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Search of human proteins with 218505779
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo
sapiens]
(1886 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 3778 0.0
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 3623 0.0
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 3617 0.0
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 3611 0.0
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 3600 0.0
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 3566 0.0
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 3555 0.0
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 3509 0.0
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 2607 0.0
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 2607 0.0
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 2600 0.0
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 2593 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 306 9e-83
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 285 3e-76
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 279 2e-74
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 271 3e-72
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 268 5e-71
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 264 7e-70
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 254 4e-67
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 251 6e-66
gi|16933557 dachsous 1 precursor [Homo sapiens] 248 4e-65
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 228 4e-59
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 202 2e-51
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 202 2e-51
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 195 3e-49
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 195 3e-49
gi|157426847 protocadherin 19 isoform a [Homo sapiens] 194 5e-49
gi|157426845 protocadherin 19 isoform b [Homo sapiens] 194 5e-49
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 190 1e-47
gi|14270499 protocadherin gamma subfamily B, 4 isoform 2 precurs... 189 2e-47
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 3778 bits (9796), Expect = 0.0
Identities = 1886/1886 (100%), Positives = 1886/1886 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Query: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE
Sbjct: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
Query: 661 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 720
ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA
Sbjct: 661 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 720
Query: 721 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 780
TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN
Sbjct: 721 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 780
Query: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 840
VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT
Sbjct: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 840
Query: 841 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 900
VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ
Sbjct: 841 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 900
Query: 901 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960
FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE
Sbjct: 901 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960
Query: 961 IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYV 1020
IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYV
Sbjct: 961 IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYV 1020
Query: 1021 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1080
NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG
Sbjct: 1021 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1080
Query: 1081 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFH 1140
GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFH
Sbjct: 1081 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFH 1140
Query: 1141 NMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEIL 1200
NMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEIL
Sbjct: 1141 NMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEIL 1200
Query: 1201 DRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLD 1260
DRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLD
Sbjct: 1201 DRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLD 1260
Query: 1261 GKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPA 1320
GKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPA
Sbjct: 1261 GKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPA 1320
Query: 1321 ILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEEL 1380
ILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEEL
Sbjct: 1321 ILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEEL 1380
Query: 1381 GDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKS 1440
GDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKS
Sbjct: 1381 GDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDGSLKSNKLKS 1440
Query: 1441 ARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREK 1500
ARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREK
Sbjct: 1441 ARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKSKSLRGPREK 1500
Query: 1501 IQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTE 1560
IQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTE
Sbjct: 1501 IQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRGSSNPLLTTE 1560
Query: 1561 EANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNV 1620
EANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNV
Sbjct: 1561 EANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRTVELKSEPNV 1620
Query: 1621 ISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPP 1680
ISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPP
Sbjct: 1621 ISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNISPSACPLPP 1680
Query: 1681 PPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPP 1740
PPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPP
Sbjct: 1681 PPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPP 1740
Query: 1741 LLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTT 1800
LLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTT
Sbjct: 1741 LLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKSSMTQLSTTT 1800
Query: 1801 VCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEIT 1860
VCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEIT
Sbjct: 1801 VCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCPSEVTNMEIT 1860
Query: 1861 SEQNKGSLNNIVEGTEKQSHSQSTSL 1886
SEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1861 SEQNKGSLNNIVEGTEKQSHSQSTSL 1886
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 3623 bits (9395), Expect = 0.0
Identities = 1834/1957 (93%), Positives = 1848/1957 (94%), Gaps = 71/1957 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1370 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1429
PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1441 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1500
Query: 1430 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1489
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1501 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1560
Query: 1490 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1549
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1561 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1620
Query: 1550 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1609
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1621 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1680
Query: 1610 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1669
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1681 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1740
Query: 1670 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1729
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1741 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1800
Query: 1730 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1789
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1801 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1860
Query: 1790 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1849
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1861 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1920
Query: 1850 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1957
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 3617 bits (9379), Expect = 0.0
Identities = 1834/1962 (93%), Positives = 1848/1962 (94%), Gaps = 76/1962 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 416 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 476 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 536 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERS 595
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 596 TGILTLGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN- 633
I T+ + + +S R+ +L + A+D D + A N
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 634 -----------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA- 663
I++ +D P N+ V + NA
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 664 -------------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 704
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 705 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 764
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 765 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 825 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 885 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 944
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 945 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1004
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1005 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1064
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1065 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1124
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1125 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1184
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1185 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1244
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1245 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1304
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1305 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1364
ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1365 PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH 1424
PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAH 1500
Query: 1425 KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS 1484
KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS
Sbjct: 1501 KSAHVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFS 1560
Query: 1485 PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG 1544
PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG
Sbjct: 1561 PKIQAKSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTG 1620
Query: 1545 ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST 1604
ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST
Sbjct: 1621 ICTNKRGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFST 1680
Query: 1605 LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN 1664
LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN
Sbjct: 1681 LPTVSRTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFEN 1740
Query: 1665 FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP 1724
FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP
Sbjct: 1741 FAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPP 1800
Query: 1725 TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM 1784
TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM
Sbjct: 1801 TFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLM 1860
Query: 1785 PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS 1844
PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS
Sbjct: 1861 PAEKIKSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVS 1920
Query: 1845 ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1921 ELQTMCPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1962
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 3611 bits (9364), Expect = 0.0
Identities = 1831/1957 (93%), Positives = 1846/1957 (94%), Gaps = 73/1957 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1370 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1429
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1441 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1498
Query: 1430 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1489
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1499 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1558
Query: 1490 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1549
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1559 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1618
Query: 1550 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1609
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1619 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1678
Query: 1610 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1669
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1679 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1738
Query: 1670 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1729
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1739 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1798
Query: 1730 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1789
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1799 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1858
Query: 1790 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1849
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1859 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1918
Query: 1850 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1919 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1955
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 3600 bits (9335), Expect = 0.0
Identities = 1828/1957 (93%), Positives = 1843/1957 (94%), Gaps = 76/1957 (3%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1437
Query: 1370 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1429
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1438 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1495
Query: 1430 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1489
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1496 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1555
Query: 1490 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1549
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1556 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1615
Query: 1550 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1609
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1616 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1675
Query: 1610 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1669
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1676 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1735
Query: 1670 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1729
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1736 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1795
Query: 1730 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1789
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1796 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1855
Query: 1790 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1849
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1856 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1915
Query: 1850 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1916 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1952
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 3566 bits (9247), Expect = 0.0
Identities = 1812/1957 (92%), Positives = 1826/1957 (93%), Gaps = 93/1957 (4%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
Query: 1370 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1429
PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1419 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1478
Query: 1430 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1489
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1479 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1538
Query: 1490 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1549
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1539 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1598
Query: 1550 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1609
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1599 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1658
Query: 1610 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1669
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1659 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1718
Query: 1670 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1729
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1719 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1778
Query: 1730 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1789
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1779 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1838
Query: 1790 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1849
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1839 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1898
Query: 1850 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1899 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1935
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 3555 bits (9218), Expect = 0.0
Identities = 1809/1957 (92%), Positives = 1823/1957 (93%), Gaps = 96/1957 (4%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1415
Query: 1370 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1429
PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1416 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1475
Query: 1430 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1489
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1476 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1535
Query: 1490 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1549
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1536 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1595
Query: 1550 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1609
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1596 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1655
Query: 1610 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1669
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1656 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1715
Query: 1670 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1729
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1716 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1775
Query: 1730 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1789
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1776 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1835
Query: 1790 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1849
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1836 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1895
Query: 1850 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1896 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1932
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 3509 bits (9099), Expect = 0.0
Identities = 1791/1957 (91%), Positives = 1806/1957 (92%), Gaps = 113/1957 (5%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
Query: 1370 PPPGAHLYEELGDSSMHNLFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1429
PPPGAHLYEELGDSS+ LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV
Sbjct: 1401 PPPGAHLYEELGDSSI--LFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHV 1458
Query: 1430 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1489
DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA
Sbjct: 1459 DGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQA 1518
Query: 1490 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1549
KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK
Sbjct: 1519 KSKSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNK 1578
Query: 1550 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1609
RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS
Sbjct: 1579 RGSSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVS 1638
Query: 1610 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1669
RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP
Sbjct: 1639 RTVELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPP 1698
Query: 1670 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1729
NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL
Sbjct: 1699 NISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPL 1758
Query: 1730 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1789
SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI
Sbjct: 1759 SVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKI 1818
Query: 1790 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1849
KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM
Sbjct: 1819 KSSMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTM 1878
Query: 1850 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1886
CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Sbjct: 1879 CPSEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL 1915
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 2607 bits (6756), Expect = 0.0
Identities = 1334/1457 (91%), Positives = 1348/1457 (92%), Gaps = 71/1457 (4%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1370 PPPGAHLYEELGDSSMH 1386
PPPGAHLYEELGDSSMH
Sbjct: 1441 PPPGAHLYEELGDSSMH 1457
Score = 31.2 bits (69), Expect = 10.0
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764
P P +P P P PPPPP PPPP A
Sbjct: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 2607 bits (6756), Expect = 0.0
Identities = 1334/1457 (91%), Positives = 1348/1457 (92%), Gaps = 71/1457 (4%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I T
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 LGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN------ 633
+ + + +S R+ +L + A+D D + A N
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 634 ------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA------ 663
I++ +D P N+ V + NA
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 664 --------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 709
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 950 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1009
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1190 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1250 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1309
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1310 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1369
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1370 PPPGAHLYEELGDSSMH 1386
PPPGAHLYEELGDSSMH
Sbjct: 1441 PPPGAHLYEELGDSSMH 1457
Score = 31.2 bits (69), Expect = 10.0
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764
P P +P P P PPPPP PPPP A
Sbjct: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 2600 bits (6740), Expect = 0.0
Identities = 1334/1462 (91%), Positives = 1348/1462 (92%), Gaps = 76/1462 (5%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 416 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 476 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 536 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERS 595
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 596 TGILTLGKAL---DRESTDRY------------------ILIITASDGRPDGTSTATVN- 633
I T+ + + +S R+ +L + A+D D + A N
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 634 -----------------------------IVVTDVNDNAPVFDPYLPRNLSVVEEEANA- 663
I++ +D P N+ V + NA
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 664 -------------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 704
FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 705 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 764
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 765 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 825 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 885 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 944
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 945 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1004
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1005 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1064
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1065 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1124
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1125 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1184
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1185 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1244
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1245 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1304
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1305 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1364
ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1365 PPPPPPPPGAHLYEELGDSSMH 1386
PPPPPPPPGAHLYEELGDSSMH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMH 1462
Score = 31.2 bits (69), Expect = 10.0
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764
P P +P P P PPPPP PPPP A
Sbjct: 1425 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1450
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 2593 bits (6722), Expect = 0.0
Identities = 1334/1469 (90%), Positives = 1348/1469 (91%), Gaps = 83/1469 (5%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
Query: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
Query: 589 APPAERSTGILTLGKAL---DRESTDRY------------------ILIITASDGRPDGT 627
APPAER I T+ + + +S R+ +L + A+D D
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
Query: 628 STATVN------------------------------IVVTDVNDNAPVFDPYLPRNLSVV 657
+ A N I++ +D P N+ V
Sbjct: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Query: 658 EEEANA--------------------FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 697
+ NA FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
Query: 698 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 757
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
Query: 758 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 817
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
Query: 818 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 877
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
Query: 878 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 937
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
Query: 938 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 997
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
Query: 998 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1057
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Query: 1058 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1117
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
Query: 1118 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1177
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
Query: 1178 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1237
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
Query: 1238 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1297
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
Query: 1298 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1357
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
Query: 1358 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1386
PAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMH 1469
Score = 31.2 bits (69), Expect = 10.0
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764
P P +P P P PPPPP PPPP A
Sbjct: 1432 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1457
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 306 bits (785), Expect = 9e-83
Identities = 284/1075 (26%), Positives = 468/1075 (43%), Gaps = 136/1075 (12%)
Query: 103 LDRDPPMNIH-SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKH-ESYYATVNELT 160
LDR+ I +I + Q ++ KV Y ++ + + D ND P F E Y +V E
Sbjct: 540 LDRELASQIVLNISARDQGVHPKVS---YAQLVVTLLDVNDEKPVFSQPEGYDVSVVENA 596
Query: 161 PVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRL 220
P GT + ATD D G NG + + +Q + T +F + ++G + L
Sbjct: 597 PTGTELLM-----LRATDGDLGDNGTVRFSLQ---EAETDRRSFRLD-PVSGRLSTISSL 647
Query: 221 NYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP- 279
+ E++ Y +++ A D + +++ + V +LD +D P+F P + ++ P
Sbjct: 648 DREEQAFYSLLVLATDLG---SPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPG 704
Query: 280 ----LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
T A P+L T + YSI G D
Sbjct: 705 GSYITTVSATDPDLGT---------------------------NGTVKYSISAG---DRS 734
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
RF ++ ++ +S ++R+ + L I A P A + I +LD + P F
Sbjct: 735 RF-QVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVF 793
Query: 396 TMPSYQGYILESAP----VGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
+ +Y + E+ VG+ + +++L S + + + D +
Sbjct: 794 SQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYL---------------ITTGDQKGM 838
Query: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
F + Q +T LT +DREEQ Y + A G + +VNI V D NDN+P F +
Sbjct: 839 FAINQ--VTGQLTTANVIDREEQSFYQLKVVASGGTVTGD-TMVNITVKDLNDNSPHFLQ 895
Query: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 571
V V + + G S+ Q AVD DEG NG + Y + + F IN+ G I++ +
Sbjct: 896 AIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPL 955
Query: 572 EMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 631
++ G +Y + + A+D P S+ ILT
Sbjct: 956 DVHAG-SYQIEILASDMGVPQLSSSVILT------------------------------- 983
Query: 632 VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFN 689
+ V DVNDN+PVFD E N+ +V+A+D D+G NG++ Y++ GN
Sbjct: 984 --VYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTG 1041
Query: 690 NLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 749
+ F I +G +Y +L+RE++D Y L+VVA+D AV P +T+ + + + D++DN P+F
Sbjct: 1042 DAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFN 1101
Query: 750 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 809
++ YT EE AG+ + ++ A D D G N R V+ F LH +GE++
Sbjct: 1102 STNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQF 1161
Query: 810 DYEAFPDQEASITFLVEAFDIYGTMPPGI---ATVTVIVKDMNDYPPVFSKRIYKGMVAP 866
D E+ + + F +P + ATV V +KD+ND P F K Y+ ++
Sbjct: 1162 DRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISE 1221
Query: 867 DAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 924
A T + V A D D GL + ++ Q F ++ SG+V L+
Sbjct: 1222 SAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQ-------FAIDSTSGQVTLIGKLD 1274
Query: 925 EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMV 984
E T + LV+ A D G ++S+ T+ I +L + + V E G +V
Sbjct: 1275 YEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELV 1334
Query: 985 GVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADS 1040
++A + N + YSI N TF I+ TG I++ LD+ET++ Y L + A
Sbjct: 1335 SSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITA-- 1392
Query: 1041 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1100
+ P +S+T V I ++D N++PP F + E+ + TSV+ V A D
Sbjct: 1393 -----KDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDP 1447
Query: 1101 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1155
D ++Y II + G F ++ G I T + F+ V A D
Sbjct: 1448 DADINGQLSY-TIIQQMPRGNH-FTIDEVKGTIYTNAEIDREFANLFELTVKAND 1500
Score = 285 bits (729), Expect = 3e-76
Identities = 282/1078 (26%), Positives = 465/1078 (43%), Gaps = 147/1078 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
+ I V D ND++P F Y + E T G+ + ATD D G NG+I Y++
Sbjct: 1827 INITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAIL-----ATDDDSGVNGEITYIV- 1880
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
N DD D +TG L + L+YE + Y + ++A D TT +
Sbjct: 1881 -NEDD---EDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQF-----TTIRVY 1931
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
++LD +D P+F + + L + ++ + D N
Sbjct: 1932 FNILDVNDNPPIF---------------SLNSYSTSLMENLPVGSTVLVFNVTDADDGIN 1976
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
Q + YSI G + +F + L +L+ ++R+ ++LV++
Sbjct: 1977 SQ-------LTYSIASG--DSLGQF--TVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQ 2025
Query: 373 HPLPAF---AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
P F A + I +LD N+ P F P YI E+ P+ + + A
Sbjct: 2026 IPASRFTSTAQVSIILLDVNDNPPTFLSPKLT-YIPENTPIDTVV---------FKAQAT 2075
Query: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
D D E L LN + F++ I + L +DREE YT ++ A D Q
Sbjct: 2076 DPDSGPNSYIEYTL-LNPLGNKFSIGT--IDGEVRLTGELDREEVSNYTLTVVATDKGQP 2132
Query: 490 S--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
S V + V+D NDN P F + Y V + + G +IQ+ A D DEG+NG++ Y
Sbjct: 2133 SLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYG 2192
Query: 548 ILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALD 606
I+ G +F I+ TG IT+A K LD
Sbjct: 2193 IVNGNTNQEFRIDSVTGAITVA----------------------------------KPLD 2218
Query: 607 RESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD--PY---LPRNLSVVEEE 660
RE T Y L + A+D G T T+TV+IV+ D+ND PVF+ PY +P NL +
Sbjct: 2219 REKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT 2278
Query: 661 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVV 718
+ QV A D D G N ++ Y L GN +N F ++++G + L+RE ++ + L++
Sbjct: 2279 ----ILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMI 2334
Query: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 778
ATD T T+ + V D++DN P F + Y + E+ P GT +L + A D D
Sbjct: 2335 TATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS 2394
Query: 779 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 838
N RI + F ++P TG++ LD E + + T +V D P
Sbjct: 2395 KNAVIRIIGGNSQ--FTINPSTGQIITSALLDRET----KDNYTLVVVCSDAGSPEPLSS 2448
Query: 839 AT-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 897
+T V V V D+ND PP F Y + + G+ + V DAD P S + Y +
Sbjct: 2449 STSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIG--PNSELHYSLS 2506
Query: 898 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH 957
+ F ++ G ++ LN F + V D G + S TV + ++
Sbjct: 2507 GRN----SEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVN 2560
Query: 958 PGEIPRFTQEEY-----RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGIN 1012
+ P+ +E PVS L T + ++ + + Y I SGN +TF I+
Sbjct: 2561 KADFPKVRAKEQTFMFPENQPVSSLVTT-----ITGSSLRGEPMSYYIASGNLGNTFQID 2615
Query: 1013 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1072
+TG + ++ PLD+E YV+ ++A + P S+ K+ I + D N++ P+
Sbjct: 2616 QLTGQVSISQPLDFEKIQKYVVWIEA-------RDGGFPPFSSYEKLDITVLDVNDNAPI 2668
Query: 1073 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1132
F++ +I + E+ +L V A DKD+G + Y ++ + + F + TG
Sbjct: 2669 FKEDPFISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNM---ENSFSINHATGE 2724
Query: 1133 IKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD-----MQVIVSNVP 1185
I++ + S++ + ++D S V+++++++ D Q+ ++VP
Sbjct: 2725 IRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782
Score = 271 bits (694), Expect = 3e-72
Identities = 306/1143 (26%), Positives = 503/1143 (44%), Gaps = 150/1143 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 191
V I VRD NDN P+F + ++ E P+GT++ + + D A DI NGQ+ Y +I
Sbjct: 1406 VVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDA-DI----NGQLSYTII 1460
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Q P + F I + G I ++ E + + ++AND+A + RR +
Sbjct: 1461 QQMP----RGNHFTID-EVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNV 1515
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
T+ V D +D PMF+ + AA P L I+ P + + +
Sbjct: 1516 TILVTDLNDNVPMFISQNAL------------AADPSAVIGSVLTTIMAADPDEGANGE- 1562
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
I Y I+ G + F + + +L + + ++L++ A D
Sbjct: 1563 ----------IEYEIINGDTDT----FIVDRYSGDLRVASALVPS-QLIYNLIVSAT-DL 1606
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA-LD 430
G P + + I+ + P FT P Y + E P+G + S+ SP A ++
Sbjct: 1607 G-PERRKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVI-SIEAASPRGSEAPVE 1664
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDREEQQT-YTFSI------T 482
I + E +FT+ + TGI + +L DRE+ Y + T
Sbjct: 1665 YYIVSVRCEE-----KTVGRLFTIGRHTGIIQTAAIL---DREQGACLYLVDVYAIEKST 1716
Query: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
AF Q +E V I + D NDN P FP D+ V ++ G ++QLTA+DADEG+N
Sbjct: 1717 AFPRTQRAE---VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANA 1773
Query: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLG 602
+TY I+ GA F I + +G L
Sbjct: 1774 LVTYTIISGADDSFRI----------------------------------DPESGDLIAT 1799
Query: 603 KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-A 661
+ LDRE +Y L++ A DG +S +NI V+DVND+ P F + + + E+
Sbjct: 1800 RRLDRERRSKYSLLVRADDGLQ--SSDMRINITVSDVNDHTPKFSRPV-YSFDIPEDTIP 1856
Query: 662 NAFVGQVKATDPDAGINGQVHYSLG--NFNNLFRITSNGSIYTAVK-LNREVRDYYELVV 718
+ V + ATD D+G+NG++ Y + + + +F + ++ + L+ EV+ YY L V
Sbjct: 1857 GSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTV 1916
Query: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 778
A DG + +T+ + +LD++DN P+F+ ++Y+ + ENLP G+T+L D D G
Sbjct: 1917 RAEDGG--GQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDG 1974
Query: 779 AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD---IYGT 833
N ++Y I S + F + G L +L++LD E+ ++ +V+ D I +
Sbjct: 1975 INSQLTYSIASGDSLGQFTVDK-NGVLKVLKALDRES----QSFYNLVVQVHDLPQIPAS 2029
Query: 834 MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY--AEDADPPGLPASR 891
A V++I+ D+ND PP F K P+ TPI TV A+ DP P S
Sbjct: 2030 RFTSTAQVSIILLDVNDNPPTFLSP--KLTYIPE---NTPIDTVVFKAQATDPDSGPNSY 2084
Query: 892 VRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 951
+ Y + + + F + G V L+ E + + L VVA D G+P +SSS V
Sbjct: 2085 IEYTLLNPL----GNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEV 2140
Query: 952 KILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEE 1006
++VL + P F Q Y+ ++E GT + + AA N + Y IV+GN
Sbjct: 2141 VVMVLDINDNNPIFAQALYK-VEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTN 2199
Query: 1007 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
F I+++TG I V PLD E +Y L VQA + +++T+ V I + D
Sbjct: 2200 QEFRIDSVTGAITVAKPLDREKTPTYHLTVQA-------TDRGSTPRTDTSTVSIVLLDI 2252
Query: 1067 NNHPPVFQKKFYIGGVSED-ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV 1125
N+ PVF+ Y V E+ + ++L+V A D D G+ S ++Y L ++
Sbjct: 2253 NDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVL----FGGNEDNAF 2308
Query: 1126 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA--DVLVSVVNQLDMQVIVSN 1183
+ +G + + F + ATD L+G +V+V VN ++ S
Sbjct: 2309 TLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVND-NVPTFASK 2367
Query: 1184 VPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAID 1243
T + + T++L + V+ IG F++ T +T +D
Sbjct: 2368 AYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGG---NSQFTINPSTGQIITSALLD 2424
Query: 1244 PQT 1246
+T
Sbjct: 2425 RET 2427
Score = 271 bits (693), Expect = 4e-72
Identities = 278/968 (28%), Positives = 421/968 (43%), Gaps = 147/968 (15%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
T +LDR+ ++ +V V I K EV I ++D NDN P F + TV
Sbjct: 1692 TAAILDREQGACLY--LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749
Query: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
E G+ I A D D+G N + Y I DD D +G+++
Sbjct: 1750 EENIGDGSKIM-----QLTAMDADEGANALVTYTIISGADDSFRIDP------ESGDLIA 1798
Query: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
+RL+ E +++Y ++++A+D Q+ + R + + V D +D P F
Sbjct: 1799 TRRLDRERRSKYSLLVRADDGLQSSDMR------INITVSDVNDHTPKF----------- 1841
Query: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
RP+ Y IPE P L I A D D + I Y + +D
Sbjct: 1842 SRPV-YSFDIPEDTIPGSL-----VAAILATDDDSGVNGE-----ITYIV---NEDDEDG 1887
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
F ++P T +L ++ + Q + L ++AE G ++ ILD N+ P F+
Sbjct: 1888 IFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFS 1945
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL--HLFLNDYTSVFTV 454
+ SY ++E+ PVG+T+ +V D +D + +L + D FTV
Sbjct: 1946 LNSYSTSLMENLPVGSTV-----------LVFNVTDADDGINSQLTYSIASGDSLGQFTV 1994
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFD-----GVQESEPVIVNIQVMDANDNTPTF 509
+ G+ L +L+ +DRE Q Y + D + + V+I ++D NDN PTF
Sbjct: 1995 DKNGV---LKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 2051
Query: 510 --PEISYDVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
P+++Y + P D+V+ + A D D G N I Y +L F I G +
Sbjct: 2052 LSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVR 2107
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
+ ++ Y LTV A D G+P
Sbjct: 2108 LTGELDREEVSNYTLTVVATDK---------------------------------GQPSL 2134
Query: 627 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVH 682
+S+ V ++V D+NDN P+F + L VE N G QV A D D G NGQV
Sbjct: 2135 SSSTEVVVMVLDINDNNPIF----AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVR 2190
Query: 683 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 739
Y + GN N FRI S G+I A L+RE Y L V ATD PR T T++I +L
Sbjct: 2191 YGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLL 2250
Query: 740 DIDDNSPVFTNSTYTVLVEENLPAGT---TILQIEAKDVDLGAN--VSYRIRSPEVKHFF 794
DI+D PVF S Y+V V ENL GT TILQ+ A+D D G+N +SY + + F
Sbjct: 2251 DINDFVPVFELSPYSVNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAF 2308
Query: 795 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 854
L +GEL + +SLD E + ++ A D G T+ VIV D+ND P
Sbjct: 2309 TLSA-SGELGVTQSLDRET----KERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT 2363
Query: 855 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 914
F+ + Y + DA GT + V A DAD AS+ ++ S F + +
Sbjct: 2364 FASKAYFTTIPEDAPTGTDVLLVNASDAD-----ASKNAV----IRIIGGNSQFTINPST 2414
Query: 915 GRVITRVNLNEEPTTIFKLVVVAFDDGEP-VMSSSATVKILVLHPGEIPRFTQEEYRPPP 973
G++IT L+ E + LVVV D G P +SSS +V + V + P Q
Sbjct: 2415 GQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTH 2474
Query: 974 VSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETR 1029
+ G+ V ++ N + YS+ SG + F I+ + G I GPL+ +
Sbjct: 2475 IPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIMAAGPLNGASE 2533
Query: 1030 TSYVLRVQ 1037
++ + V+
Sbjct: 2534 VTFSVHVK 2541
Score = 256 bits (654), Expect = 1e-67
Identities = 279/1072 (26%), Positives = 464/1072 (43%), Gaps = 139/1072 (12%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Y ++ I V D NDN+P FK + + + + E L+P I T A D D GPNGQ++
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTV-----SAMDKDSGPNGQLD 2704
Query: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Y I + ++F I TG I + L+ E + Y + I+++D+ + ++T+
Sbjct: 2705 YEIV----NGNMENSFSIN-HATGEIRSVRPLDREKVSHYVLTIKSSDKG---SPSQSTS 2756
Query: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
+ +++LD +D P F + A +PE +P VT D
Sbjct: 2757 VKVMINILDENDNAPRFSQI-------------FSAHVPE-NSPLGYTVTRVTTS----D 2798
Query: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
+D I S YSI+ D F ++P T ++ + P+NR+ ++ + + A
Sbjct: 2799 EDIGINAISR-----YSIM-----DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH 2848
Query: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
D+G + + I + D N+ +P F+ SY E +G+ ++ ++ A
Sbjct: 2849 -DSGWTVST--DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVT---------QVFA 2896
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTG---ITRYLTLLQPV---DREEQQTYTFSIT 482
D D + + ++ F+ + F + T + + Q V ++F +T
Sbjct: 2897 TDPD--EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVT 2954
Query: 483 AFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEG 539
+ D + S V I ++D+NDN P F + Y V +++ G +I++TA+D D G
Sbjct: 2955 SSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFG 3014
Query: 540 SNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGI 598
N E+ Y I G F ++ TG I++A
Sbjct: 3015 LNSEVEYFISNDNHLGKFKLDNDTGWISVA------------------------------ 3044
Query: 599 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
+L + + + +TA D G P +S ATV+I VT+ N + P F
Sbjct: 3045 ----SSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPE 3100
Query: 658 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYY 714
+ V V A D DA +NG + YS+ GN +F I S+ I T K L+ E+ +
Sbjct: 3101 SHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKH 3160
Query: 715 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 774
E+ + A DG R ++ + V+D++DNSPVF + Y V EN P+GTT++ + A D
Sbjct: 3161 EMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATD 3220
Query: 775 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 832
D G N ++Y ++S + F + P TG ++ LD+E + S V+AF++
Sbjct: 3221 ADSGTNAVIAYTVQSSD-SDLFVIDPNTGVITTQGFLDFET----KQSYHLTVKAFNVPD 3275
Query: 833 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 892
ATV + +K N+Y P F ++Y ++ A KGT + V+A D D V
Sbjct: 3276 EERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLG--TDGEV 3333
Query: 893 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA--FDDGEPVMSSSAT 950
Y + F++ + +G++ L+ E L V+A F T
Sbjct: 3334 HYLIFGNS---RKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVT 3390
Query: 951 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-----QSIVYSIVSGNE 1005
V + VL + P FT Y +SE GT V +SA + Y I SGNE
Sbjct: 3391 VNVTVLDANDPPIFTLNIY-SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNE 3449
Query: 1006 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1065
F IN TG I V LD ET Y +L V+ + PS + +A + + ++D
Sbjct: 3450 NGAFSINPQTGQITVTAELDRETLPIY-------NLSVLAVDSGTPSATGSASLLVTLED 3502
Query: 1066 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD-TGNYSVMAYRLIIPPIKEGKEGF 1124
N++ P+ G V E+ R T V+ +++TD D N Y L+ F
Sbjct: 3503 INDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLL--STGPATSYF 3558
Query: 1125 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+ T G++ T + + F V+ D +S V ++V++Q D
Sbjct: 3559 SLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609
Score = 254 bits (648), Expect = 7e-67
Identities = 280/1058 (26%), Positives = 441/1058 (41%), Gaps = 139/1058 (13%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
Y +V + V+D NDN P F Y A V E VG+++ A D D+G N I Y
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL-----QVAAADADEGTNADIRY 287
Query: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
+Q + P D TG I +R+ L++E + +Y + +QA DR R
Sbjct: 288 RLQ-DEGTPFQMDP------ETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEAL 340
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
+DV D D P+ P ++ + A+
Sbjct: 341 IQLLDVNDND-------------------PVVKFRYFPATSRYASVDENAQVGTVVALLT 381
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMH----PRTAELSLLEPVNRDFHQKFDLVI 365
+ P+ I IL G + R F + P + + + ++R+ ++L +
Sbjct: 382 VTDADSPAANGNISVQILGGNEQ---RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTV 438
Query: 366 KAEQDNGHPLPA-------FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 418
+ G P A A L I + D N+ P F+ Y+ + E AP G+ +S
Sbjct: 439 SVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG-- 496
Query: 419 NLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
I A D D + + + F +++ +DRE
Sbjct: 497 -------ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIV 549
Query: 479 FSITAFDGVQESEPVI----VNIQVMDANDNTPTF--PEISYDVYVYTDMRPGDSVIQLT 532
+I+A D Q P + + + ++D ND P F PE YDV V + G ++ L
Sbjct: 550 LNISARD--QGVHPKVSYAQLVVTLLDVNDEKPVFSQPE-GYDVSVVENAPTGTELLMLR 606
Query: 533 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
A D D G NG + + L A+ D R++ L
Sbjct: 607 ATDGDLGDNGTVRFS-LQEAETD--------------------RRSFRL----------- 634
Query: 593 ERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP 651
+ +G L+ +LDRE Y L++ A+D G P +S A +N+ + D+NDN+PVF P
Sbjct: 635 DPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQY 694
Query: 652 RNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNRE 709
E +++ V ATDPD G NG V YS+ G+ + +G I T + L+RE
Sbjct: 695 FAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDRE 754
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
+ Y+L +VATDG + + I VLD DN PVF+ Y+ +V EN+ G +
Sbjct: 755 EKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGS 814
Query: 770 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
+ A +DL +N+SY I + + K FA++ TG+L+ + D+E + ++
Sbjct: 815 VSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVI------DREEQSFYQLKVVA 868
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
GT+ G V + VKD+ND P F + I V + G I A+ DP
Sbjct: 869 SGGTV-TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSI--FQAKAVDPDEGVN 925
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
V Y + P ++F + E +G + L+ + +++ ++A D G P +SSS
Sbjct: 926 GMVLYSLKQ----NPKNLFAINEKNGTISLLGPLDVHAGS-YQIEILASDMGVPQLSSSV 980
Query: 950 TVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1004
+ + V + P F Q Y +SE + + A + N I Y+I GN
Sbjct: 981 ILTVYVHDVNDNSPVFDQLSYE-VTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGN 1039
Query: 1005 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1064
D FGI G +Y+ LD E + YVL VV ++ V S T V + ++
Sbjct: 1040 TGDAFGIFP-DGQLYIKSELDRELQDRYVLM-------VVASDRAVEPLSATVNVTVILE 1091
Query: 1065 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL-IIPPIKEGKEG 1123
D N++ P+F Y E+ R + V +V A DKD G + Y ++ P
Sbjct: 1092 DVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQP------D 1145
Query: 1124 FVVETYTGLIKTAMLFHN---MRR---SYFKFQVIATD 1155
F + +G I F MRR + F F VIATD
Sbjct: 1146 FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATD 1183
Score = 249 bits (636), Expect = 2e-65
Identities = 283/1102 (25%), Positives = 464/1102 (42%), Gaps = 147/1102 (13%)
Query: 91 KQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHE---VRIVVRDRNDNSPTF 147
K + +N + P+++H+ Q++ + +G + + V D NDNSP F
Sbjct: 937 KNLFAINEKNGTISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVF 996
Query: 148 KHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP 207
SY T++E PV + F A+D D G NG+I Y I + + D F I
Sbjct: 997 DQLSYEVTLSESEPVNSRFFKV-----QASDKDSGANGEIAYTIA----EGNTGDAFGI- 1046
Query: 208 LMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLP 267
G + ++ L+ E + RY +++ A+DRA E + T +TV + D +D P+F
Sbjct: 1047 -FPDGQLYIKSELDRELQDRYVLMVVASDRAV---EPLSATVNVTVILEDVNDNRPLF-- 1100
Query: 268 CVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSIL 327
+ EE + A+D+D P + + YS
Sbjct: 1101 ---------------NSTNYTFYFEEEQRAGSFVGKVSAVDKD--FGPNGE---VRYSFE 1140
Query: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK------FDL-VIKAEQDNGHPLPAFAG 380
+ P+ F +H + E++ +R+ + F VI +Q PL A
Sbjct: 1141 MVQPD-----FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQAT 1195
Query: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 440
+H+ + D N+ +P F YQ I ESA NLT LR+ A D D +
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAA---------NLTQVLRVSASDVDEGNNGLIH 1246
Query: 441 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQ 498
+ + F + T + +TL+ +D E Y+ I A D + + +NI
Sbjct: 1247 YSIIKGNEERQFAIDST--SGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNID 1304
Query: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGDFI 557
++D NDNTP+FP+ + V V +MR G+ V +TA D+D G N ++ Y I G F
Sbjct: 1305 ILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFS 1364
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILII 617
I+ TG I +A ++ Y L + A D
Sbjct: 1365 ISPNTGSIFLAKKLDFETQSLYKLNITAKD------------------------------ 1394
Query: 618 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGI 677
GRP +ST +V I V D NDN P F P V V V A DPDA I
Sbjct: 1395 ---QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADI 1451
Query: 678 NGQVHYSL------GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAV---HPR 728
NGQ+ Y++ GN + + G+IYT +++RE + +EL V A D AV R
Sbjct: 1452 NGQLSYTIIQQMPRGNHFTIDEV--KGTIYTNAEIDREFANLFELTVKANDQAVPIETRR 1509
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 786
++ + I V D++DN P+F S + + + G+ + I A D D GAN + Y I
Sbjct: 1510 YALKNVTILVTDLNDNVPMFI-SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEII 1568
Query: 787 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 846
+ + F + ++G+L + +L P Q +V A D+ +T+I++
Sbjct: 1569 NGDTDTFI-VDRYSGDLRVASAL----VPSQ-LIYNLIVSATDLGPERRKSTTELTIILQ 1622
Query: 847 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP-- 904
++ PVF++ Y ++ GT + ++ E A P G A V Y + V+
Sbjct: 1623 GLDG--PVFTQPKYITILKEGEPIGTNVISI--EAASPRGSEAP-VEYYIVSVRCEEKTV 1677
Query: 905 ASIFEVEEDSGRVITRVNLNEEPTTIFKLV-VVAFDDGEPV-MSSSATVKILVLHPGEIP 962
+F + +G + T L+ E LV V A + + A V+I + + P
Sbjct: 1678 GRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNP 1737
Query: 963 RFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVI 1018
+ V E G+ + ++A N + Y+I+SG +D+F I+ +G +
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDL 1796
Query: 1019 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1078
LD E R+ Y L V+AD +S+ ++ I + D N+H P F + Y
Sbjct: 1797 IATRRLDRERRSKYSLLVRADD----------GLQSSDMRINITVSDVNDHTPKFSRPVY 1846
Query: 1079 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAM 1137
+ ED + V + ATD D+G + Y + ++ ++G F + TG+
Sbjct: 1847 SFDIPEDTIPGSLVAAILATDDDSGVNGEITYIV----NEDDEDGIFFLNPITGVFNLTR 1902
Query: 1138 LFHNMRRSYFKFQVIATDDYGK 1159
L + Y+ V A D G+
Sbjct: 1903 LLDYEVQQYYILTVRAEDGGGQ 1924
Score = 247 bits (631), Expect = 7e-65
Identities = 273/1012 (26%), Positives = 430/1012 (42%), Gaps = 146/1012 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V +++ D NDN P F +Y E G+ F G A D D GPNG++ Y +
Sbjct: 1086 VTVILEDVNDNRPLFNSTNYTFYFEEEQRAGS-----FVGKVSAVDKDFGPNGEVRYSFE 1140
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY-------FVIIQANDRAQNLNERR 245
D FE+ ++G I + + E R F +I + Q + +
Sbjct: 1141 MVQPD------FELHA-ISGEITNTHQFDRESLMRRRGTAVFSFTVIATD---QGIPQPL 1190
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
T+ V + D +D P FL YQA I E + L ++ +
Sbjct: 1191 KDQATVHVYMKDINDNAPKFLKDF------------YQATISE--SAANLTQVL---RVS 1233
Query: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
A D D + I YSI+ G E R F + + +++L+ ++ + + LVI
Sbjct: 1234 ASDVDEG-----NNGLIHYSIIKGNEE---RQFAIDSTSGQVTLIGKLDYEATPAYSLVI 1285
Query: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
+A PL + L+I+ILDEN+ +P F + +LE+ +G +S
Sbjct: 1286 QAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSS--------- 1336
Query: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
+ A D D D D + + F+++ T + L + +D E Q Y +ITA D
Sbjct: 1337 VTATDSDSGDNADLYYSITGTNNHGTFSISPN--TGSIFLAKKLDFETQSLYKLNITAKD 1394
Query: 486 GVQ--ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
+ S + V I V D NDN P+FP + ++ G SVI +TA D D NG+
Sbjct: 1395 QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQ 1454
Query: 544 ITYEIL--VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTL 601
++Y I+ + F I++ G I ++ + LTV+A D A P E
Sbjct: 1455 LSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIE-------- 1506
Query: 602 GKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 661
T RY L V I+VTD+NDN P+F + +N + A
Sbjct: 1507 --------TRRYAL--------------KNVTILVTDLNDNVPMF---ISQNALAADPSA 1541
Query: 662 --NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELV 717
+ + + A DPD G NG++ Y + G+ + +G + A L + Y L+
Sbjct: 1542 VIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPS-QLIYNLI 1600
Query: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 777
V ATD R ST L I + +D PVFT Y +++E P GT ++ IEA
Sbjct: 1601 VSATDLGPERRKSTTELTIILQGLD--GPVFTQPKYITILKEGEPIGTNVISIEAAS-PR 1657
Query: 778 GAN-------VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 830
G+ VS R V F + TG + LD E + + +LV+ + I
Sbjct: 1658 GSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDRE-----QGACLYLVDVYAI 1712
Query: 831 -YGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD--PP 885
T P A V + ++D+ND PPVF + V + G+ I + A DAD
Sbjct: 1713 EKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGAN 1772
Query: 886 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 945
L + DD F ++ +SG +I L+ E + + L+V A DDG +
Sbjct: 1773 ALVTYTIISGADD--------SFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDG--LQ 1821
Query: 946 SSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSI 1000
SS + I V + P+F++ Y + E G++V I A + +N I Y +
Sbjct: 1822 SSDMRINITVSDVNDHTPKFSRPVY-SFDIPEDTIPGSLVAAILATDDDSGVNGEITYIV 1880
Query: 1001 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1060
+E+ F +N ITGV + LDYE + Y+L V+A+ + T +VY
Sbjct: 1881 NEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAED---------GGGQFTTIRVY 1931
Query: 1061 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112
I D N++PP+F Y + E+ + ++VL TD D G S + Y +
Sbjct: 1932 FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSI 1983
Score = 247 bits (631), Expect = 7e-65
Identities = 305/1238 (24%), Positives = 498/1238 (40%), Gaps = 183/1238 (14%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
T +LDR+ N +++VV V + V D NDN P F+H Y +
Sbjct: 2419 TSALLDRETKDN-YTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPS 2477
Query: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
T G+ +F TD D GPN ++ Y + +++ F I L G I+
Sbjct: 2478 PTLPGSFVFAVT-----VTDADIGPNSELHYSLSGR-----NSEKFHID-PLRGAIMAAG 2526
Query: 219 RLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCR 278
LN + + V ++ +T +TT+TV ++
Sbjct: 2527 PLNGASEVTFSVHVKDGGSFP-----KTDSTTVTVRFVN--------------------- 2560
Query: 279 PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY---- 334
+A P++R E+ P+ ++ I S L G P Y
Sbjct: 2561 ----KADFPKVRAKEQTFMFPENQPVSSLVTT-----------ITGSSLRGEPMSYYIAS 2605
Query: 335 ---PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQ 391
F + T ++S+ +P++ + QK+ + I+A P ++ L I +LD N+
Sbjct: 2606 GNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDN 2665
Query: 392 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
+P F + ILE+ L+ L + A+DKD + + + +
Sbjct: 2666 APIFKEDPFISEILEN----------LSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENS 2715
Query: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTF 509
F++ T + ++P+DRE+ Y +I + D +S V V I ++D NDN P F
Sbjct: 2716 FSINHA--TGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF 2773
Query: 510 PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAP 569
+I + +V + G +V ++T D D G N Y I+ A F IN +TG I I+
Sbjct: 2774 SQI-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM-DASLPFTINPSTGDIVIS- 2830
Query: 570 GVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTST 629
+ L+RE TDRY + ++A D T +
Sbjct: 2831 ---------------------------------RPLNREDTDRYRIRVSAHDS--GWTVS 2855
Query: 630 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN 689
V I VTD+NDNAP F E + V QV ATDPD G NGQV Y + + +
Sbjct: 2856 TDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS 2915
Query: 690 NLFRITSNGSIYTAVKLNREVRDY-------------YELVVVATDGAVHPRHSTLTLAI 736
FRI + T N+++ Y + +V ++D S T+ I
Sbjct: 2916 EYFRINAT----TGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTI 2971
Query: 737 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA---KDVDLGANVSYRIRSPEVKHF 793
++D +DN+P F S Y V +N+ GT ++++ A KD L + V Y I +
Sbjct: 2972 NIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGK 3031
Query: 794 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP 853
F L TG +S+ SL D + V A D ATV + V + N + P
Sbjct: 3032 FKLDNDTGWISVASSL----ISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTP 3087
Query: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 913
FS+ + G+ + TV A D D ++Y + IF +
Sbjct: 3088 EFSQSHMSATIPESHSIGSIVRTVSARDRD--AAMNGLIKYSISSGN---EEGIFAINSS 3142
Query: 914 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPP 972
+G + L+ E ++ + A D G + +V + V+ + P F ++Y P
Sbjct: 3143 TGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYF-P 3201
Query: 973 PVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1028
V E A GT V ++A + N I Y++ S ++ D F I+ TGVI G LD+ET
Sbjct: 3202 TVLENAPSGTTVIHLNATDADSGTNAVIAYTVQS-SDSDLFVIDPNTGVITTQGFLDFET 3260
Query: 1029 RTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1088
+ SY L V+A N+ + + A V I+++ N + P F K Y +SE A
Sbjct: 3261 KQSYHLTVKA-------FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPK 3313
Query: 1089 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1148
T V V A+D+D G + Y + K+GF + TG I + + +
Sbjct: 3314 GTIVGEVFASDRDLGTDGEVHYLIF---GNSRKKGFQINKKTGQIYVSGILDREKEERVS 3370
Query: 1149 FQVIATDDYGKGLSGKAD---VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEI--LDRY 1203
+V+A ++G D V V+V++ D + N+ + + + T + + +
Sbjct: 3371 LKVLA-KNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAF 3429
Query: 1204 VQEQIPGAKVVVESIGARRHGDAFSLEDYTK---------------CDLTVYAIDPQTNR 1248
+ IP IG+ AFS+ T +L+V A+D T
Sbjct: 3430 DSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPS 3489
Query: 1249 AIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTP 1286
A L L+ DIN + G ++E + P
Sbjct: 3490 ATGSASLLVTLE----DINDNGPMLTVSEGEVMENKRP 3523
Score = 241 bits (615), Expect = 5e-63
Identities = 280/1089 (25%), Positives = 465/1089 (42%), Gaps = 171/1089 (15%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EVR++VRD NDN+P F S T E + G + + ATD D G NG
Sbjct: 120 EVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVIL-----DTATDSDIGSNGVDHRSY 174
Query: 192 QYNPDDPTSNDTFEIPLMLTG-----NIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ + +I L +G ++V + L+ E +Y ++++ D+ + +R
Sbjct: 175 RIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGE---PKRR 231
Query: 247 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 306
+ V V D +D P+F YQA +PE + ++ + +Q
Sbjct: 232 GYLQVNVTVQDINDNPPVF------------GSSHYQAGVPE-------DAVVGSSVLQV 272
Query: 307 IDQDRNIQPPSDRPGILYSIL-VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
D + +D I Y + GTP F M P T +++ EP++ + +++ L +
Sbjct: 273 AAADADEGTNAD---IRYRLQDEGTP------FQMDPETGLITVREPLDFEARRQYSLTV 323
Query: 366 KAEQDNGHP-LPAFAGLHIEILDENNQSP-----YFTMPSYQGYILESAPVGATI----- 414
+A D G P L A I++LD N+ P YF S + E+A VG +
Sbjct: 324 QA-MDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382
Query: 415 ----SDSLNLTSPLRIVALDK----DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
S + N ++I+ ++ +++ +K P L L + +
Sbjct: 383 TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSL-------------------IKVA 423
Query: 467 QPVDREEQQTYTFSITAFDGV---------QESEPVIVNIQVMDANDNTPTFPEISYDVY 517
+DRE +Y +++ D S + I V D ND+ P F + Y V
Sbjct: 424 SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483
Query: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVG 576
+ + PG V ++A D D G N + Y I+ G G F I++ +GL+T
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTG-------- 535
Query: 577 RTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 635
S+G LDRE + +L I+A D G S A + +
Sbjct: 536 ------------------SSG------GLDRELASQIVLNISARDQGVHPKVSYAQLVVT 571
Query: 636 VTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNF--- 688
+ DVND PVF ++SVVE NA G ++ATD D G NG V +SL
Sbjct: 572 LLDVNDEKPVFSQPEGYDVSVVE---NAPTGTELLMLRATDGDLGDNGTVRFSLQEAETD 628
Query: 689 NNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747
FR+ +G + T L+RE + +Y L+V+ATD P+ S + + +LDI+DNSPV
Sbjct: 629 RRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPV 688
Query: 748 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 805
F Y ++EN P G+ I + A D DLG N V Y I + + + F ++ +G +S
Sbjct: 689 FYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGD-RSRFQVNAQSGVIST 747
Query: 806 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 865
+LD E ++ + + A D P A VT+ V D D PPVFS+ Y +V
Sbjct: 748 RMALDRE----EKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVF 803
Query: 866 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 925
+ G + +V A D S + Y + +F + + +G++ T ++
Sbjct: 804 ENVALGYHVGSVSASTMD----LNSNISYLITTGD---QKGMFAINQVTGQLTTANVIDR 856
Query: 926 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVG 985
E + ++L VVA G + + + L+ P F Q V E G +
Sbjct: 857 EEQSFYQLKVVA-SGGTVTGDTMVNITVKDLNDNS-PHFLQ-AIESVNVVENWQAGHSIF 913
Query: 986 VISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1041
A +N ++YS+ N ++ F IN G I + GPLD + + +
Sbjct: 914 QAKAVDPDEGVNGMVLYSL-KQNPKNLFAINEKNGTISLLGPLD--------VHAGSYQI 964
Query: 1042 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1101
E++ +++ VP S++ + + + D N++ PVF + Y +SE + + +V+A+DKD
Sbjct: 965 EILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKD 1024
Query: 1102 TGNYSVMAYRLIIPPIKEGKEGFVVETY-TGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1160
+G +AY I EG G + G + + + V+A+D +
Sbjct: 1025 SGANGEIAY-----TIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEP 1079
Query: 1161 LSGKADVLV 1169
LS +V V
Sbjct: 1080 LSATVNVTV 1088
Score = 240 bits (613), Expect = 8e-63
Identities = 310/1290 (24%), Positives = 519/1290 (40%), Gaps = 188/1290 (14%)
Query: 57 VDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST-GRV-----LDRDPPMN 110
+D ++ K A PD S ++ + L++P+ + + G V LDR+ N
Sbjct: 2065 IDTVVFKAQATDPD-----SGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSN 2119
Query: 111 IHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGF 170
VV + + EV ++V D NDN+P F Y +NE T GT I F
Sbjct: 2120 YTLTVVATDKGQPSLSSST--EVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVF 2177
Query: 171 SGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFV 230
+ D D+G NGQ+ Y I + +N F I +TG I + K L+ E Y +
Sbjct: 2178 AADG-----DEGTNGQVRYGIV----NGNTNQEFRID-SVTGAITVAKPLDREKTPTYHL 2227
Query: 231 IIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELR 290
+QA DR RT T+T+++ +LD +D P+F + + +
Sbjct: 2228 TVQATDRGST---PRTDTSTVSIVLLDINDFVPVF-----------------ELSPYSVN 2267
Query: 291 TPEELNPIIVTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
PE L + T + A D DR L +L G ED F + + EL +
Sbjct: 2268 VPENLGTLPRTILQVVARDDDRGSNSK------LSYVLFGGNED--NAFTLSA-SGELGV 2318
Query: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
+ ++R+ ++F L+I A L +++ + D N+ P F +Y I E AP
Sbjct: 2319 TQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAP 2378
Query: 410 VGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPV 469
G T L + A D D +K+ + + + S FT+ + T + +
Sbjct: 2379 TG---------TDVLLVNASDADA--SKNAVIRIIGGN--SQFTINPS--TGQIITSALL 2423
Query: 470 DREEQQTYTFSITAFD-GVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 526
DRE + YT + D G E S V + V D NDN P F Y ++ + PG
Sbjct: 2424 DRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGS 2483
Query: 527 SVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAA 586
V +T DAD G N E+ Y + F I+ G I A + T+++ V+
Sbjct: 2484 FVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDG 2543
Query: 587 DNAPPAERSTGILTLGKALD------RESTDRY---------ILIITASD--GRPDGTST 629
+ P + +T + D +E T + + IT S G P
Sbjct: 2544 GSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYI 2603
Query: 630 ATVN----------------------------IVVTDVNDNA-PVFDPYLPRNLSVVEEE 660
A+ N +V + D P F Y +++V++
Sbjct: 2604 ASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVN 2663
Query: 661 ANA-------FVGQ------------VKATDPDAGINGQVHYSL--GNFNNLFRIT-SNG 698
NA F+ + V A D D+G NGQ+ Y + GN N F I + G
Sbjct: 2664 DNAPIFKEDPFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATG 2723
Query: 699 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 758
I + L+RE +Y L + ++D + +++ + I +LD +DN+P F + ++ V
Sbjct: 2724 EIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVP 2782
Query: 759 ENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 818
EN P G T+ ++ D D+G N R + F ++P TG++ + R L+ E
Sbjct: 2783 ENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFTINPSTGDIVISRPLNRE----DT 2838
Query: 819 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVK-GTPITTV 877
V A D T+ VT+ V D+ND P FS+ Y + P+ + G+ +T V
Sbjct: 2839 DRYRIRVSAHDSGWTVS---TDVTIFVTDINDNAPRFSRTSYY-LDCPELTEIGSKVTQV 2894
Query: 878 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIF------ 931
+A D D +V Y + + F + +G + + L + T F
Sbjct: 2895 FATDPDEGS--NGQVFYFIKS-----QSEYFRINATTGEIFNKQILKYQNVTGFSNVNIN 2947
Query: 932 --KLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVIS 988
+V + D G+P + S TV I ++ + P+F + +Y PV++ GT + ++
Sbjct: 2948 RHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYF-TPVTKNVKVGTKLIRVT 3006
Query: 989 AA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1043
A +N + Y I + N F ++N TG I V L + ++ + V A
Sbjct: 3007 AIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTA----- 3061
Query: 1044 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1103
+ P S+ A V+I + +EN H P F + + E + + V V A D+D
Sbjct: 3062 --KDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAA 3119
Query: 1104 NYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1161
++ Y I G E F + + TG++ A + + A D
Sbjct: 3120 MNGLIKY-----SISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVAR 3174
Query: 1162 SGKADVLVSVVNQLDMQVIV--SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIG 1219
+G V V+V++ D + + PT++E T ++ + G V+
Sbjct: 3175 TGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSG-TTVIHLNATDADSGTNAVIAYTV 3233
Query: 1220 ARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1249
D F ++ T T +D +T ++
Sbjct: 3234 QSSDSDLFVIDPNTGVITTQGFLDFETKQS 3263
Score = 237 bits (604), Expect = 9e-62
Identities = 267/1053 (25%), Positives = 448/1053 (42%), Gaps = 136/1053 (12%)
Query: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
+ D NDN P F SY ++ E PVG+T+ TD DDG N Q+ Y I
Sbjct: 1934 ILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVF-----NVTDADDGINSQLTYSI----- 1983
Query: 197 DPTSNDTF-EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
S D+ + + G + + K L+ E ++ Y +++Q +D Q R T+T +++ +
Sbjct: 1984 --ASGDSLGQFTVDKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIIL 2041
Query: 256 LDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQP 315
LD +D P FL LTY IPE TP + V QA D D
Sbjct: 2042 LDVNDNPPTFL----------SPKLTY---IPE-NTPID----TVVFKAQATDPD----- 2078
Query: 316 PSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP- 374
I Y++L F + E+ L ++R+ + L + A D G P
Sbjct: 2079 SGPNSYIEYTLL----NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVA-TDKGQPS 2133
Query: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
L + + + +LD N+ +P F Y+ I E+ G I +++ A D D E
Sbjct: 2134 LSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDI---------IQVFAADGD-E 2183
Query: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESE 491
T + +N T+ F + +T +T+ +P+DRE+ TY ++ A D ++
Sbjct: 2184 GTNGQVRYGIVNGNTNQEFRI--DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTD 2241
Query: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILV 550
V+I ++D ND P F Y V V ++ +++Q+ A D D GSN +++Y +
Sbjct: 2242 TSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFG 2301
Query: 551 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610
G + + +G + + ++ + L + A D+ PA
Sbjct: 2302 GNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPAL----------------- 2344
Query: 611 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 670
T T T+N++V DVNDN P F + V V A
Sbjct: 2345 ----------------TGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNA 2388
Query: 671 TDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATD-GAVHPR 728
+D DA N + G N+ F I S G I T+ L+RE +D Y LVVV +D G+ P
Sbjct: 2389 SDADASKNAVIRIIGG--NSQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPL 2446
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 786
S+ ++ + V D++DN P F + Y + G+ + + D D+G N + Y +
Sbjct: 2447 SSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL- 2505
Query: 787 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 846
S F + P G + L + + +TF V D TVTV
Sbjct: 2506 SGRNSEKFHIDPLRGAIMAAGPL------NGASEVTFSVHVKDGGSFPKTDSTTVTVRFV 2559
Query: 847 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS 906
+ D+P V +K M + + +TT+ L + Y + +
Sbjct: 2560 NKADFPKVRAKE-QTFMFPENQPVSSLVTTITGS-----SLRGEPMSYYIASGNL---GN 2610
Query: 907 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 966
F++++ +G+V L+ E + + + A D G P SS + I VL + +
Sbjct: 2611 TFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFK 2670
Query: 967 EEYRPPPVSELATKGTMVGVISAAAI------NQSIVYSIVSGNEEDTFGINNITGVIYV 1020
E+ P +SE+ + +++ +A+ N + Y IV+GN E++F IN+ TG I
Sbjct: 2671 ED---PFISEILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRS 2727
Query: 1021 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1080
PLD E + YVL +++ ++ PS+S + KV I I DEN++ P F + +
Sbjct: 2728 VRPLDREKVSHYVLTIKS-------SDKGSPSQSTSVKVMINILDENDNAPRF-SQIFSA 2779
Query: 1081 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFH 1140
V E++ + +V RV +D+D G ++ Y I + F + TG I + +
Sbjct: 2780 HVPENSPLGYTVTRVTTSDEDIGINAISRY-----SIMDASLPFTINPSTGDIVISRPLN 2834
Query: 1141 NMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1173
++ +V A D G +S + V+ +N
Sbjct: 2835 REDTDRYRIRVSAHDS-GWTVSTDVTIFVTDIN 2866
Score = 236 bits (602), Expect = 2e-61
Identities = 296/1125 (26%), Positives = 468/1125 (41%), Gaps = 161/1125 (14%)
Query: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYH--EVRIVVRDRNDNSPTFKHESYYATVNE 158
+ LDR+ + +++VVQV + + + +V I++ D NDN PTF + E
Sbjct: 2004 KALDRES-QSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPE 2061
Query: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
TP+ T +F ATD D GPN IEY + + S T + + LTG
Sbjct: 2062 NTPIDTVVFKA-----QATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE----- 2111
Query: 219 RLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCR 278
L+ E+ + Y + + A D+ Q +++T + V VLD +D P+F +
Sbjct: 2112 -LDREEVSNYTLTVVATDKGQ---PSLSSSTEVVVMVLDINDNNPIFAQAL--------- 2158
Query: 279 PLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFF 338
Y+ I E N + T IQ D + + Y I+ G F
Sbjct: 2159 ---YKVEINE-------NTLTGTDIIQVFAADGD---EGTNGQVRYGIVNGNTNQE---F 2202
Query: 339 HMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMP 398
+ T +++ +P++R+ + L ++A P + + I +LD N+ P F +
Sbjct: 2203 RIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELS 2262
Query: 399 SYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTG 458
Y + E+ T+ ++ L++VA D D LF + + FT++ +G
Sbjct: 2263 PYSVNVPENL---GTLPRTI-----LQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASG 2314
Query: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTPTFPEIS 513
L + Q +DRE ++ + ITA D P + +N+ V D NDN PTF +
Sbjct: 2315 ---ELGVTQSLDRETKERFVLMITATDS---GSPALTGTGTINVIVDDVNDNVPTFASKA 2368
Query: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM 573
Y + D G V+ + A DAD N I ++G F IN +TG I
Sbjct: 2369 YFTTIPEDAPTGTDVLLVNASDADASKNAVIR---IIGGNSQFTINPSTGQII------- 2418
Query: 574 IVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT- 631
T AL LDRE+ D Y L++ SD G P+ S++T
Sbjct: 2419 ----TSAL-----------------------LDRETKDNYTLVVVCSDAGSPEPLSSSTS 2451
Query: 632 VNIVVTDVNDNAPVFD--PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNF 688
V + VTDVNDN P F PY+ S +FV V TD D G N ++HYSL G
Sbjct: 2452 VLVTVTDVNDNPPRFQHHPYVTHIPS--PTLPGSFVFAVTVTDADIGPNSELHYSLSGRN 2509
Query: 689 NNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747
+ F I G+I A LN + + V DG P+ + T+ ++ ++ D P
Sbjct: 2510 SEKFHIDPLRGAIMAAGPLNGASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKAD-FPK 2566
Query: 748 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLR 807
T + EN P + + I + G +SY I S + + F + TG++S+ +
Sbjct: 2567 VRAKEQTFMFPENQPVSSLVTTITGSSL-RGEPMSYYIASGNLGNTFQIDQLTGQVSISQ 2625
Query: 808 SLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVA 865
LD+E +EA D G PP + + V D+ND P+F + + +
Sbjct: 2626 PLDFEKI----QKYVVWIEARD--GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEIL 2679
Query: 866 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 925
+ + I TV A D D P ++ Y + + + F + +G + + L+
Sbjct: 2680 -ENLSPRKILTVSAMDKDSG--PNGQLDYEIVNGNM---ENSFSINHATGEIRSVRPLDR 2733
Query: 926 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQ-EEYRPPPVSELATKGTM 983
E + + L + + D G P S+S V I +L + PRF+Q P S L T
Sbjct: 2734 EKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVPENSPLGYTVTR 2793
Query: 984 VGVISA-AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1041
V IN YSI+ + F IN TG I ++ PL+ E Y +RV A DS
Sbjct: 2794 VTTSDEDIGINAISRYSIMDASL--PFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSG 2851
Query: 1042 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1101
V + V I + D N++ P F + Y E + + V +V ATD D
Sbjct: 2852 WTV-----------STDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPD 2900
Query: 1102 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML--------FHNMRRSYFKFQVIA 1153
G+ + Y IK E F + TG I + F N+ + F V +
Sbjct: 2901 EGSNGQVFYF-----IKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTS 2955
Query: 1154 TDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTE 1198
+D L + V +++V+ D N P L K +T+
Sbjct: 2956 SDRGKPSLISETTVTINIVDSND------NAPQFLKSKYFTPVTK 2994
Score = 230 bits (586), Expect = 1e-59
Identities = 263/1013 (25%), Positives = 413/1013 (40%), Gaps = 131/1013 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHE-----SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
E I + D NDN P K S YA+V+E VGT +
Sbjct: 338 EALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVV-------------------- 377
Query: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ + D P +N + + L GN ++ ++E ++ + A L+ R
Sbjct: 378 -ALLTVTDADSPAANGNISVQI-LGGN----EQRHFEVQSSKVPNLSLIKVASALDRERI 431
Query: 247 TTTTLTVDVLDGDDLGP--------MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPI 298
+ LTV V D P V+ N + P + + + EE P
Sbjct: 432 PSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPG 491
Query: 299 IVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHM--HPRTAELSLLEPVNRD 356
I A D D + + YSI+ G + FH+ H ++R+
Sbjct: 492 SYVSGISATDGDSGLNA-----NLRYSIVSGNGLGW---FHISEHSGLVTTGSSGGLDRE 543
Query: 357 FHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS-YQGYILESAPVGATIS 415
+ L I A HP ++A L + +LD N++ P F+ P Y ++E+AP G
Sbjct: 544 LASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTG---- 599
Query: 416 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
T L + A D D+ D L + T + ++ L+ + +DREEQ
Sbjct: 600 -----TELLMLRATDGDLGDNGTVRFSLQEAE-TDRRSFRLDPVSGRLSTISSLDREEQA 653
Query: 476 TYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Y+ + A D +S +N+ ++D NDN+P F + Y ++ + G + ++A
Sbjct: 654 FYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSA 713
Query: 534 VDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
D D G+NG + Y I G + F +N +G+I+
Sbjct: 714 TDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTR------------------------- 748
Query: 594 RSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPR 652
ALDRE Y L I A+D G + A V I V D DN PVF +
Sbjct: 749 ---------MALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFS-QVAY 798
Query: 653 NLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREV 710
+ V E A + VG V A+ D N + G+ +F I G + TA ++RE
Sbjct: 799 SFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREE 858
Query: 711 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 770
+ +Y+L VVA+ G V + I V D++DNSP F + +V V EN AG +I Q
Sbjct: 859 QSFYQLKVVASGGTV---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQA 915
Query: 771 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 828
+A D D G N V Y ++ K+ FA++ G +SLL LD A S + A
Sbjct: 916 KAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLDVHA-----GSYQIEILAS 969
Query: 829 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 888
D+ +TV V D+ND PVF + Y+ ++ + V A D D
Sbjct: 970 DMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGA-- 1027
Query: 889 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 948
+ Y + + IF G++ + L+ E + L+VVA D +S++
Sbjct: 1028 NGEIAYTIAEGNTGDAFGIF----PDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSAT 1083
Query: 949 ATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSG 1003
V +++ + P F Y E G+ VG +SA N + YS
Sbjct: 1084 VNVTVILEDVNDNRPLFNSTNY-TFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM- 1141
Query: 1004 NEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVVLANLRVPSK-SNTAKVY 1060
+ F ++ I+G I D R S + R S V+ + +P + A V+
Sbjct: 1142 -VQPDFELHAISGEITNTHQFD---RESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVH 1197
Query: 1061 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1113
+ ++D N++ P F K FY +SE A T VLRV A+D D GN ++ Y +I
Sbjct: 1198 VYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSII 1250
Score = 209 bits (532), Expect = 2e-53
Identities = 216/780 (27%), Positives = 340/780 (43%), Gaps = 87/780 (11%)
Query: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAND 504
L++ ++F + + Y T +DRE + ++ + P V + V D ND
Sbjct: 74 LSESHALFAINSSTGALYTT--STIDRESLPSDVINLVVLSSAP-TYPTEVRVLVRDLND 130
Query: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--EITYEILVGAQ-GDFIINKT 561
N P FP+ S V D G VI TA D+D GSNG +Y I+ G + G F ++ T
Sbjct: 131 NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD 621
P E + L LDRE T +Y L++ D
Sbjct: 191 LN--------------------------PSGEGAFLHLVSKGGLDREVTPQYQLLVEVED 224
Query: 622 -GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGIN 678
G P VN+ V D+NDN PVF + V E+A + V QV A D D G N
Sbjct: 225 KGEPKRRGYLQVNVTVQDINDNPPVFGS--SHYQAGVPEDAVVGSSVLQVAAADADEGTN 282
Query: 679 GQVHYSLGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 737
+ Y L + F++ G I L+ E R Y L V A D V I+
Sbjct: 283 ADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQ 342
Query: 738 VLDIDDNSPV-----FTNSTYTVLVEENLPAGTTILQIEAKDVDLGA---NVSYRIRSP- 788
+LD++DN PV F ++ V+EN GT + + D D A N+S +I
Sbjct: 343 LLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGN 402
Query: 789 EVKHFFALHPFTGELSLLR---SLDYEAFPDQEASITFLVEAFDIYGTMPPG-------- 837
E +HF LSL++ +LD E P S V D YG PPG
Sbjct: 403 EQRHFEVQSSKVPNLSLIKVASALDRERIP----SYNLTVSVSDNYGA-PPGAAVQARSS 457
Query: 838 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 897
+A++ + V D+ND+PPVFS+++Y+ ++ +A G+ ++ + A D D GL A+ +RY +
Sbjct: 458 VASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDS-GLNAN-LRYSIV 515
Query: 898 DVQFPYPASIFEVEEDSGRVITRVN--LNEEPTTIFKLVVVAFDDG-EPVMSSSATVKIL 954
F + E SG V T + L+ E + L + A D G P +S + V L
Sbjct: 516 SGN---GLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTL 572
Query: 955 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGN-EEDTF 1009
+ E P F+Q E V E A GT + ++ A N ++ +S+ + +F
Sbjct: 573 LDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSF 632
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
++ ++G + LD E + Y SL V+ +L P +S+ A++ + + D N++
Sbjct: 633 RLDPVSGRLSTISSLDREEQAFY-------SLLVLATDLGSPPQSSMARINVSLLDINDN 685
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PVF Y + E+ + + V ATD D G + Y + + F V
Sbjct: 686 SPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAGD----RSRFQVNAQ 741
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
+G+I T M ++ ++ Q++ATD +A V ++V++ D + S V + V
Sbjct: 742 SGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801
Score = 204 bits (520), Expect = 5e-52
Identities = 253/967 (26%), Positives = 403/967 (41%), Gaps = 141/967 (14%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I + D NDN+P F + + A V E +P+G T+ + D D G N Y I
Sbjct: 2758 KVMINILDENDNAPRFS-QIFSAHVPENSPLGYTVTRVTTSDE-----DIGINAISRYSI 2811
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
T N + TG+IV+ + LN ED RY + + A+D T +T +
Sbjct: 2812 MDASLPFTINPS-------TGDIVISRPLNREDTDRYRIRVSAHDSGW------TVSTDV 2858
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL-RTPEELNPIIVTPPIQAIDQD 310
T+ V D +D P F +Y PEL ++ + T P D+
Sbjct: 2859 TIFVTDINDNAPRF------------SRTSYYLDCPELTEIGSKVTQVFATDP----DEG 2902
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAEL---SLLEPVNRDFHQKFDL---- 363
N Q + Y I + +F ++ T E+ +L+ N ++
Sbjct: 2903 SNGQ-------VFYFI-----KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHS 2950
Query: 364 VIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
I D G P L + + I I+D N+ +P F Y + ++ VG T
Sbjct: 2951 FIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVG---------TK 3001
Query: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
+R+ A+D D + + E+ F+++ + T ++++ + + Q + ++T
Sbjct: 3002 LIRVTAID-DKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVT 3060
Query: 483 AFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
A D S V+I V + N +TP F + + G V ++A D D
Sbjct: 3061 AKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAM 3120
Query: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
NG I Y I G +G F IN STGIL
Sbjct: 3121 NGLIKYSISSGNEEGIFAINS----------------------------------STGIL 3146
Query: 600 TLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNL 654
TL KALD E ++ + I+A DG G + TVN++ DVNDN+PVF D Y P L
Sbjct: 3147 TLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI--DVNDNSPVFLSDDYFPTVL 3204
Query: 655 SVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-GSIYTAVKLNREVRD 712
+ V + ATD D+G N + Y++ + ++LF I N G I T L+ E +
Sbjct: 3205 E--NAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQ 3262
Query: 713 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 772
Y L V A + R S T+ I++ ++ P F + Y + E P GT + ++ A
Sbjct: 3263 SYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFA 3322
Query: 773 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 830
D DLG + V Y I K F ++ TG++ + LD E ++ S+ L + F
Sbjct: 3323 SDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK--EERVSLKVLAKNFGS 3380
Query: 831 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA- 889
TV V V D ND PP+F+ IY ++ GT +T V A D+D +P+
Sbjct: 3381 IRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSD--SIPSW 3437
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
SR Y + F + +G++ L+ E I+ L V+A D G P + SA
Sbjct: 3438 SRFSYFIGSGN---ENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSA 3494
Query: 950 TVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQS-IVYSIVSG 1003
++ + + + P T E V E GT+V + + NQ Y ++S
Sbjct: 3495 SLLVTLEDINDNGPMLTVSEGE---VMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLST 3551
Query: 1004 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1063
++ + GV+ +D E + L VV + VP S+T V+I +
Sbjct: 3552 GPATSYFSLSTAGVLSTTREIDREQIADFYL-------SVVTKDSGVPQMSSTGTVHITV 3604
Query: 1064 QDENNHP 1070
D+N++P
Sbjct: 3605 IDQNDNP 3611
Score = 197 bits (502), Expect = 6e-50
Identities = 237/830 (28%), Positives = 356/830 (42%), Gaps = 106/830 (12%)
Query: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD-KDIEDTKDP 439
+ + + D N+ +P F PS E + G + S + +D + +
Sbjct: 121 VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180
Query: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEP----- 492
E F D T+ +G +L L+ +DRE Y + D + EP
Sbjct: 181 EAGRFRLD----ITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED---KGEPKRRGY 233
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
+ VN+ V D NDN P F Y V D G SV+Q+ A DADEG+N +I Y L
Sbjct: 234 LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDE 292
Query: 553 QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDR 612
F ++ TGLIT+ ++ R Y+LTVQA D
Sbjct: 293 GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDR------------------------ 328
Query: 613 YILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKA- 670
G P T A I + DVNDN PV Y P + NA VG V A
Sbjct: 329 ---------GVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVAL 379
Query: 671 ---TDPDA-GINGQVHYSL--GNFNNLFRITSN-----GSIYTAVKLNREVRDYYELVVV 719
TD D+ NG + + GN F + S+ I A L+RE Y L V
Sbjct: 380 LTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVS 439
Query: 720 ATD-------GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 772
+D AV R S +L I V DI+D+ PVF+ Y V + E P G+ + I A
Sbjct: 440 VSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISA 499
Query: 773 KDVD--LGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPDQEASITFLVEAF 828
D D L AN+ Y I S +F + +G ++ S LD E + I + A
Sbjct: 500 TDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDREL----ASQIVLNISAR 555
Query: 829 DIYGTMPP-GIATVTVIVKDMNDYPPVFSK-RIYKGMVAPDAVKGTPITTVYAEDADPPG 886
D G P A + V + D+ND PVFS+ Y V +A GT + + A D D
Sbjct: 556 D-QGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLG- 613
Query: 887 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 946
VR+ + + + + F ++ SGR+ T +L+ E + L+V+A D G P S
Sbjct: 614 -DNGTVRFSLQEAETDRRS--FRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQS 670
Query: 947 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIV 1001
S A + + +L + P F +Y + E G+ + +SA N ++ YSI
Sbjct: 671 SMARINVSLLDINDNSPVFYPVQYF-AHIKENEPGGSYITTVSATDPDLGTNGTVKYSIS 729
Query: 1002 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1061
+G + F +N +GVI LD E +T+Y L++ A NL+ P N A V I
Sbjct: 730 AG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD----GGNLQSP---NQAIVTI 781
Query: 1062 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK 1121
+ D ++PPVF + Y V E+ + V V A+ D S ++Y LI ++G
Sbjct: 782 TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN--SNISY-LITTGDQKGM 838
Query: 1122 EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1171
F + TG + TA + +S+++ +V+A+ G ++G V ++V
Sbjct: 839 --FAINQVTGQLTTANVIDREEQSFYQLKVVAS---GGTVTGDTMVNITV 883
Score = 171 bits (433), Expect = 6e-42
Identities = 189/646 (29%), Positives = 296/646 (45%), Gaps = 61/646 (9%)
Query: 566 TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPD 625
T+ ++ G TY L+ A A STG L +DRES ++ + P
Sbjct: 59 TLVGTIQTRPGFTYRLSESHALFA--INSSTGALYTTSTIDRESLPSDVINLVVLSSAP- 115
Query: 626 GTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQV---KATDPDAGINGQV 681
T V ++V D+NDNAPVF DP ++ V +E ++ QV ATD D G NG
Sbjct: 116 -TYPTEVRVLVRDLNDNAPVFPDP----SIVVTFKEDSSSGRQVILDTATDSDIGSNGVD 170
Query: 682 HYSL----GNFNNLFR--ITSNGS-------IYTAVKLNREVRDYYELVVVATDGAVHPR 728
H S GN FR IT N S + + L+REV Y+L+V D R
Sbjct: 171 HRSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKR 230
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 788
L + + V DI+DN PVF +S Y V E+ G+++LQ+ A D D G N R R
Sbjct: 231 RGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQ 290
Query: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 848
+ F + P TG +++ LD+EA ++ S+T V+A D G A + + D+
Sbjct: 291 DEGTPFQMDPETGLITVREPLDFEA--RRQYSLT--VQAMDRGVPSLTGRAEALIQLLDV 346
Query: 849 NDYPPVFSKRIYK-----GMVAPDAVKGTPITTVYAEDADPPGLPAS-RVRYRVDDVQFP 902
ND PV R + V +A GT + + DAD P + V+ + Q
Sbjct: 347 NDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRH 406
Query: 903 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEP---VMSSSATVKILVLHP 958
+ +V S + L+ E + L V D+ G P + + ++V LV+
Sbjct: 407 FEVQSSKVPNLS-LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFV 465
Query: 959 GEI----PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFG 1010
+I P F+Q+ YR +SE A G+ V ISA + +N ++ YSIVSGN F
Sbjct: 466 NDINDHPPVFSQQVYR-VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFH 524
Query: 1011 INNITGVIYV--NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1068
I+ +G++ +G LD E + VL + A + V K + A++ + + D N+
Sbjct: 525 ISEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQGVHPKVSYAQLVVTLLDVND 577
Query: 1069 HPPVF-QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1127
PVF Q + Y V E+A T +L ++ATD D G+ + R + + + F ++
Sbjct: 578 EKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV--RFSLQEAETDRRSFRLD 635
Query: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1173
+G + T ++++ V+ATD S A + VS+++
Sbjct: 636 PVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Score = 68.9 bits (167), Expect = 4e-11
Identities = 93/413 (22%), Positives = 174/413 (42%), Gaps = 62/413 (15%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I ++ N+ P F + YY ++E P GT + G+ A+D D G +G++ Y+I
Sbjct: 3284 VNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIV-----GEVFASDRDLGTDGEVHYLIF 3338
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAND----RAQNLNERRTTT 248
N + F+I TG I + L+ E + R + + A + R +++E
Sbjct: 3339 GN----SRKKGFQINKK-TGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDE----- 3388
Query: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
T+ V VLD +D P+F + + P+ + A D
Sbjct: 3389 VTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTF-----------------VSAFD 3430
Query: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
D P R +S +G+ + F ++P+T ++++ ++R+ ++L + A
Sbjct: 3431 SDSI--PSWSR----FSYFIGSGNENGAF-SINPQTGQITVTAELDRETLPIYNLSVLAV 3483
Query: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
A L + + D N+ P T+ +G ++E+ G + + + +
Sbjct: 3484 DSGTPSATGSASLLVTLEDINDNGPMLTVS--EGEVMENKRPGTLV---------MTLQS 3532
Query: 429 LDKDIEDTKDPELHLFLND--YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD- 485
D D+ + P + L+ TS F+++ G+ L+ + +DRE+ + S+ D
Sbjct: 3533 TDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGV---LSTTREIDREQIADFYLSVVTKDS 3589
Query: 486 GV-QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
GV Q S V+I V+D NDN + V Y ++ PG + + D D
Sbjct: 3590 GVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPD 3642
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 285 bits (729), Expect = 3e-76
Identities = 306/1078 (28%), Positives = 472/1078 (43%), Gaps = 138/1078 (12%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
Y +V+I + + NDN P F Y ++ E VGT++ T ATD D G G++ Y
Sbjct: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-----ATDNDAGTFGEVSY 497
Query: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
DDP D F + TG I+L RL+YE R+ + I A D TT
Sbjct: 498 FFS---DDP---DRFSLDKD-TGLIMLIARLDYELIQRFTLTIIARDGGGE-----ETTG 545
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
+ ++VLD +D P F V R+ P Q ++A D+
Sbjct: 546 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV-----------------RLRATDE 588
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD----LVI 365
D PP+++ I YSI+ + ++ +S+ P+ D+ Q + L +
Sbjct: 589 D---SPPNNQ--ITYSIVSASAFGSYFDISLYEGYGVISVSRPL--DYEQISNGLIYLTV 641
Query: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
A PL + + IE+ DEN+ P F+ P+Y ++E+ GAT+ L
Sbjct: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATV---------LF 692
Query: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
+ A D D E ++ + ++ F + + +T +DRE + Y + A D
Sbjct: 693 LNATDLDRSREYGQESIIYSLEGSTQFRINAR--SGEITTTSLLDRETKSEYILIVRAVD 750
Query: 486 GV----QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
G Q++ VNI ++D NDN PT+ + Y + + P V + AVD D G N
Sbjct: 751 GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810
Query: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTL 601
G + Y I + + +N TTG I T+A+
Sbjct: 811 GTLVYSIQPPNKF-YSLNSTTGKIRT----------THAM-------------------- 839
Query: 602 GKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLPR 652
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 840 ---LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LPF 895
Query: 653 NLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 708
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+R
Sbjct: 896 VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDR 955
Query: 709 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 768
E Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P ++
Sbjct: 956 ERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
Query: 769 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826
+ D D+G N +SY I V F++ + + LD E A+ ++E
Sbjct: 1016 WLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLILE 1071
Query: 827 AFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884
A D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 1072 AIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADE 1131
Query: 885 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEP 943
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 1132 GEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
Query: 944 VMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVY 998
M SS V + V E P FTQ++Y + E A GT V V+ A + + Y
Sbjct: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
Query: 999 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1058
I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1247 RILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFCS 1298
Query: 1059 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1118
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTST 1356
Query: 1119 EGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1357 QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
Score = 265 bits (677), Expect = 3e-70
Identities = 327/1308 (25%), Positives = 553/1308 (42%), Gaps = 185/1308 (14%)
Query: 91 KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
++ F+N+T R LDR+ P +I V+ N ++ Y + I + D NDN
Sbjct: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
Query: 144 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT 203
P F +Y A V E +P GT + T +G A D D + Y + +
Sbjct: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL-----GAQSGL 2009
Query: 204 FEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
F+I TG + +R + + + I++ A+++ +T L + +LD +D P
Sbjct: 2010 FDINSS-TGVVTVRSGVIIDREAFSPPILELLLLAEDIG-LLNSTAHLLITILDDNDNRP 2067
Query: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
F P L + + P P + A D+D + ++
Sbjct: 2068 TFSPATLTVHLLENCP-----------------PGFSVLQVTATDEDSGLNGE-----LV 2105
Query: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEP-VNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 382
Y I G + F +H T + + ++R+ + + L + A PL A +
Sbjct: 2106 YRIEAGAQDR----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
Query: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED------- 435
I I D N+ P F P +LESA G I++ I A+D D+
Sbjct: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIV 2212
Query: 436 ---TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP 492
KD L N + TG + + P++RE TY +++ D +
Sbjct: 2213 GIVAKDDTDRLVPNQEDAFAVNINTGS---VMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
Query: 493 VIVNI-------QVMDANDNTPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNG 542
V++ V+D NDNTP F Y + PG ++I + AVD D+G NG
Sbjct: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
Query: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLG 602
+TY +L + PG VQ D+ S G +
Sbjct: 2330 LVTYTLLD---------------LVPPGY-----------VQLEDS------SAGKVIAN 2357
Query: 603 KALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 661
+ +D E + ASD G P + V + + D+NDN P+FD + +
Sbjct: 2358 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV 2417
Query: 662 NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVA 720
+ V ATD D+G + YSLG+ + F I + G IY L+RE +D+Y L +A
Sbjct: 2418 GTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALA 2477
Query: 721 TDG----AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776
D A + R +++ + I+VLD++D P F+ ++ V EN PAGT+++ + A D D
Sbjct: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
Query: 777 LGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD-YEAFPDQEASITFLVEAFDIYGT 833
G N ++Y + P V+ F + +G ++ R L YE F + V A D G
Sbjct: 2538 EGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQRPLQSYEKF-------SLTVVATD--GG 2587
Query: 834 MPP--GIATVTVIVKDMNDYPPVFSKRIYKGM--VAPDAVKGTPITTVYAEDADPPGLPA 889
PP G + V V D+ND PVF + + + + + + VYA D D GL
Sbjct: 2588 EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNG 2646
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
+ VRY F ++ SG + T L+ E ++ L++VA D G+PV +
Sbjct: 2647 A-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETM 2705
Query: 950 TVKILVLHP--GEIPRFTQE-----EYRPPPVSELATKGTMVGVISAAAI-----NQSIV 997
+ L P F + +Y+ V E + +GT+VG ++ A N +
Sbjct: 2706 QPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVY 2765
Query: 998 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA------NLRVP 1051
Y I +GNEE F + G + V LD E + V+A S L +
Sbjct: 2766 YFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
Query: 1052 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN-----YS 1106
+ +V + ++D N+ PP F K Y GV+ DA++ + +++V A D D GN YS
Sbjct: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
Query: 1107 VMA---YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1163
++A +R + ++ + F + + G+++T LF YF ++A D L+G
Sbjct: 2885 ILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARD-----LAG 2939
Query: 1164 KADVLVSVVNQL--DMQV-IVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGA 1220
D + + L D +V IV N P V E+ +L I GA +V +
Sbjct: 2940 HNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLL-----SNITGA--IVNTDNV 2992
Query: 1221 RRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRI 1280
+ H D ++ + +L ++ ++ TNR +D + + + +D + F+ Y +
Sbjct: 2993 QFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNY-----NV 3047
Query: 1281 LEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSY 1328
L+++ +V + + + + A++ LA ++ L A+L VL+++
Sbjct: 3048 LDVQPAISV----RLPDDMSALQMAIIVLAILLFLA---AMLFVLMNW 3088
Score = 259 bits (662), Expect = 2e-68
Identities = 298/1093 (27%), Positives = 472/1093 (43%), Gaps = 137/1093 (12%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
V + + D NDN+P F+ Y ++E + T++ T A D+D+GPNG + Y I
Sbjct: 1620 VYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-----IQALDLDEGPNGTVTYAI 1674
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTT 250
+TF I + G I K L+YE RY +I+ A D+ L+ R T+TTT
Sbjct: 1675 VAG----NIVNTFRIDRHM-GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
+ V+V D +D P F P Y+ P T + P + T + D
Sbjct: 1730 VLVNVNDINDNVPTF-------------PRDYEG--PFEVTEGQPGPRVWT----FLAHD 1770
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV--NRDFHQKFDLVIKAE 368
R+ P + YSI+ G P F + P L + + V +R+ ++L I A
Sbjct: 1771 RDSGPNGQ---VEYSIMDGDPLGE---FVISPVEGVLRVRKDVELDRETIAFYNLTICAR 1824
Query: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS-PLRIV 427
PL + + I +LD N+ P +L + P+ TIS++ ++S ++
Sbjct: 1825 DRGMPPLSSTMLVGIRVLDINDNDP----------VLLNLPMNITISENSPVSSFVAHVL 1874
Query: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 486
A D D ++ + F + T T +T+ +P+DRE Y +I+ D
Sbjct: 1875 ASDADSGCNARLTFNITAGNRERAFFINAT--TGIVTVNRPLDRERIPEYKLTISVKDNP 1932
Query: 487 ----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT----AVDADE 538
+ + ++ I + D NDN P F + +Y V + G + L A+DAD+
Sbjct: 1933 ENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ 1992
Query: 539 GSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGI 598
+TY++L G F IN +TG++T+ GV
Sbjct: 1993 DIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGV--------------------------- 2025
Query: 599 LTLGKALDRESTDRYIL-IITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
+DRE+ IL ++ ++ STA + I + D NDN P F P + ++
Sbjct: 2026 -----IIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSP-ATLTVHLL 2079
Query: 658 EEEANAF-VGQVKATDPDAGINGQVHYSL---GNFNNLFRITSNGSIYTAVKLNREVRDY 713
E F V QV ATD D+G+NG++ Y + L + + ++RE ++
Sbjct: 2080 ENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQES 2139
Query: 714 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 773
Y L VVATD P T + I + DI+D+ P F N TV V E+ GT I I A
Sbjct: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
Query: 774 DVDLGANVSYRIRS-----------PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 822
D DL + Y I P + FA++ TG + + ++ E E +++
Sbjct: 2200 DHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
Query: 823 FLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSK---RIYKGMVAPDAVKGTPITTVY 878
+ A D+ ++ A +TV V D+ND P F Y + A GT + V
Sbjct: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
Query: 879 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS-GRVITRVNLNEEPTTIFKLVVVA 937
A D D GL V Y + D+ P ++E+ S G+VI ++ E V A
Sbjct: 2320 AVDPD-KGL-NGLVTYTLLDL---VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRA 2374
Query: 938 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS- 995
D+G P ++ V + ++ + P F Q Y+ V E GT++ ++A +
Sbjct: 2375 SDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQ-EAVFEDVPVGTIILTVTATDADSGN 2433
Query: 996 ---IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1052
I YS+ G+ E F IN TG IYV LD E + Y+L A +A+ R
Sbjct: 2434 FALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR--- 2488
Query: 1053 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112
+ N+ +V I++ D N+ P F K + V E+ TSV+ + ATD+D G + Y L
Sbjct: 2489 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL 2548
Query: 1113 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1172
P G E F V+ +GL+ T + + F V+ATD L G +LV V+
Sbjct: 2549 EGP----GVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVI 2602
Query: 1173 NQLDMQVIVSNVP 1185
+ D + + P
Sbjct: 2603 DVNDNRPVFVRPP 2615
Score = 249 bits (635), Expect = 2e-65
Identities = 294/1095 (26%), Positives = 457/1095 (41%), Gaps = 148/1095 (13%)
Query: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
Query: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Query: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
Query: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
Query: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
Query: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 477
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
Query: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
Query: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERST 596
D G+ GE++Y F ++K TGLI M++ R
Sbjct: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLI-------MLIAR------------------- 520
Query: 597 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 656
LD E R+ L I A DG + T T V I V DVNDN P F
Sbjct: 521 --------LDYELIQRFTLTIIARDGGGEET-TGRVRINVLDVNDNVPTFQKDAYVGALR 571
Query: 657 VEEEANAFVGQVKATDPDAGINGQVHYSL---GNFNNLFRITSNGSIYTAVKLNREVRDY 713
E + + +++ATD D+ N Q+ YS+ F + F I+ Y + ++R + DY
Sbjct: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEG-YGVISVSRPL-DY 629
Query: 714 YE-------LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766
+ L V+A D P +ST+ + I+V D +DN P F+ Y V V EN+ AG T
Sbjct: 630 EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
Query: 767 ILQIEAKDVDLGANVSYR--IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824
+L + A D+D I S E F ++ +GE++ LD E ++ +
Sbjct: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRET----KSEYILI 745
Query: 825 VEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 882
V A D + GIATV + + D+ND P + Y + + +TTV A D
Sbjct: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
Query: 883 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT------RVNLNEEPTTIFKLVVV 936
D G + V Y + P + + +G++ T R N + + + +VV
Sbjct: 806 D-LGENGTLV-YSIQP-----PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVV 858
Query: 937 AFDD-GEPVM--SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA---- 989
+ D G P + +SSATV + +L + Q V E G + + A
Sbjct: 859 SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLD 918
Query: 990 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1049
+N + Y + G F IN+ +GV+ LD E Y LR VV ++
Sbjct: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR-------VVASDAG 971
Query: 1050 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1109
P+KS+T+ + I + D N+ P F Y VSED V+ + TD D G + ++
Sbjct: 972 TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
Query: 1110 YRL----IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1165
Y + + G VV T GL + + + + I GK +G A
Sbjct: 1032 YFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYML-----ILEAIDNGPVGKRHTGTA 1086
Query: 1166 DVLVSVVNQLDMQVI 1180
V V+V++ D + I
Sbjct: 1087 TVFVTVLDVNDNRPI 1101
Score = 244 bits (623), Expect = 6e-64
Identities = 315/1195 (26%), Positives = 502/1195 (42%), Gaps = 179/1195 (14%)
Query: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
Query: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
Query: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Query: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
Query: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
+F +PL Y ++ E N + T + + D + + +
Sbjct: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
Query: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
Query: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
Query: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
Query: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYIL 615
F IN +G IT LDRE+ YIL
Sbjct: 719 FRINARSGEITTT----------------------------------SLLDRETKSEYIL 744
Query: 616 IITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKAT 671
I+ A DG T ATVNI + D+NDN P + P +++VE ++ V V A
Sbjct: 745 IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD-APYYINLVEMTPPDSDVTTVVAV 803
Query: 672 DPDAGINGQVHYSLGNFNNLFRITSN-GSIYTA-VKLNREVRDYYE------LVVVATDG 723
DPD G NG + YS+ N + + S G I T L+RE D +E +VV TD
Sbjct: 804 DPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
Query: 724 AVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN- 780
P +T T+ + +LD++DN P F N + V E +PAG +I Q+ A D+D G N
Sbjct: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
Query: 781 -VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 839
VSYR+ + F ++ +G + LD E + + + A D +
Sbjct: 924 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV----ASDAGTPTKSSTS 979
Query: 840 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 899
T+T+ V D+ND P F +Y V+ D + + + D D GL A + Y +
Sbjct: 980 TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV-GLNAE-LSYFITGG 1037
Query: 900 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV---MSSSATVKILVL 956
F V V T V L+ E T + L++ A D+G PV + +ATV + VL
Sbjct: 1038 NVD---GKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVL 1093
Query: 957 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGI 1011
+ P F Q Y V E +G + + A ++ + Y I+ GN + F I
Sbjct: 1094 DVNDNRPIFLQSSYEAS-VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
Query: 1012 NNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070
+ G++ PLD E +S+VL V+A + ++ P +S+ +V + ++D N+
Sbjct: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG------PMRSSV-RVIVYVEDINDEA 1205
Query: 1071 PVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVET 1128
PVF ++ Y G+ E A + TSV+ V+ATD+D+G+ ++ YR++ G EG F ++
Sbjct: 1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-----SGAEGKFEIDE 1260
Query: 1129 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
TGLI T ++ + V ATD G V ++++N+LD V SN
Sbjct: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
Score = 233 bits (593), Expect = 2e-60
Identities = 321/1242 (25%), Positives = 504/1242 (40%), Gaps = 217/1242 (17%)
Query: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
+Y+AAI E L IV +ID I Y T
Sbjct: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
Query: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
S I E PVG ++ + A D D L + F +
Sbjct: 1421 TSDSAVSIPEDCPVGQRVA---------TVKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
Query: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPE-I 512
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAP-- 569
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Query: 570 ------------------GVEMIVGRT--YALTVQAADNAP--------------PAERS 595
G + T Y V DNAP P +
Sbjct: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
Query: 596 TGILTL-------------------------------------GKALDRE-STDRYILII 617
T ++T+ K LD E S RY LI+
Sbjct: 1652 TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIV 1711
Query: 618 TASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDP 673
TA+D P TST TV + V D+NDN P F V E + V A D
Sbjct: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDR 1771
Query: 674 DAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAVHPR 728
D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D + P
Sbjct: 1772 DSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPL 1831
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 786
ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++ I
Sbjct: 1832 SSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT 1891
Query: 787 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA-----TV 841
+ + F ++ TG +++ R LD E P+ + +I+ + P IA +
Sbjct: 1892 AGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDYDLL 1945
Query: 842 TVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRYRVD 897
+ + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y++
Sbjct: 1946 LIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTYQLL 2003
Query: 898 DVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKI 953
Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A + I
Sbjct: 2004 GAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLI 2057
Query: 954 LVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNE 1005
+L + P F+ E PP S L T + +N +VY I +G
Sbjct: 2058 TILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEAG-A 2112
Query: 1006 EDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1064
+D F I+ +TGVI V N +D E + SY L V A V S TA V I I
Sbjct: 2113 QDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTILID 2165
Query: 1065 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG---- 1120
D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 2166 DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDTDRL 2223
Query: 1121 ----KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----VSVV 1172
++ F V TG + M +S +++AT + + A L VSV
Sbjct: 2224 VPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
Query: 1173 NQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1214
N + V V +V + K +T ++R ++ PG ++
Sbjct: 2276 N-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
Score = 224 bits (572), Expect = 5e-58
Identities = 281/1075 (26%), Positives = 455/1075 (42%), Gaps = 161/1075 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
V + V D NDN PTF + Y E+T G ++T + D D GPNGQ+EY
Sbjct: 1730 VLVNVNDINDNVPTFPRD--YEGPFEVTEGQPGPRVWTFLAHDR-----DSGPNGQVEYS 1782
Query: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF--VIIQANDRAQNLNERRTTT 248
I DP + G + +RK + + +T F + I A DR ++T
Sbjct: 1783 IM--DGDPLGEFVIS---PVEGVLRVRKDVELDRETIAFYNLTICARDRGM---PPLSST 1834
Query: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII-VTPPIQAI 307
+ + VLD +D P+ L +P T E +P+ + A
Sbjct: 1835 MLVGIRVLDINDNDPVLLN------------------LPMNITISENSPVSSFVAHVLAS 1876
Query: 308 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
D D + ++I G E R F ++ T +++ P++R+ ++ L I
Sbjct: 1877 DADSGCNAR-----LTFNITAGNRE---RAFFINATTGIVTVNRPLDRERIPEYKLTISV 1928
Query: 368 EQDNGHPLPA---FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
+ + +P A + L I + DEN+ P FT +YQ ++E++P G ++ L P+
Sbjct: 1929 KDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV---LNGPI 1985
Query: 425 RIVALDKDIEDTKDPEL-----HLF-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
+ D+DI +L LF +N T V TV ++G+ +DRE
Sbjct: 1986 LALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV-RSGVI--------IDRE-----A 2031
Query: 479 FSITAFDGVQESEPV-IVN------IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 531
FS + + +E + ++N I ++D NDN PTF + V++ + PG SV+Q+
Sbjct: 2032 FSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
Query: 532 TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAP 590
TA D D G NGE+ Y I GAQ F+I+ TG+I + ++ +Y LTV A D
Sbjct: 2092 TATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGT 2151
Query: 591 PAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 650
T I+T ILI +D RP+ + V+ +
Sbjct: 2152 VPLSGTAIVT-------------ILIDDINDSRPEFLNPIQTVSVLESAEPGTVI----- 2193
Query: 651 PRNLSVVEEEANA-----FVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK 705
N++ ++ + N VG V D D + Q N N GS+
Sbjct: 2194 -ANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN-------TGSVMVKSP 2245
Query: 706 LNREVRDYYELVVVATDGAVH-PRHS----TLTLAIKVLDIDDNSPVFTNSTYTVLVE-- 758
+NRE+ YE+ + D A P S L + VLD++DN+P F T +E
Sbjct: 2246 MNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERI 2305
Query: 759 -ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT-GELSLLRSLDYEAF 814
E GTT++ + A D D G N V+Y + + L + G++ R++DYE
Sbjct: 2306 LEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE-- 2363
Query: 815 PDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGT 872
+ + F V A D PP A + V ++ D+ND P+F + Y+ V D GT
Sbjct: 2364 --EVHWLNFTVRASD--NGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
Query: 873 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 932
I TV A DAD + + Y + D + S F + +G + +L+ E +
Sbjct: 2420 IILTVTATDADSGNF--ALIEYSLGDGE-----SKFAINPTTGDIYVLSSLDREKKDHYI 2472
Query: 933 LVVVAFDDGEPVMS----SSATVKILVLHPGEI------PRFTQEEYRPPPVSELATKGT 982
L +A D+ V S +S V I VL + P+F+ Y P T
Sbjct: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI--T 2530
Query: 983 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1042
M+ N + YS+ G + F ++ +G++ PL SY + SL
Sbjct: 2531 MMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQ-----SY----EKFSLT 2580
Query: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK--KFYIGGVSEDARMFTSVLRVKATDK 1100
VV + P T + +E+ D N++ PVF + I + E+ + ++V V ATDK
Sbjct: 2581 VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK 2640
Query: 1101 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1155
D G + Y + E F+++ +GLI+TA ++ + ++A+D
Sbjct: 2641 DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASD 2695
Score = 191 bits (484), Expect = 8e-48
Identities = 217/830 (26%), Positives = 353/830 (42%), Gaps = 126/830 (15%)
Query: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
Query: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
Query: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
Query: 566 TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPD 625
T+ ++ + Y LTV A D ST
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLST----------------------------- 218
Query: 626 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYS 684
A + I++TDV D P+F LP + ++ E V + A D D G + Y+
Sbjct: 219 ---LANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT 274
Query: 685 L--GNFNNLFRITSNGSIYTA-VKLNREVRDYYELVVVATDGAV-----HPRHSTLTLA- 735
+ GN N++F + + T L+RE Y ++ G P +T+T
Sbjct: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
Query: 736 -IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI---LQIEAKDVDLGANVSYRI-RSPEV 790
I V+DI+DN+P F +S Y+V + E G + +Q+ KD +LG N + +
Sbjct: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
Query: 791 KHFFALHPFTGE------LSLLRSLDYEAFPDQEASITFLVEAFDIYG--TMPP--GIAT 840
H F + P + + + + LDYE + FD++ ++P G A
Sbjct: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---------FDLFANESVPDHVGYAK 445
Query: 841 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 900
V + + + ND P+FS+ +Y + + GT + TV A D D V Y D
Sbjct: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF--GEVSYFFSD-- 501
Query: 901 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960
F +++D+G ++ L+ E F L ++A D G + + +L ++
Sbjct: 502 ---DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVN-DN 557
Query: 961 IPRFTQEEY------RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF---GI 1011
+P F ++ Y P V++L + + N I YSIVS + ++ +
Sbjct: 558 VPTFQKDAYVGALRENEPSVTQLV---RLRATDEDSPPNNQITYSIVSASAFGSYFDISL 614
Query: 1012 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1071
GVI V+ PLDYE ++ ++ L V+ + P ++T V IE+ DEN++PP
Sbjct: 615 YEGYGVISVSRPLDYEQISNGLI-----YLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
Query: 1072 VFQKKFYIGGVSEDARMFTSVLRVKATDKDT----GNYSVMAYRLIIPPIKEGKEGFVVE 1127
F K Y V E+ +VL + ATD D G S++ Y L EG F +
Sbjct: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSL------EGSTQFRIN 722
Query: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1177
+G I T L +S + V A D G G + K + + LD+
Sbjct: 723 ARSGEITTTSLLDRETKSEYILIVRAVDG-GVGHNQKTGIATVNITLLDI 771
Score = 89.0 bits (219), Expect = 4e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
Query: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
Query: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
PN I +R L + + A D+D + + YS L
Sbjct: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
Query: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
Query: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
Query: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
Query: 548 IL 549
IL
Sbjct: 2885 IL 2886
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 279 bits (713), Expect = 2e-74
Identities = 274/956 (28%), Positives = 407/956 (42%), Gaps = 125/956 (13%)
Query: 138 RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
R RN N+ P F+ SY ATV E P GT + A D D+G G++EY +
Sbjct: 171 RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
Query: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
D SN F + +TG + + L+ E K+ + + A D RR+ TLT+ V
Sbjct: 225 DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
Query: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
D +D P+F Q LR E+ ++T ++A D D PP
Sbjct: 281 DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
Query: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
+ ILY +L G+ F + PR+ + PV+R+ + + L ++A P P
Sbjct: 321 N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
Query: 377 --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
A + + + D+N+ +P F+ Y + E GA + LR+ A D+D
Sbjct: 379 RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
Query: 435 DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490
+ + F + QTG L ++ P+D E + YT + A DG + +
Sbjct: 430 SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549
+V +QV+D NDN P F + V + G V+ + A+DAD G N + Y +
Sbjct: 487 VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
Query: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRES 609
VG F IN TG I++A ++ RE
Sbjct: 547 VGHDFPFTINNGTGWISVAAELD----------------------------------REE 572
Query: 610 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVG 666
D Y + A D G P T++A+V++ V DVNDN P F P + E+A V
Sbjct: 573 VDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVV 630
Query: 667 QVKATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDG 723
V A D DA + GN N F ITS G + A+ L+ ++ Y L V A+DG
Sbjct: 631 TVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG 690
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY 783
R T + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N
Sbjct: 691 T---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARI 747
Query: 784 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 843
+ F + TG ++ LDYE + S T + A D + +
Sbjct: 748 TYFMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEI 803
Query: 844 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQ 900
+V D+ND P F + Y+G V D T + + A D D GL RV Y DD
Sbjct: 804 LVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD 861
Query: 901 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960
F VE SG V T L+ E + L A D G P + V + VL +
Sbjct: 862 -----GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVND 916
Query: 961 IPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITG 1016
P +++ V E + G V ++A N I+Y IV GN + F ++ +G
Sbjct: 917 NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSG 976
Query: 1017 VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1072
+ LDYE R YVL +QA S +V + A V++ + D N++PPV
Sbjct: 977 ELTALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
Score = 264 bits (674), Expect = 7e-70
Identities = 258/930 (27%), Positives = 419/930 (45%), Gaps = 110/930 (11%)
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPR 336
+P +YQA +PE N TP + R I P G L Y++ +
Sbjct: 182 QPPSYQATVPE-------NQPAGTP----VASLRAIDPDEGEAGRLEYTMDALFDSRSNQ 230
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPYF 395
FF + P T ++ E ++R+ + A QD+G P A A L I + D N+ P F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 396 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---VF 452
Y+ + E+ VG + L + A D D + L S VF
Sbjct: 290 EQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEVF 340
Query: 453 TVT-QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTP 507
+ ++G+ R PVDREE ++Y ++ A D ++ P V + V D NDN P
Sbjct: 341 EIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP 397
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLIT 566
F E Y V V D+ PG V+++TA D D+GSN + Y I+ G A+G F ++ TG +
Sbjct: 398 QFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALD 457
Query: 567 IAPGVEMIVGRTYALTVQAADNA-PPAERSTGILTLGKALDRESTDRYILIITASDGRPD 625
+ ++ + Y L V+A D PP +G++T
Sbjct: 458 VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVT------------------------- 492
Query: 626 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYS 684
+ V D+NDNAP+F P +V+E + V V+A D DAG N ++ Y
Sbjct: 493 --------VQVLDINDNAPIF-VSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYR 543
Query: 685 LGNFNNLFRITSN---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 741
L + F T N G I A +L+RE D+Y V A D ++ ++++ VLD+
Sbjct: 544 LAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDV 603
Query: 742 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTG 801
+DN+P FT YTV + E+ GT+++ + A D D + ++Y+I S ++ F++ +G
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
Query: 802 E--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRI 859
+SL LDY+ E V A D GT A + V V D N + PVF
Sbjct: 664 GGLVSLALPLDYKL----ERQYVLAVTASD--GTR-QDTAQIVVNVTDANTHRPVFQSSH 716
Query: 860 YKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT 919
Y V D GT + + A D D +R+ Y ++D P F ++ D+G V T
Sbjct: 717 YTVNVNEDRPAGTTVVLISATDEDTG--ENARITYFMED-SIPQ----FRIDADTGAVTT 769
Query: 920 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 978
+ L+ E + L + A D+G P S + ++ILV + P+F ++ Y+ V E
Sbjct: 770 QAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQ-GSVYEDV 828
Query: 979 TKGTMVGVISA----AAINQSIVYSIVSGNEED-TFGINNITGVIYVNGPLDYETRTSYV 1033
T V ISA + +N + Y+ G++ D F + + +G++ LD E YV
Sbjct: 829 PPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYV 888
Query: 1034 LRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1093
LR A + +P +V + + D N++PPVF++ + V E++ + +V
Sbjct: 889 LRAYA-------VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA 941
Query: 1094 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1153
RV ATD D G + + Y+++ I E F ++ ++G + + R + + A
Sbjct: 942 RVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIFSGELTALVDLDYEDRPEYVLVIQA 998
Query: 1154 TDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
T L +A V V ++++ D ++ N
Sbjct: 999 T---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
Score = 245 bits (626), Expect = 3e-64
Identities = 265/1014 (26%), Positives = 452/1014 (44%), Gaps = 134/1014 (13%)
Query: 39 PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95
PP+ + E GT + I +G AG + T++ + + +DPV +
Sbjct: 183 PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
Query: 96 LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154
+T LDR+ ++ + Q + ++ + I+V D ND+ P F+ + Y
Sbjct: 242 --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
Query: 155 TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213
++ E VG + T ATD D PN I Y +++ + P ++ FEI +G
Sbjct: 297 SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
Query: 214 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
I R ++ E+ Y + ++A+D+ ++ R+TT + + V D +D P F V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
Query: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333
R E++ P + A D+D+ + YSI+ G
Sbjct: 408 VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
Query: 334 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392
F++ +T L ++ P++ + +++ L ++A+ PL +GL +++LD N+ +
Sbjct: 446 Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
Query: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452
P F +Q +LES P+G + L + A+D D D E L + F
Sbjct: 503 PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 453 TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507
T+ T ++++ +DREE Y+F + A D P + V++ V+D NDN P
Sbjct: 554 TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564
TF + Y V + D G SV+ ++AVD D ++ ITY+I G + F I + GL
Sbjct: 609 TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 565 ITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRP 624
+++A L L L+R+ Y+L +TASDG
Sbjct: 667 VSLA------------------------------LPLDYKLERQ----YVLAVTASDGTR 692
Query: 625 DGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHY 683
T+ VN VTD N + PVF + N++ + A V + ATD D G N ++ Y
Sbjct: 693 QDTAQIVVN--VTDANTHRPVFQSSHYTVNVN-EDRPAGTTVVLISATDEDTGENARITY 749
Query: 684 SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
+ + FRI ++ G++ T +L+ E + Y L + A D + + T L I V D++
Sbjct: 750 FMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVN 809
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR-SPEVKHFFALHPF 799
DN+P F +Y V E++P T++LQI A D D G N V Y + + F +
Sbjct: 810 DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
Query: 800 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA--TVTVIVKDMNDYPPVFSK 857
+G + LR L D+E +++ A+ + MPP VTV V D+ND PPVF +
Sbjct: 870 SGIVRTLRRL------DRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQ 923
Query: 858 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 917
+ V ++ G + V A D D +++ Y++ + P +F+++ SG +
Sbjct: 924 DEFDVFVEENSPIGLAVARVTATDPDEG--TNAQIMYQIVEGNIP---EVFQLDIFSGEL 978
Query: 918 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL----HPGEIPRFTQEEYRPPP 973
V+L+ E + LV+ A P++ S ATV + +L +P + F
Sbjct: 979 TALVDLDYEDRPEYVLVIQA--TSAPLV-SRATVHVRLLDRNDNPPVLGNFEILFNNYVT 1035
Query: 974 VSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1025
+ G +G + A I+ S+ YS GNE +N TG + ++ LD
Sbjct: 1036 NRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 229 bits (583), Expect = 3e-59
Identities = 235/834 (28%), Positives = 356/834 (42%), Gaps = 103/834 (12%)
Query: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443
N +P F PSYQ + E+ P G ++ + A+D D +E T D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501
N + S+ VT +T + +DRE + T+ F +TA D + S + I V D
Sbjct: 227 RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
ND+ P F + Y + ++ G V+ + A D D N I Y +L G+ G F
Sbjct: 282 TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNA-PPAERSTGILTLGKALDRESTDRYILI 616
I+ +G+I V+ +Y LTV+A+D P RST
Sbjct: 342 IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRST-------------------- 381
Query: 617 ITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPD 674
TA V + V D NDNAP F R + V E+ A V +V A+D D
Sbjct: 382 ------------TAAVFLSVEDDNDNAPQFSE--KRYVVQVREDVTPGAPVLRVTASDRD 427
Query: 675 AGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 731
G N VHYS+ GN F + G++ L+ E Y L V A DG P +
Sbjct: 428 KGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNV 487
Query: 732 LTL-AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 790
L ++VLDI+DN+P+F ++ + V E++P G +L ++A D D G N R V
Sbjct: 488 SGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGV 547
Query: 791 KHF--FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM 848
H F ++ TG +S+ LD E + +F VEA D A+V+V V D+
Sbjct: 548 GHDFPFTINNGTGWISVAAELDRE----EVDFYSFGVEARDHGTPALTASASVSVTVLDV 603
Query: 849 NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIF 908
ND P F++ Y + DA GT + TV A D D S + Y++ SI
Sbjct: 604 NDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD----AHSVITYQITSGNTRNRFSIT 659
Query: 909 EVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEE 968
+ G V + L+ + + L V A D +A + + V Q
Sbjct: 660 S-QSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTDANTHRPVFQSS 715
Query: 969 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1024
+ V+E GT V +ISA N I Y + + F I+ TG + L
Sbjct: 716 HYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAEL 773
Query: 1025 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1084
DYE + SY L + A + +P KS+T + I + D N++ P F + Y G V E
Sbjct: 774 DYEDQVSYTLAITA-------RDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYE 826
Query: 1085 DARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRR 1144
D FTSVL++ ATD+D+G + Y +G F+VE+ +G+++T
Sbjct: 827 DVPPFTSVLQISATDRDSGLNGRVFY--TFQGGDDGDGDFIVESTSGIVRTLRRLDRENV 884
Query: 1145 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTE 1198
+ + + A D KG+ + V LD V++ PP + + + E
Sbjct: 885 AQYVLRAYAVD---KGMPPARTPMEVTVTVLD----VNDNPPVFEQDEFDVFVE 931
Score = 137 bits (346), Expect = 8e-32
Identities = 164/636 (25%), Positives = 261/636 (41%), Gaps = 59/636 (9%)
Query: 641 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-----GNFNNLFRIT 695
+ AP F P + + A V ++A DPD G G++ Y++ N F +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 696 S-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 754
G++ TA +L+RE + + V A D + R + TL I V D +D+ PVF Y
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYK 295
Query: 755 VLVEENLPAGTTILQIEAKDVDL--GANVSYRI---RSPEVKHFFALHPFTGELSLLRSL 809
+ ENL G +L + A D D AN+ YR+ F + P +G + +
Sbjct: 296 ESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 810 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIYKGMVAPD 867
D E + S VEA D P T V V+D ND P FS++ Y V D
Sbjct: 356 DRE----EVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 868 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 927
G P+ V A D D + V Y + F ++ +G + L+ E
Sbjct: 412 VTPGAPVLRVTASDRDKGS--NAVVHY---SIMSGNARGQFYLDAQTGALDVVSPLDYET 466
Query: 928 TTIFKLVVVAFDDGEPVMSSSA---TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMV 984
T + L V A D G P +S+ + TV++L ++ P F ++ V E G +V
Sbjct: 467 TKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDIN-DNAPIFVSTPFQ-ATVLESVPLGYLV 524
Query: 985 GVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADS 1040
+ A A N + Y + + F INN TG I V LD E Y V+A
Sbjct: 525 LHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEA-- 582
Query: 1041 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1100
+ P+ + +A V + + D N++ P F + Y ++EDA + TSV+ V A D+
Sbjct: 583 -----RDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDR 637
Query: 1101 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGK 1159
D +SV+ Y+ I + ++ GL+ A+ L + + R Y V+A
Sbjct: 638 DA--HSVITYQ-ITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQY----VLA------ 684
Query: 1160 GLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIG 1219
V S + D IV NV + + + +++ G VV+ S
Sbjct: 685 -------VTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISAT 737
Query: 1220 ARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNEL 1255
G+ + + + + + ID T + EL
Sbjct: 738 DEDTGENARITYFMEDSIPQFRIDADTGAVTTQAEL 773
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 271 bits (694), Expect = 3e-72
Identities = 300/1101 (27%), Positives = 464/1101 (42%), Gaps = 133/1101 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
D I YS+ + P + N+ + +KA
Sbjct: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
Query: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
Query: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
Query: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Y + +Q + F I+ TG I+ ++ T+ +V A+D
Sbjct: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASD------------- 2897
Query: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
LG+A +STA V++ VTD+NDNAPVF + R +
Sbjct: 2898 LGEAFSL-------------------SSTALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
Query: 661 ANAFVGQVKATDPD-AGINGQVHYSL--GNFNNLFR---ITSNGSIYTAVKLNREVRDYY 714
V + D D + +N QV Y + GN F + S +Y L+RE +D Y
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
Query: 715 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 774
L + ATDG + + + V D++DNSPV YT L+ E++P+ IL++ AKD
Sbjct: 2999 FLNITATDGLF---VTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKVSAKD 3055
Query: 775 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 832
D+G+N + Y + FF L P +GEL L LD E P + + +A D G
Sbjct: 3056 ADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERIP----VYSLMAKATDGGG 3110
Query: 833 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 892
+ + +I++D+ND PPVFS Y V + +T V A D D G+ V
Sbjct: 3111 RFCQ--SNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD-IGINRKVV 3167
Query: 893 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGE-PVMSSSATV 951
D +F ++ SG +I L+ E + + + V A D +SS TV
Sbjct: 3168 YSLADSA-----GGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTV 3222
Query: 952 KILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA----INQSIVYSIVSGNEED 1007
I VL + P + V E + GT V + A + N I Y I SGNE+
Sbjct: 3223 TITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQG 3282
Query: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
F IN TG I V+ LDYE + L V+A + P+ S A V I + D N
Sbjct: 3283 KFKINPKTGGISVSEVLDYELCKRFYLVVEA-------KDGGTPALSAVATVNINLTDVN 3335
Query: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1127
++PP F + Y +SEDA + SV+ + A D D+ + + ++ + F V+
Sbjct: 3336 DNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIV---NGDRDNEFTVD 3392
Query: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1187
GL+K R S + V A D +S A V + + + D + + T
Sbjct: 3393 PVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYT 3452
Query: 1188 LVEKKIEDL-TEILDRYVQEQ 1207
V ++ + + T IL V ++
Sbjct: 3453 AVIQENKPVGTSILQLVVTDR 3473
Score = 271 bits (693), Expect = 4e-72
Identities = 294/1106 (26%), Positives = 480/1106 (43%), Gaps = 142/1106 (12%)
Query: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
Query: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLVT-----QVQAIDPDDGANSRITYSL-YSE 2642
Query: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
+ D EI D +++ + N N+ + T + V
Sbjct: 2643 ASVSVADLLEI-----------------DPDNGWMVTKGN-----FNQLKNTVLSFFVKA 2680
Query: 256 LDGD-----DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
+DG L P+++ VL P T +P + I I +
Sbjct: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPR--FFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
I P + + +S + G + + F + T + L + ++R+ FH K
Sbjct: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
Query: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
Query: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
Query: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
Query: 541 NGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
N +++Y I G +G F + GL+ +S +
Sbjct: 2957 NRQVSYHITGGNPRGRFAL----GLV----------------------------QSEWKV 2984
Query: 600 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 659
+ + LDRE D Y L ITA+DG + A V + V+DVNDN+PV D L +
Sbjct: 2985 YVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDI 3042
Query: 660 EANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIYTAVKLNREVRDYYELV 717
+N + +V A D D G NG + YSL N F +G + T L+RE Y L+
Sbjct: 3043 PSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLM 3102
Query: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 777
ATDG S + L ++ D++DN PVF++ Y V EN + +++A D D+
Sbjct: 3103 AKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDI 3160
Query: 778 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY-GTM 834
G N V Y + + F++ +G + L + LD E Q++S V A D G
Sbjct: 3161 GINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQSSYNISVRATDQSPGQS 3215
Query: 835 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
+ TVT+ V D+ND PPVF +R Y V D GT + V+A D
Sbjct: 3216 LSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLI 3275
Query: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKIL 954
R + Q F++ +G + L+ E F LVV A D G P +S+ ATV I
Sbjct: 3276 RSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNIN 3330
Query: 955 VLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----NQSIVYSIVSGNEEDTF 1009
+ + P +F+Q+ Y +SE A G V ++ A + N I +SIV+G+ ++ F
Sbjct: 3331 LTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEF 3389
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
++ + G++ V LD E + Y L VQA + +P+ S+TA V I+I D N++
Sbjct: 3390 TVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAMSSTATVNIDISDVNDN 3442
Query: 1070 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1129
PVF Y + E+ + TS+L++ TD+D+ + I+ +E E FV++ +
Sbjct: 3443 SPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEE--EEFVLDPH 3500
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATD 1155
G++++A++F + + V A D
Sbjct: 3501 -GILRSAVVFQHTESLEYVLCVQAKD 3525
Score = 269 bits (687), Expect = 2e-71
Identities = 312/1173 (26%), Positives = 523/1173 (44%), Gaps = 167/1173 (14%)
Query: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
Query: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
++ V ++ + D ND SP F SY V E PVGT I D D G GQ
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI-----AWLETHDPDLGLGGQ 970
Query: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
Query: 247 TTTTLTVDVLDGDD--LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
Query: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Query: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
Query: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGL--ITTTSRKLDREQQAEHFLEVT 1225
Query: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
Query: 539 GSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN
Sbjct: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDN--------- 1334
Query: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV---FD-PYLPRN 653
GRP +STA ++I +P+ FD P+ N
Sbjct: 1335 ------------------------GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFY--N 1368
Query: 654 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYTAVKLNREV 710
+V+E + + V + P N + + + GNF++ F G+I A L+ E
Sbjct: 1369 FTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQ 1425
Query: 711 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 770
R Y + V TDG + + IKVLD +DN P F+ Y V + E++ T ILQI
Sbjct: 1426 RSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQI 1482
Query: 771 EAKDVDLGANVSYRIRS---PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 827
EA D D +SY + S F + P TG L LD+EA +I +
Sbjct: 1483 EATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQE 1542
Query: 828 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 887
F +A V V V+D ND+ P F+ +Y+ V A G+ + V A D D G
Sbjct: 1543 F----PYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKD-KGE 1597
Query: 888 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVVVAFDDGEP 943
A + ++ ++F++E V+ + + +EP TT+ F L + D G P
Sbjct: 1598 NAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSIKVTDQGSP 1649
Query: 944 VMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1002
MS++A V+I V + P+F ++Y+ V+E GT V +ISA + +++Y +
Sbjct: 1650 PMSATAIVRISVTMSDNSHPKFIHKDYQ-AEVNENVDIGTSVILISAIS-QSTLIYEVKD 1707
Query: 1003 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1062
G+ F IN +GVI LDYE +SY L +QA ++ + +N A V I+
Sbjct: 1708 GDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN---------ATVNIQ 1758
Query: 1063 IQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSVMAYRLIIP 1115
I DEN++ PVF Y G +SE A + S L ++ATD D+ +++ Y+++
Sbjct: 1759 IVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIV-- 1816
Query: 1116 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1175
K+ F V++ TG I+T + ++F F V D L+ ++ V ++
Sbjct: 1817 -ESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV------EV 1869
Query: 1176 DMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1208
+++V N P + + + + +L YV ++
Sbjct: 1870 NIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
Score = 249 bits (637), Expect = 1e-65
Identities = 249/888 (28%), Positives = 400/888 (45%), Gaps = 106/888 (11%)
Query: 322 ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAG 380
+L++I G + F++ T +L +L P++R+ H L+ D G+P + +
Sbjct: 761 VLFTISDGNTDSC---FNIDMETGQLKVLMPMDRE-HTDLYLLNITIYDLGNPQKSSWRL 816
Query: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE 440
L I + D N+ SP F SY ILES+ +G I +++ A DKD+ +
Sbjct: 817 LTINVEDANDNSPVFIQDSYSVNILESSGIGTEI---------IQVEARDKDLGSNGEVT 867
Query: 441 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV--IVNIQ 498
+ L D + TGI + + +DRE + Y+ I A D + + + +V ++
Sbjct: 868 YSV-LTDTQQFAINSSTGI---VYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLK 923
Query: 499 VM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDF 556
V D ND +P F SY V V D+ G + L D D G G++ Y ++ G F
Sbjct: 924 VFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRF 983
Query: 557 IINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILI 616
I+K +G I L K LD E Y L
Sbjct: 984 EIDKASGAIR----------------------------------LSKELDYEKQQFYNLT 1009
Query: 617 ITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKA 670
+ A D GRP S+ + V + V DVN+N + PY P V + N+ +G QV A
Sbjct: 1010 VRAKDKGRPVSLSSVSFVEVEVVDVNEN--LHTPYFPDFAVVGSVKENSRIGTSVLQVTA 1067
Query: 671 TDPDAGINGQVHYSLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHP 727
D D+G +G++ YS+ + + L R + +G I A L+RE Y L V ATD V P
Sbjct: 1068 RDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
Query: 728 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI 785
+ST+ + I+V D++DN+P+ + Y +V EN P +++QI+A+D D +N ++YRI
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
Query: 786 RSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 844
S ++FFA++ TG ++ R LD E Q+A V D G P +T+ V+
Sbjct: 1188 TSGNPQNFFAINIKTGLITTTSRKLDRE----QQAEHFLEVTVTD--GGPSPKQSTIWVV 1241
Query: 845 VK--DMNDYPPVFSKRIYKGMVAPD---AVKGTPITTVYAEDADPPGLPASRVRYRVDDV 899
V+ D ND P F +++Y+ + P+ +G PI +A D D P + + Y + D
Sbjct: 1242 VQVLDENDNKPQFPEKVYQ-IKLPERDRKKRGEPIYRAFAFDRDEG--PNAEISYSIVDG 1298
Query: 900 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-- 957
F ++ +G V +R I L + A D+G P SS+A + I +
Sbjct: 1299 N---DDGKFFIDPKTGMVSSRKQFTAGSYDI--LTIKAVDNGRPQKSSTARLHIEWIKKP 1353
Query: 958 -PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITG 1016
P IP E + V E +VGV+S N + + IV GN + F G
Sbjct: 1354 PPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVG 1413
Query: 1017 VIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1075
I + PLD E R+ Y + V+ D V + +V+I++ D N++ P F +
Sbjct: 1414 TIVIAKPLDAEQRSIYNMSVEVTDGTNVAV-----------TQVFIKVLDNNDNGPEFSQ 1462
Query: 1076 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1135
Y +SED T +L+++ATD+D + I I K F ++ TG++ T
Sbjct: 1463 PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRK--FRIDPSTGVLYT 1520
Query: 1136 AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
A + + ++ D A V+V+V + D +N
Sbjct: 1521 AERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTN 1568
Score = 242 bits (617), Expect = 3e-63
Identities = 297/1179 (25%), Positives = 474/1179 (40%), Gaps = 189/1179 (16%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQV--QCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
+ +TG DR+ ++ +VV+ + + +V ++ VR+ + D NDNSP F YY
Sbjct: 2035 IQTTGVPFDREE-QELYELVVEASRELDHLRVARVV---VRVNIEDINDNSPVFVGLPYY 2090
Query: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 213
A V GT I+ A D D GPNG++ YV+Q DD FEI +GN
Sbjct: 2091 AAVQVDAEPGTLIY-----QVTAIDKDKGPNGEVTYVLQ---DD---YGHFEIN-PNSGN 2138
Query: 214 IVLRKRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVP 272
++L++ N + Y V I A D + + +T++ + + + P+F
Sbjct: 2139 VILKEAFNSDLSNIEYGVTILAKD-----GGKPSLSTSVELPITIVNKAMPVF------- 2186
Query: 273 NTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE 332
+P Y A++ E I + PI +I N P + GI+Y I+ G P
Sbjct: 2187 ----DKPF-YTASVNE--------DIRMNTPILSI----NATSPEGQ-GIIYIIIDGDPF 2228
Query: 333 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL------ 386
+ F++ T L ++ P++ + + L I+A A G E+
Sbjct: 2229 ---KQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASD-------ALTGARAEVTVDLLVN 2278
Query: 387 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 446
D N+ P F P+Y + E++ +G T L++V++D D E+ K + +
Sbjct: 2279 DVNDNPPIFDQPTYNTTLSEASLIG---------TPVLQVVSIDADSENNKMVHYQIVQD 2329
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDAND 504
Y S + + + +D E Q T + + D S V+V+I + D ND
Sbjct: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
Query: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTG 563
N P F ++ Y+ YV G V + A DAD + Y IL G + F+++ +G
Sbjct: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
Query: 564 LITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKAL---------------DRE 608
+IT++ + + Y+L V +D + I LG L +
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENV 2509
Query: 609 STDRYILIITASDGRP-------------------------------------------- 624
+ ++ + A+DG P
Sbjct: 2510 AAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVS 2569
Query: 625 ------DGTSTAT---VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 675
DG T V ++V D NDNAP F R + V QV+A DPD
Sbjct: 2570 IFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDD 2629
Query: 676 GINGQVHYSL-----GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRH 729
G N ++ YSL + +L I NG + T N+ V A DG + +H
Sbjct: 2630 GANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKH 2689
Query: 730 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI--LQIEAKDVDLGANVSYRIRS 787
S + + I VL + P FT S Y+ + E+ G+T+ L+I + V+
Sbjct: 2690 SLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPE 2749
Query: 788 PEVKHFFALHPFTGELSLLRSLDYEAFP--DQEASITFLVEAFDIYGTMPPGIATVTVIV 845
F + TG + L + LD E P + + T ++ DI T+ V + V
Sbjct: 2750 NNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTV-----DVDIKV 2804
Query: 846 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYP 904
D+ND PVF Y ++ GT +T V A D D +V Y + D Q
Sbjct: 2805 LDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGA--NGQVTYSLHSDSQPEKV 2862
Query: 905 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGE-IP 962
F ++ ++G + T +L+ E F VVA D GE +SS+A V + V + P
Sbjct: 2863 MEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAP 2922
Query: 963 RFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFGINNITG- 1016
F QE YR V E G +V V+S + +N+ + Y I GN F + +
Sbjct: 2923 VFAQEVYR-GNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSE 2981
Query: 1017 -VIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1074
+YV PLD E + Y L + A D L V A V + + D N++ PV
Sbjct: 2982 WKVYVKRPLDREEQDIYFLNITATDGLFV-----------TQAMVEVSVSDVNDNSPVCD 3030
Query: 1075 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1134
+ Y + ED +L+V A D D G+ + Y L G F ++ +G +K
Sbjct: 3031 QVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL----YGSGNSEFFLDPESGELK 3086
Query: 1135 TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1173
T L R + ATD G+ +++ VN
Sbjct: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILEDVN 3125
Score = 231 bits (589), Expect = 5e-60
Identities = 275/1052 (26%), Positives = 440/1052 (41%), Gaps = 161/1052 (15%)
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
Query: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
Query: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
Query: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
Query: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITAS 620
+G+IT AAD LDRE+ Y L + A+
Sbjct: 1096 ESGVIT------------------AAD----------------ILDRETMGSYWLTVYAT 1121
Query: 621 D-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 679
D G ST V I V DVNDNAP+ + + + + V Q++A DPD+ N
Sbjct: 1122 DRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNE 1181
Query: 680 QVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYELVVVATDGAVHPRHSTLTLA 735
++ Y + GN N F I + T KL+RE + + L V TDG P+ ST+ +
Sbjct: 1182 KLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVV 1241
Query: 736 IKVLDIDDNSPVFTNSTYTVLVEE--NLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK 791
++VLD +DN P F Y + + E G I + A D D G N +SY I
Sbjct: 1242 VQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDD 1301
Query: 792 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
F + P TG +S + ++ ++A D P +T + ++ +
Sbjct: 1302 GKFFIDPKTGMVSSRKQFTAGSYD------ILTIKAVD--NGRPQKSSTARLHIEWIKKP 1353
Query: 852 PP-----VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS 906
PP F + Y V + V + A+ P + + + F S
Sbjct: 1354 PPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTP------LWFDIVGGNFD---S 1404
Query: 907 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 966
F+ E+ G ++ L+ E +I+ + V DG V + +K+L + P F+Q
Sbjct: 1405 AFDAEKGVGTIVIAKPLDAEQRSIYNM-SVEVTDGTNVAVTQVFIKVLDNNDNG-PEFSQ 1462
Query: 967 EEYRPPPVSELATKGTMVGVISAAAINQS-----IVYSIVSGNEEDTFGINNITGVIYVN 1021
Y +SE T + I A ++ V+S + F I+ TGV+Y
Sbjct: 1463 PNY-DVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521
Query: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081
LD+E + ++L + E P + N A+V + ++D N+H P F Y
Sbjct: 1522 ERLDHEAQDKHILNIMVRDQE-------FPYRRNLARVIVNVEDANDHSPYFTNPLYEAS 1574
Query: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLF 1139
V E A + ++VL+V A DKD G + + Y I+ G G F +E G+I
Sbjct: 1575 VFESAALGSAVLQVTALDKDKGENAELIY-----TIEAGNTGNMFKIEPVLGIITICKEP 1629
Query: 1140 HNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1171
F + TD +S A V +SV
Sbjct: 1630 DMTTMGQFVLSIKVTDQGSPPMSATAIVRISV 1661
Score = 229 bits (585), Expect = 1e-59
Identities = 285/1057 (26%), Positives = 456/1057 (43%), Gaps = 157/1057 (14%)
Query: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTF----EIPLMLTGNIVLRKRLNYED-KTRYFVII 232
D+DDG NG+IE V DP D F E + I RK++++E Y + +
Sbjct: 289 DLDDGANGEIESV-SIVAGDPL--DQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTL 345
Query: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN-TRDCRPL-----TYQAAI 286
QA D+ G L V + N TRD P+ Y +I
Sbjct: 346 QAKDK--------------------GSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSI 385
Query: 287 PELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE 346
E P + I+ P + ID + + P D +F ++PR+
Sbjct: 386 SEFSPPGVVVAIVKLSP-EPIDVEYKLSPGEDAV----------------YFKINPRSGL 428
Query: 347 LSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILE 406
+ P+N + + L + ++ + A + I I D N+ +P F P Y Y+ E
Sbjct: 429 IVTARPLNTVKKEVYKLEVTNKEGD-----LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 407 SAPVGATISDSLNLTSPLRIVALDKDIEDT-----KDPELHLF---LNDYTSVFTVTQTG 458
S PVG TS L + A DKD + L+L +N +T V + T+
Sbjct: 484 SVPVG---------TSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEE- 533
Query: 459 ITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEISY 514
+D E + Y F + A D + V V I++ + NDN+P F +++
Sbjct: 534 ----------LDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
Query: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEM 573
+ D G + ++A+D DE + Y+I+ G + G F +N +G++ + +
Sbjct: 584 QGVISYDFPVGGHITAVSAIDIDELEL--VKYKIISGNELGFFYLNPDSGVLQLKKSLTN 641
Query: 574 --IVGRTYALTVQAADN---APPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTS 628
I +AL + A D A P + +L GK + + R + + +
Sbjct: 642 SGIKNGNFALRITATDGENLADPMSINISVLH-GKVSSKSFSCRETRVAQKLAEKLLIKA 700
Query: 629 TATVNIVVTD-------VNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQ 680
A + + D +N P FD P +++V E+ A + ++KA D D+G NG+
Sbjct: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
Query: 681 VHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 737
V +++ GN ++ F I G + + ++RE D Y L + D + S L I
Sbjct: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTIN 820
Query: 738 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 795
V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N V+Y + + + FA
Sbjct: 821 VEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FA 878
Query: 796 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPP 853
++ TG + + LD E+ +A+ + +EA D G + T+ V + D+ND P
Sbjct: 879 INSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
Query: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEE 912
F Y V D GT I + E DP +VRY V+D FE+++
Sbjct: 935 AFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSLVNDYN-----GRFEIDK 987
Query: 913 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFT 965
SG + L+ E + L V A D G PV +SS + V++ V LH P F
Sbjct: 988 ASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047
Query: 966 QEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1021
V E + GT V ++A + + I YSI G+ F I++ +GVI
Sbjct: 1048 V----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAA 1103
Query: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081
LD ET SY L V A VV +T +VYIE++D N++ P+ + Y
Sbjct: 1104 DILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVEDVNDNAPLTSEPIYYPV 1156
Query: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLF 1139
V E++ SV++++A D D+ + + YR+ + F + TGLI T L
Sbjct: 1157 VMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFFAINIKTGLITTTSRKLD 1213
Query: 1140 HNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+ +F +V TD G S K + VV LD
Sbjct: 1214 REQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
Score = 221 bits (564), Expect = 4e-57
Identities = 266/1050 (25%), Positives = 442/1050 (42%), Gaps = 158/1050 (15%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
Query: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
++Y + T + AID D + + Y I+ G
Sbjct: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
Query: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
E+ ++++ Y +S P + + L +
Sbjct: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
Query: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
Query: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
Query: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++
Sbjct: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
Query: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
++TL LD DVND +P F P ++ V+
Sbjct: 919 VVTLKVFLD-------------------------------DVNDCSPAFIP-SSYSVKVL 946
Query: 658 EE-EANAFVGQVKATDPDAGINGQVHYSLGN-FNNLFRI-TSNGSIYTAVKLNREVRDYY 714
E+ + ++ DPD G+ GQV YSL N +N F I ++G+I + +L+ E + +Y
Sbjct: 947 EDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKELDYEKQQFY 1006
Query: 715 ELVVVATD-GAVHPRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIE 771
L V A D G S + ++V+D+++N +P F + V+EN GT++LQ+
Sbjct: 1007 NLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVT 1066
Query: 772 AKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
A+D D G + Y IR F++ +G ++ LD E S V A D
Sbjct: 1067 ARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETM----GSYWLTVYATD 1122
Query: 830 IYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 888
G +P V + V+D+ND P+ S+ IY +V ++ K + + AE DP
Sbjct: 1123 -RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAE--DPDSSS 1179
Query: 889 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV-NLNEEPTTIFKLVVVAFDDGEPVMSS 947
++ YR+ P + F + +G + T L+ E L V D G S
Sbjct: 1180 NEKLTYRITSGN---PQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQS 1236
Query: 948 SATVKILVLHPGE-IPRFTQEEYR-PPPVSELATKGTMVGVISA----AAINQSIVYSIV 1001
+ V + VL + P+F ++ Y+ P + +G + A N I YSIV
Sbjct: 1237 TIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIV 1296
Query: 1002 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1061
GN++ F I+ TG++ T SY D L + + P KS+TA+++I
Sbjct: 1297 DGNDDGKFFIDPKTGMVSSRKQF---TAGSY------DILTIKAVDNGRPQKSSTARLHI 1347
Query: 1062 EIQDENNHPPV---FQKKFYIGGVSEDARM 1088
E + P+ F + FY V E R+
Sbjct: 1348 EWIKKPPPSPIPLTFDEPFYNFTVMESDRV 1377
Score = 211 bits (537), Expect = 5e-54
Identities = 267/1071 (24%), Positives = 442/1071 (41%), Gaps = 154/1071 (14%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
+ D +D P F+P + ++ E+L V ++ D D +
Sbjct: 926 LDDVNDCSPAFIP-----------------SSYSVKVLEDLPVGTVIAWLETHDPDLGLG 968
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
+ YS++ DY F + + + L + ++ + Q ++L ++A +D G P
Sbjct: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRA-KDKGRP 1018
Query: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
Query: 549 LVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
G Q F IN TGLIT T + LDR
Sbjct: 1188 TSGNPQNFFAINIKTGLIT---------------------------------TTSRKLDR 1214
Query: 608 ESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-- 664
E + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 1215 EQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKRGE 1273
Query: 665 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 721
+ + A D D G N ++ YS+ GN + F I + ++ K Y L + A
Sbjct: 1274 PIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIKAV 1332
Query: 722 DGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEAKD 774
D + ST L I+ + SP+ F N +TV+ + + ++ ++ +
Sbjct: 1333 DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQPAN 1390
Query: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 834
L + I F G + + + LD E Q + VE D GT
Sbjct: 1391 TPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--GT- 1439
Query: 835 PPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 892
+A V +K D ND P FS+ Y ++ D + T I + A D D + V
Sbjct: 1440 --NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTV 1497
Query: 893 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 952
+D + F ++ +G + T L+ E L ++ D P + A V
Sbjct: 1498 HSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVI 1553
Query: 953 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007
+ V + P FT Y V E A G+ V ++A N ++Y+I +GN +
Sbjct: 1554 VNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGN 1612
Query: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
F I + G+I + D T +VL ++ + + P S TA V I + +
Sbjct: 1613 MFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTMSD 1665
Query: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FV 1125
N P F K Y V+E+ + TSV+ + A + T +I +K+G F
Sbjct: 1666 NSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGIFT 1715
Query: 1126 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+ Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1716 INPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
Score = 197 bits (501), Expect = 8e-50
Identities = 273/1130 (24%), Positives = 474/1130 (41%), Gaps = 174/1130 (15%)
Query: 41 ATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTG 100
A + ++ E SR GT ++ + + G D I+ S++D + + +
Sbjct: 1047 AVVGSVKENSRIGTSVLQ-VTARDEDSGRDGEIQYSIRDGSGLGRFS--IDDESGVITAA 1103
Query: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESYYATVNEL 159
+LDR+ + S + V ++ V + EV I V D NDN+P YY V E
Sbjct: 1104 DILDRE---TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMEN 1160
Query: 160 TPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
+P ++ A D D N ++ Y + NP + F + TG I
Sbjct: 1161 SPKDVSVI-----QIQAEDPDSSSNEKLTYRITSGNPQN------FFAINIKTGLITTTS 1209
Query: 219 R-LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
R L+ E + +F+ + D + + +T + V VLD +D P F V
Sbjct: 1210 RKLDREQQAEHFLEVTVTDGGPSPKQ---STIWVVVQVLDENDNKPQFPEKV-------- 1258
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
YQ +PE + PI +A DR+ P ++ I YSI+ G D +F
Sbjct: 1259 ----YQIKLPERDRKKRGEPIY-----RAFAFDRDEGPNAE---ISYSIVDGN--DDGKF 1304
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF-AGLHIEILDENNQSPY-- 394
F + P+T +S + +D++ DNG P + A LHIE + + SP
Sbjct: 1305 F-IDPKTGMVSSRKQFTAG---SYDILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPL 1360
Query: 395 -FTMPSYQGYILESAPVGATIS--DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
F P Y ++ES V + +PL + + + D E V
Sbjct: 1361 TFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAE--------KGV 1412
Query: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
T+ + +P+D E++ Y S+ DG + + I+V+D NDN P F +
Sbjct: 1413 GTIV---------IAKPLDAEQRSIYNMSVEVTDGTNVAVTQVF-IKVLDNNDNGPEFSQ 1462
Query: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 571
+YDV + D+ P ++Q+ A D DE +++Y T+ +
Sbjct: 1463 PNYDVTISEDVLPDTEILQIEATDRDE--KHKLSY-------------------TVHSSI 1501
Query: 572 EMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGR-PDGTSTA 630
+ I R + + + STG+L + LD E+ D++IL I D P + A
Sbjct: 1502 DSISMRKFRI-----------DPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLA 1550
Query: 631 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GN 687
V + V D ND++P F L SV E A + V QV A D D G N ++ Y++ GN
Sbjct: 1551 RVIVNVEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGN 1609
Query: 688 FNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSP 746
N+F+I I T K + + L + TD P +T + I V D++ P
Sbjct: 1610 TGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHP 1669
Query: 747 VFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLL 806
F + Y V EN+ GT+++ I A + + Y ++ ++ F ++P++G ++
Sbjct: 1670 KFIHKDYQAEVNENVDIGTSVILISAIS---QSTLIYEVKDGDINGIFTINPYSGVITTQ 1726
Query: 807 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAP 866
++LDYE + +S +++A ++ G ATV + + D ND PVF Y G ++
Sbjct: 1727 KALDYE----RTSSYQLIIQATNMAGM--ASNATVNIQIVDENDNAPVFLFSQYSGSLSE 1780
Query: 867 DA--------VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVI 918
A + +P+ + A DAD ++R V + F V+ +G +
Sbjct: 1781 AAPINSIVRSLDNSPL-VIRATDAD-----SNRNALLVYQIVESTAKKFFTVDSSTGAIR 1834
Query: 919 TRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE-- 976
T NL+ E F V D G P +++ + V++ + T PP ++
Sbjct: 1835 TIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNI-------EVTDVNDNPPVFTQAV 1887
Query: 977 ---LATKGTMVGV----ISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1025
+ T VGV +SA + + + YS++ G+ D F I++ +GV+ + +
Sbjct: 1888 FETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTIKN--N 1944
Query: 1026 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1085
++ Y+L V+ + +T+ V I +++ + F + FY +SE+
Sbjct: 1945 NLSKDHYMLIVKVSDGKFY----------STSMVTIMVKEAMDSGLHFTQSFYSTSISEN 1994
Query: 1086 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1135
T V V A + Y ++ P K F +++ +G+I+T
Sbjct: 1995 NTNITKVAIVNAVGNRLN--EPLKYSILNPGNK-----FKIKSTSGVIQT 2037
Score = 196 bits (499), Expect = 1e-49
Identities = 269/1126 (23%), Positives = 442/1126 (39%), Gaps = 203/1126 (18%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
Query: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
Query: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Y L + + DS + ++ L KD +++ D
Sbjct: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Query: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
LH + Y++ + T IT+ T
Sbjct: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
Query: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + +
Sbjct: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDL------- 2149
Query: 583 VQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDN 642
S Y + I A DG ST +V + +T VN
Sbjct: 2150 --------------------------SNIEYGVTILAKDGGKPSLST-SVELPITIVNKA 2182
Query: 643 APVFDPYLPRNLSVVEEE--ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGS 699
PVFD P + V E+ N + + AT P+ G ++ + G+ F I +
Sbjct: 2183 MPVFDK--PFYTASVNEDIRMNTPILSINATSPEG--QGIIYIIIDGDPFKQFNIDFDTG 2238
Query: 700 IYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 758
+ V L+ EV Y+L + A+D R + +T+ + V D++DN P+F TY +
Sbjct: 2239 VLKVVSPLDYEVTSAYKLTIRASDALTGAR-AEVTVDLLVNDVNDNPPIFDQPTYNTTLS 2297
Query: 759 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAF 814
E GT +LQ+ + D D N V Y+I +F + +G + R LD+E
Sbjct: 2298 EASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELV 2357
Query: 815 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 874
T V + D V + + D+ND PPVF++ IY+ V+ A +G +
Sbjct: 2358 ----QHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV 2413
Query: 875 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 934
T V A DAD R+ Y + + F ++ SG VIT N ++ +
Sbjct: 2414 TCVQASDADSSDF--DRLEY---SILSGNDRTSFLMDSKSG-VITLSNHRKQRMEPLYSL 2467
Query: 935 VVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATKGTMVGVISAA--- 990
V+ DG + +S+A V I VL P F+Q Y V E GT V + A
Sbjct: 2468 NVSVSDG--LFTSTAQVHIRVLGANLYSPAFSQSTY-VAEVRENVAAGTKVIHVRATDGD 2524
Query: 991 -AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1049
I Y+I++ +D F I++ G + LD E + + + L
Sbjct: 2525 PGTYGQISYAIINDFAKDRFLIDS-NGQVITTERLDRENPLE-------GDVSIFVRALD 2576
Query: 1050 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1109
++ V + + DEN++ P F Y V D V +V+A D D G S +
Sbjct: 2577 GGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRIT 2636
Query: 1110 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1155
Y L + ++ G + T F+ ++ + F V A D
Sbjct: 2637 YSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVD 2682
Score = 195 bits (495), Expect = 4e-49
Identities = 287/1166 (24%), Positives = 472/1166 (40%), Gaps = 158/1166 (13%)
Query: 37 GGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFL 96
G P +V+ID +S N +V +++ T ++ DY+ + +L
Sbjct: 2303 GTPVLQVVSIDADSENNK-MVHYQIVQDTY------------NSTDYFHIDSSSGLIL-- 2347
Query: 97 NSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHE-VRIVVRDRNDNSPTFKHESYYAT 155
T R+LD + + ++V+ I+ ++ V I + D NDN P F Y +
Sbjct: 2348 --TARMLDHEL---VQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESY 2402
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
V+EL P G + + D ++D D ++EY I L+GN
Sbjct: 2403 VSELAPRGHFVTCVQASDADSSDFD-----RLEYSI------------------LSGN-- 2437
Query: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
R ++ ++ VI +N R Q R +L V V DG +F V + R
Sbjct: 2438 --DRTSFLMDSKSGVITLSNHRKQ----RMEPLYSLNVSVSDG-----LFTSTAQV-HIR 2485
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
Y A + E V + A + +++ PG I D+
Sbjct: 2486 VLGANLYSPAFSQSTYVAE-----VRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFA 2540
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
+ + ++ E ++R+ + D+ I +G F + + ++DEN+ +P F
Sbjct: 2541 KDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQF 2600
Query: 396 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVT 455
Y+ + G ++ ++ A+D D D + + L SV
Sbjct: 2601 MTVEYRASVRADVGRGHLVT---------QVQAIDPD--DGANSRITYSLYSEASVSVAD 2649
Query: 456 QTGI---TRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFP 510
I ++ ++ + +F + A DG + + V I V+ P+F
Sbjct: 2650 LLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFT 2709
Query: 511 EISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 570
+ Y + D G +V L + + + + + G + + N G+ I
Sbjct: 2710 QSQYSFTIAEDTAIGSTVDTLRILPSQ-----NVWFSTVNGERPE---NNKGGIFVI--- 2758
Query: 571 VEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD--GRPDGTS 628
E+ TG + L K LDRE++ + + A+ + D
Sbjct: 2759 ----------------------EQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVF 2796
Query: 629 TATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNF 688
T V+I V D+NDN PVF+ + + + QV+A D D G NGQV YSL +
Sbjct: 2797 TVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSD 2856
Query: 689 N------NLFRITSN-GSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLD 740
+ F I SN G I T L+ E + VVA+D G ST ++++V D
Sbjct: 2857 SQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTD 2916
Query: 741 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALH 797
I+DN+PVF Y V+E+ P G + + D D+ VSY I + FAL
Sbjct: 2917 INDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALG 2976
Query: 798 PFTGE--LSLLRSLDYEAFPDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPP 853
E + + R LD E E I FL + A D ++ T A V V V D+ND P
Sbjct: 2977 LVQSEWKVYVKRPLDRE-----EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSP 3027
Query: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 913
V + Y ++ D I V A+DAD +RY + + S F ++ +
Sbjct: 3028 VCDQVAYTALLPEDIPSNKIILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPE 3081
Query: 914 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPP 973
SG + T L+ E ++ L+ A D G S+ + IL P F+ + Y
Sbjct: 3082 SGELKTLALLDRERIPVYSLMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCV 3140
Query: 974 VSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1030
ATK + V + IN+ +VYS+ + + F I++ +G+I + PLD E ++
Sbjct: 3141 YENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQS 3199
Query: 1031 SYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFT 1090
SY + V+A S S+ V I + D N++PPVF+++ Y+ V ED T
Sbjct: 3200 SYNISVRATD------QSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGT 3253
Query: 1091 SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQ 1150
VL V AT KD G + + Y LI ++GK F + TG I + + F
Sbjct: 3254 QVLAVFATSKDIGTNAEITY-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLV 3310
Query: 1151 VIATDDYGKGLSGKADVLVSVVNQLD 1176
V A D LS A V +++ + D
Sbjct: 3311 VEAKDGGTPALSAVATVNINLTDVND 3336
Score = 194 bits (492), Expect = 9e-49
Identities = 287/1139 (25%), Positives = 455/1139 (39%), Gaps = 184/1139 (16%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
L V + ++ P VP + + P TY +VT + +D
Sbjct: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TY---------------AVVT--VDDLDD 292
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
N + S SI+ G P D E + E D F ++L ++
Sbjct: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
Query: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
A +D G P A ++I + F Y I E +P G
Sbjct: 347 A-KDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
Query: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
Query: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
Query: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGK 603
ITY I F+IN+ TG+I+ +
Sbjct: 507 ITYSIASLNLLPFVINQFTGVISTT----------------------------------E 532
Query: 604 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
Query: 661 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 717
+ V A D D + GN F + + + K N +++ + L
Sbjct: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
Query: 718 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 739
+ ATDG +H + S+ + LA K+L
Sbjct: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
Query: 740 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 792
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
Query: 793 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 852
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
Query: 853 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 911
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
Query: 912 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 968
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
Query: 969 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1024
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Query: 1025 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1082
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
Query: 1083 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1142
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
Query: 1143 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1199
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
Score = 172 bits (437), Expect = 2e-42
Identities = 260/1106 (23%), Positives = 461/1106 (41%), Gaps = 181/1106 (16%)
Query: 87 MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPT 146
+D KQ F N T R D+ P+++ S+ + EV +V + N ++P
Sbjct: 998 LDYEKQQ-FYNLTVRAKDKGRPVSLSSVS--------------FVEVEVVDVNENLHTPY 1042
Query: 147 FKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI 206
F + +V E + +GT++ A D D G +G+I+Y I+ D + F I
Sbjct: 1043 FPDFAVVGSVKENSRIGTSVL-----QVTARDEDSGRDGEIQYSIR----DGSGLGRFSI 1093
Query: 207 PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFL 266
+G I L+ E Y++ + A DR +T + ++V D +D P+
Sbjct: 1094 DDE-SGVITAADILDRETMGSYWLTVYATDRGV---VPLYSTIEVYIEVEDVNDNAPL-- 1147
Query: 267 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 326
P+ Y + +P++++ I IQA D D S + Y I
Sbjct: 1148 ---------TSEPIYYPVVMEN--SPKDVSVI----QIQAEDPDS-----SSNEKLTYRI 1187
Query: 327 LVGTPEDYPRFFHMHPRTAELSLLEPVNR--DFHQKFDLVIKAEQDNGHPLPAFAGLHI- 383
G P++ FF ++ +T L+ +R D Q+ + ++ +G P P + + +
Sbjct: 1188 TSGNPQN---FFAINIKTG---LITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVV 1241
Query: 384 -EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPEL 441
++LDEN+ P F YQ + E D P+ R A D+D + + E+
Sbjct: 1242 VQVLDENDNKPQFPEKVYQIKLPER--------DRKKRGEPIYRAFAFDRD--EGPNAEI 1291
Query: 442 HLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV-----QESEPV 493
+ ND F +TG+ R++ ++ I V Q+S
Sbjct: 1292 SYSIVDGNDDGKFFIDPKTGMVS--------SRKQFTAGSYDILTIKAVDNGRPQKSSTA 1343
Query: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
++I+ + +P Y +T M D V ++ V + + +N + ++I+
Sbjct: 1344 RLHIEWIKKPPPSPIPLTFDEPFYNFTVME-SDRVTEIVGVVSVQPANTPLWFDIV---G 1399
Query: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRY 613
G+F D+A AE+ G + + K LD E Y
Sbjct: 1400 GNF------------------------------DSAFDAEKGVGTIVIAKPLDAEQRSIY 1429
Query: 614 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKAT 671
+ + +DG + V I V D NDN P F P + E+ + + Q++AT
Sbjct: 1430 NMSVEVTDGT--NVAVTQVFIKVLDNNDNGPEFSQ--PNYDVTISEDVLPDTEILQIEAT 1485
Query: 672 DPDAG--INGQVHYSLGNFN-NLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHP 727
D D ++ VH S+ + + FRI S G +YTA +L+ E +D + L ++ D
Sbjct: 1486 DRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPY 1545
Query: 728 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS--YRI 785
R + + + V D +D+SP FTN Y V E+ G+ +LQ+ A D D G N Y I
Sbjct: 1546 RRNLARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTI 1605
Query: 786 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTV 843
+ + F + P G +++ + PD F++ PP AT V +
Sbjct: 1606 EAGNTGNMFKIEPVLGIITICKE------PDMTTMGQFVLSIKVTDQGSPPMSATAIVRI 1659
Query: 844 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 903
V ++ P F + Y+ V + GT + + A + S + Y V D
Sbjct: 1660 SVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA-------ISQSTLIYEVKDGDI-- 1710
Query: 904 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 962
IF + SG + T+ L+ E T+ ++L++ A + M+S+ATV I ++ + P
Sbjct: 1711 -NGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAP 1767
Query: 963 RFTQEEYRPPPVSELATKGTMVGVISAAAI-----------NQSIVYSIVSGNEEDTFGI 1011
F +Y +SE A ++V + + + N +VY IV + F +
Sbjct: 1768 VFLFSQY-SGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTV 1826
Query: 1012 NNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070
++ TG I LD+ET + V DS L + + +V IE+ D N++P
Sbjct: 1827 DSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQL------TAESPVEVNIEVTDVNDNP 1880
Query: 1071 PVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK-EGFVVETY 1129
PVF + + + + VL+V ATD D+ + Y L+ EG + F++++
Sbjct: 1881 PVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLM-----EGSLDHFLIDSN 1935
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATD 1155
+G++ + +N+ + ++ V +D
Sbjct: 1936 SGVL--TIKNNNLSKDHYMLIVKVSD 1959
Score = 159 bits (401), Expect = 3e-38
Identities = 211/908 (23%), Positives = 384/908 (42%), Gaps = 139/908 (15%)
Query: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
Query: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
Query: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
Query: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYAL 581
P +V+ T D D+G+NGEI + I+ G D F + K + Y +
Sbjct: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWL-----------NEYKI 326
Query: 582 TVQAADNAPPAERSTGILTLGKALDRESTD-RYILIITASD-GRPDGTSTATVNIVVTDV 639
+ K +D ES Y L + A D G P S +
Sbjct: 327 KER------------------KQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPT 368
Query: 640 NDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNG 698
D P+ ++S+ E V + P+ I+ + S G F+I +G
Sbjct: 369 RDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPGEDAVYFKINPRSG 427
Query: 699 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 758
I TA LN ++ Y+L V +G + + + I + D +D++P F Y V
Sbjct: 428 LIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHTPEFQQPLYDAYVN 482
Query: 759 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 816
E++P GT++L + A D D G N ++Y I S + F ++ FTG +S LD+E+ P+
Sbjct: 483 ESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVISTTEELDFESSPE 541
Query: 817 QEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 874
F+V A D +G+ VT+ + ++ND P+F K +G+++ D G I
Sbjct: 542 ---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHI 597
Query: 875 TTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-------SGRVITRV 921
T V A D D L V+Y++ +++ F Y + + ++++ +G R+
Sbjct: 598 TAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRI 653
Query: 922 NLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV---------LHPGEI 961
+ +P +I K+ +F E ++ K+L+ L G +
Sbjct: 654 TATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFL 713
Query: 962 ---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDT 1008
P F + V E G + I A + N ++++I GN +
Sbjct: 714 DFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSC 773
Query: 1009 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1068
F I+ TG + V P+D E Y+ L + + +L P KS+ + I ++D N+
Sbjct: 774 FNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSSWRLLTINVEDAND 826
Query: 1069 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1128
+ PVF + Y + E + + T +++V+A DKD G+ + Y ++ + F + +
Sbjct: 827 NSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-----TDTQQFAINS 881
Query: 1129 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTL 1188
TG++ A ++ + ++ A D G + V + V + +P +
Sbjct: 882 STGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSY 941
Query: 1189 VEKKIEDL 1196
K +EDL
Sbjct: 942 SVKVLEDL 949
Score = 153 bits (386), Expect = 2e-36
Identities = 231/990 (23%), Positives = 401/990 (40%), Gaps = 149/990 (15%)
Query: 212 GNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLV 271
G IV+ K L+ E ++ Y + ++ D T + + VLD +D GP F
Sbjct: 1413 GTIVIAKPLDAEQRSIYNMSVEVTDGTN------VAVTQVFIKVLDNNDNGPEFSQ---- 1462
Query: 272 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 331
PN Y I E ++ P I+A D+D ++ + Y++
Sbjct: 1463 PN--------YDVTISE-----DVLPDTEILQIEATDRD-------EKHKLSYTVHSSID 1502
Query: 332 EDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQ 391
R F + P T L E ++ + K L I A + + + D N+
Sbjct: 1503 SISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDH 1562
Query: 392 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
SPYFT P Y+ + ESA +G+ + L++ ALDKD + + + + ++
Sbjct: 1563 SPYFTNPLYEASVFESAALGSAV---------LQVTALDKDKGENAELIYTIEAGNTGNM 1613
Query: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTP 507
F + + +T+ + D + SI D Q S P+ IV I V ++++ P
Sbjct: 1614 FKIEP--VLGIITICKEPDMTTMGQFVLSIKVTD--QGSPPMSATAIVRISVTMSDNSHP 1669
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLIT 566
F Y V ++ G SVI ++A+ S + YE+ G G F IN +G+IT
Sbjct: 1670 KFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLIYEVKDGDINGIFTINPYSGVIT 1724
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
++ +Y L +QA + A A
Sbjct: 1725 TQKALDYERTSSYQLIIQATNMAGMA---------------------------------- 1750
Query: 627 TSTATVNIVVTDVNDNAPVF---------DPYLPRNLSVVEEEANAFVGQVKATDPDAGI 677
S ATVNI + D NDNAPVF P N V + + V ++ATD D+
Sbjct: 1751 -SNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLV--IRATDADSNR 1807
Query: 678 NGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH--PRHSTL 732
N + Y + F + +S G+I T L+ E ++ V D S +
Sbjct: 1808 NALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
Query: 733 TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD--LGANVSYRIRSPEV 790
+ I+V D++DN PVFT + + ++ G +L++ A D D + ++Y + +
Sbjct: 1868 EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL 1927
Query: 791 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 850
HF + +G L++ + + V Y T + VT++VK+ D
Sbjct: 1928 DHFL-IDSNSGVLTIKNN----NLSKDHYMLIVKVSDGKFYST-----SMVTIMVKEAMD 1977
Query: 851 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 910
F++ Y ++ + T IT V +A L ++Y + + P + F++
Sbjct: 1978 SGLHFTQSFYSTSISEN---NTNITKVAIVNAVGNRL-NEPLKYSILN-----PGNKFKI 2028
Query: 911 EEDSGRV-ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE 968
+ SG + T V + E +++LVV A + + + + V++ + + P F
Sbjct: 2029 KSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLP 2088
Query: 969 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1024
Y V A GT++ ++A N + Y V ++ F IN +G + +
Sbjct: 2089 YY-AAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYGHFEINPNSGNVILK--- 2142
Query: 1025 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1084
E S + ++ + ++ + PS S + ++ I I N PVF K FY V+E
Sbjct: 2143 --EAFNSDLSNIEY-GVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTASVNE 2197
Query: 1085 DARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRR 1144
D RM T +L + AT + ++ + P K+ F ++ TG++K
Sbjct: 2198 DIRMNTPILSINATSPE--GQGIIYIIIDGDPFKQ----FNIDFDTGVLKVVSPLDYEVT 2251
Query: 1145 SYFKFQVIATDDY-GKGLSGKADVLVSVVN 1173
S +K + A+D G D+LV+ VN
Sbjct: 2252 SAYKLTIRASDALTGARAEVTVDLLVNDVN 2281
Score = 136 bits (343), Expect = 2e-31
Identities = 236/1046 (22%), Positives = 411/1046 (39%), Gaps = 209/1046 (19%)
Query: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
Query: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
TY I E TP + VT A D D G Y + F
Sbjct: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
Query: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
Query: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
Query: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
Query: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILII 617
IN +GLI A + + Y L V
Sbjct: 422 INPRSGLIVTARPLNTVKKEVYKLEVT--------------------------------- 448
Query: 618 TASDGRPDGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATD 672
+G A V I + D ND+ P++D Y+ ++ V V V A+D
Sbjct: 449 -----NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASD 498
Query: 673 PDAGINGQVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPR 728
D G NG + YS+ + N L + + G I T +L+ E + Y +V A+D G+ +
Sbjct: 499 KDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRH 558
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 788
S + + I++ +++DNSP+F ++ + P G I + A D+D V Y+I S
Sbjct: 559 ESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISG 618
Query: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---- 844
FF L+P +G L L +SL + + + A D P ++V+
Sbjct: 619 NELGFFYLNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKV 676
Query: 845 --------------------------------------VKDMNDYPPVFSKRIYKGM-VA 865
+N P F K + V
Sbjct: 677 SSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVK 736
Query: 866 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 925
D G I + A DAD +V + + D S F ++ ++G++ + ++
Sbjct: 737 EDLPVGANILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDR 791
Query: 926 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMV 984
E T ++ L + +D G P SS + I V + P F Q+ Y V+ L + G
Sbjct: 792 EHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGT 848
Query: 985 GVISAAA------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
+I A N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A
Sbjct: 849 EIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEA 906
Query: 1039 -DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
D E V T KV+++ D N+ P F Y V ED + T + ++
Sbjct: 907 RDKAESGQQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLET 960
Query: 1098 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1157
D D G + Y L + + F ++ +G I+ + ++ ++ V A D
Sbjct: 961 HDPDLGLGGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD-- 1014
Query: 1158 GKGLSGKADVLVSVVNQLDMQVIVSN 1183
KG V +S V+ ++++V+ N
Sbjct: 1015 -KG----RPVSLSSVSFVEVEVVDVN 1035
Score = 129 bits (323), Expect = 4e-29
Identities = 128/512 (25%), Positives = 224/512 (43%), Gaps = 64/512 (12%)
Query: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
Query: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
Query: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
Query: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
Query: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
Query: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
Query: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
G ++ IL G + + + G++ A + Y L VQA D+ P + S +
Sbjct: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTYIR 3538
Query: 601 LGKALDRESTDR------YILIITASDGRPDG 626
+ + EST + I I+T D P G
Sbjct: 3539 V--RVIEESTHKPTAIPLEIFIVTMEDDFPGG 3568
Score = 97.4 bits (241), Expect = 1e-19
Identities = 112/458 (24%), Positives = 190/458 (41%), Gaps = 58/458 (12%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V D NDN P F+ Y TV E T GT + F AT D G N +I Y+I+
Sbjct: 3222 VTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF-----ATSKDIGTNAEITYLIR 3276
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ F+I TG I + + L+YE R++++++A D + T+
Sbjct: 3277 SGNEQ----GKFKINPK-TGGISVSEVLDYELCKRFYLVVEAKDGG---TPALSAVATVN 3328
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+++ D +D P F V Y A I E + ++ I I +D +
Sbjct: 3329 INLTDVNDNPPKFSQDV------------YSAVISE-------DALVGDSVILLIAEDVD 3369
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
QP I +SI+ G D F + P + + + ++R+ + L+++A
Sbjct: 3370 SQPNGQ---IHFSIVNG---DRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGI 3423
Query: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
+ + A ++I+I D N+ SP FT +Y I E+ PVG TS L++V D+D
Sbjct: 3424 PAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVG---------TSILQLVVTDRD 3474
Query: 433 IEDTKDP-ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQE 489
P + + F + GI R + Q + E Y + A D Q+
Sbjct: 3475 SFHNGPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLE---YVLCVQAKDSGKPQQ 3531
Query: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
+ ++V++ + + PT + + D PG + ++ A D D +T+ +
Sbjct: 3532 VSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQD--MYDVLTFALK 3589
Query: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
+ F +N G I G++ Y L V +D
Sbjct: 3590 SEQKSLFKVNSHDGKIIALGGLD---SGKYVLNVSVSD 3624
Score = 52.0 bits (123), Expect = 5e-06
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 987 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVL--RVQADSLEVV 1044
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
Query: 1045 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1104
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
Query: 1105 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1159
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Query: 1160 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1198
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 268 bits (684), Expect = 5e-71
Identities = 312/1158 (26%), Positives = 491/1158 (42%), Gaps = 152/1158 (13%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V + D +D P F R Y+ I T ++ + D
Sbjct: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
Query: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
Query: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
Query: 548 ILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
+ + VE+I ++A+ ++ TG +T K LD
Sbjct: 2848 L-----------------DQSQSVEVI--ESFAINME-----------TGWITTLKELDH 2877
Query: 608 ESTDRYILIITASDG--RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 665
E D Y + + ASD + +STA V++ VTDVND+ P F + + ++ +
Sbjct: 2878 EKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVI 2937
Query: 666 GQVKATDPDAG-INGQVHY------SLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVV 718
+ TD D+ IN QV Y LG F + I + +Y L+RE RD Y L +
Sbjct: 2938 AILSTTDADSEEINRQVTYFITGGDPLGQFA-VETIQNEWKVYVKKPLDREKRDNYLLTI 2996
Query: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 778
ATDG S + +KVLD +DNSPV + Y+ + E++ G I+QI A D D+
Sbjct: 2997 TATDGTFS---SKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIR 3053
Query: 779 AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
+N ++Y + + F L+P TGEL LD E ++A LV A D G
Sbjct: 3054 SNAEITYTLLGSGAEKF-KLNPDTGELKTSTPLDRE----EQAVYHLLVRATDGGGRFCQ 3108
Query: 837 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 896
A++ + ++D+ND P FS Y V + GT +T V A DAD GL + +
Sbjct: 3109 --ASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADA-GLNRKILYSLI 3165
Query: 897 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV 955
D F + E SG + L+ E ++ L + A D G P ++++ TV + V
Sbjct: 3166 DSAD-----GQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVSV 3220
Query: 956 LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA----INQSIVYSIVSGNEEDTFGI 1011
L + P + VSE GT V + AA+ N I YSI+SGNE F I
Sbjct: 3221 LDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSI 3280
Query: 1012 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1071
++ TG +++ LDYE+ Y L V+A + PS S+ A V + + D N++ P
Sbjct: 3281 DSKTGAVFIIENLDYESSHEYYLTVEA-------TDGGTPSLSDVATVNVNVTDINDNTP 3333
Query: 1072 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETY 1129
VF + Y +SEDA + SV+ V A D D + S + Y +I +G +G F ++
Sbjct: 3334 VFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSII-----DGNQGSSFTIDPV 3388
Query: 1130 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
G +K L S + V A+D+ V + V + D + S +++
Sbjct: 3389 RGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVI 3448
Query: 1190 EKKIEDLTEILDRYVQEQIPGA----KVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ 1245
+QE P ++VV + +G F T D + ++PQ
Sbjct: 3449 --------------IQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNPQ 3494
Query: 1246 ----TNRAIDRNELFKFL 1259
T+ AI R E +L
Sbjct: 3495 GVLLTSSAIKRKEKDHYL 3512
Score = 258 bits (659), Expect = 4e-68
Identities = 272/993 (27%), Positives = 443/993 (44%), Gaps = 136/993 (13%)
Query: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
P F Y TV+E P+GT I + +G + +++ N + +++F
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV---------LYSLVKGNTPESNRDESF 2751
Query: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
I +G + L K L++E Y I A R + + +++ V D +D P+
Sbjct: 2752 VIDRQ-SGRLKLEKSLDHETTKWYQFSILA--RCTQDDHEMVASVDVSIQVKDANDNSPV 2808
Query: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
F Y+A I E P I I+A D D ++Y
Sbjct: 2809 F------------ESSPYEAFIVE-NLPGGSRVI----QIRASDADSGTNGQ-----VMY 2846
Query: 325 SILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLH 382
S+ + F ++ T ++ L+ ++ + + + + A D+G L + A +
Sbjct: 2847 SLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVAS-DHGEKIQLSSTAIVD 2905
Query: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
+ + D N+ P FT Y+G + E P G I+ + D D E+ +
Sbjct: 2906 VTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAI---------LSTTDADSEEINRQVTY 2956
Query: 443 LFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 501
D F V + + +P+DRE++ Y +ITA DG S+ IV ++V+D
Sbjct: 2957 FITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSSK-AIVEVKVLD 3015
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
ANDN+P + Y + D+ PG ++Q++A DAD SN EITY +L F +N
Sbjct: 3016 ANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPD 3075
Query: 562 TG-LITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITAS 620
TG L T P LDRE Y L++ A+
Sbjct: 3076 TGELKTSTP-----------------------------------LDREEQAVYHLLVRAT 3100
Query: 621 DGRPDGTSTATVNIVVT--DVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDA 675
DG G +IV+T DVNDNAP F DPY ++V E E + +V+ATD DA
Sbjct: 3101 DG---GGRFCQASIVLTLEDVNDNAPEFSADPYA---ITVFENTEPGTLLTRVQATDADA 3154
Query: 676 GINGQVHYSL-GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR-HSTL 732
G+N ++ YSL + + F I +G I L+RE++ Y L + A D + R +T
Sbjct: 3155 GLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATG 3214
Query: 733 TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA--KDVDLGANVSYRIRSPEV 790
T+ + VLDI+DN PVF Y V E++ GT +LQ+ A +D++ A ++Y I S
Sbjct: 3215 TVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE 3274
Query: 791 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 850
F++ TG + ++ +LDYE+ E +T VEA D +ATV V V D+ND
Sbjct: 3275 HGKFSIDSKTGAVFIIENLDYES--SHEYYLT--VEATDGGTPSLSDVATVNVNVTDIND 3330
Query: 851 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 910
PVFS+ Y +++ DAV + TV A+DAD P S + Y + D S F +
Sbjct: 3331 NTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPS--NSHIHYSIIDGN---QGSSFTI 3385
Query: 911 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 969
+ G V L+ E + + L V A D+G P ++ TV I V + P F++ Y
Sbjct: 3386 DPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNY 3445
Query: 970 RPPPVSELATKGTMVG--VISAAAINQS-------IVYSIVSGNEEDTFGINNITGVIYV 1020
S + + VG V+ ++ ++IV+GN+E F +N GV+
Sbjct: 3446 -----SVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFEVNP-QGVLLT 3499
Query: 1021 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP-VFQKKFYI 1079
+ + + + Y+L+V+ +A+ P S+ + I + +E+ +PP + + +I
Sbjct: 3500 SSAIKRKEKDHYLLQVK-------VADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFI 3552
Query: 1080 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112
E+ + ++ ATD+D Y + Y L
Sbjct: 3553 TSSGEEYSGGV-IGKIHATDQDV--YDTLTYSL 3582
Score = 255 bits (652), Expect = 2e-67
Identities = 232/824 (28%), Positives = 370/824 (44%), Gaps = 96/824 (11%)
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA-FAGLHIEILDENNQSPYFT 396
F + T L +L P++R+ K+ L I D G P A + LH+ ++D N+ P F
Sbjct: 765 FMIDMETGMLKILSPLDRETTDKYTLNITV-YDLGIPQKAAWRLLHVVVVDANDNPPEFL 823
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
SY + E V + I +++ A DKD+ P H+ + T T +
Sbjct: 824 QESYFVEVSEDKEVHSEI---------IQVEATDKDL----GPNGHVTYSIVTDTDTFSI 870
Query: 457 TGITRYLTLLQPVDREEQQTYTFSITAFDGVQES----EPVIVNIQVMDANDNTPTFPEI 512
+T + + +P+DRE Q ++ I A D +E V+V + + D NDN PTF
Sbjct: 871 DSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPP 930
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572
+Y V V D+ G ++ L A D D G +G++ Y +L +G+F ++K +G + I ++
Sbjct: 931 NYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLD 990
Query: 573 MIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV 632
+ Y LTV+A D P S ST V
Sbjct: 991 FEKKQVYNLTVRAKDKGKPVSLS--------------------------------STCYV 1018
Query: 633 NIVVTDVNDNA--PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNF 688
+ V DVN+N PVF ++ + + + V V A D DA +G++ YS+ G+
Sbjct: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSG 1078
Query: 689 NNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747
+F+I G I T+ +L+RE +Y L V ATD V P S + + I+V D++DN+P
Sbjct: 1079 VGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQ 1138
Query: 748 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 805
+ Y + EN P +++QIEA D D +N + Y+I S + FF++HP TG ++
Sbjct: 1139 TSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITT 1198
Query: 806 L-RSLDYEAFPDQEASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGM 863
R LD E + +T G+ P IA V V + D ND P F ++ YK
Sbjct: 1199 TSRKLDREQQDEHILEVTVTDN-----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIR 1253
Query: 864 V----APDAVKGT---PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 916
+ PD + P+ V A D D P + + Y ++D F +E +G
Sbjct: 1254 LPEREKPDRERNARREPLYHVIATDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGV 1308
Query: 917 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPP 973
V ++ I L + A D+G P SS+ + I + P P +E +
Sbjct: 1309 VSSKRFSAAGEYDI--LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFT 1366
Query: 974 VSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYV 1033
V E M+GVIS + + I GN + F ++ TG I V PLD E +++Y
Sbjct: 1367 VMESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYN 1426
Query: 1034 LRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1092
L V+A D +L +V+I++ D N+H P F Y + ED T +
Sbjct: 1427 LTVEATDGTTTIL-----------TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEI 1475
Query: 1093 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA 1136
L++ A D+D N + + P+ K F ++ TG + T+
Sbjct: 1476 LQISAVDQDEKNKLIYTLQSSRDPLSLKK--FRLDPATGSLYTS 1517
Score = 243 bits (621), Expect = 1e-63
Identities = 295/1198 (24%), Positives = 496/1198 (41%), Gaps = 159/1198 (13%)
Query: 88 DPVKQMLFLNSTGRVLDRDPPMNIHS---IVVQVQCINKKVGTIIYHEVRIVVRDRNDNS 144
DP Q +TG V++ P++ + + ++ + G V I+V D NDN
Sbjct: 2222 DPFSQFTINFNTG-VINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNP 2280
Query: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
P F +SY T++E + +GT++ ATD D PN I Y Q + S+D F
Sbjct: 2281 PVFAQQSYAVTLSEASVIGTSVV-----QVRATDSDSEPNRGISY--QMFGNHSKSHDHF 2333
Query: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
+ TG I L + L+YE ++ + ++A D ++ +TVDV D +D P+
Sbjct: 2334 HVDSS-TGLISLLRTLDYEQSRQHTIFVRAVDGGM---PTLSSDVIVTVDVTDLNDNPPL 2389
Query: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
F + I E R E ++A D D SD + Y
Sbjct: 2390 F-----------------EQQIYEARISEHAPHGHFVTCVKAYDADS-----SDIDKLQY 2427
Query: 325 SILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIE 384
SIL G + F + T ++L + L + + +H+
Sbjct: 2428 SILSGNDHKH---FVIDSATGIITLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVT 2481
Query: 385 ILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
++ N SP F Y+ + E+AP+ + + + D D H+
Sbjct: 2482 VIGGNLHSPAFLQNEYEVELAENAPLHTLV---------MEVKTTDGDSGIYGHVTYHI- 2531
Query: 445 LNDYTSV-FTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQESEPVIVNIQVMD 501
+ND+ F + + G + L+ +DRE ++ + + A D + VN+ + D
Sbjct: 2532 VNDFAKDRFYINERG---QIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTD 2588
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG---DFII 558
NDN P F Y+V + + G SV+++ A DADEGSN +ITY I ++ + I
Sbjct: 2589 DNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEI 2648
Query: 559 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRE----STDRYI 614
NK +G+IT + + + V+A DN P++ S +L K L E
Sbjct: 2649 NKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESV-VLVYVKILPPEMQLPKFSEPF 2707
Query: 615 LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 674
T S+ P GT +L E VK P+
Sbjct: 2708 YTFTVSEDVPIGTEI-----------------------DLIRAEHSGTVLYSLVKGNTPE 2744
Query: 675 AGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA-TDGAVHPRHSTL 732
+ N + F I +G + L+ E +Y+ ++A H +++
Sbjct: 2745 S-----------NRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASV 2793
Query: 733 TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI---RS 787
++I+V D +DNSPVF +S Y + ENLP G+ ++QI A D D G N V Y + +S
Sbjct: 2794 DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQS 2853
Query: 788 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 847
EV FA++ TG ++ L+ LD+E + + + I A V V V D
Sbjct: 2854 VEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKI---QLSSTAIVDVTVTD 2910
Query: 848 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 907
+ND PP F+ IYKG V+ D +G I + DAD + +V Y + P
Sbjct: 2911 VNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEI-NRQVTYFITGGD---PLGQ 2966
Query: 908 FEVE--EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFT 965
F VE ++ +V + L+ E + L + A D SS A V++ VL +
Sbjct: 2967 FAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG---TFSSKAIVEVKVLDANDNSPVC 3023
Query: 966 QEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVN 1021
++ + E G ++ ISA N I Y+++ G+ + F +N TG + +
Sbjct: 3024 EKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTS 3082
Query: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1081
PLD E + Y L V+A + A + + ++D N++ P F Y
Sbjct: 3083 TPLDREEQAVYHLLVRATD---------GGGRFCQASIVLTLEDVNDNAPEFSADPYAIT 3133
Query: 1082 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFH 1140
V E+ T + RV+ATD D G + Y LI + +G F + +G+I+
Sbjct: 3134 VFENTEPGTLLTRVQATDADAGLNRKILYSLI-----DSADGQFSINELSGIIQLEKPLD 3188
Query: 1141 NMRRSYFKFQVIATDD-YGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI-----E 1194
++ + + A D + L+ V+VSV++ +++ PP ++ E
Sbjct: 3189 RELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLD-------INDNPPVFEYREYGATVSE 3241
Query: 1195 DL---TEILDRYV--QEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTN 1247
D+ TE+L Y ++ A++ I HG FS++ T + +D +++
Sbjct: 3242 DILVGTEVLQVYAASRDIEANAEITYSIISGNEHG-KFSIDSKTGAVFIIENLDYESS 3298
Score = 215 bits (548), Expect = 3e-55
Identities = 277/1115 (24%), Positives = 453/1115 (40%), Gaps = 162/1115 (14%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
Query: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
Query: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
A+P P E I V P+ + + + + YSI G
Sbjct: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
Query: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
Query: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD 621
TG+IT++ + Y+L + +D + R ST ++ +I +
Sbjct: 2444 TGIITLSNLHRHALKPFYSLNLSVSD----------------GVFRSSTQVHVTVIGGNL 2487
Query: 622 GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV 681
P N ++ +NAP+ + V +VK TD D+GI G V
Sbjct: 2488 HSP----AFLQNEYEVELAENAPL----------------HTLVMEVKTTDGDSGIYGHV 2527
Query: 682 HYSLGN--FNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 739
Y + N + F I G I+T KL+RE + V + + T+ + +
Sbjct: 2528 TYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILT 2587
Query: 740 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR--SPEVKHFFA 795
D +DN+P F + Y V + + GT+++++ A D D G+N ++Y I S VK
Sbjct: 2588 DDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLE 2647
Query: 796 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF 855
++ +G ++ SL + TF V A D + V V + P F
Sbjct: 2648 INKLSGVITTKESL----IGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKF 2703
Query: 856 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP--ASIFEVEED 913
S+ Y V+ D GT I + AE + V Y + P F ++
Sbjct: 2704 SEPFYTFTVSEDVPIGTEIDLIRAEH-------SGTVLYSLVKGNTPESNRDESFVIDRQ 2756
Query: 914 SGRVITRVNLNEEPTTIFKLVVVA---FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYR 970
SGR+ +L+ E T ++ ++A DD E V S ++++ + P F Y
Sbjct: 2757 SGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNS-PVFESSPYE 2815
Query: 971 PPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEE---DTFGINNITGVIYVNGPL 1024
V L ++ + ++ A N ++YS+ ++F IN TG I L
Sbjct: 2816 AFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKEL 2875
Query: 1025 DYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVS 1083
D+E R +Y ++V A D E + S+TA V + + D N+ PP F + Y G VS
Sbjct: 2876 DHEKRDNYQIKVVASDHGEKI-------QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVS 2928
Query: 1084 EDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML--FHN 1141
ED + + TD D+ + I G+ F VET K +
Sbjct: 2929 EDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQ--FAVETIQNEWKVYVKKPLDR 2986
Query: 1142 MRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+R + + ATD S KA V V V++ D
Sbjct: 2987 EKRDNYLLTITATDG---TFSSKAIVEVKVLDAND 3018
Score = 214 bits (545), Expect = 6e-55
Identities = 278/1074 (25%), Positives = 451/1074 (41%), Gaps = 151/1074 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSIV 862
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 863 ------TDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDLG 957
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ YS+L + F + + + +++ ++ + Q ++L ++A+ D G
Sbjct: 958 -----QSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAK-DKG 1007
Query: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
Query: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
Query: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKAL 605
+I G QG F I+ TGLIT T + L
Sbjct: 1177 KITSGNPQGFFSIHPKTGLIT---------------------------------TTSRKL 1203
Query: 606 DRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEE 659
DRE D +IL +T +D G P ++ A V + + D NDN P F LP +
Sbjct: 1204 DREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDR 1262
Query: 660 EANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYY 714
E NA + V ATD D G N ++ YS+ GN + F I + ++ + + +Y
Sbjct: 1263 ERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYD 1321
Query: 715 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIE 771
L + A D + ST L I+ + S P+ F S +T V E+ P I I
Sbjct: 1322 ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
Query: 772 AKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY 831
+ G + + I F + TG + + + LD E Q+++ VEA D
Sbjct: 1382 VEPP--GIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGT 1435
Query: 832 GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASR 891
T+ + V + V D ND+ P FS Y+ ++ D T I + A D D ++
Sbjct: 1436 TTI---LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNK 1488
Query: 892 VRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATV 951
+ Y + + P F ++ +G + T L+ E L V+ D PV + A +
Sbjct: 1489 LIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARI 1548
Query: 952 KILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEE 1006
+ V + P FT Y+ V E A G++V ++A N ++YSI SGN
Sbjct: 1549 VVNVSDTNDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIG 1607
Query: 1007 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
++F I+ + G I LD + Y L V+A + P S V I +
Sbjct: 1608 NSFMIDPVLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIA 1660
Query: 1067 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--F 1124
+N P F K Y +SE + + V V A + + ++ IK+G G F
Sbjct: 1661 DNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAF 1710
Query: 1125 VVETYTGLIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+ ++G I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1711 DINPHSGTIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
Score = 210 bits (535), Expect = 9e-54
Identities = 235/876 (26%), Positives = 398/876 (45%), Gaps = 83/876 (9%)
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
Query: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
Query: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
Query: 573 MIVGRT---YALTVQAADN---APPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
+G ++L + A D A P + + K ++ + + + + A
Sbjct: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
Query: 627 T--STATVNIVVTD---VNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQ 680
+ V + D VN + P F LP + V E + + V + +TD D G NG+
Sbjct: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
Query: 681 VHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 737
+ Y++ GN ++ F I G + L+RE D Y L + D + + + L +
Sbjct: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
Query: 738 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 795
V+D +DN P F +Y V V E+ + I+Q+EA D DLG N V+Y I + F+
Sbjct: 812 VVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFS 869
Query: 796 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPP 853
+ TG +++ R LD E E S+ +EA D P +TV V V +D+ND PP
Sbjct: 870 IDSVTGVVNIARPLDREL--QHEHSLK--IEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
Query: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 913
F Y+ V D +GT I ++ E DP + +VRY + D + F+V++
Sbjct: 926 TFIPPNYRVKVREDLPEGTVI--MWLEAHDPDLGQSGQVRYSLLD----HGEGNFDVDKL 979
Query: 914 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILV------LHPGEIPRFTQ 966
SG V L+ E ++ L V A D G+PV +SS+ V++ V LHP F +
Sbjct: 980 SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
Query: 967 EEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1022
+ V E A G++V +SA A + I YSI G+ F I TGVI +
Sbjct: 1040 K----GTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSD 1095
Query: 1023 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1082
LD E+ + Y L V A VV S+ ++YIE++D N++ P + Y +
Sbjct: 1096 RLDRESTSHYWLTVFATDQGVV-------PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEI 1148
Query: 1083 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFH 1140
E++ SV++++A D D+ + + Y++ +GF + TGLI T+
Sbjct: 1149 MENSPKDVSVVQIEAFDPDSSSNDKLMYKI----TSGNPQGFFSIHPKTGLITTTSRKLD 1204
Query: 1141 NMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
++ +V TD+ S A V+V ++++ D
Sbjct: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDEND 1240
Score = 209 bits (532), Expect = 2e-53
Identities = 201/671 (29%), Positives = 312/671 (46%), Gaps = 98/671 (14%)
Query: 495 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 554
VN + PT + V + G SVI + + D D G NG++ Y + G +
Sbjct: 709 VNAHIPQFRSTLPT------GIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNE- 761
Query: 555 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYI 614
D+ + TG+L + LDRE+TD+Y
Sbjct: 762 --------------------------------DSCFMIDMETGMLKILSPLDRETTDKYT 789
Query: 615 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKA 670
L IT D G P + +++VV D NDN P F + Y + V E+ E ++ + QV+A
Sbjct: 790 LNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEA 846
Query: 671 TDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR 728
TD D G NG V YS+ + F I S G + A L+RE++ + L + A D A P+
Sbjct: 847 TDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQ 906
Query: 729 -HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 787
ST+ + + + D++DN P F Y V V E+LP GT I+ +EA D DLG S ++R
Sbjct: 907 LFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRY 964
Query: 788 PEVKH---FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---V 841
+ H F + +G + +++ LD+E ++ V A D P +++ V
Sbjct: 965 SLLDHGEGNFDVDKLSGAVRIVQQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYV 1018
Query: 842 TVIVKDMND--YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 899
V V D+N+ +PPVFS + KG V DA G+ + TV A D D +RY + D
Sbjct: 1019 EVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDG 1076
Query: 900 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG 959
+F++ E++G + T L+ E T+ + L V A D G +SS + I V
Sbjct: 1077 S---GVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVN 1133
Query: 960 EIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNIT 1015
+ T E P + E + K V I A ++ N ++Y I SGN + F I+ T
Sbjct: 1134 DNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKT 1193
Query: 1016 GVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1074
G+I LD E + ++ LEV + + P KS A+V ++I DEN++ P F
Sbjct: 1194 GLITTTSRKLDREQQDEHI-------LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFL 1246
Query: 1075 KKFYIGGVSE--------DARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GF 1124
+KFY + E +AR + V ATDKD G + ++Y I++G E F
Sbjct: 1247 QKFYKIRLPEREKPDRERNARR-EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKF 1300
Query: 1125 VVETYTGLIKT 1135
+E TG++ +
Sbjct: 1301 FIEPKTGVVSS 1311
Score = 206 bits (524), Expect = 2e-52
Identities = 276/1137 (24%), Positives = 471/1137 (41%), Gaps = 179/1137 (15%)
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
Query: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
Query: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
Query: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
Query: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVI-- 1091
Query: 568 APGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDG 626
+ +D LDREST Y L + A+D G
Sbjct: 1092 ----------------ETSDR----------------LDRESTSHYWLTVFATDQGVVPL 1119
Query: 627 TSTATVNIVVTDVNDNA-----PVFDPYL----PRNLSVVEEEANAFVGQVKATDPDAGI 677
+S + I V DVNDNA PV+ P + P+++SVV Q++A DPD+
Sbjct: 1120 SSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV---------QIEAFDPDSSS 1170
Query: 678 NGQVHYSL--GNFNNLFRITSNGSIYTAV--KLNREVRDYYELVVVATDGAVHPRHSTLT 733
N ++ Y + GN F I + T KL+RE +D + L V TD P+ +
Sbjct: 1171 NDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Query: 734 LAIKVLDIDDNSPVFTNSTYTV-LVEENLP------AGTTILQIEAKDVDLGAN--VSYR 784
+ +K+LD +DN P F Y + L E P + + A D D G N +SY
Sbjct: 1231 VIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYS 1290
Query: 785 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 844
I F + P TG +S R + A + + ++A D P +T +
Sbjct: 1291 IEDGNEHGKFFIEPKTGVVSSKR---FSAAGEYD---ILSIKAVD--NGRPQKSSTTRLH 1342
Query: 845 VKDMNDYPPVFSKRIY-KGMVAPDAVKGTPIT-TVYAEDADPPGLPASRVRYRVDDVQFP 902
++ ++ P + + ++ P+ + +PPG+P D+
Sbjct: 1343 IEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL------WFDITGG 1396
Query: 903 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP 962
S F+V++ +G +I L+ E + + L V A DG + + +K++ + P
Sbjct: 1397 NYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEA-TDGTTTILTQVFIKVIDTNDHR-P 1454
Query: 963 RFTQEEYRPPPVSELATKGTMVGVISAAAINQ----SIVYSIVSGNEE---DTFGINNIT 1015
+F+ +Y + A + ++ +A++Q ++Y++ S + F ++ T
Sbjct: 1455 QFSTSKYEVVIPEDTAPE---TEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPAT 1511
Query: 1016 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK 1075
G +Y + LD+E V +L V++ + VP K N A++ + + D N+H P F
Sbjct: 1512 GSLYTSEKLDHEA-------VHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTA 1564
Query: 1076 KFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLI 1133
Y G V E A + + VL+V A DKD G + + Y I+ G G F+++ G I
Sbjct: 1565 SSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLY-----SIESGNIGNSFMIDPVLGSI 1619
Query: 1134 KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEK-- 1191
KTA ++ + V ATD +S V + V I N P K
Sbjct: 1620 KTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFV-------TIADNASPKFTSKEY 1672
Query: 1192 --KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQT 1246
++ + I VV I GDAF + ++ +T A+D +T
Sbjct: 1673 SVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFET 1729
Score = 199 bits (506), Expect = 2e-50
Identities = 256/1101 (23%), Positives = 458/1101 (41%), Gaps = 149/1101 (13%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
Query: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
Query: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
Query: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE
Sbjct: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE------ 1485
Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKA 604
K + T+ + + + + L + +TG L +
Sbjct: 1486 ---------------KNKLIYTLQSSRDPLSLKKFRL-----------DPATGSLYTSEK 1519
Query: 605 LDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 663
LD E+ ++ L + D P + A + + V+D ND+AP F + +
Sbjct: 1520 LDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGS 1579
Query: 664 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVA 720
V QV A D D G N +V YS+ GN N F I GSI TA +L+R + Y+L+V A
Sbjct: 1580 VVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKA 1639
Query: 721 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 780
TD P ++ I V D+ SP FT+ Y+V + E + G+ + + A ++
Sbjct: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSS 1696
Query: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 840
V Y I+ F ++P +G + ++LD+E P + I GT G++T
Sbjct: 1697 VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLP---------IYTLIIQGTNMAGLST 1747
Query: 841 VTVI---VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT-------VYAEDADPPGLPAS 890
T + ++D ND PVF + Y G+++ A + + T + A DAD A
Sbjct: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDS-NAL 1806
Query: 891 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--S 948
V + V+ P + F ++ +G + T ++L+ E T+IF V D G P + + +
Sbjct: 1807 LVYHIVE----PSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYA 1862
Query: 949 ATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGN 1004
A V + V+ + P + + KG V ++A + S ++YSI GN
Sbjct: 1863 ANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGN 1922
Query: 1005 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1064
+ F ++ TG + V + R+ Y L V+A + V I ++
Sbjct: 1923 IGEKFSMDYKTGALTVQNTT--QLRSRYELTVRASDGRF----------AGLTSVKINVK 1970
Query: 1065 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1124
+ F + Y V E++ ++ + A + Y ++ P + F
Sbjct: 1971 ESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN--EPLFYHILNPDRR-----F 2023
Query: 1125 VVETYTGLIK-TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
+ +G++ T F ++ F V T+++ V V V +Q D + N
Sbjct: 2024 KISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVN 2083
Query: 1184 VPPTLVEKKIEDLTEILDRYV 1204
+P V K ++ ++ RYV
Sbjct: 2084 LPYYAVVKVDTEVGHVI-RYV 2103
Score = 199 bits (505), Expect = 3e-50
Identities = 258/1042 (24%), Positives = 428/1042 (41%), Gaps = 181/1042 (17%)
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
Query: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
Query: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
Query: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
K L I A P + + + ++L
Sbjct: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
Query: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
Query: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
Query: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
Query: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRY 613
F I+ TG++ IA ++ + ++L ++A D A RE
Sbjct: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA-----------------RE----- 903
Query: 614 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE---ANAFVGQVKA 670
P ST V + + DVNDN P F +P N V E + ++A
Sbjct: 904 ---------EPQLFSTVVVKVSLEDVNDNPPTF---IPPNYRVKVREDLPEGTVIMWLEA 951
Query: 671 TDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATD-GA 724
DPD G +GQV YSL GNF+ +G++ +L+ E + Y L V A D G
Sbjct: 952 HDPDLGQSGQVRYSLLDHGEGNFD---VDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGK 1008
Query: 725 VHPRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL--GAN 780
ST + ++V+D+++N PVF++ V+E+ P G+ ++ + A D D
Sbjct: 1009 PVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGE 1068
Query: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIA 839
+ Y IR F + TG + LD E+ S +L G +P
Sbjct: 1069 IRYSIRDGSGVGVFKIGEETGVIETSDRLDRES-----TSHYWLTVFATDQGVVPLSSFI 1123
Query: 840 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP--ITTVYAEDADPPGLPASRVRYRVD 897
+ + V+D+ND P S+ +Y P+ ++ +P ++ V E DP ++ Y++
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVY----YPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKIT 1179
Query: 898 DVQFPYPASIFEVEEDSGRVITRV-NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 956
P F + +G + T L+ E L V D+G P S+ A V + +L
Sbjct: 1180 SGN---PQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKIL 1236
Query: 957 HPGE-IPRFTQEEYR-------PPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNE 1005
+ P+F Q+ Y+ P A + + VI+ N I YSI GNE
Sbjct: 1237 DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNE 1296
Query: 1006 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1065
F I TGV+ + + + D L + + P KS+T +++IE
Sbjct: 1297 HGKFFIEPKTGVV---------SSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWIS 1347
Query: 1066 E---NNHPPVFQKKFYIGGVSE 1084
+ + P F++ F+ V E
Sbjct: 1348 KPKPSLEPISFEESFFTFTVME 1369
Score = 197 bits (500), Expect = 1e-49
Identities = 271/1068 (25%), Positives = 432/1068 (40%), Gaps = 166/1068 (15%)
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT---VDVLDGDDLGPMFLP 267
TG I++ K L+ E K+ Y + ++A D TTT LT + V+D +D P F
Sbjct: 1408 TGTIIVAKPLDAEQKSNYNLTVEATDG---------TTTILTQVFIKVIDTNDHRPQFST 1458
Query: 268 CVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSIL 327
Y+ IPE PE I+ I A+DQD ++ ++Y++
Sbjct: 1459 S------------KYEVVIPEDTAPE--TEIL---QISAVDQD-------EKNKLIYTLQ 1494
Query: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
+ F + P T L E ++ + + L + + FA + + + D
Sbjct: 1495 SSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSD 1554
Query: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
N+ +P+FT SY+G + ESA VG+ + L++ ALDKD + + +
Sbjct: 1555 TNDHAPWFTASSYKGRVYESAAVGSVV---------LQVTALDKDKGKNAEVLYSIESGN 1605
Query: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDN 505
+ F + + + + +DR Q Y + A D SE V I V A++
Sbjct: 1606 IGNSFMIDP--VLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNA 1663
Query: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTA-------VDADEGSNGE--------------- 543
+P F Y V + + G V +TA + +G+ G+
Sbjct: 1664 SPKFTSKEYSVELSETVSIGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQK 1723
Query: 544 -ITYE----------------------ILVGAQGD------FIINKTTGLITIAPGVEMI 574
+ +E +LV Q + F+ + TGLI+ + + +
Sbjct: 1724 ALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSV 1783
Query: 575 V--GRTYALTVQAADNAPPA-------------------ERSTGILTLGKALDRESTDRY 613
V R L ++AAD + + STG + +LD E T +
Sbjct: 1784 VLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIF 1843
Query: 614 ILIITASD-GRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 670
+ D G P A V + V D+ND PVF L ++ V V A
Sbjct: 1844 HFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNA 1903
Query: 671 TDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 728
TD D+ Q+ YS+ GN F + T V+ ++R YEL V A+DG R
Sbjct: 1904 TDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT-VQNTTQLRSRYELTVRASDG----R 1958
Query: 729 HSTLT-LAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 787
+ LT + I V + ++ FT Y+ +V+EN T+ I A + + Y I +
Sbjct: 1959 FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHILN 2018
Query: 788 PEVKHFFALHPFTGELSLLRS-LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 846
P+ + F + +G LS + D E Q+ + +VE + + V VIV+
Sbjct: 2019 PDRR--FKISRTSGVLSTTGTPFDRE----QQEAFDVVVEVTEEHKPSAVAHVVVKVIVE 2072
Query: 847 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS 906
D ND PVF Y +V D G I V A D D V Y + + +
Sbjct: 2073 DQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGR--NGEVHYYLKEHHEHFQIG 2130
Query: 907 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQ 966
E + LN+E + + VVA D G P S+ V I V++ +P F +
Sbjct: 2131 PLG-EISLKKQFELDTLNKE----YLVTVVAKDGGNPAFSAEVIVPITVMNKA-MPVFEK 2184
Query: 967 EEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1026
Y + +V V + + + YSI G+ F IN TGVI V PLD+
Sbjct: 2185 PFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDF 2244
Query: 1027 ETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1085
E +Y L ++A DSL A + V I + D N++PPVF ++ Y +SE
Sbjct: 2245 EAHPAYKLSIRATDSLTGAHAEVFVD---------IIVDDINDNPPVFAQQSYAVTLSEA 2295
Query: 1086 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1145
+ + TSV++V+ATD D+ ++Y++ K + F V++ TGLI +
Sbjct: 2296 SVIGTSVVQVRATDSDSEPNRGISYQMFGNHSK-SHDHFHVDSSTGLISLLRTLDYEQSR 2354
Query: 1146 YFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKI 1193
V A D LS +DV+V+V V N P L E++I
Sbjct: 2355 QHTIFVRAVDGGMPTLS--SDVIVTV------DVTDLNDNPPLFEQQI 2394
Score = 188 bits (477), Expect = 5e-47
Identities = 280/1160 (24%), Positives = 458/1160 (39%), Gaps = 198/1160 (17%)
Query: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
Query: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
Query: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
L + ++ LTV + ++ P+ L P+ D
Sbjct: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
+P + DQ N S SI+ G R P + E + + +
Sbjct: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
Query: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
Query: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
+ ++ S LR V P F +Y T +++L+
Sbjct: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
Query: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
Query: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
Query: 587 DNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 646
D P R +L +T T+N ++NDN P+F
Sbjct: 542 DWGLPYRREVEVL----------------------------ATITLN----NLNDNTPLF 569
Query: 647 DPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIY 701
+ +PR+L V E+ + V A D D Q GN + F + N +
Sbjct: 570 EKINCEGTIPRDLGVGEQ-----ITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGV- 623
Query: 702 TAVKLNREVRD-------YYELVVVATDGA--VHPRHSTLT------------------- 733
+ L R + D ++ L + ATDG P + +T
Sbjct: 624 --LSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAK 681
Query: 734 -LAIKVL-------------------DIDDNSPVFTNSTYT-VLVEENLPAGTTILQIEA 772
LA K+L ++ + P F ++ T + V+EN P G++++ + +
Sbjct: 682 MLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNS 741
Query: 773 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 830
D+D G N + Y + F + TG L +L LD E +IT +D+
Sbjct: 742 TDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNIT----VYDL 797
Query: 831 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 890
+ V+V D ND PP F + Y V+ D + I V A D D P
Sbjct: 798 GIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLG--PNG 855
Query: 891 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG--EPVMSSS 948
V Y + F ++ +G V L+ E L + A D EP + S+
Sbjct: 856 HVTYSI-----VTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFST 910
Query: 949 ATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQS--IVYSIVSG 1003
VK+ + + P F YR V E +GT++ + A + QS + YS++
Sbjct: 911 VVVKVSLEDVNDNPPTFIPPNYR-VKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLD- 968
Query: 1004 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1063
+ E F ++ ++G + + LD+E + Y L V+A + S S+T V +E+
Sbjct: 969 HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD------KGKPVSLSSTCYVEVEV 1022
Query: 1064 QD--ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK 1121
D EN HPPVF G V EDA + + V+ V A D+D + Y + G
Sbjct: 1023 VDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI---RDGSGV 1079
Query: 1122 EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV--VNQLDMQV 1179
F + TG+I+T+ S++ V ATD LS ++ + V VN Q
Sbjct: 1080 GVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQT 1139
Query: 1180 IVSNVPPTLVEKKIEDLTEI 1199
P ++E +D++ +
Sbjct: 1140 SEPVYYPEIMENSPKDVSVV 1159
Score = 185 bits (470), Expect = 3e-46
Identities = 270/1183 (22%), Positives = 463/1183 (39%), Gaps = 202/1183 (17%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
Query: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
Query: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
Query: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
Query: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
Query: 543 EITYEIL-------VGAQGDFIINKTTGLITI----------------APGVEMIVGRT- 578
E+ Y + +G G+ + K L T+ A E+IV T
Sbjct: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITV 2174
Query: 579 -----------------------YALTVQAADNAPPAER------------------STG 597
++ V N+P + +TG
Sbjct: 2175 MNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTG 2234
Query: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
++ + LD E+ Y L I A+D + V+I+V D+NDN PVF ++ +V
Sbjct: 2235 VINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVF---AQQSYAVT 2291
Query: 658 EEEANAF---VGQVKATDPDAGINGQVHYSL-GNFNNL---FRITSNGSIYTAVK-LNRE 709
EA+ V QV+ATD D+ N + Y + GN + F + S+ + + ++ L+ E
Sbjct: 2292 LSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYE 2351
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 769
+ + V A DG + S + + + V D++DN P+F Y + E+ P G +
Sbjct: 2352 QSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTC 2411
Query: 770 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 827
++A D D + Y I S F + TG ++L + P +++
Sbjct: 2412 VKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSDGV 2471
Query: 828 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 887
F V V V N + P F + Y+ +A +A T + V D D G+
Sbjct: 2472 F-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGD-SGI 2523
Query: 888 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFDDGEPVM 945
+ V+D + F + E G++ T L+ E + + ++A D G V
Sbjct: 2524 YGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVA 2578
Query: 946 SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIV 1001
+ V IL P+F +Y + A KGT V + A+ N I Y+I
Sbjct: 2579 FCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDADEGSNADITYAIE 2636
Query: 1002 SGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1056
+ +E ++ IN ++GVI L+ E T +V V S PSK +
Sbjct: 2637 ADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS----------PSKESV 2686
Query: 1057 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1116
VY++I P F + FY VSED + T + ++A T YS++ P
Sbjct: 2687 VLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGN---TP 2743
Query: 1117 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKGLSGKADVLVSVVN 1173
E FV++ +G +K + +++F ++A DD+ + DV + V +
Sbjct: 2744 ESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--EMVASVDVSIQVKD 2801
Query: 1174 QLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1216
D + + P + ++ E +PG V++
Sbjct: 2802 ANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
Score = 185 bits (469), Expect = 4e-46
Identities = 259/1081 (23%), Positives = 443/1081 (40%), Gaps = 142/1081 (13%)
Query: 111 IHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
++++ V+ + K V + Y EV +V + N + P F TV E PVG+ + T
Sbjct: 996 VYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055
Query: 169 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 228
A D D +G+I Y I+ D + F+I TG I RL+ E + Y
Sbjct: 1056 -----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIETSDRLDRESTSHY 1105
Query: 229 FVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE 288
++ + A D+ ++ + ++V D +D P V P +
Sbjct: 1106 WLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME------------ 1150
Query: 289 LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELS 348
+P++++ + I+A D D S ++Y I G P+ FF +HP+T ++
Sbjct: 1151 -NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG---FFSIHPKTGLIT 1197
Query: 349 LL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 407
++R+ + L + + P A + ++ILDEN+ P F Y+ + E
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER 1257
Query: 408 APVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYL 463
+ PL ++A DKD + + E+ + N++ F +TG+
Sbjct: 1258 EKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSK 1312
Query: 464 TLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT-DM 522
+ + SI A D + + + + + P+ IS++ +T +
Sbjct: 1313 RFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTV 1367
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYAL 581
D V + V + E + ++I G F ++K TG I +A ++ Y L
Sbjct: 1368 MESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNL 1427
Query: 582 TVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVND 641
TV+A D +T IL T +I +I +D RP ST+ +V+ + D
Sbjct: 1428 TVEATDG------TTTIL----------TQVFIKVIDTNDHRPQ-FSTSKYEVVIPE--D 1468
Query: 642 NAPVFDPYLPRNLSVVEEEANAFVGQVKAT-DPDAGINGQVHYSLGNFNNLFRITSNGSI 700
AP + + + +V ++E N + ++++ DP SL F + GS+
Sbjct: 1469 TAP--ETEILQISAVDQDEKNKLIYTLQSSRDP---------LSLKKFR---LDPATGSL 1514
Query: 701 YTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 760
YT+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 1515 YTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYES 1574
Query: 761 LPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 818
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +
Sbjct: 1575 AAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQ 1630
Query: 819 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 878
A +V+A D I +V + V ++ P F+ + Y ++ G+ + V
Sbjct: 1631 AEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVT 1690
Query: 879 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 938
A S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 1691 AHS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII--- 1737
Query: 939 DDGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVIS 988
G + S +LV E P F Q EY +SE A+ ++V VI
Sbjct: 1738 -QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIR 1795
Query: 989 AAAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1044
AA N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1796 AADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTP 1855
Query: 1045 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1104
A V + + D N+ PPVF K Y + V+ V ATD D+
Sbjct: 1856 RL-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSA 1910
Query: 1105 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGL 1161
+S + Y + EG + E ++ KT L RS ++ V A+D GL
Sbjct: 1911 FSQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGL 1962
Query: 1162 S 1162
+
Sbjct: 1963 T 1963
Score = 168 bits (426), Expect = 4e-41
Identities = 223/926 (24%), Positives = 386/926 (41%), Gaps = 171/926 (18%)
Query: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 167 SIA---------RVSATDADI--GTNGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
Query: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSP-SELDRD 270
Query: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
Query: 579 -------YALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 631
Y LT+QA D P + S+ +I S G
Sbjct: 325 WDSHPFGYNLTLQAKDKGTPPQFSS----------------VKVIHVTSPQFKAGPVKFE 368
Query: 632 VNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL 691
++ ++++ AP P + V A + + V + P G+ +SL N+N
Sbjct: 369 KDVYRAEISEFAPPNTPV----VMVKAIPAYSHLRYVFKSTP-----GKAKFSL-NYN-- 416
Query: 692 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 751
G I + R+ ++EL V +D R ++ + +KVL + N P FT +
Sbjct: 417 -----TGLISILEPVKRQQAAHFELEVTTSD-----RKASTKVLVKVLGANSNPPEFTQT 466
Query: 752 TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF-FALHPFTGELSLLRS 808
Y +EN+P GTT++ + A D D G N V+Y I + + H FA+ FTG +S +
Sbjct: 467 AYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN--LNHVPFAIDHFTGAVSTSEN 524
Query: 809 LDYEAFPDQEASITFLVEAFD---IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVA 865
LDYE P T + A D Y +AT+T + ++ND P+F K +G +
Sbjct: 525 LDYELMP---RVYTLRIRASDWGLPYRREVEVLATIT--LNNLNDNTPLFEKINCEGTIP 579
Query: 866 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV-------- 917
D G ITTV A DAD L V+Y+++ F + +SG +
Sbjct: 580 RDLGVGEQITTVSAIDADELQL----VQYQIEAGN---ELDFFSLNPNSGVLSLKRSLMD 632
Query: 918 ------------ITRVNLNEEPTTIFKLVVVAF----------DDGEPVMSSSATVKILV 955
IT + T ++ + VA + G M + ++
Sbjct: 633 GLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANK 692
Query: 956 LH-PGE--------------IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSI 996
LH GE IP+F V E G+ V +++ N +
Sbjct: 693 LHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKL 752
Query: 997 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1056
VY++ GNE+ F I+ TG++ + PLD ET Y +L + + +L +P K+
Sbjct: 753 VYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY-------TLNITVYDLGIPQKAAW 805
Query: 1057 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1116
+++ + D N++PP F ++ Y VSED + + +++V+ATDKD G + Y ++
Sbjct: 806 RLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIV--- 862
Query: 1117 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
+ F +++ TG++ A + ++ A D + + + +VV ++
Sbjct: 863 --TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQARE----EPQLFSTVVVKVS 916
Query: 1177 MQVIVSN----VPPTLVEKKIEDLTE 1198
++ + N +PP K EDL E
Sbjct: 917 LEDVNDNPPTFIPPNYRVKVREDLPE 942
Score = 128 bits (322), Expect = 5e-29
Identities = 149/604 (24%), Positives = 245/604 (40%), Gaps = 94/604 (15%)
Query: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRV-----QATDADAGLNR 3158
Query: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
Query: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
Query: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
Query: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
Query: 486 GVQESE--PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
Query: 544 ITYEILVGAQGD--FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTL 601
+ +V + F +N L+T
Sbjct: 3475 PFFFTIVTGNDEKAFEVNPQGVLLT----------------------------------- 3499
Query: 602 GKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
A+ R+ D Y+L + +D G+P +S ++I V + + P P S EE
Sbjct: 3500 SSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEY 3559
Query: 661 ANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 719
+ +G++ ATD D + + YSL +NLF ++S G A K ++ Y L V
Sbjct: 3560 SGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKLIAHK-KLDIGQYL-LNVS 3615
Query: 720 ATDG 723
TDG
Sbjct: 3616 VTDG 3619
Score = 118 bits (295), Expect = 6e-26
Identities = 132/499 (26%), Positives = 222/499 (44%), Gaps = 39/499 (7%)
Query: 683 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
Y LG+F L T G+ TA+ LNREV+D+Y L+V A + + T + ++VLD +
Sbjct: 88 YILGDFCFLRIRTKGGN--TAI-LNREVKDHYTLIVKALEKNTNVEART-KVRVQVLDTN 143
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802
D P+F+ ++Y+V + EN T+I ++ A D D+G N + + FA+HP +G
Sbjct: 144 DLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGV 203
Query: 803 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYK 861
+ L LDY E I +YG+ +A +TV ++ N+ PV I
Sbjct: 204 IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPV----ITA 259
Query: 862 GMVAPDAVKGTP---ITTVYAEDADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRV 917
++P + P I TV D G AS D + QF S +E +
Sbjct: 260 VTLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
Query: 918 ITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP----GEIPRFTQEEYRPPP 973
I ++ + P + L + A D G P SS V I V P G + +F ++ YR
Sbjct: 320 IGGIDWDSHPFG-YNLTLQAKDKGTPPQFSSVKV-IHVTSPQFKAGPV-KFEKDVYR-AE 375
Query: 974 VSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYV 1033
+SE A T V ++ A + Y S + F +N TG+I + P V
Sbjct: 376 ISEFAPPNTPVVMVKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEP---------V 426
Query: 1034 LRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1093
R QA E+ + + + KV +++ N++PP F + Y E+ + T+V+
Sbjct: 427 KRQQAAHFEL---EVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
Query: 1094 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA-MLFHNMRRSYFKFQVI 1152
+ A D D G + Y + F ++ +TG + T+ L + + + ++
Sbjct: 484 SLSAVDPDEGENGYVTYSI----ANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIR 539
Query: 1153 ATDDYGKGLSGKADVLVSV 1171
A+ D+G + +VL ++
Sbjct: 540 AS-DWGLPYRREVEVLATI 557
Score = 107 bits (266), Expect = 1e-22
Identities = 202/894 (22%), Positives = 349/894 (39%), Gaps = 142/894 (15%)
Query: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
Query: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 166 TSIARVSATDADIGTNGEFYYS-FKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
Query: 586 ADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 645
AD S+GI +S A + + + N+ APV
Sbjct: 225 ADRGMKLYGSSGI----------------------------SSMAKLTVHIEQANECAPV 256
Query: 646 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQV---HYSLGNFNNLFRITSN--GSI 700
LS E + + V D D G NG + G+ FR + GS
Sbjct: 257 ITAV---TLSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSK 313
Query: 701 YTAVK----LNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYT 754
VK ++ + + Y L + A D P+ S++ + PV F Y
Sbjct: 314 EYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYR 373
Query: 755 VLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 814
+ E P T ++ ++A + +++ Y +S K F+L+ TG +S+L E
Sbjct: 374 AEISEFAPPNTPVVMVKA--IPAYSHLRYVFKSTPGKAKFSLNYNTGLISIL-----EPV 426
Query: 815 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDM--NDYPPVFSKRIYKGMVAPDAVKGT 872
Q+A+ F++ T A+ V+VK + N PP F++ YK + GT
Sbjct: 427 KRQQAA------HFELEVTTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGT 480
Query: 873 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE-PTTIF 931
+ ++ A DP V Y + ++ F ++ +G V T NL+ E ++
Sbjct: 481 TVMSLSA--VDPDEGENGYVTYSIANLNH----VPFAIDHFTGAVSTSENLDYELMPRVY 534
Query: 932 KLVVVAFDDGEPVMSSSATVKILVLH--PGEIPRFTQEEYRPPPVSELATKGTMVGVISA 989
L + A D G P + + L+ P F + +L G + +SA
Sbjct: 535 TLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGV-GEQITTVSA 593
Query: 990 AAIN--QSIVYSIVSGNEEDTFGINNITGVIYVNGPL--DYETRTSY-VLRVQADS---- 1040
+ Q + Y I +GNE D F +N +GV+ + L + S+ LR+ A
Sbjct: 594 IDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENF 653
Query: 1041 ------------------------------LEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070
E +L ++ ++ ++ + N H
Sbjct: 654 ATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHI 713
Query: 1071 PVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVE 1127
P F+ G V E+ + +SV+ + +TD DTG + Y + G E F+++
Sbjct: 714 PQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVY-----AVSGGNEDSCFMID 768
Query: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPT 1187
TG++K +L R + K+ + T Y G+ KA + V +D N P
Sbjct: 769 METGMLK--ILSPLDRETTDKYTLNIT-VYDLGIPQKAAWRLLHVVVVDAN---DNPPEF 822
Query: 1188 LVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRH--------GDAFSLEDYT 1233
L E +++E D+ V +I + + +G H D FS++ T
Sbjct: 823 LQESYFVEVSE--DKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVT 874
Score = 54.7 bits (130), Expect = 8e-07
Identities = 106/442 (23%), Positives = 175/442 (39%), Gaps = 67/442 (15%)
Query: 748 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGA-------NVSYRIRSPEVKHFFALHPF- 799
FT+ Y V V+EN A T + V +G V Y+I S + ++ F +
Sbjct: 34 FTHLEYNVTVQENSAAKTYV----GHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI 89
Query: 800 TGELSLLR---SLDYEAFPDQEAS--ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 854
G+ LR A ++E T +V+A + T V V V D ND P+
Sbjct: 90 LGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALE-KNTNVEARTKVRVQVLDTNDLRPL 148
Query: 855 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 914
FS Y + + T I V A DAD + + Y F +F + S
Sbjct: 149 FSPTSYSVSLPENTAIRTSIARVSATDAD---IGTNGEFY----YSFKDRTDMFAIHPTS 201
Query: 915 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS--ATVKILVLHPGEIPRFTQEEYRPP 972
G ++ L+ T ++++ ++A D G + SS +++ L +H ++
Sbjct: 202 GVIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVH-------IEQANECA 254
Query: 973 PVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT-- 1030
PV T +S + +++ Y+IV+ ++ D +I + V G L + RT
Sbjct: 255 PVITAVT-------LSPSELDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVR 307
Query: 1031 ----SYVLRVQA------DS------LEVVLANLRVPSKSNTAKVYIEIQDENNHPPV-F 1073
S +V+A DS L + + P + ++ KV + PV F
Sbjct: 308 SFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKF 367
Query: 1074 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI 1133
+K Y +SE A T V+ VKA YS + Y P GK F + TGLI
Sbjct: 368 EKDVYRAEISEFAPPNTPVVMVKAIPA----YSHLRYVFKSTP---GKAKFSLNYNTGLI 420
Query: 1134 KTAMLFHNMRRSYFKFQVIATD 1155
+ ++F+ +V +D
Sbjct: 421 SILEPVKRQQAAHFELEVTTSD 442
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 264 bits (674), Expect = 7e-70
Identities = 285/1108 (25%), Positives = 481/1108 (43%), Gaps = 145/1108 (13%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
+PE +P T I D D ++ P +++S +
Sbjct: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Query: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
Query: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 574
V VIQ+ A D D G NG I Y IL G Q
Sbjct: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQ--------------------- 1831
Query: 575 VGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 633
+ A + +G++T LD E T Y LI+ A+D G P ++T +
Sbjct: 1832 ------------EEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIK 1879
Query: 634 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--- 690
+ VTD+NDNAP F LP + E++ V + D +N +S +N
Sbjct: 1880 VQVTDINDNAPAF---LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGT 1936
Query: 691 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 749
F I N + VK L+ E YEL++ +D +VH ++ L ++VLD++DN PVF+
Sbjct: 1937 KFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFS 1993
Query: 750 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 809
Y V V E++P G ++L + A D++ N+SYRI S + F++ P G + + +
Sbjct: 1994 QDFYQVTVPESIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV 2051
Query: 810 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 869
D ++ FLVEA D + V + ++DMN+Y P F+ + Y ++ DA+
Sbjct: 2052 ---LLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDAL 2108
Query: 870 KGTPITTVYAEDADPPGLPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVN 922
G+ + T D D + V Y + F F E + G ++ +
Sbjct: 2109 VGSTLVTFSNIDHDWT-RENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
Query: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKG 981
L+ E + +LV++A D G P +SS+A + I VL + P F+ Y V E G
Sbjct: 2168 LDREASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH-THVKESTPLG 2226
Query: 982 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
+ + V+SA + I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQ
Sbjct: 2227 SHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQ 2286
Query: 1038 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
A E + A V++ + D+N+H P F + V E+ + +++ + A
Sbjct: 2287 ASDAE--------KKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINA 2338
Query: 1098 TDKDTGNYSVMAYRLIIP-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1152
D D G Y + Y ++ P + + F+++ TG I + + + V
Sbjct: 2339 LDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQ 2398
Query: 1153 ATDDYGKGLSGKADVLVSVVNQLDMQVI 1180
A D K D S+V +D++ I
Sbjct: 2399 AKD--------KGDATASLVVWVDIEGI 2418
Score = 258 bits (660), Expect = 3e-68
Identities = 279/1059 (26%), Positives = 448/1059 (42%), Gaps = 158/1059 (14%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ +LD +D P F+ + P E++ + I A D
Sbjct: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
Query: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
Query: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
Query: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
+ G + F IN+ +G L+ +ALDR
Sbjct: 1413 IDGNTDECFTINE----------------------------------MSGELSTTRALDR 1438
Query: 608 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFV 665
E + L+I SD G P +S + + V D ND++P F P L SV E+ E V
Sbjct: 1439 EQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSF-PTLYYQSSVREDAEVGTVV 1497
Query: 666 GQVKATDPDAGINGQVHYSL-GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDG 723
+ A D D G+NGQ Y L + F I +G++ T+ L+RE R + VA D
Sbjct: 1498 LVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDC 1557
Query: 724 AVH-PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVS 782
++ R +T+ + + V D++DN PV + + V + P T + + A D+DLG N +
Sbjct: 1558 SIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGT 1617
Query: 783 YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVT 842
E + F++ +TGE+ ++ E FP I ++ D G +
Sbjct: 1618 VVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFP-----IWLQLKVTD-QGIPARTTTGLL 1671
Query: 843 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 902
VI + D FS +YKG+V + GT I TV A + D +Q
Sbjct: 1672 VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA--------------FAPDSIQDS 1717
Query: 903 YPASIFEVEED--------SGRVITRVN--LNEEPTTIFKLVVVAFDDGEPVMSSSATVK 952
SIF ED SG++ + L+ E +L+V+A G A K
Sbjct: 1718 MKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH-----RAYCK 1772
Query: 953 ILVLHPGE---IPRFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEE 1006
+ VL E P F Q Y+ ++ V + + +N I YSI+SGN+E
Sbjct: 1773 VAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQE 1832
Query: 1007 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
+ F I+ ++GVI LDYE +SY L VQA + +P SNT + +++ D
Sbjct: 1833 EAFQIDALSGVITTKAILDYELTSSYSLIVQA-------TDKGMPRLSNTTVIKVQVTDI 1885
Query: 1067 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--F 1124
N++ P F + ++ED+ V V D D + + ++ KE G F
Sbjct: 1886 NDNAPAFLPSEAV-EITEDSLPGVIVTHVSVHDVDLNSAFIFSF------AKESNPGTKF 1938
Query: 1125 VVETYTG---LIKTAMLFHNMRRSYFKFQVIATDDYGKG 1160
++ TG L+KT + F M Q+ + Y +G
Sbjct: 1939 AIDQNTGVVVLVKT-LDFEEMTEYELLIQISDSVHYTEG 1976
Score = 242 bits (617), Expect = 3e-63
Identities = 265/1031 (25%), Positives = 452/1031 (43%), Gaps = 140/1031 (13%)
Query: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
Query: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
Query: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
Query: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Query: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
Query: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
Query: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
Query: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
D G V+ L+AVD DEG NG+ Y F+ ++ +G TI P
Sbjct: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEY---------FLTDEASGAFTIDP--------- 1529
Query: 579 YALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVV 636
+G L LDRE+ ++ A D G+ + TV + V
Sbjct: 1530 ----------------MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYV 1573
Query: 637 TDVNDNAPV-----FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL 691
TDVNDN PV FD +L E N V+A D D G NG V +S ++
Sbjct: 1574 TDVNDNDPVLEQNPFDVFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSM 1628
Query: 692 FRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN 750
F I G I + E + + V G P +T L + ++ +D F++
Sbjct: 1629 FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSH 1686
Query: 751 STYTVLVEENLPAGTTILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--R 807
Y LV EN AGT+I+ ++A D + ++ Y I S +L +G+L++ +
Sbjct: 1687 HLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPK 1746
Query: 808 SLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 867
LD+E E + L E+ + V V+++D ND P F + IY+ V+
Sbjct: 1747 FLDFEV--RNEVQLIVLAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSES 1799
Query: 868 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 927
+ + V+A D D GL + Y + F+++ SG + T+ L+ E
Sbjct: 1800 QLYNAHVIQVFATDLD-SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYEL 1854
Query: 928 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGV 986
T+ + L+V A D G P +S++ +K+ V + P F E ++E + G +V
Sbjct: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTH 1912
Query: 987 ISA--AAINQSIVYSIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1042
+S +N + ++S + T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1913 VSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVH 1972
Query: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
+ + + D N++PPVF + FY V E + SVL + ATD ++
Sbjct: 1973 Y-----------TEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES 2021
Query: 1103 GNYSVMAYRLI 1113
++YR++
Sbjct: 2022 NEN--ISYRIL 2030
Score = 236 bits (602), Expect = 2e-61
Identities = 288/1128 (25%), Positives = 481/1128 (42%), Gaps = 124/1128 (10%)
Query: 180 DDGPNGQIEYVIQYNPDDP-----TSNDT---FEIPLMLTGNIVLRKRLNYEDKTRYFVI 231
+D P G ++ N +P +S D F I L G I RK L++E + +
Sbjct: 392 EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRL-GTIRTRKPLDHETQPVVVLT 450
Query: 232 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 291
+QA Q + ++T + + V+D +D P FL RT
Sbjct: 451 VQA----QLGSAPACSSTEVNITVMDVNDNHPAFL-----------------------RT 483
Query: 292 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLL 350
+E+ TPP A+ R S R G++ YSI +P+ P F + L L
Sbjct: 484 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSI--ASPQ--PGVFAIDRALGVLFLN 539
Query: 351 EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS--YQGYILES- 407
+ ++ L ++AE HP A L + ++++ SP +T YQ + ES
Sbjct: 540 GSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHSPSWTFEHLVYQVEVSESL 598
Query: 408 APVGATISDSLNLTSPLRIVA-LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
+P+ + + P R + L +E + D + + YT ++ L
Sbjct: 599 SPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM-FGIRPYTG-----------WIYLR 646
Query: 467 QPVDREEQQTYTFSITAF---DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
+ D E QTY F + A+ DG ++ V ++V D NDN+PTF + V
Sbjct: 647 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPV 706
Query: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTG------LITIAPGVEMIVG 576
P + ++TA+D D G NG++ Y +L + G F +N TG +IT A G G
Sbjct: 707 PQGVIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGPAGTIYVITWADGAAAFSG 764
Query: 577 RTYALTVQAAD----NAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT 631
+A + + E G L ALDRE + + + +D G P +T
Sbjct: 765 TDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMA 824
Query: 632 VNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLG- 686
V + VTD+NDN P F LP ++ V+E + N V V A DPD G N +V YS+
Sbjct: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 884
Query: 687 -NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 744
+ ++ F+I +NG I T L+ + R Y + V+ATD V P + I+V+ +
Sbjct: 885 EDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKG 944
Query: 745 SPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTG 801
+ + + +++ ENL + I++ D + + I + + F + TG
Sbjct: 945 RAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTG 1004
Query: 802 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 860
+L L + LDYE + F V D + +++ V+D ND+ P F +
Sbjct: 1005 DLFLSKELDYET----TSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELI 1060
Query: 861 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 920
V + GT + A+D D L SR++Y ++ + F + G ++T
Sbjct: 1061 VISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYYIE--SHNPGTNPFLIHPSFGTLVTV 1117
Query: 921 VNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVKILVLHPGE-IPRFTQEEYRPPPVSE 976
L+ E L V A D V S T +I++L + P F + V E
Sbjct: 1118 SRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI--SFPNAHVKE 1175
Query: 977 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1032
T G++V I+A N + YSI+SGNE TF ++ +G++ PLDYE +T +
Sbjct: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235
Query: 1033 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1092
+L V A + P+ S++ + + + D N+ PVF++ Y V E+ V
Sbjct: 1236 ILTVLA-------LDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFV 1288
Query: 1093 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1152
RV+A D+D+G S + + I+P E F + + TG + T + + F +V+
Sbjct: 1289 TRVEALDRDSGVNSKLQFE-IMP--GASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345
Query: 1153 ATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAK 1212
D LS +L +V ++ D + P +V D+ E+L+ E +
Sbjct: 1346 VRDGGFPSLSSTTTILCTVEDEND------HAPEFIVSS--YDI-EVLENQEPEVVYTVL 1396
Query: 1213 VVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ--TNRAIDRNELFKF 1258
G R + ++ T T+ + + T RA+DR ++ F
Sbjct: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQISNF 1444
Score = 188 bits (478), Expect = 4e-47
Identities = 266/1135 (23%), Positives = 437/1135 (38%), Gaps = 173/1135 (15%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ D L L G++ E+R T TL
Sbjct: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
Query: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
+ T +T + + V + V D NDN
Sbjct: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD 621
G I T+ + D P S +I
Sbjct: 897 NGEIR-------------TTTILSYDYRPSYRMS--------------------VIATDQ 923
Query: 622 GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDP-DAGING 679
G P A VNI V ++ + + R+L + E + + +K++D NG
Sbjct: 924 GVPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQQHYNG 982
Query: 680 QVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH-PRHSTLTLA 735
++H+S+ + + F I +S G ++ + +L+ E +Y V+ TD + + ST+ L+
Sbjct: 983 KLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLS 1042
Query: 736 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD---LGANVSYRIRSPEV-K 791
I V D +D+SP F + + VEEN+P GT + AKD D L + + Y I S
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGT 1102
Query: 792 HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
+ F +HP G L + LD E+ P ++T +A ++ + T +++ D+ND+
Sbjct: 1103 NPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSL-TAQIVILDVNDH 1161
Query: 852 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 911
P F V D G+ + + A D D +V Y + F ++
Sbjct: 1162 NPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEG--RNGKVTY---SILSGNENMTFMLD 1215
Query: 912 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYR 970
E SG + T L+ E T L V+A DDG P +SSS T+ + VL E P F Q Y
Sbjct: 1216 ESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYE 1275
Query: 971 PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1026
V E G V + A + +N + + I+ G + F IN+ TG + LD
Sbjct: 1276 -ASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDR 1334
Query: 1027 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1086
E + + LR V++ + PS S+T + ++DEN+H P F Y V E+
Sbjct: 1335 EIQEVFTLR-------VLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQ 1387
Query: 1087 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRR 1144
V V A+D D GN + Y +I +G E F + +G + T +
Sbjct: 1388 EP-EVVYTVLASDMDAGNNRAVEYHII-----DGNTDECFTINEMSGELSTTRALDREQI 1441
Query: 1145 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEI 1199
S F ++ +D G ++ V+ V LD + P + + + E+
Sbjct: 1442 SNFTLVILCSD---LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEV 1493
Score = 169 bits (428), Expect = 2e-41
Identities = 278/1103 (25%), Positives = 441/1103 (39%), Gaps = 159/1103 (14%)
Query: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
Query: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
Query: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
Query: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Query: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
Query: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
YQ + ES A + +++ A D D E + + F + +
Sbjct: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
Query: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
Query: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
+ D PG V ++ D D S ++ E G
Sbjct: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSF-----------------------AKESNPGT 1936
Query: 578 TYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 637
+A+ +++TG++ L K LD E Y L+I SD V ++
Sbjct: 1937 KFAI-----------DQNTGVVVLVKTLDFEEMTEYELLIQISDSVHYTEGALVVRVL-- 1983
Query: 638 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-S 696
DVNDN PVF + V + ATD ++ N + Y + + + F I
Sbjct: 1984 DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NENISYRILSSSKEFSIDPK 2041
Query: 697 NGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYT 754
NG+I+T + L + + +V A+DG +P LTL I + D+++ +P FT +Y
Sbjct: 2042 NGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEIGIEDMNNYAPEFTVKSYN 2100
Query: 755 VLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP--------EVKHFFALHPF--TG 801
+ + E+ G+T++ D D V Y I S E K F + +P+ G
Sbjct: 2101 LSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVG 2160
Query: 802 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 861
L LL SLD EA AS ++ A D A +++ V D+ND PP FS Y
Sbjct: 2161 YLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYH 2216
Query: 862 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 921
V G+ IT V A D D G A + + + + F +EE++G +
Sbjct: 2217 THVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH----FYLEENTGVLYLIK 2271
Query: 922 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATK 980
L+ E T F L V A D E S A V + VL + P+F + L
Sbjct: 2272 PLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPIS 2330
Query: 981 GTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGINNITGVIYVNGPLDYETR 1029
T+ + + A + YSIVS + D F I+ +TG I+ LDYE
Sbjct: 2331 STICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENG 2390
Query: 1030 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1089
Y L VQA A+L V+++I+ + P+F + Y + E +
Sbjct: 2391 NKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDR 2441
Query: 1090 TSVLRVKATDKDTGNYSVMAYRL 1112
+ RV+A+D D G V+ Y L
Sbjct: 2442 QLIGRVEASDADAGIDGVILYSL 2464
Score = 166 bits (421), Expect = 2e-40
Identities = 250/1019 (24%), Positives = 417/1019 (40%), Gaps = 150/1019 (14%)
Query: 99 TGRV-LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
TG + ++P I +Q++ ++ + + ++ + D +F H Y V
Sbjct: 1635 TGEIQFQQNPSSEYFPIWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGLVT 1694
Query: 158 ELTPVGTTIFT--GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
E GT+I T F+ D+ I D ++Y I +D + + +G +
Sbjct: 1695 ENCEAGTSIVTVKAFAPDS----IQDS----MKYSIFSGNEDGVLSLCSK-----SGQLT 1741
Query: 216 LR--KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
++ K L++E + +I+ A + V + D +D P F +
Sbjct: 1742 VKEPKFLDFEVRNEVQLIVLAESSGHR------AYCKVAVLIQDENDNSPCFEQSI---- 1791
Query: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPE 332
YQA++ E + N ++ + A D D + G++ YSIL G E
Sbjct: 1792 --------YQASVSESQL---YNAHVIQ--VFATDLDSGLN------GLIEYSILSGNQE 1832
Query: 333 DYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQ 391
+ F + + ++ ++ + + L+++A D G P L + +++ D N+
Sbjct: 1833 EA---FQIDALSGVITTKAILDYELTSSYSLIVQAT-DKGMPRLSNTTVIKVQVTDINDN 1888
Query: 392 SPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
+P F +PS I E + G ++ + D D+ N T
Sbjct: 1889 APAF-LPSEAVEITEDSLPGVIVT---------HVSVHDVDLNSAFIFSFAKESNPGTKF 1938
Query: 452 FTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPE 511
TG+ + L++ +D EE Y I D V +E +V ++V+D NDN P F +
Sbjct: 1939 AIDQNTGV---VVLVKTLDFEEMTEYELLIQISDSVHYTEGALV-VRVLDVNDNPPVFSQ 1994
Query: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGV 571
Y V V + G SV+ L+A D + SN I+Y IL ++ I K + TI+P +
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSATDLE--SNENISYRILSSSKEFSIDPKNGTIFTISPVL 2052
Query: 572 EMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG-RPDGTSTA 630
LD ST +++ + ASDG PD +
Sbjct: 2053 --------------------------------LLDTISTTQFL--VEASDGGNPDLRALT 2078
Query: 631 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGINGQVHYSL 685
V I + D+N+ AP F NLS+ E+ A VG T D D N V YS+
Sbjct: 2079 LVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTRENTYVEYSI 2134
Query: 686 --GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL 732
GN N F + + G + L+RE +ELV++A+D P ST
Sbjct: 2135 ISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTA 2194
Query: 733 TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEV 790
++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y I S
Sbjct: 2195 VISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNE 2254
Query: 791 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 850
K F L TG L L++ LDYE + T V+A D A V V V D ND
Sbjct: 2255 KGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFVSVLDDND 2309
Query: 851 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-----PYPA 905
+ P F + +V + + I ++ A D D P + Y + F Y
Sbjct: 2310 HAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLTHGMSYDH 2367
Query: 906 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFT 965
+F ++ +G + + L+ E + L V A D G+ S V I + E P FT
Sbjct: 2368 DLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDEFE-PIFT 2426
Query: 966 QEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1022
Q++Y P + G + + A I+ I+YS+ G F +N G IY+
Sbjct: 2427 QDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTNGNIYLIR 2484
Query: 1023 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VFQKKFYI 1079
L S + + ++++ + + SK + V++ + + P VF F I
Sbjct: 2485 AL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVFASSFSI 2541
Score = 139 bits (351), Expect = 2e-32
Identities = 189/830 (22%), Positives = 329/830 (39%), Gaps = 115/830 (13%)
Query: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
L++ A+ G A + I I F P Y + E P S
Sbjct: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
Query: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
Query: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
NG I Y I G F I++ G++ + + R LT++A D + + +LT
Sbjct: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
Query: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 660
++I + P T V V +V+++ L +++ +
Sbjct: 572 --------------VVIEKREHSPSWTFEHLVYQV--EVSES-------LSPMTQMLQTQ 608
Query: 661 ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELV 717
A+ +G +A P + YSL + +F I G IY + + E Y
Sbjct: 609 AHP-LGPQRAASP-------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFR 660
Query: 718 VVA---TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 774
V A DG + ++ + T+ ++V D +DNSP F + + VEE+ I +I A D
Sbjct: 661 VFAWIPEDGFL--QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAID 718
Query: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITF 823
+D G N FF ++P TG + + + AF E
Sbjct: 719 MDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFV 778
Query: 824 LVEAFDIYGT---------------------------MPPGIATVTVIVK--DMNDYPPV 854
L F G PP AT+ V V D+ND P
Sbjct: 779 LKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPF 838
Query: 855 FSKRIYKGMVAPDAVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 910
F + + + ++G P +TTV+A+D D + V Y V + F++
Sbjct: 839 FPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKI 893
Query: 911 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYR 970
+ ++G + T L+ + +++ V+A D G P + A V I V+ + + R
Sbjct: 894 DANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIR 953
Query: 971 PPPVSELATKGTMVGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1025
+ E ++ +I ++ N + +SIV+ +++ F I++ TG ++++ LD
Sbjct: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
Query: 1026 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1085
YET + Y+ RV + + + S S+T + I+++D+N+H P FQ + + V E+
Sbjct: 1014 YETTSHYLFRV------ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEEN 1067
Query: 1086 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1135
+ T V A D D G++ + I G F++ G + T
Sbjct: 1068 VPIGTLVYVFNAKD-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
Score = 123 bits (309), Expect = 1e-27
Identities = 205/889 (23%), Positives = 346/889 (38%), Gaps = 182/889 (20%)
Query: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Query: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT------ 566
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +
Sbjct: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEIL 241
Query: 567 ----------IAPGVEMIV-------------------------------GRTYALTVQA 585
+ +EM + GR + ++
Sbjct: 242 SAVNFSADKEVMNSLEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKV 301
Query: 586 ADNAPPAERST--------------GILTLGKALDRESTDRYILIITASDGRPDGTSTAT 631
D A A+ GI+ L L + L+++A DG G TA
Sbjct: 302 QDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDG---GGLTAV 358
Query: 632 VNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVKATDPDAGINGQVH 682
+N VT +F L P+ +V E+ ++ +G VKA +P + +
Sbjct: 359 INADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIF 412
Query: 683 Y--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 739
Y S G+ F I G+I T L+ E + L V A G+ P S+ + I V+
Sbjct: 413 YRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVM 471
Query: 740 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALH 797
D++DN P F ++ + + + P GT + A+D D G N + Y I SP+ FA+
Sbjct: 472 DVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAID 530
Query: 798 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP--VF 855
G L L SL ++ +T + A D G P V +V + ++ P F
Sbjct: 531 RALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWTF 585
Query: 856 SKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEED 913
+Y+ V+ +P+T + A P P AS +RY ++ +++F +
Sbjct: 586 EHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP---SVDSAMFGIRPY 639
Query: 914 SGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHPGE-IPRFTQE--- 967
+G + R + E T + V A+ +DG + + S TV + V + P F +
Sbjct: 640 TGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFLHDVLF 698
Query: 968 ---EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT---GVIYV- 1020
E P P + G + + + N ++Y ++S + F +N T G IYV
Sbjct: 699 LKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTGPAGTIYVI 753
Query: 1021 ------------NGPLDYETRTSYVLR--------------VQAD-------SLEVVLAN 1047
+ + ++VL+ V D + V++ +
Sbjct: 754 TWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTD 813
Query: 1048 LRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMFTSVLRVKATDKDT 1102
P ++ T VY+ + D N++ P F K+ ++ V E + V V A D D
Sbjct: 814 RGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVNMLVTTVFAKDPDE 872
Query: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
GN + + Y + ++ + F ++ G I+T + R ++ VIATD L
Sbjct: 873 GNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ 929
Query: 1163 GKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRYVQ 1205
G+A V + V+ + I+S +P L KI L + D Q
Sbjct: 930 GQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQ 978
Score = 87.0 bits (214), Expect = 2e-16
Identities = 123/489 (25%), Positives = 204/489 (41%), Gaps = 84/489 (17%)
Query: 667 QVKATDPDAGINGQVHYSLGN------FNNLFRITSN-GSIYTAVKLNREVRD--YYELV 717
+V A+D D+G+ G + YSL + FRI + G I + ++RE RD Y+L+
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLL 136
Query: 718 VVATDGAVHPRHSTLTLA-----------IKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766
V A DG R + L L + + D++DN PVF STY + + GT
Sbjct: 137 VEAKDGD-EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
Query: 767 ILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG----ELSLLRSLDYEAFPDQEAS 820
I+ + A D D G V+Y + V F + TG E+ +L ++++ A + S
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVMNS 255
Query: 821 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK-----RIYKGMVAPDAVKGTPIT 875
+ + P + + +D F +KG +K
Sbjct: 256 LEMFL----------PLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLK----- 300
Query: 876 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 935
V E A G A+R Y A++ ++ + G + + L+ +T L+V
Sbjct: 301 -VQDEAASADGEAAAR-----------YVANLAKILGE-GIIYLTLPLSHLESTTLSLMV 347
Query: 936 VAFDDG--EPVMSSSATVKIL--VLHPGEI--PRFTQEEYRPPPVSELATKGTMVGVISA 989
A D G V+++ T+ I L P E P++T Y P + + +G + A
Sbjct: 348 SAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP------EDSPIGTVKA 401
Query: 990 -AAINQS--IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1046
+N S I Y I SG+ F I+ G I PLD+ET+ VL VQ A
Sbjct: 402 REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ--------A 453
Query: 1047 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYS 1106
L ++ +V I + D N++ P F + +S+ T++ +A D+D+G
Sbjct: 454 QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNG 513
Query: 1107 VMAYRLIIP 1115
++ Y + P
Sbjct: 514 LIRYSIASP 522
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 964 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1023
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
Query: 1024 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1079
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
Query: 1080 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1132
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
Score = 54.7 bits (130), Expect = 8e-07
Identities = 54/181 (29%), Positives = 77/181 (42%), Gaps = 31/181 (17%)
Query: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 584 QAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 643
+A D +R T + + L + A V + + DVNDN
Sbjct: 138 EAKDG--DEQRMTHLALVKGGLSAQ---------------------AFVRVDLEDVNDNH 174
Query: 644 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIY 701
PVF+P E + + V ATD D+GI G V Y L GN ++LF I S +Y
Sbjct: 175 PVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLY 234
Query: 702 T 702
+
Sbjct: 235 S 235
Score = 36.2 bits (82), Expect = 0.31
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 254 bits (650), Expect = 4e-67
Identities = 292/1159 (25%), Positives = 497/1159 (42%), Gaps = 158/1159 (13%)
Query: 48 EESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRV----- 102
E + GT ++D + I +G P TI DY ++ + +N G++
Sbjct: 2492 ENAMVGTKVIDLLAIDKDSG-PYGTI--------DYTIINKLASEKFSINPNGQIATLQK 2542
Query: 103 LDRDPPMNIHSIVVQVQCINKKVG-TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
LDR+ N V+ ++ + + G + + V+I++ D NDN P FK Y ++
Sbjct: 2543 LDRE---NSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVS 2599
Query: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRL- 220
+ + A D D+G N + Y + NP+D D EI +TG + ++ L
Sbjct: 2600 KDSPVIQVL-----AYDADEGQNADVTYSV--NPEDLVK-DVIEIN-PVTGVVKVKDSLV 2650
Query: 221 NYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPL 280
E++T F I +AQ D GP P+ P+
Sbjct: 2651 GLENQTLDFFI-----KAQ--------------------DGGP--------PHWNSLVPV 2677
Query: 281 TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI---QPPSDRPGILYSILVGTPEDYPR- 336
Q ++ P+ P+ + + + I + + + ++YS++ GT + +
Sbjct: 2678 RLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKD 2737
Query: 337 -FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
F + P T + + +P++ + + + + + A + + ++I++ D N+ P F
Sbjct: 2738 GVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVF 2797
Query: 396 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV- 454
Y+ + E+ PVG TS +++ A+DKD L + ++V +
Sbjct: 2798 EADPYKAVLTENMPVG---------TSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELF 2848
Query: 455 ---TQTGITRYLTLLQPVDREEQQTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPT 508
+++G ++T LQ +D E QTY F + A+D +Q S +V + + D NDN P
Sbjct: 2849 AIDSESG---WITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPR 2905
Query: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDAD-EGSNGEITYEILVGAQ-GDFIINKTTGLIT 566
F Y V + PG+ V L +DAD N ++T I G G F I++
Sbjct: 2906 FASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ------ 2959
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
VG + ++ + K LDRE T +Y+L +TASDG+
Sbjct: 2960 --------VGDEWRISSR------------------KTLDREHTAKYLLRVTASDGKFQ- 2992
Query: 627 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 685
++ TV I V DVNDN+P L + F+ +V ATD D N Q+ YSL
Sbjct: 2993 -ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLH 3051
Query: 686 GNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDN 744
G + F++ + G + T L+RE +D + LV ATDG + +TL ++ D++DN
Sbjct: 3052 GPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDN 3109
Query: 745 SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGEL 803
+P F S V V +N T + + A+D D GAN P+ + F++ TG +
Sbjct: 3110 APRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVI 3169
Query: 804 SLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKG 862
L + L +A + V A D+ +P + TVTV V + DY PVF +
Sbjct: 3170 RLEKPLQVRP----QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSV 3225
Query: 863 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922
V DA GT + + PG A + YRV F ++ +G + +
Sbjct: 3226 QVPEDAPPGTEVLQLAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNAS 3278
Query: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKG 981
L+ E + + L + +S TV + + E P+F Q+ Y V E A G
Sbjct: 3279 LDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVG 3337
Query: 982 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
++ +SA +N I YS++ GN+ F I+ G + V LD E +SY L+++
Sbjct: 3338 DVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLR 3397
Query: 1038 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
A + P + I++ D N++PP F + Y V E++ + + VL++
Sbjct: 3398 A-------TDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLIL 3450
Query: 1098 TDKDT-GNYSVMAYRLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATD 1155
+D D+ N ++R I +G G T G + TA + +++ Q+ A+D
Sbjct: 3451 SDPDSPENGPPYSFR-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASD 3505
Query: 1156 DYGKGLSGKADVLVSVVNQ 1174
LS V V V Q
Sbjct: 3506 SGIPPLSSLTSVRVHVTEQ 3524
Score = 242 bits (617), Expect = 3e-63
Identities = 277/1102 (25%), Positives = 456/1102 (41%), Gaps = 172/1102 (15%)
Query: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
Query: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
Query: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
Query: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
Query: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
Query: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
Query: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRES 609
G G F+I+ TGL++ A ++ + L V DN P+ +ST + +G
Sbjct: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVG------- 1231
Query: 610 TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV-----FDPYLPRNLSVVEEEANAF 664
+ DVNDN P+ F+ LP LS V
Sbjct: 1232 --------------------------ILDVNDNPPIFSHKLFNVRLPERLSPVSPGP--- 1262
Query: 665 VGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSNGSIYTAVKLNREVRDYYELV 717
V ++ A+D D G+NG+V YS+ + + + + S+ S +TA +Y L
Sbjct: 1263 VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTA-------GEYNILT 1315
Query: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEENLPAG--TTILQIEA 772
+ ATD P +++ L I+ + S + F + Y+ V E P ++ +E
Sbjct: 1316 IKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEG 1375
Query: 773 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 832
+ N+S + + F + TG + + R LD + ++ VE D G
Sbjct: 1376 RPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR----RRSNYNLTVEVTD--G 1425
Query: 833 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 892
+ ++ ++N + P F + Y+ V D V G + V A D D +
Sbjct: 1426 SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQD----KGKSL 1481
Query: 893 RYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 950
Y + Q P AS+F+++ SG ++T +++L P+ L V+ D P+ +
Sbjct: 1482 IYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ-HTLTVMVRDQEIPIKRNFVW 1540
Query: 951 VKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSG 1003
V I V LHP PRFTQ Y +A ++ V + A +N + YS++ G
Sbjct: 1541 VTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG 1597
Query: 1004 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1063
N E F IN + G+I + LD + L V+A+ + P + A V I +
Sbjct: 1598 NSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE-------DQGSPQWHDLATVIIHV 1650
Query: 1064 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG-KE 1122
+ P+F K Y + E + + +L V A Y ++EG K+
Sbjct: 1651 YPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYE----------LREGNKD 1700
Query: 1123 G-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIV 1181
G F + +Y+GLI T + + S ++ ++ G ++G ++ VV+ +D
Sbjct: 1701 GVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNMAGAFTDVMVVVDIIDEN--- 1752
Query: 1182 SNVPPTLVEKKIEDLTEILDRY 1203
N P L + ++E Y
Sbjct: 1753 DNAPMFLKSTFVGQISEAAPLY 1774
Score = 236 bits (603), Expect = 1e-61
Identities = 287/1075 (26%), Positives = 451/1075 (41%), Gaps = 151/1075 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
Query: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
Query: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
Query: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
Query: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
Query: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
G+++Y + + F I+ +G IT ++ +TY V A D+ + S
Sbjct: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLS-- 2887
Query: 598 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
S A V + +TD NDNAP F R V
Sbjct: 2888 ------------------------------SQALVQVSITDENDNAPRFASEEYRGSVVE 2917
Query: 658 EEEANAFVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVR 711
E V +K D D N QV + + G+ F I+ G I + L+RE
Sbjct: 2918 NSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHT 2977
Query: 712 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 771
Y L V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++
Sbjct: 2978 AKYLLRVTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVS 3034
Query: 772 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
A D+D N ++Y + P H F L P TGEL+ L +LD E ++ + +A D
Sbjct: 3035 ATDLDTDTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATD 3089
Query: 830 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 889
G A +T+ V+D+ND P F V + TP+ V+A D D
Sbjct: 3090 GGGRSCQ--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--N 3145
Query: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSS 948
++V Y + D + F ++ +G + L P +L V A D G P+ +S+
Sbjct: 3146 AQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTL 3201
Query: 949 ATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSG 1003
TV + V+ + +P F E+ V E A GT V + A + + Y +VSG
Sbjct: 3202 GTVTVSVVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSG 3258
Query: 1004 NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1063
NE+ F ++ TG++YVN LD+ET Y L ++ + S S+ V + I
Sbjct: 3259 NEQGRFRLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNI 3311
Query: 1064 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE- 1122
D N H P F + Y V E+A + +L V ATD+D S + Y LI G +
Sbjct: 3312 TDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQL 3366
Query: 1123 -GFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
F + G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 3367 GHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
Score = 230 bits (586), Expect = 1e-59
Identities = 244/899 (27%), Positives = 400/899 (44%), Gaps = 113/899 (12%)
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F ++ RT ++ + + DFH + + G A + I+I+D NN +P F
Sbjct: 406 FKLNARTGLITTTKLM--DFHDRAHYQLHIRTSPGQ---ASTVVVIDIVDCNNHAPLFNR 460
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
SY G + E+ P G TS L + A D+D + N Y +
Sbjct: 461 SSYDGTLDENIPPG---------TSVLAVTATDRDHGE----------NGYVTYSIAGPK 501
Query: 458 G----ITRYLTLL---QPVDRE-EQQTYTFSITAFDG---VQESEPVIVNIQVMDANDNT 506
I YL ++ +P+D E ++ YTF + A D + + V + +Q+ + NDN
Sbjct: 502 ALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQ 561
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLI 565
P F E++ + D G S++ ++A+D DE N + YEI+ G + ++ +N +G+I
Sbjct: 562 PMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNELEYFDLNHFSGVI 619
Query: 566 TIA-PGVEMIVGR--TYALTVQAADNAPPAERSTGILTLGKALDRE---STDR------- 612
++ P + + G+ +Y+L + A+D A +T +T+ K E + D+
Sbjct: 620 SLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQF 679
Query: 613 ------YILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFV 665
+I + + TS +T I N P F+ + P+++ V+E N +
Sbjct: 680 TKTILHFIGLQNQESSDEEFTSLSTYQI-----NHYTPQFEDHFPQSIDVLESVPINTPL 734
Query: 666 GQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATD 722
++ ATDPDAG NG++ Y + GN F I G + A L+ E ++Y L V D
Sbjct: 735 ARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYD 794
Query: 723 GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN-- 780
+ S L + V D +DN+P F Y + + E+ GTTI ++ KD D N
Sbjct: 795 LGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGR 854
Query: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGI 838
V Y + SP K F+LHP TGEL + LD E+ E VEA D G +
Sbjct: 855 VRYTLLSPTEK--FSLHPLTGELVVTGHLDRES----EPRYILKVEARDQPSKGHQLFSV 908
Query: 839 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 898
+ + ++D+ND P + V D GT +T + + +DP PA VRY + D
Sbjct: 909 TDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT--FLDASDPDLGPAGEVRYVLMD 966
Query: 899 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS-ATVKILV-- 955
F V+ +G +I L+ E + L + A D G P+ + V+++V
Sbjct: 967 GAH----GTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLD 1022
Query: 956 ----LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007
LHP F + V E + GT V V++A + ++ + Y + +G
Sbjct: 1023 VNENLHPPHFASFVHQ----GQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLA 1078
Query: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
F IN TG+I PLD E + Y L V A D V L S+ +VYIE+ D
Sbjct: 1079 AFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--------SSVTEVYIEVTDA 1130
Query: 1067 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGK--EGF 1124
N++PP + + + EDA + TSVL++ A D D+ + + + I G F
Sbjct: 1131 NDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-----ITSGNYMGFF 1185
Query: 1125 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
++ TGL+ TA + +V D+ L + V+V +++ D I S+
Sbjct: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
Score = 227 bits (579), Expect = 7e-59
Identities = 292/1131 (25%), Positives = 482/1131 (42%), Gaps = 172/1131 (15%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATV----------------NELTPVGTTIFTGFSGD-- 173
+V I VRD ND+ P F + Y + +E + V +I TG + +
Sbjct: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSIKTGNADEAV 1916
Query: 174 -----NGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 228
G+ + + + + D DT + + LT VL K L + D+ Y
Sbjct: 1917 TIHPVTGSISVLNPAFLGLSRKLTIRASDGLYQDTALVKISLTQ--VLDKSLQF-DQDVY 1973
Query: 229 FVIIQANDRAQNLNERRT----------TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC- 277
+ ++ +NL +R+ TL+ +L+G D+ M + V TR
Sbjct: 1974 WAAVK-----ENLQDRKALVILGAQGNHLNDTLSYFLLNGTDMFHM-VQSAGVLQTRGVA 2027
Query: 278 ----RPLTYQAAIP--ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSIL---- 327
+ T++ A+ + RTP+ + +V I +D N PP + Y+I+
Sbjct: 2028 FDREQQDTHELAVEVRDNRTPQRVAQGLVRVSI----EDVNDNPPKFKHLPYYTIIQDGT 2083
Query: 328 ---------------VGT--------PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
+GT EDY +F + P ++SL +P + K+ L
Sbjct: 2084 EPGDVLFQVSATDEDLGTNGAVTYEFAEDY-TYFRIDPYLGDISLKKPFDYQALNKYHLK 2142
Query: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
+ A +D G P + + + N +P F P Y+ + E+ + I + SP
Sbjct: 2143 VIA-RDGGTP-SLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPILHT-QARSPE 2199
Query: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
+ + +E + L LF D+ +TG+ LT+ P+D E + + F++ A
Sbjct: 2200 GLRLIYNIVE---EEPLMLFTTDF-------KTGV---LTVTGPLDYESKTKHVFTVRAT 2246
Query: 485 DGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
D S V + V D NDN PTF ++ Y + + VIQL A D D G N +
Sbjct: 2247 DTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRD 2306
Query: 544 ITYEILVGAQG---DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
++Y+I+ F IN +TG ++ TVQ
Sbjct: 2307 VSYQIVEDGSDVSKFFQINGSTGEMS---------------TVQ---------------- 2335
Query: 601 LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVE 658
LD E+ + + + A D G P T V + V+D+NDN P F P N+S +
Sbjct: 2336 ---ELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSEL- 2391
Query: 659 EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKL-NREVRDYYE 715
V +V+A DPD+ ++ Y + GN + F I S+ I + L + + Y
Sbjct: 2392 ATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYN 2451
Query: 716 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 775
L V A+DG +T+ + I + + SP F Y + EN GT ++ + A D
Sbjct: 2452 LRVGASDGVF---RATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDK 2508
Query: 776 DLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGT 833
D G + Y I + F+++P G+++ L+ LD E E I V A D G
Sbjct: 2509 DSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRE--NSTERVIAIKVMARDGGGR 2565
Query: 834 MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 893
+ TV +I+ D ND PP F Y + + K +P+ V A DAD G A V
Sbjct: 2566 V--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDAD-EGQNAD-VT 2621
Query: 894 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 953
Y V+ + E+ +G V + +L + A D G P +S V++
Sbjct: 2622 YSVNPEDL--VKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRL 2679
Query: 954 LVL-HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSG-----NEED 1007
V+ +P+F++ Y +L +G+ +G++ A A ++YS+V G N++
Sbjct: 2680 QVVPKKVSLPKFSEPLYTFSAPEDL-PEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDG 2738
Query: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
F ++ TGVI V P+D+E+ Y + V A L+ N V S V I++ D N
Sbjct: 2739 VFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQ----NTDVVS---LVSVNIQVGDVN 2791
Query: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1127
++ PVF+ Y ++E+ + TSV++V A DKDTG ++YRL P E F ++
Sbjct: 2792 DNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAID 2851
Query: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGK--GLSGKADVLVSVVNQLD 1176
+ +G I T + F V+A D+G+ LS +A V VS+ ++ D
Sbjct: 2852 SESGWITTLQELDCETCQTYHFHVVAY-DHGQTIQLSSQALVQVSITDEND 2901
Score = 209 bits (531), Expect = 3e-53
Identities = 272/1090 (24%), Positives = 445/1090 (40%), Gaps = 130/1090 (11%)
Query: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
Query: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQINGS-TGEMSTVQELDYEAQQHFHVKVRA 2351
Query: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
Query: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
Query: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
Query: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
Query: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
Query: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
Query: 591 PAERSTGILTLGKALDRESTDRY---ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 647
P S + L + S ++ + +A + P+G+ V V D
Sbjct: 2669 PHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ--------D 2720
Query: 648 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLN 707
P + + E+N V + DPD G+ I ++
Sbjct: 2721 PVIYSLVRGTTPESNK--DGVFSLDPDTGV----------------------IKVRKPMD 2756
Query: 708 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 767
E Y++ V+A S +++ I+V D++DN PVF Y ++ EN+P GT++
Sbjct: 2757 HESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV 2816
Query: 768 LQIEAKDVDLG--ANVSYRIRS---PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 822
+Q+ A D D G VSYR+ + V FA+ +G ++ L+ LD E +
Sbjct: 2817 IQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETC----QTYH 2872
Query: 823 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 881
F V A+D T+ A V V + D ND P F+ Y+G V ++ G + T+ D
Sbjct: 2873 FHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD 2932
Query: 882 ADPPGLPASRVRYRVDDVQFPYPASIFEVEE--DSGRVITRVNLNEEPTTIFKLVVVAFD 939
AD + + R + P F + + D R+ +R L+ E T + L V A
Sbjct: 2933 AD----ISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTA-S 2987
Query: 940 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI----NQ 994
DG+ +S TV+I VL + P+ +Q Y V E G + +SA + N
Sbjct: 2988 DGK--FQASVTVEIFVLDVNDNSPQCSQLLY-TGKVHEDVFPGHFILKVSATDLDTDTNA 3044
Query: 995 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1054
I YS+ G F ++ TG + LD E + D +V +S
Sbjct: 3045 QITYSL-HGPGAHEFKLDPHTGELTTLTALDRERK---------DVFNLVAKATDGGGRS 3094
Query: 1055 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1114
A + + ++D N++ P F V ++ + T V V A D D G + + Y L
Sbjct: 3095 CQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSL-- 3152
Query: 1115 PPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSVVN 1173
P EG F ++ TG+I+ ++ + V A+D LS V VSVV
Sbjct: 3153 PDSAEGH--FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVG 3210
Query: 1174 QLDMQVIVSN 1183
D + N
Sbjct: 3211 LEDYLPVFLN 3220
Score = 196 bits (498), Expect = 2e-49
Identities = 230/904 (25%), Positives = 379/904 (41%), Gaps = 103/904 (11%)
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
TG I +RK +++E Y + + A+ N + ++ + V D +D P+F
Sbjct: 2746 TGVIKVRKPMDHESTKLYQIDVMAHCLQ---NTDVVSLVSVNIQVGDVNDNRPVF----- 2797
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVG 329
+ P Y+A + E P + I VT AID+D + R G + Y +
Sbjct: 2798 -----EADP--YKAVLTE-NMPVGTSVIQVT----AIDKD------TGRDGQVSYRLSAD 2839
Query: 330 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP--LPAFAGLHIEILD 387
+ F + + ++ L+ ++ + Q + + A D+G L + A + + I D
Sbjct: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVA-YDHGQTIQLSSQALVQVSITD 2898
Query: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI-EDTKDPELHLFLN 446
EN+ +P F Y+G ++E++ G ++ + LD DI E + ++
Sbjct: 2899 ENDNAPRFASEEYRGSVVENSEPGELVAT---------LKTLDADISEQNRQVTCYITEG 2949
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
D F ++Q G ++ + +DRE Y +TA DG ++ V V I V+D NDN+
Sbjct: 2950 DPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQAS-VTVEIFVLDVNDNS 3008
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
P ++ Y V+ D+ PG +++++A D D +N +ITY + +F ++ TG +T
Sbjct: 3009 PQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELT 3068
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDG 626
LT ALDRE D + L+ A+DG
Sbjct: 3069 -------------TLT---------------------ALDRERKDVFNLVAKATDGG-GR 3093
Query: 627 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 685
+ A + + V DVNDNAP F P V V A DPD G N QV YSL
Sbjct: 3094 SCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLP 3153
Query: 686 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDD 743
+ F I + G I L + EL V A+D G P + T+ + V+ ++D
Sbjct: 3154 DSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVSVVGLED 3213
Query: 744 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGEL 803
PVF N+ ++V V E+ P GT +LQ+ YR+ S + F L TG L
Sbjct: 3214 YLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRFRLDARTGIL 3273
Query: 804 SLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGM 863
+ SLD+E P SI E + + TV V + D+N++ P F + Y
Sbjct: 3274 YVNASLDFETSPKYFLSI----ECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR 3329
Query: 864 VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 923
V +A+ G I TV A D D P L + + Q + F + G + L
Sbjct: 3330 VLENALVGDVILTVSATDEDGP-LNSDITYSLIGGNQLGH----FTIHPKKGELQVAKAL 3384
Query: 924 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGT 982
+ E + + L + A D G+P + + I V + PRF Q Y V E + G+
Sbjct: 3385 DREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNY-STTVQENSPIGS 3443
Query: 983 MVGVI-----SAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1037
V + + + I GN F + ++ G L + Y L++Q
Sbjct: 3444 KVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEG-LSRRAQEWYQLQIQ 3502
Query: 1038 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
A ++ +P S+ V + + +++++ P V ED V ++ A
Sbjct: 3503 A-------SDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHA 3555
Query: 1098 TDKD 1101
TD+D
Sbjct: 3556 TDRD 3559
Score = 190 bits (483), Expect = 1e-47
Identities = 290/1216 (23%), Positives = 495/1216 (40%), Gaps = 191/1216 (15%)
Query: 2 FRQFYLWTCLA---SGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVD 58
F +Y T LA + L S+ E+ + D A PP A+ S V
Sbjct: 1099 FASYYWLTVLAVDRGSVPLSSVTEVYIEVTD-----ANDNPPQMSQAVFYPSIQEDAPVG 1153
Query: 59 NMLIKGTAGGPDPTIELSLKDNVDY-----WVLMDPVKQMLFLNSTGRVLDRDPPMNIHS 113
+++ A PD + + L N+ + ++ PV +L ST + LDR+ N
Sbjct: 1154 TSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLL---STAQQLDRE---NKDE 1207
Query: 114 IVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFS 171
+++V + N + V + + D NDN P F H+ + + E L+PV G
Sbjct: 1208 HILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSP----GPV 1263
Query: 172 GDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI 231
A+D+D+G NG++ Y I+ + ++ S D ++TG V+ + +
Sbjct: 1264 YRLVASDLDEGLNGRVTYSIEDSDEEAFSID------LVTG--VVSSSSTFTAGEYNILT 1315
Query: 232 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 291
I+A D Q L+ V + P P + PL + T
Sbjct: 1316 IKATDSGQ---------PPLSASVRLHIEWIPWPRPSSI--------PLAFDETYYSF-T 1357
Query: 292 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 351
E +P+ + +++ RPG+ + + G +D F + T + +
Sbjct: 1358 VMETDPVNHMVGVISVE---------GRPGLFWFNISGGDKDMD--FDIEKTTGSIVIAR 1406
Query: 352 PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 411
P++ ++L ++ D + + + I + N+ P F Y+ + + G
Sbjct: 1407 PLDTRRRSNYNLTVEVT-DGSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPG 1464
Query: 412 ATISDSLNLTSPLRIVALDKD--------IEDTKDP-ELHLFLNDYTSVFTVTQTGITRY 462
+ LR+ A+D+D I ++DP LF D +S VT
Sbjct: 1465 VEL---------LRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVT------- 1508
Query: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
+ L Q T T + + + V V I V D N + P F ++ Y+ V +
Sbjct: 1509 VGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTI 1568
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYAL 581
PG ++Q+ A+DAD G N E+ Y +L G ++G F IN G+IT+ A
Sbjct: 1569 APGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITL------------AQ 1616
Query: 582 TVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 640
+ A++AP + L + A D G P ATV I V +
Sbjct: 1617 KLDQANHAP----------------------HTLTVKAEDQGSPQWHDLATVIIHVYPSD 1654
Query: 641 DNAPVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRI 694
+AP+F ++ VE + VG V A P +V Y L GN + +F +
Sbjct: 1655 RSAPIFS----KSEYFVEIPESIPVGSPILLVSAMSPS-----EVTYELREGNKDGVFSM 1705
Query: 695 TS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 753
S +G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 1706 NSYSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTF 1763
Query: 754 TVLVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELS 804
+ E P + I+ I A D D AN + Y+I PE FF + P G L+
Sbjct: 1764 VGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLT 1823
Query: 805 LLRSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKG 862
++ +DYE+ P S F V D + P A V + V+D+ND PP FS++IY+
Sbjct: 1824 IVSEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEV 1879
Query: 863 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922
+ G + V A D D S V Y + +I V +G +
Sbjct: 1880 AIVGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV--- 1927
Query: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP-GEIPRFTQEEYRPPPVSELATKG 981
LN + + + + DG + +A VKI + + +F Q+ Y L +
Sbjct: 1928 LNPAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRK 1985
Query: 982 TMVGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQA 1038
+V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1986 ALV-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE- 2041
Query: 1039 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1098
+ + R P + V + I+D N++PP F+ Y + + + +V AT
Sbjct: 2042 ------VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSAT 2095
Query: 1099 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYG 1158
D+D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 2096 DEDLGTNGAVTYEFA-----EDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGT 2150
Query: 1159 KGLSGKADVLVSVVNQ 1174
L + +VLV+V N+
Sbjct: 2151 PSLQSEEEVLVTVRNK 2166
Score = 186 bits (472), Expect = 2e-46
Identities = 245/1038 (23%), Positives = 421/1038 (40%), Gaps = 135/1038 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V D N + P F Y A+V + GT + A D D G N ++ Y +
Sbjct: 1541 VTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELL-----QVRAMDADRGVNAEVHYSLL 1595
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
S F I +L G I L ++L+ + + + ++A D+ + + T+
Sbjct: 1596 KG----NSEGFFNINALL-GIITLAQKLDQANHAPHTLTVKAEDQG---SPQWHDLATVI 1647
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ V D P+F Y IPE I V PI + +
Sbjct: 1648 IHVYPSDRSAPIFSKS------------EYFVEIPE--------SIPVGSPILLV----S 1683
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
PS+ + Y + G + F M+ + +S + ++ + + L I+ G
Sbjct: 1684 AMSPSE---VTYELREGNKDGV---FSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAG 1737
Query: 373 HPLPAFAGLHI--EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
AF + + +I+DEN+ +P F ++ G I E+AP+ + I D N +P I A D
Sbjct: 1738 ----AFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNN--NPFVIHASD 1791
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---- 486
D E + + F + + T LT++ +D E ++ F + D
Sbjct: 1792 SDKEANSLLVYKILEPEALKFFKIDPSMGT--LTIVSEMDYESMPSFQFCVYVHDQGSPV 1849
Query: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
+ P V I V D ND+ P F E Y+V + + PG ++ + A D D E+ Y
Sbjct: 1850 LFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDS----EVNY 1905
Query: 547 EILVGAQGDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKAL 605
I G + + I+ TG I++ +G + LT++A+D
Sbjct: 1906 SIKTGNADEAVTIHPVTGSISVLNPA--FLGLSRKLTIRASDGLYQ-------------- 1949
Query: 606 DRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 665
TA V I +T V D + FD + + V+E
Sbjct: 1950 ----------------------DTALVKISLTQVLDKSLQFDQDV--YWAAVKENLQDRK 1985
Query: 666 GQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA--VKLNREVRDYYELVVVATDG 723
V +N + Y L N ++F + + + V +RE +D +EL V D
Sbjct: 1986 ALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDN 2045
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSY 783
R + + + + D++DN P F + Y ++++ G + Q+ A D DLG N +
Sbjct: 2046 RTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAV 2105
Query: 784 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 843
E +F + P+ G++SL + DY+A + A D G P + V
Sbjct: 2106 TYEFAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVI----ARD--GGTPSLQSEEEV 2159
Query: 844 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 903
+V N P+F YK V + TPI ++ + P GL R+ Y + + +
Sbjct: 2160 LVTVRNKSNPLFQSPYYKVRVPENITLYTPI--LHTQARSPEGL---RLIYNIVEEE--- 2211
Query: 904 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 962
P +F + +G + L+ E T V A D S ATV++LV + P
Sbjct: 2212 PLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSF-SEATVEVLVEDVNDNPP 2270
Query: 963 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDT--FGINNITGV 1017
F+Q Y L + ++ ++++ + N+ + Y IV + + F IN TG
Sbjct: 2271 TFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGE 2330
Query: 1018 IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKF 1077
+ LDYE + + ++V+A + P + V + + D N++PP F++
Sbjct: 2331 MSTVQELDYEAQQHFHVKVRA-------MDKGDPPLTGETLVVVNVSDINDNPPEFRQPQ 2383
Query: 1078 YIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAM 1137
Y VSE A VL+V+A D D+ + S + Y LI+ ++ F + + +G+I
Sbjct: 2384 YEANVSELATCGHLVLKVQAIDPDSRDTSRLEY-LILSGNQD--RHFFINSSSGIISMFN 2440
Query: 1138 LFHNMRRSYFKFQVIATD 1155
L S + +V A+D
Sbjct: 2441 LCKKHLDSSYNLRVGASD 2458
Score = 182 bits (462), Expect = 3e-45
Identities = 266/1078 (24%), Positives = 434/1078 (40%), Gaps = 182/1078 (16%)
Query: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
Query: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
Query: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
D P F P YQ I E E+ I + D + D
Sbjct: 815 DNAPRFPPG------------GYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
Query: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
Query: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
L I + D N+ SP + + E P G ++ D
Sbjct: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
Query: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
Query: 488 QESEPVIVNIQVMDANDNT--PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
Query: 546 YEILVGAQ-GDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGK 603
Y + G F IN+ TG+I T+AP
Sbjct: 1069 YFLRAGTGLAAFSINQDTGMIQTLAP---------------------------------- 1094
Query: 604 ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-----VFDPYLPRNLSVV 657
LDRE Y L + A D G +S V I VTD NDN P VF P + + V
Sbjct: 1095 -LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPV- 1152
Query: 658 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYY 714
V Q+ A DPD+ G++ +++ GN+ F I G + TA +L+RE +D +
Sbjct: 1153 ----GTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEH 1208
Query: 715 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP--AGTTILQIEA 772
L V D ST + + +LD++DN P+F++ + V + E L + + ++ A
Sbjct: 1209 ILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVA 1268
Query: 773 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 830
D+D G N V+Y I + + F++ TG +S F E +I ++A D
Sbjct: 1269 SDLDEGLNGRVTYSIEDSD-EEAFSIDLVTGVVS-----SSSTFTAGEYNI-LTIKATD- 1320
Query: 831 YGTMPPGIATVTVIVKDM-----NDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 885
PP A+V + ++ + + P F + Y V + + E P
Sbjct: 1321 -SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR--P 1377
Query: 886 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 945
GL + D+ F++E+ +G ++ L+ + + L V DG +
Sbjct: 1378 GLFWFNISGGDKDMD-------FDIEKTTGSIVIARPLDTRRRSNYNL-TVEVTDGSRTI 1429
Query: 946 SSSATVKILVLHPGEIPRF--TQEEYRPPPVSELATKGTMVGV--ISAAAINQ----SIV 997
++ + ++ P+F T+ E R P + T+ GV + AI+Q S++
Sbjct: 1430 ATQVHIFMIANINHHRPQFLETRYEVRVP-------QDTVPGVELLRVQAIDQDKGKSLI 1482
Query: 998 YSIVSGNEEDT---FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1054
Y+I + + F ++ +GV+ G LD + S +L V++ + +P K
Sbjct: 1483 YTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS------QHTLTVMVRDQEIPIKR 1536
Query: 1055 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1114
N V I ++D N HPP F + Y V + T +L+V+A D D G + + Y L
Sbjct: 1537 NFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSL-- 1594
Query: 1115 PPIKEGKEGFV-VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1171
+K EGF + G+I A + V A D A V++ V
Sbjct: 1595 --LKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHV 1650
Score = 177 bits (449), Expect = 9e-44
Identities = 223/867 (25%), Positives = 337/867 (38%), Gaps = 161/867 (18%)
Query: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
Query: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
Query: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
Query: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
P EL + T +Q+R + L + D R +S
Sbjct: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
Query: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
Query: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
G I L++ A D D + P H F D TG
Sbjct: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
Query: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM--------- 573
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++
Sbjct: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
Query: 574 ---------------------IVGRTYAL--------TVQAADNAPP------------- 591
+VG L +VQ ++APP
Sbjct: 3187 VRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRP 3246
Query: 592 -AERS------------------TGILTLGKALDRESTDRYILIITASDGRPDGTS-TAT 631
AE++ TGIL + +LD E++ +Y L I S S T
Sbjct: 3247 GAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTT 3306
Query: 632 VNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQV----KATDPDAGINGQVHYSL 685
V + +TDVN++ P F DPY R L NA VG V ATD D +N + YSL
Sbjct: 3307 VMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITYSL 3360
Query: 686 GNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
N L T G + A L+RE Y L + ATD P H +AI+V D++
Sbjct: 3361 IGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVN 3420
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHPF 799
DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F + P
Sbjct: 3421 DNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTP- 3479
Query: 800 TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSK 857
G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 3480 DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSALP 3533
Query: 858 RIYKGMVAPDAVKGTPITTVYAEDADP 884
V D +G + ++A D DP
Sbjct: 3534 LEIFITVGEDEFQGGMVGKIHATDRDP 3560
Score = 153 bits (386), Expect = 2e-36
Identities = 251/1137 (22%), Positives = 427/1137 (37%), Gaps = 191/1137 (16%)
Query: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
Query: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
Query: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
A DR + ++E G+ G + V V P LR P
Sbjct: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
Query: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
Query: 346 ELSL--LEPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
E SL ++ +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
Query: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP---ELHLFLNDYTSVFTVTQTG 458
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 369 VQLSEFSPPGSRV-------VMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
Query: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
+D ++ Y I G +V I ++D N++ P F SYD +
Sbjct: 421 ----------MDFHDRAHYQLHIRTSPG---QASTVVVIDIVDCNNHAPLFNRSSYDGTL 467
Query: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
Query: 578 TYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 637
Y V+A+D P R + ++ + +
Sbjct: 528 IYTFRVRASDWGSPFRREKEV--------------------------------SIFLQLR 555
Query: 638 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 697
++NDN P+F+ + + + A D D N + GN F +
Sbjct: 556 NLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHF 615
Query: 698 GSIYTA----VKLNREVRDYYELVVVATDGAVHPRHSTLTLAI------KVLDIDDNSPV 747
+ + + L Y L + A+DG + +TL + + +V D + V
Sbjct: 616 SGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGV 675
Query: 748 FTNSTYTVL---------------------------------------VEENLPAGTTIL 768
T T T+L V E++P T +
Sbjct: 676 LTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLA 735
Query: 769 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826
++ A D D G N + Y I + F + TG L++ LDYEA ++T
Sbjct: 736 RLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVT---- 791
Query: 827 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 886
+D+ +TV VKD ND P F Y+ ++ D GT I + +DAD
Sbjct: 792 VYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSE- 850
Query: 887 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---GEP 943
RVRY + P F + +G ++ +L+ E + L V A D G
Sbjct: 851 -DNGRVRYTLLS-----PTEKFSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQ 904
Query: 944 VMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYS 999
+ S + + L P+ E R V E GT++ + A+ + + Y
Sbjct: 905 LFSVTDLIITLEDVNDNSPQCITEHNR-LKVPEDLPPGTVLTFLDASDPDLGPAGEVRYV 963
Query: 1000 IVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKV 1059
++ G TF ++ +TG + + LD+E R Y L + A LA + +V
Sbjct: 964 LMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCH----VEV 1018
Query: 1060 YIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKE 1119
+ +EN HPP F + G V E++ T V+ V A D D+G + Y L
Sbjct: 1019 IVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFL---RAGT 1075
Query: 1120 GKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
G F + TG+I+T SY+ V+A D LS +V + V + D
Sbjct: 1076 GLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDAND 1132
Score = 136 bits (342), Expect = 2e-31
Identities = 205/939 (21%), Positives = 372/939 (39%), Gaps = 195/939 (20%)
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
F + +++ +LL NR+ + L+I+A + L A + + ILD+N+ P F+
Sbjct: 94 FLRIRTKSSNTALL---NREVRDSYTLIIQATEKTLE-LEALTRVVVHILDQNDLKPLFS 149
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFLNDYTSVFTVT 455
PSY+ TIS+ + L SP+ ++ A D D+ ++ E + N + +F +
Sbjct: 150 PPSYR----------VTISEDMPLKSPICKVTATDADL--GQNAEFYYAFNTRSEMFAIH 197
Query: 456 QT-GITRYLTLLQPVDREEQQTYTFSITAFDGVQESE-------------------PVIV 495
T G+ L R + + ++ + E P I
Sbjct: 198 PTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIA 257
Query: 496 NIQVM--DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
++ V D+ND T +Y + G V + V D G + + A
Sbjct: 258 SVVVTPPDSNDGT------TYATVLVDANSSGAEVESVEVVGGDPGKHFK--------AI 303
Query: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP--AERSTGILTLGKALDRESTD 611
+ + L+++ M + L++QA + P + G L +
Sbjct: 304 KSYARSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFE 363
Query: 612 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT 671
+ + + S+ P G+ V + P F NL V + ++ VG
Sbjct: 364 KAVYRVQLSEFSPPGSRVVMVRV--------TPAFP-----NLQYVLKPSSENVG----- 405
Query: 672 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHS 730
F++ + + T KL + R +Y+L + P +
Sbjct: 406 --------------------FKLNARTGLITTTKLMDFHDRAHYQLHI-----RTSPGQA 440
Query: 731 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 788
+ + I ++D ++++P+F S+Y ++EN+P GT++L + A D D G N V+Y I P
Sbjct: 441 STVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIAGP 500
Query: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI--VK 846
+ F++ P+ G +S + +DYE + TF V A D +G+ V++ ++
Sbjct: 501 KALP-FSIDPYLGIISTSKPMDYEL---MKRIYTFRVRASD-WGSPFRREKEVSIFLQLR 555
Query: 847 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY 903
++ND P+F + G + D G I T+ A D D ++Y + +++++
Sbjct: 556 NLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD----ELQNLKYEIVSGNELEY-- 609
Query: 904 PASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL---- 956
F++ SG + + +NL T + L + A D +S T+ I V+
Sbjct: 610 ----FDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKN--YASPTTLNITVVKDPH 663
Query: 957 --------HPGEIPRFTQ---------------------------------EEYRPPPVS 975
G + +FT+ E++ P +
Sbjct: 664 FEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSID 723
Query: 976 ELATK--GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETR 1029
L + T + ++A A N +VY I GNEE F I TG++ V PLDYE
Sbjct: 724 VLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEAT 783
Query: 1030 TSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMF 1089
Y+ L V + +L P KS+ + + ++D N++ P F Y +SED +
Sbjct: 784 NFYI-------LNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVG 836
Query: 1090 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFK 1148
T++ + D D+ + + Y L+ P E F + TG L+ T L Y
Sbjct: 837 TTIAELTTKDADSEDNGRVRYTLLSP-----TEKFSLHPLTGELVVTGHLDRESEPRYI- 890
Query: 1149 FQVIATDDYGKG--LSGKADVLVSV--VNQLDMQVIVSN 1183
+V A D KG L D+++++ VN Q I +
Sbjct: 891 LKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEH 929
Score = 134 bits (338), Expect = 6e-31
Identities = 167/676 (24%), Positives = 264/676 (39%), Gaps = 109/676 (16%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG-FSGDNGATDIDDGPNGQIEYVI 191
V I V D NDNSP Y V+E +F G F ATD+D N QI Y +
Sbjct: 2997 VEIFVLDVNDNSPQCSQLLYTGKVHE------DVFPGHFILKVSATDLDTDTNAQITYSL 3050
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
P +++ P TG + L+ E K + ++ +A D R+ +
Sbjct: 3051 H----GPGAHEFKLDPH--TGELTTLTALDRERKDVFNLVAKATDGGG-----RSCQADI 3099
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
T+ V D +D P F P D + A+ R P DQ
Sbjct: 3100 TLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDP---------------DQGA 3144
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
N Q ++YS+ P+ F + T + L +P+ +L ++A D
Sbjct: 3145 NAQ-------VVYSL----PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRAS-DL 3192
Query: 372 GHPLP--AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
G P+P + + ++ + P F + + E AP G + LT P
Sbjct: 3193 GTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEKTG 3252
Query: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF--DGV 487
+ + + L +TGI L + +D E Y SI
Sbjct: 3253 YRVVSGNEQGRFRLD----------ARTGI---LYVNASLDFETSPKYFLSIECSRKSSS 3299
Query: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
S+ V + + D N++ P FP+ Y V + GD ++ ++A D D N +ITY
Sbjct: 3300 SLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYS 3359
Query: 548 ILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
++ G Q G TI P G L + KALDR
Sbjct: 3360 LIGGNQ--------LGHFTIHP-------------------------KKGELQVAKALDR 3386
Query: 608 ESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG 666
E Y L + A+D G+P + I V DVNDN P F N S +E N+ +G
Sbjct: 3387 EQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---FQLNYSTTVQE-NSPIG 3442
Query: 667 ----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 719
Q+ +DPD+ NG + + GN + FR+T +G + TA L+R +++Y+L +
Sbjct: 3443 SKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQ 3502
Query: 720 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 779
A+D + P S ++ + V + +P + V E+ G + +I A D D
Sbjct: 3503 ASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD 3562
Query: 780 NVSYRIRSPEV--KHF 793
++Y + E +HF
Sbjct: 3563 TLTYSLAEEETLGRHF 3578
Score = 127 bits (319), Expect = 1e-28
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 683 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
Query: 803 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 861
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
Query: 862 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 921
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
Query: 922 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 978
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
Query: 979 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
Query: 1039 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1098
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
Query: 1099 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1155
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
Score = 103 bits (258), Expect = 1e-21
Identities = 174/781 (22%), Positives = 297/781 (38%), Gaps = 102/781 (13%)
Query: 469 VDREEQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
++RE + +YT I A + E E + V + ++D ND P F SY V + DM
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSP 166
Query: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
+ ++TA DAD G N E Y ++ F I+ T+G++T+A + + + L V A D
Sbjct: 167 ICKVTATDADLGQNAEFYYAFNTRSE-MFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVD 225
Query: 588 NAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 647
G +L L++ + A+V + D ND
Sbjct: 226 RMRKISEGNGFGSLA-----------ALVVHVEPALRKPPAIASVVVTPPDSNDGTTYAT 274
Query: 648 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLN 707
+ N S E E+ VG DP Y+ N S+ + +N
Sbjct: 275 VLVDANSSGAEVESVEVVG----GDPGKHFKAIKSYARSN---------EFSLVSVKDIN 321
Query: 708 -REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766
E + L + A G+ P + + +S F + Y V + E P G+
Sbjct: 322 WMEYLHGFNLSLQARSGS-GPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSR 380
Query: 767 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826
++ + N+ Y ++ F L+ TG ++ + +D+ + I
Sbjct: 381 VVMVRV--TPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIR---- 434
Query: 827 AFDIYGTMPPGIATVTVI-VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 885
T P +TV VI + D N++ P+F++ Y G + + GT + V A D D
Sbjct: 435 ------TSPGQASTVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRD-- 486
Query: 886 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE-PTTIFKLVVVAFDDGEPV 944
Y + P A F ++ G + T ++ E I+ V A D G P
Sbjct: 487 ---HGENGYVTYSIAGP-KALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF 542
Query: 945 -MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN--QSIVYSIV 1001
++ + + + + +E + + G + +SA ++ Q++ Y IV
Sbjct: 543 RREKEVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIV 602
Query: 1002 SGNEEDTFGINNITGVIYVNGP---LDYETRTSYVLRVQAD---------SLEVVLA--- 1046
SGNE + F +N+ +GVI + P L TSY L++ A +L + +
Sbjct: 603 SGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDP 662
Query: 1047 NLRVPSKSNTAKV----------YIEIQDE---------------NNHPPVFQKKFYIG- 1080
+ VP + V +I +Q++ N++ P F+ F
Sbjct: 663 HFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSI 722
Query: 1081 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAML 1138
V E + T + R+ ATD D G + Y I +G E F +E TGL+ A
Sbjct: 723 DVLESVPINTPLARLAATDPDAGFNGKLVY-----VIADGNEEGCFDIELETGLLTVAAP 777
Query: 1139 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTE 1198
+++ V Y G K+ + VN D PP + I + TE
Sbjct: 778 LDYEATNFYILNVTV---YDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTE 834
Query: 1199 I 1199
+
Sbjct: 835 V 835
Score = 32.0 bits (71), Expect = 5.9
Identities = 18/48 (37%), Positives = 26/48 (54%), Gaps = 4/48 (8%)
Query: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLP 267
LN E + Y +IIQA ++ L T + V +LD +DL P+F P
Sbjct: 107 LNREVRDSYTLIIQATEKTLELE----ALTRVVVHILDQNDLKPLFSP 150
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 251 bits (640), Expect = 6e-66
Identities = 266/951 (27%), Positives = 419/951 (44%), Gaps = 120/951 (12%)
Query: 147 FKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI 206
F +Y + E P GT I A +G ++ Y ++ D S F I
Sbjct: 245 FPMPNYQVALFENEPAGTLIL-----QLHAHYTIEGEEERVSYYME-GLFDERSRGYFRI 298
Query: 207 PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFL 266
TG + L+ E K + + ++A D + R+ TT +TV V D +D P+F
Sbjct: 299 D-SATGAVSTDSVLDRETKETHVLRVKAVDYS---TPPRSATTYITVLVKDTNDHSPVFE 354
Query: 267 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 326
R+ + Y+ I+A D+D I + Y +
Sbjct: 355 QSEYRERVRENLEVGYEVLT-----------------IRASDRDSPINA-----NLRYRV 392
Query: 327 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD--NGHPLPAFAGLHIE 384
L G + F ++ + +S ++R+ ++ L+++A N PL A A ++IE
Sbjct: 393 LGGAWD----VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIE 448
Query: 385 ILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL-TSPLRIVALDKDIEDTKDPELHL 443
+ DEN+ P F S Q Y+++ + + + L T+ LR+ A D+D +
Sbjct: 449 VEDENDNYPQF---SEQNYVVQ-------VPEDVGLNTAVLRVQATDRDQGQNAAIHYSI 498
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE---SEPVIVNIQVM 500
+ F + ++ L ++ P+D E+ Q Y+ SI A DG + + +V++QV+
Sbjct: 499 LSGNVAGQFYLHS--LSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVL 556
Query: 501 DANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINK 560
D NDN P F + V ++ G V+ + AVDAD G N + Y LV F+
Sbjct: 557 DVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYR-LVDTASTFLGGG 615
Query: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITAS 620
+ G AP D S+G +T+ LDRE + Y + A
Sbjct: 616 SAGPKNPAP---------------TPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV 660
Query: 621 D-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGI 677
D G P +S+ +V+I V DVNDN PVF P + E+A + V ++A D DA
Sbjct: 661 DHGSPPMSSSTSVSITVLDVNDNDPVFTQ--PTYELRLNEDAAVGSSVLTLQARDRDA-- 716
Query: 678 NGQVHYSL--GNFNNLFRITSN---GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL 732
N + Y L GN N F ++S G I A+ L+ + Y L V A+DG R T
Sbjct: 717 NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT---RSHTA 773
Query: 733 TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEV 790
+ I V D + + PVF +S YTV V E+ P GT+I + A D D G N ++Y I+ P
Sbjct: 774 HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP 833
Query: 791 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 850
+ F + P +G + + LDYE + + T + A D T+ +++ D ND
Sbjct: 834 Q--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDNGIPQKSDTTTLEILILDAND 887
Query: 851 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPYPASI 907
P F Y+G + DA T I V A D D P R+ Y DD
Sbjct: 888 NAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNGRLLYTFQGGDDGD-----GD 940
Query: 908 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFT 965
F +E SG + T+ L+ E ++ L +A D G P +S+S +++ +L + P F
Sbjct: 941 FYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE 1000
Query: 966 QEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVN 1021
++E V E G++V I A N I+Y IV G+ F ++ + G +
Sbjct: 1001 KDELELF-VEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAM 1059
Query: 1022 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1072
LD+E R YVL VQA S +V + A V+I + D+N++PPV
Sbjct: 1060 VELDFEVRREYVLVVQATSAPLV----------SRATVHILLVDQNDNPPV 1100
Score = 232 bits (591), Expect = 3e-60
Identities = 232/880 (26%), Positives = 395/880 (44%), Gaps = 118/880 (13%)
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
+F + T +S ++R+ + L +KA + P A + + + D N+ SP F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Y+ + E+ VG + L I A D+D + + L VF + +
Sbjct: 355 QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
Query: 457 -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511
+G+ +L DREE Y + A D + P+ V I+V D NDN P F E
Sbjct: 405 SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
Query: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570
+Y V V D+ +V+++ A D D+G N I Y IL G G F ++ +G++ +
Sbjct: 462 QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
Query: 571 VEMIVGRTYALTVQAADNA-PPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTST 629
++ + Y+L+++A D PP S+G+
Sbjct: 522 LDFEDVQKYSLSIKAQDGGRPPLINSSGV------------------------------- 550
Query: 630 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLGNF 688
V++ V DVNDN P+F P +V+E + V ++A D D+G N ++HY L +
Sbjct: 551 --VSVQVLDVNDNEPIF-VSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDT 607
Query: 689 NNLFR--------------------ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 728
+ F S+G I +L+RE ++Y V A D P
Sbjct: 608 ASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPM 667
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSP 788
S+ +++I VLD++DN PVFT TY + + E+ G+++L ++A+D D + ++Y++
Sbjct: 668 SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGG 727
Query: 789 EVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK 846
++ FAL G ++L LDY+ QE V A D GT A V + V
Sbjct: 728 NTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GTR-SHTAHVLINVT 780
Query: 847 DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPAS 906
D N + PVF Y V+ D GT I T+ A D D +R+ Y + D P
Sbjct: 781 DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARITYVIQD-----PVP 833
Query: 907 IFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFT 965
F ++ DSG + T + L+ E + L ++A D+G P S + T++IL+L + P+F
Sbjct: 834 QFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFL 893
Query: 966 QEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TFGINNITGVIYV 1020
+ Y+ + E A T + +SA + N ++Y+ G++ D F I +GVI
Sbjct: 894 WDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRT 952
Query: 1021 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYI 1079
LD E Y +L + + P+ S + ++ + I D N++ P+F+K
Sbjct: 953 QRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELE 1005
Query: 1080 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGFVVETYTGLIKTAM 1137
V E+ + + V +++A D D G + + Y+++ EG + F ++ G ++ +
Sbjct: 1006 LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFFQLDLLNGDLRAMV 1060
Query: 1138 -LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
L +RR Y V+ L +A V + +V+Q D
Sbjct: 1061 ELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
Score = 231 bits (590), Expect = 4e-60
Identities = 256/984 (26%), Positives = 426/984 (43%), Gaps = 135/984 (13%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST VLDR+ V V Y + ++V+D ND+SP F+ Y V
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E VG + T A+D D N + Y + + D F++ +G + R
Sbjct: 364 ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+ E+ Y ++++AND+ +N + T T+ ++V D +D P F V
Sbjct: 413 AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
++ PE++ +QA D+D+ I YSIL G
Sbjct: 466 -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396
F++H + L ++ P++ + QK+ L IKA+ PL +G + +++LD N+ P F
Sbjct: 507 FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
+Q +LE+ P+G + + I A+D D ++ LH L D S F
Sbjct: 567 SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
Query: 457 T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497
+ + ++T+ +DREE + Y+F + A D S V+I
Sbjct: 616 SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
Query: 498 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI 557
V+D NDN P F + +Y++ + D G SV+ L A D D +N ITY++ G
Sbjct: 676 TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGN----- 728
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILII 617
+AL+ Q R G++TL LD + +Y+L +
Sbjct: 729 -----------------TRNRFALSSQ---------RGGGLITLALPLDYKQEQQYVLAV 762
Query: 618 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAG 676
TASDG T+ +N VTD N + PVF +SV E+ + + A D D G
Sbjct: 763 TASDGTRSHTAHVLIN--VTDANTHRPVFQS-SHYTVSVSEDRPVGTSIATLSANDEDTG 819
Query: 677 INGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 735
N ++ Y + + FRI +G++YT ++L+ E + Y L ++A D + + T TL
Sbjct: 820 ENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLE 879
Query: 736 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR-SPEVKH 792
I +LD +DN+P F Y + E+ P T+ILQ+ A D D G N + Y + +
Sbjct: 880 ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 793 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDY 851
F + P +G + R LD E A A D P + + V + D+ND
Sbjct: 940 DFYIEPTSGVIRTQRRLDRE----NVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDN 995
Query: 852 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 911
P+F K + V + G+ + + A D D P +++ Y++ + + F+++
Sbjct: 996 APMFEKDELELFVEENNPVGSVVAKIRANDPDEG--PNAQIMYQIVEGDMRH---FFQLD 1050
Query: 912 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL----HPGEIPRF--T 965
+G + V L+ E + LVV A P++ S ATV IL++ +P +P F
Sbjct: 1051 LLNGDLRAMVELDFEVRREYVLVVQA--TSAPLV-SRATVHILLVDQNDNPPVLPDFQIL 1107
Query: 966 QEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1023
Y + T ++G I A ++ S+ Y+ V GNE ++ TG + ++
Sbjct: 1108 FNNYVTNKSNSFPT--GVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRD 1165
Query: 1024 LDYETRTSYVLRVQ-ADSLEVVLA 1046
LD ++ V +D + V A
Sbjct: 1166 LDNNRPLEALMEVSVSDGIHSVTA 1189
Score = 218 bits (555), Expect = 4e-56
Identities = 229/859 (26%), Positives = 367/859 (42%), Gaps = 120/859 (13%)
Query: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
F MP+YQ + E+ P G I L L + I ++ + + Y + +
Sbjct: 245 FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512
T T + +DRE ++T+ + A D S + + V D ND++P F +
Sbjct: 302 TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572
Y V ++ G V+ + A D D N + Y +L GA F +N+++G+++
Sbjct: 357 EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTR---- 412
Query: 573 MIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDG--TST 629
LDRE Y L++ A+D GR G ++T
Sbjct: 413 ------------------------------AVLDREEAAEYQLLVEANDQGRNPGPLSAT 442
Query: 630 ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSL- 685
ATV I V D NDN P F +N V E N V +V+ATD D G N +HYS+
Sbjct: 443 ATVYIEVEDENDNYPQFS---EQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSIL 499
Query: 686 -GNFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPR-HSTLTLAIKVLDID 742
GN F + S I + L+ E Y L + A DG P +S+ ++++VLD++
Sbjct: 500 SGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVN 559
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIR---------------- 786
DN P+F +S + V EN+P G ++ I+A D D G N R
Sbjct: 560 DNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGP 619
Query: 787 ---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VT 842
+P F +H +G +++ LD E + +F VEA D +G+ P +T V+
Sbjct: 620 KNPAPTPDFPFQIHNSSGWITVCAELDRE----EVEHYSFGVEAVD-HGSPPMSSSTSVS 674
Query: 843 VIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP 902
+ V D+ND PVF++ Y+ + DA G+ + T+ A D D + ++ +F
Sbjct: 675 ITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFA 734
Query: 903 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP 962
+ + G + + L+ + + L V A D S +A V I V
Sbjct: 735 LSS-----QRGGGLITLALPLDYKQEQQYVLAVTASDG---TRSHTAHVLINVTDANTHR 786
Query: 963 RFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVI 1018
Q + VSE GT + +SA N I Y V + F I+ +G +
Sbjct: 787 PVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY--VIQDPVPQFRIDPDSGTM 844
Query: 1019 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1078
Y LDYE + +Y L + A + +P KS+T + I I D N++ P F FY
Sbjct: 845 YTMMELDYENQVAYTLTIMAQ-------DNGIPQKSDTTTLEILILDANDNAPQFLWDFY 897
Query: 1079 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1138
G + EDA TS+L+V ATD+D+G + Y +G F +E +G+I+T
Sbjct: 898 QGSIFEDAPPSTSILQVSATDRDSGPNGRLLY--TFQGGDDGDGDFYIEPTSGVIRTQRR 955
Query: 1139 FHNMRRSYFKFQVIATD-DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLT 1197
+ + +A D LS ++ V++++ I N P + EK
Sbjct: 956 LDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILD------INDNAP--MFEK------ 1001
Query: 1198 EILDRYVQEQIPGAKVVVE 1216
+ L+ +V+E P VV +
Sbjct: 1002 DELELFVEENNPVGSVVAK 1020
Score = 180 bits (456), Expect = 1e-44
Identities = 216/808 (26%), Positives = 332/808 (41%), Gaps = 139/808 (17%)
Query: 81 VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVG---TIIYHE--VRI 135
+ Y +L V +L+S +LD P++ + I + G +I V +
Sbjct: 494 IHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSV 553
Query: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI---- 191
V D NDN P F + ATV E P+G + A D D G N ++ Y +
Sbjct: 554 QVLDVNDNEPIFVSSPFQATVLENVPLGYPVV-----HIQAVDADSGENARLHYRLVDTA 608
Query: 192 -------QYNPDDPTSNDTFEIPLM-LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 243
P +P F + +G I + L+ E+ Y ++A D +
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHG---SP 665
Query: 244 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 303
+++T++++ VLD +D P+F +P TY ELR E+
Sbjct: 666 PMSSSTSVSITVLDVNDNDPVFT-----------QP-TY-----ELRLNEDAAVGSSVLT 708
Query: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAEL-SLLEPVNRDFHQKFD 362
+QA D+D N I Y + G + RF R L +L P++ Q++
Sbjct: 709 LQARDRDANSV-------ITYQLTGGNTRN--RFALSSQRGGGLITLALPLDYKQEQQYV 759
Query: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
L + A A + I + D N P F Y + E PVG +I+
Sbjct: 760 LAVTASDGTRSHT---AHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIA------- 809
Query: 423 PLRIVALDKDIEDT-KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 481
L + EDT ++ + + D F + T Y + +D E Q YT +I
Sbjct: 810 -----TLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYT--MMELDYENQVAYTLTI 862
Query: 482 TAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
A D Q+S+ + I ++DANDN P F Y ++ D P S++Q++A D D G
Sbjct: 863 MAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG 922
Query: 540 SNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTG 597
NG + Y G GDF I T+G+I RT
Sbjct: 923 PNGRLLYTFQGGDDGDGDFYIEPTSGVI-----------RTQ------------------ 953
Query: 598 ILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLS 655
+ LDRE+ Y L A D G P S + + + + D+NDNAP+F+ L
Sbjct: 954 -----RRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELE 1005
Query: 656 VVEEEAN---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNRE 709
+ EE N + V +++A DPD G N Q+ Y + G+ + F++ NG + V+L+ E
Sbjct: 1006 LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFE 1065
Query: 710 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAG 764
VR Y LVV AT P S T+ I ++D +DN PV + + Y + P G
Sbjct: 1066 VRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 765 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEAS 820
I I A D D+ +++Y L P TGEL L R LD EA E S
Sbjct: 1123 -VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVS 1179
Query: 821 ITFLVEAFDIYGTMPPGIATVTVIVKDM 848
++ + + + T+ VT+I DM
Sbjct: 1180 VSDGIHSVTAFCTL-----RVTIITDDM 1202
Score = 119 bits (298), Expect = 3e-26
Identities = 156/635 (24%), Positives = 254/635 (40%), Gaps = 117/635 (18%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V D NDN P F +Y +NE VG+++ T + D A VI
Sbjct: 673 VSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANS-----------VIT 721
Query: 193 YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Y + + F + G ++ L L+Y+ + +Y + + A+D R+ T +
Sbjct: 722 YQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT------RSHTAHV 775
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
++V D + P+F + + RP+ A + A D+D
Sbjct: 776 LINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT-----------------LSANDEDT 818
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ I Y I P+ F + P + + + ++ + + L I A QDN
Sbjct: 819 G-----ENARITYVIQDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTLTIMA-QDN 867
Query: 372 GHPLPA-FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
G P + L I ILD N+ +P F YQG I E AP TS L++ A D
Sbjct: 868 GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPS---------TSILQVSATD 918
Query: 431 KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFDGV 487
+D L+ F +D F + T G+ R L DRE Y A D
Sbjct: 919 RD-SGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRL---DRENVAVYNLWALAVDRG 974
Query: 488 QE---SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
S V + + ++D NDN P F + +++V + G V ++ A D DEG N +I
Sbjct: 975 SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQI 1034
Query: 545 TYEILVGAQGDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGK 603
Y+I+ G F ++ G + ++ V R Y L VQA +AP R
Sbjct: 1035 MYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQAT-SAPLVSR--------- 1084
Query: 604 ALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 663
ATV+I++ D NDN PV + + V ++N+
Sbjct: 1085 --------------------------ATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNS 1118
Query: 664 F----VGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREV---RDYYEL 716
F +G + A DPD ++ ++Y+ N L R+ ++L+R++ R L
Sbjct: 1119 FPTGVIGCIPAHDPD--VSDSLNYTFVQGNEL-RLLLLDPATGELQLSRDLDNNRPLEAL 1175
Query: 717 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 751
+ V+ +H + TL + ++ D + TNS
Sbjct: 1176 MEVSVSDGIHSVTAFCTLRVTIITDD----MLTNS 1206
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 248 bits (633), Expect = 4e-65
Identities = 278/1038 (26%), Positives = 439/1038 (42%), Gaps = 139/1038 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
VR+ + ++N++SP + + V E P GT++ F ATD D GPNG++ Y +Q
Sbjct: 1091 VRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVF-----ATDRDSGPNGRLTYSLQ 1145
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+D + F I TG + + L+ E ++ Y +++Q D + R+TT T+
Sbjct: 1146 QLSED---SKAFRIHPQ-TGEVTTLQTLDREQQSSYQLLVQVQDGG---SPPRSTTGTVH 1198
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
V VLD +D P FL +P ++ P+ + P + +QA D D
Sbjct: 1199 VAVLDLNDNSPTFLQASGAAG----------GGLP-IQVPDRVPPGTLVTTLQAKDPDEG 1247
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ ILY++ E F +HP + EL P+ R + L + A
Sbjct: 1248 -----ENGTILYTLTGPGSE----LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGS 1298
Query: 373 HPLPAFAGLHIEIL----------DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
P A L +++L D + P +P ++ S+
Sbjct: 1299 PPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE 1358
Query: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
P + AL + DPE T + L L +P+D E +
Sbjct: 1359 PAGVGALTYTLVGGADPE-----------GTFALDAASGRLYLARPLDFEAGPPWRALTV 1407
Query: 483 AFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD-EG 539
+G + + V +QV D N++ P F + + + PG ++ A DAD G
Sbjct: 1408 RAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPG 1467
Query: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
N ++ Y +L P V AL + A TG L
Sbjct: 1468 PNSDVRYRLL----------------RQEPPVP-------ALRLDAR---------TGAL 1495
Query: 600 TLGKALDRESTDRYILIITASDGRPDGTST-----ATVNIVVTDVNDNAPVFDPYLPRNL 654
+ + LDRE+T +L++ A+D RP S + + VTD NDNAPVF P +
Sbjct: 1496 SAPRGLDRETTPALLLLVEATD-RPANASRRRAARVSARVFVTDENDNAPVFAS--PSRV 1552
Query: 655 SVVEEEANAFVG-QVKATDPDAGINGQVHYSLGNFNN-LFRI-TSNGSIYTAVKLNREVR 711
+ E++ V A DPD G +V Y L + + FR+ +S G++ L+RE R
Sbjct: 1553 RLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRPLDREQR 1612
Query: 712 DYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIE 771
+ L VVA+D PR +T L + V D++D +P F Y+VL+ EN P GT++L +
Sbjct: 1613 AEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLR 1672
Query: 772 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 829
A D D+GAN V+Y S E F+L P TG L+ LR+LD E ++ I V A D
Sbjct: 1673 ATDPDVGANGQVTYGGVSSE---SFSLDPDTGVLTTLRALDRE----EQEEINLTVYAQD 1725
Query: 830 IYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 887
PP + TV V V+D ND+ P F + + P+ +T + A D D
Sbjct: 1726 --RGSPPQLTHVTVRVAVEDENDHAPTFGS-AHLSLEVPEGQDPQTLTMLRASDPDVGA- 1781
Query: 888 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS 947
+++YR+ D P+ F ++ SG T L+ E F+L + A D G+P +S+
Sbjct: 1782 -NGQLQYRILDGD---PSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSA 1837
Query: 948 SATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVS 1002
+ + + VL + P F Y V E GT++ + A A N + Y + +
Sbjct: 1838 TLLLTVTVLDANDHAPAFPVPAY-SVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGA 1896
Query: 1003 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1062
G F + +G + LD E SY V A + S T V I
Sbjct: 1897 GT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSA------VDGAAAGPLSTTVSVTIT 1949
Query: 1063 IQDENNHPPVFQKKFYIGGVSEDARMFT----SVLRVKATDKDTGNYSVMAYRLIIPPIK 1118
++D N+H P F + F+ ++ ++A D+D G + + YRL P
Sbjct: 1950 VRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTP-- 2007
Query: 1119 EGKEGFVVETYTGLIKTA 1136
G V++YTG I+ A
Sbjct: 2008 --PPGTTVDSYTGEIRVA 2023
Score = 221 bits (563), Expect = 5e-57
Identities = 301/1129 (26%), Positives = 454/1129 (40%), Gaps = 190/1129 (16%)
Query: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
PA V + E+ GT+L+ AG +V Y++ L S+
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGA---------NGHVTYYLGAGTAGAFLLEPSS 1908
Query: 100 GRV-----LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
G + LDR+ P S+ + T + V I VRD ND++PTF
Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLR 1966
Query: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 213
+ P +T + A D D G N I Y + P T+ D++ TG
Sbjct: 1967 LRLPRPGPSFSTPTLALATLR-AEDRDAGANASILYRLAGTPPPGTTVDSY------TGE 2019
Query: 214 I-VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD-DLGPMFLPCVLV 271
I V R + + R I+ A +L + T + + L G+ + GP F
Sbjct: 2020 IRVARSPVALGPRDRVLFIV-----ATDLGRPARSATGVIIVGLQGEAERGPRF------ 2068
Query: 272 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 331
P +A I E PP I R + I YSIL G
Sbjct: 2069 PRASS------EATIREN-----------APPGTPIVSPRAVHAGGTNGPITYSILSGNE 2111
Query: 332 EDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDEN 389
+ F + P T +++ DF + LV++AE AF L + + D N
Sbjct: 2112 KGT---FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAF---AFTVLTLTLQDAN 2165
Query: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL---N 446
+ +P F P Y ++ ES P L PL V D D++ ++ L
Sbjct: 2166 DNAPRFLRPHYVAFLPESRP----------LEGPLLQVEAD-DLDQGSGGQISYSLAASQ 2214
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVN-----IQVMD 501
+F V T T +T +DRE + A D P +V + V+D
Sbjct: 2215 PARGLFHVDPT--TGTITTTAILDREIWAETRLVLMATD---RGSPALVGSATLTVMVID 2269
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV--GAQGDFIIN 559
NDN PT P+ +++ V D G + Q+T D D +G + + +L G Q F +
Sbjct: 2270 TNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVG 2325
Query: 560 KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITA 619
+ G +++ TG LD E DRY L + A
Sbjct: 2326 RYGGRVSL----------------------------TG------PLDFEQCDRYQLQLLA 2351
Query: 620 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 679
DG +G + TV +V DVNDNAP F L + + + + + V ATD D+G NG
Sbjct: 2352 HDGPHEGRANLTV--LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANG 2409
Query: 680 QVHYSLGNFNNLFRIT-SNGSIYT---AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 735
+ Y L + + F + +NG+++T V L + ++V+ A D R + T+
Sbjct: 2410 HISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVH 2469
Query: 736 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG---ANVSYRIRSPEVKH 792
+++ D +D++P FT S Y V V E+LP G+T+L +EA D D A V Y I S
Sbjct: 2470 VQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR 2529
Query: 793 FFALHPFTGE--------------LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 838
F L P E L LL LD+E+ ++ A D +
Sbjct: 2530 VFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVA----AADRGQPPQSSV 2585
Query: 839 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 898
VTV V D+ND PPVF++ Y+ V D G + V A DADP P VR+ V
Sbjct: 2586 VPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPG--PHGLVRFTVSS 2643
Query: 899 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEPVMSSSATVKILVLH 957
P+ +FE++E SG + L+ E +LVV A D G + T+++ ++
Sbjct: 2644 GD---PSGLFELDESSGTLRLAHALDCETQARHQLVVQAADPAGAHFALAPVTIEVQDVN 2700
Query: 958 ------PGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE-- 1005
P + + E +PP GT+V + A A + YS++
Sbjct: 2701 DHGPAFPLNLLSTSVAENQPP--------GTLVTTLHAIDGDAGAFGRLRYSLLEAGPGP 2752
Query: 1006 --EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEI 1063
+ F +N+ TG + P DYE S+ L V A NL S S T V +
Sbjct: 2753 EGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA----GNL---SASVTVSVLVTG 2805
Query: 1064 QDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112
+DE + PVF + V E AR S+ V+ATD+D G ++ Y L
Sbjct: 2806 EDE--YDPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL 2852
Score = 220 bits (560), Expect = 1e-56
Identities = 244/910 (26%), Positives = 383/910 (42%), Gaps = 133/910 (14%)
Query: 142 DNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSN 201
+ P F S AT+ E P GT I + + G T NG I Y I +
Sbjct: 2063 ERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGT------NGPITYSILSGNE----K 2112
Query: 202 DTFEIPLMLTGNIVLRKR--LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
TF I TG I +R L++E R +++QA T LT+ + D +
Sbjct: 2113 GTFSIQPS-TGAITVRSAEGLDFEVSPRLRLVLQAESGGA------FAFTVLTLTLQDAN 2165
Query: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
D P FL RP Y A +PE R E P++ ++A D D+
Sbjct: 2166 DNAPRFL-----------RP-HYVAFLPESRPLE--GPLL---QVEADDLDQG-----SG 2203
Query: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFA 379
I YS+ P FH+ P T ++ ++R+ + LV+ A L A
Sbjct: 2204 GQISYSLAASQPAR--GLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSA 2261
Query: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
L + ++D N+ P P ++ + E A +G+ I+ ++ D D P
Sbjct: 2262 TLTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIA---------QVTGNDVD----SGP 2307
Query: 440 ELHLFLNDY--TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNI 497
L L+ F+V + G ++L P+D E+ Y + A DG E + +
Sbjct: 2308 VLWYVLSPSGPQDPFSVGRYG--GRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLT-V 2364
Query: 498 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI 557
V D NDN P F + Y V + PG +++ ++A D D G+NG I+Y + A G +
Sbjct: 2365 LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSV 2424
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILII 617
L TI V AL + + +++
Sbjct: 2425 DPNNGTLFTIVGTV--------------------------------ALGHDGSGAVDVVL 2452
Query: 618 TASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAG 676
A D G P + ATV++ + D ND+AP F R + + + ++ATD D
Sbjct: 2453 EARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGS 2512
Query: 677 -INGQVHYSL--GNFNNLFRITSN---------------GSIYTAVKLNREVRDYYELVV 718
+ V YS+ GN+ +F++ G + L+ E Y L V
Sbjct: 2513 RSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTV 2572
Query: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 778
A D P+ S + + + VLD++DN PVFT ++Y V V E+ P G +L +EA D D G
Sbjct: 2573 AAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPG 2632
Query: 779 AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
+ V + + S + F L +G L L +LD E +A +V+A D G
Sbjct: 2633 PHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCET----QARHQLVVQAADPAGA-HF 2687
Query: 837 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 896
+A VT+ V+D+ND+ P F + VA + GT +TT++A D D R+RY +
Sbjct: 2688 ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAF--GRLRYSL 2745
Query: 897 DDV-QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 955
+ P F + +G + RV + E T F+L+V A D G +S+S TV +LV
Sbjct: 2746 LEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLV 2803
Query: 956 LHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFG 1010
E P F + V E A +G +G + A + ++YS+ + + FG
Sbjct: 2804 TGEDEYDPVFLAPAFH-FQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSS--PYFG 2860
Query: 1011 INNITGVIYV 1020
IN TG +Y+
Sbjct: 2861 INQTTGALYL 2870
Score = 215 bits (547), Expect = 4e-55
Identities = 299/1193 (25%), Positives = 473/1193 (39%), Gaps = 200/1193 (16%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
+T R LDR+ I+ V + + VR+ V D ND++PTF V
Sbjct: 1704 TTLRALDREEQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVP 1761
Query: 158 E-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
E P T+ A+D D G NGQ++Y I D + F + L +G
Sbjct: 1762 EGQDPQTLTMLR-------ASDPDVGANGQLQYRIL----DGDPSGAFVLDLA-SGEFGT 1809
Query: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF-LPCVLVPNTR 275
+ L+ E + + + I+A D Q + T LTV VLD +D P F +P V
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQ---PALSATLLLTVTVLDANDHAPAFPVPAYSV---- 1862
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
PE++ + +QA D D + Y + GT
Sbjct: 1863 --------------EVPEDVPAGTLLLQLQAHDPDAGANGH-----VTYYLGAGTAGA-- 1901
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPY 394
F + P + EL ++R+ + + A + PL + I + D N+ +P
Sbjct: 1902 --FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 1959
Query: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD--------PELHLFLN 446
F + + P +T + +L + LR A D+D P ++
Sbjct: 1960 FPTSPLRLRLPRPGPSFSTPTLAL---ATLR--AEDRDAGANASILYRLAGTPPPGTTVD 2014
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
YT V ++ + L P DR T S ++ + + +
Sbjct: 2015 SYTGEIRVARSPVA-----LGPRDR----VLFIVATDLGRPARSATGVIIVGLQGEAERG 2065
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLI 565
P FP S + + + PG ++ AV A G+NG ITY IL G + G F I +TG I
Sbjct: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAI 2124
Query: 566 TI----------APGVEMIV----GRTYALTV------QAADNAP--------------- 590
T+ +P + +++ G +A TV A DNAP
Sbjct: 2125 TVRSAEGLDFEVSPRLRLVLQAESGGAFAFTVLTLTLQDANDNAPRFLRPHYVAFLPESR 2184
Query: 591 ------------------------------PA------ERSTGILTLGKALDRESTDRYI 614
PA + +TG +T LDRE
Sbjct: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDREIWAETR 2244
Query: 615 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATD 672
L++ A+D G P +AT+ ++V D NDN P P L V E+ + + QV D
Sbjct: 2245 LVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ--PWELRVSEDALLGSEIAQVTGND 2302
Query: 673 PDAG---------INGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDG 723
D+G Q +S+G + +T L+ E D Y+L ++A DG
Sbjct: 2303 VDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG--------PLDFEQCDRYQLQLLAHDG 2354
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--V 781
P L + V D++DN+P F+ S Y V++ E+ P G+ IL + A D D GAN +
Sbjct: 2355 ---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHI 2411
Query: 782 SYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATV 841
SY + SP F++ P G L + D ++ ++EA D ATV
Sbjct: 2412 SYHLASP--ADGFSVDPNNGTLFTIVG-TVALGHDGSGAVDVVLEARDHGAPGRAARATV 2468
Query: 842 TVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ- 900
V ++D ND+ P F+ Y+ V D G+ + T+ A DAD A+ V Y +
Sbjct: 2469 HVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA-VDYSIISGNW 2527
Query: 901 ---FPYPASIFEVEEDSGR-------VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 950
F + E E +G ++ L+ E T + L V A D G+P SS
Sbjct: 2528 GRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVP 2587
Query: 951 VKILVLHPGEIPR-FTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVSGNEE 1006
V + VL + P FT+ YR + ++ V ++ A + + +++ SG+
Sbjct: 2588 VTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTVSSGDPS 2647
Query: 1007 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN--TAKVYIEIQ 1064
F ++ +G + + LD ET+ + L VQA P+ ++ A V IE+Q
Sbjct: 2648 GLFELDESSGTLRLAHALDCETQARHQLVVQAAD----------PAGAHFALAPVTIEVQ 2697
Query: 1065 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI-IPPIKEGKEG 1123
D N+H P F V+E+ T V + A D D G + + Y L+ P EG+E
Sbjct: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPGPEGREA 2757
Query: 1124 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
F + + TG ++ + F F+ V A D S VLV+ ++ D
Sbjct: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD 2810
Score = 199 bits (505), Expect = 3e-50
Identities = 188/619 (30%), Positives = 278/619 (44%), Gaps = 68/619 (10%)
Query: 593 ERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR 652
+ +G++ + LDRE DRY DG +T V + V D+ND+AP F P
Sbjct: 95 DEHSGVVRTARVLDREQRDRYRFTAVTPDG-----ATVEVTVRVADINDHAPAF-PQARA 148
Query: 653 NLSVVEEEANAFVGQVK-ATDPDAGINGQVHYSLGN--FNNLFRI-TSNGSIYTAV---- 704
L V E A ++ A D DAG G Y+L FR+ T G T V
Sbjct: 149 ALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELV 208
Query: 705 ---KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 761
+L+RE R +Y L + A DG PR + L + +LDI+D++P F S Y +V E+L
Sbjct: 209 VTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESL 268
Query: 762 PAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 817
G+ +LQ+ A D D G N V+Y I R E F++ TG L L R LD+E Q
Sbjct: 269 APGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFE----Q 324
Query: 818 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 877
+V+A D G A VTV V+D ND P + V + G+P
Sbjct: 325 RRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMT-------VIFLSADGSP---- 373
Query: 878 YAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEEDSGRVITRVN----------LNEE 926
+A PPG +R+ DD F + E E + T+ + L+ E
Sbjct: 374 QVSEAAPPGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDRE 433
Query: 927 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKGT 982
+ L V A D G P + + A VLH ++ P F ++ YRP P+ E+A G+
Sbjct: 434 ERDAYNLRVTATDSGSPPLRAEAA---FVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGS 490
Query: 983 MVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
V ++A N + YS+ G F I+ +G+I LDYE
Sbjct: 491 FVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQ------- 543
Query: 1039 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1098
L VV + +P +++A V + +QD N++ P FQ+ FY + E + T L+V AT
Sbjct: 544 PQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTAT 603
Query: 1099 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG-LIKTAMLFHNMRRSYFKFQVIATDDY 1157
D D+G + +++Y L G F ++ ++G + T L + S F F V A D
Sbjct: 604 DADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVD-- 661
Query: 1158 GKGLSGKADVLVSVVNQLD 1176
G GL V V + ++ D
Sbjct: 662 GGGLKSMVYVKVFLSDEND 680
Score = 196 bits (499), Expect = 1e-49
Identities = 182/656 (27%), Positives = 289/656 (44%), Gaps = 69/656 (10%)
Query: 463 LTLLQPVDREEQQTYTFSITAFDGVQESE--PVIVNIQVMDANDNTPTFPEISYDVYVYT 520
L + +DRE + Y + A+DG ++++ ++D ND+ P F + Y V
Sbjct: 207 LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266
Query: 521 DMRPGDSVIQLTAVDADEGSNGEITYEI---LVGAQGDFIINKTTGLITIAPGVEMIVGR 577
+ PG V+Q+ A DAD G NG +TYEI G F I+ TGL+ + ++ R
Sbjct: 267 SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRR 326
Query: 578 TYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 637
+ L VQA D E + +T+ ++ +I ++DG P
Sbjct: 327 VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSP------------- 373
Query: 638 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 697
V++ AP V ++ +DPD G V+ SL F +++
Sbjct: 374 QVSEAAP----------------PGQLVARISVSDPDDGDFAHVNVSLEGGEGHFALSTQ 417
Query: 698 GSIY----TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 753
S+ A +L+RE RD Y L V ATD P + + V D++DN+P F Y
Sbjct: 418 DSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLY 477
Query: 754 --TVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSL 809
L E LP G+ ++++ A+D D G N V+Y + H+F++ P +G ++ SL
Sbjct: 478 RPEPLPEVALP-GSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASL 536
Query: 810 DYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 867
DYE P + +V A D G +PP ATV+V ++D+ND P F + Y +
Sbjct: 537 DYELEPQPQ----LIVVATD--GGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEG 590
Query: 868 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EE 926
GT V A DAD P + Y + + F ++ SG V T L+ ++
Sbjct: 591 TQPGTCFLQVTATDADSG--PFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQ 648
Query: 927 PTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVG 985
+ F V A D G + S VK+ + + P+F EY +S + GT V
Sbjct: 649 GPSSFDFTVTAVDGGG--LKSMVYVKVFLSDENDNPPQFYPREY-AASISAQSPPGTAVL 705
Query: 986 VISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1041
+ A +Q + Y I++GN F ++ +G++ V PL + L + A+
Sbjct: 706 RLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDG 765
Query: 1042 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1097
+ A PS A+V I I PP+F++ Y+ V ED TSV V+A
Sbjct: 766 GGLQAE---PS----ARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA 814
Score = 182 bits (463), Expect = 2e-45
Identities = 271/1132 (23%), Positives = 450/1132 (39%), Gaps = 182/1132 (16%)
Query: 111 IHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
+H +VVQ + + ++G+ V + VRD NDN P+ T IF
Sbjct: 327 VHELVVQARDGGAHPELGSAF---VTVHVRDANDNQPSM----------------TVIF- 366
Query: 169 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN--------------- 213
S D + P GQ+ V + + DP D + + L G
Sbjct: 367 -LSADGSPQVSEAAPPGQL--VARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423
Query: 214 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
+ + +RL+ E++ Y + + A D + + V D +D P F
Sbjct: 424 VCVARRLDREERDAYNLRVTATDSG---SPPLRAEAAFVLHVTDVNDNAPAF-------- 472
Query: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333
R L +PE+ P +V + DQ N Q + YS+ G
Sbjct: 473 ---DRQLYRPEPLPEVALP---GSFVVRVTARDPDQGTNGQ-------VTYSLAPGA--- 516
Query: 334 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 393
+ +F + P + ++ ++ + + L++ A PL + A + + + D N+ P
Sbjct: 517 HTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEP 576
Query: 394 YFTMPSYQGYILESAPVGA-----TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448
F Y + E G T +D+ + L +L + + P + + +
Sbjct: 577 QFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI--DAH 634
Query: 449 TSVFTVTQTGITRYLTLLQPVDREE-QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 507
+ T+T +DR++ ++ F++TA DG V V + + D NDN P
Sbjct: 635 SGDVCTTRT-----------LDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI 567
F Y + PG +V++L A D D+GS+G ++Y IL G
Sbjct: 684 QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAG---------------- 727
Query: 568 APGVEMIVGRTYALTVQAADNAPP---AERSTGILTLGKALDRESTDRYILIITASDGRP 624
N+PP + +G+LT+ L R + L I A DG
Sbjct: 728 --------------------NSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGG 767
Query: 625 -DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVH 682
+A V+I + P+F+ L SV E+ A VG V+A +P G V
Sbjct: 768 LQAEPSARVDISIVPGTPTPPIFE-QLQYVFSVPEDVAPGTSVGIVQAHNP-PGRLAPVT 825
Query: 683 YSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVL 739
SL G+ LF + + +G + T L+RE+ + V V P + + + +
Sbjct: 826 LSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLD 885
Query: 740 DIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALH 797
D++DNSP F TVL+ N GT I + A D D G N V++ + + F +
Sbjct: 886 DVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVD 944
Query: 798 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA--TVTVIVKDM--NDYPP 853
P TG + L+R L P E + EA D G PP + + V+V+D+ P
Sbjct: 945 PTTGHVRLMRPLGPSGGPAHELEL----EARD--GGSPPRTSHFRLRVVVQDVGTRGLAP 998
Query: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 913
F+ Y+ + GT + V A+ P G P + Y + +S F +E
Sbjct: 999 RFNSPTYRVDLPSGTTAGTQVLQVQAQ--APDGGP---ITYH---LAAEGASSPFGLEPQ 1050
Query: 914 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM---SSSATVKILVLHPGEIPRFTQEEYR 970
SG + R L+ E ++ L V+A + + + +ATV++ +L+ E E+
Sbjct: 1051 SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPT 1110
Query: 971 PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TFGINNITGVIYVNGPLD 1025
V+E GT VG + A + N + YS+ +E+ F I+ TG + LD
Sbjct: 1111 FLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1170
Query: 1026 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF-QKKFYIGG--- 1081
E ++SY L VQ + + P +S T V++ + D N++ P F Q GG
Sbjct: 1171 REQQSSYQLLVQ-------VQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLP 1223
Query: 1082 --VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF 1139
V + T V ++A D D G + Y L P G E F + ++G + TA
Sbjct: 1224 IQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGP----GSELFSLHPHSGELLTAAPL 1279
Query: 1140 HNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEK 1191
R ++ + A D S +LV V+ + + PP L E+
Sbjct: 1280 IRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARL----AEPPPDLAER 1327
Score = 181 bits (458), Expect = 8e-45
Identities = 263/1109 (23%), Positives = 428/1109 (38%), Gaps = 151/1109 (13%)
Query: 42 TIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGR 101
T +A+ E GT V + GP+ + SL+ L + K TG
Sbjct: 1110 TFLAVAENQPPGTS-VGRVFATDRDSGPNGRLTYSLQQ------LSEDSKAFRIHPQTGE 1162
Query: 102 V-----LDRDPPMNIHSIVVQVQC----INKKVGTIIYHEVRIVVRDRNDNSPTFKHESY 152
V LDR+ + + ++VQVQ GT V + V D NDNSPTF S
Sbjct: 1163 VTTLQTLDREQQSS-YQLLVQVQDGGSPPRSTTGT-----VHVAVLDLNDNSPTFLQASG 1216
Query: 153 YA------TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI 206
A V + P GT + T A D D+G NG I Y + ++ F +
Sbjct: 1217 AAGGGLPIQVPDRVPPGTLVTT-----LQAKDPDEGENGTILYTLT-----GPGSELFSL 1266
Query: 207 PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFL 266
+G ++ L ++ Y + + A+D+ + R+ + L V VL L
Sbjct: 1267 HPH-SGELLTAAPLIRAERPHYVLTLSAHDQG---SPPRSASLQLLVQVLPSARLAEP-- 1320
Query: 267 PCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 326
P+ + P + + E L P + + A + P+ + Y++
Sbjct: 1321 ----PPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-------PAGVGALTYTL 1369
Query: 327 LVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL 386
+ G D F + + L L P++ + + + + G + +++
Sbjct: 1370 VGGA--DPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQ 1427
Query: 387 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 446
DEN +P F + E+ GA + A D D + L
Sbjct: 1428 DENEHAPAFARDPLALALPENPEPGAAL---------YTFRASDADGPGPNSDVRYRLLR 1478
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-----GVQESEPVIVNIQVMD 501
V + T L+ + +DRE + A D + + V + V D
Sbjct: 1479 QEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTD 1538
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
NDN P F S V + D PG + + + A D D G ++Y + G G F ++ +
Sbjct: 1539 ENDNAPVFASPSR-VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSS 1597
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD 621
TG +++ ++ + LTV A+D+ P +T +LT
Sbjct: 1598 TGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLT--------------------- 1636
Query: 622 GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEAN---AFVGQVKATDPDAGIN 678
+ V DVND AP F + SV+ E N + ++ATDPD G N
Sbjct: 1637 ------------VSVADVNDEAPTFQ---QQEYSVLLRENNPPGTSLLTLRATDPDVGAN 1681
Query: 679 GQVHYSLGNFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIK 737
GQV Y G + F + + + T ++ L+RE ++ L V A D P+ + +T+ +
Sbjct: 1682 GQVTYG-GVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRVA 1740
Query: 738 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 795
V D +D++P F ++ ++ V E T+ + A D D+GAN + YRI + F
Sbjct: 1741 VEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRILDGDPSGAFV 1799
Query: 796 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPP 853
L +GE +R LD E E + +EA D G P AT +TV V D ND+ P
Sbjct: 1800 LDLASGEFGTMRPLDREV----EPAFQLRIEARD--GGQPALSATLLLTVTVLDANDHAP 1853
Query: 854 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 913
F Y V D GT + + A D D V Y + A F +E
Sbjct: 1854 AFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGA--NGHVTYYLG----AGTAGAFLLEPS 1907
Query: 914 SGRVITRVNLNEEPTTIFKLVVVAFDDG-----EPVMSSSATVKILVLHPGEIPRFTQEE 968
SG + T L+ E + V A D +S + TV+ + H P
Sbjct: 1908 SGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRL 1967
Query: 969 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1024
P P +T + + A A N SI+Y + +G +++ TG I V
Sbjct: 1968 RLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGTPPPGTTVDSYTGEIRV---- 2022
Query: 1025 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1084
R+ L + L +V +L P++S T + + +Q E P F + + E
Sbjct: 2023 ---ARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRE 2079
Query: 1085 DARMFTSVLRVKATDKDTGN----YSVMA 1109
+A T ++ +A N YS+++
Sbjct: 2080 NAPPGTPIVSPRAVHAGGTNGPITYSILS 2108
Score = 177 bits (450), Expect = 7e-44
Identities = 284/1183 (24%), Positives = 466/1183 (39%), Gaps = 161/1183 (13%)
Query: 46 IDEESRNGTILVDNM--LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVL 103
IDEE GT++ D L GTA I V + +D ++ T RVL
Sbjct: 51 IDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV---RTARVL 107
Query: 104 DRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
DR+ V G + EV + V D ND++P F V E T G
Sbjct: 108 DREQRDRYRFTAVTPD------GATV--EVTVRVADINDHAPAFPQARAALQVPEHTAFG 159
Query: 164 TTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------YNPDDPTSNDTFEIPLMLTGNIVL 216
T A D D G G Y + + + D +P +V+
Sbjct: 160 TRYPL-----EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVP-----ELVV 209
Query: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
L+ E+++ Y + ++A D + R L V +LD +D P F
Sbjct: 210 TGELDRENRSHYMLQLEAYDGG---SPPRRAQALLDVTLLDINDHAPAF----------- 255
Query: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE-DYP 335
Y A + E P +P++ + A D D + + Y I E D P
Sbjct: 256 -NQSRYHAVVSESLAPG--SPVL---QVFASDADAGVNG-----AVTYEINRRQSEGDGP 304
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
F + T L L P++ + + +LV++A HP A + + + D N+ P
Sbjct: 305 --FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSM 362
Query: 396 TM----PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
T+ + E+AP G ++ RI D D D +++ L
Sbjct: 363 TVIFLSADGSPQVSEAAPPGQLVA---------RISVSDPD--DGDFAHVNVSLEGGEGH 411
Query: 452 FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVNIQVMDANDNTP 507
F + TQ + + + + +DREE+ Y +TA D +E V + V D NDN P
Sbjct: 412 FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAP 470
Query: 508 TFPEISYDVYVYTDMR-PGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLI 565
F Y ++ PG V+++TA D D+G+NG++TY + GA F I+ T+G+I
Sbjct: 471 AFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGII 530
Query: 566 TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRP 624
T A +LD E + LI+ A+D G P
Sbjct: 531 TTA----------------------------------ASLDYELEPQPQLIVVATDGGLP 556
Query: 625 DGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHY 683
S+ATV++ + DVNDN P F + +L + F+ QV ATD D+G G + Y
Sbjct: 557 PLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFL-QVTATDADSGPFGLLSY 615
Query: 684 SLG-----NFNNLFRITS-NGSIYTAVKLNREV-RDYYELVVVATDGAVHPRHSTLTLAI 736
SLG + + FRI + +G + T L+R+ ++ V A DG S + + +
Sbjct: 616 SLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG--GLKSMVYVKV 673
Query: 737 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFF 794
+ D +DN P F Y + P GT +L++ A D D G++ +SY I + F
Sbjct: 674 FLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLF 733
Query: 795 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPV 854
L +G L++ L A + + + A D G A V + + PP+
Sbjct: 734 TLDEQSGLLTVAWPLARRA----NSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
Query: 855 FSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 914
F + Y V D GT + V A +PPG R+ + P +F ++ S
Sbjct: 790 FEQLQYVFSVPEDVAPGTSVGIVQAH--NPPG----RLAPVTLSLSGGDPRGLFSLDAVS 843
Query: 915 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEE---YR 970
G + T L+ E + V G P + A V++L+ + P F E
Sbjct: 844 GLLQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLL 903
Query: 971 PPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1030
PP + T+ + + +N + +++++G F ++ TG + + PL
Sbjct: 904 PPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGP 962
Query: 1031 SYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH--PPVFQKKFYIGGVSEDARM 1088
++ L ++A + P +++ ++ + +QD P F Y +
Sbjct: 963 AHELELEA-------RDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTA 1015
Query: 1089 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFK 1148
T VL+V+A D G + Y L + F +E +G + + +
Sbjct: 1016 GTQVLQVQAQAPDGG---PITYHL---AAEGASSPFGLEPQSGWLWVRAALDREAQELYI 1069
Query: 1149 FQVIATDDYGKGL---SGKADVLVSVVNQLDMQVIVSNVPPTL 1188
+V+A L +G A V VS++NQ + +S P L
Sbjct: 1070 LKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFL 1112
Score = 85.1 bits (209), Expect = 6e-16
Identities = 123/525 (23%), Positives = 209/525 (39%), Gaps = 93/525 (17%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDG-PNGQIEY-- 189
V + ++D+ND++P+F Y V E P G+T+ T ATD D + ++Y
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-----LEATDADGSRSHAAVDYSI 2522
Query: 190 -------VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
V Q P + ++ G +VL + L++E T+Y + + A DR Q
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ--- 2579
Query: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
+++ +TV VLD +D P+F TR +Y+ +PE TP + V
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVF--------TR----ASYRVTVPE-DTPVGAELLHV-- 2624
Query: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
+A D D P + +++ G P F + + L L ++ + +
Sbjct: 2625 --EASDAD-----PGPHGLVRFTVSSGDPSG---LFELDESSGTLRLAHALDCETQARHQ 2674
Query: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
LV++A G A A + IE+ D N+ P F + + E+ P G ++
Sbjct: 2675 LVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT------ 2727
Query: 423 PLRIVALDKD-----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 471
+ A+D D +E PE F + + T L P D
Sbjct: 2728 ---LHAIDGDAGAFGRLRYSLLEAGPGPEGR-------EAFALNSS--TGELRARVPFDY 2775
Query: 472 EEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 531
E +++ + A D S V V++ V ++ P F ++ V R G S+ +
Sbjct: 2776 EHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHV 2835
Query: 532 TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 591
A D D G++G + Y L + F IN+TTG AL ++ AP
Sbjct: 2836 QATDEDGGADGLVLYS-LATSSPYFGINQTTG----------------ALYLRVDSRAPG 2878
Query: 592 AERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 636
+ +T + G R R + + + G G+ +ATV + V
Sbjct: 2879 SGTAT---SGGGGRTRREAPRELRLEVIARGPLPGSRSATVPVTV 2920
Score = 31.2 bits (69), Expect = 10.0
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 9/76 (11%)
Query: 1304 GALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAA 1363
GA+ A ++++ + A+++ LV R R+AE QAA P A ++
Sbjct: 2939 GAVAASLGVVVVLALAALVLGLVRARS---RKAEAAPGPMSQAA-PLASDSLQKLGR--- 2991
Query: 1364 PPPPPPPPPGAHLYEE 1379
PP PPP HLY +
Sbjct: 2992 --EPPSPPPSEHLYHQ 3005
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 228 bits (581), Expect = 4e-59
Identities = 243/929 (26%), Positives = 403/929 (43%), Gaps = 114/929 (12%)
Query: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
Query: 341 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Y+ + E+ G I L++ A D D + I
Sbjct: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Query: 460 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Query: 572 EMIVGRTYALTVQAAD-NAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 630
+ R YAL ++A D PP +TG+
Sbjct: 609 DFEAEREYALRIRAQDAGRPPLSNNTGL-------------------------------- 636
Query: 631 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLG 686
+I V D+ND+ P+F P +SV+E NA +G ++A D D G N ++ YSL
Sbjct: 637 -ASIQVVDINDHIPIF-VSTPFQVSVLE---NAPLGHSVIHIQAVDADHGENARLEYSLT 691
Query: 687 NF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 743
+ F I S G + + L+RE ++Y V A D P ++ ++ + VLD++D
Sbjct: 692 GVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVND 751
Query: 744 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL--HPFTG 801
N P FT Y + + E+ GT+++ + A D D + +SY+I ++ FA+ G
Sbjct: 752 NRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVG 811
Query: 802 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 861
++L LDY+ QE ++ A D V + + D N + PVF Y
Sbjct: 812 LVTLALPLDYK----QERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQSAHYS 864
Query: 862 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 921
V D G+ I + A D D +R+ Y ++D P F ++ DSG + +
Sbjct: 865 VSVNEDRPMGSTIVVISASDDDVG--ENARITYLLED-NLPQ----FRIDADSGAITLQA 917
Query: 922 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATK 980
L+ E + L + A D+G P + + V+++V + P+F Y VSE A
Sbjct: 918 PLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHY-TGLVSEDAPP 976
Query: 981 GTMVGVISA----AAINQSIVYSIVSGNEED-TFGINNITGVIYVNGPLDYETRTSYVLR 1035
T V ISA A N + Y+ +G + D F I +G++ LD E + Y L
Sbjct: 977 FTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT 1036
Query: 1036 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1095
A + VP + + +QD N++ PVF + + V E++ + + V ++
Sbjct: 1037 AYA-------VDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQI 1089
Query: 1096 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAM-LFHNMRRSYFKFQVIAT 1154
A D D G + + Y+++ I E F ++ ++G + + L + R+ Y VI
Sbjct: 1090 TAVDPDEGPNAHIMYQIVEGNI---PELFQMDIFSGELTALIDLDYEARQEY----VIVV 1142
Query: 1155 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
L +A V V +V+Q D +++N
Sbjct: 1143 QATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
Score = 226 bits (576), Expect = 2e-58
Identities = 219/772 (28%), Positives = 339/772 (43%), Gaps = 107/772 (13%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGT-IIYHEVRIVVRDRNDNSPTFKHESYYA 154
++++GRV DR+ M + +VV+ ++ G V I V D NDN+P F + Y A
Sbjct: 495 ISTSGRV-DREH-MESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
Query: 155 TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNI 214
V E T + ATD D NG ++ YN S F I LTG I
Sbjct: 553 QVREDVRPHTVVLRVT-----ATDRDKDANG----LVHYNIISGNSRGHFAID-SLTGEI 602
Query: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
+ L++E + Y + I+A D + T ++ V+D +D P+F+ +
Sbjct: 603 QVVAPLDFEAEREYALRIRAQDAGRP--PLSNNTGLASIQVVDINDHIPIFVSTPFQVSV 660
Query: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
+ PL + IQA+D D + + YS L G D
Sbjct: 661 LENAPLGHSVI-----------------HIQAVDADHG-----ENARLEYS-LTGVAPDT 697
Query: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
P F ++ T +S+ P++R+ + + ++A PL A A + + +LD N+ P
Sbjct: 698 P--FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPE 755
Query: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
FTM Y + E A VG TS + + A+D+D + + + F +
Sbjct: 756 FTMKEYHLRLNEDAAVG---------TSVVSVTAVDRDANSA--ISYQITGGNTRNRFAI 804
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
+ G +TL P+D ++++ + +TA D + V+I + DAN + P F Y
Sbjct: 805 STQGGVGLVTLALPLDYKQERYFKLVLTASDRALH-DHCYVHINITDANTHRPVFQSAHY 863
Query: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 574
V V D G +++ ++A D D G N ITY +L F I+ +G IT+ ++
Sbjct: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITY-LLEDNLPQFRIDADSGAITLQAPLDYE 922
Query: 575 VGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 634
TY L + A DN G P T V +
Sbjct: 923 DQVTYTLAITARDN---------------------------------GIPQKADTTYVEV 949
Query: 635 VVTDVNDNAPVFDPYLPRNLSVVEEEANAF--VGQVKATDPDAGINGQVHYSLGN---FN 689
+V DVNDNAP F +V E+A F V Q+ ATD DA NG+V Y+ N +
Sbjct: 950 MVNDVNDNAPQF--VASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
Query: 690 NLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF 748
F I ++G + T +L+RE YEL A D V P + +++ + V D++DN+PVF
Sbjct: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF 1067
Query: 749 TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLL 806
+ V V+EN G+ + QI A D D G A++ Y+I + F + F+GEL+ L
Sbjct: 1068 PAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTAL 1127
Query: 807 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 856
LDYEA QE I + T P ++ TV V+ D ND PV +
Sbjct: 1128 IDLDYEA--RQEYVIV-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
Score = 223 bits (568), Expect = 1e-57
Identities = 237/911 (26%), Positives = 399/911 (43%), Gaps = 112/911 (12%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
Query: 193 YNP-DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
P + FEI +G I R++ E Y ++++A+D+ Q R+ T +
Sbjct: 474 GPPAARAAAAAAFEID-PRSGLISTSGRVDREHMESYELVVEASDQGQEPGP-RSATVRV 531
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
Query: 312 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
Query: 371 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
Query: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GV 487
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
Query: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
Query: 548 ILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDR 607
I G + T G G++TL LD
Sbjct: 793 ITGGNTRNRFAISTQG-------------------------------GVGLVTLALPLDY 821
Query: 608 ESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVG 666
+ + L++TASD V+I +TD N + PVF ++SV E+ + +
Sbjct: 822 KQERYFKLVLTASDRALH--DHCYVHINITDANTHRPVFQS-AHYSVSVNEDRPMGSTIV 878
Query: 667 QVKATDPDAGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAV 725
+ A+D D G N ++ Y L + FRI +G+I L+ E + Y L + A D +
Sbjct: 879 VISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGI 938
Query: 726 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 783
+ T + + V D++DN+P F S YT LV E+ P T++LQI A D D AN V Y
Sbjct: 939 PQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY 998
Query: 784 RIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIAT 840
++ E F + P +G + +R L D+EA + + A+ + +PP +
Sbjct: 999 TFQNGEDGDGDFTIEPTSGIVRTVRRL------DREAVSVYELTAYAVDRGVPPLRTPVS 1052
Query: 841 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 900
+ V+V+D+ND PVF ++ V +++ G+ + + A DP P + + Y++ +
Sbjct: 1053 IQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITA--VDPDEGPNAHIMYQIVEGN 1110
Query: 901 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960
P +F+++ SG + ++L+ E + +VV A P++S + LV
Sbjct: 1111 IP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVRLVDQNDN 1165
Query: 961 IPRFTQEEY----RPPPVSELATKGTMVGVISA--AAINQSIVYSIVSGNEEDTFGINNI 1014
P + S+ G ++G I A ++ + YS GNE +N
Sbjct: 1166 SPVLNNFQILFNNYVSNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQT 1224
Query: 1015 TGVIYVNGPLD 1025
+G + ++ LD
Sbjct: 1225 SGELRLSRKLD 1235
Score = 217 bits (553), Expect = 8e-56
Identities = 224/795 (28%), Positives = 348/795 (43%), Gaps = 102/795 (12%)
Query: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
Query: 448 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
Query: 504 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNA-PPAERSTGILTLGKALDRESTDRYILI 616
I+ +GLI+ + V+ +Y L V+A+D P RS
Sbjct: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRS--------------------- 526
Query: 617 ITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPD 674
+T V+I V D NDNAP F R ++ V E+ + V +V ATD D
Sbjct: 527 -----------ATVRVHITVLDENDNAPQFSE--KRYVAQVREDVRPHTVVLRVTATDRD 573
Query: 675 AGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 731
NG VHY++ GN F I S G I L+ E Y L + A D P +
Sbjct: 574 KDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNN 633
Query: 732 LTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 788
LA I+V+DI+D+ P+F ++ + V V EN P G +++ I+A D D G N + Y +
Sbjct: 634 TGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGV 693
Query: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKD 847
F ++ TG +S+ LD E+ F VEA D +G+ P A+VTV V D
Sbjct: 694 APDTPFVINSATGWVSVSGPLDRESV----EHYFFGVEARD-HGSPPLSASASVTVTVLD 748
Query: 848 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 907
+ND P F+ + Y + DA GT + +V A D D S + Y++ +I
Sbjct: 749 VNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD----ANSAISYQITGGNTRNRFAI 804
Query: 908 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE 967
+ G V + L+ + FKLV+ A D + V I + Q
Sbjct: 805 -STQGGVGLVTLALPLDYKQERYFKLVLTASD---RALHDHCYVHINITDANTHRPVFQS 860
Query: 968 EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1023
+ V+E G+ + VISA+ N I Y + + F I+ +G I + P
Sbjct: 861 AHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAP 918
Query: 1024 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVS 1083
LDYE + +Y L + A + +P K++T V + + D N++ P F Y G VS
Sbjct: 919 LDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVS 971
Query: 1084 EDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG---FVVETYTGLIKTAMLFH 1140
EDA FTSVL++ ATD+D + Y + G++G F +E +G+++T
Sbjct: 972 EDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGEDGDGDFTIEPTSGIVRTVRRLD 1026
Query: 1141 NMRRSYFKFQVIATD 1155
S ++ A D
Sbjct: 1027 REAVSVYELTAYAVD 1041
Score = 211 bits (536), Expect = 7e-54
Identities = 205/727 (28%), Positives = 328/727 (45%), Gaps = 91/727 (12%)
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
A + P FP+ +Y V + G +V+++ A D D G G + Y + + +++
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAA-----LMNSRS 372
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD 621
L +I P +G++ ALDRES +R+ L +TA D
Sbjct: 373 LELFSIDP-------------------------QSGLIRTAAALDRESMERHYLRVTAQD 407
Query: 622 -GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 680
G P ++T V + V D ND++PVF+ R E + Q++ATD DA N
Sbjct: 408 HGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNAN 467
Query: 681 VHY-------SLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVH--PRHS 730
+ Y + F I +G I T+ +++RE + YELVV A+D PR +
Sbjct: 468 LRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSA 527
Query: 731 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSP 788
T+ + I VLD +DN+P F+ Y V E++ T +L++ A D D AN V Y I S
Sbjct: 528 TVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISG 587
Query: 789 EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP-----GIATVTV 843
+ FA+ TGE+ ++ LD+EA E + A D PP G+A++ V
Sbjct: 588 NSRGHFAIDSLTGEIQVVAPLDFEA----EREYALRIRAQD--AGRPPLSNNTGLASIQV 641
Query: 844 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 903
+ D+ND+ P+F ++ V +A G + + A DAD +R+ Y + V
Sbjct: 642 V--DINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG--ENARLEYSLTGVA--- 694
Query: 904 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 962
P + F + +G V L+ E + V A D G P +S+SA+V + VL + P
Sbjct: 695 PDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRP 754
Query: 963 RFTQEEYRPPPVSELATKGTMVGVISAA--AINQSIVYSIVSGNEEDTFGINNITGV--I 1018
FT +EY ++E A GT V ++A N +I Y I GN + F I+ GV +
Sbjct: 755 EFTMKEYH-LRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLV 813
Query: 1019 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1078
+ PLDY+ + L + A + + V+I I D N H PVFQ Y
Sbjct: 814 TLALPLDYKQERYFKLVLTASDRAL----------HDHCYVHINITDANTHRPVFQSAHY 863
Query: 1079 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1138
V+ED M ++++ + A+D D G + + Y L ++ F ++ +G I
Sbjct: 864 SVSVNEDRPMGSTIVVISASDDDVGENARITYLL-----EDNLPQFRIDADSGAITLQAP 918
Query: 1139 FHNMRRSYFKFQVIATDDYGKGLSGKAD-----VLVSVVNQLDMQVIVSNVPPTLVEKKI 1193
+ + + A D+ G+ KAD V+V+ VN Q + S+ LV +
Sbjct: 919 LDYEDQVTYTLAITARDN---GIPQKADTTYVEVMVNDVNDNAPQFVASHY-TGLVSEDA 974
Query: 1194 EDLTEIL 1200
T +L
Sbjct: 975 PPFTSVL 981
Score = 128 bits (322), Expect = 5e-29
Identities = 156/611 (25%), Positives = 250/611 (40%), Gaps = 121/611 (19%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
Query: 193 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
Query: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
Query: 430 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
Query: 486 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
Query: 545 TYEILVGA-----QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGIL 599
Y+I+ G Q D + T LI
Sbjct: 1103 MYQIVEGNIPELFQMDIFSGELTALID--------------------------------- 1129
Query: 600 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 659
LD E+ Y++++ A+ S ATV++ + D NDN+PV + + + V
Sbjct: 1130 -----LDYEARQEYVIVVQATSAPL--VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSN 1182
Query: 660 EANAF----VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRD 712
++ F +G++ A DPD ++ + YS N L + N G + + KL+
Sbjct: 1183 RSDTFPSGIIGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNRPL 1240
Query: 713 YYELVVVATDG 723
++V TDG
Sbjct: 1241 VASMLVTVTDG 1251
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 202 bits (515), Expect = 2e-51
Identities = 173/603 (28%), Positives = 277/603 (45%), Gaps = 59/603 (9%)
Query: 632 VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNN 690
+ I+V D NDNAP+F P N+S+ E N+ ATDPD G NG HY L N +
Sbjct: 128 IKIIVKDTNDNAPMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 691 LFRI----TSNGSIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
+F + T G + + L+RE +D Y + + DG + ST L + V D++
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALH 797
DN PVF V + EN P GT+++Q+ A D D+G+N R +P K FAL+
Sbjct: 247 DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
Query: 798 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 857
TG +++ RSLD E + A V A D G+ P ATVT+ V D+ND PP
Sbjct: 307 NTTGLITVQRSLDRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDL 360
Query: 858 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASI 907
R +++P + G TVY + DP + + D ++ P +
Sbjct: 361 RY---IISP--ING----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHL 411
Query: 908 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE 967
V ++ + T L+ E T F +VA D G+P ++ +A V++ + + P +
Sbjct: 412 KAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471
Query: 968 EYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1023
VSE +G + ISA + N IVY + G F ++ TGV+ +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRV 529
Query: 1024 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVS 1083
D E + ++ V A + P + A V + + DEN++ P F + VS
Sbjct: 530 FDREEQERFIFTVTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
Query: 1084 EDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMR 1143
E+ +++V + TD D G + ++ + FV++ Y+G+IK+ + F +
Sbjct: 583 ENLPKYSTVGVITVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQ 637
Query: 1144 RSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1203
+S + F V ATD S A V ++V++ D +V + PP+ K+ L+ I
Sbjct: 638 QSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSV 696
Query: 1204 VQE 1206
V E
Sbjct: 697 VAE 699
Score = 179 bits (455), Expect = 2e-44
Identities = 177/577 (30%), Positives = 263/577 (45%), Gaps = 66/577 (11%)
Query: 463 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 520
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 521 DMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYA 580
+ G SVIQL A DAD GSN EI Y + GAQ +AP + R +A
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRY--IFGAQ-------------VAPATK----RLFA 304
Query: 581 LTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 640
L +TG++T+ ++LDRE T + + + ASDG + ATV I VTDVN
Sbjct: 305 LN-----------NTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVN 352
Query: 641 DNAPVFD-PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNL 691
DN P D Y+ P N +V E N + + +D D +NG+V + F+
Sbjct: 353 DNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLK 412
Query: 692 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 751
+ + T+ L+ E + +VA+D + T + +K+ D +DN P+F
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQP 472
Query: 752 TYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 811
+ V EN G + I A D D G N + FF L TG L+ R D
Sbjct: 473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 812 EAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVK 870
E +QE I F V A D GT P A V V V D ND P F+ ++ V+ + K
Sbjct: 533 E---EQERFI-FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
Query: 871 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 930
+ + + DAD A + D+ F ++ SG + + V+ + E +
Sbjct: 588 YSTVGVITVTDADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSS 640
Query: 931 FKLVVVAFDDGEPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVG 985
+ V A D G+P SS+A V I V+ P I + ++ P+S A G++V
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVA 698
Query: 986 VISAAAI----NQSIVYSIVSGNEEDTFGINNITGVI 1018
+ A + N + Y+IVSGN + F I+ +TG I
Sbjct: 699 EVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 179 bits (453), Expect = 3e-44
Identities = 185/649 (28%), Positives = 289/649 (44%), Gaps = 88/649 (13%)
Query: 495 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 554
+ I V D NDN P FP ++ + + +A D D G NG YE+L G Q
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QS 186
Query: 555 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYI 614
F G++++ P E+ ++ + + LDRE D Y+
Sbjct: 187 VF-------------GLDIV-------------ETPEGEKWPQLI-VQQNLDREQKDTYV 219
Query: 615 LIITASDG-RPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAFVGQV 668
+ I DG P +STA + + V+DVNDN PVF + ++P N V V Q+
Sbjct: 220 MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV-----GTSVIQL 274
Query: 669 KATDPDAGINGQVHYSLG-----NFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATD 722
ATD D G N ++ Y G LF + + + T + L+RE +++ V+A+D
Sbjct: 275 HATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 723 GAVHPRHSTLTLAIKVLDIDDNSP------VFTNSTYTVLVEENLPAGTTI--LQIEAKD 774
G+ P +T+T I V D++DN P + + TV + E P T I + + KD
Sbjct: 335 GSSTPARATVT--INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKD 392
Query: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 834
D+ V I H A++ L LDYE + +F + A D
Sbjct: 393 TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKE----FSFKIVASDSGKPS 448
Query: 835 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
A V V ++D ND PP+F++ + + V+ + +G +TT+ A D D G A V
Sbjct: 449 LNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDED-SGKNADIV-- 505
Query: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKIL 954
Q AS F+++ +G + + E F V A D+G P + S A V +
Sbjct: 506 ----YQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 955 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1009
VL + P+FT ++ VSE K + VGVI+ A N+++ SI+ N+ D F
Sbjct: 562 VLDENDNSPKFTHNHFQ-FFVSENLPKYSTVGVITVTDADAGENKAVTLSIL--NDNDNF 618
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
++ +GVI N D E ++SY V+A + P +S+TAKV I + D N++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKA-------TDGGQPPRSSTAKVTINVMDVNDN 671
Query: 1070 PPVF-----QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1113
PV F + V A + V V A D DTG + + Y ++
Sbjct: 672 SPVVISPPSNTSFKL--VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718
Score = 165 bits (418), Expect = 3e-40
Identities = 183/694 (26%), Positives = 296/694 (42%), Gaps = 103/694 (14%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPSP----VINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLAS-- 333
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 426
+G PA A + I + D N+ P + YI+ +P+ T+ D +N L I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDLR----YII--SPINGTVYLSEKDPVNTKIAL-I 386
Query: 427 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
DKD + + ++ F+ L +D E + ++F I A D
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
Query: 487 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
+ S + +V +++ D NDN P F + ++ V + R G + ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKA 604
Y++ G F +R TG+LT +
Sbjct: 505 VYQL--GPNASFF---------------------------------DLDRKTGVLTASRV 529
Query: 605 LDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVE 658
DRE +R+I +TA D G P S A V + V D NDN+P F ++ NL
Sbjct: 530 FDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL---- 585
Query: 659 EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELV 717
+ VG + TD DAG N V S+ N N+ F + +G I + V +RE + Y
Sbjct: 586 -PKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFD 644
Query: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAK 773
V ATDG PR ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A
Sbjct: 645 VKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAV 703
Query: 774 DVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 805
DVD G N + Y I S K F + P TG ++L
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Score = 109 bits (272), Expect = 3e-23
Identities = 117/487 (24%), Positives = 215/487 (44%), Gaps = 52/487 (10%)
Query: 713 YYELVVVATDGAVHPRHSTLTLAIKVL--DIDDNSPVFTNSTYTVLVEENLPAGTTILQI 770
++EL VV + P + IK++ D +DN+P+F + + + EN +
Sbjct: 110 FFELEVV-----ILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIP 164
Query: 771 EAKDVDLGANVSYRIRSPEVKHFFALH-PFTGELSLLRSLDYEAFP--------DQEASI 821
A D D G N V+H+ L+ L ++ + + E +P D+E
Sbjct: 165 SATDPDTGFN--------GVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKD 216
Query: 822 TFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 879
T++++ G P A + V V D+ND PVF + + + +A GT + ++A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 880 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 939
DAD + +RY P +F + +G + + +L+ E T I K+ V+A D
Sbjct: 277 TDADIGS--NAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 940 DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPV------SELATKGTMVGVISAAAIN 993
+ ATV I V + P Y P+ SE T + +I+ + +
Sbjct: 335 GSS--TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKD 392
Query: 994 QSIVYSIVSGNEEDT-FGINNITGVIYV---NGPLDYETRTSYVLRVQADSLEVVLANLR 1049
+ ++ E + F + + Y+ + LDYE + S ++V ++
Sbjct: 393 TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF-------SFKIVASDSG 445
Query: 1050 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1109
PS + TA V ++++DEN++PP+F + VSE+ R + + ATD+D+G + +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIV 505
Query: 1110 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1169
Y+L F ++ TG++ + +F + F F V A D+ L +A V+V
Sbjct: 506 YQL-----GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 1170 SVVNQLD 1176
+V+++ D
Sbjct: 561 TVLDEND 567
Score = 103 bits (257), Expect = 2e-21
Identities = 97/357 (27%), Positives = 150/357 (42%), Gaps = 38/357 (10%)
Query: 278 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 337 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + K L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 501
LND + +G+ + DRE+Q +YTF + A DG Q S V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
Query: 502 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
NDN+P P + V PG V ++ AVD D G N E+ Y I+ G +G F
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYI 614
I+ TG IT+ + L V +D P T +L D YI
Sbjct: 728 IDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYI 784
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ + Y+I+ G + F + P T ++L E
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739
Query: 373 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
P P GLH + I D T+ Y+ ++A + I D + T L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796
Query: 430 DKDIEDTKDP 439
D++I D+ P
Sbjct: 797 DRNIGDSSQP 806
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 202 bits (515), Expect = 2e-51
Identities = 173/603 (28%), Positives = 277/603 (45%), Gaps = 59/603 (9%)
Query: 632 VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNN 690
+ I+V D NDNAP+F P N+S+ E N+ ATDPD G NG HY L N +
Sbjct: 128 IKIIVKDTNDNAPMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 691 LFRI----TSNGSIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
+F + T G + + L+RE +D Y + + DG + ST L + V D++
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVN 246
Query: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALH 797
DN PVF V + EN P GT+++Q+ A D D+G+N R +P K FAL+
Sbjct: 247 DNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALN 306
Query: 798 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSK 857
TG +++ RSLD E + A V A D G+ P ATVT+ V D+ND PP
Sbjct: 307 NTTGLITVQRSLDRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDL 360
Query: 858 RIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASI 907
R +++P + G TVY + DP + + D ++ P +
Sbjct: 361 RY---IISP--ING----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHL 411
Query: 908 FEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE 967
V ++ + T L+ E T F +VA D G+P ++ +A V++ + + P +
Sbjct: 412 KAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQ 471
Query: 968 EYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1023
VSE +G + ISA + N IVY + G F ++ TGV+ +
Sbjct: 472 PVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRV 529
Query: 1024 LDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVS 1083
D E + ++ V A + P + A V + + DEN++ P F + VS
Sbjct: 530 FDREEQERFIFTVTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
Query: 1084 EDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMR 1143
E+ +++V + TD D G + ++ + FV++ Y+G+IK+ + F +
Sbjct: 583 ENLPKYSTVGVITVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQ 637
Query: 1144 RSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1203
+S + F V ATD S A V ++V++ D +V + PP+ K+ L+ I
Sbjct: 638 QSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSV 696
Query: 1204 VQE 1206
V E
Sbjct: 697 VAE 699
Score = 179 bits (455), Expect = 2e-44
Identities = 177/577 (30%), Positives = 263/577 (45%), Gaps = 66/577 (11%)
Query: 463 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 520
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 521 DMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYA 580
+ G SVIQL A DAD GSN EI Y + GAQ +AP + R +A
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRY--IFGAQ-------------VAPATK----RLFA 304
Query: 581 LTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 640
L +TG++T+ ++LDRE T + + + ASDG + ATV I VTDVN
Sbjct: 305 LN-----------NTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVN 352
Query: 641 DNAPVFD-PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNL 691
DN P D Y+ P N +V E N + + +D D +NG+V + F+
Sbjct: 353 DNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLK 412
Query: 692 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 751
+ + T+ L+ E + +VA+D + T + +K+ D +DN P+F
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQP 472
Query: 752 TYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDY 811
+ V EN G + I A D D G N + FF L TG L+ R D
Sbjct: 473 VIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDR 532
Query: 812 EAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVK 870
E +QE I F V A D GT P A V V V D ND P F+ ++ V+ + K
Sbjct: 533 E---EQERFI-FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPK 587
Query: 871 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 930
+ + + DAD A + D+ F ++ SG + + V+ + E +
Sbjct: 588 YSTVGVITVTDADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSS 640
Query: 931 FKLVVVAFDDGEPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVG 985
+ V A D G+P SS+A V I V+ P I + ++ P+S A G++V
Sbjct: 641 YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVA 698
Query: 986 VISAAAI----NQSIVYSIVSGNEEDTFGINNITGVI 1018
+ A + N + Y+IVSGN + F I+ +TG I
Sbjct: 699 EVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 179 bits (453), Expect = 3e-44
Identities = 185/649 (28%), Positives = 289/649 (44%), Gaps = 88/649 (13%)
Query: 495 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG 554
+ I V D NDN P FP ++ + + +A D D G NG YE+L G Q
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QS 186
Query: 555 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYI 614
F G++++ P E+ ++ + + LDRE D Y+
Sbjct: 187 VF-------------GLDIV-------------ETPEGEKWPQLI-VQQNLDREQKDTYV 219
Query: 615 LIITASDG-RPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAFVGQV 668
+ I DG P +STA + + V+DVNDN PVF + ++P N V V Q+
Sbjct: 220 MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPV-----GTSVIQL 274
Query: 669 KATDPDAGINGQVHYSLG-----NFNNLFRITSNGSIYTAVK-LNREVRDYYELVVVATD 722
ATD D G N ++ Y G LF + + + T + L+RE +++ V+A+D
Sbjct: 275 HATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 723 GAVHPRHSTLTLAIKVLDIDDNSP------VFTNSTYTVLVEENLPAGTTI--LQIEAKD 774
G+ P +T+T I V D++DN P + + TV + E P T I + + KD
Sbjct: 335 GSSTPARATVT--INVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKD 392
Query: 775 VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTM 834
D+ V I H A++ L LDYE + +F + A D
Sbjct: 393 TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKE----FSFKIVASDSGKPS 448
Query: 835 PPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
A V V ++D ND PP+F++ + + V+ + +G +TT+ A D D G A V
Sbjct: 449 LNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDED-SGKNADIV-- 505
Query: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKIL 954
Q AS F+++ +G + + E F V A D+G P + S A V +
Sbjct: 506 ----YQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 955 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1009
VL + P+FT ++ VSE K + VGVI+ A N+++ SI+ N+ D F
Sbjct: 562 VLDENDNSPKFTHNHFQ-FFVSENLPKYSTVGVITVTDADAGENKAVTLSIL--NDNDNF 618
Query: 1010 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1069
++ +GVI N D E ++SY V+A + P +S+TAKV I + D N++
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKA-------TDGGQPPRSSTAKVTINVMDVNDN 671
Query: 1070 PPVF-----QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1113
PV F + V A + V V A D DTG + + Y ++
Sbjct: 672 SPVVISPPSNTSFKL--VPLSAIPGSVVAEVFAVDVDTGMNAELKYTIV 718
Score = 165 bits (418), Expect = 3e-40
Identities = 183/694 (26%), Positives = 296/694 (42%), Gaps = 103/694 (14%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPSP----VINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLAS-- 333
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 426
+G PA A + I + D N+ P + YI+ +P+ T+ D +N L I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDLR----YII--SPINGTVYLSEKDPVNTKIAL-I 386
Query: 427 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
DKD + + ++ F+ L +D E + ++F I A D
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
Query: 487 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
+ S + +V +++ D NDN P F + ++ V + R G + ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKA 604
Y++ G F +R TG+LT +
Sbjct: 505 VYQL--GPNASFF---------------------------------DLDRKTGVLTASRV 529
Query: 605 LDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVE 658
DRE +R+I +TA D G P S A V + V D NDN+P F ++ NL
Sbjct: 530 FDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL---- 585
Query: 659 EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELV 717
+ VG + TD DAG N V S+ N N+ F + +G I + V +RE + Y
Sbjct: 586 -PKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFD 644
Query: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAK 773
V ATDG PR ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A
Sbjct: 645 VKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAV 703
Query: 774 DVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 805
DVD G N + Y I S K F + P TG ++L
Sbjct: 704 DVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL 737
Score = 109 bits (272), Expect = 3e-23
Identities = 117/487 (24%), Positives = 215/487 (44%), Gaps = 52/487 (10%)
Query: 713 YYELVVVATDGAVHPRHSTLTLAIKVL--DIDDNSPVFTNSTYTVLVEENLPAGTTILQI 770
++EL VV + P + IK++ D +DN+P+F + + + EN +
Sbjct: 110 FFELEVV-----ILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIP 164
Query: 771 EAKDVDLGANVSYRIRSPEVKHFFALH-PFTGELSLLRSLDYEAFP--------DQEASI 821
A D D G N V+H+ L+ L ++ + + E +P D+E
Sbjct: 165 SATDPDTGFN--------GVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKD 216
Query: 822 TFLVEAFDIYGTMP--PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 879
T++++ G P A + V V D+ND PVF + + + +A GT + ++A
Sbjct: 217 TYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHA 276
Query: 880 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 939
DAD + +RY P +F + +G + + +L+ E T I K+ V+A D
Sbjct: 277 TDADIGS--NAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASD 334
Query: 940 DGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPV------SELATKGTMVGVISAAAIN 993
+ ATV I V + P Y P+ SE T + +I+ + +
Sbjct: 335 GSS--TPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKD 392
Query: 994 QSIVYSIVSGNEEDT-FGINNITGVIYV---NGPLDYETRTSYVLRVQADSLEVVLANLR 1049
+ ++ E + F + + Y+ + LDYE + S ++V ++
Sbjct: 393 TDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEF-------SFKIVASDSG 445
Query: 1050 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1109
PS + TA V ++++DEN++PP+F + VSE+ R + + ATD+D+G + +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIV 505
Query: 1110 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1169
Y+L F ++ TG++ + +F + F F V A D+ L +A V+V
Sbjct: 506 YQL-----GPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 1170 SVVNQLD 1176
+V+++ D
Sbjct: 561 TVLDEND 567
Score = 103 bits (257), Expect = 2e-21
Identities = 97/357 (27%), Positives = 150/357 (42%), Gaps = 38/357 (10%)
Query: 278 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 337 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + K L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 501
LND + +G+ + DRE+Q +YTF + A DG Q S V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
Query: 502 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
NDN+P P + V PG V ++ AVD D G N E+ Y I+ G +G F
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYI 614
I+ TG IT+ + L V +D P T +L D YI
Sbjct: 728 IDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYI 784
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ + Y+I+ G + F + P T ++L E
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739
Query: 373 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
P P GLH + I D T+ Y+ ++A + I D + T L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796
Query: 430 DKDIEDTKDP 439
D++I D+ P
Sbjct: 797 DRNIGDSSQP 806
>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
[Homo sapiens]
Length = 1007
Score = 195 bits (496), Expect = 3e-49
Identities = 214/769 (27%), Positives = 338/769 (43%), Gaps = 106/769 (13%)
Query: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDF--HQKFDLVIKAEQDNGHPLPA 377
PG L +G P PR+ + + L + E ++R+ Q+ ++ E +P+ A
Sbjct: 74 PGCLRINHLGAPS--PRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPV-A 130
Query: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
+ + +EILD N+ SP F P+YQ + ES GA ++ S A D D+
Sbjct: 131 VSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARF----HIES-----AQDPDVGANS 181
Query: 438 DPELHLFLNDY--TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPV 493
L +++ + + + L L + +DRE+ + +TA DG S
Sbjct: 182 VQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTA 241
Query: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
++++V+D NDN+P F + +Y V + D PG V++L A D DEGSNGE+ Y L
Sbjct: 242 QISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYS-LSSYT 300
Query: 554 GD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRE 608
D F I+ +TG + + G++ +Y + VQA D P
Sbjct: 301 SDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMA-------------- 346
Query: 609 STDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVG 666
G V+IV DVNDNAP + L S V E A N V
Sbjct: 347 -----------------GHCKVLVDIV--DVNDNAP--EVVLTDLYSPVPENATPNTIVA 385
Query: 667 QVKATDPDAGINGQVHYSLGNFNNL-FRITSNGSIYTAV---KLNREVRDYYELVVVATD 722
+ D D+G N +V SLG L FR+ G+ YT V L+RE Y + V ATD
Sbjct: 386 VLSVNDQDSGPNRKV--SLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 723 GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD--LGAN 780
G + S TL +++ DI+DN P F +Y++ ++EN G + ++A D D A
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 781 VSYRIRSPEVK-----HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 835
V+Y + E++ + +++ +G L + S DYE F +E +T VEA D P
Sbjct: 504 VTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKF--REFFVT--VEAQD--KGSP 557
Query: 836 PGIATVT--VIVKDMND------YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 887
P +TVT V V DMND YP + MV A G +T V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSD---- 613
Query: 888 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS 947
+ + + + +F+VE +G + T + +E + F L VV D+GEP +S+
Sbjct: 614 -SGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSA 672
Query: 948 SATVKILVL-HPGEIPRFTQEEYRPPPVSELATKGTMVGV--ISAAAINQSIVYSIVSGN 1004
S + + V+ +I TQ + P T ++ + +S + I+ SI+
Sbjct: 673 SVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCY 732
Query: 1005 EEDTFG---INNITGV-------IYVNGPLDYETRTSYVLRVQADSLEV 1043
+G GV +Y + + R + L+VQ +EV
Sbjct: 733 RYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIEV 781
Score = 149 bits (375), Expect = 3e-35
Identities = 155/613 (25%), Positives = 254/613 (41%), Gaps = 55/613 (8%)
Query: 595 STGILTLGKALDREST----DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 650
++G L + + +DRE+ R +L + P S V I+ D+NDN+P F P
Sbjct: 95 TSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEIL--DINDNSPRF-PRP 151
Query: 651 PRNLSVVEEEANAFVGQVK-ATDPDAGINGQVHYSLGNFNN----LFRITSNGSIYTAVK 705
L V E A ++ A DPD G N Y L + L + N + V
Sbjct: 152 NYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVL 211
Query: 706 ---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 762
L+RE + LV+ A DG + R T ++++VLD +DNSP F STY V + E+ P
Sbjct: 212 RKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSP 271
Query: 763 AGTTILQIEAKDVDLGANVSYR-----IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 817
GT ++++ A D D G+N R S + F++ TGE+ ++ LDYE +
Sbjct: 272 PGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYE----E 327
Query: 818 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 877
+S V+A D G V V + D+ND P V +A T + +
Sbjct: 328 ASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVL 387
Query: 878 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 937
D D P +V + + P+ + F +S ++ L+ E ++ + V A
Sbjct: 388 SVNDQDSG--PNRKVSLGL-EATLPFRLNGF---GNSYTLVVSGPLDRERVAVYNITVTA 441
Query: 938 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AIN 993
D G P ++S T+K+ + + P E+ + E G ++ + A N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 994 QSIVYSIVSGNEE-----DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1048
+ YS++ + IN+ +G +Y DYE + + V+A +
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQ-------DK 554
Query: 1049 RVPSKSNTAKVYIEIQDENNHPPVF------QKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
P S+T + + D N+H P V A V +V A D D+
Sbjct: 555 GSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDS 614
Query: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
G + + Y L + F VE +TG I+T + S F V+ D+ LS
Sbjct: 615 GQNAWLFYHL---AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671
Query: 1163 GKADVLVSVVNQL 1175
+ V+VV+++
Sbjct: 672 ASVAITVAVVDRV 684
Score = 133 bits (334), Expect = 2e-30
Identities = 155/630 (24%), Positives = 258/630 (40%), Gaps = 103/630 (16%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + + D NDNSP F +Y V+E G A D D G N Y +
Sbjct: 134 VEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHI-----ESAQDPDVGANSVQTYEL- 187
Query: 193 YNPDDPTSNDTFEIPLM-LTGN-----IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ ++ FE+ L L N +VLRK L+ E + +++ A D R+
Sbjct: 188 ------SPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGG---IPARS 238
Query: 247 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 306
T ++V VLD +D P F TY+ +LR E+ P + + A
Sbjct: 239 GTAQISVRVLDTNDNSPAF------------DQSTYRV---QLR--EDSPPGTLVVKLNA 281
Query: 307 IDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
D D + YS+ T + + F + T E+ ++ ++ + + + ++
Sbjct: 282 SDPDE-----GSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQ 336
Query: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESA---PVGATISDSLNLTSP 423
A P+ + ++I+D N+ +P + + E+A + A +S + + P
Sbjct: 337 ATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGP 396
Query: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
R V+L +E T L+ F N YT L + P+DRE Y ++TA
Sbjct: 397 NRKVSL--GLEATLPFRLNGFGNSYT-------------LVVSGPLDRERVAVYNITVTA 441
Query: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
DG Q + + +++ D NDN P+F E SY +Y+ + PG + + A D DE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 542 GEITYEILVGAQGDFIINKTTGL-ITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
E+TY +L + GL +T + G YA+
Sbjct: 502 AEVTYSLLE--------REIQGLPVTSYVSINSASGSLYAV------------------- 534
Query: 601 LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDPYLPRNLSVVE 658
+ D E + + + A D G P +ST T N+ V D+ND+AP + P + + E
Sbjct: 535 --NSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFE 592
Query: 659 -----EEANAFVGQVKATDPDAGINGQVHYSLGNFN--NLFRI-TSNGSIYTAVKLNREV 710
A V +V A D D+G N + Y L + +LF++ G I T K+ E
Sbjct: 593 MVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDES 652
Query: 711 RDYYELVVVATDGAVHPRHSTLTLAIKVLD 740
+ L VV D +++ + + V+D
Sbjct: 653 GSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 90.5 bits (223), Expect = 1e-17
Identities = 120/523 (22%), Positives = 207/523 (39%), Gaps = 68/523 (13%)
Query: 103 LDRDPPMNIHSIVVQVQC-INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
LDR+ H ++ V I + GT ++ + V D NDNSP F +Y + E +P
Sbjct: 215 LDREQAALHHLVLTAVDGGIPARSGTA---QISVRVLDTNDNSPAFDQSTYRVQLREDSP 271
Query: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
GT + A+D D+G NG++ Y + D F I TG + + L+
Sbjct: 272 PGTLVV-----KLNASDPDEGSNGELRYSLSSYTSD-RERQLFSIDAS-TGEVRVIGGLD 324
Query: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
YE+ + Y + +QA DR + VD++D +D P
Sbjct: 325 YEEASSYQIYVQATDRGP---VPMAGHCKVLVDIVDVNDNAP------------------ 363
Query: 282 YQAAIPELRT--PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
+ + +L + PE P + + DQD G + +G P +
Sbjct: 364 -EVVLTDLYSPVPENATPNTIVAVLSVNDQD---------SGPNRKVSLGLEATLPFRLN 413
Query: 340 MHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
+ L + P++R+ +++ + A L + L +EI D N+ P F S
Sbjct: 414 GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDS 473
Query: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Y YI E+ G + + A D D ++ + L + + + I
Sbjct: 474 YSIYIQENNLPGVLL---------CTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSI 524
Query: 460 ---TRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTP--TFPEI 512
+ L + D E+ + + ++ A D S V N+ V+D ND+ P +P
Sbjct: 525 NSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTS 584
Query: 513 SYDVYVYTDMRP-----GDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT 566
+ + +M P G V ++ A+D+D G N + Y + + D F + TG I
Sbjct: 585 TNSSAAF-EMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIR 643
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRES 609
+ G T+ LTV DN P+ ++ +T+ +DR S
Sbjct: 644 TTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA-VVDRVS 685
Score = 65.5 bits (158), Expect = 5e-10
Identities = 80/344 (23%), Positives = 143/344 (41%), Gaps = 40/344 (11%)
Query: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEE------PTTIFKLVVVAFDDGEPVMSSS 948
R++ + P P + E++ SG + ++ E P + L V+A + PV S+
Sbjct: 78 RINHLGAPSPRYL-ELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHN---PVAVSA 133
Query: 949 ATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1008
V+IL ++ PRF + Y+ VSE G + SA + V N T
Sbjct: 134 VEVEILDINDNS-PRFPRPNYQLQ-VSESVAPGARFHIESAQDPD-------VGANSVQT 184
Query: 1009 FGINNITGVIYVNGPLDYETRT-SYVLRVQADSLEVVLANL-------RVPSKSNTAKVY 1060
+ ++ PL ++ VLR D + L +L +P++S TA++
Sbjct: 185 YELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQIS 244
Query: 1061 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1120
+ + D N++ P F + Y + ED+ T V+++ A+D D G+ + Y L
Sbjct: 245 VRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRE 304
Query: 1121 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1180
++ F ++ TG ++ S ++ V ATD ++G VLV +V+ D
Sbjct: 305 RQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVND---- 360
Query: 1181 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1224
N P + LT++ + P V V S+ + G
Sbjct: 361 --NAPEVV-------LTDLYSPVPENATPNTIVAVLSVNDQDSG 395
>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
[Homo sapiens]
Length = 884
Score = 195 bits (496), Expect = 3e-49
Identities = 214/769 (27%), Positives = 338/769 (43%), Gaps = 106/769 (13%)
Query: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDF--HQKFDLVIKAEQDNGHPLPA 377
PG L +G P PR+ + + L + E ++R+ Q+ ++ E +P+ A
Sbjct: 74 PGCLRINHLGAPS--PRYLELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPV-A 130
Query: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
+ + +EILD N+ SP F P+YQ + ES GA ++ S A D D+
Sbjct: 131 VSAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARF----HIES-----AQDPDVGANS 181
Query: 438 DPELHLFLNDY--TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPV 493
L +++ + + + L L + +DRE+ + +TA DG S
Sbjct: 182 VQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTA 241
Query: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
++++V+D NDN+P F + +Y V + D PG V++L A D DEGSNGE+ Y L
Sbjct: 242 QISVRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYS-LSSYT 300
Query: 554 GD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRE 608
D F I+ +TG + + G++ +Y + VQA D P
Sbjct: 301 SDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMA-------------- 346
Query: 609 STDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVG 666
G V+IV DVNDNAP + L S V E A N V
Sbjct: 347 -----------------GHCKVLVDIV--DVNDNAP--EVVLTDLYSPVPENATPNTIVA 385
Query: 667 QVKATDPDAGINGQVHYSLGNFNNL-FRITSNGSIYTAV---KLNREVRDYYELVVVATD 722
+ D D+G N +V SLG L FR+ G+ YT V L+RE Y + V ATD
Sbjct: 386 VLSVNDQDSGPNRKV--SLGLEATLPFRLNGFGNSYTLVVSGPLDRERVAVYNITVTATD 443
Query: 723 GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD--LGAN 780
G + S TL +++ DI+DN P F +Y++ ++EN G + ++A D D A
Sbjct: 444 GGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKENAE 503
Query: 781 VSYRIRSPEVK-----HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 835
V+Y + E++ + +++ +G L + S DYE F +E +T VEA D P
Sbjct: 504 VTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKF--REFFVT--VEAQD--KGSP 557
Query: 836 PGIATVT--VIVKDMND------YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 887
P +TVT V V DMND YP + MV A G +T V A D+D
Sbjct: 558 PLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSD---- 613
Query: 888 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS 947
+ + + + +F+VE +G + T + +E + F L VV D+GEP +S+
Sbjct: 614 -SGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLSA 672
Query: 948 SATVKILVL-HPGEIPRFTQEEYRPPPVSELATKGTMVGV--ISAAAINQSIVYSIVSGN 1004
S + + V+ +I TQ + P T ++ + +S + I+ SI+
Sbjct: 673 SVAITVAVVDRVSKILPDTQRHVKSPRTYSEITLYLIIALSTVSFIFLLTIIILSIIKCY 732
Query: 1005 EEDTFG---INNITGV-------IYVNGPLDYETRTSYVLRVQADSLEV 1043
+G GV +Y + + R + L+VQ +EV
Sbjct: 733 RYTAYGTACCGGFCGVRERSPAELYKQANNNIDARIPHGLKVQPHFIEV 781
Score = 149 bits (375), Expect = 3e-35
Identities = 155/613 (25%), Positives = 254/613 (41%), Gaps = 55/613 (8%)
Query: 595 STGILTLGKALDREST----DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 650
++G L + + +DRE+ R +L + P S V I+ D+NDN+P F P
Sbjct: 95 TSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSAVEVEIL--DINDNSPRF-PRP 151
Query: 651 PRNLSVVEEEANAFVGQVK-ATDPDAGINGQVHYSLGNFNN----LFRITSNGSIYTAVK 705
L V E A ++ A DPD G N Y L + L + N + V
Sbjct: 152 NYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVL 211
Query: 706 ---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 762
L+RE + LV+ A DG + R T ++++VLD +DNSP F STY V + E+ P
Sbjct: 212 RKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSPAFDQSTYRVQLREDSP 271
Query: 763 AGTTILQIEAKDVDLGANVSYR-----IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 817
GT ++++ A D D G+N R S + F++ TGE+ ++ LDYE +
Sbjct: 272 PGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYE----E 327
Query: 818 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 877
+S V+A D G V V + D+ND P V +A T + +
Sbjct: 328 ASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVL 387
Query: 878 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 937
D D P +V + + P+ + F +S ++ L+ E ++ + V A
Sbjct: 388 SVNDQDSG--PNRKVSLGL-EATLPFRLNGF---GNSYTLVVSGPLDRERVAVYNITVTA 441
Query: 938 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AIN 993
D G P ++S T+K+ + + P E+ + E G ++ + A N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 994 QSIVYSIVSGNEE-----DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1048
+ YS++ + IN+ +G +Y DYE + + V+A +
Sbjct: 502 AEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQ-------DK 554
Query: 1049 RVPSKSNTAKVYIEIQDENNHPPVF------QKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
P S+T + + D N+H P V A V +V A D D+
Sbjct: 555 GSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTKVIAMDSDS 614
Query: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
G + + Y L + F VE +TG I+T + S F V+ D+ LS
Sbjct: 615 GQNAWLFYHL---AQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNGEPSLS 671
Query: 1163 GKADVLVSVVNQL 1175
+ V+VV+++
Sbjct: 672 ASVAITVAVVDRV 684
Score = 133 bits (334), Expect = 2e-30
Identities = 155/630 (24%), Positives = 258/630 (40%), Gaps = 103/630 (16%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + + D NDNSP F +Y V+E G A D D G N Y +
Sbjct: 134 VEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHI-----ESAQDPDVGANSVQTYEL- 187
Query: 193 YNPDDPTSNDTFEIPLM-LTGN-----IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ ++ FE+ L L N +VLRK L+ E + +++ A D R+
Sbjct: 188 ------SPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGG---IPARS 238
Query: 247 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 306
T ++V VLD +D P F TY+ +LR E+ P + + A
Sbjct: 239 GTAQISVRVLDTNDNSPAF------------DQSTYRV---QLR--EDSPPGTLVVKLNA 281
Query: 307 IDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
D D + YS+ T + + F + T E+ ++ ++ + + + ++
Sbjct: 282 SDPDE-----GSNGELRYSLSSYTSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQ 336
Query: 367 AEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESA---PVGATISDSLNLTSP 423
A P+ + ++I+D N+ +P + + E+A + A +S + + P
Sbjct: 337 ATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGP 396
Query: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
R V+L +E T L+ F N YT L + P+DRE Y ++TA
Sbjct: 397 NRKVSL--GLEATLPFRLNGFGNSYT-------------LVVSGPLDRERVAVYNITVTA 441
Query: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
DG Q + + +++ D NDN P+F E SY +Y+ + PG + + A D DE N
Sbjct: 442 TDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGVLLCTVQATDPDEKEN 501
Query: 542 GEITYEILVGAQGDFIINKTTGL-ITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
E+TY +L + GL +T + G YA+
Sbjct: 502 AEVTYSLLE--------REIQGLPVTSYVSINSASGSLYAV------------------- 534
Query: 601 LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDPYLPRNLSVVE 658
+ D E + + + A D G P +ST T N+ V D+ND+AP + P + + E
Sbjct: 535 --NSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFE 592
Query: 659 -----EEANAFVGQVKATDPDAGINGQVHYSLGNFN--NLFRI-TSNGSIYTAVKLNREV 710
A V +V A D D+G N + Y L + +LF++ G I T K+ E
Sbjct: 593 MVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDES 652
Query: 711 RDYYELVVVATDGAVHPRHSTLTLAIKVLD 740
+ L VV D +++ + + V+D
Sbjct: 653 GSTFNLTVVVRDNGEPSLSASVAITVAVVD 682
Score = 90.5 bits (223), Expect = 1e-17
Identities = 120/523 (22%), Positives = 207/523 (39%), Gaps = 68/523 (13%)
Query: 103 LDRDPPMNIHSIVVQVQC-INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
LDR+ H ++ V I + GT ++ + V D NDNSP F +Y + E +P
Sbjct: 215 LDREQAALHHLVLTAVDGGIPARSGTA---QISVRVLDTNDNSPAFDQSTYRVQLREDSP 271
Query: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
GT + A+D D+G NG++ Y + D F I TG + + L+
Sbjct: 272 PGTLVV-----KLNASDPDEGSNGELRYSLSSYTSD-RERQLFSIDAS-TGEVRVIGGLD 324
Query: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
YE+ + Y + +QA DR + VD++D +D P
Sbjct: 325 YEEASSYQIYVQATDRGP---VPMAGHCKVLVDIVDVNDNAP------------------ 363
Query: 282 YQAAIPELRT--PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
+ + +L + PE P + + DQD G + +G P +
Sbjct: 364 -EVVLTDLYSPVPENATPNTIVAVLSVNDQD---------SGPNRKVSLGLEATLPFRLN 413
Query: 340 MHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
+ L + P++R+ +++ + A L + L +EI D N+ P F S
Sbjct: 414 GFGNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDS 473
Query: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Y YI E+ G + + A D D ++ + L + + + I
Sbjct: 474 YSIYIQENNLPGVLL---------CTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSI 524
Query: 460 ---TRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTP--TFPEI 512
+ L + D E+ + + ++ A D S V N+ V+D ND+ P +P
Sbjct: 525 NSASGSLYAVNSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTS 584
Query: 513 SYDVYVYTDMRP-----GDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT 566
+ + +M P G V ++ A+D+D G N + Y + + D F + TG I
Sbjct: 585 TNSSAAF-EMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIR 643
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRES 609
+ G T+ LTV DN P+ ++ +T+ +DR S
Sbjct: 644 TTRKMGDESGSTFNLTVVVRDNGEPSLSASVAITVA-VVDRVS 685
Score = 65.5 bits (158), Expect = 5e-10
Identities = 80/344 (23%), Positives = 143/344 (41%), Gaps = 40/344 (11%)
Query: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEE------PTTIFKLVVVAFDDGEPVMSSS 948
R++ + P P + E++ SG + ++ E P + L V+A + PV S+
Sbjct: 78 RINHLGAPSPRYL-ELDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHN---PVAVSA 133
Query: 949 ATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1008
V+IL ++ PRF + Y+ VSE G + SA + V N T
Sbjct: 134 VEVEILDINDNS-PRFPRPNYQLQ-VSESVAPGARFHIESAQDPD-------VGANSVQT 184
Query: 1009 FGINNITGVIYVNGPLDYETRT-SYVLRVQADSLEVVLANL-------RVPSKSNTAKVY 1060
+ ++ PL ++ VLR D + L +L +P++S TA++
Sbjct: 185 YELSPSEHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQIS 244
Query: 1061 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1120
+ + D N++ P F + Y + ED+ T V+++ A+D D G+ + Y L
Sbjct: 245 VRVLDTNDNSPAFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRE 304
Query: 1121 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1180
++ F ++ TG ++ S ++ V ATD ++G VLV +V+ D
Sbjct: 305 RQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVND---- 360
Query: 1181 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1224
N P + LT++ + P V V S+ + G
Sbjct: 361 --NAPEVV-------LTDLYSPVPENATPNTIVAVLSVNDQDSG 395
>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
Length = 1101
Score = 194 bits (494), Expect = 5e-49
Identities = 201/713 (28%), Positives = 308/713 (43%), Gaps = 145/713 (20%)
Query: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATIS-DSLNLTSPLRIVALDKDIEDTKDP 439
+ +EI D N+ +P F + I E+A G I DS A D D
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDS----------AYDPDSGSFGVQ 164
Query: 440 ELHLFLNDYTSVFTVTQTGITRYLTLL--QPVDREEQQTYTFSITAFDGVQESE--PVIV 495
L N+ + T+ +R+ L+ + +DRE Q Y+F ITA DG V +
Sbjct: 165 TYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGL 224
Query: 496 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 555
+I+V D+NDN P F E +Y V V + P VI+L A D DEG+NG++ Y G D
Sbjct: 225 SIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYS-FYGYVND 283
Query: 556 -----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610
F I+ +GL+T+ ++ G Y L VQA D P +
Sbjct: 284 RTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSI----------------- 326
Query: 611 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVG 666
+ V + V D NDN PV + L N +VE +A +
Sbjct: 327 ----------------PAHCKVTVSVLDTNDNPPVIN-LLSVNSELVEVSESAPPGYVIA 369
Query: 667 QVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV---KLNREVRDYYELVVVATDG 723
V+ +D D+G+NG+V L N FR+ S T + +L+RE D Y L + A DG
Sbjct: 370 LVRVSDRDSGLNGRVQCRLLG-NVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDG 428
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--V 781
V S + + + D +DN P F+ Y V+V+EN G +L + A+D DLG N V
Sbjct: 429 GVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSV 488
Query: 782 SYRIRSPEVKH-----FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 835
SY+I +V+ + +++P +G++ LRS ++E Q + F V A D G +P
Sbjct: 489 SYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHE----QTKAFEFKVLAKD--GGLPS 542
Query: 836 -PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP-------------ITTVYAED 881
ATV VI+ D+ND PV + AP + GT +T V AED
Sbjct: 543 LQSNATVRVIILDVNDNTPV--------ITAPPLINGTAEVYIPRNSGIGYLVTVVKAED 594
Query: 882 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 941
D RV Y + + FE+++ +G V T E + ++L+VVA D G
Sbjct: 595 YDEG--ENGRVTYDMTEGD----RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHG 648
Query: 942 EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1001
+ +S+SA V I Y P + + G ++N S+++ I
Sbjct: 649 KTSLSASALVLI---------------YLSPALDAQESMG---------SVNLSLIFIIA 684
Query: 1002 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1054
G +I G+++V T ++ + D+ E+ N R+ S
Sbjct: 685 LG---------SIAGILFV-------TMIFVAIKCKRDNKEIRTYNCRIAEYS 721
Score = 163 bits (413), Expect = 1e-39
Identities = 173/629 (27%), Positives = 271/629 (43%), Gaps = 59/629 (9%)
Query: 595 STGILTLGKALDRESTDRYI-LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 653
S+G+L + +DR+ R I + + + + + D+NDNAP F P
Sbjct: 77 SSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSF-PAAQIE 135
Query: 654 LSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLF----RITSNGSIYTAV---- 704
L + E + + A DPD+G G Y L N LF + +GS + +
Sbjct: 136 LEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTP-NELFGLEIKTRGDGSRFAELVVEK 194
Query: 705 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 764
L+RE + +Y + A DG PR T+ L+IKV D +DN+PVF+ STY V V EN P
Sbjct: 195 SLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPN 254
Query: 765 TTILQIEAKDVDLGANVS-----YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 819
T ++++ A D D G N Y + + F + P +G +++ +LDYE E
Sbjct: 255 TPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYEL 314
Query: 820 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG---MVAPDAVKGTPITT 876
V+A D+ P VTV V D ND PPV + V+ A G I
Sbjct: 315 D----VQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIAL 370
Query: 877 VYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 935
V D D GL RV+ R + +V F + E ++ L+ E + L +
Sbjct: 371 VRVSDRD-SGL-NGRVQCRLLGNVPFR-----LQEYESFSTILVDGRLDREQHDQYNLTI 423
Query: 936 VAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AA 991
A D G P++ S+ + +L+ + + Y V E T G + +SA
Sbjct: 424 QARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLG 483
Query: 992 INQSIVYSIVSGNEEDT-----FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1046
+N S+ Y IV D IN +G IY ++E + +A +V+
Sbjct: 484 LNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHE-------QTKAFEFKVLAK 536
Query: 1047 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE-----DARMFTSVLRVKATDKD 1101
+ +PS + A V + I D N++ PV I G +E ++ + V VKA D D
Sbjct: 537 DGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYD 596
Query: 1102 TGNYSVMAYRLIIPPIKEGKEGFV-VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1160
G + Y + EG GF ++ G ++T F +S ++ V+A D
Sbjct: 597 EGENGRVTY-----DMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTS 651
Query: 1161 LSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
LS A VL+ + LD Q + +V +L+
Sbjct: 652 LSASALVLIYLSPALDAQESMGSVNLSLI 680
Score = 149 bits (376), Expect = 3e-35
Identities = 161/582 (27%), Positives = 243/582 (41%), Gaps = 82/582 (14%)
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
E ++ +++ D NDN P+FP ++ + PG + +A D D GS G TYE+
Sbjct: 111 EICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTP 170
Query: 551 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610
N+ GL G D + AE L + K+LDRE+
Sbjct: 171 --------NELFGLEIKTRG----------------DGSRFAE-----LVVEKSLDRETQ 201
Query: 611 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVK 669
Y ITA D G P T ++I VTD NDN PVF N V ++
Sbjct: 202 SHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLN 261
Query: 670 ATDPDAGINGQVHYSLGNFNN-----LFRITSNGSIYTAV-KLNREVRDYYELVVVATDG 723
A+DPD G NGQV YS + N LF+I + + T L+ E YEL V A D
Sbjct: 262 ASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDL 321
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 780
+ + + + VLD +DN PV + ++ V V E+ P G I + D D G N
Sbjct: 322 GPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLN 381
Query: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP----------DQEASITFLVEAFDI 830
+ R PF R +YE+F +Q ++A D
Sbjct: 382 GRVQCR------LLGNVPF-------RLQEYESFSTILVDGRLDREQHDQYNLTIQARDG 428
Query: 831 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 890
M + TV++ D ND P FSK Y+ +V + G + +V A D D GL S
Sbjct: 429 GVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPD-LGLNGS 487
Query: 891 RVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 948
V Y++ V+ + + +SG + + N E T F+ V+A D G P + S+
Sbjct: 488 -VSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSN 546
Query: 949 ATVKILVLHPGEIPRFTQEEYRPPPVSELATK--------GTMVGVISA----AAINQSI 996
ATV++++L ++ T PP ++ A G +V V+ A N +
Sbjct: 547 ATVRVIIL---DVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
Query: 997 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
Y + G + F I+ + G + +++SY L V A
Sbjct: 604 TYDMTEG-DRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVA 644
Score = 136 bits (343), Expect = 2e-31
Identities = 152/561 (27%), Positives = 234/561 (41%), Gaps = 92/561 (16%)
Query: 281 TYQAAIPELRTPEELNPIIVTPPIQAIDQDRN---IQPPSDRPGILYSILVGTPEDYPRF 337
++ AA EL E +P P A D D +Q P L+ + + T D RF
Sbjct: 128 SFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRF 187
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
AEL + + ++R+ + I A P GL I++ D N+ +P F+
Sbjct: 188 -------AELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF---LNDYT-SVFT 453
+Y + E++P T +R+ A D D E T ++ F +ND T +F
Sbjct: 241 STYAVSVPENSPPN---------TPVIRLNASDPD-EGTNGQVVYSFYGYVNDRTRELFQ 290
Query: 454 V-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV--IVNIQVMDANDNTPTFP 510
+ +G+ +T+ +D EE Y + A D S P V + V+D NDN P
Sbjct: 291 IDPHSGL---VTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVIN 347
Query: 511 EISYD---VYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI 567
+S + V V PG + + D D G NG + +L F + + TI
Sbjct: 348 LLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLL--GNVPFRLQEYESFSTI 405
Query: 568 APGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGR-PDG 626
++ GR LDRE D+Y L I A DG P
Sbjct: 406 -----LVDGR---------------------------LDREQHDQYNLTIQARDGGVPML 433
Query: 627 TSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEAN---AFVGQVKATDPDAGINGQVH 682
S + +++TD NDN P F PY V+ +E N A++ V A DPD G+NG V
Sbjct: 434 QSAKSFTVLITDENDNHPHFSKPY----YQVIVQENNTPGAYLLSVSARDPDLGLNGSVS 489
Query: 683 Y--------SLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTL 734
Y + F + ++G IY N E +E V+A DG + S T+
Sbjct: 490 YQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATV 549
Query: 735 AIKVLDIDDNSPVFT-----NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRS 787
+ +LD++DN+PV T N T V + N G + ++A+D D G N V+Y +
Sbjct: 550 RVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTE 609
Query: 788 PEVKHFFALHPFTGELSLLRS 808
+ + FF + GE+ R+
Sbjct: 610 GD-RGFFEIDQVNGEVRTTRT 629
Score = 135 bits (341), Expect = 3e-31
Identities = 174/713 (24%), Positives = 291/713 (40%), Gaps = 129/713 (18%)
Query: 45 AIDEESRNGTILVDNMLIKGTAG-GPDPTIELSLK---DNVDYWVLMDPVKQMLFLNSTG 100
+++EE R GT++ + AG DP + + ++ + V ++P +L T
Sbjct: 28 SVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLV---TK 84
Query: 101 RVLDRD-----PPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
+ +DRD P I S+ V + V +++ ++D NDN+P+F
Sbjct: 85 QKIDRDLLCRQSPKCIISLEVMSSSMEICV-------IKVEIKDLNDNAPSFPAAQIELE 137
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN-- 213
++E GT I + A D D G G Y + T N+ F + + G+
Sbjct: 138 ISEAASPGTRIPL-----DSAYDPDSGSFGVQTYEL-------TPNELFGLEIKTRGDGS 185
Query: 214 ----IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
+V+ K L+ E ++ Y I A D + R T L++ V D +D P+F
Sbjct: 186 RFAELVVEKSLDRETQSHYSFRITALDGG---DPPRLGTVGLSIKVTDSNDNNPVF---- 238
Query: 270 LVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVG 329
TY ++PE P P+I + A D D ++YS
Sbjct: 239 --------SESTYAVSVPENSPPN--TPVI---RLNASDPDEGTNGQ-----VVYSFYGY 280
Query: 330 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDEN 389
+ F + P + +++ ++ + ++L ++A+ + +PA + + +LD N
Sbjct: 281 VNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTN 340
Query: 390 NQSPYFTMPSYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 446
+ P + S ++ ESAP G I +L S R L+ ++ + L
Sbjct: 341 DNPPVINLLSVNSELVEVSESAPPGYVI--ALVRVSD-RDSGLNGRVQCRLLGNVPFRLQ 397
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG----VQESEPVIVNIQVMDA 502
+Y S T+ G +DRE+ Y +I A DG +Q ++ + + D
Sbjct: 398 EYESFSTILVDG---------RLDREQHDQYNLTIQARDGGVPMLQSAKS--FTVLITDE 446
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 562
NDN P F + Y V V + PG ++ ++A D D G NG ++Y+I+ D +
Sbjct: 447 NDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPV---F 503
Query: 563 GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD- 621
++I P G YAL ++ + E T + + A D
Sbjct: 504 TYVSINPN----SGDIYAL---------------------RSFNHEQTKAFEFKVLAKDG 538
Query: 622 GRPDGTSTATVNIVVTDVNDNAPVF----------DPYLPRNLSVVEEEANAFVGQVKAT 671
G P S ATV +++ DVNDN PV + Y+PRN + V VKA
Sbjct: 539 GLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGI-----GYLVTVVKAE 593
Query: 672 DPDAGINGQVHYSLGNFN-NLFRITS-NGSIYTAVKLNREVRDYYELVVVATD 722
D D G NG+V Y + + F I NG + T + YEL+VVA D
Sbjct: 594 DYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHD 646
Score = 108 bits (270), Expect = 5e-23
Identities = 124/500 (24%), Positives = 218/500 (43%), Gaps = 59/500 (11%)
Query: 124 KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 183
++GT+ + I V D NDN+P F +Y +V E +P T + A+D D+G
Sbjct: 218 RLGTV---GLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIR-----LNASDPDEGT 269
Query: 184 NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 243
NGQ+ Y +D T + F+I +G + + L+YE+ Y + +QA D N
Sbjct: 270 NGQVVYSFYGYVNDRT-RELFQIDPH-SGLVTVTGALDYEEGHVYELDVQAKDLGPNSIP 327
Query: 244 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 303
+TV VLD +D P+ L+ + + E+ E P V
Sbjct: 328 AHCK---VTVSVLDTNDNPPVI------------NLLSVNSELVEVS--ESAPPGYVIAL 370
Query: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
++ D+D + G + L+G + P + + + + ++R+ H +++L
Sbjct: 371 VRVSDRDSGLN------GRVQCRLLG---NVPFRLQEYESFSTILVDGRLDREQHDQYNL 421
Query: 364 VIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
I+A +D G P L + + I DEN+ P+F+ P YQ + E+ GA +
Sbjct: 422 TIQA-RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL-------- 472
Query: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI---TRYLTLLQPVDREEQQTYTF 479
L + A D D+ + + + T I + + L+ + E+ + + F
Sbjct: 473 -LSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEF 531
Query: 480 SITAFDGVQES--EPVIVNIQVMDANDNTP--TFPEI---SYDVYVYTDMRPGDSVIQLT 532
+ A DG S V + ++D NDNTP T P + + +VY+ + G V +
Sbjct: 532 KVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVK 591
Query: 533 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
A D DEG NG +TY++ G +G F I++ G + +Y L V A D+ +
Sbjct: 592 AEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTS 651
Query: 593 ERSTG--ILTLGKALDREST 610
++ ++ L ALD + +
Sbjct: 652 LSASALVLIYLSPALDAQES 671
>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
Length = 1100
Score = 194 bits (494), Expect = 5e-49
Identities = 201/713 (28%), Positives = 308/713 (43%), Gaps = 145/713 (20%)
Query: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATIS-DSLNLTSPLRIVALDKDIEDTKDP 439
+ +EI D N+ +P F + I E+A G I DS A D D
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDS----------AYDPDSGSFGVQ 164
Query: 440 ELHLFLNDYTSVFTVTQTGITRYLTLL--QPVDREEQQTYTFSITAFDGVQESE--PVIV 495
L N+ + T+ +R+ L+ + +DRE Q Y+F ITA DG V +
Sbjct: 165 TYELTPNELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGL 224
Query: 496 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 555
+I+V D+NDN P F E +Y V V + P VI+L A D DEG+NG++ Y G D
Sbjct: 225 SIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYS-FYGYVND 283
Query: 556 -----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610
F I+ +GL+T+ ++ G Y L VQA D P +
Sbjct: 284 RTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSI----------------- 326
Query: 611 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVG 666
+ V + V D NDN PV + L N +VE +A +
Sbjct: 327 ----------------PAHCKVTVSVLDTNDNPPVIN-LLSVNSELVEVSESAPPGYVIA 369
Query: 667 QVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV---KLNREVRDYYELVVVATDG 723
V+ +D D+G+NG+V L N FR+ S T + +L+RE D Y L + A DG
Sbjct: 370 LVRVSDRDSGLNGRVQCRLLG-NVPFRLQEYESFSTILVDGRLDREQHDQYNLTIQARDG 428
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--V 781
V S + + + D +DN P F+ Y V+V+EN G +L + A+D DLG N V
Sbjct: 429 GVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSV 488
Query: 782 SYRIRSPEVKH-----FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP- 835
SY+I +V+ + +++P +G++ LRS ++E Q + F V A D G +P
Sbjct: 489 SYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHE----QTKAFEFKVLAKD--GGLPS 542
Query: 836 -PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP-------------ITTVYAED 881
ATV VI+ D+ND PV + AP + GT +T V AED
Sbjct: 543 LQSNATVRVIILDVNDNTPV--------ITAPPLINGTAEVYIPRNSGIGYLVTVVKAED 594
Query: 882 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 941
D RV Y + + FE+++ +G V T E + ++L+VVA D G
Sbjct: 595 YDEG--ENGRVTYDMTEGD----RGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHG 648
Query: 942 EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1001
+ +S+SA V I Y P + + G ++N S+++ I
Sbjct: 649 KTSLSASALVLI---------------YLSPALDAQESMG---------SVNLSLIFIIA 684
Query: 1002 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1054
G +I G+++V T ++ + D+ E+ N R+ S
Sbjct: 685 LG---------SIAGILFV-------TMIFVAIKCKRDNKEIRTYNCRIAEYS 721
Score = 163 bits (413), Expect = 1e-39
Identities = 173/629 (27%), Positives = 271/629 (43%), Gaps = 59/629 (9%)
Query: 595 STGILTLGKALDRESTDRYI-LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 653
S+G+L + +DR+ R I + + + + + D+NDNAP F P
Sbjct: 77 SSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKDLNDNAPSF-PAAQIE 135
Query: 654 LSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLF----RITSNGSIYTAV---- 704
L + E + + A DPD+G G Y L N LF + +GS + +
Sbjct: 136 LEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTP-NELFGLEIKTRGDGSRFAELVVEK 194
Query: 705 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 764
L+RE + +Y + A DG PR T+ L+IKV D +DN+PVF+ STY V V EN P
Sbjct: 195 SLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPN 254
Query: 765 TTILQIEAKDVDLGANVS-----YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 819
T ++++ A D D G N Y + + F + P +G +++ +LDYE E
Sbjct: 255 TPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYEL 314
Query: 820 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG---MVAPDAVKGTPITT 876
V+A D+ P VTV V D ND PPV + V+ A G I
Sbjct: 315 D----VQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIAL 370
Query: 877 VYAEDADPPGLPASRVRYR-VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 935
V D D GL RV+ R + +V F + E ++ L+ E + L +
Sbjct: 371 VRVSDRD-SGL-NGRVQCRLLGNVPFR-----LQEYESFSTILVDGRLDREQHDQYNLTI 423
Query: 936 VAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AA 991
A D G P++ S+ + +L+ + + Y V E T G + +SA
Sbjct: 424 QARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLG 483
Query: 992 INQSIVYSIVSGNEEDT-----FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA 1046
+N S+ Y IV D IN +G IY ++E + +A +V+
Sbjct: 484 LNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHE-------QTKAFEFKVLAK 536
Query: 1047 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE-----DARMFTSVLRVKATDKD 1101
+ +PS + A V + I D N++ PV I G +E ++ + V VKA D D
Sbjct: 537 DGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYD 596
Query: 1102 TGNYSVMAYRLIIPPIKEGKEGFV-VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1160
G + Y + EG GF ++ G ++T F +S ++ V+A D
Sbjct: 597 EGENGRVTY-----DMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTS 651
Query: 1161 LSGKADVLVSVVNQLDMQVIVSNVPPTLV 1189
LS A VL+ + LD Q + +V +L+
Sbjct: 652 LSASALVLIYLSPALDAQESMGSVNLSLI 680
Score = 149 bits (376), Expect = 3e-35
Identities = 161/582 (27%), Positives = 243/582 (41%), Gaps = 82/582 (14%)
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
E ++ +++ D NDN P+FP ++ + PG + +A D D GS G TYE+
Sbjct: 111 EICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTP 170
Query: 551 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610
N+ GL G D + AE L + K+LDRE+
Sbjct: 171 --------NELFGLEIKTRG----------------DGSRFAE-----LVVEKSLDRETQ 201
Query: 611 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVK 669
Y ITA D G P T ++I VTD NDN PVF N V ++
Sbjct: 202 SHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLN 261
Query: 670 ATDPDAGINGQVHYSLGNFNN-----LFRITSNGSIYTAV-KLNREVRDYYELVVVATDG 723
A+DPD G NGQV YS + N LF+I + + T L+ E YEL V A D
Sbjct: 262 ASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDL 321
Query: 724 AVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 780
+ + + + VLD +DN PV + ++ V V E+ P G I + D D G N
Sbjct: 322 GPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLN 381
Query: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP----------DQEASITFLVEAFDI 830
+ R PF R +YE+F +Q ++A D
Sbjct: 382 GRVQCR------LLGNVPF-------RLQEYESFSTILVDGRLDREQHDQYNLTIQARDG 428
Query: 831 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 890
M + TV++ D ND P FSK Y+ +V + G + +V A D D GL S
Sbjct: 429 GVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPD-LGLNGS 487
Query: 891 RVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 948
V Y++ V+ + + +SG + + N E T F+ V+A D G P + S+
Sbjct: 488 -VSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSN 546
Query: 949 ATVKILVLHPGEIPRFTQEEYRPPPVSELATK--------GTMVGVISA----AAINQSI 996
ATV++++L ++ T PP ++ A G +V V+ A N +
Sbjct: 547 ATVRVIIL---DVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRV 603
Query: 997 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1038
Y + G + F I+ + G + +++SY L V A
Sbjct: 604 TYDMTEG-DRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVA 644
Score = 136 bits (343), Expect = 2e-31
Identities = 152/561 (27%), Positives = 234/561 (41%), Gaps = 92/561 (16%)
Query: 281 TYQAAIPELRTPEELNPIIVTPPIQAIDQDRN---IQPPSDRPGILYSILVGTPEDYPRF 337
++ AA EL E +P P A D D +Q P L+ + + T D RF
Sbjct: 128 SFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKTRGDGSRF 187
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
AEL + + ++R+ + I A P GL I++ D N+ +P F+
Sbjct: 188 -------AELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE 240
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF---LNDYT-SVFT 453
+Y + E++P T +R+ A D D E T ++ F +ND T +F
Sbjct: 241 STYAVSVPENSPPN---------TPVIRLNASDPD-EGTNGQVVYSFYGYVNDRTRELFQ 290
Query: 454 V-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV--IVNIQVMDANDNTPTFP 510
+ +G+ +T+ +D EE Y + A D S P V + V+D NDN P
Sbjct: 291 IDPHSGL---VTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVIN 347
Query: 511 EISYD---VYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI 567
+S + V V PG + + D D G NG + +L F + + TI
Sbjct: 348 LLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLL--GNVPFRLQEYESFSTI 405
Query: 568 APGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGR-PDG 626
++ GR LDRE D+Y L I A DG P
Sbjct: 406 -----LVDGR---------------------------LDREQHDQYNLTIQARDGGVPML 433
Query: 627 TSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEAN---AFVGQVKATDPDAGINGQVH 682
S + +++TD NDN P F PY V+ +E N A++ V A DPD G+NG V
Sbjct: 434 QSAKSFTVLITDENDNHPHFSKPY----YQVIVQENNTPGAYLLSVSARDPDLGLNGSVS 489
Query: 683 Y--------SLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTL 734
Y + F + ++G IY N E +E V+A DG + S T+
Sbjct: 490 YQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGLPSLQSNATV 549
Query: 735 AIKVLDIDDNSPVFT-----NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRS 787
+ +LD++DN+PV T N T V + N G + ++A+D D G N V+Y +
Sbjct: 550 RVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGENGRVTYDMTE 609
Query: 788 PEVKHFFALHPFTGELSLLRS 808
+ + FF + GE+ R+
Sbjct: 610 GD-RGFFEIDQVNGEVRTTRT 629
Score = 135 bits (341), Expect = 3e-31
Identities = 174/713 (24%), Positives = 291/713 (40%), Gaps = 129/713 (18%)
Query: 45 AIDEESRNGTILVDNMLIKGTAG-GPDPTIELSLK---DNVDYWVLMDPVKQMLFLNSTG 100
+++EE R GT++ + AG DP + + ++ + V ++P +L T
Sbjct: 28 SVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHLVDINPSSGLLV---TK 84
Query: 101 RVLDRD-----PPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
+ +DRD P I S+ V + V +++ ++D NDN+P+F
Sbjct: 85 QKIDRDLLCRQSPKCIISLEVMSSSMEICV-------IKVEIKDLNDNAPSFPAAQIELE 137
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN-- 213
++E GT I + A D D G G Y + T N+ F + + G+
Sbjct: 138 ISEAASPGTRIPL-----DSAYDPDSGSFGVQTYEL-------TPNELFGLEIKTRGDGS 185
Query: 214 ----IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
+V+ K L+ E ++ Y I A D + R T L++ V D +D P+F
Sbjct: 186 RFAELVVEKSLDRETQSHYSFRITALDGG---DPPRLGTVGLSIKVTDSNDNNPVF---- 238
Query: 270 LVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVG 329
TY ++PE P P+I + A D D ++YS
Sbjct: 239 --------SESTYAVSVPENSPPN--TPVI---RLNASDPDEGTNGQ-----VVYSFYGY 280
Query: 330 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDEN 389
+ F + P + +++ ++ + ++L ++A+ + +PA + + +LD N
Sbjct: 281 VNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTN 340
Query: 390 NQSPYFTMPSYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLN 446
+ P + S ++ ESAP G I +L S R L+ ++ + L
Sbjct: 341 DNPPVINLLSVNSELVEVSESAPPGYVI--ALVRVSD-RDSGLNGRVQCRLLGNVPFRLQ 397
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG----VQESEPVIVNIQVMDA 502
+Y S T+ G +DRE+ Y +I A DG +Q ++ + + D
Sbjct: 398 EYESFSTILVDG---------RLDREQHDQYNLTIQARDGGVPMLQSAKS--FTVLITDE 446
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 562
NDN P F + Y V V + PG ++ ++A D D G NG ++Y+I+ D +
Sbjct: 447 NDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPV---F 503
Query: 563 GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD- 621
++I P G YAL ++ + E T + + A D
Sbjct: 504 TYVSINPN----SGDIYAL---------------------RSFNHEQTKAFEFKVLAKDG 538
Query: 622 GRPDGTSTATVNIVVTDVNDNAPVF----------DPYLPRNLSVVEEEANAFVGQVKAT 671
G P S ATV +++ DVNDN PV + Y+PRN + V VKA
Sbjct: 539 GLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGI-----GYLVTVVKAE 593
Query: 672 DPDAGINGQVHYSLGNFN-NLFRITS-NGSIYTAVKLNREVRDYYELVVVATD 722
D D G NG+V Y + + F I NG + T + YEL+VVA D
Sbjct: 594 DYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHD 646
Score = 108 bits (270), Expect = 5e-23
Identities = 124/500 (24%), Positives = 218/500 (43%), Gaps = 59/500 (11%)
Query: 124 KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 183
++GT+ + I V D NDN+P F +Y +V E +P T + A+D D+G
Sbjct: 218 RLGTV---GLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIR-----LNASDPDEGT 269
Query: 184 NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 243
NGQ+ Y +D T + F+I +G + + L+YE+ Y + +QA D N
Sbjct: 270 NGQVVYSFYGYVNDRT-RELFQIDPH-SGLVTVTGALDYEEGHVYELDVQAKDLGPNSIP 327
Query: 244 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 303
+TV VLD +D P+ L+ + + E+ E P V
Sbjct: 328 AHCK---VTVSVLDTNDNPPVI------------NLLSVNSELVEVS--ESAPPGYVIAL 370
Query: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
++ D+D + G + L+G + P + + + + ++R+ H +++L
Sbjct: 371 VRVSDRDSGLN------GRVQCRLLG---NVPFRLQEYESFSTILVDGRLDREQHDQYNL 421
Query: 364 VIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
I+A +D G P L + + I DEN+ P+F+ P YQ + E+ GA +
Sbjct: 422 TIQA-RDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYL-------- 472
Query: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI---TRYLTLLQPVDREEQQTYTF 479
L + A D D+ + + + T I + + L+ + E+ + + F
Sbjct: 473 -LSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEF 531
Query: 480 SITAFDGVQES--EPVIVNIQVMDANDNTP--TFPEI---SYDVYVYTDMRPGDSVIQLT 532
+ A DG S V + ++D NDNTP T P + + +VY+ + G V +
Sbjct: 532 KVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVK 591
Query: 533 AVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
A D DEG NG +TY++ G +G F I++ G + +Y L V A D+ +
Sbjct: 592 AEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTS 651
Query: 593 ERSTG--ILTLGKALDREST 610
++ ++ L ALD + +
Sbjct: 652 LSASALVLIYLSPALDAQES 671
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 190 bits (482), Expect = 1e-47
Identities = 263/1100 (23%), Positives = 427/1100 (38%), Gaps = 154/1100 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN P F+ + Y A V E G + ATD D GPNG + Y ++
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRV-----RATDRDLGPNGFVRYSVR 336
Query: 193 YNP-------DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
+ + L+G + + + L+ E + + ++++A D E
Sbjct: 337 ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA---EPE 393
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE---LRTPEELNPIIVTP 302
T +++ VLD D RP + + E R E P
Sbjct: 394 VATVRVSIAVLD----------------VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437
Query: 303 PIQAIDQDRNIQPPSDRPGILY------SI---LVGTPEDYPRFFHMHPRTAELSLLEPV 353
+ D D + + + G L SI L G D+ P L + P+
Sbjct: 438 RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497
Query: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 413
+R+ ++L++ A PL L + + D N+Q P F+ Y+ + E+A G
Sbjct: 498 DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557
Query: 414 I-----SDS--------------LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
+ SD+ + L++P + +L + T + ++ + +
Sbjct: 558 VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST 617
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEI 512
+T +DRE Q+ + A D + S +V+I V D NDN P F
Sbjct: 618 IRT-----------LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572
Y+ + G +Q+TA DAD G G I Y + G F+ + I P
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDG----FLSYEAPQAFRIDP--- 719
Query: 573 MIVGRTYALTVQAADNAPPAERSTGILTLGKALDRE-STDRYILIITASDGRPDGTST-A 630
G + + + +DRE Y L++ A DG G S A
Sbjct: 720 ----------------------HDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQA 755
Query: 631 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNF 688
V + + DVNDN PVF+P E + + V ATD D+GI G V Y L GN
Sbjct: 756 FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815
Query: 689 NNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV 747
++LF I S G IY + L+ L+V A DG + I +
Sbjct: 816 SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
Query: 748 FTNSTYTVLVEENLPAGTTILQIEAKD-VDLGANVSYRIRSPEVKHFFALHPFTGELSLL 806
F YT LV E++P + I ++A++ ++ + YRI S ++ F++HP G +
Sbjct: 876 FERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTR 935
Query: 807 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVA 865
+ LD+E P + V+A G+ P +T V + V D+ND P F + + ++
Sbjct: 936 KPLDHETQP----VVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRIS 989
Query: 866 PDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 923
GT + AED D GL +RY + Q +F ++ G + +L
Sbjct: 990 QTTPPGTALYLARAEDRDSGRNGL----IRYSIASPQ----PGVFAIDRALGVLFLNGSL 1041
Query: 924 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE---------EYRPPPV 974
L + A D G ++ + +++ P +T E E P
Sbjct: 1042 GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMT 1101
Query: 975 SELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVL 1034
L T+ +G AA+ + YS+ + FGI TG IY+ DYE+ +Y
Sbjct: 1102 QMLQTQAHPLGPQRAAS---PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
Query: 1035 RVQADSLE-VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVL 1093
RV A E L N+ + V + + DEN++ P F V E +
Sbjct: 1159 RVFAWIPEDGFLQNV-------STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIG 1211
Query: 1094 RVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1153
++ A D D+G + Y L + +GK F + TG + + R + + V+
Sbjct: 1212 KITAIDMDSGKNGQLLYFL----LSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLV 1266
Query: 1154 TDDYGKGLSGKADVLVSVVN 1173
TD + V VSV +
Sbjct: 1267 TDRGSPPRNATMAVYVSVTD 1286
Score = 186 bits (472), Expect = 2e-46
Identities = 218/832 (26%), Positives = 342/832 (41%), Gaps = 115/832 (13%)
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
FH+HP T + ++R+ + V L A + I + D N+ SP F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 398 PSYQGYILESAPVGATI--------SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT 449
S Q + E +P G L T +V +D P L
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 450 SVFTVTQTGITR-----YLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDA 502
+ + G + L LL+ +DREE + I A+DG + + + V ++V+D
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTT 562
NDN P F + Y V D +PG V ++ A D D G NG + Y +
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQ---------- 339
Query: 563 GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG 622
PG G AA A E +G++ + + LDRE+ + L++ A DG
Sbjct: 340 -----VPG----AGSGGGALGDAAYFA--VEELSGVVRVWRPLDREAQAWHQLVVEARDG 388
Query: 623 RPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA----FVGQVKATDPDA-- 675
+ +T V+I V DVNDN P V A +V +V +D D
Sbjct: 389 GAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDW 448
Query: 676 ----------GI---NGQVHYSLGNFNNLFRITSNGS---IYTAVK--LNREVRDYYELV 717
G+ +G + SL F + G + V+ L+RE RD YEL+
Sbjct: 449 EKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELL 508
Query: 718 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD- 776
+VATD P + TL ++V D++D P+F+ Y V E GT ++ + A D D
Sbjct: 509 LVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADE 568
Query: 777 --------------------LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 816
LG+ S + + E FA+ +G +S +R+LD E
Sbjct: 569 AGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREV--- 625
Query: 817 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 874
QEA + V A D+ PP AT V++ V D+ND P+F +++Y +A A G
Sbjct: 626 QEA-VELKVVAQDL--GEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCF 682
Query: 875 TTVYAEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEE--PTTIF 931
V A DAD GL + Y + D Y A F ++ G++ +++ E P T +
Sbjct: 683 LQVTASDAD-SGL-YGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPAT-Y 739
Query: 932 KLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA- 989
L+V A D G +S+ A V++ + + P F Y E ++ V++
Sbjct: 740 DLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATD 797
Query: 990 --AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLAN 1047
+ I ++ Y ++ GN F I++ TG+IY+ PL + T+ L V A + A
Sbjct: 798 QDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAV 857
Query: 1048 LRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATD 1099
+ A V I I P F++ Y V ED + + VKA +
Sbjct: 858 I-------NADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE 902
Score = 173 bits (438), Expect = 2e-42
Identities = 273/1108 (24%), Positives = 440/1108 (39%), Gaps = 171/1108 (15%)
Query: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA-------- 176
+G ++ E+R V D ND+SP F +S V+EL+P GT + D A
Sbjct: 147 LGAVVQVEIR--VNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGY 204
Query: 177 -----TDIDDGPNGQIEYVIQY-------NPDDPTSNDTFEIPLMLTGNIVLRKRLNYED 224
+D+ P G + ++Y +P P S+ E PL ++VL +RL+ E+
Sbjct: 205 TLVQPSDLPKDPAGPF-FQLRYRTPGPLPSPLLPGSSSPLE-PL----DLVLLRRLDREE 258
Query: 225 KTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQA 284
+ + I+A D + RRT ++ + VLD +D P+F Y+A
Sbjct: 259 AAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVF------------EQDEYRA 303
Query: 285 AIPELRTPEELNPIIVTPPIQAIDQD-----------RNIQPPSDRPGILYSILVGTPED 333
A+ E+ P ++A D+D R Q P G G
Sbjct: 304 AV-----REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG-------GGALG 351
Query: 334 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 393
+F + + + + P++R+ LV++A P A + I +LD N+ P
Sbjct: 352 DAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
Query: 394 ----YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE--------- 440
F + E A G ++ R+ D D + K+ E
Sbjct: 412 AIHVLFLTEGGVARVSEGARPGDYVA---------RVSVSDADGDWEKEDEATGELGVGL 462
Query: 441 ----LHLFLNDYTSVFTVTQTGI--TRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEP 492
+ L L F + G +L + P+DRE + Y + A D S
Sbjct: 463 GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
+ ++V D ND P F + Y V PG V+ ++A DADE A
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADE-------------A 569
Query: 553 QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP--PAERSTGILTLGKALDREST 610
D + T + AP +G + V A+ P + +G ++ + LDRE
Sbjct: 570 GSDHAWLRYTVVQLSAP---CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQ 626
Query: 611 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE--ANAFVGQ 667
+ L + A D G P ++T V+I V DVNDN P+F + N ++ E + F+ Q
Sbjct: 627 EAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQV-YNATIAEHAPVGHCFL-Q 684
Query: 668 VKATDPDAGINGQVHYSLGN------FNNLFRI-TSNGSIYTAVKLNREVRD--YYELVV 718
V A+D D+G+ G + YSL + FRI +G I + ++RE RD Y+L+V
Sbjct: 685 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRE-RDPATYDLLV 743
Query: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 778
A DG + + + ++ D++DN PVF STY + + GT I+ + A D D G
Sbjct: 744 EAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSG 801
Query: 779 --ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
V+Y + V F + TG + L L + + +++ +V A D G
Sbjct: 802 IYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHL----ESTTLSLMVSAQDGGGLTAV 857
Query: 837 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 896
A VT+ + P F + Y +V D + +PI TV A + P + + YR+
Sbjct: 858 INADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKARE---PLNSSEPIFYRI 914
Query: 897 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 956
F + G + TR L+ E + L V A P SS+ V I V+
Sbjct: 915 SSGDL---GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSST-EVNITVM 970
Query: 957 -----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007
HP + T +E R +S+ GT + + A + N I YSI S +
Sbjct: 971 DVNDNHPAFLR--TSDEIR---ISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS-PQPG 1024
Query: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
F I+ GV+++NG L + L ++A+ V V + ++
Sbjct: 1025 VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV--------HPQAALLVLTVVIEKR 1076
Query: 1068 NHPP--VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFV 1125
H P F+ Y VSE T +L+ +A + + P + F
Sbjct: 1077 EHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAM--FG 1134
Query: 1126 VETYTGLIKTAMLFHNMRRSYFKFQVIA 1153
+ YTG I F + F+V A
Sbjct: 1135 IRPYTGWIYLRRQFDYESTQTYNFRVFA 1162
Score = 151 bits (382), Expect = 5e-36
Identities = 250/1059 (23%), Positives = 420/1059 (39%), Gaps = 141/1059 (13%)
Query: 101 RVLDRDPPMNIHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPT----FKHESYYA 154
R LDR+ H +VV+ + +V T+ V I V D NDN P F E A
Sbjct: 369 RPLDREAQA-WHQLVVEARDGGAEPEVATV---RVSIAVLDVNDNRPAIHVLFLTEGGVA 424
Query: 155 TVNELTPVGTTIF-TGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 213
V+E G + S +G + +D G++ + + +L G
Sbjct: 425 RVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGG 484
Query: 214 ------IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLP 267
+ + L+ E + Y +++ A D + +T TL + V D +D P+F
Sbjct: 485 PPGVFFLCVEGPLDRESRDLYELLLVATDAG---SPPLSTEETLLLRVADLNDQPPLF-- 539
Query: 268 CVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR--------NIQPPSDR 319
Y+A++ E P + + D + P +
Sbjct: 540 ----------SQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNL 589
Query: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFA 379
G L S +V T E P F + + +S + ++R+ + +L + A+ PL A
Sbjct: 590 -GSLQSKMVHTAECGPSFA-IDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATC 647
Query: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
+ I + D N+ P F Y I E APVG L++ A D D
Sbjct: 648 LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCF---------LQVTASDADSGLYGFI 698
Query: 440 ELHLFLNDYTSVFTVTQTGITRY---LTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIV 495
E L+ + + S I + + + Q +DRE + TY + A DG S V
Sbjct: 699 EYSLY-DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFV 757
Query: 496 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 555
+ + D NDN P F +Y + + +PG +I + A D D G G + YE++ G
Sbjct: 758 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
Query: 556 -FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYI 614
F I+ TTG+I + + + T +L V A D T ++ + T
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGG----LTAVINADVTIHIFQTT--- 870
Query: 615 LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 674
+ A RP T +V DV +++P+ G VKA +P
Sbjct: 871 -LAPAEFERPKYTF-----LVYEDVPEDSPI--------------------GTVKAREP- 903
Query: 675 AGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 731
+ + Y S G+ F I G+I T L+ E + L V A G+ P S+
Sbjct: 904 LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA-PACSS 962
Query: 732 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 789
+ I V+D++DN P F ++ + + + P GT + A+D D G N + Y I SP+
Sbjct: 963 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ 1022
Query: 790 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 849
FA+ G L L SL ++ +T + A D G P V +V +
Sbjct: 1023 -PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTVVIEKR 1076
Query: 850 DYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPA 905
++ P F +Y+ V+ +P+T + A P P AS +RY ++ +
Sbjct: 1077 EHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP---SVDS 1130
Query: 906 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHPGE-IP 962
++F + +G + R + E T + V A+ +DG + + S TV + V + P
Sbjct: 1131 AMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSP 1189
Query: 963 RFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITG 1016
F + E P P + G + + + N ++Y ++S + F +N TG
Sbjct: 1190 TFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKMNPNTG 1244
Query: 1017 VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-- 1074
+ LD E R + + V++ + P ++ T VY+ + D N++ P F
Sbjct: 1245 ELINWVALDREHRGHH-------EMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQC 1297
Query: 1075 ---KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1110
K+ ++ V E + V V A D D GN + + Y
Sbjct: 1298 LPGKELHV-KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
Score = 124 bits (312), Expect = 7e-28
Identities = 194/801 (24%), Positives = 307/801 (38%), Gaps = 105/801 (13%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST R LDR+ + VV + V I V D NDN P F + Y AT+
Sbjct: 616 STIRTLDREVQEAVELKVVAQDLGEPPLSATCL--VSITVDDVNDNEPIFWRQVYNATIA 673
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E PVG A+D D G G IEY + + F I G I +
Sbjct: 674 EHAPVGHCFL-----QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH-DGQICVS 727
Query: 218 KRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
+ ++ E D Y ++++A D + + VD+ D +D P+F P V + D
Sbjct: 728 QDIDRERDPATYDLLVEAKDGGG-----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
Query: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
E P + A DQD I + Y ++ P +
Sbjct: 783 -----------------ETQPGTEIINVLATDQDSGIYGT-----VAYELI---PGNVSS 817
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
F + T + L P++ L++ A+ G A + I I F
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-T 455
P Y + E P SP+ V + + ++ + D F++
Sbjct: 878 RPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
Query: 456 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTFPEISY 514
+ G R +P+D E Q ++ A G + VNI VMD NDN P F S
Sbjct: 928 RLGTIR---TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSD 984
Query: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 574
++ + PG ++ A D D G NG I Y I G F I++ G++ + +
Sbjct: 985 EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAG 1044
Query: 575 VGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 634
R LT++A D + + +LT ++I + P T V
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLT--------------VVIEKREHSPSWTFEHLVYQ 1090
Query: 635 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLF 692
V +V+++ L +++ +A+ +G +A P + YSL + +F
Sbjct: 1091 V--EVSES-------LSPMTQMLQTQAHP-LGPQRAASP-------LRYSLEPSVDSAMF 1133
Query: 693 RITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHPRHSTLTLAIKVLDIDDNSPVF 748
I G IY + + E Y V A DG + ++ + T+ ++V D +DNSP F
Sbjct: 1134 GIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL--QNVSTTVIVRVWDENDNSPTF 1191
Query: 749 TNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRS 808
+ + VEE+ I +I A D+D G N FF ++P TGEL +
Sbjct: 1192 LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVA 1251
Query: 809 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAP 866
LD E E ++ PP AT+ V V D+ND P F + + +
Sbjct: 1252 LDREHRGHHEMTVLVTDRG------SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV 1305
Query: 867 DAVKGTP----ITTVYAEDAD 883
++G P +TTV+A+D D
Sbjct: 1306 KVLEGQPVNMLVTTVFAKDPD 1326
Score = 117 bits (292), Expect = 1e-25
Identities = 168/675 (24%), Positives = 276/675 (40%), Gaps = 112/675 (16%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y +
Sbjct: 757 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY--E 809
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
P + +S T + TG I L L++ + T +++ A D T +
Sbjct: 810 LIPGNVSSLFTID---STTGIIYLTLPLSHLESTTLSLMVSAQDGGG-------LTAVIN 859
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
DV L P + RP Y + E PE+ PI + +
Sbjct: 860 ADVTIH------IFQTTLAPAEFE-RP-KYTFLVYE-DVPED-------SPIGTV---KA 900
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 901 REPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA 957
Query: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 958 -PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAED 1005
Query: 433 IEDTKDPELHLFL-NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQES 490
+ ++ + + + VF + + L L + EQ+ T ++ A D GV
Sbjct: 1006 RDSGRNGLIRYSIASPQPGVFAIDRA--LGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQ 1063
Query: 491 EPVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYE 547
++V V++ +++P TF + Y V V + P ++Q A + + + Y
Sbjct: 1064 AALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRY- 1122
Query: 548 ILVGAQGDFIINKTTGLITIAPGVE--MIVGRTYALTVQAADNAPPAERSTGILTLGKAL 605
++ P V+ M R Y TG + L +
Sbjct: 1123 ------------------SLEPSVDSAMFGIRPY----------------TGWIYLRRQF 1148
Query: 606 DRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA- 661
D EST Y + A DG ST TV + V D NDN+P F L L + EE+
Sbjct: 1149 DYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESP 1204
Query: 662 --NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 718
+G++ A D D+G NGQ+ Y L + F++ N G + V L+RE R ++E+ V
Sbjct: 1205 VPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTV 1264
Query: 719 VATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKD 774
+ TD PR++T+ + + V DI+DN P F V V E P + + AKD
Sbjct: 1265 LVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 1324
Query: 775 VDLG--ANVSYRIRS 787
D G A V+Y + S
Sbjct: 1325 PDEGNNAEVTYSVSS 1339
Score = 108 bits (270), Expect = 5e-23
Identities = 147/559 (26%), Positives = 220/559 (39%), Gaps = 95/559 (16%)
Query: 698 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 757
G I TA +L+RE RD+Y V GAV + + I+V D++D+SP F + + V
Sbjct: 123 GIIRTARRLDRERRDHYSFVAATLLGAV------VQVEIRVNDVNDHSPRFPLDSLQLDV 176
Query: 758 EENLPAGTTILQIEAKDVDLG--ANVSYRIRSPE------VKHFFALHPFTG-------- 801
E P GT A D D G + Y + P FF L T
Sbjct: 177 SELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLL 236
Query: 802 ----------ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY 851
+L LLR LD E + A+ +EA+D G+ +V + V D ND
Sbjct: 237 PGSSSPLEPLDLVLLRRLDRE----EAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDN 292
Query: 852 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFP--------- 902
PPVF + Y+ V DA G + V A D D P VRY V Q P
Sbjct: 293 PPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLG--PNGFVRYSVRARQVPGAGSGGGAL 350
Query: 903 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG-EP-------------VMSSS 948
A+ F VEE SG V L+ E +LVV A D G EP V +
Sbjct: 351 GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
Query: 949 ATVKILVLHPGEIPRFTQEEYRPPPVSELAT---------KGTMVGVISAAAINQSIVYS 999
+ +L L G + R ++ V+ ++ + G + + SI S
Sbjct: 411 PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
Query: 1000 IVSGNEEDTFGINNITGVIY--VNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1057
+ G + GV + V GPLD E+R Y L +V + P S
Sbjct: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLY-------ELLLVATDAGSPPLSTEE 523
Query: 1058 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT--GNYSVMAYRLI-- 1113
+ + + D N+ PP+F ++ Y VSE A T V+ V A+D D +++ + Y ++
Sbjct: 524 TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
Query: 1114 ------------IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1161
+ E F +++ +G I T + + +V+A D L
Sbjct: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPL 643
Query: 1162 SGKADVLVSVVNQLDMQVI 1180
S V ++V + D + I
Sbjct: 644 SATCLVSITVDDVNDNEPI 662
Score = 53.1 bits (126), Expect = 2e-06
Identities = 96/403 (23%), Positives = 164/403 (40%), Gaps = 85/403 (21%)
Query: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 984 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 1025
Query: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 1026 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 1078
Query: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 1079 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 1129
Query: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 1130 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 1182
Query: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
D +D P FL VL L+ E P V I AID D
Sbjct: 1183 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMD------ 1219
Query: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
S + G L L+ +FF M+P T EL ++R+ ++ + P
Sbjct: 1220 SGKNGQLLYFLLSDG----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRN 1275
Query: 377 AFAGLHIEILDENNQSPYF--TMPSYQGY--ILESAPVGATIS 415
A +++ + D N+ P+F +P + + +LE PV ++
Sbjct: 1276 ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVT 1318
Score = 34.3 bits (77), Expect = 1.2
Identities = 33/109 (30%), Positives = 44/109 (40%), Gaps = 13/109 (11%)
Query: 1007 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1066
D F ++ TG+I LD E R Y V A L V+ +V I + D
Sbjct: 114 DDFHVHPDTGIIRTARRLDRERRDHYSF-VAATLLGAVV------------QVEIRVNDV 160
Query: 1067 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1115
N+H P F VSE + T+ A D D G +S Y L+ P
Sbjct: 161 NDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQP 209
Score = 33.1 bits (74), Expect = 2.6
Identities = 26/70 (37%), Positives = 29/70 (41%), Gaps = 2/70 (2%)
Query: 1684 ISPPSPPPAP--APLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSVSTSGPPTPPL 1741
+S SPP P+A PD FS PS P FF L T GP PL
Sbjct: 176 VSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPL 235
Query: 1742 LPPFPTPLPP 1751
LP +PL P
Sbjct: 236 LPGSSSPLEP 245
>gi|14270499 protocadherin gamma subfamily B, 4 isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 189 bits (480), Expect = 2e-47
Identities = 185/653 (28%), Positives = 293/653 (44%), Gaps = 91/653 (13%)
Query: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
F +++EI D N+ +P FT S++ I ESA G T + A D DI
Sbjct: 116 FYHVNVEIEDINDHTPKFTQNSFELQISESAQPG---------TRFILGSAHDADIGSNT 166
Query: 438 DPELHLFLNDYTSVFTVTQTGITRY--LTLLQPVDREEQQTYTFSITAFD--GVQESEPV 493
L +D+ S+ ++ ++Y + L P+DRE+Q++Y ++TA D S
Sbjct: 167 LQNYQLSPSDHFSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTA 226
Query: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
+++ V DANDN P F + Y V + ++ PG +V+Q+TA D DEG N EIT+ +Q
Sbjct: 227 QIHVLVTDANDNAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQ 286
Query: 554 -GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDR 612
F +N TG IT+ LD E
Sbjct: 287 ITQFDLNSNTGEITVL----------------------------------NTLDFEEVKE 312
Query: 613 YILIITASDGRPDGTSTATVNIVVTDVNDNAP-VFDPYLPRNLSVVEEEANAFVGQVKAT 671
Y +++ A DG + TV + V D NDNAP V LP NL + + E + +K
Sbjct: 313 YSIVLEARDG-GGMIAQCTVEVEVIDENDNAPEVIFQSLP-NLIMEDAELGTHIALLKVR 370
Query: 672 DPDAGINGQVHYSLGNFNNLFRITSNGSIY---TAVKLNREVRDYYELVVVATDGAVHPR 728
D D+ NG+V L +TS+ + Y T L+RE Y + V ATD P
Sbjct: 371 DKDSRHNGEVTCKLEGDVPFKILTSSRNTYKLVTDAVLDREQNPEYNITVTATDRGKPPL 430
Query: 729 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 786
S+ ++ + + D++DN+PVF+ S+Y V V EN P G +I Q+ A D DLG N VSY I
Sbjct: 431 SSSSSITLHIGDVNDNAPVFSQSSYIVHVAENNPPGASISQVRASDPDLGPNGQVSYCIM 490
Query: 787 SP-----EVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATV 841
+ E+ + ++ +G + R+ D+E Q + ++A D ++
Sbjct: 491 ASDLEQRELSSYVSISAESGVVFAQRAFDHE----QLRAFELTLQARDQGSPALSANVSL 546
Query: 842 TVIVKDMNDYPPVFSKRIYKGMVAPD-----------AVKGTPITTVYAEDADPPGLPAS 890
V+V D ND P R+ + PD A G +T V A DAD +
Sbjct: 547 RVLVDDRNDNAP----RVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSG--HNA 600
Query: 891 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 950
+ Y V P +F + +G V T L + +L+V D G+P +S++AT
Sbjct: 601 WLSYHVLQASEP---GLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATAT 657
Query: 951 VKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1001
+ ++ + +P T RP P S+L + V++ A I+ + +++
Sbjct: 658 LHLVFADSLQEVLPDITD---RPDP-SDLQAELQFYLVVALALISVLFLVAMI 706
Score = 134 bits (338), Expect = 6e-31
Identities = 146/544 (26%), Positives = 236/544 (43%), Gaps = 74/544 (13%)
Query: 632 VNIVVTDVNDNAPVFDPY-LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG---N 687
VN+ + D+ND+ P F +S + F+ A D D G N +Y L +
Sbjct: 119 VNVEIEDINDHTPKFTQNSFELQISESAQPGTRFI-LGSAHDADIGSNTLQNYQLSPSDH 177
Query: 688 FNNLFRITSNGSIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 743
F+ + + S+GS Y + L+RE + Y L + A D P ST + + V D +D
Sbjct: 178 FSLINKEKSDGSKYPEMVLKTPLDREKQKSYHLTLTALDFGAPPLSSTAQIHVLVTDAND 237
Query: 744 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHF--FALHPFTG 801
N+PVF+ Y V + EN+ GTT+LQ+ A D D G N E F L+ TG
Sbjct: 238 NAPVFSQDVYRVSLSENVYPGTTVLQVTATDQDEGVNAEITFSFSEASQITQFDLNSNTG 297
Query: 802 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 861
E+++L +LD+E + + ++EA D G + TV V V D ND P +
Sbjct: 298 EITVLNTLDFE----EVKEYSIVLEARDGGGMIAQ--CTVEVEVIDENDNAPEVIFQSLP 351
Query: 862 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD-DVQFPYPASIFEVEEDSGRVITR 920
++ DA GT I + D D SR V ++ P I ++ +++T
Sbjct: 352 NLIMEDAELGTHIALLKVRDKD------SRHNGEVTCKLEGDVPFKILTSSRNTYKLVTD 405
Query: 921 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEY------- 969
L+ E + + V A D G+P +SSS+++ LH G++ P F+Q Y
Sbjct: 406 AVLDREQNPEYNITVTATDRGKPPLSSSSSI---TLHIGDVNDNAPVFSQSSYIVHVAEN 462
Query: 970 RPPPVS---------ELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYV 1020
PP S +L G + I A+ + Q + S VS + E +GV++
Sbjct: 463 NPPGASISQVRASDPDLGPNGQVSYCIMASDLEQRELSSYVSISAE--------SGVVFA 514
Query: 1021 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN-NHPPVFQKKFYI 1079
D+E ++ L +QA + P+ S + + + D N N P V
Sbjct: 515 QRAFDHEQLRAFELTLQA-------RDQGSPALSANVSLRVLVDDRNDNAPRVLYPALGP 567
Query: 1080 GG------VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGL 1132
G V A V +V A D D+G+ + ++Y + ++ + G F + TG
Sbjct: 568 DGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHV----LQASEPGLFSLGLRTGE 623
Query: 1133 IKTA 1136
++TA
Sbjct: 624 VRTA 627
Score = 124 bits (312), Expect = 7e-28
Identities = 163/716 (22%), Positives = 287/716 (40%), Gaps = 109/716 (15%)
Query: 46 IDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGR--VL 103
I EE G+++ + G + PT +L + Y+ + ++L + R +
Sbjct: 37 IPEEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDREEIC 96
Query: 104 DRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
+ P + V +N ++ V + + D ND++P F S+ ++E G
Sbjct: 97 GKKPACALEFEAVAENPLN-------FYHVNVEIEDINDHTPKFTQNSFELQISESAQPG 149
Query: 164 TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS------NDTFEIPLMLTGNIVLR 217
T G A D D G N Y Q +P D S +D + P M VL+
Sbjct: 150 TRFILG-----SAHDADIGSNTLQNY--QLSPSDHFSLINKEKSDGSKYPEM-----VLK 197
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+ E + Y + + A D ++T + V V D +D P+F V
Sbjct: 198 TPLDREKQKSYHLTLTALDFGA---PPLSSTAQIHVLVTDANDNAPVFSQDV-------- 246
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Y+ ++ E + P + A DQD + I +S +
Sbjct: 247 ----YRVSL-----SENVYPGTTVLQVTATDQDEGVNAE-----ITFSF---SEASQITQ 289
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F ++ T E+++L ++ + +++ +V++A G + A + +E++DEN+ +P
Sbjct: 290 FDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGG--MIAQCTVEVEVIDENDNAPEVIF 347
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
S I+E A +G I+ + +D + + E+ L +T +
Sbjct: 348 QSLPNLIMEDAELGTHIA-----------LLKVRDKDSRHNGEVTCKLEGDVPFKILTSS 396
Query: 458 GITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEISYD 515
T L +DRE+ Y ++TA D + S + + + D NDN P F + SY
Sbjct: 397 RNTYKLVTDAVLDREQNPEYNITVTATDRGKPPLSSSSSITLHIGDVNDNAPVFSQSSYI 456
Query: 516 VYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIV 575
V+V + PG S+ Q+ A D D G NG+++Y I+ D + + ++I+
Sbjct: 457 VHVAENNPPGASISQVRASDPDLGPNGQVSYCIMA---SDLEQRELSSYVSIS------- 506
Query: 576 GRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 634
+G++ +A D E + L + A D G P ++ ++ +
Sbjct: 507 ------------------AESGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRV 548
Query: 635 VVTDVNDNAP-VFDPYLPRNLSVVEE------EANAFVGQVKATDPDAGINGQVHYSL-- 685
+V D NDNAP V P L + S + + E V +V A D D+G N + Y +
Sbjct: 549 LVDDRNDNAPRVLYPALGPDGSALFDMVPHAAEPGYLVTKVVAVDADSGHNAWLSYHVLQ 608
Query: 686 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 740
+ LF + G + TA L L+V DG P +T TL + D
Sbjct: 609 ASEPGLFSLGLRTGEVRTARALGDRDAVRQRLLVAVRDGGQPPLSATATLHLVFAD 664
Score = 94.7 bits (234), Expect = 7e-19
Identities = 103/432 (23%), Positives = 182/432 (42%), Gaps = 45/432 (10%)
Query: 757 VEENLPAGTTILQIEAKDVDLGANV----SYRIRSPEVKHFFALHPFTGELSLLRSLDYE 812
+ E +P G+ + + DLG +V + ++R K +F + +GEL + LD E
Sbjct: 37 IPEEMPKGSVVGNLAT---DLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSSRLDRE 93
Query: 813 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 872
++ + F+ P V V ++D+ND+ P F++ ++ ++ A GT
Sbjct: 94 EICGKKPACAL---EFEAVAENPLNFYHVNVEIEDINDHTPKFTQNSFELQISESAQPGT 150
Query: 873 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG----RVITRVNLNEEPT 928
A DAD + D S+ E+ G ++ + L+ E
Sbjct: 151 RFILGSAHDADIGSNTLQNYQLSPSD-----HFSLINKEKSDGSKYPEMVLKTPLDREKQ 205
Query: 929 TIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVI 987
+ L + A D G P +SS+A + +LV + P F+Q+ YR +SE GT V +
Sbjct: 206 KSYHLTLTALDFGAPPLSSTAQIHVLVTDANDNAPVFSQDVYR-VSLSENVYPGTTVLQV 264
Query: 988 SAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1043
+A +N I +S ++ F +N+ TG I V LD+E Y + ++A
Sbjct: 265 TATDQDEGVNAEITFSFSEASQITQFDLNSNTGEITVLNTLDFEEVKEYSIVLEARDGGG 324
Query: 1044 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1103
++A V +E+ DEN++ P + + EDA + T + +K DKD+
Sbjct: 325 MIAQ---------CTVEVEVIDENDNAPEVIFQSLPNLIMEDAELGTHIALLKVRDKDSR 375
Query: 1104 NYSVMAYRLIIPPIKEGKEGFVVETYT----GLIKTAMLFHNMRRSYFKFQVIATDDYGK 1159
+ + +L EG F + T + L+ A+L Y V ATD
Sbjct: 376 HNGEVTCKL------EGDVPFKILTSSRNTYKLVTDAVLDREQNPEY-NITVTATDRGKP 428
Query: 1160 GLSGKADVLVSV 1171
LS + + + +
Sbjct: 429 PLSSSSSITLHI 440
Score = 37.0 bits (84), Expect = 0.18
Identities = 38/150 (25%), Positives = 68/150 (45%), Gaps = 12/150 (8%)
Query: 966 QEEYRPPPVSELATKGTMVGVISAA---AINQSIVYSIVSGNEEDTFGINNITGVIYVNG 1022
Q YR P E KG++VG ++ ++ + + +E+ F ++ +G + V+
Sbjct: 32 QIRYRIP---EEMPKGSVVGNLATDLGFSVQELPTRKLRVSSEKPYFTVSAESGELLVSS 88
Query: 1023 PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1082
LD E + A +LE + N V +EI+D N+H P F + + +
Sbjct: 89 RLDREEICG---KKPACALEFEAV---AENPLNFYHVNVEIEDINDHTPKFTQNSFELQI 142
Query: 1083 SEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112
SE A+ T + A D D G+ ++ Y+L
Sbjct: 143 SESAQPGTRFILGSAHDADIGSNTLQNYQL 172
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,051,376
Number of Sequences: 37866
Number of extensions: 4792809
Number of successful extensions: 120101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1030
Number of HSP's successfully gapped in prelim test: 1194
Number of HSP's that attempted gapping in prelim test: 33816
Number of HSP's gapped (non-prelim): 38447
length of query: 1886
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1769
effective length of database: 13,817,196
effective search space: 24442619724
effective search space used: 24442619724
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.