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Search of human proteins with 21704277
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
(1238 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 2774 0.0
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 2375 0.0
gi|4557679 jagged 1 precursor [Homo sapiens] 1457 0.0
gi|148833508 notch1 preproprotein [Homo sapiens] 530 e-150
gi|24041035 notch 2 preproprotein [Homo sapiens] 512 e-145
gi|134244285 Notch homolog 3 [Homo sapiens] 491 e-138
gi|110735443 delta-like 1 [Homo sapiens] 481 e-135
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 479 e-135
gi|55770876 notch4 preproprotein [Homo sapiens] 465 e-130
gi|122937283 6720455I24Rik homolog [Homo sapiens] 380 e-105
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 373 e-103
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 306 8e-83
gi|112420992 crumbs homolog 2 [Homo sapiens] 301 2e-81
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 257 5e-68
gi|66346695 fibrillin 2 precursor [Homo sapiens] 242 2e-63
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 234 5e-61
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 229 2e-59
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 227 6e-59
gi|148886654 polydom [Homo sapiens] 225 2e-58
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 222 2e-57
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 222 2e-57
gi|110347437 latent transforming growth factor beta binding prot... 221 3e-57
gi|110347412 latent transforming growth factor beta binding prot... 221 3e-57
gi|110347431 latent transforming growth factor beta binding prot... 221 3e-57
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 217 6e-56
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 217 6e-56
gi|56237021 fibrillin 3 precursor [Homo sapiens] 215 2e-55
gi|153946395 tenascin C precursor [Homo sapiens] 214 5e-55
gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens] 213 7e-55
gi|188528675 slit homolog 1 [Homo sapiens] 211 5e-54
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 2774 bits (7191), Expect = 0.0
Identities = 1238/1238 (100%), Positives = 1238/1238 (100%)
Query: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
Sbjct: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
Query: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
Sbjct: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
Query: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS
Sbjct: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
Query: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC
Sbjct: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
Query: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG 300
KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG
Sbjct: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWG 300
Query: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG
Sbjct: 301 GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
Query: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC
Sbjct: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
Query: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN 480
QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN
Sbjct: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVN 480
Query: 481 GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC 540
GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC
Sbjct: 481 GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC 540
Query: 541 EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 600
EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT
Sbjct: 541 EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGT 600
Query: 601 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 660
AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC
Sbjct: 601 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC 660
Query: 661 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 720
FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT
Sbjct: 661 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 720
Query: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG
Sbjct: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
Query: 781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 840
WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA
Sbjct: 781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 840
Query: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 900
TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD
Sbjct: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 900
Query: 901 CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL 960
CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL
Sbjct: 901 CSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCL 960
Query: 961 PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG 1020
PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG
Sbjct: 961 PRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSG 1020
Query: 1021 ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST 1080
ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST
Sbjct: 1021 ASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTGGSST 1080
Query: 1081 GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER 1140
GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER
Sbjct: 1081 GLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRNPIER 1140
Query: 1141 PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK 1200
PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK
Sbjct: 1141 PGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKFLSHK 1200
Query: 1201 FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1238
FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
Sbjct: 1201 FTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1238
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 2375 bits (6154), Expect = 0.0
Identities = 1086/1242 (87%), Positives = 1113/1242 (89%), Gaps = 46/1242 (3%)
Query: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG
Sbjct: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
Query: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR
Sbjct: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
Query: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS
Sbjct: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWKS 180
Query: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKEC 240
LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDG
Sbjct: 181 LHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDG------ 234
Query: 241 KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC--VHGSCVEPWQCNCETN 298
W G+ C E V GC +HG C P +C C
Sbjct: 235 ---------------------------WMGKECKEAVCKQGCNLLHGGCTVPGECRCSYG 267
Query: 299 WGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSN-PCA 357
W G CD+ + Y G H G+C+ + ++C C + G C+K + C S+ PC
Sbjct: 268 WQGRFCDECVPYPGCVH-----GSCV----EPWQCNCETNWGGLLCDKDLNYCGSHHPCT 318
Query: 358 NGGSC-HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWV 416
NGG+C + P + C CP G+SG C C SNPCA GG+C + GFEC CP W
Sbjct: 319 NGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWS 378
Query: 417 GATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCK 476
G TC LD +EC PC +C + + G+ C C W G C ++VNDCRGQCQHGGTCK
Sbjct: 379 GPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQHGGTCK 438
Query: 477 DLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 536
DLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD
Sbjct: 439 DLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 498
Query: 537 VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 596
VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG
Sbjct: 499 VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 558
Query: 597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD 656
MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD
Sbjct: 559 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD 618
Query: 657 AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716
AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC
Sbjct: 619 AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 678
Query: 717 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 776
DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI
Sbjct: 679 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 738
Query: 777 CRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPC 836
CRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPC
Sbjct: 739 CRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPC 798
Query: 837 AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 896
AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD
Sbjct: 799 AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 858
Query: 897 GRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPS 956
GRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPS
Sbjct: 859 GRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPS 918
Query: 957 TPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDR 1016
TPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDR
Sbjct: 919 TPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLLCDR 978
Query: 1017 ASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTG 1076
ASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTG
Sbjct: 979 ASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQRGNSSLLLAVTEVKVETVVTG 1038
Query: 1077 GSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRN 1136
GSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRN
Sbjct: 1039 GSSTGLLVPVLCGAFSVLWLACVVLCVWWTRKRRKERERSRLPREESANNQWAPLNPIRN 1098
Query: 1137 PIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKF 1196
PIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKF
Sbjct: 1099 PIERPGGHKDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRGEEDSLEAEKF 1158
Query: 1197 LSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1238
LSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE
Sbjct: 1159 LSHKFTKDPGRSPGRPAHWASGPKVDNRAVRSINEARYAGKE 1200
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 1457 bits (3771), Expect = 0.0
Identities = 667/1251 (53%), Positives = 845/1251 (67%), Gaps = 57/1251 (4%)
Query: 2 RAQGRGRLPRRLLLLL--ALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRA 59
R +GR P LLL L AL + G FEL++ +++NVNGEL +G CC G R
Sbjct: 5 RTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGG-ARNPGD 63
Query: 60 GGCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARA 119
C DECDTY +VCLKEYQ++VT GPCS+G G+TPV+GGN+F L A DR R
Sbjct: 64 RKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLK-ASRGNDRNR--- 119
Query: 120 RAGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEELLIERVSHAGMINPEDRWK 179
+V+PF FAWPRS+TL+VEAWD NDT + + IE+ SH+GMINP +W+
Sbjct: 120 ----------IVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSI-IEKASHSGMINPSRQWQ 168
Query: 180 SLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKE 239
+L + VAH E QIRV CD+ YY CNKFCRPR+DFFGHY CDQ GNK CM+GWMG E
Sbjct: 169 TLKQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPE 228
Query: 240 CKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNW 299
C A+C+QGC+ HG C +PG+CRC YGWQG +CD+C+P+PGCVHG C EPWQC CETNW
Sbjct: 229 CNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCETNW 288
Query: 300 GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANG 359
GG LCDKDLNYCG+H PC NGGTC N PD+Y+C+CP+GYSG NCE AEHAC S+PC N
Sbjct: 289 GGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNR 348
Query: 360 GSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGAT 419
GSC E GFEC C GW+GPTC+ +ID+C+ N C+ GGTC D V+GF+C+CP QW G T
Sbjct: 349 GSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKT 408
Query: 420 CQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLV 479
CQLDANECE KPC+NA SCKNLI YYCDC+PGW G NC IN+NDC GQCQ+ +C+DLV
Sbjct: 409 CQLDANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLV 468
Query: 480 NGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 539
NGY+C+CP G+ G HCE + DECAS+PC +GG C++ + F C CP GFSG LC++D+D
Sbjct: 469 NGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY 528
Query: 540 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC----GSDAGP 595
CEP+PC+NGA+CYN DY+C CP+D+ GKNCS ++ C C VID C S+ P
Sbjct: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
Query: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEV 655
+S VCGPHG+C SQ GG F+C C+ GFTGTYCHENI+DC PCRNGGTCID V
Sbjct: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
Query: 656 DAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ 715
++++C C GWEG C+TN NDC +PCH+ G C DLVNDFYC C +GWKGKTCHSR+ Q
Sbjct: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
Query: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
CD TC+NGGTCYD GD F+C CP GW+G+TC +A+NSSCLPNPC NGGTCV +G SF+C
Sbjct: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTC 768
Query: 776 ICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP 835
+C++GWEG C NTNDC+P PCYN G CVDG NW+RCECAPGFAGPDCRINI+ECQSSP
Sbjct: 769 VCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRININECQSSP 828
Query: 836 CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895
CA+GATCVDEINGYRC CPPG +G +CQEV GR C + G+ P G+ W +DCN+C+CL
Sbjct: 829 CAFGATCVDEINGYRCVCPPGHSGAKCQEV--SGRPCITMGSVIPDGAKWDDDCNTCQCL 886
Query: 896 DGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAE--E 953
+GR CSKVWCG +PCLL ++CP GQ C+ QC PC GEC + +
Sbjct: 887 NGRIACSKVWCGPRPCLL----HKGHSECPSGQSCIPILDDQCFVHPCTGVGECRSSSLQ 942
Query: 954 PPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGAICSGIRSLPATRAVARDRLLVLL 1013
P T C S + D NCA +T FN++ + G T ICS +R+L + V+ + + +
Sbjct: 943 PVKTKCTSDSYYQD-NCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEYSIYIA 1001
Query: 1014 CDRASSGASAVEVAVSFSPARDLPDSSLIQGAAHAIVAAITQR-GNSSLLLAVTEVKVET 1072
C+ + S + + VA+S RD D + I+ I+ +++R GNSSL+ AV EV+V+
Sbjct: 1002 CEPSPSANNEIHVAISAEDIRD--DGNPIKEITDKIIDLVSKRDGNSSLIAAVAEVRVQR 1059
Query: 1073 VVTGGSSTGLLVPVLCGAFSVLWLACVVLCVWW-TRKRRKERERSRLPREE-SANNQWAP 1130
+ T LVP+L +V W+ C+V +W RKRRK + E+ + NN
Sbjct: 1060 RPL-KNRTDFLVPLLSSVLTVAWICCLVTAFYWCLRKRRKPGSHTHSASEDNTTNNVREQ 1118
Query: 1131 LNPIRNPIERPGGH----KDVLYQCKNFTPPPRRADEALPGPAGHAAVREDEEDEDLGRG 1186
LN I+NPIE+ G + KD Y+ KN R ++ V ED+ D+ +
Sbjct: 1119 LNQIKNPIEKHGANTVPIKD--YENKNSKMSKIRTH--------NSEVEEDDMDKHQQKA 1168
Query: 1187 EEDSLEAEKFLSHKFTKDPGRSPGRPAHWASGPKVDNR---AVRSINEARY 1234
A + + K P +P + +W + K DNR + +S+N Y
Sbjct: 1169 RFAKQPAYTLVDRE-EKPPNGTPTKHPNWTN--KQDNRDLESAQSLNRMEY 1216
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 530 bits (1365), Expect = e-150
Identities = 286/811 (35%), Positives = 387/811 (47%), Gaps = 116/811 (14%)
Query: 239 ECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC----DECVPYPGCVHGSC---VEPW 291
EC CK G L G T C C+ G+ G C DEC P P C +GSC V +
Sbjct: 531 ECASTPCKNGAKCLDGPNTYT--CVCTEGYTGTHCEVDIDECDPDP-CHYGSCKDGVATF 587
Query: 292 QCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC 351
C C + G C+ ++N C S PC +GGTC + + + Y C C G +G NCE C
Sbjct: 588 TCLCRPGYTGHHCETNINECSSQ-PCRHGGTCQDRD-NAYLCFCLKGTTGPNCEINLDDC 645
Query: 352 TSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411
S+PC + G+C + G+EC C G++G C ++IDECA NPC GGTC D ++GF C C
Sbjct: 646 ASSPC-DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRC 704
Query: 412 PEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQ 470
PE + TC + NEC PC++ +C++ + GY CDC PGW G NC IN N+C C
Sbjct: 705 PEGYHDPTCLSEVNECNSNPCVHG-ACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCV 763
Query: 471 HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC------ 524
+GGTCKD+ +GY C C GF G +C+ +ECAS+PC + G C D G+ C+C
Sbjct: 764 NGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTG 823
Query: 525 ----------------------------------PQGFSGPLCEVDVDLCEPSPCRNGAR 550
P G+ G CEVD++ C SPCR+GA
Sbjct: 824 ATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGAS 883
Query: 551 CYNLEGDYYCACPDDFGGKNCSVPREPCP------GGACRVIDGCGS---DAGPGMPGT- 600
C N G Y C C + G+NC + C GG+C DG + D PG GT
Sbjct: 884 CQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCT--DGINTAFCDCLPGFRGTF 941
Query: 601 -------AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCID 653
AS C C +++C C +GF+G +C N DC C NGGTC+D
Sbjct: 942 CEEDINECASDPCRNGANCTDCVD-SYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVD 1000
Query: 654 EVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSRE 713
+++F C CP G+ G C + N+C PC G C D + C C G+ G C +
Sbjct: 1001 GINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLV 1060
Query: 714 FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC----------LPNPCVNG 763
CD+ C NGG C+ + +RC CP GW G C V + SC + C +G
Sbjct: 1061 HWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVP-SVSCEVAAQRQGVDVARLCQHG 1119
Query: 764 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 823
G CV +G + C C+ G+ G C ++C+P PC NG C D + + C+C G+ G +
Sbjct: 1120 GLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVN 1179
Query: 824 CRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
C IDEC S PC G TC+D N Y+CSCP G G C+ + C P S
Sbjct: 1180 CSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVD---DC---NPPVDPVS 1233
Query: 884 SWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP---LGQRCLEKAPGQCLR 940
+ N+ C+D Q S CP +G+RC E +CL
Sbjct: 1234 RSPKCFNNGTCVD-------------------QVGGYSCTCPPGFVGERC-EGDVNECLS 1273
Query: 941 PPCEAWG-ECGAEEPPSTPCLPRSGHLDNNC 970
PC+A G + + C R+GH C
Sbjct: 1274 NPCDARGTQNCVQRVNDFHCECRAGHTGRRC 1304
Score = 510 bits (1314), Expect = e-144
Identities = 281/810 (34%), Positives = 389/810 (48%), Gaps = 74/810 (9%)
Query: 211 CRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGCTVPG----ECRC 264
CRP D + C AC+ G+ G+ C+E + C G N +GG V G CRC
Sbjct: 233 CRPTGDVT--HEC------ACLPGFTGQNCEENIDDC-PGNNCKNGGACVDGVNTYNCRC 283
Query: 265 SYGWQGRFC----DECVPYPGCVH--GSCVEP---WQCNCETNWGGLLCDKDLNYCGSHH 315
W G++C DEC P G+C + C C W G C ++++ C S
Sbjct: 284 PPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCAS-A 342
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE--CHC 373
C +G TC + Y C CP G +G C AC SNPC G +C P + C C
Sbjct: 343 ACFHGATCHDRVASFY-CECPHGRTGLLCH-LNDACISNPCNEGSNCDTNPVNGKAICTC 400
Query: 374 PSGWSGPTCALDIDECA--SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKP 431
PSG++GP C+ D+DEC+ +NPC G C++ + FEC C + + G C++D NEC P
Sbjct: 401 PSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNP 460
Query: 432 CLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGF 490
C N +C + IG + C C+PG++G++C +N ++C C H G C D +N +QC CP GF
Sbjct: 461 CQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGF 520
Query: 491 GGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGAR 550
G C+ + DECAS+PC +G C D + + C C +G++G CEVD+D C+P PC G+
Sbjct: 521 TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGS- 579
Query: 551 CYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPH- 609
C + + C C + G +C C CR C D G GP+
Sbjct: 580 CKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTC-QDRDNAYLCFCLKGTTGPNC 638
Query: 610 --------------GRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEV 655
G C+ + G + C C+ G+TG+ C+ NID+C G PC NGGTC D +
Sbjct: 639 EINLDDCASSPCDSGTCLDKIDG-YECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGI 697
Query: 656 DAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ 715
+ F C CP G+ C + N+C +PC G C D +N + C CD GW G C +
Sbjct: 698 NGFTCRCPEGYHDPTCLSEVNECNSNPC-VHGACRDSLNGYKCDCDPGWSGTNCDINNNE 756
Query: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
C++ C NGGTC D + C C G+ G C N C NPC+N GTC+ A + C
Sbjct: 757 CESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNIN-ECASNPCLNQGTCIDDVAGYKC 815
Query: 776 ICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW--FRCECAPGFAGPDCRINIDECQS 833
C + G TC C P PC NGG C ++ F C C G+ G C ++I+EC
Sbjct: 816 NCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVL 875
Query: 834 SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS-- 891
SPC +GA+C + GYRC C G +G C+ I C R P +G S + N+
Sbjct: 876 SPCRHGASCQNTHGGYRCHCQAGYSGRNCETDID---DC--RPNPCHNGGSCTDGINTAF 930
Query: 892 CRCLDGRRD--CSK--VWCGWKPCLLAGQ----PEALSAQCPL---GQRCLEKAPGQCLR 940
C CL G R C + C PC ++ + CP G C P C
Sbjct: 931 CDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTP-DCTE 989
Query: 941 PPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
C G C + S CL G + C
Sbjct: 990 SSCFNGGTC-VDGINSFTCLCPPGFTGSYC 1018
Score = 509 bits (1310), Expect = e-144
Identities = 260/787 (33%), Positives = 362/787 (45%), Gaps = 122/787 (15%)
Query: 228 NKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC---DECVPY 279
N C++GW G++C E + G T C C +G G C D C+
Sbjct: 320 NCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISN 379
Query: 280 PGCVHGSCVEPWQ------CNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAEPDQYR 332
P C GS + C C + + G C +D++ C +PC + G CIN +
Sbjct: 380 P-CNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTL-GSFE 437
Query: 333 CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
C C GY+G CE + C SNPC N +C + F+C C G+ G C ++ DECAS+
Sbjct: 438 CQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASS 497
Query: 393 PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAF---------------- 436
PC G C+D+++ F+C CP + G CQ D +EC PC N
Sbjct: 498 PCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEG 557
Query: 437 ---------------------SCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGT 474
SCK+ + + C C PG+ G +C N+N+C Q C+HGGT
Sbjct: 558 YTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGT 617
Query: 475 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
C+D N Y C C +G G +CE+ D+CASSPC S G C D DG+ C C G++G +C
Sbjct: 618 CQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDS-GTCLDKIDGYECACEPGYTGSMCN 676
Query: 535 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC-----SVPREPCPGGACR-VIDG 588
+++D C +PC NG C + + C CP+ + C PC GACR ++G
Sbjct: 677 INIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNG 736
Query: 589 CGSDAGPGMPGT--------AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDC 640
D PG GT S C G C G + C C GF+G C NI++C
Sbjct: 737 YKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSG-YVCTCREGFSGPNCQTNINEC 795
Query: 641 LGQPCRNGGTCIDEV----------------------------------------DAFRC 660
PC N GTCID+V ++F C
Sbjct: 796 ASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSC 855
Query: 661 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT 720
CP+GW+G+ C+ + N+C+ PC C + + C C G+ G+ C + C
Sbjct: 856 VCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNP 915
Query: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
C NGG+C D +T C C PG++G+ C N C +PC NG C S++C C G
Sbjct: 916 CHNGGSCTDGINTAFCDCLPGFRGTFCEEDIN-ECASDPCRNGANCTDCVDSYTCTCPAG 974
Query: 781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 840
+ G C +NT DC C+NGG CVDG+N F C C PGF G C+ +++EC S PC +G
Sbjct: 975 FSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGG 1034
Query: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 900
TC D YRC+CP G GP CQ ++ W +P +G + RC +
Sbjct: 1035 TCQDGCGSYRCTCPQGYTGPNCQNLVH-----WCDSSPCKNGGKCWQTHTQYRC-----E 1084
Query: 901 CSKVWCG 907
C W G
Sbjct: 1085 CPSGWTG 1091
Score = 499 bits (1284), Expect = e-141
Identities = 262/773 (33%), Positives = 382/773 (49%), Gaps = 68/773 (8%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC----DECVPYPG 281
C+ G+ G C+ V + N T + C C G++G C DEC P
Sbjct: 440 CLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPC 499
Query: 282 CVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
+G C++ +QC C T + G LC D++ C S PC NG C++ P+ Y C C +G
Sbjct: 500 LHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAST-PCKNGAKCLDG-PNTYTCVCTEG 557
Query: 339 YSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGG 398
Y+G +CE C +PC + GSC + + F C C G++G C +I+EC+S PC GG
Sbjct: 558 YTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGG 616
Query: 399 TCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC 458
TC D+ + + C C + G C+++ ++C PC ++ +C + I GY C C PG+ G C
Sbjct: 617 TCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPC-DSGTCLDKIDGYECACEPGYTGSMC 675
Query: 459 HINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 517
+IN+++C G C +GGTC+D +NG+ C CP G+ C E +EC S+PC G C D
Sbjct: 676 NINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA-CRDSL 734
Query: 518 DGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP 577
+G+ C C G+SG C+++ + CE +PC NG C ++ Y C C + F G NC
Sbjct: 735 NGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINE 794
Query: 578 CPGGACR-----VIDGCGSDAGPGMPGTAAS-----GVCGPH-----GRC-VSQPGGNFS 621
C C + D G +P T A+ C P G C S+ +FS
Sbjct: 795 CASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFS 854
Query: 622 CICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD 681
C+C +G+ G C +I++C+ PCR+G +C + +RC C +G+ G C+T+ +DC P+
Sbjct: 855 CVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPN 914
Query: 682 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 741
PCH+ G C D +N +C C G++G C +C + C NG C D D++ C CP G
Sbjct: 915 PCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAG 974
Query: 742 WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNG 801
+ G C C + C NGGTCV SF+C+C G+ G C H+ N+C+ PC +G
Sbjct: 975 FSGIHCE-NNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHG 1033
Query: 802 GICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPR 861
G C DG +RC C G+ GP+C+ + C SSPC G C YRC CP G G
Sbjct: 1034 GTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLY 1093
Query: 862 C------------QEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLDGRRD--CSKV- 904
C ++ + R C HG V+ N+ CRC G C +
Sbjct: 1094 CDVPSVSCEVAAQRQGVDVARLC-------QHGGLCVDAGNTHHCRCQAGYTGSYCEDLV 1146
Query: 905 -WCGWKPC----LLAGQPEALSAQCPLGQ---RCLEKAPGQCLRPPCEAWGEC 949
C PC S +C G C E+ +CL PC+ G C
Sbjct: 1147 DECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEI-DECLSHPCQNGGTC 1198
Score = 498 bits (1282), Expect = e-140
Identities = 282/818 (34%), Positives = 383/818 (46%), Gaps = 106/818 (12%)
Query: 240 CKEAVCKQG--CNLLHGGCTVPGECRCSYGWQGRFC---DECVPYPGCVHGSCVEPWQ-- 292
C C+ G C+LL +CRC GW G+ C D C P C +G P++
Sbjct: 106 CLTNPCRNGGTCDLL---TLTEYKCRCPPGWSGKSCQQADPCASNP-CANGGQCLPFEAS 161
Query: 293 --CNCETNWGGLLCDKDLNYCGSHHP-CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEH 349
C+C ++ G C +D+N CG C +GGTC N E YRC C ++G NCE+
Sbjct: 162 YICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHN-EVGSYRCVCRATHTGPNCERPYV 220
Query: 350 ACTSNPCANGGSCHEVPSG---FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG 406
C+ +PC NGG+C P+G EC C G++G C +ID+C N C GG CVD V+
Sbjct: 221 PCSPSPCQNGGTCR--PTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNT 278
Query: 407 FECICPEQWVGATCQLDANECEGKP--CLNAFSCKNLIGGYYCDCIPGWKGINCHINVND 464
+ C CP +W G C D +EC+ P C N +C N GGY C C+ GW G +C N++D
Sbjct: 279 YNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDD 338
Query: 465 C-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCE--DLADGFH 521
C C HG TC D V + C CP G G C L D C S+PC+ G C+ +
Sbjct: 339 CASAACFHGATCHDRVASFYCECPHGRTGLLCHL-NDACISNPCNEGSNCDTNPVNGKAI 397
Query: 522 CHCPQGFSGPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP 579
C CP G++GP C DVD C +PC + +C N G + C C + G C + C
Sbjct: 398 CTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECV 457
Query: 580 GGACRVIDGCGSDAG-------PGMPGT--------AASGVCGPHGRCVSQPGGNFSCIC 624
C+ C G PG G AS C +GRC+ + F C C
Sbjct: 458 SNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKI-NEFQCEC 516
Query: 625 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCH 684
+GFTG C ++D+C PC+NG C+D + + C C G+ G C+ + ++C PDPCH
Sbjct: 517 PTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCH 576
Query: 685 SRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCY---------------- 728
G C D V F C C G+ G C + +C + C +GGTC
Sbjct: 577 -YGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTG 635
Query: 729 ---------------DSG------DTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV 767
DSG D + CAC PG+ GS C + C NPC NGGTC
Sbjct: 636 PNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNI-NIDECAGNPCHNGGTCE 694
Query: 768 GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 827
F+C C +G+ TC N+CN PC +G C D +N ++C+C PG++G +C IN
Sbjct: 695 DGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDIN 753
Query: 828 IDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSW 885
+EC+S+PC G TC D +GY C+C G +GP CQ I C ++GT + +
Sbjct: 754 NNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGY 813
Query: 886 VEDCNSCRCL--DGRRDCSKVW--CGWKPCLLAGQ------PEALSAQCPL---GQRCLE 932
C CL C V C PC G+ E+ S CP GQ C E
Sbjct: 814 -----KCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTC-E 867
Query: 933 KAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
+C+ PC C C ++G+ NC
Sbjct: 868 VDINECVLSPCRHGASC-QNTHGGYRCHCQAGYSGRNC 904
Score = 494 bits (1272), Expect = e-139
Identities = 261/758 (34%), Positives = 377/758 (49%), Gaps = 64/758 (8%)
Query: 262 CRCSYGWQGRFCDE---CVPYPGCVHGSC-------VEPWQCNCETNWGGLLCDKDLNYC 311
C C + G C + C+ P G+C V + C+C + G LC L+
Sbjct: 46 CVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNA 105
Query: 312 GSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFEC 371
+PC NGGTC +Y+C CP G+SG++C++A+ C SNPCANGG C + + C
Sbjct: 106 CLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQAD-PCASNPCANGGQCLPFEASYIC 164
Query: 372 HCPSGWSGPTCALDIDECASNP--CAAGGTCVDQVDGFECICPEQWVGATCQLDANECEG 429
HCP + GPTC D++EC P C GGTC ++V + C+C G C+ C
Sbjct: 165 HCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSP 224
Query: 430 KPCLNAFSCKNLIG-GYYCDCIPGWKGINCHINVNDCRG-QCQHGGTCKDLVNGYQCVCP 487
PC N +C+ + C C+PG+ G NC N++DC G C++GG C D VN Y C CP
Sbjct: 225 SPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCP 284
Query: 488 RGFGGRHCELERDECASSP--CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 545
+ G++C + DEC P C +GG C + G++C C G++G C ++D C + C
Sbjct: 285 PEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAAC 344
Query: 546 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGP---------- 595
+GA C++ +YC CP G C + + C C +G D P
Sbjct: 345 FHGATCHDRVASFYCECPHGRTGLLCHL-NDACISNPCN--EGSNCDTNPVNGKAICTCP 401
Query: 596 -GMPGTAAS----------GVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP 644
G G A S C G+C++ G+F C C G+TG C ++++C+ P
Sbjct: 402 SGYTGPACSQDVDECSLGANPCEHAGKCINTL-GSFECQCLQGYTGPRCEIDVNECVSNP 460
Query: 645 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW 704
C+N TC+D++ F+C C G+EG C+ N ++C PC GRC D +N+F C C G+
Sbjct: 461 CQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGF 520
Query: 705 KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGG 764
G C +C + C NG C D +T+ C C G+ G+ C V C P+PC + G
Sbjct: 521 TGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEV-DIDECDPDPC-HYG 578
Query: 765 TCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 824
+C A+F+C+CR G+ G C N N+C+ PC +GG C D N + C C G GP+C
Sbjct: 579 SCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNC 638
Query: 825 RINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSS 884
IN+D+C SSPC G TC+D+I+GY C+C PG G C I C G P +G +
Sbjct: 639 EINLDDCASSPCDSG-TCLDKIDGYECACEPGYTGSMCNINID---EC--AGNPCHNGGT 692
Query: 885 WVEDCN--SCRCLDGRRD---CSKV-WCGWKPCLLAGQPEALSA-QCPL-----GQRCLE 932
+ N +CRC +G D S+V C PC+ ++L+ +C G C +
Sbjct: 693 CEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNC-D 751
Query: 933 KAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
+C PC G C + C R G NC
Sbjct: 752 INNNECESNPCVNGGTC-KDMTSGYVCTCREGFSGPNC 788
Score = 469 bits (1208), Expect = e-132
Identities = 289/893 (32%), Positives = 387/893 (43%), Gaps = 119/893 (13%)
Query: 197 RCDENYYSATCNKFCRPRN----------DFFGHYTCDQYGNKACMDGWMG-------KE 239
RC E Y+ TC N D Y CD C GW G E
Sbjct: 703 RCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCD------CDPGWSGTNCDINNNE 756
Query: 240 CKEAVCKQG--CNLLHGGCTVPGECRCSYGWQGRFC----DECVPYPGCVHGSCVEP--- 290
C+ C G C + G C C G+ G C +EC P G+C++
Sbjct: 757 CESNPCVNGGTCKDMTSGYV----CTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAG 812
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP-DQYRCTCPDGYSGRNCEKAEH 349
++CNC + G C+ L C PC NGG C +E + + C CP G+ G+ CE +
Sbjct: 813 YKCNCLLPYTGATCEVVLAPCAPS-PCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN 871
Query: 350 ACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFEC 409
C +PC +G SC G+ CHC +G+SG C DID+C NPC GG+C D ++ C
Sbjct: 872 ECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFC 931
Query: 410 ICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-RGQ 468
C + G C+ D NEC PC N +C + + Y C C G+ GI+C N DC
Sbjct: 932 DCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESS 991
Query: 469 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 528
C +GGTC D +N + C+CP GF G +C+ + +EC S PC GG C+D + C CPQG+
Sbjct: 992 CFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGY 1051
Query: 529 SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRV-ID 587
+GP C+ V C+ SPC+NG +C+ Y C CP + G C VP C A R +D
Sbjct: 1052 TGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVD 1111
Query: 588 --------GCGSDAG--------PGMPGTAASGV---CGP----HGRCVSQPGGNFSCIC 624
G DAG G G+ + C P +G + G +SC C
Sbjct: 1112 VARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKC 1171
Query: 625 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP--DP 682
+G+ G C E ID+CL PC+NGGTC+D + ++C CP G +G C+ N +DC P DP
Sbjct: 1172 VAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDP 1231
Query: 683 ------CHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGT--CYDSGDTF 734
C + G C D V + C C G+ G+ C +C + C GT C + F
Sbjct: 1232 VSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDF 1291
Query: 735 RCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTN 791
C C G G C N C PC NGGTC + F C C G+EG TC ++
Sbjct: 1292 HCECRAGHTGRRCESVING-CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDAR 1350
Query: 792 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC--------V 843
C L C NGG C+ G C C F GP+C+ SSPC G C
Sbjct: 1351 TCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFP----ASSPCLGGNPCYNQGTCEPT 1406
Query: 844 DEINGYRCSCPPGRAGPRCQEV-IGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD--GRRD 900
E YRC CP G C + FG R P P E C C + G +
Sbjct: 1407 SESPFYRCLCPAKFNGLLCHILDYSFGGGA-GRDIPPP---LIEEACELPECQEDAGNKV 1462
Query: 901 CSKVWCGWKPCLLAGQPEALS-----AQCPLGQRCLE-----KAPGQCLRPPCEAWG-EC 949
CS + C C G +L+ C +C + QC C G +C
Sbjct: 1463 CS-LQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDC 1521
Query: 950 GAEEPPSTPCLPR-------SGHLDNNCARLTLHFN----RDHVPQGTTVGAI 991
E P + GH D C ++ +HVP+ G +
Sbjct: 1522 QRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTL 1574
Score = 322 bits (826), Expect = 1e-87
Identities = 193/644 (29%), Positives = 269/644 (41%), Gaps = 135/644 (20%)
Query: 429 GKPCLN-------------------------------AFSCKNL----------IGGYYC 447
G+ CLN + CKN + Y C
Sbjct: 28 GETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYAC 87
Query: 448 DCIPGWKGINCHINVNDC--RGQCQHGGTCKDL-VNGYQCVCPRGFGGRHCELERDECAS 504
C G+ G C +++ C++GGTC L + Y+C CP G+ G+ C+ + D CAS
Sbjct: 88 SCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQ-QADPCAS 146
Query: 505 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCAC 562
+PC +GG C + CHCP F GP C DV+ C +P CR+G C+N G Y C C
Sbjct: 147 NPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVC 206
Query: 563 PDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC 622
G NC P PC C+ G C P G + C
Sbjct: 207 RATHTGPNCERPYVPCSPSPCQ-----------------NGGTCRPTGDVTHE------C 243
Query: 623 ICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC--LP 680
C GFTG C ENIDDC G C+NGG C+D V+ + C CP W G+ C + ++C +P
Sbjct: 244 ACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMP 303
Query: 681 DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 740
+ C + G C++ + C C +GW G+ C C + C +G TC+D +F C CP
Sbjct: 304 NACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPH 363
Query: 741 GWKGSTCAVAKNSSCLPNPC----------VNG--------------------------- 763
G G C + N +C+ NPC VNG
Sbjct: 364 GRTGLLCHL--NDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGAN 421
Query: 764 -----GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPG 818
G C+ + SF C C G+ G C + N+C PC N C+D + F+C C PG
Sbjct: 422 PCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPG 481
Query: 819 FAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP 878
+ G C +N DEC SSPC + C+D+IN ++C CP G G CQ + C S TP
Sbjct: 482 YEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVD---ECAS--TP 536
Query: 879 FPHGSSWVEDCN--SCRCLDG----RRDCSKVWCGWKPCLLAGQPEALSAQCPL------ 926
+G+ ++ N +C C +G + C PC + ++ L
Sbjct: 537 CKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYT 596
Query: 927 GQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
G C E +C PC G C + + C G NC
Sbjct: 597 GHHC-ETNINECSSQPCRHGGTC-QDRDNAYLCFCLKGTTGPNC 638
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 512 bits (1318), Expect = e-145
Identities = 255/711 (35%), Positives = 357/711 (50%), Gaps = 84/711 (11%)
Query: 261 ECRCSYGWQGRFCDE----CVPYPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGS 313
EC+C+ G+ G C+E C P P C HG C ++ + C C + G +C ++ C S
Sbjct: 555 ECQCATGFTGVLCEENIDNCDPDP-CHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYS 613
Query: 314 HHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHC 373
PC N G CI+ + Y+C C G SG NCE C SNPC +G C + + + C C
Sbjct: 614 S-PCLNDGRCIDLV-NGYQCNCQPGTSGVNCEINFDDCASNPCIHG-ICMDGINRYSCVC 670
Query: 374 PSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCL 433
G++G C +DIDECASNPC G TC++ V+GF CICPE +C NEC PC+
Sbjct: 671 SPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCI 730
Query: 434 NAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGG 492
+ +C + GY C C GW GINC ++ N+C CQ+GGTC +LVNGY+C C +GF G
Sbjct: 731 HG-NCTGGLSGYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKG 789
Query: 493 RHCELERDECASSPCHSGGLCEDLADGFHCHC---------------------------- 524
+C++ DECAS+PC + G C D G+ CHC
Sbjct: 790 YNCQVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCK 849
Query: 525 ------------PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS 572
G+ G C +D+D C PC N C+N +G Y C CP F G +C
Sbjct: 850 ESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCE 909
Query: 573 VPREPCPGGACR----VIDGCGSDAGPGMPGTAASGVCGPHGRCVSQP---GG------- 618
+ C C+ +DG + + +PG C+S+P GG
Sbjct: 910 EDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVN 969
Query: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
+++C C +GF G +C NI++C C NGGTC+D +++F C CP G+ G C N+C
Sbjct: 970 SYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINEC 1029
Query: 679 LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCAC 738
PC + G C D + + C+C G+ GK C + C C N GTC +C C
Sbjct: 1030 SSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLC 1089
Query: 739 PPGWKGSTCAVAKNSSC----------LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTH 788
P GW G+ C V N SC + + C + G C+ +G + C C G+ G C
Sbjct: 1090 PSGWAGAYCDV-PNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEE 1148
Query: 789 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 848
++C PC +G C D + +RCEC PG+ G +C +DECQ+ PC G TC+D +N
Sbjct: 1149 QLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNH 1208
Query: 849 YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN--SCRCLDG 897
++CSCPPG G C+E I C +RG +G ++ SCRCL G
Sbjct: 1209 FKCSCPPGTRGLLCEENID---DC-ARGPHCLNGGQCMDRIGGYSCRCLPG 1255
Score = 509 bits (1311), Expect = e-144
Identities = 296/950 (31%), Positives = 418/950 (44%), Gaps = 210/950 (22%)
Query: 222 TCDQYGNK---ACMDGWMGKECKEAV--CKQGCNLLHGGC--TVPG--ECRCSYGWQGRF 272
TC N+ C+ G+ G++C+ V C + HGG +PG +C+C G+ G++
Sbjct: 158 TCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQY 217
Query: 273 CDE----CVPYPGCVHGSCVEP----WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI 324
CD C P P G+C + ++CNC + G C+++++ C +H C NGG C+
Sbjct: 218 CDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHR-CQNGGVCV 276
Query: 325 NAEPDQYRCTCPDGYSGRNCEKAEHACTSNP--CANGGSCHEVPSGFECHCPSGWSGPTC 382
+ + Y C CP ++G+ C + C P C NGG+C G+ C C +GWSG C
Sbjct: 277 DGV-NTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Query: 383 ALDIDECASNPCAAGGTCVDQVDGFECICPE----------------------------- 413
+ +ID+CA C G TC+D+V F C+CPE
Sbjct: 336 SENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPL 395
Query: 414 --QWV--------GATCQLDANEC---EGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI 460
Q++ GA C D +EC PC +A C N G ++C+C+ G+ G C +
Sbjct: 396 NGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEM 455
Query: 461 NVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADG 519
++N+C CQ+ TC D + G+ C+C GF G HCELE +EC S+PC + G C D +
Sbjct: 456 DINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNR 515
Query: 520 FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC-----SVP 574
F C CP GF+GP+C++D+D C +PC NGA+C + Y C C F G C +
Sbjct: 516 FQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCD 575
Query: 575 REPCPGGACR-VIDGCGSDAGPGMPGTAA--------SGVCGPHGRCVS---------QP 616
+PC G C+ ID PG G S C GRC+ QP
Sbjct: 576 PDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQP 635
Query: 617 G---------------------------GNFSCICDSGFTGTYCHENIDDCLGQPCRNGG 649
G +SC+C GFTG C+ +ID+C PCR G
Sbjct: 636 GTSGVNCEINFDDCASNPCIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGA 695
Query: 650 TCIDEVDAFRCFCP-------------------------------------SGWEGELCD 672
TCI+ V+ FRC CP +GW G C+
Sbjct: 696 TCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWVGINCE 755
Query: 673 TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYD--S 730
+ N+CL +PC + G C +LVN + C C G+KG C +C + C N GTC+D S
Sbjct: 756 VDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDIS 815
Query: 731 G--------------------------------------DTFRCACPPGWKGSTCAVAKN 752
G +++ C C PGW+G C +
Sbjct: 816 GYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTI-DI 874
Query: 753 SSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFR 812
C+ PC+N G C + S+ C C G+ G C + +DC PC NGG C+DGVN F
Sbjct: 875 DECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFS 934
Query: 813 CECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGR 870
C C PGF G C+ +++EC S PC G TC D +N Y C C G G C+ I
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINECTES 994
Query: 871 SCWSRGTPFPHGSSWVEDC----NSCRCLDGRRDCSKVWCGWKPCLLAGQ----PEALSA 922
SC++ GT +S+ C CL +CS PCL G
Sbjct: 995 SCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSS-----HPCLNEGTCVDGLGTYRC 1049
Query: 923 QCPLGQ--RCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
CPLG + + C R PC+ G C ++ + CL SG C
Sbjct: 1050 SCPLGYTGKNCQTLVNLCSRSPCKNKGTC-VQKKAESQCLCPSGWAGAYC 1098
Score = 460 bits (1184), Expect = e-129
Identities = 261/792 (32%), Positives = 362/792 (45%), Gaps = 120/792 (15%)
Query: 231 CMDGWMGKECKEAVCKQG-CNLLHGGCTVPGECRCSYGWQGRFC--------DECVPYPG 281
C DG+ E +G C H G G C+C G+ G +C + C
Sbjct: 28 CRDGY------EPCVNEGMCVTYHNGT---GYCKCPEGFLGEYCQHRDPCEKNRCQNGGT 78
Query: 282 CVHGSCVEPWQCNCETNWGGLLCDKDLNY-CGSHHPCTNGGTCINAEPDQYRCTCPDGYS 340
CV + + C C + + G C ++ C PC NGGTC D Y CTC G++
Sbjct: 79 CVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFT 138
Query: 341 GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE------------ 388
G+ C+ + AC S+PCANG +C V + F C C +G++G C D++E
Sbjct: 139 GKECQWTD-ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGT 197
Query: 389 ---------------------------CASNPCAAGGTCVDQVD-GFECICPEQWVGATC 420
CA +PC GGTC D FEC C + G+TC
Sbjct: 198 CLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTC 257
Query: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ---CQHGGTCKD 477
+ + ++C C N C + + Y C C P W G C +V++C Q CQ+GGTC +
Sbjct: 258 ERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCAN 317
Query: 478 LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV 537
GY CVC G+ G C D+CA + C G C D F C CP+G +G LC +D
Sbjct: 318 RNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLD- 376
Query: 538 DLCEPSPCRNGARCYN--LEGDYYCACPDDFGGKNCSVPREPCP---------GGACRVI 586
D C +PC GA C L G Y C CP + G +C+ + C G C
Sbjct: 377 DACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNT 436
Query: 587 DG---CGSDAGPGMP------GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENI 637
DG C G P S C C+ + GG F+C+C GF G +C I
Sbjct: 437 DGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGG-FTCLCMPGFKGVHCELEI 495
Query: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
++C PC N G C+D+V+ F+C CP G+ G +C + +DC PC + +C D N +
Sbjct: 496 NECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYE 555
Query: 698 CACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP 757
C C G+ G C CD C + G C D D++ C C PG+ G+ C+ + C
Sbjct: 556 CQCATGFTGVLCEENIDNCDPDPCHH-GQCQDGIDSYTCICNPGYMGAICS-DQIDECYS 613
Query: 758 NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAP 817
+PC+N G C+ + C C+ G G C N +DC PC + GIC+DG+N + C C+P
Sbjct: 614 SPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCIH-GICMDGINRYSCVCSP 672
Query: 818 GFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGT 877
GF G C I+IDEC S+PC GATC++ +NG+RC CP G P C
Sbjct: 673 GFTGQRCNIDIDECASNPCRKGATCINGVNGFRCICPEGPHHPSCY-------------- 718
Query: 878 PFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQ 937
S V +C S C+ G +C+ G+K AG +G C E +
Sbjct: 719 ------SQVNECLSNPCIHG--NCTGGLSGYKCLCDAGW---------VGINC-EVDKNE 760
Query: 938 CLRPPCEAWGEC 949
CL PC+ G C
Sbjct: 761 CLSNPCQNGGTC 772
Score = 201 bits (512), Expect = 3e-51
Identities = 122/368 (33%), Positives = 163/368 (44%), Gaps = 32/368 (8%)
Query: 606 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE--VDAFRCFCP 663
C G CV+ G C C GF G YC D C C+NGGTC+ + + C C
Sbjct: 35 CVNEGMCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCA 93
Query: 664 SGWEGELCD-TNPNDCLPD-PCHSRGRCYDLVNDFY-CACDDGWKGKTCHSREFQCDAYT 720
SG+ GE C + + C PC + G C+ L D Y C C G+ GK C + C ++
Sbjct: 94 SGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHP 152
Query: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
C+NG TC + F C C G+ G C N +P C +GGTC+ S+ C C G
Sbjct: 153 CANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQG 212
Query: 781 WEGRTCTHNTNDCNPLPCYNGGIC-VDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYG 839
+ G+ C C P PC NGG C G F C C PGF G C NID+C + C G
Sbjct: 213 FTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNG 272
Query: 840 ATCVDEINGYRCSCPPGRAGPRCQEVIG----FGRSCWSRGTPFPHGSSWVEDCNSCRCL 895
CVD +N Y C CPP G C E + +C + GT + C C+
Sbjct: 273 GVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGY-----GCVCV 327
Query: 896 DG--RRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEK-APGQCLRPPCEAWGECGAE 952
+G DCS+ + A C G C+++ A C+ P +A C +
Sbjct: 328 NGWSGDDCSE-----------NIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLD 376
Query: 953 EP-PSTPC 959
+ S PC
Sbjct: 377 DACISNPC 384
Score = 135 bits (340), Expect = 2e-31
Identities = 103/356 (28%), Positives = 146/356 (41%), Gaps = 62/356 (17%)
Query: 203 YSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--CK-QGCNLLHGGCTVP 259
+ ATC+ DF G Y C+ C+ G+ G C+ V C+ Q C +GG +
Sbjct: 1160 HGATCS-------DFIGGYRCE------CVPGYQGVNCEYEVDECQNQPCQ--NGGTCID 1204
Query: 260 ----GECRCSYGWQGRFC----DECVPYPGCVHGS-CVEP---WQCNCETNWGGLLCDKD 307
+C C G +G C D+C P C++G C++ + C C + G C+ D
Sbjct: 1205 LVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGD 1264
Query: 308 LNYCGSHHPCTNGGT--CINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC--- 362
+N C S+ PC++ G+ CI D Y C C ++GR+CE C PC NGG+C
Sbjct: 1265 INECLSN-PCSSEGSLDCIQLTND-YLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVA 1322
Query: 363 HEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQL 422
+P GF C CP G+SG C C C G CV G C CP C+
Sbjct: 1323 SNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTASGPRCFCPSP---RDCE- 1375
Query: 423 DANECEGKPCLNAFSC--KNLIGGYYCDCIPGWKGINCHINV-------NDCRGQC---- 469
+ C PC + SC + Y C C P + G C + C Q
Sbjct: 1376 --SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADK 1433
Query: 470 QHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS-PC--HSGGLCEDLADGFHC 522
G C + N + C G E C+S PC + C++L + C
Sbjct: 1434 ARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVEC 1489
Score = 42.0 bits (97), Expect = 0.004
Identities = 62/274 (22%), Positives = 81/274 (29%), Gaps = 113/274 (41%)
Query: 219 GHYTCDQYGNK---ACMDGWMGKECKEAV--CKQGCNLLHGGCTVPGE------CRCSYG 267
G C Q N C + G+ C+ V C Q L G C V CRC G
Sbjct: 1277 GSLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPG 1336
Query: 268 WQGRFCD------ECVPYPGCVHGS----CVEPWQCNCETNWGGLLCDKDLNYCGSHHPC 317
+ G C +C CVH + C P +CE+ C S PC
Sbjct: 1337 FSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESG------------CASS-PC 1383
Query: 318 TNGGTCI-NAEPDQYRCTCPDGYSGRNCEK-------------------------AEHAC 351
+GG+C +P Y C C +SG CE + AC
Sbjct: 1384 QHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDGVCDEAC 1443
Query: 352 TSNPCA-NGGSCH---EVP-----------------------------SGFEC------- 371
S+ C +GG C E P FEC
Sbjct: 1444 NSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGNSKTC 1503
Query: 372 -------------HCPSGWSGPTCALDIDECASN 392
HC G + C D +CA++
Sbjct: 1504 KYDKYCADHFKDNHCDQGCNSEECGWDGLDCAAD 1537
Score = 31.2 bits (69), Expect = 6.4
Identities = 21/74 (28%), Positives = 30/74 (40%), Gaps = 14/74 (18%)
Query: 201 NYYSATCNKFCRPRNDFFGHYTCDQYGNKACM-DGWMGKECKEAVCKQGCNLLHGGCTVP 259
+Y + C++ C F ++ C Q +K C D + K+ C QGCN
Sbjct: 1474 DYINNQCDELCNTVECLFDNFEC-QGNSKTCKYDKYCADHFKDNHCDQGCN--------S 1524
Query: 260 GECRCSYGWQGRFC 273
EC GW G C
Sbjct: 1525 EEC----GWDGLDC 1534
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 491 bits (1263), Expect = e-138
Identities = 277/813 (34%), Positives = 368/813 (45%), Gaps = 106/813 (13%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC---DECVPYPGC 282
C++GW G+ C + + + G T C C G G C D CV P
Sbjct: 302 CVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCH 361
Query: 283 VHGSC-VEPWQ----CNCETNWGGLLCDKDLNYCG-SHHPCTNGGTCINAEPDQYRCTCP 336
C P C C + G CD+D++ C +PC + G C+N + + C C
Sbjct: 362 EDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQ-GSFLCQCG 420
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396
GY+G CE + C S PC N +C + F C C +G++G C +DIDEC S+PC
Sbjct: 421 RGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVN 480
Query: 397 GGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGI 456
GG C D+V+GF C CP + G+TCQLD +EC PC N C + GY C C G++G
Sbjct: 481 GGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGT 540
Query: 457 NCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDL 516
C NV+DC H G C D + + C C G+ G CE + DEC S PC GG C DL
Sbjct: 541 LCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDL 600
Query: 517 ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE 576
D + C CP G +G CEV++D C +PC G C + Y C C F G C+V
Sbjct: 601 VDKYLCRCPSGTTGVNCEVNIDDCASNPCTFGV-CRDGINRYDCVCQPGFTGPLCNVEIN 659
Query: 577 PC------PGGACRVIDG-------CGSDAGPGM---PGTAASGVCGPHGRCVSQPGGNF 620
C GG+C +DG C + P + P + HG C PGG F
Sbjct: 660 ECASSPCGEGGSC--VDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGG-F 716
Query: 621 SCICDSGFTGTYCHENI--DDCLGQPCRNGGTCIDEVDAFR------------------- 659
C+C+ G++G C +++ D C QPCR GGTC + F
Sbjct: 717 RCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCT 776
Query: 660 -------------------CFCPSGWEGELCDTNPNDCL-PDPCHSRGRCYDLVNDFYCA 699
C CP GW+G C + ++C P PC G C +L F C
Sbjct: 777 PNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCT 836
Query: 700 CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNP 759
C G+ G +C CD C NGG+C D +F C+C PG+ G CA CL NP
Sbjct: 837 CHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCA-RDVDECLSNP 895
Query: 760 CVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF 819
C GTC ASF+C C G+ G C + DC+P C+NGG CVDGVN F C C PG+
Sbjct: 896 C-GPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGY 954
Query: 820 AGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPF 879
G C+ D C S PC +G C G+RC+C GP+CQ ++ W P
Sbjct: 955 TGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVD-----WCSRQPC 1009
Query: 880 PHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAP--GQ 937
+G V+ C C G W G + C + P C E A G
Sbjct: 1010 QNGGRCVQTGAYCLCPPG-------WSG-RLCDIRSLP------------CREAAAQIGV 1049
Query: 938 CLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
L C+A G+C +E S C+ G ++C
Sbjct: 1050 RLEQLCQAGGQC-VDEDSSHYCVCPEGRTGSHC 1081
Score = 477 bits (1228), Expect = e-134
Identities = 266/775 (34%), Positives = 359/775 (46%), Gaps = 71/775 (9%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGG-CTVPGE----CRCSYGWQGRFC----DECVPYPG 281
C G+ G +C HG C+V + C C G+QGR C DEC
Sbjct: 108 CPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEP 167
Query: 282 CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337
C HG +C+ ++C C + G LC+ C PC NGGTC + Y C C
Sbjct: 168 CRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPS-PCRNGGTCRQSGDLTYDCACLP 226
Query: 338 GYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP--CA 395
G+ G+NCE C + C NGG+C + + + C CP W+G C D+DEC P C
Sbjct: 227 GFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACH 286
Query: 396 AGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKG 455
GGTC + + G C+C W G +C + ++C C + +C + + +YC C G G
Sbjct: 287 NGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTG 346
Query: 456 INCHINVNDCRGQCQHGGTC-KDLVNGYQ-CVCPRGFGGRHCELERDECA--SSPCHSGG 511
+ CH++ C C + VNG C CP GF G C+ + DEC+ ++PC G
Sbjct: 347 LLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANPCEHLG 406
Query: 512 LCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
C + F C C +G++GP CE DV+ C PCRN A C + G + C C F G C
Sbjct: 407 RCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAGFTGTYC 466
Query: 572 SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGT 631
V + C C ++G G C + G FSC C SGF+G+
Sbjct: 467 EVDIDECQSSPC--VNG---------------------GVCKDRVNG-FSCTCPSGFSGS 502
Query: 632 YCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 691
C ++D+C PCRNG C+D+ D + C C G+EG LCD N +DC PDPCH GRC D
Sbjct: 503 TCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCH-HGRCVD 561
Query: 692 LVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAK 751
+ F CAC G+ G C S+ +C + C +GG C D D + C CP G G C V
Sbjct: 562 GIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV-N 620
Query: 752 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 811
C NPC G C + C+C+ G+ G C N+C PC GG CVDG N F
Sbjct: 621 IDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGEGGSCVDGENGF 679
Query: 812 RCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG---- 867
RC C PG P C C PC++G C D G+RC C PG +GPRC + +
Sbjct: 680 RCLCPPGSLPPLCLPPSHPCAHEPCSHG-ICYDAPGGFRCVCEPGWSGPRCSQSLARDAC 738
Query: 868 FGRSCWSRGTPFPHGSSWVEDCNSCRCLDG--RRDCSKVW-CGWKPCLLAGQPEALSAQC 924
+ C + GT G + C C G R C + C PC G+ E+ Q
Sbjct: 739 ESQPCRAGGTCSSDGMGF-----HCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQL 793
Query: 925 PL--------GQRCLEKAPGQCLRP-PCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
P+ G RC ++ +C P PC G C S C G+ +C
Sbjct: 794 PVCSCPQGWQGPRC-QQDVDECAGPAPCGPHGIC-TNLAGSFSCTCHGGYTGPSC 846
Score = 470 bits (1210), Expect = e-132
Identities = 270/795 (33%), Positives = 363/795 (45%), Gaps = 92/795 (11%)
Query: 231 CMDGWMGK-------ECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCD----ECVPY 279
C G+ G EC C+ G + ECRC+ G++G CD +C P
Sbjct: 495 CPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGY--ECRCAEGFEGTLCDRNVDDCSPD 552
Query: 280 PGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
P C HG CV+ + C C + G C+ ++ C S PC +GG C++ D+Y C CP
Sbjct: 553 P-CHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQ-PCRHGGKCLDLV-DKYLCRCP 609
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAA 396
G +G NCE C SNPC G C + + ++C C G++GP C ++I+ECAS+PC
Sbjct: 610 SGTTGVNCEVNIDDCASNPCTFG-VCRDGINRYDCVCQPGFTGPLCNVEINECASSPCGE 668
Query: 397 GGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGI 456
GG+CVD +GF C+CP + C ++ C +PC + C + GG+ C C PGW G
Sbjct: 669 GGSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGI-CYDAPGGFRCVCEPGWSGP 727
Query: 457 NCHINV--NDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC 513
C ++ + C Q C+ GGTC G+ C CP G GR CEL C +PC GG C
Sbjct: 728 RCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCEL-LSPCTPNPCEHGGRC 786
Query: 514 EDLADGFH-CHCPQGFSGPLCEVDVDLCE-PSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
E C CPQG+ GP C+ DVD C P+PC C NL G + C C + G +C
Sbjct: 787 ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSC 846
Query: 572 SVPREPCP------GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG------- 618
C GG+C+ DG GS + +PG A C+S P G
Sbjct: 847 DQDINDCDPNPCLNGGSCQ--DGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDH 904
Query: 619 --NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPN 676
+F+C C G+ G +C +++ DC C NGGTC+D V++F C C G+ G C +
Sbjct: 905 VASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEAD 964
Query: 677 DCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 736
CL PC G C F C C + + G C + C C NGG C +G C
Sbjct: 965 PCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAY--C 1022
Query: 737 ACPPGWKGSTC---------AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCT 787
CPPGW G C A A+ L C GG CV +S C+C +G G C
Sbjct: 1023 LCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCE 1082
Query: 788 HNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEIN 847
+ C PC +GG C + + CEC PG+ G +C ++DEC S PC +G +C+D +
Sbjct: 1083 QEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVA 1142
Query: 848 GYRCSCPPGRAGPRCQ---------EVIGFGRSCWSRGT-------------PFPHGSSW 885
Y CSCPPG G C+ + G C GT P G
Sbjct: 1143 RYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRC 1202
Query: 886 VEDCNSCRC----LDGRRDCSKVWCGWKPCLL-AGQPEALSAQCPLGQRCLEKAPGQCLR 940
D N CR RDC + G CL AG G RC + C
Sbjct: 1203 EADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFS---------GPRC-QTVLSPCES 1252
Query: 941 PPCEAWGECGAEEPP 955
PC+ G+C P
Sbjct: 1253 QPCQHGGQCRPSPGP 1267
Score = 452 bits (1164), Expect = e-127
Identities = 272/852 (31%), Positives = 363/852 (42%), Gaps = 147/852 (17%)
Query: 196 VRCDENYYSATCNK----FCRPRNDFFGHYTCDQYGNKACMDGWMG-------KECKEAV 244
V C+ N N CR D Y C C G+ G EC +
Sbjct: 615 VNCEVNIDDCASNPCTFGVCR---DGINRYDC------VCQPGFTGPLCNVEINECASSP 665
Query: 245 CKQGCNLLHGGCTVPGE----CRCSYGWQGRFC----DECVPYPGCVHGSCVEP---WQC 293
C +G G V GE C C G C C P C HG C + ++C
Sbjct: 666 CGEG------GSCVDGENGFRCLCPPGSLPPLCLPPSHPCAHEP-CSHGICYDAPGGFRC 718
Query: 294 NCETNWGGLLCDKDL--NYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC 351
CE W G C + L + C S PC GGTC +++ + CTCP G GR CE C
Sbjct: 719 VCEPGWSGPRCSQSLARDACESQ-PCRAGGTC-SSDGMGFHCTCPPGVQGRQCELLS-PC 775
Query: 352 TSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCALDIDECASN-PCAAGGTCVDQVDGFEC 409
T NPC +GG C P C CP GW GP C D+DECA PC G C + F C
Sbjct: 776 TPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
Query: 410 ICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ- 468
C + G +C D N+C+ PCLN SC++ +G + C C+PG+ G C +V++C
Sbjct: 836 TCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP 895
Query: 469 -------------------------------------CQHGGTCKDLVNGYQCVCPRGFG 491
C +GGTC D VN + C+C G+
Sbjct: 896 CGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYT 955
Query: 492 GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARC 551
G HC+ E D C S PC GG+C GF C C + F+GP C+ VD C PC+NG RC
Sbjct: 956 GAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC 1015
Query: 552 YNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 611
++ YC CP + G+ C + PC A ++ G +C G+
Sbjct: 1016 --VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQI-------------GVRLEQLCQAGGQ 1060
Query: 612 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671
CV + ++ C+C G TG++C + +D CL QPC++GGTC + + C C G+ G+ C
Sbjct: 1061 CVDEDSSHY-CVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNC 1119
Query: 672 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC-------DAYTCSNG 724
+ + ++C PC G C DLV + C+C G G C E C C +
Sbjct: 1120 EDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHN 1179
Query: 725 GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGT--CVGS-GASFSCICRDGW 781
GTC D FRC CPPG+ G C N C C T C+ G F C+C G+
Sbjct: 1180 GTCVDLVGGFRCTCPPGYTGLRCEADINE-CRSGACHAAHTRDCLQDPGGGFRCLCHAGF 1238
Query: 782 EGRTCTHNTNDCNPLPCYNGGIC-----VDGVNWFRCECAPGFAGPDCRINIDECQSSPC 836
G C + C PC +GG C G F C CA F GP C C+ C
Sbjct: 1239 SGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQC 1298
Query: 837 AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLD 896
G C G RC+CPPG +GP C+ G P G+S C + CL
Sbjct: 1299 PVGVPCQQTPRGPRCACPPGLSGPSCRSFPG-----------SPPGAS-NASCAAAPCLH 1346
Query: 897 G------------RRDCSKVWCGWKPCLLAGQPE-ALSAQCP----LGQRCLEKAPGQCL 939
G R C++ W G + A PE + +CP +R ++ +C
Sbjct: 1347 GGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECN 1406
Query: 940 RPPCEAW--GEC 949
P C W G+C
Sbjct: 1407 SPGC-GWDGGDC 1417
Score = 444 bits (1141), Expect = e-124
Identities = 243/720 (33%), Positives = 329/720 (45%), Gaps = 88/720 (12%)
Query: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAE---------------------- 348
C PC NGG C + C CP G+ G C+ +
Sbjct: 43 CLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTA 102
Query: 349 ------------------HACTSNPCANGGSCHEVPSG-FECHCPSGWSGPTCALDIDEC 389
C S+PCA+G C P G F C CP G+ G +C D+DEC
Sbjct: 103 RFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDEC 162
Query: 390 -ASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIG-GYYC 447
PC GGTC++ F C CP + G C+ A C PC N +C+ Y C
Sbjct: 163 RVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGDLTYDC 222
Query: 448 DCIPGWKGINCHINVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP 506
C+PG++G NC +NV+DC G +C +GGTC D VN Y C CP + G+ C + DEC P
Sbjct: 223 ACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQP 282
Query: 507 --CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564
CH+GG C + G C C G++G C ++D C + C +GA C++ +YCACP
Sbjct: 283 NACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPM 342
Query: 565 DFGGKNCSVPREPCPGGACRVIDGCGSD---------AGPGMPGTA----------ASGV 605
G C + + C C C ++ PG G A +
Sbjct: 343 GKTGLLCHLD-DACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANP 401
Query: 606 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 665
C GRCV+ G+F C C G+TG C ++++CL PCRN TC+D + F C C +G
Sbjct: 402 CEHLGRCVNTQ-GSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTCICMAG 460
Query: 666 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGG 725
+ G C+ + ++C PC + G C D VN F C C G+ G TC +C + C NG
Sbjct: 461 FTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGA 520
Query: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRT 785
C D D + C C G++G+ C C P+PC + G CV ASFSC C G+ G
Sbjct: 521 KCVDQPDGYECRCAEGFEGTLCD-RNVDDCSPDPC-HHGRCVDGIASFSCACAPGYTGTR 578
Query: 786 CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDE 845
C ++C PC +GG C+D V+ + C C G G +C +NID+C S+PC +G C D
Sbjct: 579 CESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCRDG 637
Query: 846 INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVW 905
IN Y C C PG GP C I C S +P G S V+ N RCL +
Sbjct: 638 INRYDCVCQPGFTGPLCNVEI---NECAS--SPCGEGGSCVDGENGFRCLCPPGSLPPLC 692
Query: 906 ------CGWKPC---LLAGQPEALSAQCP---LGQRCLEK-APGQCLRPPCEAWGECGAE 952
C +PC + P C G RC + A C PC A G C ++
Sbjct: 693 LPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSD 752
Score = 372 bits (956), Expect = e-103
Identities = 251/822 (30%), Positives = 330/822 (40%), Gaps = 160/822 (19%)
Query: 231 CMDGWMGKECKEAVCKQGCNL----LHGGCTVPG---ECRCSYGWQGRFCD---ECVPYP 280
C GW G C +++ + C G C+ G C C G QGR C+ C P P
Sbjct: 720 CEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNP 779
Query: 281 GCVHGSCVE--PWQ---CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTC 335
C HG E P Q C+C W G C +D++ C PC G C N + CTC
Sbjct: 780 -CEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLA-GSFSCTC 837
Query: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395
GY+G +C++ + C NPC NGGSC + F C C G++GP CA D+DEC SNPC
Sbjct: 838 HGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCG 897
Query: 396 AG-------------------------------------GTCVDQVDGFECICPEQWVGA 418
G GTCVD V+ F C+C + GA
Sbjct: 898 PGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGA 957
Query: 419 TCQLDANECEGKPCLNAF--------------------SCKNLIG--------------- 443
CQ +A+ C +PCL+ C+ L+
Sbjct: 958 HCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQ 1017
Query: 444 -GYYCDCIPGWKGINCHINVNDCRGQ-----------CQHGGTCKDLVNGYQCVCPRGFG 491
G YC C PGW G C I CR CQ GG C D + + CVCP G
Sbjct: 1018 TGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRT 1077
Query: 492 GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARC 551
G HCE E D C + PC GG C G+ C C G++G CE DVD C PC++G C
Sbjct: 1078 GSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECASQPCQHGGSC 1137
Query: 552 YNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGR 611
+L Y C+CP G C + + C GPG P + C +G
Sbjct: 1138 IDLVARYLCSCPPGTLGVLCEINEDDC---------------GPG-PPLDSGPRCLHNGT 1181
Query: 612 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT--CI-DEVDAFRCFCPSGWEG 668
CV GG F C C G+TG C +I++C C T C+ D FRC C +G+ G
Sbjct: 1182 CVDLVGG-FRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSG 1240
Query: 669 ELCDTNPNDCLPDPCHSRGRCYDLVN-----DFYCACDDGWKGKTCHSREFQCDAYTCSN 723
C T + C PC G+C F C C + G C C C
Sbjct: 1241 PRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPV 1300
Query: 724 GGTCYDSGDTFRCACPPGWKGSTCAV-------AKNSSCLPNPCVNGGTCVGSGAS--FS 774
G C + RCACPPG G +C A N+SC PC++GG+C + + F
Sbjct: 1301 GVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR 1360
Query: 775 CICRDGWEGRTC--THNTNDCNPLPCYNGGICVDGVNWFRC--EC---APGFAGPDCRIN 827
C C GW G C + + P C RC EC G+ G DC ++
Sbjct: 1361 CACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLS 1420
Query: 828 ID----ECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+ +C++ C N RC P + P C + C + G
Sbjct: 1421 VGDPWRQCEA------LQCWRLFNNSRCD--PACSSPAC---LYDNFDCHAGGRERTCNP 1469
Query: 884 SWVEDCNSCRCLDGRRD--CSKVWCGWKPCLLAGQPEALSAQ 923
+ + C + DGR D C+ CGW A + AL A+
Sbjct: 1470 VYEKYC-ADHFADGRCDQGCNTEECGWDGLDCASEVPALLAR 1510
Score = 207 bits (527), Expect = 5e-53
Identities = 110/287 (38%), Positives = 143/287 (49%), Gaps = 18/287 (6%)
Query: 593 AGPGM--PGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGT 650
AGPG P C GRC P +C+C G+ G C D C PC G
Sbjct: 34 AGPGAAAPPCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQLE-DPCHSGPCAGRGV 92
Query: 651 CIDEVDA----FRCFCPSGWEGELCDTNPNDCLPDPCHSRGRC-YDLVNDFYCACDDGWK 705
C V A F C CP G+ G C P+ CL PC RC F C+C G++
Sbjct: 93 CQSSVVAGTARFSCRCPRGFRGPDCSL-PDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQ 151
Query: 706 GKTCHSREFQCD-AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS--CLPNPCVN 762
G++C S +C C +GGTC ++ +FRC CP G+ G C +N + C P+PC N
Sbjct: 152 GRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLC---ENPAVPCAPSPCRN 208
Query: 763 GGTCVGSG-ASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAG 821
GGTC SG ++ C C G+EG+ C N +DC C NGG CVDGVN + C+C P + G
Sbjct: 209 GGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTG 268
Query: 822 PDCRINIDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
C ++DECQ P C G TC + + G+ C C G G C + I
Sbjct: 269 QFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI 315
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 481 bits (1238), Expect = e-135
Identities = 223/523 (42%), Positives = 284/523 (54%), Gaps = 24/523 (4%)
Query: 28 GYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRVCLKEYQAKVTPTGP 87
G FEL+L N G L + CC G G C T+ RVCLK YQA V+P P
Sbjct: 23 GVFELKLQEFVNKKGLLGNRNCCRG------GAGPPPCACRTFFRVCLKHYQASVSPEPP 76
Query: 88 CSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIPFQFAWPRSFTLIVE 147
C+YG TPVLG +SF LP G A R PF F WP +F+LI+E
Sbjct: 77 CTYGSAVTPVLGVDSFSLPDGGGADSAFSNPIR-----------FPFGFTWPGTFSLIIE 125
Query: 148 AWDWDND---TTPNEELLIERVSHAGMINPEDRW-KSLHFSGHVAHLELQIRVRCDENYY 203
A D+ T N E LI R++ + + W + LH SG L+ R CDE+YY
Sbjct: 126 ALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRT-DLKYSYRFVCDEHYY 184
Query: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263
C+ FCRPR+D FGH+TC + G K C GW G C E +C GC+ HG C PGEC+
Sbjct: 185 GEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECK 244
Query: 264 CSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTC 323
C GWQGR+CDEC+ YPGC+HG+C +PWQCNC+ WGGL C++DLNYC H PC NG TC
Sbjct: 245 CRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATC 304
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383
N Y C+C GY+G CE C +PC NGGSC ++ + + C CP G+ G C
Sbjct: 305 TNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPGFYGKICE 364
Query: 384 LDIDECASNPCAAGGTCVDQVD-GFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLI 442
L CA PC GG C D D G+ C CP + G C+ + C PC N C +L
Sbjct: 365 LSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLG 424
Query: 443 GGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE 501
Y C C G+ G +C NV+DC C +GGTC+D VN + C CP G+ GR+C
Sbjct: 425 DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSR 484
Query: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP 544
C +PCH+G C + + C C +G+ GP C+ + P P
Sbjct: 485 CEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGP 527
Score = 232 bits (592), Expect = 1e-60
Identities = 137/422 (32%), Positives = 179/422 (42%), Gaps = 85/422 (20%)
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGG-SCHEVPSGFECHCPSGWSGPTCALDIDEC 389
YR C + Y G C C A G +C E E C GW GP C I
Sbjct: 175 YRFVCDEHYYGEGCSVF---CRPRDDAFGHFTCGERG---EKVCNPGWKGPYCTEPI--- 225
Query: 390 ASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDC 449
C G D+ GF C P + C C
Sbjct: 226 ----CLPG---CDEQHGF-CDKPGE--------------------------------CKC 245
Query: 450 IPGWKGINCHINVNDCRGQ--CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS-SP 506
GW+G C ++C C HG TC+ +QC C G+GG C + + C P
Sbjct: 246 RVGWQGRYC----DECIRYPGCLHG-TCQQ---PWQCNCQEGWGGLFCNQDLNYCTHHKP 297
Query: 507 CHSGGLCEDLADG-FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
C +G C + G + C C G++G CE+ +D C+PSPC+NG C +LE Y C CP
Sbjct: 298 CKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSYSCTCPPG 357
Query: 566 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 625
F GK C + C A G C GRC P G +SC C
Sbjct: 358 FYGKICELSAMTC-----------------------ADGPCFNGGRCSDSPDGGYSCRCP 394
Query: 626 SGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS 685
G++G C + ID C PC NG C+D DA+ C C +G+ G CD N +DC PC +
Sbjct: 395 VGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCAN 454
Query: 686 RGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGS 745
G C D VNDF C C G+ G+ C + +C+ C NG TC++ G + C C G+ G
Sbjct: 455 GGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGP 514
Query: 746 TC 747
C
Sbjct: 515 NC 516
Score = 228 bits (581), Expect = 3e-59
Identities = 141/453 (31%), Positives = 190/453 (41%), Gaps = 77/453 (16%)
Query: 459 HINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 518
H+ V + Q H DL Y+ VC + G C + C D
Sbjct: 152 HLTVGEEWSQDLHSSGRTDLKYSYRFVCDEHYYGEGCSV--------------FCRPRDD 197
Query: 519 GF-HCHCPQ--------GFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGK 569
F H C + G+ GP C + C P C + G+ C C + G+
Sbjct: 198 AFGHFTCGERGEKVCNPGWKGPYCTEPI--CLPGCDEQHGFC-DKPGE--CKCRVGWQGR 252
Query: 570 NCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT 629
C C GC HG C QP + C C G+
Sbjct: 253 YCD---------ECIRYPGC------------------LHGTC-QQP---WQCNCQEGWG 281
Query: 630 GTYCHENIDDCLG-QPCRNGGTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 687
G +C+++++ C +PC+NG TC + ++ C C G+ G C+ ++C P PC + G
Sbjct: 282 GLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGG 341
Query: 688 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT-FRCACPPGWKGST 746
C DL N + C C G+ GK C C C NGG C DS D + C CP G+ G
Sbjct: 342 SCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFN 401
Query: 747 CAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD 806
C K C +PC NG CV G ++ C C+ G+ GR C N +DC PC NGG C D
Sbjct: 402 CE-KKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRD 460
Query: 807 GVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ--- 863
GVN F C C PG+ G +C + C+ +PC GATC + + Y C C G GP CQ
Sbjct: 461 GVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLL 520
Query: 864 -------EVIGFGRSCWSRGTPFPHGSSWVEDC 889
V+ +G PFP WV C
Sbjct: 521 PELPPGPAVVDLTEKLEGQGGPFP----WVAVC 549
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 479 bits (1232), Expect = e-135
Identities = 236/550 (42%), Positives = 302/550 (54%), Gaps = 38/550 (6%)
Query: 1 MRAQGRGRLPRRLLLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAG 60
M A R LLLL+ALW Q A G F+LQL N G L SG C+
Sbjct: 1 MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG------- 53
Query: 61 GCGHDECDTYVRVCLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARAR 120
C T+ RVCLK +QA V+P GPC++G +TPVLG NSF A D +
Sbjct: 54 ------CRTFFRVCLKHFQAVVSP-GPCTFGTVSTPVLGTNSF------AVRDDS----- 95
Query: 121 AGGDQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPNEEL----LIERVSHAGMINPED 176
+GG ++P + +PF F WP +F+LI+EAW D E L LI +++ G +
Sbjct: 96 SGGGRNP--LQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQ 153
Query: 177 RWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWM 236
W + + L RV C +NYY C++ C+ RND FGHY C GN +C+ GW
Sbjct: 154 NWLLDEQTSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWT 213
Query: 237 GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE 296
G+ C++ +C GC+ +G C+ P EC C GWQGR C+EC+P+ GC HG+C PWQC C+
Sbjct: 214 GEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCD 273
Query: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
WGGL CD+DLNYC H PC NG TC N+ Y CTC GY+G +CE C SNPC
Sbjct: 274 EGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPC 333
Query: 357 ANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG--FECICPEQ 414
NGGSC + G+ C CP G+ G C CA +PC GG+C ++ G + C CP
Sbjct: 334 RNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPN 393
Query: 415 WVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-RGQCQHGG 473
+ G+ C+ + C PC N C N C C PG+ G C ++V+DC R C HGG
Sbjct: 394 FTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGG 453
Query: 474 TCKDLVNGYQCVCPRGFGGRHCELER--DECASSPCHSGGLC-EDLA-DGFHCHCPQGFS 529
TC DL NG C CP GF GR CE+ D CASSPC + C DL+ D F C+CP GF
Sbjct: 454 TCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
Query: 530 GPLCEVDVDL 539
G CE V L
Sbjct: 514 GSRCEFPVGL 523
Score = 205 bits (521), Expect = 2e-52
Identities = 135/433 (31%), Positives = 179/433 (41%), Gaps = 102/433 (23%)
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEV--PSGFECHCPSGWSGPTCALDIDE 388
YR C D Y G NC + C N H V P G C GW+G C I
Sbjct: 171 YRVICSDNYYGDNCSRL---CKKR---NDHFGHYVCQPDG-NLSCLPGWTGEYCQQPI-- 221
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCD 448
C +G C EQ N KP C
Sbjct: 222 -----CLSG-------------CHEQ----------NGYCSKPA-------------ECL 240
Query: 449 CIPGWKGINCHINVNDC--RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS-S 505
C PGW+G C N+C C+HG TC +QC C G+GG C+ + + C S
Sbjct: 241 CRPGWQGRLC----NECIPHNGCRHG-TCS---TPWQCTCDEGWGGLFCDQDLNYCTHHS 292
Query: 506 PCHSGGLCEDLAD-GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564
PC +G C + + C C G++G CE+++ C+ +PCRNG C + E Y+C CP
Sbjct: 293 PCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPP 352
Query: 565 DFGGKNC-----SVPREPC-PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618
+ G +C S PC GG+CR G
Sbjct: 353 GYYGLHCEHSTLSCADSPCFNGGSCRE----------------------------RNQGA 384
Query: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
N++C C FTG+ C + +D C PC NGG C++ + C C G+ G C+ + +DC
Sbjct: 385 NYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDC 444
Query: 679 LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF--QCDAYTCSNGGTCYD--SGDTF 734
+PC G C+DL N C C G+ G+ C R C + C N TCY S DTF
Sbjct: 445 ARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTF 504
Query: 735 RCACPPGWKGSTC 747
C CP G+ GS C
Sbjct: 505 VCNCPYGFVGSRC 517
Score = 203 bits (517), Expect = 7e-52
Identities = 125/399 (31%), Positives = 180/399 (45%), Gaps = 60/399 (15%)
Query: 482 YQCVCPRGFGGRHCELERDECASSPCHSGG-LCEDLADGFHCHCPQGFSGPLCEVDVDLC 540
Y+ +C + G +C C H G +C+ DG + C G++G C+ +
Sbjct: 171 YRVICSDNYYGDNCSRL---CKKRNDHFGHYVCQP--DG-NLSCLPGWTGEYCQQPI--- 221
Query: 541 EPSPCRNGARCYNLEG----DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 596
C +G C+ G C C + G+ C+ E P CR
Sbjct: 222 ----CLSG--CHEQNGYCSKPAECLCRPGWQGRLCN---ECIPHNGCR------------ 260
Query: 597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQ-PCRNGGTCIDEV 655
HG C S P + C CD G+ G +C ++++ C PC+NG TC +
Sbjct: 261 ------------HGTC-STP---WQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
Query: 656 D-AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 714
++ C C G+ G C+ ++C +PC + G C D + ++C C G+ G C
Sbjct: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
Query: 715 QCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 772
C C NGG+C + G + C CPP + GS C K C NPC NGG C+ G S
Sbjct: 365 SCADSPCFNGGSCRERNQGANYACECPPNFTGSNCE-KKVDRCTSNPCANGGQCLNRGPS 423
Query: 773 FSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC--RINIDE 830
C CR G+ G C + +DC PC +GG C D N C C GF+G C R +ID
Sbjct: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
Query: 831 CQSSPCAYGATCVDEING--YRCSCPPGRAGPRCQEVIG 867
C SSPC ATC +++ + C+CP G G RC+ +G
Sbjct: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPVG 522
Score = 95.5 bits (236), Expect = 3e-19
Identities = 68/262 (25%), Positives = 101/262 (38%), Gaps = 65/262 (24%)
Query: 198 CDENYYSATCNK---FCRPRNDFFGHYTCDQYGNKA----CMDGWMGKECKEAVCKQGCN 250
CDE + C++ +C + TC G ++ C G+ G +C+ + + N
Sbjct: 272 CDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSN 331
Query: 251 LLHGGCTVPGE-----CRCSYGWQGRFCDE----CVPYPGCVHGSCVEPWQ-----CNCE 296
G + + C C G+ G C+ C P GSC E Q C C
Sbjct: 332 PCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECP 391
Query: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
N+ G C+K ++ C S+ PC NGG C+N P + C C G++G CE C NPC
Sbjct: 392 PNFTGSNCEKKVDRCTSN-PCANGGQCLNRGPSRM-CRCRPGFTGTYCELHVSDCARNPC 449
Query: 357 ANGGSCHEVPSG------------------------------------------FECHCP 374
A+GG+CH++ +G F C+CP
Sbjct: 450 AHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCP 509
Query: 375 SGWSGPTCALDIDECASNPCAA 396
G+ G C + S P A
Sbjct: 510 YGFVGSRCEFPVGLPPSFPWVA 531
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 465 bits (1196), Expect = e-130
Identities = 285/879 (32%), Positives = 372/879 (42%), Gaps = 153/879 (17%)
Query: 231 CMDGWMGKECK---EAVCKQGCNLLHGGCTVPG----ECRCSYGWQGRFC---DECVPYP 280
C+ G+ G+ C+ E C G C + +C C GW G C D C P
Sbjct: 105 CLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANP 164
Query: 281 GCVHGS-CVEPW---QCNCETNWGGLLCDKDLNYCGSHH-PCTNGGTCINAEPDQYRCTC 335
CV+G C+ + QC+C + G C++D+N C PC G +C N ++C C
Sbjct: 165 -CVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTL-GSFQCLC 222
Query: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVP---SGFE-CHCPSGWSGPTCALDIDECAS 391
P G G CE C C+NGG+C +P S F C CP G+ GP C ++ D C S
Sbjct: 223 PVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVS 282
Query: 392 NPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECE--GKP-CLNAFSCKNLIGGYYCD 448
+ C GGTC D +D + C+CPE W G C D +ECE G P C N +C+N G ++C
Sbjct: 283 HQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCV 342
Query: 449 CIPGWKGINCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPC 507
C+ GW G +C N++DC C G TC D V + C+CP G G C LE D C S PC
Sbjct: 343 CVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLE-DMCLSQPC 401
Query: 508 HSGGLC--EDLADGFHCHCPQGFSGPLCEVDVDLC-----EPSPCRNGARCYNLEGDYYC 560
H C L C C G+SGP C D+D C PSPC +G C N G + C
Sbjct: 402 HGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNC 461
Query: 561 ACPDDFGGKNCSVPREPC------PGGAC-RVIDGCGSDAGPGMPG--------TAASGV 605
CP + G C C PG C ++ PG+ G AS
Sbjct: 462 LCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAP 521
Query: 606 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSG 665
C H C G F CIC GF+GT C E+ID+C PC NGG C D+ AF C C G
Sbjct: 522 CLNHADCHDLLNG-FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPG 580
Query: 666 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGK------------------ 707
+EG C T ++CL DPC C DL F+C C G+ G+
Sbjct: 581 FEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQIC 640
Query: 708 -------------------------TCHSREFQCDAYTCSNG------------------ 724
TCH Q + C G
Sbjct: 641 KDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPC 700
Query: 725 ---GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGW 781
GTCY + C CP G+ G TC+ + ++C PC+NGG+C S + C C
Sbjct: 701 AHGGTCYPQPSGYNCTCPTGYTGPTCS-EEMTACHSGPCLNGGSCNPSPGGYYCTCPPSH 759
Query: 782 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINI-DECQSSPCAYGA 840
G C +T+ C PC+NGG CV+ F C CA GF GP C + C SPC A
Sbjct: 760 TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRA 819
Query: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 900
TC D G RC CP G G CQ ++ C + P P S ++ S CL
Sbjct: 820 TCQDSPQGPRCLCPTGYTGGSCQTLMDL---CAQK--PCPRNSHCLQTGPSFHCL----- 869
Query: 901 CSKVWCG------WKPCLLAGQPEAL--SAQCPLGQRCLEKAP----------------- 935
C + W G C A + + S+ C G C++ P
Sbjct: 870 CLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQD 929
Query: 936 --GQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCAR 972
C PC+ C A +P C G+ NC++
Sbjct: 930 HVNPCESRPCQNGATCMA-QPSGYLCQCAPGYDGQNCSK 967
Score = 462 bits (1189), Expect = e-130
Identities = 271/831 (32%), Positives = 364/831 (43%), Gaps = 90/831 (10%)
Query: 231 CMDGWMGKECKEAVCKQGC---NLLHGGCTVPG----ECRCSYGWQGRFC----DECVPY 279
C G++G +C+ V C +GG G C C W G C DEC
Sbjct: 264 CPPGFIGPDCE--VNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQ 321
Query: 280 --PGCVHGSCVE----PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333
P C +G + + C C + WGG C+++L+ C + C G TCI+ + C
Sbjct: 322 GPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAA-TCAPGSTCID-RVGSFSC 379
Query: 334 TCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP--SGFECHCPSGWSGPTCALDIDEC-- 389
CP G +G C E C S PC C P C C G+SGPTC D+DEC
Sbjct: 380 LCPPGRTGLLCH-LEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLM 438
Query: 390 ---ASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYY 446
+PC GG+C++ F C+CP + G+ C+ D NEC +PC +C +L+ ++
Sbjct: 439 AQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFH 498
Query: 447 CDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS 505
C C PG +G C + N+C C + C DL+NG+QC+C GF G CE + DEC SS
Sbjct: 499 CLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSS 558
Query: 506 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
PC +GG C+D FHC C GF GP C+ +VD C PC GA C +L G ++C CP
Sbjct: 559 PCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSG 618
Query: 566 FGGKNCSVPREPCPGGACRVIDGCGS----------DAGPGMPGTAASGVCGPHGRCVSQ 615
F G+ C VP C C+ C D PG + C HG C
Sbjct: 619 FTGQLCEVPL--CAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCH-HGHCQRS 675
Query: 616 PGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 675
SC+CD G+TG C + C+ PC +GGTC + + C CP+G+ G C
Sbjct: 676 -----SCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEM 730
Query: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 735
C PC + G C +YC C G C + C + C NGGTC + TF
Sbjct: 731 TACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFS 790
Query: 736 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 795
C C G++G C SC +PC N TC S C+C G+ G +C + C
Sbjct: 791 CLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQ 850
Query: 796 LPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ----------SSPCAYGATCVDE 845
PC C+ F C C G+ GP C + + CQ SS C G CVD
Sbjct: 851 KPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDS 910
Query: 846 INGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDG--RRDC 901
Y C CPPG G CQ+ + R C + T S ++ C+C G ++C
Sbjct: 911 GPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYL-----CQCAPGYDGQNC 965
Query: 902 SKVW--CGWKPCLLAG----QPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWGECGAE 952
SK C +PC G +P CP +G RC E +CL PC G
Sbjct: 966 SKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRC-EGDVDECLDQPCHPTGTAACH 1024
Query: 953 EPPST---PCLPRSGHLDNNC--------ARLTLHFNRDHVPQGTTVGAIC 992
+ CLP GH C ++ H G+ +G IC
Sbjct: 1025 SLANAFYCQCLP--GHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFIC 1073
Score = 410 bits (1055), Expect = e-114
Identities = 258/795 (32%), Positives = 346/795 (43%), Gaps = 102/795 (12%)
Query: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCT-VPG--ECRCSYGWQGRFC----DECVPYPG 281
C+ G+ G C+E + C+ G C PG C+C G++G C DEC+ P
Sbjct: 539 CLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPC 598
Query: 282 CVHGSCVE---PWQCNCETNWGGLLCDKDL---NYCGSHHPCTNGGTCINAEPDQYRCTC 335
V SC++ + C C + + G LC+ L N C C + + D+ C C
Sbjct: 599 PVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKD-------QKDKANCLC 651
Query: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395
PDG G C E CT + G C C C GW+GP C ++ C S PCA
Sbjct: 652 PDGSPG--CAPPEDNCT----CHHGHCQRS----SCVCDVGWTGPECEAELGGCISAPCA 701
Query: 396 AGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKG 455
GGTC Q G+ C CP + G TC + C PCLN SC GGYYC C P G
Sbjct: 702 HGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTG 761
Query: 456 INCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE-RDECASSPCHSGGLC 513
C + + C C +GGTC + + C+C GF G CE + R CA SPC + C
Sbjct: 762 PQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATC 821
Query: 514 EDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573
+D G C CP G++G C+ +DLC PC + C ++C C + G C++
Sbjct: 822 QDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNL 881
Query: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 633
P C A G S +C G CV G ++ C C GF G+ C
Sbjct: 882 PLSSCQKAALS-------------QGIDVSSLCHNGGLCVDS-GPSYFCHCPPGFQGSLC 927
Query: 634 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693
++++ C +PC+NG TC+ + + C C G++G+ C + C PCH+ G C
Sbjct: 928 QDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKP 987
Query: 694 NDFYCACDDGWKGKTCHSREFQCDAYTCSNGGT--CYDSGDTFRCACPPGWKGSTCAVAK 751
F+CAC G+ G C +C C GT C+ + F C C PG G C V +
Sbjct: 988 GGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEV-E 1046
Query: 752 NSSCLPNPCVNGGTC---VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGV 808
C PC +GGTC GS F C C G+EG TC+H C C++GG+C+
Sbjct: 1047 IDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSP 1106
Query: 809 NWF---RCECAPGFAGPDCRI--NIDEC-QSSPCAYGATCVDEIN----GYRCSCPPGRA 858
RC C G+ GPDC C SPC Y +C + G+RCSCP
Sbjct: 1107 KPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSP 1166
Query: 859 GPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWK--PCLLAGQ 916
GPRCQ+ G G S C++ CS W C L G
Sbjct: 1167 GPRCQK----------PGAKGCEGRSGDGACDA--------GCSGPGGNWDGGDCSL-GV 1207
Query: 917 PEALSAQCPLGQRC-LEKAPGQCLRPPCEAWGEC-----GAEEPPSTPCLPRSGHLDNNC 970
P+ CP RC L GQC P C++ EC E PP+ C P D C
Sbjct: 1208 PDPWKG-CPSHSRCWLLFRDGQC-HPQCDS-EECLFDGYDCETPPA--CTPA---YDQYC 1259
Query: 971 ARLTLHFNRDHVPQG 985
HF+ H +G
Sbjct: 1260 HD---HFHNGHCEKG 1271
Score = 399 bits (1026), Expect = e-111
Identities = 248/825 (30%), Positives = 340/825 (41%), Gaps = 170/825 (20%)
Query: 311 CGSH-HPCTNGGTCINAE-------------------PD--------------------- 329
CGS PC NGGTC++ PD
Sbjct: 28 CGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAP 87
Query: 330 ------------QYRCTCPDGYSGRNCE-KAEHACTSNPCANGGSCHEVPSGF-ECHCPS 375
+ CTC G++G C+ K E C + C+ G CH SG +C C
Sbjct: 88 LGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMP 147
Query: 376 GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANEC--EGKPCL 433
GW+G C L D C++NPC GG C+ +C CP + G C+ D NEC + PC
Sbjct: 148 GWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCP 206
Query: 434 NAFSCKNLIGGYYCDCIPGWKGINCHINVNDC--RGQCQHGGTCKDLVNG----YQCVCP 487
SC N +G + C C G +G C + C RG C +GGTC+ + + C+CP
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRG-CSNGGTCQLMPEKDSTFHLCLCP 265
Query: 488 RGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE---PSP 544
GF G CE+ D C S C +GG C+D D + C CP+ ++G C DVD CE P
Sbjct: 266 PGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPH 325
Query: 545 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC------PGGACRVIDGCGSDAGPGMP 598
CRNG C N G ++C C +GG +C + C PG C ID GS + P
Sbjct: 326 CRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTC--IDRVGSFSCLCPP 383
Query: 599 GTAASGVCGPHGRCVSQP------------GGNFSCICDSGFTGTYCHENIDDCL----- 641
G +C C+SQP G+ C+C G++G CH+++D+CL
Sbjct: 384 GRTGL-LCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQG 442
Query: 642 GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACD 701
PC +GG+C++ +F C CP G+ G C+ + N+CL PCH C DL+ F+C C
Sbjct: 443 PSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCP 502
Query: 702 DGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCV 761
G +G+ C +C + C N C+D + F+C C PG+ G+ C C +PC
Sbjct: 503 PGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCE-EDIDECRSSPCA 561
Query: 762 NGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAG 821
NGG C +F C C G+EG C ++C PC G C+D F C C GF G
Sbjct: 562 NGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTG 621
Query: 822 ------------------------------PD-----------CRINIDECQSSPC---- 836
PD C + CQ S C
Sbjct: 622 QLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDV 681
Query: 837 -------------------AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRS--CWSR 875
A+G TC + +GY C+CP G GP C E + S C +
Sbjct: 682 GWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNG 741
Query: 876 GTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAG----QPEALSAQCPL---GQ 928
G+ P + C + S +C PC G +P S C + G
Sbjct: 742 GSCNPSPGGYYCTCPPSH-TGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGP 800
Query: 929 RCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARL 973
RC K C PC C + P CL +G+ +C L
Sbjct: 801 RCEGKLRPSCADSPCRNRATC-QDSPQGPRCLCPTGYTGGSCQTL 844
Score = 124 bits (312), Expect = 4e-28
Identities = 112/392 (28%), Positives = 148/392 (37%), Gaps = 54/392 (13%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFC----DECVPYPG 281
C G+ G C++ V G T + C+C+ G+ G+ C D C P
Sbjct: 918 CPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPC 977
Query: 282 CVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI-NAEPDQYRCTCPD 337
HG+C + C C + GL C+ D++ C PC GT ++ + + C C
Sbjct: 978 HNHGTCTPKPGGFHCACPPGFVGLRCEGDVDEC-LDQPCHPTGTAACHSLANAFYCQCLP 1036
Query: 338 GYSGRNCEKAEHACTSNPCANGGSCHEV---PSGFECHCPSGWSGPTCALDIDECASNPC 394
G++G+ CE C S PC +GG+C P GF CHCP G+ GPTC+ C + C
Sbjct: 1037 GHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHC 1096
Query: 395 AAGGTCV-DQVDGF--ECICPEQWVGATCQLDANECEG----KPCLNAFSCKNLIG---- 443
GG C+ GF C C + G C L +G PCL SC G
Sbjct: 1097 HHGGLCLPSPKPGFPPRCACLSGYGGPDC-LTPPAPKGCGPPSPCLYNGSCSETTGLGGP 1155
Query: 444 GYYCDCIPGWKGINCH-INVNDCRGQCQHGGTCKDLVNGYQCVCPRG-FGGRHCEL-ERD 500
G+ C C G C C G+ G C P G + G C L D
Sbjct: 1156 GFRCSCPHSSPGPRCQKPGAKGCEGRSGDGAC------DAGCSGPGGNWDGGDCSLGVPD 1209
Query: 501 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 560
P HS C L CH P C+ + L + C C Y
Sbjct: 1210 PWKGCPSHS--RCWLLFRDGQCH-------PQCDSEECLFDGYDCETPPACTPAYDQY-- 1258
Query: 561 ACPDDFGG----KNCSVPREPCPGGACRVIDG 588
C D F K C+ GG CR DG
Sbjct: 1259 -CHDHFHNGHCEKGCNTAECGWDGGDCRPEDG 1289
Score = 40.8 bits (94), Expect = 0.008
Identities = 52/212 (24%), Positives = 74/212 (34%), Gaps = 37/212 (17%)
Query: 230 ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPG----CVHG 285
AC+ G+ G +C +GC C G C + G G PG C H
Sbjct: 1115 ACLSGYGGPDCLTPPAPKGCG-PPSPCLYNGSCSETTGLGG---------PGFRCSCPHS 1164
Query: 286 S----CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSG 341
S C +P CE G CD + G + +GG C PD ++ CP S
Sbjct: 1165 SPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGN---WDGGDCSLGVPDPWK-GCP---SH 1217
Query: 342 RNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCV 401
C +P + C + G++C P P C D+ + G C
Sbjct: 1218 SRCWLLFRDGQCHPQCDSEEC--LFDGYDCETP-----PACTPAYDQYCHDH-FHNGHCE 1269
Query: 402 DQVDGFECICPEQWVGATCQLDANECEGKPCL 433
+ EC W G C+ + + E P L
Sbjct: 1270 KGCNTAEC----GWDGGDCRPEDGDPEWGPSL 1297
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 380 bits (975), Expect = e-105
Identities = 214/653 (32%), Positives = 283/653 (43%), Gaps = 66/653 (10%)
Query: 304 CDKDLNYCGSHHPCTNGGTCIN---AEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGG 360
C + C + PC NGG CI+ Y C+C G++GR C + C S PC NGG
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGG 324
Query: 361 SCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
+C + F C CP+G+ GPTC C + C GG C + C+C + GA C
Sbjct: 325 TCTHGINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAAC 384
Query: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC----HINVNDC-RGQCQHGGTC 475
++D ++C PCLN SC +L+G Y C C +KG+ C H + C C +GGTC
Sbjct: 385 EMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC 444
Query: 476 KDLVNGYQCVCPRGFGGRHC-ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
D GY C CP GF G C E D+C C +GG C A+ C CP GF G LCE
Sbjct: 445 VDADQGYVCECPEGFMGLDCRERVPDDC---ECRNGGRCLG-ANTTLCQCPLGFFGLLCE 500
Query: 535 VDVDLCE---PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVP----REPC-PGGACRVI 586
++ + C +G C G Y C C D + S+P +PC GG+C
Sbjct: 501 FEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASH-SLPSPCDSDPCFNGGSCDAH 559
Query: 587 DGC----------GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCH-E 635
D G P +SG C G C + GG + C C FTG +C
Sbjct: 560 DDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTC-KEAGGEYHCSCPYRFTGRHCEIG 618
Query: 636 NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND 695
D C PC NGGTC + ++C CP G+ G C+ P+ C PC + G C D D
Sbjct: 619 KPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTD 678
Query: 696 FYCACDDGWKGKTCHSREFQCD---------------------AYTCSNGGTCYDSGDTF 734
F+C C G+ G+ C + E C Y C G + +
Sbjct: 679 FFCHCQAGYMGRRCQA-EVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYS-LSAPSRI 736
Query: 735 RCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCN 794
R P G + C PC++GG+C A + C+C G+EG C ++C
Sbjct: 737 RVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECR 796
Query: 795 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCP 854
PC NGG C + + C C GF G C +D C SSPC +G C Y C CP
Sbjct: 797 AHPCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCP 856
Query: 855 PGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDG--RRDCSK 903
G C+ V F C RG S +SC C G DC+K
Sbjct: 857 ESFFGYHCETVSDPCFSSPCGGRGYCLASNGS-----HSCTCKVGYTGEDCAK 904
Score = 333 bits (854), Expect = 6e-91
Identities = 195/643 (30%), Positives = 275/643 (42%), Gaps = 112/643 (17%)
Query: 221 YTCDQYGNKACMDGWMGK-------ECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC 273
YTC +C+ G+ G+ EC C+ G HG + C+C G+ G C
Sbjct: 295 YTC------SCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSF--RCQCPAGFGGPTC 346
Query: 274 D---------ECVPYPGC--VHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGT 322
+ EC C +GS V C C+ + G C+ D++ C S PC NGG+
Sbjct: 347 ETAQSPCDTKECQHGGQCQVENGSAV----CVCQAGYTGAACEMDVDDC-SPDPCLNGGS 401
Query: 323 CINAEPDQYRCTCPDGYSGRNCEKAEH----ACTSNPCANGGSCHEVPSGFECHCPSGWS 378
C++ Y C C + + G CE +H AC S PC NGG+C + G+ C CP G+
Sbjct: 402 CVDL-VGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFM 460
Query: 379 GPTCALDI-DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD-------------- 423
G C + D+C C GG C+ + C CP + G C+ +
Sbjct: 461 GLDCRERVPDDC---ECRNGGRCLG-ANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPD 516
Query: 424 -------------------------ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC 458
+ C+ PC N SC Y C+C G+ G +C
Sbjct: 517 GGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHC 576
Query: 459 H-INVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELER-DECASSPCHSGGLCED 515
+ C G C++GGTCK+ Y C CP F GRHCE+ + D CAS PCH+GG C
Sbjct: 577 EKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFH 636
Query: 516 LADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 575
+ C CP GFSG CE+ C SPC NG C + + D++C C + G+ C
Sbjct: 637 YIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEV 696
Query: 576 EPCP------------GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCI 623
+ P G + D G + + VC PHG P C+
Sbjct: 697 DCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPP----QCL 752
Query: 624 CDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPC 683
ID+C QPC +GG+C D V + C C +G+EG C+ ++C PC
Sbjct: 753 ------------EIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAHPC 800
Query: 684 HSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK 743
+ G C +L + C C G+ G C + CD+ C +GG C G + C CP +
Sbjct: 801 RNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFF 860
Query: 744 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC 786
G C + C +PC G C+ S S SC C+ G+ G C
Sbjct: 861 GYHCETV-SDPCFSSPCGGRGYCLASNGSHSCTCKVGYTGEDC 902
Score = 277 bits (708), Expect = 5e-74
Identities = 158/492 (32%), Positives = 222/492 (45%), Gaps = 111/492 (22%)
Query: 221 YTCDQYGNKACMDGWMGKECKEAV-----CKQGCNLLHGGCTVPGECRCSYGWQGRFCD- 274
Y C+ C +G+MG +C+E V C+ G L T+ C+C G+ G C+
Sbjct: 451 YVCE------CPEGFMGLDCRERVPDDCECRNGGRCLGANTTL---CQCPLGFFGLLCEF 501
Query: 275 ECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHH--------PCTNGGTCINA 326
E P ++ C P C + G LC ++ SH PC NGG+C +A
Sbjct: 502 EITAMPCNMNTQC--PDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSC-DA 558
Query: 327 EPDQYRCTCPDGYSGRNCEKAE-HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALD 385
D Y C CP G+ G++CEKA H C+S PC NGG+C E + C CP ++G C +
Sbjct: 559 HDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIG 618
Query: 386 I-DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKN---- 440
D CAS PC GGTC + ++C CP + G C++ + C PC+N +C++
Sbjct: 619 KPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTD 678
Query: 441 ---------------------------------------LIGGYYCD------------- 448
+ Y CD
Sbjct: 679 FFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRV 738
Query: 449 CIPG--WKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASS 505
C P W + +++CR Q C HGG+C+D V GY C+C G+ G HCELERDEC +
Sbjct: 739 CQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELERDECRAH 798
Query: 506 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
PC +GG C +L + C CP GF G CE +VD C+ SPC++G RC + G Y C CP+
Sbjct: 799 PCRNGGSCRNLPGAYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPES 858
Query: 566 FGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICD 625
F G +C +PC S CG G C++ G+ SC C
Sbjct: 859 FFGYHCETVSDPC-----------------------FSSPCGGRGYCLAS-NGSHSCTCK 894
Query: 626 SGFTGTYCHENI 637
G+TG C + +
Sbjct: 895 VGYTGEDCAKEL 906
Score = 243 bits (619), Expect = 1e-63
Identities = 157/513 (30%), Positives = 214/513 (41%), Gaps = 91/513 (17%)
Query: 503 ASSPCHSGGLC-EDLADG---FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDY 558
A PC +GG C +D G + C C GF+G C +DV+ C PC+NG C + +
Sbjct: 274 ALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSF 333
Query: 559 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618
C CP FGG C + PC C+ HG G
Sbjct: 334 RCQCPAGFGGPTCETAQSPCDTKECQ------------------------HGGQCQVENG 369
Query: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTN---- 674
+ C+C +G+TG C ++DDC PC NGG+C+D V + C C ++G C+T
Sbjct: 370 SAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPV 429
Query: 675 PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTF 734
P+ CL PCH+ G C D + C C +G+ G C RE D C NGG C + T
Sbjct: 430 PDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDC--RERVPDDCECRNGGRCLGANTTL 487
Query: 735 RCACPPGWKGSTCA--VAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT-N 791
C CP G+ G C + + C +GG C+ G S+ C+C +H+ +
Sbjct: 488 -CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTD---HNASHSLPS 543
Query: 792 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC-RINIDECQSSPCAYGATCVDEINGYR 850
C+ PC+NGG C + + CEC GF G C + C S PC G TC + Y
Sbjct: 544 PCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYH 603
Query: 851 CSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKP 910
CSCP G C+ IG SC S P +G + +C DC
Sbjct: 604 CSCPYRFTGRHCE--IGKPDSCASG--PCHNGGTCFHYIGKYKC-----DC--------- 645
Query: 911 CLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
P S G+ C E AP C R PC G C + C ++G++ C
Sbjct: 646 ------PPGFS-----GRHC-EIAPSPCFRSPCVNGGTC-EDRDTDFFCHCQAGYMGRRC 692
Query: 971 ------------ARLTLHFNRDHVPQGTTVGAI 991
TL FN GT +GA+
Sbjct: 693 QAEVDCGPPEEVKHATLRFN------GTRLGAV 719
Score = 173 bits (438), Expect = 1e-42
Identities = 114/370 (30%), Positives = 149/370 (40%), Gaps = 78/370 (21%)
Query: 633 CHENIDDCLG-QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 691
C CL +PC NGG CID+ C +G NP+
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDD-------CVTG--------NPS--------------- 294
Query: 692 LVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAK 751
+ C+C G+ G+ CH +C + C NGGTC ++FRC CP G+ G TC A+
Sbjct: 295 ----YTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQ 350
Query: 752 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 811
S C C +GG C S C+C+ G+ G C + +DC+P PC NGG CVD V +
Sbjct: 351 -SPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNY 409
Query: 812 RCECAPGFAGPDCRINI----DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG 867
C CA F G C D C S+PC G TCVD GY C CP G G C+E +
Sbjct: 410 TCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVP 469
Query: 868 FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCL----LAGQPEALSAQ 923
C + G RCL + G+ L + P ++ Q
Sbjct: 470 DDCECRNGG----------------RCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQ 513
Query: 924 CPLGQRCLEKA-----------------PGQCLRPPCEAWGECGAEEPPSTPCLPRSGHL 966
CP G C+E P C PC G C A + T PR H
Sbjct: 514 CPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFH- 572
Query: 967 DNNCARLTLH 976
+C + H
Sbjct: 573 GKHCEKARPH 582
Score = 48.1 bits (113), Expect = 5e-05
Identities = 22/62 (35%), Positives = 30/62 (48%), Gaps = 11/62 (17%)
Query: 754 SCLPNPCVNGGTCVGSGASFSCICRDGWEG-----------RTCTHNTNDCNPLPCYNGG 802
+C NPC NGGTCV + SC C G++G R CT ++ P + GG
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 803 IC 804
+C
Sbjct: 1370 VC 1371
Score = 47.4 bits (111), Expect = 9e-05
Identities = 25/64 (39%), Positives = 30/64 (46%), Gaps = 12/64 (18%)
Query: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE----KAEHACT-------SNPCANGGS 361
S +PC NGGTC+ D + C C G+ GR CE K CT + P GG
Sbjct: 1312 SENPCQNGGTCVPGA-DAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGGV 1370
Query: 362 CHEV 365
CH V
Sbjct: 1371 CHHV 1374
Score = 45.8 bits (107), Expect = 3e-04
Identities = 24/71 (33%), Positives = 30/71 (42%), Gaps = 9/71 (12%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCD 448
C+ NPC GGTCV D C C + G C+L + +PC FS
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPCTRLFS--------ETK 1361
Query: 449 CIPGWKGINCH 459
P W+G CH
Sbjct: 1362 AFPVWEGGVCH 1372
Score = 45.1 bits (105), Expect = 4e-04
Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 1/45 (2%)
Query: 792 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPC 836
+C+ PC NGG CV G + C+C PGF G C + + S PC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKV-SRPC 1353
Score = 42.4 bits (98), Expect = 0.003
Identities = 15/34 (44%), Positives = 21/34 (61%)
Query: 639 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 672
+C PC+NGGTC+ DA C C G++G C+
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 40.0 bits (92), Expect = 0.014
Identities = 15/34 (44%), Positives = 19/34 (55%)
Query: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEV 535
C+ +PC +GG C AD C C GF G CE+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 39.3 bits (90), Expect = 0.024
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 11/62 (17%)
Query: 463 NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE-----------RDECASSPCHSGG 511
N CQ+GGTC + + C C GF GR CEL E + P GG
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEGG 1369
Query: 512 LC 513
+C
Sbjct: 1370 VC 1371
Score = 39.3 bits (90), Expect = 0.024
Identities = 14/33 (42%), Positives = 18/33 (54%)
Query: 831 CQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863
C +PC G TCV + + C C PG G RC+
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 38.9 bits (89), Expect = 0.031
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC 394
C+ NPC NGG+C C C G+ G C L + S PC
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIK-VSRPC 1353
Score = 34.3 bits (77), Expect = 0.76
Identities = 18/65 (27%), Positives = 28/65 (43%), Gaps = 11/65 (16%)
Query: 675 PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCH----------SREF-QCDAYTCSN 723
P +C +PC + G C + C C G+KG+ C +R F + A+
Sbjct: 1308 PGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWE 1367
Query: 724 GGTCY 728
GG C+
Sbjct: 1368 GGVCH 1372
Score = 34.3 bits (77), Expect = 0.76
Identities = 13/34 (38%), Positives = 17/34 (50%)
Query: 427 CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI 460
C PC N +C + CDC PG+KG C +
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
Score = 31.2 bits (69), Expect = 6.4
Identities = 11/34 (32%), Positives = 16/34 (47%)
Query: 540 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573
C +PC+NG C + C C F G+ C +
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCEL 1344
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 373 bits (958), Expect = e-103
Identities = 206/653 (31%), Positives = 298/653 (45%), Gaps = 85/653 (13%)
Query: 238 KECKEAVCKQGCNLLHGGCTVPGEC--RCSYGWQGRFC----DECVPYPGCVHGS----- 286
++CK A CK G H + G +C G++G C DEC +P C +G+
Sbjct: 645 EDCKSASCKNGTTSTH----LRGYFFRKCVPGFKGTQCEIDIDECASHP-CKNGATCIDQ 699
Query: 287 -------CVEPWQ------CNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333
CV P++ C C + G+ C++D++ C + C + TC + Y+C
Sbjct: 700 PGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDC-ILNACEHNSTCKDLHL-SYQC 757
Query: 334 TCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP 393
C + G CE+ + C NPC N +C ++ + C C SGW+G C+ +I+EC S+P
Sbjct: 758 VCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP 817
Query: 394 CAAGGTCVDQV--DGFECICPEQWVGATCQLDANECE--GKPCLNAFSCKNLI-GGYYCD 448
C GG C + F C+CP + G C N C+ PC N +C L+ +C
Sbjct: 818 CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCI 877
Query: 449 CIPGWKGINCHINVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPC 507
C ++G NC I+V DC CQ G C+D+VN ++C+C GF G CE+E +EC+S PC
Sbjct: 878 CREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPC 937
Query: 508 HSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFG 567
+ G C DL + F C+C + GP CE+DV+ C+ SPC + C Y C C +
Sbjct: 938 KNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYT 997
Query: 568 GKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSG 627
G NC + + C C G G+ +++C C SG
Sbjct: 998 GINCEINLDECLSEPCL------------HDGVCIDGI------------NHYTCDCKSG 1033
Query: 628 FTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 687
F GT+C N +DCL PC + G C + ++ + C C + C NDC PC + G
Sbjct: 1034 FFGTHCETNANDCLSNPCLH-GRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEG 1092
Query: 688 RCYDLVNDFYCACDDGWKGKTCHSREFQC-----DAYTCSNGGTCYDS-GDTFRCACPPG 741
C + F C C G+ G C C ++ C NGG C D G TF C C PG
Sbjct: 1093 FCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPG 1152
Query: 742 WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNG 801
+ G C + N C +PC++G C + C C+ GW G C N +C P C +
Sbjct: 1153 FSGQFCEININ-ECSSSPCLHGADCEDHINGYVCKCQPGWSGHHC-ENELECIPNSCVH- 1209
Query: 802 GICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCP 854
+C++ C C PGF C+ G C DEI C P
Sbjct: 1210 ELCMENEPGSTCLCTPGF--------------MTCSIGLLCGDEIRRITCLTP 1248
Score = 347 bits (890), Expect = 4e-95
Identities = 207/737 (28%), Positives = 299/737 (40%), Gaps = 92/737 (12%)
Query: 276 CVPYPGCVHGSCVEPWQCNCETNWGGLL-----CDKDLNYCGSHHPCTNGGTCINAEPDQ 330
C C+ + ++ C W G + D N C C + E ++
Sbjct: 535 CANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENECQHEAVCKD-------EINR 587
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCAN-GGSCHEVPSGFECHCPSGWSGPTCALDIDEC 389
RC+C Y GR C C N + G C + C + C +D ++C
Sbjct: 588 PRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDC 647
Query: 390 ASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDC 449
S C G T F C + G C++D +EC PC N +C + G Y+C C
Sbjct: 648 KSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQC 707
Query: 450 IP--------------GWKGINCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRH 494
+P G+ GI C +++DC C+H TCKDL YQCVC + G
Sbjct: 708 VPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNF 767
Query: 495 CELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYN- 553
CE E +EC +PC + C DL + C C G++G C +++ C+ PC NG C+
Sbjct: 768 CEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHES 827
Query: 554 -LEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRC 612
+ G + C CP + G+ C C C + C
Sbjct: 828 TIPGQFVCLCPPLYTGQFCHQRYNLCD---------------------LLHNPCRNNSTC 866
Query: 613 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCD 672
++ N CIC F G C ++ DCL C++ G C D V+ FRC C G+ G LC+
Sbjct: 867 LALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCE 926
Query: 673 TNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD 732
N+C +PC + G C DL N F+C C+ + G C +C C + C D
Sbjct: 927 IEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD 986
Query: 733 TFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTND 792
+ C C PG+ G C + CL PC++ G C+ ++C C+ G+ G C N ND
Sbjct: 987 GYNCLCAPGYTGINCEI-NLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNAND 1045
Query: 793 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCS 852
C PC +G C + +N + C C C+I I++C S PC C +G+ C
Sbjct: 1046 CLSNPCLHGR-CTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCI 1104
Query: 853 CPPGRAGPRCQEVI---------------------GFGRSCWSRGTPFPHGSSW---VED 888
CP G G C++ I G G + R P G + +
Sbjct: 1105 CPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININE 1164
Query: 889 CNSCRCLDGRRDCS--------KVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQ-CL 939
C+S CL G DC K GW + E + C + + C+E PG CL
Sbjct: 1165 CSSSPCLHG-ADCEDHINGYVCKCQPGWSGHHCENELECIPNSC-VHELCMENEPGSTCL 1222
Query: 940 RPP----CEAWGECGAE 952
P C CG E
Sbjct: 1223 CTPGFMTCSIGLLCGDE 1239
Score = 317 bits (811), Expect = 6e-86
Identities = 227/834 (27%), Positives = 322/834 (38%), Gaps = 192/834 (23%)
Query: 190 LELQIRVR---CDENYYSATCNKFCRPRNDFFGH-YTCDQYGNKACMDGWMGKECKEA-V 244
L L + V+ C E+ S C+ + ++ + Y+C C + GK C+E
Sbjct: 163 LRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCH------CQPPFSGKYCQELDA 216
Query: 245 CKQGCNLLHGGCTVPGE--------CRCSYGWQGRFCDE----CVPYPGCVHGSCVE--- 289
C +G C E C C + G+ C E C P+ C HG+C
Sbjct: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHV-CFHGNCSNITS 275
Query: 290 -PWQCNCETNWGGLLCDKDLNYC------------------------GSHH--------- 315
+ C C+ + G C+ C GS
Sbjct: 276 NSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSE 335
Query: 316 ----PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFEC 371
PC NG CI D C C ++ C+ + +C S P N +C + + C
Sbjct: 336 FSLVPCQNGTDCIKISND-VMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPC 394
Query: 372 HCPSGWSGPTCALDIDE----------------------------CASNPC--------- 394
C SG++ C ID C NPC
Sbjct: 395 SCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLI 454
Query: 395 ---------AAGGTCVDQ---------------VDGFEC---ICPEQWVGATCQLDA--- 424
G C D+ +G +C I ++ A C DA
Sbjct: 455 HQHLCYCGVTFHGICQDKGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYV 514
Query: 425 -------------NECEGKPCLNAFSCKNLIGG--YYCDCIPGWKGINCHIN--VNDCRG 467
+E + C N SC + Y C W G N ++ +D
Sbjct: 515 NDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAG-NMYLENTTDDQEN 573
Query: 468 QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHS-GGLCEDLADGFHCHCPQ 526
+CQH CKD +N +C C + GR C + D C + S GLC L+ +C Q
Sbjct: 574 ECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQ 633
Query: 527 GFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVI 586
+ +CE+D + C+ + C+NG +L G ++ C F G C + + C
Sbjct: 634 RYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDEC-------- 685
Query: 587 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG-------------NFSCICDSGFTGTYC 633
AS C C+ QPG FSC+C+ G+ G C
Sbjct: 686 ---------------ASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRC 730
Query: 634 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693
++IDDC+ C + TC D +++C C S WEG C+ N+C +PC + C DL
Sbjct: 731 EQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLY 790
Query: 694 NDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS--GDTFRCACPPGWKGSTCAVAK 751
+ C C GW G+ C +CD+ C NGG C++S F C CPP + G C
Sbjct: 791 KSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRY 850
Query: 752 N-SSCLPNPCVNGGTCVG-SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVN 809
N L NPC N TC+ A+ CICR+ +EG+ C + DC L C + G C D VN
Sbjct: 851 NLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVN 910
Query: 810 WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863
FRC C PGF+G C I I+EC S PC TCVD N + C+C P GP C+
Sbjct: 911 NFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCE 964
Score = 313 bits (801), Expect = 8e-85
Identities = 179/565 (31%), Positives = 252/565 (44%), Gaps = 61/565 (10%)
Query: 194 IRVRCDENYYSATCNKFCRPRN---DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQG 248
+ +RC+++ N C + D Y C C+ W G C++ CK
Sbjct: 726 VGIRCEQDIDDCILNA-CEHNSTCKDLHLSYQC------VCLSDWEGNFCEQESNECKMN 778
Query: 249 CNLLHGGCT---VPGECRCSYGWQGRFC----DECVPYPGCVHGSCVE---PWQ--CNCE 296
+ CT C C+ GW G+ C +EC P G C E P Q C C
Sbjct: 779 PCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCP 838
Query: 297 TNWGGLLCDKDLNYCGS-HHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNP 355
+ G C + N C H+PC N TC+ C C + + G+NCE C
Sbjct: 839 PLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLS 898
Query: 356 CANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQW 415
C + G C ++ + F C C G+SG C ++I+EC+S PC GTCVD + F C C ++
Sbjct: 899 CQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEY 958
Query: 416 VGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGT 474
G C+LD N+C+ PCL+ +C GY C C PG+ GINC IN+++C + C H G
Sbjct: 959 HGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGV 1018
Query: 475 CKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
C D +N Y C C GF G HCE ++C S+PC G C +L + + C C + C+
Sbjct: 1019 CIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGR-CTELINEYPCSCDADGTSTQCK 1077
Query: 535 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG 594
+ ++ C PC N C + C CP + G C + ID C A
Sbjct: 1078 IKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCE-----------KSIDNC---AE 1123
Query: 595 PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE 654
P + S +C G CV PG F C C GF+G +C NI++C PC +G C D
Sbjct: 1124 PELN----SVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDH 1179
Query: 655 VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREF 714
++ + C C GW G C+ N +C+P+ C C + C C G+
Sbjct: 1180 INGYVCKCQPGWSGHHCE-NELECIPNSC-VHELCMENEPGSTCLCTPGF---------- 1227
Query: 715 QCDAYTCSNGGTCYDSGDTFRCACP 739
TCS G C D C P
Sbjct: 1228 ----MTCSIGLLCGDEIRRITCLTP 1248
Score = 237 bits (605), Expect = 5e-62
Identities = 176/707 (24%), Positives = 263/707 (37%), Gaps = 114/707 (16%)
Query: 240 CKEAVCKQGCNLLHGGCTVPG-----ECRCSYGWQGRFCDE---CVPYPGCVHGSCV--- 288
C+E++ + C+ HG C C C + G++C E C P +GSC+
Sbjct: 174 CQESLSSEFCSG-HGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSCINKR 232
Query: 289 -----EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN 343
+ ++C C + G C + + C H C +G C N + + C C + +SG
Sbjct: 233 ENWDEQAYECVCHPPFTGKNCSEIIGQC-QPHVCFHGN-CSNITSNSFICECDEQFSGPF 290
Query: 344 CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQ 403
CE + C S G C S + CP G S D+ E + PC G C+
Sbjct: 291 CEVSAKPCVSLLFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKI 350
Query: 404 VDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVN 463
+ CIC + C+ CE P N +CK Y C CI G+ NC ++
Sbjct: 351 SNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCEKDYPCSCISGFTEKNCEKAID 410
Query: 464 DCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE--CASSPCHSG----GLCE 514
C+ C + C +++ ++ VC G C ++ C+ G G+C+
Sbjct: 411 HCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWFLKNVYLIHQHLCYCGVTFHGICQ 470
Query: 515 DLADG-FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSV 573
D F GF+G G +C + Y+ F NC+
Sbjct: 471 DKGPAQFEYVWQLGFAG---------------SEGEKCQGVIDAYF------FLAANCT- 508
Query: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG-NFSCICDSGFTGTY 632
A V D +++ P +C C+S+ + +C + G
Sbjct: 509 ------EDATYVNDPEDNNSSCWFPHEGTKEICANGCSCLSEEDSQEYRYLCFLRWAGNM 562
Query: 633 CHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHS-RGRCYD 691
EN D C++ C DE++ RC C + G LC N + CL + S G C
Sbjct: 563 YLENTTDDQENECQHEAVCKDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLA 622
Query: 692 LVNDFYCA--------------------------------------CDDGWKGKTCHSRE 713
L ++ C+ C G+KG C
Sbjct: 623 LSHNCNCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDI 682
Query: 714 FQCDAYTCSNGGTCYDSG--------------DTFRCACPPGWKGSTCAVAKNSSCLPNP 759
+C ++ C NG TC D D F C C PG+ G C C+ N
Sbjct: 683 DECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCE-QDIDDCILNA 741
Query: 760 CVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF 819
C + TC S+ C+C WEG C +N+C PC N C D +RCEC G+
Sbjct: 742 CEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGW 801
Query: 820 AGPDCRINIDECQSSPCAYGATCVDEI--NGYRCSCPPGRAGPRCQE 864
G +C I+EC S PC G C + + C CPP G C +
Sbjct: 802 TGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQ 848
Score = 73.2 bits (178), Expect = 1e-12
Identities = 33/77 (42%), Positives = 44/77 (57%), Gaps = 3/77 (3%)
Query: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV-GSGASFS 774
C TC NGG C +G TF C C P W G+TC ++ SCL N C++ C+ S+S
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC--NQSVSCLNNLCLHQSLCIPDQSFSYS 2936
Query: 775 CICRDGWEGRTCTHNTN 791
C+C GW GR C + T+
Sbjct: 2937 CLCTLGWVGRYCENKTS 2953
Score = 63.2 bits (152), Expect = 2e-09
Identities = 42/116 (36%), Positives = 48/116 (41%), Gaps = 11/116 (9%)
Query: 686 RGRCYDLV--NDFYCACDDGWKGKT---CHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 740
RG DL N + D+ GK CH C + C N GTC + C CP
Sbjct: 2306 RGCILDLQVNNKEFFIIDEARHGKNIENCHVP--WCAHHLCRNNGTCISDNENLFCECPR 2363
Query: 741 GWKGSTCAVAKNSSCLPNPCVNGGTCV-GSGASFSCICRDGWEGRTCTHNTNDCNP 795
+ G C A SC NPC NG TCV SG C+C G G CT N P
Sbjct: 2364 LYSGKLCQFA---SCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 62.4 bits (150), Expect = 3e-09
Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 709 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC-----LPNPCVNG 763
CH+ C C NGGTC +SG + C C GWKGS C S+C P+ C G
Sbjct: 2609 CHASP--CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETV-STCDPEHDPPHHCSRG 2665
Query: 764 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 795
TC+ ++C C G G C + +P
Sbjct: 2666 ATCISLPHGYTCFCPLGTTGIYCEQALSISDP 2697
Score = 60.5 bits (145), Expect = 1e-08
Identities = 30/82 (36%), Positives = 37/82 (45%), Gaps = 6/82 (7%)
Query: 421 QLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ------CQHGGT 474
Q A+ C C N +C YC+C GWKG C V+ C + C G T
Sbjct: 2608 QCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 475 CKDLVNGYQCVCPRGFGGRHCE 496
C L +GY C CP G G +CE
Sbjct: 2668 CISLPHGYTCFCPLGTTGIYCE 2689
Score = 59.7 bits (143), Expect = 2e-08
Identities = 28/94 (29%), Positives = 45/94 (47%), Gaps = 8/94 (8%)
Query: 336 PDGY--SGRNCEKAEHA-CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDEC--- 389
P+G+ +GR+ + + C+ C NGG+C E + C+C +GW G C + C
Sbjct: 2596 PEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPE 2655
Query: 390 --ASNPCAAGGTCVDQVDGFECICPEQWVGATCQ 421
+ C+ G TC+ G+ C CP G C+
Sbjct: 2656 HDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 59.3 bits (142), Expect = 2e-08
Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 5/83 (6%)
Query: 789 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP-----CAYGATCV 843
+ + C+ + C NGG C++ C C G+ G C + C C+ GATC+
Sbjct: 2610 HASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI 2669
Query: 844 DEINGYRCSCPPGRAGPRCQEVI 866
+GY C CP G G C++ +
Sbjct: 2670 SLPHGYTCFCPLGTTGIYCEQAL 2692
Score = 59.3 bits (142), Expect = 2e-08
Identities = 27/73 (36%), Positives = 35/73 (47%), Gaps = 2/73 (2%)
Query: 350 ACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCV-DQVDGFE 408
AC N C NGG C + F C C W+G TC + C +N C C+ DQ +
Sbjct: 2878 ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYS 2936
Query: 409 CICPEQWVGATCQ 421
C+C WVG C+
Sbjct: 2937 CLCTLGWVGRYCE 2949
Score = 58.9 bits (141), Expect = 3e-08
Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 5/77 (6%)
Query: 753 SSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCN-----PLPCYNGGICVDG 807
S C C NGGTC+ SG S C C GW+G CT + C+ P C G C+
Sbjct: 2612 SPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL 2671
Query: 808 VNWFRCECAPGFAGPDC 824
+ + C C G G C
Sbjct: 2672 PHGYTCFCPLGTTGIYC 2688
Score = 56.2 bits (134), Expect = 2e-07
Identities = 27/82 (32%), Positives = 40/82 (48%), Gaps = 2/82 (2%)
Query: 744 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 803
GS ++C N C NGG C +G +FSC C W G TC + + N L C + +
Sbjct: 2868 GSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNL-CLHQSL 2926
Query: 804 CVDGVNW-FRCECAPGFAGPDC 824
C+ ++ + C C G+ G C
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYC 2948
Score = 55.5 bits (132), Expect = 3e-07
Identities = 28/79 (35%), Positives = 38/79 (48%), Gaps = 8/79 (10%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC-----TSNPCANGGSCHEVPSGFEC 371
C NGGTCI + Y C C G+ G C + C + C+ G +C +P G+ C
Sbjct: 2619 CGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 372 HCPSGWSGPTC--ALDIDE 388
CP G +G C AL I +
Sbjct: 2678 FCPLGTTGIYCEQALSISD 2696
Score = 55.1 bits (131), Expect = 4e-07
Identities = 32/88 (36%), Positives = 45/88 (51%), Gaps = 5/88 (5%)
Query: 798 CYNGGICV-DGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEIN-GYRCSCPP 855
C N G C+ D N F CEC ++G C+ C+++PC GATCV + C CP
Sbjct: 2344 CRNNGTCISDNENLF-CECPRLYSGKLCQFA--SCENNPCGNGATCVPKSGTDIVCLCPY 2400
Query: 856 GRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
GR+GP C + I + +S F + S
Sbjct: 2401 GRSGPLCTDAINITQPRFSGTDAFGYTS 2428
Score = 55.1 bits (131), Expect = 4e-07
Identities = 36/106 (33%), Positives = 49/106 (46%), Gaps = 11/106 (10%)
Query: 609 HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEG 668
H R + P G+ ++G + CH + C C NGGTCI+ + C C +GW+G
Sbjct: 2589 HFRGLGNPEGH----PNAGRSVGQCHAS--PCSLMKCGNGGTCIESGTSVYCNCTTGWKG 2642
Query: 669 ELCDTNPNDCLP--DPCH--SRG-RCYDLVNDFYCACDDGWKGKTC 709
C + C P DP H SRG C L + + C C G G C
Sbjct: 2643 SFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYC 2688
Score = 54.7 bits (130), Expect = 5e-07
Identities = 27/70 (38%), Positives = 36/70 (51%), Gaps = 8/70 (11%)
Query: 285 GSCVEPWQ---CNCETNWGGLLCDKDLNYCGSHHP----CTNGGTCINAEPDQYRCTCPD 337
G+C+E CNC T W G C + ++ C H C+ G TCI+ P Y C CP
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISL-PHGYTCFCPL 2681
Query: 338 GYSGRNCEKA 347
G +G CE+A
Sbjct: 2682 GTTGIYCEQA 2691
Score = 53.9 bits (128), Expect = 9e-07
Identities = 28/87 (32%), Positives = 42/87 (48%), Gaps = 4/87 (4%)
Query: 457 NCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDL 516
NCH+ C++ GTC C CPR + G+ C+ C ++PC +G C
Sbjct: 2333 NCHVPWC-AHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVPK 2389
Query: 517 AD-GFHCHCPQGFSGPLCEVDVDLCEP 542
+ C CP G SGPLC +++ +P
Sbjct: 2390 SGTDIVCLCPYGRSGPLCTDAINITQP 2416
Score = 53.9 bits (128), Expect = 9e-07
Identities = 27/72 (37%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG-DYYC 560
CA C + G C + C CP+ +SG LC+ CE +PC NGA C G D C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCVPKSGTDIVC 2396
Query: 561 ACPDDFGGKNCS 572
CP G C+
Sbjct: 2397 LCPYGRSGPLCT 2408
Score = 53.5 bits (127), Expect = 1e-06
Identities = 29/89 (32%), Positives = 35/89 (39%), Gaps = 7/89 (7%)
Query: 671 CDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD-----AYTCSNGG 725
C +P C C + G C + YC C GWKG C CD + CS G
Sbjct: 2609 CHASP--CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGA 2666
Query: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSS 754
TC + C CP G G C A + S
Sbjct: 2667 TCISLPHGYTCFCPLGTTGIYCEQALSIS 2695
Score = 52.4 bits (124), Expect = 3e-06
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 606 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP-----CRNGGTCIDEVDAFRC 660
CG G C+ + G + C C +G+ G++C E + C + C G TCI + C
Sbjct: 2619 CGNGGTCI-ESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 661 FCPSGWEGELCD 672
FCP G G C+
Sbjct: 2678 FCPLGTTGIYCE 2689
Score = 52.0 bits (123), Expect = 4e-06
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 5/75 (6%)
Query: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPS-----PCRNGARCYNLEG 556
C+ C +GG C + +C+C G+ G C V C+P C GA C +L
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 557 DYYCACPDDFGGKNC 571
Y C CP G C
Sbjct: 2674 GYTCFCPLGTTGIYC 2688
Score = 51.2 bits (121), Expect = 6e-06
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 7/83 (8%)
Query: 636 NIDDCLG-----QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCY 690
N+ DC G CRNGG C F C C W G C+ + + CL + C + C
Sbjct: 2870 NVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCI 2928
Query: 691 -DLVNDFYCACDDGWKGKTCHSR 712
D + C C GW G+ C ++
Sbjct: 2929 PDQSFSYSCLCTLGWVGRYCENK 2951
Score = 50.8 bits (120), Expect = 8e-06
Identities = 27/88 (30%), Positives = 39/88 (44%), Gaps = 9/88 (10%)
Query: 782 EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGAT 841
+G C +NT C NGG C F C C P +AG C ++ C ++ C + +
Sbjct: 2875 DGTACGYNT-------CRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSL 2926
Query: 842 CV-DEINGYRCSCPPGRAGPRCQEVIGF 868
C+ D+ Y C C G G C+ F
Sbjct: 2927 CIPDQSFSYSCLCTLGWVGRYCENKTSF 2954
Score = 50.1 bits (118), Expect = 1e-05
Identities = 25/81 (30%), Positives = 34/81 (41%), Gaps = 5/81 (6%)
Query: 468 QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP-----CHSGGLCEDLADGFHC 522
+C +GGTC + C C G+ G C C C G C L G+ C
Sbjct: 2618 KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTC 2677
Query: 523 HCPQGFSGPLCEVDVDLCEPS 543
CP G +G CE + + +PS
Sbjct: 2678 FCPLGTTGIYCEQALSISDPS 2698
Score = 50.1 bits (118), Expect = 1e-05
Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 1/75 (1%)
Query: 423 DANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTC-KDLVNG 481
D C C N C + C C+P W G C+ +V+ C H C D
Sbjct: 2875 DGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFS 2934
Query: 482 YQCVCPRGFGGRHCE 496
Y C+C G+ GR+CE
Sbjct: 2935 YSCLCTLGWVGRYCE 2949
Score = 49.7 bits (117), Expect = 2e-05
Identities = 27/82 (32%), Positives = 34/82 (41%), Gaps = 4/82 (4%)
Query: 341 GRNCEKAEHA-CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGT 399
G+N E C + C N G+C C CP +SG C C +NPC G T
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLC--QFASCENNPCGNGAT 2385
Query: 400 CVDQV-DGFECICPEQWVGATC 420
CV + C+CP G C
Sbjct: 2386 CVPKSGTDIVCLCPYGRSGPLC 2407
Score = 48.9 bits (115), Expect = 3e-05
Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 10/89 (11%)
Query: 380 PTCALDIDECASNPCAA-----GGTCVDQVDGFECICPEQWVGATCQLDANECEGK---- 430
P + +C ++PC+ GGTC++ C C W G+ C + C+ +
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPP 2659
Query: 431 -PCLNAFSCKNLIGGYYCDCIPGWKGINC 458
C +C +L GY C C G GI C
Sbjct: 2660 HHCSRGATCISLPHGYTCFCPLGTTGIYC 2688
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/78 (33%), Positives = 33/78 (42%), Gaps = 5/78 (6%)
Query: 633 CHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDL 692
CH + C CRN GTCI + + C CP + G+LC C +PC + C
Sbjct: 2334 CH--VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF--ASCENNPCGNGATCVPK 2389
Query: 693 V-NDFYCACDDGWKGKTC 709
D C C G G C
Sbjct: 2390 SGTDIVCLCPYGRSGPLC 2407
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 590 GSDAGPGMPGTAAS-GVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNG 648
GS+ G GTA C G C G FSC C + G C++++ CL C +
Sbjct: 2868 GSNVGD-CDGTACGYNTCRNGGECTVN-GTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQ 2924
Query: 649 GTCI-DEVDAFRCFCPSGWEGELCD 672
CI D+ ++ C C GW G C+
Sbjct: 2925 SLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 44.7 bits (104), Expect = 6e-04
Identities = 25/76 (32%), Positives = 32/76 (42%), Gaps = 3/76 (3%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIG-GYYC 447
CA + C GTC+ + C CP + G CQ + CE PC N +C G C
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS--CENNPCGNGATCVPKSGTDIVC 2396
Query: 448 DCIPGWKGINCHINVN 463
C G G C +N
Sbjct: 2397 LCPYGRSGPLCTDAIN 2412
Score = 43.9 bits (102), Expect = 0.001
Identities = 31/92 (33%), Positives = 42/92 (45%), Gaps = 8/92 (8%)
Query: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV--DGVNWFR 812
C + C N GTC+ + C C + G+ C + C PC NG CV G +
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFAS--CENNPCGNGATCVPKSGTD-IV 2395
Query: 813 CECAPGFAGPDC--RINIDECQ-SSPCAYGAT 841
C C G +GP C INI + + S A+G T
Sbjct: 2396 CLCPYGRSGPLCTDAINITQPRFSGTDAFGYT 2427
Score = 41.6 bits (96), Expect = 0.005
Identities = 26/77 (33%), Positives = 32/77 (41%), Gaps = 12/77 (15%)
Query: 280 PGCVH------GSCV---EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ 330
P C H G+C+ E C C + G LC C ++PC NG TC+
Sbjct: 2337 PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASC-ENNPCGNGATCVPKSGTD 2393
Query: 331 YRCTCPDGYSGRNCEKA 347
C CP G SG C A
Sbjct: 2394 IVCLCPYGRSGPLCTDA 2410
Score = 40.0 bits (92), Expect = 0.014
Identities = 27/104 (25%), Positives = 35/104 (33%), Gaps = 24/104 (23%)
Query: 537 VDLCEPSPCR-----NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGS 591
V C SPC NG C YC C + G C+ + C
Sbjct: 2606 VGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCT-----------ETVSTCDP 2654
Query: 592 DAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 635
+ P C C+S P G ++C C G TG YC +
Sbjct: 2655 EHDP-------PHHCSRGATCISLPHG-YTCFCPLGTTGIYCEQ 2690
Score = 40.0 bits (92), Expect = 0.014
Identities = 25/84 (29%), Positives = 33/84 (39%), Gaps = 15/84 (17%)
Query: 237 GKECKEAVCKQGCNLLHGGCTVPG---ECRCSYGWQGRFCDECVPYPG--CVHGSCVEP- 290
G C C+ G G CTV G CRC W G C++ V C+H S P
Sbjct: 2876 GTACGYNTCRNG-----GECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPD 2930
Query: 291 ----WQCNCETNWGGLLCDKDLNY 310
+ C C W G C+ ++
Sbjct: 2931 QSFSYSCLCTLGWVGRYCENKTSF 2954
Score = 39.3 bits (90), Expect = 0.024
Identities = 20/47 (42%), Positives = 23/47 (48%), Gaps = 5/47 (10%)
Query: 502 CASSPCHSGGLCED--LADG---FHCHCPQGFSGPLCEVDVDLCEPS 543
C CH+GG C L+ G F C CP F+G CE D L PS
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPS 2149
Score = 39.3 bits (90), Expect = 0.024
Identities = 23/102 (22%), Positives = 35/102 (34%), Gaps = 25/102 (24%)
Query: 537 VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPG 596
V C CRN C + + +C CP + GK C
Sbjct: 2336 VPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF----------------------- 2372
Query: 597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 638
+ + CG CV + G + C+C G +G C + I+
Sbjct: 2373 --ASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN 2412
Score = 38.9 bits (89), Expect = 0.031
Identities = 21/100 (21%), Positives = 34/100 (34%), Gaps = 24/100 (24%)
Query: 534 EVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDA 593
+ D C + CRNG C + C C D+ G C+
Sbjct: 2873 DCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCN--------------------- 2911
Query: 594 GPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 633
+ + +C C+ ++SC+C G+ G YC
Sbjct: 2912 ---QSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYC 2948
Score = 37.7 bits (86), Expect = 0.068
Identities = 18/68 (26%), Positives = 30/68 (44%), Gaps = 2/68 (2%)
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
+ C C +W G C++ ++ ++ C + CI + Y C C G+ GR CE
Sbjct: 2897 FSCRCLPDWAGNTCNQSVSCL--NNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSF 2954
Query: 351 CTSNPCAN 358
T+ N
Sbjct: 2955 STAKFMGN 2962
Score = 37.7 bits (86), Expect = 0.068
Identities = 15/49 (30%), Positives = 23/49 (46%), Gaps = 5/49 (10%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGE-----CRCSYGWQGRFCD 274
C+ W G C ++V LH +P + C C+ GW GR+C+
Sbjct: 2901 CLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 36.2 bits (82), Expect = 0.20
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 6/54 (11%)
Query: 317 CTNGGTC----INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVP 366
C NGGTC +++ ++C CP ++GR CEK A P NG S E+P
Sbjct: 2108 CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK--DAGLFFPSFNGNSYLELP 2159
Score = 35.4 bits (80), Expect = 0.34
Identities = 17/44 (38%), Positives = 23/44 (52%), Gaps = 5/44 (11%)
Query: 347 AEHACTSNPCANGGSCHEV--PSG---FECHCPSGWSGPTCALD 385
A C + C NGG+CH + SG F+C CP ++G C D
Sbjct: 2099 APSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142
Score = 34.3 bits (77), Expect = 0.76
Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 7/65 (10%)
Query: 742 WKGSTCAVAKNSSCLPNPCVNGGTC----VGSG-ASFSCICRDGWEGRTCTHNTNDCNPL 796
W + +VA S C + C NGGTC + SG SF C C + GR C +
Sbjct: 2090 WTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLF--F 2147
Query: 797 PCYNG 801
P +NG
Sbjct: 2148 PSFNG 2152
Score = 33.5 bits (75), Expect = 1.3
Identities = 19/71 (26%), Positives = 29/71 (40%), Gaps = 2/71 (2%)
Query: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY-NLEGDYYC 560
C + C +GG C F C C ++G C V C + C + + C + Y C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-CLNNLCLHQSLCIPDQSFSYSC 2937
Query: 561 ACPDDFGGKNC 571
C + G+ C
Sbjct: 2938 LCTLGWVGRYC 2948
Score = 32.7 bits (73), Expect = 2.2
Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 5/33 (15%)
Query: 469 CQHGGTCKDL-----VNGYQCVCPRGFGGRHCE 496
C +GGTC + + +QC CP F GR CE
Sbjct: 2108 CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
Score = 30.8 bits (68), Expect = 8.4
Identities = 14/41 (34%), Positives = 19/41 (46%), Gaps = 5/41 (12%)
Query: 389 CASNPCAAGGTC-----VDQVDGFECICPEQWVGATCQLDA 424
C + C GGTC + F+C CP + G C+ DA
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDA 2143
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 306 bits (784), Expect = 8e-83
Identities = 161/498 (32%), Positives = 225/498 (45%), Gaps = 73/498 (14%)
Query: 208 NKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPGECRCSY 266
N FC N +C N C D +C C N L C + C
Sbjct: 24 NSFCNKNNTRCLSNSCQN--NSTCKDFSKDNDCS---CSDTANNLDKDCDNMKDPC---- 74
Query: 267 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 326
F + C CV+ + C C + G +C+ + CG + C +GG C +
Sbjct: 75 -----FSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNS-CQHGGIC-HQ 127
Query: 327 EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
+P C CP GY+GR CE C S+PC NG C + G+ C C G+ G C L++
Sbjct: 128 DPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV 187
Query: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYY 446
DECAS+PC TC++++ + CICP + G C+L+ +EC +PCLN +C++ +G Y+
Sbjct: 188 DECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYF 247
Query: 447 CDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCP-RGFGGRHCELERDECAS 504
CDC PG+ G +C +N ++C Q C HGG C D N Y C C GF G HCE C S
Sbjct: 248 CDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWS 307
Query: 505 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD------- 557
PCH+ CED D + CHC G++G CE+D++ C +PC++ C L +
Sbjct: 308 KPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRIT 367
Query: 558 -------------YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 604
Y C C F G +C C +S
Sbjct: 368 GLPSSFSYHEASGYVCICQPGFTGIHCEEDVNEC-----------------------SSN 404
Query: 605 VCGPHGRCVSQPGGNFSCICD------SGFTGTYCHENIDDCLGQPCRNGGTCI----DE 654
C G C + PG N++C C + + G C + + C Q C N GTCI D
Sbjct: 405 PCQNGGTCENLPG-NYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDG 463
Query: 655 VDAFRCFCPSGWEGELCD 672
F C CPSG+ G LC+
Sbjct: 464 QHGFSCLCPSGYTGSLCE 481
Score = 292 bits (748), Expect = 1e-78
Identities = 153/481 (31%), Positives = 210/481 (43%), Gaps = 61/481 (12%)
Query: 382 CALDIDECASNPCAAGGTCVDQVDGFECICPEQW--VGATCQLDANECEGKPCLNAFSCK 439
C + C SN C TC D +C C + + C + C PC + +C
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 440 NLIG--GYYCDCIPGWKGINCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
N G + C C PG+ G C + C + CQHGG C C+CP G+ GR CE
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 497 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG 556
++ DECASSPC +G +C+D DG+ C C G+ G C+++VD C PC+N A C N G
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIG 206
Query: 557 DYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQP 616
Y C CP ++ G NC + + C C +G
Sbjct: 207 RYTCICPHNYSGVNCELEIDECWSQPCL------------------------NGATCQDA 242
Query: 617 GGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCP-SGWEGELCDTNP 675
G + C C GF G +C N D+C QPC +GG C+D + + C C SG+ G C+T
Sbjct: 243 LGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLM 302
Query: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC-------- 727
C PCH+ C D V+++ C C G+ G C +C++ C + G C
Sbjct: 303 PLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQ 362
Query: 728 ------------YDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
Y + C C PG+ G C N C NPC NGGTC +++C
Sbjct: 363 YGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNE-CSSNPCQNGGTCENLPGNYTC 421
Query: 776 IC------RDGWEGRTCTHNTNDCNPLPCYNGGICV----DGVNWFRCECAPGFAGPDCR 825
C R + GR C+ C C N G C+ DG + F C C G+ G C
Sbjct: 422 HCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481
Query: 826 I 826
I
Sbjct: 482 I 482
Score = 259 bits (662), Expect = 1e-68
Identities = 147/480 (30%), Positives = 206/480 (42%), Gaps = 61/480 (12%)
Query: 420 CQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGIN--CHINVNDC-RGQCQHGGTCK 476
C + C C N +CK+ C C ++ C + C CQ TC
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 477 DLVN--GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
+ + C CP G+ G CE C + C GG+C C CP G++G CE
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCE 146
Query: 535 VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAG 594
+D D C SPC+NGA C + Y C C + G++C + +D C SD
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLE-----------VDECASDP- 194
Query: 595 PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE 654
C C+++ G ++CIC ++G C ID+C QPC NG TC D
Sbjct: 195 -----------CKNEATCLNEIG-RYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDA 242
Query: 655 VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACD-DGWKGKTCHSRE 713
+ A+ C C G+ G+ C+ N ++C PC G C D N + C C G+ G C +
Sbjct: 243 LGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLM 302
Query: 714 FQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCV------ 767
C + C N TC DS D + C C PG+ G+ C + N C NPC + G CV
Sbjct: 303 PLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNE-CNSNPCQSNGECVELSSEK 361
Query: 768 ------GSGASFS--------CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813
G +SFS CIC+ G+ G C + N+C+ PC NGG C + + C
Sbjct: 362 QYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTC 421
Query: 814 ECA------PGFAGPDCRINIDECQSSPCAYGATCV----DEINGYRCSCPPGRAGPRCQ 863
C + G DC + C C TC+ D +G+ C CP G G C+
Sbjct: 422 HCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481
Score = 240 bits (612), Expect = 7e-63
Identities = 134/473 (28%), Positives = 191/473 (40%), Gaps = 65/473 (13%)
Query: 495 CELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG--PLCEVDVDLCEPSPCRNGARCY 552
C C S+ C + C+D + C C + C+ D C +PC+ A C
Sbjct: 27 CNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCV 86
Query: 553 NLEGD--YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHG 610
N G+ + C CP + G C C +C+ HG
Sbjct: 87 NTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQ------------------------HG 122
Query: 611 RCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGEL 670
Q CIC +G+ G +C + D+C PC+NG C D +D + CFC G++G
Sbjct: 123 GICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRH 182
Query: 671 CDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDS 730
CD ++C DPC + C + + + C C + G C +C + C NG TC D+
Sbjct: 183 CDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDA 242
Query: 731 GDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICR-DGWEGRTCTHN 789
+ C C PG+ G C + C PC++GG CV +SC C G+ G C
Sbjct: 243 LGAYFCDCAPGFLGDHCEL-NTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETL 301
Query: 790 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVD----- 844
C PC+N C D V+ + C C PG+ G C I+++EC S+PC CV+
Sbjct: 302 MPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEK 361
Query: 845 ---------------EINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVE 887
E +GY C C PG G C+E + C + GT ++
Sbjct: 362 QYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTC 421
Query: 888 DC---NSCRCLDGRRDCSKV--WCGWKPCLLAGQ--------PEALSAQCPLG 927
C N R G RDCS + C + CL G S CP G
Sbjct: 422 HCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSG 474
Score = 222 bits (566), Expect = 1e-57
Identities = 126/391 (32%), Positives = 170/391 (43%), Gaps = 84/391 (21%)
Query: 231 CMDGWMGKECKEAVCKQGCNLL-HGGCT----VPGECRCSYGWQGRFC----DECVPYP- 280
C G+ G C+ + G N HGG + C C G+ GRFC DEC P
Sbjct: 98 CPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPC 157
Query: 281 --GCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
G V ++ + C C + G CD +++ C S PC N TC+N E +Y C CP
Sbjct: 158 QNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASD-PCKNEATCLN-EIGRYTCICPHN 215
Query: 339 YSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGG 398
YSG NCE C S PC NG +C + + C C G+ G C L+ DECAS PC GG
Sbjct: 216 YSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGG 275
Query: 399 TCVDQVDGFECICPEQ-WVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGIN 457
CVD + + C C + G C+ C KPC N +C++ + Y C C PG+ G
Sbjct: 276 LCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQ 335
Query: 458 CHINVNDCRGQ-CQHGGTCKDL--------------------VNGYQCVCPRGFGGRHCE 496
C I++N+C CQ G C +L +GY C+C GF G HCE
Sbjct: 336 CEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCE 395
Query: 497 LERDECASSPCHSGGLCEDLADGFHCHCP------------------------------- 525
+ +EC+S+PC +GG CE+L + CHCP
Sbjct: 396 EDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGT 455
Query: 526 -----------------QGFSGPLCEVDVDL 539
G++G LCE+ L
Sbjct: 456 CIPHFQDGQHGFSCLCPSGYTGSLCEIATTL 486
Score = 181 bits (458), Expect = 5e-45
Identities = 118/425 (27%), Positives = 171/425 (40%), Gaps = 68/425 (16%)
Query: 631 TYCHENIDDCLGQPCRNGGTCID--------------EVD-------------------- 656
++C++N CL C+N TC D +D
Sbjct: 25 SFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSAT 84
Query: 657 --------AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKT 708
+F C CP G+ G +C+T C + C G C+ C C G+ G+
Sbjct: 85 CVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRF 144
Query: 709 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVG 768
C +C + C NG C D D + C C PG++G C + + C +PC N TC+
Sbjct: 145 CEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDL-EVDECASDPCKNEATCLN 203
Query: 769 SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINI 828
++CIC + G C ++C PC NG C D + + C+CAPGF G C +N
Sbjct: 204 EIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNT 263
Query: 829 DECQSSPCAYGATCVDEINGYRCSCP-PGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVE 887
DEC S PC +G CVD N Y C+C G G C+ ++ CWS+ H ++ E
Sbjct: 264 DECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPL---CWSKPC---HNNATCE 317
Query: 888 DC---NSCRCLDG----RRDCSKVWCGWKPCLLAGQPEALSAQCPLGQ-------RCLEK 933
D +C C G + + C PC G+ LS++ G+ +
Sbjct: 318 DSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHE 377
Query: 934 APGQ-CLRPPCEAWGEC--GAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQGTTVGA 990
A G C+ P C E S PC G +N T H D++ + G
Sbjct: 378 ASGYVCICQPGFTGIHCEEDVNECSSNPC-QNGGTCENLPGNYTCHCPFDNLSRTFYGGR 436
Query: 991 ICSGI 995
CS I
Sbjct: 437 DCSDI 441
Score = 178 bits (451), Expect = 3e-44
Identities = 79/197 (40%), Positives = 108/197 (54%), Gaps = 9/197 (4%)
Query: 349 HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408
+ C SNPC +GG+C ++ S + C CP GWSG C L+IDEC SNPC G C D+V +
Sbjct: 1141 NVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPC-IHGNCSDRVAAYH 1199
Query: 409 CICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC---HINVNDC 465
C C + G C++D + C+ C N +C + GY C C + G C + C
Sbjct: 1200 CTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVC 1259
Query: 466 RGQ-----CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGF 520
+ C +GG C + +C+C GF G CE + DECAS PC +GGLC+DL + F
Sbjct: 1260 GNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKF 1319
Query: 521 HCHCPQGFSGPLCEVDV 537
C C F+G CEVD+
Sbjct: 1320 QCLCDVAFAGERCEVDL 1336
Score = 169 bits (428), Expect = 2e-41
Identities = 73/201 (36%), Positives = 106/201 (52%), Gaps = 9/201 (4%)
Query: 381 TCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKN 440
T L ++ C SNPC GG C D + C CP W G C+L+ +EC PC++ +C +
Sbjct: 1135 TGCLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHG-NCSD 1193
Query: 441 LIGGYYCDCIPGWKGINCHINVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELER 499
+ Y+C C PG+ G+NC +++++C+ QC +G TC NGY C+C F G+ C R
Sbjct: 1194 RVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSR 1253
Query: 500 -------DECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY 552
+E + C++GG C + C C GF+G CE D+D C PC NG C
Sbjct: 1254 LPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQ 1313
Query: 553 NLEGDYYCACPDDFGGKNCSV 573
+L + C C F G+ C V
Sbjct: 1314 DLLNKFQCLCDVAFAGERCEV 1334
Score = 168 bits (426), Expect = 3e-41
Identities = 82/221 (37%), Positives = 113/221 (51%), Gaps = 19/221 (8%)
Query: 460 INVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD 518
+ +N C C HGG C+D+ + Y C CP G+ G+HCEL DEC S+PC G C D
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVA 1196
Query: 519 GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPC 578
+HC C G++G CEVD+D C+ C NGA C + Y C C +F GK C R P
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256
Query: 579 PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENID 638
CG++ + C G C ++ C+C GFTG +C ++ID
Sbjct: 1257 TV--------CGNEK--------TNLTCYNGGNC-TEFQTELKCMCRPGFTGEWCEKDID 1299
Query: 639 DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 679
+C PC NGG C D ++ F+C C + GE C+ + D L
Sbjct: 1300 ECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADDL 1340
Score = 159 bits (402), Expect = 2e-38
Identities = 84/259 (32%), Positives = 122/259 (47%), Gaps = 16/259 (6%)
Query: 667 EGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG--KTCHSREFQCDAYTCSNG 724
+ C+ N CL + C + C D D C+C D K C + + C + C
Sbjct: 23 KNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGS 82
Query: 725 GTCYDSGD--TFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 782
TC ++ +F C CPPG+ G+ C SC N C +GG C CIC G+
Sbjct: 83 ATCVNTPGERSFLCKCPPGYSGTICETT-IGSCGKNSCQHGGICHQDPIYPVCICPAGYA 141
Query: 783 GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 842
GR C + ++C PC NG +C DG++ + C C PG+ G C + +DEC S PC ATC
Sbjct: 142 GRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATC 201
Query: 843 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLDG--- 897
++EI Y C CP +G C+ I CWS+ P +G++ + + C C G
Sbjct: 202 LNEIGRYTCICPHNYSGVNCELEID---ECWSQ--PCLNGATCQDALGAYFCDCAPGFLG 256
Query: 898 -RRDCSKVWCGWKPCLLAG 915
+ + C +PCL G
Sbjct: 257 DHCELNTDECASQPCLHGG 275
Score = 150 bits (380), Expect = 6e-36
Identities = 65/195 (33%), Positives = 97/195 (49%), Gaps = 7/195 (3%)
Query: 640 CLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCA 699
C PC +GG C D ++ C CP GW G+ C+ N ++C +PC G C D V ++C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPC-IHGNCSDRVAAYHCT 1201
Query: 700 CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPN- 758
C+ G+ G C C ++ C+NG TC + + C C + G C ++ S +
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGN 1261
Query: 759 -----PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRC 813
C NGG C C+CR G+ G C + ++C PC NGG+C D +N F+C
Sbjct: 1262 EKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQC 1321
Query: 814 ECAPGFAGPDCRINI 828
C FAG C +++
Sbjct: 1322 LCDVAFAGERCEVDL 1336
Score = 150 bits (379), Expect = 7e-36
Identities = 69/195 (35%), Positives = 97/195 (49%), Gaps = 9/195 (4%)
Query: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 735
N C +PC G C D+ + ++C+C GW GK C +C + C +G C D +
Sbjct: 1141 NVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAYH 1199
Query: 736 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT----- 790
C C PG+ G C V ++ C + C NG TC+ +SC+C + G+ C +
Sbjct: 1200 CTCEPGYTGVNCEVDIDN-CQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258
Query: 791 --NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEING 848
N+ L CYNGG C + +C C PGF G C +IDEC S PC G C D +N
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNK 1318
Query: 849 YRCSCPPGRAGPRCQ 863
++C C AG RC+
Sbjct: 1319 FQCLCDVAFAGERCE 1333
Score = 140 bits (352), Expect = 1e-32
Identities = 66/176 (37%), Positives = 97/176 (55%), Gaps = 17/176 (9%)
Query: 262 CRCSYGWQGRFC----DECVPYPGCVHGSC---VEPWQCNCETNWGGLLCDKDLNYCGSH 314
C C GW G+ C DEC P C+HG+C V + C CE + G+ C+ D++ C SH
Sbjct: 1163 CSCPLGWSGKHCELNIDECFSNP-CIHGNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSH 1221
Query: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAE-------HACTSNPCANGGSCHEVPS 367
C NG TCI+ + Y C C ++G+ C ++ + T+ C NGG+C E +
Sbjct: 1222 Q-CANGATCIS-HTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQT 1279
Query: 368 GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD 423
+C C G++G C DIDECAS+PC GG C D ++ F+C+C + G C++D
Sbjct: 1280 ELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVD 1335
Score = 122 bits (305), Expect = 3e-27
Identities = 69/228 (30%), Positives = 99/228 (43%), Gaps = 33/228 (14%)
Query: 422 LDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC-RGQCQHGGTCKDLVN 480
L N C PCL+ +C+++ Y+C C GW G +C +N+++C C H G C D V
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIH-GNCSDRVA 1196
Query: 481 GYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC---EVDV 537
Y C C G+ G +CE++ D C S C +G C +G+ C C F+G C +
Sbjct: 1197 AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPS 1256
Query: 538 DLCEPS----PCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDA 593
+C C NG C + + C C F G+ C + ID C SD
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCE-----------KDIDECASD- 1304
Query: 594 GPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL 641
P + G G+C F C+CD F G C ++ D L
Sbjct: 1305 -PCVNG----GLC-------QDLLNKFQCLCDVAFAGERCEVDLADDL 1340
Score = 117 bits (292), Expect = 9e-26
Identities = 66/238 (27%), Positives = 106/238 (44%), Gaps = 21/238 (8%)
Query: 234 GWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQC 293
G++ K +E K N + GC C + G C++ ++ S + C
Sbjct: 1115 GFINKPQEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNCED-------IYSS----YHC 1163
Query: 294 NCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTS 353
+C W G C+ +++ C S+ PC +G Y CTC GY+G NCE C S
Sbjct: 1164 SCPLGWSGKHCELNIDECFSN-PCIHGNCSDRVAA--YHCTCEPGYTGVNCEVDIDNCQS 1220
Query: 354 NPCANGGSCHEVPSGFECHCPSGWSGPTCA---LDIDECASNP----CAAGGTCVDQVDG 406
+ CANG +C +G+ C C ++G C L C + C GG C +
Sbjct: 1221 HQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTE 1280
Query: 407 FECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVND 464
+C+C + G C+ D +EC PC+N C++L+ + C C + G C +++ D
Sbjct: 1281 LKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLAD 1338
Score = 109 bits (272), Expect = 2e-23
Identities = 46/110 (41%), Positives = 62/110 (56%), Gaps = 1/110 (0%)
Query: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 814
C NPC++GG C +S+ C C GW G+ C N ++C PC +G C D V + C
Sbjct: 1143 CNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAYHCT 1201
Query: 815 CAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQE 864
C PG+ G +C ++ID CQS CA GATC+ NGY C C G C++
Sbjct: 1202 CEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQ 1251
Score = 65.1 bits (157), Expect = 4e-10
Identities = 29/75 (38%), Positives = 40/75 (53%), Gaps = 1/75 (1%)
Query: 348 EHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGF 407
+++C SNPC NGG CH F C CP+ SG C ++ C +PC G C + GF
Sbjct: 888 DNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGF 946
Query: 408 ECICPEQWVGATCQL 422
ECI + G + Q+
Sbjct: 947 ECIANAVFNGQSGQI 961
Score = 61.2 bits (147), Expect = 6e-09
Identities = 28/71 (39%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 500 DECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY 559
+ C S+PCH+GG+C D F C CP SG CE +V C SPC +GA+C + +
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 560 CACPDDFGGKN 570
C F G++
Sbjct: 948 CIANAVFNGQS 958
Score = 56.2 bits (134), Expect = 2e-07
Identities = 28/71 (39%), Positives = 41/71 (57%), Gaps = 3/71 (4%)
Query: 309 NYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSG 368
N C S+ PC NGG C ++ D + C+CP SG+ CE+ + C +PC +G C V G
Sbjct: 889 NSCKSN-PCHNGGVC-HSRWDDFSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQG 945
Query: 369 FECHCPSGWSG 379
FEC + ++G
Sbjct: 946 FECIANAVFNG 956
Score = 52.0 bits (123), Expect = 4e-06
Identities = 22/61 (36%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 791 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 850
N C PC+NGG+C + F C C +G C + C SPC +GA C + G+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 851 C 851
C
Sbjct: 948 C 948
Score = 50.4 bits (119), Expect = 1e-05
Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 2/69 (2%)
Query: 463 NDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFH 521
N C+ C +GG C + + C CP G+ CE E C SPC G C+ + GF
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 522 CHCPQGFSG 530
C F+G
Sbjct: 948 CIANAVFNG 956
Score = 46.6 bits (109), Expect = 1e-04
Identities = 27/81 (33%), Positives = 33/81 (40%), Gaps = 1/81 (1%)
Query: 746 TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV 805
T A ++SC NPC NGG C FSC C G+ C C PC +G C
Sbjct: 882 TQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQ 940
Query: 806 DGVNWFRCECAPGFAGPDCRI 826
+ F C F G +I
Sbjct: 941 PVLQGFECIANAVFNGQSGQI 961
Score = 46.6 bits (109), Expect = 1e-04
Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 1/71 (1%)
Query: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
+ C PC NGG C D F C CP+ G+ C+ C PC +C ++ F
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 698 CACDDGWKGKT 708
C + + G++
Sbjct: 948 CIANAVFNGQS 958
Score = 46.6 bits (109), Expect = 1e-04
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 2/70 (2%)
Query: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
C + C NGG C+ D F C+CP G C + C +PC +G C F C
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQ--WCGFSPCPHGAQCQPVLQGFEC 948
Query: 776 ICRDGWEGRT 785
I + G++
Sbjct: 949 IANAVFNGQS 958
Score = 45.4 bits (106), Expect = 3e-04
Identities = 21/71 (29%), Positives = 31/71 (43%), Gaps = 1/71 (1%)
Query: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 735
N C +PCH+ G C+ +DF C+C GK C ++ C C +G C F
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQW-CGFSPCPHGAQCQPVLQGFE 947
Query: 736 CACPPGWKGST 746
C + G +
Sbjct: 948 CIANAVFNGQS 958
Score = 44.7 bits (104), Expect = 6e-04
Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 5/58 (8%)
Query: 826 INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+ ++ C S+PC +G C D + Y CSCP G +G C+ I C+S P HG+
Sbjct: 1138 LQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNID---ECFS--NPCIHGN 1190
Score = 43.1 bits (100), Expect = 0.002
Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 6/55 (10%)
Query: 829 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+ C+S+PC G C + + CSCP +G C+EV W +P PHG+
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEV------QWCGFSPCPHGA 937
Score = 42.0 bits (97), Expect = 0.004
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 4/47 (8%)
Query: 540 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR----EPCPGGA 582
C+ +PC NG C++ D+ C+CP GK C + PCP GA
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGA 937
Score = 41.2 bits (95), Expect = 0.006
Identities = 20/70 (28%), Positives = 30/70 (42%), Gaps = 2/70 (2%)
Query: 425 NECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR-GQCQHGGTCKDLVNGYQ 483
N C+ PC N C + + C C G C V C C HG C+ ++ G++
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 484 CVCPRGFGGR 493
C+ F G+
Sbjct: 948 CIANAVFNGQ 957
Score = 38.1 bits (87), Expect = 0.052
Identities = 15/34 (44%), Positives = 18/34 (52%)
Query: 538 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
D CE PC++ RC NL Y C C + G NC
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 38.1 bits (87), Expect = 0.052
Identities = 31/123 (25%), Positives = 46/123 (37%), Gaps = 15/123 (12%)
Query: 554 LEGDYYCACPDDFGGKNCSVPREPCPGGAC-------RVIDGCGSDAGPGMPGTAASGVC 606
L G ++ C D N ++ P P V GC D + S C
Sbjct: 843 LNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGD------NSCKSNPC 896
Query: 607 GPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW 666
G C S+ +FSC C + +G C E + C PC +G C + F C + +
Sbjct: 897 HNGGVCHSR-WDDFSCSCPALTSGKACEE-VQWCGFSPCPHGAQCQPVLQGFECIANAVF 954
Query: 667 EGE 669
G+
Sbjct: 955 NGQ 957
Score = 36.6 bits (83), Expect = 0.15
Identities = 14/37 (37%), Positives = 20/37 (54%)
Query: 497 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 533
+ +D C S PC S G C +L + C C + + GP C
Sbjct: 671 VRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 34.7 bits (78), Expect = 0.58
Identities = 14/32 (43%), Positives = 18/32 (56%)
Query: 427 CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC 458
CE +PC + C NL Y CDC ++G NC
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 34.7 bits (78), Expect = 0.58
Identities = 13/32 (40%), Positives = 17/32 (53%)
Query: 678 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTC 709
C PC SRGRC +L + C C ++G C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 32.7 bits (73), Expect = 2.2
Identities = 11/32 (34%), Positives = 16/32 (50%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTC 382
C S PC + G C + ++C C + GP C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 32.3 bits (72), Expect = 2.9
Identities = 14/42 (33%), Positives = 18/42 (42%)
Query: 829 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGR 870
D C+S PC C++ Y+C C GP C GR
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGR 715
Score = 32.0 bits (71), Expect = 3.8
Identities = 13/34 (38%), Positives = 20/34 (58%)
Query: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671
D C QPC++ G CI+ +++C C +EG C
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 31.2 bits (69), Expect = 6.4
Identities = 11/34 (32%), Positives = 17/34 (50%)
Query: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
D C S PC + G C++ ++C C + G C
Sbjct: 674 DWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 30.8 bits (68), Expect = 8.4
Identities = 11/32 (34%), Positives = 15/32 (46%)
Query: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTC 786
C PC + G C+ S+ C C +EG C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 301 bits (772), Expect = 2e-81
Identities = 195/609 (32%), Positives = 261/609 (42%), Gaps = 99/609 (16%)
Query: 276 CVPYPGCVHGSCVEP-------WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP 328
C P C HG+ P ++C C + G C+ D++ C S PC +G TC N
Sbjct: 71 CATQP-CHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASR-PCHHGATCRNLA- 127
Query: 329 DQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE 388
D+Y C CP GY+G CE C S PC +GGSC + F C C G+ G C LD+DE
Sbjct: 128 DRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDE 187
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQ-WVGATCQLDANECEGKPCLNAFSCKNLIGGYYC 447
C S PCA GGTC D V+GF C C + G C+ + EC PC + SC +G + C
Sbjct: 188 CQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRC 247
Query: 448 DCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVN---------------------GYQCV 485
C PG+ G C ++ ++C CQHGG C + G+ C
Sbjct: 248 LCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCH 307
Query: 486 CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPC 545
CP GF G C +E DECAS PC +GG C+DL +GF CHCP G++GP CE DVD C PC
Sbjct: 308 CPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPC 367
Query: 546 RNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGV 605
+G C + Y C CP+ +GG++CSV C G C + C +P SGV
Sbjct: 368 LHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATC-------IP-IFESGV 419
Query: 606 CGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL--GQPCRNG---GTCIDEVDAFRC 660
++ C C G G +C +N + G P + G + FR
Sbjct: 420 ------------HSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRT 467
Query: 661 FCPSGWEGELCDTNPND-----------------------CLPDPCHSRGRCYDLVNDFY 697
P+G DT + LPD + G + + +
Sbjct: 468 TLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLH 527
Query: 698 CACDDGWKGKTCHSREFQ--CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC 755
A T R + C A C G + P G + A + C
Sbjct: 528 LA--------TLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGDATFAGC 579
Query: 756 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCEC 815
L + V+G + + + G E R C PLPC +GG CVD FRC+C
Sbjct: 580 LQDVRVDGHLLLPEDLGENVLL--GCERR------EQCRPLPCVHGGSCVDLWTHFRCDC 631
Query: 816 APGFAGPDC 824
A GP C
Sbjct: 632 ARPHRGPTC 640
Score = 287 bits (735), Expect = 4e-77
Identities = 141/426 (33%), Positives = 193/426 (45%), Gaps = 54/426 (12%)
Query: 278 PYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ--YRCTC 335
P C C +C T GG C + PC +G C+ PD +RC C
Sbjct: 38 PPSACASDPCAPGTECQA-TESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYC 96
Query: 336 PDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCA 395
G+ G CE C S PC +G +C + +ECHCP G++G TC +++DECAS PC
Sbjct: 97 VPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCL 156
Query: 396 AGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCI-PGWK 454
GG+C+D V F C+C + G CQLD +EC+ +PC + +C +L+ G+ CDC G++
Sbjct: 157 HGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYE 216
Query: 455 GINCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLC 513
G +C V +C C+H +C + + ++C+C G+ G CE++ DECASSPC GG C
Sbjct: 217 GTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRC 276
Query: 514 EDLAD---------------------GFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY 552
+D GF CHCP GF G C V+VD C PC NG C
Sbjct: 277 LQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQ 336
Query: 553 NLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRC 612
+L + C CPD + G C + C C HG
Sbjct: 337 DLPNGFQCHCPDGYAGPTCEEDVDECLSDPCL------------------------HGGT 372
Query: 613 VSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCI----DEVDAFRCFCPSGWEG 668
S + C C + G C + C G C TCI V ++ C CP G G
Sbjct: 373 CSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHG 432
Query: 669 ELCDTN 674
C N
Sbjct: 433 PFCGQN 438
Score = 278 bits (711), Expect = 2e-74
Identities = 138/402 (34%), Positives = 183/402 (45%), Gaps = 55/402 (13%)
Query: 491 GGRHC-ELERDECASSPCHSGGLCEDLAD---GFHCHCPQGFSGPLCEVDVDLCEPSPCR 546
GG C +E CA+ PCH G LC GF C+C GF GP CE+D+D C PC
Sbjct: 59 GGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCH 118
Query: 547 NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVC 606
+GA C NL Y C CP + G C + + C C
Sbjct: 119 HGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCL---------------------- 156
Query: 607 GPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCP-SG 665
HG G+F C+C G+ GT C ++D+C QPC +GGTC D V+ FRC C +G
Sbjct: 157 --HGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTG 214
Query: 666 WEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGG 725
+EG C+ +C PC C + + F C C G+ G+ C E +C + C +GG
Sbjct: 215 YEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGG 274
Query: 726 TCYDSGDT---------------------FRCACPPGWKGSTCAVAKNSSCLPNPCVNGG 764
C D F C CPPG++G+ C V + C PC+NGG
Sbjct: 275 RCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDE-CASRPCLNGG 333
Query: 765 TCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDC 824
C F C C DG+ G TC + ++C PC +GG C D V + C C + G DC
Sbjct: 334 HCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDC 393
Query: 825 RINIDECQSSPCAYGATCV----DEINGYRCSCPPGRAGPRC 862
+ + CQ C ATC+ ++ Y C CPPG GP C
Sbjct: 394 SVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFC 435
Score = 250 bits (639), Expect = 5e-66
Identities = 139/410 (33%), Positives = 188/410 (45%), Gaps = 58/410 (14%)
Query: 427 CEGKPCLNAFSCKNL-IGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDL---VNG 481
C PC C+ GGY C + C Q C HG C G
Sbjct: 42 CASDPCAPGTECQATESGGYTCG----------PMEPRGCATQPCHHGALCVPQGPDPTG 91
Query: 482 YQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE 541
++C C GF G CEL+ DECAS PCH G C +LAD + CHCP G++G CE++VD C
Sbjct: 92 FRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECA 151
Query: 542 PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP------GGACR-VIDGCGSD-A 593
+PC +G C + G + C C +GG C + + C GG C +++G D A
Sbjct: 152 SAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCA 211
Query: 594 GPGMPGT--------AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPC 645
G G GT AS C + C+ + G+F C+C G++G C + D+C PC
Sbjct: 212 GTGYEGTHCEREVLECASAPCEHNASCL-EGLGSFRCLCWPGYSGELCEVDEDECASSPC 270
Query: 646 RNGGTCIDEVD---------------------AFRCFCPSGWEGELCDTNPNDCLPDPCH 684
++GG C+ D F C CP G+EG C ++C PC
Sbjct: 271 QHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCL 330
Query: 685 SRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKG 744
+ G C DL N F C C DG+ G TC +C + C +GGTC D+ + C CP W G
Sbjct: 331 NGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGG 390
Query: 745 STCAVAKNSSCLPNPCVNGGTCVG---SGA-SFSCICRDGWEGRTCTHNT 790
C+V + + C + C TC+ SG S+ C C G G C NT
Sbjct: 391 RDCSV-QLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNT 439
Score = 232 bits (592), Expect = 1e-60
Identities = 131/386 (33%), Positives = 177/386 (45%), Gaps = 48/386 (12%)
Query: 576 EPC-PGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ---PGGNFSCICDSGFTGT 631
+PC PG C+ + G GP P A+ C CV Q P G F C C GF G
Sbjct: 45 DPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTG-FRCYCVPGFQGP 103
Query: 632 YCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 691
C +ID+C +PC +G TC + D + C CP G+ G C+ ++C PC G C D
Sbjct: 104 RCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLD 163
Query: 692 LVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACP-PGWKGSTCAVA 750
V F C C G+ G C +C + C++GGTC+D + FRC C G++G+ C
Sbjct: 164 GVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCE-R 222
Query: 751 KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVD---- 806
+ C PC + +C+ SF C+C G+ G C + ++C PC +GG C+
Sbjct: 223 EVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDP 282
Query: 807 ----GVN-------------WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 849
GV F C C PGF G DC + +DEC S PC G C D NG+
Sbjct: 283 ALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGF 342
Query: 850 RCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLD--GRRDCSKVW 905
+C CP G AGP C+E + C S P HG + + CRC + G RDCS
Sbjct: 343 QCHCPDGYAGPTCEEDVD---ECLS--DPCLHGGTCSDTVAGYICRCPETWGGRDCSVQL 397
Query: 906 CGWKPCLLAGQPEALSAQCPLGQRCL 931
G + CPL C+
Sbjct: 398 TGCQ-----------GHTCPLAATCI 412
Score = 170 bits (431), Expect = 7e-42
Identities = 116/341 (34%), Positives = 151/341 (44%), Gaps = 60/341 (17%)
Query: 675 PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ-CDAYTCSNGGTCYDSGDT 733
P+ C DPC C A + G G TC E + C C +G C G
Sbjct: 39 PSACASDPCAPGTECQ--------ATESG--GYTCGPMEPRGCATQPCHHGALCVPQGPD 88
Query: 734 ---FRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNT 790
FRC C PG++G C + + C PC +G TC + C C G+ G TC
Sbjct: 89 PTGFRCYCVPGFQGPRCELDIDE-CASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEV 147
Query: 791 NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYR 850
++C PC +GG C+DGV FRC CAPG+ G C++++DECQS PCA+G TC D +NG+R
Sbjct: 148 DECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFR 207
Query: 851 CSCP-PGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWK 909
C C G G C+ + C S P H +S +E S RCL W G+
Sbjct: 208 CDCAGTGYEGTHCEREV---LECAS--APCEHNASCLEGLGSFRCL--------CWPGYS 254
Query: 910 PCLL-AGQPEALSAQCPLGQRCLEKA------------PGQ----------CLRPPCEAW 946
L + E S+ C G RCL+++ PG C PP
Sbjct: 255 GELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEG 314
Query: 947 GECGAE--EPPSTPCLPRSGHLDNNCARLTLHFNRDHVPQG 985
+CG E E S PCL GH C L F + H P G
Sbjct: 315 ADCGVEVDECASRPCL-NGGH----CQDLPNGF-QCHCPDG 349
Score = 107 bits (268), Expect = 5e-23
Identities = 63/182 (34%), Positives = 77/182 (42%), Gaps = 23/182 (12%)
Query: 502 CASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCY-NLEGDYYC 560
CA SPC G C DL D F C C G+ GP CE VD C +PC G RC+ + +G + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFEC 1118
Query: 561 ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 620
CP FGG C R P P C + C + G+ G P N
Sbjct: 1119 RCPPGFGGPRC---RLPVPSKECSLNVTC-------LDGSPCEG---------GSPAANC 1159
Query: 621 SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680
SC+ G G C C PC NGGTC C C + + G+ C+ LP
Sbjct: 1160 SCL--EGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLP 1217
Query: 681 DP 682
P
Sbjct: 1218 LP 1219
Score = 106 bits (265), Expect = 1e-22
Identities = 51/151 (33%), Positives = 65/151 (43%), Gaps = 2/151 (1%)
Query: 678 CLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCA 737
C P PC G C DL + F CAC GW+G C + C + C+ G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 738 CPPGWKGSTC--AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 795
CPPG+ G C V L C++G C G + +C C +G G+ C T C
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 796 LPCYNGGICVDGVNWFRCECAPGFAGPDCRI 826
PC NGG C C C F+G C +
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 106 bits (264), Expect = 2e-22
Identities = 53/154 (34%), Positives = 73/154 (47%), Gaps = 6/154 (3%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG-FEC 409
C +PC + G+C ++ F C C GW GP C +D C S PCA G C DG FEC
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCAR-GRCHTHPDGRFEC 1118
Query: 410 ICPEQWVGATCQL--DANECE-GKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR 466
CP + G C+L + EC CL+ C+ C C+ G G C + C
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 467 GQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELER 499
C +GGTC+ +C+C F G+ CE+ +
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEVAK 1212
Score = 105 bits (262), Expect = 3e-22
Identities = 53/153 (34%), Positives = 74/153 (48%), Gaps = 4/153 (2%)
Query: 427 CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNG-YQCV 485
C PCL+ +C++L + C C PGW+G C +V+ C G C +G ++C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 486 CPRGFGGRHCELE--RDECASS-PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEP 542
CP GFGG C L EC+ + C G CE + +C C +G +G C+V CE
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 543 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 575
+PC NG C G C C F G+ C V +
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEVAK 1212
Score = 100 bits (250), Expect = 7e-21
Identities = 55/149 (36%), Positives = 67/149 (44%), Gaps = 6/149 (4%)
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSG-FECHCP 374
PC + G C + D + C C G+ G CE C S PCA G CH P G FEC CP
Sbjct: 1064 PCLHDGACRDLF-DAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFECRCP 1121
Query: 375 SGWSGPTCALDI--DECASN-PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKP 431
G+ GP C L + EC+ N C G C C C E G CQ+ CE P
Sbjct: 1122 PGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANP 1181
Query: 432 CLNAFSCKNLIGGYYCDCIPGWKGINCHI 460
CLN +C+ G C C + G C +
Sbjct: 1182 CLNGGTCRAAGGVSECICNARFSGQFCEV 1210
Score = 99.4 bits (246), Expect = 2e-20
Identities = 51/160 (31%), Positives = 66/160 (41%), Gaps = 4/160 (2%)
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCD 448
CA +PC G C D D F C C W G C+ + C PC + G + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 449 CIPGWKGINCHINV--NDC--RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 504
C PG+ G C + V +C C G C+ C C G G+ C++ C +
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEA 1179
Query: 505 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP 544
+PC +GG C C C FSG CEV L P P
Sbjct: 1180 NPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLP 1219
Score = 89.0 bits (219), Expect = 3e-17
Identities = 42/112 (37%), Positives = 54/112 (48%), Gaps = 3/112 (2%)
Query: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 814
C P+PC++ G C +F+C C GWEG C + + C+ PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 815 CAPGFAGPDCRINI--DECQ-SSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863
C PGF GP CR+ + EC + C G+ C CSC G AG RCQ
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQ 1171
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/155 (30%), Positives = 63/155 (40%), Gaps = 4/155 (2%)
Query: 716 CDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSC 775
C C + G C D D F CAC PGW+G C A C PC G F C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCE-AHVDPCHSAPCARGRCHTHPDGRFEC 1118
Query: 776 ICRDGWEGRTCTHN--TNDCN-PLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ 832
C G+ G C + +C+ + C +G C G C C G AG C++ C+
Sbjct: 1119 RCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCE 1178
Query: 833 SSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG 867
++PC G TC C C +G C+ G
Sbjct: 1179 ANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKG 1213
Score = 83.6 bits (205), Expect = 1e-15
Identities = 58/192 (30%), Positives = 72/192 (37%), Gaps = 12/192 (6%)
Query: 577 PCPGGACRVIDGCGSDAGPGMP--GTAASGVCGP----HGRCVSQPGGNFSCICDSGFTG 630
P PG A + S G P G + VC P H F+C C G+ G
Sbjct: 1029 PRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEG 1088
Query: 631 TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC--DTNPNDC-LPDPCHSRG 687
C ++D C PC G F C CP G+ G C +C L C
Sbjct: 1089 PRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGS 1148
Query: 688 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747
C C+C +G G+ C C+A C NGGTC +G C C + G C
Sbjct: 1149 PCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Query: 748 AVAKNSSCLPNP 759
VAK LP P
Sbjct: 1209 EVAKG---LPLP 1217
Score = 83.6 bits (205), Expect = 1e-15
Identities = 46/132 (34%), Positives = 60/132 (45%), Gaps = 14/132 (10%)
Query: 793 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCS 852
C P PC + G C D + F C C PG+ GP C ++D C S+PCA G + C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 853 CPPGRAGPRCQ-----EVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSK 903
CPPG GPRC+ + +C G+P GS +C CL+G R
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLD-GSPCEGGS----PAANCSCLEGLAGQRCQVPT 1174
Query: 904 VWCGWKPCLLAG 915
+ C PCL G
Sbjct: 1175 LPCEANPCLNGG 1186
Score = 79.3 bits (194), Expect = 2e-14
Identities = 47/174 (27%), Positives = 63/174 (36%), Gaps = 27/174 (15%)
Query: 539 LCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMP 598
+C PSPC + C +L + CAC + G C +PC C
Sbjct: 1059 VCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPC--------------- 1103
Query: 599 GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENI--DDC-LGQPCRNGGTCIDEV 655
GRC + P G F C C GF G C + +C L C +G C
Sbjct: 1104 ---------ARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGS 1154
Query: 656 DAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTC 709
A C C G G+ C C +PC + G C C C+ + G+ C
Sbjct: 1155 PAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFC 1208
Score = 64.7 bits (156), Expect = 5e-10
Identities = 47/151 (31%), Positives = 64/151 (42%), Gaps = 24/151 (15%)
Query: 299 WGGLL--CDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK---AEHACTS 353
WGG C +DL G H P +++P + G N +E C+
Sbjct: 759 WGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSEL-----GGRQSWNLTAGCVSEDMCSP 813
Query: 354 NPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPE 413
+PC NGG+C + F C CP+ ++GPTCA + C PC TC + DGF C+
Sbjct: 814 DPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVA-- 870
Query: 414 QWVGATCQLDANECEGKPCLNAFSCKNLIGG 444
+A EG P AFS N G
Sbjct: 871 ---------EATFREGPPA--AFSGHNASSG 890
Score = 55.8 bits (133), Expect = 2e-07
Identities = 43/130 (33%), Positives = 52/130 (40%), Gaps = 18/130 (13%)
Query: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCT-VPG--ECRCSYGWQGRFC----DECVPYPG 281
C G+ G +C V C L G C +P +C C G+ G C DEC+ P
Sbjct: 308 CPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDP- 366
Query: 282 CVHG----SCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCI---NAEPDQYRCT 334
C+HG V + C C WGG C L C H C TCI + Y C
Sbjct: 367 CLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGC-QGHTCPLAATCIPIFESGVHSYVCH 425
Query: 335 CPDGYSGRNC 344
CP G G C
Sbjct: 426 CPPGTHGPFC 435
Score = 55.8 bits (133), Expect = 2e-07
Identities = 26/74 (35%), Positives = 35/74 (47%), Gaps = 1/74 (1%)
Query: 778 RDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCA 837
R W + + C+P PC+NGG C+ N F C C F GP C + C PC
Sbjct: 796 RQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCL 854
Query: 838 YGATCVDEINGYRC 851
ATC + +G+ C
Sbjct: 855 PPATCEEVPDGFVC 868
Score = 54.3 bits (129), Expect = 7e-07
Identities = 28/87 (32%), Positives = 36/87 (41%), Gaps = 9/87 (10%)
Query: 497 LERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEG 556
+ D C+ PC +GG C + FHC CP F+GP C + C PC A C +
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPD 864
Query: 557 DYYCAC--------PDDFGGKNCSVPR 575
+ C P F G N S R
Sbjct: 865 GFVCVAEATFREGPPAAFSGHNASSGR 891
Score = 53.1 bits (126), Expect = 2e-06
Identities = 76/289 (26%), Positives = 95/289 (32%), Gaps = 55/289 (19%)
Query: 469 CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGF 528
C HGG+C DL ++C C R G C DE ++ GG A Q
Sbjct: 614 CVHGGSCVDLWTHFRCDCARPHRGPTCA---DEIPAATFGLGG-----APSSASFLLQEL 665
Query: 529 SGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVP----REPCPGGACR 584
GP V L R G D G + R PG
Sbjct: 666 PGPNLTVSFLL----------RTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAV 715
Query: 585 VIDGCGSDAGPGMP----GTAASGVCGPH----GRCV---SQP-GGNF-SCICDSGFTGT 631
V+ G D + G G H GR + SQP GG F C+ D G
Sbjct: 716 VLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDG- 774
Query: 632 YCHENID----DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 687
CH D QP GG W + + C PDPC + G
Sbjct: 775 -CHLPFFPLPLDNSSQPSELGGR-------------QSWNLTAGCVSEDMCSPDPCFNGG 820
Query: 688 RCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC 736
C NDF+C C + G TC +++ C C TC + D F C
Sbjct: 821 TCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFVC 868
Score = 53.1 bits (126), Expect = 2e-06
Identities = 47/151 (31%), Positives = 59/151 (39%), Gaps = 29/151 (19%)
Query: 216 DFFGHYTCDQYGNKACMDGWMGKECK-------EAVCKQG-CNLLHGGCTVPGECRCSYG 267
D F + C AC GW G C+ A C +G C+ G ECRC G
Sbjct: 1073 DLFDAFAC------ACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRF---ECRCPPG 1123
Query: 268 WQGRFC------DECVPYPGCVHGSCVEPWQ----CNCETNWGGLLCDKDLNYCGSHHPC 317
+ G C EC C+ GS E C+C G C C ++ PC
Sbjct: 1124 FGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEAN-PC 1182
Query: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEKAE 348
NGGTC A C C +SG+ CE A+
Sbjct: 1183 LNGGTC-RAAGGVSECICNARFSGQFCEVAK 1212
Score = 48.9 bits (115), Expect = 3e-05
Identities = 27/83 (32%), Positives = 35/83 (42%), Gaps = 6/83 (7%)
Query: 713 EFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 772
E C C NGGTC + + F C CP + G TC A+ C PC+ TC
Sbjct: 808 EDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC--AQQLWCPGQPCLPPATCEEVPDG 865
Query: 773 FSCIC----RDGWEGRTCTHNTN 791
F C+ R+G HN +
Sbjct: 866 FVCVAEATFREGPPAAFSGHNAS 888
Score = 45.8 bits (107), Expect = 3e-04
Identities = 22/68 (32%), Positives = 28/68 (41%), Gaps = 1/68 (1%)
Query: 746 TCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV 805
T C P+PC NGGTC+ + F C C + G TC C PC C
Sbjct: 802 TAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCE 860
Query: 806 DGVNWFRC 813
+ + F C
Sbjct: 861 EVPDGFVC 868
Score = 45.8 bits (107), Expect = 3e-04
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
D C PC NGGTC+ + F C CP+ + G C C PC C ++ + F
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPDGFV 867
Query: 698 CACD 701
C +
Sbjct: 868 CVAE 871
Score = 42.4 bits (98), Expect = 0.003
Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 344 CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
CE+ E C PC +GGSC ++ + F C C GPTCA +I
Sbjct: 603 CERREQ-CRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 40.8 bits (94), Expect = 0.008
Identities = 17/53 (32%), Positives = 24/53 (45%), Gaps = 6/53 (11%)
Query: 826 INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP 878
++ D C PC G TC+ N + C+CP GP C + + W G P
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL------WCPGQP 852
Score = 39.7 bits (91), Expect = 0.018
Identities = 14/38 (36%), Positives = 21/38 (55%)
Query: 829 DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
++C+ PC +G +CVD +RC C GP C + I
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 39.3 bits (90), Expect = 0.024
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 1/43 (2%)
Query: 495 CELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDV 537
CE R++C PC GG C DL F C C + GP C ++
Sbjct: 603 CE-RREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 38.5 bits (88), Expect = 0.040
Identities = 18/40 (45%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 709 CHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 748
C RE QC C +GG+C D FRC C +G TCA
Sbjct: 603 CERRE-QCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCA 641
Score = 38.1 bits (87), Expect = 0.052
Identities = 31/100 (31%), Positives = 39/100 (39%), Gaps = 24/100 (24%)
Query: 231 CMDGWMGKECKEAV---CKQGCNLLHGGC---TVPGE-CRCSYGWQGRFCDECVPYPGCV 283
C DG+ G C+E V C LHGG TV G CRC W GR C V GC
Sbjct: 346 CPDGYAGPTCEEDVDECLSDPC--LHGGTCSDTVAGYICRCPETWGGRDCS--VQLTGCQ 401
Query: 284 HGSC-------------VEPWQCNCETNWGGLLCDKDLNY 310
+C V + C+C G C ++ +
Sbjct: 402 GHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTF 441
Score = 36.6 bits (83), Expect = 0.15
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 2/65 (3%)
Query: 427 CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCV 485
C PC N +C ++C C + G C + C GQ C TC+++ +G+ CV
Sbjct: 811 CSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCV 869
Query: 486 CPRGF 490
F
Sbjct: 870 AEATF 874
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 257 bits (656), Expect = 5e-68
Identities = 263/940 (27%), Positives = 338/940 (35%), Gaps = 227/940 (24%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHY-----------TCDQY-GNKACMDGWMGKECKEAV- 244
C E + CN+ C P D FG TCD G C G G C++
Sbjct: 542 CPEGWTGLICNETCPP--DTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCP 599
Query: 245 -------CKQGCNLLHGG-C-TVPGECRCSYGWQGRFCD-ECVPY---PGCVHG-SCVEP 290
C++ CN + G C + G C C G GRFC C P+ PGC CV+P
Sbjct: 600 KGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQP 659
Query: 291 W---------QCNCETNWGGLLCDKD--LNY----CGSHHPCTNGGTCINAEPDQYRCTC 335
C+C+ + G C + L Y C C G C + + + C
Sbjct: 660 HTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGK-RC 718
Query: 336 PDGYSGRNCEKAEHA------CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE- 388
P G+ G +C + C+S+ G CH V +C CP G +G C D E
Sbjct: 719 PAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTG--QCRCPPGRTGEDCEADCPEG 776
Query: 389 ----------------CASNPCAAGGTCVDQVDGFEC--ICPEQWVGATCQLDANECEGK 430
+P C+ G C +CP W G +CQ +
Sbjct: 777 RWGLGCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCS----- 831
Query: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVN------DCRGQCQHG---GTCKDLVNG 481
C N C G +C C PGW G +C + DC C G+C D ++G
Sbjct: 832 -CANDGHCHPATG--HCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSC-DAISG 887
Query: 482 YQCVCPRGFGGRHCELERDECASSP-------CHSGGLCEDLADGFHCHCPQGFSGPLCE 534
C+C G+ G CE + + P C G C+ ++ C CP G+ G CE
Sbjct: 888 L-CLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGA--CTCPAGWRGTFCE 944
Query: 535 -------VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP----GGAC 583
+D C GA C + G C CP G C+ E CP G C
Sbjct: 945 HACPAGFFGLDCRSACNCTAGAACDAVNGS--CLCPAGRRGPRCA---ETCPAHTYGHNC 999
Query: 584 RVIDGCGSDAGPGMPGTAASGVCGP-HGRCVSQPGG-NFSCI--CDSGFTGTYCHENIDD 639
C + A C P HG+C PG SC+ C +G G C +
Sbjct: 1000 SQACACFNGAS-----------CDPVHGQCHCAPGWMGPSCLQACPAGLYGDNCRHS--- 1045
Query: 640 CLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDP----CHSRGRCYDL--- 692
CL C+NGGTC D V C CP GW G C+ +CLP C G C +
Sbjct: 1046 CL---CQNGGTC-DPVSG-HCACPEGWAGLACE---KECLPRDVRAGCRHSGGCLNGGLC 1097
Query: 693 -VNDFYCACDDGWKGKTCHSR-------EFQCDAYTCSNGGTCYDSGDTFRCACPPGWKG 744
+ C C GW G C S E +C G C+ T C CPPG+ G
Sbjct: 1098 DPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHV--TGACRCPPGFTG 1155
Query: 745 STCAVAKNSSCLPNPCVNGGTCVGSG-----ASFSCICRDGWEGRTCTHNTND------C 793
S C A C C G A+ +C C G+ G +C C
Sbjct: 1156 SGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGC 1215
Query: 794 NPL-PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP-------CAYGATCVDE 845
L C NGG C C C GF G DC + + + P C GA C D
Sbjct: 1216 EQLCGCLNGGSCDAATG--ACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAAC-DP 1272
Query: 846 INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTP---FPHGSSWVEDCNS---CRCLDGRR 899
+ G C CPPGRAG RC+ RG P F G C + C +G
Sbjct: 1273 VTG-TCLCPPGRAGVRCE-----------RGCPQNRFGVGCEHTCSCRNGGLCHASNGSC 1320
Query: 900 DCSKVWCGWKPCLLAGQPEALSAQCPLGQRC-----LEKAPGQCLRPP------CE---- 944
C W G + C LA P A C L C E A G C P CE
Sbjct: 1321 SCGLGWTG-RHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCP 1379
Query: 945 -----------AWGECGAE-EPPSTPCLPRSGHLDNNCAR 972
W + GA +P S CL +G + C R
Sbjct: 1380 PGFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCER 1419
Score = 223 bits (567), Expect = 1e-57
Identities = 230/796 (28%), Positives = 307/796 (38%), Gaps = 167/796 (20%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCD-QYGNKACMDGWMGKECKEAV--------CKQG 248
C E + C + C P CD + G C+ G++G C++ C+
Sbjct: 773 CPEGRWGLGCQEIC-PACQHAAR--CDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTR 829
Query: 249 CNLLHGGCTVP--GECRCSYGWQG----RFCDECVPYPGCVHGSCVEPWQCNCETNWGGL 302
C+ + G P G C C+ GW G R CD P C H CNC G
Sbjct: 830 CSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWGPDCSH-------PCNCSAGHGS- 881
Query: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC 362
CD C C G E CP G+ G CE+ C C +G +C
Sbjct: 882 -CDAISGLC----LCEAGYVGPRCEQQ-----CPQGHFGPGCEQR---CQ---CQHGAAC 925
Query: 363 HEVPSGFECHCPSGWSGPTCA-------LDIDECASNPCAAGGTCVDQVDGFECICPEQW 415
V C CP+GW G C +D ++ C AG C D V+G C+CP
Sbjct: 926 DHVSGA--CTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC-DAVNG-SCLCPAGR 981
Query: 416 VGATCQLDA-------NECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC------HINV 462
G C N + C N SC + G C C PGW G +C +
Sbjct: 982 RGPRCAETCPAHTYGHNCSQACACFNGASCDPVHG--QCHCAPGWMGPSCLQACPAGLYG 1039
Query: 463 NDCRGQC--QHGGTCKDLVNGYQCVCPRGFGGRHCELE---RDECA----SSPCHSGGLC 513
++CR C Q+GGTC D V+G+ C CP G+ G CE E RD A S C +GGLC
Sbjct: 1040 DNCRHSCLCQNGGTC-DPVSGH-CACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLC 1097
Query: 514 EDLADGFHCHCPQGFSGPLCEVDV------DLC-EPSPCRNGARCYNLEGDYYCACPDDF 566
+ C CP G++G C+ + C + C GA C+++ G C CP F
Sbjct: 1098 DPHTG--RCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCPPGF 1153
Query: 567 GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDS 626
G C + CP PG G + +C G + +C C +
Sbjct: 1154 TGSGCE---QACP---------------PGSFGEDCAQMCQCPGENPACHPATGTCSCAA 1195
Query: 627 GFTGTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCPSGWEGELCDTN----- 674
G+ G C + P C NGG+C A C CP+G+ G C+
Sbjct: 1196 GYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGA--CRCPTGFLGTDCNLTCPQGR 1253
Query: 675 --PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQ------CDAYTCS--NG 724
PN C C + C C G G C Q C+ +TCS NG
Sbjct: 1254 FGPNCTHVCGCGQGAACDPVTGT--CLCPPGRAGVRCERGCPQNRFGVGCE-HTCSCRNG 1310
Query: 725 GTCYDSGDTFRCACPPGWKGSTCAVA-----KNSSC-LPNPCVNGGTCVGSGASFSCICR 778
G C+ S + C+C GW G C +A ++C L C N TC A+ +C C
Sbjct: 1311 GLCHASNGS--CSCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTC--EPATGTCRCG 1366
Query: 779 DGWEGRTCTH------NTNDCNPLP-CYNGGICVDGVNWFRCECAPGFAGPDCRINIDE- 830
G+ G+ C H + C L C +G C D ++ RC C GF G C +
Sbjct: 1367 PGFYGQACEHPCPPGFHGAGCQGLCWCQHGAPC-DPISG-RCLCPAGFHGHFCERGCEPG 1424
Query: 831 -----C-QSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ---EVIGFGRSCWSRGTPFPH 881
C Q C GA C D + G C CPPGR+G C FG SC +
Sbjct: 1425 SFGEGCHQRCDCDGGAPC-DPVTGL-CLCPPGRSGATCNLDCRRGQFGPSC-TLHCDCGG 1481
Query: 882 GSSWVEDCNSCRCLDG 897
G+ C C+DG
Sbjct: 1482 GADCDPVSGQCHCVDG 1497
Score = 221 bits (562), Expect = 4e-57
Identities = 224/757 (29%), Positives = 270/757 (35%), Gaps = 201/757 (26%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQG 248
CD ++ C+ C N GH +CD G C G++G C++ C+Q
Sbjct: 860 CDTGHWGPDCSHPC---NCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQR 916
Query: 249 CNLLHGGCT--VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDK 306
C HG V G C C GW+G FC+ P G C CNC G CD
Sbjct: 917 CQCQHGAACDHVSGACTCPAGWRGTFCEHACP-AGFFGLDCRS--ACNCT---AGAACD- 969
Query: 307 DLNYCGSHHPCTNGGTCINAEPDQYRC--TCPDGYSGRNCEKAEHACTSNPCANGGSCHE 364
NG A RC TCP G NC + AC C NG SC
Sbjct: 970 ----------AVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQ---ACA---CFNGASCDP 1013
Query: 365 VPSGFECHCPSGWSGPTC------ALDIDECA-SNPCAAGGTCVDQVDGFECICPEQWVG 417
V +CHC GW GP+C L D C S C GGTC D V G C CPE W G
Sbjct: 1014 VHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTC-DPVSG-HCACPEGWAG 1069
Query: 418 ATCQLD-------ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC----- 465
C+ + A CLN C G C C GW G C + C
Sbjct: 1070 LACEKECLPRDVRAGCRHSGGCLNGGLCDPHTG--RCLCPAGWTGDKCQ---SPCLRGWF 1124
Query: 466 ------RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE------RDECA--------SS 505
R C G C + C CP GF G CE ++CA +
Sbjct: 1125 GEACAQRCSCPPGAACHHVTGA--CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENP 1182
Query: 506 PCH-SGGLCEDLADGFH---C--HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY 559
CH + G C A G+H C CP G GP CE LC C NG C G
Sbjct: 1183 ACHPATGTC-SCAAGYHGPSCQQRCPPGRYGPGCE---QLC---GCLNGGSCDAATG--A 1233
Query: 560 CACPDDFGGKNCSVPREPCPGGA----CRVIDGCGSDAGPGMPGTAASGVCGP-HGRCVS 614
C CP F G +C++ CP G C + GCG A C P G C+
Sbjct: 1234 CRCPTGFLGTDCNL---TCPQGRFGPNCTHVCGCGQGA-----------ACDPVTGTCLC 1279
Query: 615 QPG-GNFSCI--CDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671
PG C C G C CRNGG C C C GW G C
Sbjct: 1280 PPGRAGVRCERGCPQNRFGVGCEHTCS------CRNGGLC--HASNGSCSCGLGWTGRHC 1331
Query: 672 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 731
+ AC G G CH +C +C N TC +
Sbjct: 1332 E-------------------------LACPPGRYGAACH---LEC---SCHNNSTCEPAT 1360
Query: 732 DTFRCA-----------CPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
T RC CPPG+ G+ C C C +G C S C+C G
Sbjct: 1361 GTCRCGPGFYGQACEHPCPPGFHGAGC----QGLCW---CQHGAPC--DPISGRCLCPAG 1411
Query: 781 WEGRTCTHNT------NDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 834
+ G C C+ +GG D V C C PG +G C ++ Q
Sbjct: 1412 FHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGL-CLCPPGRSGATCNLDCRRGQFG 1470
Query: 835 P-------CAYGATCVDEINGYRCSCPPGRAGPRCQE 864
P C GA C D ++G +C C G GP C+E
Sbjct: 1471 PSCTLHCDCGGGADC-DPVSG-QCHCVDGYMGPTCRE 1505
Score = 213 bits (541), Expect = 1e-54
Identities = 243/868 (27%), Positives = 307/868 (35%), Gaps = 214/868 (24%)
Query: 231 CMDGWMGKECKEAV--CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCV 288
C+D G +C C+ G L G + G C C GW G C+E P P +C
Sbjct: 511 CLDDSFGHDCSLTCDDCRNGGTCLLG---LDG-CDCPEGWTGLICNETCP-PDTFGKNC- 564
Query: 289 EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK-- 346
+ C+C+ NGGTC + C CP G SG NCE
Sbjct: 565 -SFSCSCQ----------------------NGGTCDSVTG---ACRCPPGVSGTNCEDGC 598
Query: 347 -----AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP-CAAGGTC 400
+H CAN G CH + C C G G C L A P C+ C
Sbjct: 599 PKGYYGKHCRKKCNCANRGRCHRLYGA--CLCDPGLYGRFCHLTCPPWAFGPGCSEECQC 656
Query: 401 V-------DQVDGFECICPEQWVGATCQLDANECE----GKPCLNAFSCKNLIGGYYCDC 449
V D+ DG C C + G CQ ECE G C A +C G CD
Sbjct: 657 VQPHTQSCDKRDG-SCSCKAGFRGERCQA---ECELGYFGPGCWQACTCP---VGVACDS 709
Query: 450 IPGWKGINCHINV--NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPC 507
+ G G C DC +C G G C GG C +C P
Sbjct: 710 VSGECGKRCPAGFQGEDCGQECPVG------TFGVNCSSSCSCGGAPCHGVTGQCRCPPG 763
Query: 508 HSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFG 567
+G CE CP+G G C+ ++C C++ ARC G C C F
Sbjct: 764 RTGEDCE-------ADCPEGRWGLGCQ---EIC--PACQHAARCDPETG--ACLCLPGFV 809
Query: 568 GKNCSVPREPCPGG----ACRVIDGCGSD-----------AGPGMPGTAASGVC-----G 607
G C ++ CP G +C+ C +D PG G + C G
Sbjct: 810 GSRC---QDVCPAGWYGPSCQTRCSCANDGHCHPATGHCSCAPGWTGFSCQRACDTGHWG 866
Query: 608 P-----------HGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP-------CRNGG 649
P HG C + G C+C++G+ G C + P C++G
Sbjct: 867 PDCSHPCNCSAGHGSCDAISG---LCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGA 923
Query: 650 TCIDEVDAFRCFCPSGWEGELCD-TNPNDCLPDPCHSRGRC-----YDLVNDFYCACDDG 703
C D V C CP+GW G C+ P C S C D VN C C G
Sbjct: 924 AC-DHVSG-ACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAACDAVNG-SCLCPAG 980
Query: 704 WKGKTC------HSREFQC-DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVA------ 750
+G C H+ C A C NG +C +C C PGW G +C A
Sbjct: 981 RRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHG--QCHCAPGWMGPSCLQACPAGLY 1038
Query: 751 ---KNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLP---------- 797
SCL C NGGTC S C C +GW G C +C P
Sbjct: 1039 GDNCRHSCL---CQNGGTC--DPVSGHCACPEGWAGLAC---EKECLPRDVRAGCRHSGG 1090
Query: 798 CYNGGICVDGVNWFRCECAPGFAGPDCRINI------DEC-QSSPCAYGATCVDEINGYR 850
C NGG+C RC C G+ G C+ + C Q C GA C + G
Sbjct: 1091 CLNGGLCDPHTG--RCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAAC-HHVTG-A 1146
Query: 851 CSCPPGRAGPRCQEVI---GFGRSCWSR-----GTPFPHGSSWVEDC------NSC--RC 894
C CPPG G C++ FG C P H ++ C SC RC
Sbjct: 1147 CRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRC 1206
Query: 895 LDGR--RDCSKVWCGWKPCLLAGQPEALSAQCP-----LGQRCLEKAPGQCLRPPCEAWG 947
GR C ++ CG CL G +A + C LG C P P C
Sbjct: 1207 PPGRYGPGCEQL-CG---CLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTHVC 1262
Query: 948 ECG---AEEPPSTPCLPRSGHLDNNCAR 972
CG A +P + CL G C R
Sbjct: 1263 GCGQGAACDPVTGTCLCPPGRAGVRCER 1290
Score = 190 bits (482), Expect = 8e-48
Identities = 211/764 (27%), Positives = 257/764 (33%), Gaps = 217/764 (28%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--------CKQGC 249
C +Y +C C ND H G+ +C GW G C+ A C C
Sbjct: 817 CPAGWYGPSCQTRCSCANDGHCHPAT---GHCSCAPGWTGFSCQRACDTGHWGPDCSHPC 873
Query: 250 NLL--HGGC-TVPGECRCSYGWQGRFCDECVPY----PGCV------HGSCVE--PWQCN 294
N HG C + G C C G+ G C++ P PGC HG+ + C
Sbjct: 874 NCSAGHGSCDAISGLCLCEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGACT 933
Query: 295 CETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA- 347
C W G C+ C S CT G C + C CP G G C +
Sbjct: 934 CPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC---DAVNGSCLCPAGRRGPRCAETC 990
Query: 348 -----EHACTSN-PCANGGSCHEVPSGFECHCPSGWSGPTC------ALDIDECA-SNPC 394
H C+ C NG SC V +CHC GW GP+C L D C S C
Sbjct: 991 PAHTYGHNCSQACACFNGASCDPVHG--QCHCAPGWMGPSCLQACPAGLYGDNCRHSCLC 1048
Query: 395 AAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKP-------CLNAFSCKNLIGGYYC 447
GGTC D V G C CPE W G C+ + + + CLN C G C
Sbjct: 1049 QNGGTC-DPVSG-HCACPEGWAGLACEKECLPRDVRAGCRHSGGCLNGGLCDPHTGR--C 1104
Query: 448 DCIPGWKGINCHINVNDC-----------RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
C GW G C + C R C G C + C CP GF G CE
Sbjct: 1105 LCPAGWTGDKCQ---SPCLRGWFGEACAQRCSCPPGAACHHVTGA--CRCPPGFTGSGCE 1159
Query: 497 LE------RDECA--------SSPCHSG-GLCEDLADGFH---CH--CPQGFSGPLCEVD 536
++CA + CH G C A G+H C CP G GP CE
Sbjct: 1160 QACPPGSFGEDCAQMCQCPGENPACHPATGTCS-CAAGYHGPSCQQRCPPGRYGPGCE-- 1216
Query: 537 VDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA----CRVIDGCGSD 592
LC C NG C G C CP F G +C++ CP G C + GCG
Sbjct: 1217 -QLCG---CLNGGSCDAATGA--CRCPTGFLGTDCNLT---CPQGRFGPNCTHVCGCGQG 1267
Query: 593 AG-----------PGMPGTAASGVC-------GPHGRCVSQPGG-----NFSCICDSGFT 629
A PG G C G C + GG N SC C G+T
Sbjct: 1268 AACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSCSCGLGWT 1327
Query: 630 GTYCH------------------ENIDDC-------------LGQPC------------- 645
G +C N C GQ C
Sbjct: 1328 GRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGC 1387
Query: 646 ------RNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP----DPCHSRGRC-----Y 690
++G C D + RC CP+G+ G C+ C P + CH R C
Sbjct: 1388 QGLCWCQHGAPC-DPISG-RCLCPAGFHGHFCERG---CEPGSFGEGCHQRCDCDGGAPC 1442
Query: 691 DLVNDFYCACDDGWKGKTCH----------SREFQCDAYTCSNGGTCYDSGDTFRCACPP 740
D V C C G G TC+ S CD C G C +C C
Sbjct: 1443 DPVTGL-CLCPPGRSGATCNLDCRRGQFGPSCTLHCD---CGGGADCDPVSG--QCHCVD 1496
Query: 741 GWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR 784
G+ G TC NP + G+ AS R G R
Sbjct: 1497 GYMGPTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPAR 1540
Score = 169 bits (428), Expect = 2e-41
Identities = 192/699 (27%), Positives = 258/699 (36%), Gaps = 171/699 (24%)
Query: 344 CEKAEHACTSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCALDIDECASNPCAAGGTCVD 402
C AE C+++ C +GG C VP + CHCP G+ GP C D+DEC ++ CV+
Sbjct: 123 CLSAE--CSASLCFHGGRC--VPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVN 178
Query: 403 QVDGFECICPEQW----VGATCQLDANEC------------------------------- 427
+ C C + TC L N C
Sbjct: 179 TPGSYLCECKPGFRLHTDSRTC-LAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQE 237
Query: 428 EGKPCLNAFSCKNLIGG--YYCDCIPGWKGINCHI------------NVNDCR---GQCQ 470
+G+ C+ C N G + C + G CH+ +V++C QC
Sbjct: 238 DGRHCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCA 297
Query: 471 HGGTCKDLVNGYQCVCPRGF----GGRHC-ELERDECASSPCHSGGL---CEDLADGFHC 522
HG C + ++CVC G+ GR C +E + S ++GG C + G C
Sbjct: 298 HG--CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLC 355
Query: 523 HCPQGFSGPLCE---VDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP 579
CP+G+ + +DVD C SPC C N G Y C C + G S
Sbjct: 356 TCPRGYELDTDQRTCIDVDDCADSPCCQQV-CTNNPGGYECGC---YAGYRLS-----AD 406
Query: 580 GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDD 639
G C +D C S G G C + G+F C C++G+ HE+
Sbjct: 407 GCGCEDVDECASSRG------------GCEHHCTNL-AGSFQCSCEAGYR---LHEDRRG 450
Query: 640 CLGQPCRNGGTCIDEVDAFRCFCP--SGWEGELCDTNPNDCL---PDPCHSRGRCYDLVN 694
C P +D F P + + EL +D + + RG + L
Sbjct: 451 C--SPLEEPMVDLDGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGE-HTLTE 507
Query: 695 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS 754
F C DD + H CD C NGGTC D C CP GW G C N +
Sbjct: 508 KFVC-LDDSFG----HDCSLTCD--DCRNGGTCLLGLD--GCDCPEGWTGLIC----NET 554
Query: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 814
C P+ G SFSC C++ G TC T C P +G C DG
Sbjct: 555 CPPD-------TFGKNCSFSCSCQN---GGTCDSVTGACRCPPGVSGTNCEDG------- 597
Query: 815 CAPGFAGPDCRINIDECQSSPC--AYGA-TCVDEINGYRC--SCPPGRAGPRCQEVIGFG 869
C G+ G CR + C YGA C + G C +CPP GP C E
Sbjct: 598 CPKGYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEEC--- 654
Query: 870 RSCWSRGTPFPHGSSWVEDCNSCRCLDGRR------DCSKVWCG---WKPCLLAGQPEAL 920
C PH S + SC C G R +C + G W+ C
Sbjct: 655 -QCVQ-----PHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQAC--------- 699
Query: 921 SAQCPLGQRCLEKAPGQC-LRPPCEAWGE-CGAEEPPST 957
CP+G C + G+C R P GE CG E P T
Sbjct: 700 --TCPVGVAC-DSVSGECGKRCPAGFQGEDCGQECPVGT 735
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 242 bits (617), Expect = 2e-63
Identities = 252/932 (27%), Positives = 372/932 (39%), Gaps = 206/932 (22%)
Query: 173 NPEDRWKSLHFSGHVAHLELQIRV---RCDENYYSATCNKFCRPRNDFFGHYTCD---QY 226
N ++ L + G +A ++++ + CD N + + F H +
Sbjct: 1301 NIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKK 1360
Query: 227 GNKACMDGWMGKECKEAVCKQGCNLLHGGC-TVPG--ECRCSYGWQGRFCDECVPYPGCV 283
G C D EC+ + C++ H C +PG +C C GW G +C+ C
Sbjct: 1361 GTTGCTDV---DECE--IGAHNCDM-HASCLNIPGSFKCSCREGWIGNGI-KCIDLDECS 1413
Query: 284 HGS--------CVEP---WQCNCETNW--GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ 330
+G+ CV ++C C + G C D++ C + G C+N P
Sbjct: 1414 NGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTCS-DVDECAENINLCENGQCLNV-PGA 1471
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTC 382
YRC C G++ R+C+ + N C G +C+ +P F C C G+ +G C
Sbjct: 1472 YRCECEMGFTPASDSRSCQDIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRTGGNC 1530
Query: 383 ALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLI 442
DIDECA G CV+ +EC CP + QL+ G C++ N +
Sbjct: 1531 T-DIDECADPINCVNGLCVNTPGRYECNCPPDF-----QLNPT---GVGCVD-----NRV 1576
Query: 443 GGYYCDCIP---GWKGINCHINVNDCRGQC------QHGGTCKDL--VNG--YQCVCPRG 489
G Y P G N I V R C G C+ VN Y +CP G
Sbjct: 1577 GNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGG 1636
Query: 490 FGGRHCEL-----ERDECASSP-CHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDL 539
G R + + DEC P GG C + F C CPQG+ +CE D+D
Sbjct: 1637 EGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQGYYLSEDTRICE-DIDE 1695
Query: 540 C--EPSPCRNGARCYNLEGDYYCACPDDF----GGKNC---------------------- 571
C P C G CYN G+Y C CP ++ GG NC
Sbjct: 1696 CFAHPGVCGPGT-CYNTLGNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELP 1754
Query: 572 ------------------SVPREPC--PGGA-----CRVIDGCGSDAGPG---------- 596
+ P EPC PG A C I G D G
Sbjct: 1755 FNVTKRMCCCTYNVGKAWNKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKE 1814
Query: 597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGT---YCHENIDDCLG--QPCRNGGTC 651
+PG A+GV C++Q G+F C C +GF+ E+ID+C C+ C
Sbjct: 1815 IPGICANGV------CINQI-GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867
Query: 652 IDEVDAFRCFCPSGWE----GELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG- 706
I+ ++RC C +G++ G D N +P+ C S G C DL + C C +G+K
Sbjct: 1868 INSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKAS 1926
Query: 707 --KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK---GSTCAVAKNSSCLPNPCV 761
+T +C+ + C N GTC ++ ++ C C PG++ + C S
Sbjct: 1927 QDQTMCMDVDECERHPCGN-GTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVC 1985
Query: 762 NGGTCVGSGASFSCICRDGWE----GRTCTHNTNDCNPLP-CYNGGICVDGVNWFRCECA 816
G C SF C+C +G+E G+ C +TN+C LP + G C + FRC C
Sbjct: 1986 RNGRCFNEIGSFKCLCNEGYELTPDGKNCI-DTNECVALPGSCSPGTCQNLEGSFRCICP 2044
Query: 817 PGF--AGPDCRINIDECQSSP--CAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSC 872
PG+ +C I+I+EC P C +G +C + G++C CPPG + GR C
Sbjct: 2045 PGYEVKSENC-IDINECDEDPNICLFG-SCTNTPGGFQCLCPPGFV------LSDNGRRC 2096
Query: 873 WSRGTPFPHGSSWVEDCNSCRCLDGRRD---CSKV-WCGW-KPCLLAGQPEALSAQ--CP 925
+ F + C+ + + + CSK+ GW PC L + + ++ Q CP
Sbjct: 2097 FDTRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCP 2156
Query: 926 LG--------------QRCLEKAPGQCLRPPC 943
G CLE +PG C C
Sbjct: 2157 YGHGTVPSLHDTREDVNECLE-SPGICSNGQC 2187
Score = 209 bits (531), Expect = 2e-53
Identities = 225/863 (26%), Positives = 336/863 (38%), Gaps = 185/863 (21%)
Query: 158 NEELLIERV-SHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRND 216
NE L I V SH ++ + ++ + +G A + + + DE N C+ +
Sbjct: 1894 NECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCK---N 1950
Query: 217 FFGHYTCDQYG------NKACMD-----GWMGKECKEAVCKQGCNLLHGGCTVPGECRCS 265
G Y C Y N C+D + G+ C+ C +C C+
Sbjct: 1951 TVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFNEIGSF--------KCLCN 2002
Query: 266 YGWQ----GRFC---DECVPYPG-CVHGSCVE---PWQCNCETNWGGLL--------CDK 306
G++ G+ C +ECV PG C G+C ++C C + CD+
Sbjct: 2003 EGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYEVKSENCIDINECDE 2062
Query: 307 DLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNC-EKAEHACTSNPCANGGS 361
D N C G+C N P ++C CP G+ +GR C + + C +N G
Sbjct: 2063 DPNICLF-------GSCTNT-PGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTN--FENGK 2112
Query: 362 CHEVPSGF-----ECHCPS----GWSGPTCAL---------------------------- 384
C VP F +C C GW P C L
Sbjct: 2113 C-SVPKAFNTTKAKCCCSKMPGEGWGDP-CELCPKDDEVAFQDLCPYGHGTVPSLHDTRE 2170
Query: 385 DIDECASNP-CAAGGTCVDQVDGFECICPE----QWVGATCQLDANECE-GKPCLNAFSC 438
D++EC +P + G C++ F C CP + G C +D +EC G PC N +C
Sbjct: 2171 DVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCGNG-TC 2228
Query: 439 KNLIGGYYCDCIPGWKG---INCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRH 494
N+IG + C+C G++ +NC ++N+C + C + Y+C CP G+ R
Sbjct: 2229 TNVIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCPIGYALRE 2287
Query: 495 CEL---ERDECASS--PCHSGGL-CEDLADGFHCHCPQGFS----GPLCEVDVDLCEPSP 544
+ + DECA C S G+ C++L F C CP G + G C VD + C P
Sbjct: 2288 DQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTKP 2346
Query: 545 --CRNGARCYNLEGDYYCACPDDF----GGKNCSVPREPCPGGAC--RVIDGCGSDAGPG 596
C NG RC N+ G Y C C + F G C R+ G C V+ A
Sbjct: 2347 GICENG-RCVNIIGSYRCECNEGFQSSSSGTECLDNRQ----GLCFAEVLQTICQMASSS 2401
Query: 597 MPGTAASGVCGPHGR--------CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQP--CR 646
S C GR C + IC G T +ID+C P C
Sbjct: 2402 RNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLCT 2461
Query: 647 NGGTCIDEVDAFRCFCPSGWEGELCDTNPND---CLPDPCHSRGRCYDLVNDFYCACDDG 703
NG CI+ + +FRCFC G+ ++ T+ D C P C + + C+C G
Sbjct: 2462 NG-QCINTMGSFRCFCKVGYTTDISGTSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRG 2520
Query: 704 W----KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNP 759
+ GKTC + +C + C ++ F C CPPG+ A N+ C P
Sbjct: 2521 YVLQEDGKTCKDLD-ECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQP 2579
Query: 760 CVNG--GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLP----CYNGGICVDGVNWFRC 813
+ G G C + SFSC C+ G+ N D + C +G C + + +RC
Sbjct: 2580 SLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDECDGNHRCQHG--CQNILGGYRC 2637
Query: 814 ECAPGFAGP----DCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFG 869
C G+ C ++ +EC + A+C + + Y+C+CP G +
Sbjct: 2638 GCPQGYIQHYQWNQC-VDENECSNPNACGSASCYNTLGSYKCACPSGFS----------- 2685
Query: 870 RSCWSRGTPFPHGSSWVEDCNSC 892
F SS D N C
Sbjct: 2686 ---------FDQFSSACHDVNEC 2699
Score = 204 bits (518), Expect = 6e-52
Identities = 196/723 (27%), Positives = 294/723 (40%), Gaps = 128/723 (17%)
Query: 245 CKQGCNL-LHGGCT-VPG--ECRCSYGW----QGRFC---DECVPYPGCVHGSCVEPWQC 293
C + N+ L G CT PG +C C G+ GR C + + +G C P
Sbjct: 2060 CDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFCFTNFENGKCSVPKAF 2119
Query: 294 NCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEH 349
N T C K + G PC C + ++ CP G+ S + + +
Sbjct: 2120 N--TTKAKCCCSK-MPGEGWGDPCE---LCPKDDEVAFQDLCPYGHGTVPSLHDTREDVN 2173
Query: 350 ACTSNP--CANGGSCHEVPSGFECHCPSGWS----GPTCALDIDECA-SNPCAAGGTCVD 402
C +P C+NG C F C CP G++ G C +D DEC+ NPC GTC +
Sbjct: 2174 ECLESPGICSNG-QCINTDGSFRCECPMGYNLDYTGVRC-VDTDECSIGNPCG-NGTCTN 2230
Query: 403 QVDGFECICPEQWVGA---TCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGW------ 453
+ FEC C E + C+ D NEC P L AF C N G Y C C G+
Sbjct: 2231 VIGSFECNCNEGFEPGPMMNCE-DINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQ 2289
Query: 454 ---KGIN-CHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFG----GRHCELERDECASS 505
K ++ C ++DC + G CK+L+ + C+CP G G C ++ +EC +
Sbjct: 2290 KMCKDLDECAEGLHDCESR---GMMCKNLIGTFMCICPPGMARRPDGEGC-VDENECRTK 2345
Query: 506 P--CHSGGLCEDLADGFHCHCPQGF----SGPLC-EVDVDLC----EPSPCRNGARCYNL 554
P C + G C ++ + C C +GF SG C + LC + C+ + NL
Sbjct: 2346 PGICEN-GRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNL 2404
Query: 555 EGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVS 614
C C GG+ E CP +PGTA PHG +
Sbjct: 2405 VTKSECCCD---GGRGWGHQCELCP-----------------LPGTAQYKKICPHGPGYT 2444
Query: 615 QPGGNFSCICDSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWEGELCD 672
G +ID+C P C N G CI+ + +FRCFC G+ ++
Sbjct: 2445 TDG-----------------RDIDECKVMPNLCTN-GQCINTMGSFRCFCKVGYTTDISG 2486
Query: 673 T---NPNDCLPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDAYTCSNGG 725
T + ++C P C + + C+C G+ GKTC + +C +
Sbjct: 2487 TSCIDLDECSQSPKPCNYICKNTEGSYQCSCPRGYVLQEDGKTCKDLD-ECQTKQHNCQF 2545
Query: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSSC--LPNPCVNGGTCVGSGASFSCICRDGWE- 782
C ++ F C CPPG+ A N+ C P+ C G C + SFSC C+ G+
Sbjct: 2546 LCVNTLGGFTCKCPPGFTQHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSL 2605
Query: 783 ---GRTCTHNTNDCN-PLPCYNGGICVDGVNWFRCECAPG----FAGPDCRINIDECQSS 834
G C + ++C+ C +G C + + +RC C G + C ++ +EC +
Sbjct: 2606 DATGLNC-EDVDECDGNHRCQHG--CQNILGGYRCGCPQGYIQHYQWNQC-VDENECSNP 2661
Query: 835 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRC 894
A+C + + Y+C+CP G + + C S P +G S E C C
Sbjct: 2662 NACGSASCYNTLGSYKCACPSGFSFDQFSSACHDVNECSSSKNPCNYGCSNTEGGYLCGC 2721
Query: 895 LDG 897
G
Sbjct: 2722 PPG 2724
Score = 191 bits (485), Expect = 4e-48
Identities = 201/757 (26%), Positives = 293/757 (38%), Gaps = 176/757 (23%)
Query: 229 KACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGC----VH 284
+ C+D M C + K C G EC C+ G F + C P P H
Sbjct: 695 RVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYG-FGEPCQPCPAKNSAEFH 753
Query: 285 GSCVEPWQCNCETNWGGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY---- 339
G C ++ G+ D +D+N C G C N YRC C GY
Sbjct: 754 GLC---------SSGVGITVDGRDINECALDPDICANGICENLR-GSYRCNCNSGYEPDA 803
Query: 340 SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCA 395
SGRNC + + + G C P + C CP G+ TC DI+EC SNPC
Sbjct: 804 SGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPC- 861
Query: 396 AGGTCVDQVDGFEC-------------ICPEQWVGATCQLDANE--CE---GKPCLNAFS 437
G C + + F C IC + G TC L+ + CE L +
Sbjct: 862 VNGACRNNLGSFNCECSPGSKLSSTGLICIDSLKG-TCWLNIQDSRCEVNINGATLKSEC 920
Query: 438 CKNLIGGYYCDC------------IPGWKGINCHINVNDCR---GQCQHGGTCKDLVNGY 482
C L + C + KG+ C +VN+C G C + G C + +
Sbjct: 921 CATLGAAWGSPCERCELDTACPRGLARIKGVTCE-DVNECEVFPGVCPN-GRCVNSKGSF 978
Query: 483 QCVCPRGF----GGR--------HCELERDE----------------CASSPCHSGGLCE 514
C CP G GR C L+ DE C + G CE
Sbjct: 979 HCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECE 1038
Query: 515 DL----ADGFHCHCPQG---------FSGPLCEVDVDLCE--PSPCRNGARCYNLEGDYY 559
+ + CP+G +G D++ C+ P C G +C N G +
Sbjct: 1039 ECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYG-KCRNTIGSFK 1097
Query: 560 CACPDDFG----GKNCSVPREPCPGGACRVI-DGCGSDAGPGMPGTAASGVCGPHGRCVS 614
C C F +NC+ E CR+ D CGS G CV+
Sbjct: 1098 CRCNSGFALDMEERNCTDIDE------CRISPDLCGS------------------GICVN 1133
Query: 615 QPGGNFSCIC----DSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWE- 667
P G+F C C +SGF +ID+C P CR GGTC++ +F+C CP G E
Sbjct: 1134 TP-GSFECECFEGYESGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCDCPLGHEL 1191
Query: 668 ---GELCDTNPNDC-LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSN 723
E C + N+C L D G+C +++ + C+C+ G++ D N
Sbjct: 1192 SPSREDC-VDINECSLSDNLCRNGKCVNMIGTYQCSCNPGYQATPDRQGCTDIDECMIMN 1250
Query: 724 GG---TCYDSGDTFRCACPPGW----KGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 776
GG C +S ++ C+C G+ G +CA P+ C +GG C + C+
Sbjct: 1251 GGCDTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDIC-DGGQCTNIPGEYRCL 1309
Query: 777 CRDGW----EGRTCTHNTNDCNPLPCYNGGICVDG-----VNWFRCECAPGFA---GPDC 824
C DG+ + +TC + N+C+ N IC+ G F C C G++ G
Sbjct: 1310 CYDGFMASMDMKTCI-DVNECD----LNSNICMFGECENTKGSFICHCQLGYSVKKGTTG 1364
Query: 825 RINIDECQ--SSPCAYGATCVDEINGYRCSCPPGRAG 859
++DEC+ + C A+C++ ++CSC G G
Sbjct: 1365 CTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIG 1401
Score = 182 bits (463), Expect = 1e-45
Identities = 197/750 (26%), Positives = 293/750 (39%), Gaps = 162/750 (21%)
Query: 218 FGHYTCDQYGNKACMDGWMGKECKEAVCKQ--GCNLLHGGCTVPGECRCSYGWQGRFCDE 275
FG + C+ C G+ E +C+ C H G PG C Y G +
Sbjct: 1670 FGSFQCE------CPQGYYLSE-DTRICEDIDEC-FAHPGVCGPGTC---YNTLGNYTCI 1718
Query: 276 CVPYPGCVHG--SCVEPWQCNCETNWGGLLCDKDLNY-------CGSHH----------P 316
C P V+G +C++ + C ++ G C+ +L + C +++ P
Sbjct: 1719 CPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAWNKPCEP 1778
Query: 317 CTNGGTCINAEPDQYRCTCP-------DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGF 369
C GT ++ C D ++G+ + E CANG +++ S F
Sbjct: 1779 CPTPGTA------DFKTICGNIPGFTFDIHTGKAVDIDECKEIPGICANGVCINQIGS-F 1831
Query: 370 ECHCPSGWSGPTCAL---DIDECAS--NPCAAGGTCVDQVDGFECICPEQWV---GATCQ 421
C CP+G+S L DIDEC++ N C C++ + C C + C
Sbjct: 1832 RCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPNGAC- 1890
Query: 422 LDANECEGKPCLNAFS-CKNLIGGYYCDCIPGWKGINCH---INVNDCRGQCQHGGTCKD 477
+D NEC P + + C +L G Y C C G+K ++V++C GTCK+
Sbjct: 1891 VDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGTCKN 1950
Query: 478 LVNGYQCVCPRGFGGRHCE--LERDECAS---SPCHSGGLCEDLADGFHCHCPQGF---- 528
V Y C+C GF H L+ DEC+S C + G C + F C C +G+
Sbjct: 1951 TVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN-GRCFNEIGSFKCLCNEGYELTP 2009
Query: 529 SGPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVI 586
G C +D + C P C G C NLEG + C CP + K+ + C I
Sbjct: 2010 DGKNC-IDTNECVALPGSCSPGT-CQNLEGSFRCICPPGYEVKSEN----------CIDI 2057
Query: 587 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT------------GTYCH 634
+ C D +C G C + PGG F C+C GF ++C
Sbjct: 2058 NECDED----------PNIC-LFGSCTNTPGG-FQCLCPPGFVLSDNGRRCFDTRQSFCF 2105
Query: 635 ENIDD-----------------CLGQPCRN-GGTC----IDEVDAFRCFCP--SGWEGEL 670
N ++ C P G C D+ AF+ CP G L
Sbjct: 2106 TNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDLCPYGHGTVPSL 2165
Query: 671 CDT--NPNDCLPDP-CHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSN 723
DT + N+CL P S G+C + F C C G+ G C + +C
Sbjct: 2166 HDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTD-ECSIGNPCG 2224
Query: 724 GGTCYDSGDTFRCACPPGWK-GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 782
GTC + +F C C G++ G + C NP + C+ + S+ C C G+
Sbjct: 2225 NGTCTNVIGSFECNCNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYA 2284
Query: 783 GR----------TCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINI 828
R C +DC G +C + + F C C PG A G C ++
Sbjct: 2285 LREDQKMCKDLDECAEGLHDCES----RGMMCKNLIGTFMCICPPGMARRPDGEGC-VDE 2339
Query: 829 DECQSSP--CAYGATCVDEINGYRCSCPPG 856
+EC++ P C G CV+ I YRC C G
Sbjct: 2340 NECRTKPGICENG-RCVNIIGSYRCECNEG 2368
Score = 182 bits (461), Expect = 2e-45
Identities = 219/790 (27%), Positives = 306/790 (38%), Gaps = 177/790 (22%)
Query: 225 QYGNKACMDGWMGKECKEAVCKQGCNLLHGGCT-VPGE--CRCSYGWQG----RFC---D 274
Q N C+D EC C +G C PG C+C G+Q + C D
Sbjct: 527 QDANGDCIDV---DECTSNPCT------NGDCVNTPGSYYCKCHAGFQRTPTKQACIDID 577
Query: 275 ECVPYPG-CVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA---- 326
EC+ C +G CV +QC C G D C H CT C+N
Sbjct: 578 ECIQNGVLCKNGRCVNTDGSFQCICNA---GFELTTDGKNCVDHDECTTTNMCLNGMCIN 634
Query: 327 EPDQYRCTCPDGY----SGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWS-GPT 381
E ++C C G+ +GR C + T C NG C F C CP G + G
Sbjct: 635 EDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNG-HCINSEGSFRCDCPPGLAVGMD 693
Query: 382 CALDIDECASNPCAAG---GTCVDQVDGF----ECIC--PEQWVGATCQ----------- 421
+ +D + C G G CV G EC C P+ G CQ
Sbjct: 694 GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFH 753
Query: 422 -------------LDANECEGKP--CLNAFSCKNLIGGYYCDCIPGWK----GINCHINV 462
D NEC P C N C+NL G Y C+C G++ G NC I++
Sbjct: 754 GLCSSGVGITVDGRDINECALDPDICANGI-CENLRGSYRCNCNSGYEPDASGRNC-IDI 811
Query: 463 NDC---RGQCQHGGTCKDLVNGYQCVCPRGFGGRH----CELERDECASSPCHSGGLCED 515
++C R C +G C++ Y C CP G+ R CE + +EC S+PC +G C +
Sbjct: 812 DECLVNRLLCDNG-LCRNTPGSYSCTCPPGYVFRTETETCE-DINECESNPCVNGA-CRN 868
Query: 516 LADGFHCHCPQGF----SGPLCEVDVDLCEPSPCRN--GARC-YNLEG----DYYCACPD 564
F+C C G +G +C +D + + N +RC N+ G CA
Sbjct: 869 NLGSFNCECSPGSKLSSTGLIC---IDSLKGTCWLNIQDSRCEVNINGATLKSECCATLG 925
Query: 565 DFGGKNCSVPR--EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC 622
G C CP G R+ D GVC P+GRCV+ G +F C
Sbjct: 926 AAWGSPCERCELDTACPRGLARIKGVTCEDVNEC---EVFPGVC-PNGRCVNSKG-SFHC 980
Query: 623 ICDSGFT--GT------------YCHENIDDCLGQP----------CRNG---GTCIDE- 654
C G T GT Y + D+C+ C G GT +E
Sbjct: 981 ECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKFRMDACCCAVGAAWGTECEEC 1040
Query: 655 ----VDAFRCFCPSGW----EGELCDTNP-----NDC--LPDPCHSRGRCYDLVNDFYCA 699
+ CP G G++ P N+C P C + G+C + + F C
Sbjct: 1041 PKPGTKEYETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMC-TYGKCRNTIGSFKCR 1099
Query: 700 CDDGW----KGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKN--- 752
C+ G+ + + C + + G C ++ +F C C G++ S + KN
Sbjct: 1100 CNSGFALDMEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYE-SGFMMMKNCMD 1158
Query: 753 -SSCLPNPCV-NGGTCVGSGASFSCICRDGWE---GRTCTHNTNDCNPLP--CYNGGICV 805
C NP + GGTCV + SF C C G E R + N+C+ C NG CV
Sbjct: 1159 IDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGK-CV 1217
Query: 806 DGVNWFRCECAPGF-AGPDCR--INIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRC 862
+ + ++C C PG+ A PD + +IDEC C + Y CSC G A
Sbjct: 1218 NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYA---- 1273
Query: 863 QEVIGFGRSC 872
++ GRSC
Sbjct: 1274 --LMPDGRSC 1281
Score = 163 bits (413), Expect = 8e-40
Identities = 233/914 (25%), Positives = 332/914 (36%), Gaps = 198/914 (21%)
Query: 167 SHAGMINPEDRWKSLHFSGHVAHLELQIRVR----CDENYYSATC---------NKFCRP 213
S G + PE R + + V Q +R C ++S C N+ P
Sbjct: 54 SEGGFLAPEYREEGAAVASRVRRRGQQDVLRGPNVCGSRFHSYCCPGWKTLPGGNQCIVP 113
Query: 214 --RNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNL--LHGGCTVPGECRCSYGWQ 269
RN G C + C G + C +Q C++ ++GG C+C G+
Sbjct: 114 ICRNSC-GDGFCSRPNMCTCSSGQISSTCGSKSIQQ-CSVRCMNGGTCADDHCQCQKGYI 171
Query: 270 GRFCDECVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP 328
G +C + V GC +G C+ P +C C + G C++D G C
Sbjct: 172 GTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDY----------RTGPCFTQVN 221
Query: 329 DQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPS-------GFECHCPSGWSGPT 381
+Q C +G C K C + A G C P+ GF + +G
Sbjct: 222 NQ---MCQGQLTGIVCTKT-LCCATIGRAWGHPCEMCPAQPQPCRRGFIPNIRTG----- 272
Query: 382 CALDIDECASNP-CAAGGTCVDQVDGFECICP----EQWVGATCQLDANECEGKPCL-NA 435
D+DEC + P GG C++ V FEC CP + C+ D +EC P +
Sbjct: 273 ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCE-DIDECSIIPGICET 331
Query: 436 FSCKNLIGGYYCDCIPGW----KGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFG 491
C N +G Y+C C G+ G C ++ G C G LVNG C +
Sbjct: 332 GECSNTVGSYFCVCPRGYVTSTDGSRC---IDQRTGMCFSG-----LVNGR---CAQELP 380
Query: 492 GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARC 551
GR + + +C P G C + + E P R
Sbjct: 381 GR---MTKMQCCCEP----GRCWGIG--------------------TIPEACPVRGSE-- 411
Query: 552 YNLEGDYYCACPD--DFGGKNCSVPREP-CPGGACRVIDGCGSDAGPGMPGTAASGVCGP 608
+Y C D GG S P GG G G+ GPG GT + G
Sbjct: 412 -----EYRRLCMDGLPMGGIPGSAGSRPGGTGGNGFAPSGNGNGYGPG--GTGFIPIPGG 464
Query: 609 HGRCVSQPGGNFSCICDSG----FTG-TYCHENIDDCL--GQPCRNGGTCIDEVDAFRCF 661
+G PG + + G TG T ++ ID C C N G CI V ++RC
Sbjct: 465 NG---FSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANLCLN-GRCIPTVSSYRCE 520
Query: 662 CPSGWE----GELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 717
C G++ G+ D ++C +PC + G C + +YC C G++ D
Sbjct: 521 CNMGYKQDANGDCIDV--DECTSNPC-TNGDCVNTPGSYYCKCHAGFQRTPTKQACIDID 577
Query: 718 -----AYTCSNGGTCYDSGDTFRCACPPGWK----GSTCAVAKNSSCLPNPCVNGGTCVG 768
C N G C ++ +F+C C G++ G C V + N C+N G C+
Sbjct: 578 ECIQNGVLCKN-GRCVNTDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLN-GMCIN 634
Query: 769 SGASFSCICRDGW----EGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA-GPD 823
SF CIC+ G+ GR CT P C NG C++ FRC+C PG A G D
Sbjct: 635 EDGSFKCICKPGFVLAPNGRYCTDVDECQTPGICMNGH-CINSEGSFRCDCPPGLAVGMD 693
Query: 824 CRINIDECQSSPCAYG---ATCVDEING----YRCSC--PPGRAGPRCQEVIGFGRSCWS 874
R+ +D S C G CV G C C P G CQ C +
Sbjct: 694 GRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQ-------PCPA 746
Query: 875 RGTPFPHG--SSWV------EDCNSCR-----CLDGRRDCSKVWCGWK-PCLLAGQPEAL 920
+ + HG SS V D N C C +G C + ++ C +P+A
Sbjct: 747 KNSAEFHGLCSSGVGITVDGRDINECALDPDICANG--ICENLRGSYRCNCNSGYEPDAS 804
Query: 921 SAQCPLGQRCL-----------EKAPG--QCLRPP----------CEAWGECGAEEPPST 957
C CL PG C PP CE EC + +
Sbjct: 805 GRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNG 864
Query: 958 PCLPRSGHLDNNCA 971
C G + C+
Sbjct: 865 ACRNNLGSFNCECS 878
Score = 159 bits (402), Expect = 2e-38
Identities = 187/694 (26%), Positives = 268/694 (38%), Gaps = 164/694 (23%)
Query: 244 VCKQGCNLLHGGCTVPG----ECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNW 299
+CK NL G +P C C+ G Y +G C++ +C
Sbjct: 497 ICKHHANLCLNGRCIPTVSSYRCECNMG-----------YKQDANGDCIDVDEC------ 539
Query: 300 GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNCEKAEHACTSNP 355
+ +PCTN G C+N P Y C C G+ + + C + +
Sbjct: 540 -------------TSNPCTN-GDCVNT-PGSYYCKCHAGFQRTPTKQACIDIDECIQNGV 584
Query: 356 CANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411
G C F+C C +G+ G C +D DEC + G C+++ F+CIC
Sbjct: 585 LCKNGRCVNTDGSFQCICNAGFELTTDGKNC-VDHDECTTTNMCLNGMCINEDGSFKCIC 643
Query: 412 PEQWV----GATCQLDANECEGKP-CLNAFSCKNLIGGYYCDCIPGWK-GINCHINVNDC 465
+V G C D +EC+ C+N C N G + CDC PG G++ + V+
Sbjct: 644 KPGFVLAPNGRYC-TDVDECQTPGICMNG-HCINSEGSFRCDCPPGLAVGMDGRVCVDTH 701
Query: 466 RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHS-GGLCEDL----ADGF 520
+GG K VC R F G + E C ++P + G C+ + F
Sbjct: 702 MRSTCYGGIKKG-------VCVRPFPGAVTKSEC--CCANPDYGFGEPCQPCPAKNSAEF 752
Query: 521 HCHCPQGFSGPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP- 577
H C G + D++ C +P C NG C NL G Y C NC+ EP
Sbjct: 753 HGLCSSGVGITVDGRDINECALDPDICANGI-CENLRGSYRC---------NCNSGYEPD 802
Query: 578 CPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF---TGTYCH 634
G C ID C + + +G C + P G++SC C G+ T T
Sbjct: 803 ASGRNCIDIDEC-----------LVNRLLCDNGLCRNTP-GSYSCTCPPGYVFRTETETC 850
Query: 635 ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 694
E+I++C PC N G C + + +F C C G +L T C+ +G C+ +
Sbjct: 851 EDINECESNPCVN-GACRNNLGSFNCECSPG--SKLSSTG-LICIDS---LKGTCWLNIQ 903
Query: 695 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRC----ACPPGW---KGSTC 747
D C+ G T S +C C+ G + S RC ACP G KG TC
Sbjct: 904 D--SRCEVNINGATLKS---EC----CATLGAAWGS-PCERCELDTACPRGLARIKGVTC 953
Query: 748 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG----WEGRTCTH----------NTNDC 793
P C N G CV S SF C C +G GR C + ++C
Sbjct: 954 EDVNECEVFPGVCPN-GRCVNSKGSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDEC 1012
Query: 794 -NPLP---CYNGGICVDGVNW-FRCECAP---------------GFA-------GPDCRI 826
+P+P + C G W CE P GFA G
Sbjct: 1013 IHPVPGKFRMDACCCAVGAAWGTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPFYK 1072
Query: 827 NIDECQSSP--CAYGATCVDEINGYRCSCPPGRA 858
+I+EC++ P C YG C + I ++C C G A
Sbjct: 1073 DINECKAFPGMCTYG-KCRNTIGSFKCRCNSGFA 1105
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 234 bits (596), Expect = 5e-61
Identities = 248/881 (28%), Positives = 321/881 (36%), Gaps = 224/881 (25%)
Query: 161 LLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCN-----KFCRPRN 215
LL + A +N ED H+ + ++ D+ YY++ + K R R
Sbjct: 15 LLCHWIGTASPLNLEDPNVCSHWESYSVTVQESYPHPFDQIYYTSCTDILNWFKCTRHRV 74
Query: 216 DF-----FGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQG 270
+ G T + ++ C + E C C +HG C P C+C GW G
Sbjct: 75 SYRTAYRHGEKTMYRRKSQCCPGFYESGEMCVPHCADKC--VHGRCIAPNTCQCEPGWGG 132
Query: 271 RFCD----------ECVPYPGCVHGSCVEP--WQCNCETNWGGLLCDKDL------NYCG 312
C C C +G+ P C+C + G C+ N C
Sbjct: 133 TNCSSACDGDHWGPHCTSRCQCKNGALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCH 192
Query: 313 SHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE----------KAEHACTSNPCANGGSC 362
C NG TC + + C CP GY+G CE + E C PC NGG C
Sbjct: 193 QRCQCQNGATCDHVTGE---CRCPPGYTGAFCEDLCPPGKHGPQCEQRC---PCQNGGVC 246
Query: 363 HEVPSGFECHCPSGWSGPTCALDIDE------CASN-PCAAGGTCVDQVDGFECICPEQW 415
H V EC CPSGW G C E C+ C GGTC D G +C C +
Sbjct: 247 HHVTG--ECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTC-DAATG-QCHCSPGY 302
Query: 416 VGATCQ----------LDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDC 465
G CQ L A C+ C+N C ++ G C C G+ G C +
Sbjct: 303 TGERCQDECPVGTYGVLCAETCQ---CVNGGKCYHVSGA--CLCEAGFAGERCEARL--- 354
Query: 466 RGQCQHGGTCKDLVNGYQC--VCPRGFGGRH-CELERDECASSPCHSGGLCEDLADGFHC 522
C + + G +C CP H C ECA P SG C +
Sbjct: 355 ---------CPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNET------ 399
Query: 523 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 582
C GF G C+ +C C+NGA C ++ G C C F G +CS PCP G
Sbjct: 400 -CSPGFYGEACQ---QICS---CQNGADCDSVTGK--CTCAPGFKGIDCST---PCPLGT 447
Query: 583 ----CRVIDGCGSDAGPGMPGTAASGVCGP-HGRCVSQPGG---NFSCICDSGFTGTYCH 634
C GC +DA VC P G C + G + S C SG G C+
Sbjct: 448 YGINCSSRCGCKNDA-----------VCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCN 496
Query: 635 ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 694
L C NGG C + +D C C GW GE C+ LP
Sbjct: 497 ------LTCQCLNGGAC-NTLDG-TCTCAPGWRGEKCE------LP-------------- 528
Query: 695 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKG----STCAVA 750
C DG G C R CD CS+ C+ + T C C PGW G S CA
Sbjct: 529 -----CQDGTYGLNCAER---CD---CSHADGCHPT--TGHCRCLPGWSGVHCDSVCAEG 575
Query: 751 K-NSSC-LPNPCVNGGTCVGSGASFSCICRDGWEGRTCT---------HNTNDCNPLPCY 799
+ +C LP C NG +C S C C G+ G TC H + P +
Sbjct: 576 RWGPNCSLPCYCKNGASC--SPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVH 633
Query: 800 NGGIC--VDGVNWFRCECAPGFAGPDCRINIDECQS----SPCAYGATCVDEING----- 848
+ G C + G+ C+C PGF G C + C S CA TC + NG
Sbjct: 634 SSGPCHHITGL----CDCLPGFTGALCN---EVCPSGRFGKNCAGICTCTN--NGTCNPI 684
Query: 849 -YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS-----CRCLDGRRDCS 902
C C PG G C + P G + + CN C DG C+
Sbjct: 685 DRSCQCYPGWIGSDCSQPC----------PPAHWGPNCIHTCNCHNGAFCSAYDGECKCT 734
Query: 903 KVWCGWK-----PCLLAGQPEALSAQCPLGQRCLEKAPGQC 938
W G P G+ AL QC G C + GQC
Sbjct: 735 PGWTGLYCTQRCPLGFYGKDCALICQCQNGADC-DHISGQC 774
Score = 192 bits (487), Expect = 2e-48
Identities = 196/723 (27%), Positives = 262/723 (36%), Gaps = 167/723 (23%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV--------CKQGC 249
CD +++ C C+ +N G G C G+ G C++ C Q C
Sbjct: 139 CDGDHWGPHCTSRCQCKN---GALCNPITGACHCAAGFRGWRCEDRCEQGTYGNDCHQRC 195
Query: 250 NLLHGGCT--VPGECRCSYGWQGRFCDECVPYPG-----------CVHGSCVE--PWQCN 294
+G V GECRC G+ G FC++ P PG C +G +C+
Sbjct: 196 QCQNGATCDHVTGECRCPPGYTGAFCEDLCP-PGKHGPQCEQRCPCQNGGVCHHVTGECS 254
Query: 295 CETNWGGLLCDKDL------NYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAE 348
C + W G +C + C C NGGTC A +C C GY+G C+
Sbjct: 255 CPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATG---QCHCSPGYTGERCQDEC 311
Query: 349 HACTSN-------PCANGGSCHEVPSGFECHCPSGWSGPTCALDID-------ECASN-P 393
T C NGG C+ V C C +G++G C + +C P
Sbjct: 312 PVGTYGVLCAETCQCVNGGKCYHVSGA--CLCEAGFAGERCEARLCPEGLYGIKCDKRCP 369
Query: 394 CAAGGTCVDQVDGFECICPEQWVGATCQLDANE-CEGKPCLNAFSCKNLIGGYYCD---- 448
C T EC C W G C + G+ C SC+N G CD
Sbjct: 370 CHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICSCQN---GADCDSVTG 426
Query: 449 ---CIPGWKGINCH---------INVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
C PG+KGI+C IN + G C++ C V+G C C G+ G C
Sbjct: 427 KCTCAPGFKGIDCSTPCPLGTYGINCSSRCG-CKNDAVCSP-VDG-SCTCKAGWHGVDCS 483
Query: 497 LERDECASSP----------CHSGGLCEDLADGFHCHCPQGFSGPLCEVD-------VDL 539
+ C S C +GG C L DG C C G+ G CE+ ++
Sbjct: 484 IR---CPSGTWGFGCNLTCQCLNGGACNTL-DGT-CTCAPGWRGEKCELPCQDGTYGLNC 538
Query: 540 CEPSPCRNGARCYNLEGDYYC-----------ACPDDFGGKNCSVPREPCPGGACRVIDG 588
E C + C+ G C C + G NCS+P G +C DG
Sbjct: 539 AERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDG 598
Query: 589 CGSDAGPGMPGTAASGVCGP--HGRCVSQ----------PGGNFSCICDS--GFTGTYCH 634
+ PG GT +C P +G SQ P + + +CD GFTG C+
Sbjct: 599 I-CECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCN 657
Query: 635 ENID------DCLGQ-PCRNGGTCIDEVDAFRCFCPSGWEGELCDT-------NPNDCLP 680
E +C G C N GTC + +D C C GW G C PN
Sbjct: 658 EVCPSGRFGKNCAGICTCTNNGTC-NPIDR-SCQCYPGWIGSDCSQPCPPAHWGPNCIHT 715
Query: 681 DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSR----------EFQCDAYTCSNGGTC-YD 729
CH+ C D C C GW G C R C C NG C +
Sbjct: 716 CNCHNGAFCS--AYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQ---CQNGADCDHI 770
Query: 730 SGDTFRCACPPGWKGSTCAVAKNSSCLPN------PCVNGGTCVGSGASFSCICRDGWEG 783
SG +C C G+ G C S C+N TC + +C C GW+G
Sbjct: 771 SG---QCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTC--DHITGTCYCSPGWKG 825
Query: 784 RTC 786
C
Sbjct: 826 ARC 828
Score = 185 bits (469), Expect = 3e-46
Identities = 191/682 (28%), Positives = 242/682 (35%), Gaps = 165/682 (24%)
Query: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQ 247
RC++ Y C++ C+ +N TCD G C G+ G C++ C+Q
Sbjct: 181 RCEQGTYGNDCHQRCQCQNGA----TCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQ 236
Query: 248 GCNLLHGGCT--VPGECRCSYGW----------QGRFCDECVPYPGCVHGSCVEP--WQC 293
C +GG V GEC C GW +GRF C C +G + QC
Sbjct: 237 RCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATGQC 296
Query: 294 NCETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE-- 345
+C + G C + C C NGG C + C C G++G CE
Sbjct: 297 HCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSG---ACLCEAGFAGERCEAR 353
Query: 346 ---------KAEHACTSNPC--ANGGSCHEVPSGFECHCPSGWSG----PTCALDI--DE 388
K + C PC N SCH P EC C GWSG TC+ +
Sbjct: 354 LCPEGLYGIKCDKRC---PCHLENTHSCH--PMSGECACKPGWSGLYCNETCSPGFYGEA 408
Query: 389 CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDAN------ECEGK-PCLNAFSCKNL 441
C G D V G +C C + G C C + C N C +
Sbjct: 409 CQQICSCQNGADCDSVTG-KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPV 467
Query: 442 IGGYYCDCIPGWKGINCHINVN--------DCRGQCQHGGTCKDLVNGYQCVCPRGFGGR 493
G C C GW G++C I + QC +GG C L C C G+ G
Sbjct: 468 DGS--CTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNTLDG--TCTCAPGWRGE 523
Query: 494 HCEL------------ERDECASSP-CH-SGGLCEDLA--DGFHCH--CPQGFSGPLCEV 535
CEL ER +C+ + CH + G C L G HC C +G GP C +
Sbjct: 524 KCELPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGVHCDSVCAEGRWGPNCSL 583
Query: 536 DVDLCEPSPCRNGARCYNLEGDYYCA-----------CPDDFGGKNCSVPREPC--PGGA 582
P C+NGA C +G CA C F G CS C G
Sbjct: 584 ------PCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGP 637
Query: 583 CRVIDGCGSDAGPGMPGTAASGVCGPHGR--------CVSQPGGNF-----SCICDSGFT 629
C I G D PG G + VC P GR C G SC C G+
Sbjct: 638 CHHITGL-CDCLPGFTGALCNEVC-PSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWI 695
Query: 630 GTYCHENIDDCLGQP-------CRNGGTCIDEVDAFRCFCPSGWEGELCDTN------PN 676
G+ C + P C NG C D C C GW G C
Sbjct: 696 GSDCSQPCPPAHWGPNCIHTCNCHNGAFC-SAYDG-ECKCTPGWTGLYCTQRCPLGFYGK 753
Query: 677 DC-LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT----------CSNGG 725
DC L C + C + C C G+ G+ C E +C + T C N
Sbjct: 754 DCALICQCQNGADCDHISGQ--CTCRTGFMGRHC---EQKCPSGTYGYGCRQICDCLNNS 808
Query: 726 TCYDSGDTFRCACPPGWKGSTC 747
TC T C C PGWKG+ C
Sbjct: 809 TCDHITGT--CYCSPGWKGARC 828
Score = 158 bits (400), Expect = 3e-38
Identities = 154/587 (26%), Positives = 217/587 (36%), Gaps = 137/587 (23%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKE--------AVCKQG 248
C E + C++ C+ N TCD G C G+ G+ C++ +C +
Sbjct: 268 CPEGRFGKNCSQECQCHNGG----TCDAATGQCHCSPGYTGERCQDECPVGTYGVLCAET 323
Query: 249 CNLLHGGCT--VPGECRCSYGWQGRFCD---------------ECVPYPGCVHGSCVEPW 291
C ++GG V G C C G+ G C+ C + H
Sbjct: 324 CQCVNGGKCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCDKRCPCHLENTHSCHPMSG 383
Query: 292 QCNCETNWGGLLCDKDLN------YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCE 345
+C C+ W GL C++ + C C NG C + +CTC G+ G +C
Sbjct: 384 ECACKPGWSGLYCNETCSPGFYGEACQQICSCQNGADCDSVTG---KCTCAPGFKGIDCS 440
Query: 346 KAEHA------CTSN-PCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNP----- 393
C+S C N C V C C +GW G C++ C S
Sbjct: 441 TPCPLGTYGINCSSRCGCKNDAVCSPVDGS--CTCKAGWHGVDCSI---RCPSGTWGFGC 495
Query: 394 -----CAAGGTCVDQVDGFECICPEQWVGATCQLDANE-CEGKPCLNAFSCKNLIGGY-- 445
C GG C + +DG C C W G C+L + G C C + G +
Sbjct: 496 NLTCQCLNGGAC-NTLDG-TCTCAPGWRGEKCELPCQDGTYGLNCAERCDCSHADGCHPT 553
Query: 446 --YCDCIPGWKGINCHINVNDCRG--------QCQHGGTCK------DLVNGY-----QC 484
+C C+PGW G++C + R C++G +C + G+ Q
Sbjct: 554 TGHCRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQR 613
Query: 485 VCPRGFGGRHCELERDEC--ASSPCHS-GGLCEDLAD--GFHCH--CPQGFSGPLCEVDV 537
+C GF G C +C +S PCH GLC+ L G C+ CP G G C
Sbjct: 614 ICSPGFYGHRCSQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNC---A 670
Query: 538 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP------------CPGGA-CR 584
+C C N C + D C C + G +CS P P C GA C
Sbjct: 671 GICT---CTNNGTCNPI--DRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCS 725
Query: 585 VIDGCGSDAGPGMPGTAASGVC--GPHGR-----CVSQPGGNFS-----CICDSGFTGTY 632
DG PG G + C G +G+ C Q G + C C +GF G +
Sbjct: 726 AYDG-ECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRH 784
Query: 633 CHENIDD-CLGQPCR------NGGTCIDEVDAFRCFCPSGWEGELCD 672
C + G CR N TC D + C+C GW+G CD
Sbjct: 785 CEQKCPSGTYGYGCRQICDCLNNSTC-DHITG-TCYCSPGWKGARCD 829
Score = 60.5 bits (145), Expect = 1e-08
Identities = 48/188 (25%), Positives = 71/188 (37%), Gaps = 41/188 (21%)
Query: 198 CDENYYSATCNKFC---RPRNDFFGHYTCDQYG-------NKACMDGWMGKECKEAV--- 244
C + A CN+ C R + G TC G + C GW+G +C +
Sbjct: 647 CLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPGWIGSDCSQPCPPA 706
Query: 245 -----CKQGCNLLHGG-CTV-PGECRCSYGWQGRFCDE----------CVPYPGCVHGSC 287
C CN +G C+ GEC+C+ GW G +C + C C +G+
Sbjct: 707 HWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFYGKDCALICQCQNGAD 766
Query: 288 VE--PWQCNCETNWGGLLCDKDLNY------CGSHHPCTNGGTCINAEPDQYRCTCPDGY 339
+ QC C T + G C++ C C N TC + C C G+
Sbjct: 767 CDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQICDCLNNSTCDHITGT---CYCSPGW 823
Query: 340 SGRNCEKA 347
G C++A
Sbjct: 824 KGARCDQA 831
Score = 48.1 bits (113), Expect = 5e-05
Identities = 27/90 (30%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEAV--------CKQ 247
RC +Y C C+ +N CD G C G+MG+ C++ C+Q
Sbjct: 745 RCPLGFYGKDCALICQCQNGA----DCDHISGQCTCRTGFMGRHCEQKCPSGTYGYGCRQ 800
Query: 248 GCNLLHGGCT--VPGECRCSYGWQGRFCDE 275
C+ L+ + G C CS GW+G CD+
Sbjct: 801 ICDCLNNSTCDHITGTCYCSPGWKGARCDQ 830
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 229 bits (583), Expect = 2e-59
Identities = 112/308 (36%), Positives = 158/308 (51%), Gaps = 16/308 (5%)
Query: 275 ECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQ---- 330
EC C + C CE + G C+ + + C PC N +CI+A Q
Sbjct: 318 ECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDAC-QRKPCQNNASCIDANEKQDGSN 375
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
+ C C GY+G C+ C +PC NG +C SGF C CP G+ G C +D CA
Sbjct: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCA 435
Query: 391 SNPCAAGGTCVDQVDG--FECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCD 448
S+PC GTC VDG F C C + G TC + C PC + +C+++ Y C
Sbjct: 436 SSPCQNNGTCY--VDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKCL 492
Query: 449 CIPGWKGINCHINVNDC-RGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPC 507
C PG+ G+ C N+C C + TC+DLVNGY+CVC + G HCEL +D CA+ C
Sbjct: 493 CDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSC 552
Query: 508 HSGGLCEDLADGFH--CHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
+G C+ +DG + C C GF+G C++D++ C+ +PC +G C + Y C CP
Sbjct: 553 LNGATCD--SDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHG 610
Query: 566 FGGKNCSV 573
+ G NC +
Sbjct: 611 WVGANCEI 618
Score = 223 bits (568), Expect = 9e-58
Identities = 117/343 (34%), Positives = 157/343 (45%), Gaps = 41/343 (11%)
Query: 535 VDVDLCEPSP-------CRNGARCYNL--EGDYYCACPDDFGGKNC----SVPREPCPGG 581
V V C P C +C E + C C + + G C + R+PC
Sbjct: 302 VKVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYDACQRKPCQNN 361
Query: 582 ACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL 641
A + DA Q G NF+C+C G+TG C ID C+
Sbjct: 362 ASCI------DANE------------------KQDGSNFTCVCLPGYTGELCQSKIDYCI 397
Query: 642 GQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACD 701
PCRNG TCI + F C CP G+ G C+ + C PC + G CY F C C
Sbjct: 398 LDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCS 457
Query: 702 DGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCV 761
G+ G TC C C++ GTC G +++C C PG+ G C N CL PC+
Sbjct: 458 PGFTGPTCAQLIDFCALSPCAH-GTCRSVGTSYKCLCDPGYHGLYCEEEYN-ECLSAPCL 515
Query: 762 NGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGIC-VDGVNWFRCECAPGFA 820
N TC + C+C ++G C + C + C NG C DG+N C CAPGF
Sbjct: 516 NAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNG-TCICAPGFT 574
Query: 821 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ 863
G +C I+I+EC S+PC +G +C+D+ NGY C CP G G C+
Sbjct: 575 GEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 199 bits (507), Expect = 1e-50
Identities = 111/371 (29%), Positives = 158/371 (42%), Gaps = 60/371 (16%)
Query: 381 TCALDIDECASNPCAAGGTCVDQVDG--FECICPEQWVGATCQLDANECEGKPCLNAFSC 438
TC C+ G C + F C C EQ+VG C+ + + C+ KPC N SC
Sbjct: 306 TCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE-EYDACQRKPCQNNASC 364
Query: 439 KNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELE 498
I+ N+ K + + CVC G+ G C+ +
Sbjct: 365 ---------------------IDANE-----------KQDGSNFTCVCLPGYTGELCQSK 392
Query: 499 RDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDY 558
D C PC +G C GF C CP+G+ G CE VD C SPC+N CY +
Sbjct: 393 IDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
Query: 559 YCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGG 618
C C F G C+ ++ID C A C HG C S G
Sbjct: 453 TCNCSPGFTGPTCA-----------QLIDFC------------ALSPCA-HGTCRS-VGT 487
Query: 619 NFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDC 678
++ C+CD G+ G YC E ++CL PC N TC D V+ + C C + ++G C+ + C
Sbjct: 488 SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPC 547
Query: 679 LPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCAC 738
C + C + C C G+ G+ C +CD+ C +GG+C D + + C C
Sbjct: 548 ANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHC 607
Query: 739 PPGWKGSTCAV 749
P GW G+ C +
Sbjct: 608 PHGWVGANCEI 618
Score = 192 bits (489), Expect = 1e-48
Identities = 96/314 (30%), Positives = 146/314 (46%), Gaps = 32/314 (10%)
Query: 520 FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE-----GDYYCACPDDFGGKNCSVP 574
F C C + + G CE + D C+ PC+N A C + ++ C C + G+ C
Sbjct: 334 FSCTCEEQYVGTFCE-EYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSK 392
Query: 575 REPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCH 634
+ C ++D C + A C+S G F+C C G+ G+ C
Sbjct: 393 IDYC------ILDPCRNGA-----------------TCISSLSG-FTCQCPEGYFGSACE 428
Query: 635 ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVN 694
E +D C PC+N GTC + F C C G+ G C + C PC + G C +
Sbjct: 429 EKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPC-AHGTCRSVGT 487
Query: 695 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS 754
+ C CD G+ G C +C + C N TC D + + C C +KG+ C + K+
Sbjct: 488 SYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDP- 546
Query: 755 CLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCE 814
C C+NG TC G + +CIC G+ G C + N+C+ PC++GG C+D N + C
Sbjct: 547 CANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCH 606
Query: 815 CAPGFAGPDCRINI 828
C G+ G +C I++
Sbjct: 607 CPHGWVGANCEIHL 620
Score = 152 bits (385), Expect = 1e-36
Identities = 92/309 (29%), Positives = 138/309 (44%), Gaps = 39/309 (12%)
Query: 198 CDENYYSATCNKF--CRPRNDFFGHYTCDQYGNK--------ACMDGWMGKECKEAV--- 244
C+E Y C ++ C+ R + +C K C+ G+ G+ C+ +
Sbjct: 338 CEEQYVGTFCEEYDACQ-RKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYC 396
Query: 245 ----CKQGCNLLHG--GCTVPGECRCSYGWQGRFCDE----CVPYPGCVHGSCVEP---W 291
C+ G + G T C+C G+ G C+E C P +G+C +
Sbjct: 397 ILDPCRNGATCISSLSGFT----CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
Query: 292 QCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHAC 351
CNC + G C + +++C PC +G TC + Y+C C GY G CE+ + C
Sbjct: 453 TCNCSPGFTGPTCAQLIDFCALS-PCAHG-TC-RSVGTSYKCLCDPGYHGLYCEEEYNEC 509
Query: 352 TSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECIC 411
S PC N +C ++ +G+EC C + + G C L D CA+ C G TC CIC
Sbjct: 510 LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCIC 569
Query: 412 PEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQH 471
+ G C +D NEC+ PC + SC + GY C C GW G NC I++ Q +
Sbjct: 570 APGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCEIHL-----QWKS 624
Query: 472 GGTCKDLVN 480
G + L N
Sbjct: 625 GHMAESLTN 633
Score = 123 bits (309), Expect = 9e-28
Identities = 94/324 (29%), Positives = 132/324 (40%), Gaps = 46/324 (14%)
Query: 705 KGKTCHSREFQCDAYTCSNGGTCYD--SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVN 762
K TC E + CS G C S TF C C + G+ C + +C PC N
Sbjct: 303 KVSTCVPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCE--EYDACQRKPCQN 360
Query: 763 GGTCVGS-----GASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAP 817
+C+ + G++F+C+C G+ G C + C PC NG C+ ++ F C+C
Sbjct: 361 NASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPE 420
Query: 818 GFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGF-------GR 870
G+ G C +D C SSPC TC + + C+C PG GP C ++I F
Sbjct: 421 GYFGSACEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG 480
Query: 871 SCWSRGT-------PFPHGSSWVEDCNSC---RCLDGRRDCSKVWCGWKPCLLAG----- 915
+C S GT P HG E+ N C CL+ C + G++ LA
Sbjct: 481 TCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNA-ATCRDLVNGYECVCLAEYKGTH 539
Query: 916 ----QPEALSAQCPLGQRC-LEKAPGQCLRPPCEAWGECGAE--EPPSTPCLPRSGHLDN 968
+ + C G C + G C+ P EC + E S PC H
Sbjct: 540 CELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECDSNPC-----HHGG 594
Query: 969 NCARLTLHFNRDHVPQGTTVGAIC 992
+C +N H P G VGA C
Sbjct: 595 SCLDQPNGYN-CHCPHG-WVGANC 616
Score = 67.4 bits (163), Expect = 8e-11
Identities = 34/86 (39%), Positives = 42/86 (48%), Gaps = 15/86 (17%)
Query: 351 CTSNPCANGGSC---------HEVPSG---FECHCPSGWSGPTCALDIDECASNPCAAG- 397
C + PC NGG C H P+G + C CP+G SG C L D CASNPC G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 398 --GTCVDQVDGFECICPEQWVGATCQ 421
+ DG+ CIC E + G C+
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 66.6 bits (161), Expect = 1e-10
Identities = 32/86 (37%), Positives = 41/86 (47%), Gaps = 16/86 (18%)
Query: 465 CRGQ-CQHGGTCKDLVN------------GYQCVCPRGFGGRHCELERDECASSPCHSGG 511
C Q C++GG C GY C CP G G +C+L D CAS+PCH G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 512 L---CEDLADGFHCHCPQGFSGPLCE 534
+DG+ C C +G+ GP CE
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 65.9 bits (159), Expect = 2e-10
Identities = 33/81 (40%), Positives = 38/81 (46%), Gaps = 14/81 (17%)
Query: 316 PCTNGGTCINA-EPDQ----------YRCTCPDGYSGRNCEKAEHACTSNPCANG---GS 361
PC NGG C + EPD Y CTCP G SG NC+ C SNPC +G S
Sbjct: 52 PCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSS 111
Query: 362 CHEVPSGFECHCPSGWSGPTC 382
G+ C C G+ GP C
Sbjct: 112 SSSSSDGYLCICNEGYEGPNC 132
Score = 59.3 bits (142), Expect = 2e-08
Identities = 27/89 (30%), Positives = 41/89 (46%), Gaps = 15/89 (16%)
Query: 793 CNPLPCYNGGICVD------------GVNWFRCECAPGFAGPDCRINIDECQSSPCAYG- 839
C PC NGG+C G + C C G +G +C++ D C S+PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 840 --ATCVDEINGYRCSCPPGRAGPRCQEVI 866
++ +GY C C G GP C++ +
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
Score = 58.5 bits (140), Expect = 4e-08
Identities = 29/96 (30%), Positives = 44/96 (45%), Gaps = 17/96 (17%)
Query: 502 CASSPCHSGGLCEDLAD------------GFHCHCPQGFSGPLCEVDVDLCEPSPCRNG- 548
CA+ PC +GG+C + G+ C CP G SG C++ D C +PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 549 --ARCYNLEGDYYCACPDDFGGKNC--SVPREPCPG 580
+ + Y C C + + G NC ++P P G
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQALPSLPATG 143
Score = 57.0 bits (136), Expect = 1e-07
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 15/85 (17%)
Query: 389 CASNPCAAGGTCVDQVD------------GFECICPEQWVGATCQLDANECEGKPCLN-- 434
CA+ PC GG C + + G+ C CP GA CQL A+ C PC +
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 435 -AFSCKNLIGGYYCDCIPGWKGINC 458
+ S + GY C C G++G NC
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 55.5 bits (132), Expect = 3e-07
Identities = 26/86 (30%), Positives = 37/86 (43%), Gaps = 17/86 (19%)
Query: 640 CLGQPCRNGGTCIDEVD------------AFRCFCPSGWEGELCDTNPNDCLPDPCHSRG 687
C QPCRNGG C + + C CP+G G C + C +PCH G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH-HG 106
Query: 688 RCYDLVND----FYCACDDGWKGKTC 709
C + + C C++G++G C
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 52.4 bits (124), Expect = 3e-06
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 16/86 (18%)
Query: 716 CDAYTCSNGGTCYDSGDT------------FRCACPPGWKGSTCAVAKNSSCLPNPCVNG 763
C A C NGG C + + C CP G G+ C + + C NPC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVAD-PCASNPCHHG 106
Query: 764 GTCVGSGAS---FSCICRDGWEGRTC 786
S +S + CIC +G+EG C
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNC 132
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/89 (29%), Positives = 37/89 (41%), Gaps = 14/89 (15%)
Query: 598 PGTAASGVCGPHGRCVSQPGGN-----------FSCICDSGFTGTYCHENIDDCLGQPCR 646
PG A+ C G C S+P + +SC C +G +G C D C PC
Sbjct: 45 PGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH 104
Query: 647 NG---GTCIDEVDAFRCFCPSGWEGELCD 672
+G + D + C C G+EG C+
Sbjct: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 48.5 bits (114), Expect = 4e-05
Identities = 28/111 (25%), Positives = 36/111 (32%), Gaps = 39/111 (35%)
Query: 540 CEPSPCRNGARCYNL------------EGDYYCACPDDFGGKNCSVPREPCPGGACRVID 587
C PCRNG C + E Y C CP G NC + +PC C
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCH--- 104
Query: 588 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGN---FSCICDSGFTGTYCHE 635
HG C S + + CIC+ G+ G C +
Sbjct: 105 ---------------------HGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/95 (31%), Positives = 41/95 (43%), Gaps = 6/95 (6%)
Query: 257 TVPGECRCSYGWQGRFCDECVPYPGCVHGSCV-EP-WQCNCETNWGGLLCDKDLNYCGSH 314
+ PG C G C P P H + EP + C C G C + C S+
Sbjct: 43 SAPGPCAAQPCRNGGVCTSR-PEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
Query: 315 HPCTNGG--TCINAEPDQYRCTCPDGYSGRNCEKA 347
PC +G + ++ D Y C C +GY G NCE+A
Sbjct: 102 -PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQA 135
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/85 (27%), Positives = 31/85 (36%), Gaps = 15/85 (17%)
Query: 755 CLPNPCVNGGTCVG------------SGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGG 802
C PC NGG C +SC C G G C + C PC++G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 803 I---CVDGVNWFRCECAPGFAGPDC 824
+ + C C G+ GP+C
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNC 132
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 227 bits (578), Expect = 6e-59
Identities = 229/854 (26%), Positives = 310/854 (36%), Gaps = 210/854 (24%)
Query: 172 INPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCN-----KFCRPRNDFFGHY----- 221
+NPED H+ + ++ D+ YY+ + K R R + Y
Sbjct: 20 LNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLR 79
Query: 222 TCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCD------- 274
T + ++ C + + +C + C +HG C P C C GW G C
Sbjct: 80 TMYRRRSQCCPGYYESGDFCIPLCTEEC--VHGRCVSPDTCHCEPGWGGPDCSSGCDSDH 137
Query: 275 ---ECVPYPGCVHGSCVEP--WQCNCETNWGGLLCDKDLNYCGSHH-------PCTNGGT 322
C C +G+ P C C + G C+ +L G+H C +G +
Sbjct: 138 WGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCE-ELCAPGTHGKGCQLPCQCRHGAS 196
Query: 323 CINAEPDQYRCTCPDGYSGRNCEK-------AEHACTSNPCANGGSCHEVPSGFECHCPS 375
C +P C C GY+G CE+ H PC NGG+CH + EC CP
Sbjct: 197 C---DPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITG--ECACPP 251
Query: 376 GWSGPTCALDI------DECASN-PCAAGGTCVDQVDGFECICPEQWVGATCQLD----- 423
GW+G CA C+ + PC GG C D V G +C C ++G CQ +
Sbjct: 252 GWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQC-DHVTG-QCHCTAGYMGDRCQEECPFGS 309
Query: 424 -----ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCH------------------- 459
+ C+ C N C G C+C PG+KG C
Sbjct: 310 FGFQCSQHCD---CHNGGQCSPTTGA--CECEPGYKGPRCQERLCPEGLHGPGCTLPCPC 364
Query: 460 -----INVNDCRGQCQHGGTCKDLVNGYQC--VCPRGFGGRHCELERDECASSPCHSGGL 512
I+ + G C TC+ +G+ C CP G+ G C+L C +G
Sbjct: 365 DADNTISCHPVTGAC----TCQPGWSGHHCNESCPVGYYGDGCQL------PCTCQNGAD 414
Query: 513 CEDLADGFHCHCPQGFSGPLCEVDVDLCEPSP-------CRNGARCYNLEGDYYCACPDD 565
C + G C C GF G +C V P C NG C ++G C C +
Sbjct: 415 CHSITGG--CTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGS--CTCKEG 470
Query: 566 FGGKNCSVP----------REPCP---GGACRVIDG-CGSDAG--------PGMPGTAAS 603
+ G +C++P E C G AC IDG C G P GT
Sbjct: 471 WQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGL 530
Query: 604 GVCGPHGRCVSQPGGN---FSCICDSGFTGTYCHENIDDCLGQP-------CRNGGTCID 653
C H C G + C C +G+TG C P C NGG+C
Sbjct: 531 N-CSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSP 589
Query: 654 EVDAFRCFCPSGWEGELCDTNPNDCLP--------DPC----HSRGRCYDLVNDFYCACD 701
E + C C G+ G LC C P PC HS C+ + C C
Sbjct: 590 EDGS--CECAPGFRGPLCQ---RICPPGFYGHGCAQPCPLCVHSSRPCHHISG--ICECL 642
Query: 702 DGWKGKTCHS-------REFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSS 754
G+ G C+ + +C+N GTC S C C PGW G C+ A
Sbjct: 643 PGFSGALCNQVCAGGYFGQDCAQLCSCANNGTC--SPIDGSCQCFPGWIGKDCSQA---- 696
Query: 755 CLPN----------PCVNGGTCVGSGASFSCICRDGWEGRTCTHNT------NDCNPL-P 797
C P C NG +C S +C C GW G CT DC +
Sbjct: 697 CPPGFWGPACFHACSCHNGASC--SAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQ 754
Query: 798 CYNGGICVDGVNWFRCECAPGFAGPDCRINIDE------CQS-SPCAYGATCVDEINGYR 850
C NG C D ++ +C C GF G C CQ C +TC D + G
Sbjct: 755 CQNGASC-DHISG-KCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTC-DHVTG-T 810
Query: 851 CSCPPGRAGPRCQE 864
C C PG G RC +
Sbjct: 811 CYCSPGFKGIRCDQ 824
Score = 63.5 bits (153), Expect = 1e-09
Identities = 47/179 (26%), Positives = 70/179 (39%), Gaps = 36/179 (20%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQY-GNKACMDGWMGKECKEA--------VCKQG 248
C Y+ C + C N+ TC G+ C GW+GK+C +A C
Sbjct: 654 CAGGYFGQDCAQLCSCANNG----TCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHA 709
Query: 249 CNLLHGG-CTVP-GECRCSYGWQGRFCDECVPYP----------GCVHGSCVE--PWQCN 294
C+ +G C+ G C C+ GW G FC + P C +G+ + +C
Sbjct: 710 CSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCT 769
Query: 295 CETNWGGLLCDK-----DLNY-CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKA 347
C T + G C++ Y C C N TC + C C G+ G C++A
Sbjct: 770 CRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGT---CYCSPGFKGIRCDQA 825
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 225 bits (574), Expect = 2e-58
Identities = 97/223 (43%), Positives = 132/223 (59%), Gaps = 2/223 (0%)
Query: 315 HPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCP 374
+PC N GTC Y C CP GY+G CE C+ PC N G C ++ F C CP
Sbjct: 1200 NPCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECP 1258
Query: 375 SGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLN 434
SG++G C +I+EC+S+PC G CVD V G+ C C + +VG C+ + NEC+ PCLN
Sbjct: 1259 SGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLN 1318
Query: 435 AFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGR 493
C++ +GG+ C C PG+ G C NV++C Q C++G TCKD N ++C+C GF G
Sbjct: 1319 NAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGS 1378
Query: 494 HCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVD 536
HCEL +EC S+PC + C D + + C C GFSG CE +
Sbjct: 1379 HCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 224 bits (571), Expect = 4e-58
Identities = 94/224 (41%), Positives = 126/224 (56%), Gaps = 1/224 (0%)
Query: 349 HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFE 408
H C NPC N G+C ++ G+ C CP G++G C DIDEC+ PC G C D V F
Sbjct: 1195 HECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFI 1254
Query: 409 CICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ 468
C CP + G C+ + NEC PCLN C + + GY C C+ G+ G++C VN+C+
Sbjct: 1255 CECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSN 1314
Query: 469 -CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQG 527
C + C+D V G+ C CP GF G C DEC S PC +G C+D A+ F C C G
Sbjct: 1315 PCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAG 1374
Query: 528 FSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
F+G CE++++ C+ +PCRN A C + Y C C F GK C
Sbjct: 1375 FTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRC 1418
Score = 223 bits (569), Expect = 7e-58
Identities = 144/441 (32%), Positives = 188/441 (42%), Gaps = 69/441 (15%)
Query: 478 LVNGYQCV-CPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCH-CPQG-FSGPLCE 534
++ G CV CP G + LE C S C G +D C CP G ++ +
Sbjct: 993 VLRGRMCVNCPLG---TYYNLEHFTCES--CRIGSY-QDEEGQLECKLCPSGMYTEYIHS 1046
Query: 535 VDVDLCEPSPCRNGARCYNLEGDYYC-ACP-----DDFGGKNCSVPREPCPGGACRV--- 585
++ C+ + C+ G Y+ G C +CP FG ++C CP V
Sbjct: 1047 RNISDCK-AQCKQGT--YSYSGLETCESCPLGTYQPKFGSRSCL----SCPENTSTVKRG 1099
Query: 586 ---IDGCGSDAGPGMPGTAASGVCGPHGRCVSQP--GGNFSCICD--------------- 625
I CG G + C P R QP G F C
Sbjct: 1100 AVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFCLACPFYGTTPFAGSRSITE 1159
Query: 626 -SGFTGTYC------------------HEN----IDDCLGQPCRNGGTCIDEVDAFRCFC 662
S F+ T+ HE +C PC N GTC + C C
Sbjct: 1160 CSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFNPCHNSGTCQQLGRGYVCLC 1219
Query: 663 PSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCS 722
P G+ G C+T+ ++C P PC + G C DLV +F C C G+ G+ C +C + C
Sbjct: 1220 PLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCL 1279
Query: 723 NGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWE 782
N G C D +RC C G+ G C N C NPC+N C F C C G+
Sbjct: 1280 NKGICVDGVAGYRCTCVKGFVGLHCETEVNE-CQSNPCLNNAVCEDQVGGFLCKCPPGFL 1338
Query: 783 GRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATC 842
G C N ++C PC NG C DG N FRC CA GF G C +NI+ECQS+PC ATC
Sbjct: 1339 GTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATC 1398
Query: 843 VDEINGYRCSCPPGRAGPRCQ 863
VDE+N Y C C PG +G RC+
Sbjct: 1399 VDELNSYSCKCQPGFSGKRCE 1419
Score = 194 bits (492), Expect = 6e-49
Identities = 92/247 (37%), Positives = 121/247 (48%), Gaps = 25/247 (10%)
Query: 388 ECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYC 447
EC NPC GTC G+ C+CP + G C+ D +EC PCLN CK+L+G + C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
Query: 448 DCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP 506
+C G+ G C N+N+C C + G C D V GY+C C +GF G HCE E +EC S+P
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNP 1315
Query: 507 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 566
C + +CED GF C CP GF G C +VD C PC+NGA C + + C C F
Sbjct: 1316 CLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGF 1375
Query: 567 GGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDS 626
G +C + C CR CV + ++SC C
Sbjct: 1376 TGSHCELNINECQSNPCR-----------------------NQATCVDEL-NSYSCKCQP 1411
Query: 627 GFTGTYC 633
GF+G C
Sbjct: 1412 GFSGKRC 1418
Score = 188 bits (478), Expect = 2e-47
Identities = 83/253 (32%), Positives = 115/253 (45%), Gaps = 24/253 (9%)
Query: 501 ECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYC 560
EC +PCH+ G C+ L G+ C CP G++G CE D+D C P PC N C +L G++ C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
Query: 561 ACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF 620
CP + G+ C C C G GV G +
Sbjct: 1256 ECPSGYTGQRCEENINECSSSPCL------------NKGICVDGVAG------------Y 1291
Query: 621 SCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680
C C GF G +C +++C PC N C D+V F C CP G+ G C N ++CL
Sbjct: 1292 RCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLS 1351
Query: 681 DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPP 740
PC + C D N F C C G+ G C +C + C N TC D +++ C C P
Sbjct: 1352 QPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQP 1411
Query: 741 GWKGSTCAVAKNS 753
G+ G C +++
Sbjct: 1412 GFSGKRCETEQST 1424
Score = 188 bits (477), Expect = 3e-47
Identities = 85/229 (37%), Positives = 127/229 (55%), Gaps = 6/229 (2%)
Query: 275 ECVPYPGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQY 331
EC P G+C + + C C + GL C+ D++ C S PC N G C + ++
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDEC-SPLPCLNNGVCKDLV-GEF 1253
Query: 332 RCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECAS 391
C CP GY+G+ CE+ + C+S+PC N G C + +G+ C C G+ G C +++EC S
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
Query: 392 NPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIP 451
NPC C DQV GF C CP ++G C + +EC +PC N +CK+ + C C
Sbjct: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
Query: 452 GWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELER 499
G+ G +C +N+N+C+ C++ TC D +N Y C C GF G+ CE E+
Sbjct: 1374 GFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQ 1422
Score = 132 bits (331), Expect = 3e-30
Identities = 73/217 (33%), Positives = 108/217 (49%), Gaps = 17/217 (7%)
Query: 222 TCDQYGNK---ACMDGWMGKECKEAV--CKQGCNLLHGGCT-VPGE--CRCSYGWQGRFC 273
TC Q G C G+ G +C+ + C L +G C + GE C C G+ G+ C
Sbjct: 1207 TCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSGYTGQRC 1266
Query: 274 D----ECVPYPGCVHGSCVE---PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA 326
+ EC P G CV+ ++C C + GL C+ ++N C S +PC N C
Sbjct: 1267 EENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS-NPCLNNAVC-ED 1324
Query: 327 EPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
+ + C CP G+ G C K C S PC NG +C + + F C C +G++G C L+I
Sbjct: 1325 QVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNI 1384
Query: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLD 423
+EC SNPC TCVD+++ + C C + G C+ +
Sbjct: 1385 NECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETE 1421
Score = 82.8 bits (203), Expect = 2e-15
Identities = 98/374 (26%), Positives = 134/374 (35%), Gaps = 42/374 (11%)
Query: 618 GNFSC-ICDSGFTGTYCHE-NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 675
G C +C SG Y H NI DC Q C+ G ++ CP G +
Sbjct: 1028 GQLECKLCPSGMYTEYIHSRNISDCKAQ-CKQGTYSYSGLETCES-CPLGTYQPKFGSR- 1084
Query: 676 NDCLPDPCHSRGRCYDLVNDFYCA--CDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDT 733
CL P ++ VN C C +G SR + C ++G
Sbjct: 1085 -SCLSCPENTSTVKRGAVNISACGVPCPEGK-----FSRSGLMPCHPCPRDYYQPNAGKA 1138
Query: 734 FRCACPPGWKGSTCAVAKNS----SCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 789
F ACP + G+T S S + V AS I + H
Sbjct: 1139 FCLACP--FYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFH- 1195
Query: 790 TNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY 849
+C PC+N G C + C C G+ G C +IDEC PC C D + +
Sbjct: 1196 --ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEF 1253
Query: 850 RCSCPPGRAGPRCQEVIGFGRS--CWSRGTPFPHGSSWVEDCNSCRCLDG----RRDCSK 903
C CP G G RC+E I S C ++G + + C C+ G +
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGY-----RCTCVKGFVGLHCETEV 1308
Query: 904 VWCGWKPCL----LAGQPEALSAQCP---LGQRCLEKAPGQCLRPPCEAWGECGAEEPPS 956
C PCL Q +CP LG RC K +CL PC+ C + S
Sbjct: 1309 NECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRC-GKNVDECLSQPCKNGATC-KDGANS 1366
Query: 957 TPCLPRSGHLDNNC 970
CL +G ++C
Sbjct: 1367 FRCLCAAGFTGSHC 1380
Score = 82.4 bits (202), Expect = 2e-15
Identities = 44/133 (33%), Positives = 62/133 (46%), Gaps = 14/133 (10%)
Query: 218 FGHYTCDQYGNKACMDG--WMGKECKEAVCKQGCNLLHGG-CTVPGECRCSYGWQGRFCD 274
+ Y + + C++ W AVC+ C +GG C P C C GW GR C+
Sbjct: 3443 YSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQ--NGGICQRPNACSCPEGWMGRLCE 3500
Query: 275 ECVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRC 333
E + C++G CV P+QC+C W G C + C S PC NGG C+ RC
Sbjct: 3501 EPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAV--CQS--PCLNGGKCVRPN----RC 3552
Query: 334 TCPDGYSGRNCEK 346
C ++G NC +
Sbjct: 3553 HCLSSWTGHNCSR 3565
Score = 80.1 bits (196), Expect = 1e-14
Identities = 56/167 (33%), Positives = 74/167 (44%), Gaps = 36/167 (21%)
Query: 220 HYTCDQYGNK---ACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDEC 276
HY QYG+ +C G+M + +VC L +G T P CR
Sbjct: 3431 HY---QYGDMITYSCYSGYMLEGFLRSVC-----LENGTWTSPPICRA-----------V 3471
Query: 277 VPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCP 336
+P G C P C+C W G LC++ + PC NGG C+ Y+C CP
Sbjct: 3472 CRFPCQNGGICQRPNACSCPEGWMGRLCEEPICIL----PCLNGGRCVAP----YQCDCP 3523
Query: 337 DGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCA 383
G++G C A C S PC NGG C P+ CHC S W+G C+
Sbjct: 3524 PGWTGSRCHTA--VCQS-PCLNGGKCVR-PN--RCHCLSSWTGHNCS 3564
Score = 74.7 bits (182), Expect = 5e-13
Identities = 40/105 (38%), Positives = 49/105 (46%), Gaps = 16/105 (15%)
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPS 375
PC NGG C C+CP+G+ GR CE E C PC NGG C + ++C CP
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCE--EPICIL-PCLNGGRC---VAPYQCDCPP 3524
Query: 376 GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATC 420
GW+G C + +PC GG CV C C W G C
Sbjct: 3525 GWTGSRCHTAV---CQSPCLNGGKCVRP---NRCHCLSSWTGHNC 3563
Score = 72.0 bits (175), Expect = 3e-12
Identities = 37/106 (34%), Positives = 49/106 (46%), Gaps = 16/106 (15%)
Query: 682 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 741
PC + G C C+C +GW G+ C E C NGG C ++C CPPG
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLC---EEPICILPCLNGGRCVAP---YQCDCPPG 3525
Query: 742 WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCT 787
W GS C +++ +PC+NGG CV C C W G C+
Sbjct: 3526 WTGSRC----HTAVCQSPCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
Score = 71.6 bits (174), Expect = 4e-12
Identities = 42/105 (40%), Positives = 49/105 (46%), Gaps = 15/105 (14%)
Query: 644 PCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDG 703
PC+NGG C +A C CP GW G LC+ P L PC + GRC V + C C G
Sbjct: 3475 PCQNGGIC-QRPNA--CSCPEGWMGRLCE-EPICIL--PCLNGGRC---VAPYQCDCPPG 3525
Query: 704 WKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCA 748
W G CH+ Q C NGG C RC C W G C+
Sbjct: 3526 WTGSRCHTAVCQS---PCLNGGKCVRPN---RCHCLSSWTGHNCS 3564
Score = 69.3 bits (168), Expect = 2e-11
Identities = 56/184 (30%), Positives = 67/184 (36%), Gaps = 37/184 (20%)
Query: 698 CACDDGWKGKTCHSREFQCD----AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 753
C D+ W + + C G Y GD +C + G S
Sbjct: 3398 CNPDETWTQTSAKCEKISCGPPAHVENAIARGVHYQYGDMITYSC---YSGYMLEGFLRS 3454
Query: 754 SCLPN---------------PCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 798
CL N PC NGG C A C C +GW GR C C LPC
Sbjct: 3455 VCLENGTWTSPPICRAVCRFPCQNGGICQRPNA---CSCPEGWMGRLCEEPI--CI-LPC 3508
Query: 799 YNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRA 858
NGG CV ++C+C PG+ G C + CQ SPC G CV RC C
Sbjct: 3509 LNGGRCVAP---YQCDCPPGWTGSRCHTAV--CQ-SPCLNGGKCV---RPNRCHCLSSWT 3559
Query: 859 GPRC 862
G C
Sbjct: 3560 GHNC 3563
Score = 69.3 bits (168), Expect = 2e-11
Identities = 39/107 (36%), Positives = 48/107 (44%), Gaps = 14/107 (13%)
Query: 393 PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPG 452
PC GG C C CPE W+G C+ PCLN C + Y CDC PG
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPICIL---PCLNGGRC---VAPYQCDCPPG 3525
Query: 453 WKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELER 499
W G CH V C+ C +GG C V +C C + G +C +R
Sbjct: 3526 WTGSRCHTAV--CQSPCLNGGKC---VRPNRCHCLSSWTGHNCSRKR 3567
Score = 68.2 bits (165), Expect = 5e-11
Identities = 41/111 (36%), Positives = 52/111 (46%), Gaps = 15/111 (13%)
Query: 465 CRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 524
CR CQ+GG C+ C CP G+ GR CE + PC +GG C + C C
Sbjct: 3472 CRFPCQNGGICQ---RPNACSCPEGWMGRLCE---EPICILPCLNGGRC---VAPYQCDC 3522
Query: 525 PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPR 575
P G++G C V C+ SPC NG +C C C + G NCS R
Sbjct: 3523 PPGWTGSRCHTAV--CQ-SPCLNGGKCVR---PNRCHCLSSWTGHNCSRKR 3567
Score = 58.5 bits (140), Expect = 4e-08
Identities = 47/167 (28%), Positives = 61/167 (36%), Gaps = 47/167 (28%)
Query: 507 CHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDF 566
C+SG + E S P+C +C PC+NG C C+CP+ +
Sbjct: 3442 CYSGYMLEGFLRSVCLENGTWTSPPICRA---VCR-FPCQNGGICQRPNA---CSCPEGW 3494
Query: 567 GGKNCSVPR--EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 624
G+ C P PC G GRCV+ + C C
Sbjct: 3495 MGRLCEEPICILPCLNG----------------------------GRCVAP----YQCDC 3522
Query: 625 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 671
G+TG+ CH + PC NGG C V RC C S W G C
Sbjct: 3523 PPGWTGSRCHTAV---CQSPCLNGGKC---VRPNRCHCLSSWTGHNC 3563
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/81 (38%), Positives = 41/81 (50%), Gaps = 12/81 (14%)
Query: 506 PCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDD 565
PC +GG+C+ C CP+G+ G LCE + + PC NG RC Y C CP
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPICIL---PCLNGGRCV---APYQCDCPPG 3525
Query: 566 FGGKNC--SVPREPC-PGGAC 583
+ G C +V + PC GG C
Sbjct: 3526 WTGSRCHTAVCQSPCLNGGKC 3546
Score = 49.7 bits (117), Expect = 2e-05
Identities = 39/109 (35%), Positives = 45/109 (41%), Gaps = 20/109 (18%)
Query: 797 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 856
PC NGGIC C C G+ G C I C PC G CV Y+C CPPG
Sbjct: 3475 PCQNGGICQRPN---ACSCPEGWMGRLCEEPI--C-ILPCLNGGRCVAP---YQCDCPPG 3525
Query: 857 RAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDG--RRDCSK 903
G RC + C S P +G V N C CL +CS+
Sbjct: 3526 WTGSRCHTAV-----CQS---PCLNGGKCVRP-NRCHCLSSWTGHNCSR 3565
Score = 44.3 bits (103), Expect = 7e-04
Identities = 41/142 (28%), Positives = 54/142 (38%), Gaps = 17/142 (11%)
Query: 691 DLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTC------YDSGDTFRC-ACPPGWK 743
D+V+ Y CD+G K C R C T + C Y G + C ACP G
Sbjct: 273 DMVHCSYL-CDEG---KDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTY 328
Query: 744 GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGI 803
+ SSC+P P N + GS + C+CR+G+ T C L G
Sbjct: 329 KPEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGY 388
Query: 804 CVDGV--NWFRCECA----PGF 819
+ N F C PGF
Sbjct: 389 FIQNTCNNHFNAACGVRCHPGF 410
Score = 39.7 bits (91), Expect = 0.018
Identities = 47/193 (24%), Positives = 68/193 (35%), Gaps = 19/193 (9%)
Query: 303 LCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC 362
LCD+ + C C G + C C GY G+ + AC S GS
Sbjct: 280 LCDEGKDCCDRMGSCKCG-----THTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
Query: 363 HEVPSGFECHCPSGWSGPTCALDID-ECASNPCAAGGTCVDQVDGFECICPEQ---WVGA 418
+ S C + S P D C A+G TC ++ + P + ++
Sbjct: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTC--ELVHCPALKPPENGYFIQN 392
Query: 419 TCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPG--WKGINCHINVNDC--RGQCQHGG- 473
TC N G C F +L+G C+P W G + V C Q +HG
Sbjct: 393 TCNNHFNAACGVRCHPGF---DLVGSSIILCLPNGLWSGSESYCRVRTCPHLRQPKHGHI 449
Query: 474 TCKDLVNGYQCVC 486
+C Y+ C
Sbjct: 450 SCSTREMLYKTTC 462
Score = 39.3 bits (90), Expect = 0.024
Identities = 63/281 (22%), Positives = 93/281 (33%), Gaps = 30/281 (10%)
Query: 512 LCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
L EDL G LC+ D C+ +C G + C C + GK
Sbjct: 260 LHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRM---GSCKCGTHTGHFECICEKGYYGKGL 316
Query: 572 SVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNF--SCICDSGF- 628
CP G + G PG +S + P S PG C+C G+
Sbjct: 317 QYECTACPSGTYK---------PEGSPGGISSCIPCPDENHTSPPGSTSPEDCVCREGYR 367
Query: 629 -TGTYCHENIDDCLGQPCRNG----GTCIDEVD-AFRCFCPSGWEGELCDTNPNDCLPDP 682
+G C E + +P NG TC + + A C G+ +L ++ CLP+
Sbjct: 368 ASGQTC-ELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGF--DLVGSSIILCLPNG 424
Query: 683 CHSRGRCYDLVNDFYCACDDGWKGKTCHSRE--FQCDAYTCSNGGTCYDSGDTFRCACPP 740
S Y V +C +RE ++ + G + D C
Sbjct: 425 LWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNS 484
Query: 741 GWKG-STCAVAKNSSCLPNP---CVNGGTCVGSGASFSCIC 777
W G V ++ S P ++ C A F IC
Sbjct: 485 QWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTIC 525
Score = 38.5 bits (88), Expect = 0.040
Identities = 21/47 (44%), Positives = 26/47 (55%), Gaps = 4/47 (8%)
Query: 531 PLCEVDVDLCEP-SPCRNGARCYNLEGDYYCAC--PDDFGGKNCSVP 574
P C +DVD C S C A C N++G Y C+C P GKNC+ P
Sbjct: 1741 PSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEP 1786
Score = 37.7 bits (86), Expect = 0.068
Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 15/103 (14%)
Query: 779 DGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQ-SSPCA 837
D + G T T+ N+ L + C D +W P C +++DEC S C+
Sbjct: 1705 DFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSW-------NGVSPSC-LDVDECAVGSDCS 1756
Query: 838 YGATCVDEINGYRCSCPPGRA--GPRCQEVIGFGRSCWSRGTP 878
A+C++ Y CSC P G C E I C + G P
Sbjct: 1757 EHASCLNVDGSYICSCVPPYTGDGKNCAEPI----KCKAPGNP 1795
Score = 35.8 bits (81), Expect = 0.26
Identities = 17/41 (41%), Positives = 22/41 (53%), Gaps = 2/41 (4%)
Query: 416 VGATCQLDANECE-GKPCLNAFSCKNLIGGYYCDCIPGWKG 455
V +C LD +EC G C SC N+ G Y C C+P + G
Sbjct: 1739 VSPSC-LDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
Score = 35.4 bits (80), Expect = 0.34
Identities = 42/192 (21%), Positives = 66/192 (34%), Gaps = 27/192 (14%)
Query: 608 PHGRCVSQ---PGGNFSCICDSGFTGTYCHENIDDCLGQP---CRNGGTC---IDEVDAF 658
PH R S+ PG + CD GF +G P C N G + +
Sbjct: 1639 PHLRTASEDLKPGSKVNLFCDPGF----------QLVGNPVQYCLNQGQWTQPLPHCERI 1688
Query: 659 RCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND--FYCACDDGWKG--KTCHSREF 714
C P E + + Y L+ D +C + W G +C +
Sbjct: 1689 SCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDE 1748
Query: 715 QCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSC-LPNPCVNG---GTCVGSG 770
CS +C + ++ C+C P + G A+ C P NG G G
Sbjct: 1749 CAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808
Query: 771 ASFSCICRDGWE 782
A + C++G++
Sbjct: 1809 AEVTFSCQEGYQ 1820
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/101 (23%), Positives = 41/101 (40%), Gaps = 21/101 (20%)
Query: 456 INCHINVNDCRGQCQHGGTCK--DLVNGYQCVCPRGFGGRHCELERDECASSPC----HS 509
++C ++ + C G+CK ++C+C +G+ G+ + E C S
Sbjct: 275 VHCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSP 334
Query: 510 GGL--CEDLADGFH-----------CHCPQGF--SGPLCEV 535
GG+ C D H C C +G+ SG CE+
Sbjct: 335 GGISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCEL 375
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 222 bits (565), Expect = 2e-57
Identities = 89/235 (37%), Positives = 128/235 (54%), Gaps = 5/235 (2%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290
C+ G G+ + C C+L HG C G CRC GW+G C+ CV PGC HG+C +P
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
WQC C + W G CDKD + C + PC NGG C+ +Y C C G+ GR+CE+
Sbjct: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
Query: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
C +PC NGG C + F C C G+ G C +++D+C PCA G TC+D ++
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 406 GFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI 460
F C+CPE + G C ++ ++C +PC C++ + + C C G+ G C +
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
Score = 171 bits (433), Expect = 4e-42
Identities = 91/256 (35%), Positives = 117/256 (45%), Gaps = 38/256 (14%)
Query: 460 INVNDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 517
+ +DC C HG D C C G+ G HCE C P G C
Sbjct: 24 VRADDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ-- 73
Query: 518 DGFHCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPR 575
+ C C G++G C+ D +C SPC+NG +C Y+ G+Y+C C F G++C
Sbjct: 74 -PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
Query: 576 EPCP--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 633
PC G CR C D G + NF+C C GF G C
Sbjct: 133 GPCEQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARC 171
Query: 634 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693
N+DDCL +PC NG TC+D ++ F C CP G+ G C N +DC PC RC D V
Sbjct: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV 231
Query: 694 NDFYCACDDGWKGKTC 709
+DF C C G+ GKTC
Sbjct: 232 HDFDCLCPSGYGGKTC 247
Score = 171 bits (433), Expect = 4e-42
Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
DDC G C + C C GWEG C+ C+ P G C+ +
Sbjct: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
Query: 698 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 755
C C GW GK C E C + C NGG C YD G + C C PG+ G C K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
Query: 756 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 810
+PC NGG C G +F+C C G+ G C N +DC PC NG C+DG+N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
Query: 811 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
F C C GFAG C IN+D+C S PC GA C D ++ + C CP G G C+ V+
Sbjct: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
Score = 159 bits (401), Expect = 2e-38
Identities = 88/258 (34%), Positives = 119/258 (46%), Gaps = 19/258 (7%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
C+S+ G C P G C C GW G C + C P GTC ++CI
Sbjct: 29 CSSHCDLAHGCC--APDG-SCRCDPGWEGLHC----ERCVRMPGCQHGTCHQP---WQCI 78
Query: 411 CPEQWVGATCQLDANECEGK-PCLNAFSCKNLIGG-YYCDCIPGWKGINCHINVNDCR-- 466
C W G C D + C + PC N C GG Y+C C+PG+ G +C C
Sbjct: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
Query: 467 -GQCQHGGTCKD---LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHC 522
C++GG C+D + C C GF G CE+ D+C PC +G C D + F C
Sbjct: 139 GSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
Query: 523 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 582
CP+GF+G C +++D C PC+ GARC + D+ C CP +GGK C + P P
Sbjct: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-PVPDPP 257
Query: 583 CRVIDGCGSDAGPGMPGT 600
V G + +P T
Sbjct: 258 TTVDTPLGPTSAVVVPAT 275
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/224 (28%), Positives = 83/224 (37%), Gaps = 31/224 (13%)
Query: 764 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 823
G C G SC C GWEG C C +P G C ++C C G+AG
Sbjct: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
Query: 824 CRINIDECQS-SPCAYGATCVDEING-YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH 881
C + C + SPC G C+ + G Y C C PG G C+ G C G+P +
Sbjct: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRN 144
Query: 882 GSSWVEDCN-----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG- 927
G +D +CRCL G R + + C +PC S CP G
Sbjct: 145 GGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGF 204
Query: 928 -QRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
R C PC+ C + CL SG+ C
Sbjct: 205 AGRFCTINLDDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 222 bits (565), Expect = 2e-57
Identities = 89/235 (37%), Positives = 128/235 (54%), Gaps = 5/235 (2%)
Query: 231 CMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP 290
C+ G G+ + C C+L HG C G CRC GW+G C+ CV PGC HG+C +P
Sbjct: 15 CILGAPGQPVRADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQP 74
Query: 291 WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHA 350
WQC C + W G CDKD + C + PC NGG C+ +Y C C G+ GR+CE+
Sbjct: 75 WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGP 134
Query: 351 C--TSNPCANGGSCHE---VPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD 405
C +PC NGG C + F C C G+ G C +++D+C PCA G TC+D ++
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 406 GFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHI 460
F C+CPE + G C ++ ++C +PC C++ + + C C G+ G C +
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCEL 249
Score = 171 bits (433), Expect = 4e-42
Identities = 91/256 (35%), Positives = 117/256 (45%), Gaps = 38/256 (14%)
Query: 460 INVNDCRGQCQ--HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLA 517
+ +DC C HG D C C G+ G HCE C P G C
Sbjct: 24 VRADDCSSHCDLAHGCCAPD----GSCRCDPGWEGLHCE----RCVRMPGCQHGTCHQ-- 73
Query: 518 DGFHCHCPQGFSGPLCEVDVDLCEP-SPCRNGARC-YNLEGDYYCACPDDFGGKNCSVPR 575
+ C C G++G C+ D +C SPC+NG +C Y+ G+Y+C C F G++C
Sbjct: 74 -PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKA 132
Query: 576 EPCP--GGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYC 633
PC G CR C D G + NF+C C GF G C
Sbjct: 133 GPCEQAGSPCRNGGQCQDDQGFAL---------------------NFTCRCLVGFVGARC 171
Query: 634 HENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLV 693
N+DDCL +PC NG TC+D ++ F C CP G+ G C N +DC PC RC D V
Sbjct: 172 EVNVDDCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRV 231
Query: 694 NDFYCACDDGWKGKTC 709
+DF C C G+ GKTC
Sbjct: 232 HDFDCLCPSGYGGKTC 247
Score = 171 bits (433), Expect = 4e-42
Identities = 91/236 (38%), Positives = 113/236 (47%), Gaps = 18/236 (7%)
Query: 638 DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFY 697
DDC G C + C C GWEG C+ C+ P G C+ +
Sbjct: 27 DDCSSHCDLAHGCCAPDGS---CRCDPGWEGLHCER----CVRMPGCQHGTCHQ---PWQ 76
Query: 698 CACDDGWKGKTCHSREFQCDAYT-CSNGGTC-YDSGDTFRCACPPGWKGSTCAVAKNSSC 755
C C GW GK C E C + C NGG C YD G + C C PG+ G C K C
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCE-RKAGPC 135
Query: 756 --LPNPCVNGGTCV---GSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNW 810
+PC NGG C G +F+C C G+ G C N +DC PC NG C+DG+N
Sbjct: 136 EQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINR 195
Query: 811 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI 866
F C C GFAG C IN+D+C S PC GA C D ++ + C CP G G C+ V+
Sbjct: 196 FSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL 251
Score = 159 bits (401), Expect = 2e-38
Identities = 88/258 (34%), Positives = 119/258 (46%), Gaps = 19/258 (7%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECI 410
C+S+ G C P G C C GW G C + C P GTC ++CI
Sbjct: 29 CSSHCDLAHGCC--APDG-SCRCDPGWEGLHC----ERCVRMPGCQHGTCHQP---WQCI 78
Query: 411 CPEQWVGATCQLDANECEGK-PCLNAFSCKNLIGG-YYCDCIPGWKGINCHINVNDCR-- 466
C W G C D + C + PC N C GG Y+C C+PG+ G +C C
Sbjct: 79 CHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQA 138
Query: 467 -GQCQHGGTCKD---LVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHC 522
C++GG C+D + C C GF G CE+ D+C PC +G C D + F C
Sbjct: 139 GSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSC 198
Query: 523 HCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA 582
CP+GF+G C +++D C PC+ GARC + D+ C CP +GGK C + P P
Sbjct: 199 LCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVL-PVPDPP 257
Query: 583 CRVIDGCGSDAGPGMPGT 600
V G + +P T
Sbjct: 258 TTVDTPLGPTSAVVVPAT 275
Score = 65.9 bits (159), Expect = 2e-10
Identities = 64/224 (28%), Positives = 83/224 (37%), Gaps = 31/224 (13%)
Query: 764 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD 823
G C G SC C GWEG C C +P G C ++C C G+AG
Sbjct: 38 GCCAPDG---SCRCDPGWEGLHCER----CVRMPGCQHGTCHQP---WQCICHSGWAGKF 87
Query: 824 CRINIDECQS-SPCAYGATCVDEING-YRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH 881
C + C + SPC G C+ + G Y C C PG G C+ G C G+P +
Sbjct: 88 CDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAG---PCEQAGSPCRN 144
Query: 882 GSSWVEDCN-----SCRCLDG----RRDCSKVWCGWKPCLLAGQ----PEALSAQCPLG- 927
G +D +CRCL G R + + C +PC S CP G
Sbjct: 145 GGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGINRFSCLCPEGF 204
Query: 928 -QRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
R C PC+ C + CL SG+ C
Sbjct: 205 AGRFCTINLDDCASRPCQRGARC-RDRVHDFDCLCPSGYGGKTC 247
>gi|110347437 latent transforming growth factor beta binding protein 4
isoform c [Homo sapiens]
Length = 1557
Score = 221 bits (563), Expect = 3e-57
Identities = 208/679 (30%), Positives = 282/679 (41%), Gaps = 139/679 (20%)
Query: 351 CTSNPCANG-GSCHEVPSGFECHCPSGW----SGPTCALDIDEC--ASNPCAAGGTCVDQ 403
C NP G G C PSG+ C C SG+ G C +D+DEC PCA G C +
Sbjct: 482 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPG-RCENS 539
Query: 404 VDGFECIC-PEQWVG---ATCQLDANECEG--KPCLNAFSCKNLIGGYYCDCIPGWK--- 454
F C+C P G A C LD +EC PC + C+N G + C C G++
Sbjct: 540 PGSFRCVCGPGFRAGPRAAEC-LDVDECHRVPPPC-DLGRCENTPGSFLCVCPAGYQAAP 597
Query: 455 -GINCHINVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSG 510
G +C +V++C G C G CK+L ++CVCP GF G CE + DECA P G
Sbjct: 598 HGASCQ-DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCG 655
Query: 511 -GLCEDLADGFHCHCPQGFS----GPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACP 563
G C++ A FHC CP GF G C+ DVD C P PC G RC N EG + C CP
Sbjct: 656 PGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGSFQCVCP 713
Query: 564 DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC- 622
F G C +D C + + P CV+ PG +F C
Sbjct: 714 MGFQPNTA--------GSECEDVDECENH------------LACPGQECVNSPG-SFQCR 752
Query: 623 ICDSGFTGTYCHE----NIDDCLG--QPCRNGGTCIDEVDAFRCFC------PSGWEGEL 670
C SG + H ++D+C PC G C + +FRC C PSG G
Sbjct: 753 TCPSGH---HLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC 809
Query: 671 CDTNPNDCLP-DPCHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGG 725
D N +CL D C G C + F C C G++ G +C + +C G
Sbjct: 810 ADVN--ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD-ECSEEDLCQSG 866
Query: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP-------NPCVNGGT-CVGSGASFSCI- 776
C ++ +F C CPPG + A +SCL P + G C S S+ C+
Sbjct: 867 ICTNTDGSFECICPPGHR----AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 922
Query: 777 -CRDGWEGR---TCTHNTNDCN---PLPCYNGGICVDGVNWFRCE--CAPGFA---GPDC 824
C G+ TC + ++C P C C + +RC C PG+ G C
Sbjct: 923 DCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCTPACDPGYQPTPGGGC 980
Query: 825 RINIDECQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+ ++DEC++ S C A C + ++C C G G R GR C
Sbjct: 981 Q-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR------DGRHC----------- 1022
Query: 884 SWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPC 943
D N C L G CG L + CP + G+C+ P
Sbjct: 1023 ---VDVNECETLQG-------VCG--AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1070
Query: 944 EAWGECGAE-EPPSTPCLP 961
A G++ + P++P LP
Sbjct: 1071 SAGTFPGSQPQAPASPVLP 1089
Score = 176 bits (445), Expect = 2e-43
Identities = 199/797 (24%), Positives = 277/797 (34%), Gaps = 191/797 (23%)
Query: 249 CNLLHGGC-TVPGE--CRCSYGWQ----GRFC---DECVPYPG-CVHGSCVE---PWQCN 294
C+L G C PG C C G+Q G C DEC PG C G+C ++C
Sbjct: 573 CDL--GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 630
Query: 295 CETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN----CEKAEHA 350
C + G C++D++ C P G C N + C CP G+ R C+ +
Sbjct: 631 CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTA-GSFHCACPAGFRSRGPGAPCQDVDEC 689
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCAAGGTCVDQVDG 406
S P G C F+C CP G+ +G C D+DEC ++ G CV+
Sbjct: 690 ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGS 748
Query: 407 FEC-ICPE--QWVGATCQLDANECEG--KPCLNAFSCKNLIGGYYCDCIPGWKGINCH-- 459
F+C CP C D +EC PC C N G + C C PG++ +
Sbjct: 749 FQCRTCPSGHHLHRGRCT-DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 807
Query: 460 --INVNDC-RGQ-CQHGGTCKDLVNGYQCVCPRGFG----GRHCELERDECASSPCHSGG 511
+VN+C G C G C + + C C G+ G C L+ DEC+ G
Sbjct: 808 PCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSG 866
Query: 512 LCEDLADGFHCHCPQGF-SGPLCE--VDVDLC-EPSPCRNGA-RCYNLEGDYYCA----- 561
+C + F C CP G +GP +DVD C E P G+ RC N G Y C
Sbjct: 867 ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 926
Query: 562 ---------CPD-----DFGGKNCSVPR------------------EPCPGGACRVIDGC 589
C D ++G + C R +P PGG C+ +D C
Sbjct: 927 GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDEC 986
Query: 590 GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT----GTYCH----------- 634
+ + CG H C + PG +F C+CD G+ G +C
Sbjct: 987 RNRS-----------FCGAHAVCQNLPG-SFQCLCDQGYEGARDGRHCVDVNECETLQGV 1034
Query: 635 ------ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPN------------ 676
EN++ C N D + RC P G + P
Sbjct: 1035 CGAALCENVEGSFLCVCPNSPEEFDPMTG-RCVPPRTSAGTFPGSQPQAPASPVLPARPP 1093
Query: 677 ---------------------DCL-----PDPCHSRGRCYDLVNDFYCACDDGWKG---- 706
+C PD C + + C +GW
Sbjct: 1094 PPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRI 1153
Query: 707 KTCHSREFQCDAYTCSNG-GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGT 765
+ C E C +G G SGD C + ++ C G
Sbjct: 1154 QQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR-----DVDECQLFRDQVC------KSGV 1202
Query: 766 CVGSGASFSCICRDGWEGRT----CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA- 820
CV + +SC C +G+ T C N + P GG CV+ V + C C P
Sbjct: 1203 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1262
Query: 821 -GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPF 879
G R +E QS G C E+ G C + PR + C
Sbjct: 1263 DGSQRRCVSNESQSLDDNLG-VCWQEV-GADLVC----SHPRLDRQATYTECCCL----- 1311
Query: 880 PHGSSWVEDCNSCRCLD 896
+G +W DC C D
Sbjct: 1312 -YGEAWGMDCALCPAQD 1327
Score = 174 bits (442), Expect = 4e-43
Identities = 171/620 (27%), Positives = 243/620 (39%), Gaps = 112/620 (18%)
Query: 235 WMGKECKEAVCKQGCNLLHGGCTVPGEC---------RCSYGW----QGRFC---DEC-- 276
W G E E+ G + PG C C G+ QG C DEC
Sbjct: 467 WTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRR 526
Query: 277 VPYPGCVHGSCVEP---WQCNCETNW--GGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQ 330
VP P C G C ++C C + G + D++ C P + G C N P
Sbjct: 527 VP-PPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT-PGS 584
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANG-GSCHEVPSGFECHCPSGWSGPTCALD 385
+ C CP GY G +C+ + CT +P G G+C +P F C CP+G+ G C D
Sbjct: 585 FLCVCPAGYQAAPHGASCQDVDE-CTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 643
Query: 386 IDECASNPCAAG-GTCVDQVDGFECICP----EQWVGATCQLDANECEGKPCLNAFS-CK 439
+DECA P G G C + F C CP + GA CQ D +EC P + C+
Sbjct: 644 VDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYGRCE 702
Query: 440 NLIGGYYCDCIPGWK----GINCHINVNDCRGQCQ-HGGTCKDLVNGYQC-VCPRG---F 490
N G + C C G++ G C +V++C G C + +QC CP G
Sbjct: 703 NTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGHHLH 761
Query: 491 GGRHCELERDECASS--PCHSGGLCEDLADGFHCHC------PQGFSGPLCEVDVDLCEP 542
GR ++ DEC+S PC G C + F C C P G GP +V+ + E
Sbjct: 762 RGRCTDV--DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVN-ECLEG 818
Query: 543 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTA 601
C C N +G + C C + P P GA C +D C +
Sbjct: 819 DFCFPHGECLNTDGSFACTCAPGY---------RPGPRGASCLDVDECSEE------DLC 863
Query: 602 ASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLG-QPCRNGG-------TCID 653
SG+C + G+F CIC G ++ CL CR G C +
Sbjct: 864 QSGIC-------TNTDGSFECICPPGHR---AGPDLASCLDVDECRERGPALCGSQRCEN 913
Query: 654 EVDAFRCF--CPSGW----EGELCDTNP-NDCLPDPCHSRGRCYDLVNDFYC--ACDDGW 704
++RC C G+ EG D + + P+ C ++ RC + + C ACD G+
Sbjct: 914 SPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGY 972
Query: 705 K---GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGST----CAVAKNSSCLP 757
+ G C + + C C + +F+C C G++G+ C L
Sbjct: 973 QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1032
Query: 758 NPCVNGGTCVGSGASFSCIC 777
C C SF C+C
Sbjct: 1033 GVC-GAALCENVEGSFLCVC 1051
Score = 145 bits (365), Expect = 3e-34
Identities = 156/586 (26%), Positives = 233/586 (39%), Gaps = 121/586 (20%)
Query: 373 CPSGWS--GPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK 430
CP+G+ +C D+DECA+ G C + G+ C+CP+ ++ LD++
Sbjct: 277 CPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGFL-----LDSSRS--- 327
Query: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQC----QHGGTCKDLVNGYQ--- 483
SC I+ H+ +++ +G C + GG ++
Sbjct: 328 ------SC-----------------ISQHV-ISEAKGPCFRVLRDGGCSLPILRNITKQI 363
Query: 484 CVCPR--GFGGRHCEL--------ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 533
C C R GR C+L R+ C + P G +D + P G P
Sbjct: 364 CCCSRVGKAWGRGCQLCPPFGSEGFREICPAGP----GYHYSASDLRYNTRPLGQEPPRV 419
Query: 534 EVDVDLCEPSPCRNGA---RCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 590
+ P+ R A + LE PD G +P P
Sbjct: 420 SLSQPRTLPATSRPSAGFLPTHRLEPRPE-PRPDPRPGPELPLPSIP------------- 465
Query: 591 SDAGPGMPGTAASG--------VCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENID 638
+ GP +P + S VCGP GRC+S+P G ++C CDSGF GT C + +D
Sbjct: 466 AWTGPEIPESGPSSGMCQRNPQVCGP-GRCISRPSG-YTCACDSGFRLSPQGTRCID-VD 522
Query: 639 DC--LGQPCRNGGTCIDEVDAFRCFCPSGWE-----GELCDTNPNDCLPDPCHSRGRCYD 691
+C + PC G C + +FRC C G+ E D + +P PC GRC +
Sbjct: 523 ECRRVPPPCA-PGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC-DLGRCEN 580
Query: 692 LVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747
F C C G++ G +C + + G C + +FRC CP G++GS C
Sbjct: 581 TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSAC 640
Query: 748 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR---TCTHNTNDC--NPLPCYNGG 802
+ P G C + SF C C G+ R + ++C +P PC G
Sbjct: 641 EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPC-TYG 699
Query: 803 ICVDGVNWFRCECAPGF----AGPDCRINIDECQSSPCAYGATCVDEINGYRC-SCPPGR 857
C + F+C C GF AG +C ++DEC++ G CV+ ++C +CP G
Sbjct: 700 RCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGH 758
Query: 858 --AGPRCQEVIGFGRSCWSRGTPF-PHG-SSWVEDCNSCRCLDGRR 899
RC +V C S P PHG + E C C G R
Sbjct: 759 HLHRGRCTDV----DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 800
Score = 135 bits (339), Expect = 3e-31
Identities = 162/646 (25%), Positives = 240/646 (37%), Gaps = 138/646 (21%)
Query: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
G + E + C + T C ++ H C + C++ +C+
Sbjct: 699 GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP---GQECVNSPGSFQCR--T 753
Query: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP---WQCNCETNW-- 299
C G +L G CT EC C P HG C ++C+C +
Sbjct: 754 CPSGHHLHRGRCTDVDECSSG-------APPCGP-----HGHCTNTEGSFRCSCAPGYRA 801
Query: 300 --GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTS 353
G D+N C C G C+N + + CTC GY G +C + C+
Sbjct: 802 PSGRPGPCADVNECLEGDFCFPHGECLNTD-GSFACTCAPGYRPGPRGASCLDVDE-CSE 859
Query: 354 NPCANGGSCHEVPSGFECHCPSGW-SGPTCA--LDIDECASNPCAAGGT--CVDQVDGFE 408
G C FEC CP G +GP A LD+DEC A G+ C + +
Sbjct: 860 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYR 919
Query: 409 CI--C-PEQWVG--ATCQLDANECE--GKPCLNAFSCKNLIGGYYCD--CIPGWK---GI 456
C+ C P G TC D +EC+ G A C+N G Y C C PG++ G
Sbjct: 920 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 978
Query: 457 NCHINVNDCRGQ--CQHGGTCKDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSG 510
C +V++CR + C C++L +QC+C +G+ GRHC ++ +EC + G
Sbjct: 979 GCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCG 1036
Query: 511 G-LCEDLADGFHCHCPQG--------------------FSGPLCEVDVDLCEPS------ 543
LCE++ F C CP F G + P+
Sbjct: 1037 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1096
Query: 544 -----------PCRNGAR-CYNLEGDYYCACPDDFGGKNC-SVPREPCPGGACRVIDGCG 590
P +G R CY + A PD +V + C C V +G G
Sbjct: 1097 LPRRPSTPRQGPVGSGRRECY-----FDTAAPDACDNILARNVTWQEC---CCTVGEGWG 1148
Query: 591 SDAG----PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL---GQ 643
S PG +C PHGR P G+ S ++D+C Q
Sbjct: 1149 SGCRIQQCPGTETAEYQSLC-PHGRGYLAPSGDLSL-----------RRDVDECQLFRDQ 1196
Query: 644 PCRNGGTCIDEVDAFRCFCPSGWEGEL----CDTNPNDCLPDPCHSRGRCYDLVNDFYCA 699
C++G C++ + C+C +G+ C N +P GRC + V ++C
Sbjct: 1197 VCKSG-VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCT 1255
Query: 700 CD-----DGWKGKTCHSREFQCDAYTCSNGGTCY-DSGDTFRCACP 739
C+ DG + C S E Q N G C+ + G C+ P
Sbjct: 1256 CEPPLVLDG-SQRRCVSNESQS---LDDNLGVCWQEVGADLVCSHP 1297
Score = 120 bits (300), Expect = 1e-26
Identities = 192/782 (24%), Positives = 264/782 (33%), Gaps = 159/782 (20%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCE------------------------KAEHACT 352
C NGG C+ +PD RC CP ++G+ C+ A H
Sbjct: 90 CHNGGVCV--KPD--RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDD 145
Query: 353 SNPCANGGSCH-EVP--SGFECHCPSGWSGPTCALDIDECASNPCAAG------------ 397
+ A+ S H E P + H SGP D + A AA
Sbjct: 146 EHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQ 205
Query: 398 --------------GTCVDQVDGFECICPEQWV--------GATCQLDANECEGKPCLNA 435
G C ++ G EC P + GA ++C+ C
Sbjct: 206 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQ--LCSER 263
Query: 436 FSCKNLIGGYYCDCIPGWKGIN--CHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFG 491
+ C G++ +N C +V++C G+CQH G C + GY CVCP GF
Sbjct: 264 LGNSERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQH-GECANTRGGYTCVCPDGF- 320
Query: 492 GRHCELERDECASSPCHS---GGLCEDLADGFHCHCP--QGFSGPLCEVD---------V 537
+ R C S S G L DG C P + + +C
Sbjct: 321 --LLDSSRSSCISQHVISEAKGPCFRVLRDG-GCSLPILRNITKQICCCSRVGKAWGRGC 377
Query: 538 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP--CPGGACRVIDGCGSDAGP 595
LC P G R G Y D + +EP R + +
Sbjct: 378 QLCPPFG-SEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAG 436
Query: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC---- 651
+P P R +PG +TG E+ G RN C
Sbjct: 437 FLPTHRLEP--RPEPRPDPRPGPELPLPSIPAWTGPEIPES-GPSSGMCQRNPQVCGPGR 493
Query: 652 -IDEVDAFRCFCPSGW----EGELC-DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWK 705
I + C C SG+ +G C D + +P PC + GRC + F C C G++
Sbjct: 494 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFR 552
Query: 706 G----------KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK----GSTCAVAK 751
CH CD G C ++ +F C CP G++ G++C
Sbjct: 553 AGPRAAECLDVDECHRVPPPCDL------GRCENTPGSFLCVCPAGYQAAPHGASCQDVD 606
Query: 752 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDC--NPLPCYNGGICVDGVN 809
+ P C G C SF C+C G+ G C + ++C P PC G C +
Sbjct: 607 ECTQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAG 664
Query: 810 WFRCECAPGF----AGPDCRINIDECQSS--PCAYGATCVDEINGYRCSCP----PGRAG 859
F C C GF G C+ ++DEC S PC YG C + ++C CP P AG
Sbjct: 665 SFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGSFQCVCPMGFQPNTAG 722
Query: 860 PRCQEVIGFGR--SCWSRGTPFPHGSSWVEDCNSCRCLDGRR--DCSKVWCGWKPCLLAG 915
C++V +C + GS C S L R D + G PC G
Sbjct: 723 SECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 782
Query: 916 Q----PEALSAQCPLGQRCLEKAPGQCLRPPCEAWGEC--GAEEPPSTPCLPRSGHLDNN 969
+ C G R PG PC EC G P CL G
Sbjct: 783 HCTNTEGSFRCSCAPGYRAPSGRPG-----PCADVNECLEGDFCFPHGECLNTDGSFACT 837
Query: 970 CA 971
CA
Sbjct: 838 CA 839
Score = 66.6 bits (161), Expect = 1e-10
Identities = 151/650 (23%), Positives = 213/650 (32%), Gaps = 196/650 (30%)
Query: 451 PGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSG 510
PG G + C C +GG C V +C+CP F G+ C+L
Sbjct: 76 PGGPGFRAFL----CPLICHNGGVC---VKPDRCLCPPDFAGKFCQLHSSGARPPAPAVP 128
Query: 511 GLCEDL--------ADGFH-------------------CHCPQGFSGPLCEVDVDL---C 540
GL + D H H + SGP E D +
Sbjct: 129 GLTRSVYTMPLANHRDDEHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARA 188
Query: 541 EPSPCRNGARCYNL-------EGDYYCA-----CPDDFGGKNCSVPREPCPGGACRVIDG 588
E + A Y + E Y A C + G C+ P PG R +
Sbjct: 189 EAAARAEAAAPYTVLAQSAPREDGYSDASGFGYCFRELRGGECA---SPLPG--LRTQEV 243
Query: 589 CGSDAGPGMPGTAASGVCGP---HGRCVSQPGGNFSCICDSGF--TGTYCHENIDDCL-G 642
C AG G +C + VS P G C +GF C E++D+C G
Sbjct: 244 CCRGAGLAW-GVHDCQLCSERLGNSERVSAPDGP----CPTGFERVNGSC-EDVDECATG 297
Query: 643 QPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDP--CHSRGRCYDLVNDFYCAC 700
C++G C + + C CP G+ L D++ + C+ ++G C+ ++ D C+
Sbjct: 298 GRCQHG-ECANTRGGYTCVCPDGF---LLDSSRSSCISQHVISEAKGPCFRVLRDGGCSL 353
Query: 701 DDGWKGKTCHSREFQCDAYTCSNGGTCYDSG---------DTFRCACP--PGWKGSTCAV 749
R CS G + G + FR CP PG+ S +
Sbjct: 354 P--------ILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGFREICPAGPGYHYSASDL 405
Query: 750 AKNSSCL--------------------------------------PNPCVNGGTCVGSGA 771
N+ L P+P + S
Sbjct: 406 RYNTRPLGQEPPRVSLSQPRTLPATSRPSAGFLPTHRLEPRPEPRPDPRPGPELPLPSIP 465
Query: 772 SFSC--ICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGF----AGPDCR 825
+++ I G C N C P G C+ + + C C GF G C
Sbjct: 466 AWTGPEIPESGPSSGMCQRNPQVCGP------GRCISRPSGYTCACDSGFRLSPQGTRC- 518
Query: 826 INIDECQ--SSPCAYGATCVDEINGYRCSCPPG-RAGPRCQEVI------------GFGR 870
I++DEC+ PCA G C + +RC C PG RAGPR E + GR
Sbjct: 519 IDVDECRRVPPPCAPG-RCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGR 577
Query: 871 S----------CWSRGTPFPHGSSW--VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPE 918
C + PHG+S V++C L GR C + P
Sbjct: 578 CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNL------------PG 625
Query: 919 ALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDN 968
+ CP G R CE + A+EPP PC P G DN
Sbjct: 626 SFRCVCPAGFR----------GSACEEDVDECAQEPP--PCGP--GRCDN 661
Score = 44.7 bits (104), Expect = 6e-04
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 496 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCE----PSPCRNG 548
ELE +EC + G C + +GF C C G+ + VD++ C+ SP
Sbjct: 1464 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1523
Query: 549 ARCYNLEGDYYCACPDDF 566
ARC N +G + C C F
Sbjct: 1524 ARCLNTDGSFRCICRPGF 1541
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 336 PDG--YSGRNCE-----KAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALD 385
P+G Y+G E +AE + C NG C VP GF C C G+ +D
Sbjct: 1449 PEGGSYAGSLAEPYEELEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVD 1507
Query: 386 IDEC----ASNPCAAGGTCVDQVDGFECIC 411
I+EC A++P C++ F CIC
Sbjct: 1508 INECDEAEAASPLCVNARCLNTDGSFRCIC 1537
Score = 38.9 bits (89), Expect = 0.031
Identities = 31/99 (31%), Positives = 38/99 (38%), Gaps = 13/99 (13%)
Query: 731 GDTFRCACPPGWKGSTCAVAKNSS-CLPNPCVNGGTCVGSGASFSCICRD-GWEGRTCTH 788
G+ R P G C S C P T V SGA G+ C
Sbjct: 29 GERLRVRFTPVVCGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGGAAPGGPGFRAFLC-- 86
Query: 789 NTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 827
PL C+NGG+CV RC C P FAG C+++
Sbjct: 87 ------PLICHNGGVCVKP---DRCLCPPDFAGKFCQLH 116
Score = 38.1 bits (87), Expect = 0.052
Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQW---VGATCQLDANECEGKP-----CLNA 435
L+ +EC G CV +GF C C + + + +D NEC+ C+NA
Sbjct: 1465 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1524
Query: 436 FSCKNLIGGYYCDCIPGW 453
C N G + C C PG+
Sbjct: 1525 -RCLNTDGSFRCICRPGF 1541
Score = 38.1 bits (87), Expect = 0.052
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 792 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCR---INIDECQ----SSPCAYGATCVD 844
+C L G CV F C C G+ R ++I+EC +SP A C++
Sbjct: 1469 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLN 1528
Query: 845 EINGYRCSCPPGRA 858
+RC C PG A
Sbjct: 1529 TDGSFRCICRPGFA 1542
Score = 35.4 bits (80), Expect = 0.34
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 18/85 (21%)
Query: 721 CSNGGTCYDSGDTFRCACPPGWKG----------STCAVAKNSSCLPNPCVNGGTCVGSG 770
C+NG C + F C C G++ + C A+ +S L CVN C+ +
Sbjct: 1476 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL---CVNA-RCLNTD 1530
Query: 771 ASFSCICRDGWEGRTCTHNTNDCNP 795
SF CICR G+ TH + C P
Sbjct: 1531 GSFRCICRPGF---APTHQPHHCAP 1552
Score = 35.0 bits (79), Expect = 0.44
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 31/115 (26%)
Query: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----T 629
P E C ++DGC +GRCV P G F+C C G+ T
Sbjct: 1461 PYEELEAEECGILDGC------------------TNGRCVRVPEG-FTCRCFDGYRLDMT 1501
Query: 630 GTYCHENIDDC----LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680
C + I++C P C++ +FRC C G+ P+ C P
Sbjct: 1502 RMACVD-INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP---THQPHHCAP 1552
Score = 32.7 bits (73), Expect = 2.2
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 18/88 (20%)
Query: 545 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 604
C NG RC + + C C F G + R AC I+ C AAS
Sbjct: 1476 CTNG-RCVRVPEGFTCRC---FDGYRLDMTRM-----ACVDINECDE-------AEAASP 1519
Query: 605 VCGPHGRCVSQPGGNFSCICDSGFTGTY 632
+C + RC++ G +F CIC GF T+
Sbjct: 1520 LC-VNARCLNTDG-SFRCICRPGFAPTH 1545
Score = 31.6 bits (70), Expect = 4.9
Identities = 25/95 (26%), Positives = 32/95 (33%), Gaps = 16/95 (16%)
Query: 589 CGSDAGPGMPGTAASGVCGPHGRCV---SQPGGNFSCICDSGFTGTYCHENIDDCLGQPC 645
CG G G+ + C P PGG + GF C C
Sbjct: 41 CGLRCVHGPTGSRCTPTCAPRNATSVDSGAPGG--AAPGGPGFRAFLCP--------LIC 90
Query: 646 RNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680
NGG C V RC CP + G+ C + + P
Sbjct: 91 HNGGVC---VKPDRCLCPPDFAGKFCQLHSSGARP 122
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 14/94 (14%)
Query: 274 DECVPYPGCVHGSCV---EPWQCNC----ETNWGGLLCDKDLNYCG---SHHPCTNGGTC 323
+EC GC +G CV E + C C + + C D+N C + P C
Sbjct: 1468 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARC 1526
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+N + +RC C G++ + + H + P A
Sbjct: 1527 LNTD-GSFRCICRPGFAPTH--QPHHCAPARPRA 1557
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 221 bits (563), Expect = 3e-57
Identities = 208/679 (30%), Positives = 282/679 (41%), Gaps = 139/679 (20%)
Query: 351 CTSNPCANG-GSCHEVPSGFECHCPSGW----SGPTCALDIDEC--ASNPCAAGGTCVDQ 403
C NP G G C PSG+ C C SG+ G C +D+DEC PCA G C +
Sbjct: 512 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPG-RCENS 569
Query: 404 VDGFECIC-PEQWVG---ATCQLDANECEG--KPCLNAFSCKNLIGGYYCDCIPGWK--- 454
F C+C P G A C LD +EC PC + C+N G + C C G++
Sbjct: 570 PGSFRCVCGPGFRAGPRAAEC-LDVDECHRVPPPC-DLGRCENTPGSFLCVCPAGYQAAP 627
Query: 455 -GINCHINVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSG 510
G +C +V++C G C G CK+L ++CVCP GF G CE + DECA P G
Sbjct: 628 HGASCQ-DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCG 685
Query: 511 -GLCEDLADGFHCHCPQGFS----GPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACP 563
G C++ A FHC CP GF G C+ DVD C P PC G RC N EG + C CP
Sbjct: 686 PGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGSFQCVCP 743
Query: 564 DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC- 622
F G C +D C + + P CV+ PG +F C
Sbjct: 744 MGFQPNTA--------GSECEDVDECENH------------LACPGQECVNSPG-SFQCR 782
Query: 623 ICDSGFTGTYCHE----NIDDCLG--QPCRNGGTCIDEVDAFRCFC------PSGWEGEL 670
C SG + H ++D+C PC G C + +FRC C PSG G
Sbjct: 783 TCPSGH---HLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC 839
Query: 671 CDTNPNDCLP-DPCHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGG 725
D N +CL D C G C + F C C G++ G +C + +C G
Sbjct: 840 ADVN--ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD-ECSEEDLCQSG 896
Query: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP-------NPCVNGGT-CVGSGASFSCI- 776
C ++ +F C CPPG + A +SCL P + G C S S+ C+
Sbjct: 897 ICTNTDGSFECICPPGHR----AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 952
Query: 777 -CRDGWEGR---TCTHNTNDCN---PLPCYNGGICVDGVNWFRCE--CAPGFA---GPDC 824
C G+ TC + ++C P C C + +RC C PG+ G C
Sbjct: 953 DCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCTPACDPGYQPTPGGGC 1010
Query: 825 RINIDECQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+ ++DEC++ S C A C + ++C C G G R GR C
Sbjct: 1011 Q-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR------DGRHC----------- 1052
Query: 884 SWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPC 943
D N C L G CG L + CP + G+C+ P
Sbjct: 1053 ---VDVNECETLQG-------VCG--AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1100
Query: 944 EAWGECGAE-EPPSTPCLP 961
A G++ + P++P LP
Sbjct: 1101 SAGTFPGSQPQAPASPVLP 1119
Score = 176 bits (445), Expect = 2e-43
Identities = 199/797 (24%), Positives = 277/797 (34%), Gaps = 191/797 (23%)
Query: 249 CNLLHGGC-TVPGE--CRCSYGWQ----GRFC---DECVPYPG-CVHGSCVE---PWQCN 294
C+L G C PG C C G+Q G C DEC PG C G+C ++C
Sbjct: 603 CDL--GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 660
Query: 295 CETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN----CEKAEHA 350
C + G C++D++ C P G C N + C CP G+ R C+ +
Sbjct: 661 CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTA-GSFHCACPAGFRSRGPGAPCQDVDEC 719
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCAAGGTCVDQVDG 406
S P G C F+C CP G+ +G C D+DEC ++ G CV+
Sbjct: 720 ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGS 778
Query: 407 FEC-ICPE--QWVGATCQLDANECEG--KPCLNAFSCKNLIGGYYCDCIPGWKGINCH-- 459
F+C CP C D +EC PC C N G + C C PG++ +
Sbjct: 779 FQCRTCPSGHHLHRGRCT-DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 837
Query: 460 --INVNDC-RGQ-CQHGGTCKDLVNGYQCVCPRGFG----GRHCELERDECASSPCHSGG 511
+VN+C G C G C + + C C G+ G C L+ DEC+ G
Sbjct: 838 PCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSG 896
Query: 512 LCEDLADGFHCHCPQGF-SGPLCE--VDVDLC-EPSPCRNGA-RCYNLEGDYYCA----- 561
+C + F C CP G +GP +DVD C E P G+ RC N G Y C
Sbjct: 897 ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 956
Query: 562 ---------CPD-----DFGGKNCSVPR------------------EPCPGGACRVIDGC 589
C D ++G + C R +P PGG C+ +D C
Sbjct: 957 GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDEC 1016
Query: 590 GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT----GTYCH----------- 634
+ + CG H C + PG +F C+CD G+ G +C
Sbjct: 1017 RNRS-----------FCGAHAVCQNLPG-SFQCLCDQGYEGARDGRHCVDVNECETLQGV 1064
Query: 635 ------ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPN------------ 676
EN++ C N D + RC P G + P
Sbjct: 1065 CGAALCENVEGSFLCVCPNSPEEFDPMTG-RCVPPRTSAGTFPGSQPQAPASPVLPARPP 1123
Query: 677 ---------------------DCL-----PDPCHSRGRCYDLVNDFYCACDDGWKG---- 706
+C PD C + + C +GW
Sbjct: 1124 PPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRI 1183
Query: 707 KTCHSREFQCDAYTCSNG-GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGT 765
+ C E C +G G SGD C + ++ C G
Sbjct: 1184 QQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR-----DVDECQLFRDQVC------KSGV 1232
Query: 766 CVGSGASFSCICRDGWEGRT----CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA- 820
CV + +SC C +G+ T C N + P GG CV+ V + C C P
Sbjct: 1233 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1292
Query: 821 -GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPF 879
G R +E QS G C E+ G C + PR + C
Sbjct: 1293 DGSQRRCVSNESQSLDDNLG-VCWQEV-GADLVC----SHPRLDRQATYTECCCL----- 1341
Query: 880 PHGSSWVEDCNSCRCLD 896
+G +W DC C D
Sbjct: 1342 -YGEAWGMDCALCPAQD 1357
Score = 174 bits (442), Expect = 4e-43
Identities = 171/620 (27%), Positives = 243/620 (39%), Gaps = 112/620 (18%)
Query: 235 WMGKECKEAVCKQGCNLLHGGCTVPGEC---------RCSYGW----QGRFC---DEC-- 276
W G E E+ G + PG C C G+ QG C DEC
Sbjct: 497 WTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRR 556
Query: 277 VPYPGCVHGSCVEP---WQCNCETNW--GGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQ 330
VP P C G C ++C C + G + D++ C P + G C N P
Sbjct: 557 VP-PPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT-PGS 614
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANG-GSCHEVPSGFECHCPSGWSGPTCALD 385
+ C CP GY G +C+ + CT +P G G+C +P F C CP+G+ G C D
Sbjct: 615 FLCVCPAGYQAAPHGASCQDVDE-CTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 673
Query: 386 IDECASNPCAAG-GTCVDQVDGFECICP----EQWVGATCQLDANECEGKPCLNAFS-CK 439
+DECA P G G C + F C CP + GA CQ D +EC P + C+
Sbjct: 674 VDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYGRCE 732
Query: 440 NLIGGYYCDCIPGWK----GINCHINVNDCRGQCQ-HGGTCKDLVNGYQC-VCPRG---F 490
N G + C C G++ G C +V++C G C + +QC CP G
Sbjct: 733 NTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGHHLH 791
Query: 491 GGRHCELERDECASS--PCHSGGLCEDLADGFHCHC------PQGFSGPLCEVDVDLCEP 542
GR ++ DEC+S PC G C + F C C P G GP +V+ + E
Sbjct: 792 RGRCTDV--DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVN-ECLEG 848
Query: 543 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTA 601
C C N +G + C C + P P GA C +D C +
Sbjct: 849 DFCFPHGECLNTDGSFACTCAPGY---------RPGPRGASCLDVDECSEE------DLC 893
Query: 602 ASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLG-QPCRNGG-------TCID 653
SG+C + G+F CIC G ++ CL CR G C +
Sbjct: 894 QSGIC-------TNTDGSFECICPPGHR---AGPDLASCLDVDECRERGPALCGSQRCEN 943
Query: 654 EVDAFRCF--CPSGW----EGELCDTNP-NDCLPDPCHSRGRCYDLVNDFYC--ACDDGW 704
++RC C G+ EG D + + P+ C ++ RC + + C ACD G+
Sbjct: 944 SPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGY 1002
Query: 705 K---GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGST----CAVAKNSSCLP 757
+ G C + + C C + +F+C C G++G+ C L
Sbjct: 1003 QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1062
Query: 758 NPCVNGGTCVGSGASFSCIC 777
C C SF C+C
Sbjct: 1063 GVC-GAALCENVEGSFLCVC 1081
Score = 145 bits (365), Expect = 3e-34
Identities = 156/586 (26%), Positives = 233/586 (39%), Gaps = 121/586 (20%)
Query: 373 CPSGWS--GPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK 430
CP+G+ +C D+DECA+ G C + G+ C+CP+ ++ LD++
Sbjct: 307 CPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGFL-----LDSSRS--- 357
Query: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQC----QHGGTCKDLVNGYQ--- 483
SC I+ H+ +++ +G C + GG ++
Sbjct: 358 ------SC-----------------ISQHV-ISEAKGPCFRVLRDGGCSLPILRNITKQI 393
Query: 484 CVCPR--GFGGRHCEL--------ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 533
C C R GR C+L R+ C + P G +D + P G P
Sbjct: 394 CCCSRVGKAWGRGCQLCPPFGSEGFREICPAGP----GYHYSASDLRYNTRPLGQEPPRV 449
Query: 534 EVDVDLCEPSPCRNGA---RCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 590
+ P+ R A + LE PD G +P P
Sbjct: 450 SLSQPRTLPATSRPSAGFLPTHRLEPRPE-PRPDPRPGPELPLPSIP------------- 495
Query: 591 SDAGPGMPGTAASG--------VCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENID 638
+ GP +P + S VCGP GRC+S+P G ++C CDSGF GT C + +D
Sbjct: 496 AWTGPEIPESGPSSGMCQRNPQVCGP-GRCISRPSG-YTCACDSGFRLSPQGTRCID-VD 552
Query: 639 DC--LGQPCRNGGTCIDEVDAFRCFCPSGWE-----GELCDTNPNDCLPDPCHSRGRCYD 691
+C + PC G C + +FRC C G+ E D + +P PC GRC +
Sbjct: 553 ECRRVPPPCA-PGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC-DLGRCEN 610
Query: 692 LVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747
F C C G++ G +C + + G C + +FRC CP G++GS C
Sbjct: 611 TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSAC 670
Query: 748 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR---TCTHNTNDC--NPLPCYNGG 802
+ P G C + SF C C G+ R + ++C +P PC G
Sbjct: 671 EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPC-TYG 729
Query: 803 ICVDGVNWFRCECAPGF----AGPDCRINIDECQSSPCAYGATCVDEINGYRC-SCPPGR 857
C + F+C C GF AG +C ++DEC++ G CV+ ++C +CP G
Sbjct: 730 RCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGH 788
Query: 858 --AGPRCQEVIGFGRSCWSRGTPF-PHG-SSWVEDCNSCRCLDGRR 899
RC +V C S P PHG + E C C G R
Sbjct: 789 HLHRGRCTDV----DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 830
Score = 135 bits (339), Expect = 3e-31
Identities = 162/646 (25%), Positives = 240/646 (37%), Gaps = 138/646 (21%)
Query: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
G + E + C + T C ++ H C + C++ +C+
Sbjct: 729 GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP---GQECVNSPGSFQCR--T 783
Query: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP---WQCNCETNW-- 299
C G +L G CT EC C P HG C ++C+C +
Sbjct: 784 CPSGHHLHRGRCTDVDECSSG-------APPCGP-----HGHCTNTEGSFRCSCAPGYRA 831
Query: 300 --GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTS 353
G D+N C C G C+N + + CTC GY G +C + C+
Sbjct: 832 PSGRPGPCADVNECLEGDFCFPHGECLNTD-GSFACTCAPGYRPGPRGASCLDVDE-CSE 889
Query: 354 NPCANGGSCHEVPSGFECHCPSGW-SGPTCA--LDIDECASNPCAAGGT--CVDQVDGFE 408
G C FEC CP G +GP A LD+DEC A G+ C + +
Sbjct: 890 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYR 949
Query: 409 CI--C-PEQWVG--ATCQLDANECE--GKPCLNAFSCKNLIGGYYCD--CIPGWK---GI 456
C+ C P G TC D +EC+ G A C+N G Y C C PG++ G
Sbjct: 950 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 1008
Query: 457 NCHINVNDCRGQ--CQHGGTCKDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSG 510
C +V++CR + C C++L +QC+C +G+ GRHC ++ +EC + G
Sbjct: 1009 GCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCG 1066
Query: 511 G-LCEDLADGFHCHCPQG--------------------FSGPLCEVDVDLCEPS------ 543
LCE++ F C CP F G + P+
Sbjct: 1067 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1126
Query: 544 -----------PCRNGAR-CYNLEGDYYCACPDDFGGKNC-SVPREPCPGGACRVIDGCG 590
P +G R CY + A PD +V + C C V +G G
Sbjct: 1127 LPRRPSTPRQGPVGSGRRECY-----FDTAAPDACDNILARNVTWQEC---CCTVGEGWG 1178
Query: 591 SDAG----PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL---GQ 643
S PG +C PHGR P G+ S ++D+C Q
Sbjct: 1179 SGCRIQQCPGTETAEYQSLC-PHGRGYLAPSGDLSL-----------RRDVDECQLFRDQ 1226
Query: 644 PCRNGGTCIDEVDAFRCFCPSGWEGEL----CDTNPNDCLPDPCHSRGRCYDLVNDFYCA 699
C++G C++ + C+C +G+ C N +P GRC + V ++C
Sbjct: 1227 VCKSG-VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCT 1285
Query: 700 CD-----DGWKGKTCHSREFQCDAYTCSNGGTCY-DSGDTFRCACP 739
C+ DG + C S E Q N G C+ + G C+ P
Sbjct: 1286 CEPPLVLDG-SQRRCVSNESQS---LDDNLGVCWQEVGADLVCSHP 1327
Score = 120 bits (300), Expect = 1e-26
Identities = 192/782 (24%), Positives = 264/782 (33%), Gaps = 159/782 (20%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCE------------------------KAEHACT 352
C NGG C+ +PD RC CP ++G+ C+ A H
Sbjct: 120 CHNGGVCV--KPD--RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDD 175
Query: 353 SNPCANGGSCH-EVP--SGFECHCPSGWSGPTCALDIDECASNPCAAG------------ 397
+ A+ S H E P + H SGP D + A AA
Sbjct: 176 EHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQ 235
Query: 398 --------------GTCVDQVDGFECICPEQWV--------GATCQLDANECEGKPCLNA 435
G C ++ G EC P + GA ++C+ C
Sbjct: 236 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQ--LCSER 293
Query: 436 FSCKNLIGGYYCDCIPGWKGIN--CHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFG 491
+ C G++ +N C +V++C G+CQH G C + GY CVCP GF
Sbjct: 294 LGNSERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQH-GECANTRGGYTCVCPDGF- 350
Query: 492 GRHCELERDECASSPCHS---GGLCEDLADGFHCHCP--QGFSGPLCEVD---------V 537
+ R C S S G L DG C P + + +C
Sbjct: 351 --LLDSSRSSCISQHVISEAKGPCFRVLRDG-GCSLPILRNITKQICCCSRVGKAWGRGC 407
Query: 538 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP--CPGGACRVIDGCGSDAGP 595
LC P G R G Y D + +EP R + +
Sbjct: 408 QLCPPFG-SEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAG 466
Query: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC---- 651
+P P R +PG +TG E+ G RN C
Sbjct: 467 FLPTHRLEP--RPEPRPDPRPGPELPLPSIPAWTGPEIPES-GPSSGMCQRNPQVCGPGR 523
Query: 652 -IDEVDAFRCFCPSGW----EGELC-DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWK 705
I + C C SG+ +G C D + +P PC + GRC + F C C G++
Sbjct: 524 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFR 582
Query: 706 G----------KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK----GSTCAVAK 751
CH CD G C ++ +F C CP G++ G++C
Sbjct: 583 AGPRAAECLDVDECHRVPPPCDL------GRCENTPGSFLCVCPAGYQAAPHGASCQDVD 636
Query: 752 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDC--NPLPCYNGGICVDGVN 809
+ P C G C SF C+C G+ G C + ++C P PC G C +
Sbjct: 637 ECTQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAG 694
Query: 810 WFRCECAPGF----AGPDCRINIDECQSS--PCAYGATCVDEINGYRCSCP----PGRAG 859
F C C GF G C+ ++DEC S PC YG C + ++C CP P AG
Sbjct: 695 SFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGSFQCVCPMGFQPNTAG 752
Query: 860 PRCQEVIGFGR--SCWSRGTPFPHGSSWVEDCNSCRCLDGRR--DCSKVWCGWKPCLLAG 915
C++V +C + GS C S L R D + G PC G
Sbjct: 753 SECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 812
Query: 916 Q----PEALSAQCPLGQRCLEKAPGQCLRPPCEAWGEC--GAEEPPSTPCLPRSGHLDNN 969
+ C G R PG PC EC G P CL G
Sbjct: 813 HCTNTEGSFRCSCAPGYRAPSGRPG-----PCADVNECLEGDFCFPHGECLNTDGSFACT 867
Query: 970 CA 971
CA
Sbjct: 868 CA 869
Score = 44.7 bits (104), Expect = 6e-04
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 496 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCE----PSPCRNG 548
ELE +EC + G C + +GF C C G+ + VD++ C+ SP
Sbjct: 1494 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1553
Query: 549 ARCYNLEGDYYCACPDDF 566
ARC N +G + C C F
Sbjct: 1554 ARCLNTDGSFRCICRPGF 1571
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 336 PDG--YSGRNCE-----KAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALD 385
P+G Y+G E +AE + C NG C VP GF C C G+ +D
Sbjct: 1479 PEGGSYAGSLAEPYEELEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVD 1537
Query: 386 IDEC----ASNPCAAGGTCVDQVDGFECIC 411
I+EC A++P C++ F CIC
Sbjct: 1538 INECDEAEAASPLCVNARCLNTDGSFRCIC 1567
Score = 38.1 bits (87), Expect = 0.052
Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQW---VGATCQLDANECEGKP-----CLNA 435
L+ +EC G CV +GF C C + + + +D NEC+ C+NA
Sbjct: 1495 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1554
Query: 436 FSCKNLIGGYYCDCIPGW 453
C N G + C C PG+
Sbjct: 1555 -RCLNTDGSFRCICRPGF 1571
Score = 38.1 bits (87), Expect = 0.052
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 792 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCR---INIDECQ----SSPCAYGATCVD 844
+C L G CV F C C G+ R ++I+EC +SP A C++
Sbjct: 1499 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLN 1558
Query: 845 EINGYRCSCPPGRA 858
+RC C PG A
Sbjct: 1559 TDGSFRCICRPGFA 1572
Score = 36.6 bits (83), Expect = 0.15
Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 3/33 (9%)
Query: 795 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 827
PL C+NGG+CV RC C P FAG C+++
Sbjct: 117 PLICHNGGVCVKP---DRCLCPPDFAGKFCQLH 146
Score = 35.4 bits (80), Expect = 0.34
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 18/85 (21%)
Query: 721 CSNGGTCYDSGDTFRCACPPGWKG----------STCAVAKNSSCLPNPCVNGGTCVGSG 770
C+NG C + F C C G++ + C A+ +S L CVN C+ +
Sbjct: 1506 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL---CVNA-RCLNTD 1560
Query: 771 ASFSCICRDGWEGRTCTHNTNDCNP 795
SF CICR G+ TH + C P
Sbjct: 1561 GSFRCICRPGF---APTHQPHHCAP 1582
Score = 35.0 bits (79), Expect = 0.44
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 31/115 (26%)
Query: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----T 629
P E C ++DGC +GRCV P G F+C C G+ T
Sbjct: 1491 PYEELEAEECGILDGC------------------TNGRCVRVPEG-FTCRCFDGYRLDMT 1531
Query: 630 GTYCHENIDDC----LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680
C + I++C P C++ +FRC C G+ P+ C P
Sbjct: 1532 RMACVD-INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP---THQPHHCAP 1582
Score = 32.7 bits (73), Expect = 2.2
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 18/88 (20%)
Query: 545 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 604
C NG RC + + C C F G + R AC I+ C AAS
Sbjct: 1506 CTNG-RCVRVPEGFTCRC---FDGYRLDMTRM-----ACVDINECDE-------AEAASP 1549
Query: 605 VCGPHGRCVSQPGGNFSCICDSGFTGTY 632
+C + RC++ G +F CIC GF T+
Sbjct: 1550 LC-VNARCLNTDG-SFRCICRPGFAPTH 1575
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 14/94 (14%)
Query: 274 DECVPYPGCVHGSCV---EPWQCNC----ETNWGGLLCDKDLNYCG---SHHPCTNGGTC 323
+EC GC +G CV E + C C + + C D+N C + P C
Sbjct: 1498 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARC 1556
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+N + +RC C G++ + + H + P A
Sbjct: 1557 LNTD-GSFRCICRPGFAPTH--QPHHCAPARPRA 1587
Score = 30.8 bits (68), Expect = 8.4
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 13/59 (22%)
Query: 487 PRGFGGRHC----ELERDECASSP------CHSGGLCEDLADGFHCHCPQGFSGPLCEV 535
PRG GGR +R +P CH+GG+C C CP F+G C++
Sbjct: 90 PRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVC---VKPDRCLCPPDFAGKFCQL 145
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 221 bits (563), Expect = 3e-57
Identities = 208/679 (30%), Positives = 282/679 (41%), Gaps = 139/679 (20%)
Query: 351 CTSNPCANG-GSCHEVPSGFECHCPSGW----SGPTCALDIDEC--ASNPCAAGGTCVDQ 403
C NP G G C PSG+ C C SG+ G C +D+DEC PCA G C +
Sbjct: 549 CQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRC-IDVDECRRVPPPCAPG-RCENS 606
Query: 404 VDGFECIC-PEQWVG---ATCQLDANECEG--KPCLNAFSCKNLIGGYYCDCIPGWK--- 454
F C+C P G A C LD +EC PC + C+N G + C C G++
Sbjct: 607 PGSFRCVCGPGFRAGPRAAEC-LDVDECHRVPPPC-DLGRCENTPGSFLCVCPAGYQAAP 664
Query: 455 -GINCHINVNDCR---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSG 510
G +C +V++C G C G CK+L ++CVCP GF G CE + DECA P G
Sbjct: 665 HGASCQ-DVDECTQSPGLCGRGA-CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPCG 722
Query: 511 -GLCEDLADGFHCHCPQGFS----GPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACP 563
G C++ A FHC CP GF G C+ DVD C P PC G RC N EG + C CP
Sbjct: 723 PGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGSFQCVCP 780
Query: 564 DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSC- 622
F G C +D C + + P CV+ PG +F C
Sbjct: 781 MGFQPNTA--------GSECEDVDECENH------------LACPGQECVNSPG-SFQCR 819
Query: 623 ICDSGFTGTYCHE----NIDDCLG--QPCRNGGTCIDEVDAFRCFC------PSGWEGEL 670
C SG + H ++D+C PC G C + +FRC C PSG G
Sbjct: 820 TCPSGH---HLHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPC 876
Query: 671 CDTNPNDCLP-DPCHSRGRCYDLVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGG 725
D N +CL D C G C + F C C G++ G +C + +C G
Sbjct: 877 ADVN--ECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVD-ECSEEDLCQSG 933
Query: 726 TCYDSGDTFRCACPPGWKGSTCAVAKNSSCLP-------NPCVNGGT-CVGSGASFSCI- 776
C ++ +F C CPPG + A +SCL P + G C S S+ C+
Sbjct: 934 ICTNTDGSFECICPPGHR----AGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVR 989
Query: 777 -CRDGWEGR---TCTHNTNDCN---PLPCYNGGICVDGVNWFRCE--CAPGFA---GPDC 824
C G+ TC + ++C P C C + +RC C PG+ G C
Sbjct: 990 DCDPGYHAGPEGTCD-DVDECQEYGPEIC-GAQRCENTPGSYRCTPACDPGYQPTPGGGC 1047
Query: 825 RINIDECQS-SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+ ++DEC++ S C A C + ++C C G G R GR C
Sbjct: 1048 Q-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR------DGRHC----------- 1089
Query: 884 SWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPC 943
D N C L G CG L + CP + G+C+ P
Sbjct: 1090 ---VDVNECETLQG-------VCG--AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRT 1137
Query: 944 EAWGECGAE-EPPSTPCLP 961
A G++ + P++P LP
Sbjct: 1138 SAGTFPGSQPQAPASPVLP 1156
Score = 176 bits (445), Expect = 2e-43
Identities = 199/797 (24%), Positives = 277/797 (34%), Gaps = 191/797 (23%)
Query: 249 CNLLHGGC-TVPGE--CRCSYGWQ----GRFC---DECVPYPG-CVHGSCVE---PWQCN 294
C+L G C PG C C G+Q G C DEC PG C G+C ++C
Sbjct: 640 CDL--GRCENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCV 697
Query: 295 CETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRN----CEKAEHA 350
C + G C++D++ C P G C N + C CP G+ R C+ +
Sbjct: 698 CPAGFRGSACEEDVDECAQEPPPCGPGRCDNTA-GSFHCACPAGFRSRGPGAPCQDVDEC 756
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGW----SGPTCALDIDECASNPCAAGGTCVDQVDG 406
S P G C F+C CP G+ +G C D+DEC ++ G CV+
Sbjct: 757 ARSPPPCTYGRCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGS 815
Query: 407 FEC-ICPE--QWVGATCQLDANECEG--KPCLNAFSCKNLIGGYYCDCIPGWKGINCH-- 459
F+C CP C D +EC PC C N G + C C PG++ +
Sbjct: 816 FQCRTCPSGHHLHRGRCT-DVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPG 874
Query: 460 --INVNDC-RGQ-CQHGGTCKDLVNGYQCVCPRGFG----GRHCELERDECASSPCHSGG 511
+VN+C G C G C + + C C G+ G C L+ DEC+ G
Sbjct: 875 PCADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRPGPRGASC-LDVDECSEEDLCQSG 933
Query: 512 LCEDLADGFHCHCPQGF-SGPLCE--VDVDLC-EPSPCRNGA-RCYNLEGDYYCA----- 561
+C + F C CP G +GP +DVD C E P G+ RC N G Y C
Sbjct: 934 ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCDP 993
Query: 562 ---------CPD-----DFGGKNCSVPR------------------EPCPGGACRVIDGC 589
C D ++G + C R +P PGG C+ +D C
Sbjct: 994 GYHAGPEGTCDDVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQDVDEC 1053
Query: 590 GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFT----GTYCH----------- 634
+ + CG H C + PG +F C+CD G+ G +C
Sbjct: 1054 RNRS-----------FCGAHAVCQNLPG-SFQCLCDQGYEGARDGRHCVDVNECETLQGV 1101
Query: 635 ------ENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPN------------ 676
EN++ C N D + RC P G + P
Sbjct: 1102 CGAALCENVEGSFLCVCPNSPEEFDPMTG-RCVPPRTSAGTFPGSQPQAPASPVLPARPP 1160
Query: 677 ---------------------DCL-----PDPCHSRGRCYDLVNDFYCACDDGWKG---- 706
+C PD C + + C +GW
Sbjct: 1161 PPPLPRRPSTPRQGPVGSGRRECYFDTAAPDACDNILARNVTWQECCCTVGEGWGSGCRI 1220
Query: 707 KTCHSREFQCDAYTCSNG-GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGT 765
+ C E C +G G SGD C + ++ C G
Sbjct: 1221 QQCPGTETAEYQSLCPHGRGYLAPSGDLSLRR-----DVDECQLFRDQVC------KSGV 1269
Query: 766 CVGSGASFSCICRDGWEGRT----CTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFA- 820
CV + +SC C +G+ T C N + P GG CV+ V + C C P
Sbjct: 1270 CVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCTCEPPLVL 1329
Query: 821 -GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPF 879
G R +E QS G C E+ G C + PR + C
Sbjct: 1330 DGSQRRCVSNESQSLDDNLG-VCWQEV-GADLVC----SHPRLDRQATYTECCCL----- 1378
Query: 880 PHGSSWVEDCNSCRCLD 896
+G +W DC C D
Sbjct: 1379 -YGEAWGMDCALCPAQD 1394
Score = 174 bits (442), Expect = 4e-43
Identities = 171/620 (27%), Positives = 243/620 (39%), Gaps = 112/620 (18%)
Query: 235 WMGKECKEAVCKQGCNLLHGGCTVPGEC---------RCSYGW----QGRFC---DEC-- 276
W G E E+ G + PG C C G+ QG C DEC
Sbjct: 534 WTGPEIPESGPSSGMCQRNPQVCGPGRCISRPSGYTCACDSGFRLSPQGTRCIDVDECRR 593
Query: 277 VPYPGCVHGSCVEP---WQCNCETNW--GGLLCD-KDLNYCGSHHPCTNGGTCINAEPDQ 330
VP P C G C ++C C + G + D++ C P + G C N P
Sbjct: 594 VP-PPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENT-PGS 651
Query: 331 YRCTCPDGYS----GRNCEKAEHACTSNPCANG-GSCHEVPSGFECHCPSGWSGPTCALD 385
+ C CP GY G +C+ + CT +P G G+C +P F C CP+G+ G C D
Sbjct: 652 FLCVCPAGYQAAPHGASCQDVDE-CTQSPGLCGRGACKNLPGSFRCVCPAGFRGSACEED 710
Query: 386 IDECASNPCAAG-GTCVDQVDGFECICP----EQWVGATCQLDANECEGKPCLNAFS-CK 439
+DECA P G G C + F C CP + GA CQ D +EC P + C+
Sbjct: 711 VDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYGRCE 769
Query: 440 NLIGGYYCDCIPGWK----GINCHINVNDCRGQCQ-HGGTCKDLVNGYQC-VCPRG---F 490
N G + C C G++ G C +V++C G C + +QC CP G
Sbjct: 770 NTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGHHLH 828
Query: 491 GGRHCELERDECASS--PCHSGGLCEDLADGFHCHC------PQGFSGPLCEVDVDLCEP 542
GR ++ DEC+S PC G C + F C C P G GP +V+ + E
Sbjct: 829 RGRCTDV--DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVN-ECLEG 885
Query: 543 SPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGA-CRVIDGCGSDAGPGMPGTA 601
C C N +G + C C + P P GA C +D C +
Sbjct: 886 DFCFPHGECLNTDGSFACTCAPGY---------RPGPRGASCLDVDECSEE------DLC 930
Query: 602 ASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLG-QPCRNGG-------TCID 653
SG+C + G+F CIC G ++ CL CR G C +
Sbjct: 931 QSGIC-------TNTDGSFECICPPGHR---AGPDLASCLDVDECRERGPALCGSQRCEN 980
Query: 654 EVDAFRCF--CPSGW----EGELCDTNP-NDCLPDPCHSRGRCYDLVNDFYC--ACDDGW 704
++RC C G+ EG D + + P+ C ++ RC + + C ACD G+
Sbjct: 981 SPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQ-RCENTPGSYRCTPACDPGY 1039
Query: 705 K---GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGST----CAVAKNSSCLP 757
+ G C + + C C + +F+C C G++G+ C L
Sbjct: 1040 QPTPGGGCQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHCVDVNECETLQ 1099
Query: 758 NPCVNGGTCVGSGASFSCIC 777
C C SF C+C
Sbjct: 1100 GVC-GAALCENVEGSFLCVC 1118
Score = 145 bits (365), Expect = 3e-34
Identities = 156/586 (26%), Positives = 233/586 (39%), Gaps = 121/586 (20%)
Query: 373 CPSGWS--GPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK 430
CP+G+ +C D+DECA+ G C + G+ C+CP+ ++ LD++
Sbjct: 344 CPTGFERVNGSCE-DVDECATGGRCQHGECANTRGGYTCVCPDGFL-----LDSSRS--- 394
Query: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQC----QHGGTCKDLVNGYQ--- 483
SC I+ H+ +++ +G C + GG ++
Sbjct: 395 ------SC-----------------ISQHV-ISEAKGPCFRVLRDGGCSLPILRNITKQI 430
Query: 484 CVCPR--GFGGRHCEL--------ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLC 533
C C R GR C+L R+ C + P G +D + P G P
Sbjct: 431 CCCSRVGKAWGRGCQLCPPFGSEGFREICPAGP----GYHYSASDLRYNTRPLGQEPPRV 486
Query: 534 EVDVDLCEPSPCRNGA---RCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCG 590
+ P+ R A + LE PD G +P P
Sbjct: 487 SLSQPRTLPATSRPSAGFLPTHRLEPRPE-PRPDPRPGPELPLPSIP------------- 532
Query: 591 SDAGPGMPGTAASG--------VCGPHGRCVSQPGGNFSCICDSGF----TGTYCHENID 638
+ GP +P + S VCGP GRC+S+P G ++C CDSGF GT C + +D
Sbjct: 533 AWTGPEIPESGPSSGMCQRNPQVCGP-GRCISRPSG-YTCACDSGFRLSPQGTRCID-VD 589
Query: 639 DC--LGQPCRNGGTCIDEVDAFRCFCPSGWE-----GELCDTNPNDCLPDPCHSRGRCYD 691
+C + PC G C + +FRC C G+ E D + +P PC GRC +
Sbjct: 590 ECRRVPPPCA-PGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPC-DLGRCEN 647
Query: 692 LVNDFYCACDDGWK----GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC 747
F C C G++ G +C + + G C + +FRC CP G++GS C
Sbjct: 648 TPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRGSAC 707
Query: 748 AVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR---TCTHNTNDC--NPLPCYNGG 802
+ P G C + SF C C G+ R + ++C +P PC G
Sbjct: 708 EEDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPC-TYG 766
Query: 803 ICVDGVNWFRCECAPGF----AGPDCRINIDECQSSPCAYGATCVDEINGYRC-SCPPGR 857
C + F+C C GF AG +C ++DEC++ G CV+ ++C +CP G
Sbjct: 767 RCENTEGSFQCVCPMGFQPNTAGSECE-DVDECENHLACPGQECVNSPGSFQCRTCPSGH 825
Query: 858 --AGPRCQEVIGFGRSCWSRGTPF-PHG-SSWVEDCNSCRCLDGRR 899
RC +V C S P PHG + E C C G R
Sbjct: 826 HLHRGRCTDV----DECSSGAPPCGPHGHCTNTEGSFRCSCAPGYR 867
Score = 135 bits (339), Expect = 3e-31
Identities = 162/646 (25%), Positives = 240/646 (37%), Gaps = 138/646 (21%)
Query: 185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAV 244
G + E + C + T C ++ H C + C++ +C+
Sbjct: 766 GRCENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACP---GQECVNSPGSFQCR--T 820
Query: 245 CKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEP---WQCNCETNW-- 299
C G +L G CT EC C P HG C ++C+C +
Sbjct: 821 CPSGHHLHRGRCTDVDECSSG-------APPCGP-----HGHCTNTEGSFRCSCAPGYRA 868
Query: 300 --GGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS----GRNCEKAEHACTS 353
G D+N C C G C+N + + CTC GY G +C + C+
Sbjct: 869 PSGRPGPCADVNECLEGDFCFPHGECLNTD-GSFACTCAPGYRPGPRGASCLDVDE-CSE 926
Query: 354 NPCANGGSCHEVPSGFECHCPSGW-SGPTCA--LDIDECASNPCAAGGT--CVDQVDGFE 408
G C FEC CP G +GP A LD+DEC A G+ C + +
Sbjct: 927 EDLCQSGICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYR 986
Query: 409 CI--C-PEQWVG--ATCQLDANECE--GKPCLNAFSCKNLIGGYYCD--CIPGWK---GI 456
C+ C P G TC D +EC+ G A C+N G Y C C PG++ G
Sbjct: 987 CVRDCDPGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGG 1045
Query: 457 NCHINVNDCRGQ--CQHGGTCKDLVNGYQCVCPRGF----GGRHCELERDECASSPCHSG 510
C +V++CR + C C++L +QC+C +G+ GRHC ++ +EC + G
Sbjct: 1046 GCQ-DVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRHC-VDVNECETLQGVCG 1103
Query: 511 G-LCEDLADGFHCHCPQG--------------------FSGPLCEVDVDLCEPS------ 543
LCE++ F C CP F G + P+
Sbjct: 1104 AALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPP 1163
Query: 544 -----------PCRNGAR-CYNLEGDYYCACPDDFGGKNC-SVPREPCPGGACRVIDGCG 590
P +G R CY + A PD +V + C C V +G G
Sbjct: 1164 LPRRPSTPRQGPVGSGRRECY-----FDTAAPDACDNILARNVTWQEC---CCTVGEGWG 1215
Query: 591 SDAG----PGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL---GQ 643
S PG +C PHGR P G+ S ++D+C Q
Sbjct: 1216 SGCRIQQCPGTETAEYQSLC-PHGRGYLAPSGDLSL-----------RRDVDECQLFRDQ 1263
Query: 644 PCRNGGTCIDEVDAFRCFCPSGWEGEL----CDTNPNDCLPDPCHSRGRCYDLVNDFYCA 699
C++G C++ + C+C +G+ C N +P GRC + V ++C
Sbjct: 1264 VCKSG-VCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPACEGGRCVNTVGSYHCT 1322
Query: 700 CD-----DGWKGKTCHSREFQCDAYTCSNGGTCY-DSGDTFRCACP 739
C+ DG + C S E Q N G C+ + G C+ P
Sbjct: 1323 CEPPLVLDG-SQRRCVSNESQS---LDDNLGVCWQEVGADLVCSHP 1364
Score = 120 bits (300), Expect = 1e-26
Identities = 192/782 (24%), Positives = 264/782 (33%), Gaps = 159/782 (20%)
Query: 317 CTNGGTCINAEPDQYRCTCPDGYSGRNCE------------------------KAEHACT 352
C NGG C+ +PD RC CP ++G+ C+ A H
Sbjct: 157 CHNGGVCV--KPD--RCLCPPDFAGKFCQLHSSGARPPAPAVPGLTRSVYTMPLANHRDD 212
Query: 353 SNPCANGGSCH-EVP--SGFECHCPSGWSGPTCALDIDECASNPCAAG------------ 397
+ A+ S H E P + H SGP D + A AA
Sbjct: 213 EHGVASMVSVHVEHPQEASVVVHQVERVSGPWEEADAEAVARAEAAARAEAAAPYTVLAQ 272
Query: 398 --------------GTCVDQVDGFECICPEQWV--------GATCQLDANECEGKPCLNA 435
G C ++ G EC P + GA ++C+ C
Sbjct: 273 SAPREDGYSDASGFGYCFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQ--LCSER 330
Query: 436 FSCKNLIGGYYCDCIPGWKGIN--CHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFG 491
+ C G++ +N C +V++C G+CQH G C + GY CVCP GF
Sbjct: 331 LGNSERVSAPDGPCPTGFERVNGSCE-DVDECATGGRCQH-GECANTRGGYTCVCPDGF- 387
Query: 492 GRHCELERDECASSPCHS---GGLCEDLADGFHCHCP--QGFSGPLCEVD---------V 537
+ R C S S G L DG C P + + +C
Sbjct: 388 --LLDSSRSSCISQHVISEAKGPCFRVLRDG-GCSLPILRNITKQICCCSRVGKAWGRGC 444
Query: 538 DLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP--CPGGACRVIDGCGSDAGP 595
LC P G R G Y D + +EP R + +
Sbjct: 445 QLCPPFG-SEGFREICPAGPGYHYSASDLRYNTRPLGQEPPRVSLSQPRTLPATSRPSAG 503
Query: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC---- 651
+P P R +PG +TG E+ G RN C
Sbjct: 504 FLPTHRLEP--RPEPRPDPRPGPELPLPSIPAWTGPEIPES-GPSSGMCQRNPQVCGPGR 560
Query: 652 -IDEVDAFRCFCPSGW----EGELC-DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWK 705
I + C C SG+ +G C D + +P PC + GRC + F C C G++
Sbjct: 561 CISRPSGYTCACDSGFRLSPQGTRCIDVDECRRVPPPC-APGRCENSPGSFRCVCGPGFR 619
Query: 706 G----------KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK----GSTCAVAK 751
CH CD G C ++ +F C CP G++ G++C
Sbjct: 620 AGPRAAECLDVDECHRVPPPCDL------GRCENTPGSFLCVCPAGYQAAPHGASCQDVD 673
Query: 752 NSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDC--NPLPCYNGGICVDGVN 809
+ P C G C SF C+C G+ G C + ++C P PC G C +
Sbjct: 674 ECTQSPGLC-GRGACKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAG 731
Query: 810 WFRCECAPGF----AGPDCRINIDECQSS--PCAYGATCVDEINGYRCSCP----PGRAG 859
F C C GF G C+ ++DEC S PC YG C + ++C CP P AG
Sbjct: 732 SFHCACPAGFRSRGPGAPCQ-DVDECARSPPPCTYG-RCENTEGSFQCVCPMGFQPNTAG 789
Query: 860 PRCQEVIGFGR--SCWSRGTPFPHGSSWVEDCNSCRCLDGRR--DCSKVWCGWKPCLLAG 915
C++V +C + GS C S L R D + G PC G
Sbjct: 790 SECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSGAPPCGPHG 849
Query: 916 Q----PEALSAQCPLGQRCLEKAPGQCLRPPCEAWGEC--GAEEPPSTPCLPRSGHLDNN 969
+ C G R PG PC EC G P CL G
Sbjct: 850 HCTNTEGSFRCSCAPGYRAPSGRPG-----PCADVNECLEGDFCFPHGECLNTDGSFACT 904
Query: 970 CA 971
CA
Sbjct: 905 CA 906
Score = 44.7 bits (104), Expect = 6e-04
Identities = 25/78 (32%), Positives = 36/78 (46%), Gaps = 7/78 (8%)
Query: 496 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE---VDVDLCE----PSPCRNG 548
ELE +EC + G C + +GF C C G+ + VD++ C+ SP
Sbjct: 1531 ELEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVN 1590
Query: 549 ARCYNLEGDYYCACPDDF 566
ARC N +G + C C F
Sbjct: 1591 ARCLNTDGSFRCICRPGF 1608
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/90 (32%), Positives = 40/90 (44%), Gaps = 15/90 (16%)
Query: 336 PDG--YSGRNCE-----KAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALD 385
P+G Y+G E +AE + C NG C VP GF C C G+ +D
Sbjct: 1516 PEGGSYAGSLAEPYEELEAEECGILDGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVD 1574
Query: 386 IDEC----ASNPCAAGGTCVDQVDGFECIC 411
I+EC A++P C++ F CIC
Sbjct: 1575 INECDEAEAASPLCVNARCLNTDGSFRCIC 1604
Score = 38.1 bits (87), Expect = 0.052
Identities = 24/78 (30%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 384 LDIDECASNPCAAGGTCVDQVDGFECICPEQW---VGATCQLDANECEGKP-----CLNA 435
L+ +EC G CV +GF C C + + + +D NEC+ C+NA
Sbjct: 1532 LEAEECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNA 1591
Query: 436 FSCKNLIGGYYCDCIPGW 453
C N G + C C PG+
Sbjct: 1592 -RCLNTDGSFRCICRPGF 1608
Score = 38.1 bits (87), Expect = 0.052
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 7/74 (9%)
Query: 792 DCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCR---INIDECQ----SSPCAYGATCVD 844
+C L G CV F C C G+ R ++I+EC +SP A C++
Sbjct: 1536 ECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPLCVNARCLN 1595
Query: 845 EINGYRCSCPPGRA 858
+RC C PG A
Sbjct: 1596 TDGSFRCICRPGFA 1609
Score = 36.6 bits (83), Expect = 0.15
Identities = 16/33 (48%), Positives = 21/33 (63%), Gaps = 3/33 (9%)
Query: 795 PLPCYNGGICVDGVNWFRCECAPGFAGPDCRIN 827
PL C+NGG+CV RC C P FAG C+++
Sbjct: 154 PLICHNGGVCVKP---DRCLCPPDFAGKFCQLH 183
Score = 35.4 bits (80), Expect = 0.34
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 18/85 (21%)
Query: 721 CSNGGTCYDSGDTFRCACPPGWKG----------STCAVAKNSSCLPNPCVNGGTCVGSG 770
C+NG C + F C C G++ + C A+ +S L CVN C+ +
Sbjct: 1543 CTNG-RCVRVPEGFTCRCFDGYRLDMTRMACVDINECDEAEAASPL---CVNA-RCLNTD 1597
Query: 771 ASFSCICRDGWEGRTCTHNTNDCNP 795
SF CICR G+ TH + C P
Sbjct: 1598 GSFRCICRPGF---APTHQPHHCAP 1619
Score = 35.0 bits (79), Expect = 0.44
Identities = 30/115 (26%), Positives = 43/115 (37%), Gaps = 31/115 (26%)
Query: 574 PREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF----T 629
P E C ++DGC +GRCV P G F+C C G+ T
Sbjct: 1528 PYEELEAEECGILDGC------------------TNGRCVRVPEG-FTCRCFDGYRLDMT 1568
Query: 630 GTYCHENIDDC----LGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLP 680
C + I++C P C++ +FRC C G+ P+ C P
Sbjct: 1569 RMACVD-INECDEAEAASPLCVNARCLNTDGSFRCICRPGFAP---THQPHHCAP 1619
Score = 32.7 bits (73), Expect = 2.2
Identities = 28/88 (31%), Positives = 38/88 (43%), Gaps = 18/88 (20%)
Query: 545 CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASG 604
C NG RC + + C C F G + R AC I+ C AAS
Sbjct: 1543 CTNG-RCVRVPEGFTCRC---FDGYRLDMTRM-----ACVDINECDE-------AEAASP 1586
Query: 605 VCGPHGRCVSQPGGNFSCICDSGFTGTY 632
+C + RC++ G +F CIC GF T+
Sbjct: 1587 LC-VNARCLNTDG-SFRCICRPGFAPTH 1612
Score = 31.2 bits (69), Expect = 6.4
Identities = 24/94 (25%), Positives = 39/94 (41%), Gaps = 14/94 (14%)
Query: 274 DECVPYPGCVHGSCV---EPWQCNC----ETNWGGLLCDKDLNYCG---SHHPCTNGGTC 323
+EC GC +G CV E + C C + + C D+N C + P C
Sbjct: 1535 EECGILDGCTNGRCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARC 1593
Query: 324 INAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCA 357
+N + +RC C G++ + + H + P A
Sbjct: 1594 LNTD-GSFRCICRPGFAPTH--QPHHCAPARPRA 1624
Score = 30.8 bits (68), Expect = 8.4
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 13/59 (22%)
Query: 487 PRGFGGRHC----ELERDECASSP------CHSGGLCEDLADGFHCHCPQGFSGPLCEV 535
PRG GGR +R +P CH+GG+C C CP F+G C++
Sbjct: 127 PRGPGGRGLLRRRPPQRAPAGKAPVLCPLICHNGGVC---VKPDRCLCPPDFAGKFCQL 182
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 217 bits (552), Expect = 6e-56
Identities = 149/493 (30%), Positives = 203/493 (41%), Gaps = 80/493 (16%)
Query: 14 LLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRV 73
++L +++ RP G FELQ+ + G + C C + RV
Sbjct: 14 VILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSA-----------RLPCRLFFRV 62
Query: 74 CLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIP 133
CLK ++ PC+ G A G + P A D GL+ +P
Sbjct: 63 CLKPGLSEEAAESPCALG--AALSARGPVYTEQPGAPAPDLPLP---------DGLLQVP 111
Query: 134 FQFAWPRSFTLIVEAWDWDNDTTPNEEL----------LIERVSHAGMINPEDRWKSLHF 183
F+ AWP +F+ I+E W EEL L+ RV+ + W
Sbjct: 112 FRDAWPGTFSFIIETW--------REELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQ 163
Query: 184 SGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 243
L R RC+ C + CRPR+ C G + C + EC+
Sbjct: 164 RAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAP 217
Query: 244 -VCKQGCNLLHGGCTVPGECRCSYGWQGRFC------DEC--------------VPYPG- 281
VC+ GC+ HG C PGECRC GW G C C VP PG
Sbjct: 218 LVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
Query: 282 -----CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCIN-AEPDQ- 330
C +G SC E ++C C + GL C+ C PC NGG C+ A+PD
Sbjct: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPDSA 336
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
Y C CP G+ G NCEK C+ PC NGG C ++ C C +G++GP C D+D+CA
Sbjct: 337 YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA 396
Query: 391 SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCI 450
CA GGTCV+ C C + G C+ A+ C +PC + C G C C
Sbjct: 397 GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACA 456
Query: 451 PGWKGINCHINVN 463
PG+ G C V+
Sbjct: 457 PGYMGARCEFPVH 469
Score = 173 bits (439), Expect = 8e-43
Identities = 103/307 (33%), Positives = 128/307 (41%), Gaps = 42/307 (13%)
Query: 577 PCPGGACRVI---DGCGSDAGPGM------------PGTAASGVCGPHGRCVSQPGGNFS 621
P G AC + S GPG+ P +G HG C QPG
Sbjct: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG---E 236
Query: 622 CICDSGFTGTYCHENID--DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 679
C C G+TG C + CL + T C P P C
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-------GCLVPG----------PGPCD 279
Query: 680 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD---TFRC 736
+PC + G C + F C C G+ G C C C NGG C D + C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 737 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 796
CPPG++GS C + C PC NGG C+ G + C CR G+ G C H+ +DC
Sbjct: 340 HCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 797 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 856
C NGG CV+G RC CA GF G DCR D C + PCA+G C +G C+C PG
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 857 RAGPRCQ 863
G RC+
Sbjct: 459 YMGARCE 465
Score = 167 bits (422), Expect = 7e-41
Identities = 90/271 (33%), Positives = 113/271 (41%), Gaps = 40/271 (14%)
Query: 342 RNCEKAEHACTSNPCANGGSCHEVPSGF-----ECHCPSGWSGPTCALDIDE-------- 388
R C E C + G E GF EC C GW+GP C + +
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPE--HGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRG 262
Query: 389 ---------------CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCL 433
C NPCA GG+C + FEC CP + G C++ C PC
Sbjct: 263 PSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCF 322
Query: 434 NAFSCKNLIGG------YYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVC 486
N C +GG Y C C PG++G NC V+ C Q C++GG C DL + +C C
Sbjct: 323 NGGLC---VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRC 379
Query: 487 PRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCR 546
GF G CE + D+CA C +GG C + C C GF G C D C PC
Sbjct: 380 RAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
Query: 547 NGARCYNLEGDYYCACPDDFGGKNCSVPREP 577
+G RCY CAC + G C P P
Sbjct: 440 HGGRCYAHFSGLVCACAPGYMGARCEFPVHP 470
Score = 146 bits (368), Expect = 1e-34
Identities = 83/245 (33%), Positives = 110/245 (44%), Gaps = 30/245 (12%)
Query: 660 CFCPSGWEGELCDT--NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 717
C C GW G LC + + CL S LV CD
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------PGPCD 279
Query: 718 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG---ASFS 774
C+NGG+C ++ +F C CP G+ G C V+ +C PC NGG CVG +++
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVS-GVTCADGPCFNGGLCVGGADPDSAYI 338
Query: 775 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 834
C C G++G C + C+ PC NGG+C+D + RC C GFAGP C ++D+C
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 835 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSC 892
CA G TCV+ +RCSC G G C+E R C G + H S V C
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV-----C 453
Query: 893 RCLDG 897
C G
Sbjct: 454 ACAPG 458
Score = 122 bits (307), Expect = 2e-27
Identities = 85/278 (30%), Positives = 109/278 (39%), Gaps = 69/278 (24%)
Query: 707 KTCHSREFQCDA-YTCSNG-----GTCYDSGDTFRCACPPGWKGSTCAV-AKNSSCLP-- 757
+ C E +C+A C G G C G+ C C GW G C V SSCL
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPR 261
Query: 758 -------------------NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 798
NPC NGG+C + SF C C G+ G C + C PC
Sbjct: 262 GPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
Query: 799 YNGGICVDGVN---WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 855
+NGG+CV G + + C C PGF G +C +D C PC G C+D + RC C
Sbjct: 322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRA 381
Query: 856 GRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLL 913
G AGPRC+ + GR+C + GT G + + C C G
Sbjct: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGA-----HRCSCALGFG-------------- 422
Query: 914 AGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 951
G+ C E+A C PC G C A
Sbjct: 423 -------------GRDCRERAD-PCAARPCAHGGRCYA 446
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 23/147 (15%)
Query: 837 AYGATCVDEINGYRCS------CPPGRAGPRCQEVIGFGRSCWS-----RGTPFPHGSSW 885
+Y A C G C+ P R GP + C + G HG +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG--F 230
Query: 886 VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR--CLEKAPGQCLRPPC 943
E CRCL+G W G + LS + P CL PG C PC
Sbjct: 231 CEQPGECRCLEG-------WTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
Query: 944 EAWGECGAEEPPSTPCLPRSGHLDNNC 970
G C +E P S C G C
Sbjct: 284 ANGGSC-SETPRSFECTCPRGFYGLRC 309
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 217 bits (552), Expect = 6e-56
Identities = 149/493 (30%), Positives = 203/493 (41%), Gaps = 80/493 (16%)
Query: 14 LLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRV 73
++L +++ RP G FELQ+ + G + C C + RV
Sbjct: 14 VILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSA-----------RLPCRLFFRV 62
Query: 74 CLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIP 133
CLK ++ PC+ G A G + P A D GL+ +P
Sbjct: 63 CLKPGLSEEAAESPCALG--AALSARGPVYTEQPGAPAPDLPLP---------DGLLQVP 111
Query: 134 FQFAWPRSFTLIVEAWDWDNDTTPNEEL----------LIERVSHAGMINPEDRWKSLHF 183
F+ AWP +F+ I+E W EEL L+ RV+ + W
Sbjct: 112 FRDAWPGTFSFIIETW--------REELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQ 163
Query: 184 SGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA 243
L R RC+ C + CRPR+ C G + C + EC+
Sbjct: 164 RAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAP 217
Query: 244 -VCKQGCNLLHGGCTVPGECRCSYGWQGRFC------DEC--------------VPYPG- 281
VC+ GC+ HG C PGECRC GW G C C VP PG
Sbjct: 218 LVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
Query: 282 -----CVHG-SCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCIN-AEPDQ- 330
C +G SC E ++C C + GL C+ C PC NGG C+ A+PD
Sbjct: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPDSA 336
Query: 331 YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECA 390
Y C CP G+ G NCEK C+ PC NGG C ++ C C +G++GP C D+D+CA
Sbjct: 337 YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA 396
Query: 391 SNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCI 450
CA GGTCV+ C C + G C+ A+ C +PC + C G C C
Sbjct: 397 GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACA 456
Query: 451 PGWKGINCHINVN 463
PG+ G C V+
Sbjct: 457 PGYMGARCEFPVH 469
Score = 173 bits (439), Expect = 8e-43
Identities = 103/307 (33%), Positives = 128/307 (41%), Gaps = 42/307 (13%)
Query: 577 PCPGGACRVI---DGCGSDAGPGM------------PGTAASGVCGPHGRCVSQPGGNFS 621
P G AC + S GPG+ P +G HG C QPG
Sbjct: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG---E 236
Query: 622 CICDSGFTGTYCHENID--DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 679
C C G+TG C + CL + T C P P C
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-------GCLVPG----------PGPCD 279
Query: 680 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD---TFRC 736
+PC + G C + F C C G+ G C C C NGG C D + C
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
Query: 737 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 796
CPPG++GS C + C PC NGG C+ G + C CR G+ G C H+ +DC
Sbjct: 340 HCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 797 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 856
C NGG CV+G RC CA GF G DCR D C + PCA+G C +G C+C PG
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
Query: 857 RAGPRCQ 863
G RC+
Sbjct: 459 YMGARCE 465
Score = 167 bits (422), Expect = 7e-41
Identities = 90/271 (33%), Positives = 113/271 (41%), Gaps = 40/271 (14%)
Query: 342 RNCEKAEHACTSNPCANGGSCHEVPSGF-----ECHCPSGWSGPTCALDIDE-------- 388
R C E C + G E GF EC C GW+GP C + +
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPE--HGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRG 262
Query: 389 ---------------CASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCL 433
C NPCA GG+C + FEC CP + G C++ C PC
Sbjct: 263 PSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCF 322
Query: 434 NAFSCKNLIGG------YYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVC 486
N C +GG Y C C PG++G NC V+ C Q C++GG C DL + +C C
Sbjct: 323 NGGLC---VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRC 379
Query: 487 PRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCR 546
GF G CE + D+CA C +GG C + C C GF G C D C PC
Sbjct: 380 RAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
Query: 547 NGARCYNLEGDYYCACPDDFGGKNCSVPREP 577
+G RCY CAC + G C P P
Sbjct: 440 HGGRCYAHFSGLVCACAPGYMGARCEFPVHP 470
Score = 146 bits (368), Expect = 1e-34
Identities = 83/245 (33%), Positives = 110/245 (44%), Gaps = 30/245 (12%)
Query: 660 CFCPSGWEGELCDT--NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 717
C C GW G LC + + CL S LV CD
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------PGPCD 279
Query: 718 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG---ASFS 774
C+NGG+C ++ +F C CP G+ G C V+ +C PC NGG CVG +++
Sbjct: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVS-GVTCADGPCFNGGLCVGGADPDSAYI 338
Query: 775 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 834
C C G++G C + C+ PC NGG+C+D + RC C GFAGP C ++D+C
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
Query: 835 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSC 892
CA G TCV+ +RCSC G G C+E R C G + H S V C
Sbjct: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV-----C 453
Query: 893 RCLDG 897
C G
Sbjct: 454 ACAPG 458
Score = 122 bits (307), Expect = 2e-27
Identities = 85/278 (30%), Positives = 109/278 (39%), Gaps = 69/278 (24%)
Query: 707 KTCHSREFQCDA-YTCSNG-----GTCYDSGDTFRCACPPGWKGSTCAV-AKNSSCLP-- 757
+ C E +C+A C G G C G+ C C GW G C V SSCL
Sbjct: 205 RPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPR 261
Query: 758 -------------------NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 798
NPC NGG+C + SF C C G+ G C + C PC
Sbjct: 262 GPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
Query: 799 YNGGICVDGVN---WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 855
+NGG+CV G + + C C PGF G +C +D C PC G C+D + RC C
Sbjct: 322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRA 381
Query: 856 GRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLL 913
G AGPRC+ + GR+C + GT G + + C C G
Sbjct: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGA-----HRCSCALGFG-------------- 422
Query: 914 AGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 951
G+ C E+A C PC G C A
Sbjct: 423 -------------GRDCRERAD-PCAARPCAHGGRCYA 446
Score = 36.6 bits (83), Expect = 0.15
Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 23/147 (15%)
Query: 837 AYGATCVDEINGYRCS------CPPGRAGPRCQEVIGFGRSCWS-----RGTPFPHGSSW 885
+Y A C G C+ P R GP + C + G HG +
Sbjct: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG--F 230
Query: 886 VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR--CLEKAPGQCLRPPC 943
E CRCL+G W G + LS + P CL PG C PC
Sbjct: 231 CEQPGECRCLEG-------WTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
Query: 944 EAWGECGAEEPPSTPCLPRSGHLDNNC 970
G C +E P S C G C
Sbjct: 284 ANGGSC-SETPRSFECTCPRGFYGLRC 309
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 215 bits (547), Expect = 2e-55
Identities = 228/783 (29%), Positives = 305/783 (38%), Gaps = 157/783 (20%)
Query: 211 CRPRNDFFGHYTCDQYGNK---ACMDGW-----MGKECKEA-VCKQGCNLLHGG-CTVPG 260
CR D G TC C G+ + K C + C + L GG CT
Sbjct: 1032 CRISPDLCGQGTCVNTPGSFECECFPGYESGFMLMKNCMDVDECARDPLLCRGGTCTNTD 1091
Query: 261 ---ECRCSYGWQ----GRFC---DECVPYPG-CVHGSCVE---PWQCNCETNWGGLLCDK 306
+C+C G + G C DEC G C HG CV +QC+C G
Sbjct: 1092 GSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCHA---GFQSTP 1148
Query: 307 DLNYCGSHHPCT--NGGT---CINAEPDQYRCTCPDGYS----GRNCEKAEHACTSNP-C 356
D C + C NGG CIN E YRC+C GYS GR C + C NP
Sbjct: 1149 DRQGCVDINECRVQNGGCDVHCINTE-GSYRCSCGQGYSLMPDGRACADVDE-CEENPRV 1206
Query: 357 ANGGSCHEVPSGFECHCPSGWSGP----TCALDIDECASNP-CAAGGTCVDQVDGFECIC 411
+ G C +P G C C G+ TC +D+DEC NP G C + F C C
Sbjct: 1207 CDQGHCTNMPGGHRCLCYDGFMATPDMRTC-VDVDECDLNPHICLHGDCENTKGSFVCHC 1265
Query: 412 PEQWV---GATCQLDANECE--GKPCLNAFSCKNLIGGYYCDCIPGW--KGINCHINVND 464
++ GAT D +ECE G C + SC N+ G + C C+PGW G CH ++++
Sbjct: 1266 QLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECH-DLDE 1324
Query: 465 CRGQ---CQHGGTCKDLVNGYQCVCPRGFGGR--HCELERDECASS-PCHSGGLCEDLAD 518
C Q C G C ++ Y+C C +GF G CE +RDECA + G C +
Sbjct: 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVDLCDNGQCLNAPG 1383
Query: 519 GFHCHCPQGFSGP----LCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD----DFGGKN 570
G+ C C GF C+ DVD C C NL G + C C D GG N
Sbjct: 1384 GYRCECEMGFDPTEDHRACQ-DVDECAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGN 1442
Query: 571 CSVPRE-----PCPGGACRVIDG-----CGSD-----AGPGMPGTAASGVCGPHGRCVSQ 615
C+ E C G C G C D +G G T A G C
Sbjct: 1443 CTDINECADPVNCINGVCINTPGSYLCSCPQDFELNPSGVGCVDTRA-GNCFLETHDRGD 1501
Query: 616 PGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC-IDEVDAFRCFCPSGWEG------ 668
G + S G T C ++ G PC C + +R CP G EG
Sbjct: 1502 SGISCSAEIGVGVTRASCCCSLGRAWGNPCE---LCPMANTTEYRTLCPGG-EGFQPNRI 1557
Query: 669 --ELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDAYTCS 722
L D + LP C G C + F C C G+ + C + +C ++
Sbjct: 1558 TVILEDIDECQELPGLCQG-GDCVNTFGSFQCECPPGYHLSEHTRICEDID-ECSTHSGI 1615
Query: 723 NG-GTCYDSGDTFRCACPPGW----KGSTCAVAKNSSCLPNPCVNGGTC----------- 766
G GTCY++ + C CP + G+ C + S C + GTC
Sbjct: 1616 CGPGTCYNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRH---YNGTCQNELAFNVTRK 1672
Query: 767 -------VGSGASFSC-------------ICRDGWEGRTCTHNT------NDCNPLP--C 798
+G + C +C + G +T ++C +P C
Sbjct: 1673 MCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPGFLTDIHTGKPLDIDECGEIPAIC 1732
Query: 799 YNGGICVDGVNWFRCECAPGFAGPDCRI---NIDECQS--SPCAYGATCVDEINGYRCSC 853
N GIC++ + FRCEC GF + ++DEC S SPC A C++ YRC C
Sbjct: 1733 AN-GICINQIGSFRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINIPGSYRCKC 1791
Query: 854 PPG 856
G
Sbjct: 1792 TRG 1794
Score = 209 bits (532), Expect = 1e-53
Identities = 226/854 (26%), Positives = 337/854 (39%), Gaps = 154/854 (18%)
Query: 167 SHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQY 226
SH ++ E + L G A + + + DE N C+ + G Y C +
Sbjct: 1817 SHGDCMDTEGSYMCLCHRGFQASADQTLCMDIDECDRQPCGNGTCK---NIIGSYNCLCF 1873
Query: 227 G------NKACMD-----GWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQ----GR 271
N C+D +G+ C+ C H C C G++ G+
Sbjct: 1874 PGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFH--------CLCQDGFELTADGK 1925
Query: 272 FC---DECVPYPG-CVHGSCVE---PWQCNCETNWGGLLCDK--DLNYCGSHHPCTNGGT 322
C +EC+ G C+ G+C ++C C + + D D++ C GT
Sbjct: 1926 NCVDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQ-VQSDHCIDIDECSEEPNLCLFGT 1984
Query: 323 CINAEPDQYRCTCPDGY----SGRNC-------------------------EKAEHACTS 353
C N+ P ++C CP G+ +G C K C+
Sbjct: 1985 CTNS-PGSFQCLCPPGFVLSDNGHRCFDTRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSK 2043
Query: 354 NPCANGGS-CHEVP----SGFECHCPSGWS---GPTCAL-DIDECASNP-CAAGGTCVDQ 403
P G C P + F+ CP G GP + D++ECA NP G CV+
Sbjct: 2044 RPGEGWGDPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTNGVCVNT 2103
Query: 404 VDGFECICPE----QWVGATCQLDANECE-GKPCLNAFSCKNLIGGYYCDCIPGWKG--- 455
F C CP + G C +D +EC G PC +C N+IGG+ C C G++
Sbjct: 2104 DGSFRCECPFGYSLDFTGINC-VDTDECSVGHPCGQG-TCTNVIGGFECACADGFEPGLM 2161
Query: 456 INCHINVNDCR-GQCQHGGTCKDLVNGYQCVCPRGF----GGRHCELERDECASSP--CH 508
+ C ++++C C + Y C CP G+ G C + DECA CH
Sbjct: 2162 MTCE-DIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDECADGQQDCH 2219
Query: 509 SGGL-CEDLADGFHCHCPQGF-----SGPLCEVDVDL-CEPSPCRNGARCYNLEGDYYCA 561
+ G+ C++L F C CP G SG C D + +P C NG RC N G + C
Sbjct: 2220 ARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNG-RCVNTAGSFRCD 2278
Query: 562 CPDDFGGK----NCSVPRE-PCPGGACRVIDGCGSDAGPGMPGTAASGVCG------PHG 610
C + F C R+ PC + + C S + T A CG P
Sbjct: 2279 CDEGFQPSPTLTECHDIRQGPCFAEVLQTM--CRSLSSSSEAVTRAECCCGGGRGWGPRC 2336
Query: 611 RCVSQPGGN-FSCICDSGFTGTYCHENIDDC--LGQPCRNGGTCIDEVDAFRCFCPSGWE 667
PG + + +C G T ++D+C L C +G CI+ + +FRC C +G+
Sbjct: 2337 ELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHG-ECINSLGSFRCHCQAGYT 2395
Query: 668 GELCDT---NPNDC--LPDPCHSRGRCYDLVNDFYCACDDGW----KGKTCHSREFQCDA 718
+ T + ++C +P PC C + F C+C G+ G+TC + +C +
Sbjct: 2396 PDATATTCLDMDECSQVPKPCTFL--CKNTKGSFLCSCPRGYLLEEDGRTCKDLD-ECTS 2452
Query: 719 YTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCL--PNPCVNGGTCVGSGASFSCI 776
+ C ++ F C CPPG+ A N C P PC G C + SF C
Sbjct: 2453 RQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAHGHCHNTPGSFRCE 2512
Query: 777 CRDGWEGRTCTHNTNDCN----PLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINI 828
C G+ + H D N P C +G C + + +RC C GF C ++
Sbjct: 2513 CHQGFTLVSSGHGCEDVNECDGPHRCQHG--CQNQLGGYRCSCPQGFTQHSQWAQC-VDE 2569
Query: 829 DECQSSPCAYG-ATCVDEINGYRCSCPPG----RAGPRCQEVIGFGRSCWSRGTPFPHGS 883
+EC SP G A+C + + G+RC CP G +A CQEV C R P +
Sbjct: 2570 NECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEV----DECAGRRGPCSYSC 2625
Query: 884 SWVEDCNSCRCLDG 897
+ C C G
Sbjct: 2626 ANTPGGFLCGCPQG 2639
Score = 191 bits (484), Expect = 5e-48
Identities = 212/824 (25%), Positives = 306/824 (37%), Gaps = 165/824 (20%)
Query: 229 KACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCV 288
+ C+D + C A+ K C G EC C+ G F + C P
Sbjct: 609 RVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECCCANPDHG-FGEPCQLCPAKDSAE-- 665
Query: 289 EPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGY----SGRNC 344
+Q C + G +D+N C G C N YRC C GY SG++C
Sbjct: 666 --FQALCSSGLGITTDGRDINECALDPEVCANGVCENLR-GSYRCVCNLGYEAGASGKDC 722
Query: 345 EKAEHACTSNPCANGGSCHEVPSGFECHCPSG---WSGPTCALDIDECASNPCAAGGTCV 401
+ ++ + G C P + C CP G W D+DEC S+PC + G C
Sbjct: 723 TDVDECALNSLLCDNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSPCVS-GVCR 781
Query: 402 DQVDGFECICPE------------QWVGATCQLDANECEGKPCLNAFS----CKNLIG-- 443
+ + C C TC L E + L S C +G
Sbjct: 782 NLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCATLGAA 841
Query: 444 -GYYCD-------CIPGW---KGINCHINVNDCR---GQCQHGGTCKDLVNGYQCVCPRG 489
G C+ C G+ G+ C +VN+C G C + G C + ++C CP G
Sbjct: 842 WGSPCERCEIDPACARGFARMTGVTCD-DVNECESFPGVCPN-GRCVNTAGSFRCECPEG 899
Query: 490 F----GGRHC----------ELERDECASS----------PCHSGGL----CEDLAD--- 518
GR C + DEC + C G + CE D
Sbjct: 900 LMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPES 959
Query: 519 -GFHCHCPQG--------FSGPLCEVDVDLCE--PSPCRNGARCYNLEGDYYCACPDDFG 567
F CP+G SG DV+ C+ P C +G C N G ++CAC F
Sbjct: 960 LEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGT-CRNTVGSFHCACAGGFA 1018
Query: 568 ----GKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCI 623
+NC+ E CR+ + +CG G CV+ P G+F C
Sbjct: 1019 LDAQERNCTDIDE------CRI----------------SPDLCG-QGTCVNTP-GSFECE 1054
Query: 624 C----DSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWE----GELCDT 673
C +SGF ++D+C P CR GGTC + +++C CP G E G C+
Sbjct: 1055 CFPGYESGFMLMKNCMDVDECARDPLLCR-GGTCTNTDGSYKCQCPPGHELTAKGTACED 1113
Query: 674 NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGT---CYDS 730
L D G+C +++ F C+C G++ + NGG C ++
Sbjct: 1114 IDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCVDINECRVQNGGCDVHCINT 1173
Query: 731 GDTFRCACPPGWK----GSTCAVAKNSSCLPNPCV-NGGTCVGSGASFSCICRDGW---- 781
++RC+C G+ G CA C NP V + G C C+C DG+
Sbjct: 1174 EGSYRCSCGQGYSLMPDGRACADV--DECEENPRVCDQGHCTNMPGGHRCLCYDGFMATP 1231
Query: 782 EGRTCTH-NTNDCNPLPCYNGGICVDGVNWFRCECAPGF---AGPDCRINIDECQ--SSP 835
+ RTC + D NP C +G C + F C C G+ G ++DEC+
Sbjct: 1232 DMRTCVDVDECDLNPHICLHGD-CENTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHN 1290
Query: 836 CAYGATCVDEINGYRCSCPPGRAGP--RC---QEVIGFGRSCWSRGTPFPHGSSWVEDCN 890
C A+C++ + C C PG G C E + C RG S+ C
Sbjct: 1291 CDSHASCLNIPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCR 1350
Query: 891 SCRCLDG-----RRDCSK--VWCGWKPCLLAGQPEALSAQCPLG 927
DG R +C++ C CL A P +C +G
Sbjct: 1351 QGFAGDGFFCEDRDECAENVDLCDNGQCLNA--PGGYRCECEMG 1392
Score = 172 bits (437), Expect = 1e-42
Identities = 174/635 (27%), Positives = 244/635 (38%), Gaps = 166/635 (26%)
Query: 233 DGWMGKECK------EAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPG-CVHG 285
+GW G C+ A ++ C HG P + R +EC PG C +G
Sbjct: 2047 EGW-GDPCELCPQEGSAAFQELCPFGHGAVPGPDDSR-------EDVNECAENPGVCTNG 2098
Query: 286 SCVEP---WQCNCETNWG----GLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
CV ++C C + G+ C D + C HPC G TC N + C C DG
Sbjct: 2099 VCVNTDGSFRCECPFGYSLDFTGINC-VDTDECSVGHPCGQG-TCTNVIGG-FECACADG 2155
Query: 339 YSG---RNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWS----GPTCALDIDECAS 391
+ CE + C+ NP CH + C CP+G++ G C D+DECA
Sbjct: 2156 FEPGLMMTCEDIDE-CSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDECAD 2213
Query: 392 NP--CAAGGT-CVDQVDGFECICPEQW-----VGATCQLDANECEGKP--CLNAFSCKNL 441
C A G C + + F C+CP G C D NEC +P C+N C N
Sbjct: 2214 GQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCT-DDNECHAQPDLCVNG-RCVNT 2271
Query: 442 IGGYYCDCIPGWKG----INCH-INVNDCRGQ-----CQHGGTCKDLVNGYQCVCPRGFG 491
G + CDC G++ CH I C + C+ + + V +C C G G
Sbjct: 2272 AGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRG 2331
Query: 492 -GRHCEL------------------------ERDECAS-SPCHSGGLCEDLADGFHCHCP 525
G CEL + DEC + + G C + F CHC
Sbjct: 2332 WGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRCHCQ 2391
Query: 526 QGFSGPLCE---VDVDLCE--PSPCRNGARCYNLEGDYYCACPDDF----GGKNCSVPRE 576
G++ +D+D C P PC C N +G + C+CP + G+ C E
Sbjct: 2392 AGYTPDATATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDE 2449
Query: 577 ---------------------PCPGG------ACRVIDGCGSDAGPGMPGTAASGVCGPH 609
CP G AC D C + GP CG H
Sbjct: 2450 CTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGP----------CGAH 2499
Query: 610 GRCVSQPGGNFSCICDSGFT----GTYCHENIDDCLG-QPCRNGGTCIDEVDAFRCFCPS 664
G C + PG +F C C GFT G C E++++C G C++G C +++ +RC CP
Sbjct: 2500 GHCHNTPG-SFRCECHQGFTLVSSGHGC-EDVNECDGPHRCQHG--CQNQLGGYRCSCPQ 2555
Query: 665 GWE-----GELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW----------KGKTC 709
G+ + D N P C S C + + F C C G+ + C
Sbjct: 2556 GFTQHSQWAQCVDENECALSPPTCGSAS-CRNTLGGFRCVCPSGFDFDQALGGCQEVDEC 2614
Query: 710 HSREFQCDAYTCSN--GGTCYDSGDTFRCACPPGW 742
R C +Y+C+N GG F C CP G+
Sbjct: 2615 AGRRGPC-SYSCANTPGG--------FLCGCPQGY 2640
Score = 169 bits (427), Expect = 2e-41
Identities = 182/674 (27%), Positives = 267/674 (39%), Gaps = 116/674 (17%)
Query: 253 HGGCTVPGECRCSYGWQGRFCDECVPYPGCVHG--SCVEPWQCNCETNWGGLLCDKDLNY 310
H G PG C Y G + C V+G +C++ + C ++ G C +L +
Sbjct: 1612 HSGICGPGTC---YNTLGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGT-CQNELAF 1667
Query: 311 -------CGSHH-------PCTNGGTCINAEPDQYRCTC--------PDGYSGRNCEKAE 348
C S++ PC T I+ PD Y+ C D ++G+ + E
Sbjct: 1668 NVTRKMCCCSYNIGQAWNRPCEACPTPIS--PD-YQILCGNQAPGFLTDIHTGKPLDIDE 1724
Query: 349 HACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCAL---DIDECAS--NPCAAGGTCVDQ 403
CANG +++ S F C CP+G++ + L D+DEC S +PC C++
Sbjct: 1725 CGEIPAICANGICINQIGS-FRCECPAGFNYNSILLACEDVDECGSRESPCQQNADCINI 1783
Query: 404 VDGFECICPEQWV---GATCQLDANECEGKPCLNAFS-CKNLIGGYYCDCIPGWKGI--- 456
+ C C + G C + NEC P + + C + G Y C C G++
Sbjct: 1784 PGSYRCKCTRGYKLSPGGAC-VGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQASADQ 1842
Query: 457 NCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRH---CELERDECAS---SPCHSG 510
+++++C Q GTCK+++ Y C+C GF H C ++ DEC + C G
Sbjct: 1843 TLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDC-VDFDECTTLVGQVCRFG 1901
Query: 511 GLCEDLADGFHCHCPQGF----SGPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACPD 564
C + A FHC C GF G C VD + C C G C NLEG + C CP
Sbjct: 1902 H-CLNTAGSFHCLCQDGFELTADGKNC-VDTNECLSLAGTCLPGT-CQNLEGSFRCICPP 1958
Query: 565 DFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 624
F C ID C + + GT C + P G+F C+C
Sbjct: 1959 GF----------QVQSDHCIDIDECSEEPNLCLFGT-----------CTNSP-GSFQCLC 1996
Query: 625 DSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGE----LCDTNPNDCLP 680
GF +N C C +A +C P + C P +
Sbjct: 1997 PPGFV---LSDNGHRCFD---TRQSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWG 2050
Query: 681 DPCHSRGRCYDLVNDFYCACDDGWKGKTCHSRE--FQC--DAYTCSNGGTCYDSGDTFRC 736
DPC + C G SRE +C + C+N G C ++ +FRC
Sbjct: 2051 DPCELCPQEGSAAFQELCPFGHGAVPGPDDSREDVNECAENPGVCTN-GVCVNTDGSFRC 2109
Query: 737 ACPPGWK----GSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEG---RTCTHN 789
CP G+ G C V + + +PC GTC F C C DG+E TC +
Sbjct: 2110 ECPFGYSLDFTGINC-VDTDECSVGHPC-GQGTCTNVIGGFECACADGFEPGLMMTC-ED 2166
Query: 790 TNDCNPLPCYNGGICVDGVNWFRCECAPGFA----GPDCRINIDEC---QSSPCAYGATC 842
++C+ P C + + C C G+ G CR ++DEC Q A G C
Sbjct: 2167 IDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCR-DVDECADGQQDCHARGMEC 2225
Query: 843 VDEINGYRCSCPPG 856
+ I + C CPPG
Sbjct: 2226 KNLIGTFACVCPPG 2239
Score = 167 bits (422), Expect = 7e-41
Identities = 222/883 (25%), Positives = 309/883 (34%), Gaps = 200/883 (22%)
Query: 219 GHYTCDQYGNKACMDGWMGKEC---KEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDE 275
G C Q C DG + C + + C C ++GG C C G+ G C +
Sbjct: 91 GEGFCSQPNLCTCADGTLAPSCGVSRGSGCSVSC--MNGGTCRGASCLCQKGYTGTVCGQ 148
Query: 276 CVPYPGCVHGS-CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCT 334
+ GC +G C+ P +C C + G C++D G C +
Sbjct: 149 PICDRGCHNGGRCIGPNRCACVYGFMGPQCERDY----------RTGPCFGQVGPE---G 195
Query: 335 CPDGYSGRNCEKAEHACTSNPCANGGSCHEVPS-------GFECHCPSGWSGPTCALDID 387
C +G C KA C + A G C P+ GF + +G D+D
Sbjct: 196 CQHQLTGLVCTKA-LCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG-----ACQDVD 249
Query: 388 ECASNP-CAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYY 446
EC + P GG+CV+ V F C CP VG + CE FS L GG
Sbjct: 250 ECQAVPGLCQGGSCVNMVGSFHCRCP---VGHRLSDSSAACEDYRAGACFSV--LFGGRC 304
Query: 447 CDCIPGWKGINCHINVNDC---RGQCQHGGTCKDLV-----NGYQCVCPR---------- 488
+ G H C RG+C G +L N +Q +C +
Sbjct: 305 AGDLAG------HYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPG 358
Query: 489 ------GFGGR-------------HCELERDECASSPCHS-------------------- 509
GFG H R + P +S
Sbjct: 359 LFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNL 418
Query: 510 --GGLCEDLADGFHCHCPQGFSGPL---CEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564
G C + C C G++ + C +DVD C SPC +G C N+ G Y+C C
Sbjct: 419 CLNGRCLPTPSSYRCECNVGYTQDVRGEC-IDVDECTSSPCHHG-DCVNIPGTYHCRC-- 474
Query: 565 DFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCIC 624
+ G + R+ AC +D C + G+C GRCV+ G+F C+C
Sbjct: 475 -YPGFQATPTRQ-----ACVDVDEC----------IVSGGLC-HLGRCVNTE-GSFQCVC 516
Query: 625 DSGF----TGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW----EGELCDTNPN 676
++GF G C ++ + C N G C++E +F C C G+ G C + +
Sbjct: 517 NAGFELSPDGKNCVDHNECATSTMCVN-GVCLNEDGSFSCLCKPGFLLAPGGHYC-MDID 574
Query: 677 DCLPDPCHSRGRCYDLVNDFYCAC----DDGWKGKTCHSREFQCDAYTCSNGGTCYD--- 729
+C G C + F C C G G+ C + Y G+C
Sbjct: 575 ECQTPGICVNGHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFP 634
Query: 730 ---SGDTFRCACPPGWKGSTCAV--AKNSS---------------------CL--PNPCV 761
+ CA P G C + AK+S+ C P C
Sbjct: 635 GTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCA 694
Query: 762 NGGTCVGSGASFSCICRDGWE----GRTCTHNTNDC--NPLPCYNGGICVDGVNWFRCEC 815
N G C S+ C+C G+E G+ CT + ++C N L C NG C + + C C
Sbjct: 695 N-GVCENLRGSYRCVCNLGYEAGASGKDCT-DVDECALNSLLCDNGW-CQNSPGSYSCSC 751
Query: 816 APGF-AGPDCRI--NIDECQSSPCAYGATCVDEINGYRCSCPPGR----AGPRCQEVIGF 868
PGF D I ++DEC SSPC G C + Y C C PG +G C +
Sbjct: 752 PPGFHFWQDTEICKDVDECLSSPCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLD--ST 808
Query: 869 GRSCW-----SRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQ 923
+CW SR G+S +C C L C P G
Sbjct: 809 KGTCWLKIQESRCEVNLQGASLRSEC--CATLGAAWGSPCERCEIDPACARGFARMTGVT 866
Query: 924 CPLGQRCLEKAPGQCLRPPCEAWGECGAEEPPSTPCLPRSGHL 966
C C E PG C C E P L SG L
Sbjct: 867 CDDVNEC-ESFPGVCPNGRCVNTAGSFRCECPEGLMLDASGRL 908
Score = 158 bits (400), Expect = 3e-38
Identities = 214/835 (25%), Positives = 303/835 (36%), Gaps = 203/835 (24%)
Query: 180 SLHFSGHVAHLELQIRVRCDENYYSATCNKFC---RPRNDFFGHYTCDQYGNKACMDG-- 234
S H V H C E+Y + C R D GHYT Q C D
Sbjct: 269 SFHCRCPVGHRLSDSSAAC-EDYRAGACFSVLFGGRCAGDLAGHYTRRQ----CCCDRGR 323
Query: 235 -WMGKECKEAVCKQGCNLLHGGCT-----VPGECRCSYGWQGRFCDECVPYPGCV----H 284
W E +G N C +PG G G + P G H
Sbjct: 324 CWAAGPVPELCPPRGSNEFQQLCAQRLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPH 383
Query: 285 GSCVE--PWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYS-- 340
GS P +N G ++ ++ C G C+ P YRC C GY+
Sbjct: 384 GSDARGIPSLGPGNSNIGTATLNQTIDICRHFTNLCLNGRCLPT-PSSYRCECNVGYTQD 442
Query: 341 --GRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSG-PT--CALDIDEC-ASNPC 394
G + E CTS+PC + G C +P + C C G+ PT +D+DEC S
Sbjct: 443 VRGECIDVDE--CTSSPC-HHGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGL 499
Query: 395 AAGGTCVDQVDGFECICPEQWV----GATCQLDANEC-EGKPCLNAFSCKNLIGGYYCDC 449
G CV+ F+C+C + G C +D NEC C+N C N G + C C
Sbjct: 500 CHLGRCVNTEGSFQCVCNAGFELSPDGKNC-VDHNECATSTMCVNGV-CLNEDGSFSCLC 557
Query: 450 IPGW---KGINCHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFG----GRHC----- 495
PG+ G + +++++C+ G C + G C + ++C C G GR C
Sbjct: 558 KPGFLLAPGGHYCMDIDECQTPGICVN-GHCTNTEGSFRCQCLGGLAVGTDGRVCVDTHV 616
Query: 496 ------ELERDECA--------------SSPCHSGG----LC--EDLADGFHCHCPQGFS 529
+E+ CA ++P H G LC +D A+ F C G
Sbjct: 617 RSTCYGAIEKGSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAE-FQALCSSGLG 675
Query: 530 GPLCEVDVDLC--EPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVID 587
D++ C +P C NG C NL G Y C C + G C +D
Sbjct: 676 ITTDGRDINECALDPEVCANGV-CENLRGSYRCVCNLGY--------EAGASGKDCTDVD 726
Query: 588 GCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGF---TGTYCHENIDDCLGQP 644
C A + + +G C + P G++SC C GF T +++D+CL P
Sbjct: 727 EC-----------ALNSLLCDNGWCQNSP-GSYSCSCPPGFHFWQDTEICKDVDECLSSP 774
Query: 645 CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYC------ 698
C + G C + ++ C C G D + CL ++G C+ + + C
Sbjct: 775 CVS-GVCRNLAGSYTCKC---GPGSRLDPSGTFCLDS---TKGTCWLKIQESRCEVNLQG 827
Query: 699 --------------------------ACDDGW---KGKTCHSREFQCDAY--TCSNGGTC 727
AC G+ G TC +C+++ C N G C
Sbjct: 828 ASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVN-ECESFPGVCPN-GRC 885
Query: 728 YDSGDTFRCACPPGW----KGSTCAVAKNSSC------------LPNPCVNGGTCVGSGA 771
++ +FRC CP G G C + C LP C GA
Sbjct: 886 VNTAGSFRCECPEGLMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGA 945
Query: 772 ---------------SFSCIC--------RDGWEGRTCTHNTNDCNPLP-CYNGGICVDG 807
F+ +C RD GR + N+C P G C +
Sbjct: 946 VWGVECEACPDPESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNT 1005
Query: 808 VNWFRCECAPGFA----GPDCRINIDECQSSP--CAYGATCVDEINGYRCSCPPG 856
V F C CA GFA +C +IDEC+ SP C G TCV+ + C C PG
Sbjct: 1006 VGSFHCACAGGFALDAQERNC-TDIDECRISPDLCGQG-TCVNTPGSFECECFPG 1058
Score = 135 bits (339), Expect = 3e-31
Identities = 138/482 (28%), Positives = 185/482 (38%), Gaps = 98/482 (20%)
Query: 231 CMDGWM-----GKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFC---DECVPYPG- 281
C DG G ECK + C G +PG G C +EC P
Sbjct: 2211 CADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGS--------GEGCTDDNECHAQPDL 2262
Query: 282 CVHGSCVEP---WQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
CV+G CV ++C+C+ G L C G C AE Q C
Sbjct: 2263 CVNGRCVNTAGSFRCDCDE---GFQPSPTLTECHD----IRQGPCF-AEVLQTMC----- 2309
Query: 339 YSGRNCEKAEHACTSNPCANGGS------CHEVP----SGFECHCPSGWSGPTCALDIDE 388
R+ + A T C GG C P S + CP G D+DE
Sbjct: 2310 ---RSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDE 2366
Query: 389 CA--SNPCAAGGTCVDQVDGFECICPEQWVG---ATCQLDANECEGKPCLNAFSCKNLIG 443
C ++ CA G C++ + F C C + AT LD +EC P F CKN G
Sbjct: 2367 CRMLAHLCAHG-ECINSLGSFRCHCQAGYTPDATATTCLDMDECSQVPKPCTFLCKNTKG 2425
Query: 444 GYYCDCIPGW----KGINCHINVNDCRGQ---CQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
+ C C G+ G C ++++C + CQ C + V + C CP GF H
Sbjct: 2426 SFLCSCPRGYLLEEDGRTCK-DLDECTSRQHNCQF--LCVNTVGAFTCRCPPGFTQHHQA 2482
Query: 497 -LERDECASSP--CHSGGLCEDLADGFHCHCPQGF----SGPLCEVDVDLCE-PSPCRNG 548
+ DEC++ P C + G C + F C C QGF SG CE DV+ C+ P C++G
Sbjct: 2483 CFDNDECSAQPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCE-DVNECDGPHRCQHG 2541
Query: 549 ARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGP 608
C N G Y C+CP F + C + C P T S C
Sbjct: 2542 --CQNQLGGYRCSCPQGF--------TQHSQWAQCVDENECALS-----PPTCGSASC-- 2584
Query: 609 HGRCVSQPGGNFSCICDSGFTGTY----CHENIDDCLGQPCRNGGTCIDEVDAFRCFCPS 664
G F C+C SGF C E +D+C G+ +C + F C CP
Sbjct: 2585 -----RNTLGGFRCVCPSGFDFDQALGGCQE-VDECAGRRGPCSYSCANTPGGFLCGCPQ 2638
Query: 665 GW 666
G+
Sbjct: 2639 GY 2640
Score = 80.5 bits (197), Expect = 9e-15
Identities = 63/207 (30%), Positives = 83/207 (40%), Gaps = 24/207 (11%)
Query: 233 DGWMGKECKEAVCKQ-GCNLLHGGCTVPGECRCSYGW--QGRFC---DECVPYPG-C-VH 284
DG K+ E +Q C L CRC G+ + C DEC PG C H
Sbjct: 2440 DGRTCKDLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQPGPCGAH 2499
Query: 285 GSCVE-PWQCNCETNWGGLLCD-----KDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDG 338
G C P CE + G L +D+N C H C +G C N + YRC+CP G
Sbjct: 2500 GHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHG--CQN-QLGGYRCSCPQG 2556
Query: 339 YSGRN----CEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTC---ALDIDECAS 391
++ + C S P SC GF C CPSG+ ++DECA
Sbjct: 2557 FTQHSQWAQCVDENECALSPPTCGSASCRNTLGGFRCVCPSGFDFDQALGGCQEVDECAG 2616
Query: 392 NPCAAGGTCVDQVDGFECICPEQWVGA 418
+C + GF C CP+ + A
Sbjct: 2617 RRGPCSYSCANTPGGFLCGCPQGYFRA 2643
Score = 67.0 bits (162), Expect = 1e-10
Identities = 63/234 (26%), Positives = 84/234 (35%), Gaps = 55/234 (23%)
Query: 658 FRCFCPSGWEGELCDTNP--NDCLPDPCH---SRGRCYDLVNDFYCACDDGWKGKTCHSR 712
F +C GW T P + C+ C G C C C DG +C
Sbjct: 64 FHAYCCPGWR-----TFPGRSQCVVPICRRACGEGFCSQ---PNLCTCADGTLAPSCGVS 115
Query: 713 EFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGAS 772
+ +C NGGTC + C C G+ G+ C C NGG C+G
Sbjct: 116 RGSGCSVSCMNGGTCRGAS----CLCQKGYTGTVCG----QPICDRGCHNGGRCIGPNR- 166
Query: 773 FSCICRDGWEGRTCT--HNTNDC----NPLPCYN---GGICVD-------GVNW-FRCEC 815
C C G+ G C + T C P C + G +C G W CE
Sbjct: 167 --CACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCEL 224
Query: 816 APGFAGPDCRI------------NIDECQSSP-CAYGATCVDEINGYRCSCPPG 856
P P CR ++DECQ+ P G +CV+ + + C CP G
Sbjct: 225 CPAQPHP-CRRGFIPNIHTGACQDVDECQAVPGLCQGGSCVNMVGSFHCRCPVG 277
Score = 65.5 bits (158), Expect = 3e-10
Identities = 77/313 (24%), Positives = 108/313 (34%), Gaps = 96/313 (30%)
Query: 731 GDTFRCACPPGWK-----------------------------------GSTCAVAKNSSC 755
G F C PGW+ +C V++ S C
Sbjct: 61 GSRFHAYCCPGWRTFPGRSQCVVPICRRACGEGFCSQPNLCTCADGTLAPSCGVSRGSGC 120
Query: 756 LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCEC 815
+ C+NGGTC G+ SC+C+ G+ G C D C+NGG C+ G N RC C
Sbjct: 121 SVS-CMNGGTCRGA----SCLCQKGYTGTVCGQPICDRG---CHNGGRCI-GPN--RCAC 169
Query: 816 APGFAGPDCRINIDECQSSPCAYGAT----CVDEINGYRCS-----CPPGRA-GPRCQEV 865
GF GP C + ++ PC +G C ++ G C+ GRA G C+
Sbjct: 170 VYGFMGPQCE---RDYRTGPC-FGQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELC 225
Query: 866 IGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCP 925
C P H + +D + C+ + G C C+ + +CP
Sbjct: 226 PAQPHPCRRGFIPNIHTGA-CQDVDECQAVPG-------LCQGGSCV--NMVGSFHCRCP 275
Query: 926 LGQR-------CLEKAPGQCL------------------RPPCEAWGECGAEEPPSTPCL 960
+G R C + G C R C G C A P C
Sbjct: 276 VGHRLSDSSAACEDYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCP 335
Query: 961 PR-SGHLDNNCAR 972
PR S CA+
Sbjct: 336 PRGSNEFQQLCAQ 348
>gi|153946395 tenascin C precursor [Homo sapiens]
Length = 2201
Score = 214 bits (544), Expect = 5e-55
Identities = 176/544 (32%), Positives = 225/544 (41%), Gaps = 105/544 (19%)
Query: 333 CTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASN 392
C C G+ G NC + E C N C G C + +C C G++G C+ +
Sbjct: 174 CVCEPGWKGPNCSEPE--CPGN-CHLRGRCID----GQCICDDGFTGEDCS---QLACPS 223
Query: 393 PCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPG 452
C G CV+ V CIC E + GA C + E PC + G C C G
Sbjct: 224 DCNDQGKCVNGV----CICFEGYAGADC---SREICPVPCSEEHG--TCVDG-LCVCHDG 273
Query: 453 WKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGL 512
+ G +C N C C + G C + +CVC GF G C + + C G
Sbjct: 274 FAGDDC--NKPLCLNNCYNRGRCVE----NECVCDEGFTGEDCS---ELICPNDCFDRGR 324
Query: 513 CEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCS 572
C + C+C +GF+G C C P C RC EG C C + F G +CS
Sbjct: 325 CINGT----CYCEEGFTGEDC--GKPTC-PHACHTQGRCE--EGQ--CVCDEGFAGVDCS 373
Query: 573 VPREP--------CPGGACRVIDG-CGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCI 623
R P C G C DG G+D G C HGRCV N C+
Sbjct: 374 EKRCPADCHNRGRCVDGRCECDDGFTGADCGE----LKCPNGCSGHGRCV-----NGQCV 424
Query: 624 CDSGFTGTYCHENIDDCLGQP--CRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD 681
CD G+TG C + L P C + G C++ +C C G++G C + P+
Sbjct: 425 CDEGYTGEDCSQ-----LRCPNDCHSRGRCVEG----KCVCEQGFKGYDCS---DMSCPN 472
Query: 682 PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPG 741
CH GRC VN C CDDG+ G+ C R+ D CSN G C D +C C G
Sbjct: 473 DCHQHGRC---VNGM-CVCDDGYTGEDCRDRQCPRD---CSNRGLCVDG----QCVCEDG 521
Query: 742 WKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNG 801
+ G CA SC PN C G CV C+C +G+ G+ C C P C+
Sbjct: 522 FTGPDCA---ELSC-PNDCHGQGRCVNG----QCVCHEGFMGKDCKEQR--C-PSDCHGQ 570
Query: 802 GICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPR 861
G CVDG +C C GF G DC C S C CV RC C G +G
Sbjct: 571 GRCVDG----QCICHEGFTGLDC--GQHSCPSD-CNNLGQCVSG----RCICNEGYSGED 619
Query: 862 CQEV 865
C EV
Sbjct: 620 CSEV 623
Score = 186 bits (471), Expect = 2e-46
Identities = 182/600 (30%), Positives = 234/600 (39%), Gaps = 151/600 (25%)
Query: 394 CAAGGTCVDQVDGFECICPEQWVGATCQLDANE-CEGKPCLNAFSCKNLIGGYYCDCIPG 452
C AG C C+ P AT +LD C G+ + C C C PG
Sbjct: 140 CTAGAGC--------CLQP-----ATGRLDTRPFCSGRGNFSTEGCG-------CVCEPG 179
Query: 453 WKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCEL--------ERDECAS 504
WKG NC + +C G C G C D QC+C GF G C ++ +C +
Sbjct: 180 WKGPNC--SEPECPGNCHLRGRCID----GQCICDDGFTGEDCSQLACPSDCNDQGKCVN 233
Query: 505 SPC-----HSGGLCE-------------DLADGFHCHCPQGFSGPLCEVDVDLCEPSPCR 546
C ++G C DG C C GF+G C + L + C
Sbjct: 234 GVCICFEGYAGADCSREICPVPCSEEHGTCVDGL-CVCHDGFAGDDCNKPLCL---NNCY 289
Query: 547 NGARCYNLEGDYYCACPDDFGGKNCS--------VPREPCPGGACRVIDG-CGSDAG-PG 596
N RC E C C + F G++CS R C G C +G G D G P
Sbjct: 290 NRGRCVENE----CVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPT 345
Query: 597 MPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD 656
P C GRC C+CD GF G C E C C N G C+D
Sbjct: 346 CP-----HACHTQGRCEEG-----QCVCDEGFAGVDCSEK--RCPAD-CHNRGRCVDG-- 390
Query: 657 AFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQC 716
RC C G+ G D C P+ C GRC VN C CD+G+ G+ C
Sbjct: 391 --RCECDDGFTG--ADCGELKC-PNGCSGHGRC---VNG-QCVCDEGYTGEDCSQLRCPN 441
Query: 717 DAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCI 776
D C + G C + +C C G+KG C+ + SC PN C G CV C+
Sbjct: 442 D---CHSRGRCVEG----KCVCEQGFKGYDCS---DMSC-PNDCHQHGRCVNG----MCV 486
Query: 777 CRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPC 836
C DG+ G C C P C N G+CVDG +C C GF GPDC + + C
Sbjct: 487 CDDGYTGEDC--RDRQC-PRDCSNRGLCVDG----QCVCEDGFTGPDC---AELSCPNDC 536
Query: 837 AYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN-SCRCL 895
CV NG +C C G G C+E + C S DC+ RC+
Sbjct: 537 HGQGRCV---NG-QCVCHEGFMGKDCKE-----QRCPS-------------DCHGQGRCV 574
Query: 896 DGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGAEEPP 955
DG+ C + + G L GQ S LGQ C+ G+C+ + +C PP
Sbjct: 575 DGQCICHEGFTG----LDCGQHSCPSDCNNLGQ-CVS---GRCICNEGYSGEDCSEVSPP 626
Score = 185 bits (470), Expect = 2e-46
Identities = 162/557 (29%), Positives = 220/557 (39%), Gaps = 117/557 (21%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCT 257
C+ + C++ P N D G C DG+ G++C + C CN G
Sbjct: 176 CEPGWKGPNCSEPECPGNCHLRGRCID--GQCICDDGFTGEDCSQLACPSDCN--DQGKC 231
Query: 258 VPGECRCSYGWQGRFCD-ECVPYP-GCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHH 315
V G C C G+ G C E P P HG+CV+ C C + G C+K L C ++
Sbjct: 232 VNGVCICFEGYAGADCSREICPVPCSEEHGTCVD-GLCVCHDGFAGDDCNKPL--CLNN- 287
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPS 375
C N G C+ E C C +G++G +C +E C N C + G C C+C
Sbjct: 288 -CYNRGRCVENE-----CVCDEGFTGEDC--SELIC-PNDCFDRGRC----INGTCYCEE 334
Query: 376 GWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNA 435
G++G C + C G C + +C+C E + G C C C N
Sbjct: 335 GFTGEDCG---KPTCPHACHTQGRCEEG----QCVCDEGFAGVDC--SEKRCPA-DCHNR 384
Query: 436 FSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHC 495
C + G C+C G+ G +C C C G C VNG QCVC G+ G C
Sbjct: 385 GRC---VDG-RCECDDGFTGADC--GELKCPNGCSGHGRC---VNG-QCVCDEGYTGEDC 434
Query: 496 ELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLE 555
R + CHS G C + C C QGF G C D+ P+ C RC N
Sbjct: 435 SQLR---CPNDCHSRGRCVE----GKCVCEQGFKGYDCS---DMSCPNDCHQHGRCVN-- 482
Query: 556 GDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ 615
C C D + G++C CP C G CV
Sbjct: 483 --GMCVCDDGYTGEDCR--DRQCPRD------------------------CSNRGLCV-- 512
Query: 616 PGGNFSCICDSGFTGTYCHENI--DDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDT 673
+ C+C+ GFTG C E +DC GQ G C++ +C C G+ G+ C
Sbjct: 513 ---DGQCVCEDGFTGPDCAELSCPNDCHGQ-----GRCVNG----QCVCHEGFMGKDCKE 560
Query: 674 N--PNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSG 731
P+D CH +GRC D C C +G+ G C D C+N G C
Sbjct: 561 QRCPSD-----CHGQGRCV----DGQCICHEGFTGLDCGQHSCPSD---CNNLGQCVSG- 607
Query: 732 DTFRCACPPGWKGSTCA 748
RC C G+ G C+
Sbjct: 608 ---RCICNEGYSGEDCS 621
Score = 82.4 bits (202), Expect = 2e-15
Identities = 81/265 (30%), Positives = 107/265 (40%), Gaps = 48/265 (18%)
Query: 721 CSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDG 780
CS G G C C PGWKG C+ + P C G C+ CIC DG
Sbjct: 161 CSGRGNFSTEG--CGCVCEPGWKGPNCSEPE----CPGNCHLRGRCIDG----QCICDDG 210
Query: 781 WEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGA 840
+ G C+ C P C + G CV+GV C C G+AG DC I C
Sbjct: 211 FTGEDCSQLA--C-PSDCNDQGKCVNGV----CICFEGYAGADCSREI--CPVPCSEEHG 261
Query: 841 TCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH-----GSSWVEDC------ 889
TCVD + C C G AG C + + +C++RG + EDC
Sbjct: 262 TCVDGL----CVCHDGFAGDDCNKPLCL-NNCYNRGRCVENECVCDEGFTGEDCSELICP 316
Query: 890 NSC----RCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEA 945
N C RC++G C + + G + C G+P A C RC E GQC+ A
Sbjct: 317 NDCFDRGRCINGTCYCEEGFTG-EDC---GKPTCPHA-CHTQGRCEE---GQCVCDEGFA 368
Query: 946 WGECGAEEPPSTPCLPRSGHLDNNC 970
+C + P+ C R +D C
Sbjct: 369 GVDCSEKRCPA-DCHNRGRCVDGRC 392
Score = 58.9 bits (141), Expect = 3e-08
Identities = 45/149 (30%), Positives = 61/149 (40%), Gaps = 44/149 (29%)
Query: 198 CDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCT 257
C++ + C + P ND G C G C +G+MGK+CKE C C HG
Sbjct: 518 CEDGFTGPDCAELSCP-NDCHGQGRCVN-GQCVCHEGFMGKDCKEQRCPSDC---HG--- 569
Query: 258 VPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPC 317
QGR CV G C+ C + GL C + + C S C
Sbjct: 570 -----------QGR----------CVDGQCI------CHEGFTGLDCGQ--HSCPS--DC 598
Query: 318 TNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
N G C++ RC C +GYSG +C +
Sbjct: 599 NNLGQCVSG-----RCICNEGYSGEDCSE 622
>gi|188528648 tenascin XB isoform 1 precursor [Homo sapiens]
Length = 4242
Score = 213 bits (543), Expect = 7e-55
Identities = 196/681 (28%), Positives = 250/681 (36%), Gaps = 137/681 (20%)
Query: 227 GNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGS 286
G C G+ G C C C G C V G C C G+ G C + GC
Sbjct: 200 GRCVCFPGYTGPSCGWPSCPGDCQG-RGRC-VQGVCVCRAGFSGPDCSQRSCPRGCSQRG 257
Query: 287 CVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEK 346
E +C C+ + G D C+ G C N RC C GY+G +C
Sbjct: 258 RCEGGRCVCDPGYTG----DDCGMRSCPRGCSQRGRCENG-----RCVCNPGYTGEDC-- 306
Query: 347 AEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG 406
+C C+ G C + C C G++G C C GG CVD
Sbjct: 307 GVRSCPRG-CSQRGRCKD----GRCVCDPGYTGEDCG---TRSCPWDCGEGGRCVDG--- 355
Query: 407 FECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR 466
C+C W G T +C + C + C C G+ G +C V C
Sbjct: 356 -RCVC---WPGYT----GEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDC--GVRSCP 405
Query: 467 GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQ 526
G C G C+D +CVC G+ G C C G CE+ C C
Sbjct: 406 GDCNQRGRCED----GRCVCWPGYTGTDC---GSRACPRDCRGRGRCENGV----CVCNA 454
Query: 527 GFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVI 586
G+SG C V C P CR RC + C C + G++C CPG
Sbjct: 455 GYSGEDC--GVRSC-PGDCRGRGRCESGR----CMCWPGYTGRDCGT--RACPGD----- 500
Query: 587 DGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCR 646
C GRCV + C+C+ GFTG C C G CR
Sbjct: 501 -------------------CRGRGRCV-----DGRCVCNPGFTGEDCGSR--RCPGD-CR 533
Query: 647 NGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKG 706
G C D V C C +G+ GE C T P C RG+C D C C+DG+ G
Sbjct: 534 GHGLCEDGV----CVCDAGYSGEDCSTR---SCPGGCRGRGQCL----DGRCVCEDGYSG 582
Query: 707 KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTC 766
+ C R+ D CS G C D C C G+ C++ +C P+ C G C
Sbjct: 583 EDCGVRQCPND---CSQHGVCQDG----VCICWEGYVSEDCSI---RTC-PSNCHGRGRC 631
Query: 767 VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRI 826
C+C G+ G TC T C P C G CV GV C C G+ G DC
Sbjct: 632 ----EEGRCLCDPGYTGPTCA--TRMC-PADCRGRGRCVQGV----CLCHVGYGGEDC-- 678
Query: 827 NIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWV 886
+E +S C G + +C C G GP C G C RG
Sbjct: 679 GQEEPPASACPGGCGPRELCRAGQCVCVEGFRGPDCAIQTCPG-DCRGRG---------- 727
Query: 887 EDCN--SCRCLDG--RRDCSK 903
+C+ SC C DG DC +
Sbjct: 728 -ECHDGSCVCKDGYAGEDCGE 747
Score = 210 bits (534), Expect = 8e-54
Identities = 201/700 (28%), Positives = 260/700 (37%), Gaps = 162/700 (23%)
Query: 293 CNCETNWGGLLCDK--DLNYCGSHHP---------CTNGGTCINAEPDQYRCTCPDGYSG 341
C+CE WGG C D S P C + G C+ RC C GY+G
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRG-----RCVCFPGYTG 210
Query: 342 RNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPCAAGGTCV 401
+C +C + C G C + C C +G+SGP C+ C+ G C
Sbjct: 211 PSC--GWPSCPGD-CQGRGRCVQGV----CVCRAGFSGPDCS---QRSCPRGCSQRGRC- 259
Query: 402 DQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHIN 461
+G C+C + G C + C + C C+N C C PG+ G +C
Sbjct: 260 ---EGGRCVCDPGYTGDDCGM--RSCP-RGCSQRGRCEN----GRCVCNPGYTGEDC--G 307
Query: 462 VNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSP--CHSGGLCEDLADG 519
V C C G CKD +CVC G+ G C S P C GG C D
Sbjct: 308 VRSCPRGCSQRGRCKD----GRCVCDPGYTGEDCGTR-----SCPWDCGEGGRCVD---- 354
Query: 520 FHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCP 579
C C G++G C C P CR RC + E C C + G +C V CP
Sbjct: 355 GRCVCWPGYTGEDCSTRT--C-PRDCRGRGRCEDGE----CICDTGYSGDDCGV--RSCP 405
Query: 580 GGACRVIDGCGSD---AGPGMPGT-----AASGVCGPHGRCVSQPGGNFSCICDSGFTGT 631
G C C PG GT A C GRC N C+C++G++G
Sbjct: 406 GD-CNQRGRCEDGRCVCWPGYTGTDCGSRACPRDCRGRGRCE-----NGVCVCNAGYSGE 459
Query: 632 YCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYD 691
C + C G CR G C ++ RC C G+ G C T P C RGRC D
Sbjct: 460 DC--GVRSCPGD-CRGRGRC----ESGRCMCWPGYTGRDCGTR---ACPGDCRGRGRCVD 509
Query: 692 ---------------------------LVNDFYCACDDGWKGKTCHSREFQCDAYTCSNG 724
L D C CD G+ G+ C +R C C
Sbjct: 510 GRCVCNPGFTGEDCGSRRCPGDCRGHGLCEDGVCVCDAGYSGEDCSTR--SCPG-GCRGR 566
Query: 725 GTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGR 784
G C D RC C G+ G C V + PN C G C CIC +G+
Sbjct: 567 GQCLDG----RCVCEDGYSGEDCGVRQ----CPNDCSQHGVCQDG----VCICWEGYVSE 614
Query: 785 TCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVD 844
C+ T C P C+ G C +G RC C PG+ GP C + C + C CV
Sbjct: 615 DCSIRT--C-PSNCHGRGRCEEG----RCLCDPGYTGPTCATRM--CPAD-CRGRGRCVQ 664
Query: 845 EINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNS--CRCLDGRR--D 900
+ C C G G C + +C P G E C + C C++G R D
Sbjct: 665 GV----CLCHVGYGGEDCGQEEPPASAC-------PGGCGPRELCRAGQCVCVEGFRGPD 713
Query: 901 CSKVWCGWKPCLLAGQPEALSAQCP-----LGQRCLEKAP 935
C+ C P G+ E C G+ C E+ P
Sbjct: 714 CAIQTC---PGDCRGRGECHDGSCVCKDGYAGEDCGEEVP 750
Score = 194 bits (494), Expect = 3e-49
Identities = 183/649 (28%), Positives = 246/649 (37%), Gaps = 138/649 (21%)
Query: 333 CTCPDGYSGRNCEKAEHA--CTSNPCANGGSCHEVPSGF------ECHCPSGWSGPTCAL 384
C+C G+ G C A S+P + GSC + + C C G++GP+C
Sbjct: 156 CSCEPGWGGPTCSDPTDAEIPPSSPPSASGSCPDDCNDQGRCVRGRCVCFPGYTGPSCGW 215
Query: 385 DIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGG 444
C + C G CV V C+C + G +C + C S + G
Sbjct: 216 P--SCPGD-CQGRGRCVQGV----CVCRAGFSGP-------DCSQRSCPRGCSQRGRCEG 261
Query: 445 YYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECAS 504
C C PG+ G +C + C C G C+ NG +CVC G+ G C + C
Sbjct: 262 GRCVCDPGYTGDDC--GMRSCPRGCSQRGRCE---NG-RCVCNPGYTGEDCGVR--SCPR 313
Query: 505 SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPD 564
C G C+D C C G++G C C P C G RC D C C
Sbjct: 314 G-CSQRGRCKD----GRCVCDPGYTGEDC--GTRSC-PWDCGEGGRCV----DGRCVCWP 361
Query: 565 DFGGKNCSV---PRE-----PCPGGACRVIDG-CGSDAGPGMPGTAASGVCGPHGRCVSQ 615
+ G++CS PR+ C G C G G D G + G C GRC
Sbjct: 362 GYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSGDDCGV----RSCPGDCNQRGRCEDG 417
Query: 616 PGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNP 675
C+C G+TGT C + CR G C + V C C +G+ GE C
Sbjct: 418 -----RCVCWPGYTGTDCGSR---ACPRDCRGRGRCENGV----CVCNAGYSGEDCGVRS 465
Query: 676 NDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR 735
P C RGRC C C G+ G+ C +R D C G C D R
Sbjct: 466 ---CPGDCRGRGRC----ESGRCMCWPGYTGRDCGTRACPGD---CRGRGRCVDG----R 511
Query: 736 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP 795
C C PG+ G C S P C G C C+C G+ G C+ T C P
Sbjct: 512 CVCNPGFTGEDCG----SRRCPGDCRGHGLCEDG----VCVCDAGYSGEDCS--TRSC-P 560
Query: 796 LPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 855
C G C+DG RC C G++G DC + +C + C+ C D + C C
Sbjct: 561 GGCRGRGQCLDG----RCVCEDGYSGEDCGVR--QCPND-CSQHGVCQDGV----CICWE 609
Query: 856 GRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAG 915
G C + +C RG RC +GR C + G
Sbjct: 610 GYVSEDCS-IRTCPSNCHGRG----------------RCEEGRCLCDPGYTG-------- 644
Query: 916 QPEALSAQCPLGQRCLEKAPGQCLRPPC---EAWG--ECGAEEPPSTPC 959
P + CP R G+C++ C +G +CG EEPP++ C
Sbjct: 645 -PTCATRMCPADCR----GRGRCVQGVCLCHVGYGGEDCGQEEPPASAC 688
Score = 155 bits (393), Expect = 2e-37
Identities = 146/563 (25%), Positives = 195/563 (34%), Gaps = 121/563 (21%)
Query: 195 RVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNK-----ACMDGWMGKECKEAVCKQGC 249
R C+ Y C PR C Q G C G+ G++C C C
Sbjct: 294 RCVCNPGYTGEDCGVRSCPRG-------CSQRGRCKDGRCVCDPGYTGEDCGTRSCPWDC 346
Query: 250 NLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLN 309
GG V G C C G+ G C C E +C C+T + G D
Sbjct: 347 G--EGGRCVDGRCVCWPGYTGEDCSTRTCPRDCRGRGRCEDGECICDTGYSG----DDCG 400
Query: 310 YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGF 369
C G C + RC C GY+G +C AC + C G C
Sbjct: 401 VRSCPGDCNQRGRC-----EDGRCVCWPGYTGTDC--GSRACPRD-CRGRGRC----ENG 448
Query: 370 ECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDA--NEC 427
C C +G+SG C + C + C G C + C+C + G C A +C
Sbjct: 449 VCVCNAGYSGEDCG--VRSCPGD-CRGRGRC----ESGRCMCWPGYTGRDCGTRACPGDC 501
Query: 428 EGK-PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVC 486
G+ C++ C C PG+ G +C C G C+ G C+D V CVC
Sbjct: 502 RGRGRCVDG----------RCVCNPGFTGEDC--GSRRCPGDCRGHGLCEDGV----CVC 545
Query: 487 PRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCR 546
G+ G C C C G C D C C G+SG C V C
Sbjct: 546 DAGYSGEDCSTR--SCPGG-CRGRGQCLD----GRCVCEDGYSGEDCGV-------RQCP 591
Query: 547 NGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVC 606
N + + D C C + + ++CS+ CP C
Sbjct: 592 NDCSQHGVCQDGVCICWEGYVSEDCSI--RTCPSN------------------------C 625
Query: 607 GPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGW 666
GRC C+CD G+TG C + CR G C+ V C C G+
Sbjct: 626 HGRGRCEEG-----RCLCDPGYTGPTCATRM---CPADCRGRGRCVQGV----CLCHVGY 673
Query: 667 EGELC--DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNG 724
GE C + P P C R +L C C +G++G C + D C
Sbjct: 674 GGEDCGQEEPPASACPGGCGPR----ELCRAGQCVCVEGFRGPDCAIQTCPGD---CRGR 726
Query: 725 GTCYDSGDTFRCACPPGWKGSTC 747
G C+D C C G+ G C
Sbjct: 727 GECHDGS----CVCKDGYAGEDC 745
Score = 57.8 bits (138), Expect = 6e-08
Identities = 59/210 (28%), Positives = 73/210 (34%), Gaps = 51/210 (24%)
Query: 774 SCICRDGWEGRTCTHNTN-------------DCNPLPCYNGGICVDGVNWFRCECAPGFA 820
+C C GW G TC+ T+ C P C + G CV G RC C PG+
Sbjct: 155 TCSCEPGWGGPTCSDPTDAEIPPSSPPSASGSC-PDDCNDQGRCVRG----RCVCFPGYT 209
Query: 821 GPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFP 880
GP C C C CV + C C G +GP C + RSC P
Sbjct: 210 GPSC--GWPSCPGD-CQGRGRCVQGV----CVCRAGFSGPDCSQ-----RSC-------P 250
Query: 881 HGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLR 940
G S C RC+ C + G C + P C RC G+C+
Sbjct: 251 RGCSQRGRCEGGRCV-----CDPGYTG-DDCGMRSCPRG----CSQRGRC---ENGRCVC 297
Query: 941 PPCEAWGECGAEEPPSTPCLPRSGHLDNNC 970
P +CG P C R D C
Sbjct: 298 NPGYTGEDCGVRSCP-RGCSQRGRCKDGRC 326
Score = 36.6 bits (83), Expect = 0.15
Identities = 36/139 (25%), Positives = 51/139 (36%), Gaps = 31/139 (22%)
Query: 843 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCN-SCRCLDGRRDC 901
V +++ CSC PG GP C + + +P S +DCN RC+ GR C
Sbjct: 148 VFDLSRCTCSCEPGWGGPTCSDPTD---AEIPPSSPPSASGSCPDDCNDQGRCVRGRCVC 204
Query: 902 SKVW----CGWKPC----------------LLAG--QPEALSAQCPLGQRCLEKA---PG 936
+ CGW C AG P+ CP G C ++ G
Sbjct: 205 FPGYTGPSCGWPSCPGDCQGRGRCVQGVCVCRAGFSGPDCSQRSCPRG--CSQRGRCEGG 262
Query: 937 QCLRPPCEAWGECGAEEPP 955
+C+ P +CG P
Sbjct: 263 RCVCDPGYTGDDCGMRSCP 281
Score = 34.3 bits (77), Expect = 0.76
Identities = 23/75 (30%), Positives = 31/75 (41%), Gaps = 9/75 (12%)
Query: 204 SATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECR 263
++ C C PR C + G C++G+ G +C C C G C G C
Sbjct: 685 ASACPGGCGPRE------LC-RAGQCVCVEGFRGPDCAIQTCPGDCRG-RGECH-DGSCV 735
Query: 264 CSYGWQGRFCDECVP 278
C G+ G C E VP
Sbjct: 736 CKDGYAGEDCGEEVP 750
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 211 bits (536), Expect = 5e-54
Identities = 95/231 (41%), Positives = 128/231 (55%), Gaps = 12/231 (5%)
Query: 316 PCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHE---VPSGFECH 372
PC N GTC N + YRC CP GY GR+CE + +C+S PC NGG+CH + F C
Sbjct: 933 PCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCS 992
Query: 373 CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANEC--EGK 430
CP+G+ GPTC ++ D+C + CA GG CVD V + C CP Q+ G C+ + C +
Sbjct: 993 CPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLN 1052
Query: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRG-QCQHGGTCKDLVNGYQCVCPRG 489
PC + C G C+C+PG+ G NC N +DCR +CQ+G C D VN Y C+C G
Sbjct: 1053 PCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEG 1112
Query: 490 FGGRHCEL------ERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCE 534
+ G+ CE+ + C + C +G C D + C C GF GP CE
Sbjct: 1113 YSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Score = 181 bits (460), Expect = 3e-45
Identities = 87/241 (36%), Positives = 124/241 (51%), Gaps = 13/241 (5%)
Query: 638 DDCLGQPCRNGGTCI-DEVDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVND- 695
D CL PC+N GTC D ++ +RC CPSG++G C+ + + C PC + G C+ +
Sbjct: 927 DLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGED 986
Query: 696 --FYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNS 753
F C+C G++G TC C + C+NGG C D + C CP ++G C +
Sbjct: 987 APFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDL 1046
Query: 754 SCLP--NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWF 811
C P NPC + CVG+ C C G+ G C+ N +DC C NG C+D VN +
Sbjct: 1047 -CSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSY 1105
Query: 812 RCECAPGFAGPDCRINI------DECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQEV 865
C CA G++G C I C+ + C GA CVD+ N C C PG GP C+++
Sbjct: 1106 SCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEKL 1165
Query: 866 I 866
+
Sbjct: 1166 L 1166
Score = 173 bits (438), Expect = 1e-42
Identities = 83/234 (35%), Positives = 115/234 (49%), Gaps = 13/234 (5%)
Query: 351 CTSNPCANGGSCHEVP-SGFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDG--- 406
C S+PC N G+CH P + C CPSG+ G C + +D C+S PC GGTC Q
Sbjct: 929 CLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAP 988
Query: 407 FECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCR 466
F C CP + G TC ++ ++C C N C + +G Y C C ++G C V+ C
Sbjct: 989 FTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCS 1048
Query: 467 ---GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCH 523
CQH C +G +C C G+ G +C +D+C C +G C D + + C
Sbjct: 1049 PDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCL 1108
Query: 524 CPQGFSGPLCEVDVDL------CEPSPCRNGARCYNLEGDYYCACPDDFGGKNC 571
C +G+SG LCE+ L CE + C+NGA C + C C FGG C
Sbjct: 1109 CAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Score = 166 bits (420), Expect = 1e-40
Identities = 92/268 (34%), Positives = 131/268 (48%), Gaps = 32/268 (11%)
Query: 659 RCFCPSGWEGELCDTNPND------------------CLPDPCHSRGRCY-DLVNDFYCA 699
RC P EG+L T P CL PC ++G C+ D + + CA
Sbjct: 892 RCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCA 951
Query: 700 CDDGWKGKTCHSREFQCDAYTCSNGGTCY-DSGDT--FRCACPPGWKGSTCAVAKNSSCL 756
C G+KG+ C C + C NGGTC+ G+ F C+CP G++G TC V C+
Sbjct: 952 CPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGV-NTDDCV 1010
Query: 757 PNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNP--LPCYNGGICVDGVNWFRCE 814
+ C NGG CV +++C C +EG+ C + C+P PC + CV + RCE
Sbjct: 1011 DHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCE 1070
Query: 815 CAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPGRAGPRCQ---EVIGFGRS 871
C PG+AG +C N D+C+ C GA C+DE+N Y C C G +G C+ +
Sbjct: 1071 CMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSP 1130
Query: 872 CWSRGTPFPHGSSWVEDCNS--CRCLDG 897
C GT +G++ V+ N C+CL G
Sbjct: 1131 C--EGTECQNGANCVDQGNRPVCQCLPG 1156
Score = 166 bits (420), Expect = 1e-40
Identities = 87/278 (31%), Positives = 117/278 (42%), Gaps = 32/278 (11%)
Query: 517 ADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYY-CACPDDFGGKNCSVPR 575
A F C P + + DLC SPC+N C+N + Y CACP + G++C V
Sbjct: 909 AKKFECQGPPTLA---VQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSL 965
Query: 576 EPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 635
+ C G C C + G P F+C C +GF G C
Sbjct: 966 DSCSSGPCENGGTCHAQEGEDAP---------------------FTCSCPTGFEGPTCGV 1004
Query: 636 NIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCLPD--PCHSRGRCYDLV 693
N DDC+ C NGG C+D V + C CP +EG+ C+ + C PD PC +C
Sbjct: 1005 NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTP 1064
Query: 694 NDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAV---- 749
+ C C G+ G C + C + C NG C D +++ C C G+ G C +
Sbjct: 1065 DGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHL 1124
Query: 750 -AKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC 786
A S C C NG CV G C C G+ G C
Sbjct: 1125 PAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Score = 151 bits (381), Expect = 4e-36
Identities = 80/239 (33%), Positives = 108/239 (45%), Gaps = 16/239 (6%)
Query: 273 CDECVPYP----GCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEP 328
CD C+ P G H +E ++C C + + G C+ L+ C S PC NGGTC E
Sbjct: 926 CDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSS-GPCENGGTCHAQEG 984
Query: 329 DQ--YRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDI 386
+ + C+CP G+ G C C + CANGG C + + C CP + G C +
Sbjct: 985 EDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLV 1044
Query: 387 DECAS--NPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSCKNLIGG 444
D C+ NPC CV DG C C + G C + ++C C N C + +
Sbjct: 1045 DLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNS 1104
Query: 445 YYCDCIPGWKGINCHI------NVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCE 496
Y C C G+ G C I + C G +CQ+G C D N C C GFGG CE
Sbjct: 1105 YSCLCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Score = 149 bits (377), Expect = 1e-35
Identities = 89/277 (32%), Positives = 120/277 (43%), Gaps = 34/277 (12%)
Query: 369 FECHCPSGWSGPTCALDI--DECASNPCAAGGTCV-DQVDGFECICPEQWVGATCQLDAN 425
FEC P PT A+ D C S+PC GTC D ++ + C CP + G C++ +
Sbjct: 912 FECQGP-----PTLAVQAKCDLCLSSPCQNQGTCHNDPLEVYRCACPSGYKGRDCEVSLD 966
Query: 426 ECEGKPCLNAFSCKNLIGG---YYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNG 481
C PC N +C G + C C G++G C +N +DC C +GG C D V
Sbjct: 967 SCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGN 1026
Query: 482 YQCVCPRGFGGRHCELERDECAS--SPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDL 539
Y C CP + G+ CE D C+ +PC C DG C C G++G C + D
Sbjct: 1027 YTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDD 1086
Query: 540 CEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPRE-PCPGGACRVIDGCGSDAGPGMP 598
C C+NGA+C + Y C C + + G+ C +P P P C
Sbjct: 1087 CRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCE-------------- 1132
Query: 599 GTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHE 635
GT C CV Q G C C GF G C +
Sbjct: 1133 GTE----CQNGANCVDQ-GNRPVCQCLPGFGGPECEK 1164
Score = 134 bits (338), Expect = 4e-31
Identities = 67/217 (30%), Positives = 100/217 (46%), Gaps = 24/217 (11%)
Query: 262 CRCSYGWQGRFCDECVPYPGCVHGSCVE------------PWQCNCETNWGGLLCDKDLN 309
C C G++GR C+ V C G C P+ C+C T + G C + +
Sbjct: 950 CACPSGYKGRDCE--VSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTD 1007
Query: 310 YCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTS--NPCANGGSCHEVPS 367
C H C NGG C++ Y C CP Y G+ CE+ C+ NPC + C P
Sbjct: 1008 DC-VDHACANGGVCVDG-VGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPD 1065
Query: 368 GFECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQL----- 422
G C C G++G C+ + D+C + C G C+D+V+ + C+C E + G C++
Sbjct: 1066 GPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLP 1125
Query: 423 -DANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINC 458
+ CEG C N +C + C C+PG+ G C
Sbjct: 1126 APKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPEC 1162
Score = 70.9 bits (172), Expect = 7e-12
Identities = 51/169 (30%), Positives = 65/169 (38%), Gaps = 22/169 (13%)
Query: 282 CVHGSC----VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPD 337
C+HG C C+CE W GL CD+ + H C +G C+ + Y C C D
Sbjct: 1347 CLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHG-QCVPLDALSYSCQCQD 1405
Query: 338 GYSGRNCEKA---EHACTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC 394
GYSG C +A C C +G G C C G+SG C + EC +P
Sbjct: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SECRGDPV 1464
Query: 395 AAGGTCVDQVDGFECIC----PEQWVGATCQLDANECEGKPCLNAFSCK 439
QV IC P WV C+ C G+ C K
Sbjct: 1465 RD----FHQVQRGYAICQTTRPLSWV--ECR---GSCPGQGCCQGLRLK 1504
Score = 64.7 bits (156), Expect = 5e-10
Identities = 47/162 (29%), Positives = 58/162 (35%), Gaps = 11/162 (6%)
Query: 427 CEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINVND-CRG-QCQHGGTCKDLVNGYQC 484
C CL+ N G C C GW G++C + C G +C HG Y C
Sbjct: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
Query: 485 VCPRGFGGRHCELE---RDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCE 541
C G+ G C + C C G G HC C GFSG LCE + + C
Sbjct: 1402 QCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQESE-CR 1460
Query: 542 PSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGAC 583
P R+ + G C C R CPG C
Sbjct: 1461 GDPVRDFHQVQ--RGYAICQTTRPLSWVEC---RGSCPGQGC 1497
Score = 64.7 bits (156), Expect = 5e-10
Identities = 33/103 (32%), Positives = 42/103 (40%), Gaps = 4/103 (3%)
Query: 736 CACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN---TND 792
C C GW G C + C + CV+G S+SC C+DG+ G C
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEP 1421
Query: 793 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSP 835
C L C +G G C C PGF+G C EC+ P
Sbjct: 1422 CRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
Score = 63.9 bits (154), Expect = 9e-10
Identities = 55/188 (29%), Positives = 70/188 (37%), Gaps = 35/188 (18%)
Query: 240 CKEAVCKQGCNLLHGGC---TVPGE-CRCSYGWQGRFCDECVPYP----GCVHGSCVE-- 289
C++ C LHG C PG C C GW G CD+ P CVHG CV
Sbjct: 1342 CRKLYC------LHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLD 1395
Query: 290 --PWQCNCETNWGGLLCDKDLNYCGS-HHPCTN----GGTCINAEPDQYRCTCPDGYSGR 342
+ C C+ + G LC N G+ PC G C + C C G+SG
Sbjct: 1396 ALSYSCQCQDGYSGALC----NQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGE 1451
Query: 343 NCEKAEHACTSNPCANGGSCHEVPSGFE-CHCPSGWSGPTCALDIDECASNPCAAGGTCV 401
CE+ E C +P + H+V G+ C S C C C G
Sbjct: 1452 LCEQ-ESECRGDPVRD---FHQVQRGYAICQTTRPLSWVECR---GSCPGQGCCQGLRLK 1504
Query: 402 DQVDGFEC 409
+ FEC
Sbjct: 1505 RRKFTFEC 1512
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/125 (32%), Positives = 47/125 (37%), Gaps = 6/125 (4%)
Query: 387 DECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDAN-ECEGKPCLNAFSCKNLIGGY 445
+ C C G + G C C WVG C A+ C G C++ Y
Sbjct: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
Query: 446 YCDCIPGWKGINCH---INVNDCRG-QCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDE 501
C C G+ G C+ CRG QC HG G CVC GF G CE E E
Sbjct: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQE-SE 1458
Query: 502 CASSP 506
C P
Sbjct: 1459 CRGDP 1463
Score = 57.0 bits (136), Expect = 1e-07
Identities = 52/178 (29%), Positives = 68/178 (38%), Gaps = 30/178 (16%)
Query: 351 CTSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDECASNPC----AAGGTCVD-QVD 405
C C +G G CHC +GW G C D+ A PC G CV
Sbjct: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHC----DQPADGPCHGHKCVHGQCVPLDAL 1397
Query: 406 GFECICPEQWVGATCQLD---ANECEGKPCLNAFSCKNLIGGYYCDCIPGWKGINCHINV 462
+ C C + + GA C A C G CL+ + G +C C PG+ G C
Sbjct: 1398 SYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE-QE 1456
Query: 463 NDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD----ECASSPCHSGGLCEDL 516
++CRG D V + V RG+ C+ R EC S C G C+ L
Sbjct: 1457 SECRG---------DPVRDFHQV-QRGYA--ICQTTRPLSWVECRGS-CPGQGCCQGL 1501
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/150 (26%), Positives = 56/150 (37%), Gaps = 32/150 (21%)
Query: 540 CEPSP---CRNGARCYNLEGDYYCACPDDFGGKNCSVPRE-PCPGGACRVIDGCGSDAGP 595
CEP C +G N C C + G +C P + PC G C
Sbjct: 1339 CEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKC------------ 1386
Query: 596 GMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHEN---IDDCLGQPCRNGGTCI 652
HG+CV ++SC C G++G C++ + C G C +G
Sbjct: 1387 ------------VHGQCVPLDALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQA 1434
Query: 653 DEVDAFRCFCPSGWEGELCDTNPNDCLPDP 682
C C G+ GELC+ ++C DP
Sbjct: 1435 SGTKGAHCVCDPGFSGELCE-QESECRGDP 1463
Score = 52.0 bits (123), Expect = 4e-06
Identities = 36/109 (33%), Positives = 45/109 (41%), Gaps = 16/109 (14%)
Query: 660 CFCPSGWEGELCDTNPNDCLPDPCHSR----GRCYDL-VNDFYCACDDGWKGKTCHSREF 714
C C +GW G CD P D PCH G+C L + C C DG+ G C+
Sbjct: 1362 CHCEAGWVGLHCD-QPAD---GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGA 1417
Query: 715 ---QCDAYTCSNGGTCYDSGDT-FRCACPPGWKGSTCAVAKNSSCLPNP 759
C C +G C SG C C PG+ G C + S C +P
Sbjct: 1418 LAEPCRGLQCLHGH-CQASGTKGAHCVCDPGFSGELC--EQESECRGDP 1463
Score = 47.0 bits (110), Expect = 1e-04
Identities = 41/151 (27%), Positives = 60/151 (39%), Gaps = 28/151 (18%)
Query: 216 DFFGHYTCDQYGNKACMDGWMGKECKEAV--CKQGCNLLHGGCTVPG-----ECRCSYGW 268
D G+YTC C + GK C++ V C N G C C G+
Sbjct: 1022 DGVGNYTCQ------CPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDGPRCECMPGY 1075
Query: 269 QGRFC----DECVPYPGCVHGS-C---VEPWQCNCETNWGGLLCDKDLNYCGSHHPCT-- 318
G C D+C + C +G+ C V + C C + G LC+ + PC
Sbjct: 1076 AGDNCSENQDDCRDHR-CQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLPAPKSPCEGT 1134
Query: 319 ---NGGTCINAEPDQYRCTCPDGYSGRNCEK 346
NG C++ + ++ C C G+ G CEK
Sbjct: 1135 ECQNGANCVD-QGNRPVCQCLPGFGGPECEK 1164
Score = 40.0 bits (92), Expect = 0.014
Identities = 25/104 (24%), Positives = 33/104 (31%), Gaps = 3/104 (2%)
Query: 793 CNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINID-ECQSSPCAYGATCVDEINGYRC 851
C L C +G + C C G+ G C D C C +G + Y C
Sbjct: 1342 CRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSC 1401
Query: 852 SCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCL 895
C G +G C + C RG HG C+
Sbjct: 1402 QCQDGYSGALCNQAGALAEPC--RGLQCLHGHCQASGTKGAHCV 1443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.499
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,837,043
Number of Sequences: 37866
Number of extensions: 4030561
Number of successful extensions: 28312
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 307
Number of HSP's that attempted gapping in prelim test: 9701
Number of HSP's gapped (non-prelim): 5600
length of query: 1238
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1124
effective length of database: 13,930,794
effective search space: 15658212456
effective search space used: 15658212456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.