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Search of human proteins with 218156338
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
(975 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 1968 0.0
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 1723 0.0
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 1342 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 1212 0.0
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 1165 0.0
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 1004 0.0
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 969 0.0
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 963 0.0
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 739 0.0
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 628 e-180
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 214 4e-55
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 198 2e-50
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 182 2e-45
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 178 2e-44
gi|95089461 discs large homolog 5 [Homo sapiens] 172 1e-42
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 169 2e-41
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 167 3e-41
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 158 3e-38
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 156 8e-38
gi|10092691 tight junction protein 3 [Homo sapiens] 156 1e-37
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 152 1e-36
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 152 1e-36
gi|45827729 scribble isoform b [Homo sapiens] 145 2e-34
gi|45827731 scribble isoform a [Homo sapiens] 145 2e-34
gi|148746189 multiple PDZ domain protein [Homo sapiens] 139 2e-32
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 138 3e-32
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 138 3e-32
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 137 5e-32
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 137 5e-32
gi|112382257 InaD-like [Homo sapiens] 120 8e-27
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 1968 bits (5099), Expect = 0.0
Identities = 975/975 (100%), Positives = 975/975 (100%)
Query: 1 MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKS 60
MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKS
Sbjct: 1 MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKS 60
Query: 61 SELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPAQNCSVEAPAWMPVHHCTK 120
SELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPAQNCSVEAPAWMPVHHCTK
Sbjct: 61 SELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPAQNCSVEAPAWMPVHHCTK 120
Query: 121 YRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPII 180
YRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPII
Sbjct: 121 YRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPII 180
Query: 181 VNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPG 240
VNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPG
Sbjct: 181 VNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPG 240
Query: 241 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIK 300
GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIK
Sbjct: 241 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIK 300
Query: 301 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 360
LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE
Sbjct: 301 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 360
Query: 361 VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEY 420
VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEY
Sbjct: 361 VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEY 420
Query: 421 KTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLL 480
KTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLL
Sbjct: 421 KTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLL 480
Query: 481 SAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI 540
SAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI
Sbjct: 481 SAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI 540
Query: 541 VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT 600
VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT
Sbjct: 541 VGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT 600
Query: 601 IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGL 660
IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGL
Sbjct: 601 IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGL 660
Query: 661 PSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKF 720
PSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKF
Sbjct: 661 PSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKF 720
Query: 721 NAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQ 780
NAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQ
Sbjct: 721 NAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQ 780
Query: 781 EINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQM 840
EINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQM
Sbjct: 781 EINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQM 840
Query: 841 EKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIF 900
EKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIF
Sbjct: 841 EKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIF 900
Query: 901 IKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIE 960
IKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIE
Sbjct: 901 IKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIE 960
Query: 961 EQSGPFIWIPSKEKL 975
EQSGPFIWIPSKEKL
Sbjct: 961 EQSGPFIWIPSKEKL 975
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 1723 bits (4463), Expect = 0.0
Identities = 856/856 (100%), Positives = 856/856 (100%)
Query: 120 KYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI 179
KYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI
Sbjct: 15 KYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPI 74
Query: 180 IVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 239
IVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP
Sbjct: 75 IVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 134
Query: 240 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 299
GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI
Sbjct: 135 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEI 194
Query: 300 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359
KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE
Sbjct: 195 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 254
Query: 360 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE 419
EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE
Sbjct: 255 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE 314
Query: 420 YKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFL 479
YKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFL
Sbjct: 315 YKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFL 374
Query: 480 LSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFN 539
LSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFN
Sbjct: 375 LSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFN 434
Query: 540 IVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 599
IVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV
Sbjct: 435 IVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTV 494
Query: 600 TIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSG 659
TIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSG
Sbjct: 495 TIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSG 554
Query: 660 LPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVK 719
LPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVK
Sbjct: 555 LPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVK 614
Query: 720 FNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTR 779
FNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTR
Sbjct: 615 FNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTR 674
Query: 780 QEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQ 839
QEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQ
Sbjct: 675 QEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQ 734
Query: 840 MEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAI 899
MEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAI
Sbjct: 735 MEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAI 794
Query: 900 FIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVI 959
FIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVI
Sbjct: 795 FIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVI 854
Query: 960 EEQSGPFIWIPSKEKL 975
EEQSGPFIWIPSKEKL
Sbjct: 855 EEQSGPFIWIPSKEKL 870
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 1342 bits (3472), Expect = 0.0
Identities = 693/784 (88%), Positives = 698/784 (89%), Gaps = 70/784 (8%)
Query: 192 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 251
VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV
Sbjct: 36 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
Query: 252 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 311
NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS
Sbjct: 96 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
Query: 312 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 371
IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK
Sbjct: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
Query: 372 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 431
NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR
Sbjct: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
Query: 432 YSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGL 491
YSPI P+H +
Sbjct: 276 YSPI------------------------------PKH----------------------M 283
Query: 492 LPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 551
L D + TSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV
Sbjct: 284 LVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFV 343
Query: 552 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 611
SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA
Sbjct: 344 SFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYA 403
Query: 612 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 671
RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD
Sbjct: 404 RFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGD 463
Query: 672 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 731
ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG
Sbjct: 464 ILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG 523
Query: 732 SFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIIL 791
+ + RGQEDLILSYEPVTRQEINYTRPVIIL
Sbjct: 524 DIPGLGDDGY------------------GTKTLRGQEDLILSYEPVTRQEINYTRPVIIL 565
Query: 792 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 851
GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE
Sbjct: 566 GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIE 625
Query: 852 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 911
AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME
Sbjct: 626 AGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME 685
Query: 912 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 971
MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS
Sbjct: 686 MNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 745
Query: 972 KEKL 975
KEKL
Sbjct: 746 KEKL 749
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 1212 bits (3136), Expect = 0.0
Identities = 652/1023 (63%), Positives = 749/1023 (73%), Gaps = 182/1023 (17%)
Query: 1 MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKS 60
+ IF+S+LFQAL+DIQEFYEVTLL++ K C DR + S
Sbjct: 38 INIFQSNLFQALIDIQEFYEVTLLDNPK------------------------CIDRSKPS 73
Query: 61 SELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPAQNCSVEAPAWMPVHHCTK 120
+ + E S + T + T P SVE K
Sbjct: 74 EPIQPVN-----------TWEISSLPSSTVTSETLPSSLSP----SVE-----------K 107
Query: 121 YRYQDEDAP-HDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLK------ 173
YRYQDED P +H P++T+EV GPELVHVSEKNLS+IENVHG+V SHISP+K
Sbjct: 108 YRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVL 167
Query: 174 ---------------------------ASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITL 206
A+P P++VNTD+L+T YVNGT+ +YE+EEITL
Sbjct: 168 PSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITL 227
Query: 207 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 266
ERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRVNDCILRVNEVDV +V
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
Query: 267 SHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNS 326
+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFSIAGGVGNQHIPGDNS
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS 347
Query: 327 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 386
IYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LKNTS+ VYLKV KPT+
Sbjct: 348 IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407
Query: 387 IYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYT 446
+YM D Y PPDIT+S S P++NH +SP +
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNH-----------------VSPSSF-------------- 436
Query: 447 RPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTA 506
L PASP YSPV +L D E+T
Sbjct: 437 ------------LGQTPASPARYSPVS---------------KAVLGDDEITR------- 462
Query: 507 TRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL 566
EPRKVVLH+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGEL
Sbjct: 463 ----------------EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
Query: 567 QRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMN 626
++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+AQY+PE+Y+RFEAKIHDLREQMMN
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMN 566
Query: 627 HSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQA 686
S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINASDDEWWQA
Sbjct: 567 SSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQA 626
Query: 687 RRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRK 746
R+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K D SFNDKRKK+ +FSRK
Sbjct: 627 RQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR--DKGQSFNDKRKKN-LFSRK 683
Query: 747 FPFYKNKEQSEQETSDPE--------------RGQEDLILSYEPVTRQEINYTRPVIILG 792
FPFYKNK+QSEQETSD + RGQE+ +LSYEPV +QE+NYTRPVIILG
Sbjct: 684 FPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILG 743
Query: 793 PMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEA 852
PMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIEA
Sbjct: 744 PMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEA 803
Query: 853 GQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM 912
GQYN++LYGTSVQSVR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +MEM
Sbjct: 804 GQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEM 863
Query: 913 NKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSK 972
NKRLTEEQA+KT++RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+K
Sbjct: 864 NKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAK 923
Query: 973 EKL 975
EKL
Sbjct: 924 EKL 926
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 1165 bits (3015), Expect = 0.0
Identities = 628/1009 (62%), Positives = 726/1009 (71%), Gaps = 176/1009 (17%)
Query: 1 MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKS 60
+ IF+S+LFQAL+DIQEFYEVTLL++ K C DR + S
Sbjct: 38 INIFQSNLFQALIDIQEFYEVTLLDNPK------------------------CIDRSKPS 73
Query: 61 SELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPAQNCSVEAPAWMPVHHCTK 120
+ + E S + T + T P SVE K
Sbjct: 74 EPIQPVN-----------TWEISSLPSSTVTSETLPSSLSP----SVE-----------K 107
Query: 121 YRYQDEDAP-HDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLK------ 173
YRYQDED P +H P++T+EV GPELVHVSEKNLS+IENVHG+V SHISP+K
Sbjct: 108 YRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVL 167
Query: 174 ---------------------------ASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITL 206
A+P P++VNTD+L+T YVNGT+ +YE+EEITL
Sbjct: 168 PSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITL 227
Query: 207 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 266
ERGNSGLGFSIAGGTDNPHIGDD IFITKII GGAAA+DGRLRVNDCILRVNEVDV +V
Sbjct: 228 ERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDV 287
Query: 267 SHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNS 326
+HSKAVEALKEAGSIVRLYV+RR+P+ E ++EIKL KGPKGLGFSIAGGVGNQHIPGDNS
Sbjct: 288 THSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS 347
Query: 327 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 386
IYVTKII+GGAA KDG+LQ+GD+LL VNN LEEVTHEEAV LKNTS+ VYLKV KPT+
Sbjct: 348 IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407
Query: 387 IYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYT 446
+YM D Y PPDIT+S S P++NH +SP +
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNH-----------------VSPSSF-------------- 436
Query: 447 RPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTA 506
L PASP YSPV +L D E+T
Sbjct: 437 ------------LGQTPASPARYSPVS---------------KAVLGDDEITR------- 462
Query: 507 TRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL 566
EPRKVVLH+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGEL
Sbjct: 463 ----------------EPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGEL 506
Query: 567 QRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMN 626
++GD+I+SVN +DLR ASHEQAAAALK AGQ VTI+AQY+PE+Y+RFEAKIHDLREQMMN
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMN 566
Query: 627 HSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQA 686
S+SSGSGSLRT+QKRSLYVRA+FDYDK+KDSGLPSQGL+FK+GDILHVINASDDEWWQA
Sbjct: 567 SSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQA 626
Query: 687 RRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRK 746
R+V +G+S+E+GVIPSKRRVE+KERARLKTVKFN+K KG D +
Sbjct: 627 RQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTR---DKGEIPDDMGSKGL---- 679
Query: 747 FPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEF 806
K+ + ++ RGQE+ +LSYEPV +QE+NYTRPVIILGPMKDRINDDLISEF
Sbjct: 680 ----KHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEF 735
Query: 807 PDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQS 866
PDKFGSCVPHTTRPKRDYEVDGRDYHFV SREQMEKDIQEHKFIEAGQYN++LYGTSVQS
Sbjct: 736 PDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQS 795
Query: 867 VRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYD 926
VR VAE+GKHCILDVSGNAIKRLQ+AQLYPI+IFIKP+S+E +MEMNKRLTEEQA+KT++
Sbjct: 796 VREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFE 855
Query: 927 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 975
RA+KLEQEF E+FTAIVQGDTLEDIYNQ K +IEEQSG +IW+P+KEKL
Sbjct: 856 RAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 1004 bits (2596), Expect = 0.0
Identities = 519/793 (65%), Positives = 611/793 (77%), Gaps = 94/793 (11%)
Query: 187 DTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED 246
D VNG++ +++EEI LERGNSGLGFSIAGG DNPH+ DDPGIFITKIIPGGAAA D
Sbjct: 115 DWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMD 174
Query: 247 GRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPK 306
GRL VNDC+LRVNEVDVSEV HS+AVEALKEAG +VRL VRRR+P ET++E+ L KGPK
Sbjct: 175 GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPK 234
Query: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366
GLGFSIAGG+GNQHIPGDNSIY+TKII+GGAAQKDGRLQ+GDRLL VNN +L++V HEEA
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294
Query: 367 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN----GTLEYKT 422
VA LKNTS++VYLKV KP ++++ D Y PPD +++ +NH+ ++ G +E K
Sbjct: 295 VASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKV 354
Query: 423 SLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSA 482
S Y PP+ P YSP+
Sbjct: 355 S---------------------YPAPPQ-------------VPPTRYSPIPRH------- 373
Query: 483 PYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVG 542
+L + + T EPRK++LHKGSTGLGFNIVG
Sbjct: 374 --------MLAEEDFTR-----------------------EPRKIILHKGSTGLGFNIVG 402
Query: 543 GEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602
GEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR A+HEQAAAALK AGQ+VTI+
Sbjct: 403 GEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462
Query: 603 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 662
AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KRSLYVRA+FDYD+++DS LPS
Sbjct: 463 AQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPS 522
Query: 663 QGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNA 722
QGLSF YGDILHVINASDDEWWQAR V G+SE++GVIPSK+RVE+KERARLKTVKF+A
Sbjct: 523 QGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA 582
Query: 723 KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEI 782
+ G+I+S +R FP + + +GQED ILSYEPVTRQEI
Sbjct: 583 RTGMIES--------------NRDFPGLSDDYYGAKNL----KGQEDAILSYEPVTRQEI 624
Query: 783 NYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEK 842
+Y RPVIILGPMKDR+NDDLISEFP KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEK
Sbjct: 625 HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEK 684
Query: 843 DIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIK 902
DIQ++KFIEAGQ+NDNLYGTS+QSVR VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIK
Sbjct: 685 DIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 744
Query: 903 PRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQ 962
P+S+E LMEMN+R T EQA K YD+A+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+Q
Sbjct: 745 PKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQ 804
Query: 963 SGPFIWIPSKEKL 975
SG +IW+PS EKL
Sbjct: 805 SGHYIWVPSPEKL 817
Score = 70.9 bits (172), Expect = 6e-12
Identities = 57/192 (29%), Positives = 89/192 (46%), Gaps = 22/192 (11%)
Query: 148 HVSEKN----LSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEE 203
H+S + L +E+ Y + P + SP P + + + E +
Sbjct: 337 HISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEE----------DFTREPRK 386
Query: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
I L +G++GLGF+I GG D GIF++ I+ GG A G LR D IL VN V++
Sbjct: 387 IILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVNL 440
Query: 264 SEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIP 322
+H +A ALK AG V + V + RP + E K+ + + S++ G G+
Sbjct: 441 RNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTS 499
Query: 323 GDNSIYVTKIID 334
S+YV + D
Sbjct: 500 EKRSLYVRALFD 511
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 969 bits (2504), Expect = 0.0
Identities = 507/857 (59%), Positives = 606/857 (70%), Gaps = 147/857 (17%)
Query: 120 KYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAP 178
KYRYQDED P +HS L ++ P P
Sbjct: 11 KYRYQDEDTPPLEHSPAHLPNQANSP---------------------------------P 37
Query: 179 IIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKII 238
+IVNTDTL+ YVNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFITKII
Sbjct: 38 VIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKII 97
Query: 239 PGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVE 298
PGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P E V+E
Sbjct: 98 PGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVME 157
Query: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
IKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+ L
Sbjct: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217
Query: 359 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTL 418
E+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N + +
Sbjct: 218 EDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT 277
Query: 419 EYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF 478
+Y T++ P SPR YSPV D
Sbjct: 278 DYPTAMTP-------------------------------------TSPRRYSPVAKD--- 297
Query: 479 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF 538
LL + ++ EPR++V+H+GSTGLGF
Sbjct: 298 ------------LLGEEDIPR-----------------------EPRRIVIHRGSTGLGF 322
Query: 539 NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 598
NIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK AGQT
Sbjct: 323 NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT 382
Query: 599 VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDS 658
VTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA+FDYDK+KD
Sbjct: 383 VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDC 442
Query: 659 GLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTV 718
G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVER+E +RLK
Sbjct: 443 GFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAK 502
Query: 719 KFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVT 778
+ + G +G+ED +LSYE VT
Sbjct: 503 DWGSSSG--------------------------------------SQGREDSVLSYETVT 524
Query: 779 RQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 838
+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV SRE
Sbjct: 525 QMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSRE 584
Query: 839 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 898
+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA++RLQ A L+PIA
Sbjct: 585 KMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 644
Query: 899 IFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLV 958
IFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD+ E+IY++ K V
Sbjct: 645 IFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRV 704
Query: 959 IEEQSGPFIWIPSKEKL 975
IE+ SGP+IW+P++E+L
Sbjct: 705 IEDLSGPYIWVPARERL 721
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 963 bits (2490), Expect = 0.0
Identities = 507/860 (58%), Positives = 606/860 (70%), Gaps = 150/860 (17%)
Query: 120 KYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAP 178
KYRYQDED P +HS L ++ P P
Sbjct: 54 KYRYQDEDTPPLEHSPAHLPNQANSP---------------------------------P 80
Query: 179 IIVNTDTLDTIPY---VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 235
+IVNTDTL+ Y VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFIT
Sbjct: 81 VIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFIT 140
Query: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILET 295
KIIPGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P E
Sbjct: 141 KIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEK 200
Query: 296 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355
V+EIKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+
Sbjct: 201 VMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 260
Query: 356 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 415
LE+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N + +
Sbjct: 261 VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSY 320
Query: 416 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECD 475
+Y T++ P SPR YSPV D
Sbjct: 321 LGTDYPTAMTP-------------------------------------TSPRRYSPVAKD 343
Query: 476 KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG 535
LL + ++ EPR++V+H+GSTG
Sbjct: 344 ---------------LLGEEDIPR-----------------------EPRRIVIHRGSTG 365
Query: 536 LGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
LGFNIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK A
Sbjct: 366 LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA 425
Query: 596 GQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKS 655
GQTVTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA+FDYDK+
Sbjct: 426 GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKT 485
Query: 656 KDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARL 715
KD G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVER+E +RL
Sbjct: 486 KDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL 545
Query: 716 KTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYE 775
K + + G +G+ED +LSYE
Sbjct: 546 KAKDWGSSSG--------------------------------------SQGREDSVLSYE 567
Query: 776 PVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVI 835
VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV
Sbjct: 568 TVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVS 627
Query: 836 SREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLY 895
SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA++RLQ A L+
Sbjct: 628 SREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLH 687
Query: 896 PIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQC 955
PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD+ E+IY++
Sbjct: 688 PIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKV 747
Query: 956 KLVIEEQSGPFIWIPSKEKL 975
K VIE+ SGP+IW+P++E+L
Sbjct: 748 KRVIEDLSGPYIWVPARERL 767
Score = 33.5 bits (75), Expect = 1.00
Identities = 15/26 (57%), Positives = 19/26 (73%)
Query: 3 IFKSSLFQALLDIQEFYEVTLLNSQK 28
+ S LFQALLDI ++YE +L SQK
Sbjct: 29 VLHSDLFQALLDILDYYEASLSESQK 54
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 739 bits (1907), Expect = 0.0
Identities = 366/467 (78%), Positives = 417/467 (89%), Gaps = 14/467 (2%)
Query: 523 EPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRG 582
EPRK++LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL+RGD+ILSVNG++LR
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105
Query: 583 ASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKR 642
A+HEQAAAALK AGQ+VTI+AQY+PE+Y+RFE+KIHDLREQMMN SMSSGSGSLRT++KR
Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKR 165
Query: 643 SLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 702
SLYVRA+FDYD+++DS LPSQGLSF YGDILHVINASDDEWWQAR V G+SE++GVIP
Sbjct: 166 SLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIP 225
Query: 703 SKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQE--- 759
SK+RVE+KERARLKTVKF+A+ G+I+S S KRKKSF SRKFPFYK+KE QE
Sbjct: 226 SKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSI 285
Query: 760 --------TSDPE---RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPD 808
TSD E +GQED ILSYEPVTRQEI+Y RPVIILGPMKDR+NDDLISEFP
Sbjct: 286 QEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPH 345
Query: 809 KFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVR 868
KFGSCVPHTTRP+RD EVDG+DYHFV+SREQMEKDIQ++KFIEAGQ+NDNLYGTS+QSVR
Sbjct: 346 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 405
Query: 869 FVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRA 928
VAERGKHCILDVSGNAIKRLQ AQLYPIAIFIKP+S+E LMEMN+R T EQA K YD+A
Sbjct: 406 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKA 465
Query: 929 IKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 975
+KLEQEFGEYFTAIVQGD+LE+IYN+ K +IE+QSG +IW+PS EKL
Sbjct: 466 MKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512
Score = 68.6 bits (166), Expect = 3e-11
Identities = 48/136 (35%), Positives = 71/136 (52%), Gaps = 8/136 (5%)
Query: 200 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
E +I L +G++GLGF+I GG D GIF++ I+ GG A G LR D IL VN
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVN 99
Query: 260 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFK-GPKGLGFSIAGGVGN 318
V++ +H +A ALK AG V + V + RP + E K+ + + S++ G G+
Sbjct: 100 GVNLRNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS 158
Query: 319 QHIPGDNSIYVTKIID 334
S+YV + D
Sbjct: 159 LRTSEKRSLYVRALFD 174
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 12/122 (9%)
Query: 298 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 357
+I L KG GLGF+I GG + I+V+ I+ GG A G L+ GDR+L VN +
Sbjct: 49 KIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVNGVN 102
Query: 358 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGP-PDITHSYSPPMENHLLSGNNG 416
L THE+A A LK + V + Y + Y H M N +S +G
Sbjct: 103 LRNATHEQAAAALKRAGQSVTI-----VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSG 157
Query: 417 TL 418
+L
Sbjct: 158 SL 159
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 628 bits (1619), Expect = e-180
Identities = 319/352 (90%), Positives = 321/352 (91%), Gaps = 18/352 (5%)
Query: 624 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 683
MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW
Sbjct: 1 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60
Query: 684 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIF 743
WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKG +
Sbjct: 61 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY-- 118
Query: 744 SRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLI 803
+ RGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLI
Sbjct: 119 ----------------GTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLI 162
Query: 804 SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS 863
SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS
Sbjct: 163 SEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTS 222
Query: 864 VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKK 923
VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKK
Sbjct: 223 VQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKK 282
Query: 924 TYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 975
TYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Sbjct: 283 TYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 214 bits (544), Expect = 4e-55
Identities = 156/467 (33%), Positives = 231/467 (49%), Gaps = 63/467 (13%)
Query: 522 GEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLR 581
GE K+V + + + + + + +S I+ GG A+ SG L GD++L +NGI++R
Sbjct: 251 GETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIR 310
Query: 582 GASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTN 639
G + L T+T +I Q + E IH
Sbjct: 311 GKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIH--------------------- 349
Query: 640 QKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEE 697
V+A FDYD S D +P + GLSF+ GDILHVI+ D WWQA R E +
Sbjct: 350 ------VKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPL 403
Query: 698 MGVIPSKRRVERKERARLKTVKFNAKP---GVIDSKGSFNDKRKKSFIFSRKFPFYKNKE 754
G++P K +++E A +T++ + +P G + KRKK + K Y N+E
Sbjct: 404 AGLVPGKSFQQQRE-AMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEE 462
Query: 755 QSEQETSDPERGQEDLILSYEPVT--RQEINYTRPVIILGPM---KDRINDDLISEFPDK 809
IL+YE ++ Q N RP+I++GP ++ + L+++ D+
Sbjct: 463 ----------------ILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDR 506
Query: 810 FGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRF 869
F S VPHTTR +RD EV GRDYHFV SR+ E DI KFIE G++ NLYGTS+ SVR
Sbjct: 507 FASAVPHTTRSRRDQEVAGRDYHFV-SRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQ 565
Query: 870 VAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEM----NKRLTEEQAKKTY 925
V GK C+L + ++K L+ + L P IFI P S E L + K E+ ++
Sbjct: 566 VINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREII 625
Query: 926 DRAIKLEQEFGEYF-TAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 971
++ ++EQ G YF TAIV D L+ Y + +I + W+PS
Sbjct: 626 EKTREMEQNNGHYFDTAIVNSD-LDKAYQELLRLINKLDTEPQWVPS 671
Score = 34.7 bits (78), Expect = 0.45
Identities = 15/48 (31%), Positives = 27/48 (56%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 372
+S+ +++I+ GGAA+K G L GD +L +N + E +L +
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSD 323
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 198 bits (504), Expect = 2e-50
Identities = 149/479 (31%), Positives = 229/479 (47%), Gaps = 71/479 (14%)
Query: 521 EGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDL 580
E + + L K LG I E I V+ I+ GG AD SG + GD++ VNGI +
Sbjct: 134 EDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPV 193
Query: 581 RGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQ 640
E+ + I+AQ Q + + GS ++
Sbjct: 194 EDKRPEEI----------IQILAQSQGA----------------ITFKIIPGSKEETPSK 227
Query: 641 KRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-E 697
+ ++++A+FDY+ ++D +P + GLSFK GDIL +++ D WWQA+ E D+
Sbjct: 228 EGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKH---EADANPR 284
Query: 698 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFP-----FYKN 752
G+IPSK ER R L+ + +P + ++ S + KSF SRK Y+
Sbjct: 285 AGLIPSKHFQER--RLALRRPEILVQPLKVSNRKSSGFR--KSFRLSRKDKKTNKSMYEC 340
Query: 753 KEQSEQETSDPERGQEDLILSYEPVT---RQEINYTRPVIILGPMKDRIND---DLISEF 806
K+ + +T+D + +YE VT RQ R V+++GP+ +N+ L+
Sbjct: 341 KKSDQYDTAD--------VPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISD 392
Query: 807 PDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQS 866
+G VPHTTR +R E DG +Y F IS+ E D+Q +KFIE G+Y +N YGTS+ S
Sbjct: 393 TQHYGVTVPHTTRARRSQESDGVEYIF-ISKHLFETDVQNNKFIEYGEYKNNYYGTSIDS 451
Query: 867 VRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKR----------- 915
VR V + K C+LDV + +K L+ + P IFIKP S+E L E K
Sbjct: 452 VRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQG 511
Query: 916 ----LTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 970
TEE ++ A +E ++G F I+ D L +N+ K ++ W+P
Sbjct: 512 AAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/88 (30%), Positives = 44/88 (50%), Gaps = 6/88 (6%)
Query: 294 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 353
++V I+L K + LG +I + +I V +I+ GGAA + G + VGD L V
Sbjct: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
Query: 354 NNYSLEEVTHEEAVAILKNTSEVVYLKV 381
N +E+ EE + IL + + K+
Sbjct: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 182 bits (461), Expect = 2e-45
Identities = 137/482 (28%), Positives = 231/482 (47%), Gaps = 77/482 (15%)
Query: 527 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586
V L K LG I E + V+ I+ GG AD SG + GD++ VNGI + +
Sbjct: 138 VRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPD 197
Query: 587 QAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 644
+ + L + ++T II Q ED + E+K+
Sbjct: 198 EISQILAQSQGSITLKIIPATQEEDRLK-ESKV--------------------------- 229
Query: 645 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSE-EMGVI 701
++RA+F Y+ +D +P Q GL F+ +L V++ D WWQA+RV GD+ G+I
Sbjct: 230 FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRV---GDTNLRAGLI 286
Query: 702 PSKRRVERKERARLKTVKFNAKPGVIDSKGSFN--------DKR--------KKSFIFSR 745
PSK ER+ + + G + S S DK K ++
Sbjct: 287 PSKGFQERR-------LSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGL 339
Query: 746 KFPFY---KNKEQSEQETSDPERGQEDLILSYEPVTR---QEINYTRPVIILGPMKDRIN 799
+ F + + QE + +L+YE V R Q R V+++G + R++
Sbjct: 340 RRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLH 399
Query: 800 D---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYN 856
+ +++E P FG VPHTTRP++ +E +G +YHFV S++ E D+ +KF+E G+Y
Sbjct: 400 ELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFV-SKQAFEADLHHNKFLEHGEYK 458
Query: 857 DNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR--------SLEP 908
+NLYGTS+++++ V + K C++DV A+K+L+ ++ P IF+KP + P
Sbjct: 459 ENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSP 518
Query: 909 LMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIW 968
E +EQ ++ A +++ +G A++ + L+ Y+Q K+V+E+ S W
Sbjct: 519 ACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHW 578
Query: 969 IP 970
+P
Sbjct: 579 VP 580
Score = 38.1 bits (87), Expect = 0.040
Identities = 26/88 (29%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 294 ETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMV 353
E+V ++L K + LG +I ++H ++ V +I+ GGAA + G + VGD L V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 354 NNYSLEEVTHEEAVAILKNTSEVVYLKV 381
N ++ +E IL + + LK+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKI 214
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 178 bits (452), Expect = 2e-44
Identities = 131/453 (28%), Positives = 215/453 (47%), Gaps = 74/453 (16%)
Query: 535 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594
G+ F + GGE + ++ IL GG G L GD I VNG + G+ L+
Sbjct: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
Query: 595 AGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDY 652
A +V I+ YQ + R ++V+ FDY
Sbjct: 207 ASGSVILKILPSYQ------------------------------EPHLPRQVFVKCHFDY 236
Query: 653 DKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERK 710
D ++DS +P + GL F GD+L ++N D WWQA V EG S G+IPS+ E++
Sbjct: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV--EGGSA--GLIPSQLLEEKR 292
Query: 711 ERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDL 770
+ + ++ G + GS + K+KK ++ KN E E
Sbjct: 293 KAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYLTT----KNAEFDRHE----------- 335
Query: 771 ILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVD 827
+L YE V R + ++++G + + + LI PD++G+ VP+T+R +D E +
Sbjct: 336 LLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
Query: 828 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 887
G+ Y FV SR +ME D++ +++E G+Y NLYGT + S+R V GK C+LDV+ A+K
Sbjct: 396 GQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVK 454
Query: 888 RLQVAQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYDRAIKLEQEFGE 937
L+ A+ P +FI+ E L MN K+LTE ++T + + ++++ +G
Sbjct: 455 VLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGH 514
Query: 938 YFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 970
YF + LE + + + +E+ W+P
Sbjct: 515 YFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 172 bits (437), Expect = 1e-42
Identities = 172/705 (24%), Positives = 298/705 (42%), Gaps = 147/705 (20%)
Query: 287 RRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQV 346
R+ RP +E +K+ KG + LG SI G IYV+K+ G A + G L+
Sbjct: 1339 RKDRPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEY 1390
Query: 347 GDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPM 406
GD+LL N +L T ++A I+ + + I Y+P +
Sbjct: 1391 GDQLLEFNGINLRSATEQQARLIIGQQCDTI-------------------TILAQYNPHV 1431
Query: 407 ENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASP 466
H LS ++ S P H + T PE S ++ L ++ P
Sbjct: 1432 --HQLSSHSR-----------SSSHLDPAGTHSTLQGSGTTTPEHP-SVIDPLMEQDEGP 1477
Query: 467 RHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK 526
P ++ +S A ++ TL EPR
Sbjct: 1478 S------------------------TPPAKQSSSRIAGDANKK---TL--------EPRV 1502
Query: 527 VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 586
V + K LG ++ GG + G+FV+ + PA L GD IL +D+R + E
Sbjct: 1503 VFIKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVE 1561
Query: 587 QAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYV 646
+ + V + QY+PE++ + + D S Y+
Sbjct: 1562 EVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGD-----------------------SFYI 1598
Query: 647 RAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPS 703
RA+ YD+ D Q LSFK DIL+V + W A ++ + G IPS
Sbjct: 1599 RAL--YDRLADV---EQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPS 1653
Query: 704 KRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQE---- 759
K ++++ RL + + + ++SF F RK +K+K ++
Sbjct: 1654 KYVMDQEFSRRLSMSEVKDDNSATKTLSA---AARRSF-FRRK---HKHKRSGSKDGKDL 1706
Query: 760 ------TSDPERGQEDLI-LSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGS 812
+SD ED + L+Y+ V + + RPV+ILGP+ D + + L++E P KF
Sbjct: 1707 LALDAFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCR 1766
Query: 813 CVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAE 872
C + S++ +E+ +++ F++ + + + T+V S++ + E
Sbjct: 1767 CPLEVMKA---------------SQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITE 1811
Query: 873 RGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLME------MNKRLTEEQAKKTYD 926
+ +HC+LD++ +AI+RL +YPI IFI +S + + E + ++T+ +K+ ++
Sbjct: 1812 KNRHCLLDIAPHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFE 1871
Query: 927 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPS 971
A KLEQE+ YFT ++QG L I Q ++ ++ +WIP+
Sbjct: 1872 AAQKLEQEYSRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 103 bits (256), Expect = 1e-21
Identities = 109/415 (26%), Positives = 183/415 (44%), Gaps = 83/415 (20%)
Query: 22 TLLNSQKSCEQKIEEANQVLQKW-----EKTSLLAPCHDRLQKSSELTDCSGSKENASCI 76
T + + K E+ EE + V ++ E+ +++ D+LQ EL + SK +S
Sbjct: 410 TQVKTAKESEKYREERDAVYSEYKLIMSERDQVISEL-DKLQTEVELAE---SKLKSSTS 465
Query: 77 EQNKENQSFE--NETDETTTQNQGRCPAQ------NCSV------EAPAWMPVHHCTK-Y 121
E+ N+ E + +T T + GR + C EA V C + +
Sbjct: 466 EKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDW 525
Query: 122 RYQDEDA-----------------PHDHSLPRLTHEVRG------------PELVHVSEK 152
+Q+ D D ++ L +R EL + E+
Sbjct: 526 AFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQ 585
Query: 153 NLSQIENVHGY-VLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNS 211
SQ+E + L +H S A ++TD+++ V E E E E+I L+
Sbjct: 586 MESQLEKEARFRQLMAHSSHDSA------IDTDSMEWETEV--VEFERETEDIDLK---- 633
Query: 212 GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKA 271
LGF +A G + P D GIF+TK+ G A DGRLRVND +LR+N+VD+ +A
Sbjct: 634 ALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIA--DGRLRVNDWLLRINDVDLINKDKKQA 691
Query: 272 VEALKEAGSIVRLYVRRRRPI---LETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIY 328
++AL + + VRRR+ + + T + I L G K G S+ +N +Y
Sbjct: 692 IKALLNGEGAINMVVRRRKSLGGKVVTPLHINL-SGQKDSGISL-----------ENGVY 739
Query: 329 VTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
++ G A K+G L VGDR++ +N +L+ + E ++L++ + + L + K
Sbjct: 740 AAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLK 794
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 517 AVSLEGEPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQ 571
A+++ RK + K T L N+ G +D G++ + +L G PA G L GD+
Sbjct: 701 AINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDR 760
Query: 572 ILSVNGIDLRGASHEQAAAALKGAGQTVTI 601
I+++NGI L S + + L+ ++T+
Sbjct: 761 IVAINGIALDNKSLNECESLLRSCQDSLTL 790
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 169 bits (427), Expect = 2e-41
Identities = 134/505 (26%), Positives = 226/505 (44%), Gaps = 88/505 (17%)
Query: 525 RKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
R V L K LG I E I V+ I+ GG A+ SG L GD+++ VNG+ + G
Sbjct: 153 RIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLD 212
Query: 585 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 644
EQ L + T+ K+ + + +N ++ +
Sbjct: 213 PEQVIHILAMSRGTIMF--------------KVVPVSDPPVN-------------SQQMV 245
Query: 645 YVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIP 702
YVRAM +Y +D +P GL F+ GDIL +++ +D WWQAR++ + G++P
Sbjct: 246 YVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI--SDPATCAGLVP 303
Query: 703 SKRRVERKERARLKTVKFNA----KPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQ 758
S ++RK+R + + K + S +D + ++++E SE
Sbjct: 304 SNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSED 363
Query: 759 ETSDPERGQEDLILS----------------------------------YEPVTRQEINY 784
+ GQ+ I YE V R +
Sbjct: 364 KEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRP 423
Query: 785 T---RPVIILGPMKDRIND---DLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 838
+ R ++++GP +N+ LI P F S VPHTTR K+ YE++GR+YH+V S+E
Sbjct: 424 SDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYV-SKE 482
Query: 839 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 898
E I H+ +E G+Y +LYGTSV +V+ V GK C++D+ I+ ++ +L P
Sbjct: 483 TFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYV 542
Query: 899 IFIKPRSLEPLMEMNK------------RLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGD 946
IFIKP ++ + + K + +E ++ + A ++E +FG++F ++ D
Sbjct: 543 IFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVND 602
Query: 947 TLEDIYNQCKLVIEEQSGPFIWIPS 971
+L D Q I++ W+P+
Sbjct: 603 SLHDACAQLLSAIQKAQEEPQWVPA 627
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 6/81 (7%)
Query: 301 LFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEE 360
L K + LG +I + GD I V +II GG A++ G L GD+L+ VN S+E
Sbjct: 157 LVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210
Query: 361 VTHEEAVAILKNTSEVVYLKV 381
+ E+ + IL + + KV
Sbjct: 211 LDPEQVIHILAMSRGTIMFKV 231
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 167 bits (424), Expect = 3e-41
Identities = 127/445 (28%), Positives = 209/445 (46%), Gaps = 76/445 (17%)
Query: 545 DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--II 602
+ + ++ IL GG D G L GD I VNG ++ G + ++ LK +VT I+
Sbjct: 148 ENNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEV-GNNPKELQELLKNISGSVTLKIL 206
Query: 603 AQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPS 662
Y+ T + ++V+ FDY+ D+ +P
Sbjct: 207 PSYRD------------------------------TITPQQVFVKCHFDYNPYNDNLIPC 236
Query: 663 Q--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKF 720
+ GL F G+IL ++N D WWQA V G + G+IPS+ +E K +A ++
Sbjct: 237 KEAGLKFSKGEILQIVNREDPNWWQASHVKEGGSA---GLIPSQF-LEEKRKAFVRRDWD 292
Query: 721 NAKP--GVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVT 778
N+ P G I SK K+K ++ +R F +++ Q YE V
Sbjct: 293 NSGPFCGTISSK----KKKKMMYLTTRNAEFDRHEIQI-----------------YEEVA 331
Query: 779 RQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVI 835
+ + ++++G + + + I P +FG+ VP T+R R+ E DG+ Y FV
Sbjct: 332 KMPPFQRKTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFV- 390
Query: 836 SREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLY 895
SR +ME DI+ K++E G+Y NLYGT + S+ V + G+ CILDV+ A+K L+ ++
Sbjct: 391 SRSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFM 450
Query: 896 PIAIFIKPRSLEPLMEMNKR----------LTEEQAKKTYDRAIKLEQEFGEYFTAIVQG 945
P +FI LE L M+K LT+ KKT D + ++++ + YF I+
Sbjct: 451 PYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIIN 510
Query: 946 DTLEDIYNQCKLVIEEQSGPFIWIP 970
D L+ + + + IE+ W+P
Sbjct: 511 DNLDKAFEKLQTAIEKLRMEPQWVP 535
Score = 34.7 bits (78), Expect = 0.45
Identities = 19/58 (32%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
+N + + +I+ GG + G L VGD + VN + + +E +LKN S V LK+
Sbjct: 149 NNDLVIARILHGGMIDRQGLLHVGDIIKEVNGHEVGN-NPKELQELLKNISGSVTLKI 205
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 158 bits (399), Expect = 3e-38
Identities = 114/432 (26%), Positives = 208/432 (48%), Gaps = 42/432 (9%)
Query: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 608
V+ I+ GG G L GD+I +NGI + + EQ L+ ++T I+ Y+ +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 609 DYARFEAKIHDLREQMMN-HSMSSGSGS---LRTNQK-RSLYVRAMFDYDKSKDSGLPSQ 663
+ R+ N HS ++ S S T K R +YVRA F+YD +KD +P +
Sbjct: 575 SSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCK 634
Query: 664 --GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFN 721
G+ F+ GDI+ +I+ D WWQ + + + G+IPS E +
Sbjct: 635 EAGIRFRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVAC-------- 684
Query: 722 AKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQE 781
I + + +++ F +K YK+K ++ +++YE V +
Sbjct: 685 -----IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAD---------LVTYEEVVKLP 730
Query: 782 INYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 838
+ +++LG + I + LI++ PD+F +PHTTRP + E +G++Y+FV S +
Sbjct: 731 AFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHD 789
Query: 839 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 898
QM +DI ++++E G + D +YGT ++++R + E+G ILDV A+K L+ A+ P
Sbjct: 790 QMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFV 849
Query: 899 IFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLV 958
+FI ++ P + ++ L Q + L++ + YF + + +++ +
Sbjct: 850 VFIAAPTITPGLNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEA 904
Query: 959 IEEQSGPFIWIP 970
+E W+P
Sbjct: 905 VELVCTAPQWVP 916
Score = 32.7 bits (73), Expect = 1.7
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
N V +I+ GG + G L VGD + +N S+ T E+ +L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 156 bits (395), Expect = 8e-38
Identities = 114/426 (26%), Positives = 198/426 (46%), Gaps = 66/426 (15%)
Query: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDY 610
V+ IL GG G L GD+IL +NG ++ S +Q A+K +++ + P
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
Query: 611 ARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFK 668
+R A +++RA FDYD KD+ +P + GL F
Sbjct: 154 SRLPA--------------------------LQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
Query: 669 YGDILHVINASDDEWWQARRVMLEGDSEE-MGVIPSKRRVERKERARLKTVKFNAKPGVI 727
GDI+ +IN D WWQ R +EG S+E G+IPS E + + ++ P
Sbjct: 188 TGDIIQIINKDDSNWWQGR---VEGSSKESAGLIPSPELQEWRVASMAQSA-----PSEA 239
Query: 728 DSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRP 787
S F K+K YK+K ++ + + ++SYE V R +
Sbjct: 240 PSCSPFGKKKK-----------YKDKYLAKHSSIFDQLD----VVSYEEVVRLPAFKRKT 284
Query: 788 VIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDI 844
++++G + I + L+S+ P+KF VP+TTRP R E DG++YHF IS E+M ++I
Sbjct: 285 LVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHF-ISTEEMTRNI 343
Query: 845 QEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPR 904
++F+E G Y N++GT ++V + ++ K ILD+ +K ++ A+L P +FI P
Sbjct: 344 SANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPT 403
Query: 905 SLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSG 964
E ++L ++ + ++ YF + + +++ + + ++
Sbjct: 404 DQGTQTEALQQLQKDSE--------AIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACS 455
Query: 965 PFIWIP 970
W+P
Sbjct: 456 SPQWVP 461
Score = 35.4 bits (80), Expect = 0.26
Identities = 17/56 (30%), Positives = 30/56 (53%)
Query: 326 SIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
S V +I+ GG + G L VGD +L +N ++ + ++ +K T ++ LKV
Sbjct: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
Score = 35.4 bits (80), Expect = 0.26
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 12/121 (9%)
Query: 234 ITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV----RRR 289
+ +I+ GG G L V D IL +N +V+ S + +A+KE ++ L V + R
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSR 155
Query: 290 RPILETVVEIKLFKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKD 341
P L+ + + P K G A G Q I D+S + ++G + +
Sbjct: 156 LPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESA 215
Query: 342 G 342
G
Sbjct: 216 G 216
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 156 bits (394), Expect = 1e-37
Identities = 165/686 (24%), Positives = 275/686 (40%), Gaps = 156/686 (22%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 384
+ I++ I D G A + LQ GD +L +N S + ++ L +T ++ GK
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLS-------LNDTRRLIEKSEGKL 283
Query: 385 TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP-ISPGRYSPIPKHMLVDD 443
+ + + D ++ ++PP +S SP+ + + + D
Sbjct: 284 SLLVLRDRG-------------------------QFLVNIPPAVSDSDSSPLEEGVTMAD 318
Query: 444 DYTRPPEPVYSTVNKLCDKPAS-----PRHY--SPVECDKSFLLSAPYSHYHLGLLPDSE 496
+ + PP + ++L P S PRH SP + +P + +
Sbjct: 319 EMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTI 378
Query: 497 MTSHSQHSTATRQPSMTLQRAVSLEG--------EPRKVVLHKGSTGLGFNIVGGEDGEG 548
Q S R+ S + R S + + R V KG + +G + GG D G
Sbjct: 379 SEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKS-IGLRLAGGND-VG 436
Query: 549 IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQ 606
IFVS + AG PAD G +Q GDQIL VN + + + E+A L G G+ + ++ Q +
Sbjct: 437 IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRK 495
Query: 607 PEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGL 665
+ + + ++++ D S Y+R F+ + S P GL
Sbjct: 496 QDIFWKMVQSRVGD-----------------------SFYIRTHFELEPS-----PPSGL 527
Query: 666 SFKYGDILHVINA---------SDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLK 716
F GD+ HV++ + W A R+ + +E G+IP++ R E + A L+
Sbjct: 528 GFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAE--QLASLE 585
Query: 717 TVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---- 772
+ G S GS + + F++ + +R +EDL
Sbjct: 586 AAQRAVGVGPGSSAGS-----------NARAEFWRLRGLRRGAKKTTQRSREDLSALTRQ 634
Query: 773 ----SYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKF--GSCVPHTTRPKRDYEV 826
YE V +E ++ RPV+ILGP+ D L +E PD+F V T P + ++
Sbjct: 635 GRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKL 694
Query: 827 DGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAI 886
D +VR +AE+ KH +LDV+ +AI
Sbjct: 695 D--------------------------------------TVRVIAEKDKHALLDVTPSAI 716
Query: 887 KRLQVAQLYPIAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIV 943
+RL Q YPI +F P S L + + L + ++ Y +A KL + FTA +
Sbjct: 717 ERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATI 776
Query: 944 Q-GDTLEDIYNQCKLVIEEQSGPFIW 968
T + Y + K +I EQ IW
Sbjct: 777 PLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/90 (37%), Positives = 54/90 (60%), Gaps = 7/90 (7%)
Query: 301 LFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 359
L K P+ G G +I+GG + PG S+ V+ ++ GG A+ GRLQ GD ++MVN S+E
Sbjct: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSME 86
Query: 360 EVTHEEAVAILKNTSEVVYLKVGKPTTIYM 389
T A+ ILK +++ + V +P I++
Sbjct: 87 NATSAFAIQILKTCTKMANITVKRPRRIHL 116
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/81 (37%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 515 QRAVSLEGEPRKVVLHKGSTGLGFNIVGGED--GEGIFVSFILAGGPADLSGELQRGDQI 572
Q +L +PR+ G G I GG D G + VS ++ GGPA+ G LQ GD I
Sbjct: 28 QHTATLSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHI 77
Query: 573 LSVNGIDLRGASHEQAAAALK 593
+ VNG+ + A+ A LK
Sbjct: 78 VMVNGVSMENATSAFAIQILK 98
Score = 39.3 bits (90), Expect = 0.018
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 9/72 (12%)
Query: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
++ KG K +G +AGG D I+V+ + G A G +Q GD++L VN+
Sbjct: 417 VRFLKG-KSIGLRLAGG-------NDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPF 467
Query: 359 EEVTHEEAVAIL 370
+ +T EEAV L
Sbjct: 468 QNLTREEAVQFL 479
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 152 bits (385), Expect = 1e-36
Identities = 111/427 (25%), Positives = 204/427 (47%), Gaps = 50/427 (11%)
Query: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 608
V+ I+ GG G L GD+I +NGI + + EQ L+ ++T I+ Y+ +
Sbjct: 509 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 568
Query: 609 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLS 666
+ E + + + G R +YVRA F+YD +KD +P + G+
Sbjct: 569 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 610
Query: 667 FKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGV 726
F+ GDI+ +I+ D WWQ + + + G+IPS E +
Sbjct: 611 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVAC------------- 655
Query: 727 IDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTR 786
I + + +++ F +K YK+K ++ Q DL+ +YE V + +
Sbjct: 656 IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFD---QLDLV-TYEEVVKLPAFKRK 711
Query: 787 PVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKD 843
+++LG + I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +D
Sbjct: 712 TLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQD 770
Query: 844 IQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKP 903
I ++++E G + D +YGT ++++R + E+G ILDV A+K L+ A+ P +FI
Sbjct: 771 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 830
Query: 904 RSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQS 963
++ P + ++ L Q + L++ + YF + + +++ + +E
Sbjct: 831 PTITPGLNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVC 885
Query: 964 GPFIWIP 970
W+P
Sbjct: 886 TAPQWVP 892
Score = 32.7 bits (73), Expect = 1.7
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
N V +I+ GG + G L VGD + +N S+ T E+ +L+ + K+
Sbjct: 505 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 561
Score = 30.8 bits (68), Expect = 6.5
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 6/126 (4%)
Query: 188 TIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNP-----HIGDDPGIFITKIIPGGA 242
T PY+NG E ++ +E TD P + + + +I+ GG
Sbjct: 458 TSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGM 517
Query: 243 AAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKE-AGSIVRLYVRRRRPILETVVEIKL 301
G L V D I +N + V+ + + + L+E GSI V R + ++
Sbjct: 518 IHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPS 577
Query: 302 FKGPKG 307
PKG
Sbjct: 578 TTQPKG 583
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 152 bits (385), Expect = 1e-36
Identities = 108/427 (25%), Positives = 202/427 (47%), Gaps = 55/427 (12%)
Query: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPE 608
V+ I+ GG G L GD+I +NGI + + EQ L+ ++T I+ Y+ +
Sbjct: 515 VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQ 574
Query: 609 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLS 666
+ E + + + G R +YVRA F+YD +KD +P + G+
Sbjct: 575 SSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDLIPCKEAGIR 616
Query: 667 FKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGV 726
F+ GDI+ +I+ D WWQ + + + G+IPS E +
Sbjct: 617 FRVGDIIQIISKDDHNWWQGK--LENSKNGTAGLIPSPELQEWRVAC------------- 661
Query: 727 IDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTR 786
I + + +++ F +K YK+K ++ +++YE V + +
Sbjct: 662 IAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAD---------LVTYEEVVKLPAFKRK 712
Query: 787 PVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKD 843
+++LG + I + LI++ PD+F +PHTTRP + E +G++Y+FV S +QM +D
Sbjct: 713 TLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFV-SHDQMMQD 771
Query: 844 IQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKP 903
I ++++E G + D +YGT ++++R + E+G ILDV A+K L+ A+ P +FI
Sbjct: 772 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 831
Query: 904 RSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQS 963
++ P + ++ L Q + L++ + YF + + +++ + +E
Sbjct: 832 PTITPGLNEDESLQRLQKESDI-----LQRTYAHYFDLTIINNEIDETIRHLEEAVELVC 886
Query: 964 GPFIWIP 970
W+P
Sbjct: 887 TAPQWVP 893
Score = 32.7 bits (73), Expect = 1.7
Identities = 16/57 (28%), Positives = 27/57 (47%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
N V +I+ GG + G L VGD + +N S+ T E+ +L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
Score = 30.8 bits (68), Expect = 6.5
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 6/126 (4%)
Query: 188 TIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNP-----HIGDDPGIFITKIIPGGA 242
T PY+NG E ++ +E TD P + + + +I+ GG
Sbjct: 464 TSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGM 523
Query: 243 AAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKE-AGSIVRLYVRRRRPILETVVEIKL 301
G L V D I +N + V+ + + + L+E GSI V R + ++
Sbjct: 524 IHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPS 583
Query: 302 FKGPKG 307
PKG
Sbjct: 584 TTQPKG 589
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 145 bits (366), Expect = 2e-34
Identities = 164/621 (26%), Positives = 264/621 (42%), Gaps = 106/621 (17%)
Query: 122 RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 181
R Q E+ + P+ E E E+ ++ E+ G V+ ++P+ V
Sbjct: 656 RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
Query: 182 NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 240
+ D + + + IE E +T+ R GLG SIAGG + P+ GDD GIFI+++
Sbjct: 708 SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
Query: 241 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-LETVVEI 299
G AA G +RV D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 767 GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
Query: 300 K--------------------------------------LFKGPKGLGFSIAGGVGN-QH 320
L + +GLGFSIAGG G+ +
Sbjct: 826 TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
Query: 321 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 380
GD I+V++I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L
Sbjct: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
Query: 381 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 432
+ + P P + HS SPP + LP ++P G Y
Sbjct: 946 LEREA----GGPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
Query: 433 -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 478
P+ ++ D++ P V ++K+ + + R V D+
Sbjct: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
Query: 479 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 534
++ D +H + +A +P + L V + P R++ + K
Sbjct: 1060 AVNG----------QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
Query: 535 GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
LG +I GG G EGIF+S + G A G L+ G ++L VN L G +
Sbjct: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
Query: 585 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 644
H +A L+ G T+T++ E A +A + ++ ++ + ++G G + + S
Sbjct: 1170 HGEAVQLLRSVGDTLTVLVCDGFE--ASTDAAL-EVSPGVIANPFAAGIGHRNSLESISS 1226
Query: 645 YVRAMFDYDKSKDSGLPSQGL 665
R + K+ LP Q L
Sbjct: 1227 IDRELSPEGPGKEKELPGQTL 1247
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 145 bits (366), Expect = 2e-34
Identities = 164/621 (26%), Positives = 264/621 (42%), Gaps = 106/621 (17%)
Query: 122 RYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV 181
R Q E+ + P+ E E E+ ++ E+ G V+ ++P+ V
Sbjct: 656 RAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVV--------SAPSVKGV 707
Query: 182 NTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDN-PHIGDDPGIFITKIIPG 240
+ D + + + IE E +T+ R GLG SIAGG + P+ GDD GIFI+++
Sbjct: 708 SFDQANNL-LIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEE 766
Query: 241 GAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI-LETVVEI 299
G AA G +RV D +L VN V + H +AVEAL+ AG+ V++ V R R + E V I
Sbjct: 767 GPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTI 825
Query: 300 K--------------------------------------LFKGPKGLGFSIAGGVGN-QH 320
L + +GLGFSIAGG G+ +
Sbjct: 826 TPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPY 885
Query: 321 IPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLK 380
GD I+V++I +GGAA + G LQVGDR+L +N + E H+ AV++L S + L
Sbjct: 886 RAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALL 945
Query: 381 VGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISP--------GRY 432
+ + P P + HS SPP + LP ++P G Y
Sbjct: 946 LEREA----GGPLPPSPLPHS-SPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPY 1000
Query: 433 -----------SPIPKHMLVDDDYTRPPEPVYST---VNKLCDKPASPRHYSPVECDKSF 478
P+ ++ D++ P V ++K+ + + R V D+
Sbjct: 1001 PVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVG-DRIL 1059
Query: 479 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEP---RKVVLHKG-ST 534
++ D +H + +A +P + L V + P R++ + K
Sbjct: 1060 AVNG----------QDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGE 1109
Query: 535 GLGFNIVGGEDG----------EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
LG +I GG G EGIF+S + G A G L+ G ++L VN L G +
Sbjct: 1110 RLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLT 1169
Query: 585 HEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSL 644
H +A L+ G T+T++ E A +A + ++ ++ + ++G G + + S
Sbjct: 1170 HGEAVQLLRSVGDTLTVLVCDGFE--ASTDAAL-EVSPGVIANPFAAGIGHRNSLESISS 1226
Query: 645 YVRAMFDYDKSKDSGLPSQGL 665
R + K+ LP Q L
Sbjct: 1227 IDRELSPEGPGKEKELPGQTL 1247
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 139 bits (349), Expect = 2e-32
Identities = 143/462 (30%), Positives = 203/462 (43%), Gaps = 64/462 (13%)
Query: 175 SPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFI 234
S P I +D T P + G E E + +G +GLG SI GG+D +G I I
Sbjct: 1607 SSTPAIFASDPA-TCPIIPGCETTIE-----ISKGRTGLGLSIVGGSDTL-LG---AIII 1656
Query: 235 TKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR-RRPIL 293
++ GAA +DGRL D IL VN +D+ + +H +A+ L++ VRL + R P
Sbjct: 1657 HEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1716
Query: 294 ETVV----EIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGD 348
E V I+L K P KGLG SI G D ++V+ I+ GG A DGRL GD
Sbjct: 1717 EEEVCDTLTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGD 1770
Query: 349 RLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSY-SPPME 407
++LMVN + T +EAVA L LKV + + T P + S S +
Sbjct: 1771 QILMVNGEDVRNAT-QEAVAAL--------LKVSEGSLSSFTFPLSGSSTSESLESSSKK 1821
Query: 408 NHLLSGNNGTLEYKTSLPP-------ISPGRYSPI-----------PKHMLVDDDYTRPP 449
N L S G + P I+ G SP+ P + R
Sbjct: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVG 1881
Query: 450 EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 509
+ + + + H V K+ S G + S +T H Q ++
Sbjct: 1882 DRIVTICGTSTE---GMTHTQAVNLLKNASGSIEMQVVAGGDV--SVVTGHQQEPASSSL 1936
Query: 510 PSMTLQRAVSLE---GEP--RKVVLHKGSTGLGFNIVGGEDGEG----IFVSFILAGGPA 560
L + + G P + + L +G GLGF+IVGG I+V + A G A
Sbjct: 1937 SFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAA 1996
Query: 561 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602
G L+RGDQI++VNG L G +HE+A A LK TVT++
Sbjct: 1997 SEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
Score = 119 bits (297), Expect = 2e-26
Identities = 91/274 (33%), Positives = 135/274 (49%), Gaps = 42/274 (15%)
Query: 141 VRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYE 200
V G ++ + +++ ++ + V L S PL S +++L++ N E +
Sbjct: 1775 VNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSST-----SESLESSSKKNALASEIQ 1829
Query: 201 -FEEITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 258
+ +++G LG SIAGG +P +GD P IFI + P G AA+ +LRV D I+ +
Sbjct: 1830 GLRTVEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTI 1887
Query: 259 NEVDVSEVSHSKAVEALKEAGSIVRLYV-----------RRRRPILETVV---------- 297
++H++AV LK A + + V ++ P ++
Sbjct: 1888 CGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIF 1947
Query: 298 ----------EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 347
I L +GP GLGFSI GG G+ H GD IYV + GAA +DGRL+ G
Sbjct: 1948 QDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRG 2005
Query: 348 DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
D+++ VN SLE VTHEEAVAILK T V L V
Sbjct: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 110 bits (275), Expect = 6e-24
Identities = 109/462 (23%), Positives = 195/462 (42%), Gaps = 98/462 (21%)
Query: 177 APIIVNTDTLDTIPYVNGTEIEYE-FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 235
+PI+ + + + + + ++ E I L SGLGF I GG G+ +
Sbjct: 230 SPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT-------GVIVK 282
Query: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR------- 288
I+PGG A + GRL D IL++ + D++ +S + + L++ G+ V+L + R
Sbjct: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT 342
Query: 289 --------------RRPILET-----------VVEIKLFKGPKGLGFSIAGGVGNQHIPG 323
P L +++L K +GLG +IAG +G++ +
Sbjct: 343 APTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE- 401
Query: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
+ I+V I A + DGR+Q+GD+++ V+ +L+ T+++AV +L++T + V L + +
Sbjct: 402 PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
Query: 384 PTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD 443
E L+S + T + L P++ ++ +
Sbjct: 462 ------------------RGMKQEAELMSREDVTKD--ADLSPVNAS---------IIKE 492
Query: 444 DYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQH 503
+Y + + + ST N + P E + LLSA + E +Q
Sbjct: 493 NYEKDEDFLSSTRN---------TNILPTEEEGYPLLSA-----------EIEEIEDAQK 532
Query: 504 STATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI---VGGEDGEGIFVSFILAGGPA 560
A ++ E V ++GLG ++ VG F+ +L GP
Sbjct: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVLPEGPV 587
Query: 561 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602
SG+L GD++L VNGI L G +H+ LK VT++
Sbjct: 588 GHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
Score = 99.4 bits (246), Expect = 1e-20
Identities = 112/475 (23%), Positives = 182/475 (38%), Gaps = 131/475 (27%)
Query: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
I + +GNS LG +++ D G+ + II GGA + DGR+ + DCIL +NE
Sbjct: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 264 SEVSHSKAVEALK----------------------------EAGSIVRL-----YVRRRR 290
V++++A L+ ++G ++ L Y R
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
Query: 291 PILETVVE---------------------IKLFKGP-KGLGFSIAGG--VGNQHIPGD-- 324
P L E ++L++ P K LG SI GG +G++ G+
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 384
I++ +++ A K+G L+ GDR++ V+ L + +HE+AV ++ K G P
Sbjct: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR--------KAGNP 1234
Query: 385 TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK--HMLVD 442
+ P R SP+P H L
Sbjct: 1235 VVFMVQSIINRP----------------------------------RKSPLPSLLHNLYP 1260
Query: 443 DDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQ 502
P ++ DK S P + + P S + +EM S
Sbjct: 1261 KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAF-------AEMGSDHT 1313
Query: 503 HSTATRQPSMT-------------LQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE-- 547
S+A++ +R +L GE + L KG +GLG ++ G +D
Sbjct: 1314 QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373
Query: 548 GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602
+F+ I G A G LQ D++L +NG L G SH+ A++ +K A V II
Sbjct: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKII 1428
Score = 85.9 bits (211), Expect = 2e-16
Identities = 127/459 (27%), Positives = 177/459 (38%), Gaps = 123/459 (26%)
Query: 221 TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS 280
T+ PH+ D G FI G + ED L + D EV +A A+ EAG
Sbjct: 654 TEKPHV--DLGEFI-----GSSETEDPVLAMTDAGQSTEEV--------QAPLAMWEAG- 697
Query: 281 IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 340
+ I+L KG KGLGFSI + P I + ++ GG A+K
Sbjct: 698 ---------------IQHIELEKGSKGLGFSILD-YQDPIDPASTVIIIRSLVPGGIAEK 741
Query: 341 DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTI-----YMT---- 390
DGRL GDRL+ VN+ +LE + EEAV LK S V + V KP + Y++
Sbjct: 742 DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKED 801
Query: 391 -----------------------------------------DPYGPPD--ITHSYSPPME 407
PY P + I + + +
Sbjct: 802 SFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILS 861
Query: 408 NHLLSGNNGTLEYKTSLPPISP-----GRYSPI-PKHMLVDDDYT-----RPPEPVYS-- 454
H S +G L Y +SLP P P+ HM +++ YT R E S
Sbjct: 862 LHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVD 920
Query: 455 ---------TVNKLCDKPASPRHYSPVECD------KSFLLSAPYSHYHL-GLLPDSEMT 498
T+N A + Y EC+ +S L S S L +LPDS
Sbjct: 921 ISMGPASGFTINDYTPANAIEQQY---ECENTIVWTESHLPSEVISSAELPSVLPDSAGK 977
Query: 499 SHS----QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 554
Q S A + LQ VS E R + + KG++ LG + +DG G+ V I
Sbjct: 978 GSEYLLEQSSLACNAECVMLQN-VSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSI 1036
Query: 555 LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593
+ GG G + GD ILS+N ++ QA A L+
Sbjct: 1037 IHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/311 (28%), Positives = 131/311 (42%), Gaps = 84/311 (27%)
Query: 299 IKLFKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355
I + KG LG +++ G+G + V II GGA +DGR+ +GD +L +N
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 356 YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 415
S VT+ +A A+L+ S + PDI +Y P HL
Sbjct: 1060 ESTISVTNAQARAMLRRHSLI------------------GPDIKITYVPA--EHLE---- 1095
Query: 416 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECD 475
E+K SL G+ S + + YT D P P E +
Sbjct: 1096 ---EFKISL-----GQQSGRVMALDIFSSYTGR------------DIPELPEREEG-EGE 1134
Query: 476 KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV--VLHKGS 533
+S L + YS+++ QP R V L EP K + G
Sbjct: 1135 ESELQNTAYSNWN--------------------QP-----RRVELWREPSKSLGISIVGG 1169
Query: 534 TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593
G+G + GE GIF+ +L PA +G L+ GD+I+ V+G+DLR ASHEQA A++
Sbjct: 1170 RGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
Query: 594 GAGQTVTIIAQ 604
AG V + Q
Sbjct: 1230 KAGNPVVFMVQ 1240
Score = 75.5 bits (184), Expect = 2e-13
Identities = 77/304 (25%), Positives = 125/304 (41%), Gaps = 56/304 (18%)
Query: 147 VHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIV-NTDTLDT-----IPYVNGTEIEYE 200
V+++ S IE H L + P + + ++ N L+ IP++NG E
Sbjct: 62 VNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDE 121
Query: 201 FEEIT--------------LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAED 246
F+++ L+ + GLGFS+ G + GIF+ +I G A D
Sbjct: 122 FDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRD 179
Query: 247 GRLRVNDCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRR------------RRPIL 293
GRL+ D IL +N + + ++H +A+ L++A V+L + R R P
Sbjct: 180 GRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSA 239
Query: 294 ETVVE-------------IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 340
+ + I+L GLGF I GG + V I+ GG A +
Sbjct: 240 ASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQ 292
Query: 341 DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITH 400
GRL GD +L + + L ++ E+ +L+ V L + + T P IT
Sbjct: 293 HGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTA-LGITL 351
Query: 401 SYSP 404
S SP
Sbjct: 352 SSSP 355
Score = 71.6 bits (174), Expect = 3e-12
Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 40/218 (18%)
Query: 200 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
E I LE+G+SGLG S+AG D + +FI I P GAA +DGRL++ D +L +N
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEIN 1402
Query: 260 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-------------------------- 293
+ SH A +K A S V++ R + +
Sbjct: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
Query: 294 -------ETVVEIKLFKGPKGLGF-SIAGGVGNQHIPGD--NSIYVTKIIDGGAAQKDGR 343
+ V++ FK + L GG+G D + + + + + G A DGR
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
Query: 344 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381
L+VGD++L V++ + E+ +++LK V L +
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 61.2 bits (147), Expect = 4e-09
Identities = 44/118 (37%), Positives = 63/118 (53%), Gaps = 4/118 (3%)
Query: 178 PIIVNTDTLDTIPYVNGTEIEYE--FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 235
P++ TD + V +E + I LE+G+ GLGFSI D P I I
Sbjct: 673 PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
Query: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS-IVRLYVRRRRPI 292
++PGG A +DGRL D ++ VN+V++ S +AVEALK A S VR+ V + P+
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPL 789
Score = 60.5 bits (145), Expect = 8e-09
Identities = 69/260 (26%), Positives = 98/260 (37%), Gaps = 66/260 (25%)
Query: 192 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 251
+ G E ++ NSGLG S+ T H FI ++P G G+L
Sbjct: 544 IMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLFS 595
Query: 252 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRR--PILET------VVEIKLFK 303
D +L VN + + +H V LKE V + RR P ++ + +I+L +
Sbjct: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
Query: 304 GPK-GLGFSIAGG---------------------------VGNQHI-------------- 321
P LG I G QHI
Sbjct: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
Query: 322 -------PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT- 373
P I + ++ GG A+KDGRL GDRL+ VN+ +LE + EEAV LK
Sbjct: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAP 775
Query: 374 SEVVYLKVGKPTTIYMTDPY 393
S V + V KP + + Y
Sbjct: 776 SGTVRIGVAKPLPLSPEEGY 795
Score = 52.8 bits (125), Expect = 2e-06
Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 7/129 (5%)
Query: 486 HYHLG-LLPDSEMTSHSQHSTATRQPSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVGG 543
H LG + SE T Q + +Q +++ E + + L KGS GLGF+I+
Sbjct: 658 HVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
Query: 544 ED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 598
+D I + ++ GG A+ G L GD+++ VN ++L +S E+A ALKGA
Sbjct: 718 QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG 777
Query: 599 VTIIAQYQP 607
I +P
Sbjct: 778 TVRIGVAKP 786
Score = 46.6 bits (109), Expect = 1e-04
Identities = 33/80 (41%), Positives = 46/80 (57%), Gaps = 5/80 (6%)
Query: 528 VLHKGSTGLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RG 582
+L S GLGF++VG GE GIFV I G A G L+ DQIL++NG L +
Sbjct: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199
Query: 583 ASHEQAAAALKGAGQTVTII 602
+H+QA + L+ A TV ++
Sbjct: 200 ITHQQAISILQKAKDTVQLV 219
Score = 39.3 bits (90), Expect = 0.018
Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 6/95 (6%)
Query: 202 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 261
+ + L + GLG +I+ G+ I + G AA DGRL+V D IL V++
Sbjct: 1482 QHLELPKDQGGLGIAISEEDTLS------GVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
Query: 262 DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETV 296
V K + LK A V+L + P + V
Sbjct: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAV 1570
Score = 38.1 bits (87), Expect = 0.040
Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 12/126 (9%)
Query: 296 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355
V + F GLG S+ VG+ ++ ++ G G+L GD LL VN
Sbjct: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
Query: 356 YSLEEVTHEEAVAILK----NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 411
+L H++ V ILK + V + PTT D DI + P ++
Sbjct: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEF 664
Query: 412 SGNNGT 417
G++ T
Sbjct: 665 IGSSET 670
Score = 35.0 bits (79), Expect = 0.34
Identities = 25/81 (30%), Positives = 37/81 (45%)
Query: 529 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 588
L K GLG I + G+ + + G A G L+ GDQIL+V+ + G E+
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
Query: 589 AAALKGAGQTVTIIAQYQPED 609
+ LK A TV + + D
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPD 1566
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 138 bits (347), Expect = 3e-32
Identities = 165/696 (23%), Positives = 267/696 (38%), Gaps = 154/696 (22%)
Query: 327 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 386
I+V +I A +DG +Q GD +L +N E ++ +A +++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 387 IYMTDPYGPPDITHSYS------------------------PPMENHLLSGN-------- 414
+ + D HS + PP + S +
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDH 325
Query: 415 ---------NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDK--P 463
NG+L + PG S KH DD+T P+ V + +K P
Sbjct: 326 SRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHA---DDHT--PKTVEEVTVERNEKQTP 380
Query: 464 ASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 523
+ P K L + P + +S H +PSM L
Sbjct: 381 SLPE-------PKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKL--------- 424
Query: 524 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 583
V KG + +G + GG D GIFV+ +L PA G L+ GDQIL VN +D
Sbjct: 425 ---VKFRKGDS-VGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
Query: 584 SHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQ 640
E+A L G+ VTI+AQ + + Y R E+ + D
Sbjct: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD--------------------- 517
Query: 641 KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEE 697
S Y+R F+Y+K GLSF G++ V++ + W A R+ E
Sbjct: 518 --SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE 570
Query: 698 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSE 757
G+IP+K R E+ L +V++ + F + F +N +S
Sbjct: 571 RGIIPNKNRAEQ-----LASVQYTLPKTAGGDRADF-------WRFRGLRSSKRNLRKSR 618
Query: 758 QETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 817
++ S + + +YE V +E + RPV I GP+ D + L E PD +
Sbjct: 619 EDLS--AQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIA 672
Query: 818 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 877
RD D R + + +++ + ++ KH
Sbjct: 673 KSEPRDAGTDQRSSGII----------------------------RLHTIKQIIDQDKHA 704
Query: 878 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQE 934
+LDV+ NA+ RL AQ YPI +F+ P S + + M RL E A+K Y+R+ KL +
Sbjct: 705 LLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKN 764
Query: 935 FGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 969
FT + +++ D Y K I++Q +W+
Sbjct: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 62.0 bits (149), Expect = 3e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 199 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 256
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
Query: 257 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
Score = 51.2 bits (121), Expect = 5e-06
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 5/92 (5%)
Query: 307 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 365
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 366 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 397
AV L+ + + + + + + + P PD
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD 120
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 523 EPRKVVLHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 574
E V LH+ G G I GG D GE I +S +L GGPA+ G+LQ D++
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
Query: 575 VNGIDLRGASHEQAAAALKGAGQTVTI 601
VNG+ + H A L+ +G+ I
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKI 104
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 208 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 267
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 268 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 298
+AV L + G V + ++++ + +VE
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 292 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 351
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
Query: 352 MVNNYSLEEVTHEEAVAIL 370
VNN + EEAV L
Sbjct: 469 RVNNVDFTNIIREEAVLFL 487
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 138 bits (347), Expect = 3e-32
Identities = 165/696 (23%), Positives = 267/696 (38%), Gaps = 154/696 (22%)
Query: 327 IYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 386
I+V +I A +DG +Q GD +L +N E ++ +A +++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 387 IYMTDPYGPPDITHSYS------------------------PPMENHLLSGN-------- 414
+ + D HS + PP + S +
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDH 325
Query: 415 ---------NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDK--P 463
NG+L + PG S KH DD+T P+ V + +K P
Sbjct: 326 SRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHA---DDHT--PKTVEEVTVERNEKQTP 380
Query: 464 ASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 523
+ P K L + P + +S H +PSM L
Sbjct: 381 SLPE-------PKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKL--------- 424
Query: 524 PRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGA 583
V KG + +G + GG D GIFV+ +L PA G L+ GDQIL VN +D
Sbjct: 425 ---VKFRKGDS-VGLRLAGGND-VGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNI 478
Query: 584 SHEQAAAALKGA--GQTVTIIAQYQPEDYARF-EAKIHDLREQMMNHSMSSGSGSLRTNQ 640
E+A L G+ VTI+AQ + + Y R E+ + D
Sbjct: 479 IREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD--------------------- 517
Query: 641 KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW---WQARRVMLEGDSEE 697
S Y+R F+Y+K GLSF G++ V++ + W A R+ E
Sbjct: 518 --SFYIRTHFEYEKESP-----YGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE 570
Query: 698 MGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSE 757
G+IP+K R E+ L +V++ + F + F +N +S
Sbjct: 571 RGIIPNKNRAEQ-----LASVQYTLPKTAGGDRADF-------WRFRGLRSSKRNLRKSR 618
Query: 758 QETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHT 817
++ S + + +YE V +E + RPV I GP+ D + L E PD +
Sbjct: 619 EDLS--AQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIA 672
Query: 818 TRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHC 877
RD D R + + +++ + ++ KH
Sbjct: 673 KSEPRDAGTDQRSSGII----------------------------RLHTIKQIIDQDKHA 704
Query: 878 ILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEE---QAKKTYDRAIKLEQE 934
+LDV+ NA+ RL AQ YPI +F+ P S + + M RL E A+K Y+R+ KL +
Sbjct: 705 LLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKN 764
Query: 935 FGEYFTAIVQGDTLED-IYNQCKLVIEEQSGPFIWI 969
FT + +++ D Y K I++Q +W+
Sbjct: 765 NHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 62.0 bits (149), Expect = 3e-09
Identities = 33/96 (34%), Positives = 57/96 (59%), Gaps = 4/96 (4%)
Query: 199 YEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVNDCIL 256
+E +TL R G G +I+GG DNPH + I I+ ++ GG A +G+L+ ND +
Sbjct: 19 WEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVA 76
Query: 257 RVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
VN V + V H+ AV+ L+++G ++ +RR++ +
Sbjct: 77 MVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKV 112
Score = 51.2 bits (121), Expect = 5e-06
Identities = 30/92 (32%), Positives = 50/92 (54%), Gaps = 5/92 (5%)
Query: 307 GLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEE 365
G G +I+GG N H G+ SI ++ ++ GG A+ G+LQ DR+ MVN S++ V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAMVNGVSMDNVEHAF 90
Query: 366 AVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 397
AV L+ + + + + + + + P PD
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQI--PVSRPD 120
Score = 46.6 bits (109), Expect = 1e-04
Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 523 EPRKVVLHKG-STGLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 574
E V LH+ G G I GG D GE I +S +L GGPA+ G+LQ D++
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE--GQLQENDRVAM 77
Query: 575 VNGIDLRGASHEQAAAALKGAGQTVTI 601
VNG+ + H A L+ +G+ I
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKI 104
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/93 (30%), Positives = 47/93 (50%), Gaps = 10/93 (10%)
Query: 208 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 267
R +G +AGG +D GIF+ ++ AA++G L D ILRVN VD + +
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 268 HSKAVEALKE--AGSIVRLYVRRRRPILETVVE 298
+AV L + G V + ++++ + +VE
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 8/79 (10%)
Query: 292 ILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 351
IL +++ F+ +G +AGG D I+V +++ A K+G L+ GD++L
Sbjct: 417 ILRPSMKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQIL 468
Query: 352 MVNNYSLEEVTHEEAVAIL 370
VNN + EEAV L
Sbjct: 469 RVNNVDFTNIIREEAVLFL 487
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 137 bits (345), Expect = 5e-32
Identities = 166/677 (24%), Positives = 275/677 (40%), Gaps = 148/677 (21%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 381
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 382 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HML 440
+ T I + P + S S + + N +SP + H
Sbjct: 385 SQQTLINI------PSLNDSDSEIEDISEIESNRS---------------FSPEERRHQY 423
Query: 441 VDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSH---YHLGLLPDSEM 497
D DY +S+ KL ++P+S R +P + P+ ++P++
Sbjct: 424 SDYDY-------HSSSEKLKERPSS-REDTPSRLSRMGATPTPFKSTGDIAGTVVPETNK 475
Query: 498 TSHSQHSTATRQPSMTLQRAV-------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 550
Q QP + + ++ G K+V K +G + GG D GIF
Sbjct: 476 EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIF 534
Query: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPE 608
V+ I G A+ G LQ GDQIL VN D RG E A L G+ VTI+AQ + +
Sbjct: 535 VAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRAD 593
Query: 609 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFK 668
Y ++ G G S ++R+ F+ +K Q L+F
Sbjct: 594 VYRDI---------------LACGRGD-------SFFIRSHFECEKETP-----QSLAFT 626
Query: 669 YGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPG 725
G++ V++ D W A R+ G+ E G+IP+K R E+ + NA+
Sbjct: 627 RGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQR- 676
Query: 726 VIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---------SYEP 776
D+ G D F++ + Q + + +EDL +YE
Sbjct: 677 --DNAGDRAD-------------FWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYER 721
Query: 777 VTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVIS 836
V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 722 VLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------- 762
Query: 837 REQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYP 896
KD K + N +VR + E+ KH +LDV+ A+ L Q +P
Sbjct: 763 -----KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFP 808
Query: 897 IAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDI-Y 952
I IF P S + + M +RL + + ++K +D+A KL++ FTA + ++ D +
Sbjct: 809 IVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWF 868
Query: 953 NQCKLVIEEQSGPFIWI 969
K I+ Q G +W+
Sbjct: 869 GSLKDTIQHQQGEAVWV 885
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 196 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 253
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
Query: 254 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
Score = 57.4 bits (137), Expect = 6e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 306 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 364
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 365 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 398
AV L+ + +V + V +P + + P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 523 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 574
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
Query: 575 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 604
VNG + H A L+ +G+ I+ +
Sbjct: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 33.9 bits (76), Expect = 0.76
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 264 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 297
+ AV L E G +V + + R + ++
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
Score = 30.4 bits (67), Expect = 8.4
Identities = 16/57 (28%), Positives = 31/57 (54%)
Query: 232 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 288
IF+ ++ G A +DG L D IL++N +S + A + ++++ ++L V R
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 137 bits (345), Expect = 5e-32
Identities = 166/677 (24%), Positives = 275/677 (40%), Gaps = 148/677 (21%)
Query: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTS---EVVYLKV 381
+ I+V ++ G A KDG L GD +L +N E ++ +A +++ + ++V L+
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 382 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK-HML 440
+ T I + P + S S + + N +SP + H
Sbjct: 385 SQQTLINI------PSLNDSDSEIEDISEIESNRS---------------FSPEERRHQY 423
Query: 441 VDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSH---YHLGLLPDSEM 497
D DY +S+ KL ++P+S R +P + P+ ++P++
Sbjct: 424 SDYDY-------HSSSEKLKERPSS-REDTPSRLSRMGATPTPFKSTGDIAGTVVPETNK 475
Query: 498 TSHSQHSTATRQPSMTLQRAV-------SLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIF 550
Q QP + + ++ G K+V K +G + GG D GIF
Sbjct: 476 EPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIF 534
Query: 551 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQYQPE 608
V+ I G A+ G LQ GDQIL VN D RG E A L G+ VTI+AQ + +
Sbjct: 535 VAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRAD 593
Query: 609 DYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFK 668
Y ++ G G S ++R+ F+ +K Q L+F
Sbjct: 594 VYRDI---------------LACGRGD-------SFFIRSHFECEKETP-----QSLAFT 626
Query: 669 YGDILHVINASDDEW---WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPG 725
G++ V++ D W A R+ G+ E G+IP+K R E+ + NA+
Sbjct: 627 RGEVFRVVDTLYDGKLGNWLAVRI---GNELEKGLIPNKSRAEQMASVQ------NAQR- 676
Query: 726 VIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLIL---------SYEP 776
D+ G D F++ + Q + + +EDL +YE
Sbjct: 677 --DNAGDRAD-------------FWRMRGQRSGVKKNLRKSREDLTAVVSVSTKFPAYER 721
Query: 777 VTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVIS 836
V +E + RPV++ GP+ D + L +E PD F + T P
Sbjct: 722 VLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEP---------------- 762
Query: 837 REQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYP 896
KD K + N +VR + E+ KH +LDV+ A+ L Q +P
Sbjct: 763 -----KDAGSEKSTGVVRLN---------TVRQIIEQDKHALLDVTPKAVDLLNYTQWFP 808
Query: 897 IAIFIKPRSLEPLMEMNKRL---TEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDI-Y 952
I IF P S + + M +RL + + ++K +D+A KL++ FTA + ++ D +
Sbjct: 809 IVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWF 868
Query: 953 NQCKLVIEEQSGPFIWI 969
K I+ Q G +W+
Sbjct: 869 GSLKDTIQHQQGEAVWV 885
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 196 EIEYEFEEITLERGNS-GLGFSIAGGTDNPHI-GDDPGIFITKIIPGGAAAEDGRLRVND 253
E+ +E +TL++ + G G +++GG DNPH + I I+ ++PGG A DG L+ ND
Sbjct: 26 ELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQEND 83
Query: 254 CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPI 292
++ VN + +V HS AV+ L+++G + + V+R R +
Sbjct: 84 RVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKV 122
Score = 57.4 bits (137), Expect = 6e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 306 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHE 364
+G G +++GG N H G+ SI ++ ++ GG A DG LQ DR++MVN +E+V H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 365 EAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDI 398
AV L+ + +V + V +P + + P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 45.4 bits (106), Expect = 3e-04
Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 10/90 (11%)
Query: 523 EPRKVVLHKGST-GLGFNIVGGED------GE-GIFVSFILAGGPADLSGELQRGDQILS 574
E V L K S G G + GG D GE I +S +L GGPAD G LQ D+++
Sbjct: 30 EQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQENDRVVM 87
Query: 575 VNGIDLRGASHEQAAAALKGAGQTVTIIAQ 604
VNG + H A L+ +G+ I+ +
Sbjct: 88 VNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 33.9 bits (76), Expect = 0.76
Identities = 28/96 (29%), Positives = 48/96 (50%), Gaps = 11/96 (11%)
Query: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
+ ++G+S +G +AGG +D GIF+ I G +A ++G L+ D IL+VN D
Sbjct: 513 VRFKKGDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDF 563
Query: 264 SEVSHSKAVEALKE--AGSIVRLYVRRRRPILETVV 297
+ AV L E G +V + + R + ++
Sbjct: 564 RGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDIL 599
Score = 30.4 bits (67), Expect = 8.4
Identities = 16/57 (28%), Positives = 31/57 (54%)
Query: 232 IFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 288
IF+ ++ G A +DG L D IL++N +S + A + ++++ ++L V R
Sbjct: 327 IFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 120 bits (300), Expect = 8e-27
Identities = 114/437 (26%), Positives = 185/437 (42%), Gaps = 85/437 (19%)
Query: 202 EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 261
EE+ L SGLGF I GG + G+ + I+PGG A DGRL+ D IL++
Sbjct: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
Query: 262 DVSEVSHSKAVEALKEAGSIVRLYVRRR-------RPILETVVEIKL----FKGP----- 305
+V ++ + + L+ G+ VR+ V R P + + L KGP
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
Query: 306 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 351
+ LG I G VG H + IYV II G AA +G +QV D+++
Sbjct: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
Query: 352 MVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 411
V+ +++ + + V +L+N +VV+L + + T T P PP + P++ L
Sbjct: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
Query: 412 SGNNGTLEYKTSLPPISPGRYSPIPKHM--LVDDDYTRPPEPVYSTVNKLCDKPASPRHY 469
G +E +T++ G I + + L +D+ + KL P SP +
Sbjct: 480 F-LTGAVETETNV----DGEDEEIKERIDTLKNDN--------IQALEKLEKVPDSPENE 526
Query: 470 SPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRK--- 526
S + L PD E+ TL ++ + E +K
Sbjct: 527 LK-------------SRWENLLGPDYEVM------------VATLDTQIADDAELQKYSK 561
Query: 527 -VVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASH 585
+ +H G+ + G ++S I++GGP D G LQ D++L VNG+ L G S
Sbjct: 562 LLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSR 617
Query: 586 EQAAAALKGAGQTVTII 602
+A + LK T++
Sbjct: 618 REAVSFLKEVPPPFTLV 634
Score = 108 bits (271), Expect = 2e-23
Identities = 77/220 (35%), Positives = 106/220 (48%), Gaps = 31/220 (14%)
Query: 170 SPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDD 229
+PL PA T P V G E+ E + +G SGLG SI GG D P
Sbjct: 1419 APLSVDPA----------TCPIVPGQEMIIE-----ISKGRSGLGLSIVGGKDTPL---- 1459
Query: 230 PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 289
I I ++ GAAA DGRL D IL VN VD+ SH +A+ AL++ VRL V R
Sbjct: 1460 NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRD 1519
Query: 290 RPILETVVEIKLF------KGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 343
+++F K +GLG SI G + ++++ I+ GGAA DGR
Sbjct: 1520 EAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK------RNGSGVFISDIVKGGAADLDGR 1573
Query: 344 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
L GD++L VN + + E ILK +V L++G+
Sbjct: 1574 LIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR 1613
Score = 103 bits (258), Expect = 6e-22
Identities = 117/412 (28%), Positives = 169/412 (41%), Gaps = 60/412 (14%)
Query: 200 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
E I LE+ +GLG S+AG D + IF+ I P G AA DGR+R+ D +L +N
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMS----IFVVGINPEGPAAADGRMRIGDELLEIN 1291
Query: 260 EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQ 319
+ SH A +K A S V+L R + + + F P SI G +
Sbjct: 1292 NQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMA-VTPFPVPSSSPSSIEDQSGTE 1350
Query: 320 HIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 379
I ++++DG ++VG + L E + + AV+ +K
Sbjct: 1351 PI---------------SSEEDGSVEVGIKQLP------ESESFKLAVSQMKQQKY---- 1385
Query: 380 KVGKPTTIYMTD---PYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 436
PT + + P P HS + G L + PI PG+
Sbjct: 1386 ----PTKVSFSSQEIPLAPASSYHSTDADFTGY--GGFQAPLSVDPATCPIVPGQ----- 1434
Query: 437 KHMLVDDDYTRPPEPVYSTVNKLCDKPASPRH--YSPVECDKSFLLSAPYSHYHLGLLPD 494
M+++ R + K A H Y + L A + + D
Sbjct: 1435 -EMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV-D 1492
Query: 495 SEMTSHSQHSTATRQPSMTLQRAV-----------SLEGEPRKVVLHKGSTGLGFNIVGG 543
+SH + TA RQ ++ V +LE P + K GLG +IVG
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQ-KKAGRGLGLSIVGK 1551
Query: 544 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
+G G+F+S I+ GG ADL G L +GDQILSVNG D+R AS E A LK A
Sbjct: 1552 RNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCA 1603
Score = 99.0 bits (245), Expect = 2e-20
Identities = 93/325 (28%), Positives = 141/325 (43%), Gaps = 41/325 (12%)
Query: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
I+L K GLG S+AG + SI+V I G A DGR+++GD LL +NN L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 359 EEVTHEEAVAILKNTS---EVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 415
+H+ A AI+K ++V+++ P+ P S +
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP---------------SSSP 1340
Query: 416 GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHY-SPVEC 474
++E ++ PIS V+ + PE S KL + Y + V
Sbjct: 1341 SSIEDQSGTEPISSEEDGS------VEVGIKQLPE---SESFKLAVSQMKQQKYPTKVSF 1391
Query: 475 DKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGST 534
+ AP S YH D++ T + T + G+ + + KG +
Sbjct: 1392 SSQEIPLAPASSYHS---TDADFTGYGGFQAPLSVDPATCP---IVPGQEMIIEISKGRS 1445
Query: 535 GLGFNIVGGEDG--EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAAL 592
GLG +IVGG+D I + + G A G L GDQIL VNG+DLR +SHE+A AL
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Query: 593 KGAGQTVTIIAQYQPEDYARFEAKI 617
+ Q V ++ Y+ E + R E +
Sbjct: 1506 RQTPQKVRLVV-YRDEAHYRDEENL 1529
Score = 88.2 bits (217), Expect = 3e-17
Identities = 69/227 (30%), Positives = 108/227 (47%), Gaps = 41/227 (18%)
Query: 194 GTEIEYEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVN 252
G +IEY I +ER ++G LGFS+ + ++G IF+ + PG A D RL+ N
Sbjct: 129 GRQIEY----IDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKEN 182
Query: 253 DCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRRR--------------RPILETVV 297
D IL +N + + +SH +A+ L++ +RL V R + ETV
Sbjct: 183 DQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC 242
Query: 298 -----EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLM 352
E++L GLGF I GG + + V I+ GG A +DGRLQ GD +L
Sbjct: 243 WGHVEEVELINDGSGLGFGIVGGK-------TSGVVVRTIVPGGLADRDGRLQTGDHILK 295
Query: 353 VNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDIT 399
+ +++ +T E+ +L+N V + V + DP G +T
Sbjct: 296 IGGTNVQGMTSEQVAQVLRNCGNSVRMLVAR-------DPAGDISVT 335
Score = 84.7 bits (208), Expect = 4e-16
Identities = 85/331 (25%), Positives = 139/331 (41%), Gaps = 38/331 (11%)
Query: 291 PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350
P E ++EI KG GLG SI GG N+I + ++ + GAA +DGRL GD++
Sbjct: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
Query: 351 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDP---YGPPDITHSYSPPME 407
L VN L +HEEA+ L+ T + V L V + Y + P D+ +
Sbjct: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLG 1545
Query: 408 NHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD--------DYTRPPEPVYSTVNKL 459
++ NG+ + + I G + + ++ D D + +T+ K
Sbjct: 1546 LSIVGKRNGSGVF---ISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
Query: 460 CD----------KPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 509
+ S + + +S H P + + Q+ T++
Sbjct: 1603 AQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP---VITGLQNLVGTKR 1659
Query: 510 PSMTLQRAVSLEGEPRKVVLHKG-STGLGFNIVGGEDGE----GIFVSFILAGGPADLSG 564
S Q+ + EPR V +++ S LG +I GG +F++ I A G A +
Sbjct: 1660 VSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
Query: 565 ELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
+L+ GD+I+S+NG L G SH LK A
Sbjct: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 73.2 bits (178), Expect = 1e-12
Identities = 66/235 (28%), Positives = 96/235 (40%), Gaps = 62/235 (26%)
Query: 207 ERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEV 266
++ GLG SI G + G+FI+ I+ GGAA DGRL D IL VN D+
Sbjct: 1538 KKAGRGLGLSIVGKRNGS------GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
Query: 267 SHSKAVEALKEAGSIVRLYVRRRR------------------------------PI---L 293
S LK A +V+L + R R P+ L
Sbjct: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
Query: 294 ETVVEIKLFKGPK---------------------GLGFSIAGGVGNQHIPGDNSIYVTKI 332
+ +V K P LG SIAGG G+ GD +++ I
Sbjct: 1652 QNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPL--GDIPVFIAMI 1709
Query: 333 IDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 387
G A + +L+VGDR++ +N L+ ++H + V +LKN + L+V T I
Sbjct: 1710 QASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNI 1764
Score = 68.2 bits (165), Expect = 4e-11
Identities = 40/108 (37%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 500 HSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGP 559
H++ ST++ TL V G +V L +GLGF IVGG+ G+ V I+ GG
Sbjct: 223 HTKSSTSSSLNDTTLPETVCW-GHVEEVELINDGSGLGFGIVGGKTS-GVVVRTIVPGGL 280
Query: 560 ADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 607
AD G LQ GD IL + G +++G + EQ A L+ G +V ++ P
Sbjct: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 64.7 bits (156), Expect = 4e-10
Identities = 37/94 (39%), Positives = 53/94 (56%), Gaps = 11/94 (11%)
Query: 522 GEPRKV-VLHKGSTGLGFNIVGG----------EDGEGIFVSFILAGGPADLSGELQRGD 570
G PR V + + + LG +IVGG E+ +GIF+ +L PA + L+ GD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
Query: 571 QILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 604
+IL V+G+DL+ ASH +A A+K AG V I Q
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 62.4 bits (150), Expect = 2e-09
Identities = 36/122 (29%), Positives = 62/122 (50%)
Query: 169 ISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD 228
IS +PA + V T+ + + + + + + + LG I G H G+
Sbjct: 332 ISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
Query: 229 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 288
GI++ IIPG AA +G ++VND I+ V+ V++ ++ VE L+ AG +V L + R
Sbjct: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVR 451
Query: 289 RR 290
R+
Sbjct: 452 RK 453
Score = 54.3 bits (129), Expect = 5e-07
Identities = 55/192 (28%), Positives = 80/192 (41%), Gaps = 41/192 (21%)
Query: 233 FITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR--- 289
+I+ I+ GG G L+ D +L VN + + S +AV LKE L RR
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 290 ------------RPILETVVE------------------------IKLFKGPKGLGFSIA 313
+ ET V+ ++L K KGLGFSI
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
Query: 314 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 373
+ P + I + ++ G A++ G L GDRL+ VN Y L+ + EAV ILK
Sbjct: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Query: 374 SE-VVYLKVGKP 384
+V+L + KP
Sbjct: 761 PPGLVHLGICKP 772
Score = 53.9 bits (128), Expect = 7e-07
Identities = 68/315 (21%), Positives = 113/315 (35%), Gaps = 77/315 (24%)
Query: 299 IKLFKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350
+++F+ P LG SI GG + + G I++ ++++ A K L+ GD++
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 351 LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHL 410
L V+ L+ +H EAV +KN G P + P + +
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKN--------AGNPVVFIVQSLSSTPRVIPNVHNKANKIT 1177
Query: 411 LSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPA---SPR 467
+ N T E K +P P + + DD E T K+ + A
Sbjct: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL 1237
Query: 468 HYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV 527
H +E DK+ L +SL G
Sbjct: 1238 HIIELEKDKNGL-------------------------------------GLSLAG----- 1255
Query: 528 VLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 587
+K + + +VG I GPA G ++ GD++L +N L G SH+
Sbjct: 1256 --NKDRSRMSIFVVG-----------INPEGPAAADGRMRIGDELLEINNQILYGRSHQN 1302
Query: 588 AAAALKGAGQTVTII 602
A+A +K A V ++
Sbjct: 1303 ASAIIKTAPSKVKLV 1317
Score = 53.1 bits (126), Expect = 1e-06
Identities = 45/128 (35%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 166 QSHISPLKASPAPIIVNTDTL-------DTIPYVNGTEIEYEFEEITLERGNSGLGFSIA 218
QS S S AP+I L D +GT++E EI E ++ LG SIA
Sbjct: 1634 QSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDA-LGISIA 1692
Query: 219 GGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
GG +P +GD P +FI I G AA +L+V D I+ +N + +SH+ V LK A
Sbjct: 1693 GGRGSP-LGDIP-VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Query: 279 GSIVRLYV 286
+ L V
Sbjct: 1751 YGRIILQV 1758
Score = 51.6 bits (122), Expect = 4e-06
Identities = 73/309 (23%), Positives = 124/309 (40%), Gaps = 38/309 (12%)
Query: 14 DIQEFYEVTLLNSQKSCEQKIEEANQVLQKWEKTSLLAPCHDRLQKSSELTDCSGSKENA 73
++ EF L + E ++E ++ Q + L P +Q+++ + +
Sbjct: 852 EMHEFLTPRLQEMDEEREMLVDEEYELYQDPSPSMELYPL-SHIQEATPVPSVNELHFGT 910
Query: 74 SCIEQNKENQSFENETDETT----TQNQGRCPA----QNCSVEAPAWMPVHHCTKYRYQD 125
+ N+ ++S E T T Q G CP +N +E+ +P + +
Sbjct: 911 QWLHDNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRF 970
Query: 126 EDAPHDHSLPR-------LTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAP 178
+D + +SL + + ++V+GP L+ + ++Q L H + S A
Sbjct: 971 DDLENLNSLAKTSLDLGMIPNDVQGPSLL-IDLPVVAQRREQEDLPLYQHQATRVISKAS 1029
Query: 179 IIVN-------TDTLDTIPYVNGTEIEY---------EFEEITLERGNSGLGFSIAGGTD 222
TDT + G E EI E N LG SI GG
Sbjct: 1030 AYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREP-NVSLGISIVGGQT 1088
Query: 223 ---NPHIGDD-PGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 278
G++ GIFI +++ A + L+ D IL V+ VD+ SHS+AVEA+K A
Sbjct: 1089 VIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA 1148
Query: 279 GSIVRLYVR 287
G+ V V+
Sbjct: 1149 GNPVVFIVQ 1157
Score = 38.5 bits (88), Expect = 0.031
Identities = 26/78 (33%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 535 GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RGASHEQAA 589
GLGF++V IFV + G AD L+ DQIL++N L + SH+QA
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 590 AALKGAGQTVTIIAQYQP 607
A L+ ++ +I +P
Sbjct: 204 ALLQQTTGSLRLIVAREP 221
Score = 38.5 bits (88), Expect = 0.031
Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 23/126 (18%)
Query: 523 EPRKVVLHKGSTGLGFNIVGGEDG-----EGIFVSFILAGGPADLSGELQRGDQILSVNG 577
E + V L K GLGF+I+ +D I + ++A G A+ SG L GD+++SVN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 578 IDLRGASHEQAAAALKGA------------------GQTVTIIAQYQPEDYARFEAKIHD 619
L S +A LK ++ I+ ED F IHD
Sbjct: 743 YCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHD 802
Query: 620 LREQMM 625
+ ++
Sbjct: 803 INSSLI 808
Score = 34.3 bits (77), Expect = 0.58
Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 200 EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259
E + + L + GLGFSI D P I I ++ G A G L D ++ VN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 260 EVDVSEVSHSKAVEALK 276
E + S ++AVE LK
Sbjct: 742 EYCLDNTSLAEAVEILK 758
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,995,910
Number of Sequences: 37866
Number of extensions: 1937194
Number of successful extensions: 5270
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 3968
Number of HSP's gapped (non-prelim): 1056
length of query: 975
length of database: 18,247,518
effective HSP length: 112
effective length of query: 863
effective length of database: 14,006,526
effective search space: 12087631938
effective search space used: 12087631938
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.