Guide to the Human Genome
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Search of human proteins with 226529806

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
         (649 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]         1308   0.0  
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]          1296   0.0  
gi|13128864 histone deacetylase 6 [Homo sapiens]                      368   e-101
gi|153085395 histone deacetylase 4 [Homo sapiens]                     207   2e-53
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]            204   3e-52
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]            204   3e-52
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]            202   8e-52
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]            202   8e-52
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]           197   2e-50
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]           197   2e-50
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]            192   6e-49
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]            140   5e-33
gi|13128860 histone deacetylase 1 [Homo sapiens]                       79   2e-14
gi|116284376 histone deacetylase 2 [Homo sapiens]                      78   3e-14
gi|8923769 histone deacetylase 8 [Homo sapiens]                        70   6e-12
gi|13128862 histone deacetylase 3 [Homo sapiens]                       66   1e-10
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]           53   8e-07
gi|222418647 mucin 7, secreted precursor [Homo sapiens]                47   7e-05
gi|222418649 mucin 7, secreted precursor [Homo sapiens]                47   7e-05
gi|222418645 mucin 7, secreted precursor [Homo sapiens]                47   7e-05
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]           46   9e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    41   0.004
gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]       40   0.005
gi|239754940 PREDICTED: hypothetical protein [Homo sapiens]            40   0.007
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    39   0.015
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    39   0.015
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    39   0.015
gi|150170670 piccolo isoform 2 [Homo sapiens]                          39   0.020
gi|150378539 piccolo isoform 1 [Homo sapiens]                          39   0.020
gi|116284392 mucin 2 precursor [Homo sapiens]                          37   0.074

>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
          Length = 649

 Score = 1308 bits (3385), Expect = 0.0
 Identities = 649/649 (100%), Positives = 649/649 (100%)

Query: 1   MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60
           MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
Sbjct: 1   MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60

Query: 61  GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120
           GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
Sbjct: 61  GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120

Query: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
           AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
Sbjct: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180

Query: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240
           YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
Sbjct: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240

Query: 241 AFLHLLLPLAFEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQT 300
           AFLHLLLPLAFEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQT
Sbjct: 241 AFLHLLLPLAFEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQT 300

Query: 301 LLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPP 360
           LLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPP
Sbjct: 301 LLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPP 360

Query: 361 LLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREE 420
           LLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREE
Sbjct: 361 LLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREE 420

Query: 421 TEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLS 480
           TEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLS
Sbjct: 421 TEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLS 480

Query: 481 HGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCIL 540
           HGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCIL
Sbjct: 481 HGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCIL 540

Query: 541 GLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGI 600
           GLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGI
Sbjct: 541 GLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGI 600

Query: 601 LARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA 649
           LARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
Sbjct: 601 LARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA 649


>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
          Length = 669

 Score = 1296 bits (3354), Expect = 0.0
 Identities = 649/669 (97%), Positives = 649/669 (97%), Gaps = 20/669 (2%)

Query: 1   MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60
           MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
Sbjct: 1   MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60

Query: 61  GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120
           GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
Sbjct: 61  GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120

Query: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
           AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
Sbjct: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180

Query: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240
           YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
Sbjct: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240

Query: 241 AFLHLLLPLAFE--------------------GQMQATPECFAHLTQLLQVLAGGRVCAV 280
           AFLHLLLPLAFE                    GQMQATPECFAHLTQLLQVLAGGRVCAV
Sbjct: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300

Query: 281 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 340
           LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
Sbjct: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360

Query: 341 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 400
           DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
Sbjct: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420

Query: 401 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 460
           ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
Sbjct: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480

Query: 461 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 520
           ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
Sbjct: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540

Query: 521 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 580
           MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
Sbjct: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600

Query: 581 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 640
           AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
Sbjct: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660

Query: 641 LQCHPHLVA 649
           LQCHPHLVA
Sbjct: 661 LQCHPHLVA 669


>gi|13128864 histone deacetylase 6 [Homo sapiens]
          Length = 1215

 Score =  368 bits (944), Expect = e-101
 Identities = 190/388 (48%), Positives = 250/388 (64%), Gaps = 28/388 (7%)

Query: 2   GTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELG 61
           GT LV  E +     LWDD   E   PERL A  ++L Q GL  RC+   AR A +EEL 
Sbjct: 85  GTGLVLDEQLNEFHCLWDDSFPE--GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELM 142

Query: 62  LVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGA 121
           LVHS EY+ L+  TQ + + EL+ L+  +D++Y HP+++ CA LA+G+ L+LVDAVL   
Sbjct: 143 LVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAE 202

Query: 122 VQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQY 181
           ++NG+A++RPPGHH Q +  +G+C+FN+VA+AA +A+QKH + R+L+VDWDVHHGQG Q+
Sbjct: 203 IRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQF 262

Query: 182 LFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAA 241
            F+ DPSVLYFS HRYE GRFWP L+ S+    G GQG G+T+N+PWNQVGM +ADY+AA
Sbjct: 263 TFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAA 322

Query: 242 FLHLLLPLAFE--------------------GQMQATPECFAHLTQLLQVLAGGRVCAVL 281
           FLH+LLP+A E                    G+M ATP  FA LT LL  LAGG++   L
Sbjct: 323 FLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSL 382

Query: 282 EGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQD 341
           EGGY+L +LAE V  ++ TLLGDP P L  P APC+SA  S+  A  A  P W+ L +  
Sbjct: 383 EGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRST 442

Query: 342 VTA----VPMSPSSHSPEGRP--PPLLP 363
            T     +       S E  P  PP+LP
Sbjct: 443 ETVERDNMEEDNVEESEEEGPWEPPVLP 470



 Score =  318 bits (816), Expect = 7e-87
 Identities = 172/361 (47%), Positives = 223/361 (61%), Gaps = 23/361 (6%)

Query: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
           T LVY ++M     LWD    E+  P+R+   + RL + GL  RCL L+ R A+E EL  
Sbjct: 481 TGLVYDQNMMNHCNLWDSHHPEV--PQRILRIMCRLEELGLAGRCLTLTPRPATEAELLT 538

Query: 63  VHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAV 122
            HS EYV  +R T+ +   EL   S  FD+IY  PSTF CA+LA GA  +LV+AVL+G V
Sbjct: 539 CHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEV 598

Query: 123 QNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHG-LHRILVVDWDVHHGQGIQY 181
            NG A+VRPPGHH ++ AA GFC FN+VA+AA HA+   G   RIL+VDWDVHHG G Q+
Sbjct: 599 LNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQH 658

Query: 182 LFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAA 241
           +FEDDPSVLY S HRY+HG F+P   E  +  +GR  G GFTVN+ WN   MG+ADY+AA
Sbjct: 659 MFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAA 718

Query: 242 FLHLLLPLAFE--------------------GQMQATPECFAHLTQLLQVLAGGRVCAVL 281
           +  L+LP+A+E                    G  Q +PE +AHLT LL  LA GR+  +L
Sbjct: 719 WHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILIL 778

Query: 282 EGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQD 341
           EGGY+L S++ES+    ++LLGDP P L+ P  P   AL SI         +W+SL+   
Sbjct: 779 EGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMK 838

Query: 342 V 342
           V
Sbjct: 839 V 839



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 34/85 (40%), Positives = 43/85 (50%), Gaps = 13/85 (15%)

Query: 542 LVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRGLAGGRVLALLEE- 591
           LVLP+AY F P+LVLV+ G       P  G Q  P   A L  +L GLA GR++ +LE  
Sbjct: 722 LVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGG 781

Query: 592 ---NSTPQLAGILARVLNGEAPPSL 613
               S  +      R L G+ PP L
Sbjct: 782 YNLTSISESMAACTRSLLGDPPPLL 806



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 38/121 (31%), Positives = 55/121 (45%), Gaps = 15/121 (12%)

Query: 535 FLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAA----------MLRGLAGGR 584
           +++  L ++LP+A  FQP LVLVA G    LQG     +AA          +L GLAGG+
Sbjct: 319 YIAAFLHVLLPVALEFQPQLVLVAAG-FDALQGDPKGEMAATPAGFAQLTHLLMGLAGGK 377

Query: 585 VLALLE--ENSTPQLAGILA--RVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 640
           ++  LE   N      G+ A    L G+  P L            ++      LEP W++
Sbjct: 378 LILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEV 437

Query: 641 L 641
           L
Sbjct: 438 L 438


>gi|153085395 histone deacetylase 4 [Homo sapiens]
          Length = 1084

 Score =  207 bits (528), Expect = 2e-53
 Identities = 133/387 (34%), Positives = 194/387 (50%), Gaps = 47/387 (12%)

Query: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
            T LVY   M   +          E   R+ +   RL++ GL  +C  +  R+A+ EEL  
Sbjct: 654  TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQT 713

Query: 63   VHSPEYVSL-----VRETQVLGKEELQALSGQF------------DAIYFHPSTFHCARL 105
            VHS  +  L     +   ++  K+ L +L+  F            D I+    +   ARL
Sbjct: 714  VHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARL 773

Query: 106  AAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHR 165
            A G  ++LV  V TG ++NG A+VRPPGHH + +   GFC FN+VA+AA   +Q+  + +
Sbjct: 774  AVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSK 833

Query: 166  ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVN 225
            IL+VDWDVHHG G Q  F  DPSVLY S HRY+ G F+P       D VG G G+GF VN
Sbjct: 834  ILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVN 891

Query: 226  LPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQATPE 260
            + +       MG+A+Y+AAF  +++P+A E                      G    +  
Sbjct: 892  MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951

Query: 261  CFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLG---DPAPPLSGPMAPCQ 317
            CF +LT+ L  LAGGR+   LEGG+ L ++ ++    V  LLG   DP P       P  
Sbjct: 952  CFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA 1011

Query: 318  SALESIQSARAAQAPHWKSLQQQDVTA 344
            +A+ S++      + +W+ LQ+   TA
Sbjct: 1012 NAVRSMEKVMEIHSKYWRCLQRTTSTA 1038



 Score = 37.7 bits (86), Expect = 0.033
 Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 11/73 (15%)

Query: 529 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 577
           P+    +L+    +V+P+A  F PD+VLV+ G            G+ L       L   L
Sbjct: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960

Query: 578 RGLAGGRVLALLE 590
            GLAGGR++  LE
Sbjct: 961 MGLAGGRIVLALE 973


>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
          Length = 1123

 Score =  204 bits (518), Expect = 3e-52
 Identities = 122/384 (31%), Positives = 192/384 (50%), Gaps = 50/384 (13%)

Query: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
            T +VY   M   + +  +     E   R+ +   RL++ GL  +C R+  R+A+ +E+  
Sbjct: 684  TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 743

Query: 63   VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103
            VHS EY +L+  T  L +++L +                   +    D ++    +    
Sbjct: 744  VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 802

Query: 104  RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
            R+A G  L+L   V  G ++NG A++RPPGHH + + A GFC FN+VAI A   +QK  +
Sbjct: 803  RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 862

Query: 164  HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
             ++L+VDWD+HHG G Q  F +DPSVLY S HRY++G F+P       + VG G G+G+ 
Sbjct: 863  GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 920

Query: 224  VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
            VN+ W       +G+ +Y+ AF  +++P+A E                      G    T
Sbjct: 921  VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 980

Query: 259  PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
              CF HLT+ L  LAGGRV   LEGG+ L ++ ++    V  LL     PL   +    P
Sbjct: 981  ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1040

Query: 316  CQSALESIQSARAAQAPHWKSLQQ 339
              +A+ +++     Q+ HW  +Q+
Sbjct: 1041 NINAVATLEKVIEIQSKHWSCVQK 1064



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%)

Query: 529  PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 577
            P+    +L+    +V+P+A+ F PD+VLV+ G            G+ +       L   L
Sbjct: 932  PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 991

Query: 578  RGLAGGRVLALLE 590
              LAGGRV+  LE
Sbjct: 992  MTLAGGRVVLALE 1004


>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
          Length = 1122

 Score =  204 bits (518), Expect = 3e-52
 Identities = 122/384 (31%), Positives = 192/384 (50%), Gaps = 50/384 (13%)

Query: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
            T +VY   M   + +  +     E   R+ +   RL++ GL  +C R+  R+A+ +E+  
Sbjct: 683  TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 742

Query: 63   VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103
            VHS EY +L+  T  L +++L +                   +    D ++    +    
Sbjct: 743  VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 801

Query: 104  RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
            R+A G  L+L   V  G ++NG A++RPPGHH + + A GFC FN+VAI A   +QK  +
Sbjct: 802  RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 861

Query: 164  HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
             ++L+VDWD+HHG G Q  F +DPSVLY S HRY++G F+P       + VG G G+G+ 
Sbjct: 862  GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 919

Query: 224  VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
            VN+ W       +G+ +Y+ AF  +++P+A E                      G    T
Sbjct: 920  VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 979

Query: 259  PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
              CF HLT+ L  LAGGRV   LEGG+ L ++ ++    V  LL     PL   +    P
Sbjct: 980  ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1039

Query: 316  CQSALESIQSARAAQAPHWKSLQQ 339
              +A+ +++     Q+ HW  +Q+
Sbjct: 1040 NINAVATLEKVIEIQSKHWSCVQK 1063



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%)

Query: 529  PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 577
            P+    +L+    +V+P+A+ F PD+VLV+ G            G+ +       L   L
Sbjct: 931  PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 990

Query: 578  RGLAGGRVLALLE 590
              LAGGRV+  LE
Sbjct: 991  MTLAGGRVVLALE 1003


>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
          Length = 1069

 Score =  202 bits (514), Expect = 8e-52
 Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%)

Query: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
            T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 636  TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695

Query: 63   VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
            VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 696  VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754

Query: 104  RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
            R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 755  RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814

Query: 164  HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
             +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P       + VG G G G+ 
Sbjct: 815  SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872

Query: 224  VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
            +N+ W       MG+ +Y+ AF  ++ P+A E                      G  + T
Sbjct: 873  INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932

Query: 259  PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
             +CF HLT+ L  LA GRV   LEGG+ L ++ ++    V  LLG+   PL+  +   +P
Sbjct: 933  AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992

Query: 316  CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346
              +A+ S+Q     Q+ +WKS++   + AVP
Sbjct: 993  NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020


>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
          Length = 1066

 Score =  202 bits (514), Expect = 8e-52
 Identities = 130/391 (33%), Positives = 197/391 (50%), Gaps = 53/391 (13%)

Query: 3    TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
            T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 633  TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692

Query: 63   VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
            VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 693  VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751

Query: 104  RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
            R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 752  RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811

Query: 164  HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
             +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P       + VG G G G+ 
Sbjct: 812  SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869

Query: 224  VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
            +N+ W       MG+ +Y+ AF  ++ P+A E                      G  + T
Sbjct: 870  INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929

Query: 259  PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
             +CF HLT+ L  LA GRV   LEGG+ L ++ ++    V  LLG+   PL+  +   +P
Sbjct: 930  AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989

Query: 316  CQSALESIQSARAAQAPHWKSLQQQDVTAVP 346
              +A+ S+Q     Q+ +WKS++   + AVP
Sbjct: 990  NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017


>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
          Length = 954

 Score =  197 bits (502), Expect = 2e-50
 Identities = 131/383 (34%), Positives = 186/383 (48%), Gaps = 48/383 (12%)

Query: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
           T L+Y   M   +    D     E   R+ +   RL++RGL  +C  L  R+AS EEL  
Sbjct: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581

Query: 63  VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104
           VHS  +V L     +    L   +L  L  Q               D I+    + + AR
Sbjct: 582 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 641

Query: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164
            AAG+   L   V +  ++NG A+VRPPGHH   + A GFC FN+VAIA    +Q+    
Sbjct: 642 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 701

Query: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224
           +IL+VDWDVHHG G Q  F  DPSVLY S HR++ G F+P       D VG G G GF V
Sbjct: 702 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 759

Query: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQATP 259
           N+ W       MG+ +Y+AAF  +++P+A E                      G    + 
Sbjct: 760 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 819

Query: 260 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 316
           +CF ++TQ L  LAGG V   LEGG+ L ++ ++    V  LLG+   PLS       P 
Sbjct: 820 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 879

Query: 317 QSALESIQSARAAQAPHWKSLQQ 339
            +A+ S+++     + +W  +Q+
Sbjct: 880 LNAIRSLEAVIRVHSKYWGCMQR 902



 Score = 33.1 bits (74), Expect = 0.82
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 535 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 583
           +L+    +V+P+A  F PDLVLV+ G     GH   L G H +      +   L  LAGG
Sbjct: 776 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 835

Query: 584 RVLALLE 590
            V+  LE
Sbjct: 836 AVVLALE 842


>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
          Length = 991

 Score =  197 bits (502), Expect = 2e-50
 Identities = 131/383 (34%), Positives = 186/383 (48%), Gaps = 48/383 (12%)

Query: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
           T L+Y   M   +    D     E   R+ +   RL++RGL  +C  L  R+AS EEL  
Sbjct: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618

Query: 63  VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104
           VHS  +V L     +    L   +L  L  Q               D I+    + + AR
Sbjct: 619 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 678

Query: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164
            AAG+   L   V +  ++NG A+VRPPGHH   + A GFC FN+VAIA    +Q+    
Sbjct: 679 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 738

Query: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224
           +IL+VDWDVHHG G Q  F  DPSVLY S HR++ G F+P       D VG G G GF V
Sbjct: 739 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 796

Query: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQATP 259
           N+ W       MG+ +Y+AAF  +++P+A E                      G    + 
Sbjct: 797 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 856

Query: 260 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 316
           +CF ++TQ L  LAGG V   LEGG+ L ++ ++    V  LLG+   PLS       P 
Sbjct: 857 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 916

Query: 317 QSALESIQSARAAQAPHWKSLQQ 339
            +A+ S+++     + +W  +Q+
Sbjct: 917 LNAIRSLEAVIRVHSKYWGCMQR 939



 Score = 33.1 bits (74), Expect = 0.82
 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)

Query: 535 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 583
           +L+    +V+P+A  F PDLVLV+ G     GH   L G H +      +   L  LAGG
Sbjct: 813 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 872

Query: 584 RVLALLE 590
            V+  LE
Sbjct: 873 AVVLALE 879


>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
          Length = 1011

 Score =  192 bits (489), Expect = 6e-49
 Identities = 123/369 (33%), Positives = 185/369 (50%), Gaps = 50/369 (13%)

Query: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
           T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692

Query: 63  VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
           VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751

Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
           R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811

Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
            +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P       + VG G G G+ 
Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869

Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
           +N+ W       MG+ +Y+ AF  ++ P+A E                      G  + T
Sbjct: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929

Query: 259 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
            +CF HLT+ L  LA GRV   LEGG+ L ++ ++    V  LLG+   PL+  +   +P
Sbjct: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989

Query: 316 CQSALESIQ 324
             +A+ S+Q
Sbjct: 990 NMNAVISLQ 998


>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
          Length = 879

 Score =  140 bits (352), Expect = 5e-33
 Identities = 80/221 (36%), Positives = 117/221 (52%), Gaps = 20/221 (9%)

Query: 3   TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
           T + Y   M   + +  +     E   R+ +   RL++ GL  +C R+  R+AS EE+ L
Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692

Query: 63  VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
           VHS E+ SL+  T  L  ++L                     L    D I+    +   A
Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751

Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
           R+A G  ++L   V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + +  +
Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811

Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWP 204
            +IL+VD DVHHG G Q  F  DPS+LY S HRY+ G F+P
Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852


>gi|13128860 histone deacetylase 1 [Homo sapiens]
          Length = 482

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 58/220 (26%), Positives = 100/220 (45%), Gaps = 13/220 (5%)

Query: 27  RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86
           +P R+    + L   GL ++       +A+ EE+   HS +Y+  +R  +     E    
Sbjct: 31  KPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ 90

Query: 87  SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142
             +F+     P     F   +L+ G  +    AV     Q  +A+    G HH +++ A+
Sbjct: 91  MQRFNVGEDCPVFDGLFEFCQLSTGGSV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEAS 148

Query: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
           GFC  N++ +A     + H   R+L +D D+HHG G++  F     V+  S+H+Y  G +
Sbjct: 149 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 204

Query: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAF 242
           +P     D   +G G+G  + VN P    G+ +  Y A F
Sbjct: 205 FP--GTGDLRDIGAGKGKYYAVNYPLRD-GIDDESYEAIF 241


>gi|116284376 histone deacetylase 2 [Homo sapiens]
          Length = 582

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 58/220 (26%), Positives = 99/220 (45%), Gaps = 13/220 (5%)

Query: 27  RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86
           +P R+    + L   GL ++       +A+ EE+   HS EY+  +R  +     E    
Sbjct: 126 KPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQ 185

Query: 87  SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142
             +F+     P     F   +L+ G  +    AV     Q  +A+    G HH +++ A+
Sbjct: 186 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEAS 243

Query: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
           GFC  N++ +A     + H   R+L +D D+HHG G++  F     V+  S+H+Y  G +
Sbjct: 244 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 299

Query: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAF 242
           +P     D   +G G+G  + VN P    G+ +  Y   F
Sbjct: 300 FP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIF 336


>gi|8923769 histone deacetylase 8 [Homo sapiens]
          Length = 377

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 54/204 (26%), Positives = 96/204 (47%), Gaps = 12/204 (5%)

Query: 28  PERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALS 87
           P+R +     +    L ++   +  + AS EE+   H+  Y+  +++    G ++    S
Sbjct: 35  PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDD-HPDS 93

Query: 88  GQFDAIYFHPST---FHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANG 143
            ++   Y  P+T   F  A    GA +     ++ G  +  +A+    G HH ++  A+G
Sbjct: 94  IEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK--VAINWSGGWHHAKKDEASG 151

Query: 144 FCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFW 203
           FC  N+  +     ++K    RIL VD D+HHG G++  F     V+  S H++  G F+
Sbjct: 152 FCYLNDAVLGILRLRRK--FERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FF 208

Query: 204 PFLRESDADAVGRGQGLGFTVNLP 227
           P     D   VG G+G  ++VN+P
Sbjct: 209 P--GTGDVSDVGLGKGRYYSVNVP 230


>gi|13128862 histone deacetylase 3 [Homo sapiens]
          Length = 428

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 58/211 (27%), Positives = 94/211 (44%), Gaps = 23/211 (10%)

Query: 27  RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRE---TQVLG-KEE 82
           +P RL      +   GL ++ +     +AS+ ++   HS +Y+  ++    T + G  + 
Sbjct: 25  KPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKS 84

Query: 83  LQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNG-----LALVRPPG-HHG 136
           L A +   D   F P  F       GA LQ       GA Q       +A+    G HH 
Sbjct: 85  LNAFNVGDDCPVF-PGLFEFCSRYTGASLQ-------GATQLNNKICDIAINWAGGLHHA 136

Query: 137 QRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHR 196
           ++  A+GFC  N++ I      + H   R+L +D D+HHG G+Q  F     V+  S+H+
Sbjct: 137 KKFEASGFCYVNDIVIGILELLKYHP--RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHK 194

Query: 197 YEHGRFWPFLRESDADAVGRGQGLGFTVNLP 227
           Y  G ++ F    D   VG   G  + +N+P
Sbjct: 195 Y--GNYF-FPGTGDMYEVGAESGRYYCLNVP 222


>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
          Length = 347

 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 44/172 (25%), Positives = 78/172 (45%), Gaps = 13/172 (7%)

Query: 38  LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
           L++  L    + + AREASEE+L +VH+  Y++ ++ +  +      A   +   + F P
Sbjct: 49  LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV------ATITEIPPVIFLP 102

Query: 98  STFHCARLAAGAGLQLVDAVLTG--AVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAA 154
           +     ++      Q    ++ G  AV+ G A+    G HH       GFC + ++ +A 
Sbjct: 103 NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAI 162

Query: 155 AHAKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRF 202
               ++  G+ R  ++D D H G G +  F DD  V     ++ H Y   RF
Sbjct: 163 KFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF 214


>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%)

Query: 299 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 354
           +T    P PP + P  P  SA     +A     A       S    + TAVP +PS+ + 
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269

Query: 355 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 413
           +   P      P   AA   PS+    P   PAP   TA  +TTP+ +   L PD  +  
Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326

Query: 414 ASALREET 421
           A+   + T
Sbjct: 327 AAPTHQTT 334



 Score = 37.0 bits (84), Expect = 0.057
 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%)

Query: 340 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 399
           QD TA P +PS+ +P    PP     P   AA   PS+    P    AP   TA   T P
Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219

Query: 400 DITLVLPPDVIQQEASA 416
             T   P      E +A
Sbjct: 220 ATTPAPPSSSAPPETTA 236



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%)

Query: 300 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 359
           T    P P  + P  P  SA           AP   S   Q   +    P + +    PP
Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219

Query: 360 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 415
              P  P    ++SAP      P   P PS  T   L++   P+ T V P P     + S
Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272

Query: 416 ALREETEAWARP 427
           +     E  A P
Sbjct: 273 SASAPPETTAAP 284


>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%)

Query: 299 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 354
           +T    P PP + P  P  SA     +A     A       S    + TAVP +PS+ + 
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269

Query: 355 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 413
           +   P      P   AA   PS+    P   PAP   TA  +TTP+ +   L PD  +  
Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326

Query: 414 ASALREET 421
           A+   + T
Sbjct: 327 AAPTHQTT 334



 Score = 37.0 bits (84), Expect = 0.057
 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%)

Query: 340 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 399
           QD TA P +PS+ +P    PP     P   AA   PS+    P    AP   TA   T P
Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219

Query: 400 DITLVLPPDVIQQEASA 416
             T   P      E +A
Sbjct: 220 ATTPAPPSSSAPPETTA 236



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%)

Query: 300 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 359
           T    P P  + P  P  SA           AP   S   Q   +    P + +    PP
Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219

Query: 360 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 415
              P  P    ++SAP      P   P PS  T   L++   P+ T V P P     + S
Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272

Query: 416 ALREETEAWARP 427
           +     E  A P
Sbjct: 273 SASAPPETTAAP 284


>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
          Length = 377

 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%)

Query: 299 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 354
           +T    P PP + P  P  SA     +A     A       S    + TAVP +PS+ + 
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269

Query: 355 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 413
           +   P      P   AA   PS+    P   PAP   TA  +TTP+ +   L PD  +  
Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326

Query: 414 ASALREET 421
           A+   + T
Sbjct: 327 AAPTHQTT 334



 Score = 37.0 bits (84), Expect = 0.057
 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%)

Query: 340 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 399
           QD TA P +PS+ +P    PP     P   AA   PS+    P    AP   TA   T P
Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219

Query: 400 DITLVLPPDVIQQEASA 416
             T   P      E +A
Sbjct: 220 ATTPAPPSSSAPPETTA 236



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%)

Query: 300 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 359
           T    P P  + P  P  SA           AP   S   Q   +    P + +    PP
Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219

Query: 360 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 415
              P  P    ++SAP      P   P PS  T   L++   P+ T V P P     + S
Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272

Query: 416 ALREETEAWARP 427
           +     E  A P
Sbjct: 273 SASAPPETTAAP 284


>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
          Length = 296

 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 32/170 (18%)

Query: 38  LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
           L++  L    + + AREASEE+L +VH+  Y++ ++      ++ L+ L  Q        
Sbjct: 21  LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK------RKVLRPLRTQTGG----- 69

Query: 98  STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAAAH 156
            T    +LA               V+ G A+    G HH       GFC + ++ +A   
Sbjct: 70  -TIMAGKLA---------------VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKF 113

Query: 157 AKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRF 202
             ++  G+ R  ++D D H G G +  F DD  V     ++ H Y   RF
Sbjct: 114 LFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF 163


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 40.8 bits (94), Expect = 0.004
 Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 7/96 (7%)

Query: 305 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 359
           P+PP+  P +P  S   S  +   +QAP   +     V      + PMSPS+  P   PP
Sbjct: 669 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728

Query: 360 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVA 395
           PL    P  +   S P+S    P   P P V   +A
Sbjct: 729 PL--AAPPLQVPPSPPASPPMSPSATPPPRVPPLLA 762



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 35/119 (29%), Positives = 48/119 (40%), Gaps = 19/119 (15%)

Query: 305 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPL--- 361
           P+PP S PM+P  SA    Q+     AP  + +      + PMSPS+  P   PP L   
Sbjct: 708 PSPPASPPMSP--SATPPPQAPPPLAAPPLQ-VPPSPPASPPMSPSATPPPRVPPLLAAP 764

Query: 362 -----------LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 407
                      LP  P+ K    AP +L   P   L   P+     A  +P  +L + P
Sbjct: 765 PLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 823



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 31/108 (28%), Positives = 43/108 (39%), Gaps = 7/108 (6%)

Query: 305 PAP-PLSGPMAPCQSALESIQSARAAQAPH----WKSLQQQDVTAVPMSPSSHSPEGRPP 359
           PAP PL  P +P  +      S+ A   P       S   Q + + P+SP +  P   PP
Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPP 623

Query: 360 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 407
            L    P  +A  S P+S    P   P+P    A+A+         PP
Sbjct: 624 XL--ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 669



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%)

Query: 306 APPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGG 365
           A P  GP++    A  S    +A   P        D  A P+ P++  P    PPL    
Sbjct: 292 AAPALGPLSSSPLATPSPSGTKARPVP------PPDNAATPL-PATLPPS---PPLATPL 341

Query: 366 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITL-----VLPPDVIQQEASALREE 420
           P+   + SAP SL   P     P  +   ++TTP +        +PP  IQ   S     
Sbjct: 342 PLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPP--IQVPHSLTSPS 399

Query: 421 TEAWARPHESLAREEALTALG 441
            +A   P  +L+  +A T+LG
Sbjct: 400 LQAPPSP-LALSSLQATTSLG 419



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 31/106 (29%), Positives = 39/106 (36%), Gaps = 14/106 (13%)

Query: 311 GPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEG----RPPPLLPGGP 366
           G   P   +L S  SA    +P       +     P  PS   P+G    RPP + P   
Sbjct: 233 GLQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR- 289

Query: 367 VCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD-----ITLVLPP 407
             K AA A   L   P   P+PS   A  +  PD     +   LPP
Sbjct: 290 --KDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPP 333



 Score = 31.2 bits (69), Expect = 3.1
 Identities = 45/149 (30%), Positives = 55/149 (36%), Gaps = 35/149 (23%)

Query: 298 VQTLLGDPAPPLSGPMA--PCQSALESIQSARAAQAP----------HWKSLQQQDVTAV 345
           +QT L     PLS P+   P Q AL S+ S  + QAP             SL    +   
Sbjct: 469 LQTSLSPAVSPLSSPLTIHPLQ-ALSSLAS-HSPQAPLSSLIMPPLETQSSLAPPSLQTP 526

Query: 346 PMS----PSSHSPEGRPPPLLPGGPVCKAAASAPSS---LLDQPCLCPAPSVRTAVALTT 398
           P S    P  + P   PPPL          ASAP +   L   PC  P P       LTT
Sbjct: 527 PASLTTPPLENLPSLAPPPL--------QTASAPLTTPHLETPPCPAPCPLQAPPSPLTT 578

Query: 399 PDITLVLPPDVIQQEASALREETEAWARP 427
           P      PP+     A+   +   A A P
Sbjct: 579 P------PPETPSSIATPPPQAPPALASP 601



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 17/117 (14%)

Query: 306 APPLSGPMAPCQSALESIQSARAAQAPHWKSL---------QQQDVTAVPMSPSSHSPEG 356
           +P L  P +P   AL S+Q+  +  +P  ++          Q Q     P  P+S  P+ 
Sbjct: 397 SPSLQAPPSPL--ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDS 454

Query: 357 RP---PPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDI---TLVLPP 407
            P   P  LP  P  + + S   S L  P         +++A  +P     +L++PP
Sbjct: 455 PPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPP 511


>gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]
          Length = 1374

 Score = 40.4 bits (93), Expect = 0.005
 Identities = 34/120 (28%), Positives = 45/120 (37%), Gaps = 25/120 (20%)

Query: 303 GDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSS----------- 351
           G P  PL+G     +  LE + + RAAQ  HW+S    +  +    P S           
Sbjct: 652 GAPPLPLTG-----EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAE 706

Query: 352 ------HSPEGRPPPLLPGGPVC---KAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT 402
                  +P   P P  PG P+     A+A  P      P LC A  +  A  L TP  T
Sbjct: 707 GCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWT 766


>gi|239754940 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 159

 Score = 40.0 bits (92), Expect = 0.007
 Identities = 35/108 (32%), Positives = 44/108 (40%), Gaps = 21/108 (19%)

Query: 305 PAPPLSGPMAPCQSALESIQSARAAQAPHWKS------------------LQQQDVTAVP 346
           PAP  + P AP +    +  SA AA  P  +S                  LQ +   AVP
Sbjct: 50  PAPAAAHPPAPRERPAAARLSALAAAQPRRRSPGPQGGGGGDIASPLPPALQPRGAPAVP 109

Query: 347 MSPSSHSPEGRP---PPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVR 391
            +PS      RP   PP  P  PV  A +S P+    Q    PAPS+R
Sbjct: 110 AAPSPGPLPARPSSPPPSPPSPPVPTAQSSLPAPWPPQGPRSPAPSLR 157


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 38.9 bits (89), Expect = 0.015
 Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 8/111 (7%)

Query: 305 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 359
           P+PP+  P +P  S   S  +   +QAP   +     V      + PMSPS+  P   PP
Sbjct: 444 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 503

Query: 360 PL-LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 407
           PL  P   + K    AP +L   P   L   P+     A  +P  +L + P
Sbjct: 504 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 554



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 28/96 (29%), Positives = 37/96 (38%), Gaps = 13/96 (13%)

Query: 306 APPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGG 365
           A P  GP++    A  S  +A  +QAP         + A P S S       P PL P  
Sbjct: 292 AAPALGPLSSSPLATPSPSAALQSQAP-------PTLPATPHSSSLTCQLATPLPLAPPS 344

Query: 366 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDI 401
           P      SAP SL   P     P  +   +L +P +
Sbjct: 345 P------SAPPSLQTLPSPPATPPSQATTSLGSPTL 374


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 38.9 bits (89), Expect = 0.015
 Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 8/111 (7%)

Query: 305 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 359
           P+PP+  P +P  S   S  +   +QAP   +     V      + PMSPS+  P   PP
Sbjct: 405 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464

Query: 360 PL-LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 407
           PL  P   + K    AP +L   P   L   P+     A  +P  +L + P
Sbjct: 465 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 515



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 30/109 (27%), Positives = 40/109 (36%), Gaps = 9/109 (8%)

Query: 311 GPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEG----RPPPLLPGGP 366
           G   P   +L S  SA    +P       +     P  PS   P+G    RPP + P   
Sbjct: 224 GLQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR- 280

Query: 367 VCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEAS 415
             K AA A   L   P   P+PS   + +      TL  PP     +A+
Sbjct: 281 --KDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
            sapiens]
          Length = 1560

 Score = 38.9 bits (89), Expect = 0.015
 Identities = 44/174 (25%), Positives = 61/174 (35%), Gaps = 13/174 (7%)

Query: 304  DPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLP 363
            +PAP   GP  P               APH          A     SS  P   P     
Sbjct: 849  NPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQL 908

Query: 364  GGPVCKAAASAPSS-----LLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQ---QEAS 415
              P  +    +P+      L+ +P   P P  RT   +TTP   L  P  +++   Q  S
Sbjct: 909  QFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPS 968

Query: 416  ALREETEAWARPHESLAREEALTALGKLLYLLDGML-DGQVNSGIAATPASAAA 468
             +  + +A   P    A  +  T+LG L      +L  GQ  SG    P+ A A
Sbjct: 969  GIILQNKAGGAP----AAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPA 1018


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 10/114 (8%)

Query: 286 HLESLAESVCMTVQ---TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV 342
           HL  + E +C+  Q    L GD AP  S P    ++A  +  SA +  +P  +    +  
Sbjct: 628 HLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK- 686

Query: 343 TAVPMSPSSHSPE-GRPPPL-----LPGGPVCKAAASAPSSLLDQPCLCPAPSV 390
            A P    S +PE  +PPPL     L G P  KA     +  L +P     PSV
Sbjct: 687 DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 38.5 bits (88), Expect = 0.020
 Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 10/114 (8%)

Query: 286 HLESLAESVCMTVQ---TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV 342
           HL  + E +C+  Q    L GD AP  S P    ++A  +  SA +  +P  +    +  
Sbjct: 628 HLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK- 686

Query: 343 TAVPMSPSSHSPE-GRPPPL-----LPGGPVCKAAASAPSSLLDQPCLCPAPSV 390
            A P    S +PE  +PPPL     L G P  KA     +  L +P     PSV
Sbjct: 687 DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 36.6 bits (83), Expect = 0.074
 Identities = 26/103 (25%), Positives = 39/103 (37%), Gaps = 4/103 (3%)

Query: 305  PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPG 364
            P+PP + P+ P  S      +   +  P   +      T  P  P++ +P   PP +   
Sbjct: 1539 PSPPTTTPITPPTSTTTLPPTTTPSPPP--TTTTTPPPTTTPSPPTTTTPS--PPTITTT 1594

Query: 365  GPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 407
             P      S P++    P     PS  T   +T P  T  LPP
Sbjct: 1595 TPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP 1637



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 27/118 (22%), Positives = 39/118 (33%), Gaps = 8/118 (6%)

Query: 295  CMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSP 354
            C  +   +  P+PP + P  P  S   +        +P   +      T  P SP   + 
Sbjct: 1389 CWPMDKCITTPSPPTTTPSPPPTST--TTLPPTTTPSPPTTTTTTPPPTTTP-SPPITTT 1445

Query: 355  EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPA-----PSVRTAVALTTPDITLVLPP 407
               PP   P  P+       P++    P   P+     PS  T    T P  T   PP
Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPP 1503



 Score = 30.4 bits (67), Expect = 5.3
 Identities = 24/108 (22%), Positives = 37/108 (34%), Gaps = 6/108 (5%)

Query: 305  PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPE-----GRPP 359
            P+PP + P+ P  S      +   +  P   +      T  P + ++ SP        PP
Sbjct: 1618 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPP 1677

Query: 360  PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 407
               P  P+     S P++ +  P     PS       T    T   PP
Sbjct: 1678 TTTPSSPIT-TTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPP 1724


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,040,171
Number of Sequences: 37866
Number of extensions: 1407685
Number of successful extensions: 6233
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 5924
Number of HSP's gapped (non-prelim): 392
length of query: 649
length of database: 18,247,518
effective HSP length: 109
effective length of query: 540
effective length of database: 14,120,124
effective search space: 7624866960
effective search space used: 7624866960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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