Search of human proteins with 218156340

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
         (749 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                    1500   0.0  
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                    1357   0.0  
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                     1357   0.0  
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]         1084   0.0  
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...  1072   0.0  
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]         1070   0.0  
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...   978   0.0  
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...   978   0.0  
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...   693   0.0  
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]                     676   0.0  
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]          207   4e-53
gi|95089461 discs large homolog 5 [Homo sapiens]                      189   8e-48
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]          184   3e-46
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]           183   6e-46
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]           172   8e-43
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]          164   2e-40
gi|186972120 calcium/calmodulin-dependent serine protein kinase ...   157   3e-38
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]            153   6e-37
gi|186700627 calcium/calmodulin-dependent serine protein kinase ...   152   1e-36
gi|45827729 scribble isoform b [Homo sapiens]                         152   1e-36
gi|45827731 scribble isoform a [Homo sapiens]                         152   1e-36
gi|186700629 calcium/calmodulin-dependent serine protein kinase ...   150   5e-36
gi|10092691 tight junction protein 3 [Homo sapiens]                   149   7e-36
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ...   135   2e-31
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ...   135   2e-31
gi|116875765 tight junction protein 1 isoform b [Homo sapiens]        133   7e-31
gi|116875767 tight junction protein 1 isoform a [Homo sapiens]        133   7e-31
gi|112382257 InaD-like [Homo sapiens]                                 132   2e-30
gi|148746189 multiple PDZ domain protein [Homo sapiens]               122   1e-27
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]          122   2e-27

>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 1500 bits (3884), Expect = 0.0
 Identities = 749/749 (100%), Positives = 749/749 (100%)

Query: 1   MQRPSVSRAENYQLLWDTIASLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFS 60
           MQRPSVSRAENYQLLWDTIASLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFS
Sbjct: 1   MQRPSVSRAENYQLLWDTIASLKQCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFS 60

Query: 61  IAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK 120
           IAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK
Sbjct: 61  IAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK 120

Query: 121 EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180
           EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG
Sbjct: 121 EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180

Query: 181 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPP 240
           AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPP
Sbjct: 181 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPP 240

Query: 241 DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300
           DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR
Sbjct: 241 DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300

Query: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQR 360
           QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQR
Sbjct: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQR 360

Query: 361 GDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHS 420
           GDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHS
Sbjct: 361 GDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHS 420

Query: 421 MSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARR 480
           MSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARR
Sbjct: 421 MSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARR 480

Query: 481 VMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRG 540
           VMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRG
Sbjct: 481 VMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRG 540

Query: 541 QEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEV 600
           QEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEV
Sbjct: 541 QEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEV 600

Query: 601 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 660
           DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI
Sbjct: 601 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 660

Query: 661 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 720
           KRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD
Sbjct: 661 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 720

Query: 721 TLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
           TLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Sbjct: 721 TLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 1357 bits (3513), Expect = 0.0
 Identities = 699/784 (89%), Positives = 701/784 (89%), Gaps = 70/784 (8%)

Query: 36  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
           VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV
Sbjct: 192 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 251

Query: 96  NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
           NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS
Sbjct: 252 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 311

Query: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
           IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK
Sbjct: 312 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 371

Query: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
           NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR
Sbjct: 372 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 431

Query: 276 YSPIPKHMLVDDDYT--------------------------------------------- 290
           YSPIPKHMLVDDDYT                                             
Sbjct: 432 YSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGL 491

Query: 291 -------SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 343
                  SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV
Sbjct: 492 LPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 551

Query: 344 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 403
           SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA
Sbjct: 552 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 611

Query: 404 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
           RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD
Sbjct: 612 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 671

Query: 464 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 523
           ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG
Sbjct: 672 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 731

Query: 524 DIPGLGDDGY------------------GTKTLRGQEDLILSYEPVTRQEINYTRPVIIL 565
                    +                   +   RGQEDLILSYEPVTRQEINYTRPVIIL
Sbjct: 732 SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIIL 791

Query: 566 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 625
           GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE
Sbjct: 792 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 851

Query: 626 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 685
           AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME
Sbjct: 852 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 911

Query: 686 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
           MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS
Sbjct: 912 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 971

Query: 746 KEKL 749
           KEKL
Sbjct: 972 KEKL 975


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 1357 bits (3513), Expect = 0.0
 Identities = 699/784 (89%), Positives = 701/784 (89%), Gaps = 70/784 (8%)

Query: 36  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
           VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV
Sbjct: 87  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 146

Query: 96  NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
           NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS
Sbjct: 147 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 206

Query: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
           IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK
Sbjct: 207 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 266

Query: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
           NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR
Sbjct: 267 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 326

Query: 276 YSPIPKHMLVDDDYT--------------------------------------------- 290
           YSPIPKHMLVDDDYT                                             
Sbjct: 327 YSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGL 386

Query: 291 -------SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 343
                  SHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV
Sbjct: 387 LPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 446

Query: 344 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 403
           SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA
Sbjct: 447 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 506

Query: 404 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
           RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD
Sbjct: 507 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 566

Query: 464 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 523
           ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG
Sbjct: 567 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 626

Query: 524 DIPGLGDDGY------------------GTKTLRGQEDLILSYEPVTRQEINYTRPVIIL 565
                    +                   +   RGQEDLILSYEPVTRQEINYTRPVIIL
Sbjct: 627 SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIIL 686

Query: 566 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 625
           GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE
Sbjct: 687 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 746

Query: 626 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 685
           AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME
Sbjct: 747 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 806

Query: 686 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
           MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS
Sbjct: 807 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 866

Query: 746 KEKL 749
           KEKL
Sbjct: 867 KEKL 870


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 1084 bits (2804), Expect = 0.0
 Identities = 545/724 (75%), Positives = 619/724 (85%), Gaps = 42/724 (5%)

Query: 36  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
           VNGT+ +YE+EEITLERGNSGLGFSIAGGTDNPHIGDD  IFITKII GGAAA+DGRLRV
Sbjct: 213 VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRV 272

Query: 96  NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
           NDCILRVNEVDV +V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFS
Sbjct: 273 NDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFS 332

Query: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
           IAGGVGNQHIPGDNSIYVTKII+GGAA KDG+LQ+GD+LL VNN  LEEVTHEEAV  LK
Sbjct: 333 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALK 392

Query: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
           NTS+ VYLKV KPT++YM D Y PPDIT+S S P++NH+   +           P SP R
Sbjct: 393 NTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF------LGQTPASPAR 446

Query: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG 335
           YSP+ K +L DD+ T                        EPRKVVLH+GSTGLGFNIVGG
Sbjct: 447 YSPVSKAVLGDDEITR-----------------------EPRKVVLHRGSTGLGFNIVGG 483

Query: 336 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIA 395
           EDGEGIF+SFILAGGPADLSGEL++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+A
Sbjct: 484 EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVA 543

Query: 396 QYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ 455
           QY+PE+Y+RFEAKIHDLREQMMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQ
Sbjct: 544 QYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ 603

Query: 456 GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAK 515
           GL+FK+GDILHVINASDDEWWQAR+V  +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K
Sbjct: 604 GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663

Query: 516 PGVIDSKGDIPG-LGDDGY---------GTKTLRGQEDLILSYEPVTRQEINYTRPVIIL 565
                 KG+IP  +G  G             + RGQE+ +LSYEPV +QE+NYTRPVIIL
Sbjct: 664 TR---DKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL 720

Query: 566 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 625
           GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIE
Sbjct: 721 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE 780

Query: 626 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 685
           AGQYN++LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +ME
Sbjct: 781 AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME 840

Query: 686 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
           MNKRLTEEQA+KT++RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+
Sbjct: 841 MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA 900

Query: 746 KEKL 749
           KEKL
Sbjct: 901 KEKL 904


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 1072 bits (2773), Expect = 0.0
 Identities = 530/733 (72%), Positives = 622/733 (84%), Gaps = 30/733 (4%)

Query: 24  QCEQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 83
           +C    +  +  VNG++  +++EEI LERGNSGLGFSIAGG DNPH+ DDPGIFITKIIP
Sbjct: 108 ECTCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIP 167

Query: 84  GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 143
           GGAAA DGRL VNDC+LRVNEVDVSEV HS+AVEALKEAG +VRL VRRR+P  ET++E+
Sbjct: 168 GGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEV 227

Query: 144 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203
            L KGPKGLGFSIAGG+GNQHIPGDNSIY+TKII+GGAAQKDGRLQ+GDRLL VNN +L+
Sbjct: 228 NLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQ 287

Query: 204 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN---- 259
           +V HEEAVA LKNTS++VYLKV KP ++++ D Y PPD   +++   +NH+   ++    
Sbjct: 288 DVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYL 347

Query: 260 GTLEYKTSLPP---ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEP 316
           G +E K S P    + P RYSPIP+HML ++D+T                        EP
Sbjct: 348 GAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTR-----------------------EP 384

Query: 317 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376
           RK++LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR A+
Sbjct: 385 RKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444

Query: 377 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 436
           HEQAAAALK AGQ+VTI+AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KRSL
Sbjct: 445 HEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSL 504

Query: 437 YVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSK 496
           YVRA+FDYD+++DS LPSQGLSF YGDILHVINASDDEWWQAR V   G+SE++GVIPSK
Sbjct: 505 YVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSK 564

Query: 497 RRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEI 556
           +RVE+KERARLKTVKF+A+ G+I+S  D PGL DD YG K L+GQED ILSYEPVTRQEI
Sbjct: 565 KRVEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEI 624

Query: 557 NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 616
           +Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEK
Sbjct: 625 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684

Query: 617 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 676
           DIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIK
Sbjct: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744

Query: 677 PRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQ 736
           P+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+Q
Sbjct: 745 PKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQ 804

Query: 737 SGPFIWIPSKEKL 749
           SG +IW+PS EKL
Sbjct: 805 SGHYIWVPSPEKL 817


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 1070 bits (2766), Expect = 0.0
 Identities = 541/745 (72%), Positives = 615/745 (82%), Gaps = 62/745 (8%)

Query: 36  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
           VNGT+ +YE+EEITLERGNSGLGFSIAGGTDNPHIGDD  IFITKII GGAAA+DGRLRV
Sbjct: 213 VNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRV 272

Query: 96  NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
           NDCILRVNEVDV +V+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFS
Sbjct: 273 NDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFS 332

Query: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
           IAGGVGNQHIPGDNSIYVTKII+GGAA KDG+LQ+GD+LL VNN  LEEVTHEEAV  LK
Sbjct: 333 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALK 392

Query: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
           NTS+ VYLKV KPT++YM D Y PPDIT+S S P++NH+   +           P SP R
Sbjct: 393 NTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS------FLGQTPASPAR 446

Query: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG 335
           YSP+ K +L DD+ T                        EPRKVVLH+GSTGLGFNIVGG
Sbjct: 447 YSPVSKAVLGDDEITR-----------------------EPRKVVLHRGSTGLGFNIVGG 483

Query: 336 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIA 395
           EDGEGIF+SFILAGGPADLSGEL++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+A
Sbjct: 484 EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVA 543

Query: 396 QYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ 455
           QY+PE+Y+RFEAKIHDLREQMMN S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQ
Sbjct: 544 QYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQ 603

Query: 456 GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAK 515
           GL+FK+GDILHVINASDDEWWQAR+V  +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K
Sbjct: 604 GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSK 663

Query: 516 -------------------------------PGVIDSKGDIPGLGDDGYGTKTLRGQEDL 544
                                              D+   +     D     + RGQE+ 
Sbjct: 664 TRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASD--SESSYRGQEEY 721

Query: 545 ILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRD 604
           +LSYEPV +QE+NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRD
Sbjct: 722 VLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRD 781

Query: 605 YHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQ 664
           YHFV SREQMEKDIQEHKFIEAGQYN++LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ
Sbjct: 782 YHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQ 841

Query: 665 VAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLED 724
           +AQLYPI+IFIKP+S+E +MEMNKRLTEEQA+KT++RA+KLEQEF E+FTAIVQGDTLED
Sbjct: 842 IAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLED 901

Query: 725 IYNQCKLVIEEQSGPFIWIPSKEKL 749
           IYNQ K +IEEQSG +IW+P+KEKL
Sbjct: 902 IYNQVKQIIEEQSGSYIWVPAKEKL 926


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score =  978 bits (2529), Expect = 0.0
 Identities = 484/716 (67%), Positives = 581/716 (81%), Gaps = 43/716 (6%)

Query: 34  IPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRL 93
           + VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFITKIIPGGAAA+DGRL
Sbjct: 95  LQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRL 154

Query: 94  RVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLG 153
           RVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P  E V+EIKL KGPKGLG
Sbjct: 155 RVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLG 214

Query: 154 FSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAI 213
           FSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+  LE+V HE+AVA 
Sbjct: 215 FSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAA 274

Query: 214 LKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP 273
           LKNT +VVYLKV KP+  Y++D Y PPDIT SYS  ++N +   +    +Y T++ P SP
Sbjct: 275 LKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSP 334

Query: 274 GRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIV 333
            RYSP+ K +L ++D                       +  EPR++V+H+GSTGLGFNIV
Sbjct: 335 RRYSPVAKDLLGEED-----------------------IPREPRRIVIHRGSTGLGFNIV 371

Query: 334 GGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
           GGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK AGQTVTI
Sbjct: 372 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431

Query: 394 IAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLP 453
           IAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR  Y+RA+FDYDK+KD G  
Sbjct: 432 IAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFL 491

Query: 454 SQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFN 513
           SQ LSF++GD+LHVI+ASD+EWWQARRV  + +++++G IPSKRRVER+E +RLK   + 
Sbjct: 492 SQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWG 551

Query: 514 AKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRIN 573
           +  G                     +G+ED +LSYE VT+ E++Y RP+IILGP KDR N
Sbjct: 552 SSSG--------------------SQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN 591

Query: 574 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL 633
           DDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +L
Sbjct: 592 DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL 651

Query: 634 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE 693
           YGTSVQSVR VAE+GKHCILDVS NA++RLQ A L+PIAIFI+PRSLE ++E+NKR+TEE
Sbjct: 652 YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE 711

Query: 694 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
           QA+K +DRA KLEQEF E F+AIV+GD+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 712 QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score =  978 bits (2528), Expect = 0.0
 Identities = 484/714 (67%), Positives = 580/714 (81%), Gaps = 43/714 (6%)

Query: 36  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
           VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFITKIIPGGAAA+DGRLRV
Sbjct: 51  VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 110

Query: 96  NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
           ND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P  E V+EIKL KGPKGLGFS
Sbjct: 111 NDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFS 170

Query: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
           IAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+  LE+V HE+AVA LK
Sbjct: 171 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALK 230

Query: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
           NT +VVYLKV KP+  Y++D Y PPDIT SYS  ++N +   +    +Y T++ P SP R
Sbjct: 231 NTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 290

Query: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG 335
           YSP+ K +L ++D                       +  EPR++V+H+GSTGLGFNIVGG
Sbjct: 291 YSPVAKDLLGEED-----------------------IPREPRRIVIHRGSTGLGFNIVGG 327

Query: 336 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIA 395
           EDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK AGQTVTIIA
Sbjct: 328 EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIA 387

Query: 396 QYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ 455
           QY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR  Y+RA+FDYDK+KD G  SQ
Sbjct: 388 QYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ 447

Query: 456 GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAK 515
            LSF++GD+LHVI+ASD+EWWQARRV  + +++++G IPSKRRVER+E +RLK   + + 
Sbjct: 448 ALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSS 507

Query: 516 PGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD 575
            G                     +G+ED +LSYE VT+ E++Y RP+IILGP KDR NDD
Sbjct: 508 SG--------------------SQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDD 547

Query: 576 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG 635
           L+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +LYG
Sbjct: 548 LLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYG 607

Query: 636 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA 695
           TSVQSVR VAE+GKHCILDVS NA++RLQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA
Sbjct: 608 TSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQA 667

Query: 696 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
           +K +DRA KLEQEF E F+AIV+GD+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 668 RKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score =  693 bits (1788), Expect = 0.0
 Identities = 346/467 (74%), Positives = 399/467 (85%), Gaps = 32/467 (6%)

Query: 315 EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 374
           EPRK++LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR 
Sbjct: 46  EPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105

Query: 375 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKR 434
           A+HEQAAAALK AGQ+VTI+AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KR
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKR 165

Query: 435 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 494
           SLYVRA+FDYD+++DS LPSQGLSF YGDILHVINASDDEWWQAR V   G+SE++GVIP
Sbjct: 166 SLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIP 225

Query: 495 SKRRVERKERARLKTVKFNAKPGVIDSKGDIP--------------------------GL 528
           SK+RVE+KERARLKTVKF+A+ G+I+S   I                            +
Sbjct: 226 SKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSI 285

Query: 529 GDDGYGTKTL------RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPD 582
            + G  + T       +GQED ILSYEPVTRQEI+Y RPVIILGPMKDR+NDDLISEFP 
Sbjct: 286 QEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH 345

Query: 583 KFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVR 642
           KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEKDIQ++KFIEAGQ+NDNLYGTS+QSVR
Sbjct: 346 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 405

Query: 643 FVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRA 702
            VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIKP+S+E LMEMN+R T EQA K YD+A
Sbjct: 406 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKA 465

Query: 703 IKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
           +KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+QSG +IW+PS EKL
Sbjct: 466 MKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 48/136 (35%), Positives = 71/136 (52%), Gaps = 8/136 (5%)

Query: 44  EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
           E  +I L +G++GLGF+I GG D        GIF++ I+ GG A   G LR  D IL VN
Sbjct: 46  EPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVN 99

Query: 104 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGN 162
            V++   +H +A  ALK AG  V + V + RP   +  E K+     + +  S++ G G+
Sbjct: 100 GVNLRNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS 158

Query: 163 QHIPGDNSIYVTKIID 178
                  S+YV  + D
Sbjct: 159 LRTSEKRSLYVRALFD 174



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 12/122 (9%)

Query: 142 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201
           +I L KG  GLGF+I GG   +       I+V+ I+ GG A   G L+ GDR+L VN  +
Sbjct: 49  KIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVN 102

Query: 202 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGP-PDITHSYSPPMENHLLSGNNG 260
           L   THE+A A LK   + V +        Y  + Y       H     M N  +S  +G
Sbjct: 103 LRNATHEQAAAALKRAGQSVTI-----VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSG 157

Query: 261 TL 262
           +L
Sbjct: 158 SL 159


>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
          Length = 334

 Score =  676 bits (1743), Expect = 0.0
 Identities = 334/334 (100%), Positives = 334/334 (100%)

Query: 416 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 475
           MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW
Sbjct: 1   MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60

Query: 476 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGT 535
           WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGT
Sbjct: 61  WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGT 120

Query: 536 KTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 595
           KTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK
Sbjct: 121 KTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 180

Query: 596 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 655
           RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV
Sbjct: 181 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 240

Query: 656 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTA 715
           SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTA
Sbjct: 241 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTA 300

Query: 716 IVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
           IVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Sbjct: 301 IVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334


>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
          Length = 675

 Score =  207 bits (526), Expect = 4e-53
 Identities = 148/459 (32%), Positives = 227/459 (49%), Gaps = 65/459 (14%)

Query: 314 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 373
           GE  K+V  + +  +        + + + +S I+ GG A+ SG L  GD++L +NGI++R
Sbjct: 251 GETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310

Query: 374 GASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTN 431
           G    +    L     T+T  +I   Q +     E  IH                     
Sbjct: 311 GKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH--------------------- 349

Query: 432 QKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEE 489
                 V+A FDYD S D  +P +  GLSF+ GDILHVI+  D  WWQA R   E +   
Sbjct: 350 ------VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPL 403

Query: 490 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDI---------------PGLGDDGYG 534
            G++P K   +++E A  +T++ + +P   +  G +                   +D Y 
Sbjct: 404 AGLVPGKSFQQQRE-AMKQTIEEDKEP---EKSGKLWCAKKNKKKRKKVLYNANKNDDYD 459

Query: 535 TKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHT 591
            + +   E++ L ++P  R+     RP+I++GP    ++ +   L+++  D+F S VPHT
Sbjct: 460 NEEILTYEEMSLYHQPANRK-----RPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHT 514

Query: 592 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 651
           TR +RD EV GRDYHFV SR+  E DI   KFIE G++  NLYGTS+ SVR V   GK C
Sbjct: 515 TRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKIC 573

Query: 652 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTYDRAIKLEQ 707
           +L +   ++K L+ + L P  IFI P S E L  +     K    E+ ++  ++  ++EQ
Sbjct: 574 LLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQ 633

Query: 708 EFGEYF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
             G YF TAIV  D L+  Y +   +I +      W+PS
Sbjct: 634 NNGHYFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 15/48 (31%), Positives = 27/48 (56%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216
           +S+ +++I+ GGAA+K G L  GD +L +N   +      E   +L +
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSD 323


>gi|95089461 discs large homolog 5 [Homo sapiens]
          Length = 1919

 Score =  189 bits (480), Expect = 8e-48
 Identities = 167/647 (25%), Positives = 294/647 (45%), Gaps = 101/647 (15%)

Query: 131  RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 190
            R+ RP +E    +K+ KG + LG SI  G           IYV+K+  G  A + G L+ 
Sbjct: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390

Query: 191  GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 250
            GD+LL  N  +L   T ++A  I+    + +       T +   +P+     +HS S   
Sbjct: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTI-------TILAQYNPHVHQLSSHSRS--- 1440

Query: 251  ENHL-LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRA 309
             +HL  +G + TL+   +  P  P    P+   M  D+  ++     +++R      ++ 
Sbjct: 1441 SSHLDPAGTHSTLQGSGTTTPEHPSVIDPL---MEQDEGPSTPPAKQSSSRIAGDANKKT 1497

Query: 310  VSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNG 369
            +    EPR V + K    LG ++ GG +  G+FV+ +    PA     L  GD IL    
Sbjct: 1498 L----EPRVVFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGS 1552

Query: 370  IDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR 429
            +D+R  + E+    +      V +  QY+PE++ + +    D                  
Sbjct: 1553 LDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD------------------ 1594

Query: 430  TNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGD 486
                 S Y+RA+  YD+  D     Q LSFK  DIL+V +         W A ++     
Sbjct: 1595 -----SFYIRAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQ 1644

Query: 487  SEEMGVIPSKRRVERKERARL------------KTVKFNAKPGVIDSK------GDIPG- 527
              + G IPSK  ++++   RL            KT+   A+      K      G   G 
Sbjct: 1645 KIQRGQIPSKYVMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGK 1704

Query: 528  --LGDDGYGTKTLRGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF 584
              L  D + + ++   ED + L+Y+ V + +    RPV+ILGP+ D + + L++E P KF
Sbjct: 1705 DLLALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKF 1764

Query: 585  GSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 644
              C     +                S++ +E+ +++  F++  + + +   T+V S++ +
Sbjct: 1765 CRCPLEVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEI 1809

Query: 645  AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKT 698
             E+ +HC+LD++ +AI+RL    +YPI IFI  +S + + E      +  ++T+  +K+ 
Sbjct: 1810 TEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQ 1869

Query: 699  YDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
            ++ A KLEQE+  YFT ++QG  L  I  Q   ++ ++    +WIP+
Sbjct: 1870 FEAAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916



 Score =  100 bits (248), Expect = 6e-21
 Identities = 64/191 (33%), Positives = 102/191 (53%), Gaps = 21/191 (10%)

Query: 40  EIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
           E E E E+I L+     LGF +A G + P    D GIF+TK+  G  A  DGRLRVND +
Sbjct: 622 EFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWL 675

Query: 100 LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI---LETVVEIKLFKGPKGLGFSI 156
           LR+N+VD+      +A++AL      + + VRRR+ +   + T + I L  G K  G S+
Sbjct: 676 LRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-SGQKDSGISL 734

Query: 157 AGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216
                      +N +Y   ++ G  A K+G L VGDR++ +N  +L+  +  E  ++L++
Sbjct: 735 -----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRS 783

Query: 217 TSEVVYLKVGK 227
             + + L + K
Sbjct: 784 CQDSLTLSLLK 794



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 5/90 (5%)

Query: 309 AVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQ 363
           A+++    RK +  K  T L  N+ G +D       G++ + +L G PA   G L  GD+
Sbjct: 701 AINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDR 760

Query: 364 ILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
           I+++NGI L   S  +  + L+    ++T+
Sbjct: 761 IVAINGIALDNKSLNECESLLRSCQDSLTL 790


>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
          Length = 576

 Score =  184 bits (466), Expect = 3e-46
 Identities = 139/475 (29%), Positives = 215/475 (45%), Gaps = 81/475 (17%)

Query: 313 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 372
           E   + + L K    LG  I   E    I V+ I+ GG AD SG +  GD++  VNGI +
Sbjct: 134 EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPV 193

Query: 373 RGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQ 432
                E+           + I+AQ Q                  +   +  GS     ++
Sbjct: 194 EDKRPEEI----------IQILAQSQGA----------------ITFKIIPGSKEETPSK 227

Query: 433 KRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-E 489
           +  ++++A+FDY+ ++D  +P +  GLSFK GDIL +++  D  WWQA+    E D+   
Sbjct: 228 EGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH---EADANPR 284

Query: 490 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKTLRGQEDL----- 544
            G+IPSK   ER+   R        +P ++     +      G+       ++D      
Sbjct: 285 AGLIPSKHFQERRLALR--------RPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKS 336

Query: 545 --------------ILSYEPVT---RQEINYTRPVIILGPMKDRIND---DLISEFPDKF 584
                         + +YE VT   RQ     R V+++GP+   +N+    L+      +
Sbjct: 337 MYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHY 396

Query: 585 GSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 644
           G  VPHTTR +R  E DG +Y F IS+   E D+Q +KFIE G+Y +N YGTS+ SVR V
Sbjct: 397 GVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSV 455

Query: 645 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR--------------- 689
             + K C+LDV  + +K L+  +  P  IFIKP S+E L E  K                
Sbjct: 456 LAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKP 515

Query: 690 LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
            TEE  ++    A  +E ++G  F  I+  D L   +N+ K   ++      W+P
Sbjct: 516 FTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 6/88 (6%)

Query: 138 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 197
           ++V  I+L K  + LG +I      +      +I V +I+ GGAA + G + VGD L  V
Sbjct: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188

Query: 198 NNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           N   +E+   EE + IL  +   +  K+
Sbjct: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216


>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
          Length = 585

 Score =  183 bits (464), Expect = 6e-46
 Identities = 138/475 (29%), Positives = 229/475 (48%), Gaps = 81/475 (17%)

Query: 319 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378
           V L K    LG  I   E    + V+ I+ GG AD SG +  GD++  VNGI +     +
Sbjct: 138 VRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPD 197

Query: 379 QAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 436
           + +  L  +  ++T  II   Q ED  + E+K+                           
Sbjct: 198 EISQILAQSQGSITLKIIPATQEEDRLK-ESKV--------------------------- 229

Query: 437 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-EMGVI 493
           ++RA+F Y+  +D  +P Q  GL F+   +L V++  D  WWQA+RV   GD+    G+I
Sbjct: 230 FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRV---GDTNLRAGLI 286

Query: 494 PSKRRVERKERAR-----LKTVKFNAKPG--------VIDSKGDIPG------------- 527
           PSK   ER+   R     L + +   KP           D +G + G             
Sbjct: 287 PSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLG 346

Query: 528 ----LGDDGYGTKTLRGQEDLILSYEPVTR---QEINYTRPVIILGPMKDRIND---DLI 577
               LG    G  +   +   +L+YE V R   Q     R V+++G +  R+++    ++
Sbjct: 347 CRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKVV 406

Query: 578 SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS 637
           +E P  FG  VPHTTRP++ +E +G +YHFV S++  E D+  +KF+E G+Y +NLYGTS
Sbjct: 407 AENPQHFGVAVPHTTRPRKSHEKEGVEYHFV-SKQAFEADLHHNKFLEHGEYKENLYGTS 465

Query: 638 VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR--------SLEPLMEMNKR 689
           +++++ V  + K C++DV   A+K+L+ ++  P  IF+KP          + P  E    
Sbjct: 466 LEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACEDTAA 525

Query: 690 LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
             +EQ ++    A  +++ +G    A++  + L+  Y+Q K+V+E+ S    W+P
Sbjct: 526 PFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVP 580



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 6/88 (6%)

Query: 138 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 197
           E+V  ++L K  + LG +I     ++H     ++ V +I+ GGAA + G + VGD L  V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186

Query: 198 NNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           N  ++     +E   IL  +   + LK+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKI 214


>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
          Length = 552

 Score =  172 bits (437), Expect = 8e-43
 Identities = 143/524 (27%), Positives = 230/524 (43%), Gaps = 86/524 (16%)

Query: 241 DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300
           ++ H    P    LL  ++         PP SPG   P   +  V  D            
Sbjct: 90  ELAHILQEPHFQSLLETHDSVASKTYETPPPSPG-LDPTFSNQPVPPD------------ 136

Query: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQR 360
                   AV + G  +    H G T   F + GGE    + ++ IL GG     G L  
Sbjct: 137 --------AVRMVGIRKTAGEHLGVT---FRVEGGE----LVIARILHGGMVAQQGLLHV 181

Query: 361 GDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMN 418
           GD I  VNG  + G+        L+ A  +V   I+  YQ                    
Sbjct: 182 GDIIKEVNGQPV-GSDPRALQELLRNASGSVILKILPSYQ-------------------- 220

Query: 419 HSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWW 476
                       +  R ++V+  FDYD ++DS +P +  GL F  GD+L ++N  D  WW
Sbjct: 221 ----------EPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWW 270

Query: 477 QARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY--- 533
           QA  V  EG S   G+IPS+   E+++    + ++     G +   G + G         
Sbjct: 271 QACHV--EGGSA--GLIPSQLLEEKRKAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYL 324

Query: 534 GTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPH 590
            TK        +L YE V R      + ++++G     +  + + LI   PD++G+ VP+
Sbjct: 325 TTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPY 384

Query: 591 TTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKH 650
           T+R  +D E +G+ Y FV SR +ME D++  +++E G+Y  NLYGT + S+R V   GK 
Sbjct: 385 TSRRPKDSEREGQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKV 443

Query: 651 CILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYD 700
           C+LDV+  A+K L+ A+  P  +FI+    E L  MN          K+LTE   ++T +
Sbjct: 444 CVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVE 503

Query: 701 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
            + ++++ +G YF   +    LE  + + +  +E+      W+P
Sbjct: 504 ESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547


>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
          Length = 540

 Score =  164 bits (416), Expect = 2e-40
 Identities = 124/427 (29%), Positives = 201/427 (47%), Gaps = 58/427 (13%)

Query: 337 DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--II 394
           +   + ++ IL GG  D  G L  GD I  VNG ++ G + ++    LK    +VT  I+
Sbjct: 148 ENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNISGSVTLKIL 206

Query: 395 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 454
             Y+                               T   + ++V+  FDY+   D+ +P 
Sbjct: 207 PSYRD------------------------------TITPQQVFVKCHFDYNPYNDNLIPC 236

Query: 455 Q--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKF 512
           +  GL F  G+IL ++N  D  WWQA  V   G +   G+IPS+  +E K +A ++    
Sbjct: 237 KEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSA---GLIPSQF-LEEKRKAFVRRDWD 292

Query: 513 NAKP--GVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM-- 568
           N+ P  G I SK     +      T+        I  YE V +      + ++++G    
Sbjct: 293 NSGPFCGTISSKKKKKMMY---LTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGV 349

Query: 569 -KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAG 627
            +  + +  I   P +FG+ VP T+R  R+ E DG+ Y FV SR +ME DI+  K++E G
Sbjct: 350 GRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFV-SRSEMEADIKAGKYLEHG 408

Query: 628 QYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMN 687
           +Y  NLYGT + S+  V + G+ CILDV+  A+K L+ ++  P  +FI    LE L  M+
Sbjct: 409 EYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMH 468

Query: 688 KR----------LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQS 737
           K           LT+   KKT D + ++++ +  YF  I+  D L+  + + +  IE+  
Sbjct: 469 KAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLR 528

Query: 738 GPFIWIP 744
               W+P
Sbjct: 529 MEPQWVP 535



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 19/58 (32%), Positives = 31/58 (53%), Gaps = 1/58 (1%)

Query: 168 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           +N + + +I+ GG   + G L VGD +  VN + +     +E   +LKN S  V LK+
Sbjct: 149 NNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGN-NPKELQELLKNISGSVTLKI 205


>gi|186972120 calcium/calmodulin-dependent serine protein kinase
           isoform 1 [Homo sapiens]
          Length = 921

 Score =  157 bits (398), Expect = 3e-38
 Identities = 113/414 (27%), Positives = 200/414 (48%), Gaps = 24/414 (5%)

Query: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 400
           V+ I+ GG     G L  GD+I  +NGI +   + EQ    L+    ++T  I+  Y+ +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574

Query: 401 DYARFEAKIHDLREQMMN-HSMSSGSGS---LRTNQK-RSLYVRAMFDYDKSKDSGLPSQ 455
             +         R+   N HS ++ S S     T  K R +YVRA F+YD +KD  +P +
Sbjct: 575 SSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCK 634

Query: 456 --GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFN 513
             G+ F+ GDI+ +I+  D  WWQ +  +    +   G+IPS    E     R+  +   
Sbjct: 635 EAGIRFRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEW----RVACIAME 688

Query: 514 AKPGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KD 570
                  +     G     Y  K L      +++YE V +      + +++LG     + 
Sbjct: 689 KTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRR 748

Query: 571 RINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYN 630
            I + LI++ PD+F   +PHTTRP +  E +G++Y+FV S +QM +DI  ++++E G + 
Sbjct: 749 HIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGSHE 807

Query: 631 DNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL 690
           D +YGT ++++R + E+G   ILDV   A+K L+ A+  P  +FI   ++ P +  ++ L
Sbjct: 808 DAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESL 867

Query: 691 TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
              Q +        L++ +  YF   +  + +++     +  +E       W+P
Sbjct: 868 QRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 916



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 16/57 (28%), Positives = 27/57 (47%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           N   V +I+ GG   + G L VGD +  +N  S+   T E+   +L+     +  K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567


>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
          Length = 466

 Score =  153 bits (386), Expect = 6e-37
 Identities = 112/413 (27%), Positives = 191/413 (46%), Gaps = 58/413 (14%)

Query: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 402
           V+ IL GG     G L  GD+IL +NG ++   S +Q   A+K     +++  +  P   
Sbjct: 96  VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153

Query: 403 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFK 460
           +R  A                            +++RA FDYD  KD+ +P +  GL F 
Sbjct: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187

Query: 461 YGDILHVINASDDEWWQARRVMLEGDSEE-MGVIPSKRRVERKERARLKTVKFNAKPGVI 519
            GDI+ +IN  D  WWQ R   +EG S+E  G+IPS    E +       V   A+    
Sbjct: 188 TGDIIQIINKDDSNWWQGR---VEGSSKESAGLIPSPELQEWR-------VASMAQSAPS 237

Query: 520 DSKGDIPGLGDDGYGTKTLRGQEDL-----ILSYEPVTRQEINYTRPVIILGPM---KDR 571
           ++    P      Y  K L     +     ++SYE V R      + ++++G     +  
Sbjct: 238 EAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSH 297

Query: 572 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYND 631
           I + L+S+ P+KF   VP+TTRP R  E DG++YHF IS E+M ++I  ++F+E G Y  
Sbjct: 298 IKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNISANEFLEFGSYQG 356

Query: 632 NLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLT 691
           N++GT  ++V  + ++ K  ILD+    +K ++ A+L P  +FI P       E  ++L 
Sbjct: 357 NMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQ 416

Query: 692 EEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
           ++           +  ++  YF   +  + +++   + +   ++      W+P
Sbjct: 417 KDSE--------AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 17/56 (30%), Positives = 30/56 (53%)

Query: 170 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           S  V +I+ GG   + G L VGD +L +N  ++   + ++    +K T  ++ LKV
Sbjct: 93  SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 78  ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV----RRR 133
           + +I+ GG     G L V D IL +N  +V+  S  +  +A+KE   ++ L V    + R
Sbjct: 96  VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155

Query: 134 RPILETVVEIKLFKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 185
            P L+  +  +    P        K  G   A G   Q I  D+S +    ++G + +  
Sbjct: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215

Query: 186 G 186
           G
Sbjct: 216 G 216


>gi|186700627 calcium/calmodulin-dependent serine protein kinase
           isoform 2 [Homo sapiens]
          Length = 898

 Score =  152 bits (384), Expect = 1e-36
 Identities = 107/409 (26%), Positives = 194/409 (47%), Gaps = 37/409 (9%)

Query: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 400
           V+ I+ GG     G L  GD+I  +NGI +   + EQ    L+    ++T  I+  Y+ +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574

Query: 401 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLS 458
             +          E + + +   G         R +YVRA F+YD +KD  +P +  G+ 
Sbjct: 575 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 616

Query: 459 FKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGV 518
           F+ GDI+ +I+  D  WWQ +  +    +   G+IPS    E     R+  +        
Sbjct: 617 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEW----RVACIAMEKTKQE 670

Query: 519 IDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDD 575
             +     G     Y  K L      +++YE V +      + +++LG     +  I + 
Sbjct: 671 QQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNT 730

Query: 576 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG 635
           LI++ PD+F   +PHTTRP +  E +G++Y+FV S +QM +DI  ++++E G + D +YG
Sbjct: 731 LITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGSHEDAMYG 789

Query: 636 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA 695
           T ++++R + E+G   ILDV   A+K L+ A+  P  +FI   ++ P +  ++ L   Q 
Sbjct: 790 TKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQK 849

Query: 696 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
           +        L++ +  YF   +  + +++     +  +E       W+P
Sbjct: 850 ESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 893



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 16/57 (28%), Positives = 27/57 (47%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           N   V +I+ GG   + G L VGD +  +N  S+   T E+   +L+     +  K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  152 bits (384), Expect = 1e-36
 Identities = 133/416 (31%), Positives = 194/416 (46%), Gaps = 91/416 (21%)

Query: 36   VNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPGGAAAEDGRLR 94
            +    IE E   +T+ R   GLG SIAGG  + P+ GDD GIFI+++   G AA  G +R
Sbjct: 717  IEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775

Query: 95   VNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEIK--------- 144
            V D +L VN V +    H +AVEAL+ AG+ V++ V R R +  E  V I          
Sbjct: 776  VGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYS 835

Query: 145  -----------------------------LFKGPKGLGFSIAGGVGNQ-HIPGDNSIYVT 174
                                         L +  +GLGFSIAGG G+  +  GD  I+V+
Sbjct: 836  PRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVS 895

Query: 175  KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234
            +I +GGAA + G LQVGDR+L +N   + E  H+ AV++L   S  + L + +       
Sbjct: 896  RIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA----G 951

Query: 235  DPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQ 294
             P  P  + HS SPP      +    T    T+ P + PG  S  P  +           
Sbjct: 952  GPLPPSPLPHS-SPP------TAAVATTSITTATPGV-PGLPSLAPSLL----------- 992

Query: 295  HSTATRQPSMTLQRAVSLEG--EPRKVVLHKGSTGLGFNIVGGEDGE---------GIFV 343
                          A +LEG     ++ L +    LG +IVGG D           G+F+
Sbjct: 993  --------------AAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038

Query: 344  SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 399
            S +L  G A  SG L+ GD+IL+VNG D+R A+H++A +AL      ++++ +  P
Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093



 Score =  124 bits (311), Expect = 3e-28
 Identities = 98/258 (37%), Positives = 134/258 (51%), Gaps = 26/258 (10%)

Query: 43   YEFEEITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
            Y  EEI L R    LG SI GG+D+   P    +PG+FI+K++P G AA  G LRV D I
Sbjct: 1000 YPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRI 1058

Query: 100  LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGP-KGLGFSIAG 158
            L VN  DV + +H +AV AL      + L VRR  P    + E+ + K P + LG SI G
Sbjct: 1059 LAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD-PAPPGLRELCIQKAPGERLGISIRG 1117

Query: 159  GV----GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 214
            G     GN   P D  I+++K+   GAA +DGRL+VG RLL VN  SL  +TH EAV +L
Sbjct: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177

Query: 215  KNTSEVVYLKVGKPTTIYMTDPY-GPPDITHSYSPPMENHLLS---GNNGTLEYKTS--- 267
            ++        VG   T+ + D +    D     SP +  +  +   G+  +LE  +S   
Sbjct: 1178 RS--------VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDR 1229

Query: 268  -LPPISPGRYSPIPKHML 284
             L P  PG+   +P   L
Sbjct: 1230 ELSPEGPGKEKELPGQTL 1247



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 8/98 (8%)

Query: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPAD 353
           Q +  L     +E E   + + + + GLG +I GG+       D EGIF+S +   GPA 
Sbjct: 711 QANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAA 770

Query: 354 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 391
            +G ++ GD++L VNG+ L+GA H +A  AL+GAG  V
Sbjct: 771 RAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 47/181 (25%), Positives = 81/181 (44%), Gaps = 17/181 (9%)

Query: 291  SHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-STGLGFNIVGGEDG-------- 338
            +H +  +A  +P + L   V  +  P   R++ + K     LG +I GG  G        
Sbjct: 1070 THQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDP 1129

Query: 339  --EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
              EGIF+S +   G A   G L+ G ++L VN   L G +H +A   L+  G T+T++  
Sbjct: 1130 TDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189

Query: 397  YQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQG 456
               E  A  +A + ++   ++ +  ++G G   + +  S   R +      K+  LP Q 
Sbjct: 1190 DGFE--ASTDAAL-EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQT 1246

Query: 457  L 457
            L
Sbjct: 1247 L 1247


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  152 bits (384), Expect = 1e-36
 Identities = 133/416 (31%), Positives = 194/416 (46%), Gaps = 91/416 (21%)

Query: 36   VNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPGGAAAEDGRLR 94
            +    IE E   +T+ R   GLG SIAGG  + P+ GDD GIFI+++   G AA  G +R
Sbjct: 717  IEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VR 775

Query: 95   VNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-ETVVEIK--------- 144
            V D +L VN V +    H +AVEAL+ AG+ V++ V R R +  E  V I          
Sbjct: 776  VGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYS 835

Query: 145  -----------------------------LFKGPKGLGFSIAGGVGNQ-HIPGDNSIYVT 174
                                         L +  +GLGFSIAGG G+  +  GD  I+V+
Sbjct: 836  PRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVS 895

Query: 175  KIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234
            +I +GGAA + G LQVGDR+L +N   + E  H+ AV++L   S  + L + +       
Sbjct: 896  RIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREA----G 951

Query: 235  DPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQ 294
             P  P  + HS SPP      +    T    T+ P + PG  S  P  +           
Sbjct: 952  GPLPPSPLPHS-SPP------TAAVATTSITTATPGV-PGLPSLAPSLL----------- 992

Query: 295  HSTATRQPSMTLQRAVSLEG--EPRKVVLHKGSTGLGFNIVGGEDGE---------GIFV 343
                          A +LEG     ++ L +    LG +IVGG D           G+F+
Sbjct: 993  --------------AAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038

Query: 344  SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 399
            S +L  G A  SG L+ GD+IL+VNG D+R A+H++A +AL      ++++ +  P
Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP 1093



 Score =  124 bits (311), Expect = 3e-28
 Identities = 98/258 (37%), Positives = 134/258 (51%), Gaps = 26/258 (10%)

Query: 43   YEFEEITLERGNSGLGFSIAGGTDN---PHIGDDPGIFITKIIPGGAAAEDGRLRVNDCI 99
            Y  EEI L R    LG SI GG+D+   P    +PG+FI+K++P G AA  G LRV D I
Sbjct: 1000 YPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRI 1058

Query: 100  LRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGP-KGLGFSIAG 158
            L VN  DV + +H +AV AL      + L VRR  P    + E+ + K P + LG SI G
Sbjct: 1059 LAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD-PAPPGLRELCIQKAPGERLGISIRG 1117

Query: 159  GV----GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAIL 214
            G     GN   P D  I+++K+   GAA +DGRL+VG RLL VN  SL  +TH EAV +L
Sbjct: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177

Query: 215  KNTSEVVYLKVGKPTTIYMTDPY-GPPDITHSYSPPMENHLLS---GNNGTLEYKTS--- 267
            ++        VG   T+ + D +    D     SP +  +  +   G+  +LE  +S   
Sbjct: 1178 RS--------VGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDR 1229

Query: 268  -LPPISPGRYSPIPKHML 284
             L P  PG+   +P   L
Sbjct: 1230 ELSPEGPGKEKELPGQTL 1247



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 8/98 (8%)

Query: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGE-------DGEGIFVSFILAGGPAD 353
           Q +  L     +E E   + + + + GLG +I GG+       D EGIF+S +   GPA 
Sbjct: 711 QANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAA 770

Query: 354 LSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 391
            +G ++ GD++L VNG+ L+GA H +A  AL+GAG  V
Sbjct: 771 RAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAV 807



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 47/181 (25%), Positives = 81/181 (44%), Gaps = 17/181 (9%)

Query: 291  SHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-STGLGFNIVGGEDG-------- 338
            +H +  +A  +P + L   V  +  P   R++ + K     LG +I GG  G        
Sbjct: 1070 THQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDP 1129

Query: 339  --EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
              EGIF+S +   G A   G L+ G ++L VN   L G +H +A   L+  G T+T++  
Sbjct: 1130 TDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189

Query: 397  YQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQG 456
               E  A  +A + ++   ++ +  ++G G   + +  S   R +      K+  LP Q 
Sbjct: 1190 DGFE--ASTDAAL-EVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQT 1246

Query: 457  L 457
            L
Sbjct: 1247 L 1247


>gi|186700629 calcium/calmodulin-dependent serine protein kinase
           isoform 3 [Homo sapiens]
          Length = 897

 Score =  150 bits (378), Expect = 5e-36
 Identities = 109/411 (26%), Positives = 195/411 (47%), Gaps = 36/411 (8%)

Query: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 400
           V+ I+ GG     G L  GD+I  +NGI +   + EQ    L+    ++T  I+  Y+ +
Sbjct: 509 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 568

Query: 401 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLS 458
             +          E + + +   G         R +YVRA F+YD +KD  +P +  G+ 
Sbjct: 569 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 610

Query: 459 FKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGV 518
           F+ GDI+ +I+  D  WWQ +  +    +   G+IPS    E +            +   
Sbjct: 611 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQAS 668

Query: 519 IDSKGDIPGLGDDGYGTK--TLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRIN 573
               G       D Y  K   +  Q DL+ +YE V +      + +++LG     +  I 
Sbjct: 669 CTWFGKKKKQYKDKYLAKHNAVFDQLDLV-TYEEVVKLPAFKRKTLVLLGAHGVGRRHIK 727

Query: 574 DDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNL 633
           + LI++ PD+F   +PHTTRP +  E +G++Y+FV S +QM +DI  ++++E G + D +
Sbjct: 728 NTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQDISNNEYLEYGSHEDAM 786

Query: 634 YGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE 693
           YGT ++++R + E+G   ILDV   A+K L+ A+  P  +FI   ++ P +  ++ L   
Sbjct: 787 YGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRL 846

Query: 694 QAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
           Q +        L++ +  YF   +  + +++     +  +E       W+P
Sbjct: 847 QKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 892



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 16/57 (28%), Positives = 27/57 (47%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
           N   V +I+ GG   + G L VGD +  +N  S+   T E+   +L+     +  K+
Sbjct: 505 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 561


>gi|10092691 tight junction protein 3 [Homo sapiens]
          Length = 952

 Score =  149 bits (377), Expect = 7e-36
 Identities = 156/642 (24%), Positives = 255/642 (39%), Gaps = 138/642 (21%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 228
           + I++  I D G A +   LQ GD +L +N  S + ++  +   +++ +   + L V + 
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290

Query: 229 TTIYMTDPYGPPDITHSYSPPME------NHLLSGNNGTLEYKTSLPPISPGRYSPIPKH 282
              ++ +   PP ++ S S P+E      + + S      +  + L    P    P P+H
Sbjct: 291 RGQFLVNI--PPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRH 348

Query: 283 MLVDDD--YTSHSQHSTATRQPSMTLQRAVSLEGEPR----------------------- 317
                +   T     S   R+ S    R +S   E R                       
Sbjct: 349 AQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408

Query: 318 ------KVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
                 +VV       +G  + GG D  GIFVS + AG PAD  G +Q GDQIL VN + 
Sbjct: 409 GYSPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466

Query: 372 LRGASHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSL 428
            +  + E+A   L G   G+ + ++ Q + + + +  ++++ D                 
Sbjct: 467 FQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGD----------------- 509

Query: 429 RTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINA---------SDDEWWQAR 479
                 S Y+R  F+ + S     P  GL F  GD+ HV++          +    W A 
Sbjct: 510 ------SFYIRTHFELEPS-----PPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAV 558

Query: 480 RVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVI---DSKGDIPGLGDDGYGTK 536
           R+  +   +E G+IP++ R E+              PG     +++ +   L     G K
Sbjct: 559 RMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAK 618

Query: 537 --TLRGQEDLIL--------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF-- 584
             T R +EDL           YE V  +E ++ RPV+ILGP+ D     L +E PD+F  
Sbjct: 619 KTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEI 678

Query: 585 GSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFV 644
              V  T  P +  ++D                                      +VR +
Sbjct: 679 AETVSRTDSPSKIIKLD--------------------------------------TVRVI 700

Query: 645 AERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDR 701
           AE+ KH +LDV+ +AI+RL   Q YPI +F  P S   L  + + L   +    ++ Y +
Sbjct: 701 AEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQ 760

Query: 702 AIKLEQEFGEYFTAIVQ-GDTLEDIYNQCKLVIEEQSGPFIW 742
           A KL +     FTA +    T +  Y + K +I EQ    IW
Sbjct: 761 AQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 72/253 (28%), Positives = 106/253 (41%), Gaps = 38/253 (15%)

Query: 145 LFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203
           L K P+ G G +I+GG   +  PG  S+ V+ ++ GG A+  GRLQ GD ++MVN  S+E
Sbjct: 33  LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86

Query: 204 EVTHEEAVAILKNTSEVVYLKVGKPTTIYM----TDPYGP--PDITHSYSPP-------- 249
             T   A+ ILK  +++  + V +P  I++      P  P   D      P         
Sbjct: 87  NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146

Query: 250 --MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQH----STATRQPS 303
              +    SG+  + + ++  P   PGR      H        S +      S   R P 
Sbjct: 147 RGYDGDSSSGSGRSWDERSRRP--RPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPR 204

Query: 304 MTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQ 363
             +Q       +P K VL K      F   G + G  IF+  I   G A     LQ GD 
Sbjct: 205 QDVQM------KPVKSVLVKRRDSEEF---GVKLGSQIFIKHITDSGLAARHRGLQEGDL 255

Query: 364 ILSVNGIDLRGAS 376
           IL +NG+  +  S
Sbjct: 256 ILQINGVSSQNLS 268



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 26/81 (32%), Positives = 44/81 (54%), Gaps = 6/81 (7%)

Query: 56  GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 115
           G G +I+GG D P       + ++ ++PGG A  +GRL+  D I+ VN V +   + + A
Sbjct: 40  GFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFA 93

Query: 116 VEALKEAGSIVRLYVRRRRPI 136
           ++ LK    +  + V+R R I
Sbjct: 94  IQILKTCTKMANITVKRPRRI 114



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 12/81 (14%)

Query: 307 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGED--GEGIFVSFILAGGPADLSGELQRGDQI 364
           Q   +L  +PR+        G G  I GG D  G  + VS ++ GGPA+  G LQ GD I
Sbjct: 28  QHTATLSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHI 77

Query: 365 LSVNGIDLRGASHEQAAAALK 385
           + VNG+ +  A+   A   LK
Sbjct: 78  VMVNGVSMENATSAFAIQILK 98



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 9/72 (12%)

Query: 143 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
           ++  KG K +G  +AGG        D  I+V+ +  G  A   G +Q GD++L VN+   
Sbjct: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467

Query: 203 EEVTHEEAVAIL 214
           + +T EEAV  L
Sbjct: 468 QNLTREEAVQFL 479


>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
           [Homo sapiens]
          Length = 1043

 Score =  135 bits (339), Expect = 2e-31
 Identities = 156/632 (24%), Positives = 257/632 (40%), Gaps = 128/632 (20%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 225
           + I+V ++   G A KDG L  GD +L +N    E ++  +A  +++ +    ++V L+ 
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384

Query: 226 GKPTTIYMT---------DPYGPPDITHSYSPPMENHLLS-----GNNGTLEYKTSLPPI 271
            + T I +          +     +   S+SP    H  S      ++  L+ + S    
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444

Query: 272 SPGRYS-------------PIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAV-------S 311
           +P R S              I   ++ + +     Q      QP    +  +       +
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEA 504

Query: 312 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
           + G   K+V  K    +G  + GG D  GIFV+ I  G  A+  G LQ GDQIL VN  D
Sbjct: 505 IYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQD 562

Query: 372 LRGASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR 429
            RG   E A   L     G+ VTI+AQ + + Y                  ++ G G   
Sbjct: 563 FRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDI---------------LACGRGD-- 605

Query: 430 TNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGD 486
                S ++R+ F+ +K        Q L+F  G++  V++   D     W A R+   G+
Sbjct: 606 -----SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRI---GN 652

Query: 487 SEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKT--LRGQEDL 544
             E G+IP+K R E+    +      NA+      + D   +     G K    + +EDL
Sbjct: 653 ELEKGLIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDL 706

Query: 545 IL---------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 595
                      +YE V  +E  + RPV++ GP+ D   + L +E PD F +     T P 
Sbjct: 707 TAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP- 762

Query: 596 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 655
                               KD    K     + N         +VR + E+ KH +LDV
Sbjct: 763 --------------------KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDV 793

Query: 656 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEY 712
           +  A+  L   Q +PI IF  P S + +  M +RL   + + ++K +D+A KL++     
Sbjct: 794 TPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHL 853

Query: 713 FTAIVQGDTLEDI-YNQCKLVIEEQSGPFIWI 743
           FTA +  ++  D  +   K  I+ Q G  +W+
Sbjct: 854 FTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)

Query: 40  EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 97
           E+ +E   +TL++ +  G G +++GG DNPH    +  I I+ ++PGG A  DG L+ ND
Sbjct: 26  ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83

Query: 98  CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
            ++ VN   + +V HS AV+ L+++G +  + V+R R +
Sbjct: 84  RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)

Query: 150 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 208
           +G G +++GG  N H   G+ SI ++ ++ GG A  DG LQ  DR++MVN   +E+V H 
Sbjct: 42  RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99

Query: 209 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 242
            AV  L+ + +V  + V +P  + +      P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)

Query: 315 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 366
           E   V L K S  G G  + GG D      GE  I +S +L GGPAD  G LQ  D+++ 
Sbjct: 30  EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87

Query: 367 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
           VNG  +    H  A   L+ +G+   I+ +
Sbjct: 88  VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 8/69 (11%)

Query: 146 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205
           FK    +G  +AGG        D  I+V  I +G +A+++G LQ GD++L VN      +
Sbjct: 515 FKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGL 566

Query: 206 THEEAVAIL 214
             E+AV  L
Sbjct: 567 VREDAVLYL 575



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 48  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
           +  ++G+S +G  +AGG       +D GIF+  I  G +A ++G L+  D IL+VN  D 
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563

Query: 108 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 141
             +    AV  L E   G +V +  + R  +   ++
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 16/57 (28%), Positives = 31/57 (54%)

Query: 76  IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
           IF+ ++   G A +DG L   D IL++N      +S + A + ++++   ++L V R
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383


>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
           [Homo sapiens]
          Length = 1190

 Score =  135 bits (339), Expect = 2e-31
 Identities = 156/632 (24%), Positives = 257/632 (40%), Gaps = 128/632 (20%)

Query: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 225
           + I+V ++   G A KDG L  GD +L +N    E ++  +A  +++ +    ++V L+ 
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384

Query: 226 GKPTTIYMT---------DPYGPPDITHSYSPPMENHLLS-----GNNGTLEYKTSLPPI 271
            + T I +          +     +   S+SP    H  S      ++  L+ + S    
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444

Query: 272 SPGRYS-------------PIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAV-------S 311
           +P R S              I   ++ + +     Q      QP    +  +       +
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETNKEPRYQEDPPAPQPKAAPRTFLRPSPEDEA 504

Query: 312 LEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGID 371
           + G   K+V  K    +G  + GG D  GIFV+ I  G  A+  G LQ GDQIL VN  D
Sbjct: 505 IYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQD 562

Query: 372 LRGASHEQAAAALKGA--GQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLR 429
            RG   E A   L     G+ VTI+AQ + + Y                  ++ G G   
Sbjct: 563 FRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDI---------------LACGRGD-- 605

Query: 430 TNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGD 486
                S ++R+ F+ +K        Q L+F  G++  V++   D     W A R+   G+
Sbjct: 606 -----SFFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRI---GN 652

Query: 487 SEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGTKT--LRGQEDL 544
             E G+IP+K R E+    +      NA+      + D   +     G K    + +EDL
Sbjct: 653 ELEKGLIPNKSRAEQMASVQ------NAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDL 706

Query: 545 IL---------SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 595
                      +YE V  +E  + RPV++ GP+ D   + L +E PD F +     T P 
Sbjct: 707 TAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP- 762

Query: 596 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 655
                               KD    K     + N         +VR + E+ KH +LDV
Sbjct: 763 --------------------KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDV 793

Query: 656 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEY 712
           +  A+  L   Q +PI IF  P S + +  M +RL   + + ++K +D+A KL++     
Sbjct: 794 TPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHL 853

Query: 713 FTAIVQGDTLEDI-YNQCKLVIEEQSGPFIWI 743
           FTA +  ++  D  +   K  I+ Q G  +W+
Sbjct: 854 FTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)

Query: 40  EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 97
           E+ +E   +TL++ +  G G +++GG DNPH    +  I I+ ++PGG A  DG L+ ND
Sbjct: 26  ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83

Query: 98  CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
            ++ VN   + +V HS AV+ L+++G +  + V+R R +
Sbjct: 84  RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)

Query: 150 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 208
           +G G +++GG  N H   G+ SI ++ ++ GG A  DG LQ  DR++MVN   +E+V H 
Sbjct: 42  RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99

Query: 209 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 242
            AV  L+ + +V  + V +P  + +      P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)

Query: 315 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 366
           E   V L K S  G G  + GG D      GE  I +S +L GGPAD  G LQ  D+++ 
Sbjct: 30  EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87

Query: 367 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
           VNG  +    H  A   L+ +G+   I+ +
Sbjct: 88  VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 24/69 (34%), Positives = 36/69 (52%), Gaps = 8/69 (11%)

Query: 146 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205
           FK    +G  +AGG        D  I+V  I +G +A+++G LQ GD++L VN      +
Sbjct: 515 FKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGL 566

Query: 206 THEEAVAIL 214
             E+AV  L
Sbjct: 567 VREDAVLYL 575



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)

Query: 48  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
           +  ++G+S +G  +AGG       +D GIF+  I  G +A ++G L+  D IL+VN  D 
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563

Query: 108 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 141
             +    AV  L E   G +V +  + R  +   ++
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 16/57 (28%), Positives = 31/57 (54%)

Query: 76  IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
           IF+ ++   G A +DG L   D IL++N      +S + A + ++++   ++L V R
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383


>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
          Length = 1668

 Score =  133 bits (334), Expect = 7e-31
 Identities = 128/476 (26%), Positives = 195/476 (40%), Gaps = 99/476 (20%)

Query: 287 DDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 346
           D    +S H     +PSM L            V   KG + +G  + GG D  GIFV+ +
Sbjct: 405 DGVLPNSTHEDGILRPSMKL------------VKFRKGDS-VGLRLAGGND-VGIFVAGV 450

Query: 347 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPEDYAR 404
           L   PA   G L+ GDQIL VN +D      E+A   L     G+ VTI+AQ + + Y R
Sbjct: 451 LEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRR 509

Query: 405 F-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
             E+ + D                       S Y+R  F+Y+K         GLSF  G+
Sbjct: 510 IVESDVGD-----------------------SFYIRTHFEYEKESP-----YGLSFNKGE 541

Query: 464 ILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVID 520
           +  V++   +     W A R+       E G+IP+K R E+     L +V++        
Sbjct: 542 VFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ-----LASVQYTLPKTAGG 596

Query: 521 SKGDIPGLGDDGYGTKTLR-GQEDLIL--------SYEPVTRQEINYTRPVIILGPMKDR 571
            + D           + LR  +EDL          +YE V  +E  + RPV I GP+ D 
Sbjct: 597 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV 656

Query: 572 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYND 631
             + L  E PD +           RD   D R    +                       
Sbjct: 657 AREKLAREEPDIY----QIAKSEPRDAGTDQRSSGII----------------------- 689

Query: 632 NLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLT 691
                 + +++ + ++ KH +LDV+ NA+ RL  AQ YPI +F+ P S + +  M  RL 
Sbjct: 690 -----RLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLC 744

Query: 692 EE---QAKKTYDRAIKLEQEFGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 743
            E    A+K Y+R+ KL +     FT  +  +++ D  Y   K  I++Q    +W+
Sbjct: 745 PESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)

Query: 43  YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 100
           +E   +TL R    G G +I+GG DNPH    +  I I+ ++ GG A  +G+L+ ND + 
Sbjct: 19  WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76

Query: 101 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
            VN V +  V H+ AV+ L+++G   ++ +RR++ +
Sbjct: 77  MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 61/249 (24%), Positives = 104/249 (41%), Gaps = 23/249 (9%)

Query: 151 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 209
           G G +I+GG  N H   G+ SI ++ ++ GG A+  G+LQ  DR+ MVN  S++ V H  
Sbjct: 33  GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90

Query: 210 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 269
           AV  L+ + +   + + +   + +  P   PD       P+       +N    Y   + 
Sbjct: 91  AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD-----PEPV------SDNEEDSYDEEIH 137

Query: 270 PISPGRYSPIPK--HMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 327
               GR   + +    +   D ++  + S + R    ++  A S   +P KV L K    
Sbjct: 138 DPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV--ASSQPAKPTKVTLVKSRKN 195

Query: 328 LGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
             +   G      IFV  I     A   G +Q GD +L +NG      S   A   ++ +
Sbjct: 196 EEY---GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERS 252

Query: 388 GQTVTIIAQ 396
              + ++ Q
Sbjct: 253 KGKLKMVVQ 261



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)

Query: 52  RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 111
           R    +G  +AGG       +D GIF+  ++    AA++G L   D ILRVN VD + + 
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479

Query: 112 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 142
             +AV  L +   G  V +  ++++ +   +VE
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)

Query: 136 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
           IL   +++  F+    +G  +AGG        D  I+V  +++   A K+G L+ GD++L
Sbjct: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468

Query: 196 MVNNYSLEEVTHEEAVAIL 214
            VNN     +  EEAV  L
Sbjct: 469 RVNNVDFTNIIREEAVLFL 487



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 14/57 (24%), Positives = 30/57 (52%)

Query: 76  IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
           IF+ +I     AA DG ++  D +L++N      +S + A   ++ +   +++ V+R
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR 262


>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
          Length = 1748

 Score =  133 bits (334), Expect = 7e-31
 Identities = 128/476 (26%), Positives = 195/476 (40%), Gaps = 99/476 (20%)

Query: 287 DDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 346
           D    +S H     +PSM L            V   KG + +G  + GG D  GIFV+ +
Sbjct: 405 DGVLPNSTHEDGILRPSMKL------------VKFRKGDS-VGLRLAGGND-VGIFVAGV 450

Query: 347 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPEDYAR 404
           L   PA   G L+ GDQIL VN +D      E+A   L     G+ VTI+AQ + + Y R
Sbjct: 451 LEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRR 509

Query: 405 F-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
             E+ + D                       S Y+R  F+Y+K         GLSF  G+
Sbjct: 510 IVESDVGD-----------------------SFYIRTHFEYEKESP-----YGLSFNKGE 541

Query: 464 ILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVID 520
           +  V++   +     W A R+       E G+IP+K R E+     L +V++        
Sbjct: 542 VFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQ-----LASVQYTLPKTAGG 596

Query: 521 SKGDIPGLGDDGYGTKTLR-GQEDLIL--------SYEPVTRQEINYTRPVIILGPMKDR 571
            + D           + LR  +EDL          +YE V  +E  + RPV I GP+ D 
Sbjct: 597 DRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADV 656

Query: 572 INDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYND 631
             + L  E PD +           RD   D R    +                       
Sbjct: 657 AREKLAREEPDIY----QIAKSEPRDAGTDQRSSGII----------------------- 689

Query: 632 NLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLT 691
                 + +++ + ++ KH +LDV+ NA+ RL  AQ YPI +F+ P S + +  M  RL 
Sbjct: 690 -----RLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLC 744

Query: 692 EE---QAKKTYDRAIKLEQEFGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 743
            E    A+K Y+R+ KL +     FT  +  +++ D  Y   K  I++Q    +W+
Sbjct: 745 PESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)

Query: 43  YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 100
           +E   +TL R    G G +I+GG DNPH    +  I I+ ++ GG A  +G+L+ ND + 
Sbjct: 19  WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76

Query: 101 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 136
            VN V +  V H+ AV+ L+++G   ++ +RR++ +
Sbjct: 77  MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 61/249 (24%), Positives = 104/249 (41%), Gaps = 23/249 (9%)

Query: 151 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 209
           G G +I+GG  N H   G+ SI ++ ++ GG A+  G+LQ  DR+ MVN  S++ V H  
Sbjct: 33  GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90

Query: 210 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 269
           AV  L+ + +   + + +   + +  P   PD       P+       +N    Y   + 
Sbjct: 91  AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD-----PEPV------SDNEEDSYDEEIH 137

Query: 270 PISPGRYSPIPK--HMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 327
               GR   + +    +   D ++  + S + R    ++  A S   +P KV L K    
Sbjct: 138 DPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSV--ASSQPAKPTKVTLVKSRKN 195

Query: 328 LGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
             +   G      IFV  I     A   G +Q GD +L +NG      S   A   ++ +
Sbjct: 196 EEY---GLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERS 252

Query: 388 GQTVTIIAQ 396
              + ++ Q
Sbjct: 253 KGKLKMVVQ 261



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)

Query: 52  RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 111
           R    +G  +AGG       +D GIF+  ++    AA++G L   D ILRVN VD + + 
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479

Query: 112 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 142
             +AV  L +   G  V +  ++++ +   +VE
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)

Query: 136 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
           IL   +++  F+    +G  +AGG        D  I+V  +++   A K+G L+ GD++L
Sbjct: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468

Query: 196 MVNNYSLEEVTHEEAVAIL 214
            VNN     +  EEAV  L
Sbjct: 469 RVNNVDFTNIIREEAVLFL 487



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 14/57 (24%), Positives = 30/57 (52%)

Query: 76  IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
           IF+ +I     AA DG ++  D +L++N      +S + A   ++ +   +++ V+R
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQR 262


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score =  132 bits (331), Expect = 2e-30
 Identities = 108/351 (30%), Positives = 156/351 (44%), Gaps = 49/351 (13%)

Query: 48   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
            I + +G SGLG SI GG D P       I I ++   GAAA DGRL   D IL VN VD+
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493

Query: 108  SEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLF------KGPKGLGFSIAGGVG 161
               SH +A+ AL++    VRL V R          +++F      K  +GLG SI G   
Sbjct: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK-- 1551

Query: 162  NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVV 221
                   + ++++ I+ GGAA  DGRL  GD++L VN   +   + E    ILK    +V
Sbjct: 1552 ----RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607

Query: 222  YLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK 281
             L++G+      T          S     +N   S  +       S  P+  G       
Sbjct: 1608 QLEIGRLRAGSWT----------SARTTSQNSQGSQQSAHSSCHPSFAPVITG------- 1650

Query: 282  HMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKG-STGLGFNIVGGEDGE- 339
                        Q+   T++ S   Q+    + EPR V +++  S  LG +I GG     
Sbjct: 1651 -----------LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL 1699

Query: 340  ---GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
                +F++ I A G A  + +L+ GD+I+S+NG  L G SH      LK A
Sbjct: 1700 GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750



 Score =  122 bits (306), Expect = 1e-27
 Identities = 105/404 (25%), Positives = 174/404 (43%), Gaps = 71/404 (17%)

Query: 46  EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105
           EE+ L    SGLGF I GG  +       G+ +  I+PGG A  DGRL+  D IL++   
Sbjct: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299

Query: 106 DVSEVSHSKAVEALKEAGSIVRLYVRRR-------RPILETVVEIKL----FKGP----- 149
           +V  ++  +  + L+  G+ VR+ V R         P     + + L     KGP     
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359

Query: 150 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
                         + LG  I G VG  H    + IYV  II G AA  +G +QV D+++
Sbjct: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419

Query: 196 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 255
            V+  +++   + + V +L+N  +VV+L + +  T   T P  PP    +   P++   L
Sbjct: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479

Query: 256 SGNNGTLEYKTSLPPISPGRYSPIPKHM--LVDDDYTSHSQHSTATRQPS---------- 303
               G +E +T++     G    I + +  L +D+  +  +       P           
Sbjct: 480 F-LTGAVETETNV----DGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENL 534

Query: 304 ---------MTLQRAVSLEGEPRK----VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGG 350
                     TL   ++ + E +K    + +H    G+  +   G      ++S I++GG
Sbjct: 535 LGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGG 590

Query: 351 PADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394
           P D  G LQ  D++L VNG+ L G S  +A + LK      T++
Sbjct: 591 PVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634



 Score =  107 bits (266), Expect = 5e-23
 Identities = 104/384 (27%), Positives = 166/384 (43%), Gaps = 97/384 (25%)

Query: 38  GTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 96
           G +IEY    I +ER ++G LGFS+     + ++G    IF+  + PG  A  D RL+ N
Sbjct: 129 GRQIEY----IDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKEN 182

Query: 97  DCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRRR--------------RPILETVV 141
           D IL +N   + + +SH +A+  L++    +RL V R                 + ETV 
Sbjct: 183 DQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC 242

Query: 142 -----EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 196
                E++L     GLGF I GG         + + V  I+ GG A +DGRLQ GD +L 
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILK 295

Query: 197 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 256
           +   +++ +T E+   +L+N    V + V +       DP G   +T    PP    L  
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR-------DPAGDISVT----PPAPAAL-- 342

Query: 257 GNNGTLEYKTSLPPIS---PGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLE 313
                     +LP ++   PG  S + +   V+                           
Sbjct: 343 --------PVALPTVASKGPGSDSSLFETYNVE--------------------------- 367

Query: 314 GEPRKVVLHKGSTGLGFNIVG----GEDGE--GIFVSFILAGGPADLSGELQRGDQILSV 367
                 ++ K    LG  IVG       GE  GI+V  I+ G  A  +G +Q  D+I++V
Sbjct: 368 ------LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAV 421

Query: 368 NGIDLRGASHEQAAAALKGAGQTV 391
           +G++++G ++      L+ AGQ V
Sbjct: 422 DGVNIQGFANHDVVEVLRNAGQVV 445



 Score =  100 bits (249), Expect = 5e-21
 Identities = 112/405 (27%), Positives = 159/405 (39%), Gaps = 98/405 (24%)

Query: 44   EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
            E   I LE+  +GLG S+AG  D   +     IF+  I P G AA DGR+R+ D +L +N
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMS----IFVVGINPEGPAAADGRMRIGDELLEIN 1291

Query: 104  EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ 163
               +   SH  A   +K A S V+L   R    +  +  +  F  P     SI    G +
Sbjct: 1292 NQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQSGTE 1350

Query: 164  HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 223
             I               ++++DG ++VG + L       E  + + AV+ +K        
Sbjct: 1351 PI---------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQK----- 1384

Query: 224  KVGKPTTIYMTD---PYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPI- 279
                PT +  +    P  P    HS       +   G    L    +  PI PG+   I 
Sbjct: 1385 ---YPTKVSFSSQEIPLAPASSYHSTDADFTGY--GGFQAPLSVDPATCPIVPGQEMIIE 1439

Query: 280  ------------------PKHMLV----------------------------DDDYTSHS 293
                              P + +V                            D   +SH 
Sbjct: 1440 ISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHE 1499

Query: 294  QHSTATRQPSMTLQRAV-----------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 342
            +  TA RQ    ++  V           +LE  P   +  K   GLG +IVG  +G G+F
Sbjct: 1500 EAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVD-LQKKAGRGLGLSIVGKRNGSGVF 1558

Query: 343  VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
            +S I+ GG ADL G L +GDQILSVNG D+R AS E  A  LK A
Sbjct: 1559 ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 83/298 (27%), Positives = 132/298 (44%), Gaps = 39/298 (13%)

Query: 143  IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
            I+L K   GLG S+AG      +    SI+V  I   G A  DGR+++GD LL +NN  L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295

Query: 203  EEVTHEEAVAILKNTS---EVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENH--LLSG 257
               +H+ A AI+K      ++V+++           P+  P  + S          + S 
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355

Query: 258  NNGTLE-----------YKTSLPPISPGRY-------------SPIPKHMLVDDDYTSHS 293
             +G++E           +K ++  +   +Y             +P   +   D D+T + 
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415

Query: 294  QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG--EGIFVSFILAGGP 351
                       T      + G+   + + KG +GLG +IVGG+D     I +  +   G 
Sbjct: 1416 GFQAPLSVDPATCP---IVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGA 1472

Query: 352  ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKI 409
            A   G L  GDQIL VNG+DLR +SHE+A  AL+   Q V ++  Y+ E + R E  +
Sbjct: 1473 AARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENL 1529



 Score = 90.9 bits (224), Expect = 4e-18
 Identities = 70/262 (26%), Positives = 112/262 (42%), Gaps = 23/262 (8%)

Query: 143  IKLFKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194
            +++F+ P   LG SI GG          + + G   I++ ++++   A K   L+ GD++
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125

Query: 195  LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHL 254
            L V+   L+  +H EAV  +KN         G P    +      P +  +         
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKN--------AGNPVVFIVQSLSSTPRVIPNVHNKANKIT 1177

Query: 255  LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEG 314
             + N  T E K      +P      P +  + DD   + +    T Q     QR   L G
Sbjct: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQ--KIRQRYADLPG 1235

Query: 315  EPRKVVLHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGIDL 372
            E   + L K   GLG ++ G +D     IFV  I   GPA   G ++ GD++L +N   L
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295

Query: 373  RGASHEQAAAALKGAGQTVTII 394
             G SH+ A+A +K A   V ++
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLV 1317



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 66/250 (26%), Positives = 107/250 (42%), Gaps = 66/250 (26%)

Query: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE-VTHEE 209
           GLGFS+   + +Q++ G   I+V  +  G  A +D RL+  D++L +N+  L++ ++H++
Sbjct: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201

Query: 210 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLP 269
           A+A                                         LL    G+L    +  
Sbjct: 202 AIA-----------------------------------------LLQQTTGSLRLIVARE 220

Query: 270 PISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLG 329
           P+                    H++ ST++     TL   V   G   +V L    +GLG
Sbjct: 221 PV--------------------HTKSSTSSSLNDTTLPETVCW-GHVEEVELINDGSGLG 259

Query: 330 FNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ 389
           F IVGG+   G+ V  I+ GG AD  G LQ GD IL + G +++G + EQ A  L+  G 
Sbjct: 260 FGIVGGKTS-GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGN 318

Query: 390 TVTIIAQYQP 399
           +V ++    P
Sbjct: 319 SVRMLVARDP 328



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 76/276 (27%), Positives = 113/276 (40%), Gaps = 72/276 (26%)

Query: 17   DTIASLKQCEQAMQHAFIPVNGTEIEYEFEE------ITLER-GNSGLGFSIAGGTDNPH 69
            + I +L+Q  Q ++   + V   E  Y  EE      + L++    GLG SI G  +   
Sbjct: 1500 EAITALRQTPQKVR---LVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGS- 1555

Query: 70   IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLY 129
                 G+FI+ I+ GGAA  DGRL   D IL VN  D+   S       LK A  +V+L 
Sbjct: 1556 -----GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLE 1610

Query: 130  VRRRR------------------------------PI---LETVVEIKLFKGPK------ 150
            + R R                              P+   L+ +V  K    P       
Sbjct: 1611 IGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGT 1670

Query: 151  ---------------GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
                            LG SIAGG G+    GD  +++  I   G A +  +L+VGDR++
Sbjct: 1671 DMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIV 1728

Query: 196  MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 231
             +N   L+ ++H + V +LKN    + L+V   T I
Sbjct: 1729 SINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 101/448 (22%), Positives = 171/448 (38%), Gaps = 88/448 (19%)

Query: 50  LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 109
           + +    LG  I G     H G+  GI++  IIPG AA  +G ++VND I+ V+ V++  
Sbjct: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQG 428

Query: 110 VSHSKAVEALKEAGSIVRLYVRRRR---------PILETVVEIKLFKGPKGLGFSIAGGV 160
            ++   VE L+ AG +V L + RR+         P  +    ++  K P      + G V
Sbjct: 429 FANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPP---ALFLTGAV 485

Query: 161 GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL-----------------LMVNNYSLE 203
             +         + + ID     K+  +Q  ++L                 L+  +Y + 
Sbjct: 486 ETETNVDGEDEEIKERID---TLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVM 542

Query: 204 EVTHEEAVAI---LKNTSEVV---YLKVGKPTTIYMTDPY-------GPPDITHSYSPPM 250
             T +  +A    L+  S+++    L++G     +    Y       GP D      P  
Sbjct: 543 VATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQP-- 600

Query: 251 ENHLLSGNNGTLEYKTSLPPIS-----PGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMT 305
           E+ LL  N   L  K+    +S     P  ++ +    L DD+ +      T T  P   
Sbjct: 601 EDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETE 660

Query: 306 LQRAVSLEGEP-------------RKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFIL 347
           +   + +  E              + V L K   GLGF+I+  +D        I +  ++
Sbjct: 661 VDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLV 720

Query: 348 AGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA------------------GQ 389
           A G A+ SG L  GD+++SVN   L   S  +A   LK                     +
Sbjct: 721 ADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEE 780

Query: 390 TVTIIAQYQPEDYARFEAKIHDLREQMM 417
           +  I+     ED   F   IHD+   ++
Sbjct: 781 SCYILHSSSNEDKTEFSGTIHDINSSLI 808



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 11/94 (11%)

Query: 314  GEPRKV-VLHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELQRGD 362
            G PR V +  + +  LG +IVGG          E+ +GIF+  +L   PA  +  L+ GD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123

Query: 363  QILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
            +IL V+G+DL+ ASH +A  A+K AG  V  I Q
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 4/82 (4%)

Query: 54   NSGLGFSIAGGTD---NPHIGDD-PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 109
            N  LG SI GG         G++  GIFI +++    A +   L+  D IL V+ VD+  
Sbjct: 1076 NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQN 1135

Query: 110  VSHSKAVEALKEAGSIVRLYVR 131
             SHS+AVEA+K AG+ V   V+
Sbjct: 1136 ASHSEAVEAIKNAGNPVVFIVQ 1157



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 1/77 (1%)

Query: 44  EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
           E + + L +   GLGFSI    D P       I I  ++  G A   G L   D ++ VN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741

Query: 104 EVDVSEVSHSKAVEALK 120
           E  +   S ++AVE LK
Sbjct: 742 EYCLDNTSLAEAVEILK 758


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score =  122 bits (306), Expect = 1e-27
 Identities = 115/400 (28%), Positives = 172/400 (43%), Gaps = 92/400 (23%)

Query: 27   QAMQHAFIPVNGTEIEYEFEEI----TLE---RGNSGLGFSIAGGTDNPHIGDDPGIFIT 79
            Q  Q   + +   E  Y+ EE+    T+E   +   GLG SI G  +      D G+F++
Sbjct: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN------DTGVFVS 1752

Query: 80   KIIPGGAAAEDGRLRVNDCILRVNEVDV--------------SEVSHSKAVEALKEAGSI 125
             I+ GG A  DGRL   D IL VN  DV              SE S S     L  + + 
Sbjct: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS 1812

Query: 126  VRLYVRRRRPILETVVE----IKLFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180
              L    ++  L + ++    +++ KGP   LG SIAGGVG+    GD  I++  +   G
Sbjct: 1813 ESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL--GDVPIFIAMMHPTG 1870

Query: 181  AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPP 240
             A +  +L+VGDR++ +   S E +TH +AV +LKN S  + ++V               
Sbjct: 1871 VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQV--------------- 1915

Query: 241  DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300
                         +  G+   +      P  S   ++ +    +  DD            
Sbjct: 1916 -------------VAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL----------- 1951

Query: 301  QPSMTLQRAVSLEGEP--RKVVLHKGSTGLGFNIVGGEDGE----GIFVSFILAGGPADL 354
                         G P  + + L +G  GLGF+IVGG         I+V  + A G A  
Sbjct: 1952 -------------GPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998

Query: 355  SGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394
             G L+RGDQI++VNG  L G +HE+A A LK    TVT++
Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038



 Score =  115 bits (288), Expect = 1e-25
 Identities = 80/210 (38%), Positives = 109/210 (51%), Gaps = 36/210 (17%)

Query: 48   ITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106
            + +++G    LG SIAGG  +P +GD P IFI  + P G AA+  +LRV D I+ +    
Sbjct: 1834 VEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891

Query: 107  VSEVSHSKAVEALKEAGSIVRLYV-----------RRRRPILETVV-------------- 141
               ++H++AV  LK A   + + V            ++ P   ++               
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL 1951

Query: 142  ------EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195
                   I L +GP GLGFSI GG G+ H  GD  IYV  +   GAA +DGRL+ GD+++
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQII 2009

Query: 196  MVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
             VN  SLE VTHEEAVAILK T   V L V
Sbjct: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score =  114 bits (286), Expect = 3e-25
 Identities = 100/396 (25%), Positives = 176/396 (44%), Gaps = 69/396 (17%)

Query: 46  EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105
           E I L    SGLGF I GG          G+ +  I+PGG A + GRL   D IL++ + 
Sbjct: 256 ETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308

Query: 106 DVSEVSHSKAVEALKEAGSIVRLYVRR---------------------RRPILET----- 139
           D++ +S  +  + L++ G+ V+L + R                       P L       
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368

Query: 140 ------VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDR 193
                   +++L K  +GLG +IAG +G++ +   + I+V  I    A + DGR+Q+GD+
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427

Query: 194 LLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYS-PPMEN 252
           ++ V+  +L+  T+++AV +L++T + V L + +       +     D+T      P+  
Sbjct: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487

Query: 253 HLLSGNNGTLE------YKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTL 306
            ++  N    E        T++ P     Y  +   +   +D         A +Q +  L
Sbjct: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIED---------AQKQEAALL 538

Query: 307 QRAVSLEGEPRKVVL-----HKGSTGLGFNI---VGGEDGEGIFVSFILAGGPADLSGEL 358
            +   + G   ++V+        ++GLG ++   VG       F+  +L  GP   SG+L
Sbjct: 539 TKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVLPEGPVGHSGKL 593

Query: 359 QRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394
             GD++L VNGI L G +H+     LK     VT++
Sbjct: 594 FSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629



 Score =  111 bits (277), Expect = 3e-24
 Identities = 109/388 (28%), Positives = 162/388 (41%), Gaps = 66/388 (17%)

Query: 44   EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103
            E   I LE+G+SGLG S+AG  D   +     +FI  I P GAA +DGRL++ D +L +N
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEIN 1402

Query: 104  EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-------------------------- 137
               +   SH  A   +K A S V++   R +  +                          
Sbjct: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462

Query: 138  -------ETVVEIKLFKGPKGLGF-SIAGGVGNQHIPGD--NSIYVTKIIDGGAAQKDGR 187
                   +  V++  FK  + L      GG+G      D  + + +  + + G A  DGR
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522

Query: 188  LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYS 247
            L+VGD++L V++  +     E+ +++LK     V L      TI+  +P        S +
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKL------TIHAENP-------DSQA 1569

Query: 248  PPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQ 307
             P      SG          +P       SP P+ +      TS S           T  
Sbjct: 1570 VPSAAGAASGEKKNSSQSLMVPQSG----SPEPESIR----NTSRSSTPAIFASDPATCP 1621

Query: 308  RAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG--EGIFVSFILAGGPADLSGELQRGDQIL 365
                + G    + + KG TGLG +IVGG D     I +  +   G A   G L  GDQIL
Sbjct: 1622 ---IIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678

Query: 366  SVNGIDLRGASHEQAAAALKGAGQTVTI 393
             VNGIDLR A+H++A   L+   Q V +
Sbjct: 1679 EVNGIDLRKATHDEAINVLRQTPQRVRL 1706



 Score =  109 bits (272), Expect = 1e-23
 Identities = 106/428 (24%), Positives = 175/428 (40%), Gaps = 89/428 (20%)

Query: 48   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
            I + +GNS LG +++   D        G+ +  II GGA + DGR+ + DCIL +NE   
Sbjct: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062

Query: 108  SEVSHSKAVEALK----------------------------EAGSIVRL-----YVRRRR 134
              V++++A   L+                            ++G ++ L     Y  R  
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122

Query: 135  PILETVVE---------------------IKLFKGP-KGLGFSIAGG--VGNQHIPGD-- 168
            P L    E                     ++L++ P K LG SI GG  +G++   G+  
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182

Query: 169  NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 228
              I++  +++   A K+G L+ GDR++ V+   L + +HE+AV  ++     V   V   
Sbjct: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242

Query: 229  TTIYMTDPYGPPDITHSYSP--------PMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 280
                   P   P + H+  P        P  + L    +       S P  +P    P P
Sbjct: 1243 INRPRKSPL--PSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPP 1300

Query: 281  KHMLVDDDYTSHSQHSTATRQPSMTLQ------------RAVSLEGEPRKVVLHKGSTGL 328
                  +  + H+Q S +     +  +            R  +L GE   + L KG +GL
Sbjct: 1301 PPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL 1360

Query: 329  GFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386
            G ++ G +D     +F+  I   G A   G LQ  D++L +NG  L G SH+ A++ +K 
Sbjct: 1361 GLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKC 1420

Query: 387  AGQTVTII 394
            A   V II
Sbjct: 1421 APSKVKII 1428



 Score =  100 bits (250), Expect = 4e-21
 Identities = 68/174 (39%), Positives = 94/174 (54%), Gaps = 16/174 (9%)

Query: 48   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
            I + +G +GLG SI GG+D   +G    I I ++   GAA +DGRL   D IL VN +D+
Sbjct: 1630 IEISKGRTGLGLSIVGGSDTL-LG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685

Query: 108  SEVSHSKAVEALKEAGSIVRLYVRR-RRPILETVV----EIKLFKGP-KGLGFSIAGGVG 161
             + +H +A+  L++    VRL + R   P  E  V     I+L K P KGLG SI G   
Sbjct: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743

Query: 162  NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
                  D  ++V+ I+ GG A  DGRL  GD++LMVN   +   T E   A+LK
Sbjct: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 96/375 (25%), Positives = 152/375 (40%), Gaps = 89/375 (23%)

Query: 50  LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 109
           L+  + GLGFS+ G         + GIF+ +I  G  A  DGRL+  D IL +N   + +
Sbjct: 141 LKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198

Query: 110 -VSHSKAVEALKEAGSIVRLYVRR------------RRPILETVVE-------------I 143
            ++H +A+  L++A   V+L + R            R P   + +              I
Sbjct: 199 TITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETI 258

Query: 144 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203
           +L     GLGF I GG           + V  I+ GG A + GRL  GD +L + +  L 
Sbjct: 259 ELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311

Query: 204 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE 263
            ++ E+   +L+     V L + +                                G +E
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIAR--------------------------------GAIE 339

Query: 264 YKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHK 323
            +T+  P + G                + S   T+T +  +        E E   V L K
Sbjct: 340 ERTA--PTALG---------------ITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382

Query: 324 GSTGLGFNIVG--GE---DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378
              GLG  I G  G+   +  GIFV  I      +  G +Q GDQI++V+G +L+G +++
Sbjct: 383 NVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQ 442

Query: 379 QAAAALKGAGQTVTI 393
           QA   L+  GQTV +
Sbjct: 443 QAVEVLRHTGQTVLL 457



 Score = 93.2 bits (230), Expect = 8e-19
 Identities = 85/273 (31%), Positives = 124/273 (45%), Gaps = 60/273 (21%)

Query: 143  IKLFKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
            I + KG   LG +++    G+G         + V  II GGA  +DGR+ +GD +L +N 
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059

Query: 200  YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 259
             S   VT+ +A A+L+  S +                   PDI  +Y P    HL     
Sbjct: 1060 ESTISVTNAQARAMLRRHSLI------------------GPDIKITYVPA--EHLE---- 1095

Query: 260  GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHS-----QHSTATRQPSMTLQRAVSLEG 314
               E+K SL     G+ S     + +   YT        +      + S     A S   
Sbjct: 1096 ---EFKISL-----GQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWN 1147

Query: 315  EPRKVVL-HKGSTGLGFNIVGGE-------DGE---GIFVSFILAGGPADLSGELQRGDQ 363
            +PR+V L  + S  LG +IVGG        +GE   GIF+  +L   PA  +G L+ GD+
Sbjct: 1148 QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDR 1207

Query: 364  ILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396
            I+ V+G+DLR ASHEQA  A++ AG  V  + Q
Sbjct: 1208 IVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 71/253 (28%), Positives = 106/253 (41%), Gaps = 61/253 (24%)

Query: 144 KLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
           +L K P G LGFS+ G        G+  I+V +I +G  A +DGRL+  D++L +N  +L
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196

Query: 203 EE-VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGT 261
           ++ +TH++A++IL+   + V L + + +   +  P                         
Sbjct: 197 DQTITHQQAISILQKAKDTVQLVIARGSLPQLVSP------------------------- 231

Query: 262 LEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 321
                 +   SP   S I  H         H QH                       + L
Sbjct: 232 ------IVSRSPSAASTISAH-----SNPVHWQHMET--------------------IEL 260

Query: 322 HKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAA 381
               +GLGF I+GG+   G+ V  IL GG AD  G L  GD IL +   DL G S EQ A
Sbjct: 261 VNDGSGLGFGIIGGK-ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVA 319

Query: 382 AALKGAGQTVTII 394
             L+  G  V ++
Sbjct: 320 QVLRQCGNRVKLM 332



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 111/397 (27%), Positives = 169/397 (42%), Gaps = 69/397 (17%)

Query: 42   EYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101
            E   + I LE+G+ GLGFSI    D P       I I  ++PGG A +DGRL   D ++ 
Sbjct: 695  EAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMF 753

Query: 102  VNEVDVSEVSHSKAVEALKEAGS-IVRLYVRRRRPIL--ETVVEIK-------------- 144
            VN+V++   S  +AVEALK A S  VR+ V +  P+   E  V  K              
Sbjct: 754  VNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEA 813

Query: 145  ------LFKGPKGL-GFSIAGGVG-----NQHIPGDNSIYVTK---IIDGGAAQKDGRLQ 189
                  LF+    L G + A  V      + + P ++SIY T+   +   G++  DG L 
Sbjct: 814  GLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDG-LN 872

Query: 190  VGDRL---------------LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234
             G  L               ++  + SLEE+  +  +      +  V + +G P + +  
Sbjct: 873  YGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMG-PASGFTI 931

Query: 235  DPYGPPD-ITHSYSPP-----MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDD 288
            + Y P + I   Y         E+HL S    + E    LP + P       +++L    
Sbjct: 932  NDYTPANAIEQQYECENTIVWTESHLPSEVISSAE----LPSVLPDSAGKGSEYLL---- 983

Query: 289  YTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILA 348
                 Q S A     + LQ  VS E   R + + KG++ LG  +   +DG G+ V  I+ 
Sbjct: 984  ----EQSSLACNAECVMLQN-VSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIH 1038

Query: 349  GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385
            GG     G +  GD ILS+N       ++ QA A L+
Sbjct: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 85/303 (28%), Positives = 130/303 (42%), Gaps = 61/303 (20%)

Query: 135  PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194
            P  ET +EI   KG  GLG SI GG  +  + G  +I + ++ + GAA KDGRL  GD++
Sbjct: 1624 PGCETTIEIS--KGRTGLGLSIVGG--SDTLLG--AIIIHEVYEEGAACKDGRLWAGDQI 1677

Query: 195  LMVNNYSLEEVTHEEAVAILKNTSEVVYL------------KVGKPTTIYMTDPYGP--- 239
            L VN   L + TH+EA+ +L+ T + V L            +V    TI +    G    
Sbjct: 1678 LEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLG 1737

Query: 240  --------------PDITHSYSPPMENHLLSGN-----------NGTLEYKTSLPPISPG 274
                           DI        +  L+ G+           N T E   +L  +S G
Sbjct: 1738 LSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEG 1797

Query: 275  RYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEP-RKVVLHKGST-GLGFNI 332
              S     +         S  ST+    S + + A++ E +  R V + KG T  LG +I
Sbjct: 1798 SLSSFTFPL---------SGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISI 1848

Query: 333  VGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAG 388
             GG         IF++ +   G A  + +L+ GD+I+++ G    G +H QA   LK A 
Sbjct: 1849 AGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS 1908

Query: 389  QTV 391
             ++
Sbjct: 1909 GSI 1911



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 41/85 (48%), Positives = 52/85 (61%), Gaps = 2/85 (2%)

Query: 46   EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105
            + ITLERG  GLGFSI GG  +PH GD P I++  +   GAA+EDGRL+  D I+ VN  
Sbjct: 1957 KSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2014

Query: 106  DVSEVSHSKAVEALKEAGSIVRLYV 130
             +  V+H +AV  LK     V L V
Sbjct: 2015 SLEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 67/269 (24%), Positives = 109/269 (40%), Gaps = 44/269 (16%)

Query: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
           V  +  F    GLG S+   VG+         ++  ++  G     G+L  GD LL VN 
Sbjct: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604

Query: 200 YSLEEVTHEEAVAILKN----TSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 255
            +L    H++ V ILK      + V   +   PTT    D     DI  +  P ++    
Sbjct: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEF 664

Query: 256 SGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGE 315
            G++ T +   ++                     T   Q +   + P    +  +     
Sbjct: 665 IGSSETEDPVLAM---------------------TDAGQSTEEVQAPLAMWEAGI----- 698

Query: 316 PRKVVLHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGI 370
            + + L KGS GLGF+I+  +D        I +  ++ GG A+  G L  GD+++ VN +
Sbjct: 699 -QHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757

Query: 371 DLRGASHEQAAAALKGAGQTVTIIAQYQP 399
           +L  +S E+A  ALKGA      I   +P
Sbjct: 758 NLENSSLEEAVEALKGAPSGTVRIGVAKP 786



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 60/174 (34%), Positives = 80/174 (45%), Gaps = 33/174 (18%)

Query: 65  TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS 124
           T+ PH+  D G FI     G +  ED  L + D      EV        +A  A+ EAG 
Sbjct: 654 TEKPHV--DLGEFI-----GSSETEDPVLAMTDAGQSTEEV--------QAPLAMWEAG- 697

Query: 125 IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 184
                          +  I+L KG KGLGFSI     +   P    I +  ++ GG A+K
Sbjct: 698 ---------------IQHIELEKGSKGLGFSILD-YQDPIDPASTVIIIRSLVPGGIAEK 741

Query: 185 DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTIYMTDPY 237
           DGRL  GDRL+ VN+ +LE  + EEAV  LK   S  V + V KP  +   + Y
Sbjct: 742 DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGY 795



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 67/262 (25%), Positives = 101/262 (38%), Gaps = 49/262 (18%)

Query: 143  IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202
            I+L KG  GLG S+AG      +    S+++  I   GAA KDGRLQ+ D LL +N   L
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406

Query: 203  EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTL 262
               +H+ A +I+K                               +P     +   N   +
Sbjct: 1407 YGRSHQNASSIIK------------------------------CAPSKVKIIFIRNKDAV 1436

Query: 263  EYKTSLPPISPGR-YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEG--EPRKV 319
                    + PG    P+P +        S +  +  T     T   AV L      + +
Sbjct: 1437 NQMA----VCPGNAVEPLPSN--------SENLQNKETEPTVTTSDAAVDLSSFKNVQHL 1484

Query: 320  VLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 379
             L K   GLG  I   +   G+ +  +   G A   G L+ GDQIL+V+   + G   E+
Sbjct: 1485 ELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEK 1544

Query: 380  AAAALKGAGQTVTIIAQYQPED 401
              + LK A  TV +    +  D
Sbjct: 1545 FISLLKTAKMTVKLTIHAENPD 1566



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 32/96 (33%), Positives = 50/96 (52%), Gaps = 9/96 (9%)

Query: 42  EYEFEEITLERGNSGLGFSIAGGTDNPHIGDDP----GIFITKIIPGGAAAEDGRLRVND 97
           E E  ++ L +   GLG +IAG     +IGD      GIF+  I    A   DGR+++ D
Sbjct: 372 ESETFDVELTKNVQGLGITIAG-----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426

Query: 98  CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 133
            I+ V+  ++   ++ +AVE L+  G  V L + RR
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462


>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
          Length = 637

 Score =  122 bits (305), Expect = 2e-27
 Identities = 69/216 (31%), Positives = 117/216 (54%), Gaps = 19/216 (8%)

Query: 548 YEPVTRQEINYT---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVD 601
           YE V R +   +   R ++++GP    +N+    LI   P  F S VPHTTR K+ YE++
Sbjct: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472

Query: 602 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 661
           GR+YH+V S+E  E  I  H+ +E G+Y  +LYGTSV +V+ V   GK C++D+    I+
Sbjct: 473 GREYHYV-SKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQ 531

Query: 662 RLQVAQLYPIAIFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEF 709
            ++  +L P  IFIKP ++  + +  K            +  +E  ++  + A ++E +F
Sbjct: 532 GVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQF 591

Query: 710 GEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
           G++F  ++  D+L D   Q    I++      W+P+
Sbjct: 592 GQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPA 627



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 56/190 (29%), Positives = 89/190 (46%), Gaps = 31/190 (16%)

Query: 317 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376
           R V L K    LG  I   E    I V+ I+ GG A+ SG L  GD+++ VNG+ + G  
Sbjct: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212

Query: 377 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 436
            EQ    L  +  T+                K+  + +  +N              ++ +
Sbjct: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVN-------------SQQMV 245

Query: 437 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 494
           YVRAM +Y   +D  +P    GL F+ GDIL +++ +D  WWQAR++     +   G++P
Sbjct: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPATCAGLVP 303

Query: 495 SKRRVERKER 504
           S   ++RK+R
Sbjct: 304 SNHLLKRKQR 313



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 6/81 (7%)

Query: 145 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 204
           L K  + LG +I        + GD  I V +II GG A++ G L  GD+L+ VN  S+E 
Sbjct: 157 LVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210

Query: 205 VTHEEAVAILKNTSEVVYLKV 225
           +  E+ + IL  +   +  KV
Sbjct: 211 LDPEQVIHILAMSRGTIMFKV 231


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.136    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,202,100
Number of Sequences: 37866
Number of extensions: 1398512
Number of successful extensions: 4647
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 3346
Number of HSP's gapped (non-prelim): 981
length of query: 749
length of database: 18,247,518
effective HSP length: 110
effective length of query: 639
effective length of database: 14,082,258
effective search space: 8998562862
effective search space used: 8998562862
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.