Guide to the Human Genome
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Name: APP Sequence: fasta or formatted (639aa) NCBI GI: 209915570
Description:

amyloid beta A4 protein isoform e precursor

Referenced in:

Ankyrin Family
Additional Brain Proteins
PDZ Domain

Other entries for this name:
alt prot [714aa] amyloid beta A4 protein isoform f precursor
alt prot [751aa] amyloid beta A4 protein isoform b precursor
alt prot [695aa] amyloid beta A4 protein isoform c precursor
alt prot [770aa] amyloid beta A4 protein isoform a precursor
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.5         54           2
 C cysteine            1.4          9           2
 D aspartate           6.7         43           3
 E glutamate          12.8         82           4
 F phenylalanine       2.5         16           2
 G glycine             3.9         25           2
 H histidine           3.8         24           2
 I isoleucine          3.1         20           2
 K lysine              5.5         35           3
 L leucine             7.5         48           4
 M methionine          2.8         18           1
 N asparagine          3.8         24           1
 P proline             4.4         28           2
 Q glutamine           4.5         29           2
 R arginine            5.0         32           3
 S serine              4.4         28           1
 T threonine           6.4         41           7
 V valine              9.4         60           2
 W tryptophan          1.1          7           2
 Y tyrosine            2.5         16           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   amyloid beta A4 protein isoform e precursor 
APP                   0.974   amyloid beta A4 protein isoform c precursor 
APP                   0.921   amyloid beta A4 protein isoform b precursor 
APP                   0.903   amyloid beta A4 protein isoform f precursor 
APP                   0.876   amyloid beta A4 protein isoform a precursor 
APLP2                 0.441   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP2                 0.418   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP2                 0.417   amyloid beta (A4) precursor-like protein 2 isoform 1 ...
APLP1                 0.293   amyloid precursor-like protein 1 isoform 1 precursor...
APLP1                 0.291   amyloid precursor-like protein 1 isoform 2 precursor ...
APLP2                 0.284   amyloid beta (A4) precursor-like protein 2 isoform ...
MYT1                  0.027   myelin transcription factor 1 
MYT1L                 0.025   myelin transcription factor 1-like 
NCL                   0.023   nucleolin 
EIF5B                 0.023   eukaryotic translation initiation factor 5B 
SETD1B                0.022   SET domain containing 1B 
TNNT2                 0.021   troponin T type 2, cardiac isoform 1 
NOM1                  0.021   nucleolar protein with MIF4G domain 1 
BOD1L                 0.021   biorientation of chromosomes in cell division 1-like...
CNGB1                 0.020   cyclic nucleotide gated channel beta 1 isoform a [H...
TNNT2                 0.020   troponin T type 2, cardiac isoform 4 
CALR                  0.020   calreticulin precursor 
ANP32B                0.020   acidic (leucine-rich) nuclear phosphoprotein 32 famil...
KIF21A                0.019   kinesin family member 21A 
NEFL                  0.018   neurofilament, light polypeptide 68kDa 
LOC647020             0.018   PREDICTED: similar to acidic (leucine-rich) nuclear...
LOC647020             0.018   PREDICTED: similar to acidic (leucine-rich) nuclear...
YTHDC1                0.018   splicing factor YT521-B isoform 2 
YTHDC1                0.018   splicing factor YT521-B isoform 1 
UBTF                  0.017   upstream binding transcription factor, RNA polymera...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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