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Search of human proteins with 119372302
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119372302 pepsinogen 4, group I [Homo sapiens]
(388 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119372302 pepsinogen 4, group I [Homo sapiens] 787 0.0
gi|119372298 pepsinogen 3, group I [Homo sapiens] 785 0.0
gi|23943854 pepsinogen 5, group I [Homo sapiens] 783 0.0
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 406 e-113
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 389 e-108
gi|4503143 cathepsin D preproprotein [Homo sapiens] 332 3e-91
gi|4758754 napsin A preproprotein [Homo sapiens] 286 2e-77
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 267 1e-71
gi|4506475 renin preproprotein [Homo sapiens] 259 4e-69
gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo s... 159 3e-39
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 100 2e-21
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 97 2e-20
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 96 5e-20
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 94 2e-19
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 89 5e-18
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 72 1e-12
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 66 5e-11
gi|148839305 structural maintenance of chromosomes flexible hing... 35 0.12
gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens] 34 0.26
gi|119395734 breast cancer 2, early onset [Homo sapiens] 33 0.44
gi|23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens] 32 0.75
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 30 3.7
gi|15375314 LIM homeobox protein 4 [Homo sapiens] 30 4.8
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 30 4.8
gi|47419911 transcriptional intermediary factor 1 alpha isoform ... 29 6.3
gi|47419909 transcriptional intermediary factor 1 alpha isoform ... 29 6.3
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 787 bits (2032), Expect = 0.0
Identities = 388/388 (100%), Positives = 388/388 (100%)
Query: 1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60
MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP
Sbjct: 1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60
Query: 61 TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
Sbjct: 61 TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
Query: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
Sbjct: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
Query: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS
Sbjct: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
Query: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL
Sbjct: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
Query: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
WILGDVFIRQYFTVFDRANNQVGLAPVA
Sbjct: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 785 bits (2028), Expect = 0.0
Identities = 387/388 (99%), Positives = 388/388 (100%)
Query: 1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60
MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQW+AP
Sbjct: 1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP 60
Query: 61 TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
Sbjct: 61 TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
Query: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
Sbjct: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
Query: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS
Sbjct: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
Query: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL
Sbjct: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
Query: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
WILGDVFIRQYFTVFDRANNQVGLAPVA
Sbjct: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 783 bits (2021), Expect = 0.0
Identities = 385/388 (99%), Positives = 387/388 (99%)
Query: 1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60
MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP
Sbjct: 1 MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60
Query: 61 TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
Sbjct: 61 TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
Query: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
Sbjct: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
Query: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD+SGSVVIFGGIDSSYYTGS
Sbjct: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGS 240
Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
LNWVPVTVEGYWQITVDSITMNGE IACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
Query: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMN+PTESGEL
Sbjct: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGEL 360
Query: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
WILGDVFIRQYFTVFDRANNQVGLAPVA
Sbjct: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 406 bits (1043), Expect = e-113
Identities = 210/396 (53%), Positives = 276/396 (69%), Gaps = 13/396 (3%)
Query: 1 MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
MK LLLL LV L ++ +++VPL R SL++ L R L +F K HNL+ + F +
Sbjct: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58
Query: 57 WEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
+ ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC H+
Sbjct: 59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118
Query: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
RF P SSTY ++ SI YGTGS++GI+G D V V G++ Q FG S TEPG
Sbjct: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178
Query: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQ--SGSVVIFGGIDS 234
A FDGILGL YPS++ G TPVFDN+ Q LV +FSVY+S++ + +GS +IFGG D
Sbjct: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238
Query: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
S+++GSLNWVPVT + YWQI +D+I + G + C+EGCQAIVDTGTSL+TGP+ I +Q
Sbjct: 239 SHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQ 298
Query: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL----QSEGSCISGFQG 350
+ IGA+ DG+ V C+ ++ +PD+ FTINGV Y + P+AY L C SGFQG
Sbjct: 299 NAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQG 357
Query: 351 MNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAP 386
+++ +G LWILGDVFIRQ+++VFDR NN+VGLAP
Sbjct: 358 LDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAP 393
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 389 bits (998), Expect = e-108
Identities = 197/392 (50%), Positives = 265/392 (67%), Gaps = 8/392 (2%)
Query: 1 MKWLLL-LGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEA 59
MKW+++ L + L E + KVPL + KS+R T+ E+GLL +FL+ H +PA KY
Sbjct: 1 MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYR---FG 57
Query: 60 PTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFN 119
V +P+ Y+D YFG I IGTP Q+F V+FDTGSSNLWVPSVYC S ACT+H+RFN
Sbjct: 58 DLSVTYEPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFN 116
Query: 120 PEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
P +SSTY + +T S+ YG+GS+TG GYDT+ V I NQ FGLSE EPG+ YA F
Sbjct: 117 PSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176
Query: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLS-ADDQSGSVVIFGGIDSSYYT 238
DGI+GLAYP++S AT + +G ++ +FSVYLS SG V+FGG+DSS YT
Sbjct: 177 DGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYT 236
Query: 239 GSLNWVPVTVEGYWQITVDSITMNGEAIA-CAEGCQAIVDTGTSLLTGPTSPIANIQSDI 297
G + W PVT E YWQI ++ + G+A C+EGCQAIVDTGTSLLT P ++ +
Sbjct: 237 GQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQAT 296
Query: 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTES 357
GA E+ G +V+C++I +LP + F INGV++P+PPS+YIL + G C G + L +++
Sbjct: 297 GAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQN 356
Query: 358 GE-LWILGDVFIRQYFTVFDRANNQVGLAPVA 388
G+ LWILGDVF+R Y++V+D NN+VG A A
Sbjct: 357 GQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 332 bits (852), Expect = 3e-91
Identities = 183/408 (44%), Positives = 246/408 (60%), Gaps = 30/408 (7%)
Query: 5 LLLGLVALSECIMYKVPLIRKKSLRRTLSE-RGLLKDFLKKHNLNPARKYFPQWEAPTLV 63
L L L+A + ++PL + S+RRT+SE G ++D + K P KY +A V
Sbjct: 9 LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK---GPVSKYS---QAVPAV 62
Query: 64 DEQP----LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNR 117
E P L+NY+D +Y+G IGIGTP Q FTVVFDTGSSNLWVPS++C L AC H++
Sbjct: 63 TEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122
Query: 118 FNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQV-----------GGISDTNQIFGLS 166
+N + SSTY + I YG+GS++G L DTV V GG+ Q+FG +
Sbjct: 123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEA 182
Query: 167 ETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD--QSG 224
+PG A FDGILG+AYP IS + PVFDN+ Q LV Q++FS YLS D Q G
Sbjct: 183 TKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242
Query: 225 SVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLT 284
++ GG DS YY GSL+++ VT + YWQ+ +D + + C EGC+AIVDTGTSL+
Sbjct: 243 GELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMV 302
Query: 285 GPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----S 340
GP + +Q IGA G+ ++ C +S+LP I + G Y + P Y L+
Sbjct: 303 GPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAG 362
Query: 341 EGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388
+ C+SGF GM++P SG LWILGDVFI +Y+TVFDR NN+VG A A
Sbjct: 363 KTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 286 bits (732), Expect = 2e-77
Identities = 164/399 (41%), Positives = 237/399 (59%), Gaps = 27/399 (6%)
Query: 4 LLLLGLVAL--SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAPT 61
LLLL L+ + S + ++PL R + RR L+ LL+ + + L P+ AP+
Sbjct: 11 LLLLPLLNVEPSGATLIRIPLHRVQPGRRILN---LLRGWREPAEL-------PKLGAPS 60
Query: 62 LVDEQ---PLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCS--SLACTNHN 116
D+ PL NY D++YFG IG+GTP Q+FTV FDTGSSNLWVPS C S+ C H+
Sbjct: 61 PGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHH 120
Query: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
RF+P+ SS++Q+ +I YGTG + GIL D + +GGI + IFG + EP +
Sbjct: 121 RFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAF 180
Query: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS--GSVVIFGGIDS 234
A FDGILGL +P +S G P D + QGL+ + +FS YL+ D + G ++ GG D
Sbjct: 181 AHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDP 240
Query: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
++Y L +VPVTV YWQI ++ + + CA+GC AI+DTGTSL+TGPT I +
Sbjct: 241 AHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALH 300
Query: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGS----CISGFQG 350
+ IG G+ ++ CS I LP + F + GV + + Y++Q+ + C+SGFQ
Sbjct: 301 AAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQA 360
Query: 351 MNLPTESGELWILGDVFIRQYFTVFDR----ANNQVGLA 385
+++P +G WILGDVF+ Y VFDR ++ +VGLA
Sbjct: 361 LDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLA 399
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 267 bits (683), Expect = 1e-71
Identities = 140/265 (52%), Positives = 183/265 (69%), Gaps = 8/265 (3%)
Query: 1 MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
MK LLLL LV L ++ +++VPL R SL++ L R L +F K HNL+ + F +
Sbjct: 1 MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58
Query: 57 WEAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
+ ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC H+
Sbjct: 59 SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118
Query: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
RF P SSTY ++ SI YGTGS++GI+G D V V G++ Q FG S TEPG
Sbjct: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178
Query: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQ--SGSVVIFGGIDS 234
A FDGILGL YPS++ G TPVFDN+ Q LV +FSVY+S++ + +GS +IFGG D
Sbjct: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238
Query: 235 SYYTGSLNWVPVTVEGYWQITVDSI 259
S+++GSLNWVPVT + YWQI +D++
Sbjct: 239 SHFSGSLNWVPVTKQAYWQIALDNM 263
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 259 bits (661), Expect = 4e-69
Identities = 139/384 (36%), Positives = 212/384 (55%), Gaps = 30/384 (7%)
Query: 19 KVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP-------TLVDEQPLENY 71
++ L R S+R +L ERG+ + P+W P L NY
Sbjct: 33 RIFLKRMPSIRESLKERGV-----------DMARLGPEWSQPMKRLTLGNTTSSVILTNY 81
Query: 72 LDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNRFNPEDSSTYQST 129
+D +Y+G IGIGTP Q F VVFDTGSSN+WVPS CS L AC H F+ DSS+Y+
Sbjct: 82 MDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHN 141
Query: 130 SETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 189
+++ Y TG+++G L D + VGGI+ T Q+FG P A FDG++G+ +
Sbjct: 142 GTELTLRYSTGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIE 200
Query: 190 ISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS----GSVVIFGGIDSSYYTGSLNWVP 245
+ TP+FDNI +QG++ +D+FS Y + D ++ G ++ GG D +Y G+ +++
Sbjct: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260
Query: 246 VTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDG 305
+ G WQI + +++ + C +GC A+VDTG S ++G TS I + +GA +
Sbjct: 261 LIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRL-F 319
Query: 306 DMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----SEGSCISGFQGMNLPTESGELW 361
D VV C+ +LPDI F + G +Y + + Y+ Q S+ C M++P +G W
Sbjct: 320 DYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTW 379
Query: 362 ILGDVFIRQYFTVFDRANNQVGLA 385
LG FIR+++T FDR NN++G A
Sbjct: 380 ALGATFIRKFYTEFDRRNNRIGFA 403
>gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo
sapiens]
Length = 87
Score = 159 bits (403), Expect = 3e-39
Identities = 79/79 (100%), Positives = 79/79 (100%)
Query: 261 MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 320
MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI
Sbjct: 1 MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 60
Query: 321 VFTINGVQYPVPPSAYILQ 339
VFTINGVQYPVPPSAYILQ
Sbjct: 61 VFTINGVQYPVPPSAYILQ 79
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 100 bits (249), Expect = 2e-21
Identities = 96/350 (27%), Positives = 161/350 (46%), Gaps = 52/350 (14%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147
Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206
Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + +
Sbjct: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265
Query: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P + +
Sbjct: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVAR 325
Query: 300 S----ENSDG---DMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSE 341
+ E SDG ++C S P F + + + P YI
Sbjct: 326 ASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMM 385
Query: 342 GSCISGFQGMNLP------TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
G+ G+N + S ++G + ++ +FDRA +VG A
Sbjct: 386 GA------GLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 429
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 97.4 bits (241), Expect = 2e-20
Identities = 95/349 (27%), Positives = 159/349 (45%), Gaps = 46/349 (13%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Query: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSIS- 191
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYLSAD----DQS------GSVVIFGGIDSSYYTGS 240
P FD++ Q V +LFS+ L +QS G +I GGID S YTGS
Sbjct: 190 PDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGS 248
Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSD 296
L + P+ E Y+++ + + +NG+ + C E ++IVD+GT+ L P
Sbjct: 249 LWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKS 308
Query: 297 IGASENSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYI 337
I A+ +++ G+ +V C + P +F T + + P Y+
Sbjct: 309 IKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367
Query: 338 LQSEGSCISGFQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
E S ++S ++G V + ++ VFDRA ++G A
Sbjct: 368 RPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 95.9 bits (237), Expect = 5e-20
Identities = 93/332 (28%), Positives = 151/332 (45%), Gaps = 66/332 (19%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147
Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206
Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + +
Sbjct: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265
Query: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P
Sbjct: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVF--------- 316
Query: 300 SENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLP----- 354
D VV A +SL YI G+ G+N
Sbjct: 317 ------DAVVEAVARASL-----------------LYIQPMMGA------GLNYECYRFG 347
Query: 355 -TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
+ S ++G + ++ +FDRA +VG A
Sbjct: 348 ISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 379
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 94.4 bits (233), Expect = 2e-19
Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 22/227 (9%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + IGTP Q ++ DTGSSN V S + F+ E SSTY+S V++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147
Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
Y GS TG +G D V + +T+ + ++ E+E FL ++GILGLAY +++
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206
Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
SS FD++ Q + ++FS+ + + +G ++ GGI+ S Y G + +
Sbjct: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265
Query: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGP 286
P+ E Y+QI + + + G++ + C E +AIVD+GT+LL P
Sbjct: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLP 312
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 89.4 bits (220), Expect = 5e-18
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 51/339 (15%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Query: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISS 192
Y G G LG D V + ++ I ++E++ F+ + ++GILGLAY I+
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189
Query: 193 --SGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEG 250
P+ NQ S+ L SV G +I GGID S YTGSL + P+ E
Sbjct: 190 LCGAGFPL-----NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREW 233
Query: 251 YWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD-- 304
Y+++ + + +NG+ + C E ++IVD+GT+ L P I A+ +++
Sbjct: 234 YYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKF 293
Query: 305 ------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISG 347
G+ +V C + P +F T + + P Y+ E S
Sbjct: 294 PDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352
Query: 348 FQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
++S ++G V + ++ VFDRA ++G A
Sbjct: 353 DDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 391
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 71.6 bits (174), Expect = 1e-12
Identities = 85/344 (24%), Positives = 138/344 (40%), Gaps = 80/344 (23%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGA 195
Y G G LG D P D +
Sbjct: 131 PYTQGKWEGELGTDL---------------------------PDDSL------------- 150
Query: 196 TPVFDNIWNQGLVSQDLFSVYLSAD----DQS------GSVVIFGGIDSSYYTGSLNWVP 245
P FD++ Q V +LFS+ L +QS G +I GGID S YTGSL + P
Sbjct: 151 EPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTP 209
Query: 246 VTVEGYWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASE 301
+ E Y+++ + + +NG+ + C E ++IVD+GT+ L P I A+
Sbjct: 210 IRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 269
Query: 302 NSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEG 342
+++ G+ +V C + P +F T + + P Y+ E
Sbjct: 270 STEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVED 328
Query: 343 SCISGFQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
S ++S ++G V + ++ VFDRA ++G A
Sbjct: 329 VATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 372
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 66.2 bits (160), Expect = 5e-11
Identities = 80/334 (23%), Positives = 130/334 (38%), Gaps = 85/334 (25%)
Query: 76 YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
Y+ + +G+P Q ++ DTGSSN V + L H + + SSTY+ + V +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130
Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGA 195
Y G G LG D + G +P
Sbjct: 131 PYTQGKWEGELGTDL-------------------------------LCGAGFPL------ 153
Query: 196 TPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQIT 255
NQ S+ L SV G +I GGID S YTGSL + P+ E Y+++
Sbjct: 154 --------NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI 194
Query: 256 VDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD------- 304
+ + +NG+ + C E ++IVD+GT+ L P I A+ +++
Sbjct: 195 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW 254
Query: 305 -GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISGFQGMN 352
G+ +V C + P +F T + + P Y+ E S
Sbjct: 255 LGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK 313
Query: 353 LP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
++S ++G V + ++ VFDRA ++G A
Sbjct: 314 FAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 347
>gi|148839305 structural maintenance of chromosomes flexible hinge
domain containing 1 [Homo sapiens]
Length = 2005
Score = 35.0 bits (79), Expect = 0.12
Identities = 20/107 (18%), Positives = 47/107 (43%), Gaps = 11/107 (10%)
Query: 278 TGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI 337
+GTS+LTG + NI+ D + + SC ++ + + + PS+++
Sbjct: 988 SGTSILTGSAIQVQNIKKDQTLKARIE---IPSCKDVAPVEKTIKLL--------PSSHV 1036
Query: 338 LQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGL 384
+ + + G + + + + WI GD+ F ++D ++ +
Sbjct: 1037 ARLQIFSVEGQKAIQIKHQDEVNWIAGDIMHNLIFQMYDEGEREINI 1083
>gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]
Length = 1326
Score = 33.9 bits (76), Expect = 0.26
Identities = 42/186 (22%), Positives = 75/186 (40%), Gaps = 24/186 (12%)
Query: 208 VSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVT---VEGYWQITVDSITMNGE 264
V+++ ++ +A Q G + G I GS WVPV ++G + TVD + + E
Sbjct: 813 VTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQG-TKCTVDGLLEDTE 871
Query: 265 ------AIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLP 318
A+ A Q V + + + P P +Q D+ S++S+ + ++ +
Sbjct: 872 YEFRVIAVNKAGPGQPSVPSSSVVAKDPVKPPGLVQ-DLHVSDSSNSSISLAWREPAE-- 928
Query: 319 DIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRA 378
PPS YIL+ + SG + +G + RQ + RA
Sbjct: 929 -----------GDPPSGYILEMRAEDTKEWSKCTKIPISGTCYTVGGLIERQKYFFRIRA 977
Query: 379 NNQVGL 384
N+ G+
Sbjct: 978 VNEAGV 983
>gi|119395734 breast cancer 2, early onset [Homo sapiens]
Length = 3418
Score = 33.1 bits (74), Expect = 0.44
Identities = 25/78 (32%), Positives = 38/78 (48%), Gaps = 11/78 (14%)
Query: 7 LGLVALSECIMYKVPLIRKKSLRRTLSERGLL-------KDFLKKHNLNPARKYFPQWEA 59
L L L+ M K+PL+ S + +SE+ LL KDFL N P P+ E
Sbjct: 398 LTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEK 457
Query: 60 P----TLVDEQPLENYLD 73
P T+V+++ E +L+
Sbjct: 458 PLNEETVVNKRDEEQHLE 475
>gi|23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens]
Length = 732
Score = 32.3 bits (72), Expect = 0.75
Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 5/77 (6%)
Query: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTG 239
D I L P + G VF W + +VS+ + V D +SG++ + G+ + G
Sbjct: 189 DEIARLKKPDQAIKGDQFVFYEDWGENMVSKSI-PVLCVLDVESGNISVLEGVPENVSPG 247
Query: 240 SLNWVP----VTVEGYW 252
W P V G+W
Sbjct: 248 QAFWAPGDAGVVFVGWW 264
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 30.0 bits (66), Expect = 3.7
Identities = 17/43 (39%), Positives = 22/43 (51%)
Query: 326 GVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFI 368
G P+ P IL+ SG+ P+ESGEL GDVF+
Sbjct: 437 GQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFV 479
>gi|15375314 LIM homeobox protein 4 [Homo sapiens]
Length = 390
Score = 29.6 bits (65), Expect = 4.8
Identities = 22/69 (31%), Positives = 31/69 (44%)
Query: 278 TGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI 337
TG L+ G S QS + S + S S+ISSLP +NG+ Y V + I
Sbjct: 281 TGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGI 340
Query: 338 LQSEGSCIS 346
+ G +S
Sbjct: 341 IAHAGQGVS 349
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 29.6 bits (65), Expect = 4.8
Identities = 31/95 (32%), Positives = 42/95 (44%), Gaps = 12/95 (12%)
Query: 55 PQWEAPTLVDEQPLENYLDMEYFG-TIGIGT---PAQDFTVVFDTGSSNLWVPSVYCSSL 110
PQ E V + E YL+ + +IG+ T P+Q V+ SS S Y SS
Sbjct: 1399 PQHEDIYSVQDIFEEEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPPHRDSAYISSS 1458
Query: 111 ACTNHNRFNPEDSS--------TYQSTSETVSITY 137
+H F+ SS TYQSTS +S T+
Sbjct: 1459 PLGSHQVFDFRSSSSVGSPTRQTYQSTSPALSPTH 1493
>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
[Homo sapiens]
Length = 1050
Score = 29.3 bits (64), Expect = 6.3
Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Query: 288 SPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQY--PVPPSAYILQSEGSCI 345
SP+ ++ S +G S N + CS+ L +IV + + P PPS +QS S +
Sbjct: 606 SPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSV 665
>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
[Homo sapiens]
Length = 1016
Score = 29.3 bits (64), Expect = 6.3
Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%)
Query: 288 SPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQY--PVPPSAYILQSEGSCI 345
SP+ ++ S +G S N + CS+ L +IV + + P PPS +QS S +
Sbjct: 572 SPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSV 631
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,231,520
Number of Sequences: 37866
Number of extensions: 685493
Number of successful extensions: 1373
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1302
Number of HSP's gapped (non-prelim): 32
length of query: 388
length of database: 18,247,518
effective HSP length: 104
effective length of query: 284
effective length of database: 14,309,454
effective search space: 4063884936
effective search space used: 4063884936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.