Search of human proteins with 22024390

Search of human proteins with 22024390

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22024390 potassium voltage-gated channel, subfamily H,
member 5 isoform 1 [Homo sapiens]
         (988 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22024390 potassium voltage-gated channel, subfamily H, member...  1986   0.0  
gi|4504831 potassium voltage-gated channel, subfamily H, member ...  1453   0.0  
gi|27437001 potassium voltage-gated channel, subfamily H, member...  1439   0.0  
gi|27886648 potassium voltage-gated channel, subfamily H, member...  1247   0.0  
gi|27886646 potassium voltage-gated channel, subfamily H, member...  1231   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   538   e-153
gi|27886667 potassium voltage-gated channel, subfamily H, member...   526   e-149
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   502   e-142
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   491   e-138
gi|27886653 potassium voltage-gated channel, subfamily H, member...   470   e-132
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   463   e-130
gi|26051273 voltage-gated potassium channel, subfamily H, member...   461   e-129
gi|27886651 potassium voltage-gated channel, subfamily H, member...   456   e-128
gi|26051271 voltage-gated potassium channel, subfamily H, member...   414   e-115
gi|27886665 potassium voltage-gated channel, subfamily H, member...   327   3e-89
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   176   1e-43
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   170   7e-42
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   168   3e-41
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   164   4e-40
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    152   1e-36
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   150   6e-36
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   150   6e-36
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   144   4e-34
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   144   4e-34
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    132   1e-30
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   108   2e-23
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    107   4e-23
gi|205361107 potassium channel, subfamily K, member 17 isoform 2...    45   3e-04
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ...    45   3e-04
gi|14589851 potassium channel, subfamily K, member 2 isoform b [...    44   6e-04

>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score = 1986 bits (5145), Expect = 0.0
 Identities = 988/988 (100%), Positives = 988/988 (100%)

Query: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60
           MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ
Sbjct: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60

Query: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120
           KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK
Sbjct: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120

Query: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR 180
           VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR
Sbjct: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR 180

Query: 181 LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT 240
           LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT
Sbjct: 181 LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT 240

Query: 241 KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC 300
           KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC
Sbjct: 241 KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC 300

Query: 301 LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA 360
           LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA
Sbjct: 301 LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA 360

Query: 361 HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV 420
           HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV
Sbjct: 361 HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV 420

Query: 421 SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR 480
           SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR
Sbjct: 421 SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR 480

Query: 481 YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL 540
           YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL
Sbjct: 481 YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL 540

Query: 541 NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD 600
           NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD
Sbjct: 541 NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD 600

Query: 601 DEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSF 660
           DEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSF
Sbjct: 601 DEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSF 660

Query: 661 SRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELR 720
           SRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELR
Sbjct: 661 SRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELR 720

Query: 721 NQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRD 780
           NQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRD
Sbjct: 721 NQGSTQGDPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRD 780

Query: 781 AMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLL 840
           AMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLL
Sbjct: 781 AMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLL 840

Query: 841 SEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYP 900
           SEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYP
Sbjct: 841 SEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYP 900

Query: 901 IPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQ 960
           IPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQ
Sbjct: 901 IPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQ 960

Query: 961 VPPQIPCQDIFSVSRPESPESDKDEIHF 988
           VPPQIPCQDIFSVSRPESPESDKDEIHF
Sbjct: 961 VPPQIPCQDIFSVSRPESPESDKDEIHF 988


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score = 1453 bits (3762), Expect = 0.0
 Identities = 734/995 (73%), Positives = 828/995 (83%), Gaps = 51/995 (5%)

Query: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60
           M GG+RGLVAPQNTFLENIVRRS++++F+LGNAQIVDWP+VYSNDGFCKLSGYHRA+VMQ
Sbjct: 3   MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQ 62

Query: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120
           KSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE +K
Sbjct: 63  KSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDK 122

Query: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHKHS 179
           VVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHKHS
Sbjct: 123 VVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHS 182

Query: 180 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK 239
           RLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVSFK
Sbjct: 183 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFK 242

Query: 240 TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299
           T+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDLLS
Sbjct: 243 TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLS 302

Query: 300 CLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLV 359
           CLPYD+INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY+EYGAAVLVLLVCVFGL 
Sbjct: 303 CLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLA 362

Query: 360 AHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS-AGIWEGGPSKDSL 418
           AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQLA+ IGTPY++N S +G WEGGPSK+S+
Sbjct: 363 AHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSV 422

Query: 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 478
           Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA+MM+GSLLYATIFGNVTTIFQQMYANT
Sbjct: 423 YISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANT 482

Query: 479 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 538
           NRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVSTWSMS+GIDTEKVL ICPKDMRADICV
Sbjct: 483 NRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICV 542

Query: 539 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 598
           HLNRKVF EHPAFRLASDGCLRALA+EFQT+HCAPGDLIYHAGESVD+LCFVVSGSLEVI
Sbjct: 543 HLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI 602

Query: 599 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658
           QDDEVVAILGKGDVFGD+FWKE TLA +CANVRALTYCDLH+IKR+AL KVL+FYTAF++
Sbjct: 603 QDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSH 662

Query: 659 SFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKE 718
           SFSRNL LT NLRKRI+FRKISDVK+EEEER+++KNE  L +P DHPVR+LFQ+F+QQKE
Sbjct: 663 SFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKE 722

Query: 719 LRNQGSTQG------DPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTS- 771
            R      G      D E+  +  E  S  +  S+   SVVTV +      S     TS 
Sbjct: 723 ARLAAERGGRDLDDLDVEKGNVLTEHASANH--SLVKASVVTVRESPATPVSFQAASTSG 780

Query: 772 --ESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWN 829
             +  K     +  L P GG    C K            K W R K+  G    K EDWN
Sbjct: 781 VPDHAKLQAPGSECLGPKGGGGD-CAK-----------RKSWARFKDACG----KSEDWN 824

Query: 830 NVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSP 889
            V+KAESM  L E  K+S          L+KTDSCDSGITKSDLRLD  GEARSP + SP
Sbjct: 825 KVSKAESMETLPERTKASGEAT------LKKTDSCDSGITKSDLRLDNVGEARSPQDRSP 878

Query: 890 IQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQ 949
           I A+ KH FYPIPEQ LQ T+ EV+HELKEDI+ L+ +MT +EKQ++EIL+IL+      
Sbjct: 879 ILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILT------ 932

Query: 950 ASSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKD 984
            S   SQ P         Q++F +SRP+SPES++D
Sbjct: 933 -SRRSSQSP---------QELFEISRPQSPESERD 957


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score = 1439 bits (3724), Expect = 0.0
 Identities = 734/1022 (71%), Positives = 828/1022 (81%), Gaps = 78/1022 (7%)

Query: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60
           M GG+RGLVAPQNTFLENIVRRS++++F+LGNAQIVDWP+VYSNDGFCKLSGYHRA+VMQ
Sbjct: 3   MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQ 62

Query: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120
           KSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE +K
Sbjct: 63  KSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDK 122

Query: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHKHS 179
           VVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHKHS
Sbjct: 123 VVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHS 182

Query: 180 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK 239
           RLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVSFK
Sbjct: 183 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFK 242

Query: 240 TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299
           T+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDLLS
Sbjct: 243 TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLS 302

Query: 300 CLPYDIINAFENVDE---------------------------GISSLFSSLKVVRLLRLG 332
           CLPYD+INAFENVDE                           GISSLFSSLKVVRLLRLG
Sbjct: 303 CLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLG 362

Query: 333 RVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 392
           RVARKLDHY+EYGAAVLVLLVCVFGL AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQL
Sbjct: 363 RVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 422

Query: 393 ALSIGTPYRYNTS-AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVA 451
           A+ IGTPY++N S +G WEGGPSK+S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA
Sbjct: 423 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 482

Query: 452 MMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVS 511
           +MM+GSLLYATIFGNVTTIFQQMYANTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVS
Sbjct: 483 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 542

Query: 512 TWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHC 571
           TWSMS+GIDTEKVL ICPKDMRADICVHLNRKVF EHPAFRLASDGCLRALA+EFQT+HC
Sbjct: 543 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 602

Query: 572 APGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVR 631
           APGDLIYHAGESVD+LCFVVSGSLEVIQDDEVVAILGKGDVFGD+FWKE TLA +CANVR
Sbjct: 603 APGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVR 662

Query: 632 ALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLR 691
           ALTYCDLH+IKR+AL KVL+FYTAF++SFSRNL LT NLRKRI+FRKISDVK+EEEER++
Sbjct: 663 ALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMK 722

Query: 692 QKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQG------DPERNQLQVESRSLQNGA 745
           +KNE  L +P DHPVR+LFQ+F+QQKE R      G      D E+  +  E  S  +  
Sbjct: 723 RKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH-- 780

Query: 746 SITGTSVVTVSQITPIQTSLAYVKTS---ESLKQNNRDAMELKPNGGADQKCLKVNSPIR 802
           S+   SVVTV +      S     TS   +  K     +  L P GG    C K      
Sbjct: 781 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGD-CAK------ 833

Query: 803 MKNGNGKGWLRLKNNMGAHEEKKEDWNNVTKAESMGLLSEDPKSSDSENSVTKNPLRKTD 862
                 K W R K+  G    K EDWN V+KAESM  L E  K+S          L+KTD
Sbjct: 834 -----RKSWARFKDACG----KSEDWNKVSKAESMETLPERTKASGEAT------LKKTD 878

Query: 863 SCDSGITKSDLRLDKAGEARSPLEHSPIQADAKHPFYPIPEQALQTTLQEVKHELKEDIQ 922
           SCDSGITKSDLRLD  GEARSP + SPI A+ KH FYPIPEQ LQ T+ EV+HELKEDI+
Sbjct: 879 SCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIK 938

Query: 923 LLSCRMTALEKQVAEILKILSEKSVPQASSPKSQMPLQVPPQIPCQDIFSVSRPESPESD 982
            L+ +MT +EKQ++EIL+IL+       S   SQ P         Q++F +SRP+SPES+
Sbjct: 939 ALNAKMTNIEKQLSEILRILT-------SRRSSQSP---------QELFEISRPQSPESE 982

Query: 983 KD 984
           +D
Sbjct: 983 RD 984


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score = 1247 bits (3227), Expect = 0.0
 Identities = 615/615 (100%), Positives = 615/615 (100%)

Query: 59  MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118
           MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 119 EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 178
           EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH
Sbjct: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKH 120

Query: 179 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 238
           SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF
Sbjct: 121 SRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSF 180

Query: 239 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 298
           KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL
Sbjct: 181 KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLL 240

Query: 299 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 358
           SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL
Sbjct: 241 SCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGL 300

Query: 359 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 418
           VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL
Sbjct: 301 VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSL 360

Query: 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 478
           YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT
Sbjct: 361 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 420

Query: 479 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 538
           NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV
Sbjct: 421 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 480

Query: 539 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 598
           HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI
Sbjct: 481 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 540

Query: 599 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658
           QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN
Sbjct: 541 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 600

Query: 659 SFSRNLTLTCNLRKR 673
           SFSRNLTLTCNLRKR
Sbjct: 601 SFSRNLTLTCNLRKR 615


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score = 1231 bits (3184), Expect = 0.0
 Identities = 607/607 (100%), Positives = 607/607 (100%)

Query: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60
           MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ
Sbjct: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60

Query: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120
           KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK
Sbjct: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120

Query: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR 180
           VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR
Sbjct: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHSR 180

Query: 181 LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT 240
           LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT
Sbjct: 181 LAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKT 240

Query: 241 KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC 300
           KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC
Sbjct: 241 KQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSC 300

Query: 301 LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA 360
           LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA
Sbjct: 301 LPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVA 360

Query: 361 HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV 420
           HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV
Sbjct: 361 HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYV 420

Query: 421 SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR 480
           SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR
Sbjct: 421 SSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNR 480

Query: 481 YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL 540
           YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL
Sbjct: 481 YHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHL 540

Query: 541 NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD 600
           NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD
Sbjct: 541 NRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQD 600

Query: 601 DEVVAIL 607
           DEVVAIL
Sbjct: 601 DEVVAIL 607


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  538 bits (1387), Expect = e-153
 Identities = 286/722 (39%), Positives = 426/722 (59%), Gaps = 65/722 (9%)

Query: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
           +RG VAPQNT+L+ I+R+    S  FL+ NAQ+ +  ++Y NDGFC+L GY R +VMQ+ 
Sbjct: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE   V+
Sbjct: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123

Query: 123 LFLCTFKDITLFKQPIEDDS---------------------------------------- 142
           +F+  F+D+          S                                        
Sbjct: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183

Query: 143 -TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYKQEAP 200
            T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK +AP
Sbjct: 184 FTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAP 242

Query: 201 KTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA-----------WLV 249
           +     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +             V
Sbjct: 243 RIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTV 302

Query: 250 LDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAF 309
           +D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  F
Sbjct: 303 VDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-IF 361

Query: 310 ENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYS 369
               +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+
Sbjct: 362 RTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYA 421

Query: 370 IGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTS 429
           IG+ E    + + I    WL  L + +G  Y  +  A     GPS    YV++LYFT +S
Sbjct: 422 IGNVER-PYLEHKI---GWLDSLGVQLGKRYNGSDPAS----GPSVQDKYVTALYFTFSS 473

Query: 430 LTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVR 489
           LT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V+
Sbjct: 474 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 533

Query: 490 DFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHP 549
           +F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R +    P
Sbjct: 534 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 593

Query: 550 AFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGK 609
           AF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVAILGK
Sbjct: 594 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 653

Query: 610 GDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCN 669
            D+FG+          + A+VRALTYCDLH I+R  LL+VLD Y AFA SF   L +T N
Sbjct: 654 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 713

Query: 670 LR 671
           LR
Sbjct: 714 LR 715


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  526 bits (1355), Expect = e-149
 Identities = 302/813 (37%), Positives = 483/813 (59%), Gaps = 58/813 (7%)

Query: 6   RGLVAPQNTFLENIVRR--SSESSFLLGNAQIVD-WPVVYSNDGFCKLSGYHRADVMQKS 62
           +GL+APQNTFL+ I  R   + S+F+L NAQ+   +P+VY +DGFC+L+G+ R +VMQKS
Sbjct: 5   KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            +C F++G  T+++ + ++ ++ +       E++ YKKN +P W  + I PI+NE   VV
Sbjct: 65  CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124

Query: 123 LFLCTFKDITLFKQPI-----EDDSTKGWTKFA-RLTRALTNSRSVLQQLTPMNKTEVVH 176
           LFL +FKDIT  K  I     ++D  KG ++       A   SR+VL  ++        H
Sbjct: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISG-------H 177

Query: 177 KHSRLAEVLQLGSDIL------PQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAI 230
              R    L++ +++       P+YK    K    I+LH+  FK  WDW+IL+ TFY A+
Sbjct: 178 LQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAV 237

Query: 231 MVPYNVSFKTKQN---NIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMN 287
            VPYNV F    +     +  V D  V+++F++DI+LNF TT+V   G+VI + + I ++
Sbjct: 238 TVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIH 297

Query: 288 YLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAA 347
           Y+ TWF+IDL++ LP+D++ AF NV   + SL   LK VRLLRL R+ +KLD Y ++   
Sbjct: 298 YVTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI 354

Query: 348 VLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAG 407
           VL LL+ +F L+AHW+ACIWY IG  E  D      ++  WL++L   + +PY  N + G
Sbjct: 355 VLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEV-GWLHELGKRLESPYYGNNTLG 413

Query: 408 IWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNV 467
               GPS  S Y+++LYFT++SLT++GFGN++  TD EK+FS+  M++G+L++A +FGNV
Sbjct: 414 ----GPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNV 469

Query: 468 TTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSI 527
           T I Q+MY+  + YH    +++DF++++ +P+ L +R+++Y  +TWS++ GID+ ++L  
Sbjct: 470 TAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKD 529

Query: 528 CPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDAL 587
            P ++R+DI +HLN+++  +   F  AS GCLR+L++  +T  CAPG+ +   G+++ A+
Sbjct: 530 FPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAI 588

Query: 588 CFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALL 647
            FV SGS+EV++D  V+AILGKGD+ G     +  +    A+V+ALTYCDL  I  + L 
Sbjct: 589 YFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLF 648

Query: 648 KVLDFYTAFANSFSRNL--TLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDH- 704
           +VLD Y  +A+ F  ++   LT NLR+          + +   RL  K+ V+ S P  + 
Sbjct: 649 EVLDLYPEYAHKFVEDIQHDLTYNLRE--------GHESDVISRLSNKSMVSQSEPKGNG 700

Query: 705 PVRKLFQKFKQQKELRNQGS-----------TQGDPERNQLQVESRSLQNGASITGTSVV 753
            + K      + +E   +G            T+G   RN+ +V S     G S+   +  
Sbjct: 701 NINKRLPSIVEDEEEEEEGEEEEAVSLSPICTRGSSSRNK-KVGSNKAYLGLSLKQLASG 759

Query: 754 TVSQITPIQTSLA-YVKTSESLKQNNRDAMELK 785
           TV   +PI+ S +   KT + +   N +  + K
Sbjct: 760 TVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKEK 792


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  502 bits (1292), Expect = e-142
 Identities = 281/699 (40%), Positives = 424/699 (60%), Gaps = 47/699 (6%)

Query: 6   RGLVAPQNTFLENIVRR--SSESSFLLGNAQIVD-WPVVYSNDGFCKLSGYHRADVMQKS 62
           RGL+APQNTFL+ I  R   + S+F+LGNAQ+   +PVVY +DGFC L+G+ RA+VMQ+ 
Sbjct: 5   RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
             CSF+YG  T +   +++R+  D ++    E++LY+K+  P W  + + PI+NE  +V 
Sbjct: 65  CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124

Query: 123 LFLCTFKDITLFKQPIEDDSTK----GWTKFARLTRALTN-----SRSVLQQLTPMNKTE 173
           LFL + KDI+  K     D  K    G  ++ R      N     SR+VL  L+   + +
Sbjct: 125 LFLVSHKDISETKNRGGPDRWKETGGGRRRYGRARSKGFNANRRRSRAVLYHLSGHLQKQ 184

Query: 174 VVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVP 233
              KH +L + +      LP+YK  A +  P I+LH  A + TWD  IL+ T Y A+ VP
Sbjct: 185 PKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVP 243

Query: 234 YNVSFKTKQNNIAW----LVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYL 289
           Y+V   T +   A      V D  V+V+F++DIVLNF TTFV   G+V+  PK I ++Y+
Sbjct: 244 YSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYV 303

Query: 290 KTWFVIDLLSCLPYDIINAFE-NVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAV 348
            TWF++D+++ LP+D+++AF+ NV  G       LK VRLLRL R+  +LD Y +Y A V
Sbjct: 304 TTWFLLDVIAALPFDLLHAFKVNVYFGA----HLLKTVRLLRLLRLLPRLDRYSQYSAVV 359

Query: 349 LVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRY------ 402
           L LL+ VF L+AHW+AC+W+ IG  E+    +   +I  WL +LA  + TPY        
Sbjct: 360 LTLLMAVFALLAHWVACVWFYIGQREIESSESELPEI-GWLQELARRLETPYYLVGRRPA 418

Query: 403 -NTSAGIWE----------------GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVE 445
              S+G  +                GGPS  S Y++SLYF ++SLT++GFGN++  TD E
Sbjct: 419 GGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTE 478

Query: 446 KMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERV 505
           K+FS+  M++G+L++A +FGNVT I Q+MYA    YH    ++RD+++++++PK L +R+
Sbjct: 479 KIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRM 538

Query: 506 MDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVE 565
           ++Y  +TW+++ GIDT ++L   P ++RADI +HL+++V  + P F  AS GCLRAL++ 
Sbjct: 539 LEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRALSLA 597

Query: 566 FQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAH 625
            +   C PG+ + H G+++ AL FV SGS+EV++   V+AILGKGD+ G    +   +  
Sbjct: 598 LRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVK 657

Query: 626 ACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL 664
           A A+V+ LTYC L  ++   L   L  Y  FA  FSR L
Sbjct: 658 ANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGL 696


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  491 bits (1265), Expect = e-138
 Identities = 274/704 (38%), Positives = 428/704 (60%), Gaps = 55/704 (7%)

Query: 6   RGLVAPQNTFLENIVRR--SSESSFLLGNAQIV-DWPVVYSNDGFCKLSGYHRADVMQKS 62
           +GL+APQNTFL+ I  R   + S+FLL NAQ    +P+VY +DGFC+L+GY R +VMQK+
Sbjct: 5   KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            +C F+YG  T +  ++++ +  + ++ +  E+  Y+K+ +  W  + + PI+NE  +VV
Sbjct: 65  CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124

Query: 123 LFLCTFKDITLFKQP-IEDDSTKGWTKFA----------RLTRALTNSRSVLQQLTPMNK 171
           LFL +FKDIT    P +     +G +             +   A   SR+VL +LT    
Sbjct: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTG--- 181

Query: 172 TEVVHKHSRLAEVLQLGSDI------LPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225
               H   R    ++  +++      +P+YK  +      ++LHY   K  WD +IL+ T
Sbjct: 182 ----HFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLAT 237

Query: 226 FYTAIMVPYNVSFK----TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDP 281
           FY A+ VPYNV F     T   +   LV D  V+++F++DI+LNF TT+V   G+VIS P
Sbjct: 238 FYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAP 297

Query: 282 KLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY 341
           + I ++YL TWF IDL++ LP+D++  F      ++SL   LK VRLLRL R+ +KL+ Y
Sbjct: 298 RSIGLHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQKLERY 354

Query: 342 LEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID-SWLYQLALSIGTPY 400
            +  A VL LL+ VF L+AHW+ACIWY IG  E+  E  + +  D  WL++L   +  PY
Sbjct: 355 SQCSAVVLTLLMSVFALLAHWMACIWYVIGRREM--EANDPLLWDIGWLHELGKRLEVPY 412

Query: 401 RYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLY 460
             N S G    GPS+ S Y+++LYFT++SLT++GFGN+   TD EK+FS+  M++G+L++
Sbjct: 413 -VNGSVG----GPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMH 467

Query: 461 ATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGID 520
           A +FGNVT I Q+MY+  + YH  + +++DF++++++P+ L +R+++Y  +TW+++ GID
Sbjct: 468 AVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGID 527

Query: 521 TEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHA 580
             ++L   P ++RADI +HLNR++  + P F  AS GCLRAL++  +T  CAPG+ +   
Sbjct: 528 ANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRR 586

Query: 581 GESVDALCFVVSGSLEVIQDDEVVAILGKGDVFG----------DIFWKETTLAHACANV 630
           G+++ A  +V SGSLEV++D+ V+AILGKGD+ G           +      +    A+V
Sbjct: 587 GDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADV 646

Query: 631 RALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--TLTCNLRK 672
           +ALTYC L  +    L +VL  Y  +  +F   L   LT NLR+
Sbjct: 647 KALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQ 690


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  470 bits (1209), Expect = e-132
 Identities = 239/517 (46%), Positives = 343/517 (66%), Gaps = 20/517 (3%)

Query: 166 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 359 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 418

Query: 226 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 274
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 419 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 478

Query: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 479 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 537

Query: 335 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 394
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 538 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 593

Query: 395 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 454
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 594 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 649

Query: 455 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 650 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 709

Query: 515 MSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPG 574
            + GID   VL   P+ ++ADIC+HLN+ +     AFR AS GCLRALA++F+T H  PG
Sbjct: 710 YTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPG 769

Query: 575 DLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALT 634
           D + H G+ + AL F+  GS+E+++DD VVAILGK D+FG++         + A+VRALT
Sbjct: 770 DTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALT 829

Query: 635 YCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 671
           YCDLH I+RE LL+VLD Y  F++ F  NL LT NLR
Sbjct: 830 YCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLR 866



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 2/130 (1%)

Query: 5   KRGLVAPQNTFLENIVRR--SSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
           +RG VAPQNTFL  I+R+       F++ NA++ +  ++Y NDGFC+++G+ R DVMQK 
Sbjct: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+    +
Sbjct: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123

Query: 123 LFLCTFKDIT 132
           +F+  F+ +T
Sbjct: 124 MFIINFEYVT 133


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  463 bits (1191), Expect = e-130
 Identities = 237/528 (44%), Positives = 339/528 (64%), Gaps = 25/528 (4%)

Query: 156 LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 215
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408

Query: 216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 263
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468

Query: 264 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 323
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524

Query: 324 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 383
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583

Query: 384 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635

Query: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695

Query: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755

Query: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTL 623
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILGK D+FG+        
Sbjct: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARP 815

Query: 624 AHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLR 671
             +  +VRALTYCDLH I R+ LL+VLD Y  F++ F  +L +T NLR
Sbjct: 816 GKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 863



 Score =  103 bits (258), Expect = 6e-22
 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
           +RG VAPQNTFL+ I+R+    S  F++ NA++ +  V+Y NDGFC+L GY RA+VMQ+ 
Sbjct: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE   V+
Sbjct: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123

Query: 123 LFLCTFKDI---TLFKQPIEDDSTKG 145
           +F+  F+ +    +   P  D + +G
Sbjct: 124 MFILNFEVVMEKDMVGSPAHDTNHRG 149


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  461 bits (1187), Expect = e-129
 Identities = 234/501 (46%), Positives = 329/501 (65%), Gaps = 25/501 (4%)

Query: 183 EVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQ 242
           EVL LG+D+LP+YK +AP+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F  K+
Sbjct: 36  EVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKE 95

Query: 243 NNIA------------WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLK 290
                             V+D +VD++F+VDI++NF TT+V    EV+S P  I ++Y K
Sbjct: 96  TEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFK 155

Query: 291 TWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLV 350
            WF+ID+++ +P+D++        G   L   LK  RLLRL RVARKLD Y EYGAAVL 
Sbjct: 156 GWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLF 211

Query: 351 LLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWE 410
           LL+C F L+AHWLACIWY+IG+ E    + + I    WL+ L   IG PY    S+G+  
Sbjct: 212 LLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI---GWLHNLGDQIGKPYN---SSGL-- 262

Query: 411 GGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTI 470
           GGPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I
Sbjct: 263 GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAI 322

Query: 471 FQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPK 530
            Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ +Y    WS + GID   VL   P+
Sbjct: 323 IQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 382

Query: 531 DMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFV 590
            ++ADIC+HLNR +      FR A+ GCLRALA++F+T H  PGD + HAG+ + AL F+
Sbjct: 383 CLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFI 442

Query: 591 VSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVL 650
             GS+E+++ D VVAILGK D+FG+          +  +VRALTYCDLH I R+ LL+VL
Sbjct: 443 SRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVL 502

Query: 651 DFYTAFANSFSRNLTLTCNLR 671
           D Y  F++ F  +L +T NLR
Sbjct: 503 DMYPEFSDHFWSSLEITFNLR 523


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  456 bits (1174), Expect = e-128
 Identities = 259/722 (35%), Positives = 385/722 (53%), Gaps = 118/722 (16%)

Query: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
           +RG VAPQNT+L+ I+R+    S  FL+ NAQ+ +  ++Y NDGFC+L GY R +VMQ+ 
Sbjct: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            TC F+ G  T    + ++ Q     E    ++L Y+K+ +     + + P++NE   V+
Sbjct: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123

Query: 123 LFLCTFKDITLFKQPIEDDS---------------------------------------- 142
           +F+  F+D+          S                                        
Sbjct: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183

Query: 143 -TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYKQEAP 200
            T  + +F  L +  ++S + ++ + P    E     + ++ +VL LG+D+LP+YK +AP
Sbjct: 184 FTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAP 242

Query: 201 KTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA-----------WLV 249
           +     ILHY  FK  WDW+IL+L  YTA+  PY+ +F     + +             V
Sbjct: 243 RIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTV 302

Query: 250 LDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAF 309
           +D +VD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  F
Sbjct: 303 VDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-IF 361

Query: 310 ENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYS 369
               +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACI   
Sbjct: 362 RTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACICSL 421

Query: 370 IGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTS 429
                                             TS G     P+ +S  V S+      
Sbjct: 422 ----------------------------------TSVGFGNVSPNTNSEKVFSI------ 441

Query: 430 LTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVR 489
                                 +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V+
Sbjct: 442 ---------------------CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 480

Query: 490 DFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHP 549
           +F++ +Q+P  L +R+ +Y    WS + GID   VL   P+ ++ADIC+HL+R +    P
Sbjct: 481 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 540

Query: 550 AFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGK 609
           AF  A  GCLRALAV+F+T H  PGD + H G+ +  L F+  GS+E+++DD VVAILGK
Sbjct: 541 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 600

Query: 610 GDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCN 669
            D+FG+          + A+VRALTYCDLH I+R  LL+VLD Y AFA SF   L +T N
Sbjct: 601 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 660

Query: 670 LR 671
           LR
Sbjct: 661 LR 662


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  414 bits (1063), Expect = e-115
 Identities = 209/467 (44%), Positives = 301/467 (64%), Gaps = 25/467 (5%)

Query: 156 LTNSRSVLQQLTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKT 215
           L +  S  + + P  K    +   ++ +VL LG+D+LP+YK +AP+     ILHY  FK 
Sbjct: 349 LASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKA 408

Query: 216 TWDWVILILTFYTAIMVPYNVSFKTKQNNIA------------WLVLDSVVDVIFLVDIV 263
            WDW+IL+L  YTA+  PY+ +F  K+                  V+D +VD++F+VDI+
Sbjct: 409 VWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDIL 468

Query: 264 LNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSL 323
           +NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   L
Sbjct: 469 INFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLL 524

Query: 324 KVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTI 383
           K  RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+IG+ E    + + I
Sbjct: 525 KTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQ-PHMDSRI 583

Query: 384 QIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443
               WL+ L   IG PY    S+G+  GGPS    YV++LYFT +SLT++GFGN++P T+
Sbjct: 584 ---GWLHNLGDQIGKPYN---SSGL--GGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTN 635

Query: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503
            EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +
Sbjct: 636 SEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQ 695

Query: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563
           R+ +Y    WS + GID   VL   P+ ++ADIC+HLNR +      FR A+ GCLRALA
Sbjct: 696 RLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALA 755

Query: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGKG 610
           ++F+T H  PGD + HAG+ + AL F+  GS+E+++ D VVAILG G
Sbjct: 756 MKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMG 802



 Score =  103 bits (258), Expect = 6e-22
 Identities = 50/146 (34%), Positives = 85/146 (58%), Gaps = 5/146 (3%)

Query: 5   KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
           +RG VAPQNTFL+ I+R+    S  F++ NA++ +  V+Y NDGFC+L GY RA+VMQ+ 
Sbjct: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            TC F++G  T ++   ++ Q     E    E+  Y+K+ +     + + P++NE   V+
Sbjct: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123

Query: 123 LFLCTFKDI---TLFKQPIEDDSTKG 145
           +F+  F+ +    +   P  D + +G
Sbjct: 124 MFILNFEVVMEKDMVGSPAHDTNHRG 149


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  327 bits (838), Expect = 3e-89
 Identities = 167/385 (43%), Positives = 248/385 (64%), Gaps = 21/385 (5%)

Query: 166 LTPMNKTEVVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225
           + P  K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L 
Sbjct: 352 IAPKVKDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLV 411

Query: 226 FYTAIMVPYNVSF------KTKQNNIAWL-----VLDSVVDVIFLVDIVLNFHTTFVGPG 274
            YTAI  PY+ +F      + K+    +      V+D +VD++F++DI++NF TT+V   
Sbjct: 412 IYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQN 471

Query: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
            EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL RV
Sbjct: 472 EEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVRV 530

Query: 335 ARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLAL 394
           ARKLD Y EYGAAVL+LL+C+F L+AHWLACIWY+IG+ E    +T+ I    WL  L  
Sbjct: 531 ARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVER-PYLTDKI---GWLDSLGQ 586

Query: 395 SIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMM 454
            IG   RYN S      GPS    YV++LYFT +SLT++GFGN++P T+ EK+FS+ +M+
Sbjct: 587 QIGK--RYNDSDS--SSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVML 642

Query: 455 VGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWS 514
           +GSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    W+
Sbjct: 643 IGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWT 702

Query: 515 MSKGIDTEKV-LSICPKDMRADICV 538
            + GID   V +S+   +  A I V
Sbjct: 703 YTNGIDMNMVCMSVFQNESAAGIIV 727



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 47/130 (36%), Positives = 75/130 (57%), Gaps = 2/130 (1%)

Query: 5   KRGLVAPQNTFLENIVRR--SSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
           +RG VAPQNTFL  I+R+       F++ NA++ +  ++Y NDGFC+++G+ R DVMQK 
Sbjct: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63

Query: 63  STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
            TC F++G  T +  I ++ Q     E    EV  Y KN +       I P++N+    +
Sbjct: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123

Query: 123 LFLCTFKDIT 132
           +F+  F+ +T
Sbjct: 124 MFIINFEYVT 133


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  176 bits (446), Expect = 1e-43
 Identities = 136/501 (27%), Positives = 228/501 (45%), Gaps = 60/501 (11%)

Query: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246
           GS    + +QE  KT    I+H Y  F+  WD ++LI+     +++P  ++F T+Q    
Sbjct: 115 GSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTP 174

Query: 247 WLVLDSVVDVIFLVDIVLNFHTTFVG-PGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305
           W++ +   D +FL+D+++NF T  V     E+I DPK+I+MNYLK+WFV+D +S +P D 
Sbjct: 175 WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDY 234

Query: 306 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 347
           I  F  V++G+ S                 L ++RLLRL R+ R +  + E     Y  A
Sbjct: 235 I--FLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 292

Query: 348 VLVL----LVCVFGLVAHWLACIWYSI---GDYEVIDEVT-NTIQIDSWLYQLALSIGTP 399
             V+    L+ +  L+ HW  C+ + +    D+     V+ N +  DSW        G  
Sbjct: 293 SAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW--------GKQ 344

Query: 400 YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLL 459
           Y Y                   +L+  M+ +  IG+G  AP +  +   ++  M+VG+  
Sbjct: 345 YSY-------------------ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATC 385

Query: 460 YATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGI 519
           YA   G+ T + Q + ++  +Y E    V  ++  +++P  + +++ DY    +   K  
Sbjct: 386 YAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKIF 444

Query: 520 DTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYH 579
           D E +L+     +R +I     RK+    P F  A    + A+  + +     PGD I  
Sbjct: 445 DEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIR 504

Query: 580 AGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLH 639
            G     + F+  G   VI        L  G  FG+I     T     A+VRA TYC L+
Sbjct: 505 EGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICL--LTKGRRTASVRADTYCRLY 562

Query: 640 IIKREALLKVLDFYTAFANSF 660
            +  +   +VL+ Y     +F
Sbjct: 563 SLSVDNFNEVLEEYPMMRRAF 583


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  170 bits (430), Expect = 7e-42
 Identities = 130/495 (26%), Positives = 218/495 (44%), Gaps = 48/495 (9%)

Query: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246
           GS    + +QE  K+    I+H Y  F+  WD  +L+L     I++P  ++F   +N   
Sbjct: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294

Query: 247 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305
           W+V + V D  FL+D+VLNF T   V    E+I DP+ I+M YLK+WF++D +S +P D 
Sbjct: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354

Query: 306 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLEYG------AAV 348
           I       +D  +     +L++V         RLLRL R+ R +  + E        A+ 
Sbjct: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414

Query: 349 LVLLVCVFG---LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS 405
           +V +V + G   L+ HW  C+ + +        +      D W       +      N S
Sbjct: 415 VVRIVNLIGMMLLLCHWDGCLQFLV-------PMLQDFPDDCW-------VSINNMVNNS 460

Query: 406 AGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFG 465
            G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA   G
Sbjct: 461 WG---------KQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIG 511

Query: 466 NVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVL 525
           + T + Q + ++  +Y E    V  ++  +++P    +R+ DY    +   K  D E +L
Sbjct: 512 HATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFDEESIL 570

Query: 526 SICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVD 585
               + +R +I     RK+    P F  A    + ++  + +     PGD I   G    
Sbjct: 571 GELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGK 630

Query: 586 ALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREA 645
            + F+  G + V+        L  G  FG+I     T     A+VRA TYC L+ +  + 
Sbjct: 631 KMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRGRRTASVRADTYCRLYSLSVDN 688

Query: 646 LLKVLDFYTAFANSF 660
             +VL+ Y     +F
Sbjct: 689 FNEVLEEYPMMRRAF 703


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  168 bits (425), Expect = 3e-41
 Identities = 130/497 (26%), Positives = 220/497 (44%), Gaps = 52/497 (10%)

Query: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246
           GS    + +QE  K+    I+H Y  F+  WD+ +L+      I++P  ++F   +    
Sbjct: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243

Query: 247 WLVLDSVVDVIFLVDIVLNFHTTFV-GPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 305
           W+V + V D  FL+D+VLNF T  V     E+I DP+ I+  YL+TWFV+D +S +P D 
Sbjct: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303

Query: 306 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYLE-----YGAA 347
           I  F  V++GI S                 L ++RLLRL R+ R +  + E     Y  A
Sbjct: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361

Query: 348 VLVLLVC----VFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 403
             V+ +C    +  L+ HW  C+ + +        +      + W     +SI     ++
Sbjct: 362 SAVMRICNLISMMLLLCHWDGCLQFLV-------PMLQDFPRNCW-----VSINGMVNHS 409

Query: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463
            S            LY  +L+  M+ +  IG+G  AP +  +   ++  M+VG+  YA  
Sbjct: 410 WS-----------ELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMF 458

Query: 464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 523
            G+ T + Q + ++  +Y E    V  ++  +++P    +++ DY    +   K  D + 
Sbjct: 459 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDEDS 517

Query: 524 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 583
           +L      +R +I     RK+    P F  A    + A+  + +     PGD I   G  
Sbjct: 518 ILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTI 577

Query: 584 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 643
              + F+  G + V+        L  G  FG+I     T     A+VRA TYC L+ +  
Sbjct: 578 GKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 635

Query: 644 EALLKVLDFYTAFANSF 660
           +   +VL+ Y     +F
Sbjct: 636 DNFNEVLEEYPMMRRAF 652


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  164 bits (415), Expect = 4e-40
 Identities = 132/521 (25%), Positives = 231/521 (44%), Gaps = 53/521 (10%)

Query: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246
           GS    + +QE  K+    I+H Y  F+  WD ++L+L     I++P  ++F  ++N+  
Sbjct: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125

Query: 247 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYD- 304
           W+V + + D  FL+D+VLNF T   V  G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185

Query: 305 ---IINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLE-----YGAA 347
              ++     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245

Query: 348 VLVL----LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 403
             V+    L+ +  L+ HW  C+ + +        +      D W       +   +  N
Sbjct: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLV-------PMLQDFPPDCW-------VSINHMVN 291

Query: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463
            S G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA  
Sbjct: 292 HSWG---------RQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342

Query: 464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 523
            G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   K  D E 
Sbjct: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEES 401

Query: 524 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 583
           +L    + +R +I     R +    P F  A    + A+  + +     PGDL+   G  
Sbjct: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461

Query: 584 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 643
              + F+  G L V+        L  G  FG+I     T     A+VRA TYC L+ +  
Sbjct: 462 GRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 519

Query: 644 EALLKVLDFYTAFANSF---SRNLTLTCNLRKRIIFRKISD 681
           +    VL+ +     +F   + +  L    +  I+ RK S+
Sbjct: 520 DHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSE 560


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  152 bits (384), Expect = 1e-36
 Identities = 145/583 (24%), Positives = 256/583 (43%), Gaps = 87/583 (14%)

Query: 209 HYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNF 266
           +YC     W +VI +   Y   ++     F   Q    + WLVLD V DV+++ D+ +  
Sbjct: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194

Query: 267 HTTFVGPGGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKV 325
            T F+  G  ++ D K +R NY+ T  F +D+ S +P D+I    ++          L  
Sbjct: 195 RTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253

Query: 326 VRLLRL-GRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQ 384
            R+     R   + ++   +  + LVL + V   + HW ACI+Y+I         +    
Sbjct: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILV---IIHWNACIYYAISK-------SIGFG 303

Query: 385 IDSWLYQLALSIGTP-YRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTD 443
           +D+W+Y    +I  P Y Y                Y+  LY++  +LTTIG     P  D
Sbjct: 304 VDTWVYP---NITDPEYGYLARE------------YIYCLYWSTLTLTTIG-ETPPPVKD 347

Query: 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSE 503
            E +F +   ++G L++ATI GNV ++   M A    +   ++ V+ +++  +V KG+  
Sbjct: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407

Query: 504 RVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALA 563
           +V+ +    W+  K +D  ++L   P  +RA+I ++++     +   F     G L  L 
Sbjct: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467

Query: 564 VEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIF---W 618
           ++ +    +PGD I   G+    +  +  G L V+ DD V   A+L  G  FG+I     
Sbjct: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527

Query: 619 KETTLAH-ACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFR 677
           K + + +   AN+R+L Y DL  + ++ L++ +  Y                  K+++  
Sbjct: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD---------------AKKVLEE 572

Query: 678 KISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSTQGDPERNQLQVE 737
           +  ++    +E L  +NEV  S+ VD            Q++L       G  E N   + 
Sbjct: 573 RGREILM--KEGLLDENEVATSMEVD-----------VQEKL-------GQLETNMETLY 612

Query: 738 SRSLQNGASITGTSVVTVSQITPIQTSLAYVKTSESLKQNNRD 780
           +R  +  A  TG       +IT ++T          +KQNN D
Sbjct: 613 TRFGRLLAEYTGAQQKLKQRITVLET---------KMKQNNED 646


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  150 bits (379), Expect = 6e-36
 Identities = 128/513 (24%), Positives = 228/513 (44%), Gaps = 58/513 (11%)

Query: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191

Query: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 192 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 246

Query: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 247 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 300

Query: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 301 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 339

Query: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 340 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 398

Query: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 399 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 458

Query: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 604
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 459 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 518

Query: 605 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y     
Sbjct: 519 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 578

Query: 659 SF---SRNLTLTCNLRKRIIFRKISDVKKEEEE 688
           +     R + +  NL    + R  +D K  EE+
Sbjct: 579 ALEEKGRQILMKDNLIDEELARAGADPKDLEEK 611


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  150 bits (379), Expect = 6e-36
 Identities = 128/513 (24%), Positives = 228/513 (44%), Gaps = 58/513 (11%)

Query: 196 KQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSV 253
           K++A    P   L+Y      W   I +  FY   ++     F   Q+   + WLVLD  
Sbjct: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209

Query: 254 VDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVD 313
            DV++++D+++   T F+  G  V    +L +     T F +D+LS +P D+        
Sbjct: 210 ADVLYVLDVLVRARTGFLEQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL----- 264

Query: 314 EGISSLFSSLKVVRLLRLGRVARKLD---------HYLEYGAAVLVLLVCVFGLVAHWLA 364
             + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW A
Sbjct: 265 -KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWNA 318

Query: 365 CIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLY 424
           CI+++I  +            DSW+Y    +I  P     S             Y+ SLY
Sbjct: 319 CIYFAISKFIGFGT-------DSWVYP---NISIPEHGRLSRK-----------YIYSLY 357

Query: 425 FTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEM 484
           ++  +LTTIG     P  D E +F V   +VG L++ATI GNV ++   M A+   +   
Sbjct: 358 WSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAK 416

Query: 485 LNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKV 544
           +++++ +++  +V K L  RV+ +    W+  K +D ++VL   P  ++A+I ++++   
Sbjct: 417 IDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDT 476

Query: 545 FNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV 604
             +   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD V 
Sbjct: 477 LKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVT 536

Query: 605 --AILGKGDVFGDI----FWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658
              +L  G  FG+I         +     AN+R++ Y DL  + ++ L++ L  Y     
Sbjct: 537 QFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKK 596

Query: 659 SF---SRNLTLTCNLRKRIIFRKISDVKKEEEE 688
           +     R + +  NL    + R  +D K  EE+
Sbjct: 597 ALEEKGRQILMKDNLIDEELARAGADPKDLEEK 629


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  144 bits (363), Expect = 4e-34
 Identities = 126/497 (25%), Positives = 218/497 (43%), Gaps = 43/497 (8%)

Query: 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296

Query: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350

Query: 335 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 390
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 403

Query: 391 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 450
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 404 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 448

Query: 451 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 510
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 449 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 508

Query: 511 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 570
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 509 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 568

Query: 571 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIFWKETTLAHA-- 626
            +PGD I   G+    +  +  G L V+ DD V    +L  G  FG+I       + A  
Sbjct: 569 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGN 628

Query: 627 --CANVRALTYCDLHIIKREALLKVLDFY---TAFANSFSRNLTLTCNLRKRIIFRKISD 681
              AN++++ Y DL  + ++ L++ L  Y           + + +   L    I    SD
Sbjct: 629 RRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSD 688

Query: 682 VKKEEEERLRQKNEVTL 698
            K  EE+  R +  V L
Sbjct: 689 PKDLEEKVTRMEGSVDL 705


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  144 bits (363), Expect = 4e-34
 Identities = 126/497 (25%), Positives = 218/497 (43%), Gaps = 43/497 (8%)

Query: 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIA--WLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
           W + I +   Y   MV     F   Q++    WL+LD V D+++L+D+ +   T ++  G
Sbjct: 168 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 227

Query: 275 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 228 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 281

Query: 335 A---RKLDHYLEYGAAVLVL-LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLY 390
               ++ +    Y     +  LV    ++ HW AC++YSI               D+W+Y
Sbjct: 282 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGN-------DTWVY 334

Query: 391 QLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSV 450
                I  P          E G      YV SLY++  +LTTIG     P  D E +F V
Sbjct: 335 P---DINDP----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVV 379

Query: 451 AMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIV 510
              ++G L++ATI GN+ ++   M A    +   ++ ++ ++    V K + +RV+ +  
Sbjct: 380 VDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFD 439

Query: 511 STWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIH 570
             W+  K +D ++VL   P  +RA+I ++++     +   F     G L  L ++ Q   
Sbjct: 440 YLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQV 499

Query: 571 CAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDIFWKETTLAHA-- 626
            +PGD I   G+    +  +  G L V+ DD V    +L  G  FG+I       + A  
Sbjct: 500 YSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGN 559

Query: 627 --CANVRALTYCDLHIIKREALLKVLDFY---TAFANSFSRNLTLTCNLRKRIIFRKISD 681
              AN++++ Y DL  + ++ L++ L  Y           + + +   L    I    SD
Sbjct: 560 RRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGSD 619

Query: 682 VKKEEEERLRQKNEVTL 698
            K  EE+  R +  V L
Sbjct: 620 PKDLEEKVTRMEGSVDL 636


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  132 bits (333), Expect = 1e-30
 Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 44/451 (9%)

Query: 217 WDWVILILTFYTAIMVPYNVSFKTKQNN--IAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
           W   ++    Y  I++     F   Q+   +AWLVLD   D+++L+D+V+ FHT F+  G
Sbjct: 37  WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFLEQG 96

Query: 275 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 333
             V+ D   I   Y++TW F +DL S +P D++         +     +L++ R LR  R
Sbjct: 97  ILVV-DKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149

Query: 334 VARKLDHYLEYGA-----AVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSW 388
           +    D      A      +  L++ +F +V HW +C+++++  Y            D+W
Sbjct: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGR-------DAW 201

Query: 389 LYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMF 448
           +Y                    G       Y+ S YF+   LTT+G     P  + E +F
Sbjct: 202 VYPDPAQ--------------PGFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYLF 246

Query: 449 SVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDY 508
            V   ++  + +ATI G+++++   M      ++     V+ ++KL  V + L  RV+D+
Sbjct: 247 MVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVIDW 306

Query: 509 IVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQT 568
                   K  +   +L   P+ +RA++ V ++    +    F+      L  L ++ Q 
Sbjct: 307 YQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQP 366

Query: 569 IHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVV--AILGKGDVFGDI----FWKETT 622
              +PG+ +   G+    +  +  G L V+ DD +   A+LG G  FG+I         +
Sbjct: 367 QTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNMS 426

Query: 623 LAHACANVRALTYCDLHIIKREALLKVLDFY 653
                AN+++L Y DL  + +E L +VL  Y
Sbjct: 427 GNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  108 bits (271), Expect = 2e-23
 Identities = 102/448 (22%), Positives = 190/448 (42%), Gaps = 56/448 (12%)

Query: 217  WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDI-VLNFHTTFVGPGG 275
            W+W   +      I V +   ++T  N   WL++D + D+I+ +DI V      FV  GG
Sbjct: 667  WNWNCWL------IPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR-GG 719

Query: 276  EVISDPKLIRMNYLKTW-FVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRV 334
            ++I+D K +R NYLK+  F +DLLS LP D    F  +  G++ L    + ++ +     
Sbjct: 720  DIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFFEF 775

Query: 335  ARKLDHYLEYGAAVLVLLVCVFGLVA-HWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLA 393
              +L+  L       V+    + L + H  +C++Y    Y+ +           W+Y   
Sbjct: 776  NSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQGLGST-------HWVYD-- 826

Query: 394  LSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMM 453
              +G  Y                   +   YF + +L TIG G   P T  E +F +   
Sbjct: 827  -GVGNSY-------------------IRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNY 865

Query: 454  MVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTW 513
              G   ++ + G +  +     A    Y   +++   ++  Y++PK +  RV  +   TW
Sbjct: 866  FTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTW 925

Query: 514  SMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAP 573
                 +D  +++   P  MR D+ + +N  + ++   F+      +  +    +++   P
Sbjct: 926  HSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLP 985

Query: 574  GDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA-----H 625
             D +   GE    +  + +G ++V+       V+  L  G VFG+I    + LA      
Sbjct: 986  NDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEI----SLLAVGGGNR 1041

Query: 626  ACANVRALTYCDLHIIKREALLKVLDFY 653
              ANV A  + +L I+ ++ L ++L  Y
Sbjct: 1042 RTANVVAHGFTNLFILDKKDLNEILVHY 1069


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  107 bits (268), Expect = 4e-23
 Identities = 94/449 (20%), Positives = 191/449 (42%), Gaps = 52/449 (11%)

Query: 219 WVILILTFYT--AIMVPYNVSF--KTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPG 274
           W++L+   Y      +P  + F  +T  N   WL+ D + D+I+L D++          G
Sbjct: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280

Query: 275 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGR 333
           G++I D   +R +Y   T F +D+ S +P+DI   F     G + +F + ++++      
Sbjct: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFF----GFNPMFRANRMLKYTSFFE 336

Query: 334 VARKLDHYLEYGAAVLVLLVCVFGL-VAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQL 392
               L+  ++      V+    + L + H  AC++Y   +YE I           W+Y  
Sbjct: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTR-------WVYD- 388

Query: 393 ALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAM 452
                                 + + Y+   Y+ + +L TIG G   P T  E +F +  
Sbjct: 389 ---------------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLN 426

Query: 453 MMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVST 512
              G  +++++ G +  +     AN N +   +++   ++  Y +PK + +RV  +   T
Sbjct: 427 FFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYT 486

Query: 513 WSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCA 572
           W   + +D   +L   P  ++  + + +N  + ++   F+      +  + +  +++   
Sbjct: 487 WDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYL 546

Query: 573 PGDLIYHAGESVDALCFVVSGSLEVI---QDDEVVAILGKGDVFGDIFWKETTLA----- 624
           PGD +   GE    +  +  G ++V+      +V+  L  G VFG+I    + LA     
Sbjct: 547 PGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEI----SLLAAGGGN 602

Query: 625 HACANVRALTYCDLHIIKREALLKVLDFY 653
              ANV A  + +L  + ++ L ++L  Y
Sbjct: 603 RRTANVVAHGFANLLTLDKKTLQEILVHY 631


>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
           [Homo sapiens]
          Length = 271

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 8/70 (11%)

Query: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463
           TS G WE         V S +F+++++TTIG+GN++P T   ++F +   +VG  L   +
Sbjct: 96  TSMGRWE--------LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVV 147

Query: 464 FGNVTTIFQQ 473
              +  + QQ
Sbjct: 148 LNRLGHLMQQ 157


>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
           [Homo sapiens]
          Length = 332

 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 22/70 (31%), Positives = 38/70 (54%), Gaps = 8/70 (11%)

Query: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463
           TS G WE         V S +F+++++TTIG+GN++P T   ++F +   +VG  L   +
Sbjct: 96  TSMGRWE--------LVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNLVV 147

Query: 464 FGNVTTIFQQ 473
              +  + QQ
Sbjct: 148 LNRLGHLMQQ 157


>gi|14589851 potassium channel, subfamily K, member 2 isoform b
           [Homo sapiens]
          Length = 411

 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 12/91 (13%)

Query: 381 NTIQIDSWLYQL--ALSIGTPYRYNTSAGI--WEGGPSKDSLYVSSLYFTMTSLTTIGFG 436
           N+ ++D  + Q+  A++ G     NTS  I  W+ G        SS +F  T +TTIGFG
Sbjct: 95  NSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLG--------SSFFFAGTVITTIGFG 146

Query: 437 NIAPTTDVEKMFSVAMMMVGSLLYATIFGNV 467
           NI+P T+  K+F +   ++G  L+  +   V
Sbjct: 147 NISPRTEGGKIFCIIYALLGIPLFGFLLAGV 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,025,406
Number of Sequences: 37866
Number of extensions: 1555872
Number of successful extensions: 5242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 4985
Number of HSP's gapped (non-prelim): 184
length of query: 988
length of database: 18,247,518
effective HSP length: 112
effective length of query: 876
effective length of database: 14,006,526
effective search space: 12269716776
effective search space used: 12269716776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.