Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 116642889
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116642889 cyclic nucleotide gated channel beta 3 [Homo
sapiens]
(809 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 1634 0.0
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 725 0.0
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 308 1e-83
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 308 2e-83
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 303 3e-82
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 303 3e-82
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 302 9e-82
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 245 1e-64
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 140 6e-33
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 135 1e-31
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 134 3e-31
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 133 8e-31
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 113 6e-25
gi|22024390 potassium voltage-gated channel, subfamily H, member... 107 3e-23
gi|27886648 potassium voltage-gated channel, subfamily H, member... 107 3e-23
gi|27437001 potassium voltage-gated channel, subfamily H, member... 103 8e-22
gi|27886653 potassium voltage-gated channel, subfamily H, member... 102 1e-21
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 100 9e-21
gi|27886646 potassium voltage-gated channel, subfamily H, member... 99 2e-20
gi|26051273 voltage-gated potassium channel, subfamily H, member... 95 3e-19
gi|27886667 potassium voltage-gated channel, subfamily H, member... 92 3e-18
gi|26051271 voltage-gated potassium channel, subfamily H, member... 89 2e-17
gi|13540549 potassium voltage-gated channel, subfamily H, member... 89 2e-17
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 87 5e-17
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 79 1e-14
gi|27886651 potassium voltage-gated channel, subfamily H, member... 79 1e-14
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 58 3e-08
gi|66792814 retrotransposon gag domain containing 4 [Homo sapiens] 55 2e-07
gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens] 49 2e-05
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 47 5e-05
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 1634 bits (4232), Expect = 0.0
Identities = 809/809 (100%), Positives = 809/809 (100%)
Query: 1 MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPV 60
MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPV
Sbjct: 1 MFKSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPV 60
Query: 61 TSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPA 120
TSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPA
Sbjct: 61 TSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPA 120
Query: 121 APVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKP 180
APVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKP
Sbjct: 121 APVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKP 180
Query: 181 TEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRL 240
TEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRL
Sbjct: 181 TEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRL 240
Query: 241 VFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKF 300
VFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKF
Sbjct: 241 VFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKF 300
Query: 301 QLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYL 360
QLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYL
Sbjct: 301 QLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYL 360
Query: 361 LFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEI 420
LFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEI
Sbjct: 361 LFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEI 420
Query: 421 VFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVR 480
VFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVR
Sbjct: 421 VFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVR 480
Query: 481 TWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRL 540
TWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRL
Sbjct: 481 TWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRL 540
Query: 541 KSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG 600
KSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG
Sbjct: 541 KSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG 600
Query: 601 GNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRK 660
GNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRK
Sbjct: 601 GNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRK 660
Query: 661 DLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQ 720
DLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQ
Sbjct: 661 DLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQ 720
Query: 721 KENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTS 780
KENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTS
Sbjct: 721 KENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTS 780
Query: 781 RQSLIISMAPSAEGGEEVLTIEVKEKAKQ 809
RQSLIISMAPSAEGGEEVLTIEVKEKAKQ
Sbjct: 781 RQSLIISMAPSAEGGEEVLTIEVKEKAKQ 809
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 725 bits (1871), Expect = 0.0
Identities = 399/858 (46%), Positives = 522/858 (60%), Gaps = 80/858 (9%)
Query: 14 IGENNENEQSSRRNEEGSHPSNQSQQTTAQE--ENKGE---EKSLKTKSTPVTSEEPHTN 68
+GE + E + EE + + + Q+ E K E E + P T + P
Sbjct: 409 VGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSGVPATKQHPEVQ 468
Query: 69 IQDK-------LSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPN--------- 112
++D ++++N T P P A T VP K+ P+
Sbjct: 469 VEDTDADSCPLMAEENPPS--TVLPPPSPAKSDTLIVPSSASGTHRKKLPSEDDEAEELK 526
Query: 113 --SPQNKPPAA---PVINEYADAQ-----------------LHNLVKRMRQRTALYKKKL 150
SP P A P + D Q L LVK ++RT K+KL
Sbjct: 527 ALSPAESPVVAWSDPTTPKDTDGQDRAASTASTNSAIINDRLQELVKLFKERTEKVKEKL 586
Query: 151 VEGDLSSPEASPQTAK----PTAVPPVKESDDKPTE--HYYRLLWFKVKKMPLTEYLKRI 204
++ D++S E SP+ + P P K ++ +P E HY +L K K P +Y
Sbjct: 587 IDPDVTSDEESPKPSPAKKAPEPAPDTKPAEAEPVEEEHYCDMLCCKFKHRPWKKY---- 642
Query: 205 KLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIY 264
+ P SID T+ +Y+LWL V +A+NWNC IP+R FPYQT DNIH+WL+ D +CD+IY
Sbjct: 643 QFPQSIDPLTNLMYVLWLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIY 702
Query: 265 LYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFR 324
D+ Q RLQFVRGGDII D ++R +Y S +F++D+ S++P D YL G NP+ R
Sbjct: 703 FLDITVFQTRLQFVRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNPLLR 762
Query: 325 ANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR 384
R LKY +FFEFN LESI+ KAY+YRVIRTT YLL+ LH+N+C+YYWAS Y+G+G+T
Sbjct: 763 LPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGSTH 822
Query: 385 WVYDGEGNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDV 444
WVYDG GN Y+RCYY+AV+TLITIGGLP+P+TLFEIVFQLLN+F+GVF FS +IGQMRDV
Sbjct: 823 WVYDGVGNSYIRCYYFAVKTLITIGGLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDV 882
Query: 445 IGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPT 504
+GAATA Q Y+R+CMD T+ YMN Y IPK VQ RV+TWYEYTW SQ MLDES+L+ LP
Sbjct: 883 VGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPD 942
Query: 505 TVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYII 564
++L LAIDVN++I+SKV LF+GCD QMI+DML RL+SV+YLP D+VCKKGEIG+EMYII
Sbjct: 943 KMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYII 1002
Query: 565 KHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTL 624
+ G+VQVLGGPDG VLVTLKAGSVFGEISLLA GGGNRRTANVVAHGF NL LDKK L
Sbjct: 1003 QAGQVQVLGGPDGKSVLVTLKAGSVFGEISLLAVGGGNRRTANVVAHGFTNLFILDKKDL 1062
Query: 625 QEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTG 684
EILVHYP+S+++L KKAR +L+ K P + L+ PP+ TPKLF L TG
Sbjct: 1063 NEILVHYPESQKLLRKKARRMLRSNNK-----PKEEKSVLILPPRAGTPKLFNAALAMTG 1117
Query: 685 KAS------------LARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENED 732
K ARL +L +AA K++ E+ K ++D + E +
Sbjct: 1118 KMGGKGAKGGKLAHLRARLKELAALEAAAKQQEL---VEQAKSSQDVKGEEGSAAPDQHT 1174
Query: 733 KGKE-NEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPS 791
KE D R P E P P ++ P A P P S+ I M+P
Sbjct: 1175 HPKEAATDPPAPRTPPEPPGSPP--SSPPPASLGRPEGEEEG--PAEPEEHSVRICMSPG 1230
Query: 792 AEGGEEVLTIEVKEKAKQ 809
E GE++L++++ E+ ++
Sbjct: 1231 PEPGEQILSVKMPEEREE 1248
Score = 38.1 bits (87), Expect = 0.033
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 710 EEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHS 769
EEE K E +E ++E ED+ +E E++++ E E + C S + V +
Sbjct: 334 EEENKAVEKMPRELSRIEEEKEDEEEEEEEEEEEEEEEVTEVLLDSCVVSQVGVGQSEED 393
Query: 770 VRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ 809
R P+ TS Q L E GEE E +EKAK+
Sbjct: 394 GTR---PQSTSDQKL------WEEVGEEAKK-EAEEKAKE 423
Score = 35.8 bits (81), Expect = 0.16
Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 20/115 (17%)
Query: 697 EQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPE--------- 747
+ + +K E GEE KE E+K KE ++ E E + + + + EPE
Sbjct: 398 QSTSDQKLWEEVGEEAKKEAEEKAKEEAEEVAEEEAEKEPQDWAETKEEPEAEAEAASSG 457
Query: 748 --------EKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEG 794
E ++ + + P+ EE P S TVLP + +S + + SA G
Sbjct: 458 VPATKQHPEVQVEDTDADSCPLMAEENPPS---TVLPPPSPAKSDTLIVPSSASG 509
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 308 bits (789), Expect = 1e-83
Identities = 186/559 (33%), Positives = 311/559 (55%), Gaps = 39/559 (6%)
Query: 198 TEYLKRIKLPNSID-SYTDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIA 256
TE K+ K ++I + LY WL + L +N + R F ++ + WL+
Sbjct: 147 TEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVL 206
Query: 257 DIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLF 316
D D++Y+ D+L ++ R F+ G ++ D+N L +HY+T+T+F+LDV S++P D+ YL
Sbjct: 207 DYSADVLYVLDVL-VRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLK 265
Query: 317 FGFN-PMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWAS 375
G N P R NR+LK++ FEF E+ + ++R+ Y+L I+H NAC+Y+ S
Sbjct: 266 VGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAIS 325
Query: 376 NYEGIGTTRWVYDGEG--------NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNF 427
+ G GT WVY +Y+ YW+ TL TIG P P E +F +++F
Sbjct: 326 KFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDF 385
Query: 428 FSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTW 487
GV +F++++G + +I A++ F+A +D YM + K ++ RV W++Y W
Sbjct: 386 LVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLW 445
Query: 488 DSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLP 547
+++ +DE ++LK+LP ++ +AI+V+ + KV +F+ C+ ++ +++L+L+ ++ P
Sbjct: 446 ANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSP 505
Query: 548 GDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRR 604
GD++CKKG+IGKEMYII G++ V+ DG V L GS FGEIS+L G GNRR
Sbjct: 506 GDYICKKGDIGKEMYIINEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRR 564
Query: 605 TANVVAHGFANLLTLDKKTLQEILVHYPDSERILMKKARVLLKQ----KAKTAEATPPRK 660
TAN+ + G+++L L K L E L YP++++ L +K R +L + + A A K
Sbjct: 565 TANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPK 624
Query: 661 DLALLFPPKEETPKLFKTLLGGTGKASLARLL--------KLKREQAAQKKENSEGGEE- 711
DL +E+ +L +L T + ARLL K+K+ + + + GG++
Sbjct: 625 DL------EEKVEQLGSSL--DTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKP 676
Query: 712 --EGKENEDKQKENEDKQK 728
+G+ D K EDKQ+
Sbjct: 677 LADGEVPGDATK-TEDKQQ 694
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 308 bits (788), Expect = 2e-83
Identities = 181/542 (33%), Positives = 303/542 (55%), Gaps = 38/542 (7%)
Query: 214 TDRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQP 273
+ LY WL + L +N + R F ++ + WL+ D D++Y+ D+L ++
Sbjct: 146 SSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYSADVLYVLDVL-VRA 204
Query: 274 RLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYT 332
R F+ G ++ D+N L +HY+T+T+F+LDV S++P D+ YL G N P R NR+LK++
Sbjct: 205 RTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFS 264
Query: 333 SFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEG- 391
FEF E+ + ++R+ Y+L I+H NAC+Y+ S + G GT WVY
Sbjct: 265 RLFEFFDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISI 324
Query: 392 -------NEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDV 444
+Y+ YW+ TL TIG P P E +F +++F GV +F++++G + +
Sbjct: 325 PEHGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSM 384
Query: 445 IGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPT 504
I A++ F+A +D YM + K ++ RV W++Y W +++ +DE ++LK+LP
Sbjct: 385 ISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPD 444
Query: 505 TVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYII 564
++ +AI+V+ + KV +F+ C+ ++ +++L+L+ ++ PGD++CKKG+IGKEMYII
Sbjct: 445 KLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYII 504
Query: 565 KHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDK 621
G++ V+ DG V L GS FGEIS+L G GNRRTAN+ + G+++L L K
Sbjct: 505 NEGKLAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSK 563
Query: 622 KTLQEILVHYPDSERILMKKARVLLKQ----KAKTAEATPPRKDLALLFPPKEETPKLFK 677
L E L YP++++ L +K R +L + + A A KDL +E+ +L
Sbjct: 564 DDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDL------EEKVEQLGS 617
Query: 678 TLLGGTGKASLARLL--------KLKREQAAQKKENSEGGEE---EGKENEDKQKENEDK 726
+L T + ARLL K+K+ + + + GG++ +G+ D K EDK
Sbjct: 618 SL--DTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATK-TEDK 674
Query: 727 QK 728
Q+
Sbjct: 675 QQ 676
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 303 bits (777), Expect = 3e-82
Identities = 161/441 (36%), Positives = 260/441 (58%), Gaps = 14/441 (3%)
Query: 218 YLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQF 277
Y WL +TL +N + R F +D + YWLI D + DI+YL DM F++ R +
Sbjct: 234 YYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDM-FVRTRTGY 292
Query: 278 VRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYTSFFE 336
+ G ++ + +L Y+++ +F+LDV S+IP D+ Y G+N P R NR+L+++ FE
Sbjct: 293 LEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFE 352
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVY----DGE-- 390
F E+ + I+R+ Y++ I+H NACV+Y S G G WVY D E
Sbjct: 353 FFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFG 412
Query: 391 --GNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448
+Y+ YW+ TL TIG P P E VF +++F GV +F++++G + +I
Sbjct: 413 RLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNM 472
Query: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508
A + F+A +D YM+ ++ K ++KRV W++Y W +++ +DE ++LK LP ++
Sbjct: 473 NAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRA 532
Query: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568
+AI+V+ + KV +F C+ ++ +++L+L+ +Y PGD++CKKG+IG+EMYIIK G+
Sbjct: 533 EIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGK 592
Query: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQ 625
+ V+ DG V L GS FGEIS+L G GNRRTAN+ + G+++L L K L
Sbjct: 593 LAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLM 651
Query: 626 EILVHYPDSERILMKKARVLL 646
E L YPD++ +L +K + +L
Sbjct: 652 EALTEYPDAKTMLEEKGKQIL 672
Score = 35.4 bits (80), Expect = 0.21
Identities = 13/48 (27%), Positives = 31/48 (64%)
Query: 695 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDK 742
K+++ +KK S+ E + E K+K+ + ++K+ E+K K+ ++++K
Sbjct: 174 KKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEK 221
Score = 35.0 bits (79), Expect = 0.28
Identities = 17/54 (31%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 696 REQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEK 749
+E +KK+ E + +NE+K + K+K++++K K+ E+K K ++ EEK
Sbjct: 169 QEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEK-KKKEEKSKDKKEEEK 221
Score = 33.9 bits (76), Expect = 0.62
Identities = 14/48 (29%), Positives = 28/48 (58%)
Query: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDK 740
K K+++ + K + + + E + K+K+ E K+KE + K K+ E+K
Sbjct: 174 KKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEK 221
Score = 33.5 bits (75), Expect = 0.81
Identities = 15/66 (22%), Positives = 35/66 (53%)
Query: 705 NSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVE 764
N + +E E+K+K+ ++K+ +++DK + D +K ++ ++K + E + E
Sbjct: 160 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE 219
Query: 765 EEPHSV 770
E+ V
Sbjct: 220 EKKEVV 225
Score = 33.5 bits (75), Expect = 0.81
Identities = 18/53 (33%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Query: 697 EQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEK 749
E+ +KK+ + ++ EN++ E + K+K+ E K KE + KDK +E E+K
Sbjct: 172 EEKKKKKKEKKSKSDDKNENKN-DPEKKKKKKDKEKKKKEEKSKDK-KEEEKK 222
Score = 31.2 bits (69), Expect = 4.0
Identities = 12/44 (27%), Positives = 28/44 (63%)
Query: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKE 736
K K+ ++ K EN E++ K+ + ++K+ E+K K+ +++ K+
Sbjct: 179 KEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKK 222
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 303 bits (777), Expect = 3e-82
Identities = 161/441 (36%), Positives = 260/441 (58%), Gaps = 14/441 (3%)
Query: 218 YLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQF 277
Y WL +TL +N + R F +D + YWLI D + DI+YL DM F++ R +
Sbjct: 165 YYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDM-FVRTRTGY 223
Query: 278 VRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYTSFFE 336
+ G ++ + +L Y+++ +F+LDV S+IP D+ Y G+N P R NR+L+++ FE
Sbjct: 224 LEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFE 283
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVY----DGE-- 390
F E+ + I+R+ Y++ I+H NACV+Y S G G WVY D E
Sbjct: 284 FFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDTWVYPDINDPEFG 343
Query: 391 --GNEYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448
+Y+ YW+ TL TIG P P E VF +++F GV +F++++G + +I
Sbjct: 344 RLARKYVYSLYWSTLTLTTIGETPPPVRDSEYVFVVVDFLIGVLIFATIVGNIGSMISNM 403
Query: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508
A + F+A +D YM+ ++ K ++KRV W++Y W +++ +DE ++LK LP ++
Sbjct: 404 NAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRA 463
Query: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568
+AI+V+ + KV +F C+ ++ +++L+L+ +Y PGD++CKKG+IG+EMYIIK G+
Sbjct: 464 EIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGK 523
Query: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQ 625
+ V+ DG V L GS FGEIS+L G GNRRTAN+ + G+++L L K L
Sbjct: 524 LAVV-ADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLM 582
Query: 626 EILVHYPDSERILMKKARVLL 646
E L YPD++ +L +K + +L
Sbjct: 583 EALTEYPDAKTMLEEKGKQIL 603
Score = 35.4 bits (80), Expect = 0.21
Identities = 13/48 (27%), Positives = 31/48 (64%)
Query: 695 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDK 742
K+++ +KK S+ E + E K+K+ + ++K+ E+K K+ ++++K
Sbjct: 105 KKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEK 152
Score = 35.0 bits (79), Expect = 0.28
Identities = 17/54 (31%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 696 REQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEK 749
+E +KK+ E + +NE+K + K+K++++K K+ E+K K ++ EEK
Sbjct: 100 QEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEK-KKKEEKSKDKKEEEK 152
Score = 33.9 bits (76), Expect = 0.62
Identities = 14/48 (29%), Positives = 28/48 (58%)
Query: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDK 740
K K+++ + K + + + E + K+K+ E K+KE + K K+ E+K
Sbjct: 105 KKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEK 152
Score = 33.5 bits (75), Expect = 0.81
Identities = 15/66 (22%), Positives = 35/66 (53%)
Query: 705 NSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVE 764
N + +E E+K+K+ ++K+ +++DK + D +K ++ ++K + E + E
Sbjct: 91 NVNNSSNKDQEPEEKKKKKKEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEE 150
Query: 765 EEPHSV 770
E+ V
Sbjct: 151 EKKEVV 156
Score = 33.5 bits (75), Expect = 0.81
Identities = 18/53 (33%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Query: 697 EQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEK 749
E+ +KK+ + ++ EN++ E + K+K+ E K KE + KDK +E E+K
Sbjct: 103 EEKKKKKKEKKSKSDDKNENKN-DPEKKKKKKDKEKKKKEEKSKDK-KEEEKK 153
Score = 31.2 bits (69), Expect = 4.0
Identities = 12/44 (27%), Positives = 28/44 (63%)
Query: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKE 736
K K+ ++ K EN E++ K+ + ++K+ E+K K+ +++ K+
Sbjct: 110 KEKKSKSDDKNENKNDPEKKKKKKDKEKKKKEEKSKDKKEEEKK 153
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 302 bits (773), Expect = 9e-82
Identities = 188/614 (30%), Positives = 311/614 (50%), Gaps = 49/614 (7%)
Query: 50 EKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQK--EMDPG 107
EK+ KS+P + H K N D T+ P +AA+ + Q+ ++D
Sbjct: 3 EKTNGVKSSPANNHNHHA---PPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAP 59
Query: 108 KEGPNSPQNKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKP 167
++G + + +I E+A+ R ++ PE T +
Sbjct: 60 QQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFR---------GPELQTVTTQE 110
Query: 168 TAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTL 227
K+ +DK T+ + L +D D Y WL ++ +
Sbjct: 111 GDGKGDKDGEDKGTKKKFELF--------------------VLDPAGD-WYYCWLFVIAM 149
Query: 228 AYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDS 287
+N C + R F WL+ D + D++Y+ D LFI+ R F+ G ++ D+
Sbjct: 150 PVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIAD-LFIRLRTGFLEQGLLVKDT 208
Query: 288 NELRKHYRTSTKFQLDVASIIPFDICYLFFGFN-PMFRANRMLKYTSFFEFNHHLESIMD 346
+LR +Y + +F+LDVASIIP D+ Y + P R NR+L + FEF E+ +
Sbjct: 209 KKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTN 268
Query: 347 KAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVY----DGE----GNEYLRCY 398
I+R+ Y+L I+H NAC+YY S G G WVY D E EY+ C
Sbjct: 269 YPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCL 328
Query: 399 YWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRAC 458
YW+ TL TIG P P E +F + +F GV +F++++G + +I A + F+A
Sbjct: 329 YWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAK 388
Query: 459 MDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSI 518
+D YM + K ++ +V W++Y W +++ +DE ++LK LP ++ +AI+V+ S
Sbjct: 389 IDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLST 448
Query: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578
+ KV +F C+ ++ +++L+L+ ++ PGD++C+KG+IGKEMYIIK G++ V+ DG
Sbjct: 449 LKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVV-ADDGV 507
Query: 579 KVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSE 635
L AGS FGEIS+L G GNRRTAN+ + G+++L L K L E + YPD++
Sbjct: 508 TQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAK 567
Query: 636 RILMKKARVLLKQK 649
++L ++ R +L ++
Sbjct: 568 KVLEERGREILMKE 581
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 245 bits (625), Expect = 1e-64
Identities = 154/544 (28%), Positives = 270/544 (49%), Gaps = 27/544 (4%)
Query: 218 YLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQF 277
Y WL + +N + R FP + WL+ D D++YL DM+ ++ F
Sbjct: 34 YYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV-VRFHTGF 92
Query: 278 VRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG-FNPMFRANRMLKYTSFFE 336
+ G ++VD + Y + F LD+AS++P D+ Y+ G P R NR L+ FE
Sbjct: 93 LEQGILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYVRLGPHTPTLRLNRFLRAPRLFE 152
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGN---- 392
E+ +R+ + Y+ ++H N+C+Y+ S Y G G WVY
Sbjct: 153 AFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFE 212
Query: 393 ----EYLRCYYWAVRTLITIGGLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448
+YL +Y++ L T+G P P E +F + +F V F++++G M VI
Sbjct: 213 RLRRQYLYSFYFSTLILTTVGDTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNM 272
Query: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508
F YM + + +++RV WY++ +++M +E +L+ LP ++
Sbjct: 273 NTADAAFYPDHALVKKYMKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRA 332
Query: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568
+A+ V+ S +S+V +F+ C+ ++ +++L+L+ Y PG++VC+KG+IG+EMYII+ G+
Sbjct: 333 EVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQ 392
Query: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGG---GNRRTANVVAHGFANLLTLDKKTLQ 625
+ V+ DG L AG FGEIS++ G GNRRTAN+ + G+++L L K+ L+
Sbjct: 393 LAVV-ADDGITQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLR 451
Query: 626 EILVHYPDSERILMKKAR-VLLK--------QKAKTAEATPPRKDLALLFPPKEETPKLF 676
E+L YP ++ I+ +K R +LLK + A+ A L L ++ F
Sbjct: 452 EVLSEYPQAQTIMEEKGREILLKMNKLDVNAEAAEIALQEATESRLRGLDQQLDDLQTKF 511
Query: 677 KTLLGGTGKASLARLLKLKREQAAQKK----ENSEGGEEEGKENEDKQKENEDKQKENED 732
LL ++L +++R + ++ E+ ++EG+ E K+ E + +
Sbjct: 512 ARLLAELESSALKIAYRIERLEWQTREWPMPEDLAEADDEGEPEEGTSKDEEGRASQEGP 571
Query: 733 KGKE 736
G E
Sbjct: 572 PGPE 575
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 140 bits (352), Expect = 6e-33
Identities = 115/463 (24%), Positives = 205/463 (44%), Gaps = 52/463 (11%)
Query: 210 IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDM 268
I Y+D R Y W L + L N IP+ + F +N W++ +++ D +L D+
Sbjct: 255 IHPYSDFRFY--WDLTMLLLMVGNLIIIPVGITFFKD--ENTTPWIVFNVVSDTFFLIDL 310
Query: 269 LF-IQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG--------- 318
+ + + +II+D ++ Y S F +D S IP D +L
Sbjct: 311 VLNFRTGIVVEDNTEIILDPQRIKMKYLKSW-FMVDFISSIPVDYIFLIVETRIDSEVYK 369
Query: 319 ---------FNPMFRANRMLKYTSFFEFNHHLESIMDKAY-----IYRVIRTTGYLLFIL 364
F + R+L+ + + H E I Y + R++ G +L +
Sbjct: 370 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLC 429
Query: 365 HINACVYYWASNYEGIGTTRWVY------DGEGNEYLRCYYWAVRTLITIG-GLPEPQTL 417
H + C+ + + WV + G +Y + A+ ++ IG G P +
Sbjct: 430 HWDGCLQFLVPMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGM 489
Query: 418 FEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQK 477
++ +L+ G ++ IG +I + +++ ++ YM+ + +P ++
Sbjct: 490 SDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQ 549
Query: 478 RVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---IISKVDLFKGCDTQMIY 534
R+ +YE+ + +M DE +L L ++ + +NF+ +++ + LF D +
Sbjct: 550 RIHDYYEHRYQG-KMFDEESILGELSEPLREEI---INFNCRKLVASMPLFANADPNFVT 605
Query: 535 DMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVL-GGPDGTKVLVTLKAGSVFGEI 593
ML +L+ ++ PGD++ ++G IGK+MY I+HG V VL G TK L GS FGEI
Sbjct: 606 SMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETK----LADGSYFGEI 661
Query: 594 SLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636
LL G RRTA+V A + L +L E+L YP R
Sbjct: 662 CLLTRG---RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 701
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 135 bits (341), Expect = 1e-31
Identities = 128/538 (23%), Positives = 230/538 (42%), Gaps = 69/538 (12%)
Query: 152 EGDLSSPEASPQTAKPTAVP---PVKESDDKPTE-HYYRLLWFKVKKMPLTEY------- 200
EG EA P A P A P+ +S +P H LL V K L +
Sbjct: 13 EGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVE 72
Query: 201 --LKRIKLPNS--IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLI 255
+R+K + I Y+D R Y W L++ L N +P+ + F + +N W++
Sbjct: 73 IEQERVKSAGAWIIHPYSDFRFY--WDLIMLLLMVGNLIVLPVGITFFKE--ENSPPWIV 128
Query: 256 ADIICDIIYLYDMLF-IQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICY 314
+++ D +L D++ + + G +I++ +R Y T F +D+ S IP D +
Sbjct: 129 FNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRY-LRTWFLVDLISSIPVDYIF 187
Query: 315 LFFGFNPMFRAN--------------------RMLKYTSFFEFNHHLESIMDKAY----- 349
L P A R+L+ + + H E I Y
Sbjct: 188 LVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 247
Query: 350 IYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGE------GNEYLRCYYWAVR 403
+ R+ G +L + H + C+ + + WV G +Y + A+
Sbjct: 248 VVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMS 307
Query: 404 TLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDT 462
++ IG G P + ++ +L+ G ++ IG +I + +++ ++
Sbjct: 308 HMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQV 367
Query: 463 IAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---II 519
YM+ + +P ++R+ +YE+ + +M DE +L L ++ + +NF+ ++
Sbjct: 368 EQYMSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEI---INFTCRGLV 423
Query: 520 SKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLG-GPDGT 578
+ + LF D + +L +L+ ++ PGD V ++G +G++MY I+HG + VL G T
Sbjct: 424 AHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDT 483
Query: 579 KVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636
+ L GS FGEI LL G RRTA+V A + L +L +L +P R
Sbjct: 484 R----LTDGSYFGEICLLTRG---RRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRR 534
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 134 bits (337), Expect = 3e-31
Identities = 115/462 (24%), Positives = 205/462 (44%), Gaps = 50/462 (10%)
Query: 210 IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDM 268
I Y+D R Y W + L N IP+ + F + W++ +++ D +L D+
Sbjct: 204 IHPYSDFRFY--WDFTMLLFMVGNLIIIPVGITFFKD--ETTAPWIVFNVVSDTFFLMDL 259
Query: 269 LF-IQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG--------- 318
+ + + +II+D +++K Y T F +D S IP D +L
Sbjct: 260 VLNFRTGIVIEDNTEIILDPEKIKKKY-LRTWFVVDFVSSIPVDYIFLIVEKGIDSEVYK 318
Query: 319 ---------FNPMFRANRMLKYTSFFEFNHHLESIMDKAY-----IYRVIRTTGYLLFIL 364
F + R+L+ + + H E I Y + R+ +L +
Sbjct: 319 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNLISMMLLLC 378
Query: 365 HINACVYYWASNYEGIGTTRWV-YDGEGNE-----YLRCYYWAVRTLITIG-GLPEPQTL 417
H + C+ + + WV +G N Y + A+ ++ IG G P+++
Sbjct: 379 HWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFKAMSHMLCIGYGRQAPESM 438
Query: 418 FEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQK 477
+I +L+ G ++ IG +I + +++ ++ YM+ + +P ++
Sbjct: 439 TDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQ 498
Query: 478 RVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---IISKVDLFKGCDTQMIY 534
++ +YE+ + +M DE +L L ++ + VNF+ +++ + LF D +
Sbjct: 499 KIHDYYEHRYQG-KMFDEDSILGELNGPLREEI---VNFNCRKLVASMPLFANADPNFVT 554
Query: 535 DMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEIS 594
ML +LK ++ PGD++ ++G IGK+MY I+HG V VL G K + L GS FGEI
Sbjct: 555 AMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL--TKGNKEM-KLSDGSYFGEIC 611
Query: 595 LLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636
LL G RRTA+V A + L +L E+L YP R
Sbjct: 612 LLTRG---RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 133 bits (334), Expect = 8e-31
Identities = 111/467 (23%), Positives = 207/467 (44%), Gaps = 60/467 (12%)
Query: 210 IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDM 268
I Y+D R Y W L++ + N IP+ + F T W+I ++ D ++L D+
Sbjct: 135 IHPYSDFRFY--WDLIMLIMMVGNLVIIPVGITF--FTEQTTTPWIIFNVASDTVFLLDL 190
Query: 269 LFIQPRLQFVRG------GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFG---- 318
+ + F G +II+D ++ +Y S F +D S IP D +L
Sbjct: 191 I-----MNFRTGTVNEDSSEIILDPKVIKMNYLKSW-FVVDFISSIPVDYIFLIVEKGMD 244
Query: 319 --------------FNPMFRANRMLKYTSFFEFNHHLESIMDKAY-----IYRVIRTTGY 359
F + R+L+ + + H E I Y + R+ G
Sbjct: 245 SEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGM 304
Query: 360 LLFILHINACVYYWASNYEGIGTTRWVY------DGEGNEYLRCYYWAVRTLITIG-GLP 412
+L + H + C+ + + WV D G +Y + A+ ++ IG G
Sbjct: 305 MLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQ 364
Query: 413 EPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIP 472
P ++ ++ +L+ G ++ +G +I + +++ ++ YM+ + +P
Sbjct: 365 APVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP 424
Query: 473 KLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---IISKVDLFKGCD 529
+++++ +YE+ + ++ DE ++L L ++ + VNF+ +++ + LF D
Sbjct: 425 ADMRQKIHDYYEHRYQG-KIFDEENILNELNDPLREEI---VNFNCRKLVATMPLFANAD 480
Query: 530 TQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSV 589
+ ML +L+ ++ PGD++ ++G +GK+MY I+HG V G + + L GS
Sbjct: 481 PNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHG---VAGVITKSSKEMKLTDGSY 537
Query: 590 FGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636
FGEI LL G RRTA+V A + L +L E+L YP R
Sbjct: 538 FGEICLLTKG---RRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 581
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 113 bits (283), Expect = 6e-25
Identities = 103/504 (20%), Positives = 212/504 (42%), Gaps = 57/504 (11%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280
W++L+ Y +P + F +T N WL+ D I D+I+L D++
Sbjct: 222 WIILILTFYT--AILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
Query: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----GFNPMFRANRMLKYTSFFE 336
G++I D +R +Y T F +D+ S +P+D+ F G + +F + ++++
Sbjct: 278 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYE-------GIGTTRWVY-- 387
L+ ++ V+ + L H AC++Y +YE I W+Y
Sbjct: 337 VARKLDHYIEYGAAVLVLLVCVFGL-AAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 395
Query: 388 ----------DGEGNE-----------YLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLL 425
+G G+ Y+ Y+ + +L ++G G P T E +F +
Sbjct: 396 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 455
Query: 426 NFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEY 485
G +++++ G + + AN N + ++ ++ Y +PK + +RV +
Sbjct: 456 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 515
Query: 486 TWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLY 545
TW R +D +L+ P ++ + + +N + + F+ + + + ++V
Sbjct: 516 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 575
Query: 546 LPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRT 605
PGD + GE + + G ++V+ +V+ L G VFG++ A +
Sbjct: 576 APGDLIYHAGESVDSLCFVVSGSLEVI---QDDEVVAILGKGDVFGDVFWKEATLA-QSC 631
Query: 606 ANVVAHGFANLLTLDKKTLQEILVHYPD-----SERILMK---KARVLLKQ----KAKTA 653
ANV A + +L + + LQ++L Y S +++ + R++ ++ K +
Sbjct: 632 ANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEE 691
Query: 654 EATPPRKDLALLFPPKEETPKLFK 677
E + + L+ PP +LF+
Sbjct: 692 ERMKRKNEAPLILPPDHPVRRLFQ 715
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 107 bits (268), Expect = 3e-23
Identities = 94/449 (20%), Positives = 191/449 (42%), Gaps = 52/449 (11%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280
W++L+ Y +P + F +T N WL+ D + D+I+L D++ G
Sbjct: 219 WVILILTFYT--AIMVPYNVSF--KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
Query: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----GFNPMFRANRMLKYTSFFE 336
G++I D +R +Y T F +D+ S +P+DI F G + +F + ++++
Sbjct: 275 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 333
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR-------WVYD- 388
L+ ++ V+ + L + H AC++Y +YE I W+Y
Sbjct: 334 VARKLDHYLEYGAAVLVLLVCVFGL-VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 392
Query: 389 ---------------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLN 426
+ + Y+ Y+ + +L TIG G P T E +F +
Sbjct: 393 ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAM 452
Query: 427 FFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYT 486
G +++++ G + + AN N + +++ ++ Y +PK + +RV + T
Sbjct: 453 MMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVST 512
Query: 487 WDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYL 546
W + +D +L P ++ + + +N + ++ F+ + + + +++
Sbjct: 513 WSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCA 572
Query: 547 PGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEI----SLLAAGGGN 602
PGD + GE + + G ++V+ +V+ L G VFG+I + LA
Sbjct: 573 PGDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA----- 624
Query: 603 RRTANVVAHGFANLLTLDKKTLQEILVHY 631
ANV A + +L + ++ L ++L Y
Sbjct: 625 HACANVRALTYCDLHIIKREALLKVLDFY 653
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 107 bits (268), Expect = 3e-23
Identities = 94/449 (20%), Positives = 191/449 (42%), Gaps = 52/449 (11%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280
W++L+ Y +P + F +T N WL+ D + D+I+L D++ G
Sbjct: 161 WVILILTFYT--AIMVPYNVSF--KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 216
Query: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----GFNPMFRANRMLKYTSFFE 336
G++I D +R +Y T F +D+ S +P+DI F G + +F + ++++
Sbjct: 217 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 275
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR-------WVYD- 388
L+ ++ V+ + L + H AC++Y +YE I W+Y
Sbjct: 276 VARKLDHYLEYGAAVLVLLVCVFGL-VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 334
Query: 389 ---------------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLN 426
+ + Y+ Y+ + +L TIG G P T E +F +
Sbjct: 335 ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAM 394
Query: 427 FFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYT 486
G +++++ G + + AN N + +++ ++ Y +PK + +RV + T
Sbjct: 395 MMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVST 454
Query: 487 WDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYL 546
W + +D +L P ++ + + +N + ++ F+ + + + +++
Sbjct: 455 WSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCA 514
Query: 547 PGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEI----SLLAAGGGN 602
PGD + GE + + G ++V+ +V+ L G VFG+I + LA
Sbjct: 515 PGDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA----- 566
Query: 603 RRTANVVAHGFANLLTLDKKTLQEILVHY 631
ANV A + +L + ++ L ++L Y
Sbjct: 567 HACANVRALTYCDLHIIKREALLKVLDFY 595
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 103 bits (256), Expect = 8e-22
Identities = 103/531 (19%), Positives = 212/531 (39%), Gaps = 84/531 (15%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280
W++L+ Y +P + F +T N WL+ D I D+I+L D++
Sbjct: 222 WIILILTFYT--AILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
Query: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----------------------- 317
G++I D +R +Y T F +D+ S +P+D+ F
Sbjct: 278 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPP 336
Query: 318 --------GFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINAC 369
G + +F + ++++ L+ ++ V+ + L H AC
Sbjct: 337 PLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGL-AAHWMAC 395
Query: 370 VYYWASNYE-------GIGTTRWVY------------DGEGNE-----------YLRCYY 399
++Y +YE I W+Y +G G+ Y+ Y
Sbjct: 396 IWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLY 455
Query: 400 WAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRAC 458
+ + +L ++G G P T E +F + G +++++ G + + AN N +
Sbjct: 456 FTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEM 515
Query: 459 MDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSI 518
++ ++ Y +PK + +RV + TW R +D +L+ P ++ + + +N +
Sbjct: 516 LNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKV 575
Query: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578
+ F+ + + + ++V PGD + GE + + G ++V+
Sbjct: 576 FKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI---QDD 632
Query: 579 KVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPD----- 633
+V+ L G VFG++ A + ANV A + +L + + LQ++L Y
Sbjct: 633 EVVAILGKGDVFGDVFWKEATLA-QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF 691
Query: 634 SERILMK---KARVLLKQ----KAKTAEATPPRKDLALLFPPKEETPKLFK 677
S +++ + R++ ++ K + E + + L+ PP +LF+
Sbjct: 692 SRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQ 742
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 102 bits (255), Expect = 1e-21
Identities = 132/666 (19%), Positives = 264/666 (39%), Gaps = 72/666 (10%)
Query: 133 HNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKV 192
++ + ++ Q T + + E SSP P + K P VK+ TE ++L
Sbjct: 326 YSTINKIPQLTLNFSEVKTEKKNSSP---PSSDKTIIAPKVKDRTHNVTEKVTQVLSLGA 382
Query: 193 KKMPLTEYLKRIKLPNSIDSYTDRLY----LLWLLLVTLAYNWNCCFIPLRLVFPYQTAD 248
+P EY +++ P I+ +T Y +W L+ L + F P F +
Sbjct: 383 DVLP--EY--KLQTPR-INKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDRE 437
Query: 249 ---------NIHYWLIADIICDIIYLYDMLFIQPRLQFV-RGGDIIVDSNELRKHYRTST 298
+ + D+I DI+++ D+L I R +V + +++ D ++ HY
Sbjct: 438 EQKRRECGYSCSPLNVVDLIVDIMFIIDIL-INFRTTYVNQNEEVVSDPAKIAIHYFKGW 496
Query: 299 KFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTG 358
F +D+ + IPFD+ G + +LK + + +
Sbjct: 497 -FLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLL 555
Query: 359 YLLFIL--HINACVYYWASNYEGIGTTRWV--YDGEGNE-------------------YL 395
+F L H AC++Y N E T + D G + Y+
Sbjct: 556 MCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYV 615
Query: 396 RCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNY 454
Y+ +L ++G G P T E +F + G +++S+ G + +I +
Sbjct: 616 TALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 675
Query: 455 FRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDV 514
+ M ++ + IP +++R+ ++++ W +D + +LK P +Q + + +
Sbjct: 676 YHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHL 735
Query: 515 NFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGG 574
N +++ F+G + + ++ K+ PGD + G++ +Y + G +++L
Sbjct: 736 NQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEIL-- 793
Query: 575 PDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDS 634
V+ L +FGE+ L A G + A+V A + +L + ++ L E+L YP+
Sbjct: 794 -KDDIVVAILGKNDIFGEMVHLYAKPG-KSNADVRALTYCDLHKIQREDLLEVLDMYPEF 851
Query: 635 ERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKL 694
+ + + ++A+A R +++ G R KL
Sbjct: 852 SDHFLTNLELTFNLRHESAKADLLRS----------------QSMNDSEGDNCKLRRRKL 895
Query: 695 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRP 754
E + KENS E ++ D + + ++ E+K + + E+KPL
Sbjct: 896 SFESEGE-KENSTNDPE---DSADTIRHYQSSKRHFEEKKSRSSSFISSIDDEQKPLFSG 951
Query: 755 ECTASP 760
+SP
Sbjct: 952 IVDSSP 957
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 99.8 bits (247), Expect = 9e-21
Identities = 106/511 (20%), Positives = 208/511 (40%), Gaps = 50/511 (9%)
Query: 160 ASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLY- 218
ASP + + P +KE TE ++L +P EY +++ P I +T Y
Sbjct: 350 ASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLP--EY--KLQAPR-IHRWTILHYS 404
Query: 219 ---LLWLLLVTLAYNWNCCFIPLRLVFPYQTADN----------IHYWLIADIICDIIYL 265
+W L+ L + F P F + + + D+I DI+++
Sbjct: 405 PFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFI 464
Query: 266 YDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFR 324
D+L I R +V + +V + HY F +D+ + IPFD+ G +
Sbjct: 465 VDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLIFGSGSEELIG 522
Query: 325 ANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGI---G 381
+ + L+ + + + L I H AC++Y N E
Sbjct: 523 LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNMEQPHMDS 581
Query: 382 TTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQ 423
W+ Y+ G ++Y+ Y+ +L ++G G P T E +F
Sbjct: 582 RIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFS 641
Query: 424 LLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWY 483
+ G +++S+ G + +I + + M ++ + IP +++R+ ++
Sbjct: 642 ICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYF 701
Query: 484 EYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSV 543
++ W +D + +LK P +Q + + +N S++ F+G + + ++ K+
Sbjct: 702 QHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTT 761
Query: 544 LYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE-ISLLAAGGGN 602
PGD + G++ +Y I G +++L G V+ L +FGE ++L A G
Sbjct: 762 HAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIFGEPLNLYARPG-- 816
Query: 603 RRTANVVAHGFANLLTLDKKTLQEILVHYPD 633
+ +V A + +L + + L E+L YP+
Sbjct: 817 KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 847
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 99.0 bits (245), Expect = 2e-20
Identities = 78/395 (19%), Positives = 166/395 (42%), Gaps = 40/395 (10%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280
W++L+ Y +P + F +T N WL+ D + D+I+L D++ G
Sbjct: 219 WVILILTFYT--AIMVPYNVSF--KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
Query: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----GFNPMFRANRMLKYTSFFE 336
G++I D +R +Y T F +D+ S +P+DI F G + +F + ++++
Sbjct: 275 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 333
Query: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR-------WVYD- 388
L+ ++ V+ + L + H AC++Y +YE I W+Y
Sbjct: 334 VARKLDHYLEYGAAVLVLLVCVFGL-VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 392
Query: 389 ---------------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLN 426
+ + Y+ Y+ + +L TIG G P T E +F +
Sbjct: 393 ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAM 452
Query: 427 FFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYT 486
G +++++ G + + AN N + +++ ++ Y +PK + +RV + T
Sbjct: 453 MMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVST 512
Query: 487 WDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYL 546
W + +D +L P ++ + + +N + ++ F+ + + + +++
Sbjct: 513 WSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCA 572
Query: 547 PGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVL 581
PGD + GE + + G ++V+ + +L
Sbjct: 573 PGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 94.7 bits (234), Expect = 3e-19
Identities = 84/402 (20%), Positives = 171/402 (42%), Gaps = 31/402 (7%)
Query: 255 IADIICDIIYLYDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDIC 313
+ D+I DI+++ D+L I R +V + +V + HY F +D+ + IPFD+
Sbjct: 114 VVDLIVDIMFIVDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLL 171
Query: 314 YLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYW 373
G + + + L+ + + + L I H AC++Y
Sbjct: 172 IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYA 230
Query: 374 ASNYEGI---GTTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLP 412
N E W+ Y+ G ++Y+ Y+ +L ++G G
Sbjct: 231 IGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNV 290
Query: 413 EPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIP 472
P T E +F + G +++S+ G + +I + + M ++ + IP
Sbjct: 291 SPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIP 350
Query: 473 KLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQM 532
+++R+ ++++ W +D + +LK P +Q + + +N S++ F+G
Sbjct: 351 NPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGC 410
Query: 533 IYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE 592
+ + ++ K+ PGD + G++ +Y I G +++L G V+ L +FGE
Sbjct: 411 LRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL---RGDVVVAILGKNDIFGE 467
Query: 593 -ISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPD 633
++L A G + +V A + +L + + L E+L YP+
Sbjct: 468 PLNLYARPG--KSNGDVRALTYCDLHKIHRDDLLEVLDMYPE 507
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 91.7 bits (226), Expect = 3e-18
Identities = 97/485 (20%), Positives = 206/485 (42%), Gaps = 52/485 (10%)
Query: 178 DKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCCFIP 237
DKP Y++ K K L + ++ + D L LL V + +N CFI
Sbjct: 195 DKPAFPEYKVSDAKKSKFILLHF-------STFKAGWDWLILLATFYVAVTVPYNVCFIG 247
Query: 238 LRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTS 297
++DI +I+++ D++ + G +I ++ + HY T
Sbjct: 248 ------NDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT- 300
Query: 298 TKFQLDVASIIPFDICYLF----FGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRV 353
T F +D+ + +PFD+ Y F + + R+L+ + L+ + I
Sbjct: 301 TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQ---KLDRYSQHSTIVLT 357
Query: 354 IRTTGYLLFILHINACVYYWASNYEGIGTT------RWVYD-GE-------GNE------ 393
+ + + L + H AC++Y E + W+++ G+ GN
Sbjct: 358 LLMSMFAL-LAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPS 416
Query: 394 ----YLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAA 448
Y+ Y+ + +L ++G G T E +F + G + + + G + +I
Sbjct: 417 IRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRM 476
Query: 449 TANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQL 508
+ + + D ++ + +P+ +++R+ +++ TW +D ++LLK P ++
Sbjct: 477 YSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRS 536
Query: 509 ALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGE 568
+ + +N I+ ++ LF+ + + L +K+ PG+++ ++G+ + +Y + G
Sbjct: 537 DITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGS 595
Query: 569 VQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628
++VL + VL L G + G +L + A+V A + +L + K L E+L
Sbjct: 596 MEVL---KDSMVLAILGKGDLIG-ANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVL 651
Query: 629 VHYPD 633
YP+
Sbjct: 652 DLYPE 656
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 89.0 bits (219), Expect = 2e-17
Identities = 90/451 (19%), Positives = 180/451 (39%), Gaps = 44/451 (9%)
Query: 160 ASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLY- 218
ASP + + P +KE TE ++L +P EY +++ P I +T Y
Sbjct: 350 ASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLP--EY--KLQAPR-IHRWTILHYS 404
Query: 219 ---LLWLLLVTLAYNWNCCFIPLRLVFPYQTADN----------IHYWLIADIICDIIYL 265
+W L+ L + F P F + + + D+I DI+++
Sbjct: 405 PFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFI 464
Query: 266 YDMLFIQPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFR 324
D+L I R +V + +V + HY F +D+ + IPFD+ G +
Sbjct: 465 VDIL-INFRTTYVNANEEVVSHPGRIAVHYFKGW-FLIDMVAAIPFDLLIFGSGSEELIG 522
Query: 325 ANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGI---G 381
+ + L+ + + + L I H AC++Y N E
Sbjct: 523 LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFAL-IAHWLACIWYAIGNMEQPHMDS 581
Query: 382 TTRWV----------YDGEG-------NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQ 423
W+ Y+ G ++Y+ Y+ +L ++G G P T E +F
Sbjct: 582 RIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFS 641
Query: 424 LLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWY 483
+ G +++S+ G + +I + + M ++ + IP +++R+ ++
Sbjct: 642 ICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYF 701
Query: 484 EYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSV 543
++ W +D + +LK P +Q + + +N S++ F+G + + ++ K+
Sbjct: 702 QHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTT 761
Query: 544 LYLPGDFVCKKGEIGKEMYIIKHGEVQVLGG 574
PGD + G++ +Y I G +++L G
Sbjct: 762 HAPPGDTLVHAGDLLTALYFISRGSIEILRG 792
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 88.6 bits (218), Expect = 2e-17
Identities = 96/453 (21%), Positives = 185/453 (40%), Gaps = 56/453 (12%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWL---------IADIICDIIYLYDMLFI 271
WL+L+ + Y F P F D + D+I DI+++ D++ I
Sbjct: 261 WLILLLVIYT--AVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIV-I 317
Query: 272 QPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLK 330
R +V D +V + HY F +D+ + IPFD+ G + +LK
Sbjct: 318 NFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLIFRTGSDETTTLIGLLK 376
Query: 331 YTSFFEFNHHLESI-----MDKAYIYRVIRTTGYLLFILHINACVYYWASNYEG------ 379
+ A ++ ++ T I H AC++Y N E
Sbjct: 377 TARLLRLVRVARKLDRYSEYGAAVLFLLMCT---FALIAHWLACIWYAIGNVERPYLEHK 433
Query: 380 IGTTRWV----------YDGEG--------NEYLRCYYWAVRTLITIG-GLPEPQTLFEI 420
IG W+ Y+G ++Y+ Y+ +L ++G G P T E
Sbjct: 434 IG---WLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 490
Query: 421 VFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVR 480
VF + G +++S+ G + +I + + M ++ + IP +++R+
Sbjct: 491 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 550
Query: 481 TWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRL 540
++++ W +D + +LK P +Q + + ++ +++ F G + + ++
Sbjct: 551 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 610
Query: 541 KSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE-ISLLAAG 599
K+ PGD + G++ +Y I G +++L V+ L +FGE +SL A
Sbjct: 611 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEIL---RDDVVVAILGKNDIFGEPVSLHAQP 667
Query: 600 GGNRRTANVVAHGFANLLTLDKKTLQEILVHYP 632
G + +A+V A + +L + + L E+L YP
Sbjct: 668 G--KSSADVRALTYCDLHKIQRADLLEVLDMYP 698
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 87.4 bits (215), Expect = 5e-17
Identities = 90/454 (19%), Positives = 192/454 (42%), Gaps = 47/454 (10%)
Query: 215 DRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPR 274
D L LL V + +N CF T + L++DI +++++ D++
Sbjct: 230 DGLILLATFYVAVTVPYNVCFSG-----DDDTPITSRHTLVSDIAVEMLFILDIILNFRT 284
Query: 275 LQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSF 334
+ G +I + HY +T F +D+ + +PFD+ Y+F + +LK
Sbjct: 285 TYVSQSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFN--ITVTSLVHLLKTVRL 341
Query: 335 FEFNHHLESIMDKAYIYRVIRTTGYLLFIL--HINACVYY------WASNYEGIGTTRWV 386
L+ + + V+ T +F L H AC++Y +N + W+
Sbjct: 342 LRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWL 401
Query: 387 YD-----------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFF 428
++ + Y+ Y+ + +L ++G G T E +F +
Sbjct: 402 HELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTML 461
Query: 429 SGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWD 488
G + + + G + +I + ++ + + M D ++ + +P+ +++R+ +++ TW
Sbjct: 462 IGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWA 521
Query: 489 SQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPG 548
+D ++LL+ P ++ +A+ +N I+ ++ LF + + L +K+ PG
Sbjct: 522 VNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPG 580
Query: 549 DFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFG----EISLLAAGGGN-- 602
+++ ++G+ + Y + G ++VL VL L G + G E G +
Sbjct: 581 EYLLRRGDALQAHYYVCSGSLEVL---RDNMVLAILGKGDLIGADIPEPGQEPGLGADPN 637
Query: 603 ---RRTANVVAHGFANLLTLDKKTLQEILVHYPD 633
+ +A+V A + L L + L E+L YP+
Sbjct: 638 FVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 79.3 bits (194), Expect = 1e-14
Identities = 83/392 (21%), Positives = 169/392 (43%), Gaps = 63/392 (16%)
Query: 255 IADIICDIIYLYDMLFIQPRLQFV-RGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDIC 313
+ D+ +++++ D++ + R FV + G ++ + HY T T F LDV + +PFD+
Sbjct: 263 VCDLAVEVLFILDIV-LNFRTTFVSKSGQVVFAPKSICLHYVT-TWFLLDVIAALPFDLL 320
Query: 314 YLFFGFNPMFRANRMLKYTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFIL--HINACVY 371
+ F N F A+ +LK L + + V+ T +F L H ACV+
Sbjct: 321 HAF-KVNVYFGAH-LLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVW 378
Query: 372 YW-------------------------------------------------ASNYEGIGT 382
++ +S+ E GT
Sbjct: 379 FYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEANGT 438
Query: 383 TRWVYDGEG--NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIG 439
+ G + Y+ Y+A+ +L ++G G T E +F + G + + + G
Sbjct: 439 GLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFG 498
Query: 440 QMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLL 499
+ +I A + + + D Y+ + IPK +++R+ +++ TW +D ++LL
Sbjct: 499 NVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELL 558
Query: 500 KTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGK 559
++LP ++ +A+ ++ ++ ++ LF+ + + L L+ PG+++ +G+ +
Sbjct: 559 QSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQ 617
Query: 560 EMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFG 591
+Y + G ++VL G GT VL L G + G
Sbjct: 618 ALYFVCSGSMEVLKG--GT-VLAILGKGDLIG 646
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 79.3 bits (194), Expect = 1e-14
Identities = 86/424 (20%), Positives = 172/424 (40%), Gaps = 51/424 (12%)
Query: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWL---------IADIICDIIYLYDMLFI 271
WL+L+ + Y F P F D + D+I DI+++ D++ I
Sbjct: 261 WLILLLVIYT--AVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIV-I 317
Query: 272 QPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLK 330
R +V D +V + HY F +D+ + IPFD+ G + +LK
Sbjct: 318 NFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLIFRTGSDETTTLIGLLK 376
Query: 331 YTSFFEFNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGE 390
++ R + Y +L + C + +++
Sbjct: 377 TARLLRLVRVAR---------KLDRYSEYGAAVLFLLMCTFALIAHW------------- 414
Query: 391 GNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAAT 449
L C + +L ++G G P T E VF + G +++S+ G + +I
Sbjct: 415 ----LAC----ICSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLY 466
Query: 450 ANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLA 509
+ + M ++ + IP +++R+ ++++ W +D + +LK P +Q
Sbjct: 467 SGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQAD 526
Query: 510 LAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEV 569
+ + ++ +++ F G + + ++ K+ PGD + G++ +Y I G +
Sbjct: 527 ICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSI 586
Query: 570 QVLGGPDGTKVLVTLKAGSVFGE-ISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628
++L V+ L +FGE +SL A G + +A+V A + +L + + L E+L
Sbjct: 587 EIL---RDDVVVAILGKNDIFGEPVSLHAQPG--KSSADVRALTYCDLHKIQRADLLEVL 641
Query: 629 VHYP 632
YP
Sbjct: 642 DMYP 645
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 58.2 bits (139), Expect = 3e-08
Identities = 41/155 (26%), Positives = 77/155 (49%), Gaps = 5/155 (3%)
Query: 640 KKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQA 699
K+ + +K K + + P L L PPKE LF A L LL + E+
Sbjct: 632 KREKEKVKDKGREDKMKAPAPPLVL--PPKELALPLFSPATASRVPAMLPSLLPVLPEKL 689
Query: 700 AQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTAS 759
++KE + E++ + E K+K+ ++K+K+ +++ KE +++K RE E++ +
Sbjct: 690 FEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREK-REKEKEKHKHEKIKVE 748
Query: 760 PIAVEEEPHSVRRTVLPRGTSRQSLIIS-MAPSAE 793
P+A+ P + R L G + ++IS + P+ E
Sbjct: 749 PVALAPSP-VIPRLTLRVGAGQDKIVISKVVPAPE 782
Score = 37.4 bits (85), Expect = 0.056
Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 11/106 (10%)
Query: 644 VLLKQKAKTAEATPPR----KDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQA 699
V+ K K T PP ++ P E K+++ + + LK + +
Sbjct: 473 VVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTK 532
Query: 700 AQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGRE 745
+KKE E E +N+DK KE +DK KE E +DK+ GRE
Sbjct: 533 MKKKEKQRDREREKDKNKDKSKE-KDKVKEKE------KDKETGRE 571
Score = 35.8 bits (81), Expect = 0.16
Identities = 30/113 (26%), Positives = 53/113 (46%), Gaps = 10/113 (8%)
Query: 697 EQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPEC 756
E K + +G + KE +K++ +K K+++DK ++ + KDKGRE D+ +
Sbjct: 596 EDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGRE------DKMKA 649
Query: 757 TASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPSAEGGEEVLTIEVKEKAKQ 809
A P+ + P + + T+ S + +M PS E KEK K+
Sbjct: 650 PAPPLVL--PPKELALPLFSPATA--SRVPAMLPSLLPVLPEKLFEEKEKVKE 698
>gi|66792814 retrotransposon gag domain containing 4 [Homo sapiens]
Length = 569
Score = 55.5 bits (132), Expect = 2e-07
Identities = 27/73 (36%), Positives = 44/73 (60%)
Query: 695 KREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRP 754
K E+ +K+E E EEE K+ E++++ ++E E K +E+ED+D G++PE +P P
Sbjct: 383 KEEEMKKKEEKEEEEEEEMKQKEEEEEIRNKNEEEGESKDEEDEDEDGGQKPEGEPQQDP 442
Query: 755 ECTASPIAVEEEP 767
+ VEEEP
Sbjct: 443 GTEETYGEVEEEP 455
Score = 37.0 bits (84), Expect = 0.073
Identities = 16/60 (26%), Positives = 37/60 (61%)
Query: 696 REQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPE 755
R + +++ ++E KE E+++ + E++ K+ E+K +E E++ K +E EE+ ++ E
Sbjct: 356 RLHSKDQRKRMRAFQQEMKEKEEEEMKKEEEMKKKEEKEEEEEEEMKQKEEEEEIRNKNE 415
Score = 36.2 bits (82), Expect = 0.13
Identities = 32/153 (20%), Positives = 62/153 (40%), Gaps = 11/153 (7%)
Query: 17 NNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKK 76
+ + +Q +RR+ S + + QE + EE+ +K + EE ++++ +K
Sbjct: 345 SEDEDQEARRHRLHSKDQRKRMRAFQQEMKEKEEEEMKKEEEMKKKEEKEEEEEEEMKQK 404
Query: 77 NSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVINEYADAQLHNLV 136
++ +N E E ++ D G++ PQ P E + L
Sbjct: 405 EEEEEIRN----KNEEEGESKDEEDEDEDGGQKPEGEPQQDPGTEETYGEVEEEPLDE-- 458
Query: 137 KRMRQRTALYKKKLVEGDLSSPEASPQTAKPTA 169
Q L +L+E + + AS QT+ PT+
Sbjct: 459 ---AQDDDL--DELMEMEPTFVHASSQTSGPTS 486
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 692 LKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPL 751
+K K E+ + +N E GE + +E+ED+ + + + +D G E + E EE+PL
Sbjct: 401 MKQKEEEEEIRNKNEEEGESKDEEDEDEDGGQKPEGEPQQDPGTE----ETYGEVEEEPL 456
Query: 752 DRPECTASPIAVEEEP 767
D + +E EP
Sbjct: 457 DEAQDDDLDELMEMEP 472
>gi|5453978 protein kinase, cGMP-dependent, type II [Homo sapiens]
Length = 762
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/110 (28%), Positives = 55/110 (50%), Gaps = 6/110 (5%)
Query: 519 ISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGT 578
++K K D Q I DM+ + Y G ++ K+GE G ++++ G ++V G
Sbjct: 163 LNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVF---QGE 219
Query: 579 KVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEIL 628
K+L ++ + FGE+++L RTA+V A LD++ Q I+
Sbjct: 220 KLLSSIPMWTTFGELAILY---NCTRTASVKAITNVKTWALDREVFQNIM 266
Score = 46.6 bits (109), Expect = 9e-05
Identities = 31/126 (24%), Positives = 65/126 (51%), Gaps = 7/126 (5%)
Query: 517 SIISKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQV---LG 573
+ + V L K + ++ L+ Y GD++ ++GE G +I+ G+V+V
Sbjct: 279 NFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTE 338
Query: 574 GPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVA-HGFANLLTLDKKTLQEILVHYP 632
G D +++ TL+ G FGE +L++ + R+AN++A L +D++T + + +
Sbjct: 339 GHDQPQLIKTLQKGEYFGEKALIS---DDVRSANIIAEENDVACLVIDRETFNQTVGTFE 395
Query: 633 DSERIL 638
+ ++ L
Sbjct: 396 ELQKYL 401
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/164 (20%), Positives = 75/164 (45%), Gaps = 20/164 (12%)
Query: 626 EILVHYPDSERILMKKARVLLKQKAKTAE-----ATPPRKDLALLFPPKEETPKLFKTLL 680
E+L +P+ + +L + L + T+ A P + FP ++ K +
Sbjct: 270 EVLESFPEEDSVLSHSS---LSSPSSTSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKFV 326
Query: 681 GGTGKASLARL------------LKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQK 728
G+ + + RL L+ +RE+ + KE ++ +EE K+ ++++KE ++K++
Sbjct: 327 KGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKER 386
Query: 729 ENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRR 772
+ + E E +K R EE+ +R E + + + + +R
Sbjct: 387 REKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKR 430
Score = 35.8 bits (81), Expect = 0.16
Identities = 21/73 (28%), Positives = 38/73 (52%), Gaps = 8/73 (10%)
Query: 693 KLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKEN--------EDKGKENEDKDKGR 744
K + E+ ++KE E E++ KE +KQ+ E+++KE E+K K+ E+K
Sbjct: 374 KKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLRE 433
Query: 745 EPEEKPLDRPECT 757
E + ++ E T
Sbjct: 434 EEKRIKAEKAEIT 446
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,254,256
Number of Sequences: 37866
Number of extensions: 1609169
Number of successful extensions: 24086
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 463
Number of HSP's successfully gapped in prelim test: 506
Number of HSP's that attempted gapping in prelim test: 12922
Number of HSP's gapped (non-prelim): 7727
length of query: 809
length of database: 18,247,518
effective HSP length: 110
effective length of query: 699
effective length of database: 14,082,258
effective search space: 9843498342
effective search space used: 9843498342
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.