Guide to the Human Genome
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Name: APP Sequence: fasta or formatted (695aa) NCBI GI: 41406057
Description:

amyloid beta A4 protein isoform c precursor

Referenced in:

Ankyrin Family
Additional Brain Proteins
PDZ Domain

Other entries for this name:
alt prot [639aa] amyloid beta A4 protein isoform e precursor
alt prot [714aa] amyloid beta A4 protein isoform f precursor
alt prot [751aa] amyloid beta A4 protein isoform b precursor
alt prot [770aa] amyloid beta A4 protein isoform a precursor
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.2         57           2
 C cysteine            1.7         12           2
 D aspartate           6.8         47           3
 E glutamate          12.2         85           4
 F phenylalanine       2.4         17           2
 G glycine             4.5         31           2
 H histidine           3.6         25           2
 I isoleucine          3.3         23           2
 K lysine              5.5         38           3
 L leucine             7.5         52           4
 M methionine          3.0         21           1
 N asparagine          4.0         28           1
 P proline             4.5         31           2
 Q glutamine           4.7         33           2
 R arginine            4.7         33           3
 S serine              4.3         30           1
 T threonine           6.5         45           7
 V valine              8.9         62           2
 W tryptophan          1.2          8           2
 Y tyrosine            2.4         17           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   amyloid beta A4 protein isoform c precursor 
APP                   0.952   amyloid beta A4 protein isoform b precursor 
APP                   0.910   amyloid beta A4 protein isoform a precursor 
APP                   0.889   amyloid beta A4 protein isoform e precursor 
APP                   0.800   amyloid beta A4 protein isoform f precursor 
APLP2                 0.464   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP2                 0.444   amyloid beta (A4) precursor-like protein 2 isoform ...
APLP2                 0.442   amyloid beta (A4) precursor-like protein 2 isoform 1 ...
APLP1                 0.304   amyloid precursor-like protein 1 isoform 1 precursor...
APLP1                 0.302   amyloid precursor-like protein 1 isoform 2 precursor ...
APLP2                 0.259   amyloid beta (A4) precursor-like protein 2 isoform ...
MYT1                  0.025   myelin transcription factor 1 
MYT1L                 0.023   myelin transcription factor 1-like 
NCL                   0.021   nucleolin 
EIF5B                 0.021   eukaryotic translation initiation factor 5B 
SETD1B                0.020   SET domain containing 1B 
TNNT2                 0.020   troponin T type 2, cardiac isoform 1 
NOM1                  0.019   nucleolar protein with MIF4G domain 1 
BOD1L                 0.019   biorientation of chromosomes in cell division 1-like...
CNGB1                 0.018   cyclic nucleotide gated channel beta 1 isoform a [H...
TNNT2                 0.018   troponin T type 2, cardiac isoform 4 
CALR                  0.018   calreticulin precursor 
ANP32B                0.018   acidic (leucine-rich) nuclear phosphoprotein 32 famil...
KIF21A                0.017   kinesin family member 21A 
NEFL                  0.017   neurofilament, light polypeptide 68kDa 
LOC647020             0.017   PREDICTED: similar to acidic (leucine-rich) nuclear...
LOC647020             0.017   PREDICTED: similar to acidic (leucine-rich) nuclear...
YTHDC1                0.017   splicing factor YT521-B isoform 2 
YTHDC1                0.017   splicing factor YT521-B isoform 1 
UBTF                  0.016   upstream binding transcription factor, RNA polymera...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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