Guide to the Human Genome
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Search of human proteins with 23943900

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23943900 transmembrane channel-like 8 [Homo sapiens]
         (726 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23943900 transmembrane channel-like 8 [Homo sapiens]              1476   0.0  
gi|238550098 transmembrane channel-like 7 isoform a [Homo sapiens]    366   e-101
gi|238550100 transmembrane channel-like 7 isoform b [Homo sapiens]    363   e-100
gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens]     332   1e-90
gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens]    332   1e-90
gi|157426860 transmembrane channel-like 5 isoform a [Homo sapiens]    197   3e-50
gi|31377679 transmembrane channel-like 5 isoform c [Homo sapiens]     197   3e-50
gi|157426862 transmembrane channel-like 5 isoform b [Homo sapiens]    187   3e-47
gi|187608784 transmembrane channel-like 6 [Homo sapiens]              171   2e-42
gi|187608791 transmembrane channel-like 6 [Homo sapiens]              171   2e-42
gi|94536852 transmembrane cochlear-expressed protein 2 [Homo sap...   154   4e-37
gi|21071070 transmembrane channel-like 1 [Homo sapiens]               152   1e-36
gi|122937502 transmembrane channel-like 3 [Homo sapiens]              108   1e-23
gi|119829187 alpha 1 type XVII collagen [Homo sapiens]                 40   0.008
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     39   0.013
gi|56606142 complement component 1, q subcomponent-like 4 [Homo ...    39   0.017
gi|134244285 Notch homolog 3 [Homo sapiens]                            38   0.029
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      38   0.038
gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]          37   0.050
gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo sa...    37   0.084
gi|116256356 alpha 4 type IV collagen precursor [Homo sapiens]         37   0.084
gi|195972903 zinc finger protein 385A isoform a [Homo sapiens]         37   0.084
gi|24308079 zinc finger protein 385A isoform c [Homo sapiens]          37   0.084
gi|32964830 collagen, type VIII, alpha 2 [Homo sapiens]                36   0.11 
gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]                 36   0.11 
gi|7662302 TBK1 binding protein 1 [Homo sapiens]                       36   0.14 
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]              35   0.19 
gi|194294532 alpha 1 type XIII collagen isoform 20 [Homo sapiens]      35   0.19 
gi|22027609 alpha 1 type XIII collagen isoform 19 [Homo sapiens]       35   0.19 
gi|22027607 alpha 1 type XIII collagen isoform 18 [Homo sapiens]       35   0.19 

>gi|23943900 transmembrane channel-like 8 [Homo sapiens]
          Length = 726

 Score = 1476 bits (3820), Expect = 0.0
 Identities = 726/726 (100%), Positives = 726/726 (100%)

Query: 1   MLLPRSVSSERAPGVPEPEELWEAEMERLRGSGTPVRGLPYAMMDKRLIWQLREPAGVQT 60
           MLLPRSVSSERAPGVPEPEELWEAEMERLRGSGTPVRGLPYAMMDKRLIWQLREPAGVQT
Sbjct: 1   MLLPRSVSSERAPGVPEPEELWEAEMERLRGSGTPVRGLPYAMMDKRLIWQLREPAGVQT 60

Query: 61  LRWQRWQRRRQTVERRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLN 120
           LRWQRWQRRRQTVERRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLN
Sbjct: 61  LRWQRWQRRRQTVERRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLN 120

Query: 121 LLSLLLTASFVLLPLVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFT 180
           LLSLLLTASFVLLPLVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFT
Sbjct: 121 LLSLLLTASFVLLPLVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFT 180

Query: 181 NTYLFYGAYRVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQA 240
           NTYLFYGAYRVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQA
Sbjct: 181 NTYLFYGAYRVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQA 240

Query: 241 PLSAKVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYL 300
           PLSAKVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYL
Sbjct: 241 PLSAKVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYL 300

Query: 301 RVNVLNGLLVVGAISAIFWATKYSQDNKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQ 360
           RVNVLNGLLVVGAISAIFWATKYSQDNKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQ
Sbjct: 301 RVNVLNGLLVVGAISAIFWATKYSQDNKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQ 360

Query: 361 LENYPPNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWE 420
           LENYPPNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWE
Sbjct: 361 LENYPPNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWE 420

Query: 421 NSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVA 480
           NSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVA
Sbjct: 421 NSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVA 480

Query: 481 GQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLL 540
           GQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLL
Sbjct: 481 GQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLL 540

Query: 541 GLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFS 600
           GLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFS
Sbjct: 541 GLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFS 600

Query: 601 FPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPG 660
           FPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPG
Sbjct: 601 FPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPG 660

Query: 661 PKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASARRFRF 720
           PKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASARRFRF
Sbjct: 661 PKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASARRFRF 720

Query: 721 PSGAEL 726
           PSGAEL
Sbjct: 721 PSGAEL 726


>gi|238550098 transmembrane channel-like 7 isoform a [Homo sapiens]
          Length = 723

 Score =  366 bits (940), Expect = e-101
 Identities = 220/638 (34%), Positives = 352/638 (55%), Gaps = 30/638 (4%)

Query: 32  SGTPVRGLPYAMMDKRLIWQLREPAGVQTLRWQRWQRRRQTVERRLREAAQRLARGLGLW 91
           S   +R     + +KR +  ++E        W +W+R      +R  E A+ +   L LW
Sbjct: 86  SSHSLRNYALNISEKRRLRDIQETQMKYLSEWDQWKRYSSKSWKRFLEKAREMTTHLELW 145

Query: 92  EGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPG------P 145
              +  I G FGTGI+SYF+FLRFL+LLNL+  L+    VLLP++  +           P
Sbjct: 146 REDIRSIEGKFGTGIQSYFSFLRFLVLLNLVIFLIIFMLVLLPVLLTKYKITNSSFVLIP 205

Query: 146 TLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTN-TYLFYGAYRVGPES--SSVYSIR 202
             ++  QC     S  G++ F++ +  +L+G  F   T LFYG Y +      +  Y + 
Sbjct: 206 FKDMDKQCTVYPVSSSGLIYFYSYIIDLLSGTGFLEETSLFYGHYTIDGVKFQNFTYDLP 265

Query: 203 LAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATI 262
           LAYLLS +A L L     ++R V+G     +  + +      K+F+ WDFCI  +  A +
Sbjct: 266 LAYLLSTIASLALSLLWIVKRSVEGFKINLIRSEEHFQSYCNKIFAGWDFCITNRSMADL 325

Query: 263 KKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLVVGAISAIFWATK 322
           K   +  E + +LEE R  Q + ++T  +T       L +N +   ++     AI+ AT 
Sbjct: 326 KHSSLRYELRADLEEERMRQKIAERTSEETIRIYSLRLFLNCIVLAVLGACFYAIYVATV 385

Query: 323 YSQDNKE---------ESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLT 373
           +SQ++ +         E+LF+L  YLP  VI L NF+ P++F  +++ E+Y P  E+ LT
Sbjct: 386 FSQEHMKKEIDKMVFGENLFIL--YLPSIVITLANFITPMIFAKIIRYEDYSPGFEIRLT 443

Query: 374 LIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWENSVGEELYKLSIF 433
           ++ CV ++LA++ +   +LG  I     D  +C+  GYN   Y CWE  VG+E+YKL IF
Sbjct: 444 ILRCVFMRLATICVLVFTLGSKITSC--DDDTCDLCGYNQKLYPCWETQVGQEMYKLMIF 501

Query: 434 NFLLTVAFAFLVTLPRRLLVDRFSG----RFWAWLEREEFLVPKNVLDIVAGQTVTWMGL 489
           +F++ +A    V  PR+LLV   S     + W    ++EF +P NVL IV GQT+ W+G 
Sbjct: 502 DFIIILAVTLFVDFPRKLLVTYCSSCKLIQCWG---QQEFAIPDNVLGIVYGQTICWIGA 558

Query: 490 FYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLLGLLLAAVPL 549
           F+ PLLP + ++   + FY+K+++LL   R S RPFRAS+S FFF LVLL+GL LA +PL
Sbjct: 559 FFSPLLPAIATLKFIIIFYVKEWSLLYTCRPSPRPFRASNSNFFFLLVLLIGLCLAIIPL 618

Query: 550 GYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFSFPLLIMLSL 609
              +S I SS  CG FTN++  W+V+P+ V+   P   Q  +H + S AF+ P  +++ L
Sbjct: 619 TISISRIPSSKACGPFTNFNTTWEVIPKTVST-FPSSLQSFIHGVTSEAFAVPFFMIICL 677

Query: 610 VLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLS 647
           ++   ++   A+ R + +LR+QL  + ++K +L++ L+
Sbjct: 678 IMFYFIALAGAHKRVVIQLREQLSLESRDKCYLIQKLT 715


>gi|238550100 transmembrane channel-like 7 isoform b [Homo sapiens]
          Length = 613

 Score =  363 bits (932), Expect = e-100
 Identities = 215/607 (35%), Positives = 341/607 (56%), Gaps = 30/607 (4%)

Query: 63  WQRWQRRRQTVERRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLL 122
           W +W+R      +R  E A+ +   L LW   +  I G FGTGI+SYF+FLRFL+LLNL+
Sbjct: 7   WDQWKRYSSKSWKRFLEKAREMTTHLELWREDIRSIEGKFGTGIQSYFSFLRFLVLLNLV 66

Query: 123 SLLLTASFVLLPLVWLRPPDPG------PTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTG 176
             L+    VLLP++  +           P  ++  QC     S  G++ F++ +  +L+G
Sbjct: 67  IFLIIFMLVLLPVLLTKYKITNSSFVLIPFKDMDKQCTVYPVSSSGLIYFYSYIIDLLSG 126

Query: 177 RAFTN-TYLFYGAYRVGPES--SSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTL 233
             F   T LFYG Y +      +  Y + LAYLLS +A L L     ++R V+G     +
Sbjct: 127 TGFLEETSLFYGHYTIDGVKFQNFTYDLPLAYLLSTIASLALSLLWIVKRSVEGFKINLI 186

Query: 234 LGQGYQAPLSAKVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTA 293
             + +      K+F+ WDFCI  +  A +K   +  E + +LEE R  Q + ++T  +T 
Sbjct: 187 RSEEHFQSYCNKIFAGWDFCITNRSMADLKHSSLRYELRADLEEERMRQKIAERTSEETI 246

Query: 294 CRLLSYLRVNVLNGLLVVGAISAIFWATKYSQDNKE---------ESLFLLLQYLPPGVI 344
                 L +N +   ++     AI+ AT +SQ++ +         E+LF+L  YLP  VI
Sbjct: 247 RIYSLRLFLNCIVLAVLGACFYAIYVATVFSQEHMKKEIDKMVFGENLFIL--YLPSIVI 304

Query: 345 ALVNFLGPLLFTFLVQLENYPPNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKS 404
            L NF+ P++F  +++ E+Y P  E+ LT++ CV ++LA++ +   +LG  I     D  
Sbjct: 305 TLANFITPMIFAKIIRYEDYSPGFEIRLTILRCVFMRLATICVLVFTLGSKITSC--DDD 362

Query: 405 SCESYGYNVCDYQCWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSG----RF 460
           +C+  GYN   Y CWE  VG+E+YKL IF+F++ +A    V  PR+LLV   S     + 
Sbjct: 363 TCDLCGYNQKLYPCWETQVGQEMYKLMIFDFIIILAVTLFVDFPRKLLVTYCSSCKLIQC 422

Query: 461 WAWLEREEFLVPKNVLDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRA 520
           W    ++EF +P NVL IV GQT+ W+G F+ PLLP + ++   + FY+K+++LL   R 
Sbjct: 423 WG---QQEFAIPDNVLGIVYGQTICWIGAFFSPLLPAIATLKFIIIFYVKEWSLLYTCRP 479

Query: 521 SSRPFRASSSTFFFQLVLLLGLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVA 580
           S RPFRAS+S FFF LVLL+GL LA +PL   +S I SS  CG FTN++  W+V+P+ V+
Sbjct: 480 SPRPFRASNSNFFFLLVLLIGLCLAIIPLTISISRIPSSKACGPFTNFNTTWEVIPKTVS 539

Query: 581 LGLPPIGQRALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKW 640
              P   Q  +H + S AF+ P  +++ L++   ++   A+ R + +LR+QL  + ++K 
Sbjct: 540 T-FPSSLQSFIHGVTSEAFAVPFFMIICLIMFYFIALAGAHKRVVIQLREQLSLESRDKC 598

Query: 641 HLVEDLS 647
           +L++ L+
Sbjct: 599 YLIQKLT 605


>gi|21389589 transmembrane channel-like 4 isoform 2 [Homo sapiens]
          Length = 706

 Score =  332 bits (850), Expect = 1e-90
 Identities = 225/626 (35%), Positives = 322/626 (51%), Gaps = 40/626 (6%)

Query: 35  PVRGLPYAMMDKRLIWQLREP-------AGVQTLRWQRWQRRRQTVERRLREAAQRLARG 87
           P R LP+ M  +R   Q           +G +T RW R       + RR +E  +   R 
Sbjct: 83  PSRELPWPMQARRAHRQRNASRDQVVYGSGTKTDRWAR-------LLRRSKEKTKEGLRS 135

Query: 88  LGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPGPT- 146
           L  W   L  IGG FG G  SYF+ LRFLLLLN+L+ +L A   LLP  WL    PGP  
Sbjct: 136 LQPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACMTLLP-TWLGGAPPGPPG 194

Query: 147 LNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTN-TYLFYGAYRVGPESSSVYSIRLAY 205
            +++  C        G++ F  QL+++L+G  +   + LFYG Y   P       + + Y
Sbjct: 195 PDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFYPPRPR------LAVTY 248

Query: 206 LLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKH 265
           L    A  L+C    L R V GL Q  L         S +VFS+WDF +       +++ 
Sbjct: 249 LCWAFAVGLICLLLILHRSVSGLKQTLLAESEALTSYSHRVFSAWDFGLCGDVHVRLRQR 308

Query: 266 EISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLVVGAISA----IFWAT 321
            I  E KVELEE     ++++Q   +T  +      V VL  LLVV  + A    ++WAT
Sbjct: 309 IILYELKVELEE----TVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLGAAFYGVYWAT 364

Query: 322 KYSQDNKEESLF-------LLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLTL 374
             + + +E  L        L + YLP   IA VNF+ P +F  +  LE Y  + ++   L
Sbjct: 365 GCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGYTRSRQIVFIL 424

Query: 375 IWCVVLKLASLGMFSVSLGQTILCIGRDKSS-CESYGYNVCDYQCWENSVGEELYKLSIF 433
           +  V L+LASL +   SL   I C G  ++  C++ GYN     CWE  +G+E+YKL +F
Sbjct: 425 LRTVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCGYNYKQLPCWETVLGQEMYKLLLF 484

Query: 434 NFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVTWMGLFYCP 493
           + L  +A A L+  PR+LL     G        +EF VP  VL ++  QTV W+G F+CP
Sbjct: 485 DLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCP 544

Query: 494 LLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLLGLLLAAVPLGYVV 553
           LLPLLN+V   L FY+KK TL      ++R FRAS++ FFF LVLLLGL +++VPL Y +
Sbjct: 545 LLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPLVLLLGLAISSVPLLYSI 604

Query: 554 SSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFSFPLLIMLSLVLTV 613
             I  S  CG F   S+ W  +PE ++  LP   Q  L +LG+ AF+ PLL++ S+++  
Sbjct: 605 FLIPPSKLCGPFRGQSSIWAQIPESIS-SLPETTQNFLFFLGTQAFAVPLLLISSILMAY 663

Query: 614 CVSQTQANARAIHRLRKQLVWQVQEK 639
            V+   +  R I  L++Q   + Q K
Sbjct: 664 TVALANSYGRLISELKRQRQTEAQNK 689


>gi|223718080 transmembrane channel-like 4 isoform 1 [Homo sapiens]
          Length = 712

 Score =  332 bits (850), Expect = 1e-90
 Identities = 225/626 (35%), Positives = 322/626 (51%), Gaps = 40/626 (6%)

Query: 35  PVRGLPYAMMDKRLIWQLREP-------AGVQTLRWQRWQRRRQTVERRLREAAQRLARG 87
           P R LP+ M  +R   Q           +G +T RW R       + RR +E  +   R 
Sbjct: 89  PSRELPWPMQARRAHRQRNASRDQVVYGSGTKTDRWAR-------LLRRSKEKTKEGLRS 141

Query: 88  LGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPGPT- 146
           L  W   L  IGG FG G  SYF+ LRFLLLLN+L+ +L A   LLP  WL    PGP  
Sbjct: 142 LQPWAWTLKRIGGQFGAGTESYFSLLRFLLLLNVLASVLMACMTLLP-TWLGGAPPGPPG 200

Query: 147 LNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTN-TYLFYGAYRVGPESSSVYSIRLAY 205
            +++  C        G++ F  QL+++L+G  +   + LFYG Y   P       + + Y
Sbjct: 201 PDISSPCGSYNPHSQGLVTFATQLFNLLSGEGYLEWSPLFYGFYPPRPR------LAVTY 254

Query: 206 LLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKH 265
           L    A  L+C    L R V GL Q  L         S +VFS+WDF +       +++ 
Sbjct: 255 LCWAFAVGLICLLLILHRSVSGLKQTLLAESEALTSYSHRVFSAWDFGLCGDVHVRLRQR 314

Query: 266 EISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLVVGAISA----IFWAT 321
            I  E KVELEE     ++++Q   +T  +      V VL  LLVV  + A    ++WAT
Sbjct: 315 IILYELKVELEE----TVVRRQAAVRTLGQQARVWLVRVLLNLLVVALLGAAFYGVYWAT 370

Query: 322 KYSQDNKEESLF-------LLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLTL 374
             + + +E  L        L + YLP   IA VNF+ P +F  +  LE Y  + ++   L
Sbjct: 371 GCTVELQEMPLVQELPLLKLGVNYLPSIFIAGVNFVLPPVFKLIAPLEGYTRSRQIVFIL 430

Query: 375 IWCVVLKLASLGMFSVSLGQTILCIGRDKSS-CESYGYNVCDYQCWENSVGEELYKLSIF 433
           +  V L+LASL +   SL   I C G  ++  C++ GYN     CWE  +G+E+YKL +F
Sbjct: 431 LRTVFLRLASLVVLLFSLWNQITCGGDSEAEDCKTCGYNYKQLPCWETVLGQEMYKLLLF 490

Query: 434 NFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVTWMGLFYCP 493
           + L  +A A L+  PR+LL     G        +EF VP  VL ++  QTV W+G F+CP
Sbjct: 491 DLLTVLAVALLIQFPRKLLCGLCPGALGRLAGTQEFQVPDEVLGLIYAQTVVWVGSFFCP 550

Query: 494 LLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVLLLGLLLAAVPLGYVV 553
           LLPLLN+V   L FY+KK TL      ++R FRAS++ FFF LVLLLGL +++VPL Y +
Sbjct: 551 LLPLLNTVKFLLLFYLKKLTLFSTCSPAARTFRASAANFFFPLVLLLGLAISSVPLLYSI 610

Query: 554 SSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFSFPLLIMLSLVLTV 613
             I  S  CG F   S+ W  +PE ++  LP   Q  L +LG+ AF+ PLL++ S+++  
Sbjct: 611 FLIPPSKLCGPFRGQSSIWAQIPESIS-SLPETTQNFLFFLGTQAFAVPLLLISSILMAY 669

Query: 614 CVSQTQANARAIHRLRKQLVWQVQEK 639
            V+   +  R I  L++Q   + Q K
Sbjct: 670 TVALANSYGRLISELKRQRQTEAQNK 695


>gi|157426860 transmembrane channel-like 5 isoform a [Homo sapiens]
          Length = 1006

 Score =  197 bits (501), Expect = 3e-50
 Identities = 153/591 (25%), Positives = 274/591 (46%), Gaps = 64/591 (10%)

Query: 75  RRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLP 134
           RR + +   +   + LW+  L  IGG FGT + SYF FLR+LL  N+ S +L  SF+++P
Sbjct: 415 RRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIP 474

Query: 135 LVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAYRVGP- 193
              +   +       TLQ  G        L F   + +      F +T ++YG Y     
Sbjct: 475 QFTVAKKN-------TLQFTG--------LEFFTGVGY------FRDTVMYYGFYTNSTI 513

Query: 194 ---ESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSW 250
               S + Y+++LAY+ +  ACL  CF   L  M K      +    Y   ++  +F  W
Sbjct: 514 QHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFC-W 572

Query: 251 DFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLV 310
           DF +  ++A  +K+  +S E +  L E R  Q   + T  Q   R  +Y+   V++  + 
Sbjct: 573 DFTVTHEKAVKLKQKNLSTEIRENLSELR--QENSKLTFNQLLTRFSAYMVAWVVSTGVA 630

Query: 311 VGAISAIFWATKYSQD----NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYP- 365
           +   +A+++  +Y+ +    +      LLL    P V++ +N   P +++    +E Y  
Sbjct: 631 IACCAAVYYLAEYNLEFLKTHSNPGAVLLL----PFVVSCINLAVPCIYSMFRLVERYEM 686

Query: 366 PNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWENSVGE 425
           P  EV + LI  + LK++ +G+       T+   G +               CWE  +G+
Sbjct: 687 PRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE---------------CWETLIGQ 731

Query: 426 ELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVT 485
           ++Y+L + +F+ ++  +FL    RR++      +    L  +EF + +NVL+++  QT+ 
Sbjct: 732 DIYRLLLMDFVFSLVNSFLGEFLRRII----GMQLITSLGLQEFDIARNVLELIYAQTLV 787

Query: 486 WMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASS-STFFFQLVLLLGLLL 544
           W+G+F+CPLLP +  + LF+ FY K  +L+ N +  S+ +RAS   TFF  L+       
Sbjct: 788 WIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTG 847

Query: 545 AAVPLGYVVSSIHSSWDCG------LFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHA 598
               L   +  +  S DCG      LF +    W +       G   +     + +GS  
Sbjct: 848 VLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSW-IDTLSTRPGYLWVVWIYRNLIGSVH 906

Query: 599 FSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRL 649
           F F L +++ ++  +    T+     I  L +Q++ + ++K  L+E L +L
Sbjct: 907 FFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKL 957


>gi|31377679 transmembrane channel-like 5 isoform c [Homo sapiens]
          Length = 760

 Score =  197 bits (501), Expect = 3e-50
 Identities = 153/591 (25%), Positives = 274/591 (46%), Gaps = 64/591 (10%)

Query: 75  RRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLP 134
           RR + +   +   + LW+  L  IGG FGT + SYF FLR+LL  N+ S +L  SF+++P
Sbjct: 169 RRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIP 228

Query: 135 LVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAYRVGP- 193
              +   +       TLQ  G        L F   + +      F +T ++YG Y     
Sbjct: 229 QFTVAKKN-------TLQFTG--------LEFFTGVGY------FRDTVMYYGFYTNSTI 267

Query: 194 ---ESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSW 250
               S + Y+++LAY+ +  ACL  CF   L  M K      +    Y   ++  +F  W
Sbjct: 268 QHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFC-W 326

Query: 251 DFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLV 310
           DF +  ++A  +K+  +S E +  L E R  Q   + T  Q   R  +Y+   V++  + 
Sbjct: 327 DFTVTHEKAVKLKQKNLSTEIRENLSELR--QENSKLTFNQLLTRFSAYMVAWVVSTGVA 384

Query: 311 VGAISAIFWATKYSQD----NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYP- 365
           +   +A+++  +Y+ +    +      LLL    P V++ +N   P +++    +E Y  
Sbjct: 385 IACCAAVYYLAEYNLEFLKTHSNPGAVLLL----PFVVSCINLAVPCIYSMFRLVERYEM 440

Query: 366 PNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWENSVGE 425
           P  EV + LI  + LK++ +G+       T+   G +               CWE  +G+
Sbjct: 441 PRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE---------------CWETLIGQ 485

Query: 426 ELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVT 485
           ++Y+L + +F+ ++  +FL    RR++      +    L  +EF + +NVL+++  QT+ 
Sbjct: 486 DIYRLLLMDFVFSLVNSFLGEFLRRII----GMQLITSLGLQEFDIARNVLELIYAQTLV 541

Query: 486 WMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASS-STFFFQLVLLLGLLL 544
           W+G+F+CPLLP +  + LF+ FY K  +L+ N +  S+ +RAS   TFF  L+       
Sbjct: 542 WIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLLFFPSFTG 601

Query: 545 AAVPLGYVVSSIHSSWDCG------LFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHA 598
               L   +  +  S DCG      LF +    W +       G   +     + +GS  
Sbjct: 602 VLCTLAITIWRLKPSADCGPFRGLPLFIHSIYSW-IDTLSTRPGYLWVVWIYRNLIGSVH 660

Query: 599 FSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQEKWHLVEDLSRL 649
           F F L +++ ++  +    T+     I  L +Q++ + ++K  L+E L +L
Sbjct: 661 FFFILTLIVLIITYLYWQITEGRKIMIRLLHEQIINEGKDKMFLIEKLIKL 711


>gi|157426862 transmembrane channel-like 5 isoform b [Homo sapiens]
          Length = 948

 Score =  187 bits (475), Expect = 3e-47
 Identities = 129/473 (27%), Positives = 228/473 (48%), Gaps = 56/473 (11%)

Query: 75  RRLREAAQRLARGLGLWEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLP 134
           RR + +   +   + LW+  L  IGG FGT + SYF FLR+LL  N+ S +L  SF+++P
Sbjct: 415 RRSKNSLSEILNSISLWQKTLKIIGGKFGTSVLSYFNFLRWLLKFNIFSFILNFSFIIIP 474

Query: 135 LVWLRPPDPGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAYRVGP- 193
              +   +       TLQ  G        L F   + +      F +T ++YG Y     
Sbjct: 475 QFTVAKKN-------TLQFTG--------LEFFTGVGY------FRDTVMYYGFYTNSTI 513

Query: 194 ---ESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSW 250
               S + Y+++LAY+ +  ACL  CF   L  M K      +    Y   ++  +F  W
Sbjct: 514 QHGNSGASYNMQLAYIFTIGACLTTCFFSLLFSMAKYFRNNFINPHIYSGGITKLIFC-W 572

Query: 251 DFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRVNVLNGLLV 310
           DF +  ++A  +K+  +S E +  L E R  Q   + T  Q   R  +Y+   V++  + 
Sbjct: 573 DFTVTHEKAVKLKQKNLSTEIRENLSELR--QENSKLTFNQLLTRFSAYMVAWVVSTGVA 630

Query: 311 VGAISAIFWATKYSQD----NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYP- 365
           +   +A+++  +Y+ +    +      LLL    P V++ +N   P +++    +E Y  
Sbjct: 631 IACCAAVYYLAEYNLEFLKTHSNPGAVLLL----PFVVSCINLAVPCIYSMFRLVERYEM 686

Query: 366 PNTEVNLTLIWCVVLKLASLGMFSVSLGQTILCIGRDKSSCESYGYNVCDYQCWENSVGE 425
           P  EV + LI  + LK++ +G+       T+   G +               CWE  +G+
Sbjct: 687 PRHEVYVLLIRNIFLKISIIGILCYYWLNTVALSGEE---------------CWETLIGQ 731

Query: 426 ELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLEREEFLVPKNVLDIVAGQTVT 485
           ++Y+L + +F+ ++  +FL    RR++      +    L  +EF + +NVL+++  QT+ 
Sbjct: 732 DIYRLLLMDFVFSLVNSFLGEFLRRII----GMQLITSLGLQEFDIARNVLELIYAQTLV 787

Query: 486 WMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQLVL 538
           W+G+F+CPLLP +  + LF+ FY K  +L+ N +  S+ +RAS    FF  +L
Sbjct: 788 WIGIFFCPLLPFIQMIMLFIMFYSKNISLMMNFQPPSKAWRASQMMTFFIFLL 840


>gi|187608784 transmembrane channel-like 6 [Homo sapiens]
          Length = 805

 Score =  171 bits (434), Expect = 2e-42
 Identities = 190/670 (28%), Positives = 293/670 (43%), Gaps = 122/670 (18%)

Query: 36  VRGLPYAMMDKRLIWQLREPAGVQTLRWQRWQRRRQTVE--RRLREAAQRLARGLGL--- 90
           +RG+P ++ +KR    LRE +     +W+             RLR A       LGL   
Sbjct: 165 LRGMPLSLAEKR---SLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALL 221

Query: 91  --------WEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPD 142
                   W  AL  IGG FG+ + SYF FL+ LL  N L LLL  +F++ P V   P  
Sbjct: 222 SALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFPPAL 281

Query: 143 PGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRA-FTNTYLFYGAY------------ 189
           PGP       C G                 +LTG   FT+T ++YG Y            
Sbjct: 282 PGPAP----VCTGLE---------------LLTGAGCFTHTVMYYGHYSNATLNQPCGSP 322

Query: 190 --------RVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAP 241
                   RVG      Y++ LAYL S +       C TL   V  +      G+ Y+  
Sbjct: 323 LDGSQCTPRVG---GLPYNMPLAYL-STVGVSFFITCITL---VYSMAHS--FGESYRVG 373

Query: 242 LSA-----KVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRL 296
            ++      VF SWD+ +  + A+ +++  I    K  L E       Q +   ++ C  
Sbjct: 374 STSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAE------WQLRHSPRSVCGR 427

Query: 297 LSYLRVNVLNGLLVVG-----AISAIFWATKYSQDNK---EESLFLLLQYLPPGVIALVN 348
           L    V  L  LL +G     A++   ++    Q  +   +E++ L+L    P V+ L+N
Sbjct: 428 LRQAAVLGLVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVL----PLVVGLLN 483

Query: 349 FLGPLLFTFLVQLENYP-PNTEVNLTLIWCVVLKLASLGMFSVS-LGQTILCIGRDKSSC 406
              P L   L  LE +  P  EV + +   ++LKLA LG      LG+ +          
Sbjct: 484 LGAPYLCRVLAALEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRV---------- 533

Query: 407 ESYGYNVCDYQCWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLER 466
                 V   QCWE+ VG+ELY+  + +F+L +       L  R++ ++   R      +
Sbjct: 534 -----GVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIISEKKLKR----RRK 584

Query: 467 EEFLVPKNVLDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFR 526
            EF + +NVL+++ GQT+TW+G+ + PLLP +  + L L FY+KK +LL N +A  RP+ 
Sbjct: 585 PEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPWL 644

Query: 527 AS-SSTFFFQLVLLLGLLLAAVPLGYVVSSIHSSWDCGLF----TNYSAPWQVVPELVAL 581
           AS  ST F  L+     L AAV L Y V  +  S  CG F    T Y A    V  L A 
Sbjct: 645 ASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEAA 704

Query: 582 G-----LPPIGQRALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQV 636
           G     LP + +   + + +  F F +  +L  V+ + +   +   + I  L++Q+  + 
Sbjct: 705 GPRVSWLPWVHR---YLMENTFFVFLVSALLLAVIYLNIQVVRGQRKVICLLKEQISNEG 761

Query: 637 QEKWHLVEDL 646
           ++K  L+  L
Sbjct: 762 EDKIFLINKL 771


>gi|187608791 transmembrane channel-like 6 [Homo sapiens]
          Length = 805

 Score =  171 bits (434), Expect = 2e-42
 Identities = 190/670 (28%), Positives = 293/670 (43%), Gaps = 122/670 (18%)

Query: 36  VRGLPYAMMDKRLIWQLREPAGVQTLRWQRWQRRRQTVE--RRLREAAQRLARGLGL--- 90
           +RG+P ++ +KR    LRE +     +W+             RLR A       LGL   
Sbjct: 165 LRGMPLSLAEKR---SLREKSRTPRGKWRGQPGSGGVCSCCGRLRYACVLALHSLGLALL 221

Query: 91  --------WEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPD 142
                   W  AL  IGG FG+ + SYF FL+ LL  N L LLL  +F++ P V   P  
Sbjct: 222 SALQALMPWRYALKRIGGQFGSSVLSYFLFLKTLLAFNALLLLLLVAFIMGPQVAFPPAL 281

Query: 143 PGPTLNLTLQCPGSRQSPPGVLRFHNQLWHVLTGRA-FTNTYLFYGAY------------ 189
           PGP       C G                 +LTG   FT+T ++YG Y            
Sbjct: 282 PGPAP----VCTGLE---------------LLTGAGCFTHTVMYYGHYSNATLNQPCGSP 322

Query: 190 --------RVGPESSSVYSIRLAYLLSPLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAP 241
                   RVG      Y++ LAYL S +       C TL   V  +      G+ Y+  
Sbjct: 323 LDGSQCTPRVG---GLPYNMPLAYL-STVGVSFFITCITL---VYSMAHS--FGESYRVG 373

Query: 242 LSA-----KVFSSWDFCIRVQEAATIKKHEISNEFKVELEEGRRFQLMQQQTRAQTACRL 296
            ++      VF SWD+ +  + A+ +++  I    K  L E       Q +   ++ C  
Sbjct: 374 STSGIHAITVFCSWDYKVTQKRASRLQQDNIRTRLKELLAE------WQLRHSPRSVCGR 427

Query: 297 LSYLRVNVLNGLLVVG-----AISAIFWATKYSQDNK---EESLFLLLQYLPPGVIALVN 348
           L    V  L  LL +G     A++   ++    Q  +   +E++ L+L    P V+ L+N
Sbjct: 428 LRQAAVLGLVWLLCLGTALGCAVAVHVFSEFMIQSPEAAGQEAVLLVL----PLVVGLLN 483

Query: 349 FLGPLLFTFLVQLENYP-PNTEVNLTLIWCVVLKLASLGMFSVS-LGQTILCIGRDKSSC 406
              P L   L  LE +  P  EV + +   ++LKLA LG      LG+ +          
Sbjct: 484 LGAPYLCRVLAALEPHDSPVLEVYVAICRNLILKLAILGTLCYHWLGRRV---------- 533

Query: 407 ESYGYNVCDYQCWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAWLER 466
                 V   QCWE+ VG+ELY+  + +F+L +       L  R++ ++   R      +
Sbjct: 534 -----GVLQGQCWEDFVGQELYRFLVMDFVLMLLDTLFGELVWRIISEKKLKR----RRK 584

Query: 467 EEFLVPKNVLDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFR 526
            EF + +NVL+++ GQT+TW+G+ + PLLP +  + L L FY+KK +LL N +A  RP+ 
Sbjct: 585 PEFDIARNVLELIYGQTLTWLGVLFSPLLPAVQIIKLLLVFYVKKTSLLANCQAPRRPWL 644

Query: 527 AS-SSTFFFQLVLLLGLLLAAVPLGYVVSSIHSSWDCGLF----TNYSAPWQVVPELVAL 581
           AS  ST F  L+     L AAV L Y V  +  S  CG F    T Y A    V  L A 
Sbjct: 645 ASHMSTVFLTLLCFPAFLGAAVFLCYAVWQVKPSSTCGPFRTLDTMYEAGRVWVRHLEAA 704

Query: 582 G-----LPPIGQRALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQV 636
           G     LP + +   + + +  F F +  +L  V+ + +   +   + I  L++Q+  + 
Sbjct: 705 GPRVSWLPWVHR---YLMENTFFVFLVSALLLAVIYLNIQVVRGQRKVICLLKEQISNEG 761

Query: 637 QEKWHLVEDL 646
           ++K  L+  L
Sbjct: 762 EDKIFLINKL 771


>gi|94536852 transmembrane cochlear-expressed protein 2 [Homo
           sapiens]
          Length = 906

 Score =  154 bits (388), Expect = 4e-37
 Identities = 147/587 (25%), Positives = 256/587 (43%), Gaps = 53/587 (9%)

Query: 91  WEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPGPTLNLT 150
           WE  + +I   FG+ + SYF FLR++  +NL+   L    V++P V +  P         
Sbjct: 234 WEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTV 293

Query: 151 LQCPGSRQSPPGVL-RFHNQLWHVLTGRAFTNTYLFYGAYRVGPESSSV-YSIRLAYLLS 208
            +    +     VL  F   + +         + LFYG Y        + Y + +AY + 
Sbjct: 294 PRAEEEKAMDFSVLWDFEGYIKY---------SALFYGYYNNQRTIGWLRYRLPMAYFMV 344

Query: 209 PLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKHEIS 268
            ++         +R M       T  G+      S K+F+SWD+ I   E A  K   I+
Sbjct: 345 GVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASIT 404

Query: 269 NEFKVELEEGRRFQLMQQQTRAQTACRLLSYLRV--NVLNGLLVVGAISAIFWATKYSQD 326
             FK  + +       +Q++  +    L  +LRV  N L    + G+   I++  K SQ 
Sbjct: 405 TSFKESIVD-------EQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQ 457

Query: 327 -NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLTLIWCVVLKLASL 385
            +K +++    +     V++L+    P LF  +  LENY P T +   L     L L +L
Sbjct: 458 FSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNL 517

Query: 386 GMFSVSLGQTI-LCIGRDKSSCESYGYNVCDY-----------------------QCWEN 421
             F ++L   + L +  +++      + + +Y                        CWE 
Sbjct: 518 YTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWET 577

Query: 422 SVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAW-LER-----EEFLVPKNV 475
           +VG E  +L++ + L+T     L    R   V RF    W W LE       EF +  NV
Sbjct: 578 AVGIEFMRLTVSDMLVTYITILLGDFLRACFV-RFMNYCWCWDLEAGFPSYAEFDISGNV 636

Query: 476 LDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSSTFFFQ 535
           L ++  Q + WMG FY P L  +N + L  + Y + + ++ ++    R F+AS S  F+ 
Sbjct: 637 LGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYM 696

Query: 536 LVLLLGLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRALHYLG 595
            +LLL L L+ +P+ Y + S+  S+DCG F+  +  + V+ E +    P    +   +L 
Sbjct: 697 GLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLA 756

Query: 596 SHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQL-VWQVQEKWH 641
           +     P ++++ L +    S +++ +RA  +LRK++ V +  EK H
Sbjct: 757 NPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSH 803


>gi|21071070 transmembrane channel-like 1 [Homo sapiens]
          Length = 760

 Score =  152 bits (383), Expect = 1e-36
 Identities = 152/589 (25%), Positives = 256/589 (43%), Gaps = 59/589 (10%)

Query: 91  WEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLP-LVWLRPPDPGPTLNL 149
           WE  +  I   FG+ + SYF FLR++  +N++  +LT S ++LP  +W  P    P   +
Sbjct: 170 WENKIKAIESQFGSSVASYFLFLRWMYGVNMVLFILTFSLIMLPEYLWGLPYGSLPRKTV 229

Query: 150 TLQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAYRVGPESSSV-YSIRLAYLLS 208
             +   +  +  GVL   N L           + LFYG Y        + + + L+Y L 
Sbjct: 230 P-RAEEASAANFGVLYDFNGLAQY--------SVLFYGYYDNKRTIGWMNFRLPLSYFLV 280

Query: 209 PLACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKHEIS 268
            + C+   F   L+ M K +      G       S KVF+SWD+ I   E A  K + I+
Sbjct: 281 GIMCIGYSFLVVLKAMTKNIGDDGG-GDDNTFNFSWKVFTSWDYLIGNPETADNKFNSIT 339

Query: 269 NEFKVELEEGRRFQLMQQQTRAQTACRLLSYLR--VNVLNGLLVVGAISAIFWATKYSQD 326
             FK  + E +  Q+ +          L+ +LR   N    L + G+   IFWA K SQ+
Sbjct: 340 MNFKEAITEEKAAQVEEN-------VHLIRFLRFLANFFVFLTLGGSGYLIFWAVKRSQE 392

Query: 327 NKEESLFLLLQYLPPGVIALVNFLG---PLLFTFLVQLENYPPNTEVNLTLIWCVVLKLA 383
             ++    L  +    +  +++ LG   P LF    +LE+Y P   +   L     L L 
Sbjct: 393 FAQQDPDTLGWWEKNEMNMVMSLLGMFCPTLFDLFAELEDYHPLIALKWLLGRIFALLLG 452

Query: 384 SLGMFSVSLGQ----------------TILCIGRDKSSCESYGYN------------VCD 415
           +L +F ++L                  T+      K+   S+  N            V  
Sbjct: 453 NLYVFILALMDEINNKIEEEKLVKANITLWEANMIKAYNASFSENSTGPPFFVHPADVPR 512

Query: 416 YQCWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAW-LER-----EEF 469
             CWE  VG+E  +L++ + L T     +    R   V RF    W W LE       EF
Sbjct: 513 GPCWETMVGQEFVRLTVSDVLTTYVTILIGDFLRACFV-RFCNYCWCWDLEYGYPSYTEF 571

Query: 470 LVPKNVLDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASS 529
            +  NVL ++  Q + WMG F+ P LP +N + L  + Y + + ++  +   +R F+AS 
Sbjct: 572 DISGNVLALIFNQGMIWMGSFFAPSLPGINILRLHTSMYFQCWAVMCCNVPEARVFKASR 631

Query: 530 STFFFQLVLLLGLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQR 589
           S  F+  +LLL L L+ +P+ Y++ S+  S+DCG F+  +  ++V+ E +    P    +
Sbjct: 632 SNNFYLGMLLLILFLSTMPVLYMIVSLPPSFDCGPFSGKNRMFEVIGETLEHDFPSWMAK 691

Query: 590 ALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQLVWQVQE 638
            L  L +      +++++ L +    +  +    A   L+K++  Q  E
Sbjct: 692 ILRQLSNPGLVIAVILVMVLAIYYLNATAKGQKAANLDLKKKMKMQALE 740


>gi|122937502 transmembrane channel-like 3 [Homo sapiens]
          Length = 1100

 Score =  108 bits (271), Expect = 1e-23
 Identities = 66/222 (29%), Positives = 109/222 (49%), Gaps = 7/222 (3%)

Query: 417 QCWENSVGEELYKLSIFNFLLTVAFAFLVTLPRRLLVDRFSGRFWAW------LEREEFL 470
           QCWE  VG+E+ KLSI + L TVA   L+   R L V R+   +W W       E  EF 
Sbjct: 498 QCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFV-RYLSDYWCWDLESKFPEYGEFK 556

Query: 471 VPKNVLDIVAGQTVTWMGLFYCPLLPLLNSVFLFLTFYIKKYTLLKNSRASSRPFRASSS 530
           + +NVL +V  Q + WMG F+ P LP  N + L    Y++ + +L  +    + FRAS S
Sbjct: 557 IAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRS 616

Query: 531 TFFFQLVLLLGLLLAAVPLGYVVSSIHSSWDCGLFTNYSAPWQVVPELVALGLPPIGQRA 590
             F+  +LL  L L  +P  + +     S +CG F+     + +V E +    P      
Sbjct: 617 NNFYLAMLLFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSV 676

Query: 591 LHYLGSHAFSFPLLIMLSLVLTVCVSQTQANARAIHRLRKQL 632
           + ++ S     P +++L +++    S  ++   + H+L+ Q+
Sbjct: 677 VGHISSPVVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQI 718



 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 84/306 (27%), Positives = 140/306 (45%), Gaps = 18/306 (5%)

Query: 91  WEGALYEIGGLFGTGIRSYFTFLRFLLLLNLLSLLLTASFVLLPLVWLRPPDPGPTLNLT 150
           WE  + +I   FG+G+ SYF FLR+L  +N++  ++T +F+++P +    P  G T   T
Sbjct: 123 WEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPF-GSTARKT 181

Query: 151 LQCPGSRQSPPGVLRFHNQLWHVLTGRAFTNTYLFYGAY-RVGPESSSVYSIRLAYLLSP 209
           +  P  + S    L   + +W +  G     + LFYG Y R      + Y + LAY L  
Sbjct: 182 I--PKEQVSSAQDL---DTVWSL--GGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVG 234

Query: 210 LACLLLCFCGTLRRMVKGLPQKTLLGQGYQAPLSAKVFSSWDFCIRVQEAATIKKHEISN 269
           +A     F   L++M K                  +VF +WD+ I   EAA  K   I N
Sbjct: 235 MAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAIVN 294

Query: 270 EFKVELEEGRRFQLMQQQTRAQTAC-RLLSYLRVNVLNGLLVVGAISAIFWATKYSQ--D 326
             +  + E +  +  + +  A T C R+++    N+L  L + G+I  I++    SQ  +
Sbjct: 295 SIREAILEEQ--EKKKSKNLAVTICLRIIA----NILVLLSLAGSIYLIYFVVDRSQKLE 348

Query: 327 NKEESLFLLLQYLPPGVIALVNFLGPLLFTFLVQLENYPPNTEVNLTLIWCVVLKLASLG 386
             ++ L L  +     V++LV  + P  F  +  LE Y P T +   L   +VL L +L 
Sbjct: 349 QSKKELTLWEKNEVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLY 408

Query: 387 MFSVSL 392
              ++L
Sbjct: 409 SLIIAL 414


>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
          Length = 1497

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 26/66 (39%), Positives = 30/66 (45%), Gaps = 6/66 (9%)

Query: 653 PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSP----CPGQ 708
           PGP  +PGP  PA      +      P PG PG + P PGPS+    G R P     PG 
Sbjct: 832 PGPPGAPGPAGPAGLPGHQEVLNLQGP-PGPPGPRGP-PGPSIPGPPGPRGPPGEGLPGP 889

Query: 709 HGAPAS 714
            G P S
Sbjct: 890 PGPPGS 895



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 22/71 (30%), Positives = 25/71 (35%), Gaps = 12/71 (16%)

Query: 653 PGPSDSPGPKYPASQASRP----------QSFCPGCPCPGSP-GHQAPRPGPSVVDAAGL 701
           PGP    G K P      P          +    G   P  P GHQ PR    +    G+
Sbjct: 706 PGPKGDQGEKGPRGLTGEPGMRGLPGAVGEPGAKGAMGPAGPDGHQGPRGEQGLTGMPGI 765

Query: 702 RSPCPGQHGAP 712
           R P PG  G P
Sbjct: 766 RGP-PGPSGDP 775


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 39.3 bits (90), Expect = 0.013
 Identities = 23/65 (35%), Positives = 28/65 (43%), Gaps = 2/65 (3%)

Query: 651 PEPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHG 710
           P P P   P P   A+ A  P++       P SPG    +PGP    AA L +P P    
Sbjct: 129 PTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPG--PAQPGPRAQRAAPLAAPPPAPAA 186

Query: 711 APASA 715
            PA A
Sbjct: 187 PPAVA 191



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 14/36 (38%), Positives = 16/36 (44%)

Query: 658 SPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGP 693
           SPGP  P  +A R        P P +P   AP  GP
Sbjct: 161 SPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGP 196


>gi|56606142 complement component 1, q subcomponent-like 4 [Homo
           sapiens]
          Length = 238

 Score = 38.9 bits (89), Expect = 0.017
 Identities = 25/56 (44%), Positives = 28/56 (50%), Gaps = 5/56 (8%)

Query: 654 GPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPG--PSVVDAAGLRSPCPG 707
           GP   PGP+ P  +  RP    PG P PG PG  AP  G  P +   AGLR P  G
Sbjct: 70  GPPGPPGPRGPPGEPGRPGP--PGPPGPG-PGGVAPAAGYVPRIAFYAGLRRPHEG 122


>gi|134244285 Notch homolog 3 [Homo sapiens]
          Length = 2321

 Score = 38.1 bits (87), Expect = 0.029
 Identities = 29/74 (39%), Positives = 32/74 (43%), Gaps = 9/74 (12%)

Query: 650  LPEPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSV-VDAAGLRSPCPGQ 708
            LP P P   PGP +    A  PQ   PG P   SP     RP P + V   G   P  G 
Sbjct: 2175 LPPPAP---PGPSFLLPLAPGPQLLNPGTPV--SPQE---RPPPYLAVPGHGEEYPAAGA 2226

Query: 709  HGAPASARRFRFPS 722
            H +P  AR  R PS
Sbjct: 2227 HSSPPKARFLRVPS 2240



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 11/80 (13%)

Query: 637  QEKWHLVEDLSRLLPEP-GPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRP---- 691
            QE+ H  +D+ RLL +P GP   PGP         P +F PG     S   ++ RP    
Sbjct: 2013 QERLH--QDIVRLLDQPSGPRSPPGPHGLGPLLCPPGAFLPGLKAAQSGSKKSRRPPGKA 2070

Query: 692  --GPSVVDAAG--LRSPCPG 707
              GP      G  L   CPG
Sbjct: 2071 GLGPQGPRGRGKKLTLACPG 2090


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 37.7 bits (86), Expect = 0.038
 Identities = 23/63 (36%), Positives = 27/63 (42%), Gaps = 8/63 (12%)

Query: 653 PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAP 712
           PGP+  PGP  P   +  P S       PGSPG+Q P   P     +G   P PG  G  
Sbjct: 173 PGPAGPPGPPGPPGTSGHPGS-------PGSPGYQGPPGEPGQAGPSGPPGP-PGAIGPS 224

Query: 713 ASA 715
             A
Sbjct: 225 GPA 227



 Score = 37.7 bits (86), Expect = 0.038
 Identities = 32/81 (39%), Positives = 34/81 (41%), Gaps = 23/81 (28%)

Query: 653 PGPSDSPG---PKYPASQASRPQSFCPGCPCP----------GSPGHQAP--RPGP---- 693
           PGPS SPG   P  PA     P S  PG   P          GSPG Q P   PGP    
Sbjct: 893 PGPSGSPGKDGPPGPAGNTGAPGS--PGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIA 950

Query: 694 SVVDAAGLRSP--CPGQHGAP 712
            +  A GL  P   PG  G+P
Sbjct: 951 GITGARGLAGPPGMPGPRGSP 971



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 27/76 (35%), Positives = 32/76 (42%), Gaps = 17/76 (22%)

Query: 652  EPGPSDSPGPK-------YPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGL--- 701
            EPG   +PG          P  +  R ++  PG P  G+PGH  P PGP  V  AG    
Sbjct: 1009 EPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAP--GAPGHPGP-PGP--VGPAGKSGD 1063

Query: 702  --RSPCPGQHGAPASA 715
               S   G  GAP  A
Sbjct: 1064 RGESGPAGPAGAPGPA 1079



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 20/61 (32%), Positives = 22/61 (36%), Gaps = 8/61 (13%)

Query: 654 GPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPA 713
           GP+  PG K PA +         G P P  P   A  PG   V         PG  G P 
Sbjct: 495 GPNGIPGEKGPAGER--------GAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPG 546

Query: 714 S 714
           S
Sbjct: 547 S 547



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 8/62 (12%)

Query: 653  PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAP 712
            PGP  SPGP+    ++ +P +        G  G + P PGP  +      +  PG+ G P
Sbjct: 965  PGPRGSPGPQGVKGESGKPGA-------NGLSGERGP-PGPQGLPGLAGTAGEPGRDGNP 1016

Query: 713  AS 714
             S
Sbjct: 1017 GS 1018


>gi|4502961 alpha 1 type VII collagen precursor [Homo sapiens]
          Length = 2944

 Score = 37.4 bits (85), Expect = 0.050
 Identities = 25/72 (34%), Positives = 29/72 (40%), Gaps = 9/72 (12%)

Query: 653  PGPSDSPGPKYPASQASRPQSFCPGCPC-PGSPGHQAPRPGPSVVDAAGLRS-PCP---- 706
            PGP    GP     +    +   PG P  PGSPG Q PR  P  +   G R  P P    
Sbjct: 1432 PGPQGPVGPPGKKGEKGDSEDGAPGLPGQPGSPGEQGPRGPPGAIGPKGDRGFPGPLGEA 1491

Query: 707  ---GQHGAPASA 715
               G+ G P  A
Sbjct: 1492 GEKGERGPPGPA 1503



 Score = 33.5 bits (75), Expect = 0.71
 Identities = 22/64 (34%), Positives = 26/64 (40%), Gaps = 2/64 (3%)

Query: 652  EPGPSDSPGPKYP-ASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHG 710
            +PGPS  PGP+ P      R     PG    G  G +  R GP      G+    PG  G
Sbjct: 1369 DPGPSGPPGPRGPLGDPGPRGPPGLPGTAMKGDKGDRGER-GPPGPGEGGIAPGEPGLPG 1427

Query: 711  APAS 714
             P S
Sbjct: 1428 LPGS 1431



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 28/75 (37%), Positives = 35/75 (46%), Gaps = 8/75 (10%)

Query: 653  PGPSDSPGPK-YPASQASRPQSFCPGCP-CPGSPGHQAPRPGPSVVDAAGLR-SP-CPGQ 708
            PG + +PGP+  P S  ++ +   PG    PGSPG       P    A GL+ SP  PG 
Sbjct: 1277 PGRTGAPGPQGPPGSATAKGERGFPGADGRPGSPGRAG---NPGTPGAPGLKGSPGLPGP 1333

Query: 709  HGAPASARRFRFPSG 723
             G P   R  R P G
Sbjct: 1334 RGDPGE-RGPRGPKG 1347



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 25/72 (34%), Positives = 28/72 (38%), Gaps = 9/72 (12%)

Query: 652  EPGPSDSPGPKYP---ASQASRPQSFCP----GCP-CPGSPGHQAPRPGPSVVDAAGLRS 703
            +PGP   PG + P     +A  P    P    G P  PG PG   PR     V   G   
Sbjct: 1584 DPGPKGDPGDRGPIGLTGRAGPPGDSGPPGEKGDPGRPGPPGPVGPRGRDGEVGEKGDEG 1643

Query: 704  PCPGQHGAPASA 715
            P PG  G P  A
Sbjct: 1644 P-PGDPGLPGKA 1654


>gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 36.6 bits (83), Expect = 0.084
 Identities = 24/64 (37%), Positives = 28/64 (43%), Gaps = 2/64 (3%)

Query: 651 PEPGPSDSPGPKYPASQASRPQSFCP-GCPCPGSPGHQAPRPGPSVVDAAGLRS-PCPGQ 708
           PEPG  D PG    A   +  +   P G P P SPG   P PG +    A   + P PG 
Sbjct: 19  PEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGL 78

Query: 709 HGAP 712
            G P
Sbjct: 79  EGGP 82


>gi|116256356 alpha 4 type IV collagen precursor [Homo sapiens]
          Length = 1690

 Score = 36.6 bits (83), Expect = 0.084
 Identities = 28/71 (39%), Positives = 28/71 (39%), Gaps = 10/71 (14%)

Query: 653  PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAP 712
            PGP  S GP  PA    R        P PG PG Q P PGP      G R   PG  G P
Sbjct: 1232 PGPPGSSGPPGPAGATGRAPK---DIPDPGPPGDQGP-PGPD-----GPRG-APGPPGLP 1281

Query: 713  ASARRFRFPSG 723
             S    R   G
Sbjct: 1282 GSVDLLRGEPG 1292



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 24/69 (34%), Positives = 24/69 (34%), Gaps = 23/69 (33%)

Query: 653  PGPSDSPGPKYPASQASRPQSFCPGCPC-------PGSPGHQAPRPGPSVVDAAGLRSP- 704
            PGP   PG               PGCP         G PG Q PR  P      G   P 
Sbjct: 1084 PGPKGEPGS--------------PGCPGHFGASGEQGLPGIQGPRGSPGRPGPPGSSGPP 1129

Query: 705  -CPGQHGAP 712
             CPG HG P
Sbjct: 1130 GCPGDHGMP 1138



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 24/65 (36%), Positives = 27/65 (41%), Gaps = 18/65 (27%)

Query: 652 EPGPSDSPGPK-YPASQASRPQSFCPGC----PCPGSPGHQAPRPGPSVVDAAGLRSPCP 706
           EPGP   PGP   P  Q S+     PG       PG PG + P PG             P
Sbjct: 495 EPGPMGPPGPPGLPGRQGSKGDLGLPGWLGTKGDPGPPGAEGP-PG------------LP 541

Query: 707 GQHGA 711
           G+HGA
Sbjct: 542 GKHGA 546



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 22/71 (30%), Positives = 26/71 (36%), Gaps = 9/71 (12%)

Query: 653  PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAP 712
            PGP   PGP  P      P        C G  G + P   P      G   P PG+ G P
Sbjct: 1297 PGPPGPPGPPGPPGYKGFP-------GCDGKDGQKGPVGFPGPQGPHGFPGP-PGEKGLP 1348

Query: 713  ASARRFRFPSG 723
                R + P+G
Sbjct: 1349 GPPGR-KGPTG 1358


>gi|195972903 zinc finger protein 385A isoform a [Homo sapiens]
          Length = 386

 Score = 36.6 bits (83), Expect = 0.084
 Identities = 45/164 (27%), Positives = 64/164 (39%), Gaps = 32/164 (19%)

Query: 563 GLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANA 622
           GLF+NYS             + P+ +  L    SH F  PLL     V++  + Q + N+
Sbjct: 42  GLFSNYST------------MDPVQKAVL----SHTFGGPLLKTKRPVISCNICQIRFNS 85

Query: 623 RA---IHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPGPKYPASQ-------ASRPQ 672
           ++    H    +   +V+     +E       EPG  +   P  P S        A RP 
Sbjct: 86  QSQAEAHYKGNRHARRVKG----IEAAKTRGREPGVREPGDPAPPGSTPTNGDGVAPRPV 141

Query: 673 SFCPGC-PCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASA 715
           S   G  P PGSP  Q   P P  +   G +    G+ G PA A
Sbjct: 142 SMENGLGPAPGSPEKQPGSPSPPSIPETG-QGVTKGEGGTPAPA 184


>gi|24308079 zinc finger protein 385A isoform c [Homo sapiens]
          Length = 366

 Score = 36.6 bits (83), Expect = 0.084
 Identities = 45/164 (27%), Positives = 64/164 (39%), Gaps = 32/164 (19%)

Query: 563 GLFTNYSAPWQVVPELVALGLPPIGQRALHYLGSHAFSFPLLIMLSLVLTVCVSQTQANA 622
           GLF+NYS             + P+ +  L    SH F  PLL     V++  + Q + N+
Sbjct: 22  GLFSNYST------------MDPVQKAVL----SHTFGGPLLKTKRPVISCNICQIRFNS 65

Query: 623 RA---IHRLRKQLVWQVQEKWHLVEDLSRLLPEPGPSDSPGPKYPASQ-------ASRPQ 672
           ++    H    +   +V+     +E       EPG  +   P  P S        A RP 
Sbjct: 66  QSQAEAHYKGNRHARRVKG----IEAAKTRGREPGVREPGDPAPPGSTPTNGDGVAPRPV 121

Query: 673 SFCPGC-PCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHGAPASA 715
           S   G  P PGSP  Q   P P  +   G +    G+ G PA A
Sbjct: 122 SMENGLGPAPGSPEKQPGSPSPPSIPETG-QGVTKGEGGTPAPA 164


>gi|32964830 collagen, type VIII, alpha 2 [Homo sapiens]
          Length = 703

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 27/65 (41%), Positives = 29/65 (44%), Gaps = 9/65 (13%)

Query: 652 EPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPG-HQAPRP-GPSVVDAAGLRSP--CPG 707
           EPGP   PGP+ P      P  F PG P  G PG H  P P GP      G   P   PG
Sbjct: 78  EPGPPGKPGPRGPPG----PPGF-PGKPGMGKPGLHGQPGPAGPPGFSRMGKAGPPGLPG 132

Query: 708 QHGAP 712
           + G P
Sbjct: 133 KVGPP 137



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 29/83 (34%), Positives = 36/83 (43%), Gaps = 19/83 (22%)

Query: 653 PGPSDSPGPK---------YPASQASRPQSFCPGCPCP-GSPGHQAPRPGPSVVDAAGLR 702
           PGP   PGP           P +   + +S  PG P P G PG   P+ GP  VD  G+ 
Sbjct: 225 PGPPGLPGPAGLGKPGLDGLPGAPGDKGESGPPGVPGPRGEPGAVGPK-GPPGVDGVGV- 282

Query: 703 SPCPGQHGAPASARRFRFPSGAE 725
              PG  G P      + PSGA+
Sbjct: 283 ---PGAAGLPGP----QGPSGAK 298



 Score = 33.1 bits (74), Expect = 0.93
 Identities = 22/62 (35%), Positives = 27/62 (43%), Gaps = 2/62 (3%)

Query: 652 EPGPSDSPGPKYPASQASRPQSFCPGCPCP-GSPGHQAPRPGPSVVDAAGLRSPCPGQHG 710
           +PG    PGP  P   +   ++  PG P   G PG    R  P +    GLR P PG  G
Sbjct: 104 KPGLHGQPGPAGPPGFSRMGKAGPPGLPGKVGPPGQPGLRGEPGIRGDQGLRGP-PGPPG 162

Query: 711 AP 712
            P
Sbjct: 163 LP 164



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 3/62 (4%)

Query: 652 EPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSP-CPGQHG 710
           EPGP   PGP  P  +  +  +       PG+PG       P +   AGL  P   G  G
Sbjct: 189 EPGPQGEPGP--PGDRGLKGDNGVGQPGLPGAPGQGGAPGPPGLPGPAGLGKPGLDGLPG 246

Query: 711 AP 712
           AP
Sbjct: 247 AP 248



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 25/70 (35%), Positives = 28/70 (40%), Gaps = 13/70 (18%)

Query: 654 GPSDSPGPKYPASQASRPQSFC-----PGCPCP------GSPGHQAPRPGPSVVDAAGLR 702
           GPS  PG + PA     PQ        PG P P      G PG   P   P V  + G+ 
Sbjct: 460 GPSGIPGLQGPAGPIG-PQGLPGLKGEPGLPGPPGEGRAGEPGTAGPTGPPGVPGSPGIT 518

Query: 703 SPCPGQHGAP 712
            P PG  G P
Sbjct: 519 GP-PGPPGPP 527


>gi|55743096 collagen, type XIV, alpha 1 [Homo sapiens]
          Length = 1796

 Score = 36.2 bits (82), Expect = 0.11
 Identities = 25/67 (37%), Positives = 31/67 (46%), Gaps = 12/67 (17%)

Query: 654  GPSDSPGPKYPASQASRPQSFCPGCPCP-------GSPGHQAP--RPG---PSVVDAAGL 701
            GP   PGP  P+ ++       PG P P       G PG Q P  +PG   PS   A G+
Sbjct: 1710 GPRGPPGPAGPSGESRPGSPGPPGSPGPRGPPGHLGVPGPQGPSGQPGYCDPSSCSAYGV 1769

Query: 702  RSPCPGQ 708
            R+P P Q
Sbjct: 1770 RAPHPDQ 1776



 Score = 31.2 bits (69), Expect = 3.5
 Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 2/61 (3%)

Query: 653  PGPSDSPGPKYPASQASRPQSFCPGCPC-PGSPGHQAPRPGPSVVDAAGLRSPCPGQHGA 711
            PGP   PGP+ P+  + +     PG     G  G   P+  P  V + G R   PGQ G 
Sbjct: 1497 PGPQGPPGPQGPSGLSIQGMPGMPGEKGEKGDTGLPGPQGIPGGVGSPG-RDGSPGQRGL 1555

Query: 712  P 712
            P
Sbjct: 1556 P 1556


>gi|7662302 TBK1 binding protein 1 [Homo sapiens]
          Length = 615

 Score = 35.8 bits (81), Expect = 0.14
 Identities = 21/71 (29%), Positives = 26/71 (36%)

Query: 651 PEPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSPCPGQHG 710
           P P P     P  P  Q+  PQ   P  PCP     ++P            RSP P    
Sbjct: 348 PSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSPQQRRSPASPSCPSPVPQRRSPVPPSCQ 407

Query: 711 APASARRFRFP 721
           +P+  RR   P
Sbjct: 408 SPSPQRRSPVP 418


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 24/82 (29%), Positives = 32/82 (39%), Gaps = 12/82 (14%)

Query: 643 VEDLSRLLPEPGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLR 702
           +   S   P   P+DSP P+  +   +   S  P      S G  AP P P VV  A +R
Sbjct: 345 IASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPAPKPRVVTTASIR 404

Query: 703 ------------SPCPGQHGAP 712
                       SP PG + +P
Sbjct: 405 PSVYQPVPASTYSPSPGANYSP 426



 Score = 30.8 bits (68), Expect = 4.6
 Identities = 27/82 (32%), Positives = 31/82 (37%), Gaps = 16/82 (19%)

Query: 651 PEPGPSDSPGPKY-----PASQASRP---------QSFCPGCPCPGSPGHQAPRPGPSVV 696
           P P P+ +P P       PA  ASRP         Q F PG           PR GP+  
Sbjct: 463 PSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTSISKQTLPRGGPAYT 522

Query: 697 DAAGLRSPCPGQHGAPASARRF 718
             AG + P P   G    A RF
Sbjct: 523 -PAGPQVP-PLARGTVQRAERF 542


>gi|194294532 alpha 1 type XIII collagen isoform 20 [Homo sapiens]
          Length = 717

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/64 (32%), Positives = 25/64 (39%), Gaps = 9/64 (14%)

Query: 653 PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSP-----CPG 707
           PGP   PGP  P      P    P    PG PG   P+  P +    G +        PG
Sbjct: 272 PGPPGPPGPSGPLGHPGLPGPMGP----PGLPGPPGPKGDPGIQGYHGRKGERGMPGMPG 327

Query: 708 QHGA 711
           +HGA
Sbjct: 328 KHGA 331



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 5/46 (10%)

Query: 652 EPGPSDSPGPKYPASQASRPQSFCPGCP----CPGSPGHQAPRPGP 693
           E G + SPG K  A +   P +  PG P     PG PG Q   PGP
Sbjct: 543 ETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGV-PGP 587



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 5/41 (12%)

Query: 676 PGCPCPGSPGHQAPRPG-PSVVDAAGLRSPCPGQHGAPASA 715
           PGC CP  P     RPG P    A G+    PG+ G+P  A
Sbjct: 115 PGCNCPPGPPGPTGRPGLPGDKGAIGM----PGRVGSPGDA 151


>gi|22027609 alpha 1 type XIII collagen isoform 19 [Homo sapiens]
          Length = 610

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/64 (32%), Positives = 25/64 (39%), Gaps = 9/64 (14%)

Query: 653 PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSP-----CPG 707
           PGP   PGP  P      P    P    PG PG   P+  P +    G +        PG
Sbjct: 221 PGPPGPPGPSGPLGHPGLPGPMGP----PGLPGPPGPKGDPGIQGYHGRKGERGMPGMPG 276

Query: 708 QHGA 711
           +HGA
Sbjct: 277 KHGA 280


>gi|22027607 alpha 1 type XIII collagen isoform 18 [Homo sapiens]
          Length = 655

 Score = 35.4 bits (80), Expect = 0.19
 Identities = 21/64 (32%), Positives = 25/64 (39%), Gaps = 9/64 (14%)

Query: 653 PGPSDSPGPKYPASQASRPQSFCPGCPCPGSPGHQAPRPGPSVVDAAGLRSP-----CPG 707
           PGP   PGP  P      P    P    PG PG   P+  P +    G +        PG
Sbjct: 210 PGPPGPPGPSGPLGHPGLPGPMGP----PGLPGPPGPKGDPGIQGYHGRKGERGMPGMPG 265

Query: 708 QHGA 711
           +HGA
Sbjct: 266 KHGA 269



 Score = 30.4 bits (67), Expect = 6.1
 Identities = 19/46 (41%), Positives = 22/46 (47%), Gaps = 5/46 (10%)

Query: 652 EPGPSDSPGPKYPASQASRPQSFCPGCP----CPGSPGHQAPRPGP 693
           E G + SPG K  A +   P +  PG P     PG PG Q   PGP
Sbjct: 481 ETGQAGSPGEKGEAGEKGNPGAEVPGLPGPEGPPGPPGLQGV-PGP 525


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.445 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,354,615
Number of Sequences: 37866
Number of extensions: 1680400
Number of successful extensions: 10574
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 238
Number of HSP's that attempted gapping in prelim test: 9353
Number of HSP's gapped (non-prelim): 1375
length of query: 726
length of database: 18,247,518
effective HSP length: 110
effective length of query: 616
effective length of database: 14,082,258
effective search space: 8674670928
effective search space used: 8674670928
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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