities = 107/316 (33%), Positives = 168/316 (53%), Gaps = 18/316 (5%)
Query: 338 AGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAI 397
A E +L A R + R L + + L +R A+A+D+D +YW+D + I
Sbjct: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLT--GLRAAVALDFDYEHNCLYWSDLALDVI 812
Query: 398 RRAYLDGS-GAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSE 456
+R L+GS G + ++N+ + + +A + +++ LYW D G +IEV +G R +V+
Sbjct: 813 QRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNS 872
Query: 457 D-LDEPRAIALHPVMGLMYWTDWGE-NPKIECANLDGQERRVLVNASLGWPNGLALDLQE 514
LD PRA+ L P G+M+WTDWG+ P I +N+DG LV+ + WPNG+++D Q
Sbjct: 873 SVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQ- 931
Query: 515 GKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKV 574
+YW DA + IE I G +R +L D LPH + + + IYW DW + SI R K
Sbjct: 932 -WIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKY 989
Query: 575 KASR-DVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATR-CGCPIGLE 632
S+ +++ +QL LM +K K G+N C R CS LC + +R C CP
Sbjct: 990 SGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCP---- 1043
Query: 633 LLSDMKTCIVPEAFLV 648
D+ + ++P L+
Sbjct: 1044 --EDVSSSVLPSGDLM 1057
Score = 162 bits (409), Expect = 3e-39
Identities = 126/451 (27%), Positives = 200/451 (44%), Gaps = 45/451 (9%)
Query: 947 FLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYW----VDGRQNIKR 1002
F+L++ + +I R D LPL GLR A+D+D +YW +D Q +
Sbjct: 760 FILYAVRKSIYRY--DLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
Query: 1003 AKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGE-AMGVV 1061
G + + + L + L+ + S+ L+W I V G+ + +V
Sbjct: 818 NGSTGQEVIINSGLETVEA-------LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870
Query: 1062 LRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDN 1121
D+PRA+V+ + G +++T+ D I R+ +DG+ L + + P + VD+
Sbjct: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDD 930
Query: 1122 TLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVE 1181
++W DA L+ IE SG R + D N+ P + + +YW D Q I R
Sbjct: 931 QW--IYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFRAS 987
Query: 1182 KTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
K +G + + ++ L + + + ++ C CS +C+ K + + C CP
Sbjct: 988 KYSGSQMEILANQLTGLMDMKIFYKG--KNTGSNACVPRP--CSLLCLPKANNSRSCRCP 1043
Query: 1242 VHL---VLLQNLLTCGEPP--------------TCSPDQFACATGEIDCIPGAWRCDGFP 1284
+ VL L C P TC +Q+ C+ G +CI W CD
Sbjct: 1044 EDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNG--NCINSIWWCDFDN 1101
Query: 1285 ECDDQSDEEGCP--VCSA-AQFPCAR-GQCVDLRLRCDGEADCQDRSDEADCDA-ICLPN 1339
+C D SDE CP +C QF C G C+ L +CD E DC D SDE+ C+ C +
Sbjct: 1102 DCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSD 1161
Query: 1340 QFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
++ C+SG C+ CD DC D SDE C
Sbjct: 1162 EYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
Score = 127 bits (320), Expect = 7e-29
Identities = 130/468 (27%), Positives = 191/468 (40%), Gaps = 96/468 (20%)
Query: 975 GLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDI 1033
GL V+A+ ++PL + +YWVD G + I+ A DG F LT ++ +P L +
Sbjct: 830 GLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGD--FRLTIVNSSVLD--RPRALVLVP 885
Query: 1034 YSRTLFWTCEATNTINVHR--LSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAA 1091
+FWT ++R + G A ++ D P I V+ + ++Y+T+
Sbjct: 886 QEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQ--WIYWTDAYLEC- 942
Query: 1092 KIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD-ADLKRIESCDLSG------A 1144
IER G +R V+ L P A+ V +++W D + L + SG A
Sbjct: 943 -IERITFSGQQRSVILDN-LPHPYAIAVFKN--EIYWDDWSQLSIFRASKYSGSQMEILA 998
Query: 1145 NRLTL--------------EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKT---TGDK 1187
N+LT +A + +P L L K R + E V + +GD
Sbjct: 999 NQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANN--SRSCRCPEDVSSSVLPSGDL 1056
Query: 1188 RTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSH-ICIAK----------GDGTP 1236
G ++E + C R+ CS+ CI GD +
Sbjct: 1057 MCDCP------QGYQLKNNTCVKE--ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD 1108
Query: 1237 RCSCPVHLVLLQNLLTCGEPPTCSP---------------------------DQFACATG 1269
+CP + L C E TC P D++ C++G
Sbjct: 1109 ERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG 1168
Query: 1270 EIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLRLRCDGEADCQD 1325
CI +W CDG +C D SDE C C A+ F C G C+ R CDG+ DCQD
Sbjct: 1169 M--CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQD 1226
Query: 1326 RSDE--ADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE 1371
SDE +C+ C N FRC +G C+ + CD DC DGSDE CE
Sbjct: 1227 GSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCE 1272
Score = 107 bits (267), Expect = 9e-23
Identities = 58/143 (40%), Positives = 69/143 (48%), Gaps = 25/143 (17%)
Query: 1253 CGEPP----TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC------PVCSAA- 1301
C + P C F C G CI W+CDG +C D SDE C P CS
Sbjct: 1315 CSQDPEFHKVCDEFGFQCQNGV--CISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYF 1372
Query: 1302 QFPCARGQCVDLRLRCDGEADCQDRSDEADCD------------AICLPNQFRCASGQCV 1349
QF C G C+ R +CD E DC D SDE DC + CLPN +RC+SG CV
Sbjct: 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV 1432
Query: 1350 LIKQQCDSFPDCIDGSDELMCEI 1372
+ CD + DC DGSDE C +
Sbjct: 1433 MDTWVCDGYRDCADGSDEEACPL 1455
Score = 103 bits (257), Expect = 1e-21
Identities = 50/136 (36%), Positives = 72/136 (52%), Gaps = 23/136 (16%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---------------CSA 1300
P TC P+ + C++G C+ W CDG+ +C D SDEE CP+ C
Sbjct: 1416 PSTCLPNYYRCSSGT--CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDR 1473
Query: 1301 AQFPCARGQ-CVDLRLRCDGEADCQDRSDEADCDA----ICLPNQFRCASGQ-CVLIKQQ 1354
+F C + + C+ RCDG DCQD DEA+C C+ +F+C G+ C+++ ++
Sbjct: 1474 FEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSER 1533
Query: 1355 CDSFPDCIDGSDELMC 1370
CD F DC D SDE C
Sbjct: 1534 CDGFLDCSDESDEKAC 1549
Score = 82.8 bits (203), Expect = 2e-15
Identities = 46/115 (40%), Positives = 54/115 (46%), Gaps = 9/115 (7%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQ---FPCARGQCVDLR 1314
TC F C G CIP W CDG +C D SDE+ PV + F C G C+
Sbjct: 1198 TCEASNFQCRNGH--CIPQRWACDGDTDCQDGSDED--PVNCEKKCNGFRCPNGTCIPSS 1253
Query: 1315 LRCDGEADCQDRSDEADCDAICLP-NQFRCAS-GQCVLIKQQCDSFPDCIDGSDE 1367
CDG DC D SDE C+ +C F C + QC+ CD C DGSDE
Sbjct: 1254 KHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
Score = 78.6 bits (192), Expect = 5e-14
Identities = 49/132 (37%), Positives = 65/132 (49%), Gaps = 17/132 (12%)
Query: 1255 EPPTCSP--DQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-PVCSA-AQFPCA-RGQ 1309
+P C + F C G CIP + CDG +C D SDE+ C P+C+ F C R Q
Sbjct: 1231 DPVNCEKKCNGFRCPNGT--CIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQ 1288
Query: 1310 CVDLRLRCDGEADCQDRSDE----ADCDA------ICLPNQFRCASGQCVLIKQQCDSFP 1359
C+ + CDG C+D SDE A C +C F+C +G C+ + +CD
Sbjct: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
Query: 1360 DCIDGSDELMCE 1371
DC D SDE CE
Sbjct: 1349 DCGDYSDEANCE 1360
Score = 69.3 bits (168), Expect = 3e-11
Identities = 41/109 (37%), Positives = 51/109 (46%), Gaps = 14/109 (12%)
Query: 1233 DGTPRCSCPVHLVLLQNLLTCGEPPT---CSPDQFACATGEIDCIPGAWRCDGFPECDDQ 1289
DG+ +CP LL N+ P C +F C + CIP RCDG +C D
Sbjct: 1446 DGSDEEACP----LLANVTAASTPTQLGRCDRFEFECHQPKT-CIPNWKRCDGHQDCQDG 1500
Query: 1290 SDEEGCP-----VCSAAQFPCARGQ-CVDLRLRCDGEADCQDRSDEADC 1332
DE CP C + +F C G+ C+ L RCDG DC D SDE C
Sbjct: 1501 RDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 61.6 bits (148), Expect = 6e-09
Identities = 85/351 (24%), Positives = 143/351 (40%), Gaps = 34/351 (9%)
Query: 1029 LSIDIYSRTLFWTCEATNTINVHRLSGEA-MGVVLRGDRDKPRAIVVNAERGYLYFTNMQ 1087
L D L+W+ A + I L+G V++ + A+ LY+ +
Sbjct: 793 LDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAG 852
Query: 1088 DRAAKIERAALDGTEREVLFTTGLI-RPVALVVDNTLGKLFWVD-ADLKR-IESCDLSGA 1144
+ KIE A DG R + + ++ RP ALV+ G +FW D DLK I ++ G+
Sbjct: 853 FK--KIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGS 910
Query: 1145 NRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAV 1204
L ++ P G+++ + +YW D + IER+ +G +R+ I + H I
Sbjct: 911 AAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERIT-FSGQQRSVILDNLPHPYAIAVF 969
Query: 1205 E-EVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQ 1263
+ E+ +++S R +K G+ L L ++ +
Sbjct: 970 KNEIYWDDWSQLSIFR---------ASKYSGSQMEILANQLTGLMDMKIFYKGKN----- 1015
Query: 1264 FACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV-CSAAQFPCARGQCVDLRLRCDGEAD 1322
TG C+P P+ ++ S CP S++ P DL C
Sbjct: 1016 ----TGSNACVPRPCSLLCLPKANN-SRSCRCPEDVSSSVLPSG-----DLMCDCPQGYQ 1065
Query: 1323 CQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEIT 1373
++ + + + CL NQ+RC++G C+ CD DC D SDE C T
Sbjct: 1066 LKNNTCVKE-ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTT 1115
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 191 bits (486), Expect = 4e-48
Identities = 104/263 (39%), Positives = 143/263 (54%), Gaps = 18/263 (6%)
Query: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDT 435
I + +D ++ VYWTD +I RA L G T++ ++ P+GIAVD + RN++WTD+
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDS 1040
Query: 436 GTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQER 494
DRIEV +L+GT R++L DL PR I V G +YWTDW +NPKIE + +DG R
Sbjct: 1041 NLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNR 1100
Query: 495 RVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLL 554
R+LV LG PNGL D +L W DA T++ E +N RR LE L + F T
Sbjct: 1101 RILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSY 1159
Query: 555 GDFIYWTDWQRRSIERVHKVKASRDVIIDQLPD---------LMGLKAVNVAKVVGTNPC 605
G +Y+TDW+ S+ + D+ I + D L G+ G N C
Sbjct: 1160 GKNLYFTDWKMNSV-------VALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC 1212
Query: 606 ADRNGGCSHLCFFTPHATRCGCP 628
+ NGGC+HLC TP + C CP
Sbjct: 1213 SVNNGGCTHLCLATPGSRTCRCP 1235
Score = 188 bits (477), Expect = 4e-47
Identities = 107/293 (36%), Positives = 146/293 (49%), Gaps = 7/293 (2%)
Query: 643 PEAFLVFTSRAAIHRISLETNN----NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKT 698
P L+F I R+ LE N A K L FD + +YWTD++ +
Sbjct: 942 PGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS 1001
Query: 699 ISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWR 758
I RA ++G ++ L PEG+AVD +G+N++W D+ +RIEVA+LDG R+VL
Sbjct: 1002 IGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFET 1061
Query: 759 DLDNPRSLALDPTKGYIYWTEWG-GKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDYADQ 816
DL NPR + D +G +YWT+W P+I ++MDGTN LV D +G N LT D
Sbjct: 1062 DLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDDLGLPNGLTFDAFSS 1121
Query: 817 RLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSG 876
+L W D TN E N R + L +PF +T Y +Y+TDW ++S+ D
Sbjct: 1122 QLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAIS 1181
Query: 877 RNRTLIQGHLDF-VMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGC 928
+ Q H + I S G N C NNG C LCLA PG C C
Sbjct: 1182 KETDAFQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCTHLCLATPGSRTCRC 1234
Score = 187 bits (476), Expect = 5e-47
Identities = 120/315 (38%), Positives = 163/315 (51%), Gaps = 23/315 (7%)
Query: 24 GCPAPAAASPL-----LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAV----DFQFSK 74
G P A PL LLFA + + G + T + L A V F
Sbjct: 930 GPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCVD 989
Query: 75 GAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEV 134
VYWTD++E +I + L+ G ++ L SP+G+A D +G+ ++WTDS +RIEV
Sbjct: 990 KMVYWTDITEPSIGRASLH--GGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDRIEV 1047
Query: 135 ANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSD 193
A L+GT R+VLF DL PR I D G +YWTDW + P+IE + MDG+ R+I+V D
Sbjct: 1048 AKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILVQDD 1107
Query: 194 IYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWT 253
+ PNGLT D +L W DA + N R+K +EG L +PFA+T G LY+T
Sbjct: 1108 LGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG-LQYPFAVTSYGKNLYFT 1166
Query: 254 DWQTRSI----HACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHL 309
DW+ S+ A +K T + + LY LSQ P H C +NGGC+HL
Sbjct: 1167 DWKMNSVVALDLAISKETDAFQPHKQTRLYG--ITTALSQ--CPQGHNYCSVNNGGCTHL 1222
Query: 310 CLLSPSEPFYTCACP 324
CL +P TC CP
Sbjct: 1223 CLATPGS--RTCRCP 1235
Score = 117 bits (294), Expect = 7e-26
Identities = 95/317 (29%), Positives = 141/317 (44%), Gaps = 40/317 (12%)
Query: 943 PPTTFLLFSQKSAISRMIPDDQHSPDLILPLHG--LRNVKA-------------IDYDPL 987
PP T LLF+Q I R LPL G +R +A + +D +
Sbjct: 941 PPGTHLLFAQTGKIER------------LPLEGNTMRKTEAKAFLHVPAKVIIGLAFDCV 988
Query: 988 DKFIYWVDGRQ-NIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATN 1046
DK +YW D + +I RA G +P + G P +++D R +FWT +
Sbjct: 989 DKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGS-----PEGIAVDHLGRNIFWTDSNLD 1043
Query: 1047 TINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVL 1106
I V +L G V+ D PR IV ++ RG LY+T+ KIE + +DGT R +L
Sbjct: 1044 RIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRIL 1103
Query: 1107 FTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLS-GANRLTLEDANIVQPLGLTILGK 1165
L P L D +L WVDA R E + S + R LE + P +T GK
Sbjct: 1104 VQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALE--GLQYPFAVTSYGK 1161
Query: 1166 HLYWIDRQQQMIERVEKTTGDKRTRIQ-GRVAHLTGIHAVEEVSLEEFSAHPCARDNGGC 1224
+LY+ D + + ++ + Q + L GI +S + C+ +NGGC
Sbjct: 1162 NLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGI--TTALSQCPQGHNYCSVNNGGC 1219
Query: 1225 SHICIAKGDGTPRCSCP 1241
+H+C+A G+ C CP
Sbjct: 1220 THLCLAT-PGSRTCRCP 1235
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 178 bits (451), Expect = 4e-44
Identities = 95/223 (42%), Positives = 135/223 (60%), Gaps = 5/223 (2%)
Query: 376 IAIDYDPLEGYVYWTDDEVRAIRRAYLD-GSGAQTLVNTEINDPDGIAVDWVARNLYWTD 434
+ IDYD E VYWTD R I RA L+ G+ +T+VN+ + P+G+A+D + R +YWTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 435 TGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWG-ENPKIECANLDGQE 493
+ D+IE L+G+ RK+L DL PRAIA+ P+ G +YWTDW E PKIE ++LDG+
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
Query: 494 RRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTL 553
RR+L+N +G PNGL D L W DA T K+E DGT RR ++++ L + F
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRR-VIQNNLKYPFSIVS 1323
Query: 554 LGDFIYWTDWQRRSIERV--HKVKASRDVIIDQLPDLMGLKAV 594
D Y TDW+R + V H + + + + +Q L G+ AV
Sbjct: 1324 YADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
Score = 176 bits (447), Expect = 1e-43
Identities = 95/253 (37%), Positives = 146/253 (57%), Gaps = 7/253 (2%)
Query: 28 PAAASPLLLFANRRDVRLVDAGGVKLES----TIVVSGLEDAAAVDFQFSKGAVYWTDVS 83
P + LL+ + + + G +L+ T++ +D+ + VYWTDV+
Sbjct: 1103 PPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVA 1162
Query: 84 EEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRK 143
I + L + GA + +V SGL+SP+GLA D + + +YWTDS ++IE A L+G+ RK
Sbjct: 1163 GRTISRAGL-ELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERK 1221
Query: 144 VLFWQDLDQPRAIALDPAHGYMYWTDWG-ETPRIERAGMDGSTRKIIVDSDIYWPNGLTI 202
VLF+ DL PRAIA+DP G +YWTDW E P+IE + +DG R+I++++DI PNGLT
Sbjct: 1222 VLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTF 1281
Query: 203 DLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHA 262
D + L WADA + DG+ R +V++ +L +PF++ D Y TDW+ + +
Sbjct: 1282 DPFSKLLCWADAGTKKLECTLPDGTGR-RVIQNNLKYPFSIVSYADHFYHTDWRRDGVVS 1340
Query: 263 CNKRTGGKRKEIL 275
NK +G E L
Sbjct: 1341 VNKHSGQFTDEYL 1353
Score = 155 bits (391), Expect = 4e-37
Identities = 79/201 (39%), Positives = 122/201 (60%), Gaps = 3/201 (1%)
Query: 680 LDFDVSNNHIYWTDVSLKTISRAFMN-GSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTG 738
+D+D +YWTDV+ +TISRA + G+ E +V GL PEG+A+D + + +YW D+
Sbjct: 1147 IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSV 1206
Query: 739 TNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGK-PRIVRAFMDGTNCM 797
++IE A LDG R+VL + DL NPR++A+DP +G +YWT+W + P+I + +DG N
Sbjct: 1207 LDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRR 1266
Query: 798 TLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
L++ +G N LT D + L W D T +E + G R VI ++L +PF + Y+D
Sbjct: 1267 ILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVSYAD 1326
Query: 857 YIYWTDWNLHSIERADKTSGR 877
+ Y TDW + +K SG+
Sbjct: 1327 HFYHTDWRRDGVVSVNKHSGQ 1347
Score = 105 bits (263), Expect = 3e-22
Identities = 81/272 (29%), Positives = 125/272 (45%), Gaps = 16/272 (5%)
Query: 942 SPPT--TFLLFSQKSAISRMIPD----DQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVD 995
+PP+ TFLL++Q I + + + + +L LHG + IDYD ++ +YW D
Sbjct: 1102 TPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHG-SIIVGIDYDCRERMVYWTD 1160
Query: 996 --GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRL 1053
GR + + G +P + + P L+ID RT++WT + I L
Sbjct: 1161 VAGRTISRAGLELGAEPETIVNSGL-----ISPEGLAIDHIRRTMYWTDSVLDKIESALL 1215
Query: 1054 SGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIR 1113
G V+ D PRAI V+ RG LY+T+ A KIE ++LDG R +L T +
Sbjct: 1216 DGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGL 1275
Query: 1114 PVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQ 1173
P L D L W DA K++E G R +++ N+ P + H Y D +
Sbjct: 1276 PNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQN-NLKYPFSIVSYADHFYHTDWR 1334
Query: 1174 QQMIERVEKTTGDKRTR-IQGRVAHLTGIHAV 1204
+ + V K +G + + +HL GI AV
Sbjct: 1335 RDGVVSVNKHSGQFTDEYLPEQRSHLYGITAV 1366
Score = 70.9 bits (172), Expect = 1e-11
Identities = 43/129 (33%), Positives = 66/129 (51%), Gaps = 5/129 (3%)
Query: 366 VLQVDDIRHAIAIDYDPLEGYVYWTD--DEVRAIRRAYLDGSGAQTLVNTEINDPDGIAV 423
VL D+ + AI DP+ G +YWTD E I + LDG + L+NT+I P+G+
Sbjct: 1222 VLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTF 1281
Query: 424 DWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPK 483
D ++ L W D GT ++E T +GT R++ + +L P +I + Y TDW +
Sbjct: 1282 DPFSKLLCWADAGTKKLECTLPDGTGRRV-IQNNLKYPFSIVSY--ADHFYHTDWRRDGV 1338
Query: 484 IECANLDGQ 492
+ GQ
Sbjct: 1339 VSVNKHSGQ 1347
Score = 32.7 bits (73), Expect = 2.9
Identities = 15/46 (32%), Positives = 22/46 (47%), Gaps = 5/46 (10%)
Query: 904 NDCMHNNGQCG--QLCLAIPGGHRCGCASHYTLDPSSRNC---SPP 944
N+C +CG +C+ +PG +RC C S Y C +PP
Sbjct: 803 NECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPP 848
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 110 bits (276), Expect = 8e-24
Identities = 57/139 (41%), Positives = 72/139 (51%), Gaps = 14/139 (10%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC---PVCSAAQFPCARGQCVD 1312
P C P + AC G CIP + CDG +C+D SDE C P C +FPC G C
Sbjct: 282 PLPCGPQEAACRNGH--CIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCAL 339
Query: 1313 LRLRCDGEADCQDRSDEADC-----DAICLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSD 1366
RCDG+ DC+DR+DEA+C + +C P QFRC S C+ CD DC D SD
Sbjct: 340 KLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSD 399
Query: 1367 ELMC---EITKPPSDDSPA 1382
E C ++ PP + A
Sbjct: 400 EFGCMPPQVVTPPRESIQA 418
Score = 85.5 bits (210), Expect = 4e-16
Identities = 39/89 (43%), Positives = 48/89 (53%), Gaps = 9/89 (10%)
Query: 1251 LTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP------VCSAAQFP 1304
L CG PP C P++F C G C WRCDG +C+D++DE CP VC QF
Sbjct: 317 LDCGPPPPCEPNEFPCGNGH--CALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFR 374
Query: 1305 C-ARGQCVDLRLRCDGEADCQDRSDEADC 1332
C + C+ CD E+DC DRSDE C
Sbjct: 375 CVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 81.6 bits (200), Expect = 5e-15
Identities = 50/170 (29%), Positives = 66/170 (38%), Gaps = 51/170 (30%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PV---------------- 1297
P C+ +FAC + +C+ +RCD P+C D SDE C PV
Sbjct: 196 PRACTEAEFACHSYN-ECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSL 254
Query: 1298 ------------------------------CSAAQFPCARGQCVDLRLRCDGEADCQDRS 1327
C + C G C+ CDG+ DC+D S
Sbjct: 255 PPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGS 314
Query: 1328 DEADC--DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKP 1375
DE DC C PN+F C +G C L +CD DC D +DE C +P
Sbjct: 315 DELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRP 364
Score = 40.4 bits (93), Expect = 0.014
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 1336 CLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHS 1384
C +F C S +CV ++ +CD PDC D SDEL CE +P SP S
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCE--EPVLGISPTFS 246
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 108 bits (270), Expect = 4e-23
Identities = 54/124 (43%), Positives = 70/124 (56%), Gaps = 10/124 (8%)
Query: 1261 PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP----VCSAAQFPCARG-QCVDLRL 1315
P F C+ G CIPGAW+CDG P+C D+SDE+ CP C FPCA G C+ R
Sbjct: 32 PGNFMCSNGR--CIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRF 89
Query: 1316 RCDGEADCQDRSDEADCDA---ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
RC+G DC D SDE +C A +C ++ C +G C+ CD +C D SDE CE
Sbjct: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
Query: 1373 TKPP 1376
++ P
Sbjct: 150 SQEP 153
Score = 43.5 bits (101), Expect = 0.002
Identities = 17/38 (44%), Positives = 22/38 (57%)
Query: 1337 LPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
+P F C++G+C+ QCD PDC D SDE C K
Sbjct: 31 IPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAK 68
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 102 bits (253), Expect = 4e-21
Identities = 50/110 (45%), Positives = 67/110 (60%), Gaps = 6/110 (5%)
Query: 1262 DQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEA 1321
+ F CA+G CIPG +C+G+ +CDD SDE C CS F C G+C++ L CDG
Sbjct: 273 ENFLCASGI--CIPGKLQCNGYNDCDDWSDEAHCN-CSENLFHCHTGKCLNYSLVCDGYD 329
Query: 1322 DCQDRSDEADCDAICLP-NQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
DC D SDE +CD C P + RC G+C+ ++ CD DC+D SDE+ C
Sbjct: 330 DCGDLSDEQNCD--CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Score = 94.0 bits (232), Expect = 1e-18
Identities = 44/114 (38%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCD 1318
CS + F C TG+ C+ + CDG+ +C D SDE+ C + C G+C+ + CD
Sbjct: 306 CSENLFHCHTGK--CLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCD 363
Query: 1319 GEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
G+ DC D+SDE +C C +GQC+ QCD DC DGSDE C +
Sbjct: 364 GDHDCVDKSDEVNCSCHS-QGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSV 416
Score = 88.6 bits (218), Expect = 4e-17
Identities = 45/113 (39%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPC-ARGQCVDLRLRC 1317
CSP F C +G+ C+ + RCDG +CDD SDEE C + C + QC+ + C
Sbjct: 580 CSPSHFKCRSGQ--CVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVIC 637
Query: 1318 DGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
DG DC D DE +C + C ++ CA+ CV CD DC D SDE C
Sbjct: 638 DGFPDCPDYMDEKNC-SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 75.9 bits (185), Expect = 3e-13
Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 1262 DQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEA 1321
D + C + + C+ CDGFP+C D DE+ C C + CA CV L CDGEA
Sbjct: 620 DLWECPSNK-QCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEA 678
Query: 1322 DCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
DC D SDE DC + + S +++ + C DG E++ ++
Sbjct: 679 DCSDSSDEWDCVTLSI----NVNSSSFLMVHRAATEHHVCADGWQEILSQL 725
Score = 72.0 bits (175), Expect = 4e-12
Identities = 36/95 (37%), Positives = 46/95 (48%), Gaps = 6/95 (6%)
Query: 1259 CSPD-QFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRC 1317
C+P + C G CI W CDG +C D+SDE C S C GQC+ +C
Sbjct: 342 CNPTTEHRCGDGR--CIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQC 399
Query: 1318 DGEADCQDRSDEADCDAI---CLPNQFRCASGQCV 1349
DG+ DC+D SDE +C I C RC C+
Sbjct: 400 DGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCL 434
Score = 71.2 bits (173), Expect = 7e-12
Identities = 43/114 (37%), Positives = 54/114 (47%), Gaps = 13/114 (11%)
Query: 1280 CDGFPECDDQSDEEGCPV-------CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1332
C FPE + SD + C + CS + F C GQCV RCDG+ADC D SDE +C
Sbjct: 557 CSQFPE--ENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
Query: 1333 DAICLPNQ-FRCASG-QCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHS 1384
C + C S QC+ CD FPDC D DE C + + H+
Sbjct: 615 G--CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHA 666
Score = 38.1 bits (87), Expect = 0.069
Identities = 34/117 (29%), Positives = 48/117 (41%), Gaps = 29/117 (24%)
Query: 1283 FPECD-DQSDEEGC----PVCSAAQFPC------ARGQCVDLRLRCDGEADCQDRSDEAD 1331
FPEC D D G C AA+ C D LRC + +++++ ++
Sbjct: 196 FPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDF-LRC---SQFRNQTESSN 251
Query: 1332 CDAICLPNQ--------------FRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
IC Q F CASG C+ K QC+ + DC D SDE C ++
Sbjct: 252 VSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSE 308
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 97.8 bits (242), Expect = 7e-20
Identities = 51/136 (37%), Positives = 67/136 (49%), Gaps = 12/136 (8%)
Query: 1265 ACATGEI------DCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCVDLRLR 1316
ACA GE C+P W CD +C D SDEEGC P C Q C+ G C+ L L
Sbjct: 1375 ACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALL 1434
Query: 1317 CDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC--EITK 1374
CD + DC D +DE C CA G+C+ CD PDC+D +DE C ++T
Sbjct: 1435 CDRQDDCGDGTDEPSYP--CPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTC 1492
Query: 1375 PPSDDSPAHSSAIGPV 1390
P + S + +G +
Sbjct: 1493 VPGEVSCVDGTCLGAI 1508
Score = 84.7 bits (208), Expect = 6e-16
Identities = 48/126 (38%), Positives = 59/126 (46%), Gaps = 16/126 (12%)
Query: 1250 LLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP-VCSAAQFPCARG 1308
L + P C P +F C +GE C P WRCD +C D SDE GC C+ PCARG
Sbjct: 1556 LASASPAPPCGPFEFRCGSGE--CTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARG 1613
Query: 1309 -QCVDLRLRCDGEADCQDRSDEAD-----CDAICLPN-------QFRCASGQCVLIKQQC 1355
CV CDG C D SDE A+ PN ++ C +G C+ + C
Sbjct: 1614 PHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVC 1673
Query: 1356 DSFPDC 1361
D PDC
Sbjct: 1674 DGQPDC 1679
Score = 80.1 bits (196), Expect = 2e-14
Identities = 62/197 (31%), Positives = 74/197 (37%), Gaps = 50/197 (25%)
Query: 1220 DNGGCSHICIAKGDGTPRCS---CPVHLVLLQNLLTCG----EPP-TCSPDQFACATGEI 1271
D GC+ G+G CS C +L CG EP C ACA G
Sbjct: 1407 DEEGCA--APGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGR- 1463
Query: 1272 DCIPGAWRCDGFPECDDQSDEEGC---PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSD 1328
C+P A CDG P+C D +DEE C C + C G C+ CDG DC D +D
Sbjct: 1464 -CLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGAD 1522
Query: 1329 E-----------------------------------ADCDAICLPNQFRCASGQCVLIKQ 1353
E A C P +FRC SG+C
Sbjct: 1523 EGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGW 1582
Query: 1354 QCDSFPDCIDGSDELMC 1370
+CD DC DGSDE C
Sbjct: 1583 RCDQEEDCADGSDERGC 1599
Score = 79.7 bits (195), Expect = 2e-14
Identities = 59/194 (30%), Positives = 68/194 (35%), Gaps = 58/194 (29%)
Query: 1232 GDGT--PRCSCPVHLVL------LQNLLTCGEPPTCSP--------DQFACATGEIDCIP 1275
GDGT P CP L+ L L C P C Q C GE+ C+
Sbjct: 1442 GDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVD 1501
Query: 1276 GAWR-----CDGFPECDDQSDE------------------------------------EG 1294
G CDG +C D +DE
Sbjct: 1502 GTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASP 1561
Query: 1295 CPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASG-QCVLIKQ 1353
P C +F C G+C RCD E DC D SDE C C P+ CA G CV +Q
Sbjct: 1562 APPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQ 1621
Query: 1354 QCDSFPDCIDGSDE 1367
CD C DGSDE
Sbjct: 1622 LCDGVRQCPDGSDE 1635
Score = 62.0 bits (149), Expect = 4e-09
Identities = 35/108 (32%), Positives = 43/108 (39%), Gaps = 35/108 (32%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCD------------------------ 1333
C Q PC CV+ CDG DC D SDE C
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 1334 -----------AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
A+C P+Q C SG+C+ +++CD PDC DGSDE C
Sbjct: 2451 TMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 54.7 bits (130), Expect = 7e-07
Identities = 35/120 (29%), Positives = 43/120 (35%), Gaps = 39/120 (32%)
Query: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP------------------- 1296
P C P Q C + C+ A CDG +C D SDE C
Sbjct: 2388 PVQCGPGQTPCEV--LGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTV 2445
Query: 1297 -----------------VCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC-DAICLP 1338
+CS +Q C G+C+ RCD DCQD SDE C D + P
Sbjct: 2446 PFMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAP 2505
Score = 42.0 bits (97), Expect = 0.005
Identities = 23/52 (44%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 1335 ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSA 1386
+C RCASG+CVL CD DC DGSDE C + P HS+A
Sbjct: 2233 LCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLL--PEGTGRFHSTA 2282
Score = 41.2 bits (95), Expect = 0.008
Identities = 47/167 (28%), Positives = 60/167 (35%), Gaps = 14/167 (8%)
Query: 1296 PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLP---NQFRCASGQCVLIK 1352
P+C CA G+CV CDG DC+D SDE C + LP +F + L
Sbjct: 2232 PLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC--VLLPEGTGRFHSTAKTLALSS 2289
Query: 1353 QQCDSFPDCIDGSDELMCEITK-PPSDDSPAHSSAIGPVIGIILSLFVMGG--VYFVCQR 1409
Q + E + E PP +SP + PV S G V V
Sbjct: 2290 AQPGQL---LHWPREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMVTTT 2346
Query: 1410 VVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQ--HGPFTGIACG 1454
+ Q A P PH P+ P G GPF + CG
Sbjct: 2347 PIPQMEARTLPPGMAAVTVVPPH-PVTPATPAGQSVAPGPFPPVQCG 2392
Score = 40.4 bits (93), Expect = 0.014
Identities = 23/50 (46%), Positives = 27/50 (54%), Gaps = 6/50 (12%)
Query: 1250 LLTC--GEPPT--CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC 1295
LL C G PP C CA+GE C+ CDG +C+D SDEEGC
Sbjct: 2221 LLGCEPGSPPAPLCPGVGLRCASGE--CVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 31.6 bits (70), Expect = 6.5
Identities = 14/41 (34%), Positives = 20/41 (48%), Gaps = 7/41 (17%)
Query: 1213 SAHPCARDNGGCSHICIAKGDG-------TPRCSCPVHLVL 1246
SA C ++ G C +C+ +G G P C+CP L L
Sbjct: 2894 SAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFL 2934
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 96.7 bits (239), Expect = 2e-19
Identities = 49/110 (44%), Positives = 57/110 (51%), Gaps = 4/110 (3%)
Query: 1261 PDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGE 1320
P QF C TG CI RCDG+ +C D SDE C + QF C C L CD
Sbjct: 454 PGQFTCRTGR--CIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSV 511
Query: 1321 ADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
DC D SDE C C FRC++G+C+ QQC+ DC DGSDE C
Sbjct: 512 NDCGDNSDEQGCS--CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Score = 92.0 bits (227), Expect = 4e-18
Identities = 49/121 (40%), Positives = 64/121 (52%), Gaps = 11/121 (9%)
Query: 1259 CSPD---QFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRL 1315
CS D QF C C P W CD +C D SDE+GC C A F C+ G+C+
Sbjct: 486 CSCDAGHQFTCKNKF--CKPLFWVCDSVNDCGDNSDEQGCS-CPAQTFRCSNGKCLSKSQ 542
Query: 1316 RCDGEADCQDRSDEADCDAI----CLPNQFRCASGQCVLI-KQQCDSFPDCIDGSDELMC 1370
+C+G+ DC D SDEA C + C + +RC +G C+ +CD DC DGSDE C
Sbjct: 543 QCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Query: 1371 E 1371
+
Sbjct: 603 D 603
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 92.4 bits (228), Expect = 3e-18
Identities = 49/128 (38%), Positives = 65/128 (50%), Gaps = 10/128 (7%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV------CSAAQFPCARG 1308
+P C DQF+C + C+P + +CDG +C D SDE CP+ CS +FPC+
Sbjct: 1334 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD 1392
Query: 1309 QCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFRCA-SGQCVLIKQQCDSFPDCIDGS- 1365
+C+ L CDG DC DE C + C CA S C+ Q+CD F DC+D
Sbjct: 1393 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452
Query: 1366 DELMCEIT 1373
DE C T
Sbjct: 1453 DESSCSDT 1460
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 10/91 (10%)
Query: 1336 CLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP--VIG 1392
C +QF C + QCV + +CD DCIDGSDE+ C + P P S+ P
Sbjct: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTP----PLCSNMEFPCSTDE 1393
Query: 1393 IILSLFVMGGV---YFVCQRVVCQRYAGANG 1420
I SL + GV +F ++C + +NG
Sbjct: 1394 CIPSLLLCDGVPDCHFNEDELICSNKSCSNG 1424
Score = 37.4 bits (85), Expect = 0.12
Identities = 15/36 (41%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Query: 1298 CSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDEADC 1332
C+ +F C + G C++ +CD + DC D+SDEA C
Sbjct: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
Score = 35.4 bits (80), Expect = 0.45
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 1336 CLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMC 1370
C N+F C S G C+ Q+CD DC D SDE C
Sbjct: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
Score = 35.4 bits (80), Expect = 0.45
Identities = 16/44 (36%), Positives = 22/44 (50%)
Query: 1324 QDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
QD S + C ++F CA+ C+ + CD DC D SDE
Sbjct: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
Score = 35.4 bits (80), Expect = 0.45
Identities = 24/87 (27%), Positives = 33/87 (37%), Gaps = 17/87 (19%)
Query: 1293 EGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIK 1352
E CP F C +C+ L CD + DC RSDEA C + +G C
Sbjct: 1117 ELCP--EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC------AHYTSTTGSCNF-- 1166
Query: 1353 QQCDSFPDCIDGSDELMCEITKPPSDD 1379
+ G+ C +T+ DD
Sbjct: 1167 -------ETSSGNWTTACSLTQDSEDD 1186
Score = 34.3 bits (77), Expect = 1.0
Identities = 35/154 (22%), Positives = 60/154 (38%), Gaps = 27/154 (17%)
Query: 1162 ILGKHLY--------WIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFS 1213
+ GK +Y W D + Q++ ++ G++ R ++ + E S+ +
Sbjct: 314 MFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGF 373
Query: 1214 AHPCARDNGGCSHICIAKGD------GTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACA 1267
A D+ + G+ P S PV L P C+ ++F C
Sbjct: 374 TGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTL----------PPHNCTDNEFICR 423
Query: 1268 TGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCS 1299
+ + CI +CD +C D+SDE C VCS
Sbjct: 424 S-DGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
Score = 34.3 bits (77), Expect = 1.0
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 16/121 (13%)
Query: 1287 DDQSDEEGCPV------CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQ 1340
DD S ++ P+ C+ +F CA C+ CD DC D SDE IC
Sbjct: 612 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET--TFIC---- 665
Query: 1341 FRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIG---IILSL 1397
R +SG+C C + + D + + P + PA +G G I SL
Sbjct: 666 -RTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSL 724
Query: 1398 F 1398
F
Sbjct: 725 F 725
Score = 31.2 bits (69), Expect = 8.5
Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 10/91 (10%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDS 1357
C C G+C L C+ +C D + E C + C G C Q D+
Sbjct: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSC-----TFEKGWCGWQNSQADN 902
Query: 1358 FPDCID-GSDELMCEITKPPSDDSPAHSSAI 1387
F + GS + + +PP D + + +AI
Sbjct: 903 FDWVLGVGSHQSL----RPPKDHTLGNENAI 929
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 92.4 bits (228), Expect = 3e-18
Identities = 49/128 (38%), Positives = 65/128 (50%), Gaps = 10/128 (7%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV------CSAAQFPCARG 1308
+P C DQF+C + C+P + +CDG +C D SDE CP+ CS +FPC+
Sbjct: 1609 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD 1667
Query: 1309 QCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFRCA-SGQCVLIKQQCDSFPDCIDGS- 1365
+C+ L CDG DC DE C + C CA S C+ Q+CD F DC+D
Sbjct: 1668 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1727
Query: 1366 DELMCEIT 1373
DE C T
Sbjct: 1728 DESSCSDT 1735
Score = 44.3 bits (103), Expect = 0.001
Identities = 17/33 (51%), Positives = 20/33 (60%)
Query: 1297 VCSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1329
+CSA +FPC GQC+ CD DC D SDE
Sbjct: 73 LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 10/91 (10%)
Query: 1336 CLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP--VIG 1392
C +QF C + QCV + +CD DCIDGSDE+ C + P P S+ P
Sbjct: 1613 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTP----PLCSNMEFPCSTDE 1668
Query: 1393 IILSLFVMGGV---YFVCQRVVCQRYAGANG 1420
I SL + GV +F ++C + +NG
Sbjct: 1669 CIPSLLLCDGVPDCHFNEDELICSNKSCSNG 1699
Score = 40.4 bits (93), Expect = 0.014
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 1335 ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
+C ++F C SGQC+ + CDS DC D SDE
Sbjct: 73 LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105
Score = 38.1 bits (87), Expect = 0.069
Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 17/87 (19%)
Query: 1293 EGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIK 1352
E CP F C +C+ L CD + DC DRSDEA C + +G C
Sbjct: 1392 ELCP--EITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC------AHYTSTTGSCNF-- 1441
Query: 1353 QQCDSFPDCIDGSDELMCEITKPPSDD 1379
+ G+ C +T+ DD
Sbjct: 1442 -------ETSSGNWTTACSLTQDSEDD 1461
Score = 37.4 bits (85), Expect = 0.12
Identities = 15/36 (41%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Query: 1298 CSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDEADC 1332
C+ +F C + G C++ +CD + DC D+SDEA C
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 36.2 bits (82), Expect = 0.26
Identities = 17/44 (38%), Positives = 25/44 (56%), Gaps = 5/44 (11%)
Query: 1253 CGEPPT---CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE 1293
CG+ + CS D+F C +G+ CI CD +C D+SDE+
Sbjct: 65 CGQTQSRKLCSADEFPCTSGQ--CIAKESVCDSRQDCSDESDED 106
Score = 35.4 bits (80), Expect = 0.45
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 1336 CLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMC 1370
C N+F C S G C+ Q+CD DC D SDE C
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.4 bits (80), Expect = 0.45
Identities = 16/44 (36%), Positives = 22/44 (50%)
Query: 1324 QDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
QD S + C ++F CA+ C+ + CD DC D SDE
Sbjct: 892 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 935
Score = 34.7 bits (78), Expect = 0.77
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 16/121 (13%)
Query: 1287 DDQSDEEGCPV------CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQ 1340
DD S ++ P+ C+ +F CA C+ CD DC D SDE IC
Sbjct: 887 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET--TFIC---- 940
Query: 1341 FRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIG---IILSL 1397
R +SG+C C + + D + + P + PA +G G I SL
Sbjct: 941 -RTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSL 999
Query: 1398 F 1398
F
Sbjct: 1000 F 1000
Score = 34.3 bits (77), Expect = 1.0
Identities = 35/154 (22%), Positives = 60/154 (38%), Gaps = 27/154 (17%)
Query: 1162 ILGKHLY--------WIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFS 1213
+ GK +Y W D + Q++ ++ G++ R ++ + E S+ +
Sbjct: 589 MFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGF 648
Query: 1214 AHPCARDNGGCSHICIAKGD------GTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACA 1267
A D+ + G+ P S PV L P C+ ++F C
Sbjct: 649 TGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTL----------PPHNCTDNEFICR 698
Query: 1268 TGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCS 1299
+ + CI +CD +C D+SDE C VCS
Sbjct: 699 S-DGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731
Score = 31.6 bits (70), Expect = 6.5
Identities = 19/61 (31%), Positives = 25/61 (40%), Gaps = 5/61 (8%)
Query: 1250 LLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQ 1309
LL+ GE P+ + CI CD P+C D+SDE C A + G
Sbjct: 1384 LLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC-----AHYTSTTGS 1438
Query: 1310 C 1310
C
Sbjct: 1439 C 1439
Score = 31.2 bits (69), Expect = 8.5
Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 10/91 (10%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDS 1357
C C G+C L C+ +C D + E C + C G C Q D+
Sbjct: 1123 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSC-----TFEKGWCGWQNSQADN 1177
Query: 1358 FPDCID-GSDELMCEITKPPSDDSPAHSSAI 1387
F + GS + + +PP D + + +AI
Sbjct: 1178 FDWVLGVGSHQSL----RPPKDHTLGNENAI 1204
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 92.4 bits (228), Expect = 3e-18
Identities = 49/128 (38%), Positives = 65/128 (50%), Gaps = 10/128 (7%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV------CSAAQFPCARG 1308
+P C DQF+C + C+P + +CDG +C D SDE CP+ CS +FPC+
Sbjct: 1609 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTD 1667
Query: 1309 QCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFRCA-SGQCVLIKQQCDSFPDCIDGS- 1365
+C+ L CDG DC DE C + C CA S C+ Q+CD F DC+D
Sbjct: 1668 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1727
Query: 1366 DELMCEIT 1373
DE C T
Sbjct: 1728 DESSCSDT 1735
Score = 44.3 bits (103), Expect = 0.001
Identities = 17/33 (51%), Positives = 20/33 (60%)
Query: 1297 VCSAAQFPCARGQCVDLRLRCDGEADCQDRSDE 1329
+CSA +FPC GQC+ CD DC D SDE
Sbjct: 73 LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105
Score = 43.1 bits (100), Expect = 0.002
Identities = 31/91 (34%), Positives = 45/91 (49%), Gaps = 10/91 (10%)
Query: 1336 CLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP--VIG 1392
C +QF C + QCV + +CD DCIDGSDE+ C ++ P P S+ P
Sbjct: 1613 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTP----PLCSNMEFPCSTDE 1668
Query: 1393 IILSLFVMGGV---YFVCQRVVCQRYAGANG 1420
I SL + GV +F ++C + +NG
Sbjct: 1669 CIPSLLLCDGVPDCHFNEDELICSNKSCSNG 1699
Score = 40.4 bits (93), Expect = 0.014
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 1335 ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
+C ++F C SGQC+ + CDS DC D SDE
Sbjct: 73 LCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105
Score = 38.1 bits (87), Expect = 0.069
Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 17/87 (19%)
Query: 1293 EGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIK 1352
E CP F C +C+ L CD + DC DRSDEA C + +G C
Sbjct: 1392 ELCP--EITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC------AHYTSTTGSCNF-- 1441
Query: 1353 QQCDSFPDCIDGSDELMCEITKPPSDD 1379
+ G+ C +T+ DD
Sbjct: 1442 -------ETSSGNWTTACSLTQDSEDD 1461
Score = 37.4 bits (85), Expect = 0.12
Identities = 15/36 (41%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Query: 1298 CSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDEADC 1332
C+ +F C + G C++ +CD + DC D+SDEA C
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 36.2 bits (82), Expect = 0.26
Identities = 17/44 (38%), Positives = 25/44 (56%), Gaps = 5/44 (11%)
Query: 1253 CGEPPT---CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEE 1293
CG+ + CS D+F C +G+ CI CD +C D+SDE+
Sbjct: 65 CGQTQSRKLCSADEFPCTSGQ--CIAKESVCDSRQDCSDESDED 106
Score = 35.4 bits (80), Expect = 0.45
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 1336 CLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMC 1370
C N+F C S G C+ Q+CD DC D SDE C
Sbjct: 690 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 725
Score = 35.4 bits (80), Expect = 0.45
Identities = 16/44 (36%), Positives = 22/44 (50%)
Query: 1324 QDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
QD S + C ++F CA+ C+ + CD DC D SDE
Sbjct: 892 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 935
Score = 35.0 bits (79), Expect = 0.59
Identities = 24/91 (26%), Positives = 38/91 (41%), Gaps = 10/91 (10%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDS 1357
C C G+C L C+ +C D +DE +C + C G C Q D+
Sbjct: 1123 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTDENECGSSC-----TFEKGWCGWQNSQADN 1177
Query: 1358 FPDCID-GSDELMCEITKPPSDDSPAHSSAI 1387
F + GS + + +PP D + + +AI
Sbjct: 1178 FDWVLGVGSHQSL----RPPKDHTLGNENAI 1204
Score = 34.7 bits (78), Expect = 0.77
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 16/121 (13%)
Query: 1287 DDQSDEEGCPV------CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQ 1340
DD S ++ P+ C+ +F CA C+ CD DC D SDE IC
Sbjct: 887 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET--TFIC---- 940
Query: 1341 FRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIG---IILSL 1397
R +SG+C C + + D + + P + PA +G G I SL
Sbjct: 941 -RTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSL 999
Query: 1398 F 1398
F
Sbjct: 1000 F 1000
Score = 34.3 bits (77), Expect = 1.0
Identities = 35/154 (22%), Positives = 60/154 (38%), Gaps = 27/154 (17%)
Query: 1162 ILGKHLY--------WIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFS 1213
+ GK +Y W D + Q++ ++ G++ R ++ + E S+ +
Sbjct: 589 MFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGF 648
Query: 1214 AHPCARDNGGCSHICIAKGD------GTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACA 1267
A D+ + G+ P S PV L P C+ ++F C
Sbjct: 649 TGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTL----------PPHNCTDNEFICR 698
Query: 1268 TGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCS 1299
+ + CI +CD +C D+SDE C VCS
Sbjct: 699 S-DGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 731
Score = 31.6 bits (70), Expect = 6.5
Identities = 19/61 (31%), Positives = 25/61 (40%), Gaps = 5/61 (8%)
Query: 1250 LLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQ 1309
LL+ GE P+ + CI CD P+C D+SDE C A + G
Sbjct: 1384 LLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHC-----AHYTSTTGS 1438
Query: 1310 C 1310
C
Sbjct: 1439 C 1439
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 89.4 bits (220), Expect = 3e-17
Identities = 51/144 (35%), Positives = 69/144 (47%), Gaps = 6/144 (4%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCAR-GQCVDLRLRC 1317
C P + C G C RCDG+ C + DE C +C +FPC+R G C RC
Sbjct: 356 CLPWEIPCG-GNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRC 414
Query: 1318 DGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS 1377
+ + C + SDE +C C P F C + +CV CDS DC DGSDE C + P
Sbjct: 415 NYQNHCPNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTR 473
Query: 1378 DDSPAHSSAIGPVIGIILSLFVMG 1401
+ A IG +I +L + +G
Sbjct: 474 VITAA---VIGSLICGLLLVIALG 494
Score = 79.7 bits (195), Expect = 2e-14
Identities = 42/96 (43%), Positives = 49/96 (51%), Gaps = 19/96 (19%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-----PVCSAAQFPCARGQ 1309
E P C+ DQF C G+ CIP AW+C+ EC D SDEE C P +AA PCA Q
Sbjct: 143 EEPNCACDQFRCGNGK--CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 200
Query: 1310 ------------CVDLRLRCDGEADCQDRSDEADCD 1333
C+ L+CDG DC D DE DCD
Sbjct: 201 FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 236
Score = 53.5 bits (127), Expect = 2e-06
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 16/93 (17%)
Query: 1296 PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAI-----------CLPNQFRCA 1344
P C+ QF C G+C+ +C+ +C D SDE C C NQF+C
Sbjct: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
Query: 1345 SG-----QCVLIKQQCDSFPDCIDGSDELMCEI 1372
S C+ +CD DC+D DE+ C++
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 237
Score = 38.9 bits (89), Expect = 0.041
Identities = 16/43 (37%), Positives = 27/43 (62%), Gaps = 1/43 (2%)
Query: 1336 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC-EITKPPS 1377
C +QFRC +G+C+ +C++ +C D SDE +C + PP+
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPT 189
Score = 35.0 bits (79), Expect = 0.59
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 9/57 (15%)
Query: 1256 PPT------CSPDQFACA---TGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQF 1303
PPT C+ +QF C T C+P + +CDG +C D DE C V + Q+
Sbjct: 187 PPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 243
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 89.4 bits (220), Expect = 3e-17
Identities = 51/144 (35%), Positives = 69/144 (47%), Gaps = 6/144 (4%)
Query: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCAR-GQCVDLRLRC 1317
C P + C G C RCDG+ C + DE C +C +FPC+R G C RC
Sbjct: 375 CLPWEIPCG-GNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRC 433
Query: 1318 DGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPS 1377
+ + C + SDE +C C P F C + +CV CDS DC DGSDE C + P
Sbjct: 434 NYQNHCPNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTR 492
Query: 1378 DDSPAHSSAIGPVIGIILSLFVMG 1401
+ A IG +I +L + +G
Sbjct: 493 VITAA---VIGSLICGLLLVIALG 513
Score = 79.7 bits (195), Expect = 2e-14
Identities = 42/96 (43%), Positives = 49/96 (51%), Gaps = 19/96 (19%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-----PVCSAAQFPCARGQ 1309
E P C+ DQF C G+ CIP AW+C+ EC D SDEE C P +AA PCA Q
Sbjct: 162 EEPNCACDQFRCGNGK--CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 219
Query: 1310 ------------CVDLRLRCDGEADCQDRSDEADCD 1333
C+ L+CDG DC D DE DCD
Sbjct: 220 FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 255
Score = 53.5 bits (127), Expect = 2e-06
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 16/93 (17%)
Query: 1296 PVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAI-----------CLPNQFRCA 1344
P C+ QF C G+C+ +C+ +C D SDE C C NQF+C
Sbjct: 164 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 223
Query: 1345 SG-----QCVLIKQQCDSFPDCIDGSDELMCEI 1372
S C+ +CD DC+D DE+ C++
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256
Score = 38.9 bits (89), Expect = 0.041
Identities = 16/43 (37%), Positives = 27/43 (62%), Gaps = 1/43 (2%)
Query: 1336 CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC-EITKPPS 1377
C +QFRC +G+C+ +C++ +C D SDE +C + PP+
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPT 208
Score = 35.0 bits (79), Expect = 0.59
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 9/57 (15%)
Query: 1256 PPT------CSPDQFACA---TGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQF 1303
PPT C+ +QF C T C+P + +CDG +C D DE C V + Q+
Sbjct: 206 PPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 262
>gi|167555125 low density lipoprotein receptor-related protein 3 [Homo
sapiens]
Length = 770
Score = 87.8 bits (216), Expect = 8e-17
Identities = 44/123 (35%), Positives = 58/123 (47%), Gaps = 3/123 (2%)
Query: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPC--ARGQCVD 1312
+P S D + G+ C RCDG+ C DE+GCP C Q+PC G C
Sbjct: 373 QPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYT 432
Query: 1313 LRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEI 1372
RC+ + C D +DE +C + C P F C + C+ +CD DC DGSDE C
Sbjct: 433 PADRCNNQKSCPDGADEKNCFS-CQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
Query: 1373 TKP 1375
P
Sbjct: 492 AVP 494
Score = 71.2 bits (173), Expect = 7e-12
Identities = 36/92 (39%), Positives = 47/92 (51%), Gaps = 15/92 (16%)
Query: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC---------PVCSAAQFPCARG 1308
+C D+F C G+ C+PG W+C+ EC D SDE C +C FPC+
Sbjct: 165 SCQADEFRCDNGK--CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
Query: 1309 ---QCVDLRLRCDGEADCQDRSDEADC-DAIC 1336
+C+ + RCDG DC D SDEA C D C
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLAC 254
Score = 57.8 bits (138), Expect = 8e-08
Identities = 29/84 (34%), Positives = 44/84 (52%), Gaps = 11/84 (13%)
Query: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDA--------ICLPNQFRCA---SG 1346
C A +F C G+C+ +C+ +C D SDE +C A +C F C+ S
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 1347 QCVLIKQQCDSFPDCIDGSDELMC 1370
+C+ ++++CD DC DGSDE C
Sbjct: 226 RCLPVERRCDGLQDCGDGSDEAGC 249
Score = 41.6 bits (96), Expect = 0.006
Identities = 24/68 (35%), Positives = 29/68 (42%), Gaps = 12/68 (17%)
Query: 1232 GDGTPRCSCPVHLVLLQNLLTCGEPP--TCSPDQFACATGEID-CIPGAWRCDGFPECDD 1288
GDG+ +C EPP C F C+ C+P RCDG +C D
Sbjct: 192 GDGSDEGNCSA---------PASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGD 242
Query: 1289 QSDEEGCP 1296
SDE GCP
Sbjct: 243 GSDEAGCP 250
Score = 40.0 bits (92), Expect = 0.018
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 1334 AICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE--ITKPPSDDSP 1381
A C ++FRC +G+C+ QC++ +C DGSDE C ++PP P
Sbjct: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCP 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,863,481
Number of Sequences: 37866
Number of extensions: 3587382
Number of successful extensions: 16210
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 156
Number of HSP's that attempted gapping in prelim test: 11236
Number of HSP's gapped (non-prelim): 2162
length of query: 1615
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1499
effective length of database: 13,855,062
effective search space: 20768737938
effective search space used: 20768737938
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.