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Search of human proteins with 23065535
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
(667 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 1347 0.0
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 1331 0.0
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 1241 0.0
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 402 e-112
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 402 e-112
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 402 e-112
gi|21614542 single-minded homolog 1 [Homo sapiens] 228 1e-59
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 228 2e-59
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 228 2e-59
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 216 7e-56
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 208 1e-53
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 205 1e-52
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 121 2e-27
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 117 3e-26
gi|4758010 clock [Homo sapiens] 117 4e-26
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 112 8e-25
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 112 1e-24
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 112 1e-24
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 112 1e-24
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 110 5e-24
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 108 2e-23
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 97 4e-20
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 96 1e-19
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 71 3e-12
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 70 5e-12
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 70 5e-12
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 70 5e-12
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 69 1e-11
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 66 1e-10
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 66 1e-10
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 1347 bits (3485), Expect = 0.0
Identities = 667/667 (100%), Positives = 667/667 (100%)
Query: 1 MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60
MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS
Sbjct: 1 MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60
Query: 61 YLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQL 120
YLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQL
Sbjct: 61 YLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQL 120
Query: 121 ELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLK 180
ELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLK
Sbjct: 121 ELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLK 180
Query: 181 AATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFL 240
AATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFL
Sbjct: 181 AATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFL 240
Query: 241 SRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTG 300
SRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTG
Sbjct: 241 SRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTG 300
Query: 301 QYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR 360
QYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR
Sbjct: 301 QYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR 360
Query: 361 PIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPIL 420
PIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPIL
Sbjct: 361 PIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPIL 420
Query: 421 DGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDA 480
DGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDA
Sbjct: 421 DGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDA 480
Query: 481 DALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPR 540
DALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPR
Sbjct: 481 DALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPR 540
Query: 541 WGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHEN 600
WGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHEN
Sbjct: 541 WGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHEN 600
Query: 601 FLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPR 660
FLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPR
Sbjct: 601 FLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPR 660
Query: 661 AGSAQAD 667
AGSAQAD
Sbjct: 661 AGSAQAD 667
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 1331 bits (3445), Expect = 0.0
Identities = 662/664 (99%), Positives = 662/664 (99%)
Query: 4 QDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 63
Q RSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR
Sbjct: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLR 65
Query: 64 MHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
MHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI
Sbjct: 66 MHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 125
Query: 124 GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAAT 183
GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAAT
Sbjct: 126 GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAAT 185
Query: 184 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 243
WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH
Sbjct: 186 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 245
Query: 244 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 303
SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR
Sbjct: 246 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 305
Query: 304 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ 363
FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ
Sbjct: 306 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ 365
Query: 364 RGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGA 423
RGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGA
Sbjct: 366 RGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGA 425
Query: 424 SVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADAL 483
SVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADAL
Sbjct: 426 SVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADAL 485
Query: 484 DLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGS 543
DLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGS
Sbjct: 486 DLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGS 545
Query: 544 DPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLL 603
DPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLL
Sbjct: 546 DPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEHENFLL 605
Query: 604 FPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGS 663
FPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGS
Sbjct: 606 FPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPGGPFQPRAGS 665
Query: 664 AQAD 667
AQAD
Sbjct: 666 AQAD 669
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 1241 bits (3210), Expect = 0.0
Identities = 613/613 (100%), Positives = 613/613 (100%)
Query: 55 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 114
MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH
Sbjct: 1 MRLTISYLRMHRLCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKH 60
Query: 115 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 174
LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG
Sbjct: 61 LGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRG 120
Query: 175 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 234
RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL
Sbjct: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180
Query: 235 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 294
GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240
Query: 295 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 354
GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT
Sbjct: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300
Query: 355 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 414
EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR
Sbjct: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRR 360
Query: 415 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 474
LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL
Sbjct: 361 LLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDL 420
Query: 475 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 534
DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE
Sbjct: 421 DIAQDADALDLEMLAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALE 480
Query: 535 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 594
PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP
Sbjct: 481 PSLLPRWGSDPRLSCSSPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSP 540
Query: 595 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 654
SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG
Sbjct: 541 SPEHENFLLFPLSLSFLLTGGPAPGSLQDPSTPLLNLNEPLGLGPSLLSPYSDEDTTQPG 600
Query: 655 GPFQPRAGSAQAD 667
GPFQPRAGSAQAD
Sbjct: 601 GPFQPRAGSAQAD 613
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 402 bits (1034), Expect = e-112
Identities = 193/347 (55%), Positives = 259/347 (74%), Gaps = 2/347 (0%)
Query: 9 TTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLC 68
++E RKEKSRDAARSRRS+E+EV Y+LAH LP VS+HLDKAS+MRLTISYLR+ +L
Sbjct: 14 SSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLL 73
Query: 69 AAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIF 128
AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL GHS+F
Sbjct: 74 DAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVF 133
Query: 129 DFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLN 188
DF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRGRT+N+K+ATWKVL+
Sbjct: 134 DFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLH 193
Query: 189 CSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMK 248
C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL FLSRHSLDMK
Sbjct: 194 CTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMK 251
Query: 249 FTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARS 308
F+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ TGQYR LA+
Sbjct: 252 FSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKR 311
Query: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QTE
Sbjct: 312 GGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
Score = 53.5 bits (127), Expect = 6e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 374 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 433
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
Query: 434 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 487
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
Query: 488 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 547
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
Query: 548 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 598
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 402 bits (1034), Expect = e-112
Identities = 193/347 (55%), Positives = 259/347 (74%), Gaps = 2/347 (0%)
Query: 9 TTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLC 68
++E RKEKSRDAARSRRS+E+EV Y+LAH LP VS+HLDKAS+MRLTISYLR+ +L
Sbjct: 14 SSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLL 73
Query: 69 AAGEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIF 128
AG+ + ++ YLKAL+GFVMVLT +GDM Y+S+NV+K++GL+Q EL GHS+F
Sbjct: 74 DAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVF 133
Query: 129 DFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLN 188
DF HPCD EE+++ LT + L ++ E T+R F LRMK TLTSRGRT+N+K+ATWKVL+
Sbjct: 134 DFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLH 193
Query: 189 CSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMK 248
C+GH+ Y + G +PP+ CLVLICE IPHP ++E PL FLSRHSLDMK
Sbjct: 194 CTGHIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMK 251
Query: 249 FTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARS 308
F+YCD+RI E+ GY P++L+G S YEY HALDSD ++K+ H + +KGQ TGQYR LA+
Sbjct: 252 FSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKR 311
Query: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
GGY+W +TQATV+ + Q + IVCV++++S + + ++ SL+QTE
Sbjct: 312 GGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTE 358
Score = 53.5 bits (127), Expect = 6e-07
Identities = 70/234 (29%), Positives = 101/234 (43%), Gaps = 47/234 (20%)
Query: 374 NPGDSLDTPGPRILAFLHPPSLSEAALAADPRRFCSPDLRRLLGPILDGASVAATPSTPL 433
+P + +TP P + + P E AL +P S +L + I D + ST
Sbjct: 451 SPLPTAETPKP-LRSSADPALNQEVALKLEPNPE-SLELSFTMPQIQDQTPSPSDGSTRQ 508
Query: 434 ATRHPQSP------LSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALDLEM 487
++ P SP + +D+ +E + E V +LF +DTEA QD D LDLEM
Sbjct: 509 SSPEPNSPSEYCFYVDSDMVNEFKL--ELVEKLFA--EDTEAKNPFS--TQDTD-LDLEM 561
Query: 488 LAPYISMDDDFQLNASEQLPRAYHRPLGAVPRPRARSFHGLSPPALEPSLLPRWGSDPRL 547
LAPYI MDDDFQL RSF LSP LE S + P+
Sbjct: 562 LAPYIPMDDDFQL----------------------RSFDQLSP--LESSSASPESASPQS 597
Query: 548 SCS---SPSRGDPSASSPMAGARKRTLAQSSEDEDEGVELLGVRPPKRSPSPEH 598
+ + +P+A++ A L ++D E +++L SPSP H
Sbjct: 598 TVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKIL-----IASPSPTH 646
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 402 bits (1034), Expect = e-112
Identities = 235/545 (43%), Positives = 327/545 (60%), Gaps = 50/545 (9%)
Query: 2 DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61
D + RS++E RKEKSRDAAR RRS+ETEV Y+LAH LP VS+HLDKASIMRL IS+
Sbjct: 4 DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63
Query: 62 LRMHRLCAA--GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ 119
LR H+L ++ E + +D YLKALEGF+ V+T +GDM +LSEN+SK +GL+Q
Sbjct: 64 LRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQ 123
Query: 120 LELIGHSIFDFIHPCDQEELQDALTPQQT--LSRRKVEAPTERCFSLRMKSTLTSRGRTL 177
+EL GHSIFDF HPCD EE+++ L+ + ++ + TER F +RMK T+T+RGRT+
Sbjct: 124 VELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTV 183
Query: 178 NLKAATWKVLNCSGHMRAYKP-PAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGR 236
NLK+ATWKVL+C+G ++ Y P S G EP L CL+++CE I HP ++ PL
Sbjct: 184 NLKSATWKVLHCTGQVKVYNNCPPHNSLCGY--KEPLLSCLIIMCEPIQHPSHMDIPLDS 241
Query: 237 GAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQ 296
FLSRHS+DMKFTYCDDRI E+ GY P++L+G SAYE+ HALDS+ ++KS L +KGQ
Sbjct: 242 KTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQ 301
Query: 297 AVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQ 356
V+GQYR LA+ GGY+W +TQ TV+ R Q + I+CV++++S++E+ VV S++QTE
Sbjct: 302 VVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTES 361
Query: 357 HSRRPIQ----------RGAPSQKD-----------------TPNPGDSLDTPGPRILAF 389
+ + +GA S+K P PGD++ + F
Sbjct: 362 LFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEELAQLAPTPGDAIISLDFGNQNF 421
Query: 390 LHPPSLSEAAL------AADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLS 443
+ +A L A + R + L + A +TP AT S +
Sbjct: 422 EESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCST 481
Query: 444 ADLPDELPVGTEN------VHRLFTSGKDTEAVETDLDIAQDADALDLEMLAPYISMD-D 496
+ P++ +N + +LF DTEA + D + LDLE LAPYI MD +
Sbjct: 482 PNSPEDYYTSLDNDLKIEVIEKLF--AMDTEA-KDQCSTQTDFNELDLETLAPYIPMDGE 538
Query: 497 DFQLN 501
DFQL+
Sbjct: 539 DFQLS 543
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 228 bits (582), Expect = 1e-59
Identities = 135/350 (38%), Positives = 194/350 (55%), Gaps = 15/350 (4%)
Query: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEW 73
KEKS++AAR+RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 2 KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 74 NQVGAG---------GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 124
G G L + L+ L+GF+ V+ +G + Y+SE S HLGLSQ+EL G
Sbjct: 62 EAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTG 121
Query: 125 HSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAAT 183
+SI+++IHP D +E+ LT Q V E ER F LRMK L R L
Sbjct: 122 NSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNA--GLTCGG 179
Query: 184 WKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRH 243
+KV++CSG+++ + SP D LV + ++P E L F+ R
Sbjct: 180 YKVIHCSGYLKIRQYSLDMSPF---DGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRA 236
Query: 244 SLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYR 303
SLDMK + D R+AE+ GY P DLI + Y ++H D+ + + H LL KGQ T YR
Sbjct: 237 SLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYR 296
Query: 304 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 353
FLA+ GG++W Q+ AT+V R + IV V+++++ E G+ LSL+Q
Sbjct: 297 FLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQ 346
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 228 bits (580), Expect = 2e-59
Identities = 136/351 (38%), Positives = 199/351 (56%), Gaps = 17/351 (4%)
Query: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG-- 71
KEKS++AA++RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 72 -EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
W Q G PLD L+ L+GFV V+ ++G + Y+SE S HLGLSQ+EL
Sbjct: 62 DAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 124 GHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAA 182
G+SI+++IHP D +E+ LT Q L + E ER F LRMK L R L +
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNA--GLTCS 178
Query: 183 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 242
+KV++CSG+++ + S DS + LV + +++P E L F+ R
Sbjct: 179 GYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFR 235
Query: 243 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 302
SLD+K + D R+ EV GY P DLI + Y ++H D + + H LL KGQ T Y
Sbjct: 236 ASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYY 295
Query: 303 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 353
R L++ GG++W Q+ ATVV R + IV V+++++++E + LSLEQ
Sbjct: 296 RLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ 346
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 228 bits (580), Expect = 2e-59
Identities = 136/351 (38%), Positives = 199/351 (56%), Gaps = 17/351 (4%)
Query: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG-- 71
KEKS++AA++RR +E Y+LA LP +++ LDKASI+RLT SYL+M + G
Sbjct: 2 KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61
Query: 72 -EWNQVGAGGEPLDAC-------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
W Q G PLD L+ L+GFV V+ ++G + Y+SE S HLGLSQ+EL
Sbjct: 62 DAWGQPSRAG-PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 124 GHSIFDFIHPCDQEELQDALTPQQTLSRRKV-EAPTERCFSLRMKSTLTSRGRTLNLKAA 182
G+SI+++IHP D +E+ LT Q L + E ER F LRMK L R L +
Sbjct: 121 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNA--GLTCS 178
Query: 183 TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSR 242
+KV++CSG+++ + S DS + LV + +++P E L F+ R
Sbjct: 179 GYKVIHCSGYLKIRQYMLDMSLY---DSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFR 235
Query: 243 HSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQY 302
SLD+K + D R+ EV GY P DLI + Y ++H D + + H LL KGQ T Y
Sbjct: 236 ASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYY 295
Query: 303 RFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQ 353
R L++ GG++W Q+ ATVV R + IV V+++++++E + LSLEQ
Sbjct: 296 RLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQ 346
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 216 bits (549), Expect = 7e-56
Identities = 140/432 (32%), Positives = 221/432 (51%), Gaps = 71/432 (16%)
Query: 12 LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 71
LRKEKSRDAARSRR +E Y+LA LP +++ LDKASI+RLTISYL+M G
Sbjct: 21 LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
Query: 72 E--WNQVGAGGEP------------------------LDACYLKALEGFVMVLTAEGDMA 105
+ WN G P L + L++L+GFV L EG
Sbjct: 81 DPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFL 140
Query: 106 YLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL---------------------- 143
Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
Query: 144 --TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSG 191
+ Q+ + VE+ + ER F +RMKSTLT RG +++K++ +KV++ +G
Sbjct: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITG 258
Query: 192 HMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTY 251
+R + S + + LV++ A+P P E + F++R ++D+ Y
Sbjct: 259 RLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIY 313
Query: 252 CDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGY 311
C++RI++ +P D++G Y +IHA D + + S LL+KGQ VT YR++ ++GGY
Sbjct: 314 CENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGY 373
Query: 312 LWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKD 371
+W Q+ AT+ + ++I+ V++L+S E + + Q ++ + S +
Sbjct: 374 IWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP----EKTSESSET 429
Query: 372 TPNPGDSLDTPG 383
+ + DS DT G
Sbjct: 430 SDSESDSKDTSG 441
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 208 bits (530), Expect = 1e-53
Identities = 140/451 (31%), Positives = 221/451 (49%), Gaps = 90/451 (19%)
Query: 12 LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 71
LRKEKSRDAARSRR +E Y+LA LP +++ LDKASI+RLTISYL+M G
Sbjct: 21 LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
Query: 72 E--WNQVGAGGEP-------------------------------------------LDAC 86
+ WN G P L +
Sbjct: 81 DPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSH 140
Query: 87 YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--- 143
L++L+GFV L EG Y+SE VS +LGLSQ+EL G S+FD++HP D E+ + L
Sbjct: 141 ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 200
Query: 144 ---------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTS 172
+ Q+ + VE+ + ER F +RMKSTLT
Sbjct: 201 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 260
Query: 173 RGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEP 232
RG +++K++ +KV++ +G +R + S + + LV++ A+P P E
Sbjct: 261 RG--VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEV 313
Query: 233 PLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLL 292
+ F++R ++D+ YC++RI++ +P D++G Y +IHA D + + S LL
Sbjct: 314 RIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL 373
Query: 293 SKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLE 352
+KGQ VT YR++ ++GGY+W Q+ AT+ + ++I+ V++L+S E + +
Sbjct: 374 NKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIA 433
Query: 353 QTEQHSRRPIQRGAPSQKDTPNPGDSLDTPG 383
Q ++ + S + + + DS DT G
Sbjct: 434 QLPHLP----EKTSESSETSDSESDSKDTSG 460
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 205 bits (522), Expect = 1e-52
Identities = 141/437 (32%), Positives = 213/437 (48%), Gaps = 82/437 (18%)
Query: 13 RKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGE 72
RKEKSR+AARSRR +E ++LA LP +S+ LDKASI+RL+++YLR+ R A G
Sbjct: 46 RKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGA 105
Query: 73 --WNQVGAGG--------------------EPLDACYLKALEGFVMVLTAEGDMAYLSEN 110
W AG + L L++L+GFV L EG Y+SE
Sbjct: 106 PPWGLRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISET 165
Query: 111 VSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL--------------------------- 143
VS +LGLSQ+E+ G S+FD+IHP D E+ + L
Sbjct: 166 VSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLAD 225
Query: 144 TPQQTLSRRKVEAPT---ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPA 200
TP+ S KV + ER F +RMKSTLT RG L++KA+ +KV++ +G +RA+
Sbjct: 226 TPEIEASLTKVPPSSLVQERSFFVRMKSTLTKRG--LHVKASGYKVIHVTGRLRAHALG- 282
Query: 201 QTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVA 260
LV + +P E PL + R SL + C+ R+++
Sbjct: 283 ----------------LVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHM 326
Query: 261 GYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATV 320
P +L+G S Y+++H D+ + +S LL KGQ +TG YR+L R+GG++W Q+ ATV
Sbjct: 327 DLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWLQSVATV 386
Query: 321 VSGGRGPQSESIVCVHFLISQVE---------ETGVVLSLEQTEQHSRRPIQRGAPSQ-- 369
G+ P ++ V ++SQ E + ++ E+ P + P++
Sbjct: 387 AGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPEPPTEGK 446
Query: 370 KDTPNPGDSLDTPGPRI 386
+ P ++ T G RI
Sbjct: 447 QAAPAENEAPQTQGKRI 463
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 121 bits (303), Expect = 2e-27
Identities = 110/402 (27%), Positives = 183/402 (45%), Gaps = 50/402 (12%)
Query: 5 DHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRM 64
+H+ + +E + RR + ++ +L+ +P ++ LDK +++R+ + +LR
Sbjct: 100 EHQVKMKAFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRS 159
Query: 65 HRLCAAGEWNQ-VGAGGEP-------LDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115
+ G N VG+ P L LK EGF+ V+ E G + ++S++VSK L
Sbjct: 160 LK----GLTNSYVGSNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKIL 215
Query: 116 GLSQLELIGHSIFDFIHPCD---------------QEELQDALTPQQTLS-----RRKVE 155
Q L G S+FDF+HP D +E+L DA T Q S R +V
Sbjct: 216 NYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVY 275
Query: 156 APTERCFSLRMKSTLTS----RGRTLNLKAATWK---VLNCSGHMRAYKPP--AQTSPAG 206
+ + R F R+KS S G N K + ++C+G++R++ P
Sbjct: 276 SGSRRSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERN 335
Query: 207 SPDSEPPLQCLVLICEAIPH---PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYS 263
S CLV I P+ S E + F++R +++ KF Y D R + GY
Sbjct: 336 SKKDNSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYL 395
Query: 264 PDDLIGCSAYEYIHALD-SDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVS 322
P +L+G S YEY H D ++ K L SK + +T Y+F A+ G ++ ++Q +
Sbjct: 396 PQELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFT 455
Query: 323 GGRGPQSESIVCVHFLISQVEETG----VVLSLEQTEQHSRR 360
+ E IV V+ L+ E G + S + +E+ SR+
Sbjct: 456 NPWTKELEYIVSVNTLVLGHSEPGEASFLPCSSQSSEESSRQ 497
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 117 bits (294), Expect = 3e-26
Identities = 103/431 (23%), Positives = 187/431 (43%), Gaps = 73/431 (16%)
Query: 2 DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61
D +D ++ +E + R RR++ T+ + +L+ +P ++ DK +I+R+ +S+
Sbjct: 53 DDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSH 112
Query: 62 LRMHRLCAAGEWNQVGAGGEPLDACY--------------LKALEGFVMVLTAE-GDMAY 106
++ R G G + D Y L+A +GF+ V+ AE G + Y
Sbjct: 113 MKSMR----------GTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIY 162
Query: 107 LSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------- 158
+S++V+ L Q E G ++++ +HP D E+L++ L T + +++ R ++ T
Sbjct: 163 VSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEG 222
Query: 159 -----------ERCFSLRMK--------------STLTSRGRT----LNLKAATWKVLNC 189
R F RM+ +T+ R R + A + V++C
Sbjct: 223 QQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHC 282
Query: 190 SGHMRAYKPPAQTSPAGSPD-SEPPLQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHS 244
+G+++A+ P T P D + CLV I + P + FLSRH+
Sbjct: 283 TGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHN 342
Query: 245 LDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYR 303
D T+ D R V GY P DL+G E+ H D + +S ++ KGQ ++ YR
Sbjct: 343 SDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYR 402
Query: 304 FLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQ 363
F ++ ++ +T + + E I+C + + Q+++ L E H R +
Sbjct: 403 FRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAEL-----EVHQRDGLS 457
Query: 364 RGAPSQKDTPN 374
SQ PN
Sbjct: 458 SYDLSQVPVPN 468
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 117 bits (292), Expect = 4e-26
Identities = 97/384 (25%), Positives = 173/384 (45%), Gaps = 59/384 (15%)
Query: 14 KEKSRDAARS-----RRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLC 68
K+K++ +R+ RR Q ++ +L LP G + +DK+++++ +I +LR H+
Sbjct: 31 KDKAKRVSRNKSEKKRRDQFNVLIKELGSMLP---GNARKMDKSTVLQKSIDFLRKHKEI 87
Query: 69 AAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQL 120
A +W E L+AL+GF + + +G + Y+SE+V+ L
Sbjct: 88 TAQSDASEIRQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPS 147
Query: 121 ELIGHSIFDFIHPCDQEEL----------QDALTPQQTLSRRKVEAPTERCFSLRMKSTL 170
+L+ SIF+FI + E+ D+LTP+ S+ ++E F M
Sbjct: 148 DLVDQSIFNFIPEGEHSEVYKILSTHLLESDSLTPEYLKSKNQLE------FCCHML--- 198
Query: 171 TSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAG---------SPDSEPPLQCLVLIC 221
RG + +T++ + G+ ++ + ++ G P E + + +
Sbjct: 199 --RGTIDPKEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVR 256
Query: 222 EAIPH----PGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIH 277
A P ++E P F SRHSL+ KF + D R + GY P +++G S Y+Y H
Sbjct: 257 LATPQFIKEMCTVEEP--NEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYH 314
Query: 278 ALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHF 337
D + ++K L+ G+ + YRFL + ++W QT + + E IVC H
Sbjct: 315 VDDLENLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHT 374
Query: 338 LISQVE-------ETGVVLSLEQT 354
++S E E G+ SL +T
Sbjct: 375 VVSYAEVRAERRRELGIEESLPET 398
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 112 bits (281), Expect = 8e-25
Identities = 89/383 (23%), Positives = 173/383 (45%), Gaps = 48/383 (12%)
Query: 2 DWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISY 61
D Q L +E + R RR++ T + +L+ +P ++ DK +I+R+ +S+
Sbjct: 79 DEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSH 138
Query: 62 LRMHR----LCAAGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLG 116
++ R G + + L L+A +GF+ +++ E G + Y+S++V+ L
Sbjct: 139 MKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLN 198
Query: 117 LSQLELIGHSIFDFIHPCDQEELQDAL-TPQQTLSRRKVEAPT----------------- 158
Q E G +++D +HP D ++L++ L T + L+ R ++ T
Sbjct: 199 QPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMG 258
Query: 159 -ERCFSLRMKSTLTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPP 199
R F RM+ +S R R N + + V++C+G+++A+ P
Sbjct: 259 SRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPA 318
Query: 200 AQTSPAGSPDSEPPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD 254
+ P P++ + CLV I + P+ + F+SRH+++ FT+ D
Sbjct: 319 GVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDH 378
Query: 255 RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLW 313
R GY P +L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW
Sbjct: 379 RCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLW 438
Query: 314 TQTQATVVSGGRGPQSESIVCVH 336
+T + + E I+C +
Sbjct: 439 MRTSSFTFQNPYSDEIEYIICTN 461
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 112 bits (279), Expect = 1e-24
Identities = 87/356 (24%), Positives = 163/356 (45%), Gaps = 47/356 (13%)
Query: 1 MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60
+++ +H+ + +E + RR + + +LA +P +S LDK +++R+ +
Sbjct: 18 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 77
Query: 61 YLRMHRLCA----AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115
+++ R + + L L+A +GF+ V+ + G + ++SE+V K L
Sbjct: 78 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 137
Query: 116 GLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSR-RKVEAPT---------------- 158
SQ +LIG S+FD++HP D ++++ L+ T R R ++A T
Sbjct: 138 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 197
Query: 159 ---ERCFSLRMKSTLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAG 206
R F RMK S T + K ++ ++ +G+++++ P T
Sbjct: 198 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGL 254
Query: 207 SPDSEPP-----LQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 257
D+EP L CLV I +P P + E + ++SRH++D KF + D R
Sbjct: 255 DEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRAT 314
Query: 258 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 312
+ Y P +L+G S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 315 AILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 370
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 112 bits (279), Expect = 1e-24
Identities = 87/356 (24%), Positives = 163/356 (45%), Gaps = 47/356 (13%)
Query: 1 MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60
+++ +H+ + +E + RR + + +LA +P +S LDK +++R+ +
Sbjct: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
Query: 61 YLRMHRLCA----AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115
+++ R + + L L+A +GF+ V+ + G + ++SE+V K L
Sbjct: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
Query: 116 GLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSR-RKVEAPT---------------- 158
SQ +LIG S+FD++HP D ++++ L+ T R R ++A T
Sbjct: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
Query: 159 ---ERCFSLRMKSTLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAG 206
R F RMK S T + K ++ ++ +G+++++ P T
Sbjct: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGL 297
Query: 207 SPDSEPP-----LQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 257
D+EP L CLV I +P P + E + ++SRH++D KF + D R
Sbjct: 298 DEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRAT 357
Query: 258 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 312
+ Y P +L+G S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 358 AILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 413
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 112 bits (279), Expect = 1e-24
Identities = 87/356 (24%), Positives = 163/356 (45%), Gaps = 47/356 (13%)
Query: 1 MDWQDHRSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTIS 60
+++ +H+ + +E + RR + + +LA +P +S LDK +++R+ +
Sbjct: 61 LEYTEHQGRIKNAREAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQ 120
Query: 61 YLRMHRLCA----AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHL 115
+++ R + + L L+A +GF+ V+ + G + ++SE+V K L
Sbjct: 121 HMKTLRGATNPYTEANYKPTFLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKIL 180
Query: 116 GLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSR-RKVEAPT---------------- 158
SQ +LIG S+FD++HP D ++++ L+ T R R ++A T
Sbjct: 181 NYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLC 240
Query: 159 ---ERCFSLRMKSTLTSRG-------RTLNLKA--ATWKVLNCSGHMRAYKPPAQTSPAG 206
R F RMK S T + K ++ ++ +G+++++ P T
Sbjct: 241 SGARRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPP---TKMGL 297
Query: 207 SPDSEPP-----LQCLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 257
D+EP L CLV I +P P + E + ++SRH++D KF + D R
Sbjct: 298 DEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRAT 357
Query: 258 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ-YRFLARSGGYL 312
+ Y P +L+G S YEY H D +++ +L + +T Y+F + G ++
Sbjct: 358 AILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFI 413
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 110 bits (274), Expect = 5e-24
Identities = 86/371 (23%), Positives = 170/371 (45%), Gaps = 48/371 (12%)
Query: 14 KEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHR----LCA 69
+E + R RR++ T + +L+ +P ++ DK +I+R+ +S+++ R
Sbjct: 76 RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTST 135
Query: 70 AGEWNQVGAGGEPLDACYLKALEGFVMVLTAE-GDMAYLSENVSKHLGLSQLELIGHSIF 128
G + + L L+A +GF+ +++ E G + Y+S++V+ L Q E G +++
Sbjct: 136 DGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLY 195
Query: 129 DFIHPCDQEELQDAL-TPQQTLSRRKVEAPT------------------ERCFSLRMKST 169
D +HP D ++L++ L T + L+ R ++ T R F RM+
Sbjct: 196 DQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCG 255
Query: 170 LTS------------RGRTLNLKAAT------WKVLNCSGHMRAYKPPAQTSPAGSPDSE 211
+S R R N + + V++C+G+++A+ P + P P++
Sbjct: 256 SSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAG 315
Query: 212 PPLQ-CLVLI----CEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDD 266
+ CLV I + P+ + F+SRH+++ FT+ D R GY P +
Sbjct: 316 QGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQE 375
Query: 267 LIGCSAYEYIHALDSDAVSKSIHTLLS-KGQAVTGQYRFLARSGGYLWTQTQATVVSGGR 325
L+G + E+ H D + S ++ KGQ ++ +RF +++ +LW +T +
Sbjct: 376 LLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPY 435
Query: 326 GPQSESIVCVH 336
+ E I+C +
Sbjct: 436 SDEIEYIICTN 446
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 108 bits (270), Expect = 2e-23
Identities = 115/474 (24%), Positives = 200/474 (42%), Gaps = 54/474 (11%)
Query: 11 ELRKEKSRDAARS-----RRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMH 65
E K++++ A+R+ RR Q ++ +L+ LP G + +DK +++ I +L+ H
Sbjct: 3 EDEKDRAKRASRNKSEKKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGFLQKH 59
Query: 66 RLCAAG--------EWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGL 117
+A +W E L+AL+GF++ +T +G + Y+S++++ LG
Sbjct: 60 NEVSAQTEICDIQQDWKPSFLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSITPLLGH 119
Query: 118 SQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTL 177
+++ ++ +F+ + E+ L+ ++ + L L RG
Sbjct: 120 LPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL-RGSLN 178
Query: 178 NLKAATWKVLNCSGHMRAYKPPAQTSPAGSPD--SEP---PLQ---CLVLIC-----EAI 224
+ T++ + G+ R+Y S G + S P PL C + + +
Sbjct: 179 PKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFL 238
Query: 225 PHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAV 284
++ PL F SRHSL+ KF + D R + GY P +++G S Y+Y H D + +
Sbjct: 239 KEMCIVDEPLEE--FTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELL 296
Query: 285 SKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVE- 343
++ L+ G+ + YRFL + ++W QT + + E IVC H ++S +
Sbjct: 297 ARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADV 356
Query: 344 --ETGVVLSLEQTEQ---HSRRPIQRGAPSQKDTPNPGDSLDTPGPRILAFLHPPSLSEA 398
E L+LE HS +G S + ++LD G L H PS S
Sbjct: 357 RVERRQELALEDPPSEALHSSALKDKG--SSLEPRQHFNTLDV-GASGLNTSHSPSASSR 413
Query: 399 ALAADPRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPV 452
+ S P + A STP P SA LP ELPV
Sbjct: 414 SSHKSSHTAMSE-------PTSTPTKLMAEASTPAL------PRSATLPQELPV 454
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 97.4 bits (241), Expect = 4e-20
Identities = 93/350 (26%), Positives = 147/350 (42%), Gaps = 55/350 (15%)
Query: 16 KSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQ 75
KS + R R TE L +LA LPF + V LDK S++RL++SYLR +
Sbjct: 32 KSNPSKRHRDRLNTE-LDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSS 90
Query: 76 VGAGGEPLDAC----------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQ 119
D C L+AL GFV+V+T + + Y S + +LG Q
Sbjct: 91 PTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQ 150
Query: 120 LELIGHSIFDFIHPCDQEELQD----ALTPQQ-TLSRRKVEAPT---------------- 158
++I S+++ IH D+ E Q AL P Q T S + +E T
Sbjct: 151 SDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPP 210
Query: 159 ------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEP 212
ERCF R++ L + ++ + +N G ++ + GS P
Sbjct: 211 ENSPLMERCFICRLRCLLDN--------SSGFLAMNFQGKLKYLHGQKKKGKDGS--ILP 260
Query: 213 PLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDL-IGCS 271
P L I + P LE F ++H LD CD + V GY+ +L S
Sbjct: 261 PQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGS 320
Query: 272 AYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVV 321
Y++IHA D ++S ++ G++ +R L ++ + W Q+ A ++
Sbjct: 321 GYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLL 370
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 95.9 bits (237), Expect = 1e-19
Identities = 118/447 (26%), Positives = 181/447 (40%), Gaps = 45/447 (10%)
Query: 17 SRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQV 76
++ A+++RR Q + L LP A L IM L Y R A G +
Sbjct: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGG--TPL 62
Query: 77 GAGGEPLDACYLK----ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI--GHSIFDF 130
L A L+ AL GF++V TAEG + YLSE+VS+HLG S ++L+ G SI+D
Sbjct: 63 AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDI 122
Query: 131 IHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCS 190
I P D ++ LT L T+R F R ++ ++L ++A K++
Sbjct: 123 IDPADHLTVRQQLTLPSALD-------TDRLFRCRFNTS-----KSLRRQSAGNKLVLIR 170
Query: 191 GHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFT 250
G A+ P A AG+P L P PG L F SRH+ D+
Sbjct: 171 GRFHAHPPGAYW--AGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALL 228
Query: 251 YCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ--YRFLARS 308
+ + G+ +L+ S Y +H D S + LL++ + + R A++
Sbjct: 229 DISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKT 288
Query: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAP- 367
GG+ W G GP I ++ IS +E + L + + + G P
Sbjct: 289 GGWAWIYC-LLYSEGPEGP----ITANNYPISDMEAWSLRQQLNSEDTQAAYVL--GTPT 341
Query: 368 ----------SQKD--TPNPGDSLDTPGPRILAFLHPPSLSEAALAAD-PRRFCSPDLRR 414
SQ++ + NP + PR +F P LS + + + PR D
Sbjct: 342 MLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSY 401
Query: 415 LLGPILDGASVAATPSTPLATRHPQSP 441
L P S+ A S L P +P
Sbjct: 402 LTFPSGPEPSLQAELSKDLVCTPPYTP 428
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 71.2 bits (173), Expect = 3e-12
Identities = 105/465 (22%), Positives = 169/465 (36%), Gaps = 107/465 (23%)
Query: 15 EKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMH---RLCAAG 71
EKS + R R E L LA LPF + + LDK S++RL++SYLR+ ++
Sbjct: 32 EKSNPSKRHRDRLNAE-LDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQ 90
Query: 72 EWNQVGAGG-EPLDAC------------YLKALEGFVMVLTAEGDMAYLSENVSKHLGLS 118
Q AG P D+C L++L GF +V++AEG + Y S + +LG
Sbjct: 91 SSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFH 150
Query: 119 QLELIGHSIFDFIHPCDQE----ELQDALTPQQTLSRRK--------------------- 153
Q +++ +I+D+IH D++ +L A+ P Q + +
Sbjct: 151 QTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWG 210
Query: 154 VEAPTE------RCFSLRMKSTLTSRGRTLNLKAATWKVLNC----------SGHMRAYK 197
PTE RCF R++ L S L + W++ C G ++
Sbjct: 211 TGTPTEYSAFLTRCFICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLF 270
Query: 198 PPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIA 257
+ +P+G+ PP L I + P + E + ++ D T D ++
Sbjct: 271 GQKKKAPSGA--MLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAAT-ADAKVK 327
Query: 258 EVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQ 317
+L G Y + S+ L+ + Q G++ + L +
Sbjct: 328 ATTSLCESELHGKPNY------SAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGG 381
Query: 318 ATVV---SGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKDTPN 374
+V GG G + E EQH G +++TP
Sbjct: 382 PDLVLDPKGGSGDREE------------------------EQHRMLSRASGVTGRRETPG 417
Query: 375 PGDSL---------DTPGPRILAFLHPPSLSEAALAADPRRFCSP 410
P L D PR L P +L PR C P
Sbjct: 418 PTKPLPWTAGKHSEDGARPR----LQPSKNDPPSLRPMPRGSCLP 458
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 22 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 70
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
Query: 71 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
Query: 124 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 179
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
Query: 180 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 238
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
Query: 239 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 295
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
Query: 296 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
Query: 356 QHSRRPIQRGAPSQKDTPNP 375
+S I R PS + +P
Sbjct: 377 TNSGMSIPRVNPSVNPSISP 396
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 22 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 70
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
Query: 71 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
Query: 124 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 179
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
Query: 180 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 238
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
Query: 239 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 295
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
Query: 296 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
Query: 356 QHSRRPIQRGAPSQKDTPNP 375
+S I R PS + +P
Sbjct: 377 TNSGMSIPRVNPSVNPSISP 396
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 70.5 bits (171), Expect = 5e-12
Identities = 83/380 (21%), Positives = 149/380 (39%), Gaps = 42/380 (11%)
Query: 22 RSRRSQETEVLYQLAHTLPF----ARGVSAHLDKASIMRLTISYLRMHRLCAA------- 70
+ RR QE + L +LA L +S DK I++ T+ +++ +
Sbjct: 33 KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92
Query: 71 -------GEWNQVGAGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI 123
+Q E L L+AL+GF V+ EG + ++SENV+ +LG +Q EL+
Sbjct: 93 DVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELM 152
Query: 124 GHSIFDFIHPCDQEELQDALTPQQTLS----RRKVEAPTERCFSLRMKSTLTSRGRTLNL 179
S++ +H D E L P+ ++ ++ F+ RM T N
Sbjct: 153 NTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQ 212
Query: 180 KAA-TWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGA 238
+A ++V+ C + D E CL+ I +P P ++ G +
Sbjct: 213 EACQRYEVMQCF--------TVSQPKSIQEDGEDFQSCLICIARRLPRPPAI---TGVES 261
Query: 239 FLSRHSLDMKFTYCDDRIAEVAGYSP-DDLIGCSAYEYI--HALDSDAVSKSIHTLLSKG 295
F+++ K D AG + +DL+ Y + + + ++++G
Sbjct: 262 FMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRG 321
Query: 296 QAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTE 355
A + YRF+ G L T+ + I+ +H I E +G+ Q +
Sbjct: 322 TASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIH--IIDREHSGL---SPQDD 376
Query: 356 QHSRRPIQRGAPSQKDTPNP 375
+S I R PS + +P
Sbjct: 377 TNSGMSIPRVNPSVNPSISP 396
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 68.9 bits (167), Expect = 1e-11
Identities = 96/420 (22%), Positives = 172/420 (40%), Gaps = 62/420 (14%)
Query: 7 RSTTELRKE--------KSRDAARSRRSQETEVLYQLAHTLPFAR-----GVSAHLDKAS 53
R+ T RKE R+ + R QE + + +LA + FA + DK +
Sbjct: 13 RAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELI-FANFNDIDNFNFKPDKCA 71
Query: 54 IMRLTISYLRM---HRLCAAGEWNQV--------GAGGEPLDAC---YLKALEGFVMVLT 99
I++ T+ +R AA ++V G G DA L+AL+GF V+
Sbjct: 72 ILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVN 131
Query: 100 AEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTE 159
EG++ ++SENV+++L +Q EL+ S++ +H D E L P+ ++
Sbjct: 132 LEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPP 191
Query: 160 R----CFSLRM----KSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSE 211
R F+ RM G ++ + C A + P +
Sbjct: 192 RRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCF---------AVSQPKSIKEEG 242
Query: 212 PPLQ-CLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD---RIAEVAGYSPDDL 267
LQ CL+ + +P P +F +R L K T D R A G+ +DL
Sbjct: 243 EDLQSCLICVARRVPMKERPVLPSSE-SFTTRQDLQGKITSLDTSTMRAAMKPGW--EDL 299
Query: 268 IGCSAYEYIHALDSDAVS---KSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGG 324
+ ++ + ++VS + H +L +G A + YRF G + QT++ ++
Sbjct: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359
Query: 325 RGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR---PIQRGAPSQKD--TPNPGDSL 379
+ + ++ +H L E+ V++ + T Q + PI +P+ + + NPG +
Sbjct: 360 TTNEPQLVISLHML--HREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDM 417
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 65.9 bits (159), Expect = 1e-10
Identities = 89/405 (21%), Positives = 158/405 (39%), Gaps = 41/405 (10%)
Query: 22 RSRRSQETEVLYQLAH----TLPFARGVSAHLDKASIMRLTISYLRMHRL---------- 67
+ RR QE++ + +LA L + DK +I++ T+ +R +
Sbjct: 35 KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDD 94
Query: 68 CAAGEWNQVGAG---GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 124
+ + G G + L L+AL+GF+ V+ +G++ ++SENV+++L Q +L+
Sbjct: 95 VQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVN 154
Query: 125 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 184
S+++ +H D+++ L P+ T++ T+ R KS + +
Sbjct: 155 TSVYNILHEEDRKDFLKNL-PKSTVNGVSWTNETQ-----RQKSHTFNCRMLMKTPHDIL 208
Query: 185 KVLNCSGHMRAYKPPAQTSPAGSP-----DSEPPLQCLVLICEAIPHPGSLEPPLGRGAF 239
+ +N S MR Q P + E C++ + I G P +F
Sbjct: 209 EDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESF 267
Query: 240 LSRHSLDMKFTYCDD---RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH--TLLSK 294
++RH L K D R + G+ +D+I + D + S+ H
Sbjct: 268 ITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLN 325
Query: 295 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 354
G A T YRF G + QT++ + V HFL Q E+ G +
Sbjct: 326 GHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFL--QREQNGYRPNPNPV 383
Query: 355 EQHSRRPIQRGAPSQKD--TPNPGDSLDTPGPRILAFLHPPSLSE 397
Q R P+ G S + +P L P R P + +
Sbjct: 384 GQGIRPPM-AGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQ 427
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 65.9 bits (159), Expect = 1e-10
Identities = 89/405 (21%), Positives = 158/405 (39%), Gaps = 41/405 (10%)
Query: 22 RSRRSQETEVLYQLAH----TLPFARGVSAHLDKASIMRLTISYLRMHRL---------- 67
+ RR QE++ + +LA L + DK +I++ T+ +R +
Sbjct: 35 KRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDD 94
Query: 68 CAAGEWNQVGAG---GEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIG 124
+ + G G + L L+AL+GF+ V+ +G++ ++SENV+++L Q +L+
Sbjct: 95 VQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVN 154
Query: 125 HSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATW 184
S+++ +H D+++ L P+ T++ T+ R KS + +
Sbjct: 155 TSVYNILHEEDRKDFLKNL-PKSTVNGVSWTNETQ-----RQKSHTFNCRMLMKTPHDIL 208
Query: 185 KVLNCSGHMRAYKPPAQTSPAGSP-----DSEPPLQCLVLICEAIPHPGSLEPPLGRGAF 239
+ +N S MR Q P + E C++ + I G P +F
Sbjct: 209 EDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRIT-TGERTFPSNPESF 267
Query: 240 LSRHSLDMKFTYCDD---RIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIH--TLLSK 294
++RH L K D R + G+ +D+I + D + S+ H
Sbjct: 268 ITRHDLSGKVVNIDTNSLRSSMRPGF--EDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLN 325
Query: 295 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 354
G A T YRF G + QT++ + V HFL Q E+ G +
Sbjct: 326 GHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFL--QREQNGYRPNPNPV 383
Query: 355 EQHSRRPIQRGAPSQKD--TPNPGDSLDTPGPRILAFLHPPSLSE 397
Q R P+ G S + +P L P R P + +
Sbjct: 384 GQGIRPPM-AGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQ 427
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,452,290
Number of Sequences: 37866
Number of extensions: 1698405
Number of successful extensions: 6774
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 6432
Number of HSP's gapped (non-prelim): 439
length of query: 667
length of database: 18,247,518
effective HSP length: 109
effective length of query: 558
effective length of database: 14,120,124
effective search space: 7879029192
effective search space used: 7879029192
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.