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Search of human proteins with 21704279
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
(1200 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 2684 0.0
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 2665 0.0
gi|4557679 jagged 1 precursor [Homo sapiens] 1368 0.0
gi|148833508 notch1 preproprotein [Homo sapiens] 492 e-138
gi|110735443 delta-like 1 [Homo sapiens] 489 e-138
gi|24041035 notch 2 preproprotein [Homo sapiens] 472 e-133
gi|134244285 Notch homolog 3 [Homo sapiens] 468 e-131
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 465 e-130
gi|55770876 notch4 preproprotein [Homo sapiens] 441 e-123
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 377 e-104
gi|122937283 6720455I24Rik homolog [Homo sapiens] 364 e-100
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 300 7e-81
gi|112420992 crumbs homolog 2 [Homo sapiens] 300 7e-81
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 240 7e-63
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 240 7e-63
gi|66346695 fibrillin 2 precursor [Homo sapiens] 233 6e-61
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 232 2e-60
gi|153946395 tenascin C precursor [Homo sapiens] 228 3e-59
gi|110347437 latent transforming growth factor beta binding prot... 225 2e-58
gi|110347412 latent transforming growth factor beta binding prot... 225 2e-58
gi|110347431 latent transforming growth factor beta binding prot... 225 2e-58
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 225 2e-58
gi|148886654 polydom [Homo sapiens] 223 7e-58
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 221 4e-57
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 219 1e-56
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 214 4e-55
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 214 4e-55
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens] 212 1e-54
gi|11321571 slit homolog 3 [Homo sapiens] 209 1e-53
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 209 1e-53
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 2684 bits (6957), Expect = 0.0
Identities = 1200/1200 (100%), Positives = 1200/1200 (100%)
Query: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
Sbjct: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
Query: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
Sbjct: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
Query: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS
Sbjct: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
Query: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC
Sbjct: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
Query: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG 300
KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG
Sbjct: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG 300
Query: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG
Sbjct: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
Query: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC
Sbjct: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
Query: 421 QLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 480
QLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD
Sbjct: 421 QLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 480
Query: 481 GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC 540
GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC
Sbjct: 481 GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC 540
Query: 541 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 600
PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID
Sbjct: 541 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 600
Query: 601 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYC 660
DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYC
Sbjct: 601 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYC 660
Query: 661 ACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN 720
ACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN
Sbjct: 661 ACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN 720
Query: 721 PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPG 780
PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPG
Sbjct: 721 PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPG 780
Query: 781 FAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP 840
FAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP
Sbjct: 781 FAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP 840
Query: 841 FPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQC 900
FPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQC
Sbjct: 841 FPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQC 900
Query: 901 LRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSL 960
LRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSL
Sbjct: 901 LRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSL 960
Query: 961 PATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGN 1020
PATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGN
Sbjct: 961 PATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGN 1020
Query: 1021 SSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRL 1080
SSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRL
Sbjct: 1021 SSLLLAVTEVKVETVVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRL 1080
Query: 1081 PREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDE 1140
PREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDE
Sbjct: 1081 PREESANNQWAPLNPIRNPIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDE 1140
Query: 1141 EDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1200
EDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
Sbjct: 1141 EDEDLGRGEEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1200
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 2665 bits (6908), Expect = 0.0
Identities = 1200/1238 (96%), Positives = 1200/1238 (96%), Gaps = 38/1238 (3%)
Query: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
Sbjct: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
Query: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
Sbjct: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
Query: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS
Sbjct: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
Query: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC
Sbjct: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
Query: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG 300
KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG
Sbjct: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG 300
Query: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG
Sbjct: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
Query: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC
Sbjct: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
Query: 421 QLD--------------------------------------VNDCRGQCQHGGTCKDLVN 442
QLD VNDCRGQCQHGGTCKDLVN
Sbjct: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN 480
Query: 443 GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC 502
GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC
Sbjct: 481 GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC 540
Query: 503 EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 562
EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT
Sbjct: 541 EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 600
Query: 563 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 622
AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC
Sbjct: 601 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 660
Query: 623 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 682
FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT
Sbjct: 661 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 720
Query: 683 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 742
CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG
Sbjct: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
Query: 743 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 802
WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA
Sbjct: 781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 840
Query: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 862
TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD
Sbjct: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 900
Query: 863 CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL 922
CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL
Sbjct: 901 CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL 960
Query: 923 PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG 982
PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG
Sbjct: 961 PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG 1020
Query: 983 ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST 1042
ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST
Sbjct: 1021 ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST 1080
Query: 1043 GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER 1102
GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER
Sbjct: 1081 GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER 1140
Query: 1103 PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK 1162
PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK
Sbjct: 1141 PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK 1200
Query: 1163 FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1200
FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
Sbjct: 1201 FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1238
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 1368 bits (3542), Expect = 0.0
Identities = 638/1251 (50%), Positives = 814/1251 (65%), Gaps = 95/1251 (7%)
Query: 2 RAQGRGRLPRRLLLLL--ALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRA 59
R +GR P LLL L AL + G FEL++ +++NVNGEL +G CC G R
Sbjct: 5 RTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGG-ARNPGD 63
Query: 60 GGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARA 119
C DECDTY +VCLKEYQ++VT GPCS+G G+TPV+GGN+F L A DR R
Sbjct: 64 RKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLK-ASRGNDRNR--- 119
Query: 120 RAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWK 179
+V+PF FAWPRS+TL+VEAWD NDT + + IE+ SH+GMINP +W+
Sbjct: 120 ----------IVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSI-IEKASHSGMINPSRQWQ 168
Query: 180 SLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKE 239
+L + VAH E QIRV CD+ YY CNKFCRPR+DFFGHY CDQ GNK CM+GWMG E
Sbjct: 169 TLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPE 228
Query: 240 CKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNW 299
C A+C+QGC+ HG C +PG+CRC YGWQG +CD+C+P+PGCVHG C EPWQC CETNW
Sbjct: 229 CNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNW 288
Query: 300 GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANG 359
GG LCDKDLNYCG+H PC NGGTC N PD+Y+C+CP+GYSG NCE AEHAC S+PC N
Sbjct: 289 GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNR 348
Query: 360 GSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGAT 419
GSC E GFEC C GW+GPTC+ +ID+C+ N C+ GGTC D V+GF+C+CP QW G T
Sbjct: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKT 408
Query: 420 CQLD--------------------------------------VNDCRGQCQHGGTCKDLV 441
CQLD +NDC GQCQ+ +C+DLV
Sbjct: 409 CQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLV 468
Query: 442 NGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 501
NGY+C+CP G+ G HCE + DECAS+PC +GG C++ + F C CP GFSG LC++D+D
Sbjct: 469 NGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY 528
Query: 502 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC----GSDAGP 557
CEP+PC+NGA+CYN DY+C CP+D+ GKNCS ++ C C VID C S+ P
Sbjct: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
Query: 558 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEV 617
+S VCGPHG+C SQ GG F+C C+ GFTGTYCHENI+DC PCRNGGTCID V
Sbjct: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
Query: 618 DAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ 677
++++C C GWEG C+TN NDC +PCH+ G C DLVNDFYC C +GWKGKTCHSR+ Q
Sbjct: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
Query: 678 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 737
CD TC+NGGTCYD GD F+C CP GW+G+TC +A+NSSCLPNPC NGGTCV +G SF+C
Sbjct: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTC 768
Query: 738 ICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP 797
+C++GWEG C NTNDC+P PCYN G CVDG NW+RCECAPGFAGPDCRINI+ECQSSP
Sbjct: 769 VCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP 828
Query: 798 CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 857
CA+GATCVDEINGYRC CPPG +G +CQEV GR C + G+ P G+ W +DCN+C+CL
Sbjct: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQEV--SGRPCITMGSVIPDGAKWDDDCNTCQCL 886
Query: 858 DGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAE--E 915
+GR CSKVWCG +PCLL ++CP GQ C+ QC PC GEC + +
Sbjct: 887 NGRIACSKVWCGPRPCLL----HKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQ 942
Query: 916 PPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLL 975
P T C S + D NCA +T FN++ + G T ICS +R+L + V+ + + +
Sbjct: 943 PVKTKCTSDSYYQD-NCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIA 1001
Query: 976 CDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQR-GNSSLLLAVTEVKVET 1034
C+ + S + + VA+S RD D + I+ I+ +++R GNSSL+ AV EV+V+
Sbjct: 1002 CEPSPSANNEIHVAISAEDIRD--DGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQR 1059
Query: 1035 VVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWW-TRKRRKERERSRLPREE-SANNQWAP 1092
+ T LVP+L +V W+ C+V +W RKRRK + E+ + NN
Sbjct: 1060 RPL-KNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQ 1118
Query: 1093 LNPIRNPIERPGGH----KDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRG 1148
LN I+NPIE+ G + KD Y+ KN R ++ V ED+ D+ +
Sbjct: 1119 LNQIKNPIEKHGANTVPIKD--YENKNSKMSKIRTH--------NSEVEEDDMDKHQQKA 1168
Query: 1149 EEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNR---AVRSINEARY 1196
A + + K P +P + +W + K DNR + +S+N Y
Sbjct: 1169 RFAKQPAYTLVDRE-EKPPNGTPTKHPNWTN--KQDNRDLESAQSLNRMEY 1216
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 492 bits (1266), Expect = e-138
Identities = 263/745 (35%), Positives = 364/745 (48%), Gaps = 96/745 (12%)
Query: 211 CRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGCTVPG----ECRC 264
CRP D + C AC+ G+ G+ C+E + C G N +GG V G CRC
Sbjct: 233 CRPTGDVT--HEC------ACLPGFTGQNCEENIDDC-PGNNCKNGGACVDGVNTYNCRC 283
Query: 265 SYGWQGRFC----DECVPYPGCVH--GSCVEP---WQCNCETNWGGLLCDKDLNYCGSHH 315
W G++C DEC P G+C + C C W G C ++++ C S
Sbjct: 284 PPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCAS-A 342
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE--CHC 373
C +G TC + Y C CP G +G C AC SNPC G +C P + C C
Sbjct: 343 ACFHGATCHDRVASFY-CECPHGRTGLLCH-LNDACISNPCNEGSNCDTNPVNGKAICTC 400
Query: 374 PSGWSGPTCALDIDECA--SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQ 430
PSG++GP C+ D+DEC+ +NPC G C++ + FEC C + + G C++DVN+C
Sbjct: 401 PSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNP 460
Query: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 490
CQ+ TC D + +QC+C G+ G HCE+ DECASSPC G C D + F C CP GF
Sbjct: 461 CQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGF 520
Query: 491 SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDG 550
+G LC+ DVD C +PC+NGA+C + Y C C + + G +C V + C
Sbjct: 521 TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDEC---------- 570
Query: 551 CGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNG 610
D P G+ GV F+C+C G+TG +C NI++C QPCR+G
Sbjct: 571 ---DPDPCHYGSCKDGV------------ATFTCLCRPGYTGHHCETNINECSSQPCRHG 615
Query: 611 GTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKT 670
GTC D +A+ CFC G G C+ N +DC PC S G C D ++ + CAC+ G+ G
Sbjct: 616 GTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDS-GTCLDKIDGYECACEPGYTGSM 674
Query: 671 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG 730
C+ +C C NGGTC D + F C CP G+ TC +++ + C NPCV+ G C
Sbjct: 675 CNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTC-LSEVNECNSNPCVH-GACRD 732
Query: 731 SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINI 790
S + C C GW G C N N+C PC NGG C D + + C C GF+GP+C+ NI
Sbjct: 733 SLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNI 792
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVED 850
+EC S+PC TC+D++ GY+C+C G C+ V+
Sbjct: 793 NECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLA--------------------P 832
Query: 851 CNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPL---GQRCLEKAPGQCLRPPCEA 907
C C +G C + E+ S CP GQ C E +C+ PC
Sbjct: 833 CAPSPCRNGGE-----------CRQSEDYESFSCVCPTGWQGQTC-EVDINECVLSPCRH 880
Query: 908 WGECGAEEPPSTPCLPRSGHLDNNC 932
C C ++G+ NC
Sbjct: 881 GASC-QNTHGGYRCHCQAGYSGRNC 904
Score = 481 bits (1239), Expect = e-135
Identities = 250/706 (35%), Positives = 350/706 (49%), Gaps = 71/706 (10%)
Query: 239 ECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC----DECVPYPGCVHGSC---VEPW 291
EC CK G L G T C C+ G+ G C DEC P P C +GSC V +
Sbjct: 531 ECASTPCKNGAKCLDGPNTYT--CVCTEGYTGTHCEVDIDECDPDP-CHYGSCKDGVATF 587
Query: 292 QCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC 351
C C + G C+ ++N C S PC +GGTC + + + Y C C G +G NCE C
Sbjct: 588 TCLCRPGYTGHHCETNINECSSQ-PCRHGGTCQDRD-NAYLCFCLKGTTGPNCEINLDDC 645
Query: 352 TSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411
S+PC + G+C + G+EC C G++G C ++IDECA NPC GGTC D ++GF C C
Sbjct: 646 ASSPC-DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRC 704
Query: 412 PEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCH 470
PE + TC +VN+C C H G C+D +NGY+C C G+ G +C++ +EC S+PC
Sbjct: 705 PEGYHDPTCLSEVNECNSNPCVH-GACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV 763
Query: 471 SGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 530
+GG C+D+ G+ C C +GFSGP C+ +++ C +PC N C + Y C C + G
Sbjct: 764 NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTG 823
Query: 531 KNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF 590
C V PC CR C S+ +FSC+C +G+
Sbjct: 824 ATCEVVLAPCAPSPCRNGGECRQ----------------------SEDYESFSCVCPTGW 861
Query: 591 TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGR 650
G C +I++C+ PCR+G +C + +RC C +G+ G C+T+ +DC P+PCH+ G
Sbjct: 862 QGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGS 921
Query: 651 CYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 710
C D +N +C C G++G C +C + C NG C D D++ C CP G+ G C
Sbjct: 922 CTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCE 981
Query: 711 VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGV 770
C + C NGGTCV SF+C+C G+ G C H+ N+C+ PC +GG C DG
Sbjct: 982 -NNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGC 1040
Query: 771 NWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRC------ 824
+RC C G+ GP+C+ + C SSPC G C YRC CP G G C
Sbjct: 1041 GSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVS 1100
Query: 825 ------QEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLDGRRD--CSKV--WCGWKP 872
++ + R C HG V+ N+ CRC G C + C P
Sbjct: 1101 CEVAAQRQGVDVARLC-------QHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSP 1153
Query: 873 C----LLAGQPEALSAQCPLGQ---RCLEKAPGQCLRPPCEAWGEC 911
C S +C G C E+ +CL PC+ G C
Sbjct: 1154 CQNGATCTDYLGGYSCKCVAGYHGVNCSEEI-DECLSHPCQNGGTC 1198
Score = 480 bits (1235), Expect = e-135
Identities = 258/723 (35%), Positives = 363/723 (50%), Gaps = 70/723 (9%)
Query: 240 CKEAVCKQG--CNLLHGGCTVPGECRCSYGWQGRFC---DECVPYPGCVHGSCVEPWQ-- 292
C C+ G C+LL +CRC GW G+ C D C P C +G P++
Sbjct: 106 CLTNPCRNGGTCDLL---TLTEYKCRCPPGWSGKSCQQADPCASNP-CANGGQCLPFEAS 161
Query: 293 --CNCETNWGGLLCDKDLNYCGSHHP-CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEH 349
C+C ++ G C +D+N CG C +GGTC N E YRC C ++G NCE+
Sbjct: 162 YICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHN-EVGSYRCVCRATHTGPNCERPYV 220
Query: 350 ACTSNPCANGGSCHEVPSG---FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG 406
C+ +PC NGG+C P+G EC C G++G C +ID+C N C GG CVD V+
Sbjct: 221 PCSPSPCQNGGTCR--PTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNT 278
Query: 407 FECICPEQWVGATCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE 463
+ C CP +W G C DV++C+ CQ+GGTC + GY CVC G+ G C D+
Sbjct: 279 YNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDD 338
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYN--LEGDYY 521
CAS+ C G C D F+C CP G +G LC ++ D C +PC G+ C + G
Sbjct: 339 CASAACFHGATCHDRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPVNGKAI 397
Query: 522 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN 581
C CP + G CS + +D C A P C G+C++ G+
Sbjct: 398 CTCPSGYTGPACS-----------QDVDECSLGANP----------CEHAGKCINTL-GS 435
Query: 582 FSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
F C C G+TG C ++++C+ PC+N TC+D++ F+C C G+EG C+ N ++C
Sbjct: 436 FECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECA 495
Query: 642 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP 701
PC GRC D +N+F C C G+ G C +C + C NG C D +T+ C C
Sbjct: 496 SSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCT 555
Query: 702 PGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCY 761
G+ G+ C V C P+PC + G+C A+F+C+CR G+ G C N N+C+ PC
Sbjct: 556 EGYTGTHCEV-DIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCR 613
Query: 762 NGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAG 821
+GG C D N + C C G GP+C IN+D+C SSPC G TC+D+I+GY C+C PG G
Sbjct: 614 HGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSG-TCLDKIDGYECACEPGYTG 672
Query: 822 PRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN--SCRCLDGRRD---CSKV-WCGWKPCLL 875
C I C G P +G + + N +CRC +G D S+V C PC+
Sbjct: 673 SMCNINID---EC--AGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVH 727
Query: 876 AGQPEALSA-QCPL-----GQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLD 929
++L+ +C G C + +C PC G C + C R G
Sbjct: 728 GACRDSLNGYKCDCDPGWSGTNC-DINNNECESNPCVNGGTC-KDMTSGYVCTCREGFSG 785
Query: 930 NNC 932
NC
Sbjct: 786 PNC 788
Score = 477 bits (1228), Expect = e-134
Identities = 268/793 (33%), Positives = 369/793 (46%), Gaps = 100/793 (12%)
Query: 198 CDENYYSATCN---KFCRPRNDFFGH-------YTCDQYGNKACMDGWMGKECKEAV--- 244
C E Y C C P +G +TC C G+ G C+ +
Sbjct: 554 CTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTC------LCRPGYTGHHCETNINEC 607
Query: 245 CKQGCNLLHGGCTVPGE----CRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQC 293
Q C HGG + C C G G C D+C P C G+C ++ ++C
Sbjct: 608 SSQPCR--HGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSP-CDSGTCLDKIDGYEC 664
Query: 294 NCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTS 353
CE + G +C+ +++ C + PC NGGTC + + + C CP+GY C + C S
Sbjct: 665 ACEPGYTGSMCNINIDECAGN-PCHNGGTCEDGI-NGFTCRCPEGYHDPTCLSEVNECNS 722
Query: 354 NPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPE 413
NPC +G +C + +G++C C GWSG C ++ +EC SNPC GGTC D G+ C C E
Sbjct: 723 NPCVHG-ACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCRE 781
Query: 414 QWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSG 472
+ G CQ ++N+C C + GTC D V GY+C C + G CE+ CA SPC +G
Sbjct: 782 GFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNG 841
Query: 473 GLCEDLAD--GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 530
G C D F C CP G+ G CEVD++ C SPCR+GA C N G Y C C + G
Sbjct: 842 GECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSG 901
Query: 531 KNCSVPREPCP------GGACRVIDGCGS---DAGPGMPGT--------AASGVCGPHGR 573
+NC + C GG+C DG + D PG GT AS C
Sbjct: 902 RNCETDIDDCRPNPCHNGGSCT--DGINTAFCDCLPGFRGTFCEEDINECASDPCRNGAN 959
Query: 574 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
C +++C C +GF+G +C N DC C NGGTC+D +++F C CP G+ G C
Sbjct: 960 CTDCVD-SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYC 1018
Query: 634 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 693
+ N+C PC G C D + C C G+ G C + CD+ C NGG C+ +
Sbjct: 1019 QHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTH 1078
Query: 694 DTFRCACPPGWKGSTCAVAKNSSC----------LPNPCVNGGTCVGSGASFSCICRDGW 743
+RC CP GW G C V + SC + C +GG CV +G + C C+ G+
Sbjct: 1079 TQYRCECPSGWTGLYCDVP-SVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGY 1137
Query: 744 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGAT 803
G C ++C+P PC NG C D + + C+C G+ G +C IDEC S PC G T
Sbjct: 1138 TGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGT 1197
Query: 804 CVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDC 863
C+D N Y+CSCP G G C+ + C P S + N+ C+D
Sbjct: 1198 CLDLPNTYKCSCPRGTQGVHCEINVD---DC---NPPVDPVSRSPKCFNNGTCVD----- 1246
Query: 864 SKVWCGWKPCLLAGQPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWG-ECGAEEPPST 919
Q S CP +G+RC E +CL PC+A G + +
Sbjct: 1247 --------------QVGGYSCTCPPGFVGERC-EGDVNECLSNPCDARGTQNCVQRVNDF 1291
Query: 920 PCLPRSGHLDNNC 932
C R+GH C
Sbjct: 1292 HCECRAGHTGRRC 1304
Score = 473 bits (1216), Expect = e-133
Identities = 246/769 (31%), Positives = 352/769 (45%), Gaps = 123/769 (15%)
Query: 202 YYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGE 261
++ ATC+ D + C+ + + + C C +G N
Sbjct: 345 FHGATCH-------DRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAI 397
Query: 262 CRCSYGWQGRFC----DEC-VPYPGCVH-GSCVEP---WQCNCETNWGGLLCDKDLNYCG 312
C C G+ G C DEC + C H G C+ ++C C + G C+ D+N C
Sbjct: 398 CTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECV 457
Query: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECH 372
S+ PC N TC++ + +++C C GY G +CE C S+PC + G C + + F+C
Sbjct: 458 SN-PCQNDATCLD-QIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCE 515
Query: 373 CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD--------- 423
CP+G++G C D+DECAS PC G C+D + + C+C E + G C++D
Sbjct: 516 CPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPC 575
Query: 424 ----------------------------VNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGG 454
+N+C Q C+HGGTC+D N Y C C +G G
Sbjct: 576 HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTG 635
Query: 455 RHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY 514
+CE+ D+CASSPC S G C D DG+ C C G++G +C +++D C +PC NG C
Sbjct: 636 PNCEINLDDCASSPCDS-GTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCE 694
Query: 515 NLEGDYYCACPDDFGGKNC-----SVPREPCPGGACR-VIDGCGSDAGPGMPGT------ 562
+ + C CP+ + C PC GACR ++G D PG GT
Sbjct: 695 DGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINN 754
Query: 563 --AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEV--- 617
S C G C G + C C GF+G C NI++C PC N GTCID+V
Sbjct: 755 NECESNPCVNGGTCKDMTSG-YVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGY 813
Query: 618 -------------------------------------DAFRCFCPSGWEGELCDTNPNDC 640
++F C CP+GW+G+ C+ + N+C
Sbjct: 814 KCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINEC 873
Query: 641 LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCAC 700
+ PC C + + C C G+ G+ C + C C NGG+C D +T C C
Sbjct: 874 VLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDC 933
Query: 701 PPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760
PG++G+ C N C +PC NG C S++C C G+ G C +NT DC C
Sbjct: 934 LPGFRGTFCEEDIN-ECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSC 992
Query: 761 YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRA 820
+NGG CVDG+N F C C PGF G C+ +++EC S PC +G TC D YRC+CP G
Sbjct: 993 FNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYT 1052
Query: 821 GPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCG 869
GP CQ ++ W +P +G + RC +C W G
Sbjct: 1053 GPNCQNLVH-----WCDSSPCKNGGKCWQTHTQYRC-----ECPSGWTG 1091
Score = 429 bits (1104), Expect = e-120
Identities = 278/852 (32%), Positives = 364/852 (42%), Gaps = 114/852 (13%)
Query: 198 CDENYYSATC---NKFCRPR--------NDFFGHYTCDQYGNKACMDGWMGKECKEAV-- 244
CD + C N C D Y C C +G+ G C+ +
Sbjct: 741 CDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVC------TCREGFSGPNCQTNINE 794
Query: 245 CKQGCNLLHGGCT--VPG-ECRCSYGWQGRFCD----ECVPYPGCVHGSC-----VEPWQ 292
C L G C V G +C C + G C+ C P P G C E +
Sbjct: 795 CASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFS 854
Query: 293 CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACT 352
C C T W G C+ D+N C PC +G +C N YRC C GYSGRNCE C
Sbjct: 855 CVCPTGWQGQTCEVDINECVLS-PCRHGASCQNTHGG-YRCHCQAGYSGRNCETDIDDCR 912
Query: 353 SNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICP 412
NPC NGGSC + + C C G+ G C DI+ECAS+PC G C D VD + C CP
Sbjct: 913 PNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCP 972
Query: 413 EQWVGATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHS 471
+ G C+ + DC C +GGTC D +N + C+CP GF G +C+ + +EC S PC
Sbjct: 973 AGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLH 1032
Query: 472 GGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGK 531
GG C+D + C CPQG++GP C+ V C+ SPC+NG +C+ Y C CP + G
Sbjct: 1033 GGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGL 1092
Query: 532 NCSVPREPCPGGACRV-ID--------GCGSDAG--------PGMPGTAASGV---CGP- 570
C VP C A R +D G DAG G G+ + C P
Sbjct: 1093 YCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPS 1152
Query: 571 ---HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 627
+G + G +SC C +G+ G C E ID+CL PC+NGGTC+D + ++C CP G
Sbjct: 1153 PCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRG 1212
Query: 628 WEGELCDTNPNDCLP--DP------CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 679
+G C+ N +DC P DP C + G C D V + C C G+ G+ C +C
Sbjct: 1213 TQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECL 1272
Query: 680 AYTCSNGGT--CYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV---GSGAS 734
+ C GT C + F C C G G C N C PC NGGTC +
Sbjct: 1273 SNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVING-CKGKPCKNGGTCAVASNTARG 1331
Query: 735 FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ 794
F C C G+EG TC ++ C L C NGG C+ G C C F GP+C+
Sbjct: 1332 FICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFP----A 1387
Query: 795 SSPCAYGATC--------VDEINGYRCSCPPGRAGPRCQEV-IGFGRSCWSRGTPFPHGS 845
SSPC G C E YRC CP G C + FG R P P
Sbjct: 1388 SSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGA-GRDIPPP--- 1443
Query: 846 SWVEDCNSCRCLD--GRRDCSKVWCGWKPCLLAGQPEALS-----AQCPLGQRCLE---- 894
E C C + G + CS + C C G +L+ C +C +
Sbjct: 1444 LIEEACELPECQEDAGNKVCS-LQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSD 1502
Query: 895 -KAPGQCLRPPCEAWG-ECGAEEPPSTPCLPR-------SGHLDNNCARLTLHFN----R 941
QC C G +C E P + GH D C ++
Sbjct: 1503 GHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCA 1562
Query: 942 DHVPQGTTVGAI 953
+HVP+ G +
Sbjct: 1563 EHVPERLAAGTL 1574
Score = 357 bits (917), Expect = 3e-98
Identities = 207/642 (32%), Positives = 281/642 (43%), Gaps = 99/642 (15%)
Query: 356 CANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTC--VDQ--VDGFECIC 411
C NGG C C C + GP C D + C S PC GTC VD+ V + C C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHVVDRRGVADYACSC 89
Query: 412 PEQWVGATC--QLDVNDCRGQCQHGGTCKDL-VNGYQCVCPRGFGGRHCELERDECASSP 468
+ G C LD C++GGTC L + Y+C CP G+ G+ C+ + D CAS+P
Sbjct: 90 ALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ-QADPCASNP 148
Query: 469 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACPD 526
C +GG C + CHCP F GP C DV+ C +P CR+G C+N G Y C C
Sbjct: 149 CANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRA 208
Query: 527 DFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 586
G NC P PC C+ G C P G + C C
Sbjct: 209 THTGPNCERPYVPCSPSPCQ-----------------NGGTCRPTGDVTHE------CAC 245
Query: 587 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC--LPDP 644
GFTG C ENIDDC G C+NGG C+D V+ + C CP W G+ C + ++C +P+
Sbjct: 246 LPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNA 305
Query: 645 CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGW 704
C + G C++ + C C +GW G+ C C + C +G TC+D +F C CP G
Sbjct: 306 CQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGR 365
Query: 705 KGSTCAVAKNSSCLPNPC----------VNG----------------------------- 725
G C + N +C+ NPC VNG
Sbjct: 366 TGLLCHL--NDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPC 423
Query: 726 ---GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA 782
G C+ + SF C C G+ G C + N+C PC N C+D + F+C C PG+
Sbjct: 424 EHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYE 483
Query: 783 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFP 842
G C +N DEC SSPC + C+D+IN ++C CP G G CQ + C S TP
Sbjct: 484 GVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVD---ECAS--TPCK 538
Query: 843 HGSSWVEDCN--SCRCLDG----RRDCSKVWCGWKPCLLAGQPEALSAQCPL------GQ 890
+G+ ++ N +C C +G + C PC + ++ L G
Sbjct: 539 NGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGH 598
Query: 891 RCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
C E +C PC G C + + C G NC
Sbjct: 599 HC-ETNINECSSQPCRHGGTC-QDRDNAYLCFCLKGTTGPNC 638
Score = 171 bits (433), Expect = 4e-42
Identities = 111/369 (30%), Positives = 149/369 (40%), Gaps = 70/369 (18%)
Query: 604 GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDL----VNDFY 659
G+ C NGG C C C + G C +PN CL PC + G C+ + V D+
Sbjct: 28 GETCLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPCLSTPCKNAGTCHVVDRRGVADYA 86
Query: 660 CACDDGWKGKTCHS-REFQCDAYTCSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 717
C+C G+ G C + + C C NGGTC + ++C CPPGW G +C A C
Sbjct: 87 CSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQA--DPC 144
Query: 718 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTND----------------------- 754
NPC NGG C+ AS+ C C + G TC + N+
Sbjct: 145 ASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRC 204
Query: 755 -----------------CNPLPCYNGGIC-VDGVNWFRCECAPGFAGPDCRINIDECQSS 796
C+P PC NGG C G C C PGF G +C NID+C +
Sbjct: 205 VCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGN 264
Query: 797 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG----FGRSCWSRGTPF-PHG------- 844
C G CVD +N Y C CPP G C E + +C + GT HG
Sbjct: 265 NCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCV 324
Query: 845 SSWV-EDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR-CLEKAPGQCLR 902
+ W EDC+ + DC+ C + + + +CP G+ L C+
Sbjct: 325 NGWTGEDCS-----ENIDDCASAAC-FHGATCHDRVASFYCECPHGRTGLLCHLNDACIS 378
Query: 903 PPCEAWGEC 911
PC C
Sbjct: 379 NPCNEGSNC 387
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 489 bits (1260), Expect = e-138
Identities = 237/541 (43%), Positives = 295/541 (54%), Gaps = 29/541 (5%)
Query: 28 GYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGP 87
G FEL+L N G L + CC G G C T+ RVCLK YQA V+P P
Sbjct: 23 GVFELKLQEFVNKKGLLGNRNCCRG------GAGPPPCACRTFFRVCLKHYQASVSPEPP 76
Query: 88 CSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVE 147
C+YG TPVLG +SF LP G A R PF F WP +F+LI+E
Sbjct: 77 CTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIR-----------FPFGFTWPGTFSLIIE 125
Query: 148 AWDWDND---TTPNEELLIERVSHAGMINPEDRW-KSLHFSGHVAHLELQIRVRCDENYY 203
A D+ T N E LI R++ + + W + LH SG L+ R CDE+YY
Sbjct: 126 ALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRT-DLKYSYRFVCDEHYY 184
Query: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263
C+ FCRPR+D FGH+TC + G K C GW G C E +C GC+ HG C PGEC+
Sbjct: 185 GEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECK 244
Query: 264 CSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
C GWQGR+CDEC+ YPGC+HG+C +PWQCNC+ WGGL C++DLNYC H PC NG TC
Sbjct: 245 CRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383
N Y C+C GY+G CE C +PC NGGSC ++ + + C CP G+ G C
Sbjct: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
Query: 384 LDIDECASNPCAAGGTCVDQVD-GFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLV 441
L CA PC GG C D D G+ C CP + G C+ ++ C C +G C DL
Sbjct: 365 LSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLG 424
Query: 442 NGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 501
+ Y C C GF GRHC+ D+CASSPC +GG C D + F C CP G++G C V
Sbjct: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSR 484
Query: 502 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS--VPREPCPGGACRVIDGCGSDAGPGM 559
CE +PC NGA C+ Y C C +GG NC +P P PG A V+D G G
Sbjct: 485 CEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELP-PGPA--VVDLTEKLEGQGG 541
Query: 560 P 560
P
Sbjct: 542 P 542
Score = 241 bits (616), Expect = 2e-63
Identities = 134/387 (34%), Positives = 173/387 (44%), Gaps = 53/387 (13%)
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGG-SCHEVPSGFECHCPSGWSGPTCALDIDEC 389
YR C + Y G C C A G +C E E C GW GP C I
Sbjct: 175 YRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERG---EKVCNPGWKGPYCTEPI--- 225
Query: 390 ASNPCAAGGTCVDQVDGF-----ECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGY 444
C G D+ GF EC C W G C + C HG TC+ +
Sbjct: 226 ----CLPG---CDEQHGFCDKPGECKCRVGWQGRYCDECIR--YPGCLHG-TCQQ---PW 272
Query: 445 QCVCPRGFGGRHCELERDECAS-SPCHSGGLCEDLADG-FHCHCPQGFSGPLCEVDVDLC 502
QC C G+GG C + + C PC +G C + G + C C G++G CE+ +D C
Sbjct: 273 QCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDEC 332
Query: 503 EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 562
+PSPC+NG C +LE Y C CP F GK C + C
Sbjct: 333 DPSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTC---------------------- 370
Query: 563 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 622
A G C GRC P G +SC C G++G C + ID C PC NG C+D DA+ C
Sbjct: 371 -ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLC 429
Query: 623 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 682
C +G+ G CD N +DC PC + G C D VNDF C C G+ G+ C + +C+
Sbjct: 430 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP 489
Query: 683 CSNGGTCYDSGDTFRCACPPGWKGSTC 709
C NG TC++ G + C C G+ G C
Sbjct: 490 CHNGATCHERGHRYVCECARGYGGPNC 516
Score = 225 bits (574), Expect = 2e-58
Identities = 141/452 (31%), Positives = 189/452 (41%), Gaps = 77/452 (17%)
Query: 422 LDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADG 481
L V + Q H DL Y+ VC + G C + C D
Sbjct: 153 LTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV--------------FCRPRDDA 198
Query: 482 F-HCHCPQ--------GFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKN 532
F H C + G+ GP C + C P C + G+ C C + G+
Sbjct: 199 FGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGRY 253
Query: 533 CSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTG 592
C C GC HG C QP + C C G+ G
Sbjct: 254 CD---------ECIRYPGC------------------LHGTC-QQP---WQCNCQEGWGG 282
Query: 593 TYCHENIDDCLG-QPCRNGGTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGR 650
+C+++++ C +PC+NG TC + ++ C C G+ G C+ ++C P PC + G
Sbjct: 283 LFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGS 342
Query: 651 CYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTC 709
C DL N + C C G+ GK C C C NGG C DS D + C CP G+ G C
Sbjct: 343 CTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNC 402
Query: 710 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDG 769
K C +PC NG CV G ++ C C+ G+ GR C N +DC PC NGG C DG
Sbjct: 403 E-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDG 461
Query: 770 VNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ---- 825
VN F C C PG+ G +C + C+ +PC GATC + + Y C C G GP CQ
Sbjct: 462 VNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLP 521
Query: 826 ------EVIGFGRSCWSRGTPFPHGSSWVEDC 851
V+ +G PFP WV C
Sbjct: 522 ELPPGPAVVDLTEKLEGQGGPFP----WVAVC 549
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 472 bits (1215), Expect = e-133
Identities = 243/710 (34%), Positives = 340/710 (47%), Gaps = 120/710 (16%)
Query: 261 ECRCSYGWQGRFCDE----CVPYPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGS 313
EC+C+ G+ G C+E C P P C HG C ++ + C C + G +C ++ C S
Sbjct: 555 ECQCATGFTGVLCEENIDNCDPDP-CHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYS 613
Query: 314 HHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHC 373
PC N G CI+ + Y+C C G SG NCE C SNPC +G C + + + C C
Sbjct: 614 S-PCLNDGRCIDLV-NGYQCNCQPGTSGVNCEINFDDCASNPCIHG-ICMDGINRYSCVC 670
Query: 374 PSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQ------------------- 414
G++G C +DIDECASNPC G TC++ V+GF CICPE
Sbjct: 671 SPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCI 730
Query: 415 ------------------WVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGR 455
WVG C++D N+C CQ+GGTC +LVNGY+C C +GF G
Sbjct: 731 HGNCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGY 790
Query: 456 HCELERDECASSPCHSGGLCEDLADGFHCHC----------------------------- 486
+C++ DECAS+PC + G C D G+ CHC
Sbjct: 791 NCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKE 850
Query: 487 -----------PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 535
G+ G C +D+D C PC N C+N +G Y C CP F G +C
Sbjct: 851 SPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEE 910
Query: 536 PREPCPGGACR----VIDGCGSDAGPGMPGTAASGVCGPHGRCVSQP---GG-------N 581
+ C C+ +DG + + +PG C+S+P GG +
Sbjct: 911 DIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNS 970
Query: 582 FSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
++C C +GF G +C NI++C C NGGTC+D +++F C CP G+ G C N+C
Sbjct: 971 YTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECS 1030
Query: 642 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP 701
PC + G C D + + C+C G+ GK C + C C N GTC +C CP
Sbjct: 1031 SHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCP 1090
Query: 702 PGWKGSTCAVAKNSSC----------LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 751
GW G+ C V N SC + + C + G C+ +G + C C G+ G C
Sbjct: 1091 SGWAGAYCDV-PNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQ 1149
Query: 752 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811
++C PC +G C D + +RCEC PG+ G +C +DECQ+ PC G TC+D +N +
Sbjct: 1150 LDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHF 1209
Query: 812 RCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN--SCRCLDG 859
+CSCPPG G C+E I C +RG +G ++ SCRCL G
Sbjct: 1210 KCSCPPGTRGLLCEENID---DC-ARGPHCLNGGQCMDRIGGYSCRCLPG 1255
Score = 469 bits (1208), Expect = e-132
Identities = 263/805 (32%), Positives = 374/805 (46%), Gaps = 104/805 (12%)
Query: 211 CRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV------------------------CK 246
C RN G Y C C++GW G +C E + C
Sbjct: 315 CANRN---GGYGC------VCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCP 365
Query: 247 QG-----CNL--------LHGGCTVPGE-------CRCSYGWQGRFC----DECVPYPG- 281
+G C+L H G C C G++G C DEC
Sbjct: 366 EGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSN 425
Query: 282 -CVH-GSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
C H G CV + C C + G C+ D+N C S PC N TC++ + + C C
Sbjct: 426 PCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSD-PCQNDATCLD-KIGGFTCLCM 483
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396
G+ G +CE + C SNPC N G C + + F+C CP G++GP C +DID+C+S PC
Sbjct: 484 PGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLN 543
Query: 397 GGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRH 456
G C+D +G+EC C + G C+ ++++C H G C+D ++ Y C+C G+ G
Sbjct: 544 GAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMGAI 603
Query: 457 CELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNL 516
C + DEC SSPC + G C DL +G+ C+C G SG CE++ D C +PC +G C +
Sbjct: 604 CSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIHGI-CMDG 662
Query: 517 EGDYYCACPDDFGGKNCSVPREPCPGGACR----VIDG-----CGSDAGPGMP------G 561
Y C C F G+ C++ + C CR I+G C GP P
Sbjct: 663 INRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVN 722
Query: 562 TAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFR 621
S C HG C G + C+CD+G+ G C + ++CL PC+NGGTC + V+ +R
Sbjct: 723 ECLSNPC-IHGNCTGGLSG-YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYR 780
Query: 622 CFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAY 681
C C G++G C N ++C +PC ++G C+D ++ + C C + GK C + C
Sbjct: 781 CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPN 840
Query: 682 TCSNGGTCYDSG--DTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCIC 739
C N C +S +++ C C PGW+G C + C+ PC+N G C + S+ C C
Sbjct: 841 PCENAAVCKESPNFESYTCLCAPGWQGQRCTI-DIDECISKPCMNHGLCHNTQGSYMCEC 899
Query: 740 RDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCA 799
G+ G C + +DC PC NGG C+DGVN F C C PGF G C+ +++EC S PC
Sbjct: 900 PPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCK 959
Query: 800 YGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDC----NS 853
G TC D +N Y C C G G C+ I SC++ GT +S+ C
Sbjct: 960 NGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTG 1019
Query: 854 CRCLDGRRDCSKVWCGWKPCLLAGQ----PEALSAQCPLGQ--RCLEKAPGQCLRPPCEA 907
CL +CS PCL G CPLG + + C R PC+
Sbjct: 1020 SFCLHEINECSS-----HPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKN 1074
Query: 908 WGECGAEEPPSTPCLPRSGHLDNNC 932
G C ++ + CL SG C
Sbjct: 1075 KGTC-VQKKAESQCLCPSGWAGAYC 1098
Score = 456 bits (1174), Expect = e-128
Identities = 265/803 (33%), Positives = 380/803 (47%), Gaps = 106/803 (13%)
Query: 222 TCDQYGNK---ACMDGWMGKECKEAV--CKQGCNLLHGGC--TVPG--ECRCSYGWQGRF 272
TC N+ C+ G+ G++C+ V C + HGG +PG +C+C G+ G++
Sbjct: 158 TCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQY 217
Query: 273 CDE----CVPYPGCVHGSCVEP----WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI 324
CD C P P G+C + ++CNC + G C+++++ C +H C NGG C+
Sbjct: 218 CDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR-CQNGGVCV 276
Query: 325 NAEPDQYRCTCPDGYSGRNCEKAEHACTSNP--CANGGSCHEVPSGFECHCPSGWSGPTC 382
+ + Y C CP ++G+ C + C P C NGG+C G+ C C +GWSG C
Sbjct: 277 DGV-NTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Query: 383 ALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTC-KDLV 441
+ +ID+CA C G TC+D+V F C+CPE G C LD C G C + +
Sbjct: 336 SENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPL 395
Query: 442 NG-YQCVCPRGFGGRHCELERDECA---SSPCHSGGLCEDLADGFHCHCPQGFSGPLCEV 497
NG Y C CP+G+ G C + DECA S+PC G C + FHC C +G++GP CE+
Sbjct: 396 NGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEM 455
Query: 498 DVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC----------------- 540
D++ C PC+N A C + G + C C F G +C + C
Sbjct: 456 DINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNR 515
Query: 541 ---------PGGACRV-IDGCGS----------DAGPGMPGTAASGV-----------CG 569
G C++ ID C S D G A+G C
Sbjct: 516 FQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCD 575
Query: 570 P----HGRCVSQPG-GNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFC 624
P HG+C Q G +++CIC+ G+ G C + ID+C PC N G CID V+ ++C C
Sbjct: 576 PDPCHHGQC--QDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNC 633
Query: 625 PSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCS 684
G G C+ N +DC +PC G C D +N + C C G+ G+ C+ +C + C
Sbjct: 634 QPGTSGVNCEINFDDCASNPC-IHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCR 692
Query: 685 NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 744
G TC + + FRC CP G +C ++ + CL NPC++ G C G + + C+C GW
Sbjct: 693 KGATCINGVNGFRCICPEGPHHPSC-YSQVNECLSNPCIH-GNCTGGLSGYKCLCDAGWV 750
Query: 745 GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 804
G C + N+C PC NGG C + VN +RC C GF G +C++NIDEC S+PC TC
Sbjct: 751 GINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTC 810
Query: 805 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN----SCRCLDG- 859
D+I+GY C C G CQ V+ C P + + E N +C C G
Sbjct: 811 FDDISGYTCHCVLPYTGKNCQTVLA---PC--SPNPCENAAVCKESPNFESYTCLCAPGW 865
Query: 860 ---RRDCSKVWCGWKPCLLAG----QPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWG 909
R C KPC+ G + +CP G C E+ CL PC+ G
Sbjct: 866 QGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDC-EEDIDDCLANPCQNGG 924
Query: 910 ECGAEEPPSTPCLPRSGHLDNNC 932
C + + CL G + C
Sbjct: 925 SC-MDGVNTFSCLCLPGFTGDKC 946
Score = 433 bits (1113), Expect = e-121
Identities = 268/872 (30%), Positives = 369/872 (42%), Gaps = 158/872 (18%)
Query: 216 DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGCT--VPG-ECRCSYGWQG 270
D YTC C G+MG C + + C L G C V G +C C G G
Sbjct: 586 DGIDSYTC------ICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG 639
Query: 271 RFC----DECVPYPGCVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
C D+C P C+HG C++ + C C + G C+ D++ C S+ PC G TC
Sbjct: 640 VNCEINFDDCASNP-CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASN-PCRKGATC 697
Query: 324 INAEPDQYRCTCPDG-------------------------------------YSGRNCEK 346
IN + +RC CP+G + G NCE
Sbjct: 698 INGV-NGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCEV 756
Query: 347 AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG 406
++ C SNPC NGG+C + +G+ C C G+ G C ++IDECASNPC GTC D + G
Sbjct: 757 DKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISG 816
Query: 407 FECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVN--GYQCVCPRGFGGRHCELERDE 463
+ C C + G CQ + C C++ CK+ N Y C+C G+ G+ C ++ DE
Sbjct: 817 YTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDE 876
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCA 523
C S PC + GLC + + C CP GFSG CE D+D C +PC+NG C + + C
Sbjct: 877 CISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCL 936
Query: 524 CPDDFGGKNCSVPR-----EPCP-GGACR-VIDGCGSDAGPGMPGT--------AASGVC 568
C F G C EPC GG C ++ G G C
Sbjct: 937 CLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTESSC 996
Query: 569 GPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW 628
G CV +FSC+C GFTG++C I++C PC N GTC+D + +RC CP G+
Sbjct: 997 FNGGTCVDGIN-SFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGY 1055
Query: 629 EGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDA-------- 680
G+ C T N C PC ++G C + C C GW G C CD
Sbjct: 1056 TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVL 1115
Query: 681 --YTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 738
+ C + G C ++G+T C CP G+ GS C + C NPC +G TC + C
Sbjct: 1116 VEHLCQHSGVCINAGNTHYCQCPLGYTGSYCE-EQLDECASNPCQHGATCSDFIGGYRCE 1174
Query: 739 CRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECA-------------------- 778
C G++G C + ++C PC NGG C+D VN F+C C
Sbjct: 1175 CVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPH 1234
Query: 779 -------------------PGFAGPDCRINIDECQSSPCAYGAT--CVDEINGYRCSCPP 817
PGFAG C +I+EC S+PC+ + C+ N Y C C
Sbjct: 1235 CLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRS 1294
Query: 818 GRAGPRCQEVIGF--GRSCWSRGTPFPHGSSWVEDCNSCRCLDG------RRDCSKVWC- 868
G C+ + C + GT +S + D CRC G + C +V C
Sbjct: 1295 AFTGRHCETFVDVCPQMPCLNGGTCAV--ASNMPDGFICRCPPGFSGARCQSSCGQVKCR 1352
Query: 869 -GWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAE-EPPSTPCL---P 923
G + A P CP + C C PC+ G C + +PP C P
Sbjct: 1353 KGEQCVHTASGPRCF---CPSPRDC----ESGCASSPCQHGGSCHPQRQPPYYSCQCAPP 1405
Query: 924 RSGHLDNNCARLTLHFNRDHVPQGTTVGAICS 955
SG +R L+ P T + C+
Sbjct: 1406 FSG------SRCELYTAPPSTPPATCLSQYCA 1431
Score = 427 bits (1099), Expect = e-119
Identities = 241/731 (32%), Positives = 348/731 (47%), Gaps = 67/731 (9%)
Query: 231 CMDGWMGKECKEAVCKQG-CNLLHGGCTVPGECRCSYGWQGRFC--------DECVPYPG 281
C DG+ E +G C H G G C+C G+ G +C + C
Sbjct: 28 CRDGY------EPCVNEGMCVTYHNGT---GYCKCPEGFLGEYCQHRDPCEKNRCQNGGT 78
Query: 282 CVHGSCVEPWQCNCETNWGGLLCDKDLNY-CGSHHPCTNGGTCINAEPDQYRCTCPDGYS 340
CV + + C C + + G C ++ C PC NGGTC D Y CTC G++
Sbjct: 79 CVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFT 138
Query: 341 GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDEC-ASNPCAAGGT 399
G+ C+ + AC S+PCANG +C V + F C C +G++G C D++EC C GGT
Sbjct: 139 GKECQWTD-ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGT 197
Query: 400 CVDQVDGFECICPEQWVGATC-QLDVNDCRGQCQHGGTCKDLVN-GYQCVCPRGFGGRHC 457
C++ ++C CP+ + G C L V C +GGTC+ + ++C C GF G C
Sbjct: 198 CLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTC 257
Query: 458 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC--EPSPCRNGARCYN 515
E D+C + C +GG+C D + ++C CP ++G C DVD C +P+ C+NG C N
Sbjct: 258 ERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCAN 317
Query: 516 LEGDYYCACPDDFGGKNCSVPREPC------PGGACRVIDGCGSDAGPGMPGTAASGVCG 569
G Y C C + + G +CS + C PG C ID S + P A +C
Sbjct: 318 RNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTC--IDRVASFSCM-CPEGKAGLLCH 374
Query: 570 PHGRCVSQP------------GGNFSCICDSGFTGTYCHENIDDCL---GQPCRNGGTCI 614
C+S P G + C C G+ G C E++D+C PC + G C+
Sbjct: 375 LDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCV 434
Query: 615 DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR 674
+ AF C C G+ G C+ + N+C DPC + C D + F C C G+KG C
Sbjct: 435 NTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELE 494
Query: 675 EFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 734
+C + C N G C D + F+C CPPG+ G C + C PC+NG C+
Sbjct: 495 INECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQI-DIDDCSSTPCLNGAKCIDHPNG 553
Query: 735 FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ 794
+ C C G+ G C N ++C+P PC++G C DG++ + C C PG+ G C IDEC
Sbjct: 554 YECQCATGFTGVLCEENIDNCDPDPCHHGQ-CQDGIDSYTCICNPGYMGAICSDQIDECY 612
Query: 795 SSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSC 854
SSPC C+D +NGY+C+C PG +G C+ I F C S P HG ++ N
Sbjct: 613 SSPCLNDGRCIDLVNGYQCNCQPGTSGVNCE--INFD-DCAS--NPCIHGIC-MDGINRY 666
Query: 855 RCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPG-QCLRPPCEAWGECGA 913
C+ CS + G + C + E S C G C+ G +C+ P C +
Sbjct: 667 SCV-----CSPGFTGQR-CNI-DIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYS 719
Query: 914 E--EPPSTPCL 922
+ E S PC+
Sbjct: 720 QVNECLSNPCI 730
Score = 139 bits (350), Expect = 2e-32
Identities = 103/340 (30%), Positives = 141/340 (41%), Gaps = 62/340 (18%)
Query: 203 YSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--CK-QGCNLLHGGCTVP 259
+ ATC+ DF G Y C+ C+ G+ G C+ V C+ Q C +GG +
Sbjct: 1160 HGATCS-------DFIGGYRCE------CVPGYQGVNCEYEVDECQNQPCQ--NGGTCID 1204
Query: 260 ----GECRCSYGWQGRFC----DECVPYPGCVHGS-CVEP---WQCNCETNWGGLLCDKD 307
+C C G +G C D+C P C++G C++ + C C + G C+ D
Sbjct: 1205 LVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGD 1264
Query: 308 LNYCGSHHPCTNGGT--CINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC--- 362
+N C S+ PC++ G+ CI D Y C C ++GR+CE C PC NGG+C
Sbjct: 1265 INECLSN-PCSSEGSLDCIQLTND-YLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVA 1322
Query: 363 HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQL 422
+P GF C CP G+SG C C C G CV G C CP
Sbjct: 1323 SNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPSP-------- 1371
Query: 423 DVNDCR-----GQCQHGGTCKDLVNG--YQCVCPRGFGGRHCELERDECASSP--CHSGG 473
DC CQHGG+C Y C C F G CEL ++ P C S
Sbjct: 1372 --RDCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQY 1429
Query: 474 LCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARC 513
+ DG C + + C+ D C + A C
Sbjct: 1430 CADKARDGV---CDEACNSHACQWDGGDCSLTMENPWANC 1466
Score = 42.0 bits (97), Expect = 0.004
Identities = 62/274 (22%), Positives = 81/274 (29%), Gaps = 113/274 (41%)
Query: 219 GHYTCDQYGNK---ACMDGWMGKECKEAV--CKQGCNLLHGGCTVPGE------CRCSYG 267
G C Q N C + G+ C+ V C Q L G C V CRC G
Sbjct: 1277 GSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPG 1336
Query: 268 WQGRFCD------ECVPYPGCVHGS----CVEPWQCNCETNWGGLLCDKDLNYCGSHHPC 317
+ G C +C CVH + C P +CE+ C S PC
Sbjct: 1337 FSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESG------------CASS-PC 1383
Query: 318 TNGGTCI-NAEPDQYRCTCPDGYSGRNCEK-------------------------AEHAC 351
+GG+C +P Y C C +SG CE + AC
Sbjct: 1384 QHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEAC 1443
Query: 352 TSNPCA-NGGSCH---EVP-----------------------------SGFEC------- 371
S+ C +GG C E P FEC
Sbjct: 1444 NSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTC 1503
Query: 372 -------------HCPSGWSGPTCALDIDECASN 392
HC G + C D +CA++
Sbjct: 1504 KYDKYCADHFKDNHCDQGCNSEECGWDGLDCAAD 1537
Score = 31.2 bits (69), Expect = 6.2
Identities = 21/74 (28%), Positives = 30/74 (40%), Gaps = 14/74 (18%)
Query: 201 NYYSATCNKFCRPRNDFFGHYTCDQYGNKACM-DGWMGKECKEAVCKQGCNLLHGGCTVP 259
+Y + C++ C F ++ C Q +K C D + K+ C QGCN
Sbjct: 1474 DYINNQCDELCNTVECLFDNFEC-QGNSKTCKYDKYCADHFKDNHCDQGCN--------S 1524
Query: 260 GECRCSYGWQGRFC 273
EC GW G C
Sbjct: 1525 EEC----GWDGLDC 1534
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 468 bits (1204), Expect = e-131
Identities = 265/753 (35%), Positives = 347/753 (46%), Gaps = 65/753 (8%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGG-CTVPGE----CRCSYGWQGRFC----DECVPYPG 281
C G+ G +C HG C+V + C C G+QGR C DEC
Sbjct: 108 CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167
Query: 282 CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337
C HG +C+ ++C C + G LC+ C PC NGGTC + Y C C
Sbjct: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPS-PCRNGGTCRQSGDLTYDCACLP 226
Query: 338 GYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP--CA 395
G+ G+NCE C + C NGG+C + + + C CP W+G C D+DEC P C
Sbjct: 227 GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACH 286
Query: 396 AGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGG 454
GGTC + + G C+C W G +C +++DC C HG TC D V + C CP G G
Sbjct: 287 NGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTG 346
Query: 455 RHCELERDECASSPCHSGGLCE--DLADGFHCHCPQGFSGPLCEVDVDLCE--PSPCRNG 510
C L+ D C S+PCH +C+ + C CP GF+G C+ DVD C +PC +
Sbjct: 347 LLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHL 405
Query: 511 ARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG-------PGMPGT- 562
RC N +G + C C + G C C G CR C G G GT
Sbjct: 406 GRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTY 465
Query: 563 -------AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCID 615
S C G C + G FSC C SGF+G+ C ++D+C PCRNG C+D
Sbjct: 466 CEVDIDECQSSPCVNGGVCKDRVNG-FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVD 524
Query: 616 EVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSRE 675
+ D + C C G+EG LCD N +DC PDPCH GRC D + F CAC G+ G C S+
Sbjct: 525 QPDGYECRCAEGFEGTLCDRNVDDCSPDPCH-HGRCVDGIASFSCACAPGYTGTRCESQV 583
Query: 676 FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASF 735
+C + C +GG C D D + C CP G G C V C NPC G C +
Sbjct: 584 DECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV-NIDDCASNPC-TFGVCRDGINRY 641
Query: 736 SCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQS 795
C+C+ G+ G C N+C PC GG CVDG N FRC C PG P C C
Sbjct: 642 DCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAH 701
Query: 796 SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG----FGRSCWSRGTPFPHGSSWVEDC 851
PC++G C D G+RC C PG +GPRC + + + C + GT G +
Sbjct: 702 EPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGF---- 756
Query: 852 NSCRCLDG--RRDCSKVW-CGWKPCLLAGQPEALSAQCPL--------GQRCLEKAPGQC 900
C C G R C + C PC G+ E+ Q P+ G RC ++ +C
Sbjct: 757 -HCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRC-QQDVDEC 814
Query: 901 LRP-PCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
P PC G C S C G+ +C
Sbjct: 815 AGPAPCGPHGIC-TNLAGSFSCTCHGGYTGPSC 846
Score = 463 bits (1191), Expect = e-130
Identities = 264/739 (35%), Positives = 342/739 (46%), Gaps = 102/739 (13%)
Query: 262 CRCSYGWQGRFCD----EC-VPYPGCVH-GSCVEP---WQCNCETNWGGLLCDKDLNYCG 312
C C G+ G CD EC + C H G CV + C C + G C+ D+N C
Sbjct: 377 CTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECL 436
Query: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECH 372
S PC N TC++ Q+ C C G++G CE C S+PC NGG C + +GF C
Sbjct: 437 SG-PCRNQATCLD-RIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCT 494
Query: 373 CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQ 432
CPSG+SG TC LD+DECAS PC G CVDQ DG+EC C E + G C +V+DC
Sbjct: 495 CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPC 554
Query: 433 HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG 492
H G C D + + C C G+ G CE + DEC S PC GG C DL D + C CP G +G
Sbjct: 555 HHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTG 614
Query: 493 PLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC------PGGACR 546
CEV++D C +PC G C + Y C C F G C+V C GG+C
Sbjct: 615 VNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSC- 672
Query: 547 VIDG-------CGSDAGPGM---PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCH 596
+DG C + P + P + HG C PGG F C+C+ G++G C
Sbjct: 673 -VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG-FRCVCEPGWSGPRCS 730
Query: 597 ENI--DDCLGQPCRNGGTCIDEVDAFR--------------------------------- 621
+++ D C QPCR GGTC + F
Sbjct: 731 QSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAP 790
Query: 622 -----CFCPSGWEGELCDTNPNDCL-PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSRE 675
C CP GW+G C + ++C P PC G C +L F C C G+ G +C
Sbjct: 791 GQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDI 850
Query: 676 FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASF 735
CD C NGG+C D +F C+C PG+ G CA CL NPC GTC ASF
Sbjct: 851 NDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCA-RDVDECLSNPC-GPGTCTDHVASF 908
Query: 736 SCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQS 795
+C C G+ G C + DC+P C+NGG CVDGVN F C C PG+ G C+ D C S
Sbjct: 909 TCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLS 968
Query: 796 SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCR 855
PC +G C G+RC+C GP+CQ ++ W P +G V+ C
Sbjct: 969 RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVD-----WCSRQPCQNGGRCVQTGAYCL 1023
Query: 856 CLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAP--GQCLRPPCEAWGECGA 913
C G W G + C + P C E A G L C+A G+C
Sbjct: 1024 CPPG-------WSG-RLCDIRSLP------------CREAAAQIGVRLEQLCQAGGQC-V 1062
Query: 914 EEPPSTPCLPRSGHLDNNC 932
+E S C+ G ++C
Sbjct: 1063 DEDSSHYCVCPEGRTGSHC 1081
Score = 456 bits (1174), Expect = e-128
Identities = 252/731 (34%), Positives = 337/731 (46%), Gaps = 83/731 (11%)
Query: 231 CMDGWMGKECKEAVCKQGCNL----LHGGCTVPG---ECRCSYGWQGRFCD---ECVPYP 280
C GW G C +++ + C G C+ G C C G QGR C+ C P P
Sbjct: 720 CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
Query: 281 GCVHGSCVE--PWQ---CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTC 335
C HG E P Q C+C W G C +D++ C PC G C N + CTC
Sbjct: 780 -CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLA-GSFSCTC 837
Query: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395
GY+G +C++ + C NPC NGGSC + F C C G++GP CA D+DEC SNPC
Sbjct: 838 HGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCG 897
Query: 396 AGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGG 454
G TC D V F C CP + G C+ D+ DC C +GGTC D VN + C+C G+ G
Sbjct: 898 PG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTG 956
Query: 455 RHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY 514
HC+ E D C S PC GG+C GF C C + F+GP C+ VD C PC+NG RC
Sbjct: 957 AHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC- 1015
Query: 515 NLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRC 574
++ YC CP + G+ C + PC A ++ G +C G+C
Sbjct: 1016 -VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQI-------------GVRLEQLCQAGGQC 1061
Query: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
V + ++ C+C G TG++C + +D CL QPC++GGTC + + C C G+ G+ C+
Sbjct: 1062 VDEDSSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
Query: 635 TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC-------DAYTCSNGG 687
+ ++C PC G C DLV + C+C G G C E C C + G
Sbjct: 1121 DDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNG 1180
Query: 688 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGT--CVGS-GASFSCICRDGWE 744
TC D FRC CPPG+ G C N C C T C+ G F C+C G+
Sbjct: 1181 TCVDLVGGFRCTCPPGYTGLRCEADINE-CRSGACHAAHTRDCLQDPGGGFRCLCHAGFS 1239
Query: 745 GRTCTHNTNDCNPLPCYNGGIC-----VDGVNWFRCECAPGFAGPDCRINIDECQSSPCA 799
G C + C PC +GG C G F C CA F GP C C+ C
Sbjct: 1240 GPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCP 1299
Query: 800 YGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG 859
G C G RC+CPPG +GP C+ G P G+S C + CL G
Sbjct: 1300 VGVPCQQTPRGPRCACPPGLSGPSCRSFPG-----------SPPGAS-NASCAAAPCLHG 1347
Query: 860 ------------RRDCSKVWCGWKPCLLAGQPE-ALSAQCP----LGQRCLEKAPGQCLR 902
R C++ W G + A PE + +CP +R ++ +C
Sbjct: 1348 GSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNS 1407
Query: 903 PPCEAW--GEC 911
P C W G+C
Sbjct: 1408 PGC-GWDGGDC 1417
Score = 436 bits (1121), Expect = e-122
Identities = 259/794 (32%), Positives = 346/794 (43%), Gaps = 128/794 (16%)
Query: 231 CMDGWMGK-------ECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCD----ECVPY 279
C G+ G EC C+ G + ECRC+ G++G CD +C P
Sbjct: 495 CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGY--ECRCAEGFEGTLCDRNVDDCSPD 552
Query: 280 PGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
P C HG CV+ + C C + G C+ ++ C S PC +GG C++ D+Y C CP
Sbjct: 553 P-CHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQ-PCRHGGKCLDLV-DKYLCRCP 609
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396
G +G NCE C SNPC G C + + ++C C G++GP C ++I+ECAS+PC
Sbjct: 610 SGTTGVNCEVNIDDCASNPCTFG-VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGE 668
Query: 397 GGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGR 455
GG+CVD +GF C+CP + C + C + C HG C D G++CVC G+ G
Sbjct: 669 GGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGP 727
Query: 456 HCE--LERDECASSPCHSGGLCEDLADGFHC----------------------------- 484
C L RD C S PC +GG C GFHC
Sbjct: 728 RCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCE 787
Query: 485 ---------HCPQGFSGPLCEVDVDLCE-PSPCRNGARCYNLEGDYYCACPDDFGGKNCS 534
CPQG+ GP C+ DVD C P+PC C NL G + C C + G +C
Sbjct: 788 SAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCD 847
Query: 535 VPREPCP------GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG-------- 580
C GG+C+ DG GS + +PG A C+S P G
Sbjct: 848 QDINDCDPNPCLNGGSCQ--DGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHV 905
Query: 581 -NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPND 639
+F+C C G+ G +C +++ DC C NGGTC+D V++F C C G+ G C +
Sbjct: 906 ASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADP 965
Query: 640 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCA 699
CL PC G C F C C + + G C + C C NGG C +G C
Sbjct: 966 CLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY--CL 1023
Query: 700 CPPGWKGSTC---------AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTH 750
CPPGW G C A A+ L C GG CV +S C+C +G G C
Sbjct: 1024 CPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQ 1083
Query: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 810
+ C PC +GG C + + CEC PG+ G +C ++DEC S PC +G +C+D +
Sbjct: 1084 EVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVAR 1143
Query: 811 YRCSCPPGRAGPRCQ---------EVIGFGRSCWSRGT-------------PFPHGSSWV 848
Y CSCPPG G C+ + G C GT P G
Sbjct: 1144 YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCE 1203
Query: 849 EDCNSCRC----LDGRRDCSKVWCGWKPCLL-AGQPEALSAQCPLGQRCLEKAPGQCLRP 903
D N CR RDC + G CL AG G RC + C
Sbjct: 1204 ADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS---------GPRC-QTVLSPCESQ 1253
Query: 904 PCEAWGECGAEEPP 917
PC+ G+C P
Sbjct: 1254 PCQHGGQCRPSPGP 1267
Score = 410 bits (1054), Expect = e-114
Identities = 236/677 (34%), Positives = 307/677 (45%), Gaps = 86/677 (12%)
Query: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH-EVPSG- 368
C PC NGG C + C CP G+ G C+ E C S PCA G C V +G
Sbjct: 43 CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQ-LEDPCHSGPCAGRGVCQSSVVAGT 101
Query: 369 --FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FECICPEQWVGATCQLDVN 425
F C CP G+ GP C+L D C S+PCA G C DG F C CP + G +C+ DV+
Sbjct: 102 ARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVD 160
Query: 426 DCR--GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD-GF 482
+CR C+HGGTC + ++C CP G+ G CE CA SPC +GG C D +
Sbjct: 161 ECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTY 220
Query: 483 HCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP- 541
C C GF G CEV+VD C C NG C + Y C CP ++ G+ C+ + C
Sbjct: 221 DCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQL 280
Query: 542 -------GGAC---------------------RVIDGCGSDA---GPGMPGTAASGVCG- 569
GG C + ID C + G AS C
Sbjct: 281 QPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCAC 340
Query: 570 PHGR----------CVSQP------------GGNFSCICDSGFTGTYCHENIDDCL--GQ 605
P G+ CVS P G C C GFTG C +++D+C
Sbjct: 341 PMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGAN 400
Query: 606 PCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDG 665
PC + G C++ +F C C G+ G C+T+ N+CL PC ++ C D + F C C G
Sbjct: 401 PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAG 460
Query: 666 WKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNG 725
+ G C +C + C NGG C D + F C CP G+ GSTC + + C PC NG
Sbjct: 461 FTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVD-ECASTPCRNG 519
Query: 726 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 785
CV + C C +G+EG C N +DC+P PC++G CVDG+ F C CAPG+ G
Sbjct: 520 AKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGR-CVDGIASFSCACAPGYTGTR 578
Query: 786 CRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 845
C +DEC+S PC +G C+D ++ Y C CP G G C+ I C S F
Sbjct: 579 CESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNID---DCASNPCTF---- 631
Query: 846 SWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPG-QCLRPP 904
CR R DC P E S+ C G C++ G +CL PP
Sbjct: 632 ------GVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGFRCLCPP 685
Query: 905 CEAWGECGAEEPPSTPC 921
C PPS PC
Sbjct: 686 GSLPPLC---LPPSHPC 699
Score = 347 bits (890), Expect = 4e-95
Identities = 207/602 (34%), Positives = 263/602 (43%), Gaps = 107/602 (17%)
Query: 376 GWSGPTCALDIDECASNPCAAGGTCVDQVDGFE--CICPEQWVGATCQLDVNDCRGQCQH 433
G + P C LD +PCA GG C Q+ E C+CP WVG CQL+ G C
Sbjct: 37 GAAAPPC-LD-----GSPCANGGRCT-QLPSREAACLCPPGWVGERCQLEDPCHSGPCAG 89
Query: 434 GGTCKDLVNG----YQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADG-FHCHCPQ 488
G C+ V + C CPRGF G C L D C SSPC G C DG F C CP
Sbjct: 90 RGVCQSSVVAGTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPP 148
Query: 489 GFSGPLCEVDVDLCE-PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRV 547
G+ G C DVD C PCR+G C N G + C CP + G C P PC CR
Sbjct: 149 GYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCR- 207
Query: 548 IDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPC 607
G C G + C C GF G C N+DDC G C
Sbjct: 208 ----------------NGGTCRQSGDL------TYDCACLPGFEGQNCEVNVDDCPGHRC 245
Query: 608 RNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC--LPDPCHSRGRCYDLVNDFYCACDDG 665
NGGTC+D V+ + C CP W G+ C + ++C P+ CH+ G C++ + C C +G
Sbjct: 246 LNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNG 305
Query: 666 WKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPC--- 722
W G++C C C +G TC+D +F CACP G G C + + +C+ NPC
Sbjct: 306 WTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHL--DDACVSNPCHED 363
Query: 723 -------VNG--------------------------------GTCVGSGASFSCICRDGW 743
VNG G CV + SF C C G+
Sbjct: 364 AICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY 423
Query: 744 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGAT 803
G C + N+C PC N C+D + F C C GF G C ++IDECQSSPC G
Sbjct: 424 TGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGV 483
Query: 804 CVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVE--DCNSCRCLDGRR 861
C D +NG+ C+CP G +G CQ + C S TP +G+ V+ D CRC +G
Sbjct: 484 CKDRVNGFSCTCPSGFSGSTCQLDVD---ECAS--TPCRNGAKCVDQPDGYECRCAEGFE 538
Query: 862 ---------DCSKVWCGWKPCLLAGQPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWG 909
DCS C C+ + S C G RC E +C PC G
Sbjct: 539 GTLCDRNVDDCSPDPCHHGRCV--DGIASFSCACAPGYTGTRC-ESQVDECRSQPCRHGG 595
Query: 910 EC 911
+C
Sbjct: 596 KC 597
Score = 338 bits (868), Expect = 1e-92
Identities = 229/745 (30%), Positives = 309/745 (41%), Gaps = 96/745 (12%)
Query: 197 RCDENYYSATCNKFCRPRN---DFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCN-LL 252
RC ++ C P + G ++C C G+ G C + + N L
Sbjct: 806 RCQQDVDECAGPAPCGPHGICTNLAGSFSC------TCHGGYTGPSCDQDINDCDPNPCL 859
Query: 253 HGGCTVPG----ECRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQCNCETNWGG 301
+GG G C C G+ G C DEC+ P C G+C V + C C +GG
Sbjct: 860 NGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP-CGPGTCTDHVASFTCTCPPGYGG 918
Query: 302 LLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGS 361
C++DL C S C NGGTC++ + + C C GY+G +C+ C S PC +GG
Sbjct: 919 FHCEQDLPDC-SPSSCFNGGTCVDGV-NSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGV 976
Query: 362 CHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQ 421
C GF C C ++GP C +D C+ PC GG CV G C+CP W G C
Sbjct: 977 CSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQT--GAYCLCPPGWSGRLCD 1034
Query: 422 LDVNDCRGQ-----------CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCH 470
+ CR CQ GG C D + + CVCP G G HCE E D C + PC
Sbjct: 1035 IRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQ 1094
Query: 471 SGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 530
GG C G+ C C G++G CE DVD C PC++G C +L Y C+CP G
Sbjct: 1095 HGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLG 1154
Query: 531 KNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF 590
C + + C GPG P + C +G CV GG F C C G+
Sbjct: 1155 VLCEINEDDC---------------GPG-PPLDSGPRCLHNGTCVDLVGG-FRCTCPPGY 1197
Query: 591 TGTYCHENIDDCLGQPCRNGGT--CI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 647
TG C +I++C C T C+ D FRC C +G+ G C T + C PC
Sbjct: 1198 TGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQH 1257
Query: 648 RGRCYDLVN-----DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
G+C F C C + G C C C G C + RCACPP
Sbjct: 1258 GGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQTPRGPRCACPP 1317
Query: 703 GWKGSTCAV-------AKNSSCLPNPCVNGGTCVGSGAS--FSCICRDGWEGRTC--THN 751
G G +C A N+SC PC++GG+C + + F C C GW G C
Sbjct: 1318 GLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAA 1377
Query: 752 TNDCNPLPCYNGGICVDGVNWFRC--EC---APGFAGPDCRINID----ECQSSPCAYGA 802
+ + P C RC EC G+ G DC +++ +C++
Sbjct: 1378 APEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEA------L 1431
Query: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 862
C N RC P + P C + C + G + + C + DGR D
Sbjct: 1432 QCWRLFNNSRCD--PACSSPAC---LYDNFDCHAGGRERTCNPVYEKYC-ADHFADGRCD 1485
Query: 863 --CSKVWCGWKPCLLAGQPEALSAQ 885
C+ CGW A + AL A+
Sbjct: 1486 QGCNTEECGWDGLDCASEVPALLAR 1510
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 465 bits (1197), Expect = e-130
Identities = 231/547 (42%), Positives = 298/547 (54%), Gaps = 38/547 (6%)
Query: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
M A R LLLL+ALW Q A G F+LQL N G L SG C+
Sbjct: 1 MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG------- 53
Query: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
C T+ RVCLK +QA V+P GPC++G +TPVLG NSF A D +
Sbjct: 54 ------CRTFFRVCLKHFQAVVSP-GPCTFGTVSTPVLGTNSF------AVRDDS----- 95
Query: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEEL----LIERVSHAGMINPED 176
+GG ++P + +PF F WP +F+LI+EAW D E L LI +++ G +
Sbjct: 96 SGGGRNP--LQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQ 153
Query: 177 RWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM 236
W + + L RV C +NYY C++ C+ RND FGHY C GN +C+ GW
Sbjct: 154 NWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWT 213
Query: 237 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE 296
G+ C++ +C GC+ +G C+ P EC C GWQGR C+EC+P+ GC HG+C PWQC C+
Sbjct: 214 GEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCD 273
Query: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
WGGL CD+DLNYC H PC NG TC N+ Y CTC GY+G +CE C SNPC
Sbjct: 274 EGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPC 333
Query: 357 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG--FECICPEQ 414
NGGSC + G+ C CP G+ G C CA +PC GG+C ++ G + C CP
Sbjct: 334 RNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPN 393
Query: 415 WVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGG 473
+ G+ C+ V+ C C +GG C + C C GF G +CEL +CA +PC GG
Sbjct: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
Query: 474 LCEDLADGFHCHCPQGFSGPLCEV--DVDLCEPSPCRNGARCY-NLEGD-YYCACPDDFG 529
C DL +G C CP GFSG CEV +D C SPC N A CY +L D + C CP F
Sbjct: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
Query: 530 GKNCSVP 536
G C P
Sbjct: 514 GSRCEFP 520
Score = 216 bits (551), Expect = 8e-56
Identities = 130/395 (32%), Positives = 173/395 (43%), Gaps = 64/395 (16%)
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEV--PSGFECHCPSGWSGPTCALDIDE 388
YR C D Y G NC + C N H V P G C GW+G C I
Sbjct: 171 YRVICSDNYYGDNCSRL---CKKR---NDHFGHYVCQPDG-NLSCLPGWTGEYCQQPI-- 221
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC--RGQCQHGGTCKDLVNGYQC 446
C S G C EC+C W G C N+C C+HG TC +QC
Sbjct: 222 CLSGCHEQNGYCSKPA---ECLCRPGWQGRLC----NECIPHNGCRHG-TCS---TPWQC 270
Query: 447 VCPRGFGGRHCELERDECAS-SPCHSGGLCEDLAD-GFHCHCPQGFSGPLCEVDVDLCEP 504
C G+GG C+ + + C SPC +G C + + C C G++G CE+++ C+
Sbjct: 271 TCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDS 330
Query: 505 SPCRNGARCYNLEGDYYCACPDDFGGKNC-----SVPREPC-PGGACRVIDGCGSDAGPG 558
+PCRNG C + E Y+C CP + G +C S PC GG+CR
Sbjct: 331 NPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRE----------- 379
Query: 559 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD 618
G N++C C FTG+ C + +D C PC NGG C++
Sbjct: 380 -----------------RNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP 422
Query: 619 AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF-- 676
+ C C G+ G C+ + +DC +PC G C+DL N C C G+ G+ C R
Sbjct: 423 SRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSID 482
Query: 677 QCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTC 709
C + C N TCY S DTF C CP G+ GS C
Sbjct: 483 ACASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRC 517
Score = 203 bits (517), Expect = 7e-52
Identities = 125/399 (31%), Positives = 180/399 (45%), Gaps = 60/399 (15%)
Query: 444 YQCVCPRGFGGRHCELERDECASSPCHSGG-LCEDLADGFHCHCPQGFSGPLCEVDVDLC 502
Y+ +C + G +C C H G +C+ DG + C G++G C+ +
Sbjct: 171 YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQP--DG-NLSCLPGWTGEYCQQPI--- 221
Query: 503 EPSPCRNGARCYNLEG----DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 558
C +G C+ G C C + G+ C+ E P CR
Sbjct: 222 ----CLSG--CHEQNGYCSKPAECLCRPGWQGRLCN---ECIPHNGCR------------ 260
Query: 559 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQ-PCRNGGTCIDEV 617
HG C S P + C CD G+ G +C ++++ C PC+NG TC +
Sbjct: 261 ------------HGTC-STP---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
Query: 618 D-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 676
++ C C G+ G C+ ++C +PC + G C D + ++C C G+ G C
Sbjct: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
Query: 677 QCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 734
C C NGG+C + G + C CPP + GS C K C NPC NGG C+ G S
Sbjct: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQCLNRGPS 423
Query: 735 FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC--RINIDE 792
C CR G+ G C + +DC PC +GG C D N C C GF+G C R +ID
Sbjct: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
Query: 793 CQSSPCAYGATCVDEING--YRCSCPPGRAGPRCQEVIG 829
C SSPC ATC +++ + C+CP G G RC+ +G
Sbjct: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG 522
Score = 189 bits (481), Expect = 1e-47
Identities = 118/354 (33%), Positives = 160/354 (45%), Gaps = 30/354 (8%)
Query: 516 LEGDYYCACPDDFGGKNCS---VPREPCPGGACRVIDGCGSDAGPGMPGT------AASG 566
L Y C D++ G NCS R G DG PG G SG
Sbjct: 167 LRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDG-NLSCLPGWTGEYCQQPICLSG 225
Query: 567 VCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPS 626
+G C S+P C+C G+ G C+E I CR+G TC ++C C
Sbjct: 226 CHEQNGYC-SKPA---ECLCRPGWQGRLCNECIPH---NGCRHG-TCSTP---WQCTCDE 274
Query: 627 GWEGELCDTNPNDCLP-DPCHSRGRCYDLVNDFY-CACDDGWKGKTCHSREFQCDAYTCS 684
GW G CD + N C PC + C + Y C C G+ G C +CD+ C
Sbjct: 275 GWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCR 334
Query: 685 NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV--GSGASFSCICRDG 742
NGG+C D D + C CPPG+ G C + SC +PC NGG+C GA+++C C
Sbjct: 335 NGGSCKDQEDGYHCLCPPGYYGLHCEHS-TLSCADSPCFNGGSCRERNQGANYACECPPN 393
Query: 743 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 802
+ G C + C PC NGG C++ C C PGF G C +++ +C +PCA+G
Sbjct: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
Query: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGF----GRSCWSRGTPFPHGSSWVEDCN 852
TC D NG C+CP G +G RC+ C++R T + S+ CN
Sbjct: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCN 507
Score = 95.5 bits (236), Expect = 3e-19
Identities = 68/262 (25%), Positives = 101/262 (38%), Gaps = 65/262 (24%)
Query: 198 CDENYYSATCNK---FCRPRNDFFGHYTCDQYGNKA----CMDGWMGKECKEAVCKQGCN 250
CDE + C++ +C + TC G ++ C G+ G +C+ + + N
Sbjct: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
Query: 251 LLHGGCTVPGE-----CRCSYGWQGRFCDE----CVPYPGCVHGSCVEPWQ-----CNCE 296
G + + C C G+ G C+ C P GSC E Q C C
Sbjct: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECP 391
Query: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
N+ G C+K ++ C S+ PC NGG C+N P + C C G++G CE C NPC
Sbjct: 392 PNFTGSNCEKKVDRCTSN-PCANGGQCLNRGPSRM-CRCRPGFTGTYCELHVSDCARNPC 449
Query: 357 ANGGSCHEVPSG------------------------------------------FECHCP 374
A+GG+CH++ +G F C+CP
Sbjct: 450 AHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCP 509
Query: 375 SGWSGPTCALDIDECASNPCAA 396
G+ G C + S P A
Sbjct: 510 YGFVGSRCEFPVGLPPSFPWVA 531
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 441 bits (1134), Expect = e-123
Identities = 249/767 (32%), Positives = 348/767 (45%), Gaps = 89/767 (11%)
Query: 231 CMDGWMGKECK---EAVCKQGCNLLHGGCTVPG----ECRCSYGWQGRFC---DECVPYP 280
C+ G+ G+ C+ E C G C + +C C GW G C D C P
Sbjct: 105 CLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANP 164
Query: 281 GCVHGS-CVEPW---QCNCETNWGGLLCDKDLNYCGSHH-PCTNGGTCINAEPDQYRCTC 335
CV+G C+ + QC+C + G C++D+N C PC G +C N ++C C
Sbjct: 165 -CVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTL-GSFQCLC 222
Query: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVP---SGFE-CHCPSGWSGPTCALDIDECAS 391
P G G CE C C+NGG+C +P S F C CP G+ GP C ++ D C S
Sbjct: 223 PVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVS 282
Query: 392 NPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ----CQHGGTCKDLVNGYQCV 447
+ C GGTC D +D + C+CPE W G C DV++C Q C++GGTC++ + CV
Sbjct: 283 HQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCV 342
Query: 448 CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 507
C G+GG CE D+C ++ C G C D F C CP G +G LC ++ D+C PC
Sbjct: 343 CVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPC 401
Query: 508 RNGARCYN--LEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAAS 565
A+C L G C C + G C + C + GP
Sbjct: 402 HGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDEC----------LMAQQGP-------- 443
Query: 566 GVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCP 625
C G C++ P G+F+C+C G+TG+ C + ++CL QPC G TC+D + F C CP
Sbjct: 444 SPCEHGGSCLNTP-GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCP 502
Query: 626 SGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSN 685
G EG+LC+ N+C PC + C+DL+N F C C G+ G C +C + C+N
Sbjct: 503 PGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCAN 562
Query: 686 GGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEG 745
GG C D F C C PG++G C + CL +PC G +C+ +F C+C G+ G
Sbjct: 563 GGQCQDQPGAFHCKCLPGFEGPRCQ-TEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTG 621
Query: 746 RTCTHNTNDCNPLPCYNGGICVDGVNWFRC-------ECAP------------------- 779
+ C C P C IC D + C CAP
Sbjct: 622 QLC--EVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVC 679
Query: 780 --GFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRS--CW 835
G+ GP+C + C S+PCA+G TC + +GY C+CP G GP C E + S C
Sbjct: 680 DVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCL 739
Query: 836 SRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAG----QPEALSAQCPL--- 888
+ G+ P + C + S +C PC G +P S C +
Sbjct: 740 NGGSCNPSPGGYYCTCPPSH-TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQ 798
Query: 889 GQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARL 935
G RC K C PC C + P CL +G+ +C L
Sbjct: 799 GPRCEGKLRPSCADSPCRNRATC-QDSPQGPRCLCPTGYTGGSCQTL 844
Score = 437 bits (1123), Expect = e-122
Identities = 263/802 (32%), Positives = 341/802 (42%), Gaps = 94/802 (11%)
Query: 221 YTCDQYGNKACMDGWMGKECKEAV--CK-QGCNLLHGGCTVPGE-----CRCSYGWQGRF 272
YTC C + W G +C E V C+ QG G T C C GW G
Sbjct: 298 YTC------LCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTS 351
Query: 273 CDE---------CVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
C+E C P C+ V + C C GLLC + + C S PC C
Sbjct: 352 CEENLDDCIAATCAPGSTCIDR--VGSFSCLCPPGRTGLLCHLE-DMCLSQ-PCHGDAQC 407
Query: 324 -INAEPDQYRCTCPDGYSGRNCEKAEHACTS-----NPCANGGSCHEVPSGFECHCPSGW 377
N C C GYSG C + C +PC +GGSC P F C CP G+
Sbjct: 408 STNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGY 467
Query: 378 SGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGT 436
+G C D +EC S PC G TC+D + F C+CP G C+++ N+C C +
Sbjct: 468 TGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHAD 527
Query: 437 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 496
C DL+NG+QC+C GF G CE + DEC SSPC +GG C+D FHC C GF GP C+
Sbjct: 528 CHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587
Query: 497 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGS--- 553
+VD C PC GA C +L G ++C CP F G+ C VP C C+ C
Sbjct: 588 TEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPL--CAPNLCQPKQICKDQKD 645
Query: 554 -------DAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP 606
D PG + C HG C SC+CD G+TG C + C+ P
Sbjct: 646 KANCLCPDGSPGCAPPEDNCTCH-HGHCQRS-----SCVCDVGWTGPECEAELGGCISAP 699
Query: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 666
C +GGTC + + C CP+G+ G C C PC + G C +YC C
Sbjct: 700 CAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH 759
Query: 667 KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGG 726
G C + C + C NGGTC + TF C C G++G C SC +PC N
Sbjct: 760 TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRA 819
Query: 727 TCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 786
TC S C+C G+ G +C + C PC C+ F C C G+ GP C
Sbjct: 820 TCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLC 879
Query: 787 RINIDECQ----------SSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSC 834
+ + CQ SS C G CVD Y C CPPG G CQ+ + R C
Sbjct: 880 NLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPC 939
Query: 835 WSRGTPFPHGSSWVEDCNSCRCLDG--RRDCSKVW--CGWKPCLLAG----QPEALSAQC 886
+ T S ++ C+C G ++CSK C +PC G +P C
Sbjct: 940 QNGATCMAQPSGYL-----CQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCAC 994
Query: 887 P---LGQRCLEKAPGQCLRPPCEAWGECGAEEPPST---PCLPRSGHLDNNC-------- 932
P +G RC E +CL PC G + CLP GH C
Sbjct: 995 PPGFVGLRC-EGDVDECLDQPCHPTGTAACHSLANAFYCQCLP--GHTGQWCEVEIDPCH 1051
Query: 933 ARLTLHFNRDHVPQGTTVGAIC 954
++ H G+ +G IC
Sbjct: 1052 SQPCFHGGTCEATAGSPLGFIC 1073
Score = 421 bits (1082), Expect = e-117
Identities = 271/872 (31%), Positives = 355/872 (40%), Gaps = 151/872 (17%)
Query: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGG- 255
RC FC R H +CM GW G++C+ ++GG
Sbjct: 113 RCQAKLEDPCPPSFCSKRGRC--HIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGV 170
Query: 256 --CTVPG-ECRCSYGWQGRFCD----ECVPYPG-CVHG-SC---VEPWQCNCETNWGGLL 303
T P +C C G++G C+ EC PG C G SC + +QC C G
Sbjct: 171 CLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPR 230
Query: 304 CDKDLNYCGSHHPCTNGGTC-INAEPDQ--YRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
C+ C C+NGGTC + E D + C CP G+ G +CE C S+ C NGG
Sbjct: 231 CELRAGPC-PPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGG 289
Query: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASN---PCAAGGTCVDQVDGFECICPEQWVG 417
+C + + C CP W+G C+ D+DEC + C GGTC + F C+C W G
Sbjct: 290 TCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGG 349
Query: 418 ATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC- 475
+C+ +++DC C G TC D V + C+CP G G C LE D C S PCH C
Sbjct: 350 TSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCS 408
Query: 476 -EDLADGFHCHCPQGFSGPLCEVDVDLC-----EPSPCRNGARCYNLEGDYYCACPDDFG 529
L C C G+SGP C D+D C PSPC +G C N G + C CP +
Sbjct: 409 TNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYT 468
Query: 530 GKNCSVPREPC------PGGAC-RVIDGCGSDAGPGMPG--------TAASGVCGPHGRC 574
G C C PG C ++ PG+ G AS C H C
Sbjct: 469 GSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADC 528
Query: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
G F CIC GF+GT C E+ID+C PC NGG C D+ AF C C G+EG C
Sbjct: 529 HDLLNG-FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQ 587
Query: 635 TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGK------------------------- 669
T ++CL DPC C DL F+C C G+ G+
Sbjct: 588 TEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKA 647
Query: 670 ------------------TCHSREFQCDAYTCSNG---------------------GTCY 690
TCH Q + C G GTCY
Sbjct: 648 NCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCY 707
Query: 691 DSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTH 750
+ C CP G+ G TC+ + ++C PC+NGG+C S + C C G C
Sbjct: 708 PQPSGYNCTCPTGYTGPTCS-EEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQT 766
Query: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINI-DECQSSPCAYGATCVDEIN 809
+T+ C PC+NGG CV+ F C CA GF GP C + C SPC ATC D
Sbjct: 767 STDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQ 826
Query: 810 GYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCG 869
G RC CP G G CQ ++ C + P P S ++ S CL C + W G
Sbjct: 827 GPRCLCPTGYTGGSCQTLMDL---CAQK--PCPRNSHCLQTGPSFHCL-----CLQGWTG 876
Query: 870 ------WKPCLLAGQPEAL--SAQCPLGQRCLEKAP-------------------GQCLR 902
C A + + S+ C G C++ P C
Sbjct: 877 PLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCES 936
Query: 903 PPCEAWGECGAEEPPSTPCLPRSGHLDNNCAR 934
PC+ C A +P C G+ NC++
Sbjct: 937 RPCQNGATCMA-QPSGYLCQCAPGYDGQNCSK 967
Score = 398 bits (1023), Expect = e-110
Identities = 237/687 (34%), Positives = 308/687 (44%), Gaps = 113/687 (16%)
Query: 311 CGSH-HPCTNGGTCINAE-------------------PD--------------------- 329
CGS PC NGGTC++ PD
Sbjct: 28 CGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAP 87
Query: 330 ------------QYRCTCPDGYSGRNCE-KAEHACTSNPCANGGSCHEVPSGF-ECHCPS 375
+ CTC G++G C+ K E C + C+ G CH SG +C C
Sbjct: 88 LGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMP 147
Query: 376 GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC---RGQCQ 432
GW+G C L D C++NPC GG C+ +C CP + G C+ DVN+C G C
Sbjct: 148 GWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCP 206
Query: 433 HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD---GFH-CHCPQ 488
G +C + + +QC+CP G G CEL C C +GG C+ + + FH C CP
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
Query: 489 GFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVI 548
GF GP CEV+ D C C+NG C + Y C CP+ + G +CS +
Sbjct: 267 GFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCS-----------EDV 315
Query: 549 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCR 608
D C + G P G C G+F C+C SG+ GT C EN+DDC+ C
Sbjct: 316 DECETQ---GPPHCRNGGTC-------QNSAGSFHCVCVSGWGGTSCEENLDDCIAATCA 365
Query: 609 NGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRC--YDLVNDFYCACDDGW 666
G TCID V +F C CP G G LC + CL PCH +C L C C G+
Sbjct: 366 PGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPCHGDAQCSTNPLTGSTLCLCQPGY 424
Query: 667 KGKTCHSREFQC-----DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNP 721
G TCH +C C +GG+C ++ +F C CPPG+ GS C A ++ CL P
Sbjct: 425 SGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE-ADHNECLSQP 483
Query: 722 CVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF 781
C G TC+ A+F C+C G EG+ C TN+C PC N C D +N F+C C PGF
Sbjct: 484 CHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGF 543
Query: 782 AGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPF 841
+G C +IDEC+SSPCA G C D+ + C C PG GPRCQ + C S P
Sbjct: 544 SGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVD---ECLS--DPC 598
Query: 842 PHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCL-EKAPGQC 900
P G+S ++ + CL C + G L P C Q C +K C
Sbjct: 599 PVGASCLDLPGAFFCL-----CPSGFTG----QLCEVPLCAPNLCQPKQICKDQKDKANC 649
Query: 901 LRPPCEAWGECGAEEPPSTPCLPRSGH 927
L P G G PP C GH
Sbjct: 650 LCPD----GSPGC-APPEDNCTCHHGH 671
Score = 395 bits (1014), Expect = e-109
Identities = 246/778 (31%), Positives = 340/778 (43%), Gaps = 106/778 (13%)
Query: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCT-VPG--ECRCSYGWQGRFC----DECVPYPG 281
C+ G+ G C+E + C+ G C PG C+C G++G C DEC+ P
Sbjct: 539 CLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPC 598
Query: 282 CVHGSCVE---PWQCNCETNWGGLLCDKDL---NYCGSHHPCTN---------------- 319
V SC++ + C C + + G LC+ L N C C +
Sbjct: 599 PVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGC 658
Query: 320 -----GGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374
TC + + C C G++G CE C S PCA+GG+C+ PSG+ C CP
Sbjct: 659 APPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCP 718
Query: 375 SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQH 433
+G++GPTC+ ++ C S PC GG+C G+ C CP G CQ + C C +
Sbjct: 719 TGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFN 778
Query: 434 GGTCKDLVNGYQCVCPRGFGGRHCELE-RDECASSPCHSGGLCEDLADGFHCHCPQGFSG 492
GGTC + + C+C GF G CE + R CA SPC + C+D G C CP G++G
Sbjct: 779 GGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTG 838
Query: 493 PLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 552
C+ +DLC PC + C ++C C + G C++P C A
Sbjct: 839 GSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALS------ 892
Query: 553 SDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT 612
G S +C G CV G ++ C C GF G+ C ++++ C +PC+NG T
Sbjct: 893 -------QGIDVSSLCHNGGLCVDS-GPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGAT 944
Query: 613 CIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCH 672
C+ + + C C G++G+ C + C PCH+ G C F+CAC G+ G C
Sbjct: 945 CMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCE 1004
Query: 673 SREFQCDAYTCSNGGT--CYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTC-- 728
+C C GT C+ + F C C PG G C V + C PC +GGTC
Sbjct: 1005 GDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEV-EIDPCHSQPCFHGGTCEA 1063
Query: 729 -VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF---RCECAPGFAGP 784
GS F C C G+EG TC+H C C++GG+C+ RC C G+ GP
Sbjct: 1064 TAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGP 1123
Query: 785 DCRI--NIDEC-QSSPCAYGATCVDEIN----GYRCSCPPGRAGPRCQEVIGFGRSCWSR 837
DC C SPC Y +C + G+RCSCP GPRCQ+
Sbjct: 1124 DCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQK----------P 1173
Query: 838 GTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWK--PCLLAGQPEALSAQCPLGQRC-LE 894
G G S C++ CS W C L G P+ CP RC L
Sbjct: 1174 GAKGCEGRSGDGACDA--------GCSGPGGNWDGGDCSL-GVPDPWKG-CPSHSRCWLL 1223
Query: 895 KAPGQCLRPPCEAWGEC-----GAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQG 947
GQC P C++ EC E PP+ C P D C HF+ H +G
Sbjct: 1224 FRDGQC-HPQCDS-EECLFDGYDCETPPA--CTPA---YDQYCHD---HFHNGHCEKG 1271
Score = 40.4 bits (93), Expect = 0.010
Identities = 47/186 (25%), Positives = 64/186 (34%), Gaps = 42/186 (22%)
Query: 230 ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPG----CVHG 285
AC+ G+ G +C +GC C G C + G G PG C H
Sbjct: 1115 ACLSGYGGPDCLTPPAPKGCG-PPSPCLYNGSCSETTGLGG---------PGFRCSCPHS 1164
Query: 286 S----CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP----- 336
S C +P CE G CD + G + +GG C PD ++ CP
Sbjct: 1165 SPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGN---WDGGDCSLGVPDPWK-GCPSHSRC 1220
Query: 337 -----DGYSGRNCEKAE-----HACTSNPC---ANGGSCHEVPSGFECHCPSGWSGPTCA 383
DG C+ E + C + P A CH+ HC G + C
Sbjct: 1221 WLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHD--HFHNGHCEKGCNTAECG 1278
Query: 384 LDIDEC 389
D +C
Sbjct: 1279 WDGGDC 1284
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 377 bits (967), Expect = e-104
Identities = 221/752 (29%), Positives = 315/752 (41%), Gaps = 98/752 (13%)
Query: 228 NKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC---------DECVP 278
N +C W E + +C GC+ L + C W G +EC
Sbjct: 521 NSSC---WFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQH 577
Query: 279 YPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP-- 336
C + +C+C ++ G LC +++YC +H + G C+ + C C
Sbjct: 578 EAVCKDE--INRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALS---HNCNCSGL 632
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396
Y CE C S C NG + + F C G+ G C +DIDECAS+PC
Sbjct: 633 QRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKN 692
Query: 397 GGTCVDQ--------------VDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTCKDLV 441
G TC+DQ VDGF C+C +VG C+ D++DC C+H TCKDL
Sbjct: 693 GATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLH 752
Query: 442 NGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 501
YQCVC + G CE E +EC +PC + C DL + C C G++G C +++
Sbjct: 753 LSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINE 812
Query: 502 CEPSPCRNGARCYN--LEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGM 559
C+ PC NG C+ + G + C CP + G+ C C
Sbjct: 813 CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD------------------ 854
Query: 560 PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDA 619
C + C++ N CIC F G C ++ DCL C++ G C D V+
Sbjct: 855 ---LLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNN 911
Query: 620 FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 679
FRC C G+ G LC+ N+C +PC + G C DL N F+C C+ + G C +C
Sbjct: 912 FRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCK 971
Query: 680 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCIC 739
C + C D + C C PG+ G C + CL PC++ G C+ ++C C
Sbjct: 972 ISPCLDEENCVYRTDGYNCLCAPGYTGINCEI-NLDECLSEPCLHDGVCIDGINHYTCDC 1030
Query: 740 RDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCA 799
+ G+ G C N NDC PC +G C + +N + C C C+I I++C S PC
Sbjct: 1031 KSGFFGTHCETNANDCLSNPCLHGR-CTELINEYPCSCDADGTSTQCKIKINDCTSIPCM 1089
Query: 800 YGATCVDEINGYRCSCPPGRAGPRCQEVI---------------------GFGRSCWSRG 838
C +G+ C CP G G C++ I G G + R
Sbjct: 1090 NEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRC 1149
Query: 839 TPFPHGSSW---VEDCNSCRCLDGRRDCS--------KVWCGWKPCLLAGQPEALSAQCP 887
P G + +C+S CL G DC K GW + E + C
Sbjct: 1150 LPGFSGQFCEININECSSSPCLHG-ADCEDHINGYVCKCQPGWSGHHCENELECIPNSC- 1207
Query: 888 LGQRCLEKAPGQ-CLRPP----CEAWGECGAE 914
+ + C+E PG CL P C CG E
Sbjct: 1208 VHELCMENEPGSTCLCTPGFMTCSIGLLCGDE 1239
Score = 313 bits (801), Expect = 8e-85
Identities = 192/629 (30%), Positives = 274/629 (43%), Gaps = 78/629 (12%)
Query: 223 CDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC 282
C++ +C+ G+ K C++A+ C LL C C + GRF C+P GC
Sbjct: 388 CEKDYPCSCISGFTEKNCEKAI--DHCKLLSINCLNEEWC---FNIIGRFKYVCIP--GC 440
Query: 283 VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGR 342
C W L + L YCG T G C + P Q+ G++G
Sbjct: 441 TKNPC---WFLK-----NVYLIHQHLCYCG----VTFHGICQDKGPAQFEYVWQLGFAGS 488
Query: 343 NCEKAE-----HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAG 397
EK + + + C + P C W +I CA G
Sbjct: 489 EGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSC---WFPHEGTKEI-------CANG 538
Query: 398 GTCVDQVDG--FECICPEQWVGAT-CQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGG 454
+C+ + D + +C +W G + +D +CQH CKD +N +C C + G
Sbjct: 539 CSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIG 598
Query: 455 RHCELERDECASSPCHS-GGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARC 513
R C + D C + S GLC L+ +C Q + +CE+D + C+ + C+NG
Sbjct: 599 RLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTS 658
Query: 514 YNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 573
+L G ++ C F G C + + C AS C
Sbjct: 659 THLRGYFFRKCVPGFKGTQCEIDIDEC-----------------------ASHPCKNGAT 695
Query: 574 CVSQPGG-------------NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAF 620
C+ QPG FSC+C+ G+ G C ++IDDC+ C + TC D ++
Sbjct: 696 CIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSY 755
Query: 621 RCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDA 680
+C C S WEG C+ N+C +PC + C DL + C C GW G+ C +CD+
Sbjct: 756 QCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDS 815
Query: 681 YTCSNGGTCYDS--GDTFRCACPPGWKGSTCAVAKN-SSCLPNPCVNGGTCVG-SGASFS 736
C NGG C++S F C CPP + G C N L NPC N TC+ A+
Sbjct: 816 DPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQH 875
Query: 737 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 796
CICR+ +EG+ C + DC L C + G C D VN FRC C PGF+G C I I+EC S
Sbjct: 876 CICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSE 935
Query: 797 PCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
PC TCVD N + C+C P GP C+
Sbjct: 936 PCKNNGTCVDLTNRFFCNCEPEYHGPFCE 964
Score = 276 bits (705), Expect = 1e-73
Identities = 167/547 (30%), Positives = 231/547 (42%), Gaps = 63/547 (11%)
Query: 194 IRVRCDENYYSATCNKFCRPRN---DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQG 248
+ +RC+++ N C + D Y C C+ W G C++ CK
Sbjct: 726 VGIRCEQDIDDCILNA-CEHNSTCKDLHLSYQC------VCLSDWEGNFCEQESNECKMN 778
Query: 249 CNLLHGGCT---VPGECRCSYGWQGRFC----DECVPYPGCVHGSCVE---PWQ--CNCE 296
+ CT C C+ GW G+ C +EC P G C E P Q C C
Sbjct: 779 PCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCP 838
Query: 297 TNWGGLLCDKDLNYCGS-HHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNP 355
+ G C + N C H+PC N TC+ C C + + G+NCE C
Sbjct: 839 PLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS 898
Query: 356 CANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQW 415
C + G C ++ + F C C G+SG C ++I+EC+S PC GTCVD + F C C ++
Sbjct: 899 CQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEY 958
Query: 416 VGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGL 474
G C+LDVN C+ C C +GY C+C G+ G +CE+ DEC S PC G+
Sbjct: 959 HGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGV 1018
Query: 475 CEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS 534
C D + + C C GF G CE + + C +PC +G RC L +Y C+C D C
Sbjct: 1019 CIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHG-RCTELINEYPCSCDADGTSTQCK 1077
Query: 535 VPREPCPGGACRVIDGCGSDAGP-------GMPGTAA-------------SGVCGPHGRC 574
+ C C C A G G S +C G C
Sbjct: 1078 IKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGIC 1137
Query: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
V PG F C C GF+G +C NI++C PC +G C D ++ + C C GW G C+
Sbjct: 1138 VDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Query: 635 TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD 694
N +C+P+ C C + C C G+ TCS G C D
Sbjct: 1198 -NELECIPNSC-VHELCMENEPGSTCLCTPGF--------------MTCSIGLLCGDEIR 1241
Query: 695 TFRCACP 701
C P
Sbjct: 1242 RITCLTP 1248
Score = 231 bits (588), Expect = 4e-60
Identities = 181/747 (24%), Positives = 276/747 (36%), Gaps = 116/747 (15%)
Query: 271 RFCDECVPYPGCV-HGSCV-EPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI 324
+FC E + C HG C+ E W C+C+ + G C ++L+ C S PC N G+CI
Sbjct: 172 QFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYC-QELDAC-SFKPCKNNGSCI 229
Query: 325 NA----EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGP 380
N + Y C C ++G+NC + C + C +G + + F C C +SGP
Sbjct: 230 NKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGP 289
Query: 381 TCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKD 439
C + C S G C + + CP+ + DV++ CQ+G C
Sbjct: 290 FCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIK 349
Query: 440 LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV 499
+ N C+C F C+ + C S P + C+ + C C GF+ CE +
Sbjct: 350 ISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAI 409
Query: 500 DLCE--PSPCRNGARCYNLEG-------------------------DYYCACPDDFGG-- 530
D C+ C N C+N+ G + C C F G
Sbjct: 410 DHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGIC 469
Query: 531 ---------------------KNCSVPREP-------CPGGACRVIDGCGSDAGPGMPGT 562
+ C + C A V D +++ P
Sbjct: 470 QDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHE 529
Query: 563 AASGVCGPHGRCVSQPGGN-FSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFR 621
+C C+S+ + +C + G EN D C++ C DE++ R
Sbjct: 530 GTKEICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
Query: 622 CFCPSGWEGELCDTNPNDCLPDPCHS-RGRCYDLVNDFYCACDDGWKGKTCHSREFQCDA 680
C C + G LC N + CL + S G C L ++ C+ ++ C C +
Sbjct: 590 CSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCKS 649
Query: 681 YTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS------ 734
+C NG T F C PG+KG+ C + + C +PC NG TC+ +
Sbjct: 650 ASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDE-CASHPCKNGATCIDQPGNYFCQCV 708
Query: 735 --------FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 786
FSC+C G+ G C + +DC C + C D ++C C + G C
Sbjct: 709 PPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFC 768
Query: 787 RINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSS 846
+EC+ +PC +TC D YRC C G G C E I
Sbjct: 769 EQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEI------------------ 810
Query: 847 WVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAP-GQCLRPPC 905
+C+S C++G C + + GQ L GQ C ++ L PC
Sbjct: 811 --NECDSDPCMNGGL-CHE-------STIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPC 860
Query: 906 EAWGECGAEEPPSTPCLPRSGHLDNNC 932
C A + C+ R NC
Sbjct: 861 RNNSTCLALVDANQHCICREEFEGKNC 887
Score = 73.2 bits (178), Expect = 1e-12
Identities = 33/77 (42%), Positives = 44/77 (57%), Gaps = 3/77 (3%)
Query: 678 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV-GSGASFS 736
C TC NGG C +G TF C C P W G+TC ++ SCL N C++ C+ S+S
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC--NQSVSCLNNLCLHQSLCIPDQSFSYS 2936
Query: 737 CICRDGWEGRTCTHNTN 753
C+C GW GR C + T+
Sbjct: 2937 CLCTLGWVGRYCENKTS 2953
Score = 63.2 bits (152), Expect = 1e-09
Identities = 42/116 (36%), Positives = 48/116 (41%), Gaps = 11/116 (9%)
Query: 648 RGRCYDLV--NDFYCACDDGWKGKT---CHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
RG DL N + D+ GK CH C + C N GTC + C CP
Sbjct: 2306 RGCILDLQVNNKEFFIIDEARHGKNIENCHVP--WCAHHLCRNNGTCISDNENLFCECPR 2363
Query: 703 GWKGSTCAVAKNSSCLPNPCVNGGTCV-GSGASFSCICRDGWEGRTCTHNTNDCNP 757
+ G C A SC NPC NG TCV SG C+C G G CT N P
Sbjct: 2364 LYSGKLCQFA---SCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 62.4 bits (150), Expect = 3e-09
Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 671 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC-----LPNPCVNG 725
CH+ C C NGGTC +SG + C C GWKGS C S+C P+ C G
Sbjct: 2609 CHASP--CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETV-STCDPEHDPPHHCSRG 2665
Query: 726 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 757
TC+ ++C C G G C + +P
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCEQALSISDP 2697
Score = 62.0 bits (149), Expect = 3e-09
Identities = 29/90 (32%), Positives = 41/90 (45%), Gaps = 11/90 (12%)
Query: 380 PTCALDIDECASNPCAA-----GGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ---- 430
P + +C ++PC+ GGTC++ C C W G+ C V+ C +
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP 2659
Query: 431 --CQHGGTCKDLVNGYQCVCPRGFGGRHCE 458
C G TC L +GY C CP G G +CE
Sbjct: 2660 HHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 60.1 bits (144), Expect = 1e-08
Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 10/101 (9%)
Query: 336 PDGY--SGRNCEKAEHA-CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDEC--- 389
P+G+ +GR+ + + C+ C NGG+C E + C+C +GW G C + C
Sbjct: 2596 PEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPE 2655
Query: 390 --ASNPCAAGGTCVDQVDGFECICPEQWVGATCQ--LDVND 426
+ C+ G TC+ G+ C CP G C+ L ++D
Sbjct: 2656 HDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISD 2696
Score = 59.3 bits (142), Expect = 2e-08
Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 5/83 (6%)
Query: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP-----CAYGATCV 805
+ + C+ + C NGG C++ C C G+ G C + C C+ GATC+
Sbjct: 2610 HASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI 2669
Query: 806 DEINGYRCSCPPGRAGPRCQEVI 828
+GY C CP G G C++ +
Sbjct: 2670 SLPHGYTCFCPLGTTGIYCEQAL 2692
Score = 59.3 bits (142), Expect = 2e-08
Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 2/73 (2%)
Query: 350 ACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCV-DQVDGFE 408
AC N C NGG C + F C C W+G TC + C +N C C+ DQ +
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYS 2936
Query: 409 CICPEQWVGATCQ 421
C+C WVG C+
Sbjct: 2937 CLCTLGWVGRYCE 2949
Score = 58.9 bits (141), Expect = 3e-08
Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 5/77 (6%)
Query: 715 SSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCN-----PLPCYNGGICVDG 769
S C C NGGTC+ SG S C C GW+G CT + C+ P C G C+
Sbjct: 2612 SPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL 2671
Query: 770 VNWFRCECAPGFAGPDC 786
+ + C C G G C
Sbjct: 2672 PHGYTCFCPLGTTGIYC 2688
Score = 56.2 bits (134), Expect = 2e-07
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 706 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 765
GS ++C N C NGG C +G +FSC C W G TC + + N L C + +
Sbjct: 2868 GSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNL-CLHQSL 2926
Query: 766 CVDGVNW-FRCECAPGFAGPDC 786
C+ ++ + C C G+ G C
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYC 2948
Score = 55.8 bits (133), Expect = 2e-07
Identities = 26/71 (36%), Positives = 30/71 (42%), Gaps = 1/71 (1%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTC-KDLVNGYQCV 447
C N C GG C F C C W G TC V+ C H C D Y C+
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCL 2938
Query: 448 CPRGFGGRHCE 458
C G+ GR+CE
Sbjct: 2939 CTLGWVGRYCE 2949
Score = 55.5 bits (132), Expect = 3e-07
Identities = 28/79 (35%), Positives = 38/79 (48%), Gaps = 8/79 (10%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC-----TSNPCANGGSCHEVPSGFEC 371
C NGGTCI + Y C C G+ G C + C + C+ G +C +P G+ C
Sbjct: 2619 CGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 372 HCPSGWSGPTC--ALDIDE 388
CP G +G C AL I +
Sbjct: 2678 FCPLGTTGIYCEQALSISD 2696
Score = 55.1 bits (131), Expect = 4e-07
Identities = 32/88 (36%), Positives = 45/88 (51%), Gaps = 5/88 (5%)
Query: 760 CYNGGICV-DGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEIN-GYRCSCPP 817
C N G C+ D N F CEC ++G C+ C+++PC GATCV + C CP
Sbjct: 2344 CRNNGTCISDNENLF-CECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTDIVCLCPY 2400
Query: 818 GRAGPRCQEVIGFGRSCWSRGTPFPHGS 845
GR+GP C + I + +S F + S
Sbjct: 2401 GRSGPLCTDAINITQPRFSGTDAFGYTS 2428
Score = 55.1 bits (131), Expect = 4e-07
Identities = 36/106 (33%), Positives = 49/106 (46%), Gaps = 11/106 (10%)
Query: 571 HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEG 630
H R + P G+ ++G + CH + C C NGGTCI+ + C C +GW+G
Sbjct: 2589 HFRGLGNPEGH----PNAGRSVGQCHAS--PCSLMKCGNGGTCIESGTSVYCNCTTGWKG 2642
Query: 631 ELCDTNPNDCLP--DPCH--SRG-RCYDLVNDFYCACDDGWKGKTC 671
C + C P DP H SRG C L + + C C G G C
Sbjct: 2643 SFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYC 2688
Score = 54.7 bits (130), Expect = 5e-07
Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 8/70 (11%)
Query: 285 GSCVEPWQ---CNCETNWGGLLCDKDLNYCGSHHP----CTNGGTCINAEPDQYRCTCPD 337
G+C+E CNC T W G C + ++ C H C+ G TCI+ P Y C CP
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL-PHGYTCFCPL 2681
Query: 338 GYSGRNCEKA 347
G +G CE+A
Sbjct: 2682 GTTGIYCEQA 2691
Score = 53.9 bits (128), Expect = 9e-07
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG-DYYC 522
CA C + G C + C CP+ +SG LC+ CE +PC NGA C G D C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396
Query: 523 ACPDDFGGKNCS 534
CP G C+
Sbjct: 2397 LCPYGRSGPLCT 2408
Score = 53.5 bits (127), Expect = 1e-06
Identities = 29/89 (32%), Positives = 35/89 (39%), Gaps = 7/89 (7%)
Query: 633 CDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD-----AYTCSNGG 687
C +P C C + G C + YC C GWKG C CD + CS G
Sbjct: 2609 CHASP--CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGA 2666
Query: 688 TCYDSGDTFRCACPPGWKGSTCAVAKNSS 716
TC + C CP G G C A + S
Sbjct: 2667 TCISLPHGYTCFCPLGTTGIYCEQALSIS 2695
Score = 53.1 bits (126), Expect = 2e-06
Identities = 25/75 (33%), Positives = 38/75 (50%), Gaps = 3/75 (4%)
Query: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD-GFHCHCPQG 489
C++ GTC C CPR + G+ C+ C ++PC +G C + C CP G
Sbjct: 2344 CRNNGTCISDNENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTDIVCLCPYG 2401
Query: 490 FSGPLCEVDVDLCEP 504
SGPLC +++ +P
Sbjct: 2402 RSGPLCTDAINITQP 2416
Score = 52.4 bits (124), Expect = 3e-06
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 568 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP-----CRNGGTCIDEVDAFRC 622
CG G C+ + G + C C +G+ G++C E + C + C G TCI + C
Sbjct: 2619 CGNGGTCI-ESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 623 FCPSGWEGELCD 634
FCP G G C+
Sbjct: 2678 FCPLGTTGIYCE 2689
Score = 52.0 bits (123), Expect = 3e-06
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 5/75 (6%)
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPS-----PCRNGARCYNLEG 518
C+ C +GG C + +C+C G+ G C V C+P C GA C +L
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 519 DYYCACPDDFGGKNC 533
Y C CP G C
Sbjct: 2674 GYTCFCPLGTTGIYC 2688
Score = 51.2 bits (121), Expect = 6e-06
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 7/83 (8%)
Query: 598 NIDDCLG-----QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY 652
N+ DC G CRNGG C F C C W G C+ + + CL + C + C
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCI 2928
Query: 653 -DLVNDFYCACDDGWKGKTCHSR 674
D + C C GW G+ C ++
Sbjct: 2929 PDQSFSYSCLCTLGWVGRYCENK 2951
Score = 50.8 bits (120), Expect = 8e-06
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 744 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGAT 803
+G C +NT C NGG C F C C P +AG C ++ C ++ C + +
Sbjct: 2875 DGTACGYNT-------CRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSL 2926
Query: 804 CV-DEINGYRCSCPPGRAGPRCQEVIGF 830
C+ D+ Y C C G G C+ F
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYCENKTSF 2954
Score = 50.4 bits (119), Expect = 1e-05
Identities = 28/87 (32%), Positives = 36/87 (41%), Gaps = 4/87 (4%)
Query: 341 GRNCEKAEHA-CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT 399
G+N E C + C N G+C C CP +SG C C +NPC G T
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGAT 2385
Query: 400 CVDQV-DGFECICPEQWVGATCQLDVN 425
CV + C+CP G C +N
Sbjct: 2386 CVPKSGTDIVCLCPYGRSGPLCTDAIN 2412
Score = 50.1 bits (118), Expect = 1e-05
Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 5/81 (6%)
Query: 430 QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP-----CHSGGLCEDLADGFHC 484
+C +GGTC + C C G+ G C C C G C L G+ C
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 485 HCPQGFSGPLCEVDVDLCEPS 505
CP G +G CE + + +PS
Sbjct: 2678 FCPLGTTGIYCEQALSISDPS 2698
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 5/78 (6%)
Query: 595 CHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDL 654
CH + C CRN GTCI + + C CP + G+LC C +PC + C
Sbjct: 2334 CH--VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGATCVPK 2389
Query: 655 V-NDFYCACDDGWKGKTC 671
D C C G G C
Sbjct: 2390 SGTDIVCLCPYGRSGPLC 2407
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 552 GSDAGPGMPGTAAS-GVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNG 610
GS+ G GTA C G C G FSC C + G C++++ CL C +
Sbjct: 2868 GSNVGD-CDGTACGYNTCRNGGECTVN-GTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQ 2924
Query: 611 GTCI-DEVDAFRCFCPSGWEGELCD 634
CI D+ ++ C C GW G C+
Sbjct: 2925 SLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 43.9 bits (102), Expect = 0.001
Identities = 31/92 (33%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV--DGVNWFR 774
C + C N GTC+ + C C + G+ C + C PC NG CV G +
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS--CENNPCGNGATCVPKSGTD-IV 2395
Query: 775 CECAPGFAGPDC--RINIDECQ-SSPCAYGAT 803
C C G +GP C INI + + S A+G T
Sbjct: 2396 CLCPYGRSGPLCTDAINITQPRFSGTDAFGYT 2427
Score = 43.1 bits (100), Expect = 0.002
Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 10/74 (13%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTC-----KDLVNG 443
CA + C GTC+ + C CP + G CQ + C +G TC D+V
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCE-NNPCGNGATCVPKSGTDIV-- 2395
Query: 444 YQCVCPRGFGGRHC 457
C+CP G G C
Sbjct: 2396 --CLCPYGRSGPLC 2407
Score = 41.6 bits (96), Expect = 0.005
Identities = 26/77 (33%), Positives = 32/77 (41%), Gaps = 12/77 (15%)
Query: 280 PGCVH------GSCV---EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ 330
P C H G+C+ E C C + G LC C ++PC NG TC+
Sbjct: 2337 PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASC-ENNPCGNGATCVPKSGTD 2393
Query: 331 YRCTCPDGYSGRNCEKA 347
C CP G SG C A
Sbjct: 2394 IVCLCPYGRSGPLCTDA 2410
Score = 40.0 bits (92), Expect = 0.013
Identities = 27/104 (25%), Positives = 35/104 (33%), Gaps = 24/104 (23%)
Query: 499 VDLCEPSPCR-----NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGS 553
V C SPC NG C YC C + G C+ + C
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT-----------ETVSTCDP 2654
Query: 554 DAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 597
+ P C C+S P G ++C C G TG YC +
Sbjct: 2655 EHDP-------PHHCSRGATCISLPHG-YTCFCPLGTTGIYCEQ 2690
Score = 40.0 bits (92), Expect = 0.013
Identities = 25/84 (29%), Positives = 33/84 (39%), Gaps = 15/84 (17%)
Query: 237 GKECKEAVCKQGCNLLHGGCTVPG---ECRCSYGWQGRFCDECVPYPG--CVHGSCVEP- 290
G C C+ G G CTV G CRC W G C++ V C+H S P
Sbjct: 2876 GTACGYNTCRNG-----GECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPD 2930
Query: 291 ----WQCNCETNWGGLLCDKDLNY 310
+ C C W G C+ ++
Sbjct: 2931 QSFSYSCLCTLGWVGRYCENKTSF 2954
Score = 39.3 bits (90), Expect = 0.023
Identities = 20/47 (42%), Positives = 23/47 (48%), Gaps = 5/47 (10%)
Query: 464 CASSPCHSGGLCED--LADG---FHCHCPQGFSGPLCEVDVDLCEPS 505
C CH+GG C L+ G F C CP F+G CE D L PS
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPS 2149
Score = 39.3 bits (90), Expect = 0.023
Identities = 23/102 (22%), Positives = 35/102 (34%), Gaps = 25/102 (24%)
Query: 499 VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 558
V C CRN C + + +C CP + GK C
Sbjct: 2336 VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF----------------------- 2372
Query: 559 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 600
+ + CG CV + G + C+C G +G C + I+
Sbjct: 2373 --ASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN 2412
Score = 38.9 bits (89), Expect = 0.030
Identities = 21/100 (21%), Positives = 34/100 (34%), Gaps = 24/100 (24%)
Query: 496 EVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDA 555
+ D C + CRNG C + C C D+ G C+
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN--------------------- 2911
Query: 556 GPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 595
+ + +C C+ ++SC+C G+ G YC
Sbjct: 2912 ---QSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 37.7 bits (86), Expect = 0.066
Identities = 18/68 (26%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
+ C C +W G C++ ++ ++ C + CI + Y C C G+ GR CE
Sbjct: 2897 FSCRCLPDWAGNTCNQSVSCL--NNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSF 2954
Query: 351 CTSNPCAN 358
T+ N
Sbjct: 2955 STAKFMGN 2962
Score = 37.7 bits (86), Expect = 0.066
Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 5/49 (10%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFCD 274
C+ W G C ++V LH +P + C C+ GW GR+C+
Sbjct: 2901 CLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 36.2 bits (82), Expect = 0.19
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 6/54 (11%)
Query: 317 CTNGGTC----INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP 366
C NGGTC +++ ++C CP ++GR CEK A P NG S E+P
Sbjct: 2108 CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK--DAGLFFPSFNGNSYLELP 2159
Score = 35.8 bits (81), Expect = 0.25
Identities = 19/54 (35%), Positives = 25/54 (46%), Gaps = 11/54 (20%)
Query: 410 ICPEQWVGATCQLDVNDCRGQCQHGGTCKDL-----VNGYQCVCPRGFGGRHCE 458
+ P + CQ DV C +GGTC + + +QC CP F GR CE
Sbjct: 2093 VSPSVAAPSVCQQDV------CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
Score = 35.4 bits (80), Expect = 0.33
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 5/44 (11%)
Query: 347 AEHACTSNPCANGGSCHEV--PSG---FECHCPSGWSGPTCALD 385
A C + C NGG+CH + SG F+C CP ++G C D
Sbjct: 2099 APSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142
Score = 34.3 bits (77), Expect = 0.73
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 7/65 (10%)
Query: 704 WKGSTCAVAKNSSCLPNPCVNGGTC----VGSG-ASFSCICRDGWEGRTCTHNTNDCNPL 758
W + +VA S C + C NGGTC + SG SF C C + GR C +
Sbjct: 2090 WTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLF--F 2147
Query: 759 PCYNG 763
P +NG
Sbjct: 2148 PSFNG 2152
Score = 33.5 bits (75), Expect = 1.2
Identities = 19/71 (26%), Positives = 29/71 (40%), Gaps = 2/71 (2%)
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY-NLEGDYYC 522
C + C +GG C F C C ++G C V C + C + + C + Y C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 523 ACPDDFGGKNC 533
C + G+ C
Sbjct: 2938 LCTLGWVGRYC 2948
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 364 bits (935), Expect = e-100
Identities = 214/669 (31%), Positives = 286/669 (42%), Gaps = 86/669 (12%)
Query: 268 WQGRFCDECVPYPGCVH--------------GSCVEP-------WQCNCETNWGGLLCDK 306
W R D V GC H G C++ + C+C + + G C
Sbjct: 251 WAFRIDDAQVRVGGCGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHL 310
Query: 307 DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP 366
D+N C S PC NGGTC + + +RC CP G+ G CE A+ C + C +GG C
Sbjct: 311 DVNECASQ-PCQNGGTCTHGI-NSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVEN 368
Query: 367 SGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD--- 423
C C +G++G C +D+D+C+ +PC GG+CVD V + C+C E + G C+
Sbjct: 369 GSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHP 428
Query: 424 VNDC--RGQCQHGGTCKDLVNGYQCVCPRGFGGRHC-ELERDECASSPCHSGGLCEDLAD 480
V D C +GGTC D GY C CP GF G C E D+C C +GG C A+
Sbjct: 429 VPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLG-AN 484
Query: 481 GFHCHCPQGFSGPLCEVDVDLCE---PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 537
C CP GF G LCE ++ + C +G C G Y C C D + S+P
Sbjct: 485 TTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASH-SLPS 543
Query: 538 ----EPC-PGGACRVIDGC----------GSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 582
+PC GG+C D G P +SG C G C + GG +
Sbjct: 544 PCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTC-KEAGGEY 602
Query: 583 SCICDSGFTGTYCH-ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
C C FTG +C D C PC NGGTC + ++C CP G+ G C+ P+ C
Sbjct: 603 HCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCF 662
Query: 642 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDA--------------------- 680
PC + G C D DF+C C G+ G+ C + E C
Sbjct: 663 RSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQA-EVDCGPPEEVKHATLRFNGTRLGAVAL 721
Query: 681 YTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICR 740
Y C G + + R P G + C PC++GG+C A + C+C
Sbjct: 722 YACDRGYSL-SAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCS 780
Query: 741 DGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAY 800
G+EG C ++C PC NGG C + + C C GF G C +D C SSPC +
Sbjct: 781 TGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQH 840
Query: 801 GATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLD 858
G C Y C CP G C+ V F C RG S +SC C
Sbjct: 841 GGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGS-----HSCTCKV 895
Query: 859 G--RRDCSK 865
G DC+K
Sbjct: 896 GYTGEDCAK 904
Score = 286 bits (732), Expect = 8e-77
Identities = 180/619 (29%), Positives = 250/619 (40%), Gaps = 139/619 (22%)
Query: 221 YTCDQYGNKACMDGWMGK-------ECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC 273
YTC +C+ G+ G+ EC C+ G HG + C+C G+ G C
Sbjct: 295 YTC------SCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSF--RCQCPAGFGGPTC 346
Query: 274 DEC---VPYPGCVHGSCVEPWQ----CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 326
+ C HG + C C+ + G C+ D++ C S PC NGG+C++
Sbjct: 347 ETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDC-SPDPCLNGGSCVDL 405
Query: 327 EPDQYRCTCPDGYSGRNCEKAEH----ACTSNPCANGGSCH--------EVPSGFE---- 370
+ Y C C + + G CE +H AC S PC NGG+C E P GF
Sbjct: 406 VGN-YTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDC 464
Query: 371 -----------------------CHCPSGWSGPTCALDI--------------------- 386
C CP G+ G C +I
Sbjct: 465 RERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHG 524
Query: 387 ------------------DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQ-LDVNDC 427
C S+PC GG+C D + C CP + G C+ + C
Sbjct: 525 GSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLC 584
Query: 428 R-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELER-DECASSPCHSGGLCEDLADGFHCH 485
G C++GGTCK+ Y C CP F GRHCE+ + D CAS PCH+GG C + C
Sbjct: 585 SSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCD 644
Query: 486 CPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP---- 541
CP GFSG CE+ C SPC NG C + + D++C C + G+ C + P
Sbjct: 645 CPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEV 704
Query: 542 --------GGACRVIDGCGSDAGPGMPGTAASGVCGPHG------------RCVSQP--- 578
G + D G + + VC PHG C SQP
Sbjct: 705 KHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQPCLH 764
Query: 579 GGN-------FSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGE 631
GG+ + C+C +G+ G +C D+C PCRNGG+C + A+ C CP+G+ G
Sbjct: 765 GGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYVCRCPAGFVGV 824
Query: 632 LCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYD 691
C+T + C PC GRC + C C + + G C + C + C G C
Sbjct: 825 HCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLA 884
Query: 692 SGDTFRCACPPGWKGSTCA 710
S + C C G+ G CA
Sbjct: 885 SNGSHSCTCKVGYTGEDCA 903
Score = 246 bits (628), Expect = 9e-65
Identities = 151/490 (30%), Positives = 209/490 (42%), Gaps = 145/490 (29%)
Query: 221 YTCDQYGNKACMDGWMGKECKEAV-----CKQGCNLLHGGCTVPGECRCSYGWQGRFCD- 274
Y C+ C +G+MG +C+E V C+ G L T+ C+C G+ G C+
Sbjct: 451 YVCE------CPEGFMGLDCRERVPDDCECRNGGRCLGANTTL---CQCPLGFFGLLCEF 501
Query: 275 -----------------ECVPYPG---CV----------------------HGSCV---E 289
C+ + G CV GSC +
Sbjct: 502 EITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDD 561
Query: 290 PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAE- 348
+ C C + G C+K + S PC NGGTC A +Y C+CP ++GR+CE +
Sbjct: 562 SYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAG-GEYHCSCPYRFTGRHCEIGKP 620
Query: 349 HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408
+C S PC NGG+C ++C CP G+SG C + C +PC GGTC D+ F
Sbjct: 621 DSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFF 680
Query: 409 CIC-----------------PEQWVGAT------------------------------CQ 421
C C PE+ AT CQ
Sbjct: 681 CHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQ 740
Query: 422 -----------LDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPC 469
L++++CR Q C HGG+C+D V GY C+C G+ G HCELERDEC + PC
Sbjct: 741 PHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPC 800
Query: 470 HSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFG 529
+GG C +L + C CP GF G CE +VD C+ SPC++G RC + G Y C CP+ F
Sbjct: 801 RNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFF 860
Query: 530 GKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSG 589
G +C +PC S CG G C++ G+ SC C G
Sbjct: 861 GYHCETVSDPC-----------------------FSSPCGGRGYCLAS-NGSHSCTCKVG 896
Query: 590 FTGTYCHENI 599
+TG C + +
Sbjct: 897 YTGEDCAKEL 906
Score = 244 bits (622), Expect = 5e-64
Identities = 157/563 (27%), Positives = 217/563 (38%), Gaps = 114/563 (20%)
Query: 198 CDENYYSATCNKF---CRPRNDFFGHYTCDQYGNKACM--DGWMGKECK-------EAVC 245
C Y A C C P G D GN C+ + + G C+ +A
Sbjct: 375 CQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACL 434
Query: 246 KQGCNLLHGGCTVPGE----CRCSYGWQGRFCDECVPYP-GCVHGS-CV--EPWQCNCET 297
C+ +GG V + C C G+ G C E VP C +G C+ C C
Sbjct: 435 SAPCH--NGGTCVDADQGYVCECPEGFMGLDCRERVPDDCECRNGGRCLGANTTLCQCPL 492
Query: 298 NWGGLLCDKDLNY--CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNP 355
+ GLLC+ ++ C + C +GG C+ Y C C ++ + C S+P
Sbjct: 493 GFFGLLCEFEITAMPCNMNTQCPDGGYCME-HGGSYLCVCHTDHNASH--SLPSPCDSDP 549
Query: 356 CANGGSCHEVPSGFECHCPSGWSGPTCALDIDE-CASNPCAAGGTCVDQVDGFECICPEQ 414
C NGGSC + C CP G+ G C C+S PC GGTC + + C CP +
Sbjct: 550 CFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYR 609
Query: 415 WVGATCQLDVND--CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSG 472
+ G C++ D G C +GGTC + Y+C CP GF GRHCE+ C SPC +G
Sbjct: 610 FTGRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNG 669
Query: 473 GLCEDLADGFHCH-----------------------------------------CPQGFS 491
G CED F CH C +G+S
Sbjct: 670 GTCEDRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYS 729
Query: 492 ------------------GPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533
P C +++D C PC +G C + Y C C + G +C
Sbjct: 730 LSAPSRIRVCQPHGVWSEPPQC-LEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHC 788
Query: 534 SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGT 593
+ R+ C CR G C + PG + C C +GF G
Sbjct: 789 ELERDECRAHPCR-----------------------NGGSCRNLPGA-YVCRCPAGFVGV 824
Query: 594 YCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 653
+C +D C PC++GG C A+ C CP + G C+T + C PC RG C
Sbjct: 825 HCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLA 884
Query: 654 LVNDFYCACDDGWKGKTCHSREF 676
C C G+ G+ C F
Sbjct: 885 SNGSHSCTCKVGYTGEDCAKELF 907
Score = 243 bits (619), Expect = 1e-63
Identities = 157/513 (30%), Positives = 214/513 (41%), Gaps = 91/513 (17%)
Query: 465 ASSPCHSGGLC-EDLADG---FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDY 520
A PC +GG C +D G + C C GF+G C +DV+ C PC+NG C + +
Sbjct: 274 ALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSF 333
Query: 521 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 580
C CP FGG C + PC C+ HG G
Sbjct: 334 RCQCPAGFGGPTCETAQSPCDTKECQ------------------------HGGQCQVENG 369
Query: 581 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN---- 636
+ C+C +G+TG C ++DDC PC NGG+C+D V + C C ++G C+T
Sbjct: 370 SAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPV 429
Query: 637 PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTF 696
P+ CL PCH+ G C D + C C +G+ G C RE D C NGG C + T
Sbjct: 430 PDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDC--RERVPDDCECRNGGRCLGANTTL 487
Query: 697 RCACPPGWKGSTCA--VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT-N 753
C CP G+ G C + + C +GG C+ G S+ C+C +H+ +
Sbjct: 488 -CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTD---HNASHSLPS 543
Query: 754 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC-RINIDECQSSPCAYGATCVDEINGYR 812
C+ PC+NGG C + + CEC GF G C + C S PC G TC + Y
Sbjct: 544 PCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYH 603
Query: 813 CSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP 872
CSCP G C+ IG SC S P +G + +C DC
Sbjct: 604 CSCPYRFTGRHCE--IGKPDSCASG--PCHNGGTCFHYIGKYKC-----DC--------- 645
Query: 873 CLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
P S G+ C E AP C R PC G C + C ++G++ C
Sbjct: 646 ------PPGFS-----GRHC-EIAPSPCFRSPCVNGGTC-EDRDTDFFCHCQAGYMGRRC 692
Query: 933 ------------ARLTLHFNRDHVPQGTTVGAI 953
TL FN GT +GA+
Sbjct: 693 QAEVDCGPPEEVKHATLRFN------GTRLGAV 719
Score = 173 bits (438), Expect = 1e-42
Identities = 114/370 (30%), Positives = 149/370 (40%), Gaps = 78/370 (21%)
Query: 595 CHENIDDCLG-QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 653
C CL +PC NGG CID+ C +G NP+
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDD-------CVTG--------NPS--------------- 294
Query: 654 LVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAK 713
+ C+C G+ G+ CH +C + C NGGTC ++FRC CP G+ G TC A+
Sbjct: 295 ----YTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQ 350
Query: 714 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 773
S C C +GG C S C+C+ G+ G C + +DC+P PC NGG CVD V +
Sbjct: 351 -SPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNY 409
Query: 774 RCECAPGFAGPDCRINI----DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG 829
C CA F G C D C S+PC G TCVD GY C CP G G C+E +
Sbjct: 410 TCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVP 469
Query: 830 FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCL----LAGQPEALSAQ 885
C + G RCL + G+ L + P ++ Q
Sbjct: 470 DDCECRNGG----------------RCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQ 513
Query: 886 CPLGQRCLEKA-----------------PGQCLRPPCEAWGECGAEEPPSTPCLPRSGHL 928
CP G C+E P C PC G C A + T PR H
Sbjct: 514 CPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFH- 572
Query: 929 DNNCARLTLH 938
+C + H
Sbjct: 573 GKHCEKARPH 582
Score = 48.1 bits (113), Expect = 5e-05
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 11/62 (17%)
Query: 716 SCLPNPCVNGGTCVGSGASFSCICRDGWEG-----------RTCTHNTNDCNPLPCYNGG 764
+C NPC NGGTCV + SC C G++G R CT ++ P + GG
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 765 IC 766
+C
Sbjct: 1370 VC 1371
Score = 47.4 bits (111), Expect = 8e-05
Identities = 25/64 (39%), Positives = 30/64 (46%), Gaps = 12/64 (18%)
Query: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE----KAEHACT-------SNPCANGGS 361
S +PC NGGTC+ D + C C G+ GR CE K CT + P GG
Sbjct: 1312 SENPCQNGGTCVPGA-DAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGV 1370
Query: 362 CHEV 365
CH V
Sbjct: 1371 CHHV 1374
Score = 45.1 bits (105), Expect = 4e-04
Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Query: 754 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPC 798
+C+ PC NGG CV G + C+C PGF G C + + S PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353
Score = 42.4 bits (98), Expect = 0.003
Identities = 15/34 (44%), Positives = 21/34 (61%)
Query: 601 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
+C PC+NGGTC+ DA C C G++G C+
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 40.0 bits (92), Expect = 0.013
Identities = 15/34 (44%), Positives = 19/34 (55%)
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEV 497
C+ +PC +GG C AD C C GF G CE+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 39.3 bits (90), Expect = 0.023
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 11/62 (17%)
Query: 425 NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE-----------RDECASSPCHSGG 473
N CQ+GGTC + + C C GF GR CEL E + P GG
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 474 LC 475
+C
Sbjct: 1370 VC 1371
Score = 39.3 bits (90), Expect = 0.023
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 793 CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
C +PC G TCV + + C C PG G RC+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 38.9 bits (89), Expect = 0.030
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC 394
C+ NPC NGG+C C C G+ G C L + S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353
Score = 38.9 bits (89), Expect = 0.030
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQL 422
C+ NPC GGTCV D C C + G C+L
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 34.3 bits (77), Expect = 0.73
Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 11/65 (16%)
Query: 637 PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCH----------SREF-QCDAYTCSN 685
P +C +PC + G C + C C G+KG+ C +R F + A+
Sbjct: 1308 PGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWE 1367
Query: 686 GGTCY 690
GG C+
Sbjct: 1368 GGVCH 1372
Score = 31.2 bits (69), Expect = 6.2
Identities = 11/34 (32%), Positives = 16/34 (47%)
Query: 502 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 535
C +PC+NG C + C C F G+ C +
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 300 bits (767), Expect = 7e-81
Identities = 156/481 (32%), Positives = 211/481 (43%), Gaps = 61/481 (12%)
Query: 344 CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSG--PTCALDIDECASNPCAAGGTCV 401
C K C SN C N +C + +C C + C D C SNPC TCV
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 402 DQVD--GFECICPEQWVGATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 458
+ F C CP + G C+ + C + CQHGG C C+CP G+ GR CE
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 459 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG 518
++ DECASSPC +G +C+D DG+ C C G+ G C+++VD C PC+N A C N G
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206
Query: 519 DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQP 578
Y C CP ++ G NC + + C C +G
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCL------------------------NGATCQDA 242
Query: 579 GGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCP-SGWEGELCDTNP 637
G + C C GF G +C N D+C QPC +GG C+D + + C C SG+ G C+T
Sbjct: 243 LGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLM 302
Query: 638 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC-------- 689
C PCH+ C D V+++ C C G+ G C +C++ C + G C
Sbjct: 303 PLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQ 362
Query: 690 ------------YDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 737
Y + C C PG+ G C N C NPC NGGTC +++C
Sbjct: 363 YGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNE-CSSNPCQNGGTCENLPGNYTC 421
Query: 738 IC------RDGWEGRTCTHNTNDCNPLPCYNGGICV----DGVNWFRCECAPGFAGPDCR 787
C R + GR C+ C C N G C+ DG + F C C G+ G C
Sbjct: 422 HCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481
Query: 788 I 788
I
Sbjct: 482 I 482
Score = 297 bits (760), Expect = 5e-80
Identities = 158/480 (32%), Positives = 218/480 (45%), Gaps = 61/480 (12%)
Query: 304 CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSG--RNCEKAEHACTSNPCANGGS 361
C+K+ C S+ C N TC + D C+C D + ++C+ + C SNPC +
Sbjct: 27 CNKNNTRCLSNS-CQNNSTCKDFSKDN-DCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 362 CHEVPS--GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGAT 419
C P F C CP G+SG C I C N C GG C CICP + G
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Query: 420 CQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDL 478
C++D ++C CQ+G C+D ++GY C C G+ GRHC+LE DECAS PC + C +
Sbjct: 145 CEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNE 204
Query: 479 ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE 538
+ C CP +SG CE+++D C PC NGA C + G Y+C C F G +C + +
Sbjct: 205 IGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTD 264
Query: 539 PCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC-DSGFTGTYCHE 597
C AS C G CV +SC C SGFTGT+C
Sbjct: 265 EC-----------------------ASQPCLHGGLCVDGE-NRYSCNCTGSGFTGTHCET 300
Query: 598 NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND 657
+ C +PC N TC D VD + C C G+ G C+ + N+C +PC S G C +L ++
Sbjct: 301 LMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSE 360
Query: 658 --------------------FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 697
+ C C G+ G C +C + C NGGTC + +
Sbjct: 361 KQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYT 420
Query: 698 CACPPGWKGSTCAVAKNSS-----CLPNPCVNGGTCV----GSGASFSCICRDGWEGRTC 748
C CP T ++ S C C+N GTC+ FSC+C G+ G C
Sbjct: 421 CHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLC 480
Score = 274 bits (701), Expect = 3e-73
Identities = 148/478 (30%), Positives = 205/478 (42%), Gaps = 71/478 (14%)
Query: 208 NKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPGECRCSY 266
N FC N +C N C D +C C N L C + C
Sbjct: 24 NSFCNKNNTRCLSNSCQN--NSTCKDFSKDNDCS---CSDTANNLDKDCDNMKDPC---- 74
Query: 267 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 326
F + C CV+ + C C + G +C+ + CG + C +GG C +
Sbjct: 75 -----FSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNS-CQHGGIC-HQ 127
Query: 327 EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
+P C CP GY+GR CE C S+PC NG C + G+ C C G+ G C L++
Sbjct: 128 DPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV 187
Query: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQ 445
DECAS+PC TC++++ + CICP + G C+L++++C Q C +G TC+D + Y
Sbjct: 188 DECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYF 247
Query: 446 CVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCP-QGFSGPLCEVDVDLCEP 504
C C GF G HCEL DECAS PC GGLC D + + C+C GF+G CE + LC
Sbjct: 248 CDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWS 307
Query: 505 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAA 564
PC N A C + +Y C C + G C + C C+ C + G
Sbjct: 308 KPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGR-- 365
Query: 565 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI---------- 614
+ G + CIC GFTG +C E++++C PC+NGGTC
Sbjct: 366 --ITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423
Query: 615 --------------------------------------DEVDAFRCFCPSGWEGELCD 634
D F C CPSG+ G LC+
Sbjct: 424 PFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481
Score = 193 bits (490), Expect = 9e-49
Identities = 115/383 (30%), Positives = 165/383 (43%), Gaps = 28/383 (7%)
Query: 595 CHENIDDCLGQPCRNGGTCIDEVD--AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY 652
C D C PC+ TC++ +F C CP G+ G +C+T C + C G C+
Sbjct: 67 CDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICH 126
Query: 653 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVA 712
C C G+ G+ C +C + C NG C D D + C C PG++G C +
Sbjct: 127 QDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLE 186
Query: 713 KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 772
+ C +PC N TC+ ++CIC + G C ++C PC NG C D +
Sbjct: 187 VDE-CASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGA 245
Query: 773 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCP-PGRAGPRCQEVIGFG 831
+ C+CAPGF G C +N DEC S PC +G CVD N Y C+C G G C+ ++
Sbjct: 246 YFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPL- 304
Query: 832 RSCWSRGTPFPHGSSWVEDC---NSCRCLDG----RRDCSKVWCGWKPCLLAGQPEALSA 884
CWS+ H ++ ED +C C G + + C PC G+ LS+
Sbjct: 305 --CWSKPC---HNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSS 359
Query: 885 QCPLGQ-------RCLEKAPGQ-CLRPPCEAWGEC--GAEEPPSTPCLPRSGHLDNNCAR 934
+ G+ +A G C+ P C E S PC G +N
Sbjct: 360 EKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPC-QNGGTCENLPGN 418
Query: 935 LTLHFNRDHVPQGTTVGAICSGI 957
T H D++ + G CS I
Sbjct: 419 YTCHCPFDNLSRTFYGGRDCSDI 441
Score = 186 bits (473), Expect = 9e-47
Identities = 116/391 (29%), Positives = 154/391 (39%), Gaps = 122/391 (31%)
Query: 231 CMDGWMGKECKEAVCKQGCNLL-HGGCT----VPGECRCSYGWQGRFC----DECVPYP- 280
C G+ G C+ + G N HGG + C C G+ GRFC DEC P
Sbjct: 98 CPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPC 157
Query: 281 --GCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
G V ++ + C C + G CD +++ C S PC N TC+N E +Y C CP
Sbjct: 158 QNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASD-PCKNEATCLN-EIGRYTCICPHN 215
Query: 339 YSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGG 398
YSG NCE C S PC NG +C + + C C G+ G C L+ DECAS PC GG
Sbjct: 216 YSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGG 275
Query: 399 TCVD---------------------------------------QVDGFECICPEQWVGAT 419
CVD VD + C C + GA
Sbjct: 276 LCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQ 335
Query: 420 CQLDVNDCRGQ-CQHGGTCKDL--------------------VNGYQCVCPRGFGGRHCE 458
C++D+N+C CQ G C +L +GY C+C GF G HCE
Sbjct: 336 CEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCE 395
Query: 459 LERDECASSPCHSGGLCEDLADGFHCHCP------------------------------- 487
+ +EC+S+PC +GG CE+L + CHCP
Sbjct: 396 EDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGT 455
Query: 488 -----------------QGFSGPLCEVDVDL 501
G++G LCE+ L
Sbjct: 456 CIPHFQDGQHGFSCLCPSGYTGSLCEIATTL 486
Score = 177 bits (449), Expect = 5e-44
Identities = 77/195 (39%), Positives = 106/195 (54%), Gaps = 9/195 (4%)
Query: 349 HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408
+ C SNPC +GG+C ++ S + C CP GWSG C L+IDEC SNPC G C D+V +
Sbjct: 1141 NVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPC-IHGNCSDRVAAYH 1199
Query: 409 CICPEQWVGATCQLDVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELER------ 461
C C + G C++D+++C+ QC +G TC NGY C+C F G+ C R
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVC 1259
Query: 462 -DECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDY 520
+E + C++GG C + C C GF+G CE D+D C PC NG C +L +
Sbjct: 1260 GNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKF 1319
Query: 521 YCACPDDFGGKNCSV 535
C C F G+ C V
Sbjct: 1320 QCLCDVAFAGERCEV 1334
Score = 171 bits (433), Expect = 4e-42
Identities = 80/200 (40%), Positives = 113/200 (56%), Gaps = 11/200 (5%)
Query: 308 LNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPS 367
LN C S+ PC +GG C + Y C+CP G+SG++CE C SNPC + G+C + +
Sbjct: 1140 LNVCNSN-PCLHGGNCEDIY-SSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVA 1196
Query: 368 GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC---QLDV 424
+ C C G++G C +DID C S+ CA G TC+ +G+ C+C + G C +L
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256
Query: 425 NDCRGQ-----CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 479
C + C +GG C + +C+C GF G CE + DECAS PC +GGLC+DL
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLL 1316
Query: 480 DGFHCHCPQGFSGPLCEVDV 499
+ F C C F+G CEVD+
Sbjct: 1317 NKFQCLCDVAFAGERCEVDL 1336
Score = 169 bits (428), Expect = 1e-41
Identities = 83/221 (37%), Positives = 113/221 (51%), Gaps = 19/221 (8%)
Query: 422 LDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 480
L +N C C HGG C+D+ + Y C CP G+ G+HCEL DEC S+PC G C D
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVA 1196
Query: 481 GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC 540
+HC C G++G CEVD+D C+ C NGA C + Y C C +F GK C R P
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256
Query: 541 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 600
CG++ + C G C ++ C+C GFTG +C ++ID
Sbjct: 1257 TV--------CGNEK--------TNLTCYNGGNC-TEFQTELKCMCRPGFTGEWCEKDID 1299
Query: 601 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
+C PC NGG C D ++ F+C C + GE C+ + D L
Sbjct: 1300 ECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADDL 1340
Score = 159 bits (402), Expect = 2e-38
Identities = 84/259 (32%), Positives = 122/259 (47%), Gaps = 16/259 (6%)
Query: 629 EGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG--KTCHSREFQCDAYTCSNG 686
+ C+ N CL + C + C D D C+C D K C + + C + C
Sbjct: 23 KNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGS 82
Query: 687 GTCYDSGD--TFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 744
TC ++ +F C CPPG+ G+ C SC N C +GG C CIC G+
Sbjct: 83 ATCVNTPGERSFLCKCPPGYSGTICETT-IGSCGKNSCQHGGICHQDPIYPVCICPAGYA 141
Query: 745 GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 804
GR C + ++C PC NG +C DG++ + C C PG+ G C + +DEC S PC ATC
Sbjct: 142 GRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATC 201
Query: 805 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLDG--- 859
++EI Y C CP +G C+ I CWS+ P +G++ + + C C G
Sbjct: 202 LNEIGRYTCICPHNYSGVNCELEID---ECWSQ--PCLNGATCQDALGAYFCDCAPGFLG 256
Query: 860 -RRDCSKVWCGWKPCLLAG 877
+ + C +PCL G
Sbjct: 257 DHCELNTDECASQPCLHGG 275
Score = 150 bits (380), Expect = 5e-36
Identities = 65/195 (33%), Positives = 97/195 (49%), Gaps = 7/195 (3%)
Query: 602 CLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCA 661
C PC +GG C D ++ C CP GW G+ C+ N ++C +PC G C D V ++C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPC-IHGNCSDRVAAYHCT 1201
Query: 662 CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN- 720
C+ G+ G C C ++ C+NG TC + + C C + G C ++ S +
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGN 1261
Query: 721 -----PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 775
C NGG C C+CR G+ G C + ++C PC NGG+C D +N F+C
Sbjct: 1262 EKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQC 1321
Query: 776 ECAPGFAGPDCRINI 790
C FAG C +++
Sbjct: 1322 LCDVAFAGERCEVDL 1336
Score = 150 bits (379), Expect = 7e-36
Identities = 69/195 (35%), Positives = 97/195 (49%), Gaps = 9/195 (4%)
Query: 638 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 697
N C +PC G C D+ + ++C+C GW GK C +C + C +G C D +
Sbjct: 1141 NVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAYH 1199
Query: 698 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT----- 752
C C PG+ G C V ++ C + C NG TC+ +SC+C + G+ C +
Sbjct: 1200 CTCEPGYTGVNCEVDIDN-CQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258
Query: 753 --NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 810
N+ L CYNGG C + +C C PGF G C +IDEC S PC G C D +N
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318
Query: 811 YRCSCPPGRAGPRCQ 825
++C C AG RC+
Sbjct: 1319 FQCLCDVAFAGERCE 1333
Score = 142 bits (357), Expect = 2e-33
Identities = 67/179 (37%), Positives = 99/179 (55%), Gaps = 17/179 (9%)
Query: 262 CRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGSH 314
C C GW G+ C DEC P C+HG+C V + C CE + G+ C+ D++ C SH
Sbjct: 1163 CSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSH 1221
Query: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAE-------HACTSNPCANGGSCHEVPS 367
C NG TCI+ + Y C C ++G+ C ++ + T+ C NGG+C E +
Sbjct: 1222 Q-CANGATCIS-HTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQT 1279
Query: 368 GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVND 426
+C C G++G C DIDECAS+PC GG C D ++ F+C+C + G C++D+ D
Sbjct: 1280 ELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLAD 1338
Score = 125 bits (313), Expect = 3e-28
Identities = 69/235 (29%), Positives = 110/235 (46%), Gaps = 22/235 (9%)
Query: 234 GWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQC 293
G++ K +E K N + GC C + G C++ ++ S + C
Sbjct: 1115 GFINKPQEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNCED-------IYSS----YHC 1163
Query: 294 NCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTS 353
+C W G C+ +++ C S +PC +G + Y CTC GY+G NCE C S
Sbjct: 1164 SCPLGWSGKHCELNIDECFS-NPCIHGN--CSDRVAAYHCTCEPGYTGVNCEVDIDNCQS 1220
Query: 354 NPCANGGSCHEVPSGFECHCPSGWSGPTC---ALDIDECASN----PCAAGGTCVDQVDG 406
+ CANG +C +G+ C C ++G C L C + C GG C +
Sbjct: 1221 HQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTE 1280
Query: 407 FECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELE 460
+C+C + G C+ D+++C C +GG C+DL+N +QC+C F G CE++
Sbjct: 1281 LKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVD 1335
Score = 122 bits (306), Expect = 2e-27
Identities = 72/231 (31%), Positives = 99/231 (42%), Gaps = 33/231 (14%)
Query: 381 TCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTCKD 439
T L ++ C SNPC GG C D + C CP W G C+L++++C C H G C D
Sbjct: 1135 TGCLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSD 1193
Query: 440 LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC---E 496
V Y C C G+ G +CE++ D C S C +G C +G+ C C F+G C
Sbjct: 1194 RVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSR 1253
Query: 497 VDVDLCEPS----PCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 552
+ +C C NG C + + C C F G+ C + ID C
Sbjct: 1254 LPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCE-----------KDIDECA 1302
Query: 553 SDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL 603
SD P + G G+C F C+CD F G C ++ D L
Sbjct: 1303 SD--PCVNG----GLC-------QDLLNKFQCLCDVAFAGERCEVDLADDL 1340
Score = 109 bits (272), Expect = 2e-23
Identities = 46/110 (41%), Positives = 62/110 (56%), Gaps = 1/110 (0%)
Query: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776
C NPC++GG C +S+ C C GW G+ C N ++C PC +G C D V + C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAYHCT 1201
Query: 777 CAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQE 826
C PG+ G +C ++ID CQS CA GATC+ NGY C C G C++
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQ 1251
Score = 65.1 bits (157), Expect = 4e-10
Identities = 29/75 (38%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 348 EHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGF 407
+++C SNPC NGG CH F C CP+ SG C ++ C +PC G C + GF
Sbjct: 888 DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGF 946
Query: 408 ECICPEQWVGATCQL 422
ECI + G + Q+
Sbjct: 947 ECIANAVFNGQSGQI 961
Score = 61.2 bits (147), Expect = 6e-09
Identities = 28/71 (39%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 462 DECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY 521
+ C S+PCH+GG+C D F C CP SG CE +V C SPC +GA+C + +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 522 CACPDDFGGKN 532
C F G++
Sbjct: 948 CIANAVFNGQS 958
Score = 58.2 bits (139), Expect = 5e-08
Identities = 28/75 (37%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 382 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDL 440
CA D + C SNPC GG C + D F C CP G C+ +V C C HG C+ +
Sbjct: 885 CAGD-NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPV 942
Query: 441 VNGYQCVCPRGFGGR 455
+ G++C+ F G+
Sbjct: 943 LQGFECIANAVFNGQ 957
Score = 56.2 bits (134), Expect = 2e-07
Identities = 28/71 (39%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Query: 309 NYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSG 368
N C S+ PC NGG C ++ D + C+CP SG+ CE+ + C +PC +G C V G
Sbjct: 889 NSCKSN-PCHNGGVC-HSRWDDFSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQG 945
Query: 369 FECHCPSGWSG 379
FEC + ++G
Sbjct: 946 FECIANAVFNG 956
Score = 52.0 bits (123), Expect = 3e-06
Identities = 22/61 (36%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 753 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812
N C PC+NGG+C + F C C +G C + C SPC +GA C + G+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 813 C 813
C
Sbjct: 948 C 948
Score = 50.4 bits (119), Expect = 1e-05
Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Query: 425 NDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFH 483
N C+ C +GG C + + C CP G+ CE E C SPC G C+ + GF
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 484 CHCPQGFSG 492
C F+G
Sbjct: 948 CIANAVFNG 956
Score = 46.6 bits (109), Expect = 1e-04
Identities = 27/81 (33%), Positives = 33/81 (40%), Gaps = 1/81 (1%)
Query: 708 TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV 767
T A ++SC NPC NGG C FSC C G+ C C PC +G C
Sbjct: 882 TQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQ 940
Query: 768 DGVNWFRCECAPGFAGPDCRI 788
+ F C F G +I
Sbjct: 941 PVLQGFECIANAVFNGQSGQI 961
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 1/71 (1%)
Query: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659
+ C PC NGG C D F C CP+ G+ C+ C PC +C ++ F
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 660 CACDDGWKGKT 670
C + + G++
Sbjct: 948 CIANAVFNGQS 958
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 2/70 (2%)
Query: 678 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 737
C + C NGG C+ D F C+CP G C + C +PC +G C F C
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQ--WCGFSPCPHGAQCQPVLQGFEC 948
Query: 738 ICRDGWEGRT 747
I + G++
Sbjct: 949 IANAVFNGQS 958
Score = 45.4 bits (106), Expect = 3e-04
Identities = 21/71 (29%), Positives = 31/71 (43%), Gaps = 1/71 (1%)
Query: 638 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 697
N C +PCH+ G C+ +DF C+C GK C ++ C C +G C F
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQGFE 947
Query: 698 CACPPGWKGST 708
C + G +
Sbjct: 948 CIANAVFNGQS 958
Score = 44.7 bits (104), Expect = 5e-04
Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 788 INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 845
+ ++ C S+PC +G C D + Y CSCP G +G C+ I C+S P HG+
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNID---ECFS--NPCIHGN 1190
Score = 43.1 bits (100), Expect = 0.002
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 6/55 (10%)
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 845
+ C+S+PC G C + + CSCP +G C+EV W +P PHG+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEV------QWCGFSPCPHGA 937
Score = 42.0 bits (97), Expect = 0.004
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 502 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR----EPCPGGA 544
C+ +PC NG C++ D+ C+CP GK C + PCP GA
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGA 937
Score = 38.1 bits (87), Expect = 0.051
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 500 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533
D CE PC++ RC NL Y C C + G NC
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 38.1 bits (87), Expect = 0.051
Identities = 31/123 (25%), Positives = 46/123 (37%), Gaps = 15/123 (12%)
Query: 516 LEGDYYCACPDDFGGKNCSVPREPCPGGAC-------RVIDGCGSDAGPGMPGTAASGVC 568
L G ++ C D N ++ P P V GC D + S C
Sbjct: 843 LNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGD------NSCKSNPC 896
Query: 569 GPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW 628
G C S+ +FSC C + +G C E + C PC +G C + F C + +
Sbjct: 897 HNGGVCHSR-WDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFECIANAVF 954
Query: 629 EGE 631
G+
Sbjct: 955 NGQ 957
Score = 36.6 bits (83), Expect = 0.15
Identities = 14/37 (37%), Positives = 20/37 (54%)
Query: 459 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 495
+ +D C S PC S G C +L + C C + + GP C
Sbjct: 671 VRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 34.7 bits (78), Expect = 0.56
Identities = 13/32 (40%), Positives = 17/32 (53%)
Query: 640 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTC 671
C PC SRGRC +L + C C ++G C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 32.7 bits (73), Expect = 2.1
Identities = 11/32 (34%), Positives = 16/32 (50%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTC 382
C S PC + G C + ++C C + GP C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 32.3 bits (72), Expect = 2.8
Identities = 14/42 (33%), Positives = 18/42 (42%)
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGR 832
D C+S PC C++ Y+C C GP C GR
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGR 715
Score = 32.0 bits (71), Expect = 3.6
Identities = 13/34 (38%), Positives = 20/34 (58%)
Query: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
D C QPC++ G CI+ +++C C +EG C
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 31.2 bits (69), Expect = 6.2
Identities = 11/34 (32%), Positives = 17/34 (50%)
Query: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
D C S PC + G C++ ++C C + G C
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 30.8 bits (68), Expect = 8.1
Identities = 11/32 (34%), Positives = 15/32 (46%)
Query: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTC 748
C PC + G C+ S+ C C +EG C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 300 bits (767), Expect = 7e-81
Identities = 143/398 (35%), Positives = 194/398 (48%), Gaps = 41/398 (10%)
Query: 350 ACTSNPCANGGSCHEV--------------------------------PSGFECHCPSGW 377
AC S+PCA G C P+GF C+C G+
Sbjct: 41 ACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGF 100
Query: 378 SGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGT 436
GP C LDIDECAS PC G TC + D +EC CP + G TC+++V++C C HGG+
Sbjct: 101 QGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGS 160
Query: 437 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCP-QGFSGPLC 495
C D V ++CVC G+GG C+L+ DEC S PC GG C DL +GF C C G+ G C
Sbjct: 161 CLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHC 220
Query: 496 EVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDA 555
E +V C +PC + A C G + C C + G+ C V + C C+ C +
Sbjct: 221 EREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRS 280
Query: 556 GPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCID 615
P + G + G + F C C GF G C +D+C +PC NGG C D
Sbjct: 281 DPALYGGVQAAFPGAFS---FRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQD 337
Query: 616 EVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSRE 675
+ F+C CP G+ G C+ + ++CL DPC G C D V + C C + W G+ C +
Sbjct: 338 LPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQL 397
Query: 676 FQCDAYTCSNGGTC---YDSG-DTFRCACPPGWKGSTC 709
C +TC TC ++SG ++ C CPPG G C
Sbjct: 398 TGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 280 bits (717), Expect = 4e-75
Identities = 190/628 (30%), Positives = 267/628 (42%), Gaps = 106/628 (16%)
Query: 219 GHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPG-------ECRCSYGWQGR 271
G YTC + C Q C+ HG VP C C G+QG
Sbjct: 59 GGYTCGPMEPRGC-------------ATQPCH--HGALCVPQGPDPTGFRCYCVPGFQGP 103
Query: 272 FC----DECVPYPGCVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
C DEC P C HG+ + ++C+C + G+ C+ +++ C S PC +GG+C
Sbjct: 104 RCELDIDECASRP-CHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASA-PCLHGGSC 161
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP-SGWSGPTC 382
++ +RC C GY G C+ C S PCA+GG+CH++ +GF C C +G+ G C
Sbjct: 162 LDGV-GSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHC 220
Query: 383 ALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLV 441
++ ECAS PC +C++ + F C+C + G C++D ++C CQHGG C
Sbjct: 221 EREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRS 280
Query: 442 N---------------------GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 480
+ G+ C CP GF G C +E DECAS PC +GG C+DL +
Sbjct: 281 DPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPN 340
Query: 481 GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC 540
GF CHCP G++GP CE DVD C PC +G C + Y C CP+ +GG++CSV C
Sbjct: 341 GFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGC 400
Query: 541 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN-- 598
G C + C +P SGV ++ C C G G +C +N
Sbjct: 401 QGHTCPLAATC-------IP-IFESGV------------HSYVCHCPPGTHGPFCGQNTT 440
Query: 599 IDDCLGQPCR---NGGTCIDEVDAFRCFCPSGWEGELCDTNPN-------DCLPDPCHSR 648
G P + G + FR P+G DT + L S
Sbjct: 441 FSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSY 500
Query: 649 GRCYDLVNDFYCACDDG-WKG-------KTCHSREFQ--CDAYTCSNGGTCYDSGDTFRC 698
++ A +DG W T R + C A C G +
Sbjct: 501 STTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASAT 560
Query: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 758
P G + A + CL + V+G + + + G E R C PL
Sbjct: 561 PLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLL--GCERR------EQCRPL 612
Query: 759 PCYNGGICVDGVNWFRCECAPGFAGPDC 786
PC +GG CVD FRC+CA GP C
Sbjct: 613 PCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 278 bits (711), Expect = 2e-74
Identities = 138/402 (34%), Positives = 183/402 (45%), Gaps = 55/402 (13%)
Query: 453 GGRHC-ELERDECASSPCHSGGLCEDLAD---GFHCHCPQGFSGPLCEVDVDLCEPSPCR 508
GG C +E CA+ PCH G LC GF C+C GF GP CE+D+D C PC
Sbjct: 59 GGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCH 118
Query: 509 NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVC 568
+GA C NL Y C CP + G C + + C C
Sbjct: 119 HGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCL---------------------- 156
Query: 569 GPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCP-SG 627
HG G+F C+C G+ GT C ++D+C QPC +GGTC D V+ FRC C +G
Sbjct: 157 --HGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTG 214
Query: 628 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGG 687
+EG C+ +C PC C + + F C C G+ G+ C E +C + C +GG
Sbjct: 215 YEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGG 274
Query: 688 TCYDSGDT---------------------FRCACPPGWKGSTCAVAKNSSCLPNPCVNGG 726
C D F C CPPG++G+ C V + C PC+NGG
Sbjct: 275 RCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDE-CASRPCLNGG 333
Query: 727 TCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 786
C F C C DG+ G TC + ++C PC +GG C D V + C C + G DC
Sbjct: 334 HCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDC 393
Query: 787 RINIDECQSSPCAYGATCV----DEINGYRCSCPPGRAGPRC 824
+ + CQ C ATC+ ++ Y C CPPG GP C
Sbjct: 394 SVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 259 bits (661), Expect = 1e-68
Identities = 143/410 (34%), Positives = 193/410 (47%), Gaps = 58/410 (14%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATC-QLDVNDCRGQ-CQHGGTCKDL---VNG 443
CAS+PCA G C G G TC ++ C Q C HG C G
Sbjct: 42 CASDPCAPGTECQATESG----------GYTCGPMEPRGCATQPCHHGALCVPQGPDPTG 91
Query: 444 YQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE 503
++C C GF G CEL+ DECAS PCH G C +LAD + CHCP G++G CE++VD C
Sbjct: 92 FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151
Query: 504 PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP------GGACR-VIDGCGSD-A 555
+PC +G C + G + C C +GG C + + C GG C +++G D A
Sbjct: 152 SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCA 211
Query: 556 GPGMPGT--------AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPC 607
G G GT AS C + C+ + G+F C+C G++G C + D+C PC
Sbjct: 212 GTGYEGTHCEREVLECASAPCEHNASCL-EGLGSFRCLCWPGYSGELCEVDEDECASSPC 270
Query: 608 RNGGTCIDEVD---------------------AFRCFCPSGWEGELCDTNPNDCLPDPCH 646
++GG C+ D F C CP G+EG C ++C PC
Sbjct: 271 QHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCL 330
Query: 647 SRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKG 706
+ G C DL N F C C DG+ G TC +C + C +GGTC D+ + C CP W G
Sbjct: 331 NGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGG 390
Query: 707 STCAVAKNSSCLPNPCVNGGTCVG---SGA-SFSCICRDGWEGRTCTHNT 752
C+V + + C + C TC+ SG S+ C C G G C NT
Sbjct: 391 RDCSV-QLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNT 439
Score = 232 bits (592), Expect = 1e-60
Identities = 131/386 (33%), Positives = 177/386 (45%), Gaps = 48/386 (12%)
Query: 538 EPC-PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ---PGGNFSCICDSGFTGT 593
+PC PG C+ + G GP P A+ C CV Q P G F C C GF G
Sbjct: 45 DPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTG-FRCYCVPGFQGP 103
Query: 594 YCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 653
C +ID+C +PC +G TC + D + C CP G+ G C+ ++C PC G C D
Sbjct: 104 RCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLD 163
Query: 654 LVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP-PGWKGSTCAVA 712
V F C C G+ G C +C + C++GGTC+D + FRC C G++G+ C
Sbjct: 164 GVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE-R 222
Query: 713 KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD---- 768
+ C PC + +C+ SF C+C G+ G C + ++C PC +GG C+
Sbjct: 223 EVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDP 282
Query: 769 ----GVN-------------WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811
GV F C C PGF G DC + +DEC S PC G C D NG+
Sbjct: 283 ALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGF 342
Query: 812 RCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLD--GRRDCSKVW 867
+C CP G AGP C+E + C S P HG + + CRC + G RDCS
Sbjct: 343 QCHCPDGYAGPTCEEDVD---ECLS--DPCLHGGTCSDTVAGYICRCPETWGGRDCSVQL 397
Query: 868 CGWKPCLLAGQPEALSAQCPLGQRCL 893
G + CPL C+
Sbjct: 398 TGCQ-----------GHTCPLAATCI 412
Score = 173 bits (439), Expect = 8e-43
Identities = 107/321 (33%), Positives = 145/321 (45%), Gaps = 48/321 (14%)
Query: 182 HFSGHVAHLELQIRVRCDENYYSATCNKF---CRPRNDFFGHYTCDQYGNKACM--DGWM 236
H +L + C Y TC C G D G+ C+ G+
Sbjct: 118 HHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYG 177
Query: 237 GKECK---EAVCKQGCNLLHGGCT---VPG-ECRCS-YGWQGRFCD----ECVPYPGCVH 284
G C+ + Q C HGG V G C C+ G++G C+ EC P +
Sbjct: 178 GTRCQLDLDECQSQPC--AHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHN 235
Query: 285 GSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCIN-AEPDQYR-------- 332
SC+E ++C C + G LC+ D + C S PC +GG C+ ++P Y
Sbjct: 236 ASCLEGLGSFRCLCWPGYSGELCEVDEDECASS-PCQHGGRCLQRSDPALYGGVQAAFPG 294
Query: 333 -----------CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPT 381
C CP G+ G +C C S PC NGG C ++P+GF+CHCP G++GPT
Sbjct: 295 AFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPT 354
Query: 382 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDL 440
C D+DEC S+PC GGTC D V G+ C CPE W G C + + C+G C TC +
Sbjct: 355 CEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPI 414
Query: 441 ----VNGYQCVCPRGFGGRHC 457
V+ Y C CP G G C
Sbjct: 415 FESGVHSYVCHCPPGTHGPFC 435
Score = 170 bits (431), Expect = 7e-42
Identities = 116/341 (34%), Positives = 151/341 (44%), Gaps = 60/341 (17%)
Query: 637 PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ-CDAYTCSNGGTCYDSGDT 695
P+ C DPC C A + G G TC E + C C +G C G
Sbjct: 39 PSACASDPCAPGTECQ--------ATESG--GYTCGPMEPRGCATQPCHHGALCVPQGPD 88
Query: 696 ---FRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT 752
FRC C PG++G C + + C PC +G TC + C C G+ G TC
Sbjct: 89 PTGFRCYCVPGFQGPRCELDIDE-CASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEV 147
Query: 753 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812
++C PC +GG C+DGV FRC CAPG+ G C++++DECQS PCA+G TC D +NG+R
Sbjct: 148 DECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFR 207
Query: 813 CSCP-PGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWK 871
C C G G C+ + C S P H +S +E S RCL W G+
Sbjct: 208 CDCAGTGYEGTHCEREV---LECAS--APCEHNASCLEGLGSFRCL--------CWPGYS 254
Query: 872 PCLL-AGQPEALSAQCPLGQRCLEKA------------PGQ----------CLRPPCEAW 908
L + E S+ C G RCL+++ PG C PP
Sbjct: 255 GELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEG 314
Query: 909 GECGAE--EPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQG 947
+CG E E S PCL GH C L F + H P G
Sbjct: 315 ADCGVEVDECASRPCL-NGGH----CQDLPNGF-QCHCPDG 349
Score = 111 bits (278), Expect = 4e-24
Identities = 58/161 (36%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FEC 409
C +PC + G+C ++ F C C GW GP C +D C S PCA G C DG FEC
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFEC 1118
Query: 410 ICPEQWVGATCQLDV--NDC--RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECA 465
CP + G C+L V +C C G C+ C C G G+ C++ C
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 466 SSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP 506
++PC +GG C C C FSG CEV L P P
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLP 1219
Score = 107 bits (268), Expect = 5e-23
Identities = 63/182 (34%), Positives = 77/182 (42%), Gaps = 23/182 (12%)
Query: 464 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY-NLEGDYYC 522
CA SPC G C DL D F C C G+ GP CE VD C +PC G RC+ + +G + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118
Query: 523 ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 582
CP FGG C R P P C + C + G+ G P N
Sbjct: 1119 RCPPGFGGPRC---RLPVPSKECSLNVTC-------LDGSPCEG---------GSPAANC 1159
Query: 583 SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642
SC+ G G C C PC NGGTC C C + + G+ C+ LP
Sbjct: 1160 SCL--EGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLP 1217
Query: 643 DP 644
P
Sbjct: 1218 LP 1219
Score = 106 bits (265), Expect = 1e-22
Identities = 51/151 (33%), Positives = 65/151 (43%), Gaps = 2/151 (1%)
Query: 640 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCA 699
C P PC G C DL + F CAC GW+G C + C + C+ G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 700 CPPGWKGSTC--AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 757
CPPG+ G C V L C++G C G + +C C +G G+ C T C
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 758 LPCYNGGICVDGVNWFRCECAPGFAGPDCRI 788
PC NGG C C C F+G C +
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 104 bits (259), Expect = 6e-22
Identities = 54/153 (35%), Positives = 70/153 (45%), Gaps = 4/153 (2%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNG-YQCV 447
CA +PC G C D D F C C W G C+ V+ C G C +G ++C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 448 CPRGFGGRHCELE--RDECASS-PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEP 504
CP GFGG C L EC+ + C G CE + +C C +G +G C+V CE
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 505 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 537
+PC NG C G C C F G+ C V +
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEVAK 1212
Score = 102 bits (255), Expect = 2e-21
Identities = 55/151 (36%), Positives = 70/151 (46%), Gaps = 7/151 (4%)
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSG-FECHCP 374
PC + G C + D + C C G+ G CE C S PCA G CH P G FEC CP
Sbjct: 1064 PCLHDGACRDLF-DAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFECRCP 1121
Query: 375 SGWSGPTCALDI--DECASN-PCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ- 430
G+ GP C L + EC+ N C G C C C E G CQ+ C
Sbjct: 1122 PGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANP 1181
Query: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELER 461
C +GGTC+ +C+C F G+ CE+ +
Sbjct: 1182 CLNGGTCRAAGGVSECICNARFSGQFCEVAK 1212
Score = 89.0 bits (219), Expect = 3e-17
Identities = 42/112 (37%), Positives = 54/112 (48%), Gaps = 3/112 (2%)
Query: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776
C P+PC++ G C +F+C C GWEG C + + C+ PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 777 CAPGFAGPDCRINI--DECQ-SSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
C PGF GP CR+ + EC + C G+ C CSC G AG RCQ
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQ 1171
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/155 (30%), Positives = 63/155 (40%), Gaps = 4/155 (2%)
Query: 678 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 737
C C + G C D D F CAC PGW+G C A C PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCE-AHVDPCHSAPCARGRCHTHPDGRFEC 1118
Query: 738 ICRDGWEGRTCTHN--TNDCN-PLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ 794
C G+ G C + +C+ + C +G C G C C G AG C++ C+
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 795 SSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG 829
++PC G TC C C +G C+ G
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKG 1213
Score = 83.6 bits (205), Expect = 1e-15
Identities = 58/192 (30%), Positives = 72/192 (37%), Gaps = 12/192 (6%)
Query: 539 PCPGGACRVIDGCGSDAGPGMP--GTAASGVCGP----HGRCVSQPGGNFSCICDSGFTG 592
P PG A + S G P G + VC P H F+C C G+ G
Sbjct: 1029 PRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEG 1088
Query: 593 TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC--DTNPNDC-LPDPCHSRG 649
C ++D C PC G F C CP G+ G C +C L C
Sbjct: 1089 PRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGS 1148
Query: 650 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 709
C C+C +G G+ C C+A C NGGTC +G C C + G C
Sbjct: 1149 PCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Query: 710 AVAKNSSCLPNP 721
VAK LP P
Sbjct: 1209 EVAKG---LPLP 1217
Score = 83.6 bits (205), Expect = 1e-15
Identities = 46/132 (34%), Positives = 60/132 (45%), Gaps = 14/132 (10%)
Query: 755 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCS 814
C P PC + G C D + F C C PG+ GP C ++D C S+PCA G + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 815 CPPGRAGPRCQ-----EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSK 865
CPPG GPRC+ + +C G+P GS +C CL+G R
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLD-GSPCEGGS----PAANCSCLEGLAGQRCQVPT 1174
Query: 866 VWCGWKPCLLAG 877
+ C PCL G
Sbjct: 1175 LPCEANPCLNGG 1186
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/174 (27%), Positives = 63/174 (36%), Gaps = 27/174 (15%)
Query: 501 LCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMP 560
+C PSPC + C +L + CAC + G C +PC C
Sbjct: 1059 VCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPC--------------- 1103
Query: 561 GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENI--DDC-LGQPCRNGGTCIDEV 617
GRC + P G F C C GF G C + +C L C +G C
Sbjct: 1104 ---------ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGS 1154
Query: 618 DAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTC 671
A C C G G+ C C +PC + G C C C+ + G+ C
Sbjct: 1155 PAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 64.3 bits (155), Expect = 7e-10
Identities = 38/117 (32%), Positives = 54/117 (46%), Gaps = 11/117 (9%)
Query: 299 WGGLL--CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK---AEHACTS 353
WGG C +DL G H P +++P + G N +E C+
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSEL-----GGRQSWNLTAGCVSEDMCSP 813
Query: 354 NPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
+PC NGG+C + F C CP+ ++GPTCA + C PC TC + DGF C+
Sbjct: 814 DPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCV 869
Score = 55.8 bits (133), Expect = 2e-07
Identities = 26/74 (35%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 740 RDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCA 799
R W + + C+P PC+NGG C+ N F C C F GP C + C PC
Sbjct: 796 RQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCL 854
Query: 800 YGATCVDEINGYRC 813
ATC + +G+ C
Sbjct: 855 PPATCEEVPDGFVC 868
Score = 54.3 bits (129), Expect = 7e-07
Identities = 28/87 (32%), Positives = 36/87 (41%), Gaps = 9/87 (10%)
Query: 459 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG 518
+ D C+ PC +GG C + FHC CP F+GP C + C PC A C +
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPD 864
Query: 519 DYYCAC--------PDDFGGKNCSVPR 537
+ C P F G N S R
Sbjct: 865 GFVCVAEATFREGPPAAFSGHNASSGR 891
Score = 53.5 bits (127), Expect = 1e-06
Identities = 26/77 (33%), Positives = 39/77 (50%), Gaps = 2/77 (2%)
Query: 377 WSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGG 435
W+ + D C+ +PC GGTC+ + F C CP + G TC + C GQ C
Sbjct: 799 WNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPA 857
Query: 436 TCKDLVNGYQCVCPRGF 452
TC+++ +G+ CV F
Sbjct: 858 TCEEVPDGFVCVAEATF 874
Score = 53.1 bits (126), Expect = 2e-06
Identities = 76/289 (26%), Positives = 95/289 (32%), Gaps = 55/289 (19%)
Query: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 490
C HGG+C DL ++C C R G C DE ++ GG A Q
Sbjct: 614 CVHGGSCVDLWTHFRCDCARPHRGPTCA---DEIPAATFGLGG-----APSSASFLLQEL 665
Query: 491 SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVP----REPCPGGACR 546
GP V L R G D G + R PG
Sbjct: 666 PGPNLTVSFLL----------RTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAV 715
Query: 547 VIDGCGSDAGPGMP----GTAASGVCGPH----GRCV---SQP-GGNF-SCICDSGFTGT 593
V+ G D + G G H GR + SQP GG F C+ D G
Sbjct: 716 VLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDG- 774
Query: 594 YCHENID----DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 649
CH D QP GG W + + C PDPC + G
Sbjct: 775 -CHLPFFPLPLDNSSQPSELGGR-------------QSWNLTAGCVSEDMCSPDPCFNGG 820
Query: 650 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 698
C NDF+C C + G TC +++ C C TC + D F C
Sbjct: 821 TCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFVC 868
Score = 53.1 bits (126), Expect = 2e-06
Identities = 47/151 (31%), Positives = 59/151 (39%), Gaps = 29/151 (19%)
Query: 216 DFFGHYTCDQYGNKACMDGWMGKECK-------EAVCKQG-CNLLHGGCTVPGECRCSYG 267
D F + C AC GW G C+ A C +G C+ G ECRC G
Sbjct: 1073 DLFDAFAC------ACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRF---ECRCPPG 1123
Query: 268 WQGRFC------DECVPYPGCVHGSCVEPWQ----CNCETNWGGLLCDKDLNYCGSHHPC 317
+ G C EC C+ GS E C+C G C C ++ PC
Sbjct: 1124 FGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEAN-PC 1182
Query: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEKAE 348
NGGTC A C C +SG+ CE A+
Sbjct: 1183 LNGGTC-RAAGGVSECICNARFSGQFCEVAK 1212
Score = 48.9 bits (115), Expect = 3e-05
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 6/83 (7%)
Query: 675 EFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 734
E C C NGGTC + + F C CP + G TC A+ C PC+ TC
Sbjct: 808 EDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC--AQQLWCPGQPCLPPATCEEVPDG 865
Query: 735 FSCIC----RDGWEGRTCTHNTN 753
F C+ R+G HN +
Sbjct: 866 FVCVAEATFREGPPAAFSGHNAS 888
Score = 45.8 bits (107), Expect = 2e-04
Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 1/68 (1%)
Query: 708 TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV 767
T C P+PC NGGTC+ + F C C + G TC C PC C
Sbjct: 802 TAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCE 860
Query: 768 DGVNWFRC 775
+ + F C
Sbjct: 861 EVPDGFVC 868
Score = 45.8 bits (107), Expect = 2e-04
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659
D C PC NGGTC+ + F C CP+ + G C C PC C ++ + F
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFV 867
Query: 660 CACD 663
C +
Sbjct: 868 CVAE 871
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 344 CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
CE+ E C PC +GGSC ++ + F C C GPTCA +I
Sbjct: 603 CERREQ-CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 40.8 bits (94), Expect = 0.008
Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 6/53 (11%)
Query: 788 INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP 840
++ D C PC G TC+ N + C+CP GP C + + W G P
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL------WCPGQP 852
Score = 39.7 bits (91), Expect = 0.017
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
++C+ PC +G +CVD +RC C GP C + I
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 39.3 bits (90), Expect = 0.023
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 457 CELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV 499
CE R++C PC GG C DL F C C + GP C ++
Sbjct: 603 CE-RREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 38.5 bits (88), Expect = 0.039
Identities = 18/40 (45%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 671 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 710
C RE QC C +GG+C D FRC C +G TCA
Sbjct: 603 CERRE-QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA 641
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 240 bits (612), Expect = 7e-63
Identities = 97/235 (41%), Positives = 136/235 (57%), Gaps = 6/235 (2%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290
C+ G G+ + C C+L HG C G CRC GW+G C+ CV PGC HG+C +P
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
WQC C + W G CDKD + C + PC NGG C+ +Y C C G+ GR+CE+
Sbjct: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
Query: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
C +PC NGG C + F C C G+ G C +++D+C PCA G TC+D ++
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 406 GFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459
F C+CPE + G C ++++DC + CQ G C+D V+ + C+CP G+GG+ CEL
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
Score = 171 bits (433), Expect = 4e-42
Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659
DDC G C + C C GWEG C+ C+ P G C+ +
Sbjct: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
Query: 660 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 717
C C GW GK C E C + C NGG C YD G + C C PG+ G C K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
Query: 718 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 772
+PC NGG C G +F+C C G+ G C N +DC PC NG C+DG+N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
Query: 773 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
F C C GFAG C IN+D+C S PC GA C D ++ + C CP G G C+ V+
Sbjct: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
Score = 170 bits (430), Expect = 9e-42
Identities = 91/253 (35%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 425 NDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482
+DC C HG D C C G+ G HCE C P G C +
Sbjct: 27 DDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PW 75
Query: 483 HCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPREPC 540
C C G++G C+ D +C SPC+NG +C Y+ G+Y+C C F G++C PC
Sbjct: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
Query: 541 P--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598
G CR C D G + NF+C C GF G C N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARCEVN 174
Query: 599 IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF 658
+DDCL +PC NG TC+D ++ F C CP G+ G C N +DC PC RC D V+DF
Sbjct: 175 VDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234
Query: 659 YCACDDGWKGKTC 671
C C G+ GKTC
Sbjct: 235 DCLCPSGYGGKTC 247
Score = 156 bits (395), Expect = 1e-37
Identities = 87/260 (33%), Positives = 123/260 (47%), Gaps = 21/260 (8%)
Query: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE 370
C SH +G C PD C C G+ G +CE+ C P G+CH+ ++
Sbjct: 29 CSSHCDLAHG--C--CAPDG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQ 76
Query: 371 CHCPSGWSGPTCALDIDECAS-NPCAAGGTCVDQVDG-FECICPEQWVGATCQLDVNDCR 428
C C SGW+G C D C + +PC GG C+ G + C+C + G C+ C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
Query: 429 ---GQCQHGGTCKD---LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482
C++GG C+D + C C GF G CE+ D+C PC +G C D + F
Sbjct: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
Query: 483 HCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPG 542
C CP+GF+G C +++D C PC+ GARC + D+ C CP +GGK C + P P
Sbjct: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-PVPD 255
Query: 543 GACRVIDGCGSDAGPGMPGT 562
V G + +P T
Sbjct: 256 PPTTVDTPLGPTSAVVVPAT 275
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/224 (28%), Positives = 83/224 (37%), Gaps = 31/224 (13%)
Query: 726 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 785
G C G SC C GWEG C C +P G C ++C C G+AG
Sbjct: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
Query: 786 CRINIDECQS-SPCAYGATCVDEING-YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH 843
C + C + SPC G C+ + G Y C C PG G C+ G C G+P +
Sbjct: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRN 144
Query: 844 GSSWVEDCN-----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG- 889
G +D +CRCL G R + + C +PC S CP G
Sbjct: 145 GGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGF 204
Query: 890 -QRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
R C PC+ C + CL SG+ C
Sbjct: 205 AGRFCTINLDDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 240 bits (612), Expect = 7e-63
Identities = 97/235 (41%), Positives = 136/235 (57%), Gaps = 6/235 (2%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290
C+ G G+ + C C+L HG C G CRC GW+G C+ CV PGC HG+C +P
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
WQC C + W G CDKD + C + PC NGG C+ +Y C C G+ GR+CE+
Sbjct: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
Query: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
C +PC NGG C + F C C G+ G C +++D+C PCA G TC+D ++
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 406 GFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459
F C+CPE + G C ++++DC + CQ G C+D V+ + C+CP G+GG+ CEL
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
Score = 171 bits (433), Expect = 4e-42
Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 600 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 659
DDC G C + C C GWEG C+ C+ P G C+ +
Sbjct: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
Query: 660 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 717
C C GW GK C E C + C NGG C YD G + C C PG+ G C K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
Query: 718 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 772
+PC NGG C G +F+C C G+ G C N +DC PC NG C+DG+N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
Query: 773 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
F C C GFAG C IN+D+C S PC GA C D ++ + C CP G G C+ V+
Sbjct: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
Score = 170 bits (430), Expect = 9e-42
Identities = 91/253 (35%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 425 NDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482
+DC C HG D C C G+ G HCE C P G C +
Sbjct: 27 DDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ---PW 75
Query: 483 HCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPREPC 540
C C G++G C+ D +C SPC+NG +C Y+ G+Y+C C F G++C PC
Sbjct: 76 QCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPC 135
Query: 541 P--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598
G CR C D G + NF+C C GF G C N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARCEVN 174
Query: 599 IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF 658
+DDCL +PC NG TC+D ++ F C CP G+ G C N +DC PC RC D V+DF
Sbjct: 175 VDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDF 234
Query: 659 YCACDDGWKGKTC 671
C C G+ GKTC
Sbjct: 235 DCLCPSGYGGKTC 247
Score = 156 bits (395), Expect = 1e-37
Identities = 87/260 (33%), Positives = 123/260 (47%), Gaps = 21/260 (8%)
Query: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE 370
C SH +G C PD C C G+ G +CE+ C P G+CH+ ++
Sbjct: 29 CSSHCDLAHG--C--CAPDG-SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQ 76
Query: 371 CHCPSGWSGPTCALDIDECAS-NPCAAGGTCVDQVDG-FECICPEQWVGATCQLDVNDCR 428
C C SGW+G C D C + +PC GG C+ G + C+C + G C+ C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCE 136
Query: 429 ---GQCQHGGTCKD---LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 482
C++GG C+D + C C GF G CE+ D+C PC +G C D + F
Sbjct: 137 QAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRF 196
Query: 483 HCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPG 542
C CP+GF+G C +++D C PC+ GARC + D+ C CP +GGK C + P P
Sbjct: 197 SCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-PVPD 255
Query: 543 GACRVIDGCGSDAGPGMPGT 562
V G + +P T
Sbjct: 256 PPTTVDTPLGPTSAVVVPAT 275
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/224 (28%), Positives = 83/224 (37%), Gaps = 31/224 (13%)
Query: 726 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 785
G C G SC C GWEG C C +P G C ++C C G+AG
Sbjct: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
Query: 786 CRINIDECQS-SPCAYGATCVDEING-YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH 843
C + C + SPC G C+ + G Y C C PG G C+ G C G+P +
Sbjct: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRN 144
Query: 844 GSSWVEDCN-----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG- 889
G +D +CRCL G R + + C +PC S CP G
Sbjct: 145 GGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGF 204
Query: 890 -QRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
R C PC+ C + CL SG+ C
Sbjct: 205 AGRFCTINLDDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 233 bits (595), Expect = 6e-61
Identities = 243/919 (26%), Positives = 361/919 (39%), Gaps = 218/919 (23%)
Query: 173 NPEDRWKSLHFSGHVAHLELQIRV---RCDENYYSATCNKFCRPRNDFFGHYTCD---QY 226
N ++ L + G +A ++++ + CD N + + F H +
Sbjct: 1301 NIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKK 1360
Query: 227 GNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPG--ECRCSYGWQGRFCDECVPYPGCV 283
G C D EC+ + C++ H C +PG +C C GW G +C+ C
Sbjct: 1361 GTTGCTDV---DECE--IGAHNCDM-HASCLNIPGSFKCSCREGWIGNGI-KCIDLDECS 1413
Query: 284 HGS--------CVEP---WQCNCETNW--GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ 330
+G+ CV ++C C + G C D++ C + G C+N P
Sbjct: 1414 NGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCS-DVDECAENINLCENGQCLNV-PGA 1471
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTC 382
YRC C G++ R+C+ + N C G +C+ +P F C C G+ +G C
Sbjct: 1472 YRCECEMGFTPASDSRSCQDIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNC 1530
Query: 383 ALDIDECASNPCAAGGTCVDQVDGFECICPEQW----VGATC------------------ 420
DIDECA G CV+ +EC CP + G C
Sbjct: 1531 T-DIDECADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDG 1589
Query: 421 ------QLDVNDCRGQC------QHGGTCKDL--VNG--YQCVCPRGFGGRHCEL----- 459
++ V R C G C+ VN Y +CP G G R +
Sbjct: 1590 SLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILE 1649
Query: 460 ERDECASSP-CHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLC--EPSPCRNGAR 512
+ DEC P GG C + F C CPQG+ +CE D+D C P C G
Sbjct: 1650 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE-DIDECFAHPGVCGPGT- 1707
Query: 513 CYNLEGDYYCACPDDF----GGKNC----------------------------------- 533
CYN G+Y C CP ++ GG NC
Sbjct: 1708 CYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYN 1767
Query: 534 -----SVPREPC--PGGA-----CRVIDGCGSDAGPG----------MPGTAASGVCGPH 571
+ P EPC PG A C I G D G +PG A+GV
Sbjct: 1768 VGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGV---- 1823
Query: 572 GRCVSQPGGNFSCICDSGFTGT---YCHENIDDCLG--QPCRNGGTCIDEVDAFRCFCPS 626
C++Q G+F C C +GF+ E+ID+C C+ CI+ ++RC C +
Sbjct: 1824 --CINQI-GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAA 1880
Query: 627 GWE----GELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG---KTCHSREFQCD 679
G++ G D N +P+ C S G C DL + C C +G+K +T +C+
Sbjct: 1881 GFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECE 1939
Query: 680 AYTCSNGGTCYDSGDTFRCACPPGWK---GSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 736
+ C N GTC ++ ++ C C PG++ + C S G C SF
Sbjct: 1940 RHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSFK 1998
Query: 737 CICRDGWE----GRTCTHNTNDCNPLP-CYNGGICVDGVNWFRCECAPGF--AGPDCRIN 789
C+C +G+E G+ C +TN+C LP + G C + FRC C PG+ +C I+
Sbjct: 1999 CLCNEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENC-ID 2056
Query: 790 IDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSW 847
I+EC P C +G +C + G++C CPPG + GR C+ F +
Sbjct: 2057 INECDEDPNICLFG-SCTNTPGGFQCLCPPGFV------LSDNGRRCFDTRQSFCFTNFE 2109
Query: 848 VEDCNSCRCLDGRRD---CSKV-WCGW-KPCLLAGQPEALSAQ--CPLG----------- 889
C+ + + + CSK+ GW PC L + + ++ Q CP G
Sbjct: 2110 NGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTR 2169
Query: 890 ---QRCLEKAPGQCLRPPC 905
CLE +PG C C
Sbjct: 2170 EDVNECLE-SPGICSNGQC 2187
Score = 191 bits (486), Expect = 3e-48
Identities = 182/660 (27%), Positives = 260/660 (39%), Gaps = 111/660 (16%)
Query: 229 KACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC----VH 284
+ C+D M C + K C G EC C+ G F + C P P H
Sbjct: 695 RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYG-FGEPCQPCPAKNSAEFH 753
Query: 285 GSCVEPWQCNCETNWGGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY---- 339
G C ++ G+ D +D+N C G C N YRC C GY
Sbjct: 754 GLC---------SSGVGITVDGRDINECALDPDICANGICENLR-GSYRCNCNSGYEPDA 803
Query: 340 SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCA 395
SGRNC + + + G C P + C CP G+ TC DI+EC SNPC
Sbjct: 804 SGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPC- 861
Query: 396 AGGTCVDQVDGFECIC-PEQWVGATCQLDVNDCRGQCQ---HGGTCKDLVNGYQCVCPRG 451
G C + + F C C P + +T + ++ +G C C+ +NG
Sbjct: 862 VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING-------- 913
Query: 452 FGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFS---GPLCEVDVDLCE--PSP 506
L+ + CA+ G CE CP+G + G CE DV+ CE P
Sbjct: 914 -----ATLKSECCATLGAAWGSPCERCE--LDTACPRGLARIKGVTCE-DVNECEVFPGV 965
Query: 507 CRNGARCYNLEGDYYCACPD----DFGGKNCSVPR--------------EPCPGG----- 543
C NG RC N +G ++C CP+ D G+ C R P PG
Sbjct: 966 CPNG-RCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDA 1024
Query: 544 -ACRVIDGCGSDAGP-GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD 601
C V G++ PGT P G + G TG +++I++
Sbjct: 1025 CCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRG--------DVLTGRPFYKDINE 1076
Query: 602 CLGQP-CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPND-----CLPDPCHSRGRCYDLV 655
C P G C + + +F+C C SG+ ++ + N D PD C S G C +
Sbjct: 1077 CKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGS-GICVNTP 1135
Query: 656 NDFYCACDDGWKG-----KTCHS-REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGS-- 707
F C C +G++ K C E + + C GGTC ++ +F+C CP G + S
Sbjct: 1136 GSFECECFEGYESGFMMMKNCMDIDECERNPLLC-RGGTCVNTEGSFQCDCPLGHELSPS 1194
Query: 708 --TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 765
C S N C N G CV ++ C C G++ D + NGG
Sbjct: 1195 REDCVDINECSLSDNLCRN-GKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC 1253
Query: 766 ---CVDGVNWFRCECAPGFA-GPDCR--INIDECQSSP-CAYGATCVDEINGYRCSCPPG 818
C + + C C+ G+A PD R +IDEC+++P G C + YRC C G
Sbjct: 1254 DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1313
Score = 190 bits (483), Expect = 6e-48
Identities = 197/704 (27%), Positives = 278/704 (39%), Gaps = 138/704 (19%)
Query: 245 CKQGCNL-LHGGCT-VPG--ECRCSYGW----QGRFC---DECVPYPGCVHGSCVEPWQC 293
C + N+ L G CT PG +C C G+ GR C + + +G C P
Sbjct: 2060 CDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAF 2119
Query: 294 NCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEH 349
N T C K + G PC C + ++ CP G+ S + + +
Sbjct: 2120 N--TTKAKCCCSK-MPGEGWGDPCE---LCPKDDEVAFQDLCPYGHGTVPSLHDTREDVN 2173
Query: 350 ACTSNP--CANGGSCHEVPSGFECHCPSGWS----GPTCALDIDECA-SNPCAAGGTCVD 402
C +P C+NG C F C CP G++ G C +D DEC+ NPC GTC +
Sbjct: 2174 ECLESPGICSNG-QCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCG-NGTCTN 2230
Query: 403 QVDGFECICPEQWVGA---TCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 458
+ FEC C E + C+ D+N+C + C + Y+C CP G+ R +
Sbjct: 2231 VIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
Query: 459 L---ERDECASS--PCHSGGL-CEDLADGFHCHCPQGFS----GPLCEVDVDLCEPSP-- 506
+ DECA C S G+ C++L F C CP G + G C VD + C P
Sbjct: 2290 KMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGI 2348
Query: 507 CRNGARCYNLEGDYYCACPDDF----GGKNCSVPREPCPGGAC--RVIDGCGSDAGPGMP 560
C NG RC N+ G Y C C + F G C R+ G C V+ A
Sbjct: 2349 CENG-RCVNIIGSYRCECNEGFQSSSSGTECLDNRQ----GLCFAEVLQTICQMASSSRN 2403
Query: 561 GTAASGVCGPHGR--------CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP--CRNG 610
S C GR C + IC G T +ID+C P C NG
Sbjct: 2404 LVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCTNG 2463
Query: 611 GTCIDEVDAFRCFCPSGWEGELCDTNPND---CLPDPCHSRGRCYDLVNDFYCACDDGW- 666
CI+ + +FRCFC G+ ++ T+ D C P C + + C+C G+
Sbjct: 2464 -QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYV 2522
Query: 667 ---KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCV 723
GKTC + +C + C ++ F C CPPG+ A N+ C P +
Sbjct: 2523 LQEDGKTCKDLD-ECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSL 2581
Query: 724 NG--GTCVGSGASFSCICRDGWE----------------GRTCTH--------------- 750
G G C + SFSC C+ G+ C H
Sbjct: 2582 CGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHGCQNILGGYRCGCPQ 2641
Query: 751 ------------NTNDC-NPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINIDEC 793
+ N+C NP C + C + + ++C C GF+ C +++EC
Sbjct: 2642 GYIQHYQWNQCVDENECSNPNACGSAS-CYNTLGSYKCACPSGFSFDQFSSACH-DVNEC 2699
Query: 794 QSS--PCAYGATCVDEINGYRCSCPPG--RAGP-RCQEVIGFGR 832
SS PC YG C + GY C CPPG R G C +GF +
Sbjct: 2700 SSSKNPCNYG--CSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNK 2741
Score = 184 bits (468), Expect = 3e-46
Identities = 193/734 (26%), Positives = 277/734 (37%), Gaps = 155/734 (21%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHY------TC-DQYGNKAC------MDGWMGKECKEAV 244
C + YY + + C ++ F H TC + GN C M G C + +
Sbjct: 1677 CPQGYYLSEDTRICEDIDECFAHPGVCGPGTCYNTLGNYTCICPPEYMQVNGGHNCMD-M 1735
Query: 245 CKQGCNLLHGGCTVPGE---------CRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNC 295
K C + G T E C C+Y + C P C P +
Sbjct: 1736 RKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEP--------CPTPGTADF 1787
Query: 296 ETNWG---GLLCD------KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN--- 343
+T G G D D++ C G CIN + +RC CP G+S +
Sbjct: 1788 KTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCIN-QIGSFRCECPTGFSYNDLLL 1846
Query: 344 -CEKAEHACTS-NPCANGGSCHEVPSGFECHCPSGW--SGPTCALDIDECASNP-CAAGG 398
CE + N C C P + C C +G+ S +D +EC P + G
Sbjct: 1847 VCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHG 1906
Query: 399 TCVDQVDGFECICPEQWVGATCQ---LDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGR 455
CVD ++CIC + + Q +DV++C GTCK+ V Y C+C GF
Sbjct: 1907 LCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELT 1966
Query: 456 HCE--LERDECAS---SPCHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCE--P 504
H L+ DEC+S C + G C + F C C +G+ G C +D + C P
Sbjct: 1967 HNNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELTPDGKNC-IDTNECVALP 2024
Query: 505 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAA 564
C G C NLEG + C CP + K+ + C I+ C D
Sbjct: 2025 GSCSPGT-CQNLEGSFRCICPPGYEVKSEN----------CIDINECDED---------- 2063
Query: 565 SGVCGPHGRCVSQPGGNFSCICDSGFT------------GTYCHENIDD----------- 601
+C G C + PGG F C+C GF ++C N ++
Sbjct: 2064 PNIC-LFGSCTNTPGG-FQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAFNT 2121
Query: 602 ------CLGQPCRN-GGTC----IDEVDAFRCFCP--SGWEGELCDT--NPNDCLPDP-C 645
C P G C D+ AF+ CP G L DT + N+CL P
Sbjct: 2122 TKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGI 2181
Query: 646 HSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP 701
S G+C + F C C G+ G C + +C GTC + +F C C
Sbjct: 2182 CSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD-ECSIGNPCGNGTCTNVIGSFECNCN 2240
Query: 702 PGWK-GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR----------TCTH 750
G++ G + C NP + C+ + S+ C C G+ R C
Sbjct: 2241 EGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECAE 2300
Query: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINIDECQSSP--CAYGATC 804
+DC G +C + + F C C PG A G C ++ +EC++ P C G C
Sbjct: 2301 GLHDCES----RGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKPGICENG-RC 2354
Query: 805 VDEINGYRCSCPPG 818
V+ I YRC C G
Sbjct: 2355 VNIIGSYRCECNEG 2368
Score = 176 bits (447), Expect = 9e-44
Identities = 190/706 (26%), Positives = 272/706 (38%), Gaps = 157/706 (22%)
Query: 216 DFFGHYTCDQY-GNKACMDGWMGK---ECKEAVCKQG-CNLLHGGCTVPGECRCSYGWQ- 269
D G Y C + G KA D M EC+ C G C G C C G++
Sbjct: 1910 DLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKNTVGSYN----CLCYPGFEL 1965
Query: 270 --GRFC---DECVPYPG--CVHGSC---VEPWQCNCETNW----GGLLCDKDLNYCGSHH 315
C DEC + G C +G C + ++C C + G C D N C +
Sbjct: 1966 THNNDCLDIDECSSFFGQVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNECVALP 2024
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANG------GSCHEVPSGF 369
+ GTC N E +RC CP GY K+E+ N C GSC P GF
Sbjct: 2025 GSCSPGTCQNLE-GSFRCICPPGYE----VKSENCIDINECDEDPNICLFGSCTNTPGGF 2079
Query: 370 ECHCPSGW----SGPTCALDIDECASNPCAAGGTC----VDQVDGFECIC---PEQWVGA 418
+C CP G+ +G C D + G C +C C P + G
Sbjct: 2080 QCLCPPGFVLSDNGRRC-FDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGD 2138
Query: 419 TCQL----------------------------DVNDCR---GQCQHGGTCKDLVNGYQCV 447
C+L DVN+C G C +G C + ++C
Sbjct: 2139 PCELCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNECLESPGICSNG-QCINTDGSFRCE 2197
Query: 448 CPRGFG----GRHCELERDECA-SSPCHSGGLCEDLADGFHCHCPQGFS-GPL--CEVDV 499
CP G+ G C ++ DEC+ +PC G C ++ F C+C +GF GP+ CE D+
Sbjct: 2198 CPMGYNLDYTGVRC-VDTDECSIGNPC-GNGTCTNVIGSFECNCNEGFEPGPMMNCE-DI 2254
Query: 500 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGM 559
+ C +P RC N G Y C CP + + C+ +D C
Sbjct: 2255 NECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQK--------MCKDLDEC-------- 2298
Query: 560 PGTAASGV--CGPHGRCVSQPGGNFSCICDSGFT----GTYCHENIDDCLGQP--CRNGG 611
A G+ C G G F CIC G G C + ++C +P C NG
Sbjct: 2299 ----AEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE-NECRTKPGICENG- 2352
Query: 612 TCIDEVDAFRCFCPSGWEG-----ELCDTNPNDCLPDP----CHSRGRCYDLVNDFYCAC 662
C++ + ++RC C G++ E D C + C +LV C C
Sbjct: 2353 RCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCC 2412
Query: 663 DDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC--LPN 720
D G QC+ C GT ++ CP G G T C +PN
Sbjct: 2413 DGG------RGWGHQCEL--CPLPGTAQ-----YKKICPHG-PGYTTDGRDIDECKVMPN 2458
Query: 721 PCVNGGTCVGSGASFSCICRDGW----EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776
C NG C+ + SF C C+ G+ G +C + ++C+ P IC + ++C
Sbjct: 2459 LCTNG-QCINTMGSFRCFCKVGYTTDISGTSCI-DLDECSQSPKPCNYICKNTEGSYQCS 2516
Query: 777 CAPGFA----GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 818
C G+ G C+ ++DECQ+ CV+ + G+ C CPPG
Sbjct: 2517 CPRGYVLQEDGKTCK-DLDECQTKQHNCQFLCVNTLGGFTCKCPPG 2561
Score = 168 bits (425), Expect = 3e-41
Identities = 175/669 (26%), Positives = 258/669 (38%), Gaps = 131/669 (19%)
Query: 219 GHYTCDQYGNKACMDGWM----GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC- 273
G C + C GW G +C +C+ C G C+ P C CS G C
Sbjct: 85 GPNVCGSRFHSYCCPGWKTLPGGNQCIVPICRNSCG--DGFCSRPNMCTCSSGQISSTCG 142
Query: 274 ----DECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPD 329
+C C++G C C+ + G C + + G C NGG CI
Sbjct: 143 SKSIQQCSVR--CMNGGTCADDHCQCQKGYIGTYCGQPVCENG----CQNGGRCIGPN-- 194
Query: 330 QYRCTCPDGYSGRNCEKAEHACTSNPC---ANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
RC C G++G CE+ + PC N C +G C + C I
Sbjct: 195 --RCACVYGFTGPQCERDYR---TGPCFTQVNNQMCQGQLTGIVC------TKTLCCATI 243
Query: 387 DECASNPCAAGGTCVDQVD----GFECICPEQWVGATCQLDVNDCR---GQCQHGGTCKD 439
+PC C Q GF P GA CQ DV++C+ G CQ GG C +
Sbjct: 244 GRAWGHPCEM---CPAQPQPCRRGF---IPNIRTGA-CQ-DVDECQAIPGICQ-GGNCIN 294
Query: 440 LVNGYQCVCPRGFGG----RHCELERDECASSP--CHSGGLCEDLADGFHCHCPQGF--- 490
V ++C CP G + CE + DEC+ P C +G C + + C CP+G+
Sbjct: 295 TVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICETGE-CSNTVGSYFCVCPRGYVTS 352
Query: 491 -SGPLC-------------------EVDVDLCEPSPCRNGARCYNLEGDYYCACP---DD 527
G C E+ + + C RC+ + G ACP +
Sbjct: 353 TDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKMQCCCEPGRCWGI-GTIPEACPVRGSE 411
Query: 528 FGGKNC--SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR-CVSQPGGNFSC 584
+ C +P PG A G G G G + GP G + PGGN
Sbjct: 412 EYRRLCMDGLPMGGIPGSAGSRPGGTG---GNGFAPSGNGNGYGPGGTGFIPIPGGN--- 465
Query: 585 ICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDP 644
GF+ + P G T +++ ++C + N CL
Sbjct: 466 ----GFSPGVGGAGVGAGGQGPIITGLTILNQTI------------DICKHHANLCL--- 506
Query: 645 CHSRGRCYDLVNDFYCACDDGWKGKT---CHSREFQCDAYTCSNGGTCYDSGDTFRCACP 701
GRC V+ + C C+ G+K C + +C + C+NG C ++ ++ C C
Sbjct: 507 ---NGRCIPTVSSYRCECNMGYKQDANGDCIDVD-ECTSNPCTNGD-CVNTPGSYYCKCH 561
Query: 702 PGWKGSTC--AVAKNSSCLPNPCV-NGGTCVGSGASFSCICRDGWE----GRTCTHNTND 754
G++ + A C+ N + G CV + SF CIC G+E G+ C +
Sbjct: 562 AGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDEC 621
Query: 755 CNPLPCYNGGICVDGVNWFRCECAPGFA-GPDCRI--NIDECQSSPCAYGATCVDEINGY 811
C NG +C++ F+C C PGF P+ R ++DECQ+ C++ +
Sbjct: 622 TTTNMCLNG-MCINEDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGHCINSEGSF 680
Query: 812 RCSCPPGRA 820
RC CPPG A
Sbjct: 681 RCDCPPGLA 689
Score = 167 bits (423), Expect = 6e-41
Identities = 209/786 (26%), Positives = 289/786 (36%), Gaps = 207/786 (26%)
Query: 225 QYGNKACMDGWMGKECKEAVCKQGCNLLHGGCT-VPGE--CRCSYGWQG----RFC---D 274
Q N C+D EC C +G C PG C+C G+Q + C D
Sbjct: 527 QDANGDCIDV---DECTSNPCT------NGDCVNTPGSYYCKCHAGFQRTPTKQACIDID 577
Query: 275 ECVPYPG-CVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA---- 326
EC+ C +G CV +QC C G D C H CT C+N
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQCICNA---GFELTTDGKNCVDHDECTTTNMCLNGMCIN 634
Query: 327 EPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWS-GPT 381
E ++C C G+ +GR C + T C NG C F C CP G + G
Sbjct: 635 EDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNG-HCINSEGSFRCDCPPGLAVGMD 693
Query: 382 CALDIDECASNPCAAG---GTCVDQVDGF----ECIC--PEQWVGATCQ----------- 421
+ +D + C G G CV G EC C P+ G CQ
Sbjct: 694 GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753
Query: 422 -------------LDVNDCRGQ---CQHGGTCKDLVNGYQCVCPRGF----GGRHCELER 461
D+N+C C +G C++L Y+C C G+ GR+C ++
Sbjct: 754 GLCSSGVGITVDGRDINECALDPDICANG-ICENLRGSYRCNCNSGYEPDASGRNC-IDI 811
Query: 462 DEC-ASSPCHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCEPSPCRNGARCYNL 516
DEC + GLC + + C CP G+ CE D++ CE +PC NGA C N
Sbjct: 812 DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPCVNGA-CRNN 869
Query: 517 EGDYYCACP-------------DDFGG--------KNCSV-------------------- 535
G + C C D G C V
Sbjct: 870 LGSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWG 929
Query: 536 -PRE------PCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDS 588
P E CP G R+ D GVC P+GRCV+ G +F C C
Sbjct: 930 SPCERCELDTACPRGLARIKGVTCEDVNEC---EVFPGVC-PNGRCVNSKG-SFHCECPE 984
Query: 589 GFT--GT------------YCHENIDDCLGQP----------CRNG---GTCIDE----- 616
G T GT Y + D+C+ C G GT +E
Sbjct: 985 GLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEECPKPG 1044
Query: 617 VDAFRCFCPSGW----EGELCDTNP-----NDC--LPDPCHSRGRCYDLVNDFYCACDDG 665
+ CP G G++ P N+C P C + G+C + + F C C+ G
Sbjct: 1045 TKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMC-TYGKCRNTIGSFKCRCNSG 1103
Query: 666 W----KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKN----SSC 717
+ + + C + + G C ++ +F C C G++ S + KN C
Sbjct: 1104 FALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE-SGFMMMKNCMDIDEC 1162
Query: 718 LPNPCV-NGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLP--CYNGGICVDGVN 771
NP + GGTCV + SF C C G E R + N+C+ C NG CV+ +
Sbjct: 1163 ERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGK-CVNMIG 1221
Query: 772 WFRCECAPGF-AGPDCR--INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
++C C PG+ A PD + +IDEC C + Y CSC G A ++
Sbjct: 1222 TYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYA------LM 1275
Query: 829 GFGRSC 834
GRSC
Sbjct: 1276 PDGRSC 1281
Score = 57.0 bits (136), Expect = 1e-07
Identities = 38/133 (28%), Positives = 50/133 (37%), Gaps = 14/133 (10%)
Query: 693 GDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT 752
G F C PGWK + + C+ C N C C G TC +
Sbjct: 90 GSRFHSYCCPGWK----TLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKS 145
Query: 753 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 812
+ C NGG C D C+C G+ G C + E + C G C I R
Sbjct: 146 IQQCSVRCMNGGTCADD----HCQCQKGYIGTYCGQPVCE---NGCQNGGRC---IGPNR 195
Query: 813 CSCPPGRAGPRCQ 825
C+C G GP+C+
Sbjct: 196 CACVYGFTGPQCE 208
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 232 bits (591), Expect = 2e-60
Identities = 245/858 (28%), Positives = 312/858 (36%), Gaps = 216/858 (25%)
Query: 161 LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCN-----KFCRPRN 215
LL + A +N ED H+ + ++ D+ YY++ + K R R
Sbjct: 15 LLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRV 74
Query: 216 DF-----FGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQG 270
+ G T + ++ C + E C C +HG C P C+C GW G
Sbjct: 75 SYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKC--VHGRCIAPNTCQCEPGWGG 132
Query: 271 RFCD----------ECVPYPGCVHGSCVEP--WQCNCETNWGGLLCDKDL------NYCG 312
C C C +G+ P C+C + G C+ N C
Sbjct: 133 TNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCH 192
Query: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE----------KAEHACTSNPCANGGSC 362
C NG TC + + C CP GY+G CE + E C PC NGG C
Sbjct: 193 QRCQCQNGATCDHVTGE---CRCPPGYTGAFCEDLCPPGKHGPQCEQRC---PCQNGGVC 246
Query: 363 HEVPSGFECHCPSGWSGPTCALDIDE------CASN-PCAAGGTCVDQVDGFECICPEQW 415
H V EC CPSGW G C E C+ C GGTC D G +C C +
Sbjct: 247 HHVTG--ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC-DAATG-QCHCSPGY 302
Query: 416 VGATCQ----------LDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE------- 458
G CQ L C QC +GG C V+G C+C GF G CE
Sbjct: 303 TGERCQDECPVGTYGVLCAETC--QCVNGGKCYH-VSG-ACLCEAGFAGERCEARLCPEG 358
Query: 459 LERDEC-ASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPS----------PC 507
L +C PCH C C G+SG C + C P C
Sbjct: 359 LYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCN---ETCSPGFYGEACQQICSC 415
Query: 508 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA----CRVIDGCGSDAGPGMPGTA 563
+NGA C ++ G C C F G +CS PCP G C GC +DA
Sbjct: 416 QNGADCDSVTGK--CTCAPGFKGIDCST---PCPLGTYGINCSSRCGCKNDA-------- 462
Query: 564 ASGVCGP-HGRCVSQPGG---NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDA 619
VC P G C + G + S C SG G C+ L C NGG C + +D
Sbjct: 463 ---VCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCN------LTCQCLNGGAC-NTLDG 512
Query: 620 FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 679
C C GW GE C+ LP C DG G C R CD
Sbjct: 513 -TCTCAPGWRGEKCE------LP-------------------CQDGTYGLNCAER---CD 543
Query: 680 AYTCSNGGTCYDSGDTFRCACPPGWKG----STCAVAK-NSSC-LPNPCVNGGTCVGSGA 733
CS+ C+ + T C C PGW G S CA + +C LP C NG +C S
Sbjct: 544 ---CSHADGCHPT--TGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASC--SPD 596
Query: 734 SFSCICRDGWEGRTCT---------HNTNDCNPLPCYNGGIC--VDGVNWFRCECAPGFA 782
C C G+ G TC H + P ++ G C + G+ C+C PGF
Sbjct: 597 DGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL----CDCLPGFT 652
Query: 783 GPDCRINIDECQS----SPCAYGATCVDEING------YRCSCPPGRAGPRCQEVIGFGR 832
G C + C S CA TC + NG C C PG G C +
Sbjct: 653 GALCN---EVCPSGRFGKNCAGICTCTN--NGTCNPIDRSCQCYPGWIGSDCSQPC---- 703
Query: 833 SCWSRGTPFPHGSSWVEDCNS-----CRCLDGRRDCSKVWCGWK-----PCLLAGQPEAL 882
P G + + CN C DG C+ W G P G+ AL
Sbjct: 704 ------PPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCAL 757
Query: 883 SAQCPLGQRCLEKAPGQC 900
QC G C + GQC
Sbjct: 758 ICQCQNGADC-DHISGQC 774
Score = 177 bits (450), Expect = 4e-44
Identities = 185/682 (27%), Positives = 242/682 (35%), Gaps = 164/682 (24%)
Query: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQ 247
RC++ Y C++ C+ +N TCD G C G+ G C++ C+Q
Sbjct: 181 RCEQGTYGNDCHQRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQ 236
Query: 248 GCNLLHGGCT--VPGECRCSYGW----------QGRFCDECVPYPGCVHGSCVEP--WQC 293
C +GG V GEC C GW +GRF C C +G + QC
Sbjct: 237 RCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQC 296
Query: 294 NCETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE-- 345
+C + G C + C C NGG C + C C G++G CE
Sbjct: 297 HCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSG---ACLCEAGFAGERCEAR 353
Query: 346 ---------KAEHACTSNPC--ANGGSCHEVPSGFECHCPSGWSG----PTCALDI--DE 388
K + C PC N SCH P EC C GWSG TC+ +
Sbjct: 354 LCPEGLYGIKCDKRC---PCHLENTHSCH--PMSGECACKPGWSGLYCNETCSPGFYGEA 408
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVN------DCRGQC----------- 431
C G D V G +C C + G C +C +C
Sbjct: 409 CQQICSCQNGADCDSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPV 467
Query: 432 QHGGTCKDLVNGYQCV--CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 489
TCK +G C CP G G C L + C +GG C L DG C C G
Sbjct: 468 DGSCTCKAGWHGVDCSIRCPSGTWGFGCNL------TCQCLNGGACNTL-DGT-CTCAPG 519
Query: 490 FSGPLCEVD-------VDLCEPSPCRNGARCYNLEGDYYC-----------ACPDDFGGK 531
+ G CE+ ++ E C + C+ G C C + G
Sbjct: 520 WRGEKCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGP 579
Query: 532 NCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGP--HGRCVSQ----------PG 579
NCS+P G +C DG + PG GT +C P +G SQ P
Sbjct: 580 NCSLPCYCKNGASCSPDDGI-CECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPC 638
Query: 580 GNFSCICDS--GFTGTYCHENID------DCLGQ-PCRNGGTCIDEVDAFRCFCPSGWEG 630
+ + +CD GFTG C+E +C G C N GTC + +D C C GW G
Sbjct: 639 HHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTC-NPIDR-SCQCYPGWIG 696
Query: 631 ELCDT-------NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR--------- 674
C PN CH+ C D C C GW G C R
Sbjct: 697 SDCSQPCPPAHWGPNCIHTCNCHNGAFCS--AYDGECKCTPGWTGLYCTQRCPLGFYGKD 754
Query: 675 -EFQCDAYTCSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSCLPN------PCVNGG 726
C C NG C + SG +C C G+ G C S C+N
Sbjct: 755 CALICQ---CQNGADCDHISG---QCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNS 808
Query: 727 TCVGSGASFSCICRDGWEGRTC 748
TC + +C C GW+G C
Sbjct: 809 TC--DHITGTCYCSPGWKGARC 828
Score = 139 bits (350), Expect = 2e-32
Identities = 146/514 (28%), Positives = 186/514 (36%), Gaps = 116/514 (22%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA--------VCKQGC 249
C E Y C+K C P + H G AC GW G C E C+Q C
Sbjct: 355 CPEGLYGIKCDKRC-PCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQIC 413
Query: 250 NLLHGG-C-TVPGECRCSYGWQGRFCD----------ECVPYPGCVHGSCVEP--WQCNC 295
+ +G C +V G+C C+ G++G C C GC + + P C C
Sbjct: 414 SCQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTC 473
Query: 296 ETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEH 349
+ W G+ C C C NGG C + CTC G+ G CE
Sbjct: 474 KAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDGT---CTCAPGWRGEKCELPCQ 530
Query: 350 ACTSN-------PCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402
T C++ CH P+ C C GWSG C CA G C
Sbjct: 531 DGTYGLNCAERCDCSHADGCH--PTTGHCRCLPGWSGVHCD---SVCAEGRW--GPNC-- 581
Query: 403 QVDGFECICPEQWVGATCQLDVNDCRGQCQ---HGGTCKDLVNGYQCVCPRGFGGRHCEL 459
C C GA+C D C +C G TC Q +C GF G C
Sbjct: 582 ---SLPCYCKN---GASCSPDDGIC--ECAPGFRGTTC-------QRICSPGFYGHRCSQ 626
Query: 460 ERDEC--ASSPCHS-GGLCEDLAD--GFHCH--CPQGFSGPLCEVDVDLCEPSPCRNGAR 512
+C +S PCH GLC+ L G C+ CP G G C +C C N
Sbjct: 627 TCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC---AGICT---CTNNGT 680
Query: 513 CYNLEGDYYCACPDDFGGKNCSVPREP------------CPGGA-CRVIDGCGSDAGPGM 559
C + D C C + G +CS P P C GA C DG PG
Sbjct: 681 CNPI--DRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDG-ECKCTPGW 737
Query: 560 PGTAASGVC--GPHGR-----CVSQPGGNFS-----CICDSGFTGTYCHENIDD-CLGQP 606
G + C G +G+ C Q G + C C +GF G +C + G
Sbjct: 738 TGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPSGTYGYG 797
Query: 607 CR------NGGTCIDEVDAFRCFCPSGWEGELCD 634
CR N TC D + C+C GW+G CD
Sbjct: 798 CRQICDCLNNSTC-DHITG-TCYCSPGWKGARCD 829
Score = 60.5 bits (145), Expect = 1e-08
Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 41/188 (21%)
Query: 198 CDENYYSATCNKFC---RPRNDFFGHYTCDQYG-------NKACMDGWMGKECKEAV--- 244
C + A CN+ C R + G TC G + C GW+G +C +
Sbjct: 647 CLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPA 706
Query: 245 -----CKQGCNLLHGG-CTV-PGECRCSYGWQGRFCDE----------CVPYPGCVHGSC 287
C CN +G C+ GEC+C+ GW G +C + C C +G+
Sbjct: 707 HWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGAD 766
Query: 288 VE--PWQCNCETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGY 339
+ QC C T + G C++ C C N TC + C C G+
Sbjct: 767 CDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGT---CYCSPGW 823
Query: 340 SGRNCEKA 347
G C++A
Sbjct: 824 KGARCDQA 831
Score = 48.1 bits (113), Expect = 5e-05
Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQ 247
RC +Y C C+ +N CD G C G+MG+ C++ C+Q
Sbjct: 745 RCPLGFYGKDCALICQCQNGA----DCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQ 800
Query: 248 GCNLLHGGCT--VPGECRCSYGWQGRFCDE 275
C+ L+ + G C CS GW+G CD+
Sbjct: 801 ICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
>gi|153946395 tenascin C precursor [Homo sapiens]
Length = 2201
Score = 228 bits (581), Expect = 3e-59
Identities = 189/605 (31%), Positives = 247/605 (40%), Gaps = 128/605 (21%)
Query: 227 GNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVH-- 284
G C+ G+ C N GC C C GW+G C E PG H
Sbjct: 143 GAGCCLQPATGRLDTRPFCSGRGNFSTEGCG----CVCEPGWKGPNCSE-PECPGNCHLR 197
Query: 285 GSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC 344
G C++ QC C+ + G +D + C + G C+N C C +GY+G +C
Sbjct: 198 GRCIDG-QCICDDGFTG----EDCSQLACPSDCNDQGKCVNGV-----CICFEGYAGADC 247
Query: 345 EKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQV 404
+ C G+C + G C C G++G C + C +N C G CV+
Sbjct: 248 SR--EICPVPCSEEHGTCVD---GL-CVCHDGFAGDDCNKPL--CLNN-CYNRGRCVEN- 297
Query: 405 DGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDEC 464
EC+C E + G C + C C G C +NG C C GF G C + C
Sbjct: 298 ---ECVCDEGFTGEDCSELI--CPNDCFDRGRC---ING-TCYCEEGFTGEDCG--KPTC 346
Query: 465 ASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCAC 524
+ CH+ G CE+ C C +GF+G C C P+ C N RC D C C
Sbjct: 347 PHA-CHTQGRCEE----GQCVCDEGFAGVDCSEK--RC-PADCHNRGRCV----DGRCEC 394
Query: 525 PDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC 584
D F G +C + CP G C HGRCV N C
Sbjct: 395 DDGFTGADCGELK--CPNG------------------------CSGHGRCV-----NGQC 423
Query: 585 ICDSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642
+CD G+TG C + L P C + G C++ +C C G++G C + P
Sbjct: 424 VCDEGYTGEDCSQ-----LRCPNDCHSRGRCVEG----KCVCEQGFKGYDCS---DMSCP 471
Query: 643 DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
+ CH GRC VN C CDDG+ G+ C R+ D CSN G C D +C C
Sbjct: 472 NDCHQHGRC---VNGM-CVCDDGYTGEDCRDRQCPRD---CSNRGLCVDG----QCVCED 520
Query: 703 GWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYN 762
G+ G CA SC PN C G CV C+C +G+ G+ C C P C+
Sbjct: 521 GFTGPDCA---ELSC-PNDCHGQGRCVNG----QCVCHEGFMGKDCKEQR--C-PSDCHG 569
Query: 763 GGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGP 822
G CVDG +C C GF G DC C S C CV RC C G +G
Sbjct: 570 QGRCVDG----QCICHEGFTGLDC--GQHSCPSD-CNNLGQCVSG----RCICNEGYSGE 618
Query: 823 RCQEV 827
C EV
Sbjct: 619 DCSEV 623
Score = 197 bits (501), Expect = 5e-50
Identities = 181/562 (32%), Positives = 228/562 (40%), Gaps = 118/562 (20%)
Query: 368 GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC-QLDVND 426
G C C GW GP C+ EC N C G C+D +CIC + + G C QL
Sbjct: 171 GCGCVCEPGWKGPNCS--EPECPGN-CHLRGRCIDG----QCICDDGFTGEDCSQL---A 220
Query: 427 CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 486
C C G C VNG C+C G+ G C R+ C G C DG C C
Sbjct: 221 CPSDCNDQGKC---VNGV-CICFEGYAGADC--SREICPVPCSEEHGTC---VDGL-CVC 270
Query: 487 PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS--------VPRE 538
GF+G C + L + C N RC E C C + F G++CS R
Sbjct: 271 HDGFAGDDCNKPLCL---NNCYNRGRCVENE----CVCDEGFTGEDCSELICPNDCFDRG 323
Query: 539 PCPGGACRVIDG-CGSDAG-PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCH 596
C G C +G G D G P P C GRC C+CD GF G C
Sbjct: 324 RCINGTCYCEEGFTGEDCGKPTCP-----HACHTQGRCEEG-----QCVCDEGFAGVDCS 373
Query: 597 ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 656
E C C N G C+D RC C G+ G D C P+ C GRC VN
Sbjct: 374 EK--RCPAD-CHNRGRCVDG----RCECDDGFTG--ADCGELKC-PNGCSGHGRC---VN 420
Query: 657 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS 716
C CD+G+ G+ C D C + G C + +C C G+KG C+ + S
Sbjct: 421 G-QCVCDEGYTGEDCSQLRCPND---CHSRGRCVEG----KCVCEQGFKGYDCS---DMS 469
Query: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776
C PN C G CV C+C DG+ G C C P C N G+CVDG +C
Sbjct: 470 C-PNDCHQHGRCVNG----MCVCDDGYTGEDC--RDRQC-PRDCSNRGLCVDG----QCV 517
Query: 777 CAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWS 836
C GF GPDC + + C CV NG +C C G G C+E + C S
Sbjct: 518 CEDGFTGPDC---AELSCPNDCHGQGRCV---NG-QCVCHEGFMGKDCKE-----QRCPS 565
Query: 837 RGTPFPHGSSWVEDCN-SCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEK 895
DC+ RC+DG+ C + + G L GQ S LGQ C+
Sbjct: 566 -------------DCHGQGRCVDGQCICHEGFTG----LDCGQHSCPSDCNNLGQ-CVS- 606
Query: 896 APGQCLRPPCEAWGECGAEEPP 917
G+C+ + +C PP
Sbjct: 607 --GRCICNEGYSGEDCSEVSPP 626
Score = 182 bits (461), Expect = 2e-45
Identities = 152/530 (28%), Positives = 210/530 (39%), Gaps = 132/530 (24%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKA-----CMDGWMGKECKEAVCKQGCNLL 252
CD+ + C++ P + C+ G C +G+ G +C +C C+
Sbjct: 207 CDDGFTGEDCSQLACPSD-------CNDQGKCVNGVCICFEGYAGADCSREICPVPCSEE 259
Query: 253 HGGCTVPGECRCSYGWQGRFCDECVPYPGCVH-GSCVEPWQCNCETNWGG-----LLCDK 306
HG C V G C C G+ G C++ + C + G CVE +C C+ + G L+C
Sbjct: 260 HGTC-VDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVEN-ECVCDEGFTGEDCSELICPN 317
Query: 307 DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK--AEHACTSNPCANGGSCHE 364
D C + G CIN C C +G++G +C K HAC + G C E
Sbjct: 318 D---------CFDRGRCING-----TCYCEEGFTGEDCGKPTCPHACHTQ-----GRCEE 358
Query: 365 VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDV 424
+C C G++G C+ ++ C G CVD C C + + GA C
Sbjct: 359 ----GQCVCDEGFAGVDCS---EKRCPADCHNRGRCVDG----RCECDDGFTGADC--GE 405
Query: 425 NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHC 484
C C G C VNG QCVC G+ G C R + CHS G C + C
Sbjct: 406 LKCPNGCSGHGRC---VNG-QCVCDEGYTGEDCSQLR---CPNDCHSRGRCVE----GKC 454
Query: 485 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 544
C QGF G C D+ P+ C RC N C C D + G++C CP
Sbjct: 455 VCEQGFKGYDCS---DMSCPNDCHQHGRCVN----GMCVCDDGYTGEDCR--DRQCPRD- 504
Query: 545 CRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENI--DDC 602
C G CV + C+C+ GFTG C E +DC
Sbjct: 505 -----------------------CSNRGLCV-----DGQCVCEDGFTGPDCAELSCPNDC 536
Query: 603 LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN--PNDCLPDPCHSRGRCYDLVNDFYC 660
GQ G C++ +C C G+ G+ C P+D CH +GRC D C
Sbjct: 537 HGQ-----GRCVNG----QCVCHEGFMGKDCKEQRCPSD-----CHGQGRCV----DGQC 578
Query: 661 ACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 710
C +G+ G C D C+N G C RC C G+ G C+
Sbjct: 579 ICHEGFTGLDCGQHSCPSD---CNNLGQCVSG----RCICNEGYSGEDCS 621
Score = 82.4 bits (202), Expect = 2e-15
Identities = 81/265 (30%), Positives = 107/265 (40%), Gaps = 48/265 (18%)
Query: 683 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 742
CS G G C C PGWKG C+ + P C G C+ CIC DG
Sbjct: 161 CSGRGNFSTEG--CGCVCEPGWKGPNCSEPE----CPGNCHLRGRCIDG----QCICDDG 210
Query: 743 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 802
+ G C+ C P C + G CV+GV C C G+AG DC I C
Sbjct: 211 FTGEDCSQLA--C-PSDCNDQGKCVNGV----CICFEGYAGADCSREI--CPVPCSEEHG 261
Query: 803 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH-----GSSWVEDC------ 851
TCVD + C C G AG C + + +C++RG + EDC
Sbjct: 262 TCVDGL----CVCHDGFAGDDCNKPLCL-NNCYNRGRCVENECVCDEGFTGEDCSELICP 316
Query: 852 NSC----RCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEA 907
N C RC++G C + + G + C G+P A C RC E GQC+ A
Sbjct: 317 NDCFDRGRCINGTCYCEEGFTG-EDC---GKPTCPHA-CHTQGRCEE---GQCVCDEGFA 368
Query: 908 WGECGAEEPPSTPCLPRSGHLDNNC 932
+C + P+ C R +D C
Sbjct: 369 GVDCSEKRCPA-DCHNRGRCVDGRC 392
Score = 58.9 bits (141), Expect = 3e-08
Identities = 45/149 (30%), Positives = 61/149 (40%), Gaps = 44/149 (29%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCT 257
C++ + C + P ND G C G C +G+MGK+CKE C C HG
Sbjct: 518 CEDGFTGPDCAELSCP-NDCHGQGRCVN-GQCVCHEGFMGKDCKEQRCPSDC---HG--- 569
Query: 258 VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPC 317
QGR CV G C+ C + GL C + + C S C
Sbjct: 570 -----------QGR----------CVDGQCI------CHEGFTGLDCGQ--HSCPS--DC 598
Query: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
N G C++ RC C +GYSG +C +
Sbjct: 599 NNLGQCVSG-----RCICNEGYSGEDCSE 622
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 225 bits (574), Expect = 2e-58
Identities = 205/685 (29%), Positives = 278/685 (40%), Gaps = 140/685 (20%)
Query: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCAN 358
+C ++ CG G CI+ P Y C C G+ G C + P
Sbjct: 481 MCQRNPQVCGP-------GRCIS-RPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCA 532
Query: 359 GGSCHEVPSGFECHCPSGW-SGPTCA--LDIDEC--ASNPCAAGGTCVDQVDGFECICPE 413
G C P F C C G+ +GP A LD+DEC PC G C + F C+CP
Sbjct: 533 PGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPA 591
Query: 414 QWV----GATCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 466
+ GA+CQ DV++C G C G CK+L ++CVCP GF G CE + DECA
Sbjct: 592 GYQAAPHGASCQ-DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACEEDVDECAQ 649
Query: 467 SPCHSG-GLCEDLADGFHCHCPQGFS----GPLCEVDVDLC--EPSPCRNGARCYNLEGD 519
P G G C++ A FHC CP GF G C+ DVD C P PC G RC N EG
Sbjct: 650 EPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGS 707
Query: 520 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 579
+ C CP F G C +D C + + P CV+ PG
Sbjct: 708 FQCVCPMGFQPNTA--------GSECEDVDECENH------------LACPGQECVNSPG 747
Query: 580 GNFSC-ICDSGFTGTYCHE----NIDDCLG--QPCRNGGTCIDEVDAFRCFC------PS 626
+F C C SG + H ++D+C PC G C + +FRC C PS
Sbjct: 748 -SFQCRTCPSGH---HLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 803
Query: 627 GWEGELCDTNPNDCLP-DPCHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAY 681
G G D N +CL D C G C + F C C G++ G +C + +C
Sbjct: 804 GRPGPCADVN--ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD-ECSEE 860
Query: 682 TCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP-------NPCVNGGT-CVGSGA 733
G C ++ +F C CPPG + A +SCL P + G C S
Sbjct: 861 DLCQSGICTNTDGSFECICPPGHR----AGPDLASCLDVDECRERGPALCGSQRCENSPG 916
Query: 734 SFSCI--CRDGWEGR---TCTHNTNDCN---PLPCYNGGICVDGVNWFRCE--CAPGFA- 782
S+ C+ C G+ TC + ++C P C C + +RC C PG+
Sbjct: 917 SYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCTPACDPGYQP 974
Query: 783 --GPDCRINIDECQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGT 839
G C+ ++DEC++ S C A C + ++C C G G R GR C
Sbjct: 975 TPGGGCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR------DGRHC----- 1022
Query: 840 PFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQ 899
D N C L G CG L + CP + G+
Sbjct: 1023 ---------VDVNECETLQG-------VCG--AALCENVEGSFLCVCPNSPEEFDPMTGR 1064
Query: 900 CLRPPCEAWGECGAE-EPPSTPCLP 923
C+ P A G++ + P++P LP
Sbjct: 1065 CVPPRTSAGTFPGSQPQAPASPVLP 1089
Score = 199 bits (505), Expect = 2e-50
Identities = 216/735 (29%), Positives = 282/735 (38%), Gaps = 145/735 (19%)
Query: 274 DECVPYPGCVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNG-GTCINAEPD 329
DEC C HG C + C C G L D + C S H + G C D
Sbjct: 292 DECATGGRCQHGECANTRGGYTCVCP---DGFLLDSSRSSCISQHVISEAKGPCFRVLRD 348
Query: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP----SGFECHCPSGWSGPTCALD 385
C+ P RN K C+ A G C P GF CP+G A D
Sbjct: 349 G-GCSLP---ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASD 404
Query: 386 ID---------------------ECASNPCAA----------GGTCVDQVDGFECICPE- 413
+ S P A D G E P
Sbjct: 405 LRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSI 464
Query: 414 -QWVGATCQLDVNDCRGQCQHG------GTCKDLVNGYQCVCPRGF----GGRHCELERD 462
W G + G CQ G C +GY C C GF G C ++ D
Sbjct: 465 PAWTGPEIP-ESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC-IDVD 522
Query: 463 EC--ASSPCHSGGLCEDLADGFHCHCPQGF-SGPLCE--VDVDLCE--PSPCRNGARCYN 515
EC PC + G CE+ F C C GF +GP +DVD C P PC G RC N
Sbjct: 523 ECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCEN 580
Query: 516 LEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTAASGVCGPHGRC 574
G + C CP + + P GA C+ +D C T + G+CG G C
Sbjct: 581 TPGSFLCVCPAGY---------QAAPHGASCQDVDEC----------TQSPGLCG-RGAC 620
Query: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNG-GTCIDEVDAFRCFCPSGWE---- 629
+ P G+F C+C +GF G+ C E++D+C +P G G C + +F C CP+G+
Sbjct: 621 KNLP-GSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 679
Query: 630 GELCDTNPNDCL--PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR---EFQCDAYTCS 684
G C + ++C P PC + GRC + F C C G++ T S +C+ +
Sbjct: 680 GAPCQ-DVDECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLAC 737
Query: 685 NGGTCYDSGDTFRC-ACPPG---WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICR 740
G C +S +F+C CP G +G V + SS P PC G C + SF C C
Sbjct: 738 PGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP-PCGPHGHCTNTEGSFRCSCA 796
Query: 741 DGW---EGR--TCTHNTNDCNPLP-CYNGGICVDGVNWFRCECAPGF----AGPDCRINI 790
G+ GR C + N+C C+ G C++ F C CAPG+ G C +++
Sbjct: 797 PGYRAPSGRPGPCA-DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDV 854
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPG-RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVE 849
DEC C + + C CPPG RAGP + C RG P GS E
Sbjct: 855 DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVD-ECRERG-PALCGSQRCE 912
Query: 850 DC-NSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAW 908
+ S RC+ RDC P AG PE C C E P C CE
Sbjct: 913 NSPGSYRCV---RDCD-------PGYHAG-PE---GTCDDVDECQEYGPEICGAQRCE-- 956
Query: 909 GECGAEEPPSTPCLP 923
P S C P
Sbjct: 957 -----NTPGSYRCTP 966
Score = 192 bits (488), Expect = 2e-48
Identities = 180/621 (28%), Positives = 247/621 (39%), Gaps = 114/621 (18%)
Query: 235 WMGKECKEAVCKQGCNLLHGGCTVPGEC---------RCSYGW----QGRFC---DEC-- 276
W G E E+ G + PG C C G+ QG C DEC
Sbjct: 467 WTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRR 526
Query: 277 VPYPGCVHGSCVEP---WQCNCETNW--GGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQ 330
VP P C G C ++C C + G + D++ C P + G C N P
Sbjct: 527 VP-PPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT-PGS 584
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANG-GSCHEVPSGFECHCPSGWSGPTCALD 385
+ C CP GY G +C+ + CT +P G G+C +P F C CP+G+ G C D
Sbjct: 585 FLCVCPAGYQAAPHGASCQDVDE-CTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 643
Query: 386 IDECASNPCAAG-GTCVDQVDGFECICP----EQWVGATCQLDVNDCRGQ---CQHGGTC 437
+DECA P G G C + F C CP + GA CQ DV++C C + G C
Sbjct: 644 VDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTY-GRC 701
Query: 438 KDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG--- 489
++ +QCVCP GF G CE + DEC + G C + F C CP G
Sbjct: 702 ENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGHHL 760
Query: 490 FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC-PGGACRVI 548
G +VD PC C N EG + C+C + R P G C +
Sbjct: 761 HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY--------RAPSGRPGPCADV 812
Query: 549 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLG 604
+ C C PHG C++ G+F+C C G+ G C + +D+C
Sbjct: 813 NEC-----------LEGDFCFPHGECLN-TDGSFACTCAPGYRPGPRGASCLD-VDECSE 859
Query: 605 QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP-DPCHSRG-------RCYDLVN 656
+ G C + +F C CP G + CL D C RG RC +
Sbjct: 860 EDLCQSGICTNTDGSFECICP---PGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 916
Query: 657 DFYCA--CDDGWKG---KTCHSREFQCDAYTCSNGGT--CYDSGDTFRC--ACPPGWK-- 705
+ C CD G+ TC + +C Y G C ++ ++RC AC PG++
Sbjct: 917 SYRCVRDCDPGYHAGPEGTCDDVD-ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT 975
Query: 706 -GSTCA---VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNP 757
G C +N S C C SF C+C G+E GR C + N+C
Sbjct: 976 PGGGCQDVDECRNRSF----CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCV-DVNECET 1030
Query: 758 LPCYNG-GICVDGVNWFRCEC 777
L G +C + F C C
Sbjct: 1031 LQGVCGAALCENVEGSFLCVC 1051
Score = 152 bits (384), Expect = 2e-36
Identities = 191/753 (25%), Positives = 269/753 (35%), Gaps = 181/753 (24%)
Query: 231 CMDGWMGKECKEAV---------CKQG-CNLLHGGCTVPGECRCSYGWQGRF-------C 273
C G+ G C+E V C G C+ G C C G++ R
Sbjct: 631 CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF----HCACPAGFRSRGPGAPCQDV 686
Query: 274 DECVPYPG-CVHGSCVEP---WQCNC----ETNWGGLLCDKDLNYCGSHHPCTNGGTCIN 325
DEC P C +G C +QC C + N G C+ D++ C +H C G C+N
Sbjct: 687 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACP-GQECVN 744
Query: 326 AEPDQYRC-TCPDGYS---GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPT 381
+ P ++C TCP G+ GR + E + + PC G C F C C G+ P+
Sbjct: 745 S-PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 803
Query: 382 -----CALDIDECASNP-CAAGGTCVDQVDGFECICPEQWV----GATCQLDVNDCRGQ- 430
CA D++EC C G C++ F C C + GA+C LDV++C +
Sbjct: 804 GRPGPCA-DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEED 861
Query: 431 -CQHGGTCKDLVNGYQCVCPRGFGG----RHCELERDECAS-SPCHSGGL-CEDLADGFH 483
CQ G C + ++C+CP G C L+ DEC P G CE+ +
Sbjct: 862 LCQ-SGICTNTDGSFECICPPGHRAGPDLASC-LDVDECRERGPALCGSQRCENSPGSYR 919
Query: 484 C--HCPQGF-SGP--LCEVDVDLCE---PSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 535
C C G+ +GP C+ DVD C+ P C RC N G Y C C
Sbjct: 920 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCT-------PACDP 970
Query: 536 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT---- 591
+P PGG C+ +D C + + CG H C + PG +F C+CD G+
Sbjct: 971 GYQPTPGGGCQDVDECRNRS-----------FCGAHAVCQNLPG-SFQCLCDQGYEGARD 1018
Query: 592 GTYCH-----------------ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
G +C EN++ C N D + RC P G
Sbjct: 1019 GRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG-RCVPPRTSAGTFPG 1077
Query: 635 TNPN---------------------------------DCL-----PDPCHSRGRCYDLVN 656
+ P +C PD C +
Sbjct: 1078 SQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQ 1137
Query: 657 DFYCACDDGWKG----KTCHSREFQCDAYTCSNG-GTCYDSGDTFRCACPPGWKGSTCAV 711
+ C +GW + C E C +G G SGD C +
Sbjct: 1138 ECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR-----DVDECQL 1192
Query: 712 AKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT----CTHNTNDCNPLPCYNGGICV 767
++ C G CV + +SC C +G+ T C N + P GG CV
Sbjct: 1193 FRDQVC------KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCV 1246
Query: 768 DGVNWFRCECAPGFA--GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
+ V + C C P G R +E QS G C E+ G C + PR
Sbjct: 1247 NTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLG-VCWQEV-GADLVC----SHPRLD 1300
Query: 826 EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 858
+ C +G +W DC C D
Sbjct: 1301 RQATYTECCCL------YGEAWGMDCALCPAQD 1327
Score = 122 bits (307), Expect = 2e-27
Identities = 147/583 (25%), Positives = 212/583 (36%), Gaps = 88/583 (15%)
Query: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
G + E + C + T C ++ H C + C++ +C+
Sbjct: 699 GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP---GQECVNSPGSFQCR--T 753
Query: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP---WQCNCETNW-- 299
C G +L G CT EC C P HG C ++C+C +
Sbjct: 754 CPSGHHLHRGRCTDVDECSSG-------APPCGP-----HGHCTNTEGSFRCSCAPGYRA 801
Query: 300 --GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTS 353
G D+N C C G C+N + + CTC GY G +C + C+
Sbjct: 802 PSGRPGPCADVNECLEGDFCFPHGECLNTD-GSFACTCAPGYRPGPRGASCLDVDE-CSE 859
Query: 354 NPCANGGSCHEVPSGFECHCPSGW-SGPTCA--LDIDECASNPCAAGGT--CVDQVDGFE 408
G C FEC CP G +GP A LD+DEC A G+ C + +
Sbjct: 860 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYR 919
Query: 409 CI--C-PEQWVG--ATCQLDVNDCRG---QCQHGGTCKDLVNGYQCV--CPRGFG---GR 455
C+ C P G TC DV++C+ + C++ Y+C C G+ G
Sbjct: 920 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 978
Query: 456 HCELERDECAS-SPCHSGGLCEDLADGFHCHCPQGFSGPL----CEVDVDLCEPSPCRNG 510
C+ + DEC + S C + +C++L F C C QG+ G C VDV+ CE G
Sbjct: 979 GCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCG 1036
Query: 511 AR-CYNLEGDYYCACP------DDFGGKNCSVPREPC---PGGACRVIDGCGSDAG---- 556
A C N+EG + C CP D G+ C PR PG + A
Sbjct: 1037 AALCENVEGSFLCVCPNSPEEFDPMTGR-CVPPRTSAGTFPGSQPQAPASPVLPARPPPP 1095
Query: 557 --PGMPGTAASGVCGPHGR-CVSQPGGNFSC--ICDSGFTGTYCHENIDDCLGQPCRNGG 611
P P T G G R C +C I T C + + G CR
Sbjct: 1096 PLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQ 1155
Query: 612 TCIDEVDAFRCFCPSGW-----EGELC---DTNPNDCLPDPCHSRGRCYDLVNDFYCACD 663
E ++ CP G G+L D + D G C + + C C
Sbjct: 1156 CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCS 1215
Query: 664 DGWKGKT----CHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
+G+ T C + D GG C ++ ++ C C P
Sbjct: 1216 NGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEP 1258
Score = 122 bits (306), Expect = 2e-27
Identities = 183/746 (24%), Positives = 263/746 (35%), Gaps = 168/746 (22%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEK------------------------AEHACT 352
C NGG C+ +PD RC CP ++G+ C+ A H
Sbjct: 90 CHNGGVCV--KPD--RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDD 145
Query: 353 SNPCANGGSCH-EVP--SGFECHCPSGWSGPTCALDIDECASNPCAAG------------ 397
+ A+ S H E P + H SGP D + A AA
Sbjct: 146 EHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQ 205
Query: 398 --------------GTCVDQVDGFECICPEQWV--------GATCQLDVNDCRGQCQHGG 435
G C ++ G EC P + GA V+DC+ + G
Sbjct: 206 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 265
Query: 436 TCKDLVNGYQCVCPRGFG--GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493
+ V+ CP GF CE + DECA+ G C + G+ C CP GF
Sbjct: 266 N-SERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGF--- 320
Query: 494 LCEVDVDLCEPSPCRNGAR--CYNLEGDYYCACP--DDFGGKNCSVPRE-PCPGGACRVI 548
L + C + A+ C+ + D C+ P + + C R G C++
Sbjct: 321 LLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLC 380
Query: 549 DGCGSD-------AGPGMPGTAASGVCG-------PHGRCVSQPGGNFSCICDS-GFTGT 593
GS+ AGPG +A+ P +SQP + S GF T
Sbjct: 381 PPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPT 440
Query: 594 YCHENIDDCLGQPCRNGGTCIDEVDAFRC--FCPSGWEGELCDTNPNDCLPDPCHSRGRC 651
+ E + P + + A+ SG +C NP C P GRC
Sbjct: 441 HRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGP------GRC 494
Query: 652 YDLVNDFYCACDDGWKGKTCHSREFQCDAYT-----CSNGGTCYDSGDTFRCACPPGWKG 706
+ + CACD G++ +R D C+ G C +S +FRC C PG++
Sbjct: 495 ISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRA 553
Query: 707 ----STCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNPL 758
+ C +P PC + G C + SF C+C G++ G +C + ++C
Sbjct: 554 GPRAAECLDVDECHRVPPPC-DLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDECTQS 611
Query: 759 PCYNG-GICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYG-ATCVDEINGYRCSCP 816
P G G C + FRC C GF G C ++DEC P G C + + C+CP
Sbjct: 612 PGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACP 671
Query: 817 PG----RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP 872
G G CQ+V C P +G C +G C
Sbjct: 672 AGFRSRGPGAPCQDV----DECARSPPPCTYG--------RCENTEGSFQC--------V 711
Query: 873 CLLAGQPEALSAQCP-----------LGQRCLEKAPG--QCLRPP---------CEAWGE 910
C + QP ++C GQ C+ +PG QC P C E
Sbjct: 712 CPMGFQPNTAGSECEDVDECENHLACPGQECV-NSPGSFQCRTCPSGHHLHRGRCTDVDE 770
Query: 911 CGAEEPPSTP---CLPRSGHLDNNCA 933
C + PP P C G +CA
Sbjct: 771 CSSGAPPCGPHGHCTNTEGSFRCSCA 796
Score = 68.2 bits (165), Expect = 5e-11
Identities = 165/712 (23%), Positives = 228/712 (32%), Gaps = 224/712 (31%)
Query: 355 PCANGGSCHEVPSGFECHCPSGWSGPTCA----LDIDECASNPCAAGGTCVDQVDGFECI 410
P G C P+G C PTCA +D A A GG GF
Sbjct: 38 PVVCGLRCVHGPTGSRCT-------PTCAPRNATSVDSGAPGGAAPGGP------GFRAF 84
Query: 411 CPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCH 470
C C +GG C V +C+CP F G+ C+L
Sbjct: 85 L---------------CPLICHNGGVC---VKPDRCLCPPDFAGKFCQLHSSGARPPAPA 126
Query: 471 SGGLCEDL--------ADGFH-------------------CHCPQGFSGPLCEVDVDL-- 501
GL + D H H + SGP E D +
Sbjct: 127 VPGLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVA 186
Query: 502 -CEPSPCRNGARCYNL-------EGDYYCA-----CPDDFGGKNCSVPREPCPGGACRVI 548
E + A Y + E Y A C + G C+ P PG R
Sbjct: 187 RAEAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECA---SPLPG--LRTQ 241
Query: 549 DGCGSDAGPGMPGTAASGVCGP---HGRCVSQPGGNFSCICDSGF--TGTYCHENIDDC- 602
+ C AG G +C + VS P G C +GF C E++D+C
Sbjct: 242 EVCCRGAGLAW-GVHDCQLCSERLGNSERVSAPDGP----CPTGFERVNGSC-EDVDECA 295
Query: 603 LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDP--CHSRGRCYDLVNDFYC 660
G C++ G C + + C CP G+ L D++ + C+ ++G C+ ++ D C
Sbjct: 296 TGGRCQH-GECANTRGGYTCVCPDGF---LLDSSRSSCISQHVISEAKGPCFRVLRDGGC 351
Query: 661 ACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG---------DTFRCACP--PGWKGSTC 709
+ R CS G + G + FR CP PG+ S
Sbjct: 352 SLP--------ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSAS 403
Query: 710 AVAKNSSCL--------------------------------------PNPCVNGGTCVGS 731
+ N+ L P+P + S
Sbjct: 404 DLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPS 463
Query: 732 GASFSC--ICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF----AGPD 785
+++ I G C N C P G C+ + + C C GF G
Sbjct: 464 IPAWTGPEIPESGPSSGMCQRNPQVCGP------GRCISRPSGYTCACDSGFRLSPQGTR 517
Query: 786 CRINIDECQ--SSPCAYGATCVDEINGYRCSCPPG-RAGPRCQEVI------------GF 830
C I++DEC+ PCA G C + +RC C PG RAGPR E +
Sbjct: 518 C-IDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDL 575
Query: 831 GRS----------CWSRGTPFPHGSSW--VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQ 878
GR C + PHG+S V++C L GR C +
Sbjct: 576 GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNL------------ 623
Query: 879 PEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDN 930
P + CP G R CE + A+EPP PC P G DN
Sbjct: 624 PGSFRCVCPAGFR----------GSACEEDVDECAQEPP--PCGP--GRCDN 661
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 458 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCE----PSPCRNG 510
ELE +EC + G C + +GF C C G+ + VD++ C+ SP
Sbjct: 1464 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523
Query: 511 ARCYNLEGDYYCACPDDF 528
ARC N +G + C C F
Sbjct: 1524 ARCLNTDGSFRCICRPGF 1541
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 336 PDG--YSGRNCE-----KAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALD 385
P+G Y+G E +AE + C NG C VP GF C C G+ +D
Sbjct: 1449 PEGGSYAGSLAEPYEELEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVD 1507
Query: 386 IDEC----ASNPCAAGGTCVDQVDGFECIC 411
I+EC A++P C++ F CIC
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCIC 1537
Score = 38.9 bits (89), Expect = 0.030
Identities = 31/99 (31%), Positives = 38/99 (38%), Gaps = 13/99 (13%)
Query: 693 GDTFRCACPPGWKGSTCAVAKNSS-CLPNPCVNGGTCVGSGASFSCICRD-GWEGRTCTH 750
G+ R P G C S C P T V SGA G+ C
Sbjct: 29 GERLRVRFTPVVCGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLC-- 86
Query: 751 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 789
PL C+NGG+CV RC C P FAG C+++
Sbjct: 87 ------PLICHNGGVCVKP---DRCLCPPDFAGKFCQLH 116
Score = 38.1 bits (87), Expect = 0.051
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 754 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCR---INIDECQ----SSPCAYGATCVD 806
+C L G CV F C C G+ R ++I+EC +SP A C++
Sbjct: 1469 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLN 1528
Query: 807 EINGYRCSCPPGRA 820
+RC C PG A
Sbjct: 1529 TDGSFRCICRPGFA 1542
Score = 35.4 bits (80), Expect = 0.33
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 18/85 (21%)
Query: 683 CSNGGTCYDSGDTFRCACPPGWKG----------STCAVAKNSSCLPNPCVNGGTCVGSG 732
C+NG C + F C C G++ + C A+ +S L CVN C+ +
Sbjct: 1476 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL---CVNA-RCLNTD 1530
Query: 733 ASFSCICRDGWEGRTCTHNTNDCNP 757
SF CICR G+ TH + C P
Sbjct: 1531 GSFRCICRPGF---APTHQPHHCAP 1552
Score = 35.0 bits (79), Expect = 0.43
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 31/115 (26%)
Query: 536 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----T 591
P E C ++DGC +GRCV P G F+C C G+ T
Sbjct: 1461 PYEELEAEECGILDGC------------------TNGRCVRVPEG-FTCRCFDGYRLDMT 1501
Query: 592 GTYCHENIDDC----LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642
C + I++C P C++ +FRC C G+ P+ C P
Sbjct: 1502 RMACVD-INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP---THQPHHCAP 1552
Score = 32.7 bits (73), Expect = 2.1
Identities = 19/81 (23%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQW---VGATCQLDVNDC-----RGQCQHGG 435
L+ +EC G CV +GF C C + + + +D+N+C
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524
Query: 436 TCKDLVNGYQCVCPRGFGGRH 456
C + ++C+C GF H
Sbjct: 1525 RCLNTDGSFRCICRPGFAPTH 1545
Score = 32.7 bits (73), Expect = 2.1
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 18/88 (20%)
Query: 507 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 566
C NG RC + + C C F G + R AC I+ C AAS
Sbjct: 1476 CTNG-RCVRVPEGFTCRC---FDGYRLDMTRM-----ACVDINECDE-------AEAASP 1519
Query: 567 VCGPHGRCVSQPGGNFSCICDSGFTGTY 594
+C + RC++ G +F CIC GF T+
Sbjct: 1520 LC-VNARCLNTDG-SFRCICRPGFAPTH 1545
Score = 31.2 bits (69), Expect = 6.2
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 14/94 (14%)
Query: 274 DECVPYPGCVHGSCV---EPWQCNC----ETNWGGLLCDKDLNYCG---SHHPCTNGGTC 323
+EC GC +G CV E + C C + + C D+N C + P C
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARC 1526
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+N + +RC C G++ + + H + P A
Sbjct: 1527 LNTD-GSFRCICRPGFAPTH--QPHHCAPARPRA 1557
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 225 bits (574), Expect = 2e-58
Identities = 205/685 (29%), Positives = 278/685 (40%), Gaps = 140/685 (20%)
Query: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCAN 358
+C ++ CG G CI+ P Y C C G+ G C + P
Sbjct: 511 MCQRNPQVCGP-------GRCIS-RPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCA 562
Query: 359 GGSCHEVPSGFECHCPSGW-SGPTCA--LDIDEC--ASNPCAAGGTCVDQVDGFECICPE 413
G C P F C C G+ +GP A LD+DEC PC G C + F C+CP
Sbjct: 563 PGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPA 621
Query: 414 QWV----GATCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 466
+ GA+CQ DV++C G C G CK+L ++CVCP GF G CE + DECA
Sbjct: 622 GYQAAPHGASCQ-DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACEEDVDECAQ 679
Query: 467 SPCHSG-GLCEDLADGFHCHCPQGFS----GPLCEVDVDLC--EPSPCRNGARCYNLEGD 519
P G G C++ A FHC CP GF G C+ DVD C P PC G RC N EG
Sbjct: 680 EPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGS 737
Query: 520 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 579
+ C CP F G C +D C + + P CV+ PG
Sbjct: 738 FQCVCPMGFQPNTA--------GSECEDVDECENH------------LACPGQECVNSPG 777
Query: 580 GNFSC-ICDSGFTGTYCHE----NIDDCLG--QPCRNGGTCIDEVDAFRCFC------PS 626
+F C C SG + H ++D+C PC G C + +FRC C PS
Sbjct: 778 -SFQCRTCPSGH---HLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 833
Query: 627 GWEGELCDTNPNDCLP-DPCHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAY 681
G G D N +CL D C G C + F C C G++ G +C + +C
Sbjct: 834 GRPGPCADVN--ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD-ECSEE 890
Query: 682 TCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP-------NPCVNGGT-CVGSGA 733
G C ++ +F C CPPG + A +SCL P + G C S
Sbjct: 891 DLCQSGICTNTDGSFECICPPGHR----AGPDLASCLDVDECRERGPALCGSQRCENSPG 946
Query: 734 SFSCI--CRDGWEGR---TCTHNTNDCN---PLPCYNGGICVDGVNWFRCE--CAPGFA- 782
S+ C+ C G+ TC + ++C P C C + +RC C PG+
Sbjct: 947 SYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCTPACDPGYQP 1004
Query: 783 --GPDCRINIDECQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGT 839
G C+ ++DEC++ S C A C + ++C C G G R GR C
Sbjct: 1005 TPGGGCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR------DGRHC----- 1052
Query: 840 PFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQ 899
D N C L G CG L + CP + G+
Sbjct: 1053 ---------VDVNECETLQG-------VCG--AALCENVEGSFLCVCPNSPEEFDPMTGR 1094
Query: 900 CLRPPCEAWGECGAE-EPPSTPCLP 923
C+ P A G++ + P++P LP
Sbjct: 1095 CVPPRTSAGTFPGSQPQAPASPVLP 1119
Score = 199 bits (505), Expect = 2e-50
Identities = 216/735 (29%), Positives = 282/735 (38%), Gaps = 145/735 (19%)
Query: 274 DECVPYPGCVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNG-GTCINAEPD 329
DEC C HG C + C C G L D + C S H + G C D
Sbjct: 322 DECATGGRCQHGECANTRGGYTCVCP---DGFLLDSSRSSCISQHVISEAKGPCFRVLRD 378
Query: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP----SGFECHCPSGWSGPTCALD 385
C+ P RN K C+ A G C P GF CP+G A D
Sbjct: 379 G-GCSLP---ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASD 434
Query: 386 ID---------------------ECASNPCAA----------GGTCVDQVDGFECICPE- 413
+ S P A D G E P
Sbjct: 435 LRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSI 494
Query: 414 -QWVGATCQLDVNDCRGQCQHG------GTCKDLVNGYQCVCPRGF----GGRHCELERD 462
W G + G CQ G C +GY C C GF G C ++ D
Sbjct: 495 PAWTGPEIP-ESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC-IDVD 552
Query: 463 EC--ASSPCHSGGLCEDLADGFHCHCPQGF-SGPLCE--VDVDLCE--PSPCRNGARCYN 515
EC PC + G CE+ F C C GF +GP +DVD C P PC G RC N
Sbjct: 553 ECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCEN 610
Query: 516 LEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTAASGVCGPHGRC 574
G + C CP + + P GA C+ +D C T + G+CG G C
Sbjct: 611 TPGSFLCVCPAGY---------QAAPHGASCQDVDEC----------TQSPGLCG-RGAC 650
Query: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNG-GTCIDEVDAFRCFCPSGWE---- 629
+ P G+F C+C +GF G+ C E++D+C +P G G C + +F C CP+G+
Sbjct: 651 KNLP-GSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 709
Query: 630 GELCDTNPNDCL--PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR---EFQCDAYTCS 684
G C + ++C P PC + GRC + F C C G++ T S +C+ +
Sbjct: 710 GAPCQ-DVDECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLAC 767
Query: 685 NGGTCYDSGDTFRC-ACPPG---WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICR 740
G C +S +F+C CP G +G V + SS P PC G C + SF C C
Sbjct: 768 PGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP-PCGPHGHCTNTEGSFRCSCA 826
Query: 741 DGW---EGR--TCTHNTNDCNPLP-CYNGGICVDGVNWFRCECAPGF----AGPDCRINI 790
G+ GR C + N+C C+ G C++ F C CAPG+ G C +++
Sbjct: 827 PGYRAPSGRPGPCA-DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDV 884
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPG-RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVE 849
DEC C + + C CPPG RAGP + C RG P GS E
Sbjct: 885 DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVD-ECRERG-PALCGSQRCE 942
Query: 850 DC-NSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAW 908
+ S RC+ RDC P AG PE C C E P C CE
Sbjct: 943 NSPGSYRCV---RDCD-------PGYHAG-PE---GTCDDVDECQEYGPEICGAQRCE-- 986
Query: 909 GECGAEEPPSTPCLP 923
P S C P
Sbjct: 987 -----NTPGSYRCTP 996
Score = 192 bits (488), Expect = 2e-48
Identities = 180/621 (28%), Positives = 247/621 (39%), Gaps = 114/621 (18%)
Query: 235 WMGKECKEAVCKQGCNLLHGGCTVPGEC---------RCSYGW----QGRFC---DEC-- 276
W G E E+ G + PG C C G+ QG C DEC
Sbjct: 497 WTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRR 556
Query: 277 VPYPGCVHGSCVEP---WQCNCETNW--GGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQ 330
VP P C G C ++C C + G + D++ C P + G C N P
Sbjct: 557 VP-PPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT-PGS 614
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANG-GSCHEVPSGFECHCPSGWSGPTCALD 385
+ C CP GY G +C+ + CT +P G G+C +P F C CP+G+ G C D
Sbjct: 615 FLCVCPAGYQAAPHGASCQDVDE-CTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 673
Query: 386 IDECASNPCAAG-GTCVDQVDGFECICP----EQWVGATCQLDVNDCRGQ---CQHGGTC 437
+DECA P G G C + F C CP + GA CQ DV++C C + G C
Sbjct: 674 VDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTY-GRC 731
Query: 438 KDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG--- 489
++ +QCVCP GF G CE + DEC + G C + F C CP G
Sbjct: 732 ENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGHHL 790
Query: 490 FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC-PGGACRVI 548
G +VD PC C N EG + C+C + R P G C +
Sbjct: 791 HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY--------RAPSGRPGPCADV 842
Query: 549 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLG 604
+ C C PHG C++ G+F+C C G+ G C + +D+C
Sbjct: 843 NEC-----------LEGDFCFPHGECLN-TDGSFACTCAPGYRPGPRGASCLD-VDECSE 889
Query: 605 QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP-DPCHSRG-------RCYDLVN 656
+ G C + +F C CP G + CL D C RG RC +
Sbjct: 890 EDLCQSGICTNTDGSFECICP---PGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 946
Query: 657 DFYCA--CDDGWKG---KTCHSREFQCDAYTCSNGGT--CYDSGDTFRC--ACPPGWK-- 705
+ C CD G+ TC + +C Y G C ++ ++RC AC PG++
Sbjct: 947 SYRCVRDCDPGYHAGPEGTCDDVD-ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT 1005
Query: 706 -GSTCA---VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNP 757
G C +N S C C SF C+C G+E GR C + N+C
Sbjct: 1006 PGGGCQDVDECRNRSF----CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCV-DVNECET 1060
Query: 758 LPCYNG-GICVDGVNWFRCEC 777
L G +C + F C C
Sbjct: 1061 LQGVCGAALCENVEGSFLCVC 1081
Score = 152 bits (384), Expect = 2e-36
Identities = 191/753 (25%), Positives = 269/753 (35%), Gaps = 181/753 (24%)
Query: 231 CMDGWMGKECKEAV---------CKQG-CNLLHGGCTVPGECRCSYGWQGRF-------C 273
C G+ G C+E V C G C+ G C C G++ R
Sbjct: 661 CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF----HCACPAGFRSRGPGAPCQDV 716
Query: 274 DECVPYPG-CVHGSCVEP---WQCNC----ETNWGGLLCDKDLNYCGSHHPCTNGGTCIN 325
DEC P C +G C +QC C + N G C+ D++ C +H C G C+N
Sbjct: 717 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACP-GQECVN 774
Query: 326 AEPDQYRC-TCPDGYS---GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPT 381
+ P ++C TCP G+ GR + E + + PC G C F C C G+ P+
Sbjct: 775 S-PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 833
Query: 382 -----CALDIDECASNP-CAAGGTCVDQVDGFECICPEQWV----GATCQLDVNDCRGQ- 430
CA D++EC C G C++ F C C + GA+C LDV++C +
Sbjct: 834 GRPGPCA-DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEED 891
Query: 431 -CQHGGTCKDLVNGYQCVCPRGFGG----RHCELERDECAS-SPCHSGGL-CEDLADGFH 483
CQ G C + ++C+CP G C L+ DEC P G CE+ +
Sbjct: 892 LCQ-SGICTNTDGSFECICPPGHRAGPDLASC-LDVDECRERGPALCGSQRCENSPGSYR 949
Query: 484 C--HCPQGF-SGP--LCEVDVDLCE---PSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 535
C C G+ +GP C+ DVD C+ P C RC N G Y C C
Sbjct: 950 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCT-------PACDP 1000
Query: 536 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT---- 591
+P PGG C+ +D C + + CG H C + PG +F C+CD G+
Sbjct: 1001 GYQPTPGGGCQDVDECRNRS-----------FCGAHAVCQNLPG-SFQCLCDQGYEGARD 1048
Query: 592 GTYCH-----------------ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
G +C EN++ C N D + RC P G
Sbjct: 1049 GRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG-RCVPPRTSAGTFPG 1107
Query: 635 TNPN---------------------------------DCL-----PDPCHSRGRCYDLVN 656
+ P +C PD C +
Sbjct: 1108 SQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQ 1167
Query: 657 DFYCACDDGWKG----KTCHSREFQCDAYTCSNG-GTCYDSGDTFRCACPPGWKGSTCAV 711
+ C +GW + C E C +G G SGD C +
Sbjct: 1168 ECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR-----DVDECQL 1222
Query: 712 AKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT----CTHNTNDCNPLPCYNGGICV 767
++ C G CV + +SC C +G+ T C N + P GG CV
Sbjct: 1223 FRDQVC------KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCV 1276
Query: 768 DGVNWFRCECAPGFA--GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
+ V + C C P G R +E QS G C E+ G C + PR
Sbjct: 1277 NTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLG-VCWQEV-GADLVC----SHPRLD 1330
Query: 826 EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 858
+ C +G +W DC C D
Sbjct: 1331 RQATYTECCCL------YGEAWGMDCALCPAQD 1357
Score = 122 bits (307), Expect = 2e-27
Identities = 147/583 (25%), Positives = 212/583 (36%), Gaps = 88/583 (15%)
Query: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
G + E + C + T C ++ H C + C++ +C+
Sbjct: 729 GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP---GQECVNSPGSFQCR--T 783
Query: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP---WQCNCETNW-- 299
C G +L G CT EC C P HG C ++C+C +
Sbjct: 784 CPSGHHLHRGRCTDVDECSSG-------APPCGP-----HGHCTNTEGSFRCSCAPGYRA 831
Query: 300 --GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTS 353
G D+N C C G C+N + + CTC GY G +C + C+
Sbjct: 832 PSGRPGPCADVNECLEGDFCFPHGECLNTD-GSFACTCAPGYRPGPRGASCLDVDE-CSE 889
Query: 354 NPCANGGSCHEVPSGFECHCPSGW-SGPTCA--LDIDECASNPCAAGGT--CVDQVDGFE 408
G C FEC CP G +GP A LD+DEC A G+ C + +
Sbjct: 890 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYR 949
Query: 409 CI--C-PEQWVG--ATCQLDVNDCRG---QCQHGGTCKDLVNGYQCV--CPRGFG---GR 455
C+ C P G TC DV++C+ + C++ Y+C C G+ G
Sbjct: 950 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 1008
Query: 456 HCELERDECAS-SPCHSGGLCEDLADGFHCHCPQGFSGPL----CEVDVDLCEPSPCRNG 510
C+ + DEC + S C + +C++L F C C QG+ G C VDV+ CE G
Sbjct: 1009 GCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCG 1066
Query: 511 AR-CYNLEGDYYCACP------DDFGGKNCSVPREPC---PGGACRVIDGCGSDAG---- 556
A C N+EG + C CP D G+ C PR PG + A
Sbjct: 1067 AALCENVEGSFLCVCPNSPEEFDPMTGR-CVPPRTSAGTFPGSQPQAPASPVLPARPPPP 1125
Query: 557 --PGMPGTAASGVCGPHGR-CVSQPGGNFSC--ICDSGFTGTYCHENIDDCLGQPCRNGG 611
P P T G G R C +C I T C + + G CR
Sbjct: 1126 PLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQ 1185
Query: 612 TCIDEVDAFRCFCPSGW-----EGELC---DTNPNDCLPDPCHSRGRCYDLVNDFYCACD 663
E ++ CP G G+L D + D G C + + C C
Sbjct: 1186 CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCS 1245
Query: 664 DGWKGKT----CHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
+G+ T C + D GG C ++ ++ C C P
Sbjct: 1246 NGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEP 1288
Score = 122 bits (306), Expect = 2e-27
Identities = 183/746 (24%), Positives = 263/746 (35%), Gaps = 168/746 (22%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEK------------------------AEHACT 352
C NGG C+ +PD RC CP ++G+ C+ A H
Sbjct: 120 CHNGGVCV--KPD--RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDD 175
Query: 353 SNPCANGGSCH-EVP--SGFECHCPSGWSGPTCALDIDECASNPCAAG------------ 397
+ A+ S H E P + H SGP D + A AA
Sbjct: 176 EHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQ 235
Query: 398 --------------GTCVDQVDGFECICPEQWV--------GATCQLDVNDCRGQCQHGG 435
G C ++ G EC P + GA V+DC+ + G
Sbjct: 236 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 295
Query: 436 TCKDLVNGYQCVCPRGFG--GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493
+ V+ CP GF CE + DECA+ G C + G+ C CP GF
Sbjct: 296 N-SERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGF--- 350
Query: 494 LCEVDVDLCEPSPCRNGAR--CYNLEGDYYCACP--DDFGGKNCSVPRE-PCPGGACRVI 548
L + C + A+ C+ + D C+ P + + C R G C++
Sbjct: 351 LLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLC 410
Query: 549 DGCGSD-------AGPGMPGTAASGVCG-------PHGRCVSQPGGNFSCICDS-GFTGT 593
GS+ AGPG +A+ P +SQP + S GF T
Sbjct: 411 PPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPT 470
Query: 594 YCHENIDDCLGQPCRNGGTCIDEVDAFRC--FCPSGWEGELCDTNPNDCLPDPCHSRGRC 651
+ E + P + + A+ SG +C NP C P GRC
Sbjct: 471 HRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGP------GRC 524
Query: 652 YDLVNDFYCACDDGWKGKTCHSREFQCDAYT-----CSNGGTCYDSGDTFRCACPPGWKG 706
+ + CACD G++ +R D C+ G C +S +FRC C PG++
Sbjct: 525 ISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRA 583
Query: 707 ----STCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNPL 758
+ C +P PC + G C + SF C+C G++ G +C + ++C
Sbjct: 584 GPRAAECLDVDECHRVPPPC-DLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDECTQS 641
Query: 759 PCYNG-GICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYG-ATCVDEINGYRCSCP 816
P G G C + FRC C GF G C ++DEC P G C + + C+CP
Sbjct: 642 PGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACP 701
Query: 817 PG----RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP 872
G G CQ+V C P +G C +G C
Sbjct: 702 AGFRSRGPGAPCQDV----DECARSPPPCTYG--------RCENTEGSFQC--------V 741
Query: 873 CLLAGQPEALSAQCP-----------LGQRCLEKAPG--QCLRPP---------CEAWGE 910
C + QP ++C GQ C+ +PG QC P C E
Sbjct: 742 CPMGFQPNTAGSECEDVDECENHLACPGQECV-NSPGSFQCRTCPSGHHLHRGRCTDVDE 800
Query: 911 CGAEEPPSTP---CLPRSGHLDNNCA 933
C + PP P C G +CA
Sbjct: 801 CSSGAPPCGPHGHCTNTEGSFRCSCA 826
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 458 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCE----PSPCRNG 510
ELE +EC + G C + +GF C C G+ + VD++ C+ SP
Sbjct: 1494 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553
Query: 511 ARCYNLEGDYYCACPDDF 528
ARC N +G + C C F
Sbjct: 1554 ARCLNTDGSFRCICRPGF 1571
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 336 PDG--YSGRNCE-----KAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALD 385
P+G Y+G E +AE + C NG C VP GF C C G+ +D
Sbjct: 1479 PEGGSYAGSLAEPYEELEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVD 1537
Query: 386 IDEC----ASNPCAAGGTCVDQVDGFECIC 411
I+EC A++P C++ F CIC
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCIC 1567
Score = 38.1 bits (87), Expect = 0.051
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 754 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCR---INIDECQ----SSPCAYGATCVD 806
+C L G CV F C C G+ R ++I+EC +SP A C++
Sbjct: 1499 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLN 1558
Query: 807 EINGYRCSCPPGRA 820
+RC C PG A
Sbjct: 1559 TDGSFRCICRPGFA 1572
Score = 36.6 bits (83), Expect = 0.15
Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 3/33 (9%)
Query: 757 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 789
PL C+NGG+CV RC C P FAG C+++
Sbjct: 117 PLICHNGGVCVKP---DRCLCPPDFAGKFCQLH 146
Score = 35.4 bits (80), Expect = 0.33
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 18/85 (21%)
Query: 683 CSNGGTCYDSGDTFRCACPPGWKG----------STCAVAKNSSCLPNPCVNGGTCVGSG 732
C+NG C + F C C G++ + C A+ +S L CVN C+ +
Sbjct: 1506 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL---CVNA-RCLNTD 1560
Query: 733 ASFSCICRDGWEGRTCTHNTNDCNP 757
SF CICR G+ TH + C P
Sbjct: 1561 GSFRCICRPGF---APTHQPHHCAP 1582
Score = 35.0 bits (79), Expect = 0.43
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 31/115 (26%)
Query: 536 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----T 591
P E C ++DGC +GRCV P G F+C C G+ T
Sbjct: 1491 PYEELEAEECGILDGC------------------TNGRCVRVPEG-FTCRCFDGYRLDMT 1531
Query: 592 GTYCHENIDDC----LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642
C + I++C P C++ +FRC C G+ P+ C P
Sbjct: 1532 RMACVD-INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP---THQPHHCAP 1582
Score = 32.7 bits (73), Expect = 2.1
Identities = 19/81 (23%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQW---VGATCQLDVNDC-----RGQCQHGG 435
L+ +EC G CV +GF C C + + + +D+N+C
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554
Query: 436 TCKDLVNGYQCVCPRGFGGRH 456
C + ++C+C GF H
Sbjct: 1555 RCLNTDGSFRCICRPGFAPTH 1575
Score = 32.7 bits (73), Expect = 2.1
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 18/88 (20%)
Query: 507 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 566
C NG RC + + C C F G + R AC I+ C AAS
Sbjct: 1506 CTNG-RCVRVPEGFTCRC---FDGYRLDMTRM-----ACVDINECDE-------AEAASP 1549
Query: 567 VCGPHGRCVSQPGGNFSCICDSGFTGTY 594
+C + RC++ G +F CIC GF T+
Sbjct: 1550 LC-VNARCLNTDG-SFRCICRPGFAPTH 1575
Score = 31.2 bits (69), Expect = 6.2
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 14/94 (14%)
Query: 274 DECVPYPGCVHGSCV---EPWQCNC----ETNWGGLLCDKDLNYCG---SHHPCTNGGTC 323
+EC GC +G CV E + C C + + C D+N C + P C
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARC 1556
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+N + +RC C G++ + + H + P A
Sbjct: 1557 LNTD-GSFRCICRPGFAPTH--QPHHCAPARPRA 1587
Score = 30.8 bits (68), Expect = 8.1
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 13/59 (22%)
Query: 449 PRGFGGRHC----ELERDECASSP------CHSGGLCEDLADGFHCHCPQGFSGPLCEV 497
PRG GGR +R +P CH+GG+C C CP F+G C++
Sbjct: 90 PRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVC---VKPDRCLCPPDFAGKFCQL 145
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 225 bits (574), Expect = 2e-58
Identities = 205/685 (29%), Positives = 278/685 (40%), Gaps = 140/685 (20%)
Query: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNPCAN 358
+C ++ CG G CI+ P Y C C G+ G C + P
Sbjct: 548 MCQRNPQVCGP-------GRCIS-RPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCA 599
Query: 359 GGSCHEVPSGFECHCPSGW-SGPTCA--LDIDEC--ASNPCAAGGTCVDQVDGFECICPE 413
G C P F C C G+ +GP A LD+DEC PC G C + F C+CP
Sbjct: 600 PGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCENTPGSFLCVCPA 658
Query: 414 QWV----GATCQLDVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 466
+ GA+CQ DV++C G C G CK+L ++CVCP GF G CE + DECA
Sbjct: 659 GYQAAPHGASCQ-DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACEEDVDECAQ 716
Query: 467 SPCHSG-GLCEDLADGFHCHCPQGFS----GPLCEVDVDLC--EPSPCRNGARCYNLEGD 519
P G G C++ A FHC CP GF G C+ DVD C P PC G RC N EG
Sbjct: 717 EPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGS 774
Query: 520 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 579
+ C CP F G C +D C + + P CV+ PG
Sbjct: 775 FQCVCPMGFQPNTA--------GSECEDVDECENH------------LACPGQECVNSPG 814
Query: 580 GNFSC-ICDSGFTGTYCHE----NIDDCLG--QPCRNGGTCIDEVDAFRCFC------PS 626
+F C C SG + H ++D+C PC G C + +FRC C PS
Sbjct: 815 -SFQCRTCPSGH---HLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 870
Query: 627 GWEGELCDTNPNDCLP-DPCHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAY 681
G G D N +CL D C G C + F C C G++ G +C + +C
Sbjct: 871 GRPGPCADVN--ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD-ECSEE 927
Query: 682 TCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP-------NPCVNGGT-CVGSGA 733
G C ++ +F C CPPG + A +SCL P + G C S
Sbjct: 928 DLCQSGICTNTDGSFECICPPGHR----AGPDLASCLDVDECRERGPALCGSQRCENSPG 983
Query: 734 SFSCI--CRDGWEGR---TCTHNTNDCN---PLPCYNGGICVDGVNWFRCE--CAPGFA- 782
S+ C+ C G+ TC + ++C P C C + +RC C PG+
Sbjct: 984 SYRCVRDCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCTPACDPGYQP 1041
Query: 783 --GPDCRINIDECQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGT 839
G C+ ++DEC++ S C A C + ++C C G G R GR C
Sbjct: 1042 TPGGGCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR------DGRHC----- 1089
Query: 840 PFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQ 899
D N C L G CG L + CP + G+
Sbjct: 1090 ---------VDVNECETLQG-------VCG--AALCENVEGSFLCVCPNSPEEFDPMTGR 1131
Query: 900 CLRPPCEAWGECGAE-EPPSTPCLP 923
C+ P A G++ + P++P LP
Sbjct: 1132 CVPPRTSAGTFPGSQPQAPASPVLP 1156
Score = 199 bits (505), Expect = 2e-50
Identities = 216/735 (29%), Positives = 282/735 (38%), Gaps = 145/735 (19%)
Query: 274 DECVPYPGCVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNG-GTCINAEPD 329
DEC C HG C + C C G L D + C S H + G C D
Sbjct: 359 DECATGGRCQHGECANTRGGYTCVCP---DGFLLDSSRSSCISQHVISEAKGPCFRVLRD 415
Query: 330 QYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP----SGFECHCPSGWSGPTCALD 385
C+ P RN K C+ A G C P GF CP+G A D
Sbjct: 416 G-GCSLP---ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASD 471
Query: 386 ID---------------------ECASNPCAA----------GGTCVDQVDGFECICPE- 413
+ S P A D G E P
Sbjct: 472 LRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSI 531
Query: 414 -QWVGATCQLDVNDCRGQCQHG------GTCKDLVNGYQCVCPRGF----GGRHCELERD 462
W G + G CQ G C +GY C C GF G C ++ D
Sbjct: 532 PAWTGPEIP-ESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC-IDVD 589
Query: 463 EC--ASSPCHSGGLCEDLADGFHCHCPQGF-SGPLCE--VDVDLCE--PSPCRNGARCYN 515
EC PC + G CE+ F C C GF +GP +DVD C P PC G RC N
Sbjct: 590 ECRRVPPPC-APGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLG-RCEN 647
Query: 516 LEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTAASGVCGPHGRC 574
G + C CP + + P GA C+ +D C T + G+CG G C
Sbjct: 648 TPGSFLCVCPAGY---------QAAPHGASCQDVDEC----------TQSPGLCG-RGAC 687
Query: 575 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNG-GTCIDEVDAFRCFCPSGWE---- 629
+ P G+F C+C +GF G+ C E++D+C +P G G C + +F C CP+G+
Sbjct: 688 KNLP-GSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGP 746
Query: 630 GELCDTNPNDCL--PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR---EFQCDAYTCS 684
G C + ++C P PC + GRC + F C C G++ T S +C+ +
Sbjct: 747 GAPCQ-DVDECARSPPPC-TYGRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLAC 804
Query: 685 NGGTCYDSGDTFRC-ACPPG---WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICR 740
G C +S +F+C CP G +G V + SS P PC G C + SF C C
Sbjct: 805 PGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAP-PCGPHGHCTNTEGSFRCSCA 863
Query: 741 DGW---EGR--TCTHNTNDCNPLP-CYNGGICVDGVNWFRCECAPGF----AGPDCRINI 790
G+ GR C + N+C C+ G C++ F C CAPG+ G C +++
Sbjct: 864 PGYRAPSGRPGPCA-DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDV 921
Query: 791 DECQSSPCAYGATCVDEINGYRCSCPPG-RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVE 849
DEC C + + C CPPG RAGP + C RG P GS E
Sbjct: 922 DECSEEDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVD-ECRERG-PALCGSQRCE 979
Query: 850 DC-NSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAW 908
+ S RC+ RDC P AG PE C C E P C CE
Sbjct: 980 NSPGSYRCV---RDCD-------PGYHAG-PE---GTCDDVDECQEYGPEICGAQRCE-- 1023
Query: 909 GECGAEEPPSTPCLP 923
P S C P
Sbjct: 1024 -----NTPGSYRCTP 1033
Score = 192 bits (488), Expect = 2e-48
Identities = 180/621 (28%), Positives = 247/621 (39%), Gaps = 114/621 (18%)
Query: 235 WMGKECKEAVCKQGCNLLHGGCTVPGEC---------RCSYGW----QGRFC---DEC-- 276
W G E E+ G + PG C C G+ QG C DEC
Sbjct: 534 WTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRR 593
Query: 277 VPYPGCVHGSCVEP---WQCNCETNW--GGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQ 330
VP P C G C ++C C + G + D++ C P + G C N P
Sbjct: 594 VP-PPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT-PGS 651
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANG-GSCHEVPSGFECHCPSGWSGPTCALD 385
+ C CP GY G +C+ + CT +P G G+C +P F C CP+G+ G C D
Sbjct: 652 FLCVCPAGYQAAPHGASCQDVDE-CTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 710
Query: 386 IDECASNPCAAG-GTCVDQVDGFECICP----EQWVGATCQLDVNDCRGQ---CQHGGTC 437
+DECA P G G C + F C CP + GA CQ DV++C C + G C
Sbjct: 711 VDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTY-GRC 768
Query: 438 KDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG--- 489
++ +QCVCP GF G CE + DEC + G C + F C CP G
Sbjct: 769 ENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGHHL 827
Query: 490 FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC-PGGACRVI 548
G +VD PC C N EG + C+C + R P G C +
Sbjct: 828 HRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGY--------RAPSGRPGPCADV 879
Query: 549 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENIDDCLG 604
+ C C PHG C++ G+F+C C G+ G C + +D+C
Sbjct: 880 NEC-----------LEGDFCFPHGECLN-TDGSFACTCAPGYRPGPRGASCLD-VDECSE 926
Query: 605 QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP-DPCHSRG-------RCYDLVN 656
+ G C + +F C CP G + CL D C RG RC +
Sbjct: 927 EDLCQSGICTNTDGSFECICP---PGHRAGPDLASCLDVDECRERGPALCGSQRCENSPG 983
Query: 657 DFYCA--CDDGWKG---KTCHSREFQCDAYTCSNGGT--CYDSGDTFRC--ACPPGWK-- 705
+ C CD G+ TC + +C Y G C ++ ++RC AC PG++
Sbjct: 984 SYRCVRDCDPGYHAGPEGTCDDVD-ECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT 1042
Query: 706 -GSTCA---VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNP 757
G C +N S C C SF C+C G+E GR C + N+C
Sbjct: 1043 PGGGCQDVDECRNRSF----CGAHAVCQNLPGSFQCLCDQGYEGARDGRHCV-DVNECET 1097
Query: 758 LPCYNG-GICVDGVNWFRCEC 777
L G +C + F C C
Sbjct: 1098 LQGVCGAALCENVEGSFLCVC 1118
Score = 152 bits (384), Expect = 2e-36
Identities = 191/753 (25%), Positives = 269/753 (35%), Gaps = 181/753 (24%)
Query: 231 CMDGWMGKECKEAV---------CKQG-CNLLHGGCTVPGECRCSYGWQGRF-------C 273
C G+ G C+E V C G C+ G C C G++ R
Sbjct: 698 CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSF----HCACPAGFRSRGPGAPCQDV 753
Query: 274 DECVPYPG-CVHGSCVEP---WQCNC----ETNWGGLLCDKDLNYCGSHHPCTNGGTCIN 325
DEC P C +G C +QC C + N G C+ D++ C +H C G C+N
Sbjct: 754 DECARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACP-GQECVN 811
Query: 326 AEPDQYRC-TCPDGYS---GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPT 381
+ P ++C TCP G+ GR + E + + PC G C F C C G+ P+
Sbjct: 812 S-PGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPS 870
Query: 382 -----CALDIDECASNP-CAAGGTCVDQVDGFECICPEQWV----GATCQLDVNDCRGQ- 430
CA D++EC C G C++ F C C + GA+C LDV++C +
Sbjct: 871 GRPGPCA-DVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEED 928
Query: 431 -CQHGGTCKDLVNGYQCVCPRGFGG----RHCELERDECAS-SPCHSGGL-CEDLADGFH 483
CQ G C + ++C+CP G C L+ DEC P G CE+ +
Sbjct: 929 LCQ-SGICTNTDGSFECICPPGHRAGPDLASC-LDVDECRERGPALCGSQRCENSPGSYR 986
Query: 484 C--HCPQGF-SGP--LCEVDVDLCE---PSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 535
C C G+ +GP C+ DVD C+ P C RC N G Y C C
Sbjct: 987 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCT-------PACDP 1037
Query: 536 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT---- 591
+P PGG C+ +D C + + CG H C + PG +F C+CD G+
Sbjct: 1038 GYQPTPGGGCQDVDECRNRS-----------FCGAHAVCQNLPG-SFQCLCDQGYEGARD 1085
Query: 592 GTYCH-----------------ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 634
G +C EN++ C N D + RC P G
Sbjct: 1086 GRHCVDVNECETLQGVCGAALCENVEGSFLCVCPNSPEEFDPMTG-RCVPPRTSAGTFPG 1144
Query: 635 TNPN---------------------------------DCL-----PDPCHSRGRCYDLVN 656
+ P +C PD C +
Sbjct: 1145 SQPQAPASPVLPARPPPPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQ 1204
Query: 657 DFYCACDDGWKG----KTCHSREFQCDAYTCSNG-GTCYDSGDTFRCACPPGWKGSTCAV 711
+ C +GW + C E C +G G SGD C +
Sbjct: 1205 ECCCTVGEGWGSGCRIQQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR-----DVDECQL 1259
Query: 712 AKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT----CTHNTNDCNPLPCYNGGICV 767
++ C G CV + +SC C +G+ T C N + P GG CV
Sbjct: 1260 FRDQVC------KSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCV 1313
Query: 768 DGVNWFRCECAPGFA--GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
+ V + C C P G R +E QS G C E+ G C + PR
Sbjct: 1314 NTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLG-VCWQEV-GADLVC----SHPRLD 1367
Query: 826 EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 858
+ C +G +W DC C D
Sbjct: 1368 RQATYTECCCL------YGEAWGMDCALCPAQD 1394
Score = 122 bits (307), Expect = 2e-27
Identities = 147/583 (25%), Positives = 212/583 (36%), Gaps = 88/583 (15%)
Query: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
G + E + C + T C ++ H C + C++ +C+
Sbjct: 766 GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP---GQECVNSPGSFQCR--T 820
Query: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP---WQCNCETNW-- 299
C G +L G CT EC C P HG C ++C+C +
Sbjct: 821 CPSGHHLHRGRCTDVDECSSG-------APPCGP-----HGHCTNTEGSFRCSCAPGYRA 868
Query: 300 --GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTS 353
G D+N C C G C+N + + CTC GY G +C + C+
Sbjct: 869 PSGRPGPCADVNECLEGDFCFPHGECLNTD-GSFACTCAPGYRPGPRGASCLDVDE-CSE 926
Query: 354 NPCANGGSCHEVPSGFECHCPSGW-SGPTCA--LDIDECASNPCAAGGT--CVDQVDGFE 408
G C FEC CP G +GP A LD+DEC A G+ C + +
Sbjct: 927 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYR 986
Query: 409 CI--C-PEQWVG--ATCQLDVNDCRG---QCQHGGTCKDLVNGYQCV--CPRGFG---GR 455
C+ C P G TC DV++C+ + C++ Y+C C G+ G
Sbjct: 987 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 1045
Query: 456 HCELERDECAS-SPCHSGGLCEDLADGFHCHCPQGFSGPL----CEVDVDLCEPSPCRNG 510
C+ + DEC + S C + +C++L F C C QG+ G C VDV+ CE G
Sbjct: 1046 GCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCG 1103
Query: 511 AR-CYNLEGDYYCACP------DDFGGKNCSVPREPC---PGGACRVIDGCGSDAG---- 556
A C N+EG + C CP D G+ C PR PG + A
Sbjct: 1104 AALCENVEGSFLCVCPNSPEEFDPMTGR-CVPPRTSAGTFPGSQPQAPASPVLPARPPPP 1162
Query: 557 --PGMPGTAASGVCGPHGR-CVSQPGGNFSC--ICDSGFTGTYCHENIDDCLGQPCRNGG 611
P P T G G R C +C I T C + + G CR
Sbjct: 1163 PLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRIQQ 1222
Query: 612 TCIDEVDAFRCFCPSGW-----EGELC---DTNPNDCLPDPCHSRGRCYDLVNDFYCACD 663
E ++ CP G G+L D + D G C + + C C
Sbjct: 1223 CPGTETAEYQSLCPHGRGYLAPSGDLSLRRDVDECQLFRDQVCKSGVCVNTAPGYSCYCS 1282
Query: 664 DGWKGKT----CHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
+G+ T C + D GG C ++ ++ C C P
Sbjct: 1283 NGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEP 1325
Score = 122 bits (306), Expect = 2e-27
Identities = 183/746 (24%), Positives = 263/746 (35%), Gaps = 168/746 (22%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEK------------------------AEHACT 352
C NGG C+ +PD RC CP ++G+ C+ A H
Sbjct: 157 CHNGGVCV--KPD--RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDD 212
Query: 353 SNPCANGGSCH-EVP--SGFECHCPSGWSGPTCALDIDECASNPCAAG------------ 397
+ A+ S H E P + H SGP D + A AA
Sbjct: 213 EHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQ 272
Query: 398 --------------GTCVDQVDGFECICPEQWV--------GATCQLDVNDCRGQCQHGG 435
G C ++ G EC P + GA V+DC+ + G
Sbjct: 273 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLG 332
Query: 436 TCKDLVNGYQCVCPRGFG--GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493
+ V+ CP GF CE + DECA+ G C + G+ C CP GF
Sbjct: 333 N-SERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGF--- 387
Query: 494 LCEVDVDLCEPSPCRNGAR--CYNLEGDYYCACP--DDFGGKNCSVPRE-PCPGGACRVI 548
L + C + A+ C+ + D C+ P + + C R G C++
Sbjct: 388 LLDSSRSSCISQHVISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLC 447
Query: 549 DGCGSD-------AGPGMPGTAASGVCG-------PHGRCVSQPGGNFSCICDS-GFTGT 593
GS+ AGPG +A+ P +SQP + S GF T
Sbjct: 448 PPFGSEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPT 507
Query: 594 YCHENIDDCLGQPCRNGGTCIDEVDAFRC--FCPSGWEGELCDTNPNDCLPDPCHSRGRC 651
+ E + P + + A+ SG +C NP C P GRC
Sbjct: 508 HRLEPRPEPRPDPRPGPELPLPSIPAWTGPEIPESGPSSGMCQRNPQVCGP------GRC 561
Query: 652 YDLVNDFYCACDDGWKGKTCHSREFQCDAYT-----CSNGGTCYDSGDTFRCACPPGWKG 706
+ + CACD G++ +R D C+ G C +S +FRC C PG++
Sbjct: 562 ISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRA 620
Query: 707 ----STCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNPL 758
+ C +P PC + G C + SF C+C G++ G +C + ++C
Sbjct: 621 GPRAAECLDVDECHRVPPPC-DLGRCENTPGSFLCVCPAGYQAAPHGASC-QDVDECTQS 678
Query: 759 PCYNG-GICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYG-ATCVDEINGYRCSCP 816
P G G C + FRC C GF G C ++DEC P G C + + C+CP
Sbjct: 679 PGLCGRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCGPGRCDNTAGSFHCACP 738
Query: 817 PG----RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP 872
G G CQ+V C P +G C +G C
Sbjct: 739 AGFRSRGPGAPCQDV----DECARSPPPCTYG--------RCENTEGSFQC--------V 778
Query: 873 CLLAGQPEALSAQCP-----------LGQRCLEKAPG--QCLRPP---------CEAWGE 910
C + QP ++C GQ C+ +PG QC P C E
Sbjct: 779 CPMGFQPNTAGSECEDVDECENHLACPGQECV-NSPGSFQCRTCPSGHHLHRGRCTDVDE 837
Query: 911 CGAEEPPSTP---CLPRSGHLDNNCA 933
C + PP P C G +CA
Sbjct: 838 CSSGAPPCGPHGHCTNTEGSFRCSCA 863
Score = 44.7 bits (104), Expect = 5e-04
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 458 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCE----PSPCRNG 510
ELE +EC + G C + +GF C C G+ + VD++ C+ SP
Sbjct: 1531 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590
Query: 511 ARCYNLEGDYYCACPDDF 528
ARC N +G + C C F
Sbjct: 1591 ARCLNTDGSFRCICRPGF 1608
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 336 PDG--YSGRNCE-----KAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALD 385
P+G Y+G E +AE + C NG C VP GF C C G+ +D
Sbjct: 1516 PEGGSYAGSLAEPYEELEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVD 1574
Query: 386 IDEC----ASNPCAAGGTCVDQVDGFECIC 411
I+EC A++P C++ F CIC
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCIC 1604
Score = 38.1 bits (87), Expect = 0.051
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 754 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCR---INIDECQ----SSPCAYGATCVD 806
+C L G CV F C C G+ R ++I+EC +SP A C++
Sbjct: 1536 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLN 1595
Query: 807 EINGYRCSCPPGRA 820
+RC C PG A
Sbjct: 1596 TDGSFRCICRPGFA 1609
Score = 36.6 bits (83), Expect = 0.15
Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 3/33 (9%)
Query: 757 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 789
PL C+NGG+CV RC C P FAG C+++
Sbjct: 154 PLICHNGGVCVKP---DRCLCPPDFAGKFCQLH 183
Score = 35.4 bits (80), Expect = 0.33
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 18/85 (21%)
Query: 683 CSNGGTCYDSGDTFRCACPPGWKG----------STCAVAKNSSCLPNPCVNGGTCVGSG 732
C+NG C + F C C G++ + C A+ +S L CVN C+ +
Sbjct: 1543 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL---CVNA-RCLNTD 1597
Query: 733 ASFSCICRDGWEGRTCTHNTNDCNP 757
SF CICR G+ TH + C P
Sbjct: 1598 GSFRCICRPGF---APTHQPHHCAP 1619
Score = 35.0 bits (79), Expect = 0.43
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 31/115 (26%)
Query: 536 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----T 591
P E C ++DGC +GRCV P G F+C C G+ T
Sbjct: 1528 PYEELEAEECGILDGC------------------TNGRCVRVPEG-FTCRCFDGYRLDMT 1568
Query: 592 GTYCHENIDDC----LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642
C + I++C P C++ +FRC C G+ P+ C P
Sbjct: 1569 RMACVD-INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP---THQPHHCAP 1619
Score = 32.7 bits (73), Expect = 2.1
Identities = 19/81 (23%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQW---VGATCQLDVNDC-----RGQCQHGG 435
L+ +EC G CV +GF C C + + + +D+N+C
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591
Query: 436 TCKDLVNGYQCVCPRGFGGRH 456
C + ++C+C GF H
Sbjct: 1592 RCLNTDGSFRCICRPGFAPTH 1612
Score = 32.7 bits (73), Expect = 2.1
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 18/88 (20%)
Query: 507 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 566
C NG RC + + C C F G + R AC I+ C AAS
Sbjct: 1543 CTNG-RCVRVPEGFTCRC---FDGYRLDMTRM-----ACVDINECDE-------AEAASP 1586
Query: 567 VCGPHGRCVSQPGGNFSCICDSGFTGTY 594
+C + RC++ G +F CIC GF T+
Sbjct: 1587 LC-VNARCLNTDG-SFRCICRPGFAPTH 1612
Score = 31.2 bits (69), Expect = 6.2
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 14/94 (14%)
Query: 274 DECVPYPGCVHGSCV---EPWQCNC----ETNWGGLLCDKDLNYCG---SHHPCTNGGTC 323
+EC GC +G CV E + C C + + C D+N C + P C
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARC 1593
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+N + +RC C G++ + + H + P A
Sbjct: 1594 LNTD-GSFRCICRPGFAPTH--QPHHCAPARPRA 1624
Score = 30.8 bits (68), Expect = 8.1
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 13/59 (22%)
Query: 449 PRGFGGRHC----ELERDECASSP------CHSGGLCEDLADGFHCHCPQGFSGPLCEV 497
PRG GGR +R +P CH+GG+C C CP F+G C++
Sbjct: 127 PRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVC---VKPDRCLCPPDFAGKFCQL 182
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 225 bits (573), Expect = 2e-58
Identities = 113/301 (37%), Positives = 162/301 (53%), Gaps = 24/301 (7%)
Query: 254 GGCTV-PGE----CRCSYGWQGRFCDE---CVPYPGCVHGSCVEP--------WQCNCET 297
G CT P E C C + G FC+E C P + SC++ + C C
Sbjct: 323 GKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLP 382
Query: 298 NWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+ G LC ++YC PC NG TCI++ + C CP+GY G CE+ C S+PC
Sbjct: 383 GYTGELCQSKIDYC-ILDPCRNGATCISSLSG-FTCQCPEGYFGSACEEKVDPCASSPCQ 440
Query: 358 NGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVG 417
N G+C+ F C+C G++GPTCA ID CA +PCA G TC ++C+C + G
Sbjct: 441 NNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCLCDPGYHG 499
Query: 418 ATCQLDVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCE 476
C+ + N+C C + TC+DLVNGY+CVC + G HCEL +D CA+ C +G C+
Sbjct: 500 LYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCD 559
Query: 477 DLADGFH--CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS 534
+DG + C C GF+G C++D++ C+ +PC +G C + Y C CP + G NC
Sbjct: 560 --SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Query: 535 V 535
+
Sbjct: 618 I 618
Score = 223 bits (568), Expect = 8e-58
Identities = 117/343 (34%), Positives = 157/343 (45%), Gaps = 41/343 (11%)
Query: 497 VDVDLCEPSP-------CRNGARCYNL--EGDYYCACPDDFGGKNC----SVPREPCPGG 543
V V C P C +C E + C C + + G C + R+PC
Sbjct: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNN 361
Query: 544 ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL 603
A + DA Q G NF+C+C G+TG C ID C+
Sbjct: 362 ASCI------DANE------------------KQDGSNFTCVCLPGYTGELCQSKIDYCI 397
Query: 604 GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACD 663
PCRNG TCI + F C CP G+ G C+ + C PC + G CY F C C
Sbjct: 398 LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS 457
Query: 664 DGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCV 723
G+ G TC C C++ GTC G +++C C PG+ G C N CL PC+
Sbjct: 458 PGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYN-ECLSAPCL 515
Query: 724 NGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC-VDGVNWFRCECAPGFA 782
N TC + C+C ++G C + C + C NG C DG+N C CAPGF
Sbjct: 516 NAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFT 574
Query: 783 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
G +C I+I+EC S+PC +G +C+D+ NGY C CP G G C+
Sbjct: 575 GEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 199 bits (506), Expect = 1e-50
Identities = 109/328 (33%), Positives = 149/328 (45%), Gaps = 36/328 (10%)
Query: 275 ECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ---- 330
EC C + C CE + G C+ + + C PC N +CI+A Q
Sbjct: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDAC-QRKPCQNNASCIDANEKQDGSN 375
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
+ C C GY+G C+ C +PC NG +C SGF C CP G+ G C +D CA
Sbjct: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
Query: 391 SNPCAAGGTCVDQVDG--FECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCV 447
S+PC GTC VDG F C C + G TC ++ C C H GTC+ + Y+C+
Sbjct: 436 SSPCQNNGTC--YVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCL 492
Query: 448 CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 507
C G+ G +CE E +EC S+PC + C DL +G+ C C + G CE+ D C C
Sbjct: 493 CDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSC 552
Query: 508 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGV 567
NGA C + + C C F G+ C + C D+ P
Sbjct: 553 LNGATCDSDGLNGTCICAPGFTGEECDIDINEC-------------DSNP---------- 589
Query: 568 CGPHGRCVSQPGGNFSCICDSGFTGTYC 595
C G C+ QP G ++C C G+ G C
Sbjct: 590 CHHGGSCLDQPNG-YNCHCPHGWVGANC 616
Score = 192 bits (489), Expect = 1e-48
Identities = 96/314 (30%), Positives = 146/314 (46%), Gaps = 32/314 (10%)
Query: 482 FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE-----GDYYCACPDDFGGKNCSVP 536
F C C + + G CE + D C+ PC+N A C + ++ C C + G+ C
Sbjct: 334 FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
Query: 537 REPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCH 596
+ C ++D C + A C+S G F+C C G+ G+ C
Sbjct: 393 IDYC------ILDPCRNGA-----------------TCISSLSG-FTCQCPEGYFGSACE 428
Query: 597 ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 656
E +D C PC+N GTC + F C C G+ G C + C PC + G C +
Sbjct: 429 EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC-AHGTCRSVGT 487
Query: 657 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS 716
+ C CD G+ G C +C + C N TC D + + C C +KG+ C + K+
Sbjct: 488 SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDP- 546
Query: 717 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 776
C C+NG TC G + +CIC G+ G C + N+C+ PC++GG C+D N + C
Sbjct: 547 CANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCH 606
Query: 777 CAPGFAGPDCRINI 790
C G+ G +C I++
Sbjct: 607 CPHGWVGANCEIHL 620
Score = 123 bits (309), Expect = 9e-28
Identities = 94/324 (29%), Positives = 132/324 (40%), Gaps = 46/324 (14%)
Query: 667 KGKTCHSREFQCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVN 724
K TC E + CS G C S TF C C + G+ C + +C PC N
Sbjct: 303 KVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQN 360
Query: 725 GGTCVGS-----GASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAP 779
+C+ + G++F+C+C G+ G C + C PC NG C+ ++ F C+C
Sbjct: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
Query: 780 GFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGF-------GR 832
G+ G C +D C SSPC TC + + C+C PG GP C ++I F
Sbjct: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
Query: 833 SCWSRGT-------PFPHGSSWVEDCNSC---RCLDGRRDCSKVWCGWKPCLLAG----- 877
+C S GT P HG E+ N C CL+ C + G++ LA
Sbjct: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNA-ATCRDLVNGYECVCLAEYKGTH 539
Query: 878 ----QPEALSAQCPLGQRC-LEKAPGQCLRPPCEAWGECGAE--EPPSTPCLPRSGHLDN 930
+ + C G C + G C+ P EC + E S PC H
Sbjct: 540 CELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPC-----HHGG 594
Query: 931 NCARLTLHFNRDHVPQGTTVGAIC 954
+C +N H P G VGA C
Sbjct: 595 SCLDQPNGYN-CHCPHG-WVGANC 616
Score = 105 bits (263), Expect = 2e-22
Identities = 62/216 (28%), Positives = 98/216 (45%), Gaps = 38/216 (17%)
Query: 197 RCDENYYSATCNKF--------CRPRNDFFG---HYTCDQYGNKACMDGWMGKECKEAVC 245
+C E Y+ + C + C+ + H+TC+ C G+ G C + +
Sbjct: 417 QCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCN------CSPGFTGPTCAQLI- 469
Query: 246 KQGCNL---LHGGCTVPG---ECRCSYGWQGRFCDECVPYPGCVHGSC---------VEP 290
C L HG C G +C C G+ G +C+E Y C+ C V
Sbjct: 470 -DFCALSPCAHGTCRSVGTSYKCLCDPGYHGLYCEE--EYNECLSAPCLNAATCRDLVNG 526
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
++C C + G C+ + C ++ C NG TC +++ C C G++G C+ +
Sbjct: 527 YECVCLAEYKGTHCELYKDPC-ANVSCLNGATC-DSDGLNGTCICAPGFTGEECDIDINE 584
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
C SNPC +GGSC + P+G+ CHCP GW G C + +
Sbjct: 585 CDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL 620
Score = 67.4 bits (163), Expect = 8e-11
Identities = 34/86 (39%), Positives = 42/86 (48%), Gaps = 15/86 (17%)
Query: 351 CTSNPCANGGSC---------HEVPSG---FECHCPSGWSGPTCALDIDECASNPCAAG- 397
C + PC NGG C H P+G + C CP+G SG C L D CASNPC G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 398 --GTCVDQVDGFECICPEQWVGATCQ 421
+ DG+ CIC E + G C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 67.4 bits (163), Expect = 8e-11
Identities = 36/111 (32%), Positives = 48/111 (43%), Gaps = 28/111 (25%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVC 448
CA+ PC GG C + + P+ QH + GY C C
Sbjct: 48 CAAQPCRNGGVCTSRPE------PDP-----------------QHPAPAGE--PGYSCTC 82
Query: 449 PRGFGGRHCELERDECASSPCHSGGL---CEDLADGFHCHCPQGFSGPLCE 496
P G G +C+L D CAS+PCH G +DG+ C C +G+ GP CE
Sbjct: 83 PAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 65.9 bits (159), Expect = 2e-10
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 14/81 (17%)
Query: 316 PCTNGGTCINA-EPDQ----------YRCTCPDGYSGRNCEKAEHACTSNPCANG---GS 361
PC NGG C + EPD Y CTCP G SG NC+ C SNPC +G S
Sbjct: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
Query: 362 CHEVPSGFECHCPSGWSGPTC 382
G+ C C G+ GP C
Sbjct: 112 SSSSSDGYLCICNEGYEGPNC 132
Score = 59.3 bits (142), Expect = 2e-08
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 15/89 (16%)
Query: 755 CNPLPCYNGGICVD------------GVNWFRCECAPGFAGPDCRINIDECQSSPCAYG- 801
C PC NGG+C G + C C G +G +C++ D C S+PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 802 --ATCVDEINGYRCSCPPGRAGPRCQEVI 828
++ +GY C C G GP C++ +
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
Score = 58.5 bits (140), Expect = 4e-08
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 17/96 (17%)
Query: 464 CASSPCHSGGLCEDLAD------------GFHCHCPQGFSGPLCEVDVDLCEPSPCRNG- 510
CA+ PC +GG+C + G+ C CP G SG C++ D C +PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 511 --ARCYNLEGDYYCACPDDFGGKNC--SVPREPCPG 542
+ + Y C C + + G NC ++P P G
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG 143
Score = 55.5 bits (132), Expect = 3e-07
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 17/86 (19%)
Query: 602 CLGQPCRNGGTCIDEVD------------AFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 649
C QPCRNGG C + + C CP+G G C + C +PCH G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HG 106
Query: 650 RCYDLVND----FYCACDDGWKGKTC 671
C + + C C++G++G C
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 52.4 bits (124), Expect = 3e-06
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 16/86 (18%)
Query: 678 CDAYTCSNGGTCYDSGDT------------FRCACPPGWKGSTCAVAKNSSCLPNPCVNG 725
C A C NGG C + + C CP G G+ C + + C NPC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHHG 106
Query: 726 GTCVGSGAS---FSCICRDGWEGRTC 748
S +S + CIC +G+EG C
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 560 PGTAASGVCGPHGRCVSQPGGN-----------FSCICDSGFTGTYCHENIDDCLGQPCR 608
PG A+ C G C S+P + +SC C +G +G C D C PC
Sbjct: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH 104
Query: 609 NG---GTCIDEVDAFRCFCPSGWEGELCD 634
+G + D + C C G+EG C+
Sbjct: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 48.5 bits (114), Expect = 4e-05
Identities = 28/111 (25%), Positives = 36/111 (32%), Gaps = 39/111 (35%)
Query: 502 CEPSPCRNGARCYNL------------EGDYYCACPDDFGGKNCSVPREPCPGGACRVID 549
C PCRNG C + E Y C CP G NC + +PC C
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH--- 104
Query: 550 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN---FSCICDSGFTGTYCHE 597
HG C S + + CIC+ G+ G C +
Sbjct: 105 ---------------------HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 6/95 (6%)
Query: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCV-EP-WQCNCETNWGGLLCDKDLNYCGSH 314
+ PG C G C P P H + EP + C C G C + C S+
Sbjct: 43 SAPGPCAAQPCRNGGVCTSR-PEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
Query: 315 HPCTNGG--TCINAEPDQYRCTCPDGYSGRNCEKA 347
PC +G + ++ D Y C C +GY G NCE+A
Sbjct: 102 -PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/85 (27%), Positives = 31/85 (36%), Gaps = 15/85 (17%)
Query: 717 CLPNPCVNGGTCVG------------SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGG 764
C PC NGG C +SC C G G C + C PC++G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 765 I---CVDGVNWFRCECAPGFAGPDC 786
+ + C C G+ GP+C
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 41.2 bits (95), Expect = 0.006
Identities = 38/135 (28%), Positives = 50/135 (37%), Gaps = 28/135 (20%)
Query: 198 CDENY---YSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECK-------EAVCKQ 247
C+E Y SA C R D Y C C+ + G C+ C
Sbjct: 502 CEEEYNECLSAPCLNAATCR-DLVNGYEC------VCLAEYKGTHCELYKDPCANVSCLN 554
Query: 248 GCNLLHGGCTVPGECRCSYGWQGRFCD----ECVPYPGCVHG-SCVEP---WQCNCETNW 299
G G G C C+ G+ G CD EC P C HG SC++ + C+C W
Sbjct: 555 GATCDSDGLN--GTCICAPGFTGEECDIDINECDSNP-CHHGGSCLDQPNGYNCHCPHGW 611
Query: 300 GGLLCDKDLNYCGSH 314
G C+ L + H
Sbjct: 612 VGANCEIHLQWKSGH 626
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 223 bits (569), Expect = 7e-58
Identities = 144/441 (32%), Positives = 188/441 (42%), Gaps = 69/441 (15%)
Query: 440 LVNGYQCV-CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG-FSGPLCE 496
++ G CV CP G + LE C S C G +D C CP G ++ +
Sbjct: 993 VLRGRMCVNCPLG---TYYNLEHFTCES--CRIGSY-QDEEGQLECKLCPSGMYTEYIHS 1046
Query: 497 VDVDLCEPSPCRNGARCYNLEGDYYC-ACP-----DDFGGKNCSVPREPCPGGACRV--- 547
++ C+ + C+ G Y+ G C +CP FG ++C CP V
Sbjct: 1047 RNISDCK-AQCKQGT--YSYSGLETCESCPLGTYQPKFGSRSCL----SCPENTSTVKRG 1099
Query: 548 ---IDGCGSDAGPGMPGTAASGVCGPHGRCVSQP--GGNFSCICD--------------- 587
I CG G + C P R QP G F C
Sbjct: 1100 AVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITE 1159
Query: 588 -SGFTGTYC------------------HEN----IDDCLGQPCRNGGTCIDEVDAFRCFC 624
S F+ T+ HE +C PC N GTC + C C
Sbjct: 1160 CSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLC 1219
Query: 625 PSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCS 684
P G+ G C+T+ ++C P PC + G C DLV +F C C G+ G+ C +C + C
Sbjct: 1220 PLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCL 1279
Query: 685 NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 744
N G C D +RC C G+ G C N C NPC+N C F C C G+
Sbjct: 1280 NKGICVDGVAGYRCTCVKGFVGLHCETEVNE-CQSNPCLNNAVCEDQVGGFLCKCPPGFL 1338
Query: 745 GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 804
G C N ++C PC NG C DG N FRC CA GF G C +NI+ECQS+PC ATC
Sbjct: 1339 GTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
Query: 805 VDEINGYRCSCPPGRAGPRCQ 825
VDE+N Y C C PG +G RC+
Sbjct: 1399 VDELNSYSCKCQPGFSGKRCE 1419
Score = 211 bits (538), Expect = 3e-54
Identities = 93/220 (42%), Positives = 125/220 (56%), Gaps = 2/220 (0%)
Query: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374
+PC N GTC Y C CP GY+G CE C+ PC N G C ++ F C CP
Sbjct: 1200 NPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP 1258
Query: 375 SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQH 433
SG++G C +I+EC+S+PC G CVD V G+ C C + +VG C+ +VN+C+ C +
Sbjct: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLN 1318
Query: 434 GGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493
C+D V G+ C CP GF G C DEC S PC +G C+D A+ F C C GF+G
Sbjct: 1319 NAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGS 1378
Query: 494 LCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533
CE++++ C+ +PCRN A C + Y C C F GK C
Sbjct: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
Score = 197 bits (502), Expect = 4e-50
Identities = 93/248 (37%), Positives = 122/248 (49%), Gaps = 25/248 (10%)
Query: 349 HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408
H C NPC N G+C ++ G+ C CP G++G C DIDEC+ PC G C D V F
Sbjct: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
Query: 409 CICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS 467
C CP + G C+ ++N+C C + G C D V GY+C C +GF G HCE E +EC S+
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
Query: 468 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 527
PC + +CED GF C CP GF G C +VD C PC+NGA C + + C C
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
Query: 528 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 587
F G +C + C CR CV + ++SC C
Sbjct: 1375 FTGSHCELNINECQSNPCR-----------------------NQATCVDEL-NSYSCKCQ 1410
Query: 588 SGFTGTYC 595
GF+G C
Sbjct: 1411 PGFSGKRC 1418
Score = 197 bits (500), Expect = 7e-50
Identities = 90/228 (39%), Positives = 129/228 (56%), Gaps = 6/228 (2%)
Query: 275 ECVPYPGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQY 331
EC P G+C + + C C + GL C+ D++ C S PC N G C + ++
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC-SPLPCLNNGVCKDLV-GEF 1253
Query: 332 RCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECAS 391
C CP GY+G+ CE+ + C+S+PC N G C + +G+ C C G+ G C +++EC S
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
Query: 392 NPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCPR 450
NPC C DQV GF C CP ++G C +V++C Q C++G TCKD N ++C+C
Sbjct: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
Query: 451 GFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 498
GF G HCEL +EC S+PC + C D + + C C GFSG CE +
Sbjct: 1374 GFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 188 bits (478), Expect = 2e-47
Identities = 83/253 (32%), Positives = 115/253 (45%), Gaps = 24/253 (9%)
Query: 463 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 522
EC +PCH+ G C+ L G+ C CP G++G CE D+D C P PC N C +L G++ C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
Query: 523 ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 582
CP + G+ C C C G GV G +
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCL------------NKGICVDGVAG------------Y 1291
Query: 583 SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 642
C C GF G +C +++C PC N C D+V F C CP G+ G C N ++CL
Sbjct: 1292 RCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLS 1351
Query: 643 DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 702
PC + C D N F C C G+ G C +C + C N TC D +++ C C P
Sbjct: 1352 QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQP 1411
Query: 703 GWKGSTCAVAKNS 715
G+ G C +++
Sbjct: 1412 GFSGKRCETEQST 1424
Score = 178 bits (451), Expect = 3e-44
Identities = 81/208 (38%), Positives = 113/208 (54%), Gaps = 10/208 (4%)
Query: 262 CRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGSH 314
C C G+ G C DEC P P +G C V + C C + + G C++++N C S
Sbjct: 1217 CLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSS 1276
Query: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374
PC N G C++ YRCTC G+ G +CE + C SNPC N C + GF C CP
Sbjct: 1277 -PCLNKGICVDGVAG-YRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCP 1334
Query: 375 SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQH 433
G+ G C ++DEC S PC G TC D + F C+C + G+ C+L++N+C+ C++
Sbjct: 1335 PGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRN 1394
Query: 434 GGTCKDLVNGYQCVCPRGFGGRHCELER 461
TC D +N Y C C GF G+ CE E+
Sbjct: 1395 QATCVDELNSYSCKCQPGFSGKRCETEQ 1422
Score = 82.8 bits (203), Expect = 2e-15
Identities = 98/374 (26%), Positives = 134/374 (35%), Gaps = 42/374 (11%)
Query: 580 GNFSC-ICDSGFTGTYCHE-NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 637
G C +C SG Y H NI DC Q C+ G ++ CP G +
Sbjct: 1028 GQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCES-CPLGTYQPKFGSR- 1084
Query: 638 NDCLPDPCHSRGRCYDLVNDFYCA--CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT 695
CL P ++ VN C C +G SR + C ++G
Sbjct: 1085 -SCLSCPENTSTVKRGAVNISACGVPCPEGK-----FSRSGLMPCHPCPRDYYQPNAGKA 1138
Query: 696 FRCACPPGWKGSTCAVAKNS----SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 751
F ACP + G+T S S + V AS I + H
Sbjct: 1139 FCLACP--FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFH- 1195
Query: 752 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811
+C PC+N G C + C C G+ G C +IDEC PC C D + +
Sbjct: 1196 --ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEF 1253
Query: 812 RCSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSK 865
C CP G G RC+E I S C ++G + + C C+ G +
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGY-----RCTCVKGFVGLHCETEV 1308
Query: 866 VWCGWKPCL----LAGQPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWGECGAEEPPS 918
C PCL Q +CP LG RC K +CL PC+ C + S
Sbjct: 1309 NECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRC-GKNVDECLSQPCKNGATC-KDGANS 1366
Query: 919 TPCLPRSGHLDNNC 932
CL +G ++C
Sbjct: 1367 FRCLCAAGFTGSHC 1380
Score = 82.4 bits (202), Expect = 2e-15
Identities = 44/133 (33%), Positives = 62/133 (46%), Gaps = 14/133 (10%)
Query: 218 FGHYTCDQYGNKACMDG--WMGKECKEAVCKQGCNLLHGG-CTVPGECRCSYGWQGRFCD 274
+ Y + + C++ W AVC+ C +GG C P C C GW GR C+
Sbjct: 3443 YSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQ--NGGICQRPNACSCPEGWMGRLCE 3500
Query: 275 ECVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333
E + C++G CV P+QC+C W G C + C S PC NGG C+ RC
Sbjct: 3501 EPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAV--CQS--PCLNGGKCVRPN----RC 3552
Query: 334 TCPDGYSGRNCEK 346
C ++G NC +
Sbjct: 3553 HCLSSWTGHNCSR 3565
Score = 80.1 bits (196), Expect = 1e-14
Identities = 56/167 (33%), Positives = 74/167 (44%), Gaps = 36/167 (21%)
Query: 220 HYTCDQYGNK---ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDEC 276
HY QYG+ +C G+M + +VC L +G T P CR
Sbjct: 3431 HY---QYGDMITYSCYSGYMLEGFLRSVC-----LENGTWTSPPICRA-----------V 3471
Query: 277 VPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
+P G C P C+C W G LC++ + PC NGG C+ Y+C CP
Sbjct: 3472 CRFPCQNGGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRCVAP----YQCDCP 3523
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383
G++G C A C S PC NGG C P+ CHC S W+G C+
Sbjct: 3524 PGWTGSRCHTA--VCQS-PCLNGGKCVR-PN--RCHCLSSWTGHNCS 3564
Score = 74.7 bits (182), Expect = 5e-13
Identities = 40/105 (38%), Positives = 49/105 (46%), Gaps = 16/105 (15%)
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPS 375
PC NGG C C+CP+G+ GR CE E C PC NGG C + ++C CP
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCE--EPICIL-PCLNGGRC---VAPYQCDCPP 3524
Query: 376 GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
GW+G C + +PC GG CV C C W G C
Sbjct: 3525 GWTGSRCHTAV---CQSPCLNGGKCVRP---NRCHCLSSWTGHNC 3563
Score = 72.0 bits (175), Expect = 3e-12
Identities = 37/106 (34%), Positives = 49/106 (46%), Gaps = 16/106 (15%)
Query: 644 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 703
PC + G C C+C +GW G+ C E C NGG C ++C CPPG
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLC---EEPICILPCLNGGRCVAP---YQCDCPPG 3525
Query: 704 WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCT 749
W GS C +++ +PC+NGG CV C C W G C+
Sbjct: 3526 WTGSRC----HTAVCQSPCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
Score = 71.6 bits (174), Expect = 4e-12
Identities = 42/105 (40%), Positives = 49/105 (46%), Gaps = 15/105 (14%)
Query: 606 PCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDG 665
PC+NGG C +A C CP GW G LC+ P L PC + GRC V + C C G
Sbjct: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCE-EPICIL--PCLNGGRC---VAPYQCDCPPG 3525
Query: 666 WKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 710
W G CH+ Q C NGG C RC C W G C+
Sbjct: 3526 WTGSRCHTAVCQS---PCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
Score = 69.3 bits (168), Expect = 2e-11
Identities = 56/184 (30%), Positives = 67/184 (36%), Gaps = 37/184 (20%)
Query: 660 CACDDGWKGKTCHSREFQCD----AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 715
C D+ W + + C G Y GD +C + G S
Sbjct: 3398 CNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSC---YSGYMLEGFLRS 3454
Query: 716 SCLPN---------------PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760
CL N PC NGG C A C C +GW GR C C LPC
Sbjct: 3455 VCLENGTWTSPPICRAVCRFPCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CI-LPC 3508
Query: 761 YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRA 820
NGG CV ++C+C PG+ G C + CQ SPC G CV RC C
Sbjct: 3509 LNGGRCVAP---YQCDCPPGWTGSRCHTAV--CQ-SPCLNGGKCV---RPNRCHCLSSWT 3559
Query: 821 GPRC 824
G C
Sbjct: 3560 GHNC 3563
Score = 68.2 bits (165), Expect = 5e-11
Identities = 41/111 (36%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 427 CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 486
CR CQ+GG C+ C CP G+ GR CE + PC +GG C + C C
Sbjct: 3472 CRFPCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDC 3522
Query: 487 PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 537
P G++G C V C+ SPC NG +C C C + G NCS R
Sbjct: 3523 PPGWTGSRCHTAV--CQ-SPCLNGGKCVR---PNRCHCLSSWTGHNCSRKR 3567
Score = 62.0 bits (149), Expect = 3e-09
Identities = 37/103 (35%), Positives = 45/103 (43%), Gaps = 14/103 (13%)
Query: 393 PCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGF 452
PC GG C C CPE W+G C+ + C C +GG C V YQC CP G+
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPI--CILPCLNGGRC---VAPYQCDCPPGW 3526
Query: 453 GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 495
G C SPC +GG C CHC ++G C
Sbjct: 3527 TGSRC---HTAVCQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
Score = 58.5 bits (140), Expect = 4e-08
Identities = 47/167 (28%), Positives = 61/167 (36%), Gaps = 47/167 (28%)
Query: 469 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 528
C+SG + E S P+C +C PC+NG C C+CP+ +
Sbjct: 3442 CYSGYMLEGFLRSVCLENGTWTSPPICRA---VCR-FPCQNGGICQRPNA---CSCPEGW 3494
Query: 529 GGKNCSVPR--EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 586
G+ C P PC G GRCV+ + C C
Sbjct: 3495 MGRLCEEPICILPCLNG----------------------------GRCVAP----YQCDC 3522
Query: 587 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
G+TG+ CH + PC NGG C V RC C S W G C
Sbjct: 3523 PPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 468 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 527
PC +GG+C+ C CP+G+ G LCE + + PC NG RC Y C CP
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCV---APYQCDCPPG 3525
Query: 528 FGGKNC--SVPREPC-PGGAC 545
+ G C +V + PC GG C
Sbjct: 3526 WTGSRCHTAVCQSPCLNGGKC 3546
Score = 49.7 bits (117), Expect = 2e-05
Identities = 39/109 (35%), Positives = 45/109 (41%), Gaps = 20/109 (18%)
Query: 759 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 818
PC NGGIC C C G+ G C I C PC G CV Y+C CPPG
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPI--C-ILPCLNGGRCVAP---YQCDCPPG 3525
Query: 819 RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG--RRDCSK 865
G RC + C S P +G V N C CL +CS+
Sbjct: 3526 WTGSRCHTAV-----CQS---PCLNGGKCVRP-NRCHCLSSWTGHNCSR 3565
Score = 44.3 bits (103), Expect = 7e-04
Identities = 41/142 (28%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 653 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC------YDSGDTFRC-ACPPGWK 705
D+V+ Y CD+G K C R C T + C Y G + C ACP G
Sbjct: 273 DMVHCSYL-CDEG---KDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTY 328
Query: 706 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 765
+ SSC+P P N + GS + C+CR+G+ T C L G
Sbjct: 329 KPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGY 388
Query: 766 CVDGV--NWFRCECA----PGF 781
+ N F C PGF
Sbjct: 389 FIQNTCNNHFNAACGVRCHPGF 410
Score = 39.3 bits (90), Expect = 0.023
Identities = 63/281 (22%), Positives = 93/281 (33%), Gaps = 30/281 (10%)
Query: 474 LCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 533
L EDL G LC+ D C+ +C G + C C + GK
Sbjct: 260 LHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRM---GSCKCGTHTGHFECICEKGYYGKGL 316
Query: 534 SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF--SCICDSGF- 590
CP G + G PG +S + P S PG C+C G+
Sbjct: 317 QYECTACPSGTYK---------PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYR 367
Query: 591 -TGTYCHENIDDCLGQPCRNG----GTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDP 644
+G C E + +P NG TC + + A C G+ +L ++ CLP+
Sbjct: 368 ASGQTC-ELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPNG 424
Query: 645 CHSRGRCYDLVNDFYCACDDGWKGKTCHSRE--FQCDAYTCSNGGTCYDSGDTFRCACPP 702
S Y V +C +RE ++ + G + D C
Sbjct: 425 LWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNS 484
Query: 703 GWKG-STCAVAKNSSCLPNP---CVNGGTCVGSGASFSCIC 739
W G V ++ S P ++ C A F IC
Sbjct: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
Score = 38.5 bits (88), Expect = 0.039
Identities = 21/47 (44%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 493 PLCEVDVDLCEP-SPCRNGARCYNLEGDYYCAC--PDDFGGKNCSVP 536
P C +DVD C S C A C N++G Y C+C P GKNC+ P
Sbjct: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEP 1786
Score = 37.7 bits (86), Expect = 0.066
Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 15/103 (14%)
Query: 741 DGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ-SSPCA 799
D + G T T+ N+ L + C D +W P C +++DEC S C+
Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSW-------NGVSPSC-LDVDECAVGSDCS 1756
Query: 800 YGATCVDEINGYRCSCPPGRA--GPRCQEVIGFGRSCWSRGTP 840
A+C++ Y CSC P G C E I C + G P
Sbjct: 1757 EHASCLNVDGSYICSCVPPYTGDGKNCAEPI----KCKAPGNP 1795
Score = 35.4 bits (80), Expect = 0.33
Identities = 42/192 (21%), Positives = 66/192 (34%), Gaps = 27/192 (14%)
Query: 570 PHGRCVSQ---PGGNFSCICDSGFTGTYCHENIDDCLGQP---CRNGGTC---IDEVDAF 620
PH R S+ PG + CD GF +G P C N G + +
Sbjct: 1639 PHLRTASEDLKPGSKVNLFCDPGF----------QLVGNPVQYCLNQGQWTQPLPHCERI 1688
Query: 621 RCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND--FYCACDDGWKG--KTCHSREF 676
C P E + + Y L+ D +C + W G +C +
Sbjct: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDE 1748
Query: 677 QCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC-LPNPCVNG---GTCVGSG 732
CS +C + ++ C+C P + G A+ C P NG G G
Sbjct: 1749 CAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808
Query: 733 ASFSCICRDGWE 744
A + C++G++
Sbjct: 1809 AEVTFSCQEGYQ 1820
Score = 31.6 bits (70), Expect = 4.7
Identities = 27/109 (24%), Positives = 41/109 (37%), Gaps = 28/109 (25%)
Query: 417 GATCQLDVNDCRGQCQHGGTCKDLVNG---------YQCVCPRGFGGRHCELERDECASS 467
G+ Q D+ C C G C D + ++C+C +G+ G+ + E C S
Sbjct: 267 GSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSG 326
Query: 468 PC----HSGGL--CEDLADGFH-----------CHCPQGF--SGPLCEV 497
GG+ C D H C C +G+ SG CE+
Sbjct: 327 TYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375
Score = 31.6 bits (70), Expect = 4.7
Identities = 26/99 (26%), Positives = 34/99 (34%), Gaps = 6/99 (6%)
Query: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC 362
LCD+ + C C G + C C GY G+ + AC S GS
Sbjct: 280 LCDEGKDCCDRMGSCKCG-----THTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
Query: 363 HEVPSGFECHCPSGWSGPTCALDID-ECASNPCAAGGTC 400
+ S C + S P D C A+G TC
Sbjct: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC 373
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 221 bits (562), Expect = 4e-57
Identities = 209/718 (29%), Positives = 265/718 (36%), Gaps = 161/718 (22%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQG 248
CD ++ C+ C N GH +CD G C G++G C++ C+Q
Sbjct: 860 CDTGHWGPDCSHPC---NCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQR 916
Query: 249 CNLLHGGCT--VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDK 306
C HG V G C C GW+G FC+ P G C CNC G CD
Sbjct: 917 CQCQHGAACDHVSGACTCPAGWRGTFCEHACP-AGFFGLDCRS--ACNCT---AGAACD- 969
Query: 307 DLNYCGSHHPCTNGGTCINAEPDQYRC--TCPDGYSGRNCEKAEHACTSNPCANGGSCHE 364
NG A RC TCP G NC + AC C NG SC
Sbjct: 970 ----------AVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQ---ACA---CFNGASCDP 1013
Query: 365 VPSGFECHCPSGWSGPTC------ALDIDECA-SNPCAAGGTCVDQVDGFECICPEQWVG 417
V +CHC GW GP+C L D C S C GGTC D V G C CPE W G
Sbjct: 1014 VHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTC-DPVSG-HCACPEGWAG 1069
Query: 418 ATCQLDV--NDCRGQCQHGGTCKDLVNG-------YQCVCPRGFGGRHCELE------RD 462
C+ + D R C+H G C +NG +C+CP G+ G C+ +
Sbjct: 1070 LACEKECLPRDVRAGCRHSGGC---LNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGE 1126
Query: 463 ECAS-SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY 521
CA C G C + C CP GF+G CE C P G C +
Sbjct: 1127 ACAQRCSCPPGAACHHVTGA--CRCPPGFTGSGCE---QACPPGSF--GEDCAQM----- 1174
Query: 522 CACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCG--PHGRCVSQPG 579
C CP + C C A C PG G +CG G C + G
Sbjct: 1175 CQCPGE--NPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATG 1232
Query: 580 GNFSCICDSGFTGTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCPSGWEGEL 632
+C C +GF GT C+ P C G C D V C CP G G
Sbjct: 1233 ---ACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC-DPVTG-TCLCPPGRAGVR 1287
Query: 633 CDTN----------PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD--- 679
C+ + C C + G C+ ++ C+C GW G+ C E C
Sbjct: 1288 CERGCPQNRFGVGCEHTC---SCRNGGLCH--ASNGSCSCGLGWTGRHC---ELACPPGR 1339
Query: 680 -------AYTCSNGGTCYDSGDTFRCA-----------CPPGWKGSTCAVAKNSSCLPNP 721
+C N TC + T RC CPPG+ G+ C C
Sbjct: 1340 YGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGC----QGLCW--- 1392
Query: 722 CVNGGTCVGSGASFSCICRDGWEGRTCTHNT------NDCNPLPCYNGGICVDGVNWFRC 775
C +G C S C+C G+ G C C+ +GG D V C
Sbjct: 1393 CQHGAPC--DPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGL-C 1449
Query: 776 ECAPGFAGPDCRINIDECQSSP-------CAYGATCVDEINGYRCSCPPGRAGPRCQE 826
C PG +G C ++ Q P C GA C D ++G +C C G GP C+E
Sbjct: 1450 LCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADC-DPVSG-QCHCVDGYMGPTCRE 1505
Score = 211 bits (538), Expect = 3e-54
Identities = 228/829 (27%), Positives = 300/829 (36%), Gaps = 197/829 (23%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHY-----------TCDQY-GNKACMDGWMGKECKEAV- 244
C E + CN+ C P D FG TCD G C G G C++
Sbjct: 542 CPEGWTGLICNETCPP--DTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCP 599
Query: 245 -------CKQGCNLLHGG-C-TVPGECRCSYGWQGRFCD-ECVPY---PGCVHG-SCVEP 290
C++ CN + G C + G C C G GRFC C P+ PGC CV+P
Sbjct: 600 KGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQP 659
Query: 291 W---------QCNCETNWGGLLCDKD--LNY----CGSHHPCTNGGTCINAEPDQYRCTC 335
C+C+ + G C + L Y C C G C + + + C
Sbjct: 660 HTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGK-RC 718
Query: 336 PDGYSGRNCEKAEHA------CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE- 388
P G+ G +C + C+S+ G CH V +C CP G +G C D E
Sbjct: 719 PAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCEADCPEG 776
Query: 389 ----------------CASNPCAAGGTCVDQVDGFEC--ICPEQWVGATCQLDVNDCRGQ 430
+P C+ G C +CP W G +CQ R
Sbjct: 777 RWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQT-----RCS 831
Query: 431 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERD------ECASSPCHSGG----------- 473
C + G C C C G+ G C+ D +C S PC+
Sbjct: 832 CANDGHCHPATG--HCSCAPGWTGFSCQRACDTGHWGPDC-SHPCNCSAGHGSCDAISGL 888
Query: 474 -LCEDLADGFHCH--CPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC-------- 522
LCE G C CPQG GP CE + C++GA C ++ G C
Sbjct: 889 CLCEAGYVGPRCEQQCPQGHFGPGCE------QRCQCQHGAACDHVSGACTCPAGWRGTF 942
Query: 523 ---ACPDDFGGKNCSVPREPCPGGACRVIDG-CGSDAGPGMPGTAASGVCGPHGRCVSQP 578
ACP F G +C G AC ++G C AG P A + +G SQ
Sbjct: 943 CEHACPAGFFGLDCRSACNCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQ- 1001
Query: 579 GGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPN 638
+C C F G C C P G +C+ CP+G G+ C +
Sbjct: 1002 ----ACAC---FNGASCDPVHGQCHCAPGWMGPSCLQA-------CPAGLYGDNCR---H 1044
Query: 639 DCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT-CSNGGTCYDSG---- 693
CL C + G C D V+ +CAC +GW G C D C + G C + G
Sbjct: 1045 SCL---CQNGGTC-DPVSG-HCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDP 1099
Query: 694 DTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTN 753
T RC CP GW G C +PC+ G G + C C G C H T
Sbjct: 1100 HTGRCLCPAGWTGDKCQ---------SPCLRGW--FGEACAQRCSCPPG---AACHHVTG 1145
Query: 754 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGAT----CVDEIN 809
C P + G C C PG G DC +P + AT C +
Sbjct: 1146 ACRCPPGFTGSGCEQA-------CPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYH 1198
Query: 810 GYRCS--CPPGRAGPRCQEVIGF--GRSCWSRGTPFPHGSSWV-EDCNSCRCLDGR--RD 862
G C CPPGR GP C+++ G G SC + + ++ DCN C GR +
Sbjct: 1199 GPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCN-LTCPQGRFGPN 1257
Query: 863 CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGEC 911
C+ V CG C G C + G CL PP A C
Sbjct: 1258 CTHV-CG----------------CGQGAAC-DPVTGTCLCPPGRAGVRC 1288
Score = 206 bits (525), Expect = 8e-53
Identities = 238/849 (28%), Positives = 301/849 (35%), Gaps = 214/849 (25%)
Query: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCV 288
C+D G +C C+ G L G + G C C GW G C+E P P +C
Sbjct: 511 CLDDSFGHDCSLTCDDCRNGGTCLLG---LDG-CDCPEGWTGLICNETCP-PDTFGKNC- 564
Query: 289 EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK-- 346
+ C+C+ NGGTC + C CP G SG NCE
Sbjct: 565 -SFSCSCQ----------------------NGGTCDSVTG---ACRCPPGVSGTNCEDGC 598
Query: 347 -----AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP-CAAGGTC 400
+H CAN G CH + C C G G C L A P C+ C
Sbjct: 599 PKGYYGKHCRKKCNCANRGRCHRLYGA--CLCDPGLYGRFCHLTCPPWAFGPGCSEECQC 656
Query: 401 V-------DQVDGFECICPEQWVGATCQLDVN------DCRGQCQ-HGGTCKDLVNGYQC 446
V D+ DG C C + G CQ + C C G D V+G +C
Sbjct: 657 VQPHTQSCDKRDG-SCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSG-EC 714
Query: 447 --VCPRGFGGRHCELERD------ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 498
CP GF G C E C+SS G C + C CP G +G CE D
Sbjct: 715 GKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCEAD 772
Query: 499 V----------DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGG----A 544
++C C++ ARC G C C F G C ++ CP G +
Sbjct: 773 CPEGRWGLGCQEIC--PACQHAARCDPETG--ACLCLPGFVGSRC---QDVCPAGWYGPS 825
Query: 545 CRVIDGCGSD-----------AGPGMPGTAASGVC-----GP-----------HGRCVSQ 577
C+ C +D PG G + C GP HG C +
Sbjct: 826 CQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAI 885
Query: 578 PGGNFSCICDSGFTGTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCPSGWEG 630
G C+C++G+ G C + P C++G C D V C CP+GW G
Sbjct: 886 SG---LCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAAC-DHVSG-ACTCPAGWRG 940
Query: 631 ELCD-TNPNDCLPDPCHSRGRC-----YDLVNDFYCACDDGWKGKTC------HSREFQC 678
C+ P C S C D VN C C G +G C H+ C
Sbjct: 941 TFCEHACPAGFFGLDCRSACNCTAGAACDAVNG-SCLCPAGRRGPRCAETCPAHTYGHNC 999
Query: 679 -DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVA---------KNSSCLPNPCVNGGTC 728
A C NG +C +C C PGW G +C A SCL C NGGTC
Sbjct: 1000 SQACACFNGASCDPVHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSCL---CQNGGTC 1054
Query: 729 VGSGASFSCICRDGWEGRTCTHNTNDCNPLP----------CYNGGICVDGVNWFRCECA 778
S C C +GW G C +C P C NGG+C RC C
Sbjct: 1055 --DPVSGHCACPEGWAGLAC---EKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLCP 1107
Query: 779 PGFAGPDCRINI------DEC-QSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI--- 828
G+ G C+ + C Q C GA C + G C CPPG G C++
Sbjct: 1108 AGWTGDKCQSPCLRGWFGEACAQRCSCPPGAAC-HHVTG-ACRCPPGFTGSGCEQACPPG 1165
Query: 829 GFGRSCWSR-----GTPFPHGSSWVEDC------NSC--RCLDGR--RDCSKVWCGWKPC 873
FG C P H ++ C SC RC GR C ++ CG C
Sbjct: 1166 SFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQL-CG---C 1221
Query: 874 LLAGQPEALSAQCP-----LGQRCLEKAPGQCLRPPCEAWGECG---AEEPPSTPCLPRS 925
L G +A + C LG C P P C CG A +P + CL
Sbjct: 1222 LNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPP 1281
Query: 926 GHLDNNCAR 934
G C R
Sbjct: 1282 GRAGVRCER 1290
Score = 168 bits (426), Expect = 2e-41
Identities = 189/679 (27%), Positives = 252/679 (37%), Gaps = 169/679 (24%)
Query: 344 CEKAEHACTSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402
C AE C+++ C +GG C VP + CHCP G+ GP C D+DEC ++ CV+
Sbjct: 123 CLSAE--CSASLCFHGGRC--VPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVN 178
Query: 403 QVDGFECICPEQW----VGATCQLDVNDC---RGQCQHGGTCKDL-VNGYQCVCPRGF-- 452
+ C C + TC L +N C G CQH C L + ++C C GF
Sbjct: 179 TPGSYLCECKPGFRLHTDSRTC-LAINSCALGNGGCQH--HCVQLTITRHRCQCRPGFQL 235
Query: 453 --GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCEPSP 506
GRHC + R CA+ C+ + C C G+ G CE DVD C
Sbjct: 236 QEDGRHC-VRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACE-DVDECAAGL 293
Query: 507 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG---PGMPGTA 563
+ C N +G + C C G C +++ C ++ G G T+
Sbjct: 294 AQCAHGCLNTQGSFKCVC---HAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTS 350
Query: 564 ASGVCG-PHGR------------------------CVSQPGGNFSCICDSGF----TGTY 594
A +C P G C + PGG + C C +G+ G
Sbjct: 351 AGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTNNPGG-YECGCYAGYRLSADGCG 409
Query: 595 CHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW-------------------EGELCDT 635
C E++D+C C + +F+C C +G+ +GEL
Sbjct: 410 C-EDVDECASSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFV 468
Query: 636 NP-------NDCLP------------DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 676
P D LP + RG + L F C DD + G C
Sbjct: 469 RPLPHIAVLQDELPQLFQDDDVGADEEEAELRGE-HTLTEKFVC-LDDSF-GHDC---SL 522
Query: 677 QCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 736
CD C NGGTC D C CP GW G C N +C P+ G SFS
Sbjct: 523 TCD--DCRNGGTCLLGLD--GCDCPEGWTGLIC----NETCPPD-------TFGKNCSFS 567
Query: 737 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 796
C C++ G TC T C P +G C DG C G+ G CR +
Sbjct: 568 CSCQN---GGTCDSVTGACRCPPGVSGTNCEDG-------CPKGYYGKHCRKKCNCANRG 617
Query: 797 PC--AYGA-TCVDEINGYRC--SCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDC 851
C YGA C + G C +CPP GP C E C PH S +
Sbjct: 618 RCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEEC----QCVQ-----PHTQSCDKRD 668
Query: 852 NSCRCLDGRR------DCSKVWCG---WKPCLLAGQPEALSAQCPLGQRCLEKAPGQC-L 901
SC C G R +C + G W+ C CP+G C + G+C
Sbjct: 669 GSCSCKAGFRGERCQAECELGYFGPGCWQAC-----------TCPVGVAC-DSVSGECGK 716
Query: 902 RPPCEAWGE-CGAEEPPST 919
R P GE CG E P T
Sbjct: 717 RCPAGFQGEDCGQECPVGT 735
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 219 bits (558), Expect = 1e-56
Identities = 220/745 (29%), Positives = 272/745 (36%), Gaps = 191/745 (25%)
Query: 274 DECVPY--PGCVHGSCVEPWQCNCETNWGGLLCDKDLN------YCGSHHPCTNGGTCIN 325
D C+P CVHG CV P C+CE WGG C + +C + C NG C
Sbjct: 97 DFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALC-- 154
Query: 326 AEPDQYRCTCPDGYSGRNCEKAEHACTSN-------PCANGGSCHEVPSGFECHCPSGWS 378
P C C G+ G CE+ T C +G SC P EC C G++
Sbjct: 155 -NPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCD--PRAGECLCAPGYT 211
Query: 379 GPTCALDIDECASN----------PCAAGGTCVDQVDGFECICPEQWVGATC-------- 420
G C + C PC GGTC + G EC CP W GA C
Sbjct: 212 GVYCE---ELCPPGSHGAHCELRCPCQNGGTC-HHITG-ECACPPGWTGAVCAQPCPPGT 266
Query: 421 --QLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD------ECAS-SPCHS 471
Q DC C HGG C D V G QC C G+ G C+ E +C+ CH+
Sbjct: 267 FGQNCSQDC--PCHHGGQC-DHVTG-QCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHN 322
Query: 472 GGLCEDLADGFHCH------------CPQGFSGPLCEVDVDLCEPSPC--RNGARCYNLE 517
GG C C CP+G GP C + P PC N C+ +
Sbjct: 323 GGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTL------PCPCDADNTISCHPVT 376
Query: 518 GDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ 577
G C C + G +C+ E CP G DGC +P T +G C S
Sbjct: 377 G--ACTCQPGWSGHHCN---ESCPVGYYG--DGC------QLPCTCQNG-----ADCHSI 418
Query: 578 PGGNFSCICDSGFTGTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCPSGWEG 630
GG C C GF G C + P C NGGTC VD C C GW+G
Sbjct: 419 TGG---CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTC-SPVDG-SCTCKEGWQG 473
Query: 631 ELC---------DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAY 681
C N N+ C + C + D C+C GW G TC E C
Sbjct: 474 LDCTLPCPSGTWGLNCNESC--TCANGAACSPI--DGSCSCTPGWLGDTC---ELPCPDG 526
Query: 682 T----CSNGGTCYDSGD----TFRCACPPGWKGSTCAVAKNSSCLPN----------PCV 723
T CS C + T C C GW G C +S+C P C
Sbjct: 527 TFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRC----DSTCPPGRWGPNCSVSCSCE 582
Query: 724 NGGTCVGSGASFSC-----------ICRDGWEGRTCTHNTNDC--NPLPCYNGGICVDGV 770
NGG+C S C IC G+ G C C + PC++ + G+
Sbjct: 583 NGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHH----ISGI 638
Query: 771 NWFRCECAPGFAGPDCR-------INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPR 823
CEC PGF+G C D Q CA TC I+G C C PG G
Sbjct: 639 ----CECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTC-SPIDG-SCQCFPGWIGKD 692
Query: 824 CQEVI--GF-GRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGW-----KPCLL 875
C + GF G +C+ H S + SC DG C+ W G P
Sbjct: 693 CSQACPPGFWGPACF-------HACS-CHNGASCSAEDGACHCTPGWTGLFCTQRCPAAF 744
Query: 876 AGQPEALSAQCPLGQRCLEKAPGQC 900
G+ QC G C + G+C
Sbjct: 745 FGKDCGRVCQCQNGASC-DHISGKC 768
Score = 214 bits (546), Expect = 3e-55
Identities = 213/782 (27%), Positives = 285/782 (36%), Gaps = 192/782 (24%)
Query: 195 RVRCDENYYSATCNKFCRPR-NDFFGHYTCDQYGNKACMDGWMGKECKEAV--------C 245
R +C YY + FC P + H C C GW G +C C
Sbjct: 85 RSQCCPGYYES--GDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHC 142
Query: 246 KQGCNLLHGGCTVP--GECRCSYGWQGRFCDE-CVPYPG---------CVHGSCVEP--W 291
C +G P G C C+ G++G C+E C P C HG+ +P
Sbjct: 143 SNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAG 202
Query: 292 QCNCETNWGGLLCDKDLNYCGSHH-------PCTNGGTCINAEPDQYRCTCPDGYSGRNC 344
+C C + G+ C+ +L GSH PC NGGTC + + C CP G++G C
Sbjct: 203 ECLCAPGYTGVYCE-ELCPPGSHGAHCELRCPCQNGGTCHHITGE---CACPPGWTGAVC 258
Query: 345 EK-------AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDID------ECAS 391
+ ++ PC +GG C V +CHC +G+ G C + +C+
Sbjct: 259 AQPCPPGTFGQNCSQDCPCHHGGQCDHVTG--QCHCTAGYMGDRCQEECPFGSFGFQCSQ 316
Query: 392 N-PCAAGGTCVDQVDGFEC------------ICPEQWVGATCQL----------DVNDCR 428
+ C GG C EC +CPE G C L +
Sbjct: 317 HCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVT 376
Query: 429 GQCQHGGTCKDLVNGYQC--VCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 486
G C TC+ +G+ C CP G+ G C+L C +G C + G C C
Sbjct: 377 GAC----TCQPGWSGHHCNESCPVGYYGDGCQLP------CTCQNGADCHSITGG--CTC 424
Query: 487 PQGFSGPLCEVDVDLCEPSP-------CRNGARCYNLEGDYYCACPDDFGGKNCSVP--- 536
GF G +C V P C NG C ++G C C + + G +C++P
Sbjct: 425 APGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGS--CTCKEGWQGLDCTLPCPS 482
Query: 537 -------REPCP---GGACRVIDG-CGSDAG--------PGMPGTAASGVCGPHGRCVSQ 577
E C G AC IDG C G P GT C H C
Sbjct: 483 GTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLN-CSEHCDCSHA 541
Query: 578 PGGN---FSCICDSGFTGTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCPSG 627
G + C C +G+TG C P C NGG+C E + C C G
Sbjct: 542 DGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGS--CECAPG 599
Query: 628 WEGELCDTNPNDCLP--------DPC----HSRGRCYDLVNDFYCACDDGWKGKTCHS-- 673
+ G LC C P PC HS C+ + C C G+ G C+
Sbjct: 600 FRGPLCQ---RICPPGFYGHGCAQPCPLCVHSSRPCHHISG--ICECLPGFSGALCNQVC 654
Query: 674 -----REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN-------- 720
+ +C+N GTC + C C PGW G C+ A C P
Sbjct: 655 AGGYFGQDCAQLCSCANNGTCSPIDGS--CQCFPGWIGKDCSQA----CPPGFWGPACFH 708
Query: 721 --PCVNGGTCVGSGASFSCICRDGWEGRTCTHNT------NDCNPL-PCYNGGICVDGVN 771
C NG +C S +C C GW G CT DC + C NG C D ++
Sbjct: 709 ACSCHNGASC--SAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASC-DHIS 765
Query: 772 WFRCECAPGFAGPDCRINIDE------CQS-SPCAYGATCVDEINGYRCSCPPGRAGPRC 824
+C C GF G C CQ C +TC D + G C C PG G RC
Sbjct: 766 G-KCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTC-DHVTG-TCYCSPGFKGIRC 822
Query: 825 QE 826
+
Sbjct: 823 DQ 824
Score = 159 bits (401), Expect = 2e-38
Identities = 160/581 (27%), Positives = 207/581 (35%), Gaps = 163/581 (28%)
Query: 182 HFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQY-------------GN 228
H G H+ Q C Y C + C P F + C Q+ G
Sbjct: 278 HHGGQCDHVTGQCH--CTAGYMGDRCQEEC-PFGSF--GFQCSQHCDCHNGGQCSPTTGA 332
Query: 229 KACMDGWMGKECKEAVCKQGCNLLHG-GCTVP---------------GECRCSYGWQGRF 272
C G+ G C+E +C +G LHG GCT+P G C C GW G
Sbjct: 333 CECEPGYKGPRCQERLCPEG---LHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHH 389
Query: 273 CDECVPYPGCVHGSCVEPWQC----NCETNWGGLLCDKDLN---------------YCGS 313
C+E P G C P C +C + GG C C S
Sbjct: 390 CNESCPV-GYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSS 448
Query: 314 HHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE----------KAEHACTSNPCANGGSCH 363
C NGGTC P CTC +G+ G +C +CT CANG +C
Sbjct: 449 ICSCNNGGTC---SPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCT---CANGAACS 502
Query: 364 EVPSGFECHCPSGWSGPTCALDIDE------CASN-PCAAGGTCVDQVDGFECICPEQWV 416
+ C C GW G TC L + C+ + C+ C D V G C C W
Sbjct: 503 PIDGS--CSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGC-DPVTG-HCCCLAGWT 558
Query: 417 GATCQLDVNDCRG--------QCQHGGTCKDLVNGYQC-----------VCPRGFGGRHC 457
G C R C++GG+C +C +CP GF G C
Sbjct: 559 GIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGC 618
Query: 458 ELERDEC--ASSPCHS-GGLCEDLADGFHCHCPQGFSGPLCE-------VDVDLCEPSPC 507
C +S PCH G+CE C GFSG LC D + C
Sbjct: 619 AQPCPLCVHSSRPCHHISGICE---------CLPGFSGALCNQVCAGGYFGQDCAQLCSC 669
Query: 508 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGG--------ACRVIDG--CGSDAG- 556
N C ++G C C + GK+CS + CP G AC +G C ++ G
Sbjct: 670 ANNGTCSPIDGS--CQCFPGWIGKDCS---QACPPGFWGPACFHACSCHNGASCSAEDGA 724
Query: 557 ----PGMPGTAASGVCGPH------GR-CVSQPGGNFS-----CICDSGFTGTYCHEN-I 599
PG G + C GR C Q G + C C +GFTG +C +
Sbjct: 725 CHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCA 784
Query: 600 DDCLGQPCR------NGGTCIDEVDAFRCFCPSGWEGELCD 634
G C+ N TC D V C+C G++G CD
Sbjct: 785 PGTFGYGCQQLCECMNNSTC-DHVTG-TCYCSPGFKGIRCD 823
Score = 63.5 bits (153), Expect = 1e-09
Identities = 47/179 (26%), Positives = 70/179 (39%), Gaps = 36/179 (20%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEA--------VCKQG 248
C Y+ C + C N+ TC G+ C GW+GK+C +A C
Sbjct: 654 CAGGYFGQDCAQLCSCANNG----TCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHA 709
Query: 249 CNLLHGG-CTVP-GECRCSYGWQGRFCDECVPYP----------GCVHGSCVE--PWQCN 294
C+ +G C+ G C C+ GW G FC + P C +G+ + +C
Sbjct: 710 CSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCT 769
Query: 295 CETNWGGLLCDK-----DLNY-CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA 347
C T + G C++ Y C C N TC + C C G+ G C++A
Sbjct: 770 CRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGT---CYCSPGFKGIRCDQA 825
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 214 bits (545), Expect = 4e-55
Identities = 153/507 (30%), Positives = 209/507 (41%), Gaps = 83/507 (16%)
Query: 14 LLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRV 73
++L +++ RP G FELQ+ + G + C C + RV
Sbjct: 14 VILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSA-----------RLPCRLFFRV 62
Query: 74 CLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIP 133
CLK ++ PC+ G A G + P A D GL+ +P
Sbjct: 63 CLKPGLSEEAAESPCALG--AALSARGPVYTEQPGAPAPDLPLP---------DGLLQVP 111
Query: 134 FQFAWPRSFTLIVEAWDWDNDTTPNEEL----------LIERVSHAGMINPEDRWKSLHF 183
F+ AWP +F+ I+E W EEL L+ RV+ + W
Sbjct: 112 FRDAWPGTFSFIIETW--------REELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQ 163
Query: 184 SGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 243
L R RC+ C + CRPR+ C G + C + EC+
Sbjct: 164 RAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAP 217
Query: 244 -VCKQGCNLLHGGCTVPGECRCSYGWQGRFC------DEC--------------VPYPG- 281
VC+ GC+ HG C PGECRC GW G C C VP PG
Sbjct: 218 LVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
Query: 282 -----CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCIN-AEPDQ- 330
C +G SC E ++C C + GL C+ C PC NGG C+ A+PD
Sbjct: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPDSA 336
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
Y C CP G+ G NCEK C+ PC NGG C ++ C C +G++GP C D+D+CA
Sbjct: 337 YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA 396
Query: 391 SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCP 449
CA GGTCV+ C C + G C+ + C + C HGG C +G C C
Sbjct: 397 GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACA 456
Query: 450 RGFGGRHCE--LERDECASSPCHSGGL 474
G+ G CE + D ++ P GL
Sbjct: 457 PGYMGARCEFPVHPDGASALPAAPPGL 483
Score = 173 bits (439), Expect = 8e-43
Identities = 103/307 (33%), Positives = 128/307 (41%), Gaps = 42/307 (13%)
Query: 539 PCPGGACRVI---DGCGSDAGPGM------------PGTAASGVCGPHGRCVSQPGGNFS 583
P G AC + S GPG+ P +G HG C QPG
Sbjct: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG---E 236
Query: 584 CICDSGFTGTYCHENID--DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
C C G+TG C + CL + T C P P C
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-------GCLVPG----------PGPCD 279
Query: 642 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD---TFRC 698
+PC + G C + F C C G+ G C C C NGG C D + C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 758
CPPG++GS C + C PC NGG C+ G + C CR G+ G C H+ +DC
Sbjct: 340 HCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 759 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 818
C NGG CV+G RC CA GF G DCR D C + PCA+G C +G C+C PG
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 819 RAGPRCQ 825
G RC+
Sbjct: 459 YMGARCE 465
Score = 160 bits (404), Expect = 9e-39
Identities = 92/286 (32%), Positives = 116/286 (40%), Gaps = 58/286 (20%)
Query: 342 RNCEKAEHACTSNPCANGGSCHEVPSGF-----ECHCPSGWSGPTCALDIDE-------- 388
R C E C + G E GF EC C GW+GP C + +
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPE--HGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRG 262
Query: 389 ---------------CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQ 432
C NPCA GG+C + FEC CP + G C++ C G C
Sbjct: 263 PSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCF 322
Query: 433 HGGTC---KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 489
+GG C D + Y C CP GF G +CE D C+ PC +GGLC DL C C G
Sbjct: 323 NGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAG 382
Query: 490 FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVID 549
F+GP CE D+D C C NG C G + C+C FGG++C +PC
Sbjct: 383 FAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPC--------- 433
Query: 550 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 595
A+ C GRC + G C C G+ G C
Sbjct: 434 --------------AARPCAHGGRCYAHFSG-LVCACAPGYMGARC 464
Score = 146 bits (368), Expect = 1e-34
Identities = 83/245 (33%), Positives = 110/245 (44%), Gaps = 30/245 (12%)
Query: 622 CFCPSGWEGELCDT--NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 679
C C GW G LC + + CL S LV CD
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------PGPCD 279
Query: 680 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG---ASFS 736
C+NGG+C ++ +F C CP G+ G C V+ +C PC NGG CVG +++
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVS-GVTCADGPCFNGGLCVGGADPDSAYI 338
Query: 737 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 796
C C G++G C + C+ PC NGG+C+D + RC C GFAGP C ++D+C
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 797 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSC 854
CA G TCV+ +RCSC G G C+E R C G + H S V C
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV-----C 453
Query: 855 RCLDG 859
C G
Sbjct: 454 ACAPG 458
Score = 122 bits (307), Expect = 2e-27
Identities = 85/278 (30%), Positives = 109/278 (39%), Gaps = 69/278 (24%)
Query: 669 KTCHSREFQCDA-YTCSNG-----GTCYDSGDTFRCACPPGWKGSTCAV-AKNSSCLP-- 719
+ C E +C+A C G G C G+ C C GW G C V SSCL
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPR 261
Query: 720 -------------------NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760
NPC NGG+C + SF C C G+ G C + C PC
Sbjct: 262 GPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
Query: 761 YNGGICVDGVN---WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 817
+NGG+CV G + + C C PGF G +C +D C PC G C+D + RC C
Sbjct: 322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRA 381
Query: 818 GRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLL 875
G AGPRC+ + GR+C + GT G + + C C G
Sbjct: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGA-----HRCSCALGFG-------------- 422
Query: 876 AGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 913
G+ C E+A C PC G C A
Sbjct: 423 -------------GRDCRERAD-PCAARPCAHGGRCYA 446
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 23/147 (15%)
Query: 799 AYGATCVDEINGYRCS------CPPGRAGPRCQEVIGFGRSCWS-----RGTPFPHGSSW 847
+Y A C G C+ P R GP + C + G HG +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG--F 230
Query: 848 VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR--CLEKAPGQCLRPPC 905
E CRCL+G W G + LS + P CL PG C PC
Sbjct: 231 CEQPGECRCLEG-------WTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
Query: 906 EAWGECGAEEPPSTPCLPRSGHLDNNC 932
G C +E P S C G C
Sbjct: 284 ANGGSC-SETPRSFECTCPRGFYGLRC 309
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 214 bits (545), Expect = 4e-55
Identities = 153/507 (30%), Positives = 209/507 (41%), Gaps = 83/507 (16%)
Query: 14 LLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRV 73
++L +++ RP G FELQ+ + G + C C + RV
Sbjct: 14 VILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSA-----------RLPCRLFFRV 62
Query: 74 CLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIP 133
CLK ++ PC+ G A G + P A D GL+ +P
Sbjct: 63 CLKPGLSEEAAESPCALG--AALSARGPVYTEQPGAPAPDLPLP---------DGLLQVP 111
Query: 134 FQFAWPRSFTLIVEAWDWDNDTTPNEEL----------LIERVSHAGMINPEDRWKSLHF 183
F+ AWP +F+ I+E W EEL L+ RV+ + W
Sbjct: 112 FRDAWPGTFSFIIETW--------REELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQ 163
Query: 184 SGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 243
L R RC+ C + CRPR+ C G + C + EC+
Sbjct: 164 RAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAP 217
Query: 244 -VCKQGCNLLHGGCTVPGECRCSYGWQGRFC------DEC--------------VPYPG- 281
VC+ GC+ HG C PGECRC GW G C C VP PG
Sbjct: 218 LVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
Query: 282 -----CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCIN-AEPDQ- 330
C +G SC E ++C C + GL C+ C PC NGG C+ A+PD
Sbjct: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPDSA 336
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
Y C CP G+ G NCEK C+ PC NGG C ++ C C +G++GP C D+D+CA
Sbjct: 337 YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA 396
Query: 391 SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQ-CQHGGTCKDLVNGYQCVCP 449
CA GGTCV+ C C + G C+ + C + C HGG C +G C C
Sbjct: 397 GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACA 456
Query: 450 RGFGGRHCE--LERDECASSPCHSGGL 474
G+ G CE + D ++ P GL
Sbjct: 457 PGYMGARCEFPVHPDGASALPAAPPGL 483
Score = 173 bits (439), Expect = 8e-43
Identities = 103/307 (33%), Positives = 128/307 (41%), Gaps = 42/307 (13%)
Query: 539 PCPGGACRVI---DGCGSDAGPGM------------PGTAASGVCGPHGRCVSQPGGNFS 583
P G AC + S GPG+ P +G HG C QPG
Sbjct: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG---E 236
Query: 584 CICDSGFTGTYCHENID--DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
C C G+TG C + CL + T C P P C
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-------GCLVPG----------PGPCD 279
Query: 642 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD---TFRC 698
+PC + G C + F C C G+ G C C C NGG C D + C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 758
CPPG++GS C + C PC NGG C+ G + C CR G+ G C H+ +DC
Sbjct: 340 HCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 759 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 818
C NGG CV+G RC CA GF G DCR D C + PCA+G C +G C+C PG
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 819 RAGPRCQ 825
G RC+
Sbjct: 459 YMGARCE 465
Score = 160 bits (404), Expect = 9e-39
Identities = 92/286 (32%), Positives = 116/286 (40%), Gaps = 58/286 (20%)
Query: 342 RNCEKAEHACTSNPCANGGSCHEVPSGF-----ECHCPSGWSGPTCALDIDE-------- 388
R C E C + G E GF EC C GW+GP C + +
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPE--HGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRG 262
Query: 389 ---------------CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCR-GQCQ 432
C NPCA GG+C + FEC CP + G C++ C G C
Sbjct: 263 PSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCF 322
Query: 433 HGGTC---KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 489
+GG C D + Y C CP GF G +CE D C+ PC +GGLC DL C C G
Sbjct: 323 NGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAG 382
Query: 490 FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVID 549
F+GP CE D+D C C NG C G + C+C FGG++C +PC
Sbjct: 383 FAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPC--------- 433
Query: 550 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 595
A+ C GRC + G C C G+ G C
Sbjct: 434 --------------AARPCAHGGRCYAHFSG-LVCACAPGYMGARC 464
Score = 146 bits (368), Expect = 1e-34
Identities = 83/245 (33%), Positives = 110/245 (44%), Gaps = 30/245 (12%)
Query: 622 CFCPSGWEGELCDT--NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 679
C C GW G LC + + CL S LV CD
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------PGPCD 279
Query: 680 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG---ASFS 736
C+NGG+C ++ +F C CP G+ G C V+ +C PC NGG CVG +++
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVS-GVTCADGPCFNGGLCVGGADPDSAYI 338
Query: 737 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 796
C C G++G C + C+ PC NGG+C+D + RC C GFAGP C ++D+C
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 797 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSC 854
CA G TCV+ +RCSC G G C+E R C G + H S V C
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV-----C 453
Query: 855 RCLDG 859
C G
Sbjct: 454 ACAPG 458
Score = 122 bits (307), Expect = 2e-27
Identities = 85/278 (30%), Positives = 109/278 (39%), Gaps = 69/278 (24%)
Query: 669 KTCHSREFQCDA-YTCSNG-----GTCYDSGDTFRCACPPGWKGSTCAV-AKNSSCLP-- 719
+ C E +C+A C G G C G+ C C GW G C V SSCL
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPR 261
Query: 720 -------------------NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760
NPC NGG+C + SF C C G+ G C + C PC
Sbjct: 262 GPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
Query: 761 YNGGICVDGVN---WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 817
+NGG+CV G + + C C PGF G +C +D C PC G C+D + RC C
Sbjct: 322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRA 381
Query: 818 GRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLL 875
G AGPRC+ + GR+C + GT G + + C C G
Sbjct: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGA-----HRCSCALGFG-------------- 422
Query: 876 AGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 913
G+ C E+A C PC G C A
Sbjct: 423 -------------GRDCRERAD-PCAARPCAHGGRCYA 446
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 23/147 (15%)
Query: 799 AYGATCVDEINGYRCS------CPPGRAGPRCQEVIGFGRSCWS-----RGTPFPHGSSW 847
+Y A C G C+ P R GP + C + G HG +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG--F 230
Query: 848 VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR--CLEKAPGQCLRPPC 905
E CRCL+G W G + LS + P CL PG C PC
Sbjct: 231 CEQPGECRCLEG-------WTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
Query: 906 EAWGECGAEEPPSTPCLPRSGHLDNNC 932
G C +E P S C G C
Sbjct: 284 ANGGSC-SETPRSFECTCPRGFYGLRC 309
>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
Length = 4242
Score = 212 bits (540), Expect = 1e-54
Identities = 212/734 (28%), Positives = 274/734 (37%), Gaps = 169/734 (23%)
Query: 262 CRCSYGWQGRFC---------------------DECVPYPGCVHGSCVEPWQCNCETNWG 300
C C GW G C D+C CV G CV C +
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCV------CFPGYT 209
Query: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
G C + C G C+ Q C C G+SG +C ++ +C C+ G
Sbjct: 210 GPSC----GWPSCPGDCQGRGRCV-----QGVCVCRAGFSGPDC--SQRSCPRG-CSQRG 257
Query: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
C G C C G++G D+C C G + + + C+C + G C
Sbjct: 258 RC----EGGRCVCDPGYTG-------DDCGMRSCPRGCSQRGRCENGRCVCNPGYTGEDC 306
Query: 421 QLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP--CHSGGLCEDL 478
V C C G CKD +CVC G+ G C S P C GG C D
Sbjct: 307 --GVRSCPRGCSQRGRCKD----GRCVCDPGYTGEDCGTR-----SCPWDCGEGGRCVD- 354
Query: 479 ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE 538
C C G++G C C P CR RC + E C C + G +C V
Sbjct: 355 ---GRCVCWPGYTGEDCSTRT--C-PRDCRGRGRCEDGE----CICDTGYSGDDCGV--R 402
Query: 539 PCPGGACRVIDGCGSD---AGPGMPGT-----AASGVCGPHGRCVSQPGGNFSCICDSGF 590
CPG C C PG GT A C GRC N C+C++G+
Sbjct: 403 SCPGD-CNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRC-----ENGVCVCNAGY 456
Query: 591 TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGR 650
+G C + C G CR G C ++ RC C G+ G C T P C RGR
Sbjct: 457 SGEDC--GVRSCPGD-CRGRGRC----ESGRCMCWPGYTGRDCGTR---ACPGDCRGRGR 506
Query: 651 CYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 710
C D C C+ G+ G+ C SR D C G C D C C G+ G C+
Sbjct: 507 CV----DGRCVCNPGFTGEDCGSRRCPGD---CRGHGLCEDG----VCVCDAGYSGEDCS 555
Query: 711 VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGV 770
SC P C G C+ C+C DG+ G C C P C G+C DGV
Sbjct: 556 ---TRSC-PGGCRGRGQCLDG----RCVCEDGYSGEDC--GVRQC-PNDCSQHGVCQDGV 604
Query: 771 NWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGF 830
C C G+ DC +I C S+ C C + RC C PG GP C +
Sbjct: 605 ----CICWEGYVSEDC--SIRTCPSN-CHGRGRCEEG----RCLCDPGYTGPTCATRM-C 652
Query: 831 GRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP--L 888
C RG RC+ G C V G + C GQ E ++ CP
Sbjct: 653 PADCRGRG----------------RCVQGVCLC-HVGYGGEDC---GQEEPPASACPGGC 692
Query: 889 GQRCLEKAPGQCL------RPPCEAW---GEC-GAEEPPSTPCLPRSGHLDNNCAR--LT 936
G R L +A GQC+ P C G+C G E C+ + G+ +C T
Sbjct: 693 GPRELCRA-GQCVCVEGFRGPDCAIQTCPGDCRGRGECHDGSCVCKDGYAGEDCGEEVPT 751
Query: 937 LHFNRDHVPQGTTV 950
+ R H+ + TTV
Sbjct: 752 IEGMRMHLLEETTV 765
Score = 209 bits (531), Expect = 2e-53
Identities = 193/680 (28%), Positives = 250/680 (36%), Gaps = 138/680 (20%)
Query: 227 GNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGS 286
G C G+ G C C C G C V G C C G+ G C + GC
Sbjct: 200 GRCVCFPGYTGPSCGWPSCPGDCQG-RGRC-VQGVCVCRAGFSGPDCSQRSCPRGCSQRG 257
Query: 287 CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
E +C C+ + G D C+ G C N RC C GY+G +C
Sbjct: 258 RCEGGRCVCDPGYTG----DDCGMRSCPRGCSQRGRCENG-----RCVCNPGYTGEDC-- 306
Query: 347 AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG 406
+C C+ G C + C C G++G C C + C GG CVD
Sbjct: 307 GVRSCPRG-CSQRGRCKDG----RCVCDPGYTGEDCGTR--SCPWD-CGEGGRCVDG--- 355
Query: 407 FECICPEQWVGATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 466
C+C + G C C C+ G C+D +C+C G+ G C +
Sbjct: 356 -RCVCWPGYTGEDCS--TRTCPRDCRGRGRCED----GECICDTGYSGDDCGVRS---CP 405
Query: 467 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 526
C+ G CED C C G++G C C P CR RC N C C
Sbjct: 406 GDCNQRGRCED----GRCVCWPGYTGTDCGSRA--C-PRDCRGRGRCEN----GVCVCNA 454
Query: 527 DFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 586
+ G++C V CPG C GRC S C+C
Sbjct: 455 GYSGEDCGV--RSCPGD------------------------CRGRGRCESG-----RCMC 483
Query: 587 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCH 646
G+TG C C G CR G C+D RC C G+ GE C + P C
Sbjct: 484 WPGYTGRDCGTRA--CPGD-CRGRGRCVDG----RCVCNPGFTGEDCGSRR---CPGDCR 533
Query: 647 SRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKG 706
G C D V C CD G+ G+ C +R C C G C D RC C G+ G
Sbjct: 534 GHGLCEDGV----CVCDAGYSGEDCSTR--SCPG-GCRGRGQCLDG----RCVCEDGYSG 582
Query: 707 STCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC 766
C V + PN C G C CIC +G+ C+ T C P C+ G C
Sbjct: 583 EDCGVRQ----CPNDCSQHGVCQDG----VCICWEGYVSEDCSIRT--C-PSNCHGRGRC 631
Query: 767 VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQE 826
+G RC C PG+ GP C + C + C CV + C C G G C +
Sbjct: 632 EEG----RCLCDPGYTGPTCATRM--CPAD-CRGRGRCVQGV----CLCHVGYGGEDCGQ 680
Query: 827 VIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLDGRR--DCSKVWCGWKPCLLAGQPEAL 882
+C P G E C + C C++G R DC+ C P G+ E
Sbjct: 681 EEPPASAC-------PGGCGPRELCRAGQCVCVEGFRGPDCAIQTC---PGDCRGRGECH 730
Query: 883 SAQCP-----LGQRCLEKAP 897
C G+ C E+ P
Sbjct: 731 DGSCVCKDGYAGEDCGEEVP 750
Score = 184 bits (467), Expect = 4e-46
Identities = 173/609 (28%), Positives = 225/609 (36%), Gaps = 143/609 (23%)
Query: 195 RVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNK-----ACMDGWMGKECKEAVCKQGC 249
R CD Y C PR C Q G C G+ G++C C +GC
Sbjct: 263 RCVCDPGYTGDDCGMRSCPRG-------CSQRGRCENGRCVCNPGYTGEDCGVRSCPRGC 315
Query: 250 NLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLN 309
+ G C G C C G+ G C G+ PW C
Sbjct: 316 S-QRGRCK-DGRCVCDPGYTGEDC-----------GTRSCPWDCG--------------- 347
Query: 310 YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGF 369
GG C++ RC C GY+G +C + C + C G C +
Sbjct: 348 ---------EGGRCVDG-----RCVCWPGYTGEDC--STRTCPRD-CRGRGRCED----G 386
Query: 370 ECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC--QLDVNDC 427
EC C +G+SG C + C + C G C D C+C + G C + DC
Sbjct: 387 ECICDTGYSGDDCG--VRSCPGD-CNQRGRCEDG----RCVCWPGYTGTDCGSRACPRDC 439
Query: 428 RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCP 487
RG+ G C++ V CVC G+ G C + C G CE C C
Sbjct: 440 RGR----GRCENGV----CVCNAGYSGEDCGV---RSCPGDCRGRGRCE----SGRCMCW 484
Query: 488 QGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPG----- 542
G++G C C P CR RC D C C F G++C R CPG
Sbjct: 485 PGYTGRDC--GTRAC-PGDCRGRGRCV----DGRCVCNPGFTGEDCGSRR--CPGDCRGH 535
Query: 543 GACRVIDG-CGSDA---GPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN 598
G C DG C DA G + G C G+C+ + C+C+ G++G C
Sbjct: 536 GLCE--DGVCVCDAGYSGEDCSTRSCPGGCRGRGQCL-----DGRCVCEDGYSGEDC--G 586
Query: 599 IDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDF 658
+ C C G C D V C C WEG + + P CH RGRC +
Sbjct: 587 VRQC-PNDCSQHGVCQDGV----CIC---WEGYVSEDCSIRTCPSNCHGRGRC----EEG 634
Query: 659 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAK-NSSC 717
C CD G+ G TC +R D C G C C C G+ G C + +S
Sbjct: 635 RCLCDPGYTGPTCATRMCPAD---CRGRGRCVQG----VCLCHVGYGGEDCGQEEPPASA 687
Query: 718 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCEC 777
P C C + C+C +G+ G C T C P C G C DG C C
Sbjct: 688 CPGGCGPRELC----RAGQCVCVEGFRGPDCAIQT--C-PGDCRGRGECHDG----SCVC 736
Query: 778 APGFAGPDC 786
G+AG DC
Sbjct: 737 KDGYAGEDC 745
Score = 57.8 bits (138), Expect = 6e-08
Identities = 59/210 (28%), Positives = 73/210 (34%), Gaps = 51/210 (24%)
Query: 736 SCICRDGWEGRTCTHNTN-------------DCNPLPCYNGGICVDGVNWFRCECAPGFA 782
+C C GW G TC+ T+ C P C + G CV G RC C PG+
Sbjct: 155 TCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSC-PDDCNDQGRCVRG----RCVCFPGYT 209
Query: 783 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFP 842
GP C C C CV + C C G +GP C + RSC P
Sbjct: 210 GPSC--GWPSCPGD-CQGRGRCVQGV----CVCRAGFSGPDCSQ-----RSC-------P 250
Query: 843 HGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLR 902
G S C RC+ C + G C + P C RC G+C+
Sbjct: 251 RGCSQRGRCEGGRCV-----CDPGYTG-DDCGMRSCPRG----CSQRGRC---ENGRCVC 297
Query: 903 PPCEAWGECGAEEPPSTPCLPRSGHLDNNC 932
P +CG P C R D C
Sbjct: 298 NPGYTGEDCGVRSCP-RGCSQRGRCKDGRC 326
Score = 36.6 bits (83), Expect = 0.15
Identities = 36/139 (25%), Positives = 51/139 (36%), Gaps = 31/139 (22%)
Query: 805 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN-SCRCLDGRRDC 863
V +++ CSC PG GP C + + +P S +DCN RC+ GR C
Sbjct: 148 VFDLSRCTCSCEPGWGGPTCSDPTD---AEIPPSSPPSASGSCPDDCNDQGRCVRGRCVC 204
Query: 864 SKVW----CGWKPC----------------LLAG--QPEALSAQCPLGQRCLEKA---PG 898
+ CGW C AG P+ CP G C ++ G
Sbjct: 205 FPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRG--CSQRGRCEGG 262
Query: 899 QCLRPPCEAWGECGAEEPP 917
+C+ P +CG P
Sbjct: 263 RCVCDPGYTGDDCGMRSCP 281
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 209 bits (533), Expect = 1e-53
Identities = 104/303 (34%), Positives = 140/303 (46%), Gaps = 30/303 (9%)
Query: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP-------------WQCNCETNWGGLL 303
T P C CS W + PG S EP +QC + +
Sbjct: 856 TNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVD---IN 912
Query: 304 CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCH 363
N C S PC N GTC + YRC CP Y G++C + C NPC +GG+CH
Sbjct: 913 IVAKCNACLSS-PCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCH 971
Query: 364 EVPS---GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
S GF C CP G+ G C ++ D+C N C TCVD ++ + CICP + G C
Sbjct: 972 LSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELC 1031
Query: 421 QLDVNDCRGQ---CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCED 477
++ C + CQH C L G+ C C G+ G+ CE + D+C + C G C D
Sbjct: 1032 DEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVD 1091
Query: 478 LADGFHCHCPQGFSGPLCE-------VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGG 530
+G+ C CPQGFSGP CE + C+ C+NGA+C ++ + C CP F G
Sbjct: 1092 TINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAG 1151
Query: 531 KNC 533
C
Sbjct: 1152 PRC 1154
Score = 176 bits (445), Expect = 2e-43
Identities = 85/240 (35%), Positives = 119/240 (49%), Gaps = 14/240 (5%)
Query: 602 CLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY--DLVND- 657
CL PC+N GTC D V+ +RC CP ++G+ C N C+ +PC G C+ D D
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDG 979
Query: 658 FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC 717
F C+C G++G+ C C+ C N TC D + + C CPP + G C + C
Sbjct: 980 FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDH-C 1038
Query: 718 LP--NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 775
+P N C + C+ FSC C G+ G+ C + +DC C +G CVD +N + C
Sbjct: 1039 VPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
Query: 776 ECAPGFAGPDCR-------INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 828
C GF+GP C + C C GA C+ C CPPG AGPRC+++I
Sbjct: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLI 1158
Score = 162 bits (410), Expect = 2e-39
Identities = 85/259 (32%), Positives = 117/259 (45%), Gaps = 16/259 (6%)
Query: 290 PWQCNCETNWGGLLC-----DKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNC 344
P C+C W + + C S P + + +++C P N
Sbjct: 858 PLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADR-LLLTTPTHRFQCKGPVDI---NI 913
Query: 345 EKAEHACTSNPCANGGSCHEVPSG-FECHCPSGWSGPTCALDIDECASNPCAAGGTCV-- 401
+AC S+PC N G+C + P + C CP + G C + I+ C NPC GGTC
Sbjct: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
Query: 402 -DQVDGFECICPEQWVGATCQLDVNDCR-GQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL 459
DGF C CP + G C+++ +DC C++ TC D +N Y C+CP + G C+
Sbjct: 974 DSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDE 1033
Query: 460 ERDECAS--SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE 517
D C + C C L GF C C G+SG LCE D D C CR+GA+C +
Sbjct: 1034 VIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTI 1093
Query: 518 GDYYCACPDDFGGKNCSVP 536
Y C CP F G C P
Sbjct: 1094 NGYTCTCPQGFSGPFCEHP 1112
Score = 161 bits (407), Expect = 4e-39
Identities = 79/252 (31%), Positives = 118/252 (46%), Gaps = 33/252 (13%)
Query: 431 CQHGGTC-KDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC---EDLADGFHCHC 486
C++ GTC +D V Y+C CP + G+ C + + C +PC GG C + DGF C C
Sbjct: 925 CKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSC 984
Query: 487 PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACR 546
P GF G CE++ D CE + C N A C + +Y C CP ++ G+ C
Sbjct: 985 PLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCD-----------E 1033
Query: 547 VIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP 606
VID C + +C +C+ G FSC C G++G C + DDC+
Sbjct: 1034 VIDHCVPEL----------NLCQHEAKCIPLDKG-FSCECVPGYSGKLCETDNDDCVAHK 1082
Query: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNP-------NDCLPDPCHSRGRCYDLVNDFY 659
CR+G C+D ++ + C CP G+ G C+ P + C C + +C + +
Sbjct: 1083 CRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT 1142
Query: 660 CACDDGWKGKTC 671
C C G+ G C
Sbjct: 1143 CRCPPGFAGPRC 1154
Score = 152 bits (385), Expect = 1e-36
Identities = 84/262 (32%), Positives = 113/262 (43%), Gaps = 42/262 (16%)
Query: 502 CEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVP-----REPCP-GGACRVIDGCGSD 554
C SPC+N C + Y CACP + GK+C+VP + PC GG C + D
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSD----- 974
Query: 555 AGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI 614
S G FSC C GF G C N DDC C N TC+
Sbjct: 975 ---------------------SHKDG-FSCSCPLGFEGQRCEINPDDCEDNDCENNATCV 1012
Query: 615 DEVDAFRCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCH 672
D ++ + C CP + GELCD + C+P+ C +C L F C C G+ GK C
Sbjct: 1013 DGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1072
Query: 673 SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC------AVAKNSSCLPNPCVNGG 726
+ C A+ C +G C D+ + + C CP G+ G C + + S C C NG
Sbjct: 1073 TDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGA 1132
Query: 727 TCVGSGASFSCICRDGWEGRTC 748
C+ +C C G+ G C
Sbjct: 1133 QCIVVQQEPTCRCPPGFAGPRC 1154
Score = 149 bits (375), Expect = 2e-35
Identities = 74/194 (38%), Positives = 99/194 (51%), Gaps = 7/194 (3%)
Query: 638 NDCLPDPCHSRGRC-YDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG--- 693
N CL PC + G C D V + CAC +KGK C C C +GGTC+ S
Sbjct: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHK 977
Query: 694 DTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTN 753
D F C+CP G++G C + + C N C N TCV ++ CIC + G C +
Sbjct: 978 DGFSCSCPLGFEGQRCEINPDD-CEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036
Query: 754 DCNPLP--CYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 811
C P C + C+ F CEC PG++G C + D+C + C +GA CVD INGY
Sbjct: 1037 HCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGY 1096
Query: 812 RCSCPPGRAGPRCQ 825
C+CP G +GP C+
Sbjct: 1097 TCTCPQGFSGPFCE 1110
Score = 108 bits (270), Expect = 3e-23
Identities = 54/125 (43%), Positives = 65/125 (52%), Gaps = 10/125 (8%)
Query: 711 VAKNSSCLPNPCVNGGTCVGSGAS-FSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC--- 766
VAK ++CL +PC N GTC + C C ++G+ CT N C PC +GG C
Sbjct: 914 VAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLS 973
Query: 767 ---VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPR 823
DG F C C GF G C IN D+C+ + C ATCVD IN Y C CPP G
Sbjct: 974 DSHKDG---FSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGEL 1030
Query: 824 CQEVI 828
C EVI
Sbjct: 1031 CDEVI 1035
Score = 73.6 bits (179), Expect = 1e-12
Identities = 39/125 (31%), Positives = 56/125 (44%), Gaps = 11/125 (8%)
Query: 678 CDAYTCSNGGTCYD-SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFS 736
C + T G C D+ C C PGW G C CL + C + G CV +G S+
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
Query: 737 CICRDGWEGRTCTH---NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDEC 793
C C +G+ G C + + N C+ C++G + C C PGF+G C+
Sbjct: 1391 CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------ 1444
Query: 794 QSSPC 798
Q +PC
Sbjct: 1445 QENPC 1449
Score = 67.8 bits (164), Expect = 6e-11
Identities = 40/123 (32%), Positives = 56/123 (45%), Gaps = 16/123 (13%)
Query: 607 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPND-CLPDPCHSRGRCYDLVNDFYCACDDG 665
C++G E D+ C C GW G LCD D CL CH G+C + C C +G
Sbjct: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH-HGKCVATGTSYMCKCAEG 1396
Query: 666 WKGKTCHSREFQ---CDAYTCSNGGTCY--DSGDTFRCACPPGWKGSTCAVAKNSSCLPN 720
+ G C ++ C A+ C + G C+ D G+ + C C PG+ G C N
Sbjct: 1397 YGGDLCDNKNDSANACSAFKCHH-GQCHISDQGEPY-CLCQPGFSGEHCQ-------QEN 1447
Query: 721 PCV 723
PC+
Sbjct: 1448 PCL 1450
Score = 65.9 bits (159), Expect = 2e-10
Identities = 46/150 (30%), Positives = 64/150 (42%), Gaps = 13/150 (8%)
Query: 431 CQHGGTCKDLV-NGYQCVCPRGFGGRHCELE-RDECASSPCHSGGLCEDLADGFHCHCPQ 488
C+HG C+ + + C C G+ G C+ E RD C CH G C + C C +
Sbjct: 1338 CKHG-LCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAE 1395
Query: 489 GFSGPLCEVDVD---LCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGAC 545
G+ G LC+ D C C +G + +G+ YC C F G++C PC G
Sbjct: 1396 GYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ-QENPCLGQVV 1454
Query: 546 RVI----DGCGSDA-GPGMPGTAASGVCGP 570
R + G S A +P G CGP
Sbjct: 1455 REVIRRQKGYASCATASKVPIMECRGGCGP 1484
Score = 63.2 bits (152), Expect = 1e-09
Identities = 60/203 (29%), Positives = 79/203 (38%), Gaps = 46/203 (22%)
Query: 240 CKEA-VCKQG-CNLLHGGCTVPGECRCSYGWQGRFCDECVPYP----GCVHGSCV---EP 290
CK VCK G C + V C C GW G CD+ P C HG CV
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVV---CECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTS 1388
Query: 291 WQCNCETNWGGLLCDK---DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA 347
+ C C +GG LCD N C S C +G I+ + + Y C C G+SG +C++
Sbjct: 1389 YMCKCAEGYGGDLCDNKNDSANAC-SAFKCHHGQCHISDQGEPY-CLCQPGFSGEHCQQ- 1445
Query: 348 EHACTSNPC---------------ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
NPC A+ + +VP EC G GP C
Sbjct: 1446 -----ENPCLGQVVREVIRRQKGYASCATASKVPI-MECR---GGCGPQCCQPTRSKRRK 1496
Query: 393 ---PCAAGGTCVDQVD-GFECIC 411
C G + V++V+ EC C
Sbjct: 1497 YVFQCTDGSSFVEEVERHLECGC 1519
Score = 60.8 bits (146), Expect = 7e-09
Identities = 51/171 (29%), Positives = 71/171 (41%), Gaps = 32/171 (18%)
Query: 273 CDECVPYPGCVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP 328
C C C HG C + C C W G LCD++ H C + G C+ A
Sbjct: 1332 CKSCTV---CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCV-ATG 1386
Query: 329 DQYRCTCPDGYSGRNCEK---AEHACTSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCAL 384
Y C C +GY G C+ + +AC++ C + G CH G C C G+SG C
Sbjct: 1387 TSYMCKCAEGYGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
Query: 385 DIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC----QLDVNDCRGQC 431
+ NPC G V +V Q A+C ++ + +CRG C
Sbjct: 1446 E------NPCL--GQVVREV------IRRQKGYASCATASKVPIMECRGGC 1482
Score = 60.8 bits (146), Expect = 7e-09
Identities = 37/124 (29%), Positives = 48/124 (38%), Gaps = 11/124 (8%)
Query: 389 CASNPCAAGGTCVD-QVDGFECICPEQWVGATCQLDVND-CRGQCQHGGTCKDLVNGYQC 446
C S G C + D C C W G C + D C G H G C Y C
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMC 1391
Query: 447 VCPRGFGGRHCELERDE---CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE 503
C G+GG C+ + D C++ CH G +C C GFSG C+ +
Sbjct: 1392 KCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQ------Q 1445
Query: 504 PSPC 507
+PC
Sbjct: 1446 ENPC 1449
Score = 57.4 bits (137), Expect = 8e-08
Identities = 46/157 (29%), Positives = 68/157 (43%), Gaps = 28/157 (17%)
Query: 215 NDFFGHYTC-DQYGNKACM--DGWMGKECKEAV--CKQGCNLL-HGGCTVPGE----CRC 264
ND + TC D N C+ + G+ C E + C NL H +P + C C
Sbjct: 1003 NDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCEC 1062
Query: 265 SYGWQGRFC----DECVPYPGCVHGS-CVEP---WQCNCETNWGGLLCDK-------DLN 309
G+ G+ C D+CV + C HG+ CV+ + C C + G C+ +
Sbjct: 1063 VPGYSGKLCETDNDDCVAHK-CRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTS 1121
Query: 310 YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
C + C NG CI + + C CP G++G CEK
Sbjct: 1122 PCDQYE-CQNGAQCIVVQQEP-TCRCPPGFAGPRCEK 1156
Score = 56.2 bits (134), Expect = 2e-07
Identities = 30/97 (30%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 734 SFSCICRDGWEGRTCTHNTND-CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE 792
S C CR GW G C D C C++G G ++ C+CA G+ G C D
Sbjct: 1350 SVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYM-CKCAEGYGGDLCDNKNDS 1408
Query: 793 ---CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQE 826
C + C +G + + C C PG +G CQ+
Sbjct: 1409 ANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
Score = 48.1 bits (113), Expect = 5e-05
Identities = 38/140 (27%), Positives = 52/140 (37%), Gaps = 32/140 (22%)
Query: 507 CRNGARCYNLEGD-YYCACPDDFGGKNCSVP-REPCPGGACRVIDGCGSDAGPGMPGTAA 564
C++G C ++E D C C + G C R+PC G C
Sbjct: 1338 CKHGL-CRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCH------------------ 1378
Query: 565 SGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD---CLGQPCRNGGTCIDEVDAFR 621
HG+CV+ G ++ C C G+ G C D C C +G I +
Sbjct: 1379 ------HGKCVAT-GTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPY 1431
Query: 622 CFCPSGWEGELCDTNPNDCL 641
C C G+ GE C N CL
Sbjct: 1432 CLCQPGFSGEHCQ-QENPCL 1450
Score = 32.7 bits (73), Expect = 2.1
Identities = 42/177 (23%), Positives = 62/177 (35%), Gaps = 27/177 (15%)
Query: 793 CQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG---FGRSCWSRGTPFPHGSSWV 848
C+S + C +G E + C C PG GP C + G C G G+S++
Sbjct: 1332 CKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYM 1390
Query: 849 EDCNSCRCLDG------------RRDCSKVWCGWKPCLLA--GQPEALSAQCPLGQRCLE 894
C+C +G CS C C ++ G+P L G+ C +
Sbjct: 1391 -----CKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQ 1445
Query: 895 KAP--GQCLRPPCEAW-GECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGT 948
+ P GQ +R G P + G C + T R +V Q T
Sbjct: 1446 ENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCT 1502
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 209 bits (532), Expect = 1e-53
Identities = 203/738 (27%), Positives = 261/738 (35%), Gaps = 182/738 (24%)
Query: 276 CVPYPG--CVHGSCVEPWQCNCETNWGGLLCDKDL------NYCGSHHPCTNGGTCINAE 327
CVP CVHG CV P QC C W G C + C C N +C +
Sbjct: 101 CVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSC---D 157
Query: 328 PDQYRCTCPDGYSGRNCEKAEHACTSN----PCANGGSCHEVPSGFE---CHCPSGWSGP 380
P C+CP G NC + CT C CH P + C CP+ +GP
Sbjct: 158 PKSGVCSCPSGLQPPNCLQ---PCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGP 214
Query: 381 TCALDIDECAS-------NPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQH 433
+C + + S + C GG V Q C CP W+G C L
Sbjct: 215 SCDVSCSQGTSGFFCPSTHSCQNGG--VFQTPQGSCSCPPGWMGTICSLP---------- 262
Query: 434 GGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGP 493
CP GF G +C EC CH+GGLC+ C C G++G
Sbjct: 263 --------------CPEGFHGPNCS---QECR---CHNGGLCDRFTG--QCRCAPGYTGD 300
Query: 494 LCEVDV-------DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGG--- 543
C + D E C ARC+ G C C F G C+ CP G
Sbjct: 301 RCREECPVGRFGQDCAETCDCAPDARCFPANG--ACLCEHGFTGDRCT--DRLCPDGFYG 356
Query: 544 -ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 602
+C+ C + S C P N C C G+ G +C+E+
Sbjct: 357 LSCQAPCTCDRE---------HSLSCHPM---------NGECSCLPGWAGLHCNESCPQD 398
Query: 603 LGQP-------CRNGGTCIDEVDAFRCFCPSGWEGELC-DTNPNDCLPDPCHSRGRCYDL 654
P C +GG C + + C C G+ G C P D C +R C +
Sbjct: 399 THGPGCQEHCLCLHGGVC--QATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENA 456
Query: 655 VN----DFYCACDDGWKGKTCH------SREFQCDA-YTCSNGGTCYDSGDTFRCACPPG 703
+ D C C +GW+ C + F C+A C++ C S T C C PG
Sbjct: 457 IACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVC--SPQTGACTCTPG 514
Query: 704 WKGSTCAVAKNSSCLPNPCVNGGTCVGSG----ASFSCICRDGWEGRTC-------THNT 752
W G+ C + C + C S C C+ GW G C
Sbjct: 515 WHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGV 574
Query: 753 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCV------- 805
N N C NGG C+ C CAPGF GP C+ CQ P YG CV
Sbjct: 575 NCSNTCTCKNGGTCLPENG--NCVCAPGFRGPSCQ---RSCQ--PGRYGKRCVPCKCANH 627
Query: 806 ---DEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDC-NSCRC----- 856
NG C C G GP C + P P G W E+C +C+C
Sbjct: 628 SFCHPSNG-TCYCLAGWTGPDCSQ-------------PCPPG-HWGENCAQTCQCHHGGT 672
Query: 857 ---LDGRRDCSKVWCGWK-----PCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAW 908
DG C W G P G + QC G++C G C+ PP +
Sbjct: 673 CHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKC-HPETGACVCPPGHSG 731
Query: 909 GEC--GAEEP----PSTP 920
C G +EP P+TP
Sbjct: 732 APCRIGIQEPFTVMPTTP 749
Score = 199 bits (506), Expect = 1e-50
Identities = 196/692 (28%), Positives = 250/692 (36%), Gaps = 170/692 (24%)
Query: 244 VCKQGCNLLHGGCTVPGECRCSYGWQGRFC-DECVPYPGCVHGSCVEPWQC----NCETN 298
+C Q C +HG C P +C+C GW+G C EC PG C +P C +C+
Sbjct: 104 LCAQEC--VHGRCVAPNQCQCVPGWRGDDCSSECA--PGMWGPQCDKPCSCGNNSSCDPK 159
Query: 299 WGGLLCDKDLNYCGSHHPCTNG---------GTCINA--EPDQYRCTCPDGYSGRNCEKA 347
G C L PCT G C A +P C CP +G +C+ +
Sbjct: 160 SGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVS 219
Query: 348 EHACTS-------NPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP------- 393
TS + C NGG + P G C CP GW G C+L E P
Sbjct: 220 CSQGTSGFFCPSTHSCQNGG-VFQTPQG-SCSCPPGWMGTICSLPCPEGFHGPNCSQECR 277
Query: 394 CAAGGTCVDQVDGFECICPEQWVGATCQLDV------NDCRGQCQ----------HGG-T 436
C GG C D+ G +C C + G C+ + DC C +G
Sbjct: 278 CHNGGLC-DRFTG-QCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACL 335
Query: 437 CKDLVNGYQC---VCPRGFGGRHCE--LERDECASSPCH-SGGLCEDLAD--GFHCH--C 486
C+ G +C +CP GF G C+ D S CH G C L G HC+ C
Sbjct: 336 CEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESC 395
Query: 487 PQGFSGP------------LCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS 534
PQ GP +C+ LC+ +P G C +L CP D G NCS
Sbjct: 396 PQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASL-------CPPDTYGVNCS 448
Query: 535 VPREPCPGG-ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG---GNFSCICDSGF 590
R C AC ID G CV + G GN S C G
Sbjct: 449 A-RCSCENAIACSPID----------------------GECVCKEGWQRGNCSVPCPPGT 485
Query: 591 TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN-PNDCLPDPCHSRG 649
G C+ + C + C + A C C GW G C P + C SR
Sbjct: 486 WGFSCNASCQ------CAHEAVCSPQTGA--CTCTPGWHGAHCQLPCPKGQFGEGCASRC 537
Query: 650 RC-----YDLVNDFYCACDDGWKGKTCHSREFQC----------DAYTCSNGGTCYDSGD 694
C D V+ C C GW G CH C + TC NGGTC +
Sbjct: 538 DCDHSDGCDPVHG-RCQCQAGWMGARCH---LSCPEGLWGVNCSNTCTCKNGGTCLP--E 591
Query: 695 TFRCACPPGWKGSTCAVA-----KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCT 749
C C PG++G +C + C+P C N C S +C C GW G C+
Sbjct: 592 NGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNG--TCYCLAGWTGPDCS 649
Query: 750 H-------NTNDCNPLPCYNGGIC--VDGVNWFRCECAPGFAGPDC-------RINIDEC 793
N C++GG C DG C C G+ G C +
Sbjct: 650 QPCPPGHWGENCAQTCQCHHGGTCHPQDG----SCICPLGWTGHHCLEGCPLGTFGANCS 705
Query: 794 QSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 825
Q C G C E C CPPG +G C+
Sbjct: 706 QPCQCGPGEKCHPETGA--CVCPPGHSGAPCR 735
Score = 190 bits (483), Expect = 6e-48
Identities = 198/726 (27%), Positives = 260/726 (35%), Gaps = 176/726 (24%)
Query: 195 RVRCDENYYSATCNKFCRPR-NDFFGHYTCDQYGNKACMDGWMGKECKEAV--------C 245
R++C +Y + FC P H C C+ GW G +C C
Sbjct: 87 RLQCCHGFYES--RGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQC 144
Query: 246 KQGCNLLHGGCTVP--GECRCSYGWQGRFC-DECVP---YPGC-----VHGSCVEP--WQ 292
+ C+ + P G C C G Q C C P P C HG+ +P
Sbjct: 145 DKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGA 204
Query: 293 CNCETNWGGLLCDKDLN------YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE- 345
C C G CD + +C S H C NGG + Q C+CP G+ G C
Sbjct: 205 CFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGV---FQTPQGSCSCPPGWMGTICSL 261
Query: 346 ------KAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI------DECASN- 392
+ C NGG C +C C G++G C + +CA
Sbjct: 262 PCPEGFHGPNCSQECRCHNGGLCDRFTG--QCRCAPGYTGDRCREECPVGRFGQDCAETC 319
Query: 393 PCA-------AGGTCVDQ--VDGFEC---ICPEQWVGATCQLDVNDCRGQCQHGGTCKDL 440
CA A G C+ + G C +CP+ + G +CQ C +H +C +
Sbjct: 320 DCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQA---PCTCDREHSLSCHPM 376
Query: 441 VNGYQCVCPRGFGGRHCELERDECASSP-------CHSGGLCEDLADGFHCHCPQGFSGP 493
NG +C C G+ G HC + P C GG+C+ A C C G++GP
Sbjct: 377 -NG-ECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQ--ATSGLCQCAPGYTGP 432
Query: 494 LCEVDVDLCEPS----------PCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGG 543
C LC P C N C ++G+ C C + + NCSV PCP G
Sbjct: 433 HC---ASLCPPDTYGVNCSARCSCENAIACSPIDGE--CVCKEGWQRGNCSV---PCPPG 484
Query: 544 ----ACRVIDGCGSDAGPGMPGTAASGVCGPH-GRCVSQP---GGNFSCICDSGFTGTYC 595
+C C +A VC P G C P G + C G G C
Sbjct: 485 TWGFSCNASCQCAHEA-----------VCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGC 533
Query: 596 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN----------PNDCLPDPC 645
D C + C D V RC C +GW G C + N C C
Sbjct: 534 ASRCD------CDHSDGC-DPVHG-RCQCQAGWMGARCHLSCPEGLWGVNCSNTC---TC 582
Query: 646 HSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ-------CDAYTCSNGGTCYDSGDTFRC 698
+ G C L + C C G++G +C R Q C C+N C+ S T C
Sbjct: 583 KNGGTC--LPENGNCVCAPGFRGPSC-QRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYC 639
Query: 699 -----------ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT 747
CPPG G CA +C C +GGTC SCIC GW G
Sbjct: 640 LAGWTGPDCSQPCPPGHWGENCA----QTC---QCHHGGTCHPQDG--SCICPLGWTGHH 690
Query: 748 C-------THNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDE----CQSS 796
C T N P C G C C C PG +G CRI I E ++
Sbjct: 691 CLEGCPLGTFGANCSQPCQCGPGEKCHPETG--ACVCPPGHSGAPCRIGIQEPFTVMPTT 748
Query: 797 PCAYGA 802
P AY +
Sbjct: 749 PVAYNS 754
Score = 70.9 bits (172), Expect = 7e-12
Identities = 95/391 (24%), Positives = 124/391 (31%), Gaps = 115/391 (29%)
Query: 571 HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL-----GQPCRNGGTCIDEVDAFRCFCP 625
HGRCV+ C C G+ G C + +PC G + + C CP
Sbjct: 111 HGRCVAPN----QCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCP 166
Query: 626 SGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSN 685
SG + P +CL C G+ G C +F+C +
Sbjct: 167 SGLQ-------PPNCLQP------------------CTPGYYGPAC---QFRCQCH---- 194
Query: 686 GGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGA----SFSCICRD 741
G C T C CP G +C V+ + C + +C G SC C
Sbjct: 195 GAPC--DPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPP 252
Query: 742 GWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYG 801
GW G C+ LPC GF GP+C EC+ C G
Sbjct: 253 GWMGTICS--------LPC-----------------PEGFHGPNCS---QECR---CHNG 281
Query: 802 ATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN---SCRCLD 858
C D G +C C PG G RC+E GR G E C+ RC
Sbjct: 282 GLC-DRFTG-QCRCAPGYTGDRCREECPVGR----------FGQDCAETCDCAPDARCFP 329
Query: 859 GRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEK-APGQCLRPPCEAWGECGAEEPP 917
C L G RC ++ P C+A C +
Sbjct: 330 ANGAC------------------LCEHGFTGDRCTDRLCPDGFYGLSCQA--PCTCDREH 369
Query: 918 STPCLPRSGHLDNNCARLTLHFNRDHVPQGT 948
S C P +G LH N + PQ T
Sbjct: 370 SLSCHPMNGECSCLPGWAGLHCN-ESCPQDT 399
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.497
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,971,137
Number of Sequences: 37866
Number of extensions: 3922855
Number of successful extensions: 27089
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 223
Number of HSP's successfully gapped in prelim test: 304
Number of HSP's that attempted gapping in prelim test: 9571
Number of HSP's gapped (non-prelim): 5274
length of query: 1200
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1086
effective length of database: 13,930,794
effective search space: 15128842284
effective search space used: 15128842284
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.