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Search of human proteins with 21630285
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21630285 PDZ domain containing 3 [Homo sapiens]
(491 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21630285 PDZ domain containing 3 [Homo sapiens] 995 0.0
gi|21361142 PDZ domain containing 1 [Homo sapiens] 215 8e-56
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 131 2e-30
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 131 2e-30
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 120 2e-27
gi|45827729 scribble isoform b [Homo sapiens] 78 2e-14
gi|45827731 scribble isoform a [Homo sapiens] 78 2e-14
gi|112382257 InaD-like [Homo sapiens] 66 8e-11
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 65 1e-10
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 65 1e-10
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 61 3e-09
gi|41281808 harmonin isoform b3 [Homo sapiens] 60 3e-09
gi|71480164 harmonin isoform a [Homo sapiens] 60 3e-09
gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo... 60 3e-09
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 60 6e-09
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 60 6e-09
gi|148746189 multiple PDZ domain protein [Homo sapiens] 58 2e-08
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 57 3e-08
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 57 5e-08
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 57 5e-08
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 52 1e-06
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 52 1e-06
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 52 2e-06
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 52 2e-06
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 50 4e-06
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 50 6e-06
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 50 6e-06
gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 49 8e-06
gi|31742501 sorting nexin family member 27 [Homo sapiens] 49 8e-06
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 49 8e-06
>gi|21630285 PDZ domain containing 3 [Homo sapiens]
Length = 491
Score = 995 bits (2573), Expect = 0.0
Identities = 491/491 (100%), Positives = 491/491 (100%)
Query: 1 MEKAADLQDTASLTLKFKFNPKLGIDNPVLSLAEDHDPYDPWSLERPRFCLLSKEEGKSF 60
MEKAADLQDTASLTLKFKFNPKLGIDNPVLSLAEDHDPYDPWSLERPRFCLLSKEEGKSF
Sbjct: 1 MEKAADLQDTASLTLKFKFNPKLGIDNPVLSLAEDHDPYDPWSLERPRFCLLSKEEGKSF 60
Query: 61 GFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSP 120
GFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSP
Sbjct: 61 GFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSP 120
Query: 121 RVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFW 180
RVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFW
Sbjct: 121 RVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFW 180
Query: 181 LVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEG 240
LVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEG
Sbjct: 181 LVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEG 240
Query: 241 WALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAV 300
WALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAV
Sbjct: 241 WALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAV 300
Query: 301 AGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGS 360
AGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGS
Sbjct: 301 AGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGS 360
Query: 361 SSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGG 420
SSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGG
Sbjct: 361 SSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGG 420
Query: 421 SAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGA 480
SAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGA
Sbjct: 421 SAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGA 480
Query: 481 AEDWALASDLL 491
AEDWALASDLL
Sbjct: 481 AEDWALASDLL 491
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 215 bits (547), Expect = 8e-56
Identities = 147/429 (34%), Positives = 219/429 (51%), Gaps = 38/429 (8%)
Query: 47 PRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHE 106
PR C LSK+EG+++GF L+ E GH+V V+ + A++ GLQ+GDR+L +N V+ E
Sbjct: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
Query: 107 DYAVVVRRIRASSPRVLLTVLARHAHDVA---RAQLGE-----------DAHLCPTLGPG 152
++ VV +R S V L VL +++ A R L E D L P + G
Sbjct: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNGG 126
Query: 153 VR----PRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAERAGVPPGARLLEVNG- 205
V+ PRLC++VK+ G +GFS+ G +G + ++ G A RAGV L+EVNG
Sbjct: 127 VQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGE 186
Query: 206 -------------LWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHL 252
+ +SG +V L+ E +++ + + A LP +PR + +
Sbjct: 187 NVEDASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPHQPRIVEM 246
Query: 253 EKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEE 312
+KG G+GF LR + GQ + ++D G PA++AG++ D +VAV GESVE L H+
Sbjct: 247 KKGSNGYGFYLRAGSE---QKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDS 303
Query: 313 TVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVETEDPS 372
V I+ G SL VVD E D + + SP L+ ++ E P + A + + S
Sbjct: 304 VVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVS 363
Query: 373 LEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDV 432
+ V + C L G G YGF L+ + P FI +V GG A AGL+ DV
Sbjct: 364 SPPDTTEEVDHKPKLCRLAKGENG-YGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDV 422
Query: 433 ILEVNGYPV 441
I+EVNG V
Sbjct: 423 IIEVNGVNV 431
Score = 107 bits (267), Expect = 2e-23
Identities = 96/373 (25%), Positives = 159/373 (42%), Gaps = 54/373 (14%)
Query: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
+PR C L KE G S+GF L+ G+ G + + P A R G+ D ++ VN + VE
Sbjct: 132 QPRLCYLVKEGG-SYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVED 190
Query: 106 EDYAVVVRRIRASSPRVLLTVLARHA---HDVARAQLGEDAHLCPTLGPGVRPRLCHIVK 162
+ VV +++ S RV+ ++ + H + Q + L +PR+ + K
Sbjct: 191 ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPH--QPRIVEMKK 248
Query: 163 DEGGFGFSVTHGNQGPFWLV--LSTGGAAERAGVPPGARLLEVNG--------------L 206
G+GF + G++ ++ + +G AE AG+ ++ VNG +
Sbjct: 249 GSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHDSVVEMI 308
Query: 207 WQSGQQVTLLVAGPEVEEQCR---------------------------QLGLPLAAPLAE 239
+ G Q +LLV E + R L +++P
Sbjct: 309 RKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPDT 368
Query: 240 GWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVA 299
+ KP+ L KG G+GF L +GL PG F+ EV G PA AG++ D ++
Sbjct: 369 TEEVDHKPKLCRLAKGENGYGFHLNAIRGL---PGSFIKEVQKGGPADLAGLEDEDVIIE 425
Query: 300 VAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQG 359
V G +V +E+ V RIQ G V+L V +A +F ++ + L + +P
Sbjct: 426 VNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSL--ADPLDTPPD 483
Query: 360 SSSASLVETEDPS 372
S +VE+ S
Sbjct: 484 SKEGIVVESNHDS 496
Score = 79.7 bits (195), Expect = 5e-15
Identities = 59/200 (29%), Positives = 99/200 (49%), Gaps = 14/200 (7%)
Query: 257 QGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSR 316
Q +GF LR EK +G + V+ PA+KAG+Q GDR++ + G V+ H + V
Sbjct: 18 QNYGFFLRIEKDTEGH---LVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDL 74
Query: 317 IQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVETEDPSLEDT 376
++ G+ V+L V+D ++ R+ L+ QG S L + ++
Sbjct: 75 VRKSGNSVTLLVLDGDSYEKAVKTRVD----LKELGQSQKEQGLSDNILSPVMNGGVQTW 130
Query: 377 SVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEV 436
+ P R C+L GGSYGF L V ++++ +TP G A RAG+ D ++EV
Sbjct: 131 TQP------RLCYLVK-EGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEV 183
Query: 437 NGYPVGGQNDLERLQQLPEA 456
NG V + E ++++ ++
Sbjct: 184 NGENVEDASHEEVVEKVKKS 203
Score = 33.1 bits (74), Expect = 0.59
Identities = 20/63 (31%), Positives = 29/63 (46%)
Query: 386 RQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQN 445
R+C L G +YGF L + V A +AGLQ GD +L +NG V +
Sbjct: 8 RECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEE 67
Query: 446 DLE 448
++
Sbjct: 68 HMQ 70
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 131 bits (329), Expect = 2e-30
Identities = 97/264 (36%), Positives = 130/264 (49%), Gaps = 56/264 (21%)
Query: 153 VRPRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSG 210
+RPRLC +V+ E G+GF + G +G F + G AE A + G RL+EVNG+ G
Sbjct: 7 LRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
Query: 211 Q--------------QVTLLVAGPEVEEQCR-----------QLGLPLAAPLAE---GWA 242
+ Q LLV E +E+ R Q GLP A E WA
Sbjct: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
Query: 243 ------------------LPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGL 284
+PR HL KGPQG+GF L +K RPGQ++ VDPG
Sbjct: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKS---RPGQYIRSVDPGS 183
Query: 285 PAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSP 344
PA ++G++A DRL+ V G++VEGL H E V+ I+ + L VVDPE D F +R++P
Sbjct: 184 PAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
Query: 345 LLFLENTEAP-ASP--QGSSSASL 365
E+ E P SP G+S A L
Sbjct: 244 T--EEHVEGPLPSPVTNGTSPAQL 265
Score = 119 bits (298), Expect = 6e-27
Identities = 82/219 (37%), Positives = 108/219 (49%), Gaps = 9/219 (4%)
Query: 244 PTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGE 303
P +PR L +G QG+GF L EKG R GQF+ V+PG PA+ A ++AGDRLV V G
Sbjct: 6 PLRPRLCRLVRGEQGYGFHLHGEKG---RRGQFIRRVEPGSPAEAAALRAGDRLVEVNGV 62
Query: 304 SVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLS-----PLLFLENTEAPASPQ 358
+VEG H + V RI+ L VVD E D +L+ L P P+
Sbjct: 63 NVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPK 122
Query: 359 GSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTP 418
+ + + + +D S P L R C L GP G YGF L S P +I V P
Sbjct: 123 PDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQG-YGFNLHSDKSRPGQYIRSVDP 181
Query: 419 GGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457
G AAR+GL+ D ++EVNG V G E + + E
Sbjct: 182 GSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKARE 220
Score = 88.6 bits (218), Expect = 1e-17
Identities = 76/253 (30%), Positives = 110/253 (43%), Gaps = 59/253 (23%)
Query: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
RPR C L + E + +GFHL E GR G + RV+PG+ A+ L+ GDR++ VN VE
Sbjct: 8 RPRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
Query: 106 EDYAVVVRRIRASSPRVLLTVLARHAHDVAR----------AQLG--------------- 140
E + VV+RI+A + L V+ + + R AQ G
Sbjct: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
Query: 141 ------EDAHLCPTLGP--GVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLST--GGAAE 190
+A GP +RPRLCH+ K G+GF++ P + S G A
Sbjct: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAA 186
Query: 191 RAGVPPGARLLEVNGLWQSG--------------QQVTLLVAGPEVEEQCRQLGL----- 231
R+G+ RL+EVNG G + LLV PE +E ++L +
Sbjct: 187 RSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEE 246
Query: 232 ----PLAAPLAEG 240
PL +P+ G
Sbjct: 247 HVEGPLPSPVTNG 259
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 131 bits (329), Expect = 2e-30
Identities = 97/264 (36%), Positives = 130/264 (49%), Gaps = 56/264 (21%)
Query: 153 VRPRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSG 210
+RPRLC +V+ E G+GF + G +G F + G AE A + G RL+EVNG+ G
Sbjct: 7 LRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
Query: 211 Q--------------QVTLLVAGPEVEEQCR-----------QLGLPLAAPLAE---GWA 242
+ Q LLV E +E+ R Q GLP A E WA
Sbjct: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
Query: 243 ------------------LPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGL 284
+PR HL KGPQG+GF L +K RPGQ++ VDPG
Sbjct: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKS---RPGQYIRSVDPGS 183
Query: 285 PAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSP 344
PA ++G++A DRL+ V G++VEGL H E V+ I+ + L VVDPE D F +R++P
Sbjct: 184 PAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
Query: 345 LLFLENTEAP-ASP--QGSSSASL 365
E+ E P SP G+S A L
Sbjct: 244 T--EEHVEGPLPSPVTNGTSPAQL 265
Score = 119 bits (298), Expect = 6e-27
Identities = 82/219 (37%), Positives = 108/219 (49%), Gaps = 9/219 (4%)
Query: 244 PTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGE 303
P +PR L +G QG+GF L EKG R GQF+ V+PG PA+ A ++AGDRLV V G
Sbjct: 6 PLRPRLCRLVRGEQGYGFHLHGEKG---RRGQFIRRVEPGSPAEAAALRAGDRLVEVNGV 62
Query: 304 SVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLS-----PLLFLENTEAPASPQ 358
+VEG H + V RI+ L VVD E D +L+ L P P+
Sbjct: 63 NVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPK 122
Query: 359 GSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTP 418
+ + + + +D S P L R C L GP G YGF L S P +I V P
Sbjct: 123 PDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQG-YGFNLHSDKSRPGQYIRSVDP 181
Query: 419 GGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457
G AAR+GL+ D ++EVNG V G E + + E
Sbjct: 182 GSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKARE 220
Score = 88.6 bits (218), Expect = 1e-17
Identities = 76/253 (30%), Positives = 110/253 (43%), Gaps = 59/253 (23%)
Query: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
RPR C L + E + +GFHL E GR G + RV+PG+ A+ L+ GDR++ VN VE
Sbjct: 8 RPRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
Query: 106 EDYAVVVRRIRASSPRVLLTVLARHAHDVAR----------AQLG--------------- 140
E + VV+RI+A + L V+ + + R AQ G
Sbjct: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
Query: 141 ------EDAHLCPTLGP--GVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLST--GGAAE 190
+A GP +RPRLCH+ K G+GF++ P + S G A
Sbjct: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAA 186
Query: 191 RAGVPPGARLLEVNGLWQSG--------------QQVTLLVAGPEVEEQCRQLGL----- 231
R+G+ RL+EVNG G + LLV PE +E ++L +
Sbjct: 187 RSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEE 246
Query: 232 ----PLAAPLAEG 240
PL +P+ G
Sbjct: 247 HVEGPLPSPVTNG 259
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 120 bits (302), Expect = 2e-27
Identities = 83/203 (40%), Positives = 107/203 (52%), Gaps = 9/203 (4%)
Query: 247 PRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVE 306
PR LEKGP G+GF L EKG + GQ++ V+PG PA+KAG+ AGDRLV V GE+VE
Sbjct: 12 PRLCCLEKGPNGYGFHLHGEKG---KLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVE 68
Query: 307 GLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRL---SPLLFLENTEAPASPQGSSSA 363
H++ VSRI+ + V L VVDPE D + + LL + A P ++
Sbjct: 69 KETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEV 128
Query: 364 SLVETE-DPSLEDTSVPSV-PLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGS 421
E +P D S P L R C + GP G YGF L S P FI V P
Sbjct: 129 QGAGNENEPREADKSHPEQRELRPRLCTMKKGPSG-YGFNLHSDKSKPGQFIRSVDPDSP 187
Query: 422 AARAGLQVGDVILEVNGYPVGGQ 444
A +GL+ D I+EVNG + G+
Sbjct: 188 AEASGLRAQDRIVEVNGVCMEGK 210
Score = 113 bits (283), Expect = 3e-25
Identities = 84/239 (35%), Positives = 116/239 (48%), Gaps = 53/239 (22%)
Query: 155 PRLCHIVKDEGGFGFSVTHGNQGP---FWLVLSTGGAAERAGVPPGARLLEVNGL---WQ 208
PRLC + K G+GF + HG +G + ++ G AE+AG+ G RL+EVNG +
Sbjct: 12 PRLCCLEKGPNGYGFHL-HGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKE 70
Query: 209 SGQQVT-----------LLVAGPEVEEQCRQLGLP-----LAAPLAEGWALPT------- 245
+ QQV LLV PE +EQ ++LG+ L A A G A P
Sbjct: 71 THQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQG 130
Query: 246 --------------------KPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLP 285
+PR ++KGP G+GF L +K +PGQF+ VDP P
Sbjct: 131 AGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKS---KPGQFIRSVDPDSP 187
Query: 286 AKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSP 344
A+ +G++A DR+V V G +EG H + VS I+ G L VVD E D FF R+ P
Sbjct: 188 AEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIP 246
Score = 81.3 bits (199), Expect = 2e-15
Identities = 74/252 (29%), Positives = 104/252 (41%), Gaps = 59/252 (23%)
Query: 47 PRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHE 106
PR C L K +GFHL E G+ G + V+PG+ A++ GL GDR++ VN + VE E
Sbjct: 12 PRLCCLEKGPN-GYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKE 70
Query: 107 DYAVVVRRIRASSPRVLLTVL------------ARHAHDVARAQ----LGEDAHLCPTLG 150
+ VV RIRA+ V L V+ + ++ RAQ E G
Sbjct: 71 THQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPAAAEVQG 130
Query: 151 PG-----------------VRPRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAER 191
G +RPRLC + K G+GF++ G F + AE
Sbjct: 131 AGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEA 190
Query: 192 AGVPPGARLLEVNGLWQSGQQ--------------VTLLVAGPEVEE---QCR------Q 228
+G+ R++EVNG+ G+Q LLV E +E +CR
Sbjct: 191 SGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEH 250
Query: 229 LGLPLAAPLAEG 240
L PL P G
Sbjct: 251 LNGPLPVPFTNG 262
Score = 52.4 bits (124), Expect = 9e-07
Identities = 29/88 (32%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
RPR C + K +GF+L + + G + VDP + A+ GL+ DRI+ VN +E
Sbjct: 151 RPRLCTMKKGPS-GYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEG 209
Query: 106 EDYAVVVRRIRASSPRVLLTVLARHAHD 133
+ + VV IRA L V+ R +
Sbjct: 210 KQHGDVVSAIRAGGDETKLLVVDRETDE 237
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 77.8 bits (190), Expect = 2e-14
Identities = 104/370 (28%), Positives = 148/370 (40%), Gaps = 72/370 (19%)
Query: 160 IVKDEGGFGFSVTHG---------NQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSG 210
I++ GG G S+ G ++G F +S G A RAGV G +LLEVNG+ G
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790
Query: 211 QQ------------------------------VTLLVAGPEVEEQCRQ-----LGLPLAA 235
+ VT+ PE + R+ L LPL
Sbjct: 791 AEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLP 850
Query: 236 PLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLD----GRPGQFLWEVDPGLPAKKAG- 290
P + G CL + +G GF + KG G G F+ + G A +AG
Sbjct: 851 PESPGPLRQRHVACL--ARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGT 908
Query: 291 MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLEN 350
+Q GDR++++ G V H+ VS + ++L +++ EA + SPL
Sbjct: 909 LQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL-LLEREAG---GPLPPSPLPHSSP 964
Query: 351 TEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQC--FLYPGPGGSYGFRLSCVASG 408
A + ++A+ PSL + + + G P GG G LS V
Sbjct: 965 PTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLG--LSIVGGS 1022
Query: 409 -----------PRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457
P +FIS+V P G AAR+GL+VGD IL VNG V E + L
Sbjct: 1023 DHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL--LR 1080
Query: 458 PPLCLKLAAR 467
P L L L R
Sbjct: 1081 PCLELSLLVR 1090
Score = 65.9 bits (159), Expect = 8e-11
Identities = 116/469 (24%), Positives = 171/469 (36%), Gaps = 135/469 (28%)
Query: 72 GHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHA 131
G + RV A R G++ GD++L VN ++ ++ V +R + V + V
Sbjct: 757 GIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERM 816
Query: 132 HDVARAQL------------------GEDAHLCPTLGPG-VRPR-LCHIVKDEGGFGFSV 171
+ A G L P PG +R R + + + E G GFS+
Sbjct: 817 VEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSI 876
Query: 172 THG---------NQGPFWLVLSTGGAAERAG-VPPGARLLEVNGL----WQSGQQVTLLV 217
G + G F ++ GGAA RAG + G R+L +NG+ + V+LL
Sbjct: 877 AGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLT 936
Query: 218 AG--------------------------PEVEEQCRQL--------GLPLAAPLAEGWAL 243
A P + GLP AP AL
Sbjct: 937 AASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAAL 996
Query: 244 ----PTKPRCLHLEKGPQGFGFLLREEKGLD----GRPGQFLWEVDPGLPAKKAGMQAGD 295
P + L GP G + + PG F+ +V P A ++G++ GD
Sbjct: 997 EGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGD 1056
Query: 296 RLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPA 355
R++AV G+ V H+E VS + L P L L
Sbjct: 1057 RILAVNGQDVRDATHQEAVSAL------------------------LRPCLEL------- 1085
Query: 356 SPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASG----PR- 410
SL+ DP+ P G R+ + PG G + A G PR
Sbjct: 1086 --------SLLVRRDPA---------PPGLRELCIQKAPGERLGISIRGGARGHAGNPRD 1128
Query: 411 -----LFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQL 453
+FIS+V+P G+A R G L+VG +LEVN + G E +Q L
Sbjct: 1129 PTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Score = 57.8 bits (138), Expect = 2e-08
Identities = 96/351 (27%), Positives = 140/351 (39%), Gaps = 69/351 (19%)
Query: 38 PYDPWSL-ERPRFCLLSKEEGKSFGF-----HLQQELGRAGHVVCRVDPGTSAQRQG-LQ 90
P P L +R CL E G F G AG V R+ G +A R G LQ
Sbjct: 851 PESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQ 910
Query: 91 EGDRILAVNN-DVVE-HEDYAVVVRRIRASSPRVLLTVLARHAHD--------------- 133
GDR+L++N DV E D+AV + + A+SP + L +L R A
Sbjct: 911 VGDRVLSINGVDVTEARHDHAVSL--LTAASPTIAL-LLEREAGGPLPPSPLPHSSPPTA 967
Query: 134 -VARAQLGEDAHLCPTLGPGVRPRLC-------------HIVKDEGGFGFSVTHGNQ--- 176
VA + P L P + P L + + G G S+ G+
Sbjct: 968 AVATTSITTATPGVPGL-PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSS 1026
Query: 177 --------GPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQ 228
G F + G A R+G+ G R+L VNG Q + T A + C +
Sbjct: 1027 HPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNG--QDVRDATHQEAVSALLRPCLE 1084
Query: 229 LGLPLAAPLAEGWALPTKPRCLHLEKGP-QGFGFLLRE-EKGLDGRP------GQFLWEV 280
L L + A P R L ++K P + G +R +G G P G F+ +V
Sbjct: 1085 LSLLVRRDPA-----PPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 281 DP-GLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVD 330
P G + ++ G RL+ V +S+ GL H E V ++ G +++ V D
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCD 1190
Score = 48.1 bits (113), Expect = 2e-05
Identities = 71/243 (29%), Positives = 97/243 (39%), Gaps = 24/243 (9%)
Query: 10 TASLTLKFKFNPKLGIDNPVLSLAEDHDPYDPWSLERPR------FCLLSKEEGKSFGFH 63
T S+T P L P L A PY + PR ++ + S F
Sbjct: 971 TTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFG 1030
Query: 64 LQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVL 123
+Q+ G + +V P A R GL+ GDRILAVN V + V + P +
Sbjct: 1031 VQEP----GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL--LRPCLE 1084
Query: 124 LTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVL 183
L++L R D A L E LC PG R + G G ++G F +
Sbjct: 1085 LSLLVR--RDPAPPGLRE---LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 184 STGGAAERAG-VPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWA 242
S GAA R G + G RLLEVN QQ L + E + R +G L + +G+
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVN------QQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFE 1193
Query: 243 LPT 245
T
Sbjct: 1194 AST 1196
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 77.8 bits (190), Expect = 2e-14
Identities = 104/370 (28%), Positives = 148/370 (40%), Gaps = 72/370 (19%)
Query: 160 IVKDEGGFGFSVTHG---------NQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSG 210
I++ GG G S+ G ++G F +S G A RAGV G +LLEVNG+ G
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790
Query: 211 QQ------------------------------VTLLVAGPEVEEQCRQ-----LGLPLAA 235
+ VT+ PE + R+ L LPL
Sbjct: 791 AEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLP 850
Query: 236 PLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLD----GRPGQFLWEVDPGLPAKKAG- 290
P + G CL + +G GF + KG G G F+ + G A +AG
Sbjct: 851 PESPGPLRQRHVACL--ARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGT 908
Query: 291 MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLEN 350
+Q GDR++++ G V H+ VS + ++L +++ EA + SPL
Sbjct: 909 LQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL-LLEREAG---GPLPPSPLPHSSP 964
Query: 351 TEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQC--FLYPGPGGSYGFRLSCVASG 408
A + ++A+ PSL + + + G P GG G LS V
Sbjct: 965 PTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLG--LSIVGGS 1022
Query: 409 -----------PRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457
P +FIS+V P G AAR+GL+VGD IL VNG V E + L
Sbjct: 1023 DHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL--LR 1080
Query: 458 PPLCLKLAAR 467
P L L L R
Sbjct: 1081 PCLELSLLVR 1090
Score = 65.9 bits (159), Expect = 8e-11
Identities = 116/469 (24%), Positives = 171/469 (36%), Gaps = 135/469 (28%)
Query: 72 GHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHA 131
G + RV A R G++ GD++L VN ++ ++ V +R + V + V
Sbjct: 757 GIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERM 816
Query: 132 HDVARAQL------------------GEDAHLCPTLGPG-VRPR-LCHIVKDEGGFGFSV 171
+ A G L P PG +R R + + + E G GFS+
Sbjct: 817 VEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSI 876
Query: 172 THG---------NQGPFWLVLSTGGAAERAG-VPPGARLLEVNGL----WQSGQQVTLLV 217
G + G F ++ GGAA RAG + G R+L +NG+ + V+LL
Sbjct: 877 AGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLT 936
Query: 218 AG--------------------------PEVEEQCRQL--------GLPLAAPLAEGWAL 243
A P + GLP AP AL
Sbjct: 937 AASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAAL 996
Query: 244 ----PTKPRCLHLEKGPQGFGFLLREEKGLD----GRPGQFLWEVDPGLPAKKAGMQAGD 295
P + L GP G + + PG F+ +V P A ++G++ GD
Sbjct: 997 EGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGD 1056
Query: 296 RLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPA 355
R++AV G+ V H+E VS + L P L L
Sbjct: 1057 RILAVNGQDVRDATHQEAVSAL------------------------LRPCLEL------- 1085
Query: 356 SPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASG----PR- 410
SL+ DP+ P G R+ + PG G + A G PR
Sbjct: 1086 --------SLLVRRDPA---------PPGLRELCIQKAPGERLGISIRGGARGHAGNPRD 1128
Query: 411 -----LFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQL 453
+FIS+V+P G+A R G L+VG +LEVN + G E +Q L
Sbjct: 1129 PTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Score = 57.8 bits (138), Expect = 2e-08
Identities = 96/351 (27%), Positives = 140/351 (39%), Gaps = 69/351 (19%)
Query: 38 PYDPWSL-ERPRFCLLSKEEGKSFGF-----HLQQELGRAGHVVCRVDPGTSAQRQG-LQ 90
P P L +R CL E G F G AG V R+ G +A R G LQ
Sbjct: 851 PESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQ 910
Query: 91 EGDRILAVNN-DVVE-HEDYAVVVRRIRASSPRVLLTVLARHAHD--------------- 133
GDR+L++N DV E D+AV + + A+SP + L +L R A
Sbjct: 911 VGDRVLSINGVDVTEARHDHAVSL--LTAASPTIAL-LLEREAGGPLPPSPLPHSSPPTA 967
Query: 134 -VARAQLGEDAHLCPTLGPGVRPRLC-------------HIVKDEGGFGFSVTHGNQ--- 176
VA + P L P + P L + + G G S+ G+
Sbjct: 968 AVATTSITTATPGVPGL-PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSS 1026
Query: 177 --------GPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQ 228
G F + G A R+G+ G R+L VNG Q + T A + C +
Sbjct: 1027 HPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNG--QDVRDATHQEAVSALLRPCLE 1084
Query: 229 LGLPLAAPLAEGWALPTKPRCLHLEKGP-QGFGFLLRE-EKGLDGRP------GQFLWEV 280
L L + A P R L ++K P + G +R +G G P G F+ +V
Sbjct: 1085 LSLLVRRDPA-----PPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 281 DP-GLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVD 330
P G + ++ G RL+ V +S+ GL H E V ++ G +++ V D
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCD 1190
Score = 48.1 bits (113), Expect = 2e-05
Identities = 71/243 (29%), Positives = 97/243 (39%), Gaps = 24/243 (9%)
Query: 10 TASLTLKFKFNPKLGIDNPVLSLAEDHDPYDPWSLERPR------FCLLSKEEGKSFGFH 63
T S+T P L P L A PY + PR ++ + S F
Sbjct: 971 TTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFG 1030
Query: 64 LQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVL 123
+Q+ G + +V P A R GL+ GDRILAVN V + V + P +
Sbjct: 1031 VQEP----GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSAL--LRPCLE 1084
Query: 124 LTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVL 183
L++L R D A L E LC PG R + G G ++G F +
Sbjct: 1085 LSLLVR--RDPAPPGLRE---LCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKV 1139
Query: 184 STGGAAERAG-VPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWA 242
S GAA R G + G RLLEVN QQ L + E + R +G L + +G+
Sbjct: 1140 SPTGAAGRDGRLRVGLRLLEVN------QQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFE 1193
Query: 243 LPT 245
T
Sbjct: 1194 AST 1196
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 65.9 bits (159), Expect = 8e-11
Identities = 132/548 (24%), Positives = 199/548 (36%), Gaps = 114/548 (20%)
Query: 17 FKFNPKLGID--NPVLSLAEDHDPYDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHV 74
F + PKLG + N V+ + +ERP L G S Q LG+
Sbjct: 108 FPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGL----GFSVVALRSQNLGKVDIF 163
Query: 75 VCRVDPGTSAQR-QGLQEGDRILAVNNDVVEH---EDYAVVVRRIRASSPRVLLTVLARH 130
V V PG+ A R Q L+E D+ILA+N+ ++ A+ + + S R+++ H
Sbjct: 164 VKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH 223
Query: 131 AHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHG-NQGPFWLVLSTGGAA 189
+ L D L T+ G ++ D G GF + G G + GG A
Sbjct: 224 TKSSTSSSL-NDTTLPETVCWG-HVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLA 281
Query: 190 ERAG-VPPGARLLEVNG--------------LWQSGQQVTLLVAGPEVEEQCRQLGLPLA 234
+R G + G +L++ G L G V +LVA + + +
Sbjct: 282 DRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVA----RDPAGDISVTPP 337
Query: 235 APLAEGWALPTKPRCLHLEKGPQGFGFLLR----EEKGLDGR------------------ 272
AP A ALPT KGP L E DG+
Sbjct: 338 APAALPVALPTV-----ASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA 392
Query: 273 PGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVV-- 329
G ++ + PG A G +Q D++VAV G +++G + + V ++ G V LT+V
Sbjct: 393 SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRR 452
Query: 330 ---------DPEADRFFSMVRLS-PLLFL--------------------------ENTEA 353
+P +DR + L P LFL +N +A
Sbjct: 453 KTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQA 512
Query: 354 -------PASPQGSSSASLVETEDPSLE------DTSVPSVPLGSRQCFLYPGPGGSYGF 400
P SP+ + P E DT + + L P G
Sbjct: 513 LEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGV 572
Query: 401 RLSCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQLPEAEPP 459
+ + +IS + GG G LQ D +LEVNG + G++ E + L E PP
Sbjct: 573 EVD--SFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP 630
Query: 460 LCLKLAAR 467
L R
Sbjct: 631 FTLVCCRR 638
Score = 45.8 bits (107), Expect = 9e-05
Identities = 81/352 (23%), Positives = 141/352 (40%), Gaps = 30/352 (8%)
Query: 136 RAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVL-----STGGAAE 190
+A L D CP + PG + + I K G G S+ G P ++ G AA
Sbjct: 1418 QAPLSVDPATCPIV-PG-QEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAAR 1475
Query: 191 RAGVPPGARLLEVNGL-WQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRC 249
+ G ++LEVNG+ ++ + A + ++ R + A + L P
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVD 1535
Query: 250 LHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGL 308
L +K +G G + G G F+ ++ G A G + GD++++V GE +
Sbjct: 1536 LQ-KKAGRGLGLSI---VGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
Query: 309 GHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPAS------PQGSSS 362
E + ++ V L + A + S S A +S P +
Sbjct: 1592 SQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGL 1651
Query: 363 ASLVETE---DPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGP----RLFISQ 415
+LV T+ DPS +++ P R + + G ++ P +FI+
Sbjct: 1652 QNLVGTKRVSDPSQKNSGTDMEP---RTVEINRELSDALGISIAGGRGSPLGDIPVFIAM 1708
Query: 416 VTPGGSAARA-GLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAA 466
+ G AAR L+VGD I+ +NG P+ G + + + L A + L++ A
Sbjct: 1709 IQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
Score = 33.9 bits (76), Expect = 0.35
Identities = 45/200 (22%), Positives = 79/200 (39%), Gaps = 29/200 (14%)
Query: 274 GQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTV---- 328
G F+ +V PA K ++ GD+++ V+G ++ H E V I+ G+ V V
Sbjct: 1101 GIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLS 1160
Query: 329 --------VDPEADRFFSMVRLSPLLFLENTEAPASPQ---GSSSASLVETEDPSLEDTS 377
V +A++ E + A P +L + D + E+ +
Sbjct: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDA 1220
Query: 378 VPSVPLGSRQCFLYPG-------PGGSYGFRLSCVASGPR----LFISQVTPGGSAARAG 426
+ R L PG G LS + R +F+ + P G AA G
Sbjct: 1221 FTDQKIRQRYADL-PGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADG 1279
Query: 427 -LQVGDVILEVNGYPVGGQN 445
+++GD +LE+N + G++
Sbjct: 1280 RMRIGDELLEINNQILYGRS 1299
Score = 30.4 bits (67), Expect = 3.8
Identities = 35/119 (29%), Positives = 50/119 (42%), Gaps = 14/119 (11%)
Query: 340 VRLSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYG 399
+ L+P +T+A + G A L S++ + P VP Q + G G
Sbjct: 1396 IPLAPASSYHSTDADFTGYGGFQAPL------SVDPATCPIVP---GQEMIIEISKGRSG 1446
Query: 400 FRLSCVASGPR----LFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQL 453
LS V + I +V G+AAR G L GD ILEVNG + + E + L
Sbjct: 1447 LGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Score = 30.4 bits (67), Expect = 3.8
Identities = 34/131 (25%), Positives = 55/131 (41%), Gaps = 18/131 (13%)
Query: 79 DPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQ 138
+ G +A+ L GD+IL VN + + + + +R + +V L V AH +
Sbjct: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAH----YR 1524
Query: 139 LGEDAHLCPTLGPGVRPRLCHIVKDEG-GFGFSVT--HGNQGPFWLVLSTGGAAERAG-V 194
E+ + P + K G G G S+ G F + GGAA+ G +
Sbjct: 1525 DEENLEIFPV----------DLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRL 1574
Query: 195 PPGARLLEVNG 205
G ++L VNG
Sbjct: 1575 IQGDQILSVNG 1585
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 65.5 bits (158), Expect = 1e-10
Identities = 79/297 (26%), Positives = 122/297 (41%), Gaps = 30/297 (10%)
Query: 162 KDEGGFGFSVTHGNQGP--------FWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQV 213
+ G GFS+ G P F + TGGAA + G L VN +V
Sbjct: 229 RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG------RLRVNDCILRVNEV 282
Query: 214 TLL-VAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGR 272
+ V + E ++ G + + + K + L KGP+G GF + G
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHI 342
Query: 273 PGQ---FLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTV 328
PG ++ ++ G A K G +Q GD+L+AV +E + HEE V+ ++ V L V
Sbjct: 343 PGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Query: 329 VDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGS--- 385
P + + +P ++ P S S+ L +T + V LG
Sbjct: 403 AKPTS--MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEI 460
Query: 386 ----RQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVN 437
R+ L+ G G GF + G +FIS + GG A +G L+ GD I+ VN
Sbjct: 461 TREPRKVVLHRGSTG-LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVN 516
Score = 37.0 bits (84), Expect = 0.041
Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 246 KPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGES 304
+PR + L +G G GF + G DG G F+ + G PA +G ++ GDR+++V
Sbjct: 463 EPRKVVLHRGSTGLGFNI--VGGEDGE-GIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 305 VEGLGHEETVSRIQGQGSCVSL 326
+ HE+ + ++ G V++
Sbjct: 520 LRAASHEQAAAALKNAGQAVTI 541
Score = 32.0 bits (71), Expect = 1.3
Identities = 40/169 (23%), Positives = 69/169 (40%), Gaps = 37/169 (21%)
Query: 75 VCRVDPGTSAQRQG-LQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTV---LARH 130
V ++ G +A + G LQ GD++LAVNN +E + V ++ +S V L V + +
Sbjct: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMY 409
Query: 131 AHD-------VARAQLGEDAHLCPTLGPGV-----------------------RPRLCHI 160
+D + D H+ P+ G PR +
Sbjct: 410 MNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVL 469
Query: 161 VKDEGGFGFSVTHG--NQGPFWLVLSTGGAAERAG-VPPGARLLEVNGL 206
+ G GF++ G +G F + GG A+ +G + G R++ VN +
Sbjct: 470 HRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSV 518
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 65.5 bits (158), Expect = 1e-10
Identities = 79/297 (26%), Positives = 122/297 (41%), Gaps = 30/297 (10%)
Query: 162 KDEGGFGFSVTHGNQGP--------FWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQV 213
+ G GFS+ G P F + TGGAA + G L VN +V
Sbjct: 229 RGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG------RLRVNDCILRVNEV 282
Query: 214 TLL-VAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGR 272
+ V + E ++ G + + + K + L KGP+G GF + G
Sbjct: 283 DVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHI 342
Query: 273 PGQ---FLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTV 328
PG ++ ++ G A K G +Q GD+L+AV +E + HEE V+ ++ V L V
Sbjct: 343 PGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402
Query: 329 VDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGS--- 385
P + + +P ++ P S S+ L +T + V LG
Sbjct: 403 AKPTS--MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEI 460
Query: 386 ----RQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVN 437
R+ L+ G G GF + G +FIS + GG A +G L+ GD I+ VN
Sbjct: 461 TREPRKVVLHRGSTG-LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVN 516
Score = 37.0 bits (84), Expect = 0.041
Identities = 24/82 (29%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 246 KPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGES 304
+PR + L +G G GF + G DG G F+ + G PA +G ++ GDR+++V
Sbjct: 463 EPRKVVLHRGSTGLGFNI--VGGEDGE-GIFISFILAGGPADLSGELRKGDRIISVNSVD 519
Query: 305 VEGLGHEETVSRIQGQGSCVSL 326
+ HE+ + ++ G V++
Sbjct: 520 LRAASHEQAAAALKNAGQAVTI 541
Score = 32.0 bits (71), Expect = 1.3
Identities = 40/169 (23%), Positives = 69/169 (40%), Gaps = 37/169 (21%)
Query: 75 VCRVDPGTSAQRQG-LQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTV---LARH 130
V ++ G +A + G LQ GD++LAVNN +E + V ++ +S V L V + +
Sbjct: 350 VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMY 409
Query: 131 AHD-------VARAQLGEDAHLCPTLGPGV-----------------------RPRLCHI 160
+D + D H+ P+ G PR +
Sbjct: 410 MNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVL 469
Query: 161 VKDEGGFGFSVTHG--NQGPFWLVLSTGGAAERAG-VPPGARLLEVNGL 206
+ G GF++ G +G F + GG A+ +G + G R++ VN +
Sbjct: 470 HRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSV 518
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 60.8 bits (146), Expect = 3e-09
Identities = 86/316 (27%), Positives = 129/316 (40%), Gaps = 53/316 (16%)
Query: 162 KDEGGFGFSVTHGNQGP--------FWLVLSTGGAAE---RAGVPP---GARLLEVNGLW 207
+ G GFS+ G P F + GGAA R GV ++V+ +
Sbjct: 136 RGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVV 195
Query: 208 QSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEK 267
S L AGP V R+ P P ++L KGP+G GF +
Sbjct: 196 HSRAVEALKEAGPVVRLVVRRRQPP-----------PETIMEVNLLKGPKGLGFSIAGGI 244
Query: 268 GLDGRPGQ---FLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSC 323
G PG ++ ++ G A+K G +Q GDRL+AV +++ + HEE V+ ++
Sbjct: 245 GNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDM 304
Query: 324 VSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASL-----VETE-----DPSL 373
V L V P + M +P + A A S ++SL VE++ P +
Sbjct: 305 VYLKVAKPGSLHLNDM--YAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQV 362
Query: 374 EDTSVPSVP----------LGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAA 423
T +P R+ L+ G G GF + G +F+S + GG A
Sbjct: 363 PPTRYSPIPRHMLAEEDFTREPRKIILHKGSTG-LGFNIVGGEDGEGIFVSFILAGGPAD 421
Query: 424 RAG-LQVGDVILEVNG 438
+G L+ GD IL VNG
Sbjct: 422 LSGELRRGDRILSVNG 437
Score = 41.6 bits (96), Expect = 0.002
Identities = 51/185 (27%), Positives = 83/185 (44%), Gaps = 10/185 (5%)
Query: 246 KPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGES 304
+PR + L KG G GF + G DG G F+ + G PA +G ++ GDR+++V G +
Sbjct: 383 EPRKIILHKGSTGLGFNI--VGGEDGE-GIFVSFILAGGPADLSGELRRGDRILSVNGVN 439
Query: 305 VEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSAS 364
+ HE+ + ++ G S+T+V +S R + + S S S S
Sbjct: 440 LRNATHEQAAAALKRAGQ--SVTIVAQYRPEEYS--RFESKIHDLREQMMNSSMSSGSGS 495
Query: 365 LVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCV-ASGPRLFISQ-VTPGGSA 422
L +E SL ++ C G SYG L + AS + ++ VTP G +
Sbjct: 496 LRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGES 555
Query: 423 ARAGL 427
+ G+
Sbjct: 556 EQIGV 560
Score = 36.2 bits (82), Expect = 0.070
Identities = 61/241 (25%), Positives = 95/241 (39%), Gaps = 73/241 (30%)
Query: 58 KSFGFHLQQELGRAGHV-------VCRVDPGTSAQRQG-LQEGDRILAVNNDVVEHEDYA 109
K GF + +G H+ + ++ G +AQ+ G LQ GDR+LAVNN ++ +
Sbjct: 234 KGLGFSIAGGIGNQ-HIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHE 292
Query: 110 VVVRRIRASSPRVLL-----------------------TVLARH--AHDVARAQLG---- 140
V ++ +S V L T LA + +H+ + LG
Sbjct: 293 EAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVES 352
Query: 141 EDAHLCPTLGPGVR-----------------PRLCHIVKDEGGFGFSVTHG--NQGPFWL 181
+ ++ P P R PR + K G GF++ G +G F
Sbjct: 353 KVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVS 412
Query: 182 VLSTGGAAERAG-VPPGARLLEVNG--------------LWQSGQQVTLLVAGPEVEEQC 226
+ GG A+ +G + G R+L VNG L ++GQ VT +VA EE
Sbjct: 413 FILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVT-IVAQYRPEEYS 471
Query: 227 R 227
R
Sbjct: 472 R 472
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 60.5 bits (145), Expect = 3e-09
Identities = 63/223 (28%), Positives = 99/223 (44%), Gaps = 27/223 (12%)
Query: 256 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVS 315
P+G G +R GL+ G F+ + G A G+Q GD +V + G S+ HEE ++
Sbjct: 95 PEGLGLSVRG--GLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVIN 152
Query: 316 RIQGQGSCVSLTVVDPEADRFFSM--VRLSP--LLFLENTEAPASPQGSSSASLVETEDP 371
I+ + + VS+ V R + V+ SP L + + S G SL +
Sbjct: 153 LIRTKKT-VSIKV------RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNR 205
Query: 372 SLEDTSVPSVPLGSRQ--CFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQV 429
++ V +GSR C + GP P +FIS V PG +A GL++
Sbjct: 206 ENKEKKVFISLVGSRGLGCSISSGP-----------IQKPGIFISHVKPGSLSAEVGLEI 254
Query: 430 GDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGL 472
GD I+EVNG + E + L ++ L + + A + R L
Sbjct: 255 GDQIVEVNGVDFSNLDHKEAVNVL-KSSRSLTISIVAAAGREL 296
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 60.5 bits (145), Expect = 3e-09
Identities = 63/223 (28%), Positives = 99/223 (44%), Gaps = 27/223 (12%)
Query: 256 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVS 315
P+G G +R GL+ G F+ + G A G+Q GD +V + G S+ HEE ++
Sbjct: 95 PEGLGLSVRG--GLEFGCGLFISHLIKGGQADSVGLQVGDEIVRINGYSISSCTHEEVIN 152
Query: 316 RIQGQGSCVSLTVVDPEADRFFSM--VRLSP--LLFLENTEAPASPQGSSSASLVETEDP 371
I+ + + VS+ V R + V+ SP L + + S G SL +
Sbjct: 153 LIRTKKT-VSIKV------RHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLGSPGNR 205
Query: 372 SLEDTSVPSVPLGSRQ--CFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQV 429
++ V +GSR C + GP P +FIS V PG +A GL++
Sbjct: 206 ENKEKKVFISLVGSRGLGCSISSGP-----------IQKPGIFISHVKPGSLSAEVGLEI 254
Query: 430 GDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGL 472
GD I+EVNG + E + L ++ L + + A + R L
Sbjct: 255 GDQIVEVNGVDFSNLDHKEAVNVL-KSSRSLTISIVAAAGREL 296
>gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo
sapiens]
Length = 227
Score = 60.5 bits (145), Expect = 3e-09
Identities = 42/127 (33%), Positives = 63/127 (49%), Gaps = 5/127 (3%)
Query: 246 KPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESV 305
KP+ L KG G+GF L +GL PG F+ EV G PA AG++ D ++ V G +V
Sbjct: 54 KPKLCRLAKGENGYGFHLNAIRGL---PGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNV 110
Query: 306 EGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASL 365
+E+ V RIQ G V+L V +A +F ++ + L + +P S +
Sbjct: 111 LDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSL--ADPLDTPPDSKEGIV 168
Query: 366 VETEDPS 372
VE+ S
Sbjct: 169 VESNHDS 175
Score = 55.1 bits (131), Expect = 1e-07
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 1/93 (1%)
Query: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
+P+ C L+K E +GFHL G G + V G A GL++ D I+ VN V
Sbjct: 54 KPKLCRLAKGEN-GYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLD 112
Query: 106 EDYAVVVRRIRASSPRVLLTVLARHAHDVARAQ 138
E Y VV RI++S V L V + A+D +A+
Sbjct: 113 EPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAK 145
Score = 50.4 bits (119), Expect = 4e-06
Identities = 37/110 (33%), Positives = 51/110 (46%), Gaps = 15/110 (13%)
Query: 339 MVRLSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQ-------CFLY 391
+ SP L+ ++ E P + S+ E P+ V S P + + C L
Sbjct: 9 LAHFSPFLYYQSQELP-------NGSVKEAPAPTPTSLEVSSPPDTTEEEDHKPKLCRLA 61
Query: 392 PGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPV 441
G G YGF L+ + P FI +V GG A AGL+ DVI+EVNG V
Sbjct: 62 KGENG-YGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNV 110
Score = 50.1 bits (118), Expect = 5e-06
Identities = 31/102 (30%), Positives = 50/102 (49%), Gaps = 16/102 (15%)
Query: 154 RPRLCHIVKDEGGFGFSVT--HGNQGPFWLVLSTGGAAERAGVPPGARLLEVNG------ 205
+P+LC + K E G+GF + G G F + GG A+ AG+ ++EVNG
Sbjct: 54 KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDE 113
Query: 206 --------LWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAE 239
+ SG+ VTLLV G + + + +P+ + LA+
Sbjct: 114 PYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLAD 155
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 59.7 bits (143), Expect = 6e-09
Identities = 80/309 (25%), Positives = 125/309 (40%), Gaps = 46/309 (14%)
Query: 162 KDEGGFGFSVTHGNQGP--------FWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQV 213
+ G GFS+ G P F + GGAA + G L VN +V
Sbjct: 113 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDG------RLRVNDSILFVNEV 166
Query: 214 TLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRC-----LHLEKGPQGFGFLLREEKG 268
+ EV L A + + + KP + L KGP+G GF + G
Sbjct: 167 DVR----EVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVG 222
Query: 269 LDGRPGQ---FLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCV 324
PG ++ ++ G A K G +Q GD+++AV +E + HE+ V+ ++ V
Sbjct: 223 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282
Query: 325 SLTVVDPE----ADRFFSM-VRLSPLLFLENTEAPASPQGSSSASLVETEDPS------- 372
L V P +D + + S L+N + +S G+ + + P
Sbjct: 283 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 342
Query: 373 --LEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAG-LQV 429
L + +P P R+ ++ G G GF + G +FIS + GG A +G L+
Sbjct: 343 DLLGEEDIPREP---RRIVIHRGSTG-LGFNIVGGEDGEGIFISFILAGGPADLSGELRK 398
Query: 430 GDVILEVNG 438
GD IL VNG
Sbjct: 399 GDQILSVNG 407
Score = 39.7 bits (91), Expect = 0.006
Identities = 27/96 (28%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 232 PLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG- 290
P+A L +P +PR + + +G G GF + G DG G F+ + G PA +G
Sbjct: 339 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNI--VGGEDGE-GIFISFILAGGPADLSGE 395
Query: 291 MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSL 326
++ GD++++V G + HE+ ++ G V++
Sbjct: 396 LRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 59.7 bits (143), Expect = 6e-09
Identities = 80/309 (25%), Positives = 125/309 (40%), Gaps = 46/309 (14%)
Query: 162 KDEGGFGFSVTHGNQGP--------FWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQV 213
+ G GFS+ G P F + GGAA + G L VN +V
Sbjct: 67 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDG------RLRVNDSILFVNEV 120
Query: 214 TLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRC-----LHLEKGPQGFGFLLREEKG 268
+ EV L A + + + KP + L KGP+G GF + G
Sbjct: 121 DVR----EVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVG 176
Query: 269 LDGRPGQ---FLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCV 324
PG ++ ++ G A K G +Q GD+++AV +E + HE+ V+ ++ V
Sbjct: 177 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 236
Query: 325 SLTVVDPE----ADRFFSM-VRLSPLLFLENTEAPASPQGSSSASLVETEDPS------- 372
L V P +D + + S L+N + +S G+ + + P
Sbjct: 237 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 296
Query: 373 --LEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAG-LQV 429
L + +P P R+ ++ G G GF + G +FIS + GG A +G L+
Sbjct: 297 DLLGEEDIPREP---RRIVIHRGSTG-LGFNIVGGEDGEGIFISFILAGGPADLSGELRK 352
Query: 430 GDVILEVNG 438
GD IL VNG
Sbjct: 353 GDQILSVNG 361
Score = 39.7 bits (91), Expect = 0.006
Identities = 27/96 (28%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 232 PLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG- 290
P+A L +P +PR + + +G G GF + G DG G F+ + G PA +G
Sbjct: 293 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNI--VGGEDGE-GIFISFILAGGPADLSGE 349
Query: 291 MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSL 326
++ GD++++V G + HE+ ++ G V++
Sbjct: 350 LRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 57.8 bits (138), Expect = 2e-08
Identities = 109/487 (22%), Positives = 189/487 (38%), Gaps = 107/487 (21%)
Query: 69 GRAGHVVCRVDPGTSAQRQG-LQEGDRILAVNNDVVE----HEDYAVVVRRI-------- 115
G G V + G+ A R G L+E D+ILA+N ++ H+ ++++
Sbjct: 161 GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVI 220
Query: 116 -RASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHG 174
R S P+++ +++R + AH P + +V D G GF + G
Sbjct: 221 ARGSLPQLVSPIVSRSPSAASTIS----AHSNPVHWQHMET--IELVNDGSGLGFGIIGG 274
Query: 175 NQ-GPFWLVLSTGGAAERAG-VPPGARLLEVNG--------------LWQSGQQVTLLVA 218
G + GG A++ G + G +L++ L Q G +V L++A
Sbjct: 275 KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIA 334
Query: 219 GPEVEEQCRQLGLPLAAPLAEGWALPTKPRC--------------------LHLEKGPQG 258
+EE+ AP A G L + P + L K QG
Sbjct: 335 RGAIEER--------TAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQG 386
Query: 259 FGFLLRE---EKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETV 314
G + +K L+ G F+ + + G +Q GD+++AV G +++G +++ V
Sbjct: 387 LGITIAGYIGDKKLEPS-GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAV 445
Query: 315 SRIQGQGSCVSLTVV--------------DPEADRFFSMVRLSPLL--------FLENTE 352
++ G V LT++ D D S V S + FL +T
Sbjct: 446 EVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTR 505
Query: 353 ----APASPQGSS--SASLVETEDPSLEDTSVPS-----VPLGSRQCFLYPGP-GGSYGF 400
P +G SA + E ED ++ ++ + + + + + G
Sbjct: 506 NTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGL 565
Query: 401 RLSCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQND---LERLQQLPEA 456
+S A+ FI V P G +G L GD +LEVNG + G+N + L++LP
Sbjct: 566 GISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE 625
Query: 457 EPPLCLK 463
+C +
Sbjct: 626 VTMVCCR 632
Score = 50.1 bits (118), Expect = 5e-06
Identities = 96/391 (24%), Positives = 157/391 (40%), Gaps = 59/391 (15%)
Query: 79 DPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQ 138
+ G + + L GD+IL VN + + + +R + RV LT+ A
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPY----- 1715
Query: 139 LGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVT--HGNQGPFWLVLSTGGAAERAG-VP 195
++ +C TL ++ K G G S+ + G F + GG A+ G +
Sbjct: 1716 --KEEEVCDTLTIELQK------KPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLM 1767
Query: 196 PGARLLEVNGLWQSGQQVTLLVAGPEVEE-QCRQLGLPLA-APLAEGWALPTKP------ 247
G ++L VNG + A +V E PL+ + +E +K
Sbjct: 1768 QGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASE 1827
Query: 248 ----RCLHLEKGP-QGFGFLLREEKGLD-GRPGQFLWEVDP-GLPAKKAGMQAGDRLVAV 300
R + ++KGP G + G G F+ + P G+ A+ ++ GDR+V +
Sbjct: 1828 IQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTI 1887
Query: 301 AGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGS 360
G S EG+ H + V+ ++ + + VV A S+V + + PA S
Sbjct: 1888 CGTSTEGMTHTQAVNLLKNASGSIEMQVV---AGGDVSVV-------TGHQQEPA----S 1933
Query: 361 SSASLVETEDPSLEDTSVPSVPLGSRQC---FLYPGPGGSYGFRLSCVASGPR----LFI 413
SS S L +S+ LG QC L GP G GF + P +++
Sbjct: 1934 SSLSFT-----GLTSSSIFQDDLGPPQCKSITLERGPDG-LGFSIVGGYGSPHGDLPIYV 1987
Query: 414 SQVTPGGSAARAG-LQVGDVILEVNGYPVGG 443
V G+A+ G L+ GD I+ VNG + G
Sbjct: 1988 KTVFAKGAASEDGRLKRGDQIIAVNGQSLEG 2018
Score = 50.1 bits (118), Expect = 5e-06
Identities = 78/337 (23%), Positives = 129/337 (38%), Gaps = 39/337 (11%)
Query: 30 LSLAEDHDPYDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQG- 88
L+L D PY + L K+ GK G + + G V + G A G
Sbjct: 1706 LTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGR 1765
Query: 89 LQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPT 148
L +GD+IL VN + V + V ++ S + + + E +
Sbjct: 1766 LMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESL--ESSSKKNA 1823
Query: 149 LGPGVRP-RLCHIVKDE-GGFGFSVTHGNQGPFW-------LVLSTGGAAERAGVPPGAR 199
L ++ R + K G S+ G P ++ TG AA+ + G R
Sbjct: 1824 LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDR 1883
Query: 200 LLEVNGLWQSG----QQVTLL-----------VAGPEVEEQCRQLGLPLAAPLAEGWALP 244
++ + G G Q V LL VAG +V P ++ L+
Sbjct: 1884 IVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTS 1943
Query: 245 TK--------PRC--LHLEKGPQGFGFLLREEKGLD--GRPGQFLWEVDPGLPAKKAGMQ 292
+ P+C + LE+GP G GF + G P G ++ ++
Sbjct: 1944 SSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLK 2003
Query: 293 AGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVV 329
GD+++AV G+S+EG+ HEE V+ ++ V+L V+
Sbjct: 2004 RGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 46.2 bits (108), Expect = 7e-05
Identities = 59/207 (28%), Positives = 86/207 (41%), Gaps = 26/207 (12%)
Query: 250 LHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLG 309
L L K G G + EE L G + L E G+ A ++ GD+++AV E V G
Sbjct: 1484 LELPKDQGGLGIAISEEDTLSGVIIKSLTE--HGVAATDGRLKVGDQILAVDDEIVVGYP 1541
Query: 310 HEETVSRIQGQGSCVSLTV--VDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVE 367
E+ +S ++ V LT+ +P++ S + ++++ PQ S
Sbjct: 1542 IEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGS------ 1595
Query: 368 TEDPSLEDTSVPSVPL----GSRQCFLYPG-------PGGSYGFRLSCVASGPRL----F 412
E S+ +TS S P C + PG G G LS V L
Sbjct: 1596 PEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII 1655
Query: 413 ISQVTPGGSAARAG-LQVGDVILEVNG 438
I +V G+A + G L GD ILEVNG
Sbjct: 1656 IHEVYEEGAACKDGRLWAGDQILEVNG 1682
Score = 32.3 bits (72), Expect = 1.0
Identities = 42/166 (25%), Positives = 68/166 (40%), Gaps = 19/166 (11%)
Query: 239 EGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRL 297
E W P+K + + G +G G L + + G F+ V PA K G ++ GDR+
Sbjct: 1153 ELWREPSKSLGISIVGG-RGMGSRLSNGEVMRGI---FIKHVLEDSPAGKNGTLKPGDRI 1208
Query: 298 VAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAP--- 354
V V G + HE+ V I+ G+ V V + R SPL L + P
Sbjct: 1209 VEVDGMDLRDASHEQAVEAIRKAGNPVVFMV-----QSIINRPRKSPLPSLLHNLYPKYN 1263
Query: 355 --ASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSY 398
++ + S + + PS ++ PL C + P P ++
Sbjct: 1264 FSSTNPFADSLQINADKAPSQSESEPEKAPL----CSVPPPPPSAF 1305
Score = 32.0 bits (71), Expect = 1.3
Identities = 98/408 (24%), Positives = 156/408 (38%), Gaps = 76/408 (18%)
Query: 61 GFHLQQELGRAGHVVCRVDPGTSAQRQG-LQEGDRILAVNNDVVEHEDYAVVVRRIRASS 119
G+ ++L +G V + ++ + G +Q GD+I+AV+ ++ V +R +
Sbjct: 393 GYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTG 452
Query: 120 PRVLLTVLAR----HAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGN 175
VLLT++ R A ++R + +DA L P ++ + KDE F S + N
Sbjct: 453 QTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKE---NYEKDE-DFLSSTRNTN 508
Query: 176 QGPFWLVLSTGGAAERAGVP-PGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLA 234
P E G P A + E+ + Q+ LL + +G+
Sbjct: 509 ILP----------TEEEGYPLLSAEIEEIEDAQK--QEAALLTKWQRI------MGINYE 550
Query: 235 APLAEGWALPTKPRCLHLEKGPQ--GFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-M 291
+A H+ K + G G L G F+ V P P +G +
Sbjct: 551 IVVA------------HVSKFSENSGLGISLEATVG-----HHFIRSVLPEGPVGHSGKL 593
Query: 292 QAGDRLVAVAGESVEGLGHEETVS-----RIQGQGSCVSLTVVDPEADRFFSMVRLSPLL 346
+GD L+ V G ++ G H++ V+ I+ C TV S+ L
Sbjct: 594 FSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL----DLC 649
Query: 347 FLENTEAPASPQGSSSASLVETEDPSL------EDTSVPSVPL-----GSRQCFLYPGPG 395
+E TE P G S ETEDP L + T PL G + L G
Sbjct: 650 DIELTEKPHVDLGEFIGS-SETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSK 708
Query: 396 GSYGFRL-----SCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVN 437
G GF + + + I + PGG A + G L GD ++ VN
Sbjct: 709 G-LGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Score = 30.4 bits (67), Expect = 3.8
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 5/55 (9%)
Query: 396 GSYGFRLSCVASGPR----LFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQN 445
G G LS + R +FI + P G+A + G LQ+ D +LE+NG + G++
Sbjct: 1356 GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 57.4 bits (137), Expect = 3e-08
Identities = 84/330 (25%), Positives = 124/330 (37%), Gaps = 55/330 (16%)
Query: 162 KDEGGFGFSVTHGNQGP---------FWLVLSTGGAAERAGVPPGARLLEVNGLWQSGQQ 212
+ G GFS+ G P ++ G AAE + +L VN + S
Sbjct: 52 RGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVS 111
Query: 213 VTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGR 272
+ V + +L + P+ E + L KGP+G GF + G
Sbjct: 112 HSKAVEALKEAGSIVRLYVRRRRPILETVVE------IKLFKGPKGLGFSIAGGVGNQHI 165
Query: 273 PGQ---FLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTV 328
PG ++ ++ G A+K G +Q GDRL+ V S+E + HEE V+ ++ V L V
Sbjct: 166 PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225
Query: 329 ------------VDPEADRFFSMVRLSPLLFLEN------TEAPASPQG----------- 359
P+ +S + LL N T P G
Sbjct: 226 GKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLV 285
Query: 360 -----SSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFIS 414
S S T PS+ S+ R+ L+ G G GF + G +F+S
Sbjct: 286 DDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG-LGFNIVGGEDGEGIFVS 344
Query: 415 QVTPGGSAARAG-LQVGDVILEVNGYPVGG 443
+ GG A +G LQ GD IL VNG + G
Sbjct: 345 FILAGGPADLSGELQRGDQILSVNGIDLRG 374
Score = 46.2 bits (108), Expect = 7e-05
Identities = 65/254 (25%), Positives = 104/254 (40%), Gaps = 35/254 (13%)
Query: 75 VCRVDPGTSAQRQG-LQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHD 133
V ++ G +AQ+ G LQ GDR+L VNN +E + V ++ +S V L V
Sbjct: 173 VTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV------- 225
Query: 134 VARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAG 193
G+ + T P P + H + GN G S +
Sbjct: 226 ------GKPTTIYMT-DPYGPPDITHSYSPP--MENHLLSGNNGTLEYKTSLPPISPGRY 276
Query: 194 VPPGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLE 253
P +L V+ + S Q + P + L +L +PR + L
Sbjct: 277 SPIPKHML-VDDDYTSHSQHSTATRQPSMT-------------LQRAVSLEGEPRKVVLH 322
Query: 254 KGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEE 312
KG G GF + G DG G F+ + G PA +G +Q GD++++V G + G HE+
Sbjct: 323 KGSTGLGFNI--VGGEDGE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 379
Query: 313 TVSRIQGQGSCVSL 326
+ ++G G V++
Sbjct: 380 AAAALKGAGQTVTI 393
Score = 36.6 bits (83), Expect = 0.053
Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Query: 405 VASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQLPEA 456
+ P +FI+++ PGG+AA G L+V D IL VN V + + ++ L EA
Sbjct: 70 IGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEA 122
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 56.6 bits (135), Expect = 5e-08
Identities = 73/243 (30%), Positives = 105/243 (43%), Gaps = 53/243 (21%)
Query: 244 PTKPRCLHLE-KGPQGFGFLLREEKGLDGRPGQF---LWEVDPGLPAKKAG-MQAGDRLV 298
P +P + L+ K +GFGF++ K PG + V G PA + G ++ GD +
Sbjct: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPP-PGVIPHKIGRVIEGSPADRCGKLKVGDHIS 904
Query: 299 AVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADR----FFSMVRLSPLLFLENTEAP 354
AV G+S+ L H+ V I+ G V+LTV+ E + R SP L
Sbjct: 905 AVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPAL-------Q 957
Query: 355 ASPQGSSSASLVETEDPSLE------------------------DTSVPSVPLGSRQ--- 387
P G S A+ + + +LE DT+V SV +GSR
Sbjct: 958 HRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV-VGSRHNQN 1016
Query: 388 --CF---LYPGPGGSYGFRL-SCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYP 440
C+ L GP G +GF L LFI ++ G A + G + VGD I+E+NG P
Sbjct: 1017 LGCYPVELERGPRG-FGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
Query: 441 VGG 443
G
Sbjct: 1076 TQG 1078
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Query: 45 ERPRFCLLSKEEGKSFGFHL-----QQELGRAGHVVCRVDPGTSAQRQG-LQEGDRILAV 98
+ P +L ++E + FGF + + G H + RV G+ A R G L+ GD I AV
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 99 NNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAH 132
N + + +V+ I+ + V LTV+A H
Sbjct: 907 NGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940
Score = 38.9 bits (89), Expect = 0.011
Identities = 70/282 (24%), Positives = 118/282 (41%), Gaps = 39/282 (13%)
Query: 196 PGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKG 255
PGA +LE NG +SG TL G + + +A+ + L T P L KG
Sbjct: 533 PGAMVLEQNG--KSGH--TLTGDGLNGPSDASEQRVSMASSGSSQPELVTIP----LIKG 584
Query: 256 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKA-GMQAGDRLVAVAGESVEGLGHEETV 314
P+GFGF + D GQ +V L ++ G+Q GD + + ++V+ L H + V
Sbjct: 585 PKGFGFAI-----ADSPTGQ---KVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVV 636
Query: 315 SRIQ--GQGSCVSLTVV-----DPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVE 367
++ G+ V L ++ P + LE P S++
Sbjct: 637 EVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIR 696
Query: 368 TEDPSLEDTSV--------PSVPLGSR--QCFLYPGPGGSYGFRLSCVASGP--RLFISQ 415
+ P L+ + V P ++ FL G +GFR+ GP ++I
Sbjct: 697 SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESG-FGFRV-LGGDGPDQSIYIGA 754
Query: 416 VTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQLPEA 456
+ P G+A + G L+ D ++ ++G PV G++ + L + A
Sbjct: 755 IIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTA 796
Score = 35.4 bits (80), Expect = 0.12
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 29/208 (13%)
Query: 245 TKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGE 303
TK + L K GFGF + G D ++ + P A+K G ++A D L+ + G
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGPD--QSIYIGAIIPLGAAEKDGRLRAADELMCIDGI 779
Query: 304 SVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSA 363
V+G H++ L ++ A ++ + +F + P+ SS
Sbjct: 780 PVKGKSHKQV------------LDLMTTAARNGHVLLTVRRKIFYGEKQ----PEDDSSQ 823
Query: 364 SLVETED--PSLEDTSVPSVPLGSR--QCFLYPGPGGSYGFRLSCVASGP-----RLFIS 414
+ + T++ P L VP+ P L +GF + + P I
Sbjct: 824 AFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIG 883
Query: 415 QVTPGGSAARAG-LQVGDVILEVNGYPV 441
+V G A R G L+VGD I VNG +
Sbjct: 884 RVIEGSPADRCGKLKVGDHISAVNGQSI 911
Score = 32.7 bits (73), Expect = 0.77
Identities = 25/80 (31%), Positives = 35/80 (43%), Gaps = 7/80 (8%)
Query: 391 YPGPGGSYGFRLSCVASG---PRLFISQVTPGGSA----ARAGLQVGDVILEVNGYPVGG 443
+ GP G +G + A P L + PGG + GDV+LEVNG PV G
Sbjct: 22 WAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSG 81
Query: 444 QNDLERLQQLPEAEPPLCLK 463
+ + L + P+ LK
Sbjct: 82 LTNRDTLAVIRHFREPIRLK 101
Score = 31.6 bits (70), Expect = 1.7
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 29/135 (21%)
Query: 162 KDEGGFGFSVTHGNQGPFWL----VLSTGGAAERAGVPPGARLLEVNGLWQSG------- 210
K GFGF++ G++ +L VL G AA+ + PG ++++NG G
Sbjct: 415 KSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV 474
Query: 211 QQVTLLVAGPEVE-EQCRQLGLP-----------LAAPLAEGWALPTKPRCLHLEKGPQG 258
Q L+ V CR LP A P+ G +L C++ PQ
Sbjct: 475 QMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMN----PQD 530
Query: 259 F--GFLLREEKGLDG 271
F G ++ E+ G G
Sbjct: 531 FKPGAMVLEQNGKSG 545
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 56.6 bits (135), Expect = 5e-08
Identities = 73/243 (30%), Positives = 105/243 (43%), Gaps = 53/243 (21%)
Query: 244 PTKPRCLHLE-KGPQGFGFLLREEKGLDGRPGQF---LWEVDPGLPAKKAG-MQAGDRLV 298
P +P + L+ K +GFGF++ K PG + V G PA + G ++ GD +
Sbjct: 846 PQEPYDVVLQRKENEGFGFVILTSKNKPP-PGVIPHKIGRVIEGSPADRCGKLKVGDHIS 904
Query: 299 AVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADR----FFSMVRLSPLLFLENTEAP 354
AV G+S+ L H+ V I+ G V+LTV+ E + R SP L
Sbjct: 905 AVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPAL-------Q 957
Query: 355 ASPQGSSSASLVETEDPSLE------------------------DTSVPSVPLGSRQ--- 387
P G S A+ + + +LE DT+V SV +GSR
Sbjct: 958 HRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISV-VGSRHNQN 1016
Query: 388 --CF---LYPGPGGSYGFRL-SCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYP 440
C+ L GP G +GF L LFI ++ G A + G + VGD I+E+NG P
Sbjct: 1017 LGCYPVELERGPRG-FGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEP 1075
Query: 441 VGG 443
G
Sbjct: 1076 TQG 1078
Score = 40.0 bits (92), Expect = 0.005
Identities = 29/94 (30%), Positives = 46/94 (48%), Gaps = 6/94 (6%)
Query: 45 ERPRFCLLSKEEGKSFGFHL-----QQELGRAGHVVCRVDPGTSAQRQG-LQEGDRILAV 98
+ P +L ++E + FGF + + G H + RV G+ A R G L+ GD I AV
Sbjct: 847 QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 99 NNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAH 132
N + + +V+ I+ + V LTV+A H
Sbjct: 907 NGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEH 940
Score = 38.9 bits (89), Expect = 0.011
Identities = 70/282 (24%), Positives = 118/282 (41%), Gaps = 39/282 (13%)
Query: 196 PGARLLEVNGLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKG 255
PGA +LE NG +SG TL G + + +A+ + L T P L KG
Sbjct: 533 PGAMVLEQNG--KSGH--TLTGDGLNGPSDASEQRVSMASSGSSQPELVTIP----LIKG 584
Query: 256 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKA-GMQAGDRLVAVAGESVEGLGHEETV 314
P+GFGF + D GQ +V L ++ G+Q GD + + ++V+ L H + V
Sbjct: 585 PKGFGFAI-----ADSPTGQ---KVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVV 636
Query: 315 SRIQ--GQGSCVSLTVV-----DPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASLVE 367
++ G+ V L ++ P + LE P S++
Sbjct: 637 EVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIR 696
Query: 368 TEDPSLEDTSV--------PSVPLGSR--QCFLYPGPGGSYGFRLSCVASGP--RLFISQ 415
+ P L+ + V P ++ FL G +GFR+ GP ++I
Sbjct: 697 SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESG-FGFRV-LGGDGPDQSIYIGA 754
Query: 416 VTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQLPEA 456
+ P G+A + G L+ D ++ ++G PV G++ + L + A
Sbjct: 755 IIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTA 796
Score = 35.4 bits (80), Expect = 0.12
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 29/208 (13%)
Query: 245 TKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGE 303
TK + L K GFGF + G D ++ + P A+K G ++A D L+ + G
Sbjct: 722 TKDLDVFLRKQESGFGFRVLGGDGPD--QSIYIGAIIPLGAAEKDGRLRAADELMCIDGI 779
Query: 304 SVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSA 363
V+G H++ L ++ A ++ + +F + P+ SS
Sbjct: 780 PVKGKSHKQV------------LDLMTTAARNGHVLLTVRRKIFYGEKQ----PEDDSSQ 823
Query: 364 SLVETED--PSLEDTSVPSVPLGSR--QCFLYPGPGGSYGFRLSCVASGP-----RLFIS 414
+ + T++ P L VP+ P L +GF + + P I
Sbjct: 824 AFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIG 883
Query: 415 QVTPGGSAARAG-LQVGDVILEVNGYPV 441
+V G A R G L+VGD I VNG +
Sbjct: 884 RVIEGSPADRCGKLKVGDHISAVNGQSI 911
Score = 32.7 bits (73), Expect = 0.77
Identities = 25/80 (31%), Positives = 35/80 (43%), Gaps = 7/80 (8%)
Query: 391 YPGPGGSYGFRLSCVASG---PRLFISQVTPGGSA----ARAGLQVGDVILEVNGYPVGG 443
+ GP G +G + A P L + PGG + GDV+LEVNG PV G
Sbjct: 22 WAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSG 81
Query: 444 QNDLERLQQLPEAEPPLCLK 463
+ + L + P+ LK
Sbjct: 82 LTNRDTLAVIRHFREPIRLK 101
Score = 31.6 bits (70), Expect = 1.7
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 29/135 (21%)
Query: 162 KDEGGFGFSVTHGNQGPFWL----VLSTGGAAERAGVPPGARLLEVNGLWQSG------- 210
K GFGF++ G++ +L VL G AA+ + PG ++++NG G
Sbjct: 415 KSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV 474
Query: 211 QQVTLLVAGPEVE-EQCRQLGLP-----------LAAPLAEGWALPTKPRCLHLEKGPQG 258
Q L+ V CR LP A P+ G +L C++ PQ
Sbjct: 475 QMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMN----PQD 530
Query: 259 F--GFLLREEKGLDG 271
F G ++ E+ G G
Sbjct: 531 FKPGAMVLEQNGKSG 545
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 52.0 bits (123), Expect = 1e-06
Identities = 75/307 (24%), Positives = 127/307 (41%), Gaps = 48/307 (15%)
Query: 125 TVLARHAHDVARAQLGEDAHLCPTLGPGVRPR---LCHIVKDEGGFGFSVTHGNQ----- 176
+++ R H ++ L CP P + +VK++G GFSVT G
Sbjct: 893 SLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY 952
Query: 177 -GPFWLVLSTGGAAERAG-VPPGARLLEVNGLWQSGQ-------------QVTLLVAG-- 219
G + + GG A + G + G RLL+V+G+ G QV LV
Sbjct: 953 GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERR 1012
Query: 220 -PEVEEQCRQLGLPLA---APLAEGWALPTKPR-CLHLEKGPQ------------GFGFL 262
P +QC + ++ ALP +P C+ + GP+ GF F+
Sbjct: 1013 VPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFV 1072
Query: 263 LREEKGLDGRPGQF--LWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQG 319
E++ + + PG PA++ G + AGD ++AV G S EGL +E + ++G
Sbjct: 1073 QMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRG 1132
Query: 320 QGSCVSLTVVDPEADRFFSMVR--LSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTS 377
V+L + P + + +P L + A+ S ++ +++ ED S D++
Sbjct: 1133 APQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQED-SWRDSA 1191
Query: 378 VPSVPLG 384
P G
Sbjct: 1192 SPDAGEG 1198
Score = 37.0 bits (84), Expect = 0.041
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 252 LEKGP-QGFGFLLRE-EKGLDGRPGQFLWEVDPGLPAKKA-GMQAGDRLVAVAGESVEGL 308
L++ P +GFGF++ E E PG F+ + PG PA+KA ++ G +++A+ S+EG
Sbjct: 756 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 815
Query: 309 GHEETVSRIQGQGSCVSLTV 328
V IQ + L +
Sbjct: 816 TFNMAVRMIQNSPDNIELII 835
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 52.0 bits (123), Expect = 1e-06
Identities = 75/307 (24%), Positives = 127/307 (41%), Gaps = 48/307 (15%)
Query: 125 TVLARHAHDVARAQLGEDAHLCPTLGPGVRPR---LCHIVKDEGGFGFSVTHGNQ----- 176
+++ R H ++ L CP P + +VK++G GFSVT G
Sbjct: 915 SLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPY 974
Query: 177 -GPFWLVLSTGGAAERAG-VPPGARLLEVNGLWQSGQ-------------QVTLLVAG-- 219
G + + GG A + G + G RLL+V+G+ G QV LV
Sbjct: 975 GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERR 1034
Query: 220 -PEVEEQCRQLGLPLA---APLAEGWALPTKPR-CLHLEKGPQ------------GFGFL 262
P +QC + ++ ALP +P C+ + GP+ GF F+
Sbjct: 1035 VPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFV 1094
Query: 263 LREEKGLDGRPGQF--LWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQG 319
E++ + + PG PA++ G + AGD ++AV G S EGL +E + ++G
Sbjct: 1095 QMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRG 1154
Query: 320 QGSCVSLTVVDPEADRFFSMVR--LSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTS 377
V+L + P + + +P L + A+ S ++ +++ ED S D++
Sbjct: 1155 APQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQED-SWRDSA 1213
Query: 378 VPSVPLG 384
P G
Sbjct: 1214 SPDAGEG 1220
Score = 37.0 bits (84), Expect = 0.041
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 252 LEKGP-QGFGFLLRE-EKGLDGRPGQFLWEVDPGLPAKKA-GMQAGDRLVAVAGESVEGL 308
L++ P +GFGF++ E E PG F+ + PG PA+KA ++ G +++A+ S+EG
Sbjct: 778 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 837
Query: 309 GHEETVSRIQGQGSCVSLTV 328
V IQ + L +
Sbjct: 838 TFNMAVRMIQNSPDNIELII 857
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 51.6 bits (122), Expect = 2e-06
Identities = 57/216 (26%), Positives = 94/216 (43%), Gaps = 41/216 (18%)
Query: 250 LHLEKGPQGFGF-LLREEKGLDGRPGQFLWEVDP-GLPAKKAGMQAGDRLVAVAGESVEG 307
+ L+KGP+G GF ++ + + G F+ + P G K +Q+GDR++ V G V G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 308 LGHEETVSRIQG--QGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASL 365
EE V+ ++ QG SL + E FL E P + SL
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIARQEGH------------FLPR-ELKGEPD-CCALSL 489
Query: 366 VETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPR-------LFISQVTP 418
+E + E +PL GS G +S + R +FI +
Sbjct: 490 ETSEQLTFE------IPLND---------SGSAGLGVSLKGNKSRETGTDLGIFIKSIIH 534
Query: 419 GGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQL 453
GG+A + G L++ D ++ VNG + G+++ E ++ L
Sbjct: 535 GGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/187 (28%), Positives = 79/187 (42%), Gaps = 33/187 (17%)
Query: 162 KDEGGFGFSVT------HGNQGPFWL--VLSTGGAAERAGVPPGARLLEVNGLWQSGQQV 213
K G GF+V HG GP ++ +L G A + + G R+LEVNG +G+
Sbjct: 388 KGPEGLGFTVVTRDSSIHG-PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
Query: 214 TLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTK----PRCLHL---------------EK 254
LVA +Q L +A EG LP + P C L +
Sbjct: 447 EELVAMLRSTKQGETASLVIARQ--EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504
Query: 255 GPQGFGFLLREEKGLDGRP--GQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHE 311
G G G L+ K + G F+ + G A K G ++ D+L+AV GES+ G +
Sbjct: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
Query: 312 ETVSRIQ 318
E + ++
Sbjct: 565 EAMETLR 571
Score = 37.7 bits (86), Expect = 0.024
Identities = 43/124 (34%), Positives = 58/124 (46%), Gaps = 22/124 (17%)
Query: 350 NTEAPASPQGSSSASLVETEDPSLE----DTSVPSV-PL---GSRQ------CFLYPGPG 395
N SP+ +SASL + + P + S PS+ PL GS + L GP
Sbjct: 332 NLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPE 391
Query: 396 GSYGFRL-----SCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLER 449
G GF + S GP +F+ + P G+A + G LQ GD ILEVNG V G+ E
Sbjct: 392 G-LGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
Query: 450 LQQL 453
+ L
Sbjct: 450 VAML 453
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 51.6 bits (122), Expect = 2e-06
Identities = 57/216 (26%), Positives = 94/216 (43%), Gaps = 41/216 (18%)
Query: 250 LHLEKGPQGFGF-LLREEKGLDGRPGQFLWEVDP-GLPAKKAGMQAGDRLVAVAGESVEG 307
+ L+KGP+G GF ++ + + G F+ + P G K +Q+GDR++ V G V G
Sbjct: 384 IDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTG 443
Query: 308 LGHEETVSRIQG--QGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASL 365
EE V+ ++ QG SL + E FL E P + SL
Sbjct: 444 RTQEELVAMLRSTKQGETASLVIARQEGH------------FLPR-ELKGEPD-CCALSL 489
Query: 366 VETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPR-------LFISQVTP 418
+E + E +PL GS G +S + R +FI +
Sbjct: 490 ETSEQLTFE------IPLND---------SGSAGLGVSLKGNKSRETGTDLGIFIKSIIH 534
Query: 419 GGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQL 453
GG+A + G L++ D ++ VNG + G+++ E ++ L
Sbjct: 535 GGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETL 570
Score = 42.0 bits (97), Expect = 0.001
Identities = 53/187 (28%), Positives = 79/187 (42%), Gaps = 33/187 (17%)
Query: 162 KDEGGFGFSVT------HGNQGPFWL--VLSTGGAAERAGVPPGARLLEVNGLWQSGQQV 213
K G GF+V HG GP ++ +L G A + + G R+LEVNG +G+
Sbjct: 388 KGPEGLGFTVVTRDSSIHG-PGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446
Query: 214 TLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTK----PRCLHL---------------EK 254
LVA +Q L +A EG LP + P C L +
Sbjct: 447 EELVAMLRSTKQGETASLVIARQ--EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504
Query: 255 GPQGFGFLLREEKGLDGRP--GQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGLGHE 311
G G G L+ K + G F+ + G A K G ++ D+L+AV GES+ G +
Sbjct: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564
Query: 312 ETVSRIQ 318
E + ++
Sbjct: 565 EAMETLR 571
Score = 37.7 bits (86), Expect = 0.024
Identities = 43/124 (34%), Positives = 58/124 (46%), Gaps = 22/124 (17%)
Query: 350 NTEAPASPQGSSSASLVETEDPSLE----DTSVPSV-PL---GSRQ------CFLYPGPG 395
N SP+ +SASL + + P + S PS+ PL GS + L GP
Sbjct: 332 NLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPE 391
Query: 396 GSYGFRL-----SCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLER 449
G GF + S GP +F+ + P G+A + G LQ GD ILEVNG V G+ E
Sbjct: 392 G-LGFTVVTRDSSIHGPGP-IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEEL 449
Query: 450 LQQL 453
+ L
Sbjct: 450 VAML 453
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 50.4 bits (119), Expect = 4e-06
Identities = 54/219 (24%), Positives = 96/219 (43%), Gaps = 33/219 (15%)
Query: 250 LHLEKGPQGFGF-LLREEKGLDGRPGQFLWEVDP-GLPAKKAGMQAGDRLVAVAGESVEG 307
+ L+KG +G GF + + + G ++ + P G + ++AGDRL+ V G + G
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVG 521
Query: 308 LGHEETVSRIQG--QGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPQGSSSASL 365
EE VS ++ VSL V E D F E A P + +
Sbjct: 522 KSQEEVVSLLRSTKMEGTVSLLVFRQE-DAF------------HPRELNAEP-----SQM 563
Query: 366 VETEDPSLEDTSVPSVPLGSRQCFLYPGP---GGSYGFRLSCVASGPR-------LFISQ 415
++ ED + P G+R+ + P GS G +S + + +F+
Sbjct: 564 QIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKS 623
Query: 416 VTPGGSAARAG-LQVGDVILEVNGYPVGGQNDLERLQQL 453
+ GG+A++ G L+V D ++ VNG + G+ + + ++ L
Sbjct: 624 IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETL 662
Score = 32.0 bits (71), Expect = 1.3
Identities = 44/198 (22%), Positives = 78/198 (39%), Gaps = 41/198 (20%)
Query: 162 KDEGGFGFSVTH-----GNQGPFWL--VLSTGGAAERAGVPPGARLLEVNGLWQSGQQ-- 212
K G GFS+T G P ++ +L G A + + G RL+EVNG+ G+
Sbjct: 466 KGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQE 525
Query: 213 --------------VTLLVAGP-------EVEEQCRQLGLPLAAPLAEGWALPTKPRCLH 251
V+LLV E+ + Q+ +P + + T
Sbjct: 526 EVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTRE 585
Query: 252 L--------EKGPQGFGFLLREEKGLDGRP--GQFLWEVDPGLPAKKAG-MQAGDRLVAV 300
+ G G G ++ + + G F+ + G A K G ++ D+L+AV
Sbjct: 586 FLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAV 645
Query: 301 AGESVEGLGHEETVSRIQ 318
GES+ G +++ + ++
Sbjct: 646 NGESLLGKTNQDAMETLR 663
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 49.7 bits (117), Expect = 6e-06
Identities = 52/212 (24%), Positives = 94/212 (44%), Gaps = 22/212 (10%)
Query: 246 KPRCLHLEKGP-QGFGFLL-----REEKGLD------GRPGQFLWEVDPGLPAKKAG-MQ 292
+P + + +G +GFGF++ R E G P + + + G PA + G ++
Sbjct: 967 QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLK 1025
Query: 293 AGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTE 352
GDR++AV G S+ H + V+ I+ G+ V+L ++ + +++ + + T
Sbjct: 1026 VGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTT 1085
Query: 353 APASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGP--GGSYGFRLSCVAS--- 407
S QG+ T P E P +++ Y G+ GF S
Sbjct: 1086 HTPSQQGTQETR--NTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY 1143
Query: 408 GPRLFISQVTPGGSAARAG-LQVGDVILEVNG 438
L++ ++ G A R G +++GD ILE+NG
Sbjct: 1144 NMDLYVLRLAEDGPAERCGKMRIGDEILEING 1175
Score = 43.5 bits (101), Expect = 4e-04
Identities = 63/259 (24%), Positives = 105/259 (40%), Gaps = 53/259 (20%)
Query: 242 ALPTKPRCL--HLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVA 299
++ T+P + H+ KGP GFGF + + G G+ + + + + G++ GD +V
Sbjct: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVD-----SPRCRGLKEGDLIVE 688
Query: 300 VAGESVEGLGHEETVSRIQ--GQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASP 357
V ++V+ L H + V + +GS V+L V + P LE ++ S
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQP---LERKDSQNSS 745
Query: 358 QGS-SSASLVETEDPSLEDTSVPSVPLGSRQC---------------------------- 388
Q S SS + T PS +P P Q
Sbjct: 746 QHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENR 805
Query: 389 ---------FLYPGPGGSYGFR-LSCVASGPRLFISQVTPGGSAARAG-LQVGDVILEVN 437
FL+ G +GFR L G ++I + P G+A G L+ GD ++ V+
Sbjct: 806 LPDYQEQDIFLWRKETG-FGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVD 864
Query: 438 GYPVGGQNDLERLQQLPEA 456
G PV G++ +Q + +A
Sbjct: 865 GTPVIGKSHQLVVQLMQQA 883
Score = 40.0 bits (92), Expect = 0.005
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 12/96 (12%)
Query: 250 LHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGL 308
+ LE+G +GFGF LR G + ++ + PA++ G M+ GD ++ + GE+ + +
Sbjct: 1124 VELERGAKGFGFSLRG--GREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNM 1181
Query: 309 GHEETVSRIQGQGSCV---------SLTVVDPEADR 335
H + I+ G V S+ DP +DR
Sbjct: 1182 KHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDR 1217
Score = 38.1 bits (87), Expect = 0.018
Identities = 50/205 (24%), Positives = 81/205 (39%), Gaps = 53/205 (25%)
Query: 52 LSKEEGKSFGFHLQQELGR--AG-----------HVVCRVDPGTSAQRQG-LQEGDRILA 97
+ + E + FGF + + R AG H + R+ G+ A R G L+ GDRILA
Sbjct: 973 IRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILA 1032
Query: 98 VNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPR- 156
VN + ++ ++ +V I+ + V L ++ + + A L +A T+ P
Sbjct: 1033 VNGCSITNKSHSDIVNLIKEAGNTVTLRIIP--GDESSNATLLTNAEKIATITTTHTPSQ 1090
Query: 157 --------------------------------LCHIVKDEGGFGFSVTHG---NQGPFWL 181
+ + GFGFS+ G N + L
Sbjct: 1091 QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVL 1150
Query: 182 VLSTGGAAERAG-VPPGARLLEVNG 205
L+ G AER G + G +LE+NG
Sbjct: 1151 RLAEDGPAERCGKMRIGDEILEING 1175
Score = 34.3 bits (77), Expect = 0.26
Identities = 66/259 (25%), Positives = 98/259 (37%), Gaps = 67/259 (25%)
Query: 261 FLLREEKGLDGR------PGQ--FLWEVDP-GLPAKKAGMQAGDRLVAVAGESVEGLGHE 311
FL R+E G R PG+ ++ + P G +++GD L+ V G V G H+
Sbjct: 815 FLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQ 874
Query: 312 ETVSRIQ--GQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTE----APASPQGSSS--A 363
V +Q + V+LTV R + + TE +PAS SS+ A
Sbjct: 875 LVVQLMQQAAKQGHVNLTV------------RRKVVFAVPKTENEVPSPASSHHSSNQPA 922
Query: 364 SLVE---TEDPSLEDTSVPSVPLGSRQCFLYPGPGGS---------------------YG 399
SL E T S + S GS G GGS +G
Sbjct: 923 SLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFG 982
Query: 400 FRLSCVASGPRLF-------------ISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQN 445
F + S P I ++ G A R G L+VGD IL VNG + ++
Sbjct: 983 FVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKS 1042
Query: 446 DLERLQQLPEAEPPLCLKL 464
+ + + EA + L++
Sbjct: 1043 HSDIVNLIKEAGNTVTLRI 1061
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 49.7 bits (117), Expect = 6e-06
Identities = 52/212 (24%), Positives = 94/212 (44%), Gaps = 22/212 (10%)
Query: 246 KPRCLHLEKGP-QGFGFLL-----REEKGLD------GRPGQFLWEVDPGLPAKKAG-MQ 292
+P + + +G +GFGF++ R E G P + + + G PA + G ++
Sbjct: 995 QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLK 1053
Query: 293 AGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTE 352
GDR++AV G S+ H + V+ I+ G+ V+L ++ + +++ + + T
Sbjct: 1054 VGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTT 1113
Query: 353 APASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGP--GGSYGFRLSCVAS--- 407
S QG+ T P E P +++ Y G+ GF S
Sbjct: 1114 HTPSQQGTQETR--NTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY 1171
Query: 408 GPRLFISQVTPGGSAARAG-LQVGDVILEVNG 438
L++ ++ G A R G +++GD ILE+NG
Sbjct: 1172 NMDLYVLRLAEDGPAERCGKMRIGDEILEING 1203
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 13/151 (8%)
Query: 242 ALPTKPRCL--HLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVA 299
++ T+P + H+ KGP GFGF + + G G+ + + + + G++ GD +V
Sbjct: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVD-----SPRCRGLKEGDLIVE 688
Query: 300 VAGESVEGLGHEETVSRIQ--GQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASP 357
V ++V+ L H + V + +GS V+L V + P LE ++ S
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQP---LERKDSQNSS 745
Query: 358 QGS-SSASLVETEDPSLEDTSVPSVPLGSRQ 387
Q S SS + T PS +P P Q
Sbjct: 746 QHSVSSHRSLHTASPSHSTQVLPEFPPAEAQ 776
Score = 38.9 bits (89), Expect = 0.011
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 3/78 (3%)
Query: 250 LHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGL 308
+ LE+G +GFGF LR G + ++ + PA++ G M+ GD ++ + GE+ + +
Sbjct: 1152 VELERGAKGFGFSLRG--GREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNM 1209
Query: 309 GHEETVSRIQGQGSCVSL 326
H + I+ G V L
Sbjct: 1210 KHSRAIELIKNGGRRVRL 1227
Score = 38.1 bits (87), Expect = 0.018
Identities = 50/205 (24%), Positives = 81/205 (39%), Gaps = 53/205 (25%)
Query: 52 LSKEEGKSFGFHLQQELGR--AG-----------HVVCRVDPGTSAQRQG-LQEGDRILA 97
+ + E + FGF + + R AG H + R+ G+ A R G L+ GDRILA
Sbjct: 1001 IRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILA 1060
Query: 98 VNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPR- 156
VN + ++ ++ +V I+ + V L ++ + + A L +A T+ P
Sbjct: 1061 VNGCSITNKSHSDIVNLIKEAGNTVTLRIIP--GDESSNATLLTNAEKIATITTTHTPSQ 1118
Query: 157 --------------------------------LCHIVKDEGGFGFSVTHG---NQGPFWL 181
+ + GFGFS+ G N + L
Sbjct: 1119 QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVL 1178
Query: 182 VLSTGGAAERAG-VPPGARLLEVNG 205
L+ G AER G + G +LE+NG
Sbjct: 1179 RLAEDGPAERCGKMRIGDEILEING 1203
Score = 34.3 bits (77), Expect = 0.26
Identities = 66/259 (25%), Positives = 98/259 (37%), Gaps = 67/259 (25%)
Query: 261 FLLREEKGLDGR------PGQ--FLWEVDP-GLPAKKAGMQAGDRLVAVAGESVEGLGHE 311
FL R+E G R PG+ ++ + P G +++GD L+ V G V G H+
Sbjct: 843 FLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQ 902
Query: 312 ETVSRIQ--GQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTE----APASPQGSSS--A 363
V +Q + V+LTV R + + TE +PAS SS+ A
Sbjct: 903 LVVQLMQQAAKQGHVNLTV------------RRKVVFAVPKTENEVPSPASSHHSSNQPA 950
Query: 364 SLVE---TEDPSLEDTSVPSVPLGSRQCFLYPGPGGS---------------------YG 399
SL E T S + S GS G GGS +G
Sbjct: 951 SLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFG 1010
Query: 400 FRLSCVASGPRLF-------------ISQVTPGGSAARAG-LQVGDVILEVNGYPVGGQN 445
F + S P I ++ G A R G L+VGD IL VNG + ++
Sbjct: 1011 FVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKS 1070
Query: 446 DLERLQQLPEAEPPLCLKL 464
+ + + EA + L++
Sbjct: 1071 HSDIVNLIKEAGNTVTLRI 1089
>gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2)
interacting protein [Homo sapiens]
Length = 1211
Score = 49.3 bits (116), Expect = 8e-06
Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 6/81 (7%)
Query: 248 RCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEG 307
R + + KG + FGF LR G ++ V PG PA A +++GDR++ + G +
Sbjct: 278 RTVRVYKGNKSFGFTLR------GHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRN 331
Query: 308 LGHEETVSRIQGQGSCVSLTV 328
H++ VS +QG G+ +L V
Sbjct: 332 CSHDKVVSMLQGSGAMPTLVV 352
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/61 (47%), Positives = 35/61 (57%), Gaps = 4/61 (6%)
Query: 398 YGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457
+GFRL SGP F+ +V G SA GL+ GD ILEV G VGG + ERL +L
Sbjct: 17 FGFRLG--GSGP-CFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLS-RERLVRLARRC 72
Query: 458 P 458
P
Sbjct: 73 P 73
Score = 35.0 bits (79), Expect = 0.16
Identities = 80/333 (24%), Positives = 116/333 (34%), Gaps = 84/333 (25%)
Query: 167 FGFSVTHGNQGP-FWLVLSTGGAAERAGVPPGARLLEVNGLWQSG----QQVTLLVAGPE 221
FGF + G GP F L ++ G +A G+ PG ++LEV GL G + V L P
Sbjct: 17 FGFRL--GGSGPCFVLEVAKGSSAHAGGLRPGDQILEVEGLAVGGLSRERLVRLARRCPR 74
Query: 222 VEEQCRQLGLPLAAP-LAEGWALPT----KPRC---------------------LHLEKG 255
V L P P G A PT PRC +H E+
Sbjct: 75 VPPSLGVLPAPDGGPGPGSGPAAPTTVLRAPRCGRGLALGRELLRLAGRKRPDAVHRERR 134
Query: 256 PQGFGFLLREEKGLDGRP-------------------GQFLWEVDPGLPAKKAGMQAGDR 296
+ F + ++ L +P +W + LP + G +
Sbjct: 135 RKAQEFSRKVDEILGDQPTAKEQVFAALKQFAAEQRVDDLVWTLTLALPREACGPLLDNL 194
Query: 297 LVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRL-------SPLLFLE 349
+ + + H + QG L A R RL P L
Sbjct: 195 RIFIPKK------HRARFDEVVSQGLLGKLC----RARRAQGAQRLRRSRSEERPERLLV 244
Query: 350 NTEAPASPQGSSSASLVETEDPSLEDTSV----PSVPLGSRQCFLYPGPGGSYGFRLSCV 405
+T A A P+ ++P S+ + P G+R+ S+GF L
Sbjct: 245 STRASAPPR--------RPDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLR-- 294
Query: 406 ASGPRLFISQVTPGGSAARAGLQVGDVILEVNG 438
GP ++I V PG A A L+ GD IL +NG
Sbjct: 295 GHGP-VWIESVLPGSPADNAALKSGDRILFLNG 326
Score = 34.7 bits (78), Expect = 0.20
Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 3/58 (5%)
Query: 150 GPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLV-LSTGGAAERAGVPPGARLLEVNGL 206
GPG R + K FGF++ GP W+ + G A+ A + G R+L +NGL
Sbjct: 272 GPGGARRTVRVYKGNKSFGFTLR--GHGPVWIESVLPGSPADNAALKSGDRILFLNGL 327
Score = 30.8 bits (68), Expect = 2.9
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Query: 58 KSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRA 117
KSFGF L+ G + V PG+ A L+ GDRIL +N + + + VV ++
Sbjct: 287 KSFGFTLR---GHGPVWIESVLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSMLQG 343
Query: 118 SSPRVLLTV 126
S L V
Sbjct: 344 SGAMPTLVV 352
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 49.3 bits (116), Expect = 8e-06
Identities = 34/110 (30%), Positives = 54/110 (49%), Gaps = 14/110 (12%)
Query: 47 PRFCLLSKEEGKSFGFHLQQELGRAGHV-------------VCRVDPGTSAQRQGLQEGD 93
PR + K E +GF+++ ++ G + V V PG +A R G+++GD
Sbjct: 41 PRVVRIVKSES-GYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGD 99
Query: 94 RILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDA 143
RIL VN+ VE + VV IRA ++LTVL+ H+ +D+
Sbjct: 100 RILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDS 149
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/101 (37%), Positives = 49/101 (48%), Gaps = 18/101 (17%)
Query: 150 GPGVRPRLCHIVKDEGGFGFSV----THGNQ-----GPFWLVLS------TGGAAERAGV 194
G G PR+ IVK E G+GF+V + G Q G + L GGAA+RAGV
Sbjct: 36 GGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGV 95
Query: 195 PPGARLLEVNGLWQSG---QQVTLLVAGPEVEEQCRQLGLP 232
G R+LEVN + G +QV L+ E E L +P
Sbjct: 96 RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136
Score = 43.9 bits (102), Expect = 3e-04
Identities = 37/124 (29%), Positives = 56/124 (45%), Gaps = 13/124 (10%)
Query: 247 PRCLHLEKGPQGFGFLLREEKGLDGR----------PGQFLWEVDPGLPAKKAGMQAGDR 296
PR + + K G+GF +R + G+ P Q + V PG A +AG++ GDR
Sbjct: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
Query: 297 LVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVD---PEADRFFSMVRLSPLLFLENTEA 353
++ V +VEG H++ V I+ + LTV+ EAD F + TE
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHEADNLDPSDDSLGQSFYDYTEK 160
Query: 354 PASP 357
A P
Sbjct: 161 QAVP 164
Score = 38.9 bits (89), Expect = 0.011
Identities = 27/83 (32%), Positives = 40/83 (48%), Gaps = 9/83 (10%)
Query: 409 PRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARS 468
P +S V PGG+A RAG++ GD ILEVN V G + + + E L L + +
Sbjct: 77 PLQHVSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLS-- 134
Query: 469 LRGLEAWIPPGAAEDWALASDLL 491
+PP A++ + D L
Sbjct: 135 -------VPPHEADNLDPSDDSL 150
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 49.3 bits (116), Expect = 8e-06
Identities = 42/163 (25%), Positives = 74/163 (45%), Gaps = 9/163 (5%)
Query: 283 GLPAKKAG-MQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVR 341
G PA + G ++ GDR++AV G S+ H + V+ I+ G+ V+L ++ + +++
Sbjct: 1044 GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLT 1103
Query: 342 LSPLLFLENTEAPASPQGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGP--GGSYG 399
+ + T S QG+ T P E P +++ Y G+ G
Sbjct: 1104 NAEKIATITTTHTPSQQGTQETR--NTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1161
Query: 400 FRLSCVAS---GPRLFISQVTPGGSAARAG-LQVGDVILEVNG 438
F S L++ ++ G A R G +++GD ILE+NG
Sbjct: 1162 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEING 1204
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/151 (26%), Positives = 67/151 (44%), Gaps = 13/151 (8%)
Query: 242 ALPTKPRCL--HLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVA 299
++ T+P + H+ KGP GFGF + + G G+ + + + + G++ GD +V
Sbjct: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVD-----SPRCRGLKEGDLIVE 688
Query: 300 VAGESVEGLGHEETVSRIQ--GQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASP 357
V ++V+ L H + V + +GS V+L V + P LE ++ S
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQP---LERKDSQNSS 745
Query: 358 QGS-SSASLVETEDPSLEDTSVPSVPLGSRQ 387
Q S SS + T PS +P P Q
Sbjct: 746 QHSVSSHRSLHTASPSHSTQVLPEFPPAEAQ 776
Score = 38.9 bits (89), Expect = 0.011
Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 3/78 (3%)
Query: 250 LHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAG-MQAGDRLVAVAGESVEGL 308
+ LE+G +GFGF LR G + ++ + PA++ G M+ GD ++ + GE+ + +
Sbjct: 1153 VELERGAKGFGFSLRG--GREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNM 1210
Query: 309 GHEETVSRIQGQGSCVSL 326
H + I+ G V L
Sbjct: 1211 KHSRAIELIKNGGRRVRL 1228
Score = 37.7 bits (86), Expect = 0.024
Identities = 50/206 (24%), Positives = 81/206 (39%), Gaps = 54/206 (26%)
Query: 52 LSKEEGKSFGFHLQQELGR-------AG-------HVVCRVDPGTSAQRQG-LQEGDRIL 96
+ + E + FGF + + R AG H + R+ G+ A R G L+ GDRIL
Sbjct: 1001 IRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRIL 1060
Query: 97 AVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPR 156
AVN + ++ ++ +V I+ + V L ++ + + A L +A T+ P
Sbjct: 1061 AVNGCSITNKSHSDIVNLIKEAGNTVTLRIIP--GDESSNATLLTNAEKIATITTTHTPS 1118
Query: 157 ---------------------------------LCHIVKDEGGFGFSVTHG---NQGPFW 180
+ + GFGFS+ G N +
Sbjct: 1119 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1178
Query: 181 LVLSTGGAAERAG-VPPGARLLEVNG 205
L L+ G AER G + G +LE+NG
Sbjct: 1179 LRLAEDGPAERCGKMRIGDEILEING 1204
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,605,111
Number of Sequences: 37866
Number of extensions: 1212383
Number of successful extensions: 3911
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 3090
Number of HSP's gapped (non-prelim): 759
length of query: 491
length of database: 18,247,518
effective HSP length: 106
effective length of query: 385
effective length of database: 14,233,722
effective search space: 5479982970
effective search space used: 5479982970
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.