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Search of human proteins with 21686977
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21686977 cell adhesion molecule 4 [Homo sapiens]
(388 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21686977 cell adhesion molecule 4 [Homo sapiens] 780 0.0
gi|148664211 immunoglobulin superfamily, member 4D isoform 2 [Ho... 296 2e-80
gi|148664190 immunoglobulin superfamily, member 4D isoform 1 [Ho... 290 2e-78
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens] 236 3e-62
gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens] 232 4e-61
gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens] 227 1e-59
gi|166295173 kin of IRRE like [Homo sapiens] 104 1e-22
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 100 2e-21
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 100 2e-21
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 94 2e-19
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 94 2e-19
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 94 2e-19
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 84 2e-16
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 80 3e-15
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 80 4e-15
gi|42560237 poliovirus receptor-related 1 isoform 1 [Homo sapiens] 77 2e-14
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 77 3e-14
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 75 1e-13
gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens] 74 2e-13
gi|11386199 poliovirus receptor-related 3 [Homo sapiens] 73 4e-13
gi|59939900 opioid binding protein/cell adhesion molecule-like i... 72 8e-13
gi|4505505 opioid binding protein/cell adhesion molecule-like is... 72 8e-13
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 72 8e-13
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 72 8e-13
gi|112789532 poliovirus receptor related 2 isoform delta precurs... 71 1e-12
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 71 1e-12
gi|222136611 poliovirus receptor-related 4 [Homo sapiens] 71 2e-12
gi|119220552 sidekick 1 [Homo sapiens] 70 3e-12
gi|31543106 basal cell adhesion molecule isoform 1 precursor [Ho... 70 3e-12
gi|71274107 melanoma cell adhesion molecule [Homo sapiens] 70 4e-12
>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
Length = 388
Score = 780 bits (2013), Expect = 0.0
Identities = 388/388 (100%), Positives = 388/388 (100%)
Query: 1 MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPA 60
MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPA
Sbjct: 1 MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPA 60
Query: 61 RQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTV 120
RQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTV
Sbjct: 61 RQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTV 120
Query: 121 LVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSV 180
LVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSV
Sbjct: 121 LVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSV 180
Query: 181 ASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDT 240
ASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDT
Sbjct: 181 ASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDT 240
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA 300
LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA
Sbjct: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA 300
Query: 301 RALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEA 360
RALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEA
Sbjct: 301 RALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEA 360
Query: 361 SGLDEQGEAREAFLNGSDGHKRKEEFFI 388
SGLDEQGEAREAFLNGSDGHKRKEEFFI
Sbjct: 361 SGLDEQGEAREAFLNGSDGHKRKEEFFI 388
>gi|148664211 immunoglobulin superfamily, member 4D isoform 2 [Homo
sapiens]
Length = 414
Score = 296 bits (759), Expect = 2e-80
Identities = 158/388 (40%), Positives = 241/388 (62%), Gaps = 12/388 (3%)
Query: 11 LLLLWAAAA--GPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNG 68
LLLL++AAA G GQ + T++VTV EG VA I+C++++ D S++ + NP RQT++F
Sbjct: 29 LLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRD 88
Query: 69 TRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPV 128
R LKD RFQL FS +++ L++ + DEG YFCQLYT+ T+TVLV P N +
Sbjct: 89 FRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLM 148
Query: 129 VEV-REQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFR 187
+++ ++ AVEG E+E++C S+PA T+RW++ ELKG S +E +++V S + +
Sbjct: 149 IDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLK 208
Query: 188 VDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHAS---QAVVREGDTLVLT 244
V ++DDG +IC+ ++ A+ + QTQ L+VQY P I + Q + REGD L LT
Sbjct: 209 VHKEDDGVPVICQVEHPAVTG--NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELT 266
Query: 245 CAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALY 304
C G P+P + W R ++ +P+ A G L + L DNGTY CEASN G A + Y
Sbjct: 267 CEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDY 326
Query: 305 VLVVYDPGAVVEAQ-TSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGL 363
+L VYD A E +V +A++GG++A++VF ++C+L+ + R KG+Y THEA G
Sbjct: 327 MLYVYDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGA 386
Query: 364 DEQGEAREAFLN---GSDGHKRKEEFFI 388
D+ +A A +N G + + K+E+FI
Sbjct: 387 DDAADADTAIINAEGGQNNSEEKKEYFI 414
>gi|148664190 immunoglobulin superfamily, member 4D isoform 1 [Homo
sapiens]
Length = 442
Score = 290 bits (741), Expect = 2e-78
Identities = 158/416 (37%), Positives = 242/416 (58%), Gaps = 40/416 (9%)
Query: 11 LLLLWAAAA--GPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNG 68
LLLL++AAA G GQ + T++VTV EG VA I+C++++ D S++ + NP RQT++F
Sbjct: 29 LLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRD 88
Query: 69 TRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPV 128
R LKD RFQL FS +++ L++ + DEG YFCQLYT+ T+TVLV P N +
Sbjct: 89 FRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLM 148
Query: 129 VEV-REQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFR 187
+++ ++ AVEG E+E++C S+PA T+RW++ ELKG S +E +++V S + +
Sbjct: 149 IDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLK 208
Query: 188 VDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHAS---QAVVREGDTLVLT 244
V ++DDG +IC+ ++ A+ + QTQ L+VQY P I + Q + REGD L LT
Sbjct: 209 VHKEDDGVPVICQVEHPAVTG--NLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELT 266
Query: 245 CAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALY 304
C G P+P + W R ++ +P+ A G L + L DNGTY CEASN G A + Y
Sbjct: 267 CEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDY 326
Query: 305 VLVVYDPGAVVEAQT-----------------------------SVPYAIVGGILALLVF 335
+L VYDP + T +V +A++GG++A++VF
Sbjct: 327 MLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHAVIGGVVAVVVF 386
Query: 336 LIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLN---GSDGHKRKEEFFI 388
++C+L+ + R KG+Y THEA G D+ +A A +N G + + K+E+FI
Sbjct: 387 AMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI 442
>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
Length = 437
Score = 236 bits (602), Expect = 3e-62
Identities = 143/413 (34%), Positives = 217/413 (52%), Gaps = 49/413 (11%)
Query: 24 GQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFS 83
GQ T+NVTV EGG A +TCR+ Q D + + NPA+QTL+F+ +AL+D R +L S
Sbjct: 26 GQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRAS 85
Query: 84 PRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVE-VREQAVEGGEVE 142
+ I +SD L DEG Y C L+T A LTVL PE P + +EG ++
Sbjct: 86 WHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQ 145
Query: 143 LSCLVPRSRPAATLRWYRDRKELKGVSSSQE---NGKVWSVASTVRFRVDRKDDGGIIIC 199
L+C S+PAA +RW+++ KE+K V +E N K ++V+ST+ FRVDR DDG +IC
Sbjct: 146 LTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVIC 205
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWN 259
+++L + + VL++ Y+P+ +I S +EG L+LTC G P P + W
Sbjct: 206 RVDHESL-NATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWT 264
Query: 260 RGNESL--PERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD------P 311
+ L P+R G L + L DNGTY CEA+N G + A YVL+V+D P
Sbjct: 265 KDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLP 324
Query: 312 GAVVEAQTSV---------------------------------PYAIVGGILALLVFLII 338
++ + T+ +A++GGI+A++VF+ +
Sbjct: 325 TTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTL 384
Query: 339 CVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGH---KRKEEFFI 388
C + + R KG+YLT+EA G ++ +A A +N + K+E+FI
Sbjct: 385 CSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI 437
>gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens]
Length = 398
Score = 232 bits (592), Expect = 4e-61
Identities = 141/391 (36%), Positives = 212/391 (54%), Gaps = 16/391 (4%)
Query: 11 LLLLWAAAAGPGAGQEVQ------TENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTL 64
LLLL+A PG Q T + TV GG + C++ ++ S + NPA+QTL
Sbjct: 11 LLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTL 70
Query: 65 FFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAP 124
+F RAL+D R QL +P + I +S+ L DEG Y C ++T + +TVL P
Sbjct: 71 YFGEKRALRDNRIQLVTSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIP 130
Query: 125 ENPVVEVREQAV-EGGEVELSCLVPRSRPAATLRWYRDRKELKGVSS---SQENGKVWSV 180
+ P++ + ++ E L+C S+PAA L W + +EL G + NGK ++V
Sbjct: 131 QKPIITGYKSSLREKDTATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTV 190
Query: 181 ASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDT 240
+S+V F+V R+DDG I+C +++L G + T ++V Y+PTA I REG
Sbjct: 191 SSSVTFQVTREDDGASIVCSVNHESL-KGADRSTSQRIEVLYTPTAMIRPDPPHPREGQK 249
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA 300
L+L C GNP P Q W + S+P L P L +D+GTY C A++ G
Sbjct: 250 LLLHCEGRGNPVPQQYLWEK-EGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSY 308
Query: 301 RALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEA 360
+A Y L V DP + V + +S +AI+GGI+A +VFL++ +L+ + +R KG+YLTHEA
Sbjct: 309 KAYYTLNVNDP-SPVPSSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEA 367
Query: 361 SGLDEQGEAREAFLN---GSDGHKRKEEFFI 388
G D+ +A A +N G G K+E+FI
Sbjct: 368 KGSDDAPDADTAIINAEGGQSGGDDKKEYFI 398
>gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens]
Length = 432
Score = 227 bits (579), Expect = 1e-59
Identities = 136/375 (36%), Positives = 207/375 (55%), Gaps = 12/375 (3%)
Query: 23 AGQEVQ--TENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLE 80
A Q+ Q T + TV GG + C++ ++ S + NPA+QTL+F RAL+D R QL
Sbjct: 61 ASQDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRDNRIQLV 120
Query: 81 EFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAV-EGG 139
+P + I +S+ L DEG Y C ++T + +TVL P+ P++ + ++ E
Sbjct: 121 TSTPHELSISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKD 180
Query: 140 EVELSCLVPRSRPAATLRWYRDRKELKGVSS---SQENGKVWSVASTVRFRVDRKDDGGI 196
L+C S+PAA L W + +EL G + NGK ++V+S+V F+V R+DDG
Sbjct: 181 TATLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGAS 240
Query: 197 IICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQI 256
I+C +++L G + T ++V Y+PTA I REG L+L C GNP P Q
Sbjct: 241 IVCSVNHESL-KGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQY 299
Query: 257 RWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVE 316
W + S+P L P L +D+GTY C A++ G +A Y L V DP + V
Sbjct: 300 LWEK-EGSVPPLKMTQESALIFPFLNKSDSGTYGCTATSNMGSYKAYYTLNVNDP-SPVP 357
Query: 317 AQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLN- 375
+ +S +AI+GGI+A +VFL++ +L+ + +R KG+YLTHEA G D+ +A A +N
Sbjct: 358 SSSSTYHAIIGGIVAFIVFLLLIMLIFLGHYLIRHKGTYLTHEAKGSDDAPDADTAIINA 417
Query: 376 --GSDGHKRKEEFFI 388
G G K+E+FI
Sbjct: 418 EGGQSGGDDKKEYFI 432
>gi|166295173 kin of IRRE like [Homo sapiens]
Length = 757
Score = 104 bits (260), Expect = 1e-22
Identities = 93/328 (28%), Positives = 138/328 (42%), Gaps = 41/328 (12%)
Query: 12 LLLWAAAAGPGAGQEVQTE------NVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLF 65
LL+W Q QT + TV G A + C L Y G IV
Sbjct: 4 LLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGM 62
Query: 66 FNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPE 125
G +A R + + + ++DA L D+ Y CQ + A LTVL+ PE
Sbjct: 63 GQGLKAWPRYRV-VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPE 121
Query: 126 NPVVEVREQAVEGGEV---------ELSCLVPRSRPAATLRWYRDRKELKGVSSSQE--- 173
+ ++GG V L+C ++PAAT+ W+RD + +G +S E
Sbjct: 122 -------DTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLK 174
Query: 174 NGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQA 233
+GK + S + D G + C + N+A+PSG K+T LDV + PT +
Sbjct: 175 DGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSG--KETSIELDVHHPPTVTLSIEPQ 232
Query: 234 VVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYT--- 290
V+EG+ +V TC T NP RW +G + + E+ ET + D +T
Sbjct: 233 TVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYET-------NVDYSFFTEPV 285
Query: 291 -CEASNKHGHAR-ALYVLVVYDPGAVVE 316
CE NK G + V V + P VV+
Sbjct: 286 SCEVHNKVGSTNVSTLVNVHFAPRIVVD 313
Score = 41.2 bits (95), Expect = 0.002
Identities = 49/219 (22%), Positives = 80/219 (36%), Gaps = 31/219 (14%)
Query: 110 DTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVS 169
D HH T+T+ + P+ EG V +C + RW + ++
Sbjct: 218 DVHHP-PTVTLSIEPQT--------VQEGERVVFTCQATANPEILGYRWAKGGFLIEDAH 268
Query: 170 SSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIH 229
S+ VD + CE N+ S +++V ++P +
Sbjct: 269 ESR-----------YETNVDYSFFTEPVSCEVHNKV----GSTNVSTLVNVHFAPRIVVD 313
Query: 230 ASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTY 289
G + LTC GNP P + W + + ++ + L L + AD GTY
Sbjct: 314 PKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSNM---VLSNSNQLLLKSVTQADAGTY 369
Query: 290 TCEA-SNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVG 327
TC A + G A L V P + + +V YA+ G
Sbjct: 370 TCRAIVPRIGVAEREVPLYVNGPPII--SSEAVQYAVRG 406
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 100 bits (250), Expect = 2e-21
Identities = 93/316 (29%), Positives = 130/316 (41%), Gaps = 30/316 (9%)
Query: 11 LLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTR 70
LL + AGP Q E++ V G A + C L Y G + + L G R
Sbjct: 12 LLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLV----QWTKSGLALGGQR 67
Query: 71 ALKD-ERFQLEEFSPRRVR-IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPV 128
L R+ + + + + LEDE Y CQ + A L VLV PE P
Sbjct: 68 DLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP- 126
Query: 129 VEVREQAVEGGEVELSCLVPRS---------RPAATLRWYRDRKELKGVSSSQ---ENGK 176
Q + G V L VP + RP L W+RD L G + Q + G
Sbjct: 127 -----QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGT 181
Query: 177 VWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVR 236
SV ST+ DDG +C A++QALP+G + T L +QY P + AS V+
Sbjct: 182 PGSVESTLTLTPFSHDDGATFVCRARSQALPTG--RDTAITLSLQYPPEVTLSASPHTVQ 239
Query: 237 EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNK 296
EG+ ++ C T P RW +G + A G L + S +CE SN
Sbjct: 240 EGEKVIFLCQATAQPPVTGYRWAKGGSPV---LGARGPRLEVVADASFLTEPVSCEVSNA 296
Query: 297 HGHA-RALYVLVVYDP 311
G A R+ + V++ P
Sbjct: 297 VGSANRSTALDVLFGP 312
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/328 (24%), Positives = 118/328 (35%), Gaps = 41/328 (12%)
Query: 21 PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQ-- 78
P A Q + +V++ G A +TCR P + L+F L F
Sbjct: 123 PEAPQVLGGPSVSLVAGVPANLTCRSRGD-------ARPTPELLWFRDGVLLDGATFHQT 175
Query: 79 -LEEFSPRRVR--IRLSDARLEDEGGYFCQLYTE--DTHHQIA-TLTVLVAPENPVVEVR 132
L+E +P V + L+ +D + C+ ++ T A TL++ PE +
Sbjct: 176 LLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASP 235
Query: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
EG +V C P RW + + G G V + F +
Sbjct: 236 HTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGA-----RGPRLEVVADASFLTEP-- 288
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
+ CE N + S LDV + P + V G+ +CA GNP
Sbjct: 289 ----VSCEVSNAVGSANRST----ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPL 340
Query: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA----SNKHGHARALYVLVV 308
P ++ W R + + G TL LP + D G Y C A S G A + V
Sbjct: 341 P-RVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN 396
Query: 309 YDPGAVVEAQTSVPYAIVG-GILALLVF 335
P VV A S P + G L LVF
Sbjct: 397 APP--VVTALHSAPAFLRGPARLQCLVF 422
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 100 bits (250), Expect = 2e-21
Identities = 93/316 (29%), Positives = 130/316 (41%), Gaps = 30/316 (9%)
Query: 11 LLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTR 70
LL + AGP Q E++ V G A + C L Y G + + L G R
Sbjct: 12 LLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLV----QWTKSGLALGGQR 67
Query: 71 ALKD-ERFQLEEFSPRRVR-IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPV 128
L R+ + + + + LEDE Y CQ + A L VLV PE P
Sbjct: 68 DLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP- 126
Query: 129 VEVREQAVEGGEVELSCLVPRS---------RPAATLRWYRDRKELKGVSSSQ---ENGK 176
Q + G V L VP + RP L W+RD L G + Q + G
Sbjct: 127 -----QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGT 181
Query: 177 VWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVR 236
SV ST+ DDG +C A++QALP+G + T L +QY P + AS V+
Sbjct: 182 PGSVESTLTLTPFSHDDGATFVCRARSQALPTG--RDTAITLSLQYPPEVTLSASPHTVQ 239
Query: 237 EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNK 296
EG+ ++ C T P RW +G + A G L + S +CE SN
Sbjct: 240 EGEKVIFLCQATAQPPVTGYRWAKGGSPV---LGARGPRLEVVADASFLTEPVSCEVSNA 296
Query: 297 HGHA-RALYVLVVYDP 311
G A R+ + V++ P
Sbjct: 297 VGSANRSTALDVLFGP 312
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/328 (24%), Positives = 118/328 (35%), Gaps = 41/328 (12%)
Query: 21 PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQ-- 78
P A Q + +V++ G A +TCR P + L+F L F
Sbjct: 123 PEAPQVLGGPSVSLVAGVPANLTCRSRGD-------ARPTPELLWFRDGVLLDGATFHQT 175
Query: 79 -LEEFSPRRVR--IRLSDARLEDEGGYFCQLYTE--DTHHQIA-TLTVLVAPENPVVEVR 132
L+E +P V + L+ +D + C+ ++ T A TL++ PE +
Sbjct: 176 LLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASP 235
Query: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
EG +V C P RW + + G G V + F +
Sbjct: 236 HTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGA-----RGPRLEVVADASFLTEP-- 288
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
+ CE N + S LDV + P + V G+ +CA GNP
Sbjct: 289 ----VSCEVSNAVGSANRST----ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPL 340
Query: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA----SNKHGHARALYVLVV 308
P ++ W R + + G TL LP + D G Y C A S G A + V
Sbjct: 341 P-RVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN 396
Query: 309 YDPGAVVEAQTSVPYAIVG-GILALLVF 335
P VV A S P + G L LVF
Sbjct: 397 APP--VVTALHSAPAFLRGPARLQCLVF 422
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 94.4 bits (233), Expect = 2e-19
Identities = 74/300 (24%), Positives = 132/300 (44%), Gaps = 17/300 (5%)
Query: 28 QTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV 87
Q ++ V G + C + +YDG ++ I++ L + + +
Sbjct: 53 QPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGL--ALGVGRDLSSYPQYLVVGNHLSGEH 110
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVV----EVREQAVEGGEVEL 143
+++ A L+D+ Y CQ + A LTVLV P++PV+ + +A G + L
Sbjct: 111 HLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA--GDPLNL 168
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQ---ENGKVWSVASTVRFRVDRKDDGGIIICE 200
+C ++PAA++ W R + + G + S+ +GK S+ ST+ ++G I+C
Sbjct: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
Query: 201 AQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
A N+A+P G K+T +D+Q+ P + V E + + C+ NP Q RW +
Sbjct: 229 ATNKAIPGG--KETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAK 286
Query: 261 GNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVY-DPGAVVEAQT 319
+ + EA GE + + +CE +N G + VY P E Q+
Sbjct: 287 RGQII---KEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQS 343
Score = 41.6 bits (96), Expect = 0.001
Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 20/188 (10%)
Query: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
+ +E V C + RW + +G + +G+V+ R VD
Sbjct: 259 QPVLEDNVVTFHCSAKANPAVTQYRWAK-----RGQIIKEASGEVY------RTTVDYTY 307
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
+ CE N AL S + +T +DV + P +V G + +CA TGNP
Sbjct: 308 FSEPVSCEVTN-ALGSTNLSRT---VDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPS 363
Query: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA-SNKHGHARALYVLVVYDP 311
+ RG+ + +TLTL + D G Y C A + G L V P
Sbjct: 364 LTIVWMKRGSGVVLSNE----KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP 419
Query: 312 GAVVEAQT 319
+ QT
Sbjct: 420 PIISSTQT 427
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 94.4 bits (233), Expect = 2e-19
Identities = 74/300 (24%), Positives = 132/300 (44%), Gaps = 17/300 (5%)
Query: 28 QTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV 87
Q ++ V G + C + +YDG ++ I++ L + + +
Sbjct: 53 QPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGL--ALGVGRDLSSYPQYLVVGNHLSGEH 110
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVV----EVREQAVEGGEVEL 143
+++ A L+D+ Y CQ + A LTVLV P++PV+ + +A G + L
Sbjct: 111 HLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA--GDPLNL 168
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQ---ENGKVWSVASTVRFRVDRKDDGGIIICE 200
+C ++PAA++ W R + + G + S+ +GK S+ ST+ ++G I+C
Sbjct: 169 TCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCR 228
Query: 201 AQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
A N+A+P G K+T +D+Q+ P + V E + + C+ NP Q RW +
Sbjct: 229 ATNKAIPGG--KETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAK 286
Query: 261 GNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVY-DPGAVVEAQT 319
+ + EA GE + + +CE +N G + VY P E Q+
Sbjct: 287 RGQII---KEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQS 343
Score = 41.6 bits (96), Expect = 0.001
Identities = 46/188 (24%), Positives = 70/188 (37%), Gaps = 20/188 (10%)
Query: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
+ +E V C + RW + +G + +G+V+ R VD
Sbjct: 259 QPVLEDNVVTFHCSAKANPAVTQYRWAK-----RGQIIKEASGEVY------RTTVDYTY 307
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
+ CE N AL S + +T +DV + P +V G + +CA TGNP
Sbjct: 308 FSEPVSCEVTN-ALGSTNLSRT---VDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPS 363
Query: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA-SNKHGHARALYVLVVYDP 311
+ RG+ + +TLTL + D G Y C A + G L V P
Sbjct: 364 LTIVWMKRGSGVVLSNE----KTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGP 419
Query: 312 GAVVEAQT 319
+ QT
Sbjct: 420 PIISSTQT 427
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 94.4 bits (233), Expect = 2e-19
Identities = 74/236 (31%), Positives = 102/236 (43%), Gaps = 24/236 (10%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVP 148
+ + LEDE Y CQ + A L VLV PE P Q + G V L VP
Sbjct: 38 LHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP------QVLGGPSVSLVAGVP 91
Query: 149 RS---------RPAATLRWYRDRKELKGVSSSQ---ENGKVWSVASTVRFRVDRKDDGGI 196
+ RP L W+RD L G + Q + G SV ST+ DDG
Sbjct: 92 ANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGAT 151
Query: 197 IICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQI 256
+C A++QALP+G + T L +QY P + AS V+EG+ ++ C T P
Sbjct: 152 FVCRARSQALPTG--RDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGY 209
Query: 257 RWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA-RALYVLVVYDP 311
RW +G + A G L + S +CE SN G A R+ + V++ P
Sbjct: 210 RWAKGGSPV---LGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGP 262
Score = 50.4 bits (119), Expect = 3e-06
Identities = 81/328 (24%), Positives = 118/328 (35%), Gaps = 41/328 (12%)
Query: 21 PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQ-- 78
P A Q + +V++ G A +TCR P + L+F L F
Sbjct: 73 PEAPQVLGGPSVSLVAGVPANLTCRSRGD-------ARPTPELLWFRDGVLLDGATFHQT 125
Query: 79 -LEEFSPRRVR--IRLSDARLEDEGGYFCQLYTE--DTHHQIA-TLTVLVAPENPVVEVR 132
L+E +P V + L+ +D + C+ ++ T A TL++ PE +
Sbjct: 126 LLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASP 185
Query: 133 EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD 192
EG +V C P RW + + G G V + F +
Sbjct: 186 HTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGA-----RGPRLEVVADASFLTEP-- 238
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPR 252
+ CE N + S LDV + P + V G+ +CA GNP
Sbjct: 239 ----VSCEVSNAVGSANRST----ALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPL 290
Query: 253 PNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEA----SNKHGHARALYVLVV 308
P ++ W R + + G TL LP + D G Y C A S G A + V
Sbjct: 291 P-RVTWTRRGGA---QVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVN 346
Query: 309 YDPGAVVEAQTSVPYAIVG-GILALLVF 335
P VV A S P + G L LVF
Sbjct: 347 APP--VVTALHSAPAFLRGPARLQCLVF 372
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 84.3 bits (207), Expect = 2e-16
Identities = 72/240 (30%), Positives = 101/240 (42%), Gaps = 20/240 (8%)
Query: 89 IRLSDARLEDEGGYFC----QLYTEDTHHQIATLTVLVAPENPVVEVREQ--AVEGGEVE 142
+++S A+ D G Y C L T ++ T +AP P V+ E VE G
Sbjct: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTA 3229
Query: 143 LSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQ 202
PA T+ W + R L + T+ + D G IC A
Sbjct: 3230 TLRCSATGSPAPTIHWSKLRSPLPWQHRLE--------GDTLIIPRVAQQDSGQYICNAT 3281
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
+ P+GH++ T +L V+ P A A V+ G+T+ L C G P P +W+R
Sbjct: 3282 S---PAGHAEAT-IILHVESPPYATTVPEHASVQAGETVQLQCLAHGTP-PLTFQWSRVG 3336
Query: 263 ESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVP 322
SLP RA A E L D+G Y C +NK G A A L+V P + A TS+P
Sbjct: 3337 SSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPA-TSIP 3395
Score = 82.0 bits (201), Expect = 8e-16
Identities = 87/320 (27%), Positives = 133/320 (41%), Gaps = 39/320 (12%)
Query: 17 AAAGPGAGQEVQ-TENVTVAEGGVAEITCRLHQYDGSIVVIQ---NPARQTLFFNGTRAL 72
AA+GPG QE T V +EG + + D +Q + + + L +G +
Sbjct: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPI 3052
Query: 73 ----KDERFQLEE---FSPRRVRIRLSDARLEDEGGYFC---------QLYTEDTHHQIA 116
K +LE+ SP I + R + G Y C Q + H
Sbjct: 3053 SLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPP 3112
Query: 117 TLTVLVAPENPV-VEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENG 175
T++VL PE PV V+V G V L C V P ++ RW R Q
Sbjct: 3113 TVSVL--PEGPVWVKV------GKAVTLEC-VSAGEPRSSARWTRISST--PAKLEQRTY 3161
Query: 176 KVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQY----SPTARIHAS 231
+ + ++ + D G +C AQN AL + KQ + ++D +P + +
Sbjct: 3162 GLMDSHAVLQISSAKPSDAGTYVCLAQN-ALGTAQ-KQVEVIVDTGAMAPGAPQVQAEEA 3219
Query: 232 QAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTC 291
+ V G T L C+ TG+P P I W++ LP + G+TL +P + D+G Y C
Sbjct: 3220 ELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYIC 3278
Query: 292 EASNKHGHARALYVLVVYDP 311
A++ GHA A +L V P
Sbjct: 3279 NATSPAGHAEATIILHVESP 3298
Score = 71.2 bits (173), Expect = 1e-12
Identities = 64/225 (28%), Positives = 85/225 (37%), Gaps = 20/225 (8%)
Query: 98 DEGGYFC---QLYTEDTHHQIATLTVLVAPENPVV----EVREQAVE-GGEVELSCLVPR 149
D G Y C L+ +T A L V AP P+ E R Q+V G +V C
Sbjct: 1740 DAGVYICTCRNLHQSNTSR--AELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKS 1797
Query: 150 SRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ-ALPS 208
PA TL W R + NG + R + D G +C N A+
Sbjct: 1798 KSPAYTLVWTRLHNGKLPTRAMDFNG-------ILTIRNVQLSDAGTYVCTGSNMFAMDQ 1850
Query: 209 GHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRG-NESLPE 267
G + +P IH Q V+ G C+ TG+P P + W G LP
Sbjct: 1851 GTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPT-LEWTGGPGGQLPA 1909
Query: 268 RAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPG 312
+A+ G L LP + D Y C A + G A VL V+ G
Sbjct: 1910 KAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGG 1954
Score = 71.2 bits (173), Expect = 1e-12
Identities = 78/308 (25%), Positives = 124/308 (40%), Gaps = 48/308 (15%)
Query: 20 GPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQL 79
GP +++ + TVAEG +++C +V Q A+ T + G R Q+
Sbjct: 2242 GPIPPVRIESSSSTVAEGQTLDLSC--------VVAGQAHAQVTWYKRG--GSLPARHQV 2291
Query: 80 EEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVA---------PENPVVE 130
R R+ + A D G Y C+ ++ A++TV V P
Sbjct: 2292 -----RGSRLYIFQASPADAGQYVCRA----SNGMEASITVTVTGTQGANLAYPAGSTQP 2342
Query: 131 VR-----EQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVR 185
+R Q EG ++L+C+VP + A + W++ L Q +G S +R
Sbjct: 2343 IRIEPSSSQVAEGQTLDLNCVVP-GQSHAQVTWHKRGGSLP--VRHQTHG------SLLR 2393
Query: 186 FRVDRKDDGGIIICEAQNQALPSGHS-----KQTQYVLDVQYSPTARIHASQAVVREGDT 240
D G +C ++P S + V + +PT RI +S + V EG T
Sbjct: 2394 LYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQT 2453
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA 300
L L C V G Q+ W++ SLP R + G L L + AD+G Y C G
Sbjct: 2454 LDLNCLVAGQAHA-QVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQ 2512
Query: 301 RALYVLVV 308
A ++ +
Sbjct: 2513 EASVLVTI 2520
Score = 69.7 bits (169), Expect = 4e-12
Identities = 65/242 (26%), Positives = 96/242 (39%), Gaps = 19/242 (7%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLV----APENPVVEVREQAVEGGEVELS 144
+RL D+ Y C+ ++ Q+A + V P V R Q G V L
Sbjct: 1918 LRLPAVEPTDQAQYLCRAHSS-AGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLY 1976
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ 204
C P+AT+ W ++ L + S+ +T+ D G +C A +
Sbjct: 1977 CRAA-GVPSATITWRKEGGSLPPQARSERTD-----IATLLIPAITTADAGFYLCVATS- 2029
Query: 205 ALPSGHSKQTQYVLDVQYS----PTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
P+G ++ V+ + S P +I +S V EG TL L C V G+ Q+ W R
Sbjct: 2030 --PAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA-QVTWYR 2086
Query: 261 GNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
SLP + G L LP + AD+G Y C N G A + V + T
Sbjct: 2087 RGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTP 2146
Query: 321 VP 322
VP
Sbjct: 2147 VP 2148
Score = 68.9 bits (167), Expect = 7e-12
Identities = 65/261 (24%), Positives = 97/261 (37%), Gaps = 42/261 (16%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVL----------VAPENPVVEVREQAVEG 138
+RL A D G Y C++ + + L + V P + Q EG
Sbjct: 2392 LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEG 2451
Query: 139 GEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIII 198
++L+CLV + A + W++ L + Q +G S +R D G +
Sbjct: 2452 QTLDLNCLVA-GQAHAQVTWHKRGGSLP--ARHQVHG------SRLRLLQVTPADSGEYV 2502
Query: 199 CEAQN--------------QALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLT 244
C Q L HS+ Y + RI +S A + G TL L
Sbjct: 2503 CRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPV--------RIESSSASLANGHTLDLN 2554
Query: 245 CAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALY 304
C V P+ I W + SLP R + VG L +P + AD+G Y C SN G
Sbjct: 2555 CLVASQA-PHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSL 2613
Query: 305 VLVVYDPGAVVEAQTSVPYAI 325
++ + G+ S P I
Sbjct: 2614 IVTIQGSGSSHVPSVSPPIRI 2634
Score = 68.6 bits (166), Expect = 9e-12
Identities = 64/241 (26%), Positives = 92/241 (38%), Gaps = 34/241 (14%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVL-----------VAPENPVVEVREQAV 136
R+RL D G Y C++ + + L + VA +
Sbjct: 2487 RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLA 2546
Query: 137 EGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGI 196
G ++L+CLV P T+ WY+ L + V S +R D G
Sbjct: 2547 NGHTLDLNCLVASQAPH-TITWYKRGGSLPS--------RHQIVGSRLRIPQVTPADSGE 2597
Query: 197 IICEAQNQALPSGHSKQTQYVLDVQ---------YSPTARIHASQAVVREGDTLVLTCAV 247
+C N A S++T ++ +Q SP RI +S V EG TL L C V
Sbjct: 2598 YVCHVSNGA----GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVV 2653
Query: 248 TGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLV 307
P+ I W + SLP R + G L L + AD+G Y C A+N A V+
Sbjct: 2654 ARQPQA-IITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVIS 2712
Query: 308 V 308
V
Sbjct: 2713 V 2713
Score = 65.9 bits (159), Expect = 6e-11
Identities = 59/247 (23%), Positives = 100/247 (40%), Gaps = 31/247 (12%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENP-------------VVEVREQA 135
+RL+ D G Y CQ+ T + A++ V + P +P +
Sbjct: 2878 LRLNQVSPADSGEYSCQV-TGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV 2936
Query: 136 VEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGG 195
EG ++L+C+VP + A + WY+ L + Q +G S +R + D G
Sbjct: 2937 TEGQTLDLNCVVP-GQAHAQVTWYKRGGSLP--ARHQTHG------SQLRLHLVSPADSG 2987
Query: 196 IIICEAQNQALPSGHSKQTQYVLDVQ------YSPTARIHASQAVVREGDTLVLTCAVTG 249
+C A + P + T V + SP I + V++G C +
Sbjct: 2988 EYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHD 3047
Query: 250 NPRPNQIRWNRGNESLPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLV 307
P + W N+ L + G +T+ G +++GTY C ASN +G A+++ L
Sbjct: 3048 GAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLS 3107
Query: 308 VYDPGAV 314
V+ P V
Sbjct: 3108 VHGPPTV 3114
Score = 65.9 bits (159), Expect = 6e-11
Identities = 68/243 (27%), Positives = 100/243 (41%), Gaps = 24/243 (9%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVR---EQAVEGGEVELSC 145
+R+ + +G Y CQ + Q + V+ A + ++ +R + V G VE C
Sbjct: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC 3510
Query: 146 LVPRSRPAATLRWYRDRKELK-GVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ 204
L P + W + L+ G+ S VR D G C A N
Sbjct: 3511 LA-LGDPKPQVTWSKVGGHLRPGIVQS---------GGVVRIAHVELADAGQYRCTATNA 3560
Query: 205 ALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNPRPNQIRWNRGNE 263
A + Q+ +L VQ P +I Q V V G V C +G P P+ I W++ +
Sbjct: 3561 A----GTTQSHVLLLVQALP--QISMPQEVRVPAGSAAVFPCIASGYPTPD-ISWSKLDG 3613
Query: 264 SLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPY 323
SLP + L LP + D GTY C A+N+ G +A L V P VV T PY
Sbjct: 3614 SLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV--PERVVPYFTQTPY 3671
Query: 324 AIV 326
+ +
Sbjct: 3672 SFL 3674
Score = 62.0 bits (149), Expect = 9e-10
Identities = 70/308 (22%), Positives = 116/308 (37%), Gaps = 48/308 (15%)
Query: 27 VQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRR 86
+++ + TV EG ++ C VV + P ++ +L
Sbjct: 2634 IESSSPTVVEGQTLDLNC---------VVARQPQAIITWYKRGGSLPSRH------QTHG 2678
Query: 87 VRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPE--NP----------VVEVREQ 134
+RL + D G Y C+ + A++ + V+P +P +
Sbjct: 2679 SHLRLHQMSVADSGEYVCRA-NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 2737
Query: 135 AVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDG 194
EG ++L+C+VP + A + W++ L S Q G S +R D
Sbjct: 2738 VAEGETLDLNCVVP-GQAHAQVTWHKRGGSLP--SHHQTRG------SRLRLHHVSPADS 2788
Query: 195 GIIICEAQNQALP---------SGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTC 245
G +C + P +V +P RI S + V EG TL L C
Sbjct: 2789 GEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKC 2848
Query: 246 AVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYV 305
V G Q+ W++ +LP R + G L L + AD+G Y+C+ + G A V
Sbjct: 2849 VVPGQAHA-QVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEA-SV 2906
Query: 306 LVVYDPGA 313
LV +P +
Sbjct: 2907 LVTIEPSS 2914
Score = 61.2 bits (147), Expect = 2e-09
Identities = 62/227 (27%), Positives = 89/227 (39%), Gaps = 26/227 (11%)
Query: 98 DEGGYFCQLY----TEDTHHQIATLTVLVAPENPV-VEVREQAV-EGGEVELSCLVPRSR 151
D G Y C T Q+ L+ A PV +E +V EG ++L+C+V S
Sbjct: 2019 DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSA 2078
Query: 152 PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHS 211
A + WYR L +Q +G S +R D G +C +N + P S
Sbjct: 2079 HAQ-VTWYRRGGSLP--PHTQVHG------SRLRLPQVSPADSGEYVCRVENGSGPKEAS 2129
Query: 212 KQTQYVLDVQYSPT----------ARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRG 261
+ P+ RI S + V EG TL L C V G Q+ W++
Sbjct: 2130 ITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHA-QVTWHKR 2188
Query: 262 NESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
SLP R + G L L + AD+G Y C G A ++ +
Sbjct: 2189 GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
Score = 59.7 bits (143), Expect = 4e-09
Identities = 57/245 (23%), Positives = 92/245 (37%), Gaps = 26/245 (10%)
Query: 97 EDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGE-VELSCLVPRSRPAAT 155
+D G Y C + H + + + +P +V+ GE V+L CL P T
Sbjct: 3271 QDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLA-HGTPPLT 3329
Query: 156 LRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQAL--------- 206
+W R L G ++++ + F +D G C N+
Sbjct: 3330 FQWSRVGSSLPGRATARNE--------LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLL 3381
Query: 207 ---PSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNE 263
P G T + +PT ++ G ++ CAV + R Q+RW +
Sbjct: 3382 VQGPPGSLPATS--IPAGSTPTVQVTPQLETKSIGASVEFHCAVPSD-RGTQLRWFKEGG 3438
Query: 264 SLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD-PGAVVEAQTSVP 322
LP L + L + GTY C+A G A+A LV+ P ++ +TSV
Sbjct: 3439 QLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ 3498
Query: 323 YAIVG 327
+VG
Sbjct: 3499 TVVVG 3503
Score = 58.9 bits (141), Expect = 7e-09
Identities = 66/248 (26%), Positives = 101/248 (40%), Gaps = 39/248 (15%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLV--------------APENPV-VEVR 132
R+RL D G Y C++ + A++TV V P+ +E
Sbjct: 2101 RLRLPQVSPADSGEYVCRVENGSGPKE-ASITVSVLHGTHSGPSYTPVPGSTRPIRIEPS 2159
Query: 133 EQAV-EGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRK 191
V EG ++L+C+VP + A + W++ L + Q +G S +R
Sbjct: 2160 SSHVAEGQTLDLNCVVP-GQAHAQVTWHKRGGSLP--ARHQTHG------SLLRLHQVTP 2210
Query: 192 DDGGIIICEAQNQALPSGHSKQTQYVLDVQYS------PTARIHASQAVVREGDTLVLTC 245
D G +C + P + ++ ++ S P RI +S + V EG TL L+C
Sbjct: 2211 ADSGEYVCHVVGTSGPL----EASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC 2266
Query: 246 AVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYV 305
V G Q+ W + SLP R + G L + AD G Y C ASN G ++ V
Sbjct: 2267 VVAGQAHA-QVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEASITV 2323
Query: 306 LVVYDPGA 313
V GA
Sbjct: 2324 TVTGTQGA 2331
Score = 58.2 bits (139), Expect = 1e-08
Identities = 63/252 (25%), Positives = 98/252 (38%), Gaps = 30/252 (11%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAP--------ENPVVEV---REQAV 136
++RL D G Y C+ + Q A+ TV V P +PV+ +
Sbjct: 2975 QLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQ 3034
Query: 137 EGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGI 196
+G + CL+ +L W +EL+ NG + ++ T R + G
Sbjct: 3035 QGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGT------RPSNHGT 3088
Query: 197 IICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNPRPNQ 255
C A N + Q+ L V PT + V V+ G + L C G PR +
Sbjct: 3089 YRCVASN----AYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPR-SS 3143
Query: 256 IRWNRGNES---LPERAEAVGET---LTLPGLVSADNGTYTCEASNKHGHARALYVLVVY 309
RW R + + L +R + ++ L + +D GTY C A N G A+ V V+
Sbjct: 3144 ARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK-QVEVIV 3202
Query: 310 DPGAVVEAQTSV 321
D GA+ V
Sbjct: 3203 DTGAMAPGAPQV 3214
Score = 56.2 bits (134), Expect = 5e-08
Identities = 63/246 (25%), Positives = 90/246 (36%), Gaps = 23/246 (9%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAP--ENPVVEVREQA-----VEGGEV 141
+RL D G Y C + + + L + A P+ VR ++ EG +
Sbjct: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTL 2262
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEA 201
+LSC+V + A + WY+ L + + AS D G +C A
Sbjct: 2263 DLSCVVA-GQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPA--------DAGQYVCRA 2313
Query: 202 QNQALPS-----GHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQI 256
N S ++ + RI S + V EG TL L C V G Q+
Sbjct: 2314 SNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHA-QV 2372
Query: 257 RWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVE 316
W++ SLP R + G L L AD+G Y C A VLV +P V
Sbjct: 2373 TWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEA-SVLVTIEPAGSVP 2431
Query: 317 AQTSVP 322
A P
Sbjct: 2432 ALGVTP 2437
Score = 45.8 bits (107), Expect = 7e-05
Identities = 55/210 (26%), Positives = 77/210 (36%), Gaps = 18/210 (8%)
Query: 116 ATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENG 175
A L V V P +V +GG L C V S P +Y R++ + V S +
Sbjct: 1675 APLVVEVHPARSIVP------QGGSHSLRCQVSGSPPHY---FYWSREDGRPVPSGTQQR 1725
Query: 176 KVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSP---TARIHASQ 232
S + F + D G+ IC +N S S+ V + P T SQ
Sbjct: 1726 HQ---GSELHFPSVQPSDAGVYICTCRNLH-QSNTSRAELLVTEAPSKPITVTVEEQRSQ 1781
Query: 233 AVVREGDTLVLTCAVTGNPRPNQIRWNR-GNESLPERAEAVGETLTLPGLVSADNGTYTC 291
+V R G + C + W R N LP RA LT+ + +D GTY C
Sbjct: 1782 SV-RPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVC 1840
Query: 292 EASNKHGHARALYVLVVYDPGAVVEAQTSV 321
SN + L V G + S+
Sbjct: 1841 TGSNMFAMDQGTATLHVQASGTLSAPVVSI 1870
Score = 36.6 bits (83), Expect = 0.040
Identities = 26/81 (32%), Positives = 33/81 (40%), Gaps = 12/81 (14%)
Query: 224 PTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPER------AEAVGETLT 277
P I AS+ G T+ TC G P P I W +P +E TL
Sbjct: 412 PRESIQASR-----GQTVTFTCVAIGVPTPI-INWRLNWGHIPSHPRVTVTSEGGRGTLI 465
Query: 278 LPGLVSADNGTYTCEASNKHG 298
+ + +D G YTCEA N G
Sbjct: 466 IRDVKESDQGAYTCEAMNARG 486
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 80.1 bits (196), Expect = 3e-15
Identities = 80/246 (32%), Positives = 106/246 (43%), Gaps = 29/246 (11%)
Query: 79 LEEFSPRRVRIRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQAVE 137
L+ F RV + L+ AR D G Y C + Q L V + P E+ V
Sbjct: 2026 LQVFPGGRV-LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVA 2084
Query: 138 GGEVELSCLVPRSRPAATLRWYRDRKELK---GVSSSQENGKVWSVASTVRFRVDRKD-- 192
V L C + P L W++D + L+ GV S A +VDR D
Sbjct: 2085 NESVALECQ-SHAMPPPVLSWWKDGRPLEPRPGVHLS---------ADKALLQVDRADVW 2134
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNP 251
D G CEA NQA GHS++ Y L+V +P + S + VREG L+C G P
Sbjct: 2135 DAGHYTCEALNQA---GHSEK-HYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP 2190
Query: 252 RPNQIRWNRGNESLP------ERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYV 305
P +I W + + LP + AVG L L A GTYTCE SN G++
Sbjct: 2191 FP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 2249
Query: 306 LVVYDP 311
L V+ P
Sbjct: 2250 LEVHVP 2255
Score = 73.6 bits (179), Expect = 3e-13
Identities = 68/221 (30%), Positives = 101/221 (45%), Gaps = 24/221 (10%)
Query: 97 EDEGGYFCQLYTEDTHHQIATLTVLVAPENPVV--EVREQAVE--GGEVELSCLVPRSRP 152
ED G Y C + E+ + ++ + E PV+ E VE GG ++L C+V R P
Sbjct: 4190 EDSGTYVC--WAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDP 4246
Query: 153 AATLRWYRDRKELKG--VSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGH 210
+ W +D L+G + +NG S R +R DD G C A+N+ G
Sbjct: 4247 VPDIHWIKDGLPLRGSHLRHQLQNG------SLTIHRTER-DDAGRYQCLAENEM---GV 4296
Query: 211 SKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL--PER 268
+K+ +L +Q +P ++ VR GD + L C TG P P I W + + L R
Sbjct: 4297 AKKV-VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT-IEWLQAGQPLRASRR 4354
Query: 269 AEAVGE-TLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
+ + +L L + + D GTY C A N G A A LVV
Sbjct: 4355 LRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 4395
Score = 70.1 bits (170), Expect = 3e-12
Identities = 63/250 (25%), Positives = 103/250 (41%), Gaps = 12/250 (4%)
Query: 89 IRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVRE-QAVEGGEVELSCL 146
+++S A + D Y C + + ++ TL V V P +++ + A+ V L C
Sbjct: 2901 LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCD 2960
Query: 147 VPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQAL 206
V + P + WY+D + L S E + T++ R D G+ CEA N A
Sbjct: 2961 V-HAHPNPEVTWYKDSQAL----SLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 3015
Query: 207 PSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES-- 264
Q ++ + R +VR GD VL+C P P + W + +
Sbjct: 3016 RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYKDGQPLV 3074
Query: 265 LPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVP 322
L +R +A+ G+ L + +D G Y+C+ SN G A + L V P +T
Sbjct: 3075 LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV 3134
Query: 323 YAIVGGILAL 332
+ G L L
Sbjct: 3135 SQVAGSPLVL 3144
Score = 67.8 bits (164), Expect = 2e-11
Identities = 77/292 (26%), Positives = 123/292 (42%), Gaps = 26/292 (8%)
Query: 45 RLHQYDGSIVVIQNPARQTLFFN-----GTRALKDERFQLEEFSPRRVRIRLSDARLEDE 99
R+H Y +++ L F G L +ER E + +R S A +E
Sbjct: 435 RIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKA---EE 491
Query: 100 GGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVE-LSCLVPRSRPAATLRW 158
G Y C + + V+ P +V V GE LSC V P L W
Sbjct: 492 GTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY-NLTW 550
Query: 159 YRDRKELKGVSSSQENGKVWSVAS-TVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYV 217
RD + L G+V +A ++ DGG C A N +G ++ + ++
Sbjct: 551 VRDWRVLPA-----STGRVAQLADLSLEISGIIPTDGGRYQCVASNA---NGVTRASVWL 602
Query: 218 LDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPE----RAEAVG 273
L V+ +P IH S +G + ++C+ +G P P+ I W+R +++L E +A G
Sbjct: 603 L-VREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPH-ISWSRESQALQEDSRIHVDAQG 660
Query: 274 ETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAI 325
TL + G+ D G Y+C+A+N+ G + L DP +V V A+
Sbjct: 661 -TLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAV 711
Score = 67.8 bits (164), Expect = 2e-11
Identities = 70/238 (29%), Positives = 105/238 (44%), Gaps = 22/238 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHH-QIATLTVLVAP--ENPVVEVREQAVEGGEVELS 144
R+ + +A++ D+G Y C++ + TLTV V P ENP E Q V G + L+
Sbjct: 3087 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ-VAGSPLVLT 3145
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ 204
C V PA T+ W +DR V SS +G V S ++ + G C A+N
Sbjct: 3146 CDVS-GVPAPTVTWLKDRMP---VESSAVHGVV-SRGGRLQLSRLQPAQAGTYTCVAENT 3200
Query: 205 ALPSGHSKQTQYVLDVQYSPTARIH--ASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
+ + +V+ V +P R A + V EG + L C G P P+ + W +
Sbjct: 3201 QAEA----RKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAWLKDG 3255
Query: 263 ESLPE------RAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAV 314
L + R G +L L GL ++D G YTC A N G L+ + V P +
Sbjct: 3256 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTI 3313
Score = 61.2 bits (147), Expect = 2e-09
Identities = 72/288 (25%), Positives = 117/288 (40%), Gaps = 28/288 (9%)
Query: 25 QEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSP 84
Q V NVTV+ G A ++CR V+ + R L ++ + +
Sbjct: 519 QLVPAPNVTVSPGETAVLSCR---------VLGEAPYNLTWVRDWRVLPASTGRVAQLAD 569
Query: 85 RRVRIRLSDARLEDEGGYFCQLYTEDTHHQIAT-LTVLVAPENPVVEVREQAVEGGEVEL 143
+ + +S D G Y C + + + L V AP+ + + +G EV++
Sbjct: 570 --LSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKV 627
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVAS-TVRFRVDRKDDGGIIICEAQ 202
SC P + W R+ + L QE+ ++ A T+ + +D G C+A
Sbjct: 628 SCSAS-GYPTPHISWSRESQAL------QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQAT 680
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHASQAVV--REGDTLVLTCAVTGNPRPNQIRWNR 260
N+ G ++T + + Y+ + A AVV G+ VL C +G P P I +
Sbjct: 681 NEV---GTDQET---VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 734
Query: 261 GNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
G E + + L +P D GTYTC A N+ G A A L V
Sbjct: 735 GLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV 782
Score = 61.2 bits (147), Expect = 2e-09
Identities = 65/237 (27%), Positives = 97/237 (40%), Gaps = 26/237 (10%)
Query: 89 IRLSDARLEDEGGYFCQLYT---EDTHHQIATLTVLVAPE-NPVVEVREQAVEGGEVELS 144
+RL+ ++ D G Y C +H + L V V P+ P V + V G ++L+
Sbjct: 1084 LRLAQVQVGDSGHYECTASNPAGSASHRYV--LGVQVPPQVQPGPRVLKVLV-GEALDLN 1140
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ 204
C V P L W +D L+G +V F R D G CEA N
Sbjct: 1141 C-VAEGNPEPQLSWSKDGVVLQGRGPQ----------GSVHFAAIRTSDAGRYRCEASNS 1189
Query: 205 ALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES 264
A + + + + + V G+ L C G P+P Q+ W +G S
Sbjct: 1190 AGVDAWEVELRVLEPPHWGADETSGLLERVA--GENASLPCPARGTPKP-QVTWRKGPSS 1246
Query: 265 LPERAE---AVGE--TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVE 316
P + AV E +L L + AD+G Y C+A+N+ G LVVY P ++ E
Sbjct: 1247 EPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIRE 1303
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/251 (25%), Positives = 101/251 (40%), Gaps = 30/251 (11%)
Query: 91 LSDARLEDEGGYFCQLYT---EDTHHQIATLTVLVAPENPVVEVREQAVEG--------G 139
L R D G Y C + ED ++ T+ VLV P +Q +G G
Sbjct: 3277 LKGLRASDAGAYTCVAHNPAGEDA--RLHTVNVLVPP------TIKQGADGSGTLVSRPG 3328
Query: 140 EVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIIC 199
E+ R P + W +D L + +G T+R + D GI C
Sbjct: 3329 ELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGS----GHTLRISKVQLADAGIFTC 3384
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPTARIHASQ--AVVREGDTLVLTCAVTGNPRPNQIR 257
A A P+G + + + L VQ P Q VV G + L C G P P +
Sbjct: 3385 VA---ASPAGVADRN-FTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP-LVS 3439
Query: 258 WNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
W + E L ++ G +L L + + D+GTY+C A ++ G AR + L V +P + ++
Sbjct: 3440 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 3499
Query: 318 QTSVPYAIVGG 328
++ G
Sbjct: 3500 GQPTELSLTPG 3510
Score = 59.7 bits (143), Expect = 4e-09
Identities = 65/244 (26%), Positives = 101/244 (41%), Gaps = 24/244 (9%)
Query: 89 IRLSDARLEDEGGYFCQL--YTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCL 146
+++ L DEG Y C ++ ++A L VLV P V + +E V L CL
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 1908
Query: 147 VPRSRPAATLRWYRDRKELK---GVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQN 203
P + W++ + + GV+ S + G+V +R + D G C A N
Sbjct: 1909 AS-GVPPPDVSWFKGHQPVSSWMGVTVSVD-GRV------LRIEQAQLSDAGSYRCVASN 1960
Query: 204 QALPSGHSKQTQYVLDVQYSPTARIHAS-QAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
A S + +Y L V P + S V + LTC TG P P + GN
Sbjct: 1961 VA----GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 2016
Query: 263 ESLPERAEAV-----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
P + G LTL ++D+G Y+C A + G R VL V+ P +++
Sbjct: 2017 PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGE 2076
Query: 318 QTSV 321
+ +V
Sbjct: 2077 ELNV 2080
Score = 58.9 bits (141), Expect = 7e-09
Identities = 70/286 (24%), Positives = 113/286 (39%), Gaps = 33/286 (11%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVE---VREQAVEGGEVELS 144
++R++ A ED G Y C +++ T LV PV+E EG L
Sbjct: 4001 QLRIAHASPEDAGNYLC--IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 4058
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD--DGGIIICEAQ 202
C R P + W +D + + G +++ + V + D G C A+
Sbjct: 4059 CKA-RGSPEPNITWDKDGQPVSGAEGK------FTIQPSGELLVKNLEGQDAGTYTCTAE 4111
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
N G +++ + L + P +R GD L L CA G+P P +I W +
Sbjct: 4112 NAV---GRARRRVH-LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTP-RIGWTVND 4166
Query: 263 ESLPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
+ E G TL + D+GTY C A N+ G +A+ + V + + S
Sbjct: 4167 RPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFS 4226
Query: 321 VPYAIVGGILALLVFLIICVLVG-----MVWC--SVRQKGSYLTHE 359
VGG + L CV+ G + W + +GS+L H+
Sbjct: 4227 YLVEPVGGSIQL-----DCVVRGDPVPDIHWIKDGLPLRGSHLRHQ 4267
Score = 57.8 bits (138), Expect = 2e-08
Identities = 66/259 (25%), Positives = 106/259 (40%), Gaps = 24/259 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLY-TEDTHHQIATLTVLVAPE--NPVVEVREQAVEGGEVELS 144
R++LS + G Y C T+ + + VLVAP + V +EG EV L
Sbjct: 3179 RLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLD 3238
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENG---KVWSVASTVRFRVDRKDDGGIIICEA 201
C +P + W +D L Q+ G + + ++ + R D G C A
Sbjct: 3239 CEAD-GQPPPDVAWLKDGSPL-----GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA 3292
Query: 202 QNQALPSGHSKQTQYVLDVQYSPTARIHASQA---VVREGDTLVLTCAVTGNPRPNQIRW 258
N P+G + + ++V PT + A + V R G+ + + C V G+P P + W
Sbjct: 3293 HN---PAGEDARL-HTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP-PIHVSW 3347
Query: 259 NRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAV 314
+ LP + G TL + + AD G +TC A++ G A + L V P +
Sbjct: 3348 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVL 3407
Query: 315 VEAQTSVPYAIVGGILALL 333
+ +V G L L
Sbjct: 3408 EPVEFQNDVVVVRGSLVEL 3426
Score = 55.5 bits (132), Expect = 8e-08
Identities = 67/240 (27%), Positives = 93/240 (38%), Gaps = 25/240 (10%)
Query: 98 DEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQAV--EGGEVELSCLVPRSRPAA 154
D G Y C+ + T + L VL P ++ + G +VEL C P
Sbjct: 1380 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTP 1438
Query: 155 TLRWYRDRKELKGVSSS---QENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHS 211
+ W +DR+ + QE+G+V +R D G C A + P+G
Sbjct: 1439 QVEWTKDRQPVLPGGPHLQVQEDGQV------LRITGSHVGDEGRYQCVAFS---PAGQQ 1489
Query: 212 KQTQYVLDVQYSPT--ARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA 269
+ + L V PT + V E + L C G P PN I W + LP
Sbjct: 1490 AR-DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN-ITWFKDGALLPTST 1547
Query: 270 EAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAI 325
+ V G L L S+D G YTC+ASN G A L VY P +E PY +
Sbjct: 1548 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP-PTIEGAGGRPYVV 1606
Score = 55.5 bits (132), Expect = 8e-08
Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 22/226 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIAT-LTVLVAPENPVVEVRE---QAVEGGEVEL 143
+++L A+ D G Y C+ + AT L V V P R +AV G V L
Sbjct: 1557 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVAL 1616
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQEN-GKVWSVASTVRFRVDRKDDGGIIICEAQ 202
C V R P+ TL W+ + G+ ++ N ++ + S +R + G+ C A
Sbjct: 1617 EC-VARGHPSPTLSWHHE-----GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 1670
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHAS--QAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
+ P+G + QY ++VQ P + Q G L L C +G+P P I+W +
Sbjct: 1671 S---PAGEAV-LQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT-IQWLQ 1725
Query: 261 GNESLPERA----EAVGETLTLPGLVSADNGTYTCEASNKHGHARA 302
E A + G TL + + +G + C+A+N+ G A A
Sbjct: 1726 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGA 1771
Score = 52.0 bits (123), Expect = 9e-07
Identities = 56/223 (25%), Positives = 74/223 (33%), Gaps = 24/223 (10%)
Query: 97 EDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAT 155
ED G Y CQ E T + TL P V G E L C P
Sbjct: 670 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRV 729
Query: 156 LRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQ 215
+ WYR E+ +GK+ R ++ D G C A N+ + Q
Sbjct: 730 I-WYRGGLEMILAPEGSSSGKL-------RIPAAQERDAGTYTCRAVNELGDASAEIQ-- 779
Query: 216 YVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGE- 274
L V ++P V G + +L C TG P P + W RG+ G
Sbjct: 780 --LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPT-VTWRRGDGQPLGLRLGAGRG 836
Query: 275 ---------TLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
L + D Y CEA N G +A L+V
Sbjct: 837 SRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Score = 51.6 bits (122), Expect = 1e-06
Identities = 50/183 (27%), Positives = 70/183 (38%), Gaps = 22/183 (12%)
Query: 122 VAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVA 181
+A P V V +EG V L C+V RP W +D + L G S+
Sbjct: 887 IASSAPTVRV----LEGQPVSLPCIVLAGRPLPERHWLKDGRPL-------PPGSRHSIR 935
Query: 182 STVRFRVDR--KDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGD 239
+ +DR ++ G C A N A S+ L VQ P A+ + EG
Sbjct: 936 ADGSLHLDRALQEHAGRYSCVATNTA----GSQHRDVELVVQVPPRIHPTATHHITNEGV 991
Query: 240 TLVLTCAVTGNPRPNQIRWNRGNESLPERAE----AVGETLTLPGLVSADNGTYTCEASN 295
L C +G P P I W + +L R + TL + + D G Y C A+N
Sbjct: 992 PASLPCVASGVPAPT-ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050
Query: 296 KHG 298
G
Sbjct: 1051 TVG 1053
Score = 51.6 bits (122), Expect = 1e-06
Identities = 74/327 (22%), Positives = 120/327 (36%), Gaps = 48/327 (14%)
Query: 28 QTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV 87
++ +TV EG ++C P + + + L E L+ S
Sbjct: 2168 ESHTLTVREGHPTSLSCECRGV---------PFPKISWRKDGQPLPGEGAGLQHVSAVGR 2218
Query: 88 RIRLSDARLEDEGGYFCQLY------TEDTHHQIATLTVLVAPENPVVEVREQAVEGGEV 141
+ L A+L EG Y C+ ++D ++ + P P +V V+ G
Sbjct: 2219 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV--SVVQDGVA 2276
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDG--GIIIC 199
L C +P T+ W RD + + Q + S+ V+R G C
Sbjct: 2277 TLECNAT-GKPPPTVTWERDGQPVGAELGLQLQNQGQSL------HVERAQAAHTGRYSC 2329
Query: 200 EAQNQALPSGHSKQTQYV--------LDVQYSPTARIHASQAVVREGDTLVLTCAVTGNP 251
A+N A + + + LD + TA +H+ L L C G P
Sbjct: 2330 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP---------LTLLCEAMGIP 2380
Query: 252 RPNQIRWNRGNESLPERAE----AVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLV 307
P IRW RG E + + A G L + D+G Y+C ASN+ G AR + +
Sbjct: 2381 PP-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 2439
Query: 308 VYDPGAVVEAQTSVPYAIVGGILALLV 334
V P ++ ++ G A L+
Sbjct: 2440 VLVPPSIENEDLEEVIKVLDGQTAHLM 2466
Score = 51.2 bits (121), Expect = 2e-06
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 21/236 (8%)
Query: 95 RLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEG---GEVELSCLVPRSR 151
R+ D G Y C + + + + AP N V + V G G++ L C V +
Sbjct: 3550 RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSV-EAE 3608
Query: 152 PAATLRWYRDRKELKGVSSSQ--ENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSG 209
PA + W+RD L+ + +Q E G+ ++ + D G C A+N A
Sbjct: 3609 PAPKITWHRDGIVLQEDAHTQFPERGRF------LQLQALSTADSGDYSCTARNAA---- 3658
Query: 210 HSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA 269
S + +++ PT R V T +L C G P P + W + L R+
Sbjct: 3659 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAP-LVSWRKDRVPLDPRS 3717
Query: 270 ---EAVGE-TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSV 321
E + E +L + +++ D G Y C ASN G R L V +P A+ + +++
Sbjct: 3718 PRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 3773
Score = 50.4 bits (119), Expect = 3e-06
Identities = 65/248 (26%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 89 IRLSDARLEDEGGYFCQLYT------EDTHHQI-ATLTVLVAPENPVVEVREQAVEGGEV 141
+R++ + + DEG Y C ++ D ++ A T+ + E V V E + V
Sbjct: 1465 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL----V 1520
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDR--KDDGGIIIC 199
+L C R P + W++D L + KV + ++ R D G+ C
Sbjct: 1521 QLLCEA-RGVPTPNITWFKDGALLP------TSTKVVYTRGGRQLQLGRAQSSDAGVYTC 1573
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPT-----ARIHASQAVVREGDTLVLTCAVTGNPRPN 254
+A N K T+ LDV PT R + +AV G + L C G+P P
Sbjct: 1574 KASNAV--GAAEKATR--LDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPT 1627
Query: 255 QIRWNRGN----ESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD 310
+ W+ ES R E G L L A +G Y+C AS+ G A Y + V
Sbjct: 1628 -LSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 1686
Query: 311 PGAVVEAQ 318
P ++ A+
Sbjct: 1687 PPQLLVAE 1694
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/195 (28%), Positives = 76/195 (38%), Gaps = 19/195 (9%)
Query: 113 HQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELK-GVSSS 171
H+ LTV +P + +AV EV L C P T+ W ++ + GVS+
Sbjct: 3937 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS-GIPRPTITWQKEGLNVATGVSTQ 3995
Query: 172 QENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHAS 231
G +A +D G +C A+N A S + L VQ P
Sbjct: 3996 VLPGGQLRIAHA------SPEDAGNYLCIAKNSA----GSAMGKTRLVVQVPPVIENGLP 4045
Query: 232 QAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA-----EAVGETLTLPGLVSADN 286
EG L C G+P PN I W++ + + + GE L + L D
Sbjct: 4046 DLSTTEGSHAFLPCKARGSPEPN-ITWDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDA 4103
Query: 287 GTYTCEASNKHGHAR 301
GTYTC A N G AR
Sbjct: 4104 GTYTCTAENAVGRAR 4118
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/259 (24%), Positives = 106/259 (40%), Gaps = 42/259 (16%)
Query: 89 IRLSDARLEDEGGYFCQLYTE-----DTHHQIATLTVLVAPENPVVEVREQAVE---GGE 140
+++ +A+ ED G Y C + E +H + ++ ++P+ EV + V+
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNST 2656
Query: 141 VELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICE 200
+ L C + P T+RWY+D + + S Q G+ ++ + + D G +C
Sbjct: 2657 LTLEC-ESWAVPPPTIRWYKDGQPVTPSSRLQVLGE----GRLLQIQPTQVSDSGRYLCV 2711
Query: 201 AQNQALPSGHSKQTQYVLDV---------QYSPTARIHASQAVVREGDT----------L 241
A N A G Q VL +S I + + R G T
Sbjct: 2712 ATNVA---GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768
Query: 242 VLTCAVTGNPRPNQIRWNRGNESLPERAEAV----GETLTLPGLVSADN-GTYTCEASNK 296
L C P P+ + W R ++ L E G L +P LV A+N G Y+C+ASN+
Sbjct: 2769 YLYCDTNAIPPPD-LTWYREDQPLSAGDEVSVLQGGRVLQIP-LVRAENAGRYSCKASNE 2826
Query: 297 HGHARALYVLVVYDPGAVV 315
G Y L+V P ++
Sbjct: 2827 VGEDWLHYELLVLTPPVIL 2845
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/253 (24%), Positives = 99/253 (39%), Gaps = 38/253 (15%)
Query: 72 LKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTED----THHQIATLTVLVAPENP 127
+KD L + + ++L D G Y C +E H Q+ + E P
Sbjct: 3441 MKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM------EPP 3494
Query: 128 VVEVREQAVE-----GGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVAS 182
+E Q E G +EL C + P + W++D + L + ++
Sbjct: 3495 HIEDSGQPTELSLTPGAPMELLCDA-QGTPQPNITWHKDGQALTRLENNSR--------- 3544
Query: 183 TVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVV--REGDT 240
RV R D G+ C A++ P+G +++ + + VQ P V
Sbjct: 3545 --ATRVLRVRDAGLYTCLAES---PAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAPGQ 3598
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNK 296
LVL C+V P P +I W+R L E A G L L L +AD+G Y+C A N
Sbjct: 3599 LVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 3657
Query: 297 HGHARALYVLVVY 309
G + + ++
Sbjct: 3658 AGSTSVAFRVEIH 3670
Score = 45.4 bits (106), Expect = 9e-05
Identities = 47/190 (24%), Positives = 73/190 (38%), Gaps = 25/190 (13%)
Query: 152 PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHS 211
PA + W +DR L S E ++R + D G +C A N A G
Sbjct: 3700 PAPLVSWRKDRVPLDPRSPRFEI----LPEGSLRIQPVLAQDAGHYLCLASNSA---GSD 3752
Query: 212 KQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES------- 264
+Q + L V P S + +L C +G+P+P + W G +
Sbjct: 3753 RQGRD-LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG 3811
Query: 265 ----LPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
LP A LT PG D+ + C SN+ G A LY + V+ P + + QT
Sbjct: 3812 AYRLLPSNALL----LTAPG--PQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTD 3865
Query: 321 VPYAIVGGIL 330
++ ++
Sbjct: 3866 FTVTMMAPVV 3875
Score = 45.1 bits (105), Expect = 1e-04
Identities = 59/268 (22%), Positives = 96/268 (35%), Gaps = 29/268 (10%)
Query: 89 IRLSDARLEDEGGYFC---QLYTEDTHH-----QIATLTVLVAPENPVVEV--REQAVEG 138
+++ ++ D G Y C + ED Q+ + V + E+ RE+ G
Sbjct: 2695 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 2754
Query: 139 GEVELSCLVPRSR----------PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRV 188
G E +V + P L WYR+ + L S+ + V ++ +
Sbjct: 2755 GVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL----SAGDEVSVLQGGRVLQIPL 2810
Query: 189 DRKDDGGIIICEAQNQALPSG-HSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAV 247
R ++ G C+A N+ H + V T + + V T+ L C
Sbjct: 2811 VRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEEL-VEEVTVNASSTVSLQCPA 2869
Query: 248 TGNPRPNQIRWNRGNESLPERAEAV---GETLTLPGLVSADNGTYTCEASNKHGHARALY 304
GNP P G P V G+ L + AD +Y C A N+ G A L+
Sbjct: 2870 LGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLF 2929
Query: 305 VLVVYDPGAVVEAQTSVPYAIVGGILAL 332
L V P + AI+ ++L
Sbjct: 2930 TLRVQVPPRIAGLDLEQVTAILNSSVSL 2957
Score = 40.8 bits (94), Expect = 0.002
Identities = 59/244 (24%), Positives = 95/244 (38%), Gaps = 39/244 (15%)
Query: 98 DEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQA-------VEGGEVELSCLVPR 149
D G Y CQ E + + A L V V P +RE + G + L C
Sbjct: 1272 DSGDYECQATNEVGSTSRRAKLVVYVPPS-----IREDGRKANVSGMAGQSLTLECDA-N 1325
Query: 150 SRPAATLRWYRDRKELKGVSSSQENGKVWSVA-------------STVRFRVDRKDDGGI 196
P + W +D +L GV G W + ++ F ++ D G+
Sbjct: 1326 GFPVPEIVWLKDA-QLVGVPLGWA-GYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGL 1383
Query: 197 IICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVV-REGDTLVLTCAVTGNPRPNQ 255
C A+NQA G +++ ++L + A+Q V+ G + L C +G P P Q
Sbjct: 1384 YSCRAENQA---GTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTP-Q 1439
Query: 256 IRWNRGNES-LPE----RAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD 310
+ W + + LP + + G+ L + G D G Y C A + G + L V+
Sbjct: 1440 VEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA 1499
Query: 311 PGAV 314
P +
Sbjct: 1500 PPTI 1503
Score = 40.0 bits (92), Expect = 0.004
Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 21/201 (10%)
Query: 118 LTVLVAPE-----NPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQ 172
L+VLV PE +P+ + A + L C P A +RW+R + + +
Sbjct: 2344 LSVLVPPELIGDLDPLTNIT--AALHSPLTLLCEAMGIPPPA-IRWFRGEEPVSPGEDTY 2400
Query: 173 ENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQ 232
W + T ++ D G+ C A N+A G +++ + ++V P+ +
Sbjct: 2401 LLAGGWMLKMTQT----QEQDSGLYSCLASNEA---GEARRN-FSVEVLVPPSIENEDLE 2452
Query: 233 AVVR--EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSAD---NG 287
V++ +G T L C VTG+P+P + G A + L ++ A+ G
Sbjct: 2453 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAG 2512
Query: 288 TYTCEASNKHGHARALYVLVV 308
Y+C A+N G + L V
Sbjct: 2513 HYSCIAANAVGEKTKHFQLSV 2533
Score = 38.1 bits (87), Expect = 0.014
Identities = 38/145 (26%), Positives = 58/145 (40%), Gaps = 24/145 (16%)
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVR--EGDTLVLTCAVTGN 250
D G C+A N+ S + L V P+ R +A V G +L L C G
Sbjct: 1272 DSGDYECQATNEV----GSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 1327
Query: 251 PRPNQI-----------------RWNRG-NESLPERAEAVGETLTLPGLVSADNGTYTCE 292
P P + W+ G + R G++L P + D+G Y+C
Sbjct: 1328 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCR 1387
Query: 293 ASNKHGHARALYVLVVYDPGAVVEA 317
A N+ G A+ + L+V P +V+ A
Sbjct: 1388 AENQAGTAQRDFHLLVLTPPSVLGA 1412
Score = 35.8 bits (81), Expect = 0.067
Identities = 33/120 (27%), Positives = 46/120 (38%), Gaps = 18/120 (15%)
Query: 216 YVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL---------- 265
Y + V PT + V +VLTC TG P P + W++ L
Sbjct: 3849 YQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSWSKAGAQLGARGSGYRVS 3907
Query: 266 PERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAI 325
P A +G+ L + G YTC A N G A +V + VV+ SV A+
Sbjct: 3908 PSGALEIGQALPIHA------GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAV 3960
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 79.7 bits (195), Expect = 4e-15
Identities = 80/246 (32%), Positives = 106/246 (43%), Gaps = 29/246 (11%)
Query: 79 LEEFSPRRVRIRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQAVE 137
L+ F RV + L+ AR D G Y C + Q L V + P E+ V
Sbjct: 744 LQVFPGGRV-LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVA 802
Query: 138 GGEVELSCLVPRSRPAATLRWYRDRKELK---GVSSSQENGKVWSVASTVRFRVDRKD-- 192
V L C + P L W++D + L+ GV S A +VDR D
Sbjct: 803 NESVALECQ-SHAMPPPVLSWWKDGRPLEPRPGVHLS---------ADKALLQVDRADVW 852
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNP 251
D G CEA NQA GHS++ Y L+V +P + S + VREG L+C G P
Sbjct: 853 DAGHYTCEALNQA---GHSEK-HYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVP 908
Query: 252 RPNQIRWNRGNESLP------ERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYV 305
P +I W + + LP + AVG L L A GTYTCE SN G++
Sbjct: 909 FP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 967
Query: 306 LVVYDP 311
L V+ P
Sbjct: 968 LEVHVP 973
Score = 75.1 bits (183), Expect = 1e-13
Identities = 69/221 (31%), Positives = 104/221 (47%), Gaps = 24/221 (10%)
Query: 97 EDEGGYFCQLYTEDTHHQIATLTVLVAPENPVV--EVREQAVE--GGEVELSCLVPRSRP 152
ED G Y C + E+ + ++ + E PV+ E VE GG ++L C+V R P
Sbjct: 2908 EDSGTYVC--WAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDP 2964
Query: 153 AATLRWYRDRKELKG--VSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGH 210
+ W +D L+G + +NG + T+R R +R DD G C A+N+ G
Sbjct: 2965 VPDIHWIKDGLPLRGSHLRHQLQNGSL-----TIR-RTER-DDAGRYQCLAENEM---GV 3014
Query: 211 SKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL--PER 268
+K+ +L +Q +P ++ VR GD + L C TG P P I W + + L R
Sbjct: 3015 AKKV-VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT-IEWLQAGQPLRASRR 3072
Query: 269 AEAVGE-TLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
+ + +L L + + D GTY C A N G A A LVV
Sbjct: 3073 LRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3113
Score = 70.1 bits (170), Expect = 3e-12
Identities = 63/250 (25%), Positives = 103/250 (41%), Gaps = 12/250 (4%)
Query: 89 IRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVRE-QAVEGGEVELSCL 146
+++S A + D Y C + + ++ TL V V P +++ + A+ V L C
Sbjct: 1619 LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCD 1678
Query: 147 VPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQAL 206
V + P + WY+D + L S E + T++ R D G+ CEA N A
Sbjct: 1679 V-HAHPNPEVTWYKDSQAL----SLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 1733
Query: 207 PSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES-- 264
Q ++ + R +VR GD VL+C P P + W + +
Sbjct: 1734 RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYKDGQPLV 1792
Query: 265 LPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVP 322
L +R +A+ G+ L + +D G Y+C+ SN G A + L V P +T
Sbjct: 1793 LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV 1852
Query: 323 YAIVGGILAL 332
+ G L L
Sbjct: 1853 SQVAGSPLVL 1862
Score = 67.8 bits (164), Expect = 2e-11
Identities = 70/238 (29%), Positives = 105/238 (44%), Gaps = 22/238 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHH-QIATLTVLVAP--ENPVVEVREQAVEGGEVELS 144
R+ + +A++ D+G Y C++ + TLTV V P ENP E Q V G + L+
Sbjct: 1805 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ-VAGSPLVLT 1863
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ 204
C V PA T+ W +DR V SS +G V S ++ + G C A+N
Sbjct: 1864 CDVS-GVPAPTVTWLKDRMP---VESSAVHGVV-SRGGRLQLSRLQPAQAGTYTCVAENT 1918
Query: 205 ALPSGHSKQTQYVLDVQYSPTARIH--ASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
+ + +V+ V +P R A + V EG + L C G P P+ + W +
Sbjct: 1919 QAEA----RKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAWLKDG 1973
Query: 263 ESLPE------RAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAV 314
L + R G +L L GL ++D G YTC A N G L+ + V P +
Sbjct: 1974 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTI 2031
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/251 (25%), Positives = 101/251 (40%), Gaps = 30/251 (11%)
Query: 91 LSDARLEDEGGYFCQLYT---EDTHHQIATLTVLVAPENPVVEVREQAVEG--------G 139
L R D G Y C + ED ++ T+ VLV P +Q +G G
Sbjct: 1995 LKGLRASDAGAYTCVAHNPAGEDA--RLHTVNVLVPP------TIKQGADGSGTLVSRPG 2046
Query: 140 EVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIIC 199
E+ R P + W +D L + +G T+R + D GI C
Sbjct: 2047 ELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGS----GHTLRISKVQLADAGIFTC 2102
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPTARIHASQ--AVVREGDTLVLTCAVTGNPRPNQIR 257
A A P+G + + + L VQ P Q VV G + L C G P P +
Sbjct: 2103 VA---ASPAGVADRN-FTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP-LVS 2157
Query: 258 WNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
W + E L ++ G +L L + + D+GTY+C A ++ G AR + L V +P + ++
Sbjct: 2158 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2217
Query: 318 QTSVPYAIVGG 328
++ G
Sbjct: 2218 GQPTELSLTPG 2228
Score = 59.7 bits (143), Expect = 4e-09
Identities = 65/244 (26%), Positives = 101/244 (41%), Gaps = 24/244 (9%)
Query: 89 IRLSDARLEDEGGYFCQL--YTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCL 146
+++ L DEG Y C ++ ++A L VLV P V + +E V L CL
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 626
Query: 147 VPRSRPAATLRWYRDRKELK---GVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQN 203
P + W++ + + GV+ S + G+V +R + D G C A N
Sbjct: 627 AS-GVPPPDVSWFKGHQPVSSWMGVTVSVD-GRV------LRIEQAQLSDAGSYRCVASN 678
Query: 204 QALPSGHSKQTQYVLDVQYSPTARIHAS-QAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
A S + +Y L V P + S V + LTC TG P P + GN
Sbjct: 679 VA----GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 734
Query: 263 ESLPERAEAV-----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
P + G LTL ++D+G Y+C A + G R VL V+ P +++
Sbjct: 735 PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGE 794
Query: 318 QTSV 321
+ +V
Sbjct: 795 ELNV 798
Score = 58.9 bits (141), Expect = 7e-09
Identities = 70/286 (24%), Positives = 113/286 (39%), Gaps = 33/286 (11%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVE---VREQAVEGGEVELS 144
++R++ A ED G Y C +++ T LV PV+E EG L
Sbjct: 2719 QLRIAHASPEDAGNYLC--IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2776
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD--DGGIIICEAQ 202
C R P + W +D + + G +++ + V + D G C A+
Sbjct: 2777 CKA-RGSPEPNITWDKDGQPVSGAEGK------FTIQPSGELLVKNLEGQDAGTYTCTAE 2829
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
N G +++ + L + P +R GD L L CA G+P P +I W +
Sbjct: 2830 NAV---GRARRRVH-LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTP-RIGWTVND 2884
Query: 263 ESLPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
+ E G TL + D+GTY C A N+ G +A+ + V + + S
Sbjct: 2885 RPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFS 2944
Query: 321 VPYAIVGGILALLVFLIICVLVG-----MVWC--SVRQKGSYLTHE 359
VGG + L CV+ G + W + +GS+L H+
Sbjct: 2945 YLVEPVGGSIQL-----DCVVRGDPVPDIHWIKDGLPLRGSHLRHQ 2985
Score = 57.8 bits (138), Expect = 2e-08
Identities = 66/259 (25%), Positives = 106/259 (40%), Gaps = 24/259 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLY-TEDTHHQIATLTVLVAPE--NPVVEVREQAVEGGEVELS 144
R++LS + G Y C T+ + + VLVAP + V +EG EV L
Sbjct: 1897 RLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLD 1956
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENG---KVWSVASTVRFRVDRKDDGGIIICEA 201
C +P + W +D L Q+ G + + ++ + R D G C A
Sbjct: 1957 CEAD-GQPPPDVAWLKDGSPL-----GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA 2010
Query: 202 QNQALPSGHSKQTQYVLDVQYSPTARIHASQA---VVREGDTLVLTCAVTGNPRPNQIRW 258
N P+G + + ++V PT + A + V R G+ + + C V G+P P + W
Sbjct: 2011 HN---PAGEDARL-HTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP-PIHVSW 2065
Query: 259 NRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAV 314
+ LP + G TL + + AD G +TC A++ G A + L V P +
Sbjct: 2066 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVL 2125
Query: 315 VEAQTSVPYAIVGGILALL 333
+ +V G L L
Sbjct: 2126 EPVEFQNDVVVVRGSLVEL 2144
Score = 55.5 bits (132), Expect = 8e-08
Identities = 67/240 (27%), Positives = 93/240 (38%), Gaps = 25/240 (10%)
Query: 98 DEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQAV--EGGEVELSCLVPRSRPAA 154
D G Y C+ + T + L VL P ++ + G +VEL C P
Sbjct: 98 DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTP 156
Query: 155 TLRWYRDRKELKGVSSS---QENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHS 211
+ W +DR+ + QE+G+V +R D G C A + P+G
Sbjct: 157 QVEWTKDRQPVLPGGPHLQVQEDGQV------LRITGSHVGDEGRYQCVAFS---PAGQQ 207
Query: 212 KQTQYVLDVQYSPT--ARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA 269
+ + L V PT + V E + L C G P PN I W + LP
Sbjct: 208 AR-DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN-ITWFKDGALLPTST 265
Query: 270 EAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAI 325
+ V G L L S+D G YTC+ASN G A L VY P +E PY +
Sbjct: 266 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP-PTIEGAGGRPYVV 324
Score = 55.5 bits (132), Expect = 8e-08
Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 22/226 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIAT-LTVLVAPENPVVEVRE---QAVEGGEVEL 143
+++L A+ D G Y C+ + AT L V V P R +AV G V L
Sbjct: 275 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVAL 334
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQEN-GKVWSVASTVRFRVDRKDDGGIIICEAQ 202
C V R P+ TL W+ + G+ ++ N ++ + S +R + G+ C A
Sbjct: 335 EC-VARGHPSPTLSWHHE-----GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 388
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHAS--QAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
+ P+G + QY ++VQ P + Q G L L C +G+P P I+W +
Sbjct: 389 S---PAGEAV-LQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT-IQWLQ 443
Query: 261 GNESLPERA----EAVGETLTLPGLVSADNGTYTCEASNKHGHARA 302
E A + G TL + + +G + C+A+N+ G A A
Sbjct: 444 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGA 489
Score = 51.6 bits (122), Expect = 1e-06
Identities = 74/327 (22%), Positives = 120/327 (36%), Gaps = 48/327 (14%)
Query: 28 QTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV 87
++ +TV EG ++C P + + + L E L+ S
Sbjct: 886 ESHTLTVREGHPTRLSCECRGV---------PFPKISWRKDGQPLPGEGAGLQHVSAVGR 936
Query: 88 RIRLSDARLEDEGGYFCQLY------TEDTHHQIATLTVLVAPENPVVEVREQAVEGGEV 141
+ L A+L EG Y C+ ++D ++ + P P +V V+ G
Sbjct: 937 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV--SVVQDGVA 994
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDG--GIIIC 199
L C +P T+ W RD + + Q + S+ V+R G C
Sbjct: 995 TLECNAT-GKPPPTVTWERDGQPVGAELGLQLQNQGQSL------HVERAQAAHTGRYSC 1047
Query: 200 EAQNQALPSGHSKQTQYV--------LDVQYSPTARIHASQAVVREGDTLVLTCAVTGNP 251
A+N A + + + LD + TA +H+ L L C G P
Sbjct: 1048 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP---------LTLLCEAMGIP 1098
Query: 252 RPNQIRWNRGNESLPERAE----AVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLV 307
P IRW RG E + + A G L + D+G Y+C ASN+ G AR + +
Sbjct: 1099 PP-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1157
Query: 308 VYDPGAVVEAQTSVPYAIVGGILALLV 334
V P ++ ++ G A L+
Sbjct: 1158 VLVPPSIENEDLEEVIKVLDGQTAHLM 1184
Score = 51.2 bits (121), Expect = 2e-06
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 21/236 (8%)
Query: 95 RLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEG---GEVELSCLVPRSR 151
R+ D G Y C + + + + AP N V + V G G++ L C V +
Sbjct: 2268 RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSV-EAE 2326
Query: 152 PAATLRWYRDRKELKGVSSSQ--ENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSG 209
PA + W+RD L+ + +Q E G+ ++ + D G C A+N A
Sbjct: 2327 PAPKITWHRDGIVLQEDAHTQFPERGRF------LQLQALSTADSGDYSCTARNAA---- 2376
Query: 210 HSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA 269
S + +++ PT R V T +L C G P P + W + L R+
Sbjct: 2377 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAP-LVSWRKDRVPLDPRS 2435
Query: 270 ---EAVGE-TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSV 321
E + E +L + +++ D G Y C ASN G R L V +P A+ + +++
Sbjct: 2436 PRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 2491
Score = 50.4 bits (119), Expect = 3e-06
Identities = 65/248 (26%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 89 IRLSDARLEDEGGYFCQLYT------EDTHHQI-ATLTVLVAPENPVVEVREQAVEGGEV 141
+R++ + + DEG Y C ++ D ++ A T+ + E V V E + V
Sbjct: 183 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL----V 238
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDR--KDDGGIIIC 199
+L C R P + W++D L + KV + ++ R D G+ C
Sbjct: 239 QLLCEA-RGVPTPNITWFKDGALLP------TSTKVVYTRGGRQLQLGRAQSSDAGVYTC 291
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPT-----ARIHASQAVVREGDTLVLTCAVTGNPRPN 254
+A N K T+ LDV PT R + +AV G + L C G+P P
Sbjct: 292 KASNAV--GAAEKATR--LDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPT 345
Query: 255 QIRWNRGN----ESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD 310
+ W+ ES R E G L L A +G Y+C AS+ G A Y + V
Sbjct: 346 -LSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 404
Query: 311 PGAVVEAQ 318
P ++ A+
Sbjct: 405 PPQLLVAE 412
Score = 49.7 bits (117), Expect = 5e-06
Identities = 64/259 (24%), Positives = 106/259 (40%), Gaps = 42/259 (16%)
Query: 89 IRLSDARLEDEGGYFCQLYTE-----DTHHQIATLTVLVAPENPVVEVREQAVE---GGE 140
+++ +A+ ED G Y C + E +H + ++ ++P+ EV + V+
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNST 1374
Query: 141 VELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICE 200
+ L C + P T+RWY+D + + S Q G+ ++ + + D G +C
Sbjct: 1375 LTLEC-ESWAVPPPTIRWYKDGQPVTPSSRLQVLGE----GRLLQIQPTQVSDSGRYLCV 1429
Query: 201 AQNQALPSGHSKQTQYVLDV---------QYSPTARIHASQAVVREGDT----------L 241
A N A G Q VL +S I + + R G T
Sbjct: 1430 ATNVA---GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486
Query: 242 VLTCAVTGNPRPNQIRWNRGNESLPERAEAV----GETLTLPGLVSADN-GTYTCEASNK 296
L C P P+ + W R ++ L E G L +P LV A+N G Y+C+ASN+
Sbjct: 1487 YLYCDTNAIPPPD-LTWYREDQPLSAGDEVSVLQGGRVLQIP-LVRAENAGRYSCKASNE 1544
Query: 297 HGHARALYVLVVYDPGAVV 315
G Y L+V P ++
Sbjct: 1545 VGEDWLHYELLVLTPPVIL 1563
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/195 (28%), Positives = 76/195 (38%), Gaps = 19/195 (9%)
Query: 113 HQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELK-GVSSS 171
H+ LTV +P + +AV EV L C P T+ W ++ + GVS+
Sbjct: 2655 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS-GIPRPTITWQKEGLNVATGVSTQ 2713
Query: 172 QENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHAS 231
G +A +D G +C A+N A S + L VQ P
Sbjct: 2714 VLPGGQLRIAHA------SPEDAGNYLCIAKNSA----GSAMGKTRLVVQVPPVIENGLP 2763
Query: 232 QAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA-----EAVGETLTLPGLVSADN 286
EG L C G+P PN I W++ + + + GE L + L D
Sbjct: 2764 DLSTTEGSHAFLPCKARGSPEPN-ITWDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDA 2821
Query: 287 GTYTCEASNKHGHAR 301
GTYTC A N G AR
Sbjct: 2822 GTYTCTAENAVGRAR 2836
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/253 (24%), Positives = 99/253 (39%), Gaps = 38/253 (15%)
Query: 72 LKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTED----THHQIATLTVLVAPENP 127
+KD L + + ++L D G Y C +E H Q+ + E P
Sbjct: 2159 MKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM------EPP 2212
Query: 128 VVEVREQAVE-----GGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVAS 182
+E Q E G +EL C + P + W++D + L + ++
Sbjct: 2213 HIEDSGQPTELSLTPGAPMELLCDA-QGTPQPNITWHKDGQALTRLENNSR--------- 2262
Query: 183 TVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVV--REGDT 240
RV R D G+ C A++ P+G +++ + + VQ P V
Sbjct: 2263 --ATRVLRVRDAGLYTCLAES---PAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAPGQ 2316
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNK 296
LVL C+V P P +I W+R L E A G L L L +AD+G Y+C A N
Sbjct: 2317 LVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2375
Query: 297 HGHARALYVLVVY 309
G + + ++
Sbjct: 2376 AGSTSVAFRVEIH 2388
Score = 45.4 bits (106), Expect = 9e-05
Identities = 47/190 (24%), Positives = 73/190 (38%), Gaps = 25/190 (13%)
Query: 152 PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHS 211
PA + W +DR L S E ++R + D G +C A N A G
Sbjct: 2418 PAPLVSWRKDRVPLDPRSPRFEI----LPEGSLRIQPVLAQDAGHYLCLASNSA---GSD 2470
Query: 212 KQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES------- 264
+Q + L V P S + +L C +G+P+P + W G +
Sbjct: 2471 RQGRD-LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG 2529
Query: 265 ----LPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
LP A LT PG D+ + C SN+ G A LY + V+ P + + QT
Sbjct: 2530 AYRLLPSNALL----LTAPG--PQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTD 2583
Query: 321 VPYAIVGGIL 330
++ ++
Sbjct: 2584 FTVTMMAPVV 2593
Score = 45.1 bits (105), Expect = 1e-04
Identities = 59/268 (22%), Positives = 96/268 (35%), Gaps = 29/268 (10%)
Query: 89 IRLSDARLEDEGGYFC---QLYTEDTHH-----QIATLTVLVAPENPVVEV--REQAVEG 138
+++ ++ D G Y C + ED Q+ + V + E+ RE+ G
Sbjct: 1413 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 1472
Query: 139 GEVELSCLVPRSR----------PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRV 188
G E +V + P L WYR+ + L S+ + V ++ +
Sbjct: 1473 GVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL----SAGDEVSVLQGGRVLQIPL 1528
Query: 189 DRKDDGGIIICEAQNQALPSG-HSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAV 247
R ++ G C+A N+ H + V T + + V T+ L C
Sbjct: 1529 VRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEEL-VEEVTVNASSTVSLQCPA 1587
Query: 248 TGNPRPNQIRWNRGNESLPERAEAV---GETLTLPGLVSADNGTYTCEASNKHGHARALY 304
GNP P G P V G+ L + AD +Y C A N+ G A L+
Sbjct: 1588 LGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLF 1647
Query: 305 VLVVYDPGAVVEAQTSVPYAIVGGILAL 332
L V P + AI+ ++L
Sbjct: 1648 TLRVQVPPRIAGLDLEQVTAILNSSVSL 1675
Score = 40.0 bits (92), Expect = 0.004
Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 21/201 (10%)
Query: 118 LTVLVAPE-----NPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQ 172
L+VLV PE +P+ + A + L C P A +RW+R + + +
Sbjct: 1062 LSVLVPPELIGDLDPLTNIT--AALHSPLTLLCEAMGIPPPA-IRWFRGEEPVSPGEDTY 1118
Query: 173 ENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQ 232
W + T ++ D G+ C A N+A G +++ + ++V P+ +
Sbjct: 1119 LLAGGWMLKMTQT----QEQDSGLYSCLASNEA---GEARRN-FSVEVLVPPSIENEDLE 1170
Query: 233 AVVR--EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSAD---NG 287
V++ +G T L C VTG+P+P + G A + L ++ A+ G
Sbjct: 1171 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAG 1230
Query: 288 TYTCEASNKHGHARALYVLVV 308
Y+C A+N G + L V
Sbjct: 1231 HYSCIAANAVGEKTKHFQLSV 1251
Score = 38.9 bits (89), Expect = 0.008
Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 10/131 (7%)
Query: 190 RKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVV-REGDTLVLTCAVT 248
++ D G+ C A+NQA G +++ ++L + A+Q V+ G + L C +
Sbjct: 95 QEGDSGLYSCRAENQA---GTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS 151
Query: 249 GNPRPNQIRWNRGNES-LPE----RAEAVGETLTLPGLVSADNGTYTCEASNKHGHARAL 303
G P P Q+ W + + LP + + G+ L + G D G Y C A + G
Sbjct: 152 GVPTP-QVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 210
Query: 304 YVLVVYDPGAV 314
+ L V+ P +
Sbjct: 211 FQLRVHAPPTI 221
Score = 35.8 bits (81), Expect = 0.067
Identities = 33/120 (27%), Positives = 46/120 (38%), Gaps = 18/120 (15%)
Query: 216 YVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL---------- 265
Y + V PT + V +VLTC TG P P + W++ L
Sbjct: 2567 YQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSWSKAGAQLGARGSGYRVS 2625
Query: 266 PERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAI 325
P A +G+ L + G YTC A N G A +V + VV+ SV A+
Sbjct: 2626 PSGALEIGQALPIHA------GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAV 2678
Score = 34.7 bits (78), Expect = 0.15
Identities = 16/45 (35%), Positives = 27/45 (60%)
Query: 273 GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
G++L P + D+G Y+C A N+ G A+ + L+V P +V+ A
Sbjct: 86 GQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 130
>gi|42560237 poliovirus receptor-related 1 isoform 1 [Homo sapiens]
Length = 517
Score = 77.4 bits (189), Expect = 2e-14
Identities = 91/331 (27%), Positives = 138/331 (41%), Gaps = 44/331 (13%)
Query: 54 VVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV--RIRLSDARLEDEGGYFCQLYTEDT 111
V I NP+ G L R ++E P IRLS LEDEG Y C+ T T
Sbjct: 78 VAIYNPSM------GVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPT 131
Query: 112 HHQIA--TLTVLVAPENPVVEVRE--QAVEGGEVEL---SCLVPRSRPAATLRWYRDRKE 164
++ + LTV+ P N + + +A +G + ++ +C +P + + W
Sbjct: 132 GNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSW---ETR 188
Query: 165 LKGVSSSQE----NGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDV 220
LKG + QE NG V +V S R R+ + C + L+V
Sbjct: 189 LKGEAEYQEIRNPNGTV-TVISRYRLVPSREAHQQSLACIVNYHM----DRFKESLTLNV 243
Query: 221 QYSPTARIHASQA--VVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTL 278
QY P I ++ D + LTC NP + W N SLP+ EA TL
Sbjct: 244 QYEPEVTIEGFDGNWYLQRMD-VKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFF 302
Query: 279 PGLVSAD-NGTYTCEASN----KHGHARALYVLVVYDPGAVVEAQTS--VPYAIVGGILA 331
G ++ GTY CEA+N + G Y P + + VP AI+GG+
Sbjct: 303 KGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAG 362
Query: 332 LLVFLIICVLVGMVWCSVRQ-----KGSYLT 357
+ L++ ++VG + ++R+ KG Y T
Sbjct: 363 SI--LLVLIVVGGIVVALRRRRHTFKGDYST 391
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 77.0 bits (188), Expect = 3e-14
Identities = 79/246 (32%), Positives = 105/246 (42%), Gaps = 29/246 (11%)
Query: 79 LEEFSPRRVRIRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVREQAVE 137
L+ F RV + L+ AR D G Y C + Q L V + P E+ V
Sbjct: 835 LQVFPGGRV-LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVA 893
Query: 138 GGEVELSCLVPRSRPAATLRWYRDRKELK---GVSSSQENGKVWSVASTVRFRVDRKD-- 192
V L C + P L W++D + L+ GV S A +VDR D
Sbjct: 894 NESVALECQ-SHAMPPPVLSWWKDGRPLEPRPGVHLS---------ADKALLQVDRADVW 943
Query: 193 DGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNP 251
D G CEA NQA G S++ Y L+V +P + S + VREG L+C G P
Sbjct: 944 DAGHYTCEALNQA---GRSEK-HYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVP 999
Query: 252 RPNQIRWNRGNESLP------ERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYV 305
P +I W + + LP + AVG L L A GTYTCE SN G++
Sbjct: 1000 FP-KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 1058
Query: 306 LVVYDP 311
L V+ P
Sbjct: 1059 LEVHVP 1064
Score = 73.6 bits (179), Expect = 3e-13
Identities = 68/221 (30%), Positives = 101/221 (45%), Gaps = 24/221 (10%)
Query: 97 EDEGGYFCQLYTEDTHHQIATLTVLVAPENPVV--EVREQAVE--GGEVELSCLVPRSRP 152
ED G Y C + E+ + ++ + E PV+ E VE GG ++L C+V R P
Sbjct: 2999 EDSGTYVC--WAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVV-RGDP 3055
Query: 153 AATLRWYRDRKELKG--VSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGH 210
+ W +D L+G + +NG S R +R DD G C A+N+ G
Sbjct: 3056 VPDIHWIKDGLPLRGSHLRHQLQNG------SLTIHRTER-DDAGRYQCLAENEM---GV 3105
Query: 211 SKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL--PER 268
+K+ +L +Q +P ++ VR GD + L C TG P P I W + + L R
Sbjct: 3106 AKKV-VILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT-IEWLQAGQPLRASRR 3163
Query: 269 AEAVGE-TLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
+ + +L L + + D GTY C A N G A A LVV
Sbjct: 3164 LRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3204
Score = 70.1 bits (170), Expect = 3e-12
Identities = 63/250 (25%), Positives = 103/250 (41%), Gaps = 12/250 (4%)
Query: 89 IRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVRE-QAVEGGEVELSCL 146
+++S A + D Y C + + ++ TL V V P +++ + A+ V L C
Sbjct: 1710 LQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCD 1769
Query: 147 VPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQAL 206
V + P + WY+D + L S E + T++ R D G+ CEA N A
Sbjct: 1770 V-HAHPNPEVTWYKDSQAL----SLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAG 1824
Query: 207 PSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES-- 264
Q ++ + R +VR GD VL+C P P + W + +
Sbjct: 1825 RDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYKDGQPLV 1883
Query: 265 LPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVP 322
L +R +A+ G+ L + +D G Y+C+ SN G A + L V P +T
Sbjct: 1884 LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV 1943
Query: 323 YAIVGGILAL 332
+ G L L
Sbjct: 1944 SQVAGSPLVL 1953
Score = 67.8 bits (164), Expect = 2e-11
Identities = 70/238 (29%), Positives = 105/238 (44%), Gaps = 22/238 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHH-QIATLTVLVAP--ENPVVEVREQAVEGGEVELS 144
R+ + +A++ D+G Y C++ + TLTV V P ENP E Q V G + L+
Sbjct: 1896 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQ-VAGSPLVLT 1954
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQ 204
C V PA T+ W +DR V SS +G V S ++ + G C A+N
Sbjct: 1955 CDVS-GVPAPTVTWLKDRMP---VESSAVHGVV-SRGGRLQLSRLQPAQAGTYTCVAENT 2009
Query: 205 ALPSGHSKQTQYVLDVQYSPTARIH--ASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
+ + +V+ V +P R A + V EG + L C G P P+ + W +
Sbjct: 2010 QAEA----RKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAWLKDG 2064
Query: 263 ESLPE------RAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAV 314
L + R G +L L GL ++D G YTC A N G L+ + V P +
Sbjct: 2065 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTI 2122
Score = 60.8 bits (146), Expect = 2e-09
Identities = 65/251 (25%), Positives = 101/251 (40%), Gaps = 30/251 (11%)
Query: 91 LSDARLEDEGGYFCQLYT---EDTHHQIATLTVLVAPENPVVEVREQAVEG--------G 139
L R D G Y C + ED ++ T+ VLV P +Q +G G
Sbjct: 2086 LKGLRASDAGAYTCVAHNPAGEDA--RLHTVNVLVPP------TIKQGADGSGTLVSRPG 2137
Query: 140 EVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIIC 199
E+ R P + W +D L + +G T+R + D GI C
Sbjct: 2138 ELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGS----GHTLRISKVQLADAGIFTC 2193
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPTARIHASQ--AVVREGDTLVLTCAVTGNPRPNQIR 257
A A P+G + + + L VQ P Q VV G + L C G P P +
Sbjct: 2194 VA---ASPAGVADRN-FTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP-LVS 2248
Query: 258 WNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
W + E L ++ G +L L + + D+GTY+C A ++ G AR + L V +P + ++
Sbjct: 2249 WMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDS 2308
Query: 318 QTSVPYAIVGG 328
++ G
Sbjct: 2309 GQPTELSLTPG 2319
Score = 59.7 bits (143), Expect = 4e-09
Identities = 65/244 (26%), Positives = 101/244 (41%), Gaps = 24/244 (9%)
Query: 89 IRLSDARLEDEGGYFCQL--YTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCL 146
+++ L DEG Y C ++ ++A L VLV P V + +E V L CL
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVTLECL 717
Query: 147 VPRSRPAATLRWYRDRKELK---GVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQN 203
P + W++ + + GV+ S + G+V +R + D G C A N
Sbjct: 718 AS-GVPPPDVSWFKGHQPVSSWMGVTVSVD-GRV------LRIEQAQLSDAGSYRCVASN 769
Query: 204 QALPSGHSKQTQYVLDVQYSPTARIHAS-QAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
A S + +Y L V P + S V + LTC TG P P + GN
Sbjct: 770 VA----GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGN 825
Query: 263 ESLPERAEAV-----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
P + G LTL ++D+G Y+C A + G R VL V+ P +++
Sbjct: 826 PVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGE 885
Query: 318 QTSV 321
+ +V
Sbjct: 886 ELNV 889
Score = 58.9 bits (141), Expect = 7e-09
Identities = 70/286 (24%), Positives = 113/286 (39%), Gaps = 33/286 (11%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVE---VREQAVEGGEVELS 144
++R++ A ED G Y C +++ T LV PV+E EG L
Sbjct: 2810 QLRIAHASPEDAGNYLC--IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLP 2867
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKD--DGGIIICEAQ 202
C R P + W +D + + G +++ + V + D G C A+
Sbjct: 2868 CKA-RGSPEPNITWDKDGQPVSGAEGK------FTIQPSGELLVKNLEGQDAGTYTCTAE 2920
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
N G +++ + L + P +R GD L L CA G+P P +I W +
Sbjct: 2921 NAV---GRARRRVH-LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTP-RIGWTVND 2975
Query: 263 ESLPERAEAV--GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
+ E G TL + D+GTY C A N+ G +A+ + V + + S
Sbjct: 2976 RPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFS 3035
Query: 321 VPYAIVGGILALLVFLIICVLVG-----MVWC--SVRQKGSYLTHE 359
VGG + L CV+ G + W + +GS+L H+
Sbjct: 3036 YLVEPVGGSIQL-----DCVVRGDPVPDIHWIKDGLPLRGSHLRHQ 3076
Score = 57.8 bits (138), Expect = 2e-08
Identities = 66/259 (25%), Positives = 106/259 (40%), Gaps = 24/259 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLY-TEDTHHQIATLTVLVAPE--NPVVEVREQAVEGGEVELS 144
R++LS + G Y C T+ + + VLVAP + V +EG EV L
Sbjct: 1988 RLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLD 2047
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSSQENG---KVWSVASTVRFRVDRKDDGGIIICEA 201
C +P + W +D L Q+ G + + ++ + R D G C A
Sbjct: 2048 CEAD-GQPPPDVAWLKDGSPL-----GQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVA 2101
Query: 202 QNQALPSGHSKQTQYVLDVQYSPTARIHASQA---VVREGDTLVLTCAVTGNPRPNQIRW 258
N P+G + + ++V PT + A + V R G+ + + C V G+P P + W
Sbjct: 2102 HN---PAGEDARL-HTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSP-PIHVSW 2156
Query: 259 NRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAV 314
+ LP + G TL + + AD G +TC A++ G A + L V P +
Sbjct: 2157 LKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVL 2216
Query: 315 VEAQTSVPYAIVGGILALL 333
+ +V G L L
Sbjct: 2217 EPVEFQNDVVVVRGSLVEL 2235
Score = 55.5 bits (132), Expect = 8e-08
Identities = 61/226 (26%), Positives = 98/226 (43%), Gaps = 22/226 (9%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIAT-LTVLVAPENPVVEVRE---QAVEGGEVEL 143
+++L A+ D G Y C+ + AT L V V P R +AV G V L
Sbjct: 366 QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVAL 425
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQEN-GKVWSVASTVRFRVDRKDDGGIIICEAQ 202
C V R P+ TL W+ + G+ ++ N ++ + S +R + G+ C A
Sbjct: 426 EC-VARGHPSPTLSWHHE-----GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 479
Query: 203 NQALPSGHSKQTQYVLDVQYSPTARIHAS--QAVVREGDTLVLTCAVTGNPRPNQIRWNR 260
+ P+G + QY ++VQ P + Q G L L C +G+P P I+W +
Sbjct: 480 S---PAGEAV-LQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT-IQWLQ 534
Query: 261 GNESLPERA----EAVGETLTLPGLVSADNGTYTCEASNKHGHARA 302
E A + G TL + + +G + C+A+N+ G A A
Sbjct: 535 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGA 580
Score = 54.7 bits (130), Expect = 1e-07
Identities = 58/197 (29%), Positives = 78/197 (39%), Gaps = 22/197 (11%)
Query: 138 GGEVELSCLVPRSRPAATLRWYRDRKELKGVSSS---QENGKVWSVASTVRFRVDRKDDG 194
G +VEL C P + W +DR+ + QE+G+V +R D
Sbjct: 232 GADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV------LRITGSHVGDE 284
Query: 195 GIIICEAQNQALPSGHSKQTQYVLDVQYSPT--ARIHASQAVVREGDTLVLTCAVTGNPR 252
G C A + P+G + + L V PT + V E + L C G P
Sbjct: 285 GRYQCVAFS---PAGQQAR-DFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPT 340
Query: 253 PNQIRWNRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVV 308
PN I W + LP + V G L L S+D G YTC+ASN G A L V
Sbjct: 341 PN-ITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 399
Query: 309 YDPGAVVEAQTSVPYAI 325
Y P +E PY +
Sbjct: 400 YVP-PTIEGAGGRPYVV 415
Score = 51.6 bits (122), Expect = 1e-06
Identities = 74/327 (22%), Positives = 120/327 (36%), Gaps = 48/327 (14%)
Query: 28 QTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRV 87
++ +TV EG ++C P + + + L E L+ S
Sbjct: 977 ESHTLTVREGHPTSLSCECRGV---------PFPKISWRKDGQPLPGEGAGLQHVSAVGR 1027
Query: 88 RIRLSDARLEDEGGYFCQLY------TEDTHHQIATLTVLVAPENPVVEVREQAVEGGEV 141
+ L A+L EG Y C+ ++D ++ + P P +V V+ G
Sbjct: 1028 LLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV--SVVQDGVA 1085
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDG--GIIIC 199
L C +P T+ W RD + + Q + S+ V+R G C
Sbjct: 1086 TLECNAT-GKPPPTVTWERDGQPVGAELGLQLQNQGQSL------HVERAQAAHTGRYSC 1138
Query: 200 EAQNQALPSGHSKQTQYV--------LDVQYSPTARIHASQAVVREGDTLVLTCAVTGNP 251
A+N A + + + LD + TA +H+ L L C G P
Sbjct: 1139 VAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSP---------LTLLCEAMGIP 1189
Query: 252 RPNQIRWNRGNESLPERAE----AVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLV 307
P IRW RG E + + A G L + D+G Y+C ASN+ G AR + +
Sbjct: 1190 PP-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE 1248
Query: 308 VYDPGAVVEAQTSVPYAIVGGILALLV 334
V P ++ ++ G A L+
Sbjct: 1249 VLVPPSIENEDLEEVIKVLDGQTAHLM 1275
Score = 51.2 bits (121), Expect = 2e-06
Identities = 60/236 (25%), Positives = 99/236 (41%), Gaps = 21/236 (8%)
Query: 95 RLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEG---GEVELSCLVPRSR 151
R+ D G Y C + + + + AP N V + V G G++ L C V +
Sbjct: 2359 RVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSV-EAE 2417
Query: 152 PAATLRWYRDRKELKGVSSSQ--ENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSG 209
PA + W+RD L+ + +Q E G+ ++ + D G C A+N A
Sbjct: 2418 PAPKITWHRDGIVLQEDAHTQFPERGRF------LQLQALSTADSGDYSCTARNAA---- 2467
Query: 210 HSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA 269
S + +++ PT R V T +L C G P P + W + L R+
Sbjct: 2468 GSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAP-LVSWRKDRVPLDPRS 2526
Query: 270 ---EAVGE-TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSV 321
E + E +L + +++ D G Y C ASN G R L V +P A+ + +++
Sbjct: 2527 PRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNL 2582
Score = 50.4 bits (119), Expect = 3e-06
Identities = 65/248 (26%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 89 IRLSDARLEDEGGYFCQLYT------EDTHHQI-ATLTVLVAPENPVVEVREQAVEGGEV 141
+R++ + + DEG Y C ++ D ++ A T+ + E V V E + V
Sbjct: 274 LRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHL----V 329
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDR--KDDGGIIIC 199
+L C R P + W++D L + KV + ++ R D G+ C
Sbjct: 330 QLLCEA-RGVPTPNITWFKDGALLP------TSTKVVYTRGGRQLQLGRAQSSDAGVYTC 382
Query: 200 EAQNQALPSGHSKQTQYVLDVQYSPT-----ARIHASQAVVREGDTLVLTCAVTGNPRPN 254
+A N K T+ LDV PT R + +AV G + L C G+P P
Sbjct: 383 KASNAV--GAAEKATR--LDVYVPPTIEGAGGRPYVVKAVA--GRPVALECVARGHPSPT 436
Query: 255 QIRWNRGN----ESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD 310
+ W+ ES R E G L L A +G Y+C AS+ G A Y + V
Sbjct: 437 -LSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 495
Query: 311 PGAVVEAQ 318
P ++ A+
Sbjct: 496 PPQLLVAE 503
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/195 (28%), Positives = 76/195 (38%), Gaps = 19/195 (9%)
Query: 113 HQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELK-GVSSS 171
H+ LTV +P + +AV EV L C P T+ W ++ + GVS+
Sbjct: 2746 HKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEAS-GIPRPTITWQKEGLNVATGVSTQ 2804
Query: 172 QENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHAS 231
G +A +D G +C A+N A S + L VQ P
Sbjct: 2805 VLPGGQLRIAHA------SPEDAGNYLCIAKNSA----GSAMGKTRLVVQVPPVIENGLP 2854
Query: 232 QAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERA-----EAVGETLTLPGLVSADN 286
EG L C G+P PN I W++ + + + GE L + L D
Sbjct: 2855 DLSTTEGSHAFLPCKARGSPEPN-ITWDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDA 2912
Query: 287 GTYTCEASNKHGHAR 301
GTYTC A N G AR
Sbjct: 2913 GTYTCTAENAVGRAR 2927
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/259 (24%), Positives = 106/259 (40%), Gaps = 42/259 (16%)
Query: 89 IRLSDARLEDEGGYFCQLYTE-----DTHHQIATLTVLVAPENPVVEVREQAVE---GGE 140
+++ +A+ ED G Y C + E +H + ++ ++P+ EV + V+
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNST 1465
Query: 141 VELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICE 200
+ L C + P T+RWY+D + + S Q G+ ++ + + D G +C
Sbjct: 1466 LTLEC-ESWAVPPPTIRWYKDGQPVTPSSRLQVLGE----GRLLQIQPTQVSDSGRYLCV 1520
Query: 201 AQNQALPSGHSKQTQYVLDV---------QYSPTARIHASQAVVREGDT----------L 241
A N A G Q VL +S I + + R G T
Sbjct: 1521 ATNVA---GEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577
Query: 242 VLTCAVTGNPRPNQIRWNRGNESLPERAEAV----GETLTLPGLVSADN-GTYTCEASNK 296
L C P P+ + W R ++ L E G L +P LV A+N G Y+C+ASN+
Sbjct: 1578 YLYCDTNAIPPPD-LTWYREDQPLSAGDEVSVLQGGRVLQIP-LVRAENAGRYSCKASNE 1635
Query: 297 HGHARALYVLVVYDPGAVV 315
G Y L+V P ++
Sbjct: 1636 VGEDWLHYELLVLTPPVIL 1654
Score = 47.8 bits (112), Expect = 2e-05
Identities = 62/253 (24%), Positives = 99/253 (39%), Gaps = 38/253 (15%)
Query: 72 LKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTED----THHQIATLTVLVAPENP 127
+KD L + + ++L D G Y C +E H Q+ + E P
Sbjct: 2250 MKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVM------EPP 2303
Query: 128 VVEVREQAVE-----GGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVAS 182
+E Q E G +EL C + P + W++D + L + ++
Sbjct: 2304 HIEDSGQPTELSLTPGAPMELLCDA-QGTPQPNITWHKDGQALTRLENNSR--------- 2353
Query: 183 TVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVV--REGDT 240
RV R D G+ C A++ P+G +++ + + VQ P V
Sbjct: 2354 --ATRVLRVRDAGLYTCLAES---PAGAIEKS-FRVRVQAPPNIVGPRGPRFVVGLAPGQ 2407
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAV----GETLTLPGLVSADNGTYTCEASNK 296
LVL C+V P P +I W+R L E A G L L L +AD+G Y+C A N
Sbjct: 2408 LVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2466
Query: 297 HGHARALYVLVVY 309
G + + ++
Sbjct: 2467 AGSTSVAFRVEIH 2479
Score = 45.4 bits (106), Expect = 9e-05
Identities = 47/190 (24%), Positives = 73/190 (38%), Gaps = 25/190 (13%)
Query: 152 PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHS 211
PA + W +DR L S E ++R + D G +C A N A G
Sbjct: 2509 PAPLVSWRKDRVPLDPRSPRFEI----LPEGSLRIQPVLAQDAGHYLCLASNSA---GSD 2561
Query: 212 KQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNES------- 264
+Q + L V P S + +L C +G+P+P + W G +
Sbjct: 2562 RQGRD-LRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQG 2620
Query: 265 ----LPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTS 320
LP A LT PG D+ + C SN+ G A LY + V+ P + + QT
Sbjct: 2621 AYRLLPSNALL----LTAPG--PQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTD 2674
Query: 321 VPYAIVGGIL 330
++ ++
Sbjct: 2675 FTVTMMAPVV 2684
Score = 45.1 bits (105), Expect = 1e-04
Identities = 59/268 (22%), Positives = 96/268 (35%), Gaps = 29/268 (10%)
Query: 89 IRLSDARLEDEGGYFC---QLYTEDTHH-----QIATLTVLVAPENPVVEV--REQAVEG 138
+++ ++ D G Y C + ED Q+ + V + E+ RE+ G
Sbjct: 1504 LQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARG 1563
Query: 139 GEVELSCLVPRSR----------PAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRV 188
G E +V + P L WYR+ + L S+ + V ++ +
Sbjct: 1564 GVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL----SAGDEVSVLQGGRVLQIPL 1619
Query: 189 DRKDDGGIIICEAQNQALPSG-HSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAV 247
R ++ G C+A N+ H + V T + + V T+ L C
Sbjct: 1620 VRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEEL-VEEVTVNASSTVSLQCPA 1678
Query: 248 TGNPRPNQIRWNRGNESLPERAEAV---GETLTLPGLVSADNGTYTCEASNKHGHARALY 304
GNP P G P V G+ L + AD +Y C A N+ G A L+
Sbjct: 1679 LGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLF 1738
Query: 305 VLVVYDPGAVVEAQTSVPYAIVGGILAL 332
L V P + AI+ ++L
Sbjct: 1739 TLRVQVPPRIAGLDLEQVTAILNSSVSL 1766
Score = 43.1 bits (100), Expect = 4e-04
Identities = 28/77 (36%), Positives = 40/77 (51%), Gaps = 6/77 (7%)
Query: 245 CAVTGNPRPNQIRWNRGNESLPERAE---AVGE--TLTLPGLVSADNGTYTCEASNKHGH 299
C G P+P Q+ W +G S P + AV E +L L + AD+G Y C+A+N+ G
Sbjct: 24 CGTHGTPKP-QVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS 82
Query: 300 ARALYVLVVYDPGAVVE 316
LVVY P ++ E
Sbjct: 83 TSRRAKLVVYVPPSIRE 99
Score = 40.0 bits (92), Expect = 0.004
Identities = 48/201 (23%), Positives = 84/201 (41%), Gaps = 21/201 (10%)
Query: 118 LTVLVAPE-----NPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQ 172
L+VLV PE +P+ + A + L C P A +RW+R + + +
Sbjct: 1153 LSVLVPPELIGDLDPLTNIT--AALHSPLTLLCEAMGIPPPA-IRWFRGEEPVSPGEDTY 1209
Query: 173 ENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQ 232
W + T ++ D G+ C A N+A G +++ + ++V P+ +
Sbjct: 1210 LLAGGWMLKMTQT----QEQDSGLYSCLASNEA---GEARRN-FSVEVLVPPSIENEDLE 1261
Query: 233 AVVR--EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSAD---NG 287
V++ +G T L C VTG+P+P + G A + L ++ A+ G
Sbjct: 1262 EVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAG 1321
Query: 288 TYTCEASNKHGHARALYVLVV 308
Y+C A+N G + L V
Sbjct: 1322 HYSCIAANAVGEKTKHFQLSV 1342
Score = 35.8 bits (81), Expect = 0.067
Identities = 33/120 (27%), Positives = 46/120 (38%), Gaps = 18/120 (15%)
Query: 216 YVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL---------- 265
Y + V PT + V +VLTC TG P P + W++ L
Sbjct: 2658 YQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSWSKAGAQLGARGSGYRVS 2716
Query: 266 PERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAI 325
P A +G+ L + G YTC A N G A +V + VV+ SV A+
Sbjct: 2717 PSGALEIGQALPIHA------GRYTCSARNSAGVAHK-HVFLTVQASPVVKPLPSVVRAV 2769
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 74.7 bits (182), Expect = 1e-13
Identities = 88/300 (29%), Positives = 123/300 (41%), Gaps = 30/300 (10%)
Query: 28 QTENVTVAEGGVAEITCRLH-QYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRR 86
Q ++ V+ G A + CR + +I +N AR RA + F PR
Sbjct: 69 QPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFPRI 128
Query: 87 VRIRLSDARLEDEGGYFC--QLYTEDTHHQIATLTVLV-------APENPVVEVREQAVE 137
V R + DEG Y C + Y + A+L V V +P N VV V E AV
Sbjct: 129 VHGRRARP---DEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVAVGEPAV- 184
Query: 138 GGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGII 197
L C+ PR P ++ W +D LK +E G++ + K D G+
Sbjct: 185 -----LECVPPRGHPEPSVSWRKDGARLK-----EEEGRITIRGGKLMMSHTLKSDAGMY 234
Query: 198 ICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIR 257
+C A N A G + + V P+ VV + C V G+P P ++R
Sbjct: 235 VCVASNMA---GERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPP-RLR 290
Query: 258 WNRGNESLPE-RAEAVGETLTLPGLVSA-DNGTYTCEASNKHGHARALYVLVVYDPGAVV 315
W + + LP R E + G VSA D GTYTC A N G A A L V+ P +V
Sbjct: 291 WRKEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLV 350
Score = 46.6 bits (109), Expect = 4e-05
Identities = 54/216 (25%), Positives = 91/216 (42%), Gaps = 16/216 (7%)
Query: 97 EDEGGYFCQLYTEDTHHQIA-TLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAT 155
EDEG Y C + + +L+V V P+ + A G V C + P
Sbjct: 319 EDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCET-KGNPPPA 377
Query: 156 LRWYRDRKE--LKGVSSSQENGKVWSVASTVRFRVD--RKDDGGIIICEAQNQA---LPS 208
+ W ++ + L S Q G+ +SV+ + + ++ D G +C+A + A L
Sbjct: 378 IFWQKEGSQVLLFPSQSLQPTGR-FSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAK 436
Query: 209 GHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLP-- 266
+ LD + A+Q +V G ++ L C VTGNP+P+ +RW + + L
Sbjct: 437 ALLEIKGASLDGLPPVILQGPANQTLVL-GSSVWLPCRVTGNPQPS-VRWKKDGQWLQGD 494
Query: 267 --ERAEAVGETLTLPGLVSADNGTYTCEASNKHGHA 300
+ TL + + D G Y+C A + G A
Sbjct: 495 DLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEA 530
>gi|94538343 sialic acid binding Ig-like lectin 8 [Homo sapiens]
Length = 499
Score = 74.3 bits (181), Expect = 2e-13
Identities = 99/362 (27%), Positives = 143/362 (39%), Gaps = 56/362 (15%)
Query: 49 YDGSIVVIQNPARQTLFFNGTRALKDERFQL-EEFSPRRVRIRLSDARLEDEGGYFCQL- 106
Y + V NP R+ +A RFQL + + + DAR D+G YF +L
Sbjct: 74 YQDAPVATNNPDREV------QAETQGRFQLLGDIWSNDCSLSIRDARKRDKGSYFFRLE 127
Query: 107 -------YTEDTHHQIATLTVLVAP--ENPVVEVREQAVEGGEVELSCLVPRSRPAAT-- 155
Y +++ L+V V P + + G L+C VP + T
Sbjct: 128 RGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGTLESGHSRNLTCSVPWACKQGTPP 187
Query: 156 -LRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQT 214
+ W G S S G + +S + +D G + C+ LP T
Sbjct: 188 MISWI-------GASVSSP-GPTTARSSVLTLTPKPQDHGTSLTCQV---TLPGTGVTTT 236
Query: 215 QYV-LDVQYSP---------------TARIHASQAVVREGDTLVLTCAVTGNPRPNQIRW 258
V LDV Y P TA + S V EG +L L CAV NP P ++ W
Sbjct: 237 STVRLDVSYPPWNLTMTVFQGDATASTALGNGSSLSVLEGQSLRLVCAVNSNP-PARLSW 295
Query: 259 NRGNESL-PERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEA 317
RG+ +L P R+ G L LP + D G +TC A N G L + + G
Sbjct: 296 TRGSLTLCPSRSSNPG-LLELPRVHVRDEGEFTCRAQNAQGSQHISLSLSLQNEGTGTSR 354
Query: 318 QTS-VPYAIVGGILA-LLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLN 375
S V A VGG A L FL C++ ++ S R+K + A+G+ + G +
Sbjct: 355 PVSQVTLAAVGGAGATALAFLSFCIIF-IIVRSCRKKSA---RPAAGVGDTGMEDAKAIR 410
Query: 376 GS 377
GS
Sbjct: 411 GS 412
>gi|11386199 poliovirus receptor-related 3 [Homo sapiens]
Length = 549
Score = 73.2 bits (178), Expect = 4e-13
Identities = 74/334 (22%), Positives = 133/334 (39%), Gaps = 31/334 (9%)
Query: 12 LLLWAAAAGPGAGQEVQTENVTVAEGGVAEITC--------------RLHQYDGSIVVIQ 57
LLL++ G AG + +VT G + C ++H V +
Sbjct: 46 LLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVH 105
Query: 58 NPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHH--QI 115
+P + + R + +S I L + D G Y C+ T +
Sbjct: 106 HPQ----YGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSS 161
Query: 116 ATLTVLVAPENPVVEVREQAVEGGE--VELSCLVPRSRPAATLRWYRDRKELKGVSSSQE 173
T+TVLV P +++ + ++GG V C+ +P A + W D E++ ++S
Sbjct: 162 TTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFP 221
Query: 174 NGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQA 233
N + ++ S + R G I C ++ AL + ++LD+QY+P +
Sbjct: 222 N-ETATIISQYKLFPTRFARGRRITCVVKHPALEK--DIRYSFILDIQYAPEVSVTGYDG 278
Query: 234 ---VVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSAD-NGTY 289
V R+G + L C NP P + W+R + P+ A TL ++ + +G Y
Sbjct: 279 NWFVGRKG--VNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVY 336
Query: 290 TCEASNKHGHARALYVLVVYDPGAVVEAQTSVPY 323
C+ +N G V+ + DP Q ++ +
Sbjct: 337 ICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQW 370
>gi|59939900 opioid binding protein/cell adhesion molecule-like
isoform b preproprotein [Homo sapiens]
Length = 338
Score = 72.0 bits (175), Expect = 8e-13
Identities = 79/307 (25%), Positives = 125/307 (40%), Gaps = 32/307 (10%)
Query: 30 ENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALK-DERFQLEEFSPRRVR 88
+NVTV +G A + C + D + + R T+ + G D R + +P +
Sbjct: 36 DNVTVRQGESATLRCTI---DDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYS 92
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAV--EGGEVELSCL 146
I + + + DEG Y C + T D H + + + ++V ++ + EG V L CL
Sbjct: 93 IMIQNVDVYDEGPYTCSVQT-DNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCL 151
Query: 147 VPRSRPAATLRW-YRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQA 205
RP T+ W + KE +G S E ++ + ++D G C A N
Sbjct: 152 AI-GRPEPTVTWRHLSVKEGQGFVSEDEYLEISDI---------KRDQSGEYECSALNDV 201
Query: 206 LPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL 265
K + V Y P A V G +L+C + P + +W + L
Sbjct: 202 AAPDVRKVK---ITVNYPPYIS-KAKNTGVSVGQKGILSCEASAVPMA-EFQWFKEETRL 256
Query: 266 PE-----RAEAVGE--TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQ 318
R E G TLT + D G YTC A+NK G+ A + +Y PGAV++
Sbjct: 257 ATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNA--SITLYGPGAVIDGV 314
Query: 319 TSVPYAI 325
S A+
Sbjct: 315 NSASRAL 321
>gi|4505505 opioid binding protein/cell adhesion molecule-like
isoform a preproprotein [Homo sapiens]
Length = 345
Score = 72.0 bits (175), Expect = 8e-13
Identities = 79/307 (25%), Positives = 125/307 (40%), Gaps = 32/307 (10%)
Query: 30 ENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALK-DERFQLEEFSPRRVR 88
+NVTV +G A + C + D + + R T+ + G D R + +P +
Sbjct: 43 DNVTVRQGESATLRCTI---DDRVTRVAWLNRSTILYAGNDKWSIDPRVIILVNTPTQYS 99
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAV--EGGEVELSCL 146
I + + + DEG Y C + T D H + + + ++V ++ + EG V L CL
Sbjct: 100 IMIQNVDVYDEGPYTCSVQT-DNHPKTSRVHLIVQVPPQIMNISSDITVNEGSSVTLLCL 158
Query: 147 VPRSRPAATLRW-YRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQA 205
RP T+ W + KE +G S E ++ + ++D G C A N
Sbjct: 159 AI-GRPEPTVTWRHLSVKEGQGFVSEDEYLEISDI---------KRDQSGEYECSALNDV 208
Query: 206 LPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL 265
K + V Y P A V G +L+C + P + +W + L
Sbjct: 209 AAPDVRKVK---ITVNYPPYIS-KAKNTGVSVGQKGILSCEASAVPMA-EFQWFKEETRL 263
Query: 266 PE-----RAEAVGE--TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQ 318
R E G TLT + D G YTC A+NK G+ A + +Y PGAV++
Sbjct: 264 ATGLDGMRIENKGRMSTLTFFNVSEKDYGNYTCVATNKLGNTNA--SITLYGPGAVIDGV 321
Query: 319 TSVPYAI 325
S A+
Sbjct: 322 NSASRAL 328
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 72.0 bits (175), Expect = 8e-13
Identities = 70/256 (27%), Positives = 103/256 (40%), Gaps = 30/256 (11%)
Query: 75 ERFQLEEFSPRRVRIRLSDARL------------EDEGGYFC--QLYTEDTHHQIATLTV 120
ER + ++ PR R+ L L DEG Y C + Y + + A+L V
Sbjct: 85 ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV 144
Query: 121 LVAPENPVVEVREQAVEGGEVE-LSCLVPRSRPAATLRWYRDRKEL--KGVSSSQENGKV 177
+ ++ + V GE L C PR P T+ W +D+ + K S GK+
Sbjct: 145 ALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKL 204
Query: 178 WSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVRE 237
+++T RK D G+ C N G L V PT VV E
Sbjct: 205 M-ISNT------RKSDAGMYTCVGTNMV---GERDSDPAELTVFERPTFLRRPINQVVLE 254
Query: 238 GDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGE--TLTLPGLVSADNGTYTCEASN 295
+ + C V G+P+P +RW + + LP + + TL + +S D GTY C A N
Sbjct: 255 EEAVEFRCQVQGDPQPT-VRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAEN 313
Query: 296 KHGHARALYVLVVYDP 311
+ G A L V P
Sbjct: 314 RVGKMEASATLTVRAP 329
Score = 59.7 bits (143), Expect = 4e-09
Identities = 61/237 (25%), Positives = 96/237 (40%), Gaps = 12/237 (5%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVP 148
+R+ DEG Y C + + + AP VV R+Q V G
Sbjct: 294 LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCET 353
Query: 149 RSRPAATLRWYRDRKE-LKGVSSSQENGKVWSVASTVRFRVD--RKDDGGIIICEAQNQA 205
+ P + W ++ + L + Q+ SV+ T + ++ D G IC+A A
Sbjct: 354 KGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVA 413
Query: 206 ---LPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
L + T + D + A+Q + +G T +L C TG+P P I W +
Sbjct: 414 GSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG-TALLKCKATGDPLP-VISWLKEG 471
Query: 263 ESLPER--AEAVGE--TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVV 315
+ P R + E TL + L +D GTYTC A++ G VL V + GA +
Sbjct: 472 FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATI 528
Score = 44.3 bits (103), Expect = 2e-04
Identities = 41/174 (23%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 137 EGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRF-RV----DRK 191
+G L+C RP T+ WY+D + ++ + ++ + ++ F R+ K
Sbjct: 60 KGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK 118
Query: 192 DDGGIIICEAQN---QALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTC-AV 247
D G +C A+N +A+ S + + D R + + VV G+ +L C
Sbjct: 119 PDEGSYVCVARNYLGEAVSRNASLEVALLRD-----DFRQNPTDVVVAAGEPAILECQPP 173
Query: 248 TGNPRPNQIRWNRGNESLPERAEAV---GETLTLPGLVSADNGTYTCEASNKHG 298
G+P P I W + + ++ E + G L + +D G YTC +N G
Sbjct: 174 RGHPEPT-IYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 226
Score = 32.7 bits (73), Expect = 0.57
Identities = 23/92 (25%), Positives = 34/92 (36%), Gaps = 14/92 (15%)
Query: 222 YSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL-PERAEAVGETLTLPG 280
+ P H S +V +G+ L C G P P I W + E + ++ + + LP
Sbjct: 45 FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 103
Query: 281 ------------LVSADNGTYTCEASNKHGHA 300
D G+Y C A N G A
Sbjct: 104 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEA 135
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 72.0 bits (175), Expect = 8e-13
Identities = 70/256 (27%), Positives = 103/256 (40%), Gaps = 30/256 (11%)
Query: 75 ERFQLEEFSPRRVRIRLSDARL------------EDEGGYFC--QLYTEDTHHQIATLTV 120
ER + ++ PR R+ L L DEG Y C + Y + + A+L V
Sbjct: 69 ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEV 128
Query: 121 LVAPENPVVEVREQAVEGGEVE-LSCLVPRSRPAATLRWYRDRKEL--KGVSSSQENGKV 177
+ ++ + V GE L C PR P T+ W +D+ + K S GK+
Sbjct: 129 ALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKL 188
Query: 178 WSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVRE 237
+++T RK D G+ C N G L V PT VV E
Sbjct: 189 M-ISNT------RKSDAGMYTCVGTNMV---GERDSDPAELTVFERPTFLRRPINQVVLE 238
Query: 238 GDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGE--TLTLPGLVSADNGTYTCEASN 295
+ + C V G+P+P +RW + + LP + + TL + +S D GTY C A N
Sbjct: 239 EEAVEFRCQVQGDPQPT-VRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAEN 297
Query: 296 KHGHARALYVLVVYDP 311
+ G A L V P
Sbjct: 298 RVGKMEASATLTVRAP 313
Score = 59.7 bits (143), Expect = 4e-09
Identities = 61/237 (25%), Positives = 96/237 (40%), Gaps = 12/237 (5%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVP 148
+R+ DEG Y C + + + AP VV R+Q V G
Sbjct: 278 LRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCET 337
Query: 149 RSRPAATLRWYRDRKE-LKGVSSSQENGKVWSVASTVRFRVD--RKDDGGIIICEAQNQA 205
+ P + W ++ + L + Q+ SV+ T + ++ D G IC+A A
Sbjct: 338 KGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVA 397
Query: 206 ---LPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN 262
L + T + D + A+Q + +G T +L C TG+P P I W +
Sbjct: 398 GSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDG-TALLKCKATGDPLP-VISWLKEG 455
Query: 263 ESLPER--AEAVGE--TLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVV 315
+ P R + E TL + L +D GTYTC A++ G VL V + GA +
Sbjct: 456 FTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATI 512
Score = 44.3 bits (103), Expect = 2e-04
Identities = 41/174 (23%), Positives = 74/174 (42%), Gaps = 19/174 (10%)
Query: 137 EGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRF-RV----DRK 191
+G L+C RP T+ WY+D + ++ + ++ + ++ F R+ K
Sbjct: 44 KGEPTTLNCKA-EGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSK 102
Query: 192 DDGGIIICEAQN---QALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTC-AV 247
D G +C A+N +A+ S + + D R + + VV G+ +L C
Sbjct: 103 PDEGSYVCVARNYLGEAVSRNASLEVALLRD-----DFRQNPTDVVVAAGEPAILECQPP 157
Query: 248 TGNPRPNQIRWNRGNESLPERAEAV---GETLTLPGLVSADNGTYTCEASNKHG 298
G+P P I W + + ++ E + G L + +D G YTC +N G
Sbjct: 158 RGHPEPT-IYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVG 210
Score = 32.7 bits (73), Expect = 0.57
Identities = 23/92 (25%), Positives = 34/92 (36%), Gaps = 14/92 (15%)
Query: 222 YSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESL-PERAEAVGETLTLPG 280
+ P H S +V +G+ L C G P P I W + E + ++ + + LP
Sbjct: 29 FPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT-IEWYKDGERVETDKDDPRSHRMLLPS 87
Query: 281 ------------LVSADNGTYTCEASNKHGHA 300
D G+Y C A N G A
Sbjct: 88 GSLFFLRIVHGRRSKPDEGSYVCVARNYLGEA 119
>gi|112789532 poliovirus receptor related 2 isoform delta precursor
[Homo sapiens]
Length = 538
Score = 71.2 bits (173), Expect = 1e-12
Identities = 90/396 (22%), Positives = 137/396 (34%), Gaps = 49/396 (12%)
Query: 9 WPLLLLWAAAAGPGAGQEVQTE---NVTVAEGGVAEITCRL------------------- 46
WPLLLL G Q+V+ + V GG E+ C L
Sbjct: 19 WPLLLLLLLETG---AQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDA 75
Query: 47 ----------HQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARL 96
H G P + L F K Q E + + L +
Sbjct: 76 PANHQNVAAFHPKMGPSFPSPKPGSERLSFVSA---KQSTGQDTEAELQDATLALHGLTV 132
Query: 97 EDEGGYFCQLYT--EDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAA 154
EDEG Y C+ T + + + L V+ P+N + + C+ RP A
Sbjct: 133 EDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPA 192
Query: 155 TLRWYRDRK-ELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQ 213
+ W E K S +V S + DG + C+ ++++
Sbjct: 193 RISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEE--PAL 250
Query: 214 TQYVLDVQYSPTARIHASQAVVREGDT-LVLTCAVTGNPRPNQIRWNRGNESLPERAEAV 272
L V+Y P I G T L+C V NP P W+ + + P A A
Sbjct: 251 IPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQ 310
Query: 273 GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYD-PGAVVEAQTSVPYAIVGGILA 331
G L + + S N T+ C +N G RA V+ V + P T I+GGI+A
Sbjct: 311 GSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATG---GIIGGIIA 367
Query: 332 LLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQG 367
++ + G++ C ++K L D +G
Sbjct: 368 AIIATAVAA-TGILICRQQRKEQTLQGAEEDEDLEG 402
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 71.2 bits (173), Expect = 1e-12
Identities = 56/244 (22%), Positives = 106/244 (43%), Gaps = 11/244 (4%)
Query: 86 RVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEV--REQAVEGGEVEL 143
R R+ + +A +ED G Y CQ Q AT+ + + + EV ++ +G + E+
Sbjct: 75 RSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQGEDAEV 134
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQN 203
C V S PA + W +E+ +S +N + ++ K D GI CE +
Sbjct: 135 VCRVSSS-PAPAVSWLYHNEEVTTIS---DNRFAMLANNNLQILNINKSDEGIYRCEGRV 190
Query: 204 QALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNE 263
+A + +++V + + + A G+ + +C +G+P P I W R +
Sbjct: 191 EARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP-AISWFRNGK 249
Query: 264 SLPERAEAV----GETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQT 319
+ E + + LT+ ++++D G Y C A+NK G L V+ +++ +
Sbjct: 250 LIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKN 309
Query: 320 SVPY 323
Y
Sbjct: 310 ETTY 313
Score = 53.1 bits (126), Expect = 4e-07
Identities = 76/315 (24%), Positives = 123/315 (39%), Gaps = 54/315 (17%)
Query: 21 PGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLE 80
P ++ N T G +CR GS PA + F NG ++E++ L+
Sbjct: 209 PAISMPQKSFNATAERGEEMTFSCRA---SGS----PEPAI-SWFRNGKLIEENEKYILK 260
Query: 81 EFSPRRVRIRLSDARLEDEGGYFCQLYTE-DTHHQIATLTVLVAPENPVVEVR-EQAVEG 138
+ + + + D G Y C+ + + A L V V P +++++ E E
Sbjct: 261 GSN---TELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPH--IIQLKNETTYEN 315
Query: 139 GEVELSCLVPRSRPAATLRWYR---------------DRKELKGVSSSQENGKVWSVAST 183
G+V L C P + W R R E+KG S S+
Sbjct: 316 GQVTLVCDA-EGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGS----------SS 364
Query: 184 VRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVL 243
+ + + D G CEA ++ GH K LD++Y+P + + EG+ + +
Sbjct: 365 LHIKDVKLSDSGRYDCEAASRI--GGHQKSMY--LDIEYAPKFISNQTIYYSWEGNPINI 420
Query: 244 TCAVTGNPRPNQIRWNRGNESLPER------AEAVGETLTLPGLVSADN--GTYTCEASN 295
+C V NP P I W R LP + + G + L ++DN G Y C A+N
Sbjct: 421 SCDVKSNP-PASIHWRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
Query: 296 KHGHARALYVLVVYD 310
G Y+L + D
Sbjct: 480 HIGTRFQEYILALAD 494
Score = 40.8 bits (94), Expect = 0.002
Identities = 48/204 (23%), Positives = 85/204 (41%), Gaps = 15/204 (7%)
Query: 27 VQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRR 86
+Q +N T E G + C + + F G ++L D R +++
Sbjct: 305 IQLKNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSL-DGRIEVKG-QHGS 362
Query: 87 VRIRLSDARLEDEGGYFCQLYTEDTHHQIAT-LTVLVAPENPVVEVREQAVEGGEVELSC 145
+ + D +L D G Y C+ + HQ + L + AP+ + + EG + +SC
Sbjct: 363 SSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPINISC 422
Query: 146 LVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRV--DRKDDGGIIICEAQN 203
V +S P A++ W RD+ L +++ N K +S + + +D G C A N
Sbjct: 423 DV-KSNPPASIHWRRDKLVLPAKNTT--NLKTYSTGRKMILEIAPTSDNDFGRYNCTATN 479
Query: 204 QALPSGHSKQTQYVL---DVQYSP 224
++ +Y+L DV SP
Sbjct: 480 HI----GTRFQEYILALADVPSSP 499
Score = 28.9 bits (63), Expect = 8.3
Identities = 23/90 (25%), Positives = 36/90 (40%), Gaps = 10/90 (11%)
Query: 228 IHASQAVVREGDTLVLTCAVTGNPRPNQIRWNR-------GNESLPERAEAVGETLTLPG 280
I S+ + G++ TC G P I W + + + E V LT+
Sbjct: 25 ISLSKVELSVGESKFFTCTAIGEPE--SIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 82
Query: 281 LVSADNGTYTCEASNKHGHAR-ALYVLVVY 309
D G Y C+A++ G + A VL +Y
Sbjct: 83 ANIEDAGIYRCQATDAKGQTQEATVVLEIY 112
>gi|222136611 poliovirus receptor-related 4 [Homo sapiens]
Length = 510
Score = 70.9 bits (172), Expect = 2e-12
Identities = 82/314 (26%), Positives = 132/314 (42%), Gaps = 28/314 (8%)
Query: 89 IRLSDARLEDEGGYFCQLYT--EDTHHQIATLTVLVAPE---NPVVEVREQAVEGGEVEL 143
+ L +A DEG Y C++ T + L VLV P NP + E +G +
Sbjct: 112 VLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEG--QGLTLAA 169
Query: 144 SCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRV--DRKDDGGIIICEA 201
SC S PA ++ W E+KG +SS+ S A T F + R +G + C
Sbjct: 170 SCTAEGS-PAPSVTW---DTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVV 225
Query: 202 QNQALPSGHSKQTQYVLDVQYSPTARIHASQA-----VVREGDTLVLTCAVTGNPRPNQI 256
+ L ++ ++L V + A + + + REG +L C G P P+
Sbjct: 226 SHPGLLQ--DQRITHILHVSFLAEASVRGLEDQNLWHIGREG--AMLKCLSEGQPPPSY- 280
Query: 257 RWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVE 316
W R + LP G+TL P L + +G Y C SN+ + + V DP
Sbjct: 281 NWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSG 340
Query: 317 AQTSVPYA--IVGGILALLVFLIICVLVGMVWCSVRQKGSYLT---HEASGLDEQGEARE 371
Q + A +V G++A L+F ++ V+V ++ R+K +T E L + R
Sbjct: 341 KQVDLVSASVVVVGVIAALLFCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRR 400
Query: 372 AFLNGSDGHKRKEE 385
+ +D + EE
Sbjct: 401 LHSHHTDPRSQPEE 414
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 70.1 bits (170), Expect = 3e-12
Identities = 72/261 (27%), Positives = 107/261 (40%), Gaps = 28/261 (10%)
Query: 88 RIRLSDARLEDEGGYFCQLYTEDTHHQIATLTV-LVAPENPVVEVREQAVEGGEVE---- 142
R+ +S+ D G Y C+ + + A T L E P ++ EVE
Sbjct: 346 RLTISNPTSADTGPYVCEAALPGSAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVD 405
Query: 143 LSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVD--RKDDGGIIICE 200
+ C P TL+WY+D +S S+ + V ++ R+ R +D GI C
Sbjct: 406 IGCQA-MGVPLPTLQWYKD-----AISISRLQNPRYKVLASGGLRIQKLRPEDSGIFQCF 459
Query: 201 AQNQALPSGHSKQTQYVLDV-QYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWN 259
A N+ G QT LDV +P V +G T +L C V+G P+P I W
Sbjct: 460 ASNE----GGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKP-AITWK 514
Query: 260 RGNESLPERAEAVGETLTLP--GLVSA-----DNGTYTCEASNKHGHARALYVLVVYDPG 312
R N L + + + L GL A D G YTC A+N G A L V++
Sbjct: 515 RENHILASGSVRIPRFMLLESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTVWNRT 574
Query: 313 AVVEAQTSVPYAIVGGILALL 333
++V + ++ G A L
Sbjct: 575 SIVHPPED--HVVIKGTTATL 593
Score = 40.4 bits (93), Expect = 0.003
Identities = 45/197 (22%), Positives = 79/197 (40%), Gaps = 27/197 (13%)
Query: 132 REQAVEGGEVELSCLVPRSRPAATLRWYRDRKEL---KGVSSSQENGKVWSVASTVRFRV 188
R+ +G L+ L S P + W+R+ ++ ++ + EN V +T
Sbjct: 199 RKTVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTT----- 253
Query: 189 DRKDDGGIIICEAQNQALPSGHSKQTQYV-----LDV----QYSPTARIH-ASQAVVREG 238
D G +A N+ +G +K + ++ DV +PT + +++VV
Sbjct: 254 ---SDAGAYYVQAVNEK--NGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
Query: 239 DTLVLTCAVTGNPRPN-QIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAS--- 294
L C + P + + W R + + G LT+ SAD G Y CEA+
Sbjct: 309 SETTLECIASARPVEDLSVTWKRNGVRITSGLHSFGRRLTISNPTSADTGPYVCEAALPG 368
Query: 295 NKHGHARALYVLVVYDP 311
+ ARA L + +P
Sbjct: 369 SAFEPARATAFLFIIEP 385
Score = 33.1 bits (74), Expect = 0.44
Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 3/62 (4%)
Query: 237 EGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNK 296
EG+ LVLTC G+ P + +W R + L + +P L D G Y C N+
Sbjct: 118 EGNRLVLTCLAEGS-WPLEFKWMRDDSELTTYSSEY--KYIIPSLQKLDAGFYRCVVRNR 174
Query: 297 HG 298
G
Sbjct: 175 MG 176
Score = 32.3 bits (72), Expect = 0.75
Identities = 62/260 (23%), Positives = 103/260 (39%), Gaps = 37/260 (14%)
Query: 89 IRLSDARLEDEGGYFCQLYTEDTHHQIATLTVL----VAPENPVVEVREQAVEGGEVELS 144
+R+ R ED G + C + + +I T T L +AP V +G L
Sbjct: 443 LRIQKLRPEDSGIFQC--FASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILR 500
Query: 145 CLVPRSRPAATLRWYRDRKELKGVSSS------QENGKVWSVASTVRFRVDRKDDGGIII 198
C V + P + W R+ L S E+G + ++ D G
Sbjct: 501 CEVSGA-PKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQ-------DAGNYT 552
Query: 199 CEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQA-VVREGDTLVLTCAVTGNPRPN-QI 256
C A N + S L V ++ T+ +H + VV +G T L C T +PR + +
Sbjct: 553 CYAAN----TEGSLNASATLTV-WNRTSIVHPPEDHVVIKGTTATLHCGATHDPRVSLRY 607
Query: 257 RWNRGNESL-PERAEAV----GETLTLPGLVSADNGTYTCEASNKHGH----ARALYVLV 307
W + N +L P + +L + S D G Y+CE ++ G+ AR + +
Sbjct: 608 VWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSRMARLEVIEL 667
Query: 308 VYDP-GAVVEAQTSVPYAIV 326
+ P +V +S +A+V
Sbjct: 668 PHSPQNLLVSPNSSHSHAVV 687
>gi|31543106 basal cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 628
Score = 70.1 bits (170), Expect = 3e-12
Identities = 100/371 (26%), Positives = 155/371 (41%), Gaps = 55/371 (14%)
Query: 34 VAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSD 93
V EG ++ CR DGS P+ + F L+DE+ ++ + + L
Sbjct: 281 VREGDTVQLLCR---GDGS------PSPEYTLFR----LQDEQEEVLNVNLEG-NLTLEG 326
Query: 94 ARLEDEGGYFCQLYTEDTHHQIA---TLTVLVAPENPVVEVREQAVEGGEVELSCLVPRS 150
G Y C++ D + TL + VA +P+ E+ E V + S +V S
Sbjct: 327 VTRGQSGTYGCRVEDYDAADDVQLSKTLELRVAYLDPL-ELSEGKVLSLPLNSSAVVNCS 385
Query: 151 ---RPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALP 207
P LRW +D S+ +G + S++S + F D G +CEA +P
Sbjct: 386 VHGLPTPALRWTKD-------STPLGDGPMLSLSS-ITF-----DSNGTYVCEASLPTVP 432
Query: 208 SGHSKQTQYVLDVQYSP---TARIHA-SQAVVREGDTLVLTCAVTGNPRPNQIRWNRGN- 262
S+ + L VQ SP TA I + REGD + L C+ G+P P ++ W++
Sbjct: 433 V-LSRTQNFTLLVQGSPELKTAEIEPKADGSWREGDEVTLICSARGHPDP-KLSWSQLGG 490
Query: 263 ---ESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQT 319
E +P R V +LTL + +CEASN HG+ R ++ P
Sbjct: 491 SPAEPIPGRQGWVSSSLTLKVTSALSRDGISCEASNPHGNKRHVFHFGTVSPQTSQAGVA 550
Query: 320 SVPYAIVGGILALLVFLIICV--LVGMVWCSVRQKGS------YLTHEASGLDEQGEARE 371
+ A+ G+L L+V + CV G R+KG+ L+H S EQ E
Sbjct: 551 VMAVAVSVGLLLLVVAVFYCVRRKGGPCCRQRREKGAPPPGEPGLSHSGS---EQPEQTG 607
Query: 372 AFLNGSDGHKR 382
+ G+ G R
Sbjct: 608 LLMGGASGGAR 618
Score = 57.0 bits (136), Expect = 3e-08
Identities = 63/235 (26%), Positives = 97/235 (41%), Gaps = 29/235 (12%)
Query: 88 RIRLSDARLEDEGGYFCQLYT--EDTHHQIATLTVLVAPENPVVEVRE---QAVEGGEVE 142
R+ L++A++ DE Y C + T A L V PE V + +E E
Sbjct: 109 RLVLAEAQVGDERDYVCVVRAGAAGTAEATARLNVFAKPEATEVSPNKGTLSVMEDSAQE 168
Query: 143 LS-CLVPRSRPAATLRWYRDRKEL--------KGVSSS---QENGKVWSVASTVRFRVDR 190
++ C PA + WYR+ + L +G +S +E + S+ ST+ R+ R
Sbjct: 169 IATCNSRNGNPAPKITWYRNGQRLEVPVEMNPEGYMTSRTVREASGLLSLTSTLYLRL-R 227
Query: 191 KDDGGIIICEAQNQALPSG-HSK--QTQYVLDVQYSPTARIH-------ASQAVVREGDT 240
KDD A + +LP G H + + L + Y PT + VREGDT
Sbjct: 228 KDDRDASFHCAAHYSLPEGRHGRLDSPTFHLTLHY-PTEHVQFWVGSPSTPAGWVREGDT 286
Query: 241 LVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASN 295
+ L C G+P P + +E + LTL G+ +GTY C +
Sbjct: 287 VQLLCRGDGSPSPEYTLFRLQDEQEEVLNVNLEGNLTLEGVTRGQSGTYGCRVED 341
>gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
Length = 646
Score = 69.7 bits (169), Expect = 4e-12
Identities = 75/311 (24%), Positives = 131/311 (42%), Gaps = 42/311 (13%)
Query: 18 AAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQ----NPARQTLFFNGTRALK 73
A PG ++ E V V G A + C L Q G++ + + ++TL F +
Sbjct: 22 AGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQG 81
Query: 74 -------DERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPEN 126
++R L++ R + L+ +DE + CQ + L V APE
Sbjct: 82 QSEPGEYEQRLSLQD---RGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEE 138
Query: 127 PVVEVREQAVEGGEVE----LSCLVPRSRPAATLRWYRDRKELKG------VSSSQ--EN 174
P ++V + E +C+ P + WY++ + LK + SSQ E+
Sbjct: 139 PNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVES 198
Query: 175 GKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSG-HSKQTQYVLDVQYSPTARIHASQ- 232
++++ S ++ ++ ++D CE N LPSG H K+++ V + PT ++
Sbjct: 199 SGLYTLQSILKAQLVKEDKDAQFYCEL-NYRLPSGNHMKESREVTVPVFYPTEKVWLEVE 257
Query: 233 --AVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYT 290
+++EGD + + C GNP P+ ++ N P EA ET + DNG
Sbjct: 258 PVGMLKEGDRVEIRCLADGNPPPH-FSISKQN---PSTREAEEET-------TNDNGVLV 306
Query: 291 CEASNKHGHAR 301
E + K R
Sbjct: 307 LEPARKEHSGR 317
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/231 (25%), Positives = 91/231 (39%), Gaps = 38/231 (16%)
Query: 91 LSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPE----NPVVEVR-----EQAVEGGEV 141
L AR E G Y CQ DT +++L P+ N V +VR + EG +
Sbjct: 307 LEPARKEHSGRYECQGLDLDT-----MISLLSEPQELLVNYVSDVRVSPAAPERQEGSSL 361
Query: 142 ELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEA 201
L+C S+ +W R+ E G+V ++ +++ GG C A
Sbjct: 362 TLTCEAESSQDLE-FQWLRE-----------ETGQVLERGPVLQLHDLKREAGGGYRCVA 409
Query: 202 QNQALPSGHSKQTQYVLDVQYSPTARIHASQAV-VREGDTLVLTCAVTGNPRPNQIRWN- 259
++P +TQ V + P + V V+E L L+C +G+PRP I WN
Sbjct: 410 SVPSIPG--LNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPT-ISWNV 466
Query: 260 ----RGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVL 306
+ P+R + L P L+ C ASN G ++ L
Sbjct: 467 NGTASEQDQDPQRVLSTLNVLVTPELLETG---VECTASNDLGKNTSILFL 514
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,476,830
Number of Sequences: 37866
Number of extensions: 691272
Number of successful extensions: 4151
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 271
Number of HSP's that attempted gapping in prelim test: 2034
Number of HSP's gapped (non-prelim): 1508
length of query: 388
length of database: 18,247,518
effective HSP length: 104
effective length of query: 284
effective length of database: 14,309,454
effective search space: 4063884936
effective search space used: 4063884936
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.