Search of human proteins with 11545847

Search of human proteins with 11545847

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo
sapiens]
         (901 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]   1806   0.0  
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]   1795   0.0  
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]              468   e-132
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]        301   2e-81
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]     301   2e-81
gi|21614542 single-minded homolog 1 [Homo sapiens]                    298   2e-80
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ...   247   3e-65
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [...   247   3e-65
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]           229   9e-60
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ...   216   1e-55
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ...   216   1e-55
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ...   168   2e-41
gi|4502003 aryl hydrocarbon receptor [Homo sapiens]                   133   8e-31
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...   107   5e-23
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...   107   7e-23
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...   107   7e-23
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...   107   7e-23
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...   100   1e-20
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo...    97   5e-20
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho...    92   2e-18
gi|4758010 clock [Homo sapiens]                                        88   3e-17
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]         83   1e-15
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]               80   7e-15
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]              78   4e-14
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]    72   3e-12
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]    72   3e-12
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]    72   3e-12
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...    71   5e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    67   6e-11
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]               64   8e-10

>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
          Length = 901

 Score = 1806 bits (4679), Expect = 0.0
 Identities = 901/901 (100%), Positives = 901/901 (100%)

Query: 1   MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60
           MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK
Sbjct: 1   MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60

Query: 61  ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGS 120
           ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGS
Sbjct: 61  ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGS 120

Query: 121 HILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM 180
           HILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM
Sbjct: 121 HILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM 180

Query: 181 KLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLT 240
           KLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLT
Sbjct: 181 KLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLT 240

Query: 241 KRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHM 300
           KRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHM
Sbjct: 241 KRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHM 300

Query: 301 FVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV 360
           FVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV
Sbjct: 301 FVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV 360

Query: 361 TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP 420
           TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP
Sbjct: 361 TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP 420

Query: 421 EKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN 480
           EKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN
Sbjct: 421 EKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN 480

Query: 481 CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 540
           CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC
Sbjct: 481 CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 540

Query: 541 ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVE 600
           ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVE
Sbjct: 541 ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVE 600

Query: 601 PPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFP 660
           PPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFP
Sbjct: 601 PPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFP 660

Query: 661 SPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLS 720
           SPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLS
Sbjct: 661 SPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLS 720

Query: 721 ASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGT 780
           ASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGT
Sbjct: 721 ASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEALQRLQAGNVVLPLVHRVTGT 780

Query: 781 LAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEML 840
           LAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEML
Sbjct: 781 LAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNFVDVNSPGFGLDPKTPMEML 840

Query: 841 YHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKE 900
           YHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKE
Sbjct: 841 YHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTLPFPVYSNGIHAAQTLERKE 900

Query: 901 D 901
           D
Sbjct: 901 D 901


>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
          Length = 920

 Score = 1795 bits (4649), Expect = 0.0
 Identities = 901/920 (97%), Positives = 901/920 (97%), Gaps = 19/920 (2%)

Query: 1   MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60
           MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK
Sbjct: 1   MAPTKPSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDK 60

Query: 61  ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKG-------------------AQ 101
           ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKG                   AQ
Sbjct: 61  ASIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQ 120

Query: 102 RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS 161
           RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS
Sbjct: 121 RRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSS 180

Query: 162 VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL 221
           VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL
Sbjct: 181 VFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLL 240

Query: 222 TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV 281
           TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV
Sbjct: 241 TTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVV 300

Query: 282 VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE 341
           VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE
Sbjct: 301 VAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAE 360

Query: 342 DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL 401
           DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL
Sbjct: 361 DVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLL 420

Query: 402 SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS 461
           SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS
Sbjct: 421 SNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENS 480

Query: 462 EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM 521
           EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM
Sbjct: 481 EDPEPDRKKSGNACDNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAM 540

Query: 522 QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 581
           QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS
Sbjct: 541 QIKVERYVESESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 600

Query: 582 RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI 641
           RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI
Sbjct: 601 RRRLSSASSPGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREI 660

Query: 642 SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA 701
           SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA
Sbjct: 661 SRNESPYSMTKPPSSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGA 720

Query: 702 SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL 761
           SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL
Sbjct: 721 SATAALAPVASDPLSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNSLLYTGDLEAL 780

Query: 762 QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF 821
           QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF
Sbjct: 781 QRLQAGNVVLPLVHRVTGTLAATSTAAQRVYTTGTIRYAPAEVTLAMQSNLLPNAHAVNF 840

Query: 822 VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL 881
           VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL
Sbjct: 841 VDVNSPGFGLDPKTPMEMLYHHVHRLNMSGPFGGAVSAASLTQMPAGNVFTTAEGLFSTL 900

Query: 882 PFPVYSNGIHAAQTLERKED 901
           PFPVYSNGIHAAQTLERKED
Sbjct: 901 PFPVYSNGIHAAQTLERKED 920


>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
          Length = 590

 Score =  468 bits (1205), Expect = e-132
 Identities = 244/463 (52%), Positives = 319/463 (68%), Gaps = 37/463 (7%)

Query: 18  LQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFA 77
           LQA RKEKSR+AARSRRGKEN EF+ELAKLLPLP AI+SQLDKASI+RL+++YL++R FA
Sbjct: 42  LQAQRKEKSRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFA 101

Query: 78  NQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEG 137
             G PPW LR  GPP       A  RR P+AL  EVFE HLG HILQSLDGFVFALNQEG
Sbjct: 102 ALGAPPWGLRAAGPPAGL----APGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEG 157

Query: 138 KFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLP-PGRGLLSQGTAED 196
           KFLYISETVSIYLGLSQVE+TGSSVFDY+HPGDH E+ EQLG++ P PG           
Sbjct: 158 KFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQLGLRTPTPG----PPTPPSV 213

Query: 197 GASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHI 256
            +SS+SSSS ++TPE +E++   +  +    ERSFF+RMKSTLTKRG+H+K+SGYKVIH+
Sbjct: 214 SSSSSSSSSLADTPE-IEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHV 272

Query: 257 TGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCEN 316
           TGRLR            +  +GLV + H LPP  + E+ +  HM V R+++ L I+ CE+
Sbjct: 273 TGRLR------------AHALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACES 320

Query: 317 RISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWI 376
           R+SD+MDL P ++VG+ CY F+H +D   IR SH+DLL+KGQ +T YYRW+Q+ GG++W+
Sbjct: 321 RVSDHMDLGPSELVGRSCYQFVHGQDATRIRQSHVDLLDKGQVMTGYYRWLQRAGGFVWL 380

Query: 377 QSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHL---------------PE 421
           QS AT+A + K+  E +++WV+++LS  E   TP+D  QLP                 PE
Sbjct: 381 QSVATVAGSGKSPGEHHVLWVSHVLSQAEGGQTPLDAFQLPASVACEEASSPGPEPTEPE 440

Query: 422 KTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDP 464
             +E  + + +E+++  T G     E    + KG++    EDP
Sbjct: 441 PPTEGKQAAPAENEAPQTQGKRIKVEPGPRETKGSEDSGDEDP 483


>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
          Length = 667

 Score =  301 bits (771), Expect = 2e-81
 Identities = 173/418 (41%), Positives = 242/418 (57%), Gaps = 54/418 (12%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
           KEKS++AA++RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR    +G  
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
             W              G   R  P    ++     LGSH+LQ+LDGFVF +  +GK +Y
Sbjct: 62  DAW--------------GQPSRAGP----LDGVAKELGSHLLQTLDGFVFVVASDGKIMY 103

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
           ISET S++LGLSQVELTG+S+++Y+HP DH EM   L    P    LL +          
Sbjct: 104 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQE---------- 153

Query: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR 261
                                    +ERSFF+RMK  L KR   +  SGYKVIH +G L+
Sbjct: 154 -----------------------YEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLK 190

Query: 262 LRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRIS 319
           +R  +       S  QI+GLV V  +LPP  I E+++  +MF+ R ++DL +I+ ++R++
Sbjct: 191 IRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVT 250

Query: 320 DYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSS 379
           +     P D++ K  YH +H  DV  +R++H  LL KGQ  TKYYR + K GG++W+QS 
Sbjct: 251 EVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSY 310

Query: 380 ATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSK 437
           AT+  N++++    I+ VNY+L+  EYK+  + + Q+     + S  +  S S+   K
Sbjct: 311 ATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRK 368


>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
          Length = 570

 Score =  301 bits (771), Expect = 2e-81
 Identities = 173/418 (41%), Positives = 242/418 (57%), Gaps = 54/418 (12%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
           KEKS++AA++RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR    +G  
Sbjct: 2   KEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLG 61

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
             W              G   R  P    ++     LGSH+LQ+LDGFVF +  +GK +Y
Sbjct: 62  DAW--------------GQPSRAGP----LDGVAKELGSHLLQTLDGFVFVVASDGKIMY 103

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
           ISET S++LGLSQVELTG+S+++Y+HP DH EM   L    P    LL +          
Sbjct: 104 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQE---------- 153

Query: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR 261
                                    +ERSFF+RMK  L KR   +  SGYKVIH +G L+
Sbjct: 154 -----------------------YEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLK 190

Query: 262 LRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRIS 319
           +R  +       S  QI+GLV V  +LPP  I E+++  +MF+ R ++DL +I+ ++R++
Sbjct: 191 IRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVT 250

Query: 320 DYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSS 379
           +     P D++ K  YH +H  DV  +R++H  LL KGQ  TKYYR + K GG++W+QS 
Sbjct: 251 EVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSY 310

Query: 380 ATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSK 437
           AT+  N++++    I+ VNY+L+  EYK+  + + Q+     + S  +  S S+   K
Sbjct: 311 ATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRK 368


>gi|21614542 single-minded homolog 1 [Homo sapiens]
          Length = 766

 Score =  298 bits (762), Expect = 2e-80
 Identities = 174/447 (38%), Positives = 251/447 (56%), Gaps = 63/447 (14%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG-D 81
           KEKS++AAR+RR KEN EFYELAKLLPLP+AITSQLDKASIIRLT SYLKMR    +G  
Sbjct: 2   KEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
             W              G   R SP    ++     LGSH+LQ+LDGF+F +  +GK +Y
Sbjct: 62  EAW--------------GHSSRTSP----LDNVGRELGSHLLQTLDGFIFVVAPDGKIMY 103

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
           ISET S++LGLSQVELTG+S+++Y+HP DH EM   L    P                  
Sbjct: 104 ISETASVHLGLSQVELTGNSIYEYIHPADHDEMTAVLTAHQP------------------ 145

Query: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLR 261
                            S    +  +ERSFF+RMK  L KR   +   GYKVIH +G L+
Sbjct: 146 ---------------YHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGYKVIHCSGYLK 190

Query: 262 LRVSLSHGRTVPS--QIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRIS 319
           +R             Q +GLV V H+LPP  + E+++  +MF+ R ++D+ +I+ ++R++
Sbjct: 191 IRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDMKLIFLDSRVA 250

Query: 320 DYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSS 379
           +     P D++ K  YH +H  D   +R +H  LL KGQ  TKYYR++ K+GG++W+QS 
Sbjct: 251 ELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAKHGGWVWVQSY 310

Query: 380 ATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDT 439
           ATI  N++++    I+ VNY+L++ EYK   + + Q+         S+        S  T
Sbjct: 311 ATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI---------SASKPAFSYTSSST 361

Query: 440 SGITEDNENSKSDEKGNQSENSEDPEP 466
             +T++ + +KS    ++S++   P P
Sbjct: 362 PTMTDNRKGAKSRLSSSKSKSRTSPYP 388


>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
           [Homo sapiens]
          Length = 735

 Score =  247 bits (631), Expect = 3e-65
 Identities = 153/430 (35%), Positives = 234/430 (54%), Gaps = 70/430 (16%)

Query: 22  RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81
           RKEKSRDAARSRR KE+  FYELA  LPLP  ++S LDKAS++RLTISYL++R   + GD
Sbjct: 18  RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
               L +E                      +  +A +    L++LDGFV  L  +G  +Y
Sbjct: 78  ----LDIE----------------------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY 111

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
           IS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L  +     GL+ +G  ++     
Sbjct: 112 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR----NGLVKKGKEQN----- 162

Query: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITGR 259
                                     +RSFF+RMK TLT RG  ++IKS+ +KV+H TG 
Sbjct: 163 -------------------------TQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGH 197

Query: 260 LRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCE 315
           + +  + S+    G   P     LV++   +P P+  E+ +D   F++R ++D+   YC+
Sbjct: 198 IHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCD 256

Query: 316 NRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIW 375
            RI++ M   P +++G+  Y + HA D + +  +H D+  KGQ  T  YR + K GGY+W
Sbjct: 257 ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVW 316

Query: 376 IQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHL--PEKTSESSETS-DS 432
           +++ AT+  N KN+  + I+ VNY++S     D    + Q   +  P ++S+   T   +
Sbjct: 317 VETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFT 376

Query: 433 ESDSKDTSGI 442
           + +S+DTS +
Sbjct: 377 KVESEDTSSL 386


>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
           [Homo sapiens]
          Length = 826

 Score =  247 bits (631), Expect = 3e-65
 Identities = 153/430 (35%), Positives = 234/430 (54%), Gaps = 70/430 (16%)

Query: 22  RKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGD 81
           RKEKSRDAARSRR KE+  FYELA  LPLP  ++S LDKAS++RLTISYL++R   + GD
Sbjct: 18  RKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD 77

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLY 141
               L +E                      +  +A +    L++LDGFV  L  +G  +Y
Sbjct: 78  ----LDIE----------------------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY 111

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
           IS+ V+ Y+GL+Q ELTG SVFD+ HP DH EM E L  +     GL+ +G  ++     
Sbjct: 112 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR----NGLVKKGKEQN----- 162

Query: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITGR 259
                                     +RSFF+RMK TLT RG  ++IKS+ +KV+H TG 
Sbjct: 163 -------------------------TQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGH 197

Query: 260 LRLRVSLSH----GRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCE 315
           + +  + S+    G   P     LV++   +P P+  E+ +D   F++R ++D+   YC+
Sbjct: 198 IHVYDTNSNQPQCGYKKPPMTC-LVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCD 256

Query: 316 NRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIW 375
            RI++ M   P +++G+  Y + HA D + +  +H D+  KGQ  T  YR + K GGY+W
Sbjct: 257 ERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVW 316

Query: 376 IQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHL--PEKTSESSETS-DS 432
           +++ AT+  N KN+  + I+ VNY++S     D    + Q   +  P ++S+   T   +
Sbjct: 317 VETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFT 376

Query: 433 ESDSKDTSGI 442
           + +S+DTS +
Sbjct: 377 KVESEDTSSL 386


>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
          Length = 870

 Score =  229 bits (584), Expect = 9e-60
 Identities = 137/420 (32%), Positives = 221/420 (52%), Gaps = 67/420 (15%)

Query: 11  DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
           D  ++      RKEKSRDAAR RR KE   FYELA  LPLP +++S LDKASI+RL IS+
Sbjct: 4   DKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISF 63

Query: 71  LKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFV 130
           L+     +                 SV       + +       +  + +  L++L+GF+
Sbjct: 64  LRTHKLLS-----------------SVCSENESEAEA-------DQQMDNLYLKALEGFI 99

Query: 131 FALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLS 190
             + Q+G  +++SE +S ++GL+QVELTG S+FD+ HP DH E+ E L +K   G G  S
Sbjct: 100 AVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKS 159

Query: 191 QGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKS 248
           +                                D + ER FF+RMK T+T RG  V++KS
Sbjct: 160 K--------------------------------DMSTERDFFMRMKCTVTNRGRTVNLKS 187

Query: 249 SGYKVIHITGRLRLRVSLSHGRTVPSQ----IMGLVVVAHALPPPTINEVRIDCHMFVTR 304
           + +KV+H TG++++  +     ++       +  L+++   +  P+  ++ +D   F++R
Sbjct: 188 ATWKVLHCTGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSR 247

Query: 305 VNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYY 364
            +MD+   YC++RI++ +   P +++G+  Y F HA D E +  SH +L  KGQ V+  Y
Sbjct: 248 HSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQY 307

Query: 365 RWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL-----PHL 419
           R + K+GGY+W+++  T+  N +N   + I+ VNY+LS  E  D    + Q      PHL
Sbjct: 308 RMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHL 367


>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
           [Homo sapiens]
          Length = 667

 Score =  216 bits (549), Expect = 1e-55
 Identities = 140/432 (32%), Positives = 221/432 (51%), Gaps = 71/432 (16%)

Query: 21  LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
           LRKEKSRDAARSRR +E    Y+LA  LP    +++ LDKASI+RLTISYL+M      G
Sbjct: 12  LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 71

Query: 81  DPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFL 140
           +  WN    G  P                        L +  L++L+GFV  L  EG   
Sbjct: 72  E--WNQVGAGGEP------------------------LDACYLKALEGFVMVLTAEGDMA 105

Query: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
           Y+SE VS +LGLSQ+EL G S+FD++HP D  E+ + L                      
Sbjct: 106 YLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL---------------------- 143

Query: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITG 258
             +  Q+ +   VE+ +          ER F +RMKSTLT RG  +++K++ +KV++ +G
Sbjct: 144 --TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSG 191

Query: 259 RLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIY 313
            +R      + S +        +  LV++  A+P P   E  +    F++R ++D+   Y
Sbjct: 192 HMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTY 251

Query: 314 CENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGY 373
           C++RI++    +P D++G   Y +IHA D + +  S   LL+KGQ VT  YR++ ++GGY
Sbjct: 252 CDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGY 311

Query: 374 IWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP----EKTSESSET 429
           +W Q+ AT+    +    ++I+ V++L+S  E     + + Q         ++ + S + 
Sbjct: 312 LWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKD 371

Query: 430 SDSESDSKDTSG 441
           + +  DS DT G
Sbjct: 372 TPNPGDSLDTPG 383


>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
           [Homo sapiens]
          Length = 669

 Score =  216 bits (549), Expect = 1e-55
 Identities = 140/432 (32%), Positives = 221/432 (51%), Gaps = 71/432 (16%)

Query: 21  LRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQG 80
           LRKEKSRDAARSRR +E    Y+LA  LP    +++ LDKASI+RLTISYL+M      G
Sbjct: 14  LRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAG 73

Query: 81  DPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFL 140
           +  WN    G  P                        L +  L++L+GFV  L  EG   
Sbjct: 74  E--WNQVGAGGEP------------------------LDACYLKALEGFVMVLTAEGDMA 107

Query: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
           Y+SE VS +LGLSQ+EL G S+FD++HP D  E+ + L                      
Sbjct: 108 YLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL---------------------- 145

Query: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG--VHIKSSGYKVIHITG 258
             +  Q+ +   VE+ +          ER F +RMKSTLT RG  +++K++ +KV++ +G
Sbjct: 146 --TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSRGRTLNLKAATWKVLNCSG 193

Query: 259 RLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIY 313
            +R      + S +        +  LV++  A+P P   E  +    F++R ++D+   Y
Sbjct: 194 HMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTY 253

Query: 314 CENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGY 373
           C++RI++    +P D++G   Y +IHA D + +  S   LL+KGQ VT  YR++ ++GGY
Sbjct: 254 CDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQYRFLARSGGY 313

Query: 374 IWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLP----EKTSESSET 429
           +W Q+ AT+    +    ++I+ V++L+S  E     + + Q         ++ + S + 
Sbjct: 314 LWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAPSQKD 373

Query: 430 SDSESDSKDTSG 441
           + +  DS DT G
Sbjct: 374 TPNPGDSLDTPG 385


>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
           [Homo sapiens]
          Length = 613

 Score =  168 bits (426), Expect = 2e-41
 Identities = 114/389 (29%), Positives = 190/389 (48%), Gaps = 71/389 (18%)

Query: 64  IRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHIL 123
           +RLTISYL+M      G+  WN    G  P                        L +  L
Sbjct: 1   MRLTISYLRMHRLCAAGE--WNQVGAGGEP------------------------LDACYL 34

Query: 124 QSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLP 183
           ++L+GFV  L  EG   Y+SE VS +LGLSQ+EL G S+FD++HP D  E+ + L     
Sbjct: 35  KALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDAL----- 89

Query: 184 PGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRG 243
                              +  Q+ +   VE+ +          ER F +RMKSTLT RG
Sbjct: 90  -------------------TPQQTLSRRKVEAPT----------ERCFSLRMKSTLTSRG 120

Query: 244 --VHIKSSGYKVIHITGRLRL-----RVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRI 296
             +++K++ +KV++ +G +R      + S +        +  LV++  A+P P   E  +
Sbjct: 121 RTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPL 180

Query: 297 DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNK 356
               F++R ++D+   YC++RI++    +P D++G   Y +IHA D + +  S   LL+K
Sbjct: 181 GRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSK 240

Query: 357 GQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQL 416
           GQ VT  YR++ ++GGY+W Q+ AT+    +    ++I+ V++L+S  E     + + Q 
Sbjct: 241 GQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQT 300

Query: 417 PHLP----EKTSESSETSDSESDSKDTSG 441
                   ++ + S + + +  DS DT G
Sbjct: 301 EQHSRRPIQRGAPSQKDTPNPGDSLDTPG 329


>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
          Length = 848

 Score =  133 bits (334), Expect = 8e-31
 Identities = 120/471 (25%), Positives = 203/471 (43%), Gaps = 58/471 (12%)

Query: 30  ARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWNLRME 89
           ++  R + N E   LA LLP P  + ++LDK S++RL++SYL+ + F       +++ ++
Sbjct: 36  SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSF-------FDVALK 88

Query: 90  GPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETVSIY 149
             P  T   G Q     +A   E      G  +LQ+L+GFV  +  +    Y S T+  Y
Sbjct: 89  SSP--TERNGGQDN-CRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDY 145

Query: 150 LGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASSSSQSET 209
           LG  Q ++   SV++ +H  D  E   QL   L P     SQ T     S       +  
Sbjct: 146 LGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP-----SQCT----ESGQGIEEATGL 196

Query: 210 PEPVESTSPSLLTTDNT--LERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRL----R 263
           P+ V   +P  +  +N+  +ER F  R++  L        SSG+  ++  G+L+     +
Sbjct: 197 PQTVVCYNPDQIPPENSPLMERCFICRLRCLLD------NSSGFLAMNFQGKLKYLHGQK 250

Query: 264 VSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMD 323
                G  +P Q + L  +A  L PP+I E+R    +F T+  +D   I C+ +    + 
Sbjct: 251 KKGKDGSILPPQ-LALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLG 309

Query: 324 LTPVDIVGKRC-YHFIHAEDVEGIRHSHLDLLNKGQCVTKYYRWMQKNGGYIWIQSSATI 382
            T  ++  +   Y FIHA D+     SH+ ++  G+     +R + KN  + W+QS+A +
Sbjct: 310 YTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARL 369

Query: 383 AINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGI 442
                           Y    P+Y    + + Q P   E+ +E     +++     T+G 
Sbjct: 370 L---------------YKNGRPDY----IIVTQRPLTDEEGTEHLRKRNTKLPFMFTTG- 409

Query: 443 TEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDDGHSSSNPDS 493
                 +   E  N      DP P R K+G +  +    +     S NP S
Sbjct: 410 -----EAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSS 455


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score =  107 bits (267), Expect = 5e-23
 Identities = 115/447 (25%), Positives = 195/447 (43%), Gaps = 71/447 (15%)

Query: 10  QDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTIS 69
           +D   + +++A R+  S+   R RR K N    EL+ ++P    +  +LDK +++R+ + 
Sbjct: 97  EDGEHQVKMKAFREAHSQTEKR-RRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQ 155

Query: 70  YLK-MRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDG 128
           +L+ ++   N                 S  G+  R  PS L     +  L   IL++ +G
Sbjct: 156 HLRSLKGLTN-----------------SYVGSNYR--PSFLQ----DNELRHLILKTAEG 192

Query: 129 FVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL-GMKLPPGR 186
           F+F +  E GK L++S++VS  L   Q  LTG S+FD++HP D  ++ EQL    + P  
Sbjct: 193 FLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLHPKDVAKVKEQLSSFDISPRE 252

Query: 187 GLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTL------- 239
            L+    A+ G    S+     T   V S S           RSFF R+KS         
Sbjct: 253 KLID---AKTGLQVHSNLHAGRT--RVYSGS----------RRSFFCRIKSCKISVKEEH 297

Query: 240 -----TKRGVHIKSSGYKVIHITGRLRL----RVSLSHGRTVP---SQIMGLVVVAHALP 287
                +K+  H K   +  IH TG LR      V +   R      S    LV +    P
Sbjct: 298 GCLPNSKKKEHRK---FYTIHCTGYLRSWPPNIVGMEEERNSKKDNSNFTCLVAIGRLQP 354

Query: 288 ---PPTINEVRIDCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVE 344
              P    E+ +    F+TR  ++   +Y + R +  +   P +++G  CY + H +D  
Sbjct: 355 YIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQELLGTSCYEYFHQDDHN 414

Query: 345 GIRHSHLDLL-NKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSN 403
            +   H  +L +K + +T  Y++  K+G ++ ++S      N      + I+ VN L+  
Sbjct: 415 NLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTNPWTKELEYIVSVNTLVLG 474

Query: 404 PEYKDTPMDIAQLPHLPEKTSESSETS 430
                 P + + LP   + + ESS  S
Sbjct: 475 ---HSEPGEASFLPCSSQSSEESSRQS 498


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score =  107 bits (266), Expect = 7e-23
 Identities = 98/381 (25%), Positives = 167/381 (43%), Gaps = 62/381 (16%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
           +E      + RR K N    ELA L+P   A++ +LDK +++R+ + ++K +R   N   
Sbjct: 31  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 87

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN-QEGKFL 140
                      P T     +    P+ L+ +  + HL   IL++ DGF+F +    GK L
Sbjct: 88  -----------PYT-----EANYKPTFLSDDELK-HL---ILRAADGFLFVVGCDRGKIL 127

Query: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
           ++SE+V   L  SQ +L G S+FDY+HP D  ++ EQL       R  L        A +
Sbjct: 128 FVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLID------AKT 181

Query: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKS-----------S 249
                   TP P    S +         RSFF RMK       V  K             
Sbjct: 182 GLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRK 233

Query: 250 GYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV----AHALPPPTINEVRIDC 298
            +  IH TG L+     ++ L       ++   +  LV +    +H +P P   E+R+  
Sbjct: 234 SFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKS 293

Query: 299 HMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKG 357
             +V+R  +D   ++ + R +  +   P +++G  CY + H +D+  +   H  +L  + 
Sbjct: 294 MEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTRE 353

Query: 358 QCVTKYYRWMQKNGGYIWIQS 378
           +  T  Y++  K+G +I ++S
Sbjct: 354 KITTNCYKFKIKDGSFITLRS 374


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score =  107 bits (266), Expect = 7e-23
 Identities = 98/381 (25%), Positives = 167/381 (43%), Gaps = 62/381 (16%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
           +E      + RR K N    ELA L+P   A++ +LDK +++R+ + ++K +R   N   
Sbjct: 74  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 130

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN-QEGKFL 140
                      P T     +    P+ L+ +  + HL   IL++ DGF+F +    GK L
Sbjct: 131 -----------PYT-----EANYKPTFLSDDELK-HL---ILRAADGFLFVVGCDRGKIL 170

Query: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
           ++SE+V   L  SQ +L G S+FDY+HP D  ++ EQL       R  L        A +
Sbjct: 171 FVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLID------AKT 224

Query: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKS-----------S 249
                   TP P    S +         RSFF RMK       V  K             
Sbjct: 225 GLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRK 276

Query: 250 GYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV----AHALPPPTINEVRIDC 298
            +  IH TG L+     ++ L       ++   +  LV +    +H +P P   E+R+  
Sbjct: 277 SFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKS 336

Query: 299 HMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKG 357
             +V+R  +D   ++ + R +  +   P +++G  CY + H +D+  +   H  +L  + 
Sbjct: 337 MEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTRE 396

Query: 358 QCVTKYYRWMQKNGGYIWIQS 378
           +  T  Y++  K+G +I ++S
Sbjct: 397 KITTNCYKFKIKDGSFITLRS 417


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score =  107 bits (266), Expect = 7e-23
 Identities = 98/381 (25%), Positives = 167/381 (43%), Gaps = 62/381 (16%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLK-MRDFANQGD 81
           +E      + RR K N    ELA L+P   A++ +LDK +++R+ + ++K +R   N   
Sbjct: 74  REAHSQIEKRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATN--- 130

Query: 82  PPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALN-QEGKFL 140
                      P T     +    P+ L+ +  + HL   IL++ DGF+F +    GK L
Sbjct: 131 -----------PYT-----EANYKPTFLSDDELK-HL---ILRAADGFLFVVGCDRGKIL 170

Query: 141 YISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASS 200
           ++SE+V   L  SQ +L G S+FDY+HP D  ++ EQL       R  L        A +
Sbjct: 171 FVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLID------AKT 224

Query: 201 ASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKS-----------S 249
                   TP P    S +         RSFF RMK       V  K             
Sbjct: 225 GLPVKTDITPGPSRLCSGA--------RRSFFCRMKCNRPSVKVEDKDFPSTCSKKKDRK 276

Query: 250 GYKVIHITGRLR----LRVSLSHGRTVPSQ---IMGLVVV----AHALPPPTINEVRIDC 298
            +  IH TG L+     ++ L       ++   +  LV +    +H +P P   E+R+  
Sbjct: 277 SFCTIHSTGYLKSWPPTKMGLDEDNEPDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKS 336

Query: 299 HMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLL-NKG 357
             +V+R  +D   ++ + R +  +   P +++G  CY + H +D+  +   H  +L  + 
Sbjct: 337 MEYVSRHAIDGKFVFVDQRATAILAYLPQELLGTSCYEYFHQDDIGHLAECHRQVLQTRE 396

Query: 358 QCVTKYYRWMQKNGGYIWIQS 378
           +  T  Y++  K+G +I ++S
Sbjct: 397 KITTNCYKFKIKDGSFITLRS 417


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 42/419 (10%)

Query: 9   QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
           +Q  + +ERL    +E   +  R RR K      EL+ ++P  +A+  + DK +I+R+ +
Sbjct: 80  EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136

Query: 69  SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDG 128
           S++K            +LR  G   NTS  G+ +   PS L  +  + HL   IL++ DG
Sbjct: 137 SHMK------------SLRGTG---NTSTDGSYK---PSFLTDQELK-HL---ILEAADG 174

Query: 129 FVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM--KLPPG 185
           F+F ++ E G+ +Y+S++V+  L   Q E  GS+++D VHP D  ++ EQL        G
Sbjct: 175 FLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTG 234

Query: 186 RGL-LSQGTA--EDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKR 242
           R L L  GT   E   SS      S           S      ++ R  F+R +      
Sbjct: 235 RILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLG 294

Query: 243 GVHIKSSGYKVIHITGRLR----LRVSLSHGRTVPSQIMGLVVVA----HALPPPTINEV 294
            V      + V+H TG ++      VSL        Q     +VA         P   ++
Sbjct: 295 SVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDM 354

Query: 295 RIDCH--MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLD 352
              C    F++R N++    + ++R    +   P +++GK    F H ED + +R S   
Sbjct: 355 SNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQ 414

Query: 353 LLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTP 410
           ++  KGQ ++  +R+  KN  ++W+++S+    N  +   + II  N  + N   +  P
Sbjct: 415 VVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRP 473


>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
           3 [Homo sapiens]
          Length = 774

 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 105/405 (25%), Positives = 180/405 (44%), Gaps = 39/405 (9%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
           +E   +  R RR K      EL+ ++P  +A+  + DK +I+R+ +S++K          
Sbjct: 76  RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 125

Query: 83  PWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQE-GKFLY 141
             +LR  G   NTS  G+ +   PS L  +  + HL   IL++ DGF+F ++ E G+ +Y
Sbjct: 126 --SLRGTG---NTSTDGSYK---PSFLTDQELK-HL---ILEAADGFLFIVSCETGRVVY 173

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGM--KLPPGRGL-LSQGTA--ED 196
           +S++V+  L   Q E  GS+++D VHP D  ++ EQL        GR L L  GT   E 
Sbjct: 174 VSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEG 233

Query: 197 GASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHI 256
             SS      S           S      ++ R  F+R +       V      + V+H 
Sbjct: 234 QQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHC 293

Query: 257 TGRLR----LRVSLSHGRTVPSQIMGLVVVA----HALPPPTINEVRIDCH--MFVTRVN 306
           TG ++      VSL        Q     +VA         P   ++   C    F++R N
Sbjct: 294 TGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHN 353

Query: 307 MDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLN-KGQCVTKYYR 365
           ++    + ++R    +   P +++GK    F H ED + +R S   ++  KGQ ++  +R
Sbjct: 354 IEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFR 413

Query: 366 WMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTP 410
           +  KN  ++W+++S+    N  +   + II  N  + N   +  P
Sbjct: 414 FRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRP 458


>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
           sapiens]
          Length = 717

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 105/427 (24%), Positives = 186/427 (43%), Gaps = 73/427 (17%)

Query: 23  KEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDP 82
           +E   +  R RR K      EL+ ++P  +A+  + DK +I+R+ +S++K          
Sbjct: 65  RENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMK---------- 114

Query: 83  PWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQE-GKFLY 141
             ++R  G   N S  GA +   PS L     E  L   IL++ DGF+F +  E G+ +Y
Sbjct: 115 --SMRGTG---NKSTDGAYK---PSFLT----EQELKHLILEAADGFLFVVAAETGRVIY 162

Query: 142 ISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSA 201
           +S++V+  L   Q E  GS++++ VHP D  ++ EQL              T+E+  +  
Sbjct: 163 VSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLC-------------TSENSMTGR 209

Query: 202 SSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMK--------------STLTKR----- 242
               ++ T +     S   +   +   RSF  RM+              +T+ KR     
Sbjct: 210 ILDLKTGTVKKEGQQSSMRMCMGS--RRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGL 267

Query: 243 -GVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGL------VVVAHALPPPTINEVR 295
             V    + Y V+H TG ++       G T+P +   +       +VA      T + V 
Sbjct: 268 GPVKEGEAQYAVVHCTGYIKAWPPA--GMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVC 325

Query: 296 IDCH------MFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHS 349
           +D +       F++R N D  I + + R    +   P D++GK    F H ED   +R S
Sbjct: 326 MDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRES 385

Query: 350 HLDLLN-KGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKD 408
              ++  KGQ ++  YR+  KN  ++ I++S+    N  +   + II  N  +   + + 
Sbjct: 386 FQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQ 445

Query: 409 TPMDIAQ 415
             +++ Q
Sbjct: 446 AELEVHQ 452


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 92/433 (21%), Positives = 185/433 (42%), Gaps = 57/433 (13%)

Query: 9   QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
           + D  + +R+   + EK R      R + N    EL  +LP  A    ++DK+++++ +I
Sbjct: 28  EDDKDKAKRVSRNKSEKKR------RDQFNVLIKELGSMLPGNAR---KMDKSTVLQKSI 78

Query: 69  SYL-KMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLD 127
            +L K ++   Q D    +R +                P+ L+ E F   +    L++LD
Sbjct: 79  DFLRKHKEITAQSDAS-EIRQDW--------------KPTFLSNEEFTQLM----LEALD 119

Query: 128 GFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRG 187
           GF  A+  +G  +Y+SE+V+  L     +L   S+F+++  G+H E+ + L   L     
Sbjct: 120 GFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQSIFNFIPEGEHSEVYKILSTHLLESDS 179

Query: 188 LLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIK 247
           L  +                 T +P E +         T E   FI    +L      + 
Sbjct: 180 LTPEYLKSKNQLEFCCHMLRGTIDPKEPS---------TYEYVKFIGNFKSLNS----VS 226

Query: 248 SSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPP-----PTINEVRIDCHMFV 302
           SS +     T      +  +H  +   ++  +  V  A P       T+ E   +   F 
Sbjct: 227 SSAHNGFEGT------IQRTHRPSYEDRVCFVATVRLATPQFIKEMCTVEEPNEE---FT 277

Query: 303 TRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCVTK 362
           +R +++   ++ ++R    +   P +++G   Y + H +D+E +   H  L+  G+  + 
Sbjct: 278 SRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKCHEHLMQYGKGKSC 337

Query: 363 YYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYK-DTPMDIAQLPHLPE 421
           YYR++ K   +IW+Q+   I  +  N+  + I+  + ++S  E + +   ++     LPE
Sbjct: 338 YYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAERRRELGIEESLPE 397

Query: 422 KTSESSETSDSES 434
             ++ S+ S S++
Sbjct: 398 TAADKSQDSGSDN 410


>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
          Length = 719

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 60/184 (32%), Positives = 87/184 (47%), Gaps = 19/184 (10%)

Query: 14  RRERLQ----ALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTIS 69
           RR  LQ    A+  EKS  + R  R + N E   LA LLP P  I S+LDK S++RL++S
Sbjct: 18  RRRPLQKQRPAVGAEKSNPSKR-HRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVS 76

Query: 70  YLKMRDFAN--QGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLD 127
           YL+++ F    Q           P P  S   A            V E  L   +L+SL+
Sbjct: 77  YLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLA---------GSAVLEGRL---LLESLN 124

Query: 128 GFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRG 187
           GF   ++ EG   Y S T+  YLG  Q ++   +++DY+H  D  +   QL   + P + 
Sbjct: 125 GFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQV 184

Query: 188 LLSQ 191
           +  Q
Sbjct: 185 VFGQ 188


>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
          Length = 824

 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 94/483 (19%), Positives = 193/483 (39%), Gaps = 85/483 (17%)

Query: 11  DPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISY 70
           D   ++R +   + KS    + RR + N    EL+ +LP     T ++DK +++   I +
Sbjct: 2   DEDEKDRAKRASRNKSE---KKRRDQFNVLIKELSSMLP---GNTRKMDKTTVLEKVIGF 55

Query: 71  LKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFV 130
           L+  +  +                T +   Q+   PS L+ E F   +    L++LDGF+
Sbjct: 56  LQKHNEVSA--------------QTEICDIQQDWKPSFLSNEEFTQLM----LEALDGFI 97

Query: 131 FALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLS 190
            A+  +G  +Y+S++++  LG    ++   ++ +++   +H E+ + L            
Sbjct: 98  IAVTTDGSIIYVSDSITPLLGHLPSDVMDQNLLNFLPEQEHSEVYKIL------------ 145

Query: 191 QGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRM-KSTLTKRGVHIKSS 249
                       SS    T  P    SP  L +D+ LE  F+  + + +L  +    +  
Sbjct: 146 ------------SSHMLVTDSP----SPEYLKSDSDLE--FYCHLLRGSLNPK----EFP 183

Query: 250 GYKVIHITGRLR------------LRVSLSHGRTVP-SQIMGLVVVAHALPPPTINEVRI 296
            Y+ I   G  R               +LS    VP  + +  +       P  + E+ I
Sbjct: 184 TYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLATPQFLKEMCI 243

Query: 297 ---DCHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDL 353
                  F +R +++   ++ ++R    +   P +++G   Y + H +D+E +   H  L
Sbjct: 244 VDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHIDDLELLARCHQHL 303

Query: 354 LNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYK------ 407
           +  G+  +  YR++ K   +IW+Q+   I  +  N+  + I+  + ++S  + +      
Sbjct: 304 MQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTHSVVSYADVRVERRQE 363

Query: 408 ----DTPMDIAQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSED 463
               D P +      L +K S         +     SG+   +  S S    ++S ++  
Sbjct: 364 LALEDPPSEALHSSALKDKGSSLEPRQHFNTLDVGASGLNTSHSPSASSRSSHKSSHTAM 423

Query: 464 PEP 466
            EP
Sbjct: 424 SEP 426


>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
          Length = 802

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 107/465 (23%), Positives = 164/465 (35%), Gaps = 94/465 (20%)

Query: 26  SRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWN 85
           ++ A+++RR + N E   L +LLPL  A   +L    I+ L   Y +   F   G P   
Sbjct: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTP--- 61

Query: 86  LRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISET 145
             + GP   T +  AQ                    I+ +L GF+     EGK LY+SE+
Sbjct: 62  --LAGP---TGLLSAQELED----------------IVAALPGFLLVFTAEGKLLYLSES 100

Query: 146 VSIYLGLSQVELT--GSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASS 203
           VS +LG S V+L   G S++D + P DH+ + +QL                         
Sbjct: 101 VSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL------------------------- 135

Query: 204 SSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLR 263
                       T PS L TD    R F  R     T + +  +S+G K++ I GR    
Sbjct: 136 ------------TLPSALDTD----RLFRCRFN---TSKSLRRQSAGNKLVLIRGRFHAH 176

Query: 264 VSLSHGRTVP---SQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISD 320
              ++    P   +    L       P P      +   MF +R   DL ++     +  
Sbjct: 177 PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLI 236

Query: 321 YMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV--TKYYRWMQKNGGYIWIQS 378
           Y+     +++ K  Y  +H ED+      H  LL +   +      R   K GG+ WI  
Sbjct: 237 YLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI-- 294

Query: 379 SATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDI--------------AQLPHLPEKTS 424
                +      E  I   NY +S+ E       +                LP  PE   
Sbjct: 295 ---YCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENIL 351

Query: 425 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRK 469
              E S +        G         + E    S + E P P ++
Sbjct: 352 SQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKE 396


>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
          Length = 1399

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 16/152 (10%)

Query: 31  RSRRGKENFEFYELAKLLPLPAAITSQL----DKASIIRLTISYLKMRDFANQGDPPWNL 86
           + RR +EN    ELA+LL    +    L    DK  I++ T+  +++     Q     + 
Sbjct: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92

Query: 87  RMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETV 146
            ++    ++S +G   + S            LG  +L++LDGF F +N EG+ +++SE V
Sbjct: 93  DVQKSDISSSSQGVIEKES------------LGPLLLEALDGFFFVVNCEGRIVFVSENV 140

Query: 147 SIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178
           + YLG +Q EL  +SV+  +H GDH E  + L
Sbjct: 141 TSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172


>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
          Length = 1440

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 16/152 (10%)

Query: 31  RSRRGKENFEFYELAKLLPLPAAITSQL----DKASIIRLTISYLKMRDFANQGDPPWNL 86
           + RR +EN    ELA+LL    +    L    DK  I++ T+  +++     Q     + 
Sbjct: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92

Query: 87  RMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETV 146
            ++    ++S +G   + S            LG  +L++LDGF F +N EG+ +++SE V
Sbjct: 93  DVQKSDISSSSQGVIEKES------------LGPLLLEALDGFFFVVNCEGRIVFVSENV 140

Query: 147 SIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178
           + YLG +Q EL  +SV+  +H GDH E  + L
Sbjct: 141 TSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172


>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
          Length = 1441

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 46/152 (30%), Positives = 77/152 (50%), Gaps = 16/152 (10%)

Query: 31  RSRRGKENFEFYELAKLLPLPAAITSQL----DKASIIRLTISYLKMRDFANQGDPPWNL 86
           + RR +EN    ELA+LL    +    L    DK  I++ T+  +++     Q     + 
Sbjct: 33  KRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDD 92

Query: 87  RMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISETV 146
            ++    ++S +G   + S            LG  +L++LDGF F +N EG+ +++SE V
Sbjct: 93  DVQKSDISSSSQGVIEKES------------LGPLLLEALDGFFFVVNCEGRIVFVSENV 140

Query: 147 SIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178
           + YLG +Q EL  +SV+  +H GDH E  + L
Sbjct: 141 TSYLGYNQEELMNTSVYSILHVGDHAEFVKNL 172


>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 55/171 (32%), Positives = 93/171 (54%), Gaps = 26/171 (15%)

Query: 9   QQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTI 68
           +Q  + +ERL    +E   +  R RR K      EL+ ++P  +A+  + DK +I+R+ +
Sbjct: 80  EQSSADKERLA---RENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAV 136

Query: 69  SYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDG 128
           S++K            +LR  G   NTS  G+ +   PS L  +  + HL   IL++ DG
Sbjct: 137 SHMK------------SLRGTG---NTSTDGSYK---PSFLTDQELK-HL---ILEAADG 174

Query: 129 FVFALNQE-GKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQL 178
           F+F ++ E G+ +Y+S++V+  L   Q E  GS+++D VHP D  ++ EQL
Sbjct: 175 FLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQL 225


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 75/337 (22%), Positives = 129/337 (38%), Gaps = 11/337 (3%)

Query: 423  TSESSETSDS-ESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 481
            +SESS++SDS +SDS D+S     N NS   +  N S++S+          +   N  + 
Sbjct: 698  SSESSDSSDSSDSDSSDSSD--SSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS 755

Query: 482  NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 541
            +D   SS++ DS DS DS + SD  N     D   +  +          + SD    + +
Sbjct: 756  SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSD-SSDSSD 814

Query: 542  SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGG-SASRRRLSSASSPGGLDAGLVE 600
            S  SDS+  SDS+  + +  SS             G  S S  R  S++S    D+    
Sbjct: 815  SSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874

Query: 601  PPRLLSSPNSASVLKIKTEISEPIN-FDNDSSIWNYPPNREISRN-----ESPYSMTKPP 654
                 S  + ++     ++ S+  N  D+DSS  +   +   S N     ES  S     
Sbjct: 875  NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN 934

Query: 655  SSEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDP 714
            SS+   S                   DS  +   +D  ++  +    S+ ++ +  +SD 
Sbjct: 935  SSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDS 994

Query: 715  LSPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNS 751
                 S++  D    +          +     S+++S
Sbjct: 995  SDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSS 1031



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 62/250 (24%), Positives = 103/250 (41%), Gaps = 6/250 (2%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S+SS++SDS SDS D+S  ++ +++S S +  + S++S+  +       +   N  + +
Sbjct: 1039 SSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSS 1097

Query: 483  DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            D   SS + DS DS DS + SD  N     D   +  +            SD    +  S
Sbjct: 1098 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS---SDSSDSSESSDSS 1154

Query: 543  LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPP 602
             +SDS+  SDS+  + +  SS                +S    SS SS     +   +  
Sbjct: 1155 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214

Query: 603  RLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPSP 662
               SS +S S     +  S   +  +DSS  +   N   S + S  S +   S++   S 
Sbjct: 1215 D--SSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQ 1272

Query: 663  QGGGGGGGGG 672
               G G   G
Sbjct: 1273 SKSGNGNNNG 1282



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 11/169 (6%)

Query: 423 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPE-PDRKKSGNACDNDMNC 481
           +S+SS++SDS+SDS  +   + D+++       N S++S++ +  D   S N+ D+  + 
Sbjct: 613 SSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSS-DS 671

Query: 482 NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 541
           +D   SSS+ DS +S DS + SD  N     D   +  +         +S       N  
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS---------DSSDSSDSSNSN 722

Query: 542 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
           S  SDS+  SDS+  + +  SS                +S    SS SS
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 55/221 (24%), Positives = 96/221 (43%), Gaps = 19/221 (8%)

Query: 425 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDD 484
           +S  TSD+ +   + +G   +++N KSD    +S++S+    D   S ++ D+  + + D
Sbjct: 514 DSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD 573

Query: 485 GHSSSNPDSRDSD----------DSFEHSDFENPKAGEDGFGALGAMQIKVE----RYVE 530
            +SSS+ DS DSD          DS   SD  +     D   +  +   K +        
Sbjct: 574 SNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDS 633

Query: 531 SESDLRLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
           S+SD +  + +S +SDS+ +SDS+  + +  SS                +S    SS SS
Sbjct: 634 SDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSS 693

Query: 591 PGGLDAGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSS 631
                +   +     SS +S S     ++ S   + D+DSS
Sbjct: 694 DSSNSSESSD-----SSDSSDSDSSDSSDSSNSNSSDSDSS 729



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 70/336 (20%), Positives = 132/336 (39%), Gaps = 18/336 (5%)

Query: 424 SESSETSDSES-------DSKDTSGITEDNENS-KSDEKGNQSENSEDPEPDRKKSGNAC 475
           S+SS++SDS+S       DS D+S  ++ +++S  SD K + S++  D      KS ++ 
Sbjct: 585 SDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD 644

Query: 476 DNDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDL 535
            N  + +D+  SS + +S +S DS + SD  +  +  D   +  +            SD 
Sbjct: 645 SNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSD- 703

Query: 536 RLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLD 595
              + +S  SDS+  SDS+    + + S +             S S    +S+ S    D
Sbjct: 704 ---SSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 760

Query: 596 AGLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPS 655
           +         SS +S S     +  S   N  ++SS  +   N   S N S  S +   S
Sbjct: 761 SSNSSD----SSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSS 816

Query: 656 SEHFPSPQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPL 715
                +              + +  DS  +   +DG+ +  +    S+ ++ +  +SD  
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSS--DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS 874

Query: 716 SPPLSASPRDKHPGNGGGGGGGGGGAGGGGPSASNS 751
           +   S+   D +  +          +     S S++
Sbjct: 875 NSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSN 910



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 68/326 (20%), Positives = 117/326 (35%), Gaps = 4/326 (1%)

Query: 424  SESSETSDSE--SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 481
            S SS++SDS   SDS D+S  ++ +++S S    + S++S+  +       +   +  N 
Sbjct: 971  SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030

Query: 482  NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 541
            +D   SS + DS DS DS + SD  N     D   +  +            S+    +  
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS 1090

Query: 542  SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEP 601
            S +SDS+  SDS+  + +  SS                +S    SS SS     +   E 
Sbjct: 1091 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES 1150

Query: 602  PRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSSEHFPS 661
                 S +S+             + D+ +S  +   +     ++S  S     SS+   S
Sbjct: 1151 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1210

Query: 662  PQGGGGGGGGGGGLHVAIPDSVLTPPGADGAAARKTQFGASATAALAPVASDPLSPPLSA 721
                               DS  +   +D  ++  +    S+ ++ +  +SD  S     
Sbjct: 1211 SDSSDSSDSSDSSDSSDSSDSNESSDSSD--SSDSSDSSNSSDSSDSSDSSDSTSDSNDE 1268

Query: 722  SPRDKHPGNGGGGGGGGGGAGGGGPS 747
            S      GNG   G        G  S
Sbjct: 1269 SDSQSKSGNGNNNGSDSDSDSEGSDS 1294



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 46/171 (26%), Positives = 74/171 (43%), Gaps = 3/171 (1%)

Query: 423  TSESSETSDSES-DSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 481
            +S+SS +SDS+S DS ++S  ++ + +S S E  N S+NS   +       +   +  N 
Sbjct: 894  SSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953

Query: 482  NDDGHSSSNPDSRDSDD--SFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQN 539
            +D  +SS + +S DS D  S + SD  N     D   +  +            SD    +
Sbjct: 954  SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013

Query: 540  CESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
              S +SDS+  SDS+  + +  SS                +S    SS SS
Sbjct: 1014 DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1064



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 46/170 (27%), Positives = 75/170 (44%), Gaps = 3/170 (1%)

Query: 423  TSESSETSDSE--SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN 480
            +SESS +SD+   SDS ++S  ++ +++S S +  N S++S   +     S ++ D+  N
Sbjct: 923  SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSS-N 981

Query: 481  CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 540
             +D   SS + DS DS DS   SD  +     D   +  +            SD    + 
Sbjct: 982  SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 541  ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
             S +SDS+  SDS+  + +  SS                +S    SS SS
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS 1091



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 43/168 (25%), Positives = 77/168 (45%), Gaps = 1/168 (0%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S+SS++SDS SDS D+S  ++ +++S S +  N S++S   +       +   +  + +
Sbjct: 985  SSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSS 1043

Query: 483  DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            D   SS + DS +S DS + SD  +     D   +  + +        + SD    +  S
Sbjct: 1044 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103

Query: 543  LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
             +SDS+  SDS+  + +  SS               ++S    SS SS
Sbjct: 1104 DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESS 1151



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 46/175 (26%), Positives = 79/175 (45%), Gaps = 7/175 (4%)

Query: 423  TSESSETSDSE--SDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDND-- 478
            +S++S +SDS   SDS D+S  +  +++S S +  N S++S+    D   S N+ D+   
Sbjct: 929  SSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDS 988

Query: 479  ---MNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDL 535
                + +D   SS++ DS DS DS + S+  +     D   +  +            SD 
Sbjct: 989  SDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDS 1048

Query: 536  RLQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
               +  S +SDS+  SDS+  + +  SS      +        ++S    SS SS
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 45/170 (26%), Positives = 76/170 (44%), Gaps = 3/170 (1%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S SS++SDS S+S D+S  +  ++NS S +  N S++S+  +       +   +  N +
Sbjct: 908  SSNSSDSSDS-SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966

Query: 483  D--DGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 540
            D  D +SS + DS +S DS + SD  +     D   +  +          + SD    + 
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026

Query: 541  ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
             S +SDS+  SDS+  + +  SS                +S    SS SS
Sbjct: 1027 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1076



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 43/168 (25%), Positives = 74/168 (44%), Gaps = 1/168 (0%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S+SS +SDS SDS D+S  +  +++S S +  N S++S+  +       +   +  + +
Sbjct: 997  SSDSSNSSDS-SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1055

Query: 483  DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            +   SS + DS DS DS + SD  +     D   +  +            SD    +  S
Sbjct: 1056 NSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1115

Query: 543  LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
             +SDS+  SDS+  + +  SS            +   +S    SS SS
Sbjct: 1116 DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSS 1163



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 40/168 (23%), Positives = 73/168 (43%), Gaps = 2/168 (1%)

Query: 423 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
           +S+S  +  S+SDS D+S  ++ +++S S +  + S++S+      K   ++ D+D    
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSK-- 639

Query: 483 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            D   S++ DS D+ DS + S+  N     D   +  +            SD    +  S
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS 699

Query: 543 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
            +SDS+  SDS     + +S+ +              +S    SS SS
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 43/170 (25%), Positives = 73/170 (42%), Gaps = 5/170 (2%)

Query: 423 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
           +S+SS++SDS S+S ++S  ++ +++  SD   + + NS D +       +   N  + +
Sbjct: 686 SSDSSDSSDS-SNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744

Query: 483 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
           D   SS++ DS DS DS   SD  +     D   +  +            SD    +  S
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSS 804

Query: 543 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPG 592
            +SDS+  SDS+    + +S                S+     SS SS G
Sbjct: 805 NSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD----SSDSSDG 850



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 44/160 (27%), Positives = 80/160 (50%), Gaps = 4/160 (2%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEP-DRKKSGNACDNDMNC 481
            +S+SS++SDS S+S D+S  +E +++S S +  + S++S+  +  D   S N+ D+  + 
Sbjct: 1129 SSDSSDSSDS-SNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS-DS 1186

Query: 482  NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 541
            +D   SS + DS DS DS + SD  +     D   +  +            SD    +  
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246

Query: 542  SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSAS 581
            S +SDS+  SDS+ ++ + ++ +   + K       GS S
Sbjct: 1247 SNSSDSSDSSDSS-DSTSDSNDESDSQSKSGNGNNNGSDS 1285



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 39/141 (27%), Positives = 71/141 (50%), Gaps = 3/141 (2%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S+SS++SDS SDS D+S  ++ +++S S +  + S++S+  +       +   +  + +
Sbjct: 1162 SSDSSDSSDS-SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1220

Query: 483  DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            D   SS + DS +S DS + SD  +     D   +  +     +   ES+S  +  N  +
Sbjct: 1221 DSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN 1280

Query: 543  LTSDSAKDSDSAGEAGAQASS 563
              SDS  DSDS G     ++S
Sbjct: 1281 NGSDS--DSDSEGSDSNHSTS 1299



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 43/168 (25%), Positives = 72/168 (42%), Gaps = 1/168 (0%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S SS++SDS SDS D+S  ++ + +S S    + S++S+  +       +   +  N +
Sbjct: 1000 SSNSSDSSDS-SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1058

Query: 483  DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            D   SS + DS DS DS + SD        D   +  +            SD    +  S
Sbjct: 1059 DSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSS 1118

Query: 543  LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
             +S+S+  SDS+  + +  SS         +      +S    SS SS
Sbjct: 1119 DSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSS 1166



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 42/169 (24%), Positives = 74/169 (43%), Gaps = 1/169 (0%)

Query: 423  TSESSETSDSES-DSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNC 481
            +S SS++SDS S DS D+S  ++ +++S S +  + S++S   +       +   N  + 
Sbjct: 962  SSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDS 1021

Query: 482  NDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 541
            ++   SS++ DS DS DS + SD  +     D   +  +            SD    +  
Sbjct: 1022 SNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1081

Query: 542  SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
            S +SDS+  S+S+  + +  SS                +S    SS SS
Sbjct: 1082 SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1130



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 56/234 (23%), Positives = 95/234 (40%), Gaps = 23/234 (9%)

Query: 423 TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
           +S+SS++SDS SDS  +S  +  +++S S +  N SE+S+  +     S ++ D+  + +
Sbjct: 665 SSDSSDSSDS-SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNS 723

Query: 483 DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCES 542
            D  SS++ DS DS +S + SD  +     D                   SD    +  S
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS------------------SDSSDSSNSS 765

Query: 543 LTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEPP 602
            +SDS+  SDS+  + +  S+                +S    SS SS    D+   +  
Sbjct: 766 DSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSS----DSSDSDSS 821

Query: 603 RLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYSMTKPPSS 656
               S NS+             + D+     +   NR  S N S  S +   S+
Sbjct: 822 NSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN 875



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 41/171 (23%), Positives = 73/171 (42%), Gaps = 2/171 (1%)

Query: 422 KTSESSETSDSESDSKD--TSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDM 479
           K+   S  SDS+SDS D  +S  ++++++S S    N S++S+  +     S +   N  
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687

Query: 480 NCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQN 539
           + +D   SS++ +S DS DS +    ++  +         +          + SD    +
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747

Query: 540 CESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASS 590
             S +SDS+  SDS+  + +  SS                +S    SS SS
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSS 798



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 41/175 (23%), Positives = 72/175 (41%), Gaps = 18/175 (10%)

Query: 421 EKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMN 480
           +++ ++   SDS+    D S  T D  NS S+  GN   +  D     K   ++ D+D +
Sbjct: 496 DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSS 555

Query: 481 CNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNC 540
            + +   SS+    DS DS   SD ++  +                    S+SD    + 
Sbjct: 556 DSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSD---------------SSDSD---SSD 597

Query: 541 ESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLD 595
            S +SDS+  SDS+  + +  SS  +    + +     S S+   S ++S    D
Sbjct: 598 SSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 46/194 (23%), Positives = 88/194 (45%), Gaps = 9/194 (4%)

Query: 378 SSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDIAQLPHLPEKTSESSETSDSESDSK 437
           S ++ + N+ ++N+ +    +   SN        D +      +  S +S  S + SDS 
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSS 833

Query: 438 DTSGITEDNENSKS-----DEKGNQSENSEDPE-PDRKKSGNACD--NDMNCNDDGHSSS 489
           D+S  ++ +++S S      +  N+S++S   +  D   S N+ D  +  + N+  +SS 
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSD 893

Query: 490 NPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCESLTSDSAK 549
           + DS +S DS + SD  N     D   +  + +        + SD    +  S +SDS+ 
Sbjct: 894 SSDSSNSSDS-DSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN 952

Query: 550 DSDSAGEAGAQASS 563
            SDS+  + +  SS
Sbjct: 953 SSDSSNSSDSSNSS 966



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 58/233 (24%), Positives = 93/233 (39%), Gaps = 15/233 (6%)

Query: 422 KTSESSETSDSESDSKDTSGITE-----DNENSKSDEKGNQSENSEDPEPDRKKSGNACD 476
           K   S+  SDS SD  D+    +     D+ NS  +  GN   NSE  + +    G+A  
Sbjct: 435 KVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSES-DNNSSSRGDASY 493

Query: 477 NDMNCNDDGHSSSNPDSRDSDDSFEHSDFENPKAGEDGFGALGAMQIKVERYVESESDLR 536
           N     D+G+ S +  + D DDS   SD  N  +  +G G  G          + +SD  
Sbjct: 494 NSDESKDNGNGSDSKGAED-DDSDSTSDTNN--SDSNGNGNNGNDDNDKSDSGKGKSD-- 548

Query: 537 LQNCESLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDA 596
             + +S +SDS+  SDS+  + + +S  +              +S     S+ S    D+
Sbjct: 549 --SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS--DSSDSSNSSDS 604

Query: 597 GLVEPPRLLSSPNSASVLKIKTEISEPINFDNDSSIWNYPPNREISRNESPYS 649
                    S  + +S  K  +  SE  + D+DS   +   N   S + S  S
Sbjct: 605 SDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS 657



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 24/75 (32%), Positives = 42/75 (56%), Gaps = 1/75 (1%)

Query: 423  TSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCN 482
            +S+S+E+SDS SDS D+S  +  +++S S +  + + +S D    + KSGN  +N  + +
Sbjct: 1228 SSDSNESSDS-SDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSD 1286

Query: 483  DDGHSSSNPDSRDSD 497
             D   S +  S   D
Sbjct: 1287 SDSEGSDSNHSTSDD 1301



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 40/209 (19%), Positives = 82/209 (39%), Gaps = 8/209 (3%)

Query: 425 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRKKSGNACDNDMNCNDD 484
           +   +SD  + + D +  +++N +S+ D   N  E+ ++      K     D+D + +D 
Sbjct: 463 DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSD-STSDT 521

Query: 485 GHSSSNPDSRDSDDSFEHSDF---ENPKAGEDGFGALGAMQIKVERYVESESDLRLQNCE 541
            +S SN +  + +D  + SD    ++  +  D   +  +         +S       + +
Sbjct: 522 NNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSD 581

Query: 542 SLTSDSAKDSDSAGEAGAQASSKHQKRKKRRKRQKGGSASRRRLSSASSPGGLDAGLVEP 601
           S  SDS+  SDS     + +S                S+  +  SS S     D+     
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS----D 637

Query: 602 PRLLSSPNSASVLKIKTEISEPINFDNDS 630
            +  SS +++S     ++ S+  N  N S
Sbjct: 638 SKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666



 Score = 33.5 bits (75), Expect = 0.91
 Identities = 26/108 (24%), Positives = 47/108 (43%), Gaps = 14/108 (12%)

Query: 421 EKTSESSETSDSESDSKDTSGITEDN--ENSKSDEKGNQSENSEDP---EPDRKKSGNAC 475
           E T + +   +   +++ T G  ED   +NS     GN ++  ED    + + +++GN  
Sbjct: 212 EITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDEEAGNGK 271

Query: 476 DNDMNCN---------DDGHSSSNPDSRDSDDSFEHSDFENPKAGEDG 514
           D+  N           +D H SS   + DS + ++    E+P    DG
Sbjct: 272 DSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDG 319


>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
          Length = 1464

 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 80/398 (20%), Positives = 150/398 (37%), Gaps = 49/398 (12%)

Query: 6   PSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQL----DKA 61
           PS  +   R+E    L     R+  +  R +EN    ELA+L+              DK 
Sbjct: 11  PSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKC 70

Query: 62  SIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSH 121
           +I++ T+  ++             ++ +      ++   Q+    S     + +  LG  
Sbjct: 71  AILKETVKQIRQ------------IKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPM 118

Query: 122 ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 181
           +L++LDGF F +N EG  +++SE V+ YL  +Q EL   SV+  +H GDH E  + L   
Sbjct: 119 MLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNL--- 175

Query: 182 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 241
           LP         + E    ++ + +     +P+  +       DN      +  M+     
Sbjct: 176 LPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEE--GHDNQEAHQKYETMQCFAVS 233

Query: 242 RGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMF 301
           +   IK  G  +      +  RV +     +PS                          F
Sbjct: 234 QPKSIKEEGEDLQSCLICVARRVPMKERPVLPSS-----------------------ESF 270

Query: 302 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHA----EDVEGIRHSHLDLLNKG 357
            TR ++   I   +            + + +RC    HA    E V   +  H ++L +G
Sbjct: 271 TTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQG 330

Query: 358 QCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNII 395
              ++ YR+   +G  +  Q+ + + I ++  NE  ++
Sbjct: 331 LAFSQIYRFSLSDGTLVAAQTKSKL-IRSQTTNEPQLV 367


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.130    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,754,591
Number of Sequences: 37866
Number of extensions: 2054382
Number of successful extensions: 33672
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 440
Number of HSP's successfully gapped in prelim test: 677
Number of HSP's that attempted gapping in prelim test: 17173
Number of HSP's gapped (non-prelim): 9360
length of query: 901
length of database: 18,247,518
effective HSP length: 111
effective length of query: 790
effective length of database: 14,044,392
effective search space: 11095069680
effective search space used: 11095069680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.