Guide to the Human Genome
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Name: APP Sequence: fasta or formatted (770aa) NCBI GI: 4502167
Description:

amyloid beta A4 protein isoform a precursor

Referenced in:

Ankyrin Family
Additional Brain Proteins
PDZ Domain

Other entries for this name:
alt prot [639aa] amyloid beta A4 protein isoform e precursor
alt prot [714aa] amyloid beta A4 protein isoform f precursor
alt prot [751aa] amyloid beta A4 protein isoform b precursor
alt prot [695aa] amyloid beta A4 protein isoform c precursor
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.2         63           2
 C cysteine            2.3         18           2
 D aspartate           6.5         50           3
 E glutamate          11.9         92           4
 F phenylalanine       2.7         21           2
 G glycine             4.9         38           2
 H histidine           3.2         25           2
 I isoleucine          3.1         24           2
 K lysine              5.3         41           3
 L leucine             7.3         56           4
 M methionine          3.1         24           1
 N asparagine          4.0         31           2
 P proline             4.5         35           2
 Q glutamine           4.7         36           2
 R arginine            4.8         37           3
 S serine              4.5         35           1
 T threonine           6.5         50           7
 V valine              8.4         65           2
 W tryptophan          1.2          9           2
 Y tyrosine            2.6         20           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   amyloid beta A4 protein isoform a precursor 
APP                   0.969   amyloid beta A4 protein isoform b precursor 
APP                   0.901   amyloid beta A4 protein isoform f precursor 
APP                   0.816   amyloid beta A4 protein isoform c precursor 
APP                   0.717   amyloid beta A4 protein isoform e precursor 
APLP2                 0.468   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP2                 0.466   amyloid beta (A4) precursor-like protein 2 isoform 1 ...
APLP2                 0.399   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP2                 0.232   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP1                 0.150   amyloid precursor-like protein 1 isoform 1 precursor...
APLP1                 0.149   amyloid precursor-like protein 1 isoform 2 precursor ...
SPINT2                0.030   serine protease inhibitor, Kunitz type, 2 
COL6A3                0.027   alpha 3 type VI collagen isoform 5 precursor 
COL6A3                0.027   alpha 3 type VI collagen isoform 1 precursor 
COL6A3                0.027   alpha 3 type VI collagen isoform 4 precursor 
SPINT3                0.027   serine protease inhibitor, Kunitz type, 3 
SPINT1                0.027   serine peptidase inhibitor, Kunitz type 1 isoform 2 ...
SPINT1                0.027   serine peptidase inhibitor, Kunitz type 1 isoform 2 p...
TFPI                  0.026   tissue factor pathway inhibitor isoform b precursor ...
TFPI                  0.026   tissue factor pathway inhibitor isoform a precursor [...
SPINT1                0.025   serine peptidase inhibitor, Kunitz type 1 isoform 1 ...
COL28A1               0.025   collagen, type XXVIII precursor 
SPINLW1               0.024   serine peptidase inhibitor-like, with Kunitz and WAP...
SPINLW1               0.024   serine peptidase inhibitor-like, with Kunitz and WAP...
COL7A1                0.023   alpha 1 type VII collagen precursor 
AMBP                  0.023   alpha-1-microglobulin/bikunin preproprotein 
TFPI2                 0.022   tissue factor pathway inhibitor 2 
WFIKKN2               0.022   WFIKKN2 protein 
PAPLN                 0.021   papilin 
MYT1L                 0.021   myelin transcription factor 1-like 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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