Search of human proteins with 214010183

Search of human proteins with 214010183

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform
3 [Homo sapiens]
         (695 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform ...  1399   0.0  
gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform ...  1270   0.0  
gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1 ...  1261   0.0  
gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform ...   764   0.0  
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa...   666   0.0  
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa...   641   0.0  
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap...   640   0.0  
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s...   582   e-166
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s...   556   e-158
gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor ...   473   e-133
gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor...   472   e-133
gi|7662316 HIV-1 Vpr binding protein [Homo sapiens]                    60   9e-09
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    59   1e-08
gi|87299628 biorientation of chromosomes in cell division 1-like...    59   1e-08
gi|17975763 myelin transcription factor 1 [Homo sapiens]               58   3e-08
gi|4503257 death-domain associated protein isoform a [Homo sapiens]    57   4e-08
gi|215422388 death-domain associated protein isoform a [Homo sap...    57   4e-08
gi|215422366 death-domain associated protein isoform b [Homo sap...    57   4e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       57   8e-08
gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo...    57   8e-08
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     54   4e-07
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     54   4e-07
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    54   4e-07
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    54   4e-07
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    54   4e-07
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    54   4e-07
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...    54   4e-07
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    54   4e-07
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]    54   5e-07
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    54   5e-07

>gi|214010183 amyloid beta (A4) precursor-like protein 2 isoform 3
           [Homo sapiens]
          Length = 695

 Score = 1399 bits (3621), Expect = 0.0
 Identities = 695/695 (100%), Positives = 695/695 (100%)

Query: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
           MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60

Query: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
           MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120

Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
           KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180

Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
           LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240

Query: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300
           PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK
Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300

Query: 301 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE 360
           EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE
Sbjct: 301 EITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAE 360

Query: 361 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL 420
           LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL
Sbjct: 361 LQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYL 420

Query: 421 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI 480
           AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI
Sbjct: 421 AALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVI 480

Query: 481 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI 540
           EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI
Sbjct: 481 EERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEI 540

Query: 541 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA 600
           PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA
Sbjct: 541 PPFHPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNA 600

Query: 601 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI 660
           ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI
Sbjct: 601 ERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGI 660

Query: 661 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 695
           VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 661 VEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 695


>gi|214010181 amyloid beta (A4) precursor-like protein 2 isoform 2
           [Homo sapiens]
          Length = 751

 Score = 1270 bits (3287), Expect = 0.0
 Identities = 658/751 (87%), Positives = 667/751 (88%), Gaps = 56/751 (7%)

Query: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
           MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60

Query: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
           MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120

Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
           KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180

Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
           LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240

Query: 241 PTEADLEDFTEAAVDEDD----------EDEEEGEEVVEDRDYYYD--TFKGDD------ 282
           PTEADLEDFTEAAVDEDD          ED +   +  +  DY  +  T  G D      
Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300

Query: 283 ---------YNEENPTEP-----------------------GSDGTMSDKEITH------ 304
                     ++E  T P                       G  G  ++ E         
Sbjct: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360

Query: 305 DVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 364
              +PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
Sbjct: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420

Query: 365 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 424
           NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
Sbjct: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480

Query: 425 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 484
           SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
Sbjct: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540

Query: 485 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 544
           NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
Sbjct: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600

Query: 545 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG 604
           PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG
Sbjct: 601 PFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVG 660

Query: 605 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD 664
           GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD
Sbjct: 661 GLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVD 720

Query: 665 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI 695
           PMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 721 PMLTPEERHLNKMQNHGYENPTYKYLEQMQI 751


>gi|4502147 amyloid beta (A4) precursor-like protein 2 isoform 1
           [Homo sapiens]
          Length = 763

 Score = 1261 bits (3264), Expect = 0.0
 Identities = 658/763 (86%), Positives = 667/763 (87%), Gaps = 68/763 (8%)

Query: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
           MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60

Query: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
           MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120

Query: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180
           KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT
Sbjct: 121 KQCKSRFVTPFKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMT 180

Query: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240
           LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF
Sbjct: 181 LYSYGMLLPCGVDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEF 240

Query: 241 PTEADLEDFTEAAVDEDD----------EDEEEGEEVVEDRDYYYD--TFKGDD------ 282
           PTEADLEDFTEAAVDEDD          ED +   +  +  DY  +  T  G D      
Sbjct: 241 PTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDK 300

Query: 283 ---------YNEENPTEP-----------------------GSDGTMSDKEITH------ 304
                     ++E  T P                       G  G  ++ E         
Sbjct: 301 EITHDVKAVCSQEAMTGPCRAVMPRWYFDLSKGKCVRFIYGGCGGNRNNFESEDYCMAVC 360

Query: 305 DVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 364
              +PPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK
Sbjct: 361 KAMIPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAK 420

Query: 365 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 424
           NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ
Sbjct: 421 NLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQ 480

Query: 425 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 484
           SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR
Sbjct: 481 SDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERR 540

Query: 485 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 544
           NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH
Sbjct: 541 NQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFH 600

Query: 545 PFHPFPALPENE------------GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 592
           PFHPFPALPENE            GSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD
Sbjct: 601 PFHPFPALPENEDTQPELYHPMKKGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLD 660

Query: 593 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 652
           VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ
Sbjct: 661 VKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQ 720

Query: 653 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 695
           YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 721 YGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI 763


>gi|214010185 amyloid beta (A4) precursor-like protein 2 isoform 4
           [Homo sapiens]
          Length = 522

 Score =  764 bits (1972), Expect = 0.0
 Identities = 388/388 (100%), Positives = 388/388 (100%)

Query: 308 VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 367
           VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP
Sbjct: 135 VPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLP 194

Query: 368 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 427
           KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP
Sbjct: 195 KAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDP 254

Query: 428 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 487
           PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS
Sbjct: 255 PRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQS 314

Query: 488 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 547
           LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH
Sbjct: 315 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPFHPFH 374

Query: 548 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 607
           PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE
Sbjct: 375 PFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERVGGLE 434

Query: 608 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPML 667
           EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPML
Sbjct: 435 EERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPML 494

Query: 668 TPEERHLNKMQNHGYENPTYKYLEQMQI 695
           TPEERHLNKMQNHGYENPTYKYLEQMQI
Sbjct: 495 TPEERHLNKMQNHGYENPTYKYLEQMQI 522



 Score =  276 bits (706), Expect = 5e-74
 Identities = 135/135 (100%), Positives = 135/135 (100%)

Query: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60
           MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN
Sbjct: 1   MAATGTAAAAATGRLLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLN 60

Query: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120
           MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK
Sbjct: 61  MHVNIQTGKWEPDPTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDK 120

Query: 121 KQCKSRFVTPFKCLV 135
           KQCKSRFVTPFKCLV
Sbjct: 121 KQCKSRFVTPFKCLV 135


>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
           sapiens]
          Length = 695

 Score =  666 bits (1719), Expect = 0.0
 Identities = 362/709 (51%), Positives = 473/709 (66%), Gaps = 48/709 (6%)

Query: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56

Query: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116

Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
           CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+
Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176

Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTE 251
           D+F G E+VCCP  +   +V   + EED+ +      + DY D  + +    A+ E+  E
Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236

Query: 252 AAVDE--DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVP 309
              +E  DDED+E+G+EV E+ +  Y+         E  T   +  T + + +   V+VP
Sbjct: 237 VEEEEADDDEDDEDGDEVEEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVRVP 290

Query: 310 PTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPK 368
            T   T D VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPK
Sbjct: 291 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK 350

Query: 369 AERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPP 428
           A+++ +IQHFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PP
Sbjct: 351 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP 410

Query: 429 RPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSL 488
           RP  +   L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSL
Sbjct: 411 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL 470

Query: 489 SLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR 531
           SLLY VP VA+EIQ+E+DELLQ+++       A+M          D    S++ET   V 
Sbjct: 471 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE 530

Query: 532 ---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENM 585
              V+ E S +++ P+H F     PA  ENE   V  +      A+  +         N+
Sbjct: 531 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNI 586

Query: 586 VIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISL 645
             +E  +VK M        G E   + +    ED   +  A+IGL+V  V IATVIVI+L
Sbjct: 587 KTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL 645

Query: 646 VMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
           VML+K+QY +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 646 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 694


>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
           sapiens]
          Length = 751

 Score =  641 bits (1653), Expect = 0.0
 Identities = 367/760 (48%), Positives = 473/760 (62%), Gaps = 94/760 (12%)

Query: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56

Query: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116

Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
           CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+
Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176

Query: 193 DQFHGTEYVCCPQTKIIGSVSKEEEEEDEEE-------EEEEDEEEDYDVYKSEFPTEAD 245
           D+F G E+VCCP  +   +V   + EED+ +        +  D  ED  V  +E    A+
Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAE 236

Query: 246 LEDFTEAAVDEDDED----EEEGEEVVEDRD----------------------------- 272
           +E+  EA  DEDDED    EEE EE  E+                               
Sbjct: 237 VEE-EEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 295

Query: 273 -----------YYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDV---KVPPTPLPTND- 317
                      +Y+D  +G           G+      +E    V    +P T   T D 
Sbjct: 296 ETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAIPTTAASTPDA 355

Query: 318 VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQH 377
           VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQH
Sbjct: 356 VDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQH 415

Query: 378 FQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQAL 437
           FQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP  +   L
Sbjct: 416 FQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNML 475

Query: 438 RRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYV 497
           ++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP V
Sbjct: 476 KKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAV 535

Query: 498 AQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSEES 537
           A+EIQ+E+DELLQ+++       A+M          D    S++ET   V    V+ E S
Sbjct: 536 AEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFS 595

Query: 538 -EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVK 594
            +++ P+H F     PA  ENE   V  +      A+  +         N+  +E  +VK
Sbjct: 596 LDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISEVK 651

Query: 595 EMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYG 654
            M        G E   + +    ED   +  A+IGL+V  V IATVIVI+LVML+K+QY 
Sbjct: 652 -MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYT 710

Query: 655 TISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
           +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 711 SIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 750


>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
           sapiens]
          Length = 770

 Score =  640 bits (1652), Expect = 0.0
 Identities = 370/779 (47%), Positives = 478/779 (61%), Gaps = 113/779 (14%)

Query: 15  LLLLLLVGLTAPALALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDP 74
           L LLLL   TA AL +         NAG    +AEPQIAMFCG+LNMH+N+Q GKW+ DP
Sbjct: 5   LALLLLAAWTARALEVP-----TDGNAGL---LAEPQIAMFCGRLNMHMNVQNGKWDSDP 56

Query: 75  TGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFK 132
           +GTK+C +TKE +LQYCQE+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++
Sbjct: 57  SGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYR 116

Query: 133 CLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGV 192
           CLVGEFVSD LLVP+KC+F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+
Sbjct: 117 CLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI 176

Query: 193 DQFHGTEYVCCP---------------------------------QTKIIGSVSKEEEEE 219
           D+F G E+VCCP                                 + K++  V++EEE  
Sbjct: 177 DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVV-EVAEEEEVA 235

Query: 220 DEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVD---EDDEDEEEGEEVVED------ 270
           + EEEE +D+E+D D  + E   E   E+ TE             E  EEVV +      
Sbjct: 236 EVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQA 295

Query: 271 ---------RDYYYDTFKGD----------------DYNEENPTEPGSDGTMSDKEITHD 305
                      +Y+D  +G                 D  E      GS  + S  + T +
Sbjct: 296 ETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQE 355

Query: 306 ------VKVPPTPLPTND-VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEE 358
                 VK+P T   T D VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEE
Sbjct: 356 PLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEE 415

Query: 359 AELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALEN 418
           AE QAKNLPKA+++ +IQHFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALEN
Sbjct: 416 AERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALEN 475

Query: 419 YLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLH 478
           Y+ ALQ+ PPRP  +   L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL 
Sbjct: 476 YITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLR 535

Query: 479 VIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQR-------ADM----------DQFTA 521
           VI ER NQSLSLLY VP VA+EIQ+E+DELLQ+++       A+M          D    
Sbjct: 536 VIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMP 595

Query: 522 SISETPVDVR---VSSEES-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVI 575
           S++ET   V    V+ E S +++ P+H F     PA  ENE   V  +      A+  + 
Sbjct: 596 SLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLT 651

Query: 576 NSKNKVDENMVIDETLDVKEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAV 635
                   N+  +E  +VK M        G E   + +    ED   +  A+IGL+V  V
Sbjct: 652 TRPGSGLTNIKTEEISEVK-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGV 710

Query: 636 AIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
            IATVIVI+LVML+K+QY +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 711 VIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 769


>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
           sapiens]
          Length = 639

 Score =  582 bits (1499), Expect = e-166
 Identities = 317/631 (50%), Positives = 418/631 (66%), Gaps = 40/631 (6%)

Query: 93  EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
           E+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++CLVGEFVSD LLVP+KC+
Sbjct: 19  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78

Query: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCPQTKIIG 210
           F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+D+F G E+VCCP  +   
Sbjct: 79  FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138

Query: 211 SVSKEEEEEDEEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDE--DDEDEEEGEEV 267
           +V   + EED+ +      + DY D  + +    A+ E+  E   +E  DDED+E+G+EV
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEV 198

Query: 268 VEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTND-VDVYFETSA 326
            E+ +  Y+         E  T   +  T + + +   V+VP T   T D VD Y ET  
Sbjct: 199 EEEAEEPYEEAT------ERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPG 252

Query: 327 DDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALE 386
           D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQHFQ  V++LE
Sbjct: 253 DENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLE 312

Query: 387 KEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENK 446
           +EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP  +   L++YVRAE K
Sbjct: 313 QEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQK 372

Query: 447 DRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEID 506
           DR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP VA+EIQ+E+D
Sbjct: 373 DRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVD 432

Query: 507 ELLQEQR-------ADM----------DQFTASISETPVDVR---VSSEES-EEIPPFHP 545
           ELLQ+++       A+M          D    S++ET   V    V+ E S +++ P+H 
Sbjct: 433 ELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHS 492

Query: 546 F--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603
           F     PA  ENE   V  +      A+  +         N+  +E  +VK M       
Sbjct: 493 FGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISEVK-MDAEFRHD 547

Query: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEV 663
            G E   + +    ED   +  A+IGL+V  V IATVIVI+LVML+K+QY +I HG+VEV
Sbjct: 548 SGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEV 607

Query: 664 DPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
           D  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 608 DAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 638


>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
           sapiens]
          Length = 714

 Score =  556 bits (1432), Expect = e-158
 Identities = 325/701 (46%), Positives = 423/701 (60%), Gaps = 105/701 (14%)

Query: 93  EMYPELQITNVMEANQRVSIDNWCRRDKKQCKSR--FVTPFKCLVGEFVSDVLLVPEKCQ 150
           E+YPELQITNV+EANQ V+I NWC+R +KQCK+   FV P++CLVGEFVSD LLVP+KC+
Sbjct: 19  EVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCK 78

Query: 151 FFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPCGVDQFHGTEYVCCP------ 204
           F H+ERM+VCE H HWHTV KE C  +   L+ YGMLLPCG+D+F G E+VCCP      
Sbjct: 79  FLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESD 138

Query: 205 ---------------------------QTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYK 237
                                      + K++  V++EEE  + EEEE +D+E+D D  +
Sbjct: 139 NVDSADAEEDDSDVWWGGADTDYADGSEDKVV-EVAEEEEVAEVEEEEADDDEDDEDGDE 197

Query: 238 SEFPTEADLEDFTEAAVD---EDDEDEEEGEEVVED---------------RDYYYDTFK 279
            E   E   E+ TE             E  EEVV +                 +Y+D  +
Sbjct: 198 VEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTE 257

Query: 280 GD----------------DYNEENPTEPGSDGTMSDKEITHD------VKVPPTPLPTND 317
           G                 D  E      GS  + S  + T +      VK+P T   T D
Sbjct: 258 GKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPD 317

Query: 318 -VDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQ 376
            VD Y ET  D+NEHA FQKAKE+LE +HR RM +V +EWEEAE QAKNLPKA+++ +IQ
Sbjct: 318 AVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQ 377

Query: 377 HFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQA 436
           HFQ  V++LE+EAA+E+QQLVETH+ARVEAMLNDRRR+ALENY+ ALQ+ PPRP  +   
Sbjct: 378 HFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNM 437

Query: 437 LRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPY 496
           L++YVRAE KDR HT++H++HV  VDP+KAAQ++SQVMTHL VI ER NQSLSLLY VP 
Sbjct: 438 LKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPA 497

Query: 497 VAQEIQEEIDELLQEQR-------ADM----------DQFTASISETPVDVR---VSSEE 536
           VA+EIQ+E+DELLQ+++       A+M          D    S++ET   V    V+ E 
Sbjct: 498 VAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEF 557

Query: 537 S-EEIPPFHPF--HPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDV 593
           S +++ P+H F     PA  ENE   V  +      A+  +         N+  +E  +V
Sbjct: 558 SLDDLQPWHSFGADSVPANTENEVEPVDARP----AADRGLTTRPGSGLTNIKTEEISEV 613

Query: 594 KEMIFNAERVGGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVMLRKRQY 653
           K M        G E   + +    ED   +  A+IGL+V  V IATVIVI+LVML+K+QY
Sbjct: 614 K-MDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQY 672

Query: 654 GTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQ 694
            +I HG+VEVD  +TPEERHL+KMQ +GYENPTYK+ EQMQ
Sbjct: 673 TSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQ 713


>gi|4885065 amyloid precursor-like protein 1 isoform 2 precursor
           [Homo sapiens]
          Length = 650

 Score =  473 bits (1216), Expect = e-133
 Identities = 279/690 (40%), Positives = 389/690 (56%), Gaps = 77/690 (11%)

Query: 15  LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
           L LLLL+    PA+ +LAG       + G   A    Q+A  CG+L +H +++TG+WEPD
Sbjct: 24  LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77

Query: 74  PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
           P  ++ C    + VL+YC++MYPELQI  V +A Q + ++ WC   +   C      V P
Sbjct: 78  PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137

Query: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
           F+CL GEFVS+ LLVPE C+F H+ERM+ CE+    H   +EAC +QG+ L+  GMLLPC
Sbjct: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197

Query: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
           G D+F G EYVCC       P    +G  S          E  EDEEE+       FP  
Sbjct: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252

Query: 244 ADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEIT 303
            D                          DY+ +  + ++  EE    P S  T++     
Sbjct: 253 VD--------------------------DYFVEPPQAEE--EEETVPPPSSHTLAVVG-- 282

Query: 304 HDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363
              KV PTP PT+ VD+YF    + +EH  F +AK  LE R   +++ V +EW  A+ Q+
Sbjct: 283 ---KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQS 339

Query: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423
           KNLPKA+RQ L +HFQ++++ LE++ + E+Q+LVETH  RV A++ND+RR ALE +LAAL
Sbjct: 340 KNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL 399

Query: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483
           Q+DPP+  R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER
Sbjct: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459

Query: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543
            NQSL LL + P++AQE++ +I ELL  +     +      E P     S ++    PP 
Sbjct: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSEL-----EAPAPGGSSEDKGGLQPPD 514

Query: 544 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603
                   LP+    G  EQD            S  K   N +      V   +      
Sbjct: 515 SKDDTPMTLPK----GSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPF 560

Query: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVE 662
              E +R+ + P      +S  A+ GLL++     ++IV+S+++L RK+ YG ISHG+VE
Sbjct: 561 HSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVE 618

Query: 663 VDPMLTPEERHLNKMQNHGYENPTYKYLEQ 692
           VDPMLT EE+ L ++Q HGYENPTY++LE+
Sbjct: 619 VDPMLTLEEQQLRELQRHGYENPTYRFLEE 648


>gi|67782338 amyloid precursor-like protein 1 isoform 1 precursor
           [Homo sapiens]
          Length = 651

 Score =  472 bits (1214), Expect = e-133
 Identities = 279/690 (40%), Positives = 388/690 (56%), Gaps = 76/690 (11%)

Query: 15  LLLLLLVGLTAPAL-ALAGYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPD 73
           L LLLL+    PA+ +LAG       + G   A    Q+A  CG+L +H +++TG+WEPD
Sbjct: 24  LPLLLLLLRAQPAIGSLAG------GSPGAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPD 77

Query: 74  PTGTKSCFETKEEVLQYCQEMYPELQITNVMEANQRVSIDNWCRRDKK-QCKSRF--VTP 130
           P  ++ C    + VL+YC++MYPELQI  V +A Q + ++ WC   +   C      V P
Sbjct: 78  PQRSRRCLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERWCGGSRSGSCAHPHHQVVP 137

Query: 131 FKCLVGEFVSDVLLVPEKCQFFHKERMEVCENHQHWHTVVKEACLTQGMTLYSYGMLLPC 190
           F+CL GEFVS+ LLVPE C+F H+ERM+ CE+    H   +EAC +QG+ L+  GMLLPC
Sbjct: 138 FRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPC 197

Query: 191 GVDQFHGTEYVCC-------PQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTE 243
           G D+F G EYVCC       P    +G  S          E  EDEEE+       FP  
Sbjct: 198 GSDRFRGVEYVCCPPPGTPDPSGTAVGDPSTRSWPPGSRVEGAEDEEEE-----ESFPQP 252

Query: 244 ADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEIT 303
            D                          DY+ +  + ++  EE    P S  T++     
Sbjct: 253 VD--------------------------DYFVEPPQAEE--EEETVPPPSSHTLAVVG-- 282

Query: 304 HDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQA 363
              KV PTP PT+ VD+YF    + +EH  F +AK  LE R   +++ V +EW  A+ Q+
Sbjct: 283 ---KVTPTPRPTDGVDIYFGMPGEISEHEGFLRAKMDLEERRMRQINEVMREWAMADNQS 339

Query: 364 KNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAAL 423
           KNLPKA+RQ L +HFQ++++ LE++ + E+Q+LVETH  RV A++ND+RR ALE +LAAL
Sbjct: 340 KNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAAL 399

Query: 424 QSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEER 483
           Q+DPP+  R+L ALRRY+RAE K++ HT+RHYQHV AVDPEKA QM+ QV THL VIEER
Sbjct: 400 QADPPQAERVLLALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVHTHLQVIEER 459

Query: 484 RNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEEIPPF 543
            NQSL LL + P++AQE++ +I ELL  +     +  A           SSE+   + P 
Sbjct: 460 VNQSLGLLDQNPHLAQELRPQIQELLHSEHLGPSELEAPAPGG------SSEDKGGLQP- 512

Query: 544 HPFHPFPALPENEGSGVGEQDGGLIGAEEKVINSKNKVDENMVIDETLDVKEMIFNAERV 603
            P       P     G  EQD            S  K   N +      V   +      
Sbjct: 513 -PDSKDADTPMTLPKGSTEQDAA----------SPEKEKMNPLEQYERKVNASVPRGFPF 561

Query: 604 GGLEEERESVGPLREDFSLSSSALIGLLVIAVAIATVIVISLVML-RKRQYGTISHGIVE 662
              E +R+ + P      +S  A+ GLL++     ++IV+S+++L RK+ YG ISHG+VE
Sbjct: 562 HSSEIQRDELAP--AGTGVSREAVSGLLIMGAGGGSLIVLSMLLLRRKKPYGAISHGVVE 619

Query: 663 VDPMLTPEERHLNKMQNHGYENPTYKYLEQ 692
           VDPMLT EE+ L ++Q HGYENPTY++LE+
Sbjct: 620 VDPMLTLEEQQLRELQRHGYENPTYRFLEE 649


>gi|7662316 HIV-1 Vpr binding protein [Homo sapiens]
          Length = 1507

 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 33/94 (35%), Positives = 50/94 (53%), Gaps = 7/94 (7%)

Query: 215  EEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYY 274
            E+EEED+EEEE+E+E++D D   ++   E D +   EA ++EDD +E  GE+   D    
Sbjct: 1398 EDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDND---- 1453

Query: 275  YDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKV 308
               F   D    N  E G DG   D +   +V++
Sbjct: 1454 ---FSPSDEELANLLEEGEDGEDEDSDADEEVEL 1484



 Score = 35.0 bits (79), Expect = 0.23
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 28/98 (28%)

Query: 212  VSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE-- 269
            V ++   EDE+EEE+++EEE                        E+++D+E+ ++  +  
Sbjct: 1389 VGRQRLAEDEDEEEDQEEEEQ-----------------------EEEDDDEDDDDTDDLD 1425

Query: 270  --DRDYYYDTFKGDDYNEENPTEPG-SDGTMSDKEITH 304
              D D   +    +D N EN  E G +D + SD+E+ +
Sbjct: 1426 ELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELAN 1463


>gi|155030232 proline, glutamic acid and leucine rich protein 1
           [Homo sapiens]
          Length = 1130

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 40/109 (36%), Positives = 60/109 (55%), Gaps = 10/109 (9%)

Query: 209 IGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEE-- 266
           I S  +EEEEE+EEEEEEE+EEE+ + ++ E   E D E++ E   +E++E EEE EE  
Sbjct: 883 INSSDEEEEEEEEEEEEEEEEEEEEEDFEEE---EEDEEEYFEEEEEEEEEFEEEFEEEE 939

Query: 267 -VVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLP 314
             +E+ +   D  + ++  E    E G+ G     E+      PPT  P
Sbjct: 940 GELEEEEEEEDEEEEEELEEVEDLEFGTAG----GEVEEGAPPPPTLPP 984



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 42/122 (34%), Positives = 56/122 (45%), Gaps = 16/122 (13%)

Query: 208  IIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFT---------------EA 252
            I  S  +EEEEE+EEEEEEE+EEE+ D  + E   E   E+                 E 
Sbjct: 883  INSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGEL 942

Query: 253  AVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
              +E++EDEEE EE+ E  D  + T  G +  E  P  P     +   E    V+  P P
Sbjct: 943  EEEEEEEDEEEEEELEEVEDLEFGT-AGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEP 1001

Query: 313  LP 314
             P
Sbjct: 1002 EP 1003



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 29/99 (29%)

Query: 208 IIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEG-EE 266
           +I   S +EEEE+EEEEEEE+EEE                           E+EEE  EE
Sbjct: 880 VININSSDEEEEEEEEEEEEEEEE---------------------------EEEEEDFEE 912

Query: 267 VVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHD 305
             ED + Y++  + ++   E   E   +G + ++E   D
Sbjct: 913 EEEDEEEYFEEEEEEEEEFEEEFEE-EEGELEEEEEEED 950



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 15/49 (30%), Positives = 26/49 (53%)

Query: 242 TEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTE 290
           T  ++    E   +E++E+EEE EE  E+ D+  +    ++Y EE   E
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEE 927



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 15/44 (34%), Positives = 26/44 (59%)

Query: 243 EADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEE 286
           E DL      + DE++E+EEE EE  E+ +   + F+ ++ +EE
Sbjct: 875 EEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEE 918


>gi|87299628 biorientation of chromosomes in cell division 1-like
           [Homo sapiens]
          Length = 3051

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 67/310 (21%), Positives = 131/310 (42%), Gaps = 14/310 (4%)

Query: 207 KIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEE 266
           K + S+    E+   + +  E  +ED+ +  S+     D+   +    D    +E+  EE
Sbjct: 367 KEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEE 426

Query: 267 VVEDRDYYYDTFKGDD--YNEENPTEPGSDGTM--SDKEITHDVKVPPTPLPTNDVDVYF 322
           VV            DD   N++N T+  +  +     K + H     P        D   
Sbjct: 427 VVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDD 486

Query: 323 ETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMV 382
           E + +    +  ++ +E+L  R  NR    +K  ++AE    +  K + ++ +   ++  
Sbjct: 487 ELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESST 546

Query: 383 KALEKEAASEKQQLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVR 442
           K+LE +AA  K+ L E  +   +  L+ +R+    N     +          + L+    
Sbjct: 547 KSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEH 606

Query: 443 AENKDRLHTIRHYQHVLA-VDPEKAAQMKSQVMTHLHVIEERRNQS-LSLLYK----VPY 496
            E K+++ + +  +HV A  +P K A+  S+    LHV++E +N+S L   +K     P 
Sbjct: 607 CE-KEKISSSKELKHVHAKSEPSKPARRLSE---SLHVVDENKNESKLEREHKRRTSTPV 662

Query: 497 VAQEIQEEID 506
           + + +QEE D
Sbjct: 663 IMEGVQEETD 672



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 20/46 (43%), Positives = 27/46 (58%), Gaps = 5/46 (10%)

Query: 204  PQTKIIGSVS-----KEEEEEDEEEEEEEDEEEDYDVYKSEFPTEA 244
            P+ K   SVS     K+E+E DEEEEEEE++E      +S   +EA
Sbjct: 2966 PERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEA 3011



 Score = 29.6 bits (65), Expect = 9.8
 Identities = 17/61 (27%), Positives = 27/61 (44%)

Query: 205  QTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEG 264
            + KI+ SV +   +        +D E      K +      +ED  E   DE++E+EEE 
Sbjct: 2937 EEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEED 2996

Query: 265  E 265
            E
Sbjct: 2997 E 2997


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 39/139 (28%), Positives = 70/139 (50%), Gaps = 25/139 (17%)

Query: 210 GSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE 269
           G +S EEE+E+EEEEEEE+EE++ +  + E   E + E+  E   +E++E+EEE EE   
Sbjct: 253 GILSHEEEDEEEEEEEEEEEEDEEEEEEEE---EEEEEEEEEEEEEEEEEEEEEEEEAAP 309

Query: 270 DRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDN 329
           D  +  DT                  + +  +   +++ P +P P  +  V  E  +DD+
Sbjct: 310 DVIFQEDT------------------SHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDD 351

Query: 330 E----HARFQKAKEQLEIR 344
           +    H+R     ++ E++
Sbjct: 352 KDEDTHSRKSTVTDESEMQ 370


>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
          Length = 740

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%)

Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262
           CP      +  +++EE DEEEEEEE+EEE+      E   E DLE   E    EDDE+E+
Sbjct: 427 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 481

Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
           E EE    +D           + E   EPG   + S  E
Sbjct: 482 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 520



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 11/101 (10%)

Query: 210 GSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE 269
           G  S+        E ++ED+EE  +  + E   E + E+ T++  +ED E  +EG+E  E
Sbjct: 421 GMASQGCPSASRAETDDEDDEESDE--EEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE 478

Query: 270 DRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPP 310
           + D   +   G D         G    MS  +I+++  + P
Sbjct: 479 EEDEEEEAAAGKD---------GDKSPMSSLQISNEKNLEP 510


>gi|215422388 death-domain associated protein isoform a [Homo
           sapiens]
          Length = 740

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%)

Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262
           CP      +  +++EE DEEEEEEE+EEE+      E   E DLE   E    EDDE+E+
Sbjct: 427 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 481

Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
           E EE    +D           + E   EPG   + S  E
Sbjct: 482 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 520



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 11/101 (10%)

Query: 210 GSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE 269
           G  S+        E ++ED+EE  +  + E   E + E+ T++  +ED E  +EG+E  E
Sbjct: 421 GMASQGCPSASRAETDDEDDEESDE--EEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE 478

Query: 270 DRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPP 310
           + D   +   G D         G    MS  +I+++  + P
Sbjct: 479 EEDEEEEAAAGKD---------GDKSPMSSLQISNEKNLEP 510


>gi|215422366 death-domain associated protein isoform b [Homo
           sapiens]
          Length = 752

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 36/99 (36%), Positives = 47/99 (47%), Gaps = 5/99 (5%)

Query: 203 CPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEE 262
           CP      +  +++EE DEEEEEEE+EEE+      E   E DLE   E    EDDE+E+
Sbjct: 439 CPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEE---EEDLEQMQEG--QEDDEEED 493

Query: 263 EGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
           E EE    +D           + E   EPG   + S  E
Sbjct: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGE 532



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 11/101 (10%)

Query: 210 GSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE 269
           G  S+        E ++ED+EE  +  + E   E + E+ T++  +ED E  +EG+E  E
Sbjct: 433 GMASQGCPSASRAETDDEDDEESDE--EEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE 490

Query: 270 DRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPP 310
           + D   +   G D         G    MS  +I+++  + P
Sbjct: 491 EEDEEEEAAAGKD---------GDKSPMSSLQISNEKNLEP 522


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 77/343 (22%), Positives = 141/343 (41%), Gaps = 45/343 (13%)

Query: 216 EEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYY 275
           E E  E+EE+ E  +E Y++ ++E  T++  ++    A +   ED+E+ EE         
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEE--------- 193

Query: 276 DTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQ 335
                    EE P      G++ + ++   V+   T      V +  +     +E  + +
Sbjct: 194 --------EEEKPKR----GSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQE 241

Query: 336 KAKEQ--LEIRHRNRMDRVKKEWEEA-----ELQAKNLPKAERQTLIQHFQAMVKALEKE 388
           + +EQ   EI H  +M+   KE  EA     E + +   KAE+   I   +A ++A EK 
Sbjct: 242 EEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKA 301

Query: 389 AASEKQQLVETHLARV----EAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAE 444
           AA E+++       R+    +    +R+R+  E   AA +    +      A  R    E
Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361

Query: 445 NKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEE 504
            + R    R  Q   A + EKA   K +       +EE+++       K   V Q+I+  
Sbjct: 362 EEKRAAEER--QRARAEEEEKA---KVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIE-- 414

Query: 505 IDELLQEQRADMDQFTASI-----SETPVDVRVSSEESEEIPP 542
             + + E++A  D+   ++      E    V+   E+ +E  P
Sbjct: 415 -GKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKP 456



 Score = 33.5 bits (75), Expect = 0.68
 Identities = 48/247 (19%), Positives = 96/247 (38%), Gaps = 52/247 (21%)

Query: 210 GSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVE 269
           G +S EE +++EE E+  DE   ++  + E    A+ E     A + +    E+ +++ +
Sbjct: 231 GQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIAD 290

Query: 270 DRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDN 329
           +R                  E        ++E                        A++ 
Sbjct: 291 ER---------------ARIEAEEKAAAQERE---------------------RREAEER 314

Query: 330 EHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEA 389
           E  R      + E R      R+K+E + A  + + + + E++   +  +  +K  EK A
Sbjct: 315 ERMR------EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE--RQRIKEEEKRA 366

Query: 390 ASEKQ--QLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALR-RYV--RAE 444
           A E+Q  +  E   A+VE     +R   LE    A+Q    +  ++ Q +  ++V  +  
Sbjct: 367 AEERQRARAEEEEKAKVE---EQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA 423

Query: 445 NKDRLHT 451
            +D+L T
Sbjct: 424 QEDKLQT 430


>gi|94681063 bromodomain adjacent to zinc finger domain, 2B [Homo
           sapiens]
          Length = 2168

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 29/74 (39%), Positives = 52/74 (70%), Gaps = 3/74 (4%)

Query: 192 VDQFHGTEYVCCPQTKIIGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTE 251
           V+QF GT+    P +K     +++EEE+DEEE+EE+DE+++ D  +SE  ++++ E  TE
Sbjct: 588 VEQFRGTDSDI-PSSKDSEDSNEDEEEDDEEEDEEDDEDDESDDSQSE--SDSNSESDTE 644

Query: 252 AAVDEDDEDEEEGE 265
            + +EDD+D+++ E
Sbjct: 645 GSEEEDDDDKDQDE 658



 Score = 35.4 bits (80), Expect = 0.18
 Identities = 21/64 (32%), Positives = 34/64 (53%), Gaps = 4/64 (6%)

Query: 238 SEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTM 297
           S+ P+  D ED  E   +EDDE+E+E ++  ++ D   D+    D N E+ TE   +   
Sbjct: 596 SDIPSSKDSEDSNEDE-EEDDEEEDEEDDEDDESD---DSQSESDSNSESDTEGSEEEDD 651

Query: 298 SDKE 301
            DK+
Sbjct: 652 DDKD 655



 Score = 30.4 bits (67), Expect = 5.8
 Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 2/61 (3%)

Query: 209 IGSVSKEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVV 268
           I S   ++ EEDEEEE++  EE + D   SE  +EA  +   +  +    + + +G++  
Sbjct: 260 ISSSDSDDLEEDEEEEDQSIEESEDDDSDSE--SEAQHKSNNQVLLHGISDPKADGQKAT 317

Query: 269 E 269
           E
Sbjct: 318 E 318


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 275 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 334

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 335 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 386



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 67/350 (19%), Positives = 136/350 (38%), Gaps = 45/350 (12%)

Query: 214 KEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           K  +E  +E++  +++EE  ++ + +    +D  D    +++E +  +   E  + +  Y
Sbjct: 11  KTLDEILQEKKRRKEQEEKAEIKRLK---NSDDRDSKRDSLEEGELRDHCMEITIRNSPY 67

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
             +    D   E++         MS KE  H  K               E   +  +HAR
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD--------------EKRKEKWKHAR 113

Query: 334 FQKAKEQLEIRHRNRMDRVKKEWEEAELQ--AKNLPKAERQTLIQHFQAMVKALEKEAAS 391
            ++ + +   RHR   D+ ++EWE  + +  A+   + ER  L Q    + +  E+E   
Sbjct: 114 VKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ----LERKRERERKM 169

Query: 392 EKQQLVETHLARVEAMLNDRR-------------RMALENYLAALQS-----DPPRPHRI 433
            +QQ  +      E    +RR             R   E+Y   +++      PPRP R 
Sbjct: 170 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 229

Query: 434 LQAL---RRYVRAENKDRLHTIRHYQHVLAVDPE-KAAQMKSQVMTHLHVIEERRNQSLS 489
              L   R+ V+ E  +    +   Q +   + +  +A+  S         EE   +   
Sbjct: 230 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 289

Query: 490 LLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEE 539
                   ++E +EE +E  +E  ++ ++ +   +E   +  +S +E  E
Sbjct: 290 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 339



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 37/147 (25%), Positives = 60/147 (40%), Gaps = 32/147 (21%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTE------ADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           EE+ EE D   D  D+  SE  T       A+    +E   +E++E+EEEG    E  + 
Sbjct: 242 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE- 300

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
                  ++  EE   E GS+   + ++   +V                E  ++D E   
Sbjct: 301 ------EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE--- 337

Query: 334 FQKAKEQLEIRHRNRMDRVKKEWEEAE 360
            ++ +  L +   +R DR   E EEAE
Sbjct: 338 -RENENHLLVVPESRFDRDSGESEEAE 363


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 285 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 344

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 345 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 396



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 68/350 (19%), Positives = 138/350 (39%), Gaps = 35/350 (10%)

Query: 214 KEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           K  +E  +E++  +++EE  ++ + +    +D  D    +++E +  +   E  + +  Y
Sbjct: 11  KTLDEILQEKKRRKEQEEKAEIKRLK---NSDDRDSKRDSLEEGELRDHCMEITIRNSPY 67

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
             +    D   E++         MS KE  H  K             +   SA+  +HAR
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCR----HHSHSAEGGKHAR 123

Query: 334 FQKAKEQLEIRHRNRMDRVKKEWEEAELQ--AKNLPKAERQTLIQHFQAMVKALEKEAAS 391
            ++ + +   RHR   D+ ++EWE  + +  A+   + ER  L Q    + +  E+E   
Sbjct: 124 VKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ----LERKRERERKM 179

Query: 392 EKQQLVETHLARVEAMLNDRR-------------RMALENYLAALQS-----DPPRPHRI 433
            +QQ  +      E    +RR             R   E+Y   +++      PPRP R 
Sbjct: 180 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRE 239

Query: 434 LQAL---RRYVRAENKDRLHTIRHYQHVLAVDPE-KAAQMKSQVMTHLHVIEERRNQSLS 489
              L   R+ V+ E  +    +   Q +   + +  +A+  S         EE   +   
Sbjct: 240 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE 299

Query: 490 LLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEE 539
                   ++E +EE +E  +E  ++ ++ +   +E   +  +S +E  E
Sbjct: 300 EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349



 Score = 32.0 bits (71), Expect = 2.0
 Identities = 37/147 (25%), Positives = 60/147 (40%), Gaps = 32/147 (21%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTE------ADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           EE+ EE D   D  D+  SE  T       A+    +E   +E++E+EEEG    E  + 
Sbjct: 252 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE- 310

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
                  ++  EE   E GS+   + ++   +V                E  ++D E   
Sbjct: 311 ------EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE--- 347

Query: 334 FQKAKEQLEIRHRNRMDRVKKEWEEAE 360
            ++ +  L +   +R DR   E EEAE
Sbjct: 348 -RENENHLLVVPESRFDRDSGESEEAE 373


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 276 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 335

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 336 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 387



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 67/352 (19%), Positives = 137/352 (38%), Gaps = 48/352 (13%)

Query: 214 KEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           K  +E  +E++  +++EE  ++ + +    +D  D    +++E +  +   E  + +  Y
Sbjct: 11  KTLDEILQEKKRRKEQEEKAEIKRLK---NSDDRDSKRDSLEEGELRDHCMEITIRNSPY 67

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
             +    D   E++         MS KE  H  K               +    + +HAR
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRK---------------DEKRKEKKHAR 112

Query: 334 FQKAKEQLE--IRHRNRMDRVKKEWEEAELQ--AKNLPKAERQTLIQHFQAMVKALEKEA 389
            ++ + + E   RHR   D+ ++EWE  + +  A+   + ER  L Q    + +  E+E 
Sbjct: 113 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ----LERKRERER 168

Query: 390 ASEKQQLVETHLARVEAMLNDRR-------------RMALENYLAALQS-----DPPRPH 431
              +QQ  +      E    +RR             R   E+Y   +++      PPRP 
Sbjct: 169 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 228

Query: 432 RILQAL---RRYVRAENKDRLHTIRHYQHVLAVDPE-KAAQMKSQVMTHLHVIEERRNQS 487
           R    L   R+ V+ E  +    +   Q +   + +  +A+  S         EE   + 
Sbjct: 229 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 288

Query: 488 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEE 539
                     ++E +EE +E  +E  ++ ++ +   +E   +  +S +E  E
Sbjct: 289 EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 20/141 (14%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFK 279
           EE+ EE D   D  D+  SE  T +      E+    ++E+EEE EE  E+     ++ +
Sbjct: 243 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE-EEEEEEGSTSEESEE 301

Query: 280 GDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKE 339
            ++  EE   E GS+   + ++   +V                E  ++D E    ++ + 
Sbjct: 302 EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE----RENEN 343

Query: 340 QLEIRHRNRMDRVKKEWEEAE 360
            L +   +R DR   E EEAE
Sbjct: 344 HLLVVPESRFDRDSGESEEAE 364


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 285 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 344

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 345 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 396



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 65/357 (18%), Positives = 136/357 (38%), Gaps = 49/357 (13%)

Query: 214 KEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           K  +E  +E++  +++EE  ++ + +    +D  D    +++E +  +   E  + +  Y
Sbjct: 11  KTLDEILQEKKRRKEQEEKAEIKRLK---NSDDRDSKRDSLEEGELRDHCMEITIRNSPY 67

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
             +    D   E++         MS KE  H  K               +    + +HAR
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRK---------------DEKRKEKKHAR 112

Query: 334 FQKAKEQLEIR--HRNRMDRVKKEWEEAELQ--AKNLPKAERQT-----LIQHFQAMVKA 384
            ++ + + E R  HR   D+ ++EWE  + +  A+   + ER            + + + 
Sbjct: 113 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERK 172

Query: 385 LEKEAASEKQQLVETHLARVEAMLNDRR-------------RMALENYLAALQS-----D 426
            E+E    +QQ  +      E    +RR             R   E+Y   +++      
Sbjct: 173 RERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRS 232

Query: 427 PPRPHRILQAL---RRYVRAENKDRLHTIRHYQHVLAVDPE-KAAQMKSQVMTHLHVIEE 482
           PPRP R    L   R+ V+ E  +    +   Q +   + +  +A+  S         EE
Sbjct: 233 PPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEE 292

Query: 483 RRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEE 539
              +           ++E +EE +E  +E  ++ ++ +   +E   +  +S +E  E
Sbjct: 293 EEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 20/141 (14%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFK 279
           EE+ EE D   D  D+  SE  T +      E+    ++E+EEE EE  E+     ++ +
Sbjct: 252 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE-EEEEEEGSTSEESEE 310

Query: 280 GDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKE 339
            ++  EE   E GS+   + ++   +V                E  ++D E    ++ + 
Sbjct: 311 EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE----RENEN 352

Query: 340 QLEIRHRNRMDRVKKEWEEAE 360
            L +   +R DR   E EEAE
Sbjct: 353 HLLVVPESRFDRDSGESEEAE 373


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 253 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 312

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 313 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 364



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 64/324 (19%), Positives = 126/324 (38%), Gaps = 34/324 (10%)

Query: 242 TEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKE 301
           +++D  D    +++E +  +   E  + +  Y  +    D   E++         MS KE
Sbjct: 2   SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 61

Query: 302 ITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLE--IRHRNRMDRVKKEWEEA 359
             H  K         +   +   SA+  +HAR ++ + + E   RHR   D+ ++EWE  
Sbjct: 62  KVHHRKDEKR----KEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQ 117

Query: 360 ELQ--AKNLPKAERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRR----- 412
           + +  A+   + ER  L Q    + +  E+E    +QQ  +      E    +RR     
Sbjct: 118 KRREMAREHSRRERDRLEQ----LERKRERERKMREQQKEQREQKERERRAEERRKEREA 173

Query: 413 --------RMALENYLAALQS-----DPPRPHRILQAL---RRYVRAENKDRLHTIRHYQ 456
                   R   E+Y   +++      PPRP R    L   R+ V+ E  +    +   Q
Sbjct: 174 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 233

Query: 457 HVLAVDPE-KAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRAD 515
            +   + +  +A+  S         EE   +           ++E +EE +E  +E  ++
Sbjct: 234 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 293

Query: 516 MDQFTASISETPVDVRVSSEESEE 539
            ++ +   +E   +  +S +E  E
Sbjct: 294 SEEASEQSAEEVSEEEMSEDEERE 317



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 20/141 (14%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFK 279
           EE+ EE D   D  D+  SE  T +      E+    ++E+EEE EE  E+     ++ +
Sbjct: 220 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE-EEEEEEGSTSEESEE 278

Query: 280 GDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKE 339
            ++  EE   E GS+   + ++   +V                E  ++D E    ++ + 
Sbjct: 279 EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE----RENEN 320

Query: 340 QLEIRHRNRMDRVKKEWEEAE 360
            L +   +R DR   E EEAE
Sbjct: 321 HLLVVPESRFDRDSGESEEAE 341


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 242 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 301

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 302 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 353



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 61/311 (19%), Positives = 122/311 (39%), Gaps = 36/311 (11%)

Query: 256 EDDEDEEEGEEVVEDRDYYYD-TFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLP 314
           +D + + +  E  E RD+  + T +   Y  E+  E        +++ +  +K P     
Sbjct: 5   DDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMED-----RGEEDDSLAIKPPQQMSR 59

Query: 315 TNDVDVYFETSADDNEHARFQKAKEQLE--IRHRNRMDRVKKEWEEAELQ--AKNLPKAE 370
              V    +    + +HAR ++ + + E   RHR   D+ ++EWE  + +  A+   + E
Sbjct: 60  KEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119

Query: 371 RQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRR-------------RMALE 417
           R  L Q    + +  E+E    +QQ  +      E    +RR             R   E
Sbjct: 120 RDRLEQ----LERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE 175

Query: 418 NYLAALQS-----DPPRPHRILQAL---RRYVRAENKDRLHTIRHYQHVLAVDPE-KAAQ 468
           +Y   +++      PPRP R    L   R+ V+ E  +    +   Q +   + +  +A+
Sbjct: 176 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 235

Query: 469 MKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPV 528
             S         EE   +           ++E +EE +E  +E  ++ ++ +   +E   
Sbjct: 236 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 295

Query: 529 DVRVSSEESEE 539
           +  +S +E  E
Sbjct: 296 EEEMSEDEERE 306



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 20/141 (14%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFK 279
           EE+ EE D   D  D+  SE  T +      E+    ++E+EEE EE  E+     ++ +
Sbjct: 209 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE-EEEEEEGSTSEESEE 267

Query: 280 GDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKE 339
            ++  EE   E GS+   + ++   +V                E  ++D E    ++ + 
Sbjct: 268 EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE----RENEN 309

Query: 340 QLEIRHRNRMDRVKKEWEEAE 360
            L +   +R DR   E EEAE
Sbjct: 310 HLLVVPESRFDRDSGESEEAE 330


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 31  GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 90

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 91  DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 142



 Score = 32.3 bits (72), Expect = 1.5
 Identities = 34/137 (24%), Positives = 58/137 (42%), Gaps = 20/137 (14%)

Query: 225 EEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFKGDDY 283
           EE D   D  D+  SE  T +      E+    ++E+EEE EE  E+     ++ + ++ 
Sbjct: 2   EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE-EEEEEEGSTSEESEEEEEE 60

Query: 284 NEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEI 343
            EE   E GS+   + ++   +V                E  ++D E    ++ +  L +
Sbjct: 61  EEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE----RENENHLLV 102

Query: 344 RHRNRMDRVKKEWEEAE 360
              +R DR   E EEAE
Sbjct: 103 VPESRFDRDSGESEEAE 119


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 39/116 (33%), Positives = 52/116 (44%), Gaps = 17/116 (14%)

Query: 210 GSVSKEEEEEDEEEEEE-------------EDEEEDYDVYKSEFPTEADLEDFTEAAVDE 256
           GS S+EEEEE+EEEEEE             E+EEE+     SE  +E   E+ +E  + E
Sbjct: 287 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 346

Query: 257 DDEDEEEGEEVVEDRDYYYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTP 312
           D+E E E   +V         F  D    E   E   +GT     +T    VP +P
Sbjct: 347 DEERENENHLLVVPE----SRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP 398



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 69/352 (19%), Positives = 140/352 (39%), Gaps = 37/352 (10%)

Query: 214 KEEEEEDEEEEEEEDEEEDYDVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDY 273
           K  +E  +E++  +++EE  ++ + +    +D  D    +++E +  +   E  + +  Y
Sbjct: 11  KTLDEILQEKKRRKEQEEKAEIKRLK---NSDDRDSKRDSLEEGELRDHRMEITIRNSPY 67

Query: 274 YYDTFKGDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHAR 333
             +    D   E++         MS KE  H  K         +   +   SA+  +HAR
Sbjct: 68  RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKR----KEKRRHRSHSAEGGKHAR 123

Query: 334 FQKAKEQLE--IRHRNRMDRVKKEWEEAELQ--AKNLPKAERQTLIQHFQAMVKALEKEA 389
            ++ + + E   RHR   D+ ++EWE  + +  A+   + ER  L Q    + +  E+E 
Sbjct: 124 VKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ----LERKRERER 179

Query: 390 ASEKQQLVETHLARVEAMLNDRR-------------RMALENYLAALQS-----DPPRPH 431
              +QQ  +      E    +RR             R   E+Y   +++      PPRP 
Sbjct: 180 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 239

Query: 432 RILQAL---RRYVRAENKDRLHTIRHYQHVLAVDPE-KAAQMKSQVMTHLHVIEERRNQS 487
           R    L   R+ V+ E  +    +   Q +   + +  +A+  S         EE   + 
Sbjct: 240 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 299

Query: 488 LSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTASISETPVDVRVSSEESEE 539
                     ++E +EE +E  +E  ++ ++ +   +E   +  +S +E  E
Sbjct: 300 EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 351



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 20/141 (14%)

Query: 221 EEEEEEEDEEEDY-DVYKSEFPTEADLEDFTEAAVDEDDEDEEEGEEVVEDRDYYYDTFK 279
           EE+ EE D   D  D+  SE  T +      E+    ++E+EEE EE  E+     ++ +
Sbjct: 254 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE-EEEEEEGSTSEESEE 312

Query: 280 GDDYNEENPTEPGSDGTMSDKEITHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKE 339
            ++  EE   E GS+   + ++   +V                E  ++D E    ++ + 
Sbjct: 313 EEEEEEEEEEETGSNSEEASEQSAEEVSE--------------EEMSEDEE----RENEN 354

Query: 340 QLEIRHRNRMDRVKKEWEEAE 360
            L +   +R DR   E EEAE
Sbjct: 355 HLLVVPESRFDRDSGESEEAE 375


>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
          Length = 971

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 49/219 (22%), Positives = 102/219 (46%), Gaps = 21/219 (9%)

Query: 335 QKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQ 394
           Q + +QL+ +      R+ +E EE E Q +   K+ ++  +  FQ M +  EKE  + + 
Sbjct: 592 QTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN 651

Query: 395 QLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIR- 453
            L + H A +++ L D  R ++E +   ++ +       LQ LR  +  E K  L ++R 
Sbjct: 652 HLQQKHSAELQS-LKDAHRESMEGFRIEMEQE-------LQTLRFELEDEGKAMLASLRS 703

Query: 454 --HYQHVLAVD---PEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQ------ 502
             ++QH  A+D        ++ +  M     I+  R QS   + ++  + +E++      
Sbjct: 704 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 763

Query: 503 EEIDELLQEQRADMDQFTASISETPVDV-RVSSEESEEI 540
            E+D+ +Q    ++   T  +     ++ R+ SE +++I
Sbjct: 764 SELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQI 802


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 49/219 (22%), Positives = 102/219 (46%), Gaps = 21/219 (9%)

Query: 335 QKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKAERQTLIQHFQAMVKALEKEAASEKQ 394
           Q + +QL+ +      R+ +E EE E Q +   K+ ++  +  FQ M +  EKE  + + 
Sbjct: 712 QTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALEN 771

Query: 395 QLVETHLARVEAMLNDRRRMALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIR- 453
            L + H A +++ L D  R ++E +   ++ +       LQ LR  +  E K  L ++R 
Sbjct: 772 HLQQKHSAELQS-LKDAHRESMEGFRIEMEQE-------LQTLRFELEDEGKAMLASLRS 823

Query: 454 --HYQHVLAVD---PEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQ------ 502
             ++QH  A+D        ++ +  M     I+  R QS   + ++  + +E++      
Sbjct: 824 ELNHQHAAAIDLLRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHI 883

Query: 503 EEIDELLQEQRADMDQFTASISETPVDV-RVSSEESEEI 540
            E+D+ +Q    ++   T  +     ++ R+ SE +++I
Sbjct: 884 SELDKEVQHLHENISALTKELEFKGKEILRIRSESNQQI 922


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,994,809
Number of Sequences: 37866
Number of extensions: 1427844
Number of successful extensions: 30820
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 562
Number of HSP's successfully gapped in prelim test: 504
Number of HSP's that attempted gapping in prelim test: 11983
Number of HSP's gapped (non-prelim): 8074
length of query: 695
length of database: 18,247,518
effective HSP length: 109
effective length of query: 586
effective length of database: 14,120,124
effective search space: 8274392664
effective search space used: 8274392664
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.