Guide to the Human Genome
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Search of human proteins with 119372298

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119372298 pepsinogen 3, group I [Homo sapiens]
         (388 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119372298 pepsinogen 3, group I [Homo sapiens]                     787   0.0  
gi|119372302 pepsinogen 4, group I [Homo sapiens]                     785   0.0  
gi|23943854 pepsinogen 5, group I [Homo sapiens]                      781   0.0  
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]         406   e-113
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]                389   e-108
gi|4503143 cathepsin D preproprotein [Homo sapiens]                   332   3e-91
gi|4758754 napsin A preproprotein [Homo sapiens]                      286   2e-77
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]        268   8e-72
gi|4506475 renin preproprotein [Homo sapiens]                         259   4e-69
gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo s...   159   3e-39
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot...   100   2e-21
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote...    97   2e-20
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot...    96   5e-20
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot...    94   2e-19
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot...    89   5e-18
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot...    72   1e-12
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot...    66   5e-11
gi|148839305 structural maintenance of chromosomes flexible hing...    35   0.12 
gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]      34   0.26 
gi|23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens]           32   0.75 
gi|119395734 breast cancer 2, early onset [Homo sapiens]               32   1.3  
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]            30   3.7  
gi|15375314 LIM homeobox protein 4 [Homo sapiens]                      30   4.8  
gi|47419911 transcriptional intermediary factor 1 alpha isoform ...    29   6.3  
gi|47419909 transcriptional intermediary factor 1 alpha isoform ...    29   6.3  
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...    29   8.3  

>gi|119372298 pepsinogen 3, group I [Homo sapiens]
          Length = 388

 Score =  787 bits (2032), Expect = 0.0
 Identities = 388/388 (100%), Positives = 388/388 (100%)

Query: 1   MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP 60
           MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP
Sbjct: 1   MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP 60

Query: 61  TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
           TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
Sbjct: 61  TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120

Query: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
           EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
Sbjct: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180

Query: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
           GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS
Sbjct: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240

Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
           LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300

Query: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
           ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL
Sbjct: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360

Query: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
           WILGDVFIRQYFTVFDRANNQVGLAPVA
Sbjct: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388


>gi|119372302 pepsinogen 4, group I [Homo sapiens]
          Length = 388

 Score =  785 bits (2028), Expect = 0.0
 Identities = 387/388 (99%), Positives = 388/388 (100%)

Query: 1   MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP 60
           MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQW+AP
Sbjct: 1   MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60

Query: 61  TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
           TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
Sbjct: 61  TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120

Query: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
           EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
Sbjct: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180

Query: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
           GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS
Sbjct: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240

Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
           LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300

Query: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
           ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL
Sbjct: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360

Query: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
           WILGDVFIRQYFTVFDRANNQVGLAPVA
Sbjct: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388


>gi|23943854 pepsinogen 5, group I [Homo sapiens]
          Length = 388

 Score =  781 bits (2017), Expect = 0.0
 Identities = 384/388 (98%), Positives = 387/388 (99%)

Query: 1   MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP 60
           MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQW+AP
Sbjct: 1   MKWLLLLGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP 60

Query: 61  TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120
           TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP
Sbjct: 61  TLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNP 120

Query: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180
           EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD
Sbjct: 121 EDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFD 180

Query: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGS 240
           GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD+SGSVVIFGGIDSSYYTGS
Sbjct: 181 GILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKSGSVVIFGGIDSSYYTGS 240

Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300
           LNWVPVTVEGYWQITVDSITMNGE IACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS
Sbjct: 241 LNWVPVTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGAS 300

Query: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGEL 360
           ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMN+PTESGEL
Sbjct: 301 ENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNVPTESGEL 360

Query: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388
           WILGDVFIRQYFTVFDRANNQVGLAPVA
Sbjct: 361 WILGDVFIRQYFTVFDRANNQVGLAPVA 388


>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
          Length = 396

 Score =  406 bits (1044), Expect = e-113
 Identities = 210/396 (53%), Positives = 276/396 (69%), Gaps = 13/396 (3%)

Query: 1   MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
           MK LLLL LV L    ++  +++VPL R  SL++ L  R  L +F K HNL+  +  F +
Sbjct: 1   MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58

Query: 57  WKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
             +     ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC  H+
Sbjct: 59  SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118

Query: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
           RF P  SSTY    ++ SI YGTGS++GI+G D V V G++   Q FG S TEPG     
Sbjct: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178

Query: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQ--SGSVVIFGGIDS 234
           A FDGILGL YPS++  G TPVFDN+  Q LV   +FSVY+S++ +  +GS +IFGG D 
Sbjct: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238

Query: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
           S+++GSLNWVPVT + YWQI +D+I + G  + C+EGCQAIVDTGTSL+TGP+  I  +Q
Sbjct: 239 SHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQ 298

Query: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYIL----QSEGSCISGFQG 350
           + IGA+   DG+  V C+ ++ +PD+ FTINGV Y + P+AY L         C SGFQG
Sbjct: 299 NAIGAAP-VDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQG 357

Query: 351 MNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAP 386
           +++   +G LWILGDVFIRQ+++VFDR NN+VGLAP
Sbjct: 358 LDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAP 393


>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
          Length = 388

 Score =  389 bits (998), Expect = e-108
 Identities = 197/392 (50%), Positives = 265/392 (67%), Gaps = 8/392 (2%)

Query: 1   MKWLLL-LGLVALSECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKA 59
           MKW+++ L  + L E  + KVPL + KS+R T+ E+GLL +FL+ H  +PA KY      
Sbjct: 1   MKWMVVVLVCLQLLEAAVVKVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYR---FG 57

Query: 60  PTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFN 119
              V  +P+  Y+D  YFG I IGTP Q+F V+FDTGSSNLWVPSVYC S ACT+H+RFN
Sbjct: 58  DLSVTYEPMA-YMDAAYFGEISIGTPPQNFLVLFDTGSSNLWVPSVYCQSQACTSHSRFN 116

Query: 120 PEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPF 179
           P +SSTY +  +T S+ YG+GS+TG  GYDT+ V  I   NQ FGLSE EPG+   YA F
Sbjct: 117 PSESSTYSTNGQTFSLQYGSGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQF 176

Query: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLS-ADDQSGSVVIFGGIDSSYYT 238
           DGI+GLAYP++S   AT     +  +G ++  +FSVYLS     SG  V+FGG+DSS YT
Sbjct: 177 DGIMGLAYPALSVDEATTAMQGMVQEGALTSPVFSVYLSNQQGSSGGAVVFGGVDSSLYT 236

Query: 239 GSLNWVPVTVEGYWQITVDSITMNGEAIA-CAEGCQAIVDTGTSLLTGPTSPIANIQSDI 297
           G + W PVT E YWQI ++   + G+A   C+EGCQAIVDTGTSLLT P   ++ +    
Sbjct: 237 GQIYWAPVTQELYWQIGIEEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQAT 296

Query: 298 GASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTES 357
           GA E+  G  +V+C++I +LP + F INGV++P+PPS+YIL + G C  G +   L +++
Sbjct: 297 GAQEDEYGQFLVNCNSIQNLPSLTFIINGVEFPLPPSSYILSNNGYCTVGVEPTYLSSQN 356

Query: 358 GE-LWILGDVFIRQYFTVFDRANNQVGLAPVA 388
           G+ LWILGDVF+R Y++V+D  NN+VG A  A
Sbjct: 357 GQPLWILGDVFLRSYYSVYDLGNNRVGFATAA 388


>gi|4503143 cathepsin D preproprotein [Homo sapiens]
          Length = 412

 Score =  332 bits (851), Expect = 3e-91
 Identities = 183/408 (44%), Positives = 246/408 (60%), Gaps = 30/408 (7%)

Query: 5   LLLGLVALSECIMYKVPLIRKKSLRRTLSE-RGLLKDFLKKHNLNPARKYFPQWKAPTLV 63
           L L L+A     + ++PL +  S+RRT+SE  G ++D + K    P  KY    +A   V
Sbjct: 9   LALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAK---GPVSKYS---QAVPAV 62

Query: 64  DEQP----LENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNR 117
            E P    L+NY+D +Y+G IGIGTP Q FTVVFDTGSSNLWVPS++C  L  AC  H++
Sbjct: 63  TEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHK 122

Query: 118 FNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQV-----------GGISDTNQIFGLS 166
           +N + SSTY     +  I YG+GS++G L  DTV V           GG+    Q+FG +
Sbjct: 123 YNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEA 182

Query: 167 ETEPGSFLYYAPFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADD--QSG 224
             +PG     A FDGILG+AYP IS +   PVFDN+  Q LV Q++FS YLS D   Q G
Sbjct: 183 TKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPG 242

Query: 225 SVVIFGGIDSSYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLT 284
             ++ GG DS YY GSL+++ VT + YWQ+ +D + +      C EGC+AIVDTGTSL+ 
Sbjct: 243 GELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMV 302

Query: 285 GPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----S 340
           GP   +  +Q  IGA     G+ ++ C  +S+LP I   + G  Y + P  Y L+     
Sbjct: 303 GPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAG 362

Query: 341 EGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA 388
           +  C+SGF GM++P  SG LWILGDVFI +Y+TVFDR NN+VG A  A
Sbjct: 363 KTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAA 410


>gi|4758754 napsin A preproprotein [Homo sapiens]
          Length = 420

 Score =  286 bits (732), Expect = 2e-77
 Identities = 164/399 (41%), Positives = 237/399 (59%), Gaps = 27/399 (6%)

Query: 4   LLLLGLVAL--SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAPT 61
           LLLL L+ +  S   + ++PL R +  RR L+   LL+ + +   L       P+  AP+
Sbjct: 11  LLLLPLLNVEPSGATLIRIPLHRVQPGRRILN---LLRGWREPAEL-------PKLGAPS 60

Query: 62  LVDEQ---PLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCS--SLACTNHN 116
             D+    PL NY D++YFG IG+GTP Q+FTV FDTGSSNLWVPS  C   S+ C  H+
Sbjct: 61  PGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHH 120

Query: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
           RF+P+ SS++Q+     +I YGTG + GIL  D + +GGI   + IFG +  EP     +
Sbjct: 121 RFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAF 180

Query: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS--GSVVIFGGIDS 234
           A FDGILGL +P +S  G  P  D +  QGL+ + +FS YL+ D +   G  ++ GG D 
Sbjct: 181 AHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDP 240

Query: 235 SYYTGSLNWVPVTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQ 294
           ++Y   L +VPVTV  YWQI ++ + +      CA+GC AI+DTGTSL+TGPT  I  + 
Sbjct: 241 AHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALH 300

Query: 295 SDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGS----CISGFQG 350
           + IG      G+ ++ CS I  LP + F + GV + +    Y++Q+  +    C+SGFQ 
Sbjct: 301 AAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQA 360

Query: 351 MNLPTESGELWILGDVFIRQYFTVFDR----ANNQVGLA 385
           +++P  +G  WILGDVF+  Y  VFDR    ++ +VGLA
Sbjct: 361 LDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLA 399


>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
          Length = 363

 Score =  268 bits (684), Expect = 8e-72
 Identities = 140/265 (52%), Positives = 183/265 (69%), Gaps = 8/265 (3%)

Query: 1   MKWLLLLGLVAL----SECIMYKVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQ 56
           MK LLLL LV L    ++  +++VPL R  SL++ L  R  L +F K HNL+  +  F +
Sbjct: 1   MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQ--FTE 58

Query: 57  WKAPTLVDEQPLENYLDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHN 116
             +     ++PL NYLDMEYFGTI IG+P Q+FTV+FDTGSSNLWVPSVYC+S AC  H+
Sbjct: 59  SCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHS 118

Query: 117 RFNPEDSSTYQSTSETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYY 176
           RF P  SSTY    ++ SI YGTGS++GI+G D V V G++   Q FG S TEPG     
Sbjct: 119 RFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVD 178

Query: 177 APFDGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQ--SGSVVIFGGIDS 234
           A FDGILGL YPS++  G TPVFDN+  Q LV   +FSVY+S++ +  +GS +IFGG D 
Sbjct: 179 AEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDH 238

Query: 235 SYYTGSLNWVPVTVEGYWQITVDSI 259
           S+++GSLNWVPVT + YWQI +D++
Sbjct: 239 SHFSGSLNWVPVTKQAYWQIALDNM 263


>gi|4506475 renin preproprotein [Homo sapiens]
          Length = 406

 Score =  259 bits (661), Expect = 4e-69
 Identities = 139/384 (36%), Positives = 212/384 (55%), Gaps = 30/384 (7%)

Query: 19  KVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP-------TLVDEQPLENY 71
           ++ L R  S+R +L ERG+              +  P+W  P              L NY
Sbjct: 33  RIFLKRMPSIRESLKERGV-----------DMARLGPEWSQPMKRLTLGNTTSSVILTNY 81

Query: 72  LDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNRFNPEDSSTYQST 129
           +D +Y+G IGIGTP Q F VVFDTGSSN+WVPS  CS L  AC  H  F+  DSS+Y+  
Sbjct: 82  MDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHN 141

Query: 130 SETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 189
              +++ Y TG+++G L  D + VGGI+ T Q+FG     P      A FDG++G+ +  
Sbjct: 142 GTELTLRYSTGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIE 200

Query: 190 ISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS----GSVVIFGGIDSSYYTGSLNWVP 245
            +    TP+FDNI +QG++ +D+FS Y + D ++    G  ++ GG D  +Y G+ +++ 
Sbjct: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260

Query: 246 VTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDG 305
           +   G WQI +  +++    + C +GC A+VDTG S ++G TS I  +   +GA +    
Sbjct: 261 LIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRL-F 319

Query: 306 DMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----SEGSCISGFQGMNLPTESGELW 361
           D VV C+   +LPDI F + G +Y +  + Y+ Q    S+  C      M++P  +G  W
Sbjct: 320 DYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTW 379

Query: 362 ILGDVFIRQYFTVFDRANNQVGLA 385
            LG  FIR+++T FDR NN++G A
Sbjct: 380 ALGATFIRKFYTEFDRRNNRIGFA 403


>gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo
           sapiens]
          Length = 87

 Score =  159 bits (403), Expect = 3e-39
 Identities = 79/79 (100%), Positives = 79/79 (100%)

Query: 261 MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 320
           MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI
Sbjct: 1   MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 60

Query: 321 VFTINGVQYPVPPSAYILQ 339
           VFTINGVQYPVPPSAYILQ
Sbjct: 61  VFTINGVQYPVPPSAYILQ 79


>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
           [Homo sapiens]
          Length = 518

 Score =  100 bits (249), Expect = 2e-21
 Identities = 96/350 (27%), Positives = 161/350 (46%), Gaps = 52/350 (14%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + IGTP Q   ++ DTGSSN  V     S +       F+ E SSTY+S    V++
Sbjct: 92  YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147

Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
            Y  GS TG +G D V +    +T+ +  ++   E+E   FL    ++GILGLAY +++ 
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206

Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
            SS     FD++  Q  +  ++FS+ +       +    +G  ++ GGI+ S Y G + +
Sbjct: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265

Query: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
            P+  E Y+QI +  + + G++  + C E    +AIVD+GT+LL  P      +   +  
Sbjct: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVAR 325

Query: 300 S----ENSDG---DMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSE 341
           +    E SDG      ++C   S  P   F           +    +  + P  YI    
Sbjct: 326 ASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMM 385

Query: 342 GSCISGFQGMNLP------TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
           G+      G+N        + S    ++G   +  ++ +FDRA  +VG A
Sbjct: 386 GA------GLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 429


>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
           [Homo sapiens]
          Length = 501

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 95/349 (27%), Positives = 159/349 (45%), Gaps = 46/349 (13%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + +G+P Q   ++ DTGSSN  V +     L    H  +  + SSTY+   + V +
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130

Query: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSIS- 191
            Y  G   G LG D V +     ++    I  ++E++   F+  + ++GILGLAY  I+ 
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189

Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYLSAD----DQS------GSVVIFGGIDSSYYTGS 240
                 P FD++  Q  V  +LFS+ L       +QS      G  +I GGID S YTGS
Sbjct: 190 PDDSLEPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGS 248

Query: 241 LNWVPVTVEGYWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSD 296
           L + P+  E Y+++ +  + +NG+ +   C E    ++IVD+GT+ L  P          
Sbjct: 249 LWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKS 308

Query: 297 IGASENSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYI 337
           I A+ +++        G+ +V C    + P  +F           T    +  + P  Y+
Sbjct: 309 IKAASSTEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367

Query: 338 LQSEGSCISGFQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
              E    S         ++S    ++G V +  ++ VFDRA  ++G A
Sbjct: 368 RPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 416


>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
           [Homo sapiens]
          Length = 468

 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 93/332 (28%), Positives = 151/332 (45%), Gaps = 66/332 (19%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + IGTP Q   ++ DTGSSN  V     S +       F+ E SSTY+S    V++
Sbjct: 92  YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147

Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
            Y  GS TG +G D V +    +T+ +  ++   E+E   FL    ++GILGLAY +++ 
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206

Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
            SS     FD++  Q  +  ++FS+ +       +    +G  ++ GGI+ S Y G + +
Sbjct: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265

Query: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGA 299
            P+  E Y+QI +  + + G++  + C E    +AIVD+GT+LL  P             
Sbjct: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVF--------- 316

Query: 300 SENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLP----- 354
                 D VV   A +SL                  YI    G+      G+N       
Sbjct: 317 ------DAVVEAVARASL-----------------LYIQPMMGA------GLNYECYRFG 347

Query: 355 -TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
            + S    ++G   +  ++ +FDRA  +VG A
Sbjct: 348 ISPSTNALVIGATVMEGFYVIFDRAQKRVGFA 379


>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
           [Homo sapiens]
          Length = 396

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 22/227 (9%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + IGTP Q   ++ DTGSSN  V     S +       F+ E SSTY+S    V++
Sbjct: 92  YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYI----DTYFDTERSSTYRSKGFDVTV 147

Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLS---ETEPGSFLYYAPFDGILGLAYPSIS- 191
            Y  GS TG +G D V +    +T+ +  ++   E+E   FL    ++GILGLAY +++ 
Sbjct: 148 KYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESE-NFFLPGIKWNGILGLAYATLAK 206

Query: 192 -SSGATPVFDNIWNQGLVSQDLFSVYL-------SADDQSGSVVIFGGIDSSYYTGSLNW 243
            SS     FD++  Q  +  ++FS+ +       +    +G  ++ GGI+ S Y G + +
Sbjct: 207 PSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWY 265

Query: 244 VPVTVEGYWQITVDSITMNGEA--IACAE--GCQAIVDTGTSLLTGP 286
            P+  E Y+QI +  + + G++  + C E    +AIVD+GT+LL  P
Sbjct: 266 TPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLP 312


>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
           [Homo sapiens]
          Length = 476

 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 51/339 (15%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + +G+P Q   ++ DTGSSN  V +     L    H  +  + SSTY+   + V +
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130

Query: 136 TYGTGSMTGILGYDTVQVG---GISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISS 192
            Y  G   G LG D V +     ++    I  ++E++   F+  + ++GILGLAY  I+ 
Sbjct: 131 PYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDK-FFINGSNWEGILGLAYAEIAR 189

Query: 193 --SGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEG 250
                 P+     NQ   S+ L SV        G  +I GGID S YTGSL + P+  E 
Sbjct: 190 LCGAGFPL-----NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREW 233

Query: 251 YWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD-- 304
           Y+++ +  + +NG+ +   C E    ++IVD+GT+ L  P          I A+ +++  
Sbjct: 234 YYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKF 293

Query: 305 ------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISG 347
                 G+ +V C    + P  +F           T    +  + P  Y+   E    S 
Sbjct: 294 PDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQ 352

Query: 348 FQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
                   ++S    ++G V +  ++ VFDRA  ++G A
Sbjct: 353 DDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 391


>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
           [Homo sapiens]
          Length = 457

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 85/344 (24%), Positives = 138/344 (40%), Gaps = 80/344 (23%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + +G+P Q   ++ DTGSSN  V +     L    H  +  + SSTY+   + V +
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130

Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGA 195
            Y  G   G LG D                            P D +             
Sbjct: 131 PYTQGKWEGELGTDL---------------------------PDDSL------------- 150

Query: 196 TPVFDNIWNQGLVSQDLFSVYLSAD----DQS------GSVVIFGGIDSSYYTGSLNWVP 245
            P FD++  Q  V  +LFS+ L       +QS      G  +I GGID S YTGSL + P
Sbjct: 151 EPFFDSLVKQTHVP-NLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTP 209

Query: 246 VTVEGYWQITVDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASE 301
           +  E Y+++ +  + +NG+ +   C E    ++IVD+GT+ L  P          I A+ 
Sbjct: 210 IRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 269

Query: 302 NSD--------GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEG 342
           +++        G+ +V C    + P  +F           T    +  + P  Y+   E 
Sbjct: 270 STEKFPDGFWLGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVED 328

Query: 343 SCISGFQGMNLP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
              S         ++S    ++G V +  ++ VFDRA  ++G A
Sbjct: 329 VATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 372


>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
           [Homo sapiens]
          Length = 432

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 80/334 (23%), Positives = 130/334 (38%), Gaps = 85/334 (25%)

Query: 76  YFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSSTYQSTSETVSI 135
           Y+  + +G+P Q   ++ DTGSSN  V +     L    H  +  + SSTY+   + V +
Sbjct: 75  YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL----HRYYQRQLSSTYRDLRKGVYV 130

Query: 136 TYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISSSGA 195
            Y  G   G LG D                                + G  +P       
Sbjct: 131 PYTQGKWEGELGTDL-------------------------------LCGAGFPL------ 153

Query: 196 TPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVTVEGYWQIT 255
                   NQ   S+ L SV        G  +I GGID S YTGSL + P+  E Y+++ 
Sbjct: 154 --------NQ---SEVLASV--------GGSMIIGGIDHSLYTGSLWYTPIRREWYYEVI 194

Query: 256 VDSITMNGEAIA--CAE--GCQAIVDTGTSLLTGPTSPIANIQSDIGASENSD------- 304
           +  + +NG+ +   C E    ++IVD+GT+ L  P          I A+ +++       
Sbjct: 195 IVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFW 254

Query: 305 -GDMVVSCSAISSLPDIVF-----------TINGVQYPVPPSAYILQSEGSCISGFQGMN 352
            G+ +V C    + P  +F           T    +  + P  Y+   E    S      
Sbjct: 255 LGEQLV-CWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK 313

Query: 353 LP-TESGELWILGDVFIRQYFTVFDRANNQVGLA 385
              ++S    ++G V +  ++ VFDRA  ++G A
Sbjct: 314 FAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFA 347


>gi|148839305 structural maintenance of chromosomes flexible hinge
            domain containing 1 [Homo sapiens]
          Length = 2005

 Score = 35.0 bits (79), Expect = 0.12
 Identities = 20/107 (18%), Positives = 47/107 (43%), Gaps = 11/107 (10%)

Query: 278  TGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI 337
            +GTS+LTG    + NI+ D       +   + SC  ++ +   +  +        PS+++
Sbjct: 988  SGTSILTGSAIQVQNIKKDQTLKARIE---IPSCKDVAPVEKTIKLL--------PSSHV 1036

Query: 338  LQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRANNQVGL 384
             + +   + G + + +  +    WI GD+     F ++D    ++ +
Sbjct: 1037 ARLQIFSVEGQKAIQIKHQDEVNWIAGDIMHNLIFQMYDEGEREINI 1083


>gi|253970427 immunoglobulin superfamily, member 22 [Homo sapiens]
          Length = 1326

 Score = 33.9 bits (76), Expect = 0.26
 Identities = 42/186 (22%), Positives = 75/186 (40%), Gaps = 24/186 (12%)

Query: 208 VSQDLFSVYLSADDQSGSVVIFGGIDSSYYTGSLNWVPVT---VEGYWQITVDSITMNGE 264
           V+++  ++  +A  Q G   + G I      GS  WVPV    ++G  + TVD +  + E
Sbjct: 813 VTKEAVTITWNAPTQDGGAPVLGYIVERRKKGSNLWVPVNKDPIQG-TKCTVDGLLEDTE 871

Query: 265 ------AIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLP 318
                 A+  A   Q  V + + +   P  P   +Q D+  S++S+  + ++    +   
Sbjct: 872 YEFRVIAVNKAGPGQPSVPSSSVVAKDPVKPPGLVQ-DLHVSDSSNSSISLAWREPAE-- 928

Query: 319 DIVFTINGVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFIRQYFTVFDRA 378
                        PPS YIL+        +        SG  + +G +  RQ +    RA
Sbjct: 929 -----------GDPPSGYILEMRAEDTKEWSKCTKIPISGTCYTVGGLIERQKYFFRIRA 977

Query: 379 NNQVGL 384
            N+ G+
Sbjct: 978 VNEAGV 983


>gi|23510451 N-acylaminoacyl-peptide hydrolase [Homo sapiens]
          Length = 732

 Score = 32.3 bits (72), Expect = 0.75
 Identities = 21/77 (27%), Positives = 33/77 (42%), Gaps = 5/77 (6%)

Query: 180 DGILGLAYPSISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQSGSVVIFGGIDSSYYTG 239
           D I  L  P  +  G   VF   W + +VS+ +  V    D +SG++ +  G+  +   G
Sbjct: 189 DEIARLKKPDQAIKGDQFVFYEDWGENMVSKSI-PVLCVLDVESGNISVLEGVPENVSPG 247

Query: 240 SLNWVP----VTVEGYW 252
              W P    V   G+W
Sbjct: 248 QAFWAPGDAGVVFVGWW 264


>gi|119395734 breast cancer 2, early onset [Homo sapiens]
          Length = 3418

 Score = 31.6 bits (70), Expect = 1.3
 Identities = 24/78 (30%), Positives = 38/78 (48%), Gaps = 11/78 (14%)

Query: 7   LGLVALSECIMYKVPLIRKKSLRRTLSERGLL-------KDFLKKHNLNPARKYFPQWKA 59
           L L  L+   M K+PL+   S  + +SE+ LL       KDFL   N  P     P+ + 
Sbjct: 398 LTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRISSLPKSEK 457

Query: 60  P----TLVDEQPLENYLD 73
           P    T+V+++  E +L+
Sbjct: 458 PLNEETVVNKRDEEQHLE 475


>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
          Length = 628

 Score = 30.0 bits (66), Expect = 3.7
 Identities = 17/43 (39%), Positives = 22/43 (51%)

Query: 326 GVQYPVPPSAYILQSEGSCISGFQGMNLPTESGELWILGDVFI 368
           G   P+ P   IL+      SG+     P+ESGEL   GDVF+
Sbjct: 437 GQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFV 479


>gi|15375314 LIM homeobox protein 4 [Homo sapiens]
          Length = 390

 Score = 29.6 bits (65), Expect = 4.8
 Identities = 22/69 (31%), Positives = 31/69 (44%)

Query: 278 TGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQYPVPPSAYI 337
           TG  L+ G  S     QS     + S   +  S S+ISSLP     +NG+ Y V  +  I
Sbjct: 281 TGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGI 340

Query: 338 LQSEGSCIS 346
           +   G  +S
Sbjct: 341 IAHAGQGVS 349


>gi|47419911 transcriptional intermediary factor 1 alpha isoform a
           [Homo sapiens]
          Length = 1050

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%)

Query: 288 SPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQY--PVPPSAYILQSEGSCI 345
           SP+ ++ S +G S N      + CS+   L +IV     + +  P PPS   +QS  S +
Sbjct: 606 SPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSV 665


>gi|47419909 transcriptional intermediary factor 1 alpha isoform b
           [Homo sapiens]
          Length = 1016

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 18/60 (30%), Positives = 29/60 (48%), Gaps = 2/60 (3%)

Query: 288 SPIANIQSDIGASENSDGDMVVSCSAISSLPDIVFTINGVQY--PVPPSAYILQSEGSCI 345
           SP+ ++ S +G S N      + CS+   L +IV     + +  P PPS   +QS  S +
Sbjct: 572 SPMIDLSSPVGGSYNLPSLPDIDCSSTIMLDNIVRKDTNIDHGQPRPPSNRTVQSPNSSV 631


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score = 28.9 bits (63), Expect = 8.3
 Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 12/81 (14%)

Query: 69   ENYLDMEYFG-TIGIGT---PAQDFTVVFDTGSSNLWVPSVYCSSLACTNHNRFNPEDSS 124
            E YL+ +    +IG+ T   P+Q   V+    SS     S Y SS    +H  F+   SS
Sbjct: 1413 EEYLEQDVENVSIGLQTEARPSQGLPVIQSPPSSPPHRDSAYISSSPLGSHQVFDFRSSS 1472

Query: 125  --------TYQSTSETVSITY 137
                    TYQSTS  +S T+
Sbjct: 1473 SVGSPTRQTYQSTSPALSPTH 1493


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,205,595
Number of Sequences: 37866
Number of extensions: 683484
Number of successful extensions: 1376
Number of sequences better than 10.0: 26
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1305
Number of HSP's gapped (non-prelim): 32
length of query: 388
length of database: 18,247,518
effective HSP length: 104
effective length of query: 284
effective length of database: 14,309,454
effective search space: 4063884936
effective search space used: 4063884936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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