Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 216548378

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
         (927 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]            1886   0.0  
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]            1866   0.0  
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]            1860   0.0  
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            110   5e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            110   5e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            110   5e-24
gi|26665869 WD repeat domain 51B [Homo sapiens]                       101   3e-21
gi|32189425 WD repeat domain 69 [Homo sapiens]                        100   5e-21
gi|113865883 WD repeat domain 38 [Homo sapiens]                        96   2e-19
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    95   3e-19
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    95   3e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     92   3e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    92   3e-18
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]          86   2e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     84   8e-16
gi|23199987 WD repeat domain 5B [Homo sapiens]                         84   8e-16
gi|16554629 WD repeat domain 5 [Homo sapiens]                          83   1e-15
gi|16554627 WD repeat domain 5 [Homo sapiens]                          83   1e-15
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    83   1e-15
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]          81   5e-15
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...    80   7e-15
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...    78   3e-14
gi|13376840 WD repeat domain 61 [Homo sapiens]                         77   7e-14
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    76   1e-13
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...    74   6e-13
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...    74   6e-13
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...    74   6e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    72   2e-12
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    70   1e-11
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    69   2e-11

>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
          Length = 927

 Score = 1886 bits (4886), Expect = 0.0
 Identities = 927/927 (100%), Positives = 927/927 (100%)

Query: 1   MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
           MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
Sbjct: 1   MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60

Query: 61  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHVRFLFLKLEFT 120
           WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHVRFLFLKLEFT
Sbjct: 61  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHVRFLFLKLEFT 120

Query: 121 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 180
           MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA
Sbjct: 121 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 180

Query: 181 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 240
           EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC
Sbjct: 181 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 240

Query: 241 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 300
           GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP
Sbjct: 241 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 300

Query: 301 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 360
           YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV
Sbjct: 301 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 360

Query: 361 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 420
           QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA
Sbjct: 361 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 420

Query: 421 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 480
           KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT
Sbjct: 421 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 480

Query: 481 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 540
           EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT
Sbjct: 481 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 540

Query: 541 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 600
           HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK
Sbjct: 541 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 600

Query: 601 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 660
           SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV
Sbjct: 601 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 660

Query: 661 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 720
           RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR
Sbjct: 661 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 720

Query: 721 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 780
           DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG
Sbjct: 721 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 780

Query: 781 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 840
           SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG
Sbjct: 781 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 840

Query: 841 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 900
           RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI
Sbjct: 841 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 900

Query: 901 QCRWHTQDLSFLSSSADRTVTLWTYNG 927
           QCRWHTQDLSFLSSSADRTVTLWTYNG
Sbjct: 901 QCRWHTQDLSFLSSSADRTVTLWTYNG 927


>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
          Length = 920

 Score = 1866 bits (4834), Expect = 0.0
 Identities = 920/927 (99%), Positives = 920/927 (99%), Gaps = 7/927 (0%)

Query: 1   MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
           MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
Sbjct: 1   MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60

Query: 61  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHVRFLFLKLEFT 120
           WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQH       LEFT
Sbjct: 61  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQH-------LEFT 113

Query: 121 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 180
           MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA
Sbjct: 114 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 173

Query: 181 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 240
           EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC
Sbjct: 174 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 233

Query: 241 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 300
           GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP
Sbjct: 234 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 293

Query: 301 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 360
           YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV
Sbjct: 294 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 353

Query: 361 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 420
           QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA
Sbjct: 354 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 413

Query: 421 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 480
           KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT
Sbjct: 414 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 473

Query: 481 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 540
           EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT
Sbjct: 474 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 533

Query: 541 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 600
           HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK
Sbjct: 534 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 593

Query: 601 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 660
           SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV
Sbjct: 594 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 653

Query: 661 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 720
           RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR
Sbjct: 654 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 713

Query: 721 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 780
           DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG
Sbjct: 714 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 773

Query: 781 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 840
           SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG
Sbjct: 774 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 833

Query: 841 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 900
           RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI
Sbjct: 834 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 893

Query: 901 QCRWHTQDLSFLSSSADRTVTLWTYNG 927
           QCRWHTQDLSFLSSSADRTVTLWTYNG
Sbjct: 894 QCRWHTQDLSFLSSSADRTVTLWTYNG 920


>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
          Length = 919

 Score = 1860 bits (4818), Expect = 0.0
 Identities = 919/927 (99%), Positives = 919/927 (99%), Gaps = 8/927 (0%)

Query: 1   MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
           MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
Sbjct: 1   MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60

Query: 61  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHVRFLFLKLEFT 120
           WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQH       LEFT
Sbjct: 61  WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQH-------LEFT 113

Query: 121 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 180
           MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA
Sbjct: 114 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 173

Query: 181 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 240
           EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC
Sbjct: 174 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 233

Query: 241 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 300
           GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP
Sbjct: 234 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 293

Query: 301 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 360
           YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV
Sbjct: 294 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 353

Query: 361 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 420
           QNLSRSLMLENTECHSIYEESPER DTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA
Sbjct: 354 QNLSRSLMLENTECHSIYEESPER-DTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 412

Query: 421 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 480
           KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT
Sbjct: 413 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 472

Query: 481 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 540
           EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT
Sbjct: 473 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 532

Query: 541 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 600
           HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK
Sbjct: 533 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 592

Query: 601 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 660
           SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV
Sbjct: 593 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 652

Query: 661 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 720
           RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR
Sbjct: 653 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 712

Query: 721 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 780
           DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG
Sbjct: 713 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 772

Query: 781 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 840
           SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG
Sbjct: 773 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 832

Query: 841 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 900
           RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI
Sbjct: 833 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 892

Query: 901 QCRWHTQDLSFLSSSADRTVTLWTYNG 927
           QCRWHTQDLSFLSSSADRTVTLWTYNG
Sbjct: 893 QCRWHTQDLSFLSSSADRTVTLWTYNG 919


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  110 bits (276), Expect = 5e-24
 Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)

Query: 657 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 716
           +P  R  R   HK ++ CV +SP G LLA+GS DK V++        N  G    F  H 
Sbjct: 11  KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 65

Query: 717 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 775
            T+R + F     S G   ++A + D  +      R + L +LS H   +  A ++  G 
Sbjct: 66  ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120

Query: 776 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 835
           +I S S DKTV+ WD     CV     ++   G  V  V   PSG  +A    D++  ++
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176

Query: 836 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 894
           D+R  R++Q Y  HS+ V  + F P  +YL+T S D  +K+ DL +G L     +  +  
Sbjct: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 231

Query: 895 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
           H+       +      F S  +D  V +W  N
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)

Query: 616 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 675
           AV  V F P+G L A GS  KT+R+   P+V   S        V R      H  ++  V
Sbjct: 25  AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 71

Query: 676 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 735
            +   GQ   T S+DK VKV   + +           S H   +R   F       G ++
Sbjct: 72  HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 122

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 794
           +SA + D  +   D    + +H+   H G +  + +  SG  IA+   D TV+ WD+R  
Sbjct: 123 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181

Query: 795 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 854
             ++     +    +AV  ++  PSG  L T   DS+  + D+  GR++ + H H     
Sbjct: 182 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237

Query: 855 SVRFSPGAHYLLTGSYDMKIKV 876
           +V FS    Y  +G  D ++ V
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMV 259



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)

Query: 829 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYD--MKIKVTDLQGDLTKQ 886
           DS  M++ ++       +  H   V  V FSP  H L +GS D  ++I V +++G+ T  
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-- 59

Query: 887 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
               V   H   V    + +   SF+++S D+TV +W
Sbjct: 60  ----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  110 bits (276), Expect = 5e-24
 Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)

Query: 657 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 716
           +P  R  R   HK ++ CV +SP G LLA+GS DK V++        N  G    F  H 
Sbjct: 49  KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 103

Query: 717 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 775
            T+R + F     S G   ++A + D  +      R + L +LS H   +  A ++  G 
Sbjct: 104 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158

Query: 776 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 835
           +I S S DKTV+ WD     CV     ++   G  V  V   PSG  +A    D++  ++
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214

Query: 836 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 894
           D+R  R++Q Y  HS+ V  + F P  +YL+T S D  +K+ DL +G L     +  +  
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 269

Query: 895 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
           H+       +      F S  +D  V +W  N
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)

Query: 616 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 675
           AV  V F P+G L A GS  KT+R+   P+V   S        V R      H  ++  V
Sbjct: 63  AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 109

Query: 676 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 735
            +   GQ   T S+DK VKV   + +           S H   +R   F       G ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 160

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 794
           +SA + D  +   D    + +H+   H G +  + +  SG  IA+   D TV+ WD+R  
Sbjct: 161 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219

Query: 795 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 854
             ++     +    +AV  ++  PSG  L T   DS+  + D+  GR++ + H H     
Sbjct: 220 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 855 SVRFSPGAHYLLTGSYDMKIKV 876
           +V FS    Y  +G  D ++ V
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMV 297



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 8/122 (6%)

Query: 804 FHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH 863
           F G   AV  V    + + LA+G  DS  M++ ++       +  H   V  V FSP  H
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 864 YLLTGSYD--MKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT 921
            L +GS D  ++I V +++G+ T      V   H   V    + +   SF+++S D+TV 
Sbjct: 75  LLASGSRDKTVRIWVPNVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128

Query: 922 LW 923
           +W
Sbjct: 129 VW 130


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  110 bits (276), Expect = 5e-24
 Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)

Query: 657 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 716
           +P  R  R   HK ++ CV +SP G LLA+GS DK V++        N  G    F  H 
Sbjct: 49  KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 103

Query: 717 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 775
            T+R + F     S G   ++A + D  +      R + L +LS H   +  A ++  G 
Sbjct: 104 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158

Query: 776 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 835
           +I S S DKTV+ WD     CV     ++   G  V  V   PSG  +A    D++  ++
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214

Query: 836 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 894
           D+R  R++Q Y  HS+ V  + F P  +YL+T S D  +K+ DL +G L     +  +  
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 269

Query: 895 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
           H+       +      F S  +D  V +W  N
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301



 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)

Query: 616 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 675
           AV  V F P+G L A GS  KT+R+   P+V   S        V R      H  ++  V
Sbjct: 63  AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 109

Query: 676 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 735
            +   GQ   T S+DK VKV   + +           S H   +R   F       G ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 160

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 794
           +SA + D  +   D    + +H+   H G +  + +  SG  IA+   D TV+ WD+R  
Sbjct: 161 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219

Query: 795 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 854
             ++     +    +AV  ++  PSG  L T   DS+  + D+  GR++ + H H     
Sbjct: 220 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275

Query: 855 SVRFSPGAHYLLTGSYDMKIKV 876
           +V FS    Y  +G  D ++ V
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMV 297



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 8/122 (6%)

Query: 804 FHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH 863
           F G   AV  V    + + LA+G  DS  M++ ++       +  H   V  V FSP  H
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 864 YLLTGSYD--MKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT 921
            L +GS D  ++I V +++G+ T      V   H   V    + +   SF+++S D+TV 
Sbjct: 75  LLASGSRDKTVRIWVPNVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128

Query: 922 LW 923
           +W
Sbjct: 129 VW 130


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  101 bits (252), Expect = 3e-21
 Identities = 79/273 (28%), Positives = 123/273 (45%), Gaps = 23/273 (8%)

Query: 657 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKV-LPFNAETCNATGPDLEFSMH 715
           +P  R  R   HK  +  V +SP G LLA+ S D+ V++ +P      +  G   EF  H
Sbjct: 48  KPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIP------DKRGKFSEFKAH 101

Query: 716 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSG 774
              +R + F     S     ++  + D +I      R + L++L  HT  +  A ++  G
Sbjct: 102 TAPVRSVDF-----SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDG 156

Query: 775 WMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCML 834
            +I S S+DKT++ WD     CV      F  +      V  +PSG  +A+   D +  +
Sbjct: 157 RLIVSCSEDKTIKIWDTTNKQCVN----NFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212

Query: 835 YDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD-LQGDLTKQLPIMVVG 893
           +D+R  +++Q Y  HS  V  + F P  +YL+T S D  +K+ D L+G L     I  + 
Sbjct: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRL-----IYTLQ 267

Query: 894 EHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
            H   V    +      F S  AD  V LW  N
Sbjct: 268 GHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 68/279 (24%), Positives = 104/279 (37%), Gaps = 57/279 (20%)

Query: 603 KQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRF 662
           +Q    ++   T  VR   F P G L    S  KT+++             T KQ V  F
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW----------DTTNKQCVNNF 182

Query: 663 KRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDL 722
             +    G    V ++P G  +A+  +D+ VKV                + +H G +  +
Sbjct: 183 SDS---VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ-----HYQVHSGGVNCI 234

Query: 723 AFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGS 781
           +F       G  LI+A + D  +   D   G+ ++ L GHTG +  + ++  G + ASG 
Sbjct: 235 SF----HPSGNYLITA-SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289

Query: 782 QDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGR 841
            D  V  W        R      H  G          + R L     DS   L DI    
Sbjct: 290 ADTQVLLW--------RTNFDELHCKGL---------TKRNLKRLHFDSPPHLLDI---- 328

Query: 842 MVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 880
             ++ HPH   V +V  +P            K++V DLQ
Sbjct: 329 YPRTPHPHEEKVETVEINP------------KLEVIDLQ 355



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 30/123 (24%), Positives = 57/123 (46%), Gaps = 8/123 (6%)

Query: 804 FHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH 863
           F G  +A+ S+ + P+G+ LAT   D+  ML++ +       Y  H   V SV+FSP  +
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73

Query: 864 YLLTGSYDMKIK--VTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT 921
            L + S D  ++  + D +G  ++         H   V    +        ++S D+++ 
Sbjct: 74  LLASASRDRTVRLWIPDKRGKFSE------FKAHTAPVRSVDFSADGQFLATASEDKSIK 127

Query: 922 LWT 924
           +W+
Sbjct: 128 VWS 130


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  100 bits (250), Expect = 5e-21
 Identities = 86/321 (26%), Positives = 140/321 (43%), Gaps = 38/321 (11%)

Query: 608 INILEDTQ-AVRAVAFH-PAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRN 665
           +N LE  +  V A+AF+ P G   A GS  KT ++ +          ET K     +   
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV---------ETGKC----YHTF 173

Query: 666 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV--LPFNAETCNATGPDLEFSMHDGTIRDLA 723
           + H   I C++++P   L+ATGS D   K+  +    E     G       H   I  L+
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG-------HSAEIISLS 226

Query: 724 FMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQ 782
           F     SG  I+   G+ D  +   D   G+ ++ L GH   I  A + W   +I +GS 
Sbjct: 227 FNT---SGDRII--TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSM 281

Query: 783 DKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRM 842
           DKT + WD     CV     T  G    +     D +G+L+AT   D +  ++     + 
Sbjct: 282 DKTCKLWDATNGKCV----ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337

Query: 843 VQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQC 902
           +     H  ++  + F+P  ++LLTGS D   ++ D Q   T Q  + V+  H D++  C
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ---TGQC-LQVLEGHTDEIFSC 393

Query: 903 RWHTQDLSFLSSSADRTVTLW 923
            ++ +    ++ S D T  +W
Sbjct: 394 AFNYKGNIVITGSKDNTCRIW 414



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 12/197 (6%)

Query: 729 ESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTG--HILALYTWSGWMIASGSQDKTV 786
           +SG   +  +    C ++  D   G+ L+ L GH    + +A     G  IA+GS DKT 
Sbjct: 102 KSGSCFITGSYDRTCKLW--DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC 159

Query: 787 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 846
           + W +    C      TF G  + +  ++ +P   L+ATG  D++  L+DI+ G  V + 
Sbjct: 160 KLWSVETGKCYH----TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215

Query: 847 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHT 906
             HS+++ S+ F+     ++TGS+D  + V D   D  +++ I++   H  ++    ++ 
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWD--ADTGRKVNILI--GHCAEISSASFNW 271

Query: 907 QDLSFLSSSADRTVTLW 923
                L+ S D+T  LW
Sbjct: 272 DCSLILTGSMDKTCKLW 288



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 27/114 (23%), Positives = 50/114 (43%), Gaps = 5/114 (4%)

Query: 811 VASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRF-SPGAHYLLTGS 869
           + +VA++ SG    TG  D +C L+D   G  + +   H + V ++ F +P    + TGS
Sbjct: 95  LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154

Query: 870 YDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           +D   K+  ++              H  +++   ++ Q     + S D T  LW
Sbjct: 155 FDKTCKLWSVETGKCYH----TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 65/213 (30%), Positives = 104/213 (48%), Gaps = 12/213 (5%)

Query: 712 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALY 770
           F  H G +   AF       G +L++     C +Y  + + GQ L  L GHTG +    +
Sbjct: 17  FGQHGGEVNSSAF----SPDGQMLLTGSEDGC-VYGWETRSGQLLWRLGGHTGPVKFCRF 71

Query: 771 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 830
           +  G + AS S D TVR WD+    C+RV+     G   +V +V+  P  R LA+G  D 
Sbjct: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVL----KGHQRSVETVSFSPDSRQLASGGWDK 127

Query: 831 SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 890
             ML+D++ G+M++    H   ++S  FSP  + L TGS+D  + + DL+  +T  +   
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR-MVTPAVSHQ 186

Query: 891 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
            +  H    I C  ++      S S D+T+ +W
Sbjct: 187 ALEGHSAN-ISCLCYSASGLLASGSWDKTIHIW 218



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 13/212 (6%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H G +    +SP G L A+ S D  V++       C           H  ++  ++F   
Sbjct: 62  HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRV-----LKGHQRSVETVSF--S 114

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 786
           P+S     +++G  D  +   D Q GQ L  L GH   I +  ++ +   +A+GS D TV
Sbjct: 115 PDSRQ---LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171

Query: 787 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 846
             WDLR+ +   V      G  + ++ +    SG LLA+G  D +  ++      ++   
Sbjct: 172 HIWDLRMVTPA-VSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL 229

Query: 847 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
             H + V+S+ FSP   +L +  Y   +KV D
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 30/84 (35%), Positives = 39/84 (46%), Gaps = 6/84 (7%)

Query: 841 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVGEHKDKV 899
           R V+ +  H  +V S  FSP    LLTGS D  +   + + G L  +L     G H   V
Sbjct: 12  RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-----GGHTGPV 66

Query: 900 IQCRWHTQDLSFLSSSADRTVTLW 923
             CR+      F S+S D TV LW
Sbjct: 67  KFCRFSPDGHLFASASCDCTVRLW 90


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 80/273 (29%), Positives = 116/273 (42%), Gaps = 24/273 (8%)

Query: 662 FKRNKHHKGSIYCV-----AWSPCGQLLATGSNDKYVKVLPFNAETC-NATGPDLEFSMH 715
           F  NK H  ++ C      A++P G  +A G  D    V P   +   N        +MH
Sbjct: 93  FTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH 152

Query: 716 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALY---TW 772
              +   +F     S   IL ++G G C ++  D + GQ L +  GH   +L L    + 
Sbjct: 153 TNYLSACSFTN---SDMQILTASGDGTCALW--DVESGQLLQSFHGHGADVLCLDLAPSE 207

Query: 773 SGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSC 832
           +G    SG  DK    WD+R   CV+     F    S + SV   PSG   A+G +D++C
Sbjct: 208 TGNTFVSGGCDKKAMVWDMRSGQCVQA----FETHESDINSVRYYPSGDAFASGSDDATC 263

Query: 833 MLYDIRGGRMVQSYHPHSS--DVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 890
            LYD+R  R V  Y   S      SV FS     L  G  D  I V D+     K   + 
Sbjct: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV----LKGSRVS 319

Query: 891 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           ++  H+++V   R      +F S S D T+ +W
Sbjct: 320 ILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 63/234 (26%), Positives = 109/234 (46%), Gaps = 20/234 (8%)

Query: 657 QPVVRFKRN-KHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMH 715
           Q V++ +R  K H   + C+ W    + + + S D   KV+ +++ T N      E ++ 
Sbjct: 50  QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDG--KVIVWDSFTTNK-----EHAVT 102

Query: 716 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHA----LSGHTGHILAL-Y 770
                 +A    P SG AI        C++Y     + + + A    ++ HT ++ A  +
Sbjct: 103 MPCTWVMACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF 161

Query: 771 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPS--GRLLATGQE 828
           T S   I + S D T   WD+     ++    +FHG G+ V  + + PS  G    +G  
Sbjct: 162 TNSDMQILTASGDGTCALWDVESGQLLQ----SFHGHGADVLCLDLAPSETGNTFVSGGC 217

Query: 829 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 882
           D   M++D+R G+ VQ++  H SD+ SVR+ P      +GS D   ++ DL+ D
Sbjct: 218 DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD 271


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 80/273 (29%), Positives = 116/273 (42%), Gaps = 24/273 (8%)

Query: 662 FKRNKHHKGSIYCV-----AWSPCGQLLATGSNDKYVKVLPFNAETC-NATGPDLEFSMH 715
           F  NK H  ++ C      A++P G  +A G  D    V P   +   N        +MH
Sbjct: 135 FTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH 194

Query: 716 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALY---TW 772
              +   +F     S   IL ++G G C ++  D + GQ L +  GH   +L L    + 
Sbjct: 195 TNYLSACSFTN---SDMQILTASGDGTCALW--DVESGQLLQSFHGHGADVLCLDLAPSE 249

Query: 773 SGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSC 832
           +G    SG  DK    WD+R   CV+     F    S + SV   PSG   A+G +D++C
Sbjct: 250 TGNTFVSGGCDKKAMVWDMRSGQCVQA----FETHESDINSVRYYPSGDAFASGSDDATC 305

Query: 833 MLYDIRGGRMVQSYHPHSS--DVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 890
            LYD+R  R V  Y   S      SV FS     L  G  D  I V D+     K   + 
Sbjct: 306 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV----LKGSRVS 361

Query: 891 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           ++  H+++V   R      +F S S D T+ +W
Sbjct: 362 ILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 63/234 (26%), Positives = 109/234 (46%), Gaps = 20/234 (8%)

Query: 657 QPVVRFKRN-KHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMH 715
           Q V++ +R  K H   + C+ W    + + + S D   KV+ +++ T N      E ++ 
Sbjct: 92  QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDG--KVIVWDSFTTNK-----EHAVT 144

Query: 716 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHA----LSGHTGHILAL-Y 770
                 +A    P SG AI        C++Y     + + + A    ++ HT ++ A  +
Sbjct: 145 MPCTWVMACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF 203

Query: 771 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPS--GRLLATGQE 828
           T S   I + S D T   WD+     ++    +FHG G+ V  + + PS  G    +G  
Sbjct: 204 TNSDMQILTASGDGTCALWDVESGQLLQ----SFHGHGADVLCLDLAPSETGNTFVSGGC 259

Query: 829 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 882
           D   M++D+R G+ VQ++  H SD+ SVR+ P      +GS D   ++ DL+ D
Sbjct: 260 DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD 313


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 61/201 (30%), Positives = 96/201 (47%), Gaps = 15/201 (7%)

Query: 681 GQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGA 740
           G+LLATG +D  V +   N   C      +  + H   +  +  +  PE     LI AG+
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCI-----MSLTGHTSPVESVR-LNTPEE----LIVAGS 82

Query: 741 GDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRV 799
              +I   D +  + L  L GH  +I +L +   G  +ASGSQD  ++ WD+R   CV  
Sbjct: 83  QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCV-- 140

Query: 800 VGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFS 859
               + G   AV  +   P G+ LA+  +D +  L+D+  G+M+  +  H+  V  V F 
Sbjct: 141 --FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198

Query: 860 PGAHYLLTGSYDMKIKVTDLQ 880
           P  + L +GS D  I+  DL+
Sbjct: 199 PNEYLLASGSSDRTIRFWDLE 219



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 11/191 (5%)

Query: 735 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRV 793
           L++ G  DC +      +   + +L+GHT  + ++       +I +GSQ  ++R WDL  
Sbjct: 35  LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94

Query: 794 PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 853
              +R    T  G  + + S+   P G  +A+G +D++  L+DIR    V  Y  HS  V
Sbjct: 95  AKILR----TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150

Query: 854 RSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 912
           R +RFSP   +L + + D  +K+ DL  G +  + P      H   V    +H  +    
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP-----GHTGPVNVVEFHPNEYLLA 205

Query: 913 SSSADRTVTLW 923
           S S+DRT+  W
Sbjct: 206 SGSSDRTIRFW 216



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 4/105 (3%)

Query: 819 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
           SGRLLATG +D    L+ I     + S   H+S V SVR +     ++ GS    I+V D
Sbjct: 32  SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91

Query: 879 LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           L+    K L  ++   HK  +    +H       S S D  + LW
Sbjct: 92  LEA--AKILRTLM--GHKANICSLDFHPYGEFVASGSQDTNIKLW 132


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 62/262 (23%), Positives = 119/262 (45%), Gaps = 20/262 (7%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H+G +YC  + P G  LA+   D+ + +     +  N          H G + +L +   
Sbjct: 65  HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA----TLKGHSGAVMELHY--- 117

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALY--TWSGWMIASGSQDKT 785
             + G++L SA   D  +   D + G+ +  L GHT  + + Y       ++ +GS D T
Sbjct: 118 -NTDGSMLFSAST-DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175

Query: 786 VRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQS 845
           V+ WD+R  + ++    TF  T   +A    D S +++ +G  D+   ++D+R  ++  +
Sbjct: 176 VKLWDIRKKAAIQ----TFQNTYQVLAVTFNDTSDQII-SGGIDNDIKVWDLRQNKLTYT 230

Query: 846 YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMV----VGEHKDKVIQ 901
              H+  V  +  S    YLL+ + D  ++V D++    K+  + +    V   +  +++
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290

Query: 902 CRWHTQDLSFLSSSADRTVTLW 923
           C W        + SADR V +W
Sbjct: 291 CSWSPDGSKIAAGSADRFVYVW 312



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 54/226 (23%), Positives = 90/226 (39%), Gaps = 17/226 (7%)

Query: 661 RFKRNKHHKGSIY-CVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTI 719
           R KR K H   +  C       QL+ TGS+D  VK+     +    T           T 
Sbjct: 143 RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT--------FQNTY 194

Query: 720 RDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWS-GWMIA 778
           + LA      S   I   +G  D +I   D ++ +  + + GH   +  L   S G  + 
Sbjct: 195 QVLAVTFNDTSDQII---SGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLL 251

Query: 779 SGSQDKTVRFWDLRV----PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCML 834
           S + D TVR WD+R       CV++     H     +   +  P G  +A G  D    +
Sbjct: 252 SNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311

Query: 835 YDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 880
           +D    R++     H+  +  V F P    +++ S D ++ + ++Q
Sbjct: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 14/42 (33%), Positives = 23/42 (54%)

Query: 886 QLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYNG 927
           Q PIM++  H+ +V  C++H    +  S+  DR + LW   G
Sbjct: 56  QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG 97


>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
          Length = 607

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 126/546 (23%), Positives = 217/546 (39%), Gaps = 87/546 (15%)

Query: 419 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 475
           P + E +   D T    Q QE  + R+++Q+ L +  ++R    Q++++   NQ    D+
Sbjct: 64  PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122

Query: 476 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 518
           +  + E  +   +Q              KL +L      L +E  AL       +G    
Sbjct: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182

Query: 519 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 576
               N   VT +       + RL  +A N   S  R       +    + P   +   + 
Sbjct: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240

Query: 577 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVA-------FHPAGGLY 629
            VI     D                          E+T  VRA++         PAGGL 
Sbjct: 241 EVIVDETSDHT------------------------EETSPVRAISRAATKRLSQPAGGLL 276

Query: 630 AVGSNSKTLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 683
              +N    R V ++P   D +D  P + +  + P         H G +  V +SP  +L
Sbjct: 277 DSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRL 336

Query: 684 LATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDC 743
           LATG  D+ VK+     E C   G         G+   +  +E   +G  +L ++     
Sbjct: 337 LATGGMDRRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFAS 390

Query: 744 NIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGT 802
            I+T D  R +  H L+GH+G +L A +      I SGS D+T++ WDLR   C++ V  
Sbjct: 391 RIWTVDDYRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-- 446

Query: 803 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 862
                GS+   +    + + + +G  D     +DIR   +V+        + ++  +P  
Sbjct: 447 ---FAGSSCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPER 500

Query: 863 HYLLTGSYDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADR 918
             LL+ S D  +KV DL+ +  KQ    P    G    +V+     + D S++++ SA+ 
Sbjct: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEG 556

Query: 919 TVTLWT 924
           ++ +W+
Sbjct: 557 SLYIWS 562


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 63/213 (29%), Positives = 97/213 (45%), Gaps = 17/213 (7%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H G +Y  ++SP    L + S D  V++      TC      + +  H+  + D  F   
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL-----VGYKGHNYPVWDTQF--- 593

Query: 728 PESGGAILISAGAGD-CNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGWMIASGSQDKT 785
               G   +S G      ++ TD    Q L   +GH   +    +  +   +A+GS D+T
Sbjct: 594 -SPYGYYFVSGGHDRVARLWATD--HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650

Query: 786 VRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQS 845
           VR WD+   +CVR+    F G    + S+   P+GR LATG  D   +L+DI  G MV  
Sbjct: 651 VRLWDVLNGNCVRI----FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706

Query: 846 YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
              H+  V S+RFS     L +GS D  +++ D
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 59/228 (25%), Positives = 93/228 (40%), Gaps = 27/228 (11%)

Query: 710 LEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRG-------QGLHALSGH 762
           LE  M + T  +L  + G    G +  ++ + D N   +  + G       Q    L G+
Sbjct: 524 LERIMDEKTASELKILYG--HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581

Query: 763 TGHILALYTWS----GWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDP 818
            GH   ++       G+   SG  D+  R W       +R+    F G  + V      P
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI----FAGHLADVNCTRFHP 637

Query: 819 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
           +   +ATG  D +  L+D+  G  V+ +  H   + S+ FSP   +L TG+ D ++ + D
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697

Query: 879 LQGDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           +   L       +VGE   H D V   R+        S S D TV LW
Sbjct: 698 IGHGL-------MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 42/178 (23%), Positives = 65/178 (36%), Gaps = 37/178 (20%)

Query: 776 MIASGSQDKTVRFWDLRVPSCVRVVGTT----------------------------FHGT 807
           +IA G  D TVR W +  P  +R V                                +G 
Sbjct: 484 LIAGGFADSTVRVWSV-TPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGH 542

Query: 808 GSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLT 867
              V   +  P    L +  ED +  L+ ++    +  Y  H+  V   +FSP  +Y ++
Sbjct: 543 SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVS 602

Query: 868 GSYD--MKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           G +D   ++  TD         P+ +   H   V   R+H       + SADRTV LW
Sbjct: 603 GGHDRVARLWATD------HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/175 (25%), Positives = 65/175 (37%), Gaps = 66/175 (37%)

Query: 617 VRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVA 676
           V    FHP     A GS  +T+R+    DV++ +         VR      HKG I+ + 
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLW---DVLNGNC--------VRIFTG--HKGPIHSLT 676

Query: 677 WSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILI 736
           +SP G+ LATG+ D                                         G +L+
Sbjct: 677 FSPNGRFLATGATD-----------------------------------------GRVLL 695

Query: 737 SAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 790
                       D   G  +  L GHT  + +L ++  G ++ASGS D TVR WD
Sbjct: 696 -----------WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 83.6 bits (205), Expect = 8e-16
 Identities = 88/346 (25%), Positives = 153/346 (44%), Gaps = 40/346 (11%)

Query: 589 SLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVC-AYPDVI 647
           S S ++ +E  ++    +   ++  T+AV +V F P G   A  S  + + +  AY    
Sbjct: 16  SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75

Query: 648 DPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATG 707
           + + +               H   I  VAWS     L + S+DK +K+    +  C  T 
Sbjct: 76  EKTLYG--------------HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT- 120

Query: 708 PDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL 767
                  H   +    F   P S    LI +G+ D  +   + + G+ L  LS H+  + 
Sbjct: 121 ----LKGHSNYVFCCNF--NPPSN---LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVS 171

Query: 768 AL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATG 826
           A+ +  SG +I SGS D   R WD     C++   T        V+ V   P+G+ + T 
Sbjct: 172 AVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK---TLVDDDNPPVSFVKFSPNGKYILTA 228

Query: 827 QEDSSCMLYDIRGGRMVQSYHPHSSDVRSV--RFS-PGAHYLLTGSYDMKIKVTDLQGDL 883
             D++  L+D   GR +++Y  H ++   +   FS  G  ++++GS D  + + +LQ   
Sbjct: 229 TLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--- 285

Query: 884 TKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSA---DRTVTLWTYN 926
           TK++   + G H D VI    H  + + ++S+A   D+T+ LW  N
Sbjct: 286 TKEIVQKLQG-HTDVVISAACHPTE-NLIASAALENDKTIKLWMSN 329


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 84/318 (26%), Positives = 142/318 (44%), Gaps = 40/318 (12%)

Query: 614 TQAVRAVAFHPAGGLYAVGSNSKTLRVC-AYPDVIDPSAHETPKQPVVRFKRNKHHKGSI 672
           T+AV +V F P G   A  S  K +++  AY    +              K    HK  I
Sbjct: 45  TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--------------KTISGHKLGI 90

Query: 673 YCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGG 732
             VAWS    LL + S+DK +K+   ++  C  T        H   +    F   P+S  
Sbjct: 91  SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT-----LKGHSNYVFCCNF--NPQSN- 142

Query: 733 AILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDL 791
             LI +G+ D ++   D + G+ L  L  H+  + A+ +   G +I S S D   R WD 
Sbjct: 143 --LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200

Query: 792 RVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 851
               C++   T        V+ V   P+G+ +     D++  L+D   G+ +++Y  H +
Sbjct: 201 ASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257

Query: 852 DVRSV--RFS-PGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQD 908
           +   +   FS  G  ++++GS D  + + +LQ   TK++   + G H D VI    H  +
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ---TKEIVQKLQG-HTDVVISTACHPTE 313

Query: 909 LSFLSSSA---DRTVTLW 923
            + ++S+A   D+T+ LW
Sbjct: 314 -NIIASAALENDKTIKLW 330



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 19/229 (8%)

Query: 654 TPKQP--VVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLE 711
           TP +P   ++F    H K ++  V +SP G+ LA+ S DK +K+          T     
Sbjct: 29  TPVKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT----- 82

Query: 712 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 770
            S H   I D+A+     S   +L+SA + D  +   D   G+ L  L GH+ ++    +
Sbjct: 83  ISGHKLGISDVAW----SSDSNLLVSA-SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137

Query: 771 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 830
                +I SGS D++VR WD++   C++    T       V++V  +  G L+ +   D 
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLK----TLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 831 SCMLYDIRGGRMVQS-YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
            C ++D   G+ +++     +  V  V+FSP   Y+L  + D  +K+ D
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 42/169 (24%), Positives = 79/169 (46%), Gaps = 13/169 (7%)

Query: 763 TGHILAL--YTWSGW--MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDP 818
           +GH L +    WS    ++ S S DKT++ WD+    C++    T  G  + V     +P
Sbjct: 84  SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK----TLKGHSNYVFCCNFNP 139

Query: 819 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
              L+ +G  D S  ++D++ G+ +++   HS  V +V F+     +++ SYD   ++ D
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199

Query: 879 -LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
              G   K L    + +    V   ++       L+++ D T+ LW Y+
Sbjct: 200 TASGQCLKTL----IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 41/167 (24%), Positives = 81/167 (48%), Gaps = 11/167 (6%)

Query: 759 LSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVD 817
           L+GHT  + ++ ++ +G  +AS S DK ++ W        +    T  G    ++ VA  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK----TISGHKLGISDVAWS 96

Query: 818 PSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVT 877
               LL +  +D +  ++D+  G+ +++   HS+ V    F+P ++ +++GS+D  +++ 
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 878 DLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           D++ G   K LP      H D V    ++      +SSS D    +W
Sbjct: 157 DVKTGKCLKTLP-----AHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 84/318 (26%), Positives = 142/318 (44%), Gaps = 40/318 (12%)

Query: 614 TQAVRAVAFHPAGGLYAVGSNSKTLRVC-AYPDVIDPSAHETPKQPVVRFKRNKHHKGSI 672
           T+AV +V F P G   A  S  K +++  AY    +              K    HK  I
Sbjct: 45  TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--------------KTISGHKLGI 90

Query: 673 YCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGG 732
             VAWS    LL + S+DK +K+   ++  C  T        H   +    F   P+S  
Sbjct: 91  SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT-----LKGHSNYVFCCNF--NPQSN- 142

Query: 733 AILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDL 791
             LI +G+ D ++   D + G+ L  L  H+  + A+ +   G +I S S D   R WD 
Sbjct: 143 --LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200

Query: 792 RVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 851
               C++   T        V+ V   P+G+ +     D++  L+D   G+ +++Y  H +
Sbjct: 201 ASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257

Query: 852 DVRSV--RFS-PGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQD 908
           +   +   FS  G  ++++GS D  + + +LQ   TK++   + G H D VI    H  +
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ---TKEIVQKLQG-HTDVVISTACHPTE 313

Query: 909 LSFLSSSA---DRTVTLW 923
            + ++S+A   D+T+ LW
Sbjct: 314 -NIIASAALENDKTIKLW 330



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 19/229 (8%)

Query: 654 TPKQP--VVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLE 711
           TP +P   ++F    H K ++  V +SP G+ LA+ S DK +K+          T     
Sbjct: 29  TPVKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT----- 82

Query: 712 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 770
            S H   I D+A+     S   +L+SA + D  +   D   G+ L  L GH+ ++    +
Sbjct: 83  ISGHKLGISDVAW----SSDSNLLVSA-SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137

Query: 771 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 830
                +I SGS D++VR WD++   C++    T       V++V  +  G L+ +   D 
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLK----TLPAHSDPVSAVHFNRDGSLIVSSSYDG 193

Query: 831 SCMLYDIRGGRMVQS-YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
            C ++D   G+ +++     +  V  V+FSP   Y+L  + D  +K+ D
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 42/169 (24%), Positives = 79/169 (46%), Gaps = 13/169 (7%)

Query: 763 TGHILAL--YTWSGW--MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDP 818
           +GH L +    WS    ++ S S DKT++ WD+    C++    T  G  + V     +P
Sbjct: 84  SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK----TLKGHSNYVFCCNFNP 139

Query: 819 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 878
              L+ +G  D S  ++D++ G+ +++   HS  V +V F+     +++ SYD   ++ D
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199

Query: 879 -LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 926
              G   K L    + +    V   ++       L+++ D T+ LW Y+
Sbjct: 200 TASGQCLKTL----IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244



 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 41/167 (24%), Positives = 81/167 (48%), Gaps = 11/167 (6%)

Query: 759 LSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVD 817
           L+GHT  + ++ ++ +G  +AS S DK ++ W        +    T  G    ++ VA  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK----TISGHKLGISDVAWS 96

Query: 818 PSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVT 877
               LL +  +D +  ++D+  G+ +++   HS+ V    F+P ++ +++GS+D  +++ 
Sbjct: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156

Query: 878 DLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           D++ G   K LP      H D V    ++      +SSS D    +W
Sbjct: 157 DVKTGKCLKTLP-----AHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 63/219 (28%), Positives = 95/219 (43%), Gaps = 18/219 (8%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H   IY + W    +LL + S D   K++ +++ T N         MH   +R    M  
Sbjct: 54  HLAKIYAMHWGYDSRLLVSASQDG--KLIIWDSYTTN--------KMHAIPLRSSWVMTC 103

Query: 728 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 783
             +     ++ G  D  C+IY    + G  +    L GHTG++          I + S D
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGD 163

Query: 784 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 843
            T   WD+          TTF G    V S+++ P  R   +G  D+S  L+DIR G   
Sbjct: 164 TTCALWDIETAQQT----TTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219

Query: 844 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 882
           QS+  H SD+ +V F P  +   TGS D   ++ DL+ D
Sbjct: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRAD 258



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 52/210 (24%), Positives = 90/210 (42%), Gaps = 14/210 (6%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H G + C  +    Q++ T S D    +  ++ ET   T     F+ H G +  L+    
Sbjct: 142 HTGYLSCCRFLDDSQIV-TSSGDTTCAL--WDIETAQQT---TTFTGHSGDVMSLSLSPD 195

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTV 786
             +       +GA D +    D + G    + +GH   I A+  + +G+  A+GS D T 
Sbjct: 196 MRT-----FVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250

Query: 787 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 846
           R +DLR      ++  +       + SVA   SGRLL  G +D +C ++D   G      
Sbjct: 251 RLFDLRADQ--ELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVL 308

Query: 847 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKV 876
             H + V  +  +     + TGS+D  +++
Sbjct: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLRI 338



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 9/124 (7%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H   I  V++ P G   ATGS+D   ++    A+       +L    HD  I  +  +  
Sbjct: 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQ------ELLLYSHDNIICGITSVAF 278

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 786
            +SG  +L      +CN++  D  +G     L+GH   +  L  T  G  +A+GS D  +
Sbjct: 279 SKSGRLLLAGYDDFNCNVW--DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336

Query: 787 RFWD 790
           R W+
Sbjct: 337 RIWN 340



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 37/154 (24%), Positives = 69/154 (44%), Gaps = 4/154 (2%)

Query: 735 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRV 793
           L+ + + D  +   D      +HA+   +  ++   Y  SG  +A G  D     ++L+ 
Sbjct: 69  LLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT 128

Query: 794 -PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSD 852
               VRV       TG       +D S  + ++G  D++C L+DI   +   ++  HS D
Sbjct: 129 REGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG--DTTCALWDIETAQQTTTFTGHSGD 186

Query: 853 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQ 886
           V S+  SP     ++G+ D   K+ D++  + +Q
Sbjct: 187 VMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQ 220



 Score = 34.3 bits (77), Expect = 0.55
 Identities = 26/106 (24%), Positives = 48/106 (45%), Gaps = 7/106 (6%)

Query: 821 RLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 880
           RLL +  +D   +++D      + +    SS V +  ++P  +Y+  G  D    + +L+
Sbjct: 68  RLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127

Query: 881 GDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
              T++  + V  E   H   +  CR+   D   ++SS D T  LW
Sbjct: 128 ---TREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTCALW 169


>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
          Length = 588

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 122/539 (22%), Positives = 212/539 (39%), Gaps = 92/539 (17%)

Query: 419 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 475
           P + E +   D T    Q QE  + R+++Q+ L +  ++R    Q++++   NQ    D+
Sbjct: 64  PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122

Query: 476 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 518
           +  + E  +   +Q              KL +L      L +E  AL       +G    
Sbjct: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182

Query: 519 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 576
               N   VT +       + RL  +A N   S  R       +    + P   +   + 
Sbjct: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240

Query: 577 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSK 636
            VI     D                          E+T  VRA+            S + 
Sbjct: 241 EVIVDETSDHT------------------------EETSPVRAI------------SRAA 264

Query: 637 TLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSND 690
           T R V ++P   D +D  P + +  + P         H G +  V +SP  +LLATG  D
Sbjct: 265 TRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMD 324

Query: 691 KYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDC 750
           + VK+     E C   G         G+   +  +E   +G  +L ++      I+T D 
Sbjct: 325 RRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDD 378

Query: 751 QRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGS 809
            R +  H L+GH+G +L A +      I SGS D+T++ WDLR   C++ V       GS
Sbjct: 379 YRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-----FAGS 431

Query: 810 AVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGS 869
           +   +    + + + +G  D     +DIR   +V+        + ++  +P    LL+ S
Sbjct: 432 SCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCS 488

Query: 870 YDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADRTVTLWT 924
            D  +KV DL+ +  KQ    P    G    +V+     + D S++++ SA+ ++ +W+
Sbjct: 489 RDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEGSLYIWS 543


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score = 80.5 bits (197), Expect = 7e-15
 Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 18/219 (8%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H   IY + W    +LL + S D   K++ +++ T N         +H   +R    M  
Sbjct: 54  HLAKIYAMHWGTDSRLLVSASQDG--KLIIWDSYTTN--------KVHAIPLRSSWVMTC 103

Query: 728 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 783
             +     ++ G  D  C+IY    + G  +    L+GHTG++          I + S D
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163

Query: 784 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 843
            T   WD+          TTF G    V S+++ P  RL  +G  D+S  L+D+R G   
Sbjct: 164 TTCALWDIETGQQT----TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219

Query: 844 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 882
           Q++  H SD+ ++ F P  +   TGS D   ++ DL+ D
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD 258



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 66/253 (26%), Positives = 112/253 (44%), Gaps = 22/253 (8%)

Query: 676 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 735
           A++P G  +A G  D    +        N      E + H G +    F++  +    I+
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVR-VSRELAGHTGYLSCCRFLDDNQ----IV 158

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGW-MIASGSQDKTVRFWDLRVP 794
            S+G   C ++  D + GQ     +GHTG +++L       +  SG+ D + + WD+R  
Sbjct: 159 TSSGDTTCALW--DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216

Query: 795 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS--SD 852
            C +    TF G  S + ++   P+G   ATG +D++C L+D+R  + + +Y   +    
Sbjct: 217 MCRQ----TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272

Query: 853 VRSVRFSPGAHYLLTGSYDMKIKVTD-LQGDLTKQLPIMVVGEHKDKVIQCRWHTQD-LS 910
           + SV FS     LL G  D    V D L+ D        V+  H D  + C   T D ++
Sbjct: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG-----VLAGH-DNRVSCLGVTDDGMA 326

Query: 911 FLSSSADRTVTLW 923
             + S D  + +W
Sbjct: 327 VATGSWDSFLKIW 339



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 17/177 (9%)

Query: 712 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 770
           ++MH GT  D   +      G ++I       + YTT+      +HA+   +  ++   Y
Sbjct: 59  YAMHWGT--DSRLLVSASQDGKLII------WDSYTTN-----KVHAIPLRSSWVMTCAY 105

Query: 771 TWSGWMIASGSQDKTVRFWDLRV-PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQED 829
             SG  +A G  D     ++L+     VRV       TG       +D +  + ++G  D
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--D 163

Query: 830 SSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQ 886
           ++C L+DI  G+   ++  H+ DV S+  +P     ++G+ D   K+ D++  + +Q
Sbjct: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 29/124 (23%), Positives = 54/124 (43%), Gaps = 7/124 (5%)

Query: 803 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 862
           T  G  + + ++      RLL +  +D   +++D      V +    SS V +  ++P  
Sbjct: 50  TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109

Query: 863 HYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRT 919
           +Y+  G  D    + +L+   T++  + V  E   H   +  CR+   D   ++SS D T
Sbjct: 110 NYVACGGLDNICSIYNLK---TREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTT 165

Query: 920 VTLW 923
             LW
Sbjct: 166 CALW 169


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 18/219 (8%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H   IY + W    +LL + S D   K++ +++ T N         +H   +R    M  
Sbjct: 54  HLAKIYAMHWGTDSRLLVSASQDG--KLIIWDSYTTN--------KVHAIPLRSSWVMTC 103

Query: 728 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 783
             +     ++ G  D  C+IY+   + G  +    L GHTG++          I + S D
Sbjct: 104 AYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD 163

Query: 784 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 843
            T   WD+      + VG  F G    V S+++ P GR   +G  D+S  L+D+R     
Sbjct: 164 TTCALWDIETGQ--QTVG--FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219

Query: 844 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 882
           Q++  H SD+ +V F P  +   TGS D   ++ DL+ D
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD 258



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 14/210 (6%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H G + C  +    Q++ T S D    +  ++ ET   T   + F+ H G +  L+    
Sbjct: 142 HTGYLSCCRFLDDNQII-TSSGDTTCAL--WDIETGQQT---VGFAGHSGDVMSLSL--A 193

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTV 786
           P+  G   +S GA D +I   D +         GH   I A+  + +G+   +GS D T 
Sbjct: 194 PD--GRTFVS-GACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATC 250

Query: 787 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 846
           R +DLR      ++  +       + SVA   SGRLL  G +D +C ++D   G      
Sbjct: 251 RLFDLRADQ--ELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVL 308

Query: 847 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKV 876
             H + V  +  +     + TGS+D  +K+
Sbjct: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 51/214 (23%), Positives = 92/214 (42%), Gaps = 21/214 (9%)

Query: 712 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 770
           ++MH GT  D   +      G ++I       + YTT+      +HA+   +  ++   Y
Sbjct: 59  YAMHWGT--DSRLLVSASQDGKLII------WDSYTTN-----KVHAIPLRSSWVMTCAY 105

Query: 771 TWSGWMIASGSQDKTVRFWDLRV-PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQED 829
             SG  +A G  D     + L+     VRV       TG       +D +  + ++G  D
Sbjct: 106 APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG--D 163

Query: 830 SSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPI 889
           ++C L+DI  G+    +  HS DV S+  +P     ++G+ D  IK+ D++  + +Q  I
Sbjct: 164 TTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFI 223

Query: 890 MVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
                H+  +    +     +F + S D T  L+
Sbjct: 224 ----GHESDINAVAFFPNGYAFTTGSDDATCRLF 253



 Score = 33.9 bits (76), Expect = 0.72
 Identities = 28/124 (22%), Positives = 53/124 (42%), Gaps = 7/124 (5%)

Query: 803 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 862
           T  G  + + ++      RLL +  +D   +++D      V +    SS V +  ++P  
Sbjct: 50  TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109

Query: 863 HYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRT 919
           +++  G  D    +  L+   T++  + V  E   H   +  CR+   D   ++SS D T
Sbjct: 110 NFVACGGLDNICSIYSLK---TREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTT 165

Query: 920 VTLW 923
             LW
Sbjct: 166 CALW 169


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 67/270 (24%), Positives = 123/270 (45%), Gaps = 23/270 (8%)

Query: 660 VRFKRNKHHKGSIYCVAWSPC----GQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMH 715
           + FK+ + H  +I+ VAW        + + TGS D  VKV  +  E       DL++S+ 
Sbjct: 7   ILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERL-----DLQWSLE 61

Query: 716 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHAL-SGHTGHILALYTWSG 774
                 L  +    S    + ++ + D +I   D + G+ + ++ +G        ++   
Sbjct: 62  G---HQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118

Query: 775 WMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCML 834
             +A+G+    V  + +        + T     G  + S+A  P G+ LA+G  D    +
Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTR----GKFILSIAYSPDGKYLASGAIDGIINI 174

Query: 835 YDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVG 893
           +DI  G+++ +   H+  +RS+ FSP +  L+T S D  IK+ D+Q  +L   L      
Sbjct: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-----S 229

Query: 894 EHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
            H   V+   +   D  F+SSS+D++V +W
Sbjct: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 59/219 (26%), Positives = 94/219 (42%), Gaps = 18/219 (8%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H   IY + W+   +LL + S D   K++ +++ T N         +H   +R    M  
Sbjct: 54  HLAKIYAMHWATDSKLLVSASQDG--KLIVWDSYTTN--------KVHAIPLRSSWVMTC 103

Query: 728 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 783
             +     ++ G  D  C+IY    + G  +    LS HTG++          I + S D
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD 163

Query: 784 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 843
            T   WD+          T F G      S+AV P   L  +G  D+S  L+D+R G   
Sbjct: 164 TTCALWDIETGQ----QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCR 219

Query: 844 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 882
           Q++  H SD+ ++ F P    + TGS D   ++ DL+ D
Sbjct: 220 QTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRAD 258



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 3/143 (2%)

Query: 735 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTVRFWDLRV 793
           L  +GA D +    D + G      +GH   I A+  + +G  I +GS D + R +DLR 
Sbjct: 198 LFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA 257

Query: 794 PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 853
                ++  +       + SVA   SGRLL  G +D +C ++D      V     H + V
Sbjct: 258 DQ--ELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 315

Query: 854 RSVRFSPGAHYLLTGSYDMKIKV 876
             +  +     + TGS+D  +K+
Sbjct: 316 SCLGVTADGMAVATGSWDSFLKI 338



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 32/124 (25%), Positives = 55/124 (44%), Gaps = 9/124 (7%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H+  I  + + P G+ + TGS+D   ++    A+       +L    H+  I  +  +  
Sbjct: 225 HESDINAICFFPNGEAICTGSDDASCRLFDLRADQ------ELICFSHESIICGITSVAF 278

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 786
             SG   L+ AG  D N    D  + + +  LSGH   +  L  T  G  +A+GS D  +
Sbjct: 279 SLSGR--LLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFL 336

Query: 787 RFWD 790
           + W+
Sbjct: 337 KIWN 340



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 34/154 (22%), Positives = 68/154 (44%), Gaps = 4/154 (2%)

Query: 735 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRV 793
           L+ + + D  +   D      +HA+   +  ++   Y  SG  +A G  D     ++L+ 
Sbjct: 69  LLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKS 128

Query: 794 -PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSD 852
               V+V       TG       +D +  + ++G  D++C L+DI  G+    +  H+ D
Sbjct: 129 REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG--DTTCALWDIETGQQKTVFVGHTGD 186

Query: 853 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQ 886
             S+  SP  +  ++G+ D   K+ D++    +Q
Sbjct: 187 CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQ 220



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 22/103 (21%), Positives = 44/103 (42%), Gaps = 1/103 (0%)

Query: 821 RLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 880
           +LL +  +D   +++D      V +    SS V +  ++P  +++  G  D    + +L+
Sbjct: 68  KLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLK 127

Query: 881 GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
                      +  H   +  CR+   D + ++SS D T  LW
Sbjct: 128 SREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSGDTTCALW 169


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 33/266 (12%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDG-TIRDLAFME 726
           H GS+ C+ +    +++ TGS+D  V+V   N      TG  L   +H    +  L F  
Sbjct: 279 HTGSVLCLQYDE--RVIVTGSSDSTVRVWDVN------TGEVLNTLIHHNEAVLHLRFSN 330

Query: 727 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYT--WSGWMIASGSQDK 784
           G       L+   + D +I   D      +       GH  A+    +    I S S D+
Sbjct: 331 G-------LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 383

Query: 785 TVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 844
           T++ W       VR    T +G    +A +      RL+ +G  D++  L+DI  G  ++
Sbjct: 384 TIKVWSTSTCEFVR----TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLR 437

Query: 845 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLP-----IMVVGEHKDKV 899
               H   VR +RF      +++G+YD KIKV DLQ  L  + P     +  + EH  +V
Sbjct: 438 VLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 495

Query: 900 IQCRWHTQDLSFLSSSADRTVTLWTY 925
            + ++   +   +SSS D T+ +W +
Sbjct: 496 FRLQF--DEFQIISSSHDDTILIWDF 519



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 41/148 (27%), Positives = 74/148 (50%), Gaps = 11/148 (7%)

Query: 777 IASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 836
           I SG +D +++ WD     C++V+      TG   + + +    R++ TG  DS+  ++D
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWD 306

Query: 837 IRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHK 896
           +  G ++ +   H+  V  +RFS G   ++T S D  I V D+       L  ++VG H+
Sbjct: 307 VNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVG-HR 363

Query: 897 DKVIQCRWHTQDLSFLSSSADRTVTLWT 924
             V    +   D   +S+S DRT+ +W+
Sbjct: 364 AAVNVVDF--DDKYIVSASGDRTIKVWS 389



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 18/191 (9%)

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPS 795
           I +G  D +I   D    + L  L+GHTG +L L  +   +I +GS D TVR WD+    
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYDERVIVTGSSDSTVRVWDVNTG- 310

Query: 796 CVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV---QSYHPHSSD 852
              V+ T  H      A + +  S  L+ T  +D S  ++D+     +   +    H + 
Sbjct: 311 --EVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 365

Query: 853 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 912
           V  V F     Y+++ S D  IKV       T +  +  +  HK + I C  + +D   +
Sbjct: 366 VNVVDFDD--KYIVSASGDRTIKVWSTS---TCEF-VRTLNGHK-RGIACLQY-RDRLVV 417

Query: 913 SSSADRTVTLW 923
           S S+D T+ LW
Sbjct: 418 SGSSDNTIRLW 428


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 33/266 (12%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDG-TIRDLAFME 726
           H GS+ C+ +    +++ TGS+D  V+V   N      TG  L   +H    +  L F  
Sbjct: 245 HTGSVLCLQYDE--RVIVTGSSDSTVRVWDVN------TGEVLNTLIHHNEAVLHLRFSN 296

Query: 727 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYT--WSGWMIASGSQDK 784
           G       L+   + D +I   D      +       GH  A+    +    I S S D+
Sbjct: 297 G-------LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 349

Query: 785 TVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 844
           T++ W       VR    T +G    +A +      RL+ +G  D++  L+DI  G  ++
Sbjct: 350 TIKVWSTSTCEFVR----TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLR 403

Query: 845 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLP-----IMVVGEHKDKV 899
               H   VR +RF      +++G+YD KIKV DLQ  L  + P     +  + EH  +V
Sbjct: 404 VLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 461

Query: 900 IQCRWHTQDLSFLSSSADRTVTLWTY 925
            + ++   +   +SSS D T+ +W +
Sbjct: 462 FRLQF--DEFQIISSSHDDTILIWDF 485



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 41/148 (27%), Positives = 74/148 (50%), Gaps = 11/148 (7%)

Query: 777 IASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 836
           I SG +D +++ WD     C++V+      TG   + + +    R++ TG  DS+  ++D
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWD 272

Query: 837 IRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHK 896
           +  G ++ +   H+  V  +RFS G   ++T S D  I V D+       L  ++VG H+
Sbjct: 273 VNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVG-HR 329

Query: 897 DKVIQCRWHTQDLSFLSSSADRTVTLWT 924
             V    +   D   +S+S DRT+ +W+
Sbjct: 330 AAVNVVDF--DDKYIVSASGDRTIKVWS 355



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 18/191 (9%)

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPS 795
           I +G  D +I   D    + L  L+GHTG +L L  +   +I +GS D TVR WD+    
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYDERVIVTGSSDSTVRVWDVNTG- 276

Query: 796 CVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV---QSYHPHSSD 852
              V+ T  H      A + +  S  L+ T  +D S  ++D+     +   +    H + 
Sbjct: 277 --EVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331

Query: 853 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 912
           V  V F     Y+++ S D  IKV       T +  +  +  HK + I C  + +D   +
Sbjct: 332 VNVVDFDD--KYIVSASGDRTIKVWSTS---TCEF-VRTLNGHK-RGIACLQY-RDRLVV 383

Query: 913 SSSADRTVTLW 923
           S S+D T+ LW
Sbjct: 384 SGSSDNTIRLW 394


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 33/266 (12%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDG-TIRDLAFME 726
           H GS+ C+ +    +++ TGS+D  V+V   N      TG  L   +H    +  L F  
Sbjct: 266 HTGSVLCLQYDE--RVIVTGSSDSTVRVWDVN------TGEVLNTLIHHNEAVLHLRFSN 317

Query: 727 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYT--WSGWMIASGSQDK 784
           G       L+   + D +I   D      +       GH  A+    +    I S S D+
Sbjct: 318 G-------LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 370

Query: 785 TVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 844
           T++ W       VR    T +G    +A +      RL+ +G  D++  L+DI  G  ++
Sbjct: 371 TIKVWSTSTCEFVR----TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLR 424

Query: 845 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLP-----IMVVGEHKDKV 899
               H   VR +RF      +++G+YD KIKV DLQ  L  + P     +  + EH  +V
Sbjct: 425 VLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 482

Query: 900 IQCRWHTQDLSFLSSSADRTVTLWTY 925
            + ++   +   +SSS D T+ +W +
Sbjct: 483 FRLQF--DEFQIISSSHDDTILIWDF 506



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 41/148 (27%), Positives = 74/148 (50%), Gaps = 11/148 (7%)

Query: 777 IASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 836
           I SG +D +++ WD     C++V+      TG   + + +    R++ TG  DS+  ++D
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWD 293

Query: 837 IRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHK 896
           +  G ++ +   H+  V  +RFS G   ++T S D  I V D+       L  ++VG H+
Sbjct: 294 VNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVG-HR 350

Query: 897 DKVIQCRWHTQDLSFLSSSADRTVTLWT 924
             V    +   D   +S+S DRT+ +W+
Sbjct: 351 AAVNVVDF--DDKYIVSASGDRTIKVWS 376



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 18/191 (9%)

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPS 795
           I +G  D +I   D    + L  L+GHTG +L L  +   +I +GS D TVR WD+    
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYDERVIVTGSSDSTVRVWDVNTG- 297

Query: 796 CVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV---QSYHPHSSD 852
              V+ T  H      A + +  S  L+ T  +D S  ++D+     +   +    H + 
Sbjct: 298 --EVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352

Query: 853 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 912
           V  V F     Y+++ S D  IKV       T +  +  +  HK + I C  + +D   +
Sbjct: 353 VNVVDFDD--KYIVSASGDRTIKVWSTS---TCEF-VRTLNGHK-RGIACLQY-RDRLVV 404

Query: 913 SSSADRTVTLW 923
           S S+D T+ LW
Sbjct: 405 SGSSDNTIRLW 415


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 79/325 (24%), Positives = 133/325 (40%), Gaps = 46/325 (14%)

Query: 617 VRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRN-KHHKGSIYCV 675
           V  V FHP   +    S   T++V  Y         ET       F+R  K H  S+  +
Sbjct: 111 VTRVIFHPVFSVMVSASEDATIKVWDY---------ETGD-----FERTLKGHTDSVQDI 156

Query: 676 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 735
           ++   G+LLA+ S D  +K+  F    C  T        HD  +  +A M      G  +
Sbjct: 157 SFDHSGKLLASCSADMTIKLWDFQGFECIRT-----MHGHDHNVSSVAIM----PNGDHI 207

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGWMIASGSQDKTVRFW----- 789
           +SA + D  I   + Q G  +   +GH   + +      G +IAS S D+TVR W     
Sbjct: 208 VSA-SRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266

Query: 790 ----DLR----VPSCVRVVGTTFHGTGSAVASVAVDPSGR---LLATGQEDSSCMLYDIR 838
               +LR    V  C+     + + + S         SG+    L +G  D +  ++D+ 
Sbjct: 267 ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVS 326

Query: 839 GGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDK 898
            G  + +   H + VR V F  G  ++L+ + D  ++V D +     +  +  +  H+  
Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK----NKRCMKTLNAHEHF 382

Query: 899 VIQCRWHTQDLSFLSSSADRTVTLW 923
           V    +H      ++ S D+TV +W
Sbjct: 383 VTSLDFHKTAPYVVTGSVDQTVKVW 407



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 45/168 (26%), Positives = 78/168 (46%), Gaps = 9/168 (5%)

Query: 757 HALSGHTGHILALYTWSGWMI-ASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVA 815
           +ALSGH   +  +     + +  S S+D T++ WD       R    T  G   +V  ++
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFER----TLKGHTDSVQDIS 157

Query: 816 VDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIK 875
            D SG+LLA+   D +  L+D +G   +++ H H  +V SV   P   ++++ S D  IK
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217

Query: 876 VTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
           + ++Q        +     H++ V   R +       S S D+TV +W
Sbjct: 218 MWEVQTGYC----VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 62/279 (22%), Positives = 116/279 (41%), Gaps = 39/279 (13%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H+  +  V + P   ++ + S D  +KV  +       T        H  +++D++F   
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT-----LKGHTDSVQDISF--- 158

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTV 786
            +  G +L S  A D  I   D Q  + +  + GH  ++ ++    +G  I S S+DKT+
Sbjct: 159 -DHSGKLLASCSA-DMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216

Query: 787 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 846
           + W+++   CV+    TF G    V  V  +  G L+A+   D +  ++ +         
Sbjct: 217 KMWEVQTGYCVK----TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272

Query: 847 HPHSSDVRSVRFSPGAHY--------------------LLTGSYDMKIKVTDLQGDLTKQ 886
             H   V  + ++P + Y                    LL+GS D  IK+ D+   +   
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC-- 330

Query: 887 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTY 925
             +M +  H + V    +H+     LS + D+T+ +W Y
Sbjct: 331 --LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 62/289 (21%), Positives = 112/289 (38%), Gaps = 58/289 (20%)

Query: 614 TQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIY 673
           T +V+ ++F  +G L A  S   T+++  +             Q     +    H  ++ 
Sbjct: 150 TDSVQDISFDHSGKLLASCSADMTIKLWDF-------------QGFECIRTMHGHDHNVS 196

Query: 674 CVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGA 733
            VA  P G  + + S DK +K+       C  T     F+ H   +R    M  P   G 
Sbjct: 197 SVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKT-----FTGHREWVR----MVRPNQDGT 247

Query: 734 ILISAGAGDCN----IYTTDCQRGQGLHALSGHTGHILALYTWS---------------- 773
           ++ S           + T +C+     H       H++   +W+                
Sbjct: 248 LIASCSNDQTVRVWVVATKECKAELREHE------HVVECISWAPESSYSSISEATGSET 301

Query: 774 ------GWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQ 827
                 G  + SGS+DKT++ WD+    C+     T  G  + V  V     G+ + +  
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM----TLVGHDNWVRGVLFHSGGKFILSCA 357

Query: 828 EDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKV 876
           +D +  ++D +  R +++ + H   V S+ F   A Y++TGS D  +KV
Sbjct: 358 DDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 55/237 (23%), Positives = 93/237 (39%), Gaps = 44/237 (18%)

Query: 577 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSK 636
           SV   P GD   S SR K  +  + +  +         + VR V  +  G L A  SN +
Sbjct: 197 SVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQ 256

Query: 637 TLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSP----------------- 679
           T+RV               K+     + ++H    + C++W+P                 
Sbjct: 257 TVRVWVV----------ATKECKAELREHEH---VVECISWAPESSYSSISEATGSETKK 303

Query: 680 ---CGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILI 736
               G  L +GS DK +K+   +   C  T        HD  +R + F     SGG  ++
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMT-----LVGHDNWVRGVLF----HSGGKFIL 354

Query: 737 SAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLR 792
           S  A D  +   D +  + +  L+ H   + +L +  +   + +GS D+TV+ W+ R
Sbjct: 355 SC-ADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 26/80 (32%), Positives = 34/80 (42%), Gaps = 6/80 (7%)

Query: 849 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQ 907
           H S V  V F P    +++ S D  IKV D + GD  + L       H D V    +   
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLK-----GHTDSVQDISFDHS 161

Query: 908 DLSFLSSSADRTVTLWTYNG 927
                S SAD T+ LW + G
Sbjct: 162 GKLLASCSADMTIKLWDFQG 181


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 17/215 (7%)

Query: 713 SMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI--LALY 770
           S H G +R +A   G +         G+ D  I   D   G+   +L+GH   +  + + 
Sbjct: 201 SGHLGWVRCIAVEPGNQ-----WFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255

Query: 771 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 830
           T S ++ + G +DK V+ WDL     +R     +HG  SAV  + + P+  +L T   DS
Sbjct: 256 TRSPYLFSCG-EDKQVKCWDLEYNKVIR----HYHGHLSAVYGLDLHPTIDVLVTCSRDS 310

Query: 831 SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 890
           +  ++D+R    V +   H++ V +VR       ++TGS+D  I++ DL    T+    +
Sbjct: 311 TARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTR----V 366

Query: 891 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTY 925
            +  HK  V     H +  +F S S D  +  W +
Sbjct: 367 TLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKF 400



 Score = 37.4 bits (85), Expect = 0.065
 Identities = 45/211 (21%), Positives = 75/211 (35%), Gaps = 40/211 (18%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAET----------------CNATGPDLE 711
           H  ++Y +   P   +L T S D   ++     +                 C A  P + 
Sbjct: 287 HLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII 346

Query: 712 FSMHDGTIRDLAFMEGP---------ESGGAILI-------SAGAGDCNIYTTDCQRGQG 755
              HD TIR    + G          +S  A+++       ++G+ D NI       G  
Sbjct: 347 TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSF 405

Query: 756 LHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVA 815
           +  LSGH   I  L   S  ++ SG+ + T+  WD R        G  F    +AV   +
Sbjct: 406 IQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWR-------TGYNFQRVHAAVQPGS 458

Query: 816 VDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 846
           +D    + A   + S   L      + ++ Y
Sbjct: 459 LDSESGIFACAFDQSESRLLTAEADKTIKVY 489


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 13/165 (7%)

Query: 764 GHILALYTWS----GWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPS 819
           GH + +Y  +    G +  +G  D   R WDLR   C+  +     G    +  +   P+
Sbjct: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL----EGHLKEIYGINFSPN 418

Query: 820 GRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSP-GAHYLLTGSYDMKIKVTD 878
           G  +ATG  D++C ++D+R  R V +   H + V  V+F P   ++LLTG+YD   K+  
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478

Query: 879 LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
             G      P+  +  H+ KV+     +      + S DRT  LW
Sbjct: 479 HPG----WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 49/195 (25%), Positives = 89/195 (45%), Gaps = 12/195 (6%)

Query: 736 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW--SGWMIASGSQDKTVRFWDLRV 793
           +++ A D ++        + +  + GHT  + A   W  SG  + +   D++ R WDL  
Sbjct: 296 LASCAADGSVKLWSLDSDEPVADIEGHTVRV-ARVMWHPSGRFLGTTCYDRSWRLWDLEA 354

Query: 794 PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 853
                ++    H  G  V  +A    G L  TG  D+   ++D+R GR +     H  ++
Sbjct: 355 QE--EILHQEGHSMG--VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410

Query: 854 RSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLS 913
             + FSP  +++ TGS D   KV DL+    ++  +  +  H++ V   ++     +FL 
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLR----QRRCVYTIPAHQNLVTGVKFEPIHGNFLL 466

Query: 914 SSA-DRTVTLWTYNG 927
           + A D T  +WT+ G
Sbjct: 467 TGAYDNTAKIWTHPG 481



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 37/123 (30%), Positives = 52/123 (42%), Gaps = 10/123 (8%)

Query: 668 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 727
           H   IY + +SP G  +ATGS D   KV       C  T P      H   +  + F   
Sbjct: 406 HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP-----AHQNLVTGVKF--E 458

Query: 728 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 786
           P  G  +L  A      I+T        L  L+GH G ++ L  +  G +IA+ S D+T 
Sbjct: 459 PIHGNFLLTGAYDNTAKIWTH--PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTF 516

Query: 787 RFW 789
           + W
Sbjct: 517 KLW 519



 Score = 35.0 bits (79), Expect = 0.32
 Identities = 29/111 (26%), Positives = 47/111 (42%), Gaps = 8/111 (7%)

Query: 776 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGT--GSAV----ASVAVDPSGRLLATGQED 829
           M+A+       + W   VP C  +     H T  G+ V    ++V++DP    LA+   D
Sbjct: 245 MLATACWSGLCKLWS--VPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAAD 302

Query: 830 SSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 880
            S  L+ +     V     H+  V  V + P   +L T  YD   ++ DL+
Sbjct: 303 GSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353



 Score = 34.7 bits (78), Expect = 0.42
 Identities = 24/114 (21%), Positives = 49/114 (42%), Gaps = 12/114 (10%)

Query: 818 PSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHY--------LLTGS 869
           P+ ++LAT      C L+ +    ++ +   H+++V ++ F P +          L + +
Sbjct: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300

Query: 870 YDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 923
            D  +K+  L  D     P+  +  H  +V +  WH       ++  DR+  LW
Sbjct: 301 ADGSVKLWSLDSD----EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,440,726
Number of Sequences: 37866
Number of extensions: 1800233
Number of successful extensions: 9002
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 180
Number of HSP's successfully gapped in prelim test: 197
Number of HSP's that attempted gapping in prelim test: 6490
Number of HSP's gapped (non-prelim): 1583
length of query: 927
length of database: 18,247,518
effective HSP length: 112
effective length of query: 815
effective length of database: 14,006,526
effective search space: 11415318690
effective search space used: 11415318690
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press