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Search of human proteins with 216548347
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
(920 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens] 1873 0.0
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens] 1867 0.0
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens] 1866 0.0
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 110 5e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 110 5e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 110 5e-24
gi|26665869 WD repeat domain 51B [Homo sapiens] 101 3e-21
gi|32189425 WD repeat domain 69 [Homo sapiens] 100 5e-21
gi|113865883 WD repeat domain 38 [Homo sapiens] 96 2e-19
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 95 3e-19
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 95 3e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 92 3e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 92 3e-18
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 86 2e-16
gi|21071067 TBP-associated factor 5 [Homo sapiens] 84 8e-16
gi|23199987 WD repeat domain 5B [Homo sapiens] 84 8e-16
gi|16554629 WD repeat domain 5 [Homo sapiens] 83 1e-15
gi|16554627 WD repeat domain 5 [Homo sapiens] 83 1e-15
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 83 1e-15
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 81 5e-15
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 80 7e-15
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 78 3e-14
gi|13376840 WD repeat domain 61 [Homo sapiens] 77 7e-14
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 76 1e-13
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 74 6e-13
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 74 6e-13
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 74 6e-13
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 72 2e-12
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 70 1e-11
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 69 2e-11
>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
Length = 920
Score = 1873 bits (4852), Expect = 0.0
Identities = 920/920 (100%), Positives = 920/920 (100%)
Query: 1 MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
Sbjct: 1 MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
Query: 61 WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC 120
WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC
Sbjct: 61 WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC 120
Query: 121 LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR 180
LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR
Sbjct: 121 LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR 180
Query: 181 KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL 240
KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL
Sbjct: 181 KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL 240
Query: 241 DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR 300
DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR
Sbjct: 241 DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR 300
Query: 301 RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL 360
RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL
Sbjct: 301 RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL 360
Query: 361 MLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNEL 420
MLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNEL
Sbjct: 361 MLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNEL 420
Query: 421 RDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRS 480
RDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRS
Sbjct: 421 RDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRS 480
Query: 481 IQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIH 540
IQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIH
Sbjct: 481 IQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIH 540
Query: 541 TSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVC 600
TSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVC
Sbjct: 541 TSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVC 600
Query: 601 INILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKH 660
INILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKH
Sbjct: 601 INILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKH 660
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG
Sbjct: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVR 780
PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVR
Sbjct: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVR 780
Query: 781 FWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH 840
FWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH
Sbjct: 781 FWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH 840
Query: 841 PHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQ 900
PHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQ
Sbjct: 841 PHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQ 900
Query: 901 DLSFLSSSADRTVTLWTYNG 920
DLSFLSSSADRTVTLWTYNG
Sbjct: 901 DLSFLSSSADRTVTLWTYNG 920
>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
Length = 919
Score = 1867 bits (4836), Expect = 0.0
Identities = 919/920 (99%), Positives = 919/920 (99%), Gaps = 1/920 (0%)
Query: 1 MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
Sbjct: 1 MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
Query: 61 WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC 120
WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC
Sbjct: 61 WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHLEFTMQEAVQC 120
Query: 121 LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR 180
LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR
Sbjct: 121 LHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVAEFIPADR 180
Query: 181 KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL 240
KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL
Sbjct: 181 KLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLCGNGCDDL 240
Query: 241 DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR 300
DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR
Sbjct: 241 DLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSPYPSSPMR 300
Query: 301 RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL 360
RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL
Sbjct: 301 RPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGVQNLSRSL 360
Query: 361 MLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNEL 420
MLENTECHSIYEESPER DTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNEL
Sbjct: 361 MLENTECHSIYEESPER-DTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPAKQEKNEL 419
Query: 421 RDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRS 480
RDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRS
Sbjct: 420 RDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLTEQFLNRS 479
Query: 481 IQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIH 540
IQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIH
Sbjct: 480 IQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLTHDASNIH 539
Query: 541 TSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVC 600
TSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVC
Sbjct: 540 TSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDKSKKQFVC 599
Query: 601 INILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKH 660
INILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKH
Sbjct: 600 INILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKH 659
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG
Sbjct: 660 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 719
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVR 780
PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVR
Sbjct: 720 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVR 779
Query: 781 FWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH 840
FWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH
Sbjct: 780 FWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYH 839
Query: 841 PHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQ 900
PHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQ
Sbjct: 840 PHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQ 899
Query: 901 DLSFLSSSADRTVTLWTYNG 920
DLSFLSSSADRTVTLWTYNG
Sbjct: 900 DLSFLSSSADRTVTLWTYNG 919
>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
Length = 927
Score = 1866 bits (4834), Expect = 0.0
Identities = 920/927 (99%), Positives = 920/927 (99%), Gaps = 7/927 (0%)
Query: 1 MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ
Sbjct: 1 MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGLFSDDMLFLRQLILDGQ 60
Query: 61 WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQH-------LEFT 113
WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQH LEFT
Sbjct: 61 WDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMSAEDEPQHVRFLFLKLEFT 120
Query: 114 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 173
MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA
Sbjct: 121 MQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTARVHCFEEACVMVA 180
Query: 174 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 233
EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC
Sbjct: 181 EFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGEEITESEVLLGIDLLC 240
Query: 234 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 293
GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP
Sbjct: 241 GNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPTKAAYADLLTPLISKLSP 300
Query: 294 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 353
YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV
Sbjct: 301 YPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDLGNKTSPMSHSFANFHYPGV 360
Query: 354 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 413
QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA
Sbjct: 361 QNLSRSLMLENTECHSIYEESPERSDTPVDAQRPIGSEILGQSSVSEKEPANGAQNPGPA 420
Query: 414 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 473
KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT
Sbjct: 421 KQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQQQNLT 480
Query: 474 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 533
EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT
Sbjct: 481 EQFLNRSIQKLGELNIGMDGLGNEVSALNQQCNGSKGNGSNGSSVTSFTTPPQDSSQRLT 540
Query: 534 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 593
HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK
Sbjct: 541 HDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEHSVIKPPLGDSPGSLSRSKGEEDDK 600
Query: 594 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 653
SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV
Sbjct: 601 SKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVV 660
Query: 654 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 713
RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR
Sbjct: 661 RFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIR 720
Query: 714 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 773
DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG
Sbjct: 721 DLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASG 780
Query: 774 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 833
SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG
Sbjct: 781 SQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGG 840
Query: 834 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 893
RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI
Sbjct: 841 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVI 900
Query: 894 QCRWHTQDLSFLSSSADRTVTLWTYNG 920
QCRWHTQDLSFLSSSADRTVTLWTYNG
Sbjct: 901 QCRWHTQDLSFLSSSADRTVTLWTYNG 927
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 110 bits (276), Expect = 5e-24
Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)
Query: 650 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 709
+P R R HK ++ CV +SP G LLA+GS DK V++ N G F H
Sbjct: 11 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 65
Query: 710 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 768
T+R + F S G ++A + D + R + L +LS H + A ++ G
Sbjct: 66 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 769 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 828
+I S S DKTV+ WD CV ++ G V V PSG +A D++ ++
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
Query: 829 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 887
D+R R++Q Y HS+ V + F P +YL+T S D +K+ DL +G L + +
Sbjct: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 231
Query: 888 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
H+ + F S +D V +W N
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 263
Score = 80.5 bits (197), Expect = 7e-15
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 609 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 668
AV V F P+G L A GS KT+R+ P+V S V R H ++ V
Sbjct: 25 AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 71
Query: 669 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 728
+ GQ T S+DK VKV + + S H +R F G ++
Sbjct: 72 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 122
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 787
+SA + D + D + +H+ H G + + + SG IA+ D TV+ WD+R
Sbjct: 123 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 788 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 847
++ + +AV ++ PSG L T DS+ + D+ GR++ + H H
Sbjct: 182 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 848 SVRFSPGAHYLLTGSYDMKIKV 869
+V FS Y +G D ++ V
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMV 259
Score = 42.0 bits (97), Expect = 0.003
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 822 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYD--MKIKVTDLQGDLTKQ 879
DS M++ ++ + H V V FSP H L +GS D ++I V +++G+ T
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST-- 59
Query: 880 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
V H V + + SF+++S D+TV +W
Sbjct: 60 ----VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 110 bits (276), Expect = 5e-24
Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)
Query: 650 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 709
+P R R HK ++ CV +SP G LLA+GS DK V++ N G F H
Sbjct: 49 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 103
Query: 710 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 768
T+R + F S G ++A + D + R + L +LS H + A ++ G
Sbjct: 104 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 769 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 828
+I S S DKTV+ WD CV ++ G V V PSG +A D++ ++
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Query: 829 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 887
D+R R++Q Y HS+ V + F P +YL+T S D +K+ DL +G L + +
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 269
Query: 888 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
H+ + F S +D V +W N
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 80.5 bits (197), Expect = 7e-15
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 609 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 668
AV V F P+G L A GS KT+R+ P+V S V R H ++ V
Sbjct: 63 AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 109
Query: 669 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 728
+ GQ T S+DK VKV + + S H +R F G ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 160
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 787
+SA + D + D + +H+ H G + + + SG IA+ D TV+ WD+R
Sbjct: 161 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 788 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 847
++ + +AV ++ PSG L T DS+ + D+ GR++ + H H
Sbjct: 220 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 848 SVRFSPGAHYLLTGSYDMKIKV 869
+V FS Y +G D ++ V
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMV 297
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 8/122 (6%)
Query: 797 FHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH 856
F G AV V + + LA+G DS M++ ++ + H V V FSP H
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 857 YLLTGSYD--MKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT 914
L +GS D ++I V +++G+ T V H V + + SF+++S D+TV
Sbjct: 75 LLASGSRDKTVRIWVPNVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 915 LW 916
+W
Sbjct: 129 VW 130
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 110 bits (276), Expect = 5e-24
Identities = 82/272 (30%), Positives = 125/272 (45%), Gaps = 21/272 (7%)
Query: 650 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHD 709
+P R R HK ++ CV +SP G LLA+GS DK V++ N G F H
Sbjct: 49 KPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VPNVKGESTVFRAHT 103
Query: 710 GTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGW 768
T+R + F S G ++A + D + R + L +LS H + A ++ G
Sbjct: 104 ATVRSVHFC----SDGQSFVTA-SDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 158
Query: 769 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLY 828
+I S S DKTV+ WD CV ++ G V V PSG +A D++ ++
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVH----SYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 214
Query: 829 DIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDL-QGDLTKQLPIMVVGE 887
D+R R++Q Y HS+ V + F P +YL+T S D +K+ DL +G L + +
Sbjct: 215 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRL-----LYTLHG 269
Query: 888 HKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
H+ + F S +D V +W N
Sbjct: 270 HQGPATTVAFSRTGEYFASGGSDEQVMVWKSN 301
Score = 80.5 bits (197), Expect = 7e-15
Identities = 72/262 (27%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 609 AVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCV 668
AV V F P+G L A GS KT+R+ P+V S V R H ++ V
Sbjct: 63 AVTCVNFSPSGHLLASGSRDKTVRIWV-PNVKGEST-------VFR-----AHTATVRSV 109
Query: 669 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 728
+ GQ T S+DK VKV + + S H +R F G ++
Sbjct: 110 HFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKF----SPDGRLI 160
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVP 787
+SA + D + D + +H+ H G + + + SG IA+ D TV+ WD+R
Sbjct: 161 VSA-SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 788 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVR 847
++ + +AV ++ PSG L T DS+ + D+ GR++ + H H
Sbjct: 220 RLLQ----HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 848 SVRFSPGAHYLLTGSYDMKIKV 869
+V FS Y +G D ++ V
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMV 297
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 8/122 (6%)
Query: 797 FHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH 856
F G AV V + + LA+G DS M++ ++ + H V V FSP H
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 857 YLLTGSYD--MKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT 914
L +GS D ++I V +++G+ T V H V + + SF+++S D+TV
Sbjct: 75 LLASGSRDKTVRIWVPNVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 915 LW 916
+W
Sbjct: 129 VW 130
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 101 bits (252), Expect = 3e-21
Identities = 79/273 (28%), Positives = 123/273 (45%), Gaps = 23/273 (8%)
Query: 650 QPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKV-LPFNAETCNATGPDLEFSMH 708
+P R R HK + V +SP G LLA+ S D+ V++ +P + G EF H
Sbjct: 48 KPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIP------DKRGKFSEFKAH 101
Query: 709 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSG 767
+R + F S ++ + D +I R + L++L HT + A ++ G
Sbjct: 102 TAPVRSVDF-----SADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDG 156
Query: 768 WMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCML 827
+I S S+DKT++ WD CV F + V +PSG +A+ D + +
Sbjct: 157 RLIVSCSEDKTIKIWDTTNKQCVN----NFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
Query: 828 YDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD-LQGDLTKQLPIMVVG 886
+D+R +++Q Y HS V + F P +YL+T S D +K+ D L+G L I +
Sbjct: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRL-----IYTLQ 267
Query: 887 EHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
H V + F S AD V LW N
Sbjct: 268 GHTGPVFTVSFSKGGELFASGGADTQVLLWRTN 300
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/279 (24%), Positives = 104/279 (37%), Gaps = 57/279 (20%)
Query: 596 KQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRF 655
+Q ++ T VR F P G L S KT+++ T KQ V F
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW----------DTTNKQCVNNF 182
Query: 656 KRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDL 715
+ G V ++P G +A+ +D+ VKV + +H G + +
Sbjct: 183 SDS---VGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ-----HYQVHSGGVNCI 234
Query: 716 AFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGS 774
+F G LI+A + D + D G+ ++ L GHTG + + ++ G + ASG
Sbjct: 235 SF----HPSGNYLITA-SSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGG 289
Query: 775 QDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGR 834
D V W R H G + R L DS L DI
Sbjct: 290 ADTQVLLW--------RTNFDELHCKGL---------TKRNLKRLHFDSPPHLLDI---- 328
Query: 835 MVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 873
++ HPH V +V +P K++V DLQ
Sbjct: 329 YPRTPHPHEEKVETVEINP------------KLEVIDLQ 355
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/123 (24%), Positives = 57/123 (46%), Gaps = 8/123 (6%)
Query: 797 FHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH 856
F G +A+ S+ + P+G+ LAT D+ ML++ + Y H V SV+FSP +
Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 857 YLLTGSYDMKIK--VTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT 914
L + S D ++ + D +G ++ H V + ++S D+++
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSE------FKAHTAPVRSVDFSADGQFLATASEDKSIK 127
Query: 915 LWT 917
+W+
Sbjct: 128 VWS 130
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 100 bits (250), Expect = 5e-21
Identities = 86/321 (26%), Positives = 140/321 (43%), Gaps = 38/321 (11%)
Query: 601 INILEDTQ-AVRAVAFH-PAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRN 658
+N LE + V A+AF+ P G A GS KT ++ + ET K +
Sbjct: 127 LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV---------ETGKC----YHTF 173
Query: 659 KHHKGSIYCVAWSPCGQLLATGSNDKYVKV--LPFNAETCNATGPDLEFSMHDGTIRDLA 716
+ H I C++++P L+ATGS D K+ + E G H I L+
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG-------HSAEIISLS 226
Query: 717 FMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQ 775
F SG I+ G+ D + D G+ ++ L GH I A + W +I +GS
Sbjct: 227 FNT---SGDRII--TGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSM 281
Query: 776 DKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRM 835
DKT + WD CV T G + D +G+L+AT D + ++ +
Sbjct: 282 DKTCKLWDATNGKCV----ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKC 337
Query: 836 VQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQC 895
+ H ++ + F+P ++LLTGS D ++ D Q T Q + V+ H D++ C
Sbjct: 338 IAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ---TGQC-LQVLEGHTDEIFSC 393
Query: 896 RWHTQDLSFLSSSADRTVTLW 916
++ + ++ S D T +W
Sbjct: 394 AFNYKGNIVITGSKDNTCRIW 414
Score = 82.4 bits (202), Expect = 2e-15
Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 12/197 (6%)
Query: 722 ESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTG--HILALYTWSGWMIASGSQDKTV 779
+SG + + C ++ D G+ L+ L GH + +A G IA+GS DKT
Sbjct: 102 KSGSCFITGSYDRTCKLW--DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTC 159
Query: 780 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 839
+ W + C TF G + + ++ +P L+ATG D++ L+DI+ G V +
Sbjct: 160 KLWSVETGKCYH----TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 840 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHT 899
HS+++ S+ F+ ++TGS+D + V D D +++ I++ H ++ ++
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWD--ADTGRKVNILI--GHCAEISSASFNW 271
Query: 900 QDLSFLSSSADRTVTLW 916
L+ S D+T LW
Sbjct: 272 DCSLILTGSMDKTCKLW 288
Score = 42.0 bits (97), Expect = 0.003
Identities = 27/114 (23%), Positives = 50/114 (43%), Gaps = 5/114 (4%)
Query: 804 VASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRF-SPGAHYLLTGS 862
+ +VA++ SG TG D +C L+D G + + H + V ++ F +P + TGS
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 863 YDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
+D K+ ++ H +++ ++ Q + S D T LW
Sbjct: 155 FDKTCKLWSVETGKCYH----TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 95.5 bits (236), Expect = 2e-19
Identities = 65/213 (30%), Positives = 104/213 (48%), Gaps = 12/213 (5%)
Query: 705 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALY 763
F H G + AF G +L++ C +Y + + GQ L L GHTG + +
Sbjct: 17 FGQHGGEVNSSAF----SPDGQMLLTGSEDGC-VYGWETRSGQLLWRLGGHTGPVKFCRF 71
Query: 764 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 823
+ G + AS S D TVR WD+ C+RV+ G +V +V+ P R LA+G D
Sbjct: 72 SPDGHLFASASCDCTVRLWDVARAKCLRVL----KGHQRSVETVSFSPDSRQLASGGWDK 127
Query: 824 SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 883
ML+D++ G+M++ H ++S FSP + L TGS+D + + DL+ +T +
Sbjct: 128 RVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR-MVTPAVSHQ 186
Query: 884 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
+ H I C ++ S S D+T+ +W
Sbjct: 187 ALEGHSAN-ISCLCYSASGLLASGSWDKTIHIW 218
Score = 63.2 bits (152), Expect = 1e-09
Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 13/212 (6%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H G + +SP G L A+ S D V++ C H ++ ++F
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRV-----LKGHQRSVETVSF--S 114
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 779
P+S +++G D + D Q GQ L L GH I + ++ + +A+GS D TV
Sbjct: 115 PDSRQ---LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171
Query: 780 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 839
WDLR+ + V G + ++ + SG LLA+G D + ++ ++
Sbjct: 172 HIWDLRMVTPA-VSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL 229
Query: 840 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
H + V+S+ FSP +L + Y +KV D
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 261
Score = 40.4 bits (93), Expect = 0.008
Identities = 30/84 (35%), Positives = 39/84 (46%), Gaps = 6/84 (7%)
Query: 834 RMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVGEHKDKV 892
R V+ + H +V S FSP LLTGS D + + + G L +L G H V
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-----GGHTGPV 66
Query: 893 IQCRWHTQDLSFLSSSADRTVTLW 916
CR+ F S+S D TV LW
Sbjct: 67 KFCRFSPDGHLFASASCDCTVRLW 90
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 94.7 bits (234), Expect = 3e-19
Identities = 80/273 (29%), Positives = 116/273 (42%), Gaps = 24/273 (8%)
Query: 655 FKRNKHHKGSIYCV-----AWSPCGQLLATGSNDKYVKVLPFNAETC-NATGPDLEFSMH 708
F NK H ++ C A++P G +A G D V P + N +MH
Sbjct: 93 FTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH 152
Query: 709 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALY---TW 765
+ +F S IL ++G G C ++ D + GQ L + GH +L L +
Sbjct: 153 TNYLSACSFTN---SDMQILTASGDGTCALW--DVESGQLLQSFHGHGADVLCLDLAPSE 207
Query: 766 SGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSC 825
+G SG DK WD+R CV+ F S + SV PSG A+G +D++C
Sbjct: 208 TGNTFVSGGCDKKAMVWDMRSGQCVQA----FETHESDINSVRYYPSGDAFASGSDDATC 263
Query: 826 MLYDIRGGRMVQSYHPHSS--DVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 883
LYD+R R V Y S SV FS L G D I V D+ K +
Sbjct: 264 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV----LKGSRVS 319
Query: 884 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
++ H+++V R +F S S D T+ +W
Sbjct: 320 ILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/234 (26%), Positives = 109/234 (46%), Gaps = 20/234 (8%)
Query: 650 QPVVRFKRN-KHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMH 708
Q V++ +R K H + C+ W + + + S D KV+ +++ T N E ++
Sbjct: 50 QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDG--KVIVWDSFTTNK-----EHAVT 102
Query: 709 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHA----LSGHTGHILAL-Y 763
+A P SG AI C++Y + + + A ++ HT ++ A +
Sbjct: 103 MPCTWVMACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF 161
Query: 764 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPS--GRLLATGQE 821
T S I + S D T WD+ ++ +FHG G+ V + + PS G +G
Sbjct: 162 TNSDMQILTASGDGTCALWDVESGQLLQ----SFHGHGADVLCLDLAPSETGNTFVSGGC 217
Query: 822 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 875
D M++D+R G+ VQ++ H SD+ SVR+ P +GS D ++ DL+ D
Sbjct: 218 DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD 271
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 94.7 bits (234), Expect = 3e-19
Identities = 80/273 (29%), Positives = 116/273 (42%), Gaps = 24/273 (8%)
Query: 655 FKRNKHHKGSIYCV-----AWSPCGQLLATGSNDKYVKVLPFNAETC-NATGPDLEFSMH 708
F NK H ++ C A++P G +A G D V P + N +MH
Sbjct: 135 FTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMH 194
Query: 709 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALY---TW 765
+ +F S IL ++G G C ++ D + GQ L + GH +L L +
Sbjct: 195 TNYLSACSFTN---SDMQILTASGDGTCALW--DVESGQLLQSFHGHGADVLCLDLAPSE 249
Query: 766 SGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSC 825
+G SG DK WD+R CV+ F S + SV PSG A+G +D++C
Sbjct: 250 TGNTFVSGGCDKKAMVWDMRSGQCVQA----FETHESDINSVRYYPSGDAFASGSDDATC 305
Query: 826 MLYDIRGGRMVQSYHPHSS--DVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 883
LYD+R R V Y S SV FS L G D I V D+ K +
Sbjct: 306 RLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDV----LKGSRVS 361
Query: 884 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
++ H+++V R +F S S D T+ +W
Sbjct: 362 ILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 76.6 bits (187), Expect = 1e-13
Identities = 63/234 (26%), Positives = 109/234 (46%), Gaps = 20/234 (8%)
Query: 650 QPVVRFKRN-KHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMH 708
Q V++ +R K H + C+ W + + + S D KV+ +++ T N E ++
Sbjct: 92 QFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDG--KVIVWDSFTTNK-----EHAVT 144
Query: 709 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHA----LSGHTGHILAL-Y 763
+A P SG AI C++Y + + + A ++ HT ++ A +
Sbjct: 145 MPCTWVMACAYAP-SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSF 203
Query: 764 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPS--GRLLATGQE 821
T S I + S D T WD+ ++ +FHG G+ V + + PS G +G
Sbjct: 204 TNSDMQILTASGDGTCALWDVESGQLLQ----SFHGHGADVLCLDLAPSETGNTFVSGGC 259
Query: 822 DSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 875
D M++D+R G+ VQ++ H SD+ SVR+ P +GS D ++ DL+ D
Sbjct: 260 DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRAD 313
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 91.7 bits (226), Expect = 3e-18
Identities = 61/201 (30%), Positives = 96/201 (47%), Gaps = 15/201 (7%)
Query: 674 GQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGA 733
G+LLATG +D V + N C + + H + + + PE LI AG+
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCI-----MSLTGHTSPVESVR-LNTPEE----LIVAGS 82
Query: 734 GDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRV 792
+I D + + L L GH +I +L + G +ASGSQD ++ WD+R CV
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCV-- 140
Query: 793 VGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFS 852
+ G AV + P G+ LA+ +D + L+D+ G+M+ + H+ V V F
Sbjct: 141 --FRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198
Query: 853 PGAHYLLTGSYDMKIKVTDLQ 873
P + L +GS D I+ DL+
Sbjct: 199 PNEYLLASGSSDRTIRFWDLE 219
Score = 87.4 bits (215), Expect = 5e-17
Identities = 55/191 (28%), Positives = 91/191 (47%), Gaps = 11/191 (5%)
Query: 728 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRV 786
L++ G DC + + + +L+GHT + ++ +I +GSQ ++R WDL
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
Query: 787 PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 846
+R T G + + S+ P G +A+G +D++ L+DIR V Y HS V
Sbjct: 95 AKILR----TLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAV 150
Query: 847 RSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 905
R +RFSP +L + + D +K+ DL G + + P H V +H +
Sbjct: 151 RCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP-----GHTGPVNVVEFHPNEYLLA 205
Query: 906 SSSADRTVTLW 916
S S+DRT+ W
Sbjct: 206 SGSSDRTIRFW 216
Score = 49.3 bits (116), Expect = 2e-05
Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 4/105 (3%)
Query: 812 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
SGRLLATG +D L+ I + S H+S V SVR + ++ GS I+V D
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
Query: 872 LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
L+ K L ++ HK + +H S S D + LW
Sbjct: 92 LEA--AKILRTLM--GHKANICSLDFHPYGEFVASGSQDTNIKLW 132
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 91.7 bits (226), Expect = 3e-18
Identities = 62/262 (23%), Positives = 119/262 (45%), Gaps = 20/262 (7%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H+G +YC + P G LA+ D+ + + + N H G + +L +
Sbjct: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYA----TLKGHSGAVMELHY--- 117
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALY--TWSGWMIASGSQDKT 778
+ G++L SA D + D + G+ + L GHT + + Y ++ +GS D T
Sbjct: 118 -NTDGSMLFSAST-DKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
Query: 779 VRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQS 838
V+ WD+R + ++ TF T +A D S +++ +G D+ ++D+R ++ +
Sbjct: 176 VKLWDIRKKAAIQ----TFQNTYQVLAVTFNDTSDQII-SGGIDNDIKVWDLRQNKLTYT 230
Query: 839 YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMV----VGEHKDKVIQ 894
H+ V + S YLL+ + D ++V D++ K+ + + V + +++
Sbjct: 231 MRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR 290
Query: 895 CRWHTQDLSFLSSSADRTVTLW 916
C W + SADR V +W
Sbjct: 291 CSWSPDGSKIAAGSADRFVYVW 312
Score = 59.7 bits (143), Expect = 1e-08
Identities = 54/226 (23%), Positives = 90/226 (39%), Gaps = 17/226 (7%)
Query: 654 RFKRNKHHKGSIY-CVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTI 712
R KR K H + C QL+ TGS+D VK+ + T T
Sbjct: 143 RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT--------FQNTY 194
Query: 713 RDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWS-GWMIA 771
+ LA S I +G D +I D ++ + + + GH + L S G +
Sbjct: 195 QVLAVTFNDTSDQII---SGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLL 251
Query: 772 SGSQDKTVRFWDLRV----PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCML 827
S + D TVR WD+R CV++ H + + P G +A G D +
Sbjct: 252 SNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311
Query: 828 YDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 873
+D R++ H+ + V F P +++ S D ++ + ++Q
Sbjct: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 34.7 bits (78), Expect = 0.42
Identities = 14/42 (33%), Positives = 23/42 (54%)
Query: 879 QLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYNG 920
Q PIM++ H+ +V C++H + S+ DR + LW G
Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYG 97
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 85.9 bits (211), Expect = 2e-16
Identities = 126/546 (23%), Positives = 217/546 (39%), Gaps = 87/546 (15%)
Query: 412 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 468
P + E + D T Q QE + R+++Q+ L + ++R Q++++ NQ D+
Sbjct: 64 PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122
Query: 469 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 511
+ + E + +Q KL +L L +E AL +G
Sbjct: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
Query: 512 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 569
N VT + + RL +A N S R + + P + +
Sbjct: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
Query: 570 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVA-------FHPAGGLY 622
VI D E+T VRA++ PAGGL
Sbjct: 241 EVIVDETSDHT------------------------EETSPVRAISRAATKRLSQPAGGLL 276
Query: 623 AVGSNSKTLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQL 676
+N R V ++P D +D P + + + P H G + V +SP +L
Sbjct: 277 DSITNIFGRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRL 336
Query: 677 LATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDC 736
LATG D+ VK+ E C G G+ + +E +G +L ++
Sbjct: 337 LATGGMDRRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFAS 390
Query: 737 NIYTTDCQRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGT 795
I+T D R + H L+GH+G +L A + I SGS D+T++ WDLR C++ V
Sbjct: 391 RIWTVDDYRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-- 446
Query: 796 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 855
GS+ + + + + +G D +DIR +V+ + ++ +P
Sbjct: 447 ---FAGSSCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPER 500
Query: 856 HYLLTGSYDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADR 911
LL+ S D +KV DL+ + KQ P G +V+ + D S++++ SA+
Sbjct: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEG 556
Query: 912 TVTLWT 917
++ +W+
Sbjct: 557 SLYIWS 562
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 83.6 bits (205), Expect = 8e-16
Identities = 63/213 (29%), Positives = 97/213 (45%), Gaps = 17/213 (7%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H G +Y ++SP L + S D V++ TC + + H+ + D F
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCL-----VGYKGHNYPVWDTQF--- 593
Query: 721 PESGGAILISAGAGD-CNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGWMIASGSQDKT 778
G +S G ++ TD Q L +GH + + + +A+GS D+T
Sbjct: 594 -SPYGYYFVSGGHDRVARLWATD--HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRT 650
Query: 779 VRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQS 838
VR WD+ +CVR+ F G + S+ P+GR LATG D +L+DI G MV
Sbjct: 651 VRLWDVLNGNCVRI----FTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706
Query: 839 YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
H+ V S+RFS L +GS D +++ D
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 68.2 bits (165), Expect = 3e-11
Identities = 59/228 (25%), Positives = 93/228 (40%), Gaps = 27/228 (11%)
Query: 703 LEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRG-------QGLHALSGH 755
LE M + T +L + G G + ++ + D N + + G Q L G+
Sbjct: 524 LERIMDEKTASELKILYG--HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 756 TGHILALYTWS----GWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDP 811
GH ++ G+ SG D+ R W +R+ F G + V P
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI----FAGHLADVNCTRFHP 637
Query: 812 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
+ +ATG D + L+D+ G V+ + H + S+ FSP +L TG+ D ++ + D
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWD 697
Query: 872 LQGDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
+ L +VGE H D V R+ S S D TV LW
Sbjct: 698 IGHGL-------MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 48.1 bits (113), Expect = 4e-05
Identities = 42/178 (23%), Positives = 65/178 (36%), Gaps = 37/178 (20%)
Query: 769 MIASGSQDKTVRFWDLRVPSCVRVVGTT----------------------------FHGT 800
+IA G D TVR W + P +R V +G
Sbjct: 484 LIAGGFADSTVRVWSV-TPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGH 542
Query: 801 GSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLT 860
V + P L + ED + L+ ++ + Y H+ V +FSP +Y ++
Sbjct: 543 SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVS 602
Query: 861 GSYD--MKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
G +D ++ TD P+ + H V R+H + SADRTV LW
Sbjct: 603 GGHDRVARLWATD------HYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
Score = 42.4 bits (98), Expect = 0.002
Identities = 45/175 (25%), Positives = 65/175 (37%), Gaps = 66/175 (37%)
Query: 610 VRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVA 669
V FHP A GS +T+R+ DV++ + VR HKG I+ +
Sbjct: 630 VNCTRFHPNSNYVATGSADRTVRLW---DVLNGNC--------VRIFTG--HKGPIHSLT 676
Query: 670 WSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILI 729
+SP G+ LATG+ D G +L+
Sbjct: 677 FSPNGRFLATGATD-----------------------------------------GRVLL 695
Query: 730 SAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWD 783
D G + L GHT + +L ++ G ++ASGS D TVR WD
Sbjct: 696 -----------WDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 83.6 bits (205), Expect = 8e-16
Identities = 88/346 (25%), Positives = 153/346 (44%), Gaps = 40/346 (11%)
Query: 582 SLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVC-AYPDVI 640
S S ++ +E ++ + ++ T+AV +V F P G A S + + + AY
Sbjct: 16 SSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKY 75
Query: 641 DPSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATG 700
+ + + H I VAWS L + S+DK +K+ + C T
Sbjct: 76 EKTLYG--------------HNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKT- 120
Query: 701 PDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHIL 760
H + F P S LI +G+ D + + + G+ L LS H+ +
Sbjct: 121 ----LKGHSNYVFCCNF--NPPSN---LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVS 171
Query: 761 AL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATG 819
A+ + SG +I SGS D R WD C++ T V+ V P+G+ + T
Sbjct: 172 AVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK---TLVDDDNPPVSFVKFSPNGKYILTA 228
Query: 820 QEDSSCMLYDIRGGRMVQSYHPHSSDVRSV--RFS-PGAHYLLTGSYDMKIKVTDLQGDL 876
D++ L+D GR +++Y H ++ + FS G ++++GS D + + +LQ
Sbjct: 229 TLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ--- 285
Query: 877 TKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSA---DRTVTLWTYN 919
TK++ + G H D VI H + + ++S+A D+T+ LW N
Sbjct: 286 TKEIVQKLQG-HTDVVISAACHPTE-NLIASAALENDKTIKLWMSN 329
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 83.2 bits (204), Expect = 1e-15
Identities = 84/318 (26%), Positives = 142/318 (44%), Gaps = 40/318 (12%)
Query: 607 TQAVRAVAFHPAGGLYAVGSNSKTLRVC-AYPDVIDPSAHETPKQPVVRFKRNKHHKGSI 665
T+AV +V F P G A S K +++ AY + K HK I
Sbjct: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--------------KTISGHKLGI 90
Query: 666 YCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGG 725
VAWS LL + S+DK +K+ ++ C T H + F P+S
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT-----LKGHSNYVFCCNF--NPQSN- 142
Query: 726 AILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDL 784
LI +G+ D ++ D + G+ L L H+ + A+ + G +I S S D R WD
Sbjct: 143 --LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 785 RVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 844
C++ T V+ V P+G+ + D++ L+D G+ +++Y H +
Sbjct: 201 ASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 845 DVRSV--RFS-PGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQD 901
+ + FS G ++++GS D + + +LQ TK++ + G H D VI H +
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ---TKEIVQKLQG-HTDVVISTACHPTE 313
Query: 902 LSFLSSSA---DRTVTLW 916
+ ++S+A D+T+ LW
Sbjct: 314 -NIIASAALENDKTIKLW 330
Score = 75.1 bits (183), Expect = 3e-13
Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 19/229 (8%)
Query: 647 TPKQP--VVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLE 704
TP +P ++F H K ++ V +SP G+ LA+ S DK +K+ T
Sbjct: 29 TPVKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT----- 82
Query: 705 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 763
S H I D+A+ S +L+SA + D + D G+ L L GH+ ++ +
Sbjct: 83 ISGHKLGISDVAW----SSDSNLLVSA-SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137
Query: 764 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 823
+I SGS D++VR WD++ C++ T V++V + G L+ + D
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLK----TLPAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 824 SCMLYDIRGGRMVQS-YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
C ++D G+ +++ + V V+FSP Y+L + D +K+ D
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Score = 64.3 bits (155), Expect = 5e-10
Identities = 42/169 (24%), Positives = 79/169 (46%), Gaps = 13/169 (7%)
Query: 756 TGHILAL--YTWSGW--MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDP 811
+GH L + WS ++ S S DKT++ WD+ C++ T G + V +P
Sbjct: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK----TLKGHSNYVFCCNFNP 139
Query: 812 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
L+ +G D S ++D++ G+ +++ HS V +V F+ +++ SYD ++ D
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 872 -LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
G K L + + V ++ L+++ D T+ LW Y+
Sbjct: 200 TASGQCLKTL----IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Score = 63.5 bits (153), Expect = 8e-10
Identities = 41/167 (24%), Positives = 81/167 (48%), Gaps = 11/167 (6%)
Query: 752 LSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVD 810
L+GHT + ++ ++ +G +AS S DK ++ W + T G ++ VA
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK----TISGHKLGISDVAWS 96
Query: 811 PSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVT 870
LL + +D + ++D+ G+ +++ HS+ V F+P ++ +++GS+D +++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 871 DLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
D++ G K LP H D V ++ +SSS D +W
Sbjct: 157 DVKTGKCLKTLP-----AHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 83.2 bits (204), Expect = 1e-15
Identities = 84/318 (26%), Positives = 142/318 (44%), Gaps = 40/318 (12%)
Query: 607 TQAVRAVAFHPAGGLYAVGSNSKTLRVC-AYPDVIDPSAHETPKQPVVRFKRNKHHKGSI 665
T+AV +V F P G A S K +++ AY + K HK I
Sbjct: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--------------KTISGHKLGI 90
Query: 666 YCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGG 725
VAWS LL + S+DK +K+ ++ C T H + F P+S
Sbjct: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKT-----LKGHSNYVFCCNF--NPQSN- 142
Query: 726 AILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDL 784
LI +G+ D ++ D + G+ L L H+ + A+ + G +I S S D R WD
Sbjct: 143 --LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 785 RVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSS 844
C++ T V+ V P+G+ + D++ L+D G+ +++Y H +
Sbjct: 201 ASGQCLK---TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN 257
Query: 845 DVRSV--RFS-PGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQD 901
+ + FS G ++++GS D + + +LQ TK++ + G H D VI H +
Sbjct: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ---TKEIVQKLQG-HTDVVISTACHPTE 313
Query: 902 LSFLSSSA---DRTVTLW 916
+ ++S+A D+T+ LW
Sbjct: 314 -NIIASAALENDKTIKLW 330
Score = 75.1 bits (183), Expect = 3e-13
Identities = 62/229 (27%), Positives = 107/229 (46%), Gaps = 19/229 (8%)
Query: 647 TPKQP--VVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLE 704
TP +P ++F H K ++ V +SP G+ LA+ S DK +K+ T
Sbjct: 29 TPVKPNYALKFTLAGHTK-AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT----- 82
Query: 705 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 763
S H I D+A+ S +L+SA + D + D G+ L L GH+ ++ +
Sbjct: 83 ISGHKLGISDVAW----SSDSNLLVSA-SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137
Query: 764 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 823
+I SGS D++VR WD++ C++ T V++V + G L+ + D
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLK----TLPAHSDPVSAVHFNRDGSLIVSSSYDG 193
Query: 824 SCMLYDIRGGRMVQS-YHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
C ++D G+ +++ + V V+FSP Y+L + D +K+ D
Sbjct: 194 LCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Score = 64.3 bits (155), Expect = 5e-10
Identities = 42/169 (24%), Positives = 79/169 (46%), Gaps = 13/169 (7%)
Query: 756 TGHILAL--YTWSGW--MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDP 811
+GH L + WS ++ S S DKT++ WD+ C++ T G + V +P
Sbjct: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLK----TLKGHSNYVFCCNFNP 139
Query: 812 SGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTD 871
L+ +G D S ++D++ G+ +++ HS V +V F+ +++ SYD ++ D
Sbjct: 140 QSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
Query: 872 -LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTYN 919
G K L + + V ++ L+++ D T+ LW Y+
Sbjct: 200 TASGQCLKTL----IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244
Score = 63.5 bits (153), Expect = 8e-10
Identities = 41/167 (24%), Positives = 81/167 (48%), Gaps = 11/167 (6%)
Query: 752 LSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVD 810
L+GHT + ++ ++ +G +AS S DK ++ W + T G ++ VA
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK----TISGHKLGISDVAWS 96
Query: 811 PSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVT 870
LL + +D + ++D+ G+ +++ HS+ V F+P ++ +++GS+D +++
Sbjct: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
Query: 871 DLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
D++ G K LP H D V ++ +SSS D +W
Sbjct: 157 DVKTGKCLKTLP-----AHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 82.8 bits (203), Expect = 1e-15
Identities = 63/219 (28%), Positives = 95/219 (43%), Gaps = 18/219 (8%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H IY + W +LL + S D K++ +++ T N MH +R M
Sbjct: 54 HLAKIYAMHWGYDSRLLVSASQDG--KLIIWDSYTTN--------KMHAIPLRSSWVMTC 103
Query: 721 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 776
+ ++ G D C+IY + G + L GHTG++ I + S D
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGD 163
Query: 777 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 836
T WD+ TTF G V S+++ P R +G D+S L+DIR G
Sbjct: 164 TTCALWDIETAQQT----TTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCR 219
Query: 837 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 875
QS+ H SD+ +V F P + TGS D ++ DL+ D
Sbjct: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRAD 258
Score = 56.6 bits (135), Expect = 1e-07
Identities = 52/210 (24%), Positives = 90/210 (42%), Gaps = 14/210 (6%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H G + C + Q++ T S D + ++ ET T F+ H G + L+
Sbjct: 142 HTGYLSCCRFLDDSQIV-TSSGDTTCAL--WDIETAQQT---TTFTGHSGDVMSLSLSPD 195
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTV 779
+ +GA D + D + G + +GH I A+ + +G+ A+GS D T
Sbjct: 196 MRT-----FVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250
Query: 780 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 839
R +DLR ++ + + SVA SGRLL G +D +C ++D G
Sbjct: 251 RLFDLRADQ--ELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVL 308
Query: 840 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKV 869
H + V + + + TGS+D +++
Sbjct: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLRI 338
Score = 48.1 bits (113), Expect = 4e-05
Identities = 34/124 (27%), Positives = 55/124 (44%), Gaps = 9/124 (7%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H I V++ P G ATGS+D ++ A+ +L HD I + +
Sbjct: 225 HVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQ------ELLLYSHDNIICGITSVAF 278
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 779
+SG +L +CN++ D +G L+GH + L T G +A+GS D +
Sbjct: 279 SKSGRLLLAGYDDFNCNVW--DTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFL 336
Query: 780 RFWD 783
R W+
Sbjct: 337 RIWN 340
Score = 47.0 bits (110), Expect = 8e-05
Identities = 37/154 (24%), Positives = 69/154 (44%), Gaps = 4/154 (2%)
Query: 728 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRV 786
L+ + + D + D +HA+ + ++ Y SG +A G D ++L+
Sbjct: 69 LLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKT 128
Query: 787 -PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSD 845
VRV TG +D S + ++G D++C L+DI + ++ HS D
Sbjct: 129 REGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSG--DTTCALWDIETAQQTTTFTGHSGD 186
Query: 846 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQ 879
V S+ SP ++G+ D K+ D++ + +Q
Sbjct: 187 VMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQ 220
Score = 34.3 bits (77), Expect = 0.55
Identities = 26/106 (24%), Positives = 48/106 (45%), Gaps = 7/106 (6%)
Query: 814 RLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 873
RLL + +D +++D + + SS V + ++P +Y+ G D + +L+
Sbjct: 68 RLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLK 127
Query: 874 GDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
T++ + V E H + CR+ D ++SS D T LW
Sbjct: 128 ---TREGNVRVSRELPGHTGYLSCCRF-LDDSQIVTSSGDTTCALW 169
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 80.9 bits (198), Expect = 5e-15
Identities = 122/539 (22%), Positives = 212/539 (39%), Gaps = 92/539 (17%)
Query: 412 PAKQEKNELRDST---EQFQEYYRQRLRYQQHLEQKEQQRQIYQQMLLEGGVNQEDGPDQ 468
P + E + D T Q QE + R+++Q+ L + ++R Q++++ NQ D+
Sbjct: 64 PNRHEISPGHDGTWNDNQLQEMAQLRIKHQEELTELHKKRGELAQLVIDLN-NQMQRKDR 122
Query: 469 QQNLTEQFLNRSIQ--------------KLGELNIGMDGLGNEVSALNQQCNGSKGN--- 511
+ + E + +Q KL +L L +E AL +G
Sbjct: 123 EMQMNEAKIAECLQTISDLETECLDLRTKLCDLERANQTLKDEYDALQITFTALEGKLRK 182
Query: 512 --GSNGSSVTSFTTPPQDSSQRLTHDASNIHTSTPRNPGSTNHIPFLEESPCGSQISSEH 569
N VT + + RL +A N S R + + P + +
Sbjct: 183 TTEENQELVTRWMAEKAQEANRL--NAENEKDSRRRQARLQKELAEAAKEPLPVEQDDDI 240
Query: 570 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSK 629
VI D E+T VRA+ S +
Sbjct: 241 EVIVDETSDHT------------------------EETSPVRAI------------SRAA 264
Query: 630 TLR-VCAYP---DVID--PSAHETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSND 683
T R V ++P D +D P + + + P H G + V +SP +LLATG D
Sbjct: 265 TRRSVSSFPVPQDNVDTHPGSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMD 324
Query: 684 KYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDC 743
+ VK+ E C G G+ + +E +G +L ++ I+T D
Sbjct: 325 RRVKLWEVFGEKCEFKG------SLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDD 378
Query: 744 QRGQGLHALSGHTGHIL-ALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGS 802
R + H L+GH+G +L A + I SGS D+T++ WDLR C++ V GS
Sbjct: 379 YRLR--HTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTV-----FAGS 431
Query: 803 AVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGS 862
+ + + + + +G D +DIR +V+ + ++ +P LL+ S
Sbjct: 432 SCNDIVC--TEQCVMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCS 488
Query: 863 YDMKIKVTDLQGDLTKQ---LPIMVVGEHKDKVIQCRWHTQDLSFLSS-SADRTVTLWT 917
D +KV DL+ + KQ P G +V+ + D S++++ SA+ ++ +W+
Sbjct: 489 RDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVV----FSPDGSYVAAGSAEGSLYIWS 543
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 80.5 bits (197), Expect = 7e-15
Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 18/219 (8%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H IY + W +LL + S D K++ +++ T N +H +R M
Sbjct: 54 HLAKIYAMHWGTDSRLLVSASQDG--KLIIWDSYTTN--------KVHAIPLRSSWVMTC 103
Query: 721 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 776
+ ++ G D C+IY + G + L+GHTG++ I + S D
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGD 163
Query: 777 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 836
T WD+ TTF G V S+++ P RL +G D+S L+D+R G
Sbjct: 164 TTCALWDIETGQQT----TTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCR 219
Query: 837 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 875
Q++ H SD+ ++ F P + TGS D ++ DL+ D
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD 258
Score = 78.2 bits (191), Expect = 3e-14
Identities = 66/253 (26%), Positives = 112/253 (44%), Gaps = 22/253 (8%)
Query: 669 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 728
A++P G +A G D + N E + H G + F++ + I+
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVR-VSRELAGHTGYLSCCRFLDDNQ----IV 158
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGW-MIASGSQDKTVRFWDLRVP 787
S+G C ++ D + GQ +GHTG +++L + SG+ D + + WD+R
Sbjct: 159 TSSGDTTCALW--DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREG 216
Query: 788 SCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHS--SD 845
C + TF G S + ++ P+G ATG +D++C L+D+R + + +Y +
Sbjct: 217 MCRQ----TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICG 272
Query: 846 VRSVRFSPGAHYLLTGSYDMKIKVTD-LQGDLTKQLPIMVVGEHKDKVIQCRWHTQD-LS 903
+ SV FS LL G D V D L+ D V+ H D + C T D ++
Sbjct: 273 ITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAG-----VLAGH-DNRVSCLGVTDDGMA 326
Query: 904 FLSSSADRTVTLW 916
+ S D + +W
Sbjct: 327 VATGSWDSFLKIW 339
Score = 47.0 bits (110), Expect = 8e-05
Identities = 42/177 (23%), Positives = 80/177 (45%), Gaps = 17/177 (9%)
Query: 705 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 763
++MH GT D + G ++I + YTT+ +HA+ + ++ Y
Sbjct: 59 YAMHWGT--DSRLLVSASQDGKLII------WDSYTTN-----KVHAIPLRSSWVMTCAY 105
Query: 764 TWSGWMIASGSQDKTVRFWDLRV-PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQED 822
SG +A G D ++L+ VRV TG +D + + ++G D
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG--D 163
Query: 823 SSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQ 879
++C L+DI G+ ++ H+ DV S+ +P ++G+ D K+ D++ + +Q
Sbjct: 164 TTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220
Score = 35.4 bits (80), Expect = 0.25
Identities = 29/124 (23%), Positives = 54/124 (43%), Gaps = 7/124 (5%)
Query: 796 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 855
T G + + ++ RLL + +D +++D V + SS V + ++P
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 856 HYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRT 912
+Y+ G D + +L+ T++ + V E H + CR+ D ++SS D T
Sbjct: 110 NYVACGGLDNICSIYNLK---TREGNVRVSRELAGHTGYLSCCRF-LDDNQIVTSSGDTT 165
Query: 913 VTLW 916
LW
Sbjct: 166 CALW 169
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 78.2 bits (191), Expect = 3e-14
Identities = 60/219 (27%), Positives = 97/219 (44%), Gaps = 18/219 (8%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H IY + W +LL + S D K++ +++ T N +H +R M
Sbjct: 54 HLAKIYAMHWGTDSRLLVSASQDG--KLIIWDSYTTN--------KVHAIPLRSSWVMTC 103
Query: 721 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 776
+ ++ G D C+IY+ + G + L GHTG++ I + S D
Sbjct: 104 AYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGD 163
Query: 777 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 836
T WD+ + VG F G V S+++ P GR +G D+S L+D+R
Sbjct: 164 TTCALWDIETGQ--QTVG--FAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCR 219
Query: 837 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 875
Q++ H SD+ +V F P + TGS D ++ DL+ D
Sbjct: 220 QTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRAD 258
Score = 55.8 bits (133), Expect = 2e-07
Identities = 55/210 (26%), Positives = 91/210 (43%), Gaps = 14/210 (6%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H G + C + Q++ T S D + ++ ET T + F+ H G + L+
Sbjct: 142 HTGYLSCCRFLDDNQII-TSSGDTTCAL--WDIETGQQT---VGFAGHSGDVMSLSL--A 193
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTV 779
P+ G +S GA D +I D + GH I A+ + +G+ +GS D T
Sbjct: 194 PD--GRTFVS-GACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATC 250
Query: 780 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 839
R +DLR ++ + + SVA SGRLL G +D +C ++D G
Sbjct: 251 RLFDLRADQ--ELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVL 308
Query: 840 HPHSSDVRSVRFSPGAHYLLTGSYDMKIKV 869
H + V + + + TGS+D +K+
Sbjct: 309 AGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338
Score = 51.6 bits (122), Expect = 3e-06
Identities = 51/214 (23%), Positives = 92/214 (42%), Gaps = 21/214 (9%)
Query: 705 FSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-Y 763
++MH GT D + G ++I + YTT+ +HA+ + ++ Y
Sbjct: 59 YAMHWGT--DSRLLVSASQDGKLII------WDSYTTN-----KVHAIPLRSSWVMTCAY 105
Query: 764 TWSGWMIASGSQDKTVRFWDLRV-PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQED 822
SG +A G D + L+ VRV TG +D + + ++G D
Sbjct: 106 APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSG--D 163
Query: 823 SSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPI 882
++C L+DI G+ + HS DV S+ +P ++G+ D IK+ D++ + +Q I
Sbjct: 164 TTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFI 223
Query: 883 MVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
H+ + + +F + S D T L+
Sbjct: 224 ----GHESDINAVAFFPNGYAFTTGSDDATCRLF 253
Score = 33.9 bits (76), Expect = 0.71
Identities = 28/124 (22%), Positives = 53/124 (42%), Gaps = 7/124 (5%)
Query: 796 TFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGA 855
T G + + ++ RLL + +D +++D V + SS V + ++P
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 856 HYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGE---HKDKVIQCRWHTQDLSFLSSSADRT 912
+++ G D + L+ T++ + V E H + CR+ D ++SS D T
Sbjct: 110 NFVACGGLDNICSIYSLK---TREGNVRVSRELPGHTGYLSCCRF-LDDNQIITSSGDTT 165
Query: 913 VTLW 916
LW
Sbjct: 166 CALW 169
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 77.0 bits (188), Expect = 7e-14
Identities = 67/270 (24%), Positives = 123/270 (45%), Gaps = 23/270 (8%)
Query: 653 VRFKRNKHHKGSIYCVAWSPC----GQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMH 708
+ FK+ + H +I+ VAW + + TGS D VKV + E DL++S+
Sbjct: 7 ILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERL-----DLQWSLE 61
Query: 709 DGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHAL-SGHTGHILALYTWSG 767
L + S + ++ + D +I D + G+ + ++ +G ++
Sbjct: 62 G---HQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
Query: 768 WMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCML 827
+A+G+ V + + + T G + S+A P G+ LA+G D +
Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTR----GKFILSIAYSPDGKYLASGAIDGIINI 174
Query: 828 YDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVG 886
+DI G+++ + H+ +RS+ FSP + L+T S D IK+ D+Q +L L
Sbjct: 175 FDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTL-----S 229
Query: 887 EHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
H V+ + D F+SSS+D++V +W
Sbjct: 230 GHASWVLNVAFCPDDTHFVSSSSDKSVKVW 259
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 76.3 bits (186), Expect = 1e-13
Identities = 59/219 (26%), Positives = 94/219 (42%), Gaps = 18/219 (8%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H IY + W+ +LL + S D K++ +++ T N +H +R M
Sbjct: 54 HLAKIYAMHWATDSKLLVSASQDG--KLIVWDSYTTN--------KVHAIPLRSSWVMTC 103
Query: 721 PESGGAILISAGAGD--CNIYTTDCQRG--QGLHALSGHTGHILALYTWSGWMIASGSQD 776
+ ++ G D C+IY + G + LS HTG++ I + S D
Sbjct: 104 AYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGD 163
Query: 777 KTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV 836
T WD+ T F G S+AV P L +G D+S L+D+R G
Sbjct: 164 TTCALWDIETGQ----QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCR 219
Query: 837 QSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGD 875
Q++ H SD+ ++ F P + TGS D ++ DL+ D
Sbjct: 220 QTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRAD 258
Score = 53.1 bits (126), Expect = 1e-06
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 3/143 (2%)
Query: 728 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTVRFWDLRV 786
L +GA D + D + G +GH I A+ + +G I +GS D + R +DLR
Sbjct: 198 LFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA 257
Query: 787 PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 846
++ + + SVA SGRLL G +D +C ++D V H + V
Sbjct: 258 DQ--ELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRV 315
Query: 847 RSVRFSPGAHYLLTGSYDMKIKV 869
+ + + TGS+D +K+
Sbjct: 316 SCLGVTADGMAVATGSWDSFLKI 338
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/124 (25%), Positives = 55/124 (44%), Gaps = 9/124 (7%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H+ I + + P G+ + TGS+D ++ A+ +L H+ I + +
Sbjct: 225 HESDINAICFFPNGEAICTGSDDASCRLFDLRADQ------ELICFSHESIICGITSVAF 278
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 779
SG L+ AG D N D + + + LSGH + L T G +A+GS D +
Sbjct: 279 SLSGR--LLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFL 336
Query: 780 RFWD 783
+ W+
Sbjct: 337 KIWN 340
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/154 (22%), Positives = 68/154 (44%), Gaps = 4/154 (2%)
Query: 728 LISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLRV 786
L+ + + D + D +HA+ + ++ Y SG +A G D ++L+
Sbjct: 69 LLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKS 128
Query: 787 -PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSD 845
V+V TG +D + + ++G D++C L+DI G+ + H+ D
Sbjct: 129 REGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG--DTTCALWDIETGQQKTVFVGHTGD 186
Query: 846 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQ 879
S+ SP + ++G+ D K+ D++ +Q
Sbjct: 187 CMSLAVSPDFNLFISGACDASAKLWDVREGTCRQ 220
Score = 33.1 bits (74), Expect = 1.2
Identities = 22/103 (21%), Positives = 44/103 (42%), Gaps = 1/103 (0%)
Query: 814 RLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 873
+LL + +D +++D V + SS V + ++P +++ G D + +L+
Sbjct: 68 KLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLK 127
Query: 874 GDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
+ H + CR+ D + ++SS D T LW
Sbjct: 128 SREGNVKVSRELSAHTGYLSCCRF-LDDNNIVTSSGDTTCALW 169
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 73.9 bits (180), Expect = 6e-13
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 33/266 (12%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDG-TIRDLAFME 719
H GS+ C+ + +++ TGS+D V+V N TG L +H + L F
Sbjct: 279 HTGSVLCLQYDE--RVIVTGSSDSTVRVWDVN------TGEVLNTLIHHNEAVLHLRFSN 330
Query: 720 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYT--WSGWMIASGSQDK 777
G L+ + D +I D + GH A+ + I S S D+
Sbjct: 331 G-------LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 383
Query: 778 TVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 837
T++ W VR T +G +A + RL+ +G D++ L+DI G ++
Sbjct: 384 TIKVWSTSTCEFVR----TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLR 437
Query: 838 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLP-----IMVVGEHKDKV 892
H VR +RF +++G+YD KIKV DLQ L + P + + EH +V
Sbjct: 438 VLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 495
Query: 893 IQCRWHTQDLSFLSSSADRTVTLWTY 918
+ ++ + +SSS D T+ +W +
Sbjct: 496 FRLQF--DEFQIISSSHDDTILIWDF 519
Score = 58.5 bits (140), Expect = 3e-08
Identities = 41/148 (27%), Positives = 74/148 (50%), Gaps = 11/148 (7%)
Query: 770 IASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 829
I SG +D +++ WD C++V+ TG + + + R++ TG DS+ ++D
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWD 306
Query: 830 IRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHK 889
+ G ++ + H+ V +RFS G ++T S D I V D+ L ++VG H+
Sbjct: 307 VNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVG-HR 363
Query: 890 DKVIQCRWHTQDLSFLSSSADRTVTLWT 917
V + D +S+S DRT+ +W+
Sbjct: 364 AAVNVVDF--DDKYIVSASGDRTIKVWS 389
Score = 48.1 bits (113), Expect = 4e-05
Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 18/191 (9%)
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPS 788
I +G D +I D + L L+GHTG +L L + +I +GS D TVR WD+
Sbjct: 253 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYDERVIVTGSSDSTVRVWDVNTG- 310
Query: 789 CVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV---QSYHPHSSD 845
V+ T H A + + S L+ T +D S ++D+ + + H +
Sbjct: 311 --EVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 365
Query: 846 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 905
V V F Y+++ S D IKV T + + + HK + I C + +D +
Sbjct: 366 VNVVDFDD--KYIVSASGDRTIKVWSTS---TCEF-VRTLNGHK-RGIACLQY-RDRLVV 417
Query: 906 SSSADRTVTLW 916
S S+D T+ LW
Sbjct: 418 SGSSDNTIRLW 428
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 73.9 bits (180), Expect = 6e-13
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 33/266 (12%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDG-TIRDLAFME 719
H GS+ C+ + +++ TGS+D V+V N TG L +H + L F
Sbjct: 245 HTGSVLCLQYDE--RVIVTGSSDSTVRVWDVN------TGEVLNTLIHHNEAVLHLRFSN 296
Query: 720 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYT--WSGWMIASGSQDK 777
G L+ + D +I D + GH A+ + I S S D+
Sbjct: 297 G-------LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 349
Query: 778 TVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 837
T++ W VR T +G +A + RL+ +G D++ L+DI G ++
Sbjct: 350 TIKVWSTSTCEFVR----TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLR 403
Query: 838 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLP-----IMVVGEHKDKV 892
H VR +RF +++G+YD KIKV DLQ L + P + + EH +V
Sbjct: 404 VLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 461
Query: 893 IQCRWHTQDLSFLSSSADRTVTLWTY 918
+ ++ + +SSS D T+ +W +
Sbjct: 462 FRLQF--DEFQIISSSHDDTILIWDF 485
Score = 58.5 bits (140), Expect = 3e-08
Identities = 41/148 (27%), Positives = 74/148 (50%), Gaps = 11/148 (7%)
Query: 770 IASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 829
I SG +D +++ WD C++V+ TG + + + R++ TG DS+ ++D
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWD 272
Query: 830 IRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHK 889
+ G ++ + H+ V +RFS G ++T S D I V D+ L ++VG H+
Sbjct: 273 VNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVG-HR 329
Query: 890 DKVIQCRWHTQDLSFLSSSADRTVTLWT 917
V + D +S+S DRT+ +W+
Sbjct: 330 AAVNVVDF--DDKYIVSASGDRTIKVWS 355
Score = 48.1 bits (113), Expect = 4e-05
Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 18/191 (9%)
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPS 788
I +G D +I D + L L+GHTG +L L + +I +GS D TVR WD+
Sbjct: 219 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYDERVIVTGSSDSTVRVWDVNTG- 276
Query: 789 CVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV---QSYHPHSSD 845
V+ T H A + + S L+ T +D S ++D+ + + H +
Sbjct: 277 --EVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 331
Query: 846 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 905
V V F Y+++ S D IKV T + + + HK + I C + +D +
Sbjct: 332 VNVVDFDD--KYIVSASGDRTIKVWSTS---TCEF-VRTLNGHK-RGIACLQY-RDRLVV 383
Query: 906 SSSADRTVTLW 916
S S+D T+ LW
Sbjct: 384 SGSSDNTIRLW 394
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 73.9 bits (180), Expect = 6e-13
Identities = 70/266 (26%), Positives = 116/266 (43%), Gaps = 33/266 (12%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDG-TIRDLAFME 719
H GS+ C+ + +++ TGS+D V+V N TG L +H + L F
Sbjct: 266 HTGSVLCLQYDE--RVIVTGSSDSTVRVWDVN------TGEVLNTLIHHNEAVLHLRFSN 317
Query: 720 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYT--WSGWMIASGSQDK 777
G L+ + D +I D + GH A+ + I S S D+
Sbjct: 318 G-------LMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDR 370
Query: 778 TVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQ 837
T++ W VR T +G +A + RL+ +G D++ L+DI G ++
Sbjct: 371 TIKVWSTSTCEFVR----TLNGHKRGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLR 424
Query: 838 SYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLP-----IMVVGEHKDKV 892
H VR +RF +++G+YD KIKV DLQ L + P + + EH +V
Sbjct: 425 VLEGHEELVRCIRFD--NKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRV 482
Query: 893 IQCRWHTQDLSFLSSSADRTVTLWTY 918
+ ++ + +SSS D T+ +W +
Sbjct: 483 FRLQF--DEFQIISSSHDDTILIWDF 506
Score = 58.5 bits (140), Expect = 3e-08
Identities = 41/148 (27%), Positives = 74/148 (50%), Gaps = 11/148 (7%)
Query: 770 IASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYD 829
I SG +D +++ WD C++V+ TG + + + R++ TG DS+ ++D
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVL------TGHTGSVLCLQYDERVIVTGSSDSTVRVWD 293
Query: 830 IRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHK 889
+ G ++ + H+ V +RFS G ++T S D I V D+ L ++VG H+
Sbjct: 294 VNTGEVLNTLIHHNEAVLHLRFSNG--LMVTCSKDRSIAVWDMASATDITLRRVLVG-HR 350
Query: 890 DKVIQCRWHTQDLSFLSSSADRTVTLWT 917
V + D +S+S DRT+ +W+
Sbjct: 351 AAVNVVDF--DDKYIVSASGDRTIKVWS 376
Score = 48.1 bits (113), Expect = 4e-05
Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 18/191 (9%)
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPS 788
I +G D +I D + L L+GHTG +L L + +I +GS D TVR WD+
Sbjct: 240 IISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCL-QYDERVIVTGSSDSTVRVWDVNTG- 297
Query: 789 CVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMV---QSYHPHSSD 845
V+ T H A + + S L+ T +D S ++D+ + + H +
Sbjct: 298 --EVLNTLIHHN---EAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAA 352
Query: 846 VRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFL 905
V V F Y+++ S D IKV T + + + HK + I C + +D +
Sbjct: 353 VNVVDFDD--KYIVSASGDRTIKVWSTS---TCEF-VRTLNGHK-RGIACLQY-RDRLVV 404
Query: 906 SSSADRTVTLW 916
S S+D T+ LW
Sbjct: 405 SGSSDNTIRLW 415
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 72.0 bits (175), Expect = 2e-12
Identities = 79/325 (24%), Positives = 133/325 (40%), Gaps = 46/325 (14%)
Query: 610 VRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRN-KHHKGSIYCV 668
V V FHP + S T++V Y ET F+R K H S+ +
Sbjct: 111 VTRVIFHPVFSVMVSASEDATIKVWDY---------ETGD-----FERTLKGHTDSVQDI 156
Query: 669 AWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAIL 728
++ G+LLA+ S D +K+ F C T HD + +A M G +
Sbjct: 157 SFDHSGKLLASCSADMTIKLWDFQGFECIRT-----MHGHDHNVSSVAIM----PNGDHI 207
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHI-LALYTWSGWMIASGSQDKTVRFW----- 782
+SA + D I + Q G + +GH + + G +IAS S D+TVR W
Sbjct: 208 VSA-SRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK 266
Query: 783 ----DLR----VPSCVRVVGTTFHGTGSAVASVAVDPSGR---LLATGQEDSSCMLYDIR 831
+LR V C+ + + + S SG+ L +G D + ++D+
Sbjct: 267 ECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVS 326
Query: 832 GGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDK 891
G + + H + VR V F G ++L+ + D ++V D + + + + H+
Sbjct: 327 TGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYK----NKRCMKTLNAHEHF 382
Query: 892 VIQCRWHTQDLSFLSSSADRTVTLW 916
V +H ++ S D+TV +W
Sbjct: 383 VTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/168 (26%), Positives = 78/168 (46%), Gaps = 9/168 (5%)
Query: 750 HALSGHTGHILALYTWSGWMI-ASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVA 808
+ALSGH + + + + S S+D T++ WD R T G +V ++
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFER----TLKGHTDSVQDIS 157
Query: 809 VDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIK 868
D SG+LLA+ D + L+D +G +++ H H +V SV P ++++ S D IK
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217
Query: 869 VTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
+ ++Q + H++ V R + S S D+TV +W
Sbjct: 218 MWEVQTGYC----VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 68.2 bits (165), Expect = 3e-11
Identities = 62/279 (22%), Positives = 116/279 (41%), Gaps = 39/279 (13%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H+ + V + P ++ + S D +KV + T H +++D++F
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERT-----LKGHTDSVQDISF--- 158
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW-SGWMIASGSQDKTV 779
+ G +L S A D I D Q + + + GH ++ ++ +G I S S+DKT+
Sbjct: 159 -DHSGKLLASCSA-DMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTI 216
Query: 780 RFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 839
+ W+++ CV+ TF G V V + G L+A+ D + ++ +
Sbjct: 217 KMWEVQTGYCVK----TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAEL 272
Query: 840 HPHSSDVRSVRFSPGAHY--------------------LLTGSYDMKIKVTDLQGDLTKQ 879
H V + ++P + Y LL+GS D IK+ D+ +
Sbjct: 273 REHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC-- 330
Query: 880 LPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTY 918
+M + H + V +H+ LS + D+T+ +W Y
Sbjct: 331 --LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Score = 61.2 bits (147), Expect = 4e-09
Identities = 62/289 (21%), Positives = 112/289 (38%), Gaps = 58/289 (20%)
Query: 607 TQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIY 666
T +V+ ++F +G L A S T+++ + Q + H ++
Sbjct: 150 TDSVQDISFDHSGKLLASCSADMTIKLWDF-------------QGFECIRTMHGHDHNVS 196
Query: 667 CVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGA 726
VA P G + + S DK +K+ C T F+ H +R M P G
Sbjct: 197 SVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKT-----FTGHREWVR----MVRPNQDGT 247
Query: 727 ILISAGAGDCN----IYTTDCQRGQGLHALSGHTGHILALYTWS---------------- 766
++ S + T +C+ H H++ +W+
Sbjct: 248 LIASCSNDQTVRVWVVATKECKAELREHE------HVVECISWAPESSYSSISEATGSET 301
Query: 767 ------GWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQ 820
G + SGS+DKT++ WD+ C+ T G + V V G+ + +
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLM----TLVGHDNWVRGVLFHSGGKFILSCA 357
Query: 821 EDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKV 869
+D + ++D + R +++ + H V S+ F A Y++TGS D +KV
Sbjct: 358 DDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKV 406
Score = 45.4 bits (106), Expect = 2e-04
Identities = 55/237 (23%), Positives = 93/237 (39%), Gaps = 44/237 (18%)
Query: 570 SVIKPPLGDSPGSLSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSK 629
SV P GD S SR K + + + + + VR V + G L A SN +
Sbjct: 197 SVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQ 256
Query: 630 TLRVCAYPDVIDPSAHETPKQPVVRFKRNKHHKGSIYCVAWSP----------------- 672
T+RV K+ + ++H + C++W+P
Sbjct: 257 TVRVWVV----------ATKECKAELREHEH---VVECISWAPESSYSSISEATGSETKK 303
Query: 673 ---CGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILI 729
G L +GS DK +K+ + C T HD +R + F SGG ++
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMT-----LVGHDNWVRGVLF----HSGGKFIL 354
Query: 730 SAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTVRFWDLR 785
S A D + D + + + L+ H + +L + + + +GS D+TV+ W+ R
Sbjct: 355 SC-ADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 35.8 bits (81), Expect = 0.19
Identities = 26/80 (32%), Positives = 34/80 (42%), Gaps = 6/80 (7%)
Query: 842 HSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ-GDLTKQLPIMVVGEHKDKVIQCRWHTQ 900
H S V V F P +++ S D IKV D + GD + L H D V +
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLK-----GHTDSVQDISFDHS 161
Query: 901 DLSFLSSSADRTVTLWTYNG 920
S SAD T+ LW + G
Sbjct: 162 GKLLASCSADMTIKLWDFQG 181
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 69.7 bits (169), Expect = 1e-11
Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 17/215 (7%)
Query: 706 SMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHI--LALY 763
S H G +R +A G + G+ D I D G+ +L+GH + + +
Sbjct: 201 SGHLGWVRCIAVEPGNQ-----WFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
Query: 764 TWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDS 823
T S ++ + G +DK V+ WDL +R +HG SAV + + P+ +L T DS
Sbjct: 256 TRSPYLFSCG-EDKQVKCWDLEYNKVIR----HYHGHLSAVYGLDLHPTIDVLVTCSRDS 310
Query: 824 SCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIM 883
+ ++D+R V + H++ V +VR ++TGS+D I++ DL T+ +
Sbjct: 311 TARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTR----V 366
Query: 884 VVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLWTY 918
+ HK V H + +F S S D + W +
Sbjct: 367 TLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKF 400
Score = 37.4 bits (85), Expect = 0.065
Identities = 45/211 (21%), Positives = 75/211 (35%), Gaps = 40/211 (18%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAET----------------CNATGPDLE 704
H ++Y + P +L T S D ++ + C A P +
Sbjct: 287 HLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQII 346
Query: 705 FSMHDGTIRDLAFMEGP---------ESGGAILI-------SAGAGDCNIYTTDCQRGQG 748
HD TIR + G +S A+++ ++G+ D NI G
Sbjct: 347 TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSF 405
Query: 749 LHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVA 808
+ LSGH I L S ++ SG+ + T+ WD R G F +AV +
Sbjct: 406 IQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWR-------TGYNFQRVHAAVQPGS 458
Query: 809 VDPSGRLLATGQEDSSCMLYDIRGGRMVQSY 839
+D + A + S L + ++ Y
Sbjct: 459 LDSESGIFACAFDQSESRLLTAEADKTIKVY 489
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 69.3 bits (168), Expect = 2e-11
Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 13/165 (7%)
Query: 757 GHILALYTWS----GWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPS 812
GH + +Y + G + +G D R WDLR C+ + G + + P+
Sbjct: 363 GHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL----EGHLKEIYGINFSPN 418
Query: 813 GRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSP-GAHYLLTGSYDMKIKVTD 871
G +ATG D++C ++D+R R V + H + V V+F P ++LLTG+YD K+
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478
Query: 872 LQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
G P+ + H+ KV+ + + S DRT LW
Sbjct: 479 HPG----WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 66.2 bits (160), Expect = 1e-10
Identities = 49/195 (25%), Positives = 89/195 (45%), Gaps = 12/195 (6%)
Query: 729 ISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTW--SGWMIASGSQDKTVRFWDLRV 786
+++ A D ++ + + + GHT + A W SG + + D++ R WDL
Sbjct: 296 LASCAADGSVKLWSLDSDEPVADIEGHTVRV-ARVMWHPSGRFLGTTCYDRSWRLWDLEA 354
Query: 787 PSCVRVVGTTFHGTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDV 846
++ H G V +A G L TG D+ ++D+R GR + H ++
Sbjct: 355 QE--EILHQEGHSMG--VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 410
Query: 847 RSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLS 906
+ FSP +++ TGS D KV DL+ ++ + + H++ V ++ +FL
Sbjct: 411 YGINFSPNGYHIATGSGDNTCKVWDLR----QRRCVYTIPAHQNLVTGVKFEPIHGNFLL 466
Query: 907 SSA-DRTVTLWTYNG 920
+ A D T +WT+ G
Sbjct: 467 TGAYDNTAKIWTHPG 481
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/123 (30%), Positives = 52/123 (42%), Gaps = 10/123 (8%)
Query: 661 HKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEG 720
H IY + +SP G +ATGS D KV C T P H + + F
Sbjct: 406 HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIP-----AHQNLVTGVKF--E 458
Query: 721 PESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILAL-YTWSGWMIASGSQDKTV 779
P G +L A I+T L L+GH G ++ L + G +IA+ S D+T
Sbjct: 459 PIHGNFLLTGAYDNTAKIWTH--PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTF 516
Query: 780 RFW 782
+ W
Sbjct: 517 KLW 519
Score = 35.0 bits (79), Expect = 0.32
Identities = 29/111 (26%), Positives = 47/111 (42%), Gaps = 8/111 (7%)
Query: 769 MIASGSQDKTVRFWDLRVPSCVRVVGTTFHGT--GSAV----ASVAVDPSGRLLATGQED 822
M+A+ + W VP C + H T G+ V ++V++DP LA+ D
Sbjct: 245 MLATACWSGLCKLWS--VPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAAD 302
Query: 823 SSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQ 873
S L+ + V H+ V V + P +L T YD ++ DL+
Sbjct: 303 GSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLE 353
Score = 34.7 bits (78), Expect = 0.42
Identities = 24/114 (21%), Positives = 49/114 (42%), Gaps = 12/114 (10%)
Query: 811 PSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHY--------LLTGS 862
P+ ++LAT C L+ + ++ + H+++V ++ F P + L + +
Sbjct: 241 PNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCA 300
Query: 863 YDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVTLW 916
D +K+ L D P+ + H +V + WH ++ DR+ LW
Sbjct: 301 ADGSVKLWSLDSD----EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLW 350
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,306,226
Number of Sequences: 37866
Number of extensions: 1797782
Number of successful extensions: 9067
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 197
Number of HSP's that attempted gapping in prelim test: 6552
Number of HSP's gapped (non-prelim): 1587
length of query: 920
length of database: 18,247,518
effective HSP length: 112
effective length of query: 808
effective length of database: 14,006,526
effective search space: 11317273008
effective search space used: 11317273008
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.