Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 11545920
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11545920 lin-7 homolog B [Homo sapiens]
(207 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11545920 lin-7 homolog B [Homo sapiens] 401 e-112
gi|8922944 lin-7 homolog C [Homo sapiens] 337 4e-93
gi|4759306 lin-7 homolog A [Homo sapiens] 315 2e-86
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 89 3e-18
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 89 3e-18
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 88 4e-18
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 84 1e-16
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 84 1e-16
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 80 2e-15
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 80 2e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 78 5e-15
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 78 5e-15
gi|9966877 golgi associated PDZ and coiled-coil motif containing... 74 9e-14
gi|62868213 golgi associated PDZ and coiled-coil motif containin... 74 9e-14
gi|148746189 multiple PDZ domain protein [Homo sapiens] 73 1e-13
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 70 1e-12
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 70 1e-12
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 70 1e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 69 3e-12
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 69 3e-12
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 69 3e-12
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 69 3e-12
gi|31742501 sorting nexin family member 27 [Homo sapiens] 69 4e-12
gi|112382257 InaD-like [Homo sapiens] 67 8e-12
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 67 1e-11
gi|7706025 PDZ domain containing 11 [Homo sapiens] 67 1e-11
gi|5803177 basic beta 2 syntrophin [Homo sapiens] 67 1e-11
gi|45827729 scribble isoform b [Homo sapiens] 65 4e-11
gi|45827731 scribble isoform a [Homo sapiens] 65 4e-11
gi|13376349 PDZ domain containing 7 [Homo sapiens] 65 5e-11
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 401 bits (1030), Expect = e-112
Identities = 207/207 (100%), Positives = 207/207 (100%)
Query: 1 MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT 60
MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT
Sbjct: 1 MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT 60
Query: 61 LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS 120
LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS
Sbjct: 61 LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS 120
Query: 121 RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE 180
RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE
Sbjct: 121 RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE 180
Query: 181 MEARFEKMRSARRRQQHQSYSSLESRG 207
MEARFEKMRSARRRQQHQSYSSLESRG
Sbjct: 181 MEARFEKMRSARRRQQHQSYSSLESRG 207
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 337 bits (864), Expect = 4e-93
Identities = 166/196 (84%), Positives = 186/196 (94%)
Query: 1 MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT 60
MAAL EP+ LERD+ RA+ELLE+LQRSGE+PPQKLQALQRVLQS FC+A+REVYE +Y+T
Sbjct: 1 MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET 60
Query: 61 LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS 120
+DI+ S E+RA+ATAKATVAAF ASEGH+HPRVVELPKT+EGLGFNIMGGKEQNSPIYIS
Sbjct: 61 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS 120
Query: 121 RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE 180
R+IPGG+ADRHGGLKRGDQLLSVNGVSVEGE HEKAVELLKAAQG VKLVVRYTP+VLEE
Sbjct: 121 RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE 180
Query: 181 MEARFEKMRSARRRQQ 196
ME+RFEKMRSA+RRQQ
Sbjct: 181 MESRFEKMRSAKRRQQ 196
>gi|4759306 lin-7 homolog A [Homo sapiens]
Length = 233
Score = 315 bits (806), Expect = 2e-86
Identities = 154/195 (78%), Positives = 179/195 (91%)
Query: 4 LVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLDI 63
+V+PL L+RDV+RA+ELLE+LQ SGE+P KLQ+L++VLQS FC+AIREVY+ +++T+ +
Sbjct: 19 VVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITV 78
Query: 64 TGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVI 123
G E RA ATAKATVAAF ASEGH+HPRVVELPKTDEGLGFN+MGGKEQNSPIYISR+I
Sbjct: 79 NGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRII 138
Query: 124 PGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEA 183
PGGVA+RHGGLKRGDQLLSVNGVSVEGE HEKAVELLKAA+ SVKLVVRYTP+VLEEMEA
Sbjct: 139 PGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEA 198
Query: 184 RFEKMRSARRRQQHQ 198
RFEK+R+ARRRQQ Q
Sbjct: 199 RFEKLRTARRRQQQQ 213
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 88.6 bits (218), Expect = 3e-18
Identities = 57/148 (38%), Positives = 81/148 (54%), Gaps = 11/148 (7%)
Query: 61 LDITGSAEIRAH-----ATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNS 115
L + +E+ +H AT + ++ A PR V L K GLGFNI+GG E
Sbjct: 489 LGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGE 547
Query: 116 PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTP 175
I++S ++ GG AD G L+RGDQ+LSVNG+ + G HE+A LK A +V ++ +Y P
Sbjct: 548 GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 607
Query: 176 RVLEEMEARFE-KMRSARRRQQHQSYSS 202
E ARFE K+ R + + S SS
Sbjct: 608 ----EDYARFEAKIHDLREQMMNHSMSS 631
Score = 62.8 bits (151), Expect = 2e-10
Identities = 37/91 (40%), Positives = 51/91 (56%), Gaps = 5/91 (5%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
+ L + + GLGF+I GG + + I+I+++IPGG A G L+ D +L VN V V
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 149 EGEQHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H KAVE LK A V+L VR +LE
Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 294
Score = 60.5 bits (145), Expect = 1e-09
Identities = 43/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D +++ S + A A + V + VVE+ K +GLGF+I GG Q+
Sbjct: 262 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI 321
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD+LL VN S+E HE+AV +LK V L V
Sbjct: 322 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 88.6 bits (218), Expect = 3e-18
Identities = 57/148 (38%), Positives = 81/148 (54%), Gaps = 11/148 (7%)
Query: 61 LDITGSAEIRAH-----ATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNS 115
L + +E+ +H AT + ++ A PR V L K GLGFNI+GG E
Sbjct: 384 LGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGE 442
Query: 116 PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTP 175
I++S ++ GG AD G L+RGDQ+LSVNG+ + G HE+A LK A +V ++ +Y P
Sbjct: 443 GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502
Query: 176 RVLEEMEARFE-KMRSARRRQQHQSYSS 202
E ARFE K+ R + + S SS
Sbjct: 503 ----EDYARFEAKIHDLREQMMNHSMSS 526
Score = 62.8 bits (151), Expect = 2e-10
Identities = 37/91 (40%), Positives = 51/91 (56%), Gaps = 5/91 (5%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
+ L + + GLGF+I GG + + I+I+++IPGG A G L+ D +L VN V V
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 149 EGEQHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H KAVE LK A V+L VR +LE
Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 189
Score = 60.5 bits (145), Expect = 1e-09
Identities = 43/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D +++ S + A A + V + VVE+ K +GLGF+I GG Q+
Sbjct: 157 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI 216
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD+LL VN S+E HE+AV +LK V L V
Sbjct: 217 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 88.2 bits (217), Expect = 4e-18
Identities = 54/131 (41%), Positives = 74/131 (56%), Gaps = 6/131 (4%)
Query: 73 ATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHG 132
AT + ++ A PR V L K GLGFNI+GG E I++S ++ GG AD G
Sbjct: 298 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSG 356
Query: 133 GLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFE-KMRSA 191
L+RGDQ+LSVNG+ + G HE+A LK A +V ++ +Y P E ARFE K+
Sbjct: 357 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP----EDYARFEAKIHDL 412
Query: 192 RRRQQHQSYSS 202
R + + S SS
Sbjct: 413 REQMMNHSMSS 423
Score = 62.8 bits (151), Expect = 2e-10
Identities = 37/91 (40%), Positives = 51/91 (56%), Gaps = 5/91 (5%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
+ L + + GLGF+I GG + + I+I+++IPGG A G L+ D +L VN V V
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 149 EGEQHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H KAVE LK A V+L VR +LE
Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 138
Score = 60.5 bits (145), Expect = 1e-09
Identities = 43/120 (35%), Positives = 63/120 (52%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D +++ S + A A + V + VVE+ K +GLGF+I GG Q+
Sbjct: 106 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHI 165
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD+LL VN S+E HE+AV +LK V L V
Sbjct: 166 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 83.6 bits (205), Expect = 1e-16
Identities = 50/113 (44%), Positives = 68/113 (60%), Gaps = 6/113 (5%)
Query: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
PR + L K GLGFNI+GG E I++S ++ GG AD G L+RGD++LSVNGV++
Sbjct: 47 PRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105
Query: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFE-KMRSARRRQQHQSYSS 202
HE+A LK A SV +V +Y P E +RFE K+ R + + S SS
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRP----EEYSRFESKIHDLREQMMNSSMSS 154
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 83.6 bits (205), Expect = 1e-16
Identities = 50/113 (44%), Positives = 68/113 (60%), Gaps = 6/113 (5%)
Query: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
PR + L K GLGFNI+GG E I++S ++ GG AD G L+RGD++LSVNGV++
Sbjct: 384 PRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 442
Query: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFE-KMRSARRRQQHQSYSS 202
HE+A LK A SV +V +Y P E +RFE K+ R + + S SS
Sbjct: 443 ATHEQAAAALKRAGQSVTIVAQYRP----EEYSRFESKIHDLREQMMNSSMSS 491
Score = 58.9 bits (141), Expect = 3e-09
Identities = 36/83 (43%), Positives = 51/83 (61%), Gaps = 5/83 (6%)
Query: 94 VELPKTDEGLGFNIMGG-KEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
V L K +GLGF+I GG Q+ P IYI+++I GG A + G L+ GD+LL+VN ++
Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286
Query: 149 EGEQHEKAVELLKAAQGSVKLVV 171
+ +HE+AV LK V L V
Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKV 309
Score = 57.4 bits (137), Expect = 8e-09
Identities = 37/93 (39%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 85 SEGHAHPRVVELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQ 139
S+G + L + + GLGF+I GG + + I+I+++IPGG A G L D
Sbjct: 123 SDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDC 182
Query: 140 LLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVR 172
+L VN V V H +AVE LK A V+LVVR
Sbjct: 183 VLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVR 215
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 79.7 bits (195), Expect = 2e-15
Identities = 41/99 (41%), Positives = 59/99 (59%), Gaps = 1/99 (1%)
Query: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
PR + + + GLGFNI+GG E I+IS ++ GG AD G L++GDQ+LSVNGV +
Sbjct: 354 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 412
Query: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMR 189
HE+A LK A +V ++ +Y P EA+ +R
Sbjct: 413 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLR 451
Score = 63.2 bits (152), Expect = 2e-10
Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D ++T SA + A A + V + +V+E+ K +GLGF+I GG Q+
Sbjct: 167 DVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI 226
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD++L+VN V +E HE AV LK V L V
Sbjct: 227 PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286
Score = 62.4 bits (150), Expect = 3e-10
Identities = 40/109 (36%), Positives = 58/109 (53%), Gaps = 6/109 (5%)
Query: 85 SEGHAHPRVVELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQ 139
+EG + L + + GLGF+I GG + + I+I+++IPGG A + G L+ D
Sbjct: 100 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 159
Query: 140 LLSVNGVSVEGEQHEKAVELLKAAQGSVKL-VVRYTPRVLEEMEARFEK 187
+L VN V V H AVE LK A V+L V+R P + ME + K
Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 208
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 79.7 bits (195), Expect = 2e-15
Identities = 41/99 (41%), Positives = 59/99 (59%), Gaps = 1/99 (1%)
Query: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
PR + + + GLGFNI+GG E I+IS ++ GG AD G L++GDQ+LSVNGV +
Sbjct: 308 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 366
Query: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMR 189
HE+A LK A +V ++ +Y P EA+ +R
Sbjct: 367 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLR 405
Score = 63.2 bits (152), Expect = 2e-10
Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D ++T SA + A A + V + +V+E+ K +GLGF+I GG Q+
Sbjct: 121 DVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI 180
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD++L+VN V +E HE AV LK V L V
Sbjct: 181 PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
Score = 62.4 bits (150), Expect = 3e-10
Identities = 40/109 (36%), Positives = 58/109 (53%), Gaps = 6/109 (5%)
Query: 85 SEGHAHPRVVELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQ 139
+EG + L + + GLGF+I GG + + I+I+++IPGG A + G L+ D
Sbjct: 54 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 113
Query: 140 LLSVNGVSVEGEQHEKAVELLKAAQGSVKL-VVRYTPRVLEEMEARFEK 187
+L VN V V H AVE LK A V+L V+R P + ME + K
Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 162
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 78.2 bits (191), Expect = 5e-15
Identities = 45/112 (40%), Positives = 63/112 (56%), Gaps = 4/112 (3%)
Query: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
PR V L + GLGFNI+GG E I+IS ++ GG AD G L++GD+++SVN V +
Sbjct: 464 PRKVVLHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522
Query: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSS 202
HE+A LK A +V +V +Y P EA K+ R + + S SS
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEA---KIHDLREQMMNSSISS 571
Score = 63.9 bits (154), Expect = 9e-11
Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D D+T S + A A + V + +++E+ K +GLGF+I GG Q+
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHI 342
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD+LL+VN V +E HE+AV LK V L V
Sbjct: 343 PGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 60.5 bits (145), Expect = 1e-09
Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 5/93 (5%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
+ L + + GLGF+I GG + +S I+I+++I GG A + G L+ D +L VN V V
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 149 EGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEM 181
H KAVE LK A V+L V+ V E++
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI 317
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 78.2 bits (191), Expect = 5e-15
Identities = 45/112 (40%), Positives = 63/112 (56%), Gaps = 4/112 (3%)
Query: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
PR V L + GLGFNI+GG E I+IS ++ GG AD G L++GD+++SVN V +
Sbjct: 464 PRKVVLHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522
Query: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSS 202
HE+A LK A +V +V +Y P EA K+ R + + S SS
Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEA---KIHDLREQMMNSSISS 571
Score = 63.9 bits (154), Expect = 9e-11
Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 7/120 (5%)
Query: 59 DTLDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELP--KTDEGLGFNIMGGK-EQNS 115
D D+T S + A A + V + +++E+ K +GLGF+I GG Q+
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHI 342
Query: 116 P----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
P IY++++I GG A + G L+ GD+LL+VN V +E HE+AV LK V L V
Sbjct: 343 PGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 60.5 bits (145), Expect = 1e-09
Identities = 36/93 (38%), Positives = 53/93 (56%), Gaps = 5/93 (5%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-----NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSV 148
+ L + + GLGF+I GG + +S I+I+++I GG A + G L+ D +L VN V V
Sbjct: 225 ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284
Query: 149 EGEQHEKAVELLKAAQGSVKLVVRYTPRVLEEM 181
H KAVE LK A V+L V+ V E++
Sbjct: 285 RDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKI 317
>gi|9966877 golgi associated PDZ and coiled-coil motif containing
isoform a [Homo sapiens]
Length = 462
Score = 73.9 bits (180), Expect = 9e-14
Identities = 42/90 (46%), Positives = 56/90 (62%), Gaps = 1/90 (1%)
Query: 85 SEGHAHPRVVELPKTD-EGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSV 143
S+G R V L K D EGLG +I GGKE PI IS + PG ADR GGL GD +L+V
Sbjct: 280 SQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAV 339
Query: 144 NGVSVEGEQHEKAVELLKAAQGSVKLVVRY 173
NGV++ +H++AV +L +G ++ V Y
Sbjct: 340 NGVNLRDTKHKEAVTILSQQRGEIEFEVVY 369
>gi|62868213 golgi associated PDZ and coiled-coil motif containing
isoform b [Homo sapiens]
Length = 454
Score = 73.9 bits (180), Expect = 9e-14
Identities = 42/90 (46%), Positives = 56/90 (62%), Gaps = 1/90 (1%)
Query: 85 SEGHAHPRVVELPKTD-EGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSV 143
S+G R V L K D EGLG +I GGKE PI IS + PG ADR GGL GD +L+V
Sbjct: 272 SQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAV 331
Query: 144 NGVSVEGEQHEKAVELLKAAQGSVKLVVRY 173
NGV++ +H++AV +L +G ++ V Y
Sbjct: 332 NGVNLRDTKHKEAVTILSQQRGEIEFEVVY 361
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 73.2 bits (178), Expect = 1e-13
Identities = 40/101 (39%), Positives = 59/101 (58%), Gaps = 3/101 (2%)
Query: 74 TAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGG---KEQNSPIYISRVIPGGVADR 130
T + + F G + + L + +GLGF+I+GG + PIY+ V G A
Sbjct: 1939 TGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998
Query: 131 HGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
G LKRGDQ+++VNG S+EG HE+AV +LK +G+V L+V
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 65.1 bits (157), Expect = 4e-11
Identities = 32/98 (32%), Positives = 53/98 (54%), Gaps = 2/98 (2%)
Query: 74 TAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGG 133
+A +T++A + H +EL GLGF I+GGK + + ++PGGVAD+HG
Sbjct: 238 SAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATG--VIVKTILPGGVADQHGR 295
Query: 134 LKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
L GD +L + + G E+ ++L+ VKL++
Sbjct: 296 LCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Score = 59.3 bits (142), Expect = 2e-09
Identities = 34/83 (40%), Positives = 53/83 (63%), Gaps = 5/83 (6%)
Query: 94 VELPKTDEGLGFNIMGGKEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
+EL K +GLGF+I+ ++ P I I ++PGG+A++ G L GD+L+ VN V++E
Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760
Query: 150 GEQHEKAVELLKAA-QGSVKLVV 171
E+AVE LK A G+V++ V
Sbjct: 761 NSSLEEAVEALKGAPSGTVRIGV 783
Score = 58.5 bits (140), Expect = 4e-09
Identities = 28/70 (40%), Positives = 44/70 (62%), Gaps = 1/70 (1%)
Query: 98 KTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157
K +GLG +I+G K ++ +++S ++ GG+AD G L +GDQ+L VNG V E
Sbjct: 1731 KPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVA 1789
Query: 158 ELLKAAQGSV 167
LLK ++GS+
Sbjct: 1790 ALLKVSEGSL 1799
Score = 55.5 bits (132), Expect = 3e-08
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 1/79 (1%)
Query: 93 VVELPKTDEGLGFNIMGGKEQNS-PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
++EL K GLG ++ G K+++ ++I + P G A + G L+ D+LL +NG + G
Sbjct: 1350 MIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409
Query: 152 QHEKAVELLKAAQGSVKLV 170
H+ A ++K A VK++
Sbjct: 1410 SHQNASSIIKCAPSKVKII 1428
Score = 54.7 bits (130), Expect = 5e-08
Identities = 33/84 (39%), Positives = 51/84 (60%), Gaps = 4/84 (4%)
Query: 92 RVVELPK-TDEGLGFNIMGGKEQ---NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
R VE+ K + LG +I GG + PI+I+ + P GVA + L+ GD+++++ G S
Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV 171
EG H +AV LLK A GS+++ V
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQV 1915
Score = 54.3 bits (129), Expect = 7e-08
Identities = 31/87 (35%), Positives = 54/87 (62%), Gaps = 5/87 (5%)
Query: 90 HPRVVELPKTDEG-LGFNIMGGKEQNSP---IYISRVIPGGVADRHGGLKRGDQLLSVNG 145
H V EL K G LGF+++G + +N I++ + G VA R G LK DQ+L++NG
Sbjct: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
Query: 146 VSVEGE-QHEKAVELLKAAQGSVKLVV 171
+++ H++A+ +L+ A+ +V+LV+
Sbjct: 194 QALDQTITHQQAISILQKAKDTVQLVI 220
Score = 50.8 bits (120), Expect = 8e-07
Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 7/105 (6%)
Query: 74 TAKATVAAFTASEGHAHPRV------VELPKTDEGLGFNIMGGKEQN-SPIYISRVIPGG 126
T++++ A AS+ P + +E+ K GLG +I+GG + I I V G
Sbjct: 1604 TSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEG 1663
Query: 127 VADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
A + G L GDQ+L VNG+ + H++A+ +L+ V+L +
Sbjct: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL 1708
Score = 49.7 bits (117), Expect = 2e-06
Identities = 32/100 (32%), Positives = 52/100 (52%), Gaps = 10/100 (10%)
Query: 83 TASEGHAHPRVVEL-PKTDEGLGFNIMGGKEQNSP---------IYISRVIPGGVADRHG 132
TA PR VEL + + LG +I+GG+ S I+I V+ A ++G
Sbjct: 1141 TAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNG 1200
Query: 133 GLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVR 172
LK GD+++ V+G+ + HE+AVE ++ A V +V+
Sbjct: 1201 TLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
Score = 48.9 bits (115), Expect = 3e-06
Identities = 32/78 (41%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Query: 94 VELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQH 153
+ELPK GLG I ++ S + I + GVA G LK GDQ+L+V+ V G
Sbjct: 1484 LELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
Query: 154 EKAVELLKAAQGSVKLVV 171
EK + LLK A+ +VKL +
Sbjct: 1543 EKFISLLKTAKMTVKLTI 1560
Score = 47.0 bits (110), Expect = 1e-05
Identities = 29/103 (28%), Positives = 54/103 (52%), Gaps = 4/103 (3%)
Query: 73 ATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMG----GKEQNSPIYISRVIPGGVA 128
+T + V A T + VEL K +GLG I G K + S I++ +
Sbjct: 357 STPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAV 416
Query: 129 DRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVV 171
+ G ++ GDQ+++V+G +++G +++AVE+L+ +V L +
Sbjct: 417 EHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTL 459
Score = 42.7 bits (99), Expect = 2e-04
Identities = 21/53 (39%), Positives = 30/53 (56%)
Query: 118 YISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLV 170
+I V+P G G L GD+LL VNG+++ GE H+ V +LK V +V
Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 32.0 bits (71), Expect = 0.38
Identities = 19/70 (27%), Positives = 33/70 (47%), Gaps = 1/70 (1%)
Query: 92 RVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
R + + K + LG + K+ I + +I GG R G + GD +LS+N S
Sbjct: 1007 RTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSINEESTISV 1065
Query: 152 QHEKAVELLK 161
+ +A +L+
Sbjct: 1066 TNAQARAMLR 1075
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 70.5 bits (171), Expect = 1e-12
Identities = 34/77 (44%), Positives = 48/77 (62%), Gaps = 2/77 (2%)
Query: 98 KTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157
+ + G GF I+GG E PIYI ++P G AD G L+ GD+L+ V+G V G+ H+ V
Sbjct: 846 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 905
Query: 158 ELLK--AAQGSVKLVVR 172
+L++ A QG V L VR
Sbjct: 906 QLMQQAAKQGHVNLTVR 922
Score = 64.3 bits (155), Expect = 7e-11
Identities = 28/79 (35%), Positives = 51/79 (64%)
Query: 94 VELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQH 153
VEL + +G GF++ GG+E N +Y+ R+ G A+R G ++ GD++L +NG + + +H
Sbjct: 1153 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1212
Query: 154 EKAVELLKAAQGSVKLVVR 172
+A+EL+K V+L ++
Sbjct: 1213 SRAIELIKNGGRRVRLFLK 1231
Score = 48.9 bits (115), Expect = 3e-06
Identities = 25/54 (46%), Positives = 33/54 (61%)
Query: 116 PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL 169
P I R+I G ADR G LK GD++L+VNG S+ + H V L+K A +V L
Sbjct: 1035 PHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1088
Score = 44.7 bits (104), Expect = 6e-05
Identities = 21/68 (30%), Positives = 38/68 (55%)
Query: 95 ELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHE 154
+L K+ G GF ++GG E + + I ++ G A G ++ GD ++SVN V G H
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 155 KAVELLKA 162
+ V++ ++
Sbjct: 534 QVVKIFQS 541
Score = 29.3 bits (64), Expect = 2.5
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 14/140 (10%)
Query: 71 AHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIM---GGKEQNSPIYISRVIPGGV 127
+H TV+ ++ V + K G GF I GG Q + +++
Sbjct: 621 SHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQR----VKQIVD--- 673
Query: 128 ADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELL-KAAQGS-VKLVVRYTPRVLEEMEARF 185
+ R GLK GD ++ VN +V+ H + V++L + +GS V L+V+ + + +
Sbjct: 674 SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKS 733
Query: 186 EKMRSARRRQQHQSYSSLES 205
+ + R+ Q+ S S+ S
Sbjct: 734 QPLE--RKDSQNSSQHSVSS 751
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 70.5 bits (171), Expect = 1e-12
Identities = 34/77 (44%), Positives = 48/77 (62%), Gaps = 2/77 (2%)
Query: 98 KTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157
+ + G GF I+GG E PIYI ++P G AD G L+ GD+L+ V+G V G+ H+ V
Sbjct: 818 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 877
Query: 158 ELLK--AAQGSVKLVVR 172
+L++ A QG V L VR
Sbjct: 878 QLMQQAAKQGHVNLTVR 894
Score = 65.1 bits (157), Expect = 4e-11
Identities = 35/121 (28%), Positives = 65/121 (53%), Gaps = 12/121 (9%)
Query: 94 VELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQH 153
VEL + +G GF++ GG+E N +Y+ R+ G A+R G ++ GD++L +NG + + +H
Sbjct: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
Query: 154 EKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEK------------MRSARRRQQHQSYS 201
+A+EL+K V+L ++ + E + ++ +R+ R+QH S
Sbjct: 1184 SRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLE 1243
Query: 202 S 202
S
Sbjct: 1244 S 1244
Score = 48.9 bits (115), Expect = 3e-06
Identities = 25/54 (46%), Positives = 33/54 (61%)
Query: 116 PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL 169
P I R+I G ADR G LK GD++L+VNG S+ + H V L+K A +V L
Sbjct: 1006 PHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1059
Score = 44.7 bits (104), Expect = 6e-05
Identities = 21/68 (30%), Positives = 38/68 (55%)
Query: 95 ELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHE 154
+L K+ G GF ++GG E + + I ++ G A G ++ GD ++SVN V G H
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 155 KAVELLKA 162
+ V++ ++
Sbjct: 534 QVVKIFQS 541
Score = 29.3 bits (64), Expect = 2.5
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 14/140 (10%)
Query: 71 AHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIM---GGKEQNSPIYISRVIPGGV 127
+H TV+ ++ V + K G GF I GG Q + +++
Sbjct: 621 SHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQR----VKQIVD--- 673
Query: 128 ADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELL-KAAQGS-VKLVVRYTPRVLEEMEARF 185
+ R GLK GD ++ VN +V+ H + V++L + +GS V L+V+ + + +
Sbjct: 674 SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKS 733
Query: 186 EKMRSARRRQQHQSYSSLES 205
+ + R+ Q+ S S+ S
Sbjct: 734 QPLE--RKDSQNSSQHSVSS 751
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 70.5 bits (171), Expect = 1e-12
Identities = 34/77 (44%), Positives = 48/77 (62%), Gaps = 2/77 (2%)
Query: 98 KTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157
+ + G GF I+GG E PIYI ++P G AD G L+ GD+L+ V+G V G+ H+ V
Sbjct: 846 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 905
Query: 158 ELLK--AAQGSVKLVVR 172
+L++ A QG V L VR
Sbjct: 906 QLMQQAAKQGHVNLTVR 922
Score = 64.3 bits (155), Expect = 7e-11
Identities = 28/79 (35%), Positives = 51/79 (64%)
Query: 94 VELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQH 153
VEL + +G GF++ GG+E N +Y+ R+ G A+R G ++ GD++L +NG + + +H
Sbjct: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
Query: 154 EKAVELLKAAQGSVKLVVR 172
+A+EL+K V+L ++
Sbjct: 1212 SRAIELIKNGGRRVRLFLK 1230
Score = 48.9 bits (115), Expect = 3e-06
Identities = 25/54 (46%), Positives = 33/54 (61%)
Query: 116 PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKL 169
P I R+I G ADR G LK GD++L+VNG S+ + H V L+K A +V L
Sbjct: 1034 PHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1087
Score = 44.7 bits (104), Expect = 6e-05
Identities = 21/68 (30%), Positives = 38/68 (55%)
Query: 95 ELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHE 154
+L K+ G GF ++GG E + + I ++ G A G ++ GD ++SVN V G H
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 155 KAVELLKA 162
+ V++ ++
Sbjct: 534 QVVKIFQS 541
Score = 29.3 bits (64), Expect = 2.5
Identities = 34/140 (24%), Positives = 63/140 (45%), Gaps = 14/140 (10%)
Query: 71 AHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIM---GGKEQNSPIYISRVIPGGV 127
+H TV+ ++ V + K G GF I GG Q + +++
Sbjct: 621 SHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQR----VKQIVD--- 673
Query: 128 ADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELL-KAAQGS-VKLVVRYTPRVLEEMEARF 185
+ R GLK GD ++ VN +V+ H + V++L + +GS V L+V+ + + +
Sbjct: 674 SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKS 733
Query: 186 EKMRSARRRQQHQSYSSLES 205
+ + R+ Q+ S S+ S
Sbjct: 734 QPLE--RKDSQNSSQHSVSS 751
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 68.9 bits (167), Expect = 3e-12
Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 7/111 (6%)
Query: 102 GLGFNIMGGKEQNS---PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVE 158
GLGF I+GG++ I+IS V PGG AD G LK GD+L+SVN VS+EG H A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 159 LLKAAQGSVKLVVRYTPRVLEEMEAR----FEKMRSARRRQQHQSYSSLES 205
+L+ A V LV+ + ++ + +M++ ++ + S+++S
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDS 1213
Score = 58.9 bits (141), Expect = 3e-09
Identities = 34/86 (39%), Positives = 51/86 (59%), Gaps = 8/86 (9%)
Query: 94 VELPKTDEGLGFNIM-----GGKE---QNSPIYISRVIPGGVADRHGGLKRGDQLLSVNG 145
VEL K D LG ++ GG ++ IY+ VIP G A+ G + +GD++L+VNG
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428
Query: 146 VSVEGEQHEKAVELLKAAQGSVKLVV 171
VS+EG H++AVE L+ V L++
Sbjct: 1429 VSLEGATHKQAVETLRNTGQVVHLLL 1454
Score = 45.4 bits (106), Expect = 3e-05
Identities = 35/88 (39%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 93 VVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
++ L K+++G LGF + G Q Y+ VI A G LK GD+L+ VN V
Sbjct: 1793 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1850
Query: 152 QHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H AV LL+AA +V+LV+ RVLE
Sbjct: 1851 THTDAVNLLRAASKTVRLVI---GRVLE 1875
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 94 VELPKTDEGLGF------NIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S
Sbjct: 1507 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV-RYTPRVLEEME 182
++G ++ + L+ V L++ R P VL E++
Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1602
Score = 37.0 bits (84), Expect = 0.012
Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 10/87 (11%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG-- 150
+ L E LGF++ GG + +YIS + P VA G L+ D + VNGVS +G
Sbjct: 1889 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1948
Query: 151 -EQHEKAVEL------LKAAQGSVKLV 170
E+ +A+++ LKA + + +V
Sbjct: 1949 LEEVNRALDMSLPSLVLKATRNDLPVV 1975
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 68.9 bits (167), Expect = 3e-12
Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 7/111 (6%)
Query: 102 GLGFNIMGGKEQNS---PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVE 158
GLGF I+GG++ I+IS V PGG AD G LK GD+L+SVN VS+EG H A+E
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 159 LLKAAQGSVKLVVRYTPRVLEEMEAR----FEKMRSARRRQQHQSYSSLES 205
+L+ A V LV+ + ++ + +M++ ++ + S+++S
Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDS 1022
Score = 65.1 bits (157), Expect = 4e-11
Identities = 34/81 (41%), Positives = 51/81 (62%), Gaps = 3/81 (3%)
Query: 94 VELPKTDEGLGFNIMGGKE---QNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
VEL K D LG ++ GG ++ IY+ VIP G A+ G + +GD++L+VNGVS+EG
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237
Query: 151 EQHEKAVELLKAAQGSVKLVV 171
H++AVE L+ V L++
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLL 1258
Score = 45.4 bits (106), Expect = 3e-05
Identities = 35/88 (39%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 93 VVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
++ L K+++G LGF + G Q Y+ VI A G LK GD+L+ VN V
Sbjct: 1597 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1654
Query: 152 QHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H AV LL+AA +V+LV+ RVLE
Sbjct: 1655 THTDAVNLLRAASKTVRLVI---GRVLE 1679
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 94 VELPKTDEGLGF------NIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S
Sbjct: 1311 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV-RYTPRVLEEME 182
++G ++ + L+ V L++ R P VL E++
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1406
Score = 37.0 bits (84), Expect = 0.012
Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 10/87 (11%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG-- 150
+ L E LGF++ GG + +YIS + P VA G L+ D + VNGVS +G
Sbjct: 1693 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1752
Query: 151 -EQHEKAVEL------LKAAQGSVKLV 170
E+ +A+++ LKA + + +V
Sbjct: 1753 LEEVNRALDMSLPSLVLKATRNDLPVV 1779
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 68.9 bits (167), Expect = 3e-12
Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 7/111 (6%)
Query: 102 GLGFNIMGGKEQNS---PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVE 158
GLGF I+GG++ I+IS V PGG AD G LK GD+L+SVN VS+EG H A+E
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 159 LLKAAQGSVKLVVRYTPRVLEEMEAR----FEKMRSARRRQQHQSYSSLES 205
+L+ A V LV+ + ++ + +M++ ++ + S+++S
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDS 1213
Score = 65.1 bits (157), Expect = 4e-11
Identities = 34/81 (41%), Positives = 51/81 (62%), Gaps = 3/81 (3%)
Query: 94 VELPKTDEGLGFNIMGGKE---QNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
VEL K D LG ++ GG ++ IY+ VIP G A+ G + +GD++L+VNGVS+EG
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428
Query: 151 EQHEKAVELLKAAQGSVKLVV 171
H++AVE L+ V L++
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLL 1449
Score = 45.4 bits (106), Expect = 3e-05
Identities = 35/88 (39%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 93 VVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
++ L K+++G LGF + G Q Y+ VI A G LK GD+L+ VN V
Sbjct: 1788 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1845
Query: 152 QHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H AV LL+AA +V+LV+ RVLE
Sbjct: 1846 THTDAVNLLRAASKTVRLVI---GRVLE 1870
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 94 VELPKTDEGLGF------NIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S
Sbjct: 1502 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV-RYTPRVLEEME 182
++G ++ + L+ V L++ R P VL E++
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1597
Score = 37.0 bits (84), Expect = 0.012
Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 10/87 (11%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG-- 150
+ L E LGF++ GG + +YIS + P VA G L+ D + VNGVS +G
Sbjct: 1884 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1943
Query: 151 -EQHEKAVEL------LKAAQGSVKLV 170
E+ +A+++ LKA + + +V
Sbjct: 1944 LEEVNRALDMSLPSLVLKATRNDLPVV 1970
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 68.9 bits (167), Expect = 3e-12
Identities = 40/111 (36%), Positives = 64/111 (57%), Gaps = 7/111 (6%)
Query: 102 GLGFNIMGGKEQNS---PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVE 158
GLGF I+GG++ I+IS V PGG AD G LK GD+L+SVN VS+EG H A+E
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 159 LLKAAQGSVKLVVRYTPRVLEEMEAR----FEKMRSARRRQQHQSYSSLES 205
+L+ A V LV+ + ++ + +M++ ++ + S+++S
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDS 1194
Score = 65.1 bits (157), Expect = 4e-11
Identities = 34/81 (41%), Positives = 51/81 (62%), Gaps = 3/81 (3%)
Query: 94 VELPKTDEGLGFNIMGGKE---QNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
VEL K D LG ++ GG ++ IY+ VIP G A+ G + +GD++L+VNGVS+EG
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409
Query: 151 EQHEKAVELLKAAQGSVKLVV 171
H++AVE L+ V L++
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLL 1430
Score = 45.4 bits (106), Expect = 3e-05
Identities = 35/88 (39%), Positives = 48/88 (54%), Gaps = 6/88 (6%)
Query: 93 VVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
++ L K+++G LGF + G Q Y+ VI A G LK GD+L+ VN V
Sbjct: 1769 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1826
Query: 152 QHEKAVELLKAAQGSVKLVVRYTPRVLE 179
H AV LL+AA +V+LV+ RVLE
Sbjct: 1827 THTDAVNLLRAASKTVRLVI---GRVLE 1851
Score = 43.5 bits (101), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 7/96 (7%)
Query: 94 VELPKTDEGLGF------NIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S
Sbjct: 1483 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV-RYTPRVLEEME 182
++G ++ + L+ V L++ R P VL E++
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEID 1578
Score = 37.0 bits (84), Expect = 0.012
Identities = 28/87 (32%), Positives = 45/87 (51%), Gaps = 10/87 (11%)
Query: 94 VELPKTDEGLGFNIMGGKEQ-NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG-- 150
+ L E LGF++ GG + +YIS + P VA G L+ D + VNGVS +G
Sbjct: 1865 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMT 1924
Query: 151 -EQHEKAVEL------LKAAQGSVKLV 170
E+ +A+++ LKA + + +V
Sbjct: 1925 LEEVNRALDMSLPSLVLKATRNDLPVV 1951
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 68.6 bits (166), Expect = 4e-12
Identities = 36/101 (35%), Positives = 58/101 (57%), Gaps = 13/101 (12%)
Query: 87 GHAHPRVVELPKTDEGLGFNIMGGKEQNSPI------------YISRVIPGGVADRHGGL 134
G PRVV + K++ G GFN+ G + + ++S V+PGG ADR G+
Sbjct: 37 GGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADR-AGV 95
Query: 135 KRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTP 175
++GD++L VN V+VEG H++ V+L++A + + L V P
Sbjct: 96 RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 67.4 bits (163), Expect = 8e-12
Identities = 33/86 (38%), Positives = 51/86 (59%), Gaps = 2/86 (2%)
Query: 90 HPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
H VEL GLGF I+GGK S + + ++PGG+ADR G L+ GD +L + G +V+
Sbjct: 245 HVEEVELINDGSGLGFGIVGGK--TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302
Query: 150 GEQHEKAVELLKAAQGSVKLVVRYTP 175
G E+ ++L+ SV+++V P
Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 61.2 bits (147), Expect = 6e-10
Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 18/144 (12%)
Query: 46 FCSAIREVYEQLYDTLDITGSAEIRAHATAK--ATVAAFTASEGHAHP------------ 91
F A+ ++ +Q Y T S EI + +T A FT G P
Sbjct: 1373 FKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVP 1432
Query: 92 ---RVVELPKTDEGLGFNIMGGKEQN-SPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
++E+ K GLG +I+GGK+ + I I V G A R G L GDQ+L VNGV
Sbjct: 1433 GQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV 171
+ HE+A+ L+ V+LVV
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVV 1516
Score = 61.2 bits (147), Expect = 6e-10
Identities = 32/74 (43%), Positives = 44/74 (59%), Gaps = 1/74 (1%)
Query: 98 KTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157
K GLG +I+G K S ++IS ++ GG AD G L +GDQ+LSVNG + E
Sbjct: 1539 KAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVA 1597
Query: 158 ELLKAAQGSVKLVV 171
+LK AQG V+L +
Sbjct: 1598 TILKCAQGLVQLEI 1611
Score = 55.8 bits (133), Expect = 2e-08
Identities = 32/86 (37%), Positives = 51/86 (59%), Gaps = 5/86 (5%)
Query: 94 VELPKTDEGLGFNIMGGKEQNS---PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
+E P T GLGF+++ + QN I++ V PG VADR LK DQ+L++N ++
Sbjct: 137 IERPSTG-GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQ 195
Query: 151 E-QHEKAVELLKAAQGSVKLVVRYTP 175
H++A+ LL+ GS++L+V P
Sbjct: 196 NISHQQAIALLQQTTGSLRLIVAREP 221
Score = 55.1 bits (131), Expect = 4e-08
Identities = 35/111 (31%), Positives = 60/111 (54%), Gaps = 13/111 (11%)
Query: 91 PRVVEL-PKTDEGLGFNIMGGK---------EQNSPIYISRVIPGGVADRHGGLKRGDQL 140
PR+VE+ + + LG +I+GG+ E+ I+I +V+ A + LK GD++
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 141 LSVNGVSVEGEQHEKAVELLKAAQGSVKLVVR---YTPRVLEEMEARFEKM 188
L V+GV ++ H +AVE +K A V +V+ TPRV+ + + K+
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKI 1176
Score = 54.3 bits (129), Expect = 7e-08
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 4/85 (4%)
Query: 91 PRVVELPKT-DEGLGFNIMGGKEQ---NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGV 146
PR VE+ + + LG +I GG+ + P++I+ + GVA R LK GD+++S+NG
Sbjct: 1674 PRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733
Query: 147 SVEGEQHEKAVELLKAAQGSVKLVV 171
++G H V LLK A G + L V
Sbjct: 1734 PLDGLSHADVVNLLKNAYGRIILQV 1758
Score = 53.9 bits (128), Expect = 9e-08
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 4/75 (5%)
Query: 92 RVVELPKTDEGLGFNIMGGKEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
++VEL K +GLGF+I+ ++ P I I ++ GVA+R GGL GD+L+SVN
Sbjct: 685 KIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744
Query: 148 VEGEQHEKAVELLKA 162
++ +AVE+LKA
Sbjct: 745 LDNTSLAEAVEILKA 759
Score = 53.9 bits (128), Expect = 9e-08
Identities = 27/79 (34%), Positives = 45/79 (56%), Gaps = 1/79 (1%)
Query: 93 VVELPKTDEGLGFNIMGGKEQNS-PIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
++EL K GLG ++ G K+++ I++ + P G A G ++ GD+LL +N + G
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
Query: 152 QHEKAVELLKAAQGSVKLV 170
H+ A ++K A VKLV
Sbjct: 1299 SHQNASAIIKTAPSKVKLV 1317
Score = 44.3 bits (103), Expect = 7e-05
Identities = 27/84 (32%), Positives = 48/84 (57%), Gaps = 6/84 (7%)
Query: 94 VELPKTD-EGLGFNIMG-----GKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
VEL + D + LG I+G + S IY+ +IPG A +G ++ D++++V+GV+
Sbjct: 366 VELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVN 425
Query: 148 VEGEQHEKAVELLKAAQGSVKLVV 171
++G + VE+L+ A V L +
Sbjct: 426 IQGFANHDVVEVLRNAGQVVHLTL 449
Score = 40.4 bits (93), Expect = 0.001
Identities = 38/155 (24%), Positives = 68/155 (43%), Gaps = 32/155 (20%)
Query: 18 VELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDTLD--ITGSAEIRAHATA 75
++ LE+L++ + P +L+ SR+ + + YE + TLD I AE++ ++
Sbjct: 510 IQALEKLEKVPDSPENELK-------SRWENLLGPDYEVMVATLDTQIADDAELQKYS-- 560
Query: 76 KATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLK 135
+++ + G+ + G YIS ++ GG D G L+
Sbjct: 561 ----------------KLLPIHTLRLGVEVDSFDGHH-----YISSIVSGGPVDTLGLLQ 599
Query: 136 RGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLV 170
D+LL VNG+ + G+ +AV LK LV
Sbjct: 600 PEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 67.0 bits (162), Expect = 1e-11
Identities = 42/114 (36%), Positives = 67/114 (58%), Gaps = 16/114 (14%)
Query: 71 AHATAKATVAAFTASEGHAHPRV-----VELPKTDEGLGFNI------MGGKEQNSPIYI 119
A A+A V + T S G+ ++ ++L K EGLGF+I +GG ++PIY+
Sbjct: 434 APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGG---SAPIYV 490
Query: 120 SRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAA--QGSVKLVV 171
++P G A + G LK GD+L+ VNGV + G+ E+ V LL++ +G+V L+V
Sbjct: 491 KNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLV 544
Score = 48.1 bits (113), Expect = 5e-06
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 24/134 (17%)
Query: 95 ELPKTDEG---LGFNIMGGKEQNSP----IYISRVIPGGVADRHGGLKRGDQLLSVNGVS 147
E+P D G LG ++ G + + + I++ +I GG A + G L+ DQL++VNG S
Sbjct: 590 EVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGES 649
Query: 148 VEGEQHEKAVELLKAA-------QGSVKLVVRYTPRVLEEMEARFE----------KMRS 190
+ G+ ++ A+E L+ + +G ++L+V E+++ +
Sbjct: 650 LLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIETALDD 709
Query: 191 ARRRQQHQSYSSLE 204
RR H YS +E
Sbjct: 710 RERRISHSLYSGIE 723
>gi|7706025 PDZ domain containing 11 [Homo sapiens]
Length = 140
Score = 67.0 bits (162), Expect = 1e-11
Identities = 40/86 (46%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 91 PRVVELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
PR + L K LGFNI GGK I+IS+VIP A R GL+ GDQ+L+VN V +
Sbjct: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103
Query: 150 GEQHEKAVELLKAAQGSVKLVVRYTP 175
+H KAVE+LK A+ + + VR+ P
Sbjct: 104 DIEHSKAVEILKTAR-EISMRVRFFP 128
>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
Length = 540
Score = 66.6 bits (161), Expect = 1e-11
Identities = 39/97 (40%), Positives = 54/97 (55%), Gaps = 3/97 (3%)
Query: 84 ASEGHAHP---RVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQL 140
A E A P RV + + GLG +I GG+E PI IS++ PG AD+ L+ GD +
Sbjct: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAI 163
Query: 141 LSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRV 177
LSVNG + H++AV+ LK A V L V++ V
Sbjct: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 65.1 bits (157), Expect = 4e-11
Identities = 34/82 (41%), Positives = 53/82 (64%), Gaps = 6/82 (7%)
Query: 96 LPKTDEGLGFNIMGGKEQ------NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
L +++ GLGF+I GGK ++ I++SR+ GG A R G L+ GD++LS+NGV V
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 150 GEQHEKAVELLKAAQGSVKLVV 171
+H+ AV LL AA ++ L++
Sbjct: 925 EARHDHAVSLLTAASPTIALLL 946
Score = 56.6 bits (135), Expect = 1e-08
Identities = 41/112 (36%), Positives = 58/112 (51%), Gaps = 13/112 (11%)
Query: 102 GLGFNIMGGKEQ------NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEK 155
GLG +I GGK + I+ISRV G A R G++ GD+LL VNGV+++G +H +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVALQGAEHHE 795
Query: 156 AVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG 207
AVE L+ A +V++ RV E E + + YS E RG
Sbjct: 796 AVEALRGAGTAVQM------RVWRERMVEPENAVTITPLRPEDDYSPRERRG 841
Score = 55.1 bits (131), Expect = 4e-08
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 84 ASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSP--------IYISRVIPGGVADRHGGLK 135
A EG + LP+ LG +I+GG + +S ++IS+V+P G+A R GL+
Sbjct: 995 ALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLR 1053
Query: 136 RGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTP 175
GD++L+VNG V H++AV L + L+VR P
Sbjct: 1054 VGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
Score = 44.3 bits (103), Expect = 7e-05
Identities = 29/80 (36%), Positives = 45/80 (56%), Gaps = 9/80 (11%)
Query: 101 EGLGFNIMGGKEQNSP---------IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
E LG +I GG ++ I+IS+V P G A R G L+ G +LL VN S+ G
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 152 QHEKAVELLKAAQGSVKLVV 171
H +AV+LL++ ++ ++V
Sbjct: 1169 THGEAVQLLRSVGDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 65.1 bits (157), Expect = 4e-11
Identities = 34/82 (41%), Positives = 53/82 (64%), Gaps = 6/82 (7%)
Query: 96 LPKTDEGLGFNIMGGKEQ------NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
L +++ GLGF+I GGK ++ I++SR+ GG A R G L+ GD++LS+NGV V
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 150 GEQHEKAVELLKAAQGSVKLVV 171
+H+ AV LL AA ++ L++
Sbjct: 925 EARHDHAVSLLTAASPTIALLL 946
Score = 56.6 bits (135), Expect = 1e-08
Identities = 41/112 (36%), Positives = 58/112 (51%), Gaps = 13/112 (11%)
Query: 102 GLGFNIMGGKEQ------NSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEK 155
GLG +I GGK + I+ISRV G A R G++ GD+LL VNGV+++G +H +
Sbjct: 737 GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR-AGVRVGDKLLEVNGVALQGAEHHE 795
Query: 156 AVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHQSYSSLESRG 207
AVE L+ A +V++ RV E E + + YS E RG
Sbjct: 796 AVEALRGAGTAVQM------RVWRERMVEPENAVTITPLRPEDDYSPRERRG 841
Score = 55.1 bits (131), Expect = 4e-08
Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 84 ASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSP--------IYISRVIPGGVADRHGGLK 135
A EG + LP+ LG +I+GG + +S ++IS+V+P G+A R GL+
Sbjct: 995 ALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLR 1053
Query: 136 RGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTP 175
GD++L+VNG V H++AV L + L+VR P
Sbjct: 1054 VGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093
Score = 44.3 bits (103), Expect = 7e-05
Identities = 29/80 (36%), Positives = 45/80 (56%), Gaps = 9/80 (11%)
Query: 101 EGLGFNIMGGKEQNSP---------IYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGE 151
E LG +I GG ++ I+IS+V P G A R G L+ G +LL VN S+ G
Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168
Query: 152 QHEKAVELLKAAQGSVKLVV 171
H +AV+LL++ ++ ++V
Sbjct: 1169 THGEAVQLLRSVGDTLTVLV 1188
>gi|13376349 PDZ domain containing 7 [Homo sapiens]
Length = 517
Score = 64.7 bits (156), Expect = 5e-11
Identities = 39/87 (44%), Positives = 55/87 (63%), Gaps = 4/87 (4%)
Query: 92 RVVELPKTDEG--LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVE 149
R+V L T + LGFNI GGKE IY+S+V GG+A+ + G+K GDQ+L+ NGV +
Sbjct: 209 RIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEEN-GIKVGDQVLAANGVRFD 267
Query: 150 GEQHEKAVELLKAAQGSVKLVVRYTPR 176
H +AVE+LK Q + L ++ T R
Sbjct: 268 DISHSQAVEVLK-GQTHIMLTIKETGR 293
Score = 47.0 bits (110), Expect = 1e-05
Identities = 31/85 (36%), Positives = 49/85 (57%), Gaps = 3/85 (3%)
Query: 94 VELPKTDEG-LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQ 152
V + K+ G LGF++ GG E I++S+V G A+R GL GD++ VNG+S+E
Sbjct: 87 VRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAER-AGLCVGDKITEVNGLSLESTT 145
Query: 153 HEKAVELLKAAQGSVKLVVRYTPRV 177
AV++L + + ++VR RV
Sbjct: 146 MGSAVKVL-TSSSRLHMMVRRMGRV 169
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.358
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,913,323
Number of Sequences: 37866
Number of extensions: 271149
Number of successful extensions: 1518
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 1037
Number of HSP's gapped (non-prelim): 397
length of query: 207
length of database: 18,247,518
effective HSP length: 98
effective length of query: 109
effective length of database: 14,536,650
effective search space: 1584494850
effective search space used: 1584494850
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.