Search of human proteins with 226874833

Search of human proteins with 226874833

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
         (197 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]              385   e-107
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]              385   e-107
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]                385   e-107
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]          129   1e-30
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]          114   7e-26
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]          109   1e-24
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]           109   2e-24
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]           108   4e-24
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]          107   5e-24
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]            107   9e-24
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...   102   2e-22
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...   102   2e-22
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...   101   5e-22
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...   101   5e-22
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           98   5e-21
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           98   5e-21
gi|186700629 calcium/calmodulin-dependent serine protein kinase ...    97   1e-20
gi|186700627 calcium/calmodulin-dependent serine protein kinase ...    97   1e-20
gi|186972120 calcium/calmodulin-dependent serine protein kinase ...    97   1e-20
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      95   3e-20
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      95   3e-20
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       95   3e-20
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]                      95   3e-20
gi|21389483 leucine-rich repeats and guanylate kinase domain con...    92   2e-19
gi|13129124 caspase recruitment domain protein 14 isoform 1 [Hom...    45   3e-05
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    42   4e-04
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    42   4e-04
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    42   4e-04
gi|218505835 membrane-associated guanylate kinase-related  3 iso...    41   6e-04
gi|155969695 membrane-associated guanylate kinase-related  3 iso...    41   6e-04

>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
          Length = 197

 Score =  385 bits (989), Expect = e-107
 Identities = 197/197 (100%), Positives = 197/197 (100%)

Query: 1   MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV 60
           MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
Sbjct: 1   MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV 60

Query: 61  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI 120
           MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
Sbjct: 61  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI 120

Query: 121 SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE 180
           SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
Sbjct: 121 SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE 180

Query: 181 LKEALSEEIKKAQRTGA 197
           LKEALSEEIKKAQRTGA
Sbjct: 181 LKEALSEEIKKAQRTGA 197


>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
          Length = 218

 Score =  385 bits (989), Expect = e-107
 Identities = 197/197 (100%), Positives = 197/197 (100%)

Query: 1   MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV 60
           MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
Sbjct: 22  MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV 81

Query: 61  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI 120
           MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
Sbjct: 82  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI 141

Query: 121 SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE 180
           SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
Sbjct: 142 SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE 201

Query: 181 LKEALSEEIKKAQRTGA 197
           LKEALSEEIKKAQRTGA
Sbjct: 202 LKEALSEEIKKAQRTGA 218


>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
          Length = 197

 Score =  385 bits (989), Expect = e-107
 Identities = 197/197 (100%), Positives = 197/197 (100%)

Query: 1   MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV 60
           MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV
Sbjct: 1   MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV 60

Query: 61  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI 120
           MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI
Sbjct: 61  MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI 120

Query: 121 SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE 180
           SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE
Sbjct: 121 SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE 180

Query: 181 LKEALSEEIKKAQRTGA 197
           LKEALSEEIKKAQRTGA
Sbjct: 181 LKEALSEEIKKAQRTGA 197


>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
          Length = 675

 Score =  129 bits (325), Expect = 1e-30
 Identities = 67/183 (36%), Positives = 105/183 (57%), Gaps = 1/183 (0%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           RP++L GP   G++ L +RL+ +    F  +V HTTR+ R  E  G+DY+FV+R+  + D
Sbjct: 480 RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEAD 539

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           IAAG FIEH EF  NLYGTS  +V+ V    +IC+L +  Q ++ ++ +DL+P  I + P
Sbjct: 540 IAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAP 599

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
           PS   L   L +     +   ++ +     +ME +     FD  I+N  LD+AY EL   
Sbjct: 600 PSQERLRALLAKEGKNPKPEELREIIEKTREMEQN-NGHYFDTAIVNSDLDKAYQELLRL 658

Query: 185 LSE 187
           +++
Sbjct: 659 INK 661


>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
          Length = 576

 Score =  114 bits (284), Expect = 7e-26
 Identities = 66/190 (34%), Positives = 108/190 (56%), Gaps = 14/190 (7%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           R VVL GP G G + L ++LL   +  +G +V HTTR  R  E +G +Y F+++ + + D
Sbjct: 369 RLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETD 428

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           +    FIE+ E+  N YGTS  +V++V A N++C+LDV    V++++  + +P  I ++P
Sbjct: 429 VQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKP 488

Query: 125 PSLHVLEQR------LRQRNTE------TEESLVKRLAAAQADMESSKEPGLFDVVIIND 172
           PS+  L +       +  R+ +      TEE   + + +AQ  +  S+   LFD +IIND
Sbjct: 489 PSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQ--IMESQYGHLFDKIIIND 546

Query: 173 SLDQAYAELK 182
            L  A+ ELK
Sbjct: 547 DLTVAFNELK 556


>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
          Length = 637

 Score =  109 bits (273), Expect = 1e-24
 Identities = 65/198 (32%), Positives = 113/198 (57%), Gaps = 11/198 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           R +VL GPSG G + L ++L++ +   F  +V HTTR  +  E NG++Y++V++E  +  
Sbjct: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENL 487

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           I +   +E+ E+ G+LYGTS  AVQ V    +ICV+D++ Q ++ ++  +L+P  I ++P
Sbjct: 488 IYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKP 547

Query: 125 PSLHVLEQRLRQRNTET---------EESLVKRLAAAQADMESSKEPGLFDVVIINDSLD 175
            ++  ++Q  +     T         +E L +    AQ  ME ++    FD VI+NDSL 
Sbjct: 548 SNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQR-ME-TQFGQFFDHVIVNDSLH 605

Query: 176 QAYAELKEALSEEIKKAQ 193
            A A+L  A+ +  ++ Q
Sbjct: 606 DACAQLLSAIQKAQEEPQ 623


>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
          Length = 552

 Score =  109 bits (272), Expect = 2e-24
 Identities = 57/192 (29%), Positives = 103/192 (53%), Gaps = 13/192 (6%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           + +VL G  G G+ +L  +L+      +G +V +T+R P+  E  G+ Y FV+R  M+ D
Sbjct: 351 KTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 410

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           + AG ++EH E+ GNLYGT   +++ V A  ++CVLDV+ Q V+ ++  +  P  + ++ 
Sbjct: 411 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEA 470

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPG---------LFDVVIINDSLD 175
           P      + LR  N    ES +      +AD+  + E            FD+ ++N +L+
Sbjct: 471 PDF----ETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLE 526

Query: 176 QAYAELKEALSE 187
           + + EL+ A+ +
Sbjct: 527 RTFRELQTAMEK 538


>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
          Length = 585

 Score =  108 bits (269), Expect = 4e-24
 Identities = 61/190 (32%), Positives = 104/190 (54%), Gaps = 9/190 (4%)

Query: 4   PRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQR 63
           PR VVL G  GA    L ++++ E+   FG +V HTTR  +  E+ G +Y+FV+++  + 
Sbjct: 385 PRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEA 444

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           D+    F+EH E+  NLYGTS  A+QAV A N++C++DV+ + ++ ++ ++ +P  I V+
Sbjct: 445 DLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVK 504

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKE------PGLFDVVIINDSLDQA 177
           P    + E+R     +   E         Q +M +S          L D V++ + L  A
Sbjct: 505 PA---IQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGA 561

Query: 178 YAELKEALSE 187
           Y++LK  L +
Sbjct: 562 YSQLKVVLEK 571


>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
          Length = 540

 Score =  107 bits (268), Expect = 5e-24
 Identities = 58/192 (30%), Positives = 105/192 (54%), Gaps = 13/192 (6%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           + +VL G  G G+ +L  R +  +   FG +V  T+R PR  E++G+ Y FV+R  M+ D
Sbjct: 339 KTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEAD 398

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           I AG ++EH E+ GNLYGT   ++  V    R C+LDV+ Q ++ ++ ++  P  + +  
Sbjct: 399 IKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAA 458

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPG---------LFDVVIINDSLD 175
           P L    + LR  +    ++ +       +D++ + +            FD++IIND+LD
Sbjct: 459 PEL----ETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLD 514

Query: 176 QAYAELKEALSE 187
           +A+ +L+ A+ +
Sbjct: 515 KAFEKLQTAIEK 526


>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
          Length = 466

 Score =  107 bits (266), Expect = 9e-24
 Identities = 58/191 (30%), Positives = 103/191 (53%), Gaps = 17/191 (8%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           + +VL G SG G+S +   LL ++   F + V +TTR PR  EE+GK+Y+F++ E M R+
Sbjct: 283 KTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRN 342

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           I+A +F+E   + GN++GT    V  +   N+I +LD++ Q ++ ++  +L P  + + P
Sbjct: 343 ISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP 402

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMES--SKEPGLFDVVIINDSLDQAYAELK 182
                       + T+TE      L   Q D E+  S+    FD+ ++N+ +D+   +L+
Sbjct: 403 ----------TDQGTQTE-----ALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQ 447

Query: 183 EALSEEIKKAQ 193
           EA  +     Q
Sbjct: 448 EAFDQACSSPQ 458


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score =  102 bits (255), Expect = 2e-22
 Identities = 61/185 (32%), Positives = 102/185 (55%), Gaps = 9/185 (4%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV-TREVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FV +RE M++
Sbjct: 323 RPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 379

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +F+ NLYGTS  +V+AV    + C+LDV    ++ ++   L PI I ++
Sbjct: 380 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 439

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKE 183
           P S+  L +  R++  E    +  +  A + + E  +    F  ++  DSL++ Y ++K+
Sbjct: 440 PKSIEALMEMNRRQTYEQANKIYDK--AMKLEQEFGE---YFTAIVQGDSLEEIYNKIKQ 494

Query: 184 ALSEE 188
            + ++
Sbjct: 495 IIEDQ 499


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score =  102 bits (255), Expect = 2e-22
 Identities = 61/185 (32%), Positives = 102/185 (55%), Gaps = 9/185 (4%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV-TREVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FV +RE M++
Sbjct: 628 RPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +F+ NLYGTS  +V+AV    + C+LDV    ++ ++   L PI I ++
Sbjct: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKE 183
           P S+  L +  R++  E    +  +  A + + E  +    F  ++  DSL++ Y ++K+
Sbjct: 745 PKSIEALMEMNRRQTYEQANKIYDK--AMKLEQEFGE---YFTAIVQGDSLEEIYNKIKQ 799

Query: 184 ALSEE 188
            + ++
Sbjct: 800 IIEDQ 804


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score =  101 bits (251), Expect = 5e-22
 Identities = 66/185 (35%), Positives = 102/185 (55%), Gaps = 11/185 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVT-REVMQR 63
           RP+++ GP+   K      LL E    FG  V HTTR  R  E +G+DY+FV+ RE M++
Sbjct: 578 RPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEK 634

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI A  FIE  +++ +LYGTS  +V+ V    + C+LDV    VR ++A  L PI I ++
Sbjct: 635 DIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIR 694

Query: 124 PPSL-HVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK 182
           P SL +VLE  + +R TE +     R A  +A     +    F  ++  DS ++ Y ++K
Sbjct: 695 PRSLENVLE--INKRITEEQ----ARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVK 748

Query: 183 EALSE 187
             + +
Sbjct: 749 RVIED 753


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score =  101 bits (251), Expect = 5e-22
 Identities = 66/185 (35%), Positives = 102/185 (55%), Gaps = 11/185 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVT-REVMQR 63
           RP+++ GP+   K      LL E    FG  V HTTR  R  E +G+DY+FV+ RE M++
Sbjct: 532 RPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEK 588

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI A  FIE  +++ +LYGTS  +V+ V    + C+LDV    VR ++A  L PI I ++
Sbjct: 589 DIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIR 648

Query: 124 PPSL-HVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK 182
           P SL +VLE  + +R TE +     R A  +A     +    F  ++  DS ++ Y ++K
Sbjct: 649 PRSLENVLE--INKRITEEQ----ARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVK 702

Query: 183 EALSE 187
             + +
Sbjct: 703 RVIED 707


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 97.8 bits (242), Expect = 5e-21
 Identities = 58/186 (31%), Positives = 99/186 (53%), Gaps = 11/186 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVT-REVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FVT RE M++
Sbjct: 715 RPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK 771

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +++ +LYGTS  +V+ V    + C+LDV    ++ ++   L PI I ++
Sbjct: 772 DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIK 831

Query: 124 PPSL-HVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK 182
           P S+ +++E   R    +  ++  + +   Q   E       F  ++  D+L+  Y ++K
Sbjct: 832 PKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEH------FTAIVQGDTLEDIYNQVK 885

Query: 183 EALSEE 188
           + + E+
Sbjct: 886 QIIEEQ 891


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 97.8 bits (242), Expect = 5e-21
 Identities = 58/186 (31%), Positives = 99/186 (53%), Gaps = 11/186 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVT-REVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FVT RE M++
Sbjct: 737 RPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEK 793

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +++ +LYGTS  +V+ V    + C+LDV    ++ ++   L PI I ++
Sbjct: 794 DIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIK 853

Query: 124 PPSL-HVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELK 182
           P S+ +++E   R    +  ++  + +   Q   E       F  ++  D+L+  Y ++K
Sbjct: 854 PKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEH------FTAIVQGDTLEDIYNQVK 907

Query: 183 EALSEE 188
           + + E+
Sbjct: 908 QIIEEQ 913


>gi|186700629 calcium/calmodulin-dependent serine protein kinase
           isoform 3 [Homo sapiens]
          Length = 897

 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 49/181 (27%), Positives = 93/181 (51%), Gaps = 10/181 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           + +VL G  G G+  +   L+ +H   F + + HTTR P+  EENGK+YYFV+ + M +D
Sbjct: 711 KTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQD 770

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           I+  +++E+      +YGT    ++ +     I +LDV+ Q ++ ++  +  P  + +  
Sbjct: 771 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 830

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
           P++              +ESL +     ++D+        FD+ IIN+ +D+    L+EA
Sbjct: 831 PTI--------TPGLNEDESLQR--LQKESDILQRTYAHYFDLTIINNEIDETIRHLEEA 880

Query: 185 L 185
           +
Sbjct: 881 V 881


>gi|186700627 calcium/calmodulin-dependent serine protein kinase
           isoform 2 [Homo sapiens]
          Length = 898

 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 49/181 (27%), Positives = 93/181 (51%), Gaps = 10/181 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           + +VL G  G G+  +   L+ +H   F + + HTTR P+  EENGK+YYFV+ + M +D
Sbjct: 712 KTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQD 771

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           I+  +++E+      +YGT    ++ +     I +LDV+ Q ++ ++  +  P  + +  
Sbjct: 772 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 831

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
           P++              +ESL +     ++D+        FD+ IIN+ +D+    L+EA
Sbjct: 832 PTI--------TPGLNEDESLQR--LQKESDILQRTYAHYFDLTIINNEIDETIRHLEEA 881

Query: 185 L 185
           +
Sbjct: 882 V 882


>gi|186972120 calcium/calmodulin-dependent serine protein kinase
           isoform 1 [Homo sapiens]
          Length = 921

 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 49/181 (27%), Positives = 93/181 (51%), Gaps = 10/181 (5%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
           + +VL G  G G+  +   L+ +H   F + + HTTR P+  EENGK+YYFV+ + M +D
Sbjct: 735 KTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQD 794

Query: 65  IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
           I+  +++E+      +YGT    ++ +     I +LDV+ Q ++ ++  +  P  + +  
Sbjct: 795 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 854

Query: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
           P++              +ESL +     ++D+        FD+ IIN+ +D+    L+EA
Sbjct: 855 PTI--------TPGLNEDESLQR--LQKESDILQRTYAHYFDLTIINNEIDETIRHLEEA 904

Query: 185 L 185
           +
Sbjct: 905 V 905


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 95.1 bits (235), Expect = 3e-20
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 9/185 (4%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV-TREVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FV +RE M++
Sbjct: 560 RPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 616

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +++ NLYGTS  +V+ V    + C+LDV    ++ ++   L PI I ++
Sbjct: 617 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 676

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKE 183
           P SL  L +  ++   E  +    R  A + + E  +    F  ++  D+L+  Y + K 
Sbjct: 677 PRSLEPLMEMNKRLTEEQAKKTYDR--AIKLEQEFGE---YFTAIVQGDTLEDIYNQCKL 731

Query: 184 ALSEE 188
            + E+
Sbjct: 732 VIEEQ 736


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 95.1 bits (235), Expect = 3e-20
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 9/185 (4%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV-TREVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FV +RE M++
Sbjct: 786 RPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 842

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +++ NLYGTS  +V+ V    + C+LDV    ++ ++   L PI I ++
Sbjct: 843 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 902

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKE 183
           P SL  L +  ++   E  +    R  A + + E  +    F  ++  D+L+  Y + K 
Sbjct: 903 PRSLEPLMEMNKRLTEEQAKKTYDR--AIKLEQEFGE---YFTAIVQGDTLEDIYNQCKL 957

Query: 184 ALSEE 188
            + E+
Sbjct: 958 VIEEQ 962


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 95.1 bits (235), Expect = 3e-20
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 9/185 (4%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV-TREVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FV +RE M++
Sbjct: 681 RPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 737

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +++ NLYGTS  +V+ V    + C+LDV    ++ ++   L PI I ++
Sbjct: 738 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 797

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKE 183
           P SL  L +  ++   E  +    R  A + + E  +    F  ++  D+L+  Y + K 
Sbjct: 798 PRSLEPLMEMNKRLTEEQAKKTYDR--AIKLEQEFGE---YFTAIVQGDTLEDIYNQCKL 852

Query: 184 ALSEE 188
            + E+
Sbjct: 853 VIEEQ 857


>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
          Length = 334

 Score = 95.1 bits (235), Expect = 3e-20
 Identities = 60/185 (32%), Positives = 97/185 (52%), Gaps = 9/185 (4%)

Query: 5   RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFV-TREVMQR 63
           RPV++ GP    K  +   L+ E    FG  V HTTR  R  E +G+DY+FV +RE M++
Sbjct: 145 RPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 201

Query: 64  DIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQ 123
           DI    FIE  +++ NLYGTS  +V+ V    + C+LDV    ++ ++   L PI I ++
Sbjct: 202 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 261

Query: 124 PPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKE 183
           P SL  L +  ++   E  +    R  A + + E  +    F  ++  D+L+  Y + K 
Sbjct: 262 PRSLEPLMEMNKRLTEEQAKKTYDR--AIKLEQEFGE---YFTAIVQGDTLEDIYNQCKL 316

Query: 184 ALSEE 188
            + E+
Sbjct: 317 VIEEQ 321


>gi|21389483 leucine-rich repeats and guanylate kinase domain
           containing [Homo sapiens]
          Length = 825

 Score = 92.4 bits (228), Expect = 2e-19
 Identities = 56/191 (29%), Positives = 96/191 (50%), Gaps = 6/191 (3%)

Query: 1   MSGPRPV-VLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTRE 59
           +  P P+ +L+GP   GK  L  RL ++ S  F +   HTTR P  GE +  DY+F++++
Sbjct: 410 LDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQD 469

Query: 60  VMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIY 119
           V    +  G FI    +  + YG ++  V+ +        + ++++GVR++K +   P Y
Sbjct: 470 VFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRY 529

Query: 120 ISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADME---SSKEPGLFDVVIINDSLDQ 176
           I V P +    E  LR++   +   +    A ++ D+    +   PG FD VI  D LD 
Sbjct: 530 ILVVPMNKEKYEGYLRRKGLFSRAEI--EFAVSRVDLYIKINQNFPGYFDEVINADDLDV 587

Query: 177 AYAELKEALSE 187
           AY +L + + E
Sbjct: 588 AYQKLSQLIRE 598


>gi|13129124 caspase recruitment domain protein 14 isoform 1 [Homo
           sapiens]
          Length = 1004

 Score = 45.4 bits (106), Expect = 3e-05
 Identities = 36/141 (25%), Positives = 70/141 (49%), Gaps = 7/141 (4%)

Query: 55  FVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATD 114
           ++++E  +     GD I+  E SG     ++ AV+++   N   +LDV L  V  +   D
Sbjct: 858 YLSQEEYEAWSQRGDIIQEGEVSGGRCWVTRHAVESLMEKNTHALLDVQLDSVCTLHRMD 917

Query: 115 LRP--IYISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIIN- 171
           + P  I++SV       L++ L++  T  E+ L    AA Q + +  + P L+  +  + 
Sbjct: 918 IFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLE---AARQEEGDLDRAPCLYSSLAPDG 974

Query: 172 -DSLDQAYAELKEALSEEIKK 191
              LD   + +++A+++E KK
Sbjct: 975 WSDLDGLLSCVRQAIADEQKK 995


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 41.6 bits (96), Expect = 4e-04
 Identities = 23/61 (37%), Positives = 32/61 (52%)

Query: 31  IFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQA 90
           ++  +V  TTR+PR GE  G DY F+T +       +G  +E   + GN YGT K   Q 
Sbjct: 137 LYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQP 196

Query: 91  V 91
           V
Sbjct: 197 V 197


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 41.6 bits (96), Expect = 4e-04
 Identities = 23/61 (37%), Positives = 32/61 (52%)

Query: 31  IFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQA 90
           ++  +V  TTR+PR GE  G DY F+T +       +G  +E   + GN YGT K   Q 
Sbjct: 137 LYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQP 196

Query: 91  V 91
           V
Sbjct: 197 V 197


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
           containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 41.6 bits (96), Expect = 4e-04
 Identities = 23/61 (37%), Positives = 32/61 (52%)

Query: 31  IFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSKVAVQA 90
           ++  +V  TTR+PR GE  G DY F+T +       +G  +E   + GN YGT K   Q 
Sbjct: 137 LYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQP 196

Query: 91  V 91
           V
Sbjct: 197 V 197


>gi|218505835 membrane-associated guanylate kinase-related  3
           isoform 1 [Homo sapiens]
          Length = 1481

 Score = 41.2 bits (95), Expect = 6e-04
 Identities = 20/47 (42%), Positives = 26/47 (55%)

Query: 39  TTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSK 85
           TTR PR GE  G DY F++ E  +    +G  +E   + GN YGT K
Sbjct: 146 TTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPK 192


>gi|155969695 membrane-associated guanylate kinase-related  3
           isoform 2 [Homo sapiens]
          Length = 1125

 Score = 41.2 bits (95), Expect = 6e-04
 Identities = 20/47 (42%), Positives = 26/47 (55%)

Query: 39  TTRNPRPGEENGKDYYFVTREVMQRDIAAGDFIEHAEFSGNLYGTSK 85
           TTR PR GE  G DY F++ E  +    +G  +E   + GN YGT K
Sbjct: 146 TTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPK 192


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,185,799
Number of Sequences: 37866
Number of extensions: 295369
Number of successful extensions: 1517
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 18
Number of HSP's that attempted gapping in prelim test: 1399
Number of HSP's gapped (non-prelim): 112
length of query: 197
length of database: 18,247,518
effective HSP length: 97
effective length of query: 100
effective length of database: 14,574,516
effective search space: 1457451600
effective search space used: 1457451600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.