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Search of human proteins with 21389483
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
(825 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 1665 0.0
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s... 142 2e-33
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa... 142 2e-33
gi|5901898 leucine rich repeat containing 23 isoform b [Homo sap... 110 4e-24
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 102 1e-21
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap... 94 5e-19
gi|226874833 guanylate kinase 1 isoform b [Homo sapiens] 92 1e-18
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens] 92 1e-18
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens] 92 1e-18
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 91 4e-18
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s... 86 2e-16
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s... 86 2e-16
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s... 86 2e-16
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s... 86 2e-16
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 77 7e-14
gi|157674358 leucine rich repeat containing 50 [Homo sapiens] 71 5e-12
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 69 1e-11
gi|66472382 nischarin [Homo sapiens] 69 2e-11
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 68 4e-11
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 68 4e-11
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 67 5e-11
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 67 5e-11
gi|239752518 PREDICTED: similar to leucine rich repeat containin... 67 5e-11
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 67 5e-11
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 67 5e-11
gi|31621309 leucine rich repeat containing 6 [Homo sapiens] 67 9e-11
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 66 1e-10
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 66 1e-10
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 66 1e-10
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 66 1e-10
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 1665 bits (4311), Expect = 0.0
Identities = 825/825 (100%), Positives = 825/825 (100%)
Query: 1 MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSY 60
MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSY
Sbjct: 1 MATSERALLRTRAASLLRGLGRSRTGARSLQFRAEKERQPCWSFPMGQKTKGSSNIASSY 60
Query: 61 LLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGR 120
LLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGR
Sbjct: 61 LLQQLMHRYQELDSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGR 120
Query: 121 SGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQ 180
SGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQ
Sbjct: 121 SGSGTEQVYLNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQ 180
Query: 181 NNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLI 240
NNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLI
Sbjct: 181 NNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLI 240
Query: 241 HLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN 300
HLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN
Sbjct: 241 HLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN 300
Query: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD
Sbjct: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
Query: 361 QKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILA 420
QKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILA
Sbjct: 361 QKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQPQRIFDSTLPSLDAPYPMLILA 420
Query: 421 GPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKF 480
GPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKF
Sbjct: 421 GPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKF 480
Query: 481 ILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKY 540
ILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKY
Sbjct: 481 ILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKY 540
Query: 541 EGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYL 600
EGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYL
Sbjct: 541 EGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYL 600
Query: 601 GLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTP 660
GLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTP
Sbjct: 601 GLTEEPAKSLATTADVKTSHLKPEAHPTKYISSNMGDFLHSTDRNYLIKFWAKLSAKKTP 660
Query: 661 AERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCED 720
AERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCED
Sbjct: 661 AERDSIHRQHEAARQALMGRIRPDHTLLFQRGPVPAPLTSGLHYYTTLEELWKSFDLCED 720
Query: 721 YFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEET 780
YFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEET
Sbjct: 721 YFKPPFGPYPEKSGKDSLVSMKCSLFRFCPWSKELPFQPPEGSISSHLGSGASDSETEET 780
Query: 781 RKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR 825
RKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR
Sbjct: 781 RKALPIQSFSHEKESHQHRQHSVPVISRPGSNVKPTLPPIPQGRR 825
>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 142 bits (357), Expect = 2e-33
Identities = 99/303 (32%), Positives = 163/303 (53%), Gaps = 6/303 (1%)
Query: 73 DSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGRSGSGTEQVYLNL 132
DS+ +ED+ E E G + E E EE L E+ + + L L ++G+G Y+ L
Sbjct: 16 DSEKEEDEKETEEGEDYRKEGEEFP-EEWLPTPLTEDMMKEGLSLLCKTGNGLAHAYVKL 74
Query: 133 TLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPP 192
+ +L D+ +L Y+HL+ +D+S N + DLS ++ + +LL L A N L + + P
Sbjct: 75 EVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELP 134
Query: 193 KNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGL--EMCNNLIHLSLANNKIT 250
L+ A F++NQI++ +S + L L L GN I ++GL E +L + L N++
Sbjct: 135 -YLQIASFAYNQITDTEGIS-HPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLE 192
Query: 251 TINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENH-DLLEVINL 309
+ G+N +K L L+ N ++ + GLEDL L L L NQI +L G L+ +NL
Sbjct: 193 STLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNL 252
Query: 310 EDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEK 369
N +A L E+ +++LP LR L LL+NP +++ Y + + L LD++ + EE+
Sbjct: 253 RGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEER 312
Query: 370 VSA 372
A
Sbjct: 313 AEA 315
>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 142 bits (357), Expect = 2e-33
Identities = 99/303 (32%), Positives = 163/303 (53%), Gaps = 6/303 (1%)
Query: 73 DSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGRSGSGTEQVYLNL 132
DS+ +ED+ E E G + E E EE L E+ + + L L ++G+G Y+ L
Sbjct: 16 DSEKEEDEKETEEGEDYRKEGEEFP-EEWLPTPLTEDMMKEGLSLLCKTGNGLAHAYVKL 74
Query: 133 TLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPP 192
+ +L D+ +L Y+HL+ +D+S N + DLS ++ + +LL L A N L + + P
Sbjct: 75 EVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELP 134
Query: 193 KNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGL--EMCNNLIHLSLANNKIT 250
L+ A F++NQI++ +S + L L L GN I ++GL E +L + L N++
Sbjct: 135 -YLQIASFAYNQITDTEGIS-HPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLE 192
Query: 251 TINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENH-DLLEVINL 309
+ G+N +K L L+ N ++ + GLEDL L L L NQI +L G L+ +NL
Sbjct: 193 STLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNL 252
Query: 310 EDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEK 369
N +A L E+ +++LP LR L LL+NP +++ Y + + L LD++ + EE+
Sbjct: 253 RGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEER 312
Query: 370 VSA 372
A
Sbjct: 313 AEA 315
>gi|5901898 leucine rich repeat containing 23 isoform b [Homo
sapiens]
Length = 312
Score = 110 bits (276), Expect = 4e-24
Identities = 81/249 (32%), Positives = 131/249 (52%), Gaps = 6/249 (2%)
Query: 73 DSDGDEDQGEGEAGSEESSESEMLNLEEEFDGVLREEAVAKALHHLGRSGSGTEQVYLNL 132
DS+ +ED+ E E G + E E EE L E+ + + L L ++G+G Y+ L
Sbjct: 16 DSEKEEDEKETEEGEDYRKEGEEFP-EEWLPTPLTEDMMKEGLSLLCKTGNGLAHAYVKL 74
Query: 133 TLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPP 192
+ +L D+ +L Y+HL+ +D+S N + DLS ++ + +LL L A N L + + P
Sbjct: 75 EVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELP 134
Query: 193 KNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISGL--EMCNNLIHLSLANNKIT 250
L+ A F++NQI++ +S + L L L GN I ++GL E +L + L N++
Sbjct: 135 -YLQIASFAYNQITDTEGIS-HPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLE 192
Query: 251 TINGLNKLPIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENH-DLLEVINL 309
+ G+N +K L L+ N ++ + GLEDL L L L NQI +L G L+ +NL
Sbjct: 193 STLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNL 252
Query: 310 EDNKIAELR 318
+K R
Sbjct: 253 RRSKTLAFR 261
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 102 bits (254), Expect = 1e-21
Identities = 76/258 (29%), Positives = 127/258 (49%), Gaps = 4/258 (1%)
Query: 116 HHLGRSGSGTEQVYLNL---TLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPY 172
H L R+ S + ++NL +LS ++ S ++ +L L K+ ++ +
Sbjct: 54 HDLERNYSSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDH 113
Query: 173 LLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG 232
L LN N +T N + L D NQI EI LS L L+L N I++IS
Sbjct: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISN 173
Query: 233 LEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQ 291
LE +L L L N+IT I +N L +++L L+ N + + L L +L L+L HNQ
Sbjct: 174 LENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQ 233
Query: 292 ISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIF 351
I+ ++ ++N L+ + L N I+ + + + L + NPI ++S Y V+
Sbjct: 234 ITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQ 293
Query: 352 MLLRLTELDQKKIKVEEK 369
+++L +LD K+I EE+
Sbjct: 294 NMMQLRQLDMKRITEEER 311
Score = 30.0 bits (66), Expect = 9.1
Identities = 30/128 (23%), Positives = 55/128 (42%), Gaps = 3/128 (2%)
Query: 265 LSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIK 324
LS+ I + E + L L +++ + D L ++N + N I I+ I
Sbjct: 75 LSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITR---IQNIS 131
Query: 325 NLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVA 384
NL L L+L +N I+E S +L L + KKI E + +++ D +
Sbjct: 132 NLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQIT 191
Query: 385 AQDHLTHV 392
+++ H+
Sbjct: 192 KIENINHL 199
>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
Length = 360
Score = 94.0 bits (232), Expect = 5e-19
Identities = 68/233 (29%), Positives = 114/233 (48%), Gaps = 23/233 (9%)
Query: 151 LQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICD 210
L++LDL N+I+ + + + L L+ S N L LKK +N+IS+I +
Sbjct: 122 LRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN 181
Query: 211 LSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLP-IKILCLSNNQ 269
LS H L L L N I I ++ NL L L NKIT + L+ L + +L + +N+
Sbjct: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNR 241
Query: 270 IEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEY------- 322
+ I GL++L L+ L LSHN I ++GLEN++ L ++++ N+I ++ I +
Sbjct: 242 LTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEF 301
Query: 323 ---------------IKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
+K L + L NP+Q+ +Y V+ L + ++D
Sbjct: 302 WMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354
Score = 56.2 bits (134), Expect = 1e-07
Identities = 43/137 (31%), Positives = 69/137 (50%), Gaps = 7/137 (5%)
Query: 242 LSLANNKITTINGLNKLP-IKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN 300
+ L + +I I G L +K LCL N I+ I LE+L++L+ LDL NQI ++ LE
Sbjct: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
Query: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
LE++++ N LR IE + L L+ L L+ N I S+ L++ EL
Sbjct: 141 LTELEILDISFNL---LRNIEGVDKLTRLKKLFLVNNKI---SKIENLSNLHQLQMLELG 194
Query: 361 QKKIKVEEKVSAVNKYD 377
+I+ E + + +
Sbjct: 195 SNRIRAIENIDTLTNLE 211
Score = 47.0 bits (110), Expect = 7e-05
Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 23/148 (15%)
Query: 150 HLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEIC 209
+L+ L L NKI L + + L L+ N LT + NL++ SH
Sbjct: 209 NLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSH------- 261
Query: 210 DLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNN 268
N IE I GLE N L L +A+N+I I ++ L ++ +++N
Sbjct: 262 ---------------NGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDN 306
Query: 269 QIEMITGLEDLKALQNLDLSHNQISSLQ 296
+E + L++LK ++L+ + + + LQ
Sbjct: 307 LLESWSDLDELKGARSLETVYLERNPLQ 334
>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 92.4 bits (228), Expect = 1e-18
Identities = 56/191 (29%), Positives = 96/191 (50%), Gaps = 6/191 (3%)
Query: 410 LDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQD 469
+ P P+ +L+GP GK L RL ++ S F + HTTR P GE + DY+F++++
Sbjct: 1 MSGPRPV-VLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTRE 59
Query: 470 VFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRY 529
V + G FI + + YG ++ V+ + + ++++GVR++K + P Y
Sbjct: 60 VMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIY 119
Query: 530 ILVVPMNKEKYEGYLRRKGLFSRAEI--EFAVSRVDLYIKINQNFPGYFDEVINADDLDV 587
I V P + E LR++ + + A ++ D+ + PG FD VI D LD
Sbjct: 120 ISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADME---SSKEPGLFDVVIINDSLDQ 176
Query: 588 AYQKLSQLIRE 598
AY +L + + E
Sbjct: 177 AYAELKEALSE 187
>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
Length = 218
Score = 92.4 bits (228), Expect = 1e-18
Identities = 56/191 (29%), Positives = 96/191 (50%), Gaps = 6/191 (3%)
Query: 410 LDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQD 469
+ P P+ +L+GP GK L RL ++ S F + HTTR P GE + DY+F++++
Sbjct: 22 MSGPRPV-VLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTRE 80
Query: 470 VFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRY 529
V + G FI + + YG ++ V+ + + ++++GVR++K + P Y
Sbjct: 81 VMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIY 140
Query: 530 ILVVPMNKEKYEGYLRRKGLFSRAEI--EFAVSRVDLYIKINQNFPGYFDEVINADDLDV 587
I V P + E LR++ + + A ++ D+ + PG FD VI D LD
Sbjct: 141 ISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADME---SSKEPGLFDVVIINDSLDQ 197
Query: 588 AYQKLSQLIRE 598
AY +L + + E
Sbjct: 198 AYAELKEALSE 208
>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 92.4 bits (228), Expect = 1e-18
Identities = 56/191 (29%), Positives = 96/191 (50%), Gaps = 6/191 (3%)
Query: 410 LDAPYPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQD 469
+ P P+ +L+GP GK L RL ++ S F + HTTR P GE + DY+F++++
Sbjct: 1 MSGPRPV-VLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTRE 59
Query: 470 VFDEMVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRY 529
V + G FI + + YG ++ V+ + + ++++GVR++K + P Y
Sbjct: 60 VMQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIY 119
Query: 530 ILVVPMNKEKYEGYLRRKGLFSRAEI--EFAVSRVDLYIKINQNFPGYFDEVINADDLDV 587
I V P + E LR++ + + A ++ D+ + PG FD VI D LD
Sbjct: 120 ISVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADME---SSKEPGLFDVVIINDSLDQ 176
Query: 588 AYQKLSQLIRE 598
AY +L + + E
Sbjct: 177 AYAELKEALSE 187
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 90.9 bits (224), Expect = 4e-18
Identities = 55/182 (30%), Positives = 91/182 (50%), Gaps = 2/182 (1%)
Query: 417 LILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVN 476
+IL GP+ CG+ EL RL + F HTTR E DYHF+S+ F+ +
Sbjct: 482 IILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIA 541
Query: 477 MGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMN 536
GKFI + + YG + D+V + G + + + +++L+ S +P I + P +
Sbjct: 542 AGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPS 601
Query: 537 KEKYEGYLRRKGLFSRAEIEFAVSRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLI 596
+E+ L ++G + E + ++ ++ QN YFD I DLD AYQ+L +LI
Sbjct: 602 QERLRALLAKEGKNPKPEELREI--IEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLI 659
Query: 597 RE 598
+
Sbjct: 660 NK 661
>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/183 (34%), Positives = 90/183 (49%), Gaps = 1/183 (0%)
Query: 220 LILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKI-LCLSNNQIEMITGLED 278
L LD I I L NL L L NN I I GL L + L LS N IE I GL+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 279 LKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENP 338
L L++L L +N+IS + L+ L+V++L +N+I + I Y++ LR L+L NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 339 IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQ 398
I E +Y F+ L L LD ++I K A K+ + + Q++L Q
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQ 227
Query: 399 PQR 401
QR
Sbjct: 228 AQR 230
Score = 60.5 bits (145), Expect = 6e-09
Identities = 51/153 (33%), Positives = 73/153 (47%), Gaps = 7/153 (4%)
Query: 173 LLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG 232
+L L N+ N +NL+K +N I +I L L L L N IE I G
Sbjct: 45 VLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEG 104
Query: 233 LEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIE---MITGLEDLKALQNLDLS 288
L+ NL LSL NN+I+ I+ L+ L +++L L NN+I+ I L K L+ L LS
Sbjct: 105 LDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 289 HNQISSLQGLENHDLLEVINLEDNKIAELREIE 321
N IS E++ + L D + R I+
Sbjct: 165 RNPISE---AEDYKMFICAYLPDLMYLDYRRID 194
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 130 LNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNF 189
L+L L N++ + L + +L+KL L N IE + + + +L+ L+ S NN+ T
Sbjct: 46 LSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 190 KPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG---LEMCNNLIHLSLAN 246
NL+ +N+IS+I L A L L L N I+ + L L LSL+
Sbjct: 106 DTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSR 165
Query: 247 NKIT 250
N I+
Sbjct: 166 NPIS 169
>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/183 (34%), Positives = 90/183 (49%), Gaps = 1/183 (0%)
Query: 220 LILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKI-LCLSNNQIEMITGLED 278
L LD I I L NL L L NN I I GL L + L LS N IE I GL+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 279 LKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENP 338
L L++L L +N+IS + L+ L+V++L +N+I + I Y++ LR L+L NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 339 IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQ 398
I E +Y F+ L L LD ++I K A K+ + + Q++L Q
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQ 227
Query: 399 PQR 401
QR
Sbjct: 228 AQR 230
Score = 60.5 bits (145), Expect = 6e-09
Identities = 51/153 (33%), Positives = 73/153 (47%), Gaps = 7/153 (4%)
Query: 173 LLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG 232
+L L N+ N +NL+K +N I +I L L L L N IE I G
Sbjct: 45 VLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEG 104
Query: 233 LEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIE---MITGLEDLKALQNLDLS 288
L+ NL LSL NN+I+ I+ L+ L +++L L NN+I+ I L K L+ L LS
Sbjct: 105 LDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 289 HNQISSLQGLENHDLLEVINLEDNKIAELREIE 321
N IS E++ + L D + R I+
Sbjct: 165 RNPISE---AEDYKMFICAYLPDLMYLDYRRID 194
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 130 LNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNF 189
L+L L N++ + L + +L+KL L N IE + + + +L+ L+ S NN+ T
Sbjct: 46 LSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 190 KPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG---LEMCNNLIHLSLAN 246
NL+ +N+IS+I L A L L L N I+ + L L LSL+
Sbjct: 106 DTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSR 165
Query: 247 NKIT 250
N I+
Sbjct: 166 NPIS 169
>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/183 (34%), Positives = 90/183 (49%), Gaps = 1/183 (0%)
Query: 220 LILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKI-LCLSNNQIEMITGLED 278
L LD I I L NL L L NN I I GL L + L LS N IE I GL+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 279 LKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENP 338
L L++L L +N+IS + L+ L+V++L +N+I + I Y++ LR L+L NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 339 IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQ 398
I E +Y F+ L L LD ++I K A K+ + + Q++L Q
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQ 227
Query: 399 PQR 401
QR
Sbjct: 228 AQR 230
Score = 60.5 bits (145), Expect = 6e-09
Identities = 51/153 (33%), Positives = 73/153 (47%), Gaps = 7/153 (4%)
Query: 173 LLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG 232
+L L N+ N +NL+K +N I +I L L L L N IE I G
Sbjct: 45 VLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEG 104
Query: 233 LEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIE---MITGLEDLKALQNLDLS 288
L+ NL LSL NN+I+ I+ L+ L +++L L NN+I+ I L K L+ L LS
Sbjct: 105 LDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 289 HNQISSLQGLENHDLLEVINLEDNKIAELREIE 321
N IS E++ + L D + R I+
Sbjct: 165 RNPISE---AEDYKMFICAYLPDLMYLDYRRID 194
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 130 LNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNF 189
L+L L N++ + L + +L+KL L N IE + + + +L+ L+ S NN+ T
Sbjct: 46 LSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 190 KPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG---LEMCNNLIHLSLAN 246
NL+ +N+IS+I L A L L L N I+ + L L LSL+
Sbjct: 106 DTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSR 165
Query: 247 NKIT 250
N I+
Sbjct: 166 NPIS 169
>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 85.5 bits (210), Expect = 2e-16
Identities = 64/183 (34%), Positives = 90/183 (49%), Gaps = 1/183 (0%)
Query: 220 LILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKI-LCLSNNQIEMITGLED 278
L LD I I L NL L L NN I I GL L + L LS N IE I GL+
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 279 LKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENP 338
L L++L L +N+IS + L+ L+V++L +N+I + I Y++ LR L+L NP
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNP 167
Query: 339 IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKYDPPPEVVAAQDHLTHVVNSVMQ 398
I E +Y F+ L L LD ++I K A K+ + + Q++L Q
Sbjct: 168 ISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQENLMQAQLEDEQ 227
Query: 399 PQR 401
QR
Sbjct: 228 AQR 230
Score = 60.5 bits (145), Expect = 6e-09
Identities = 51/153 (33%), Positives = 73/153 (47%), Gaps = 7/153 (4%)
Query: 173 LLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG 232
+L L N+ N +NL+K +N I +I L L L L N IE I G
Sbjct: 45 VLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEG 104
Query: 233 LEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIE---MITGLEDLKALQNLDLS 288
L+ NL LSL NN+I+ I+ L+ L +++L L NN+I+ I L K L+ L LS
Sbjct: 105 LDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLS 164
Query: 289 HNQISSLQGLENHDLLEVINLEDNKIAELREIE 321
N IS E++ + L D + R I+
Sbjct: 165 RNPISE---AEDYKMFICAYLPDLMYLDYRRID 194
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 130 LNLTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNF 189
L+L L N++ + L + +L+KL L N IE + + + +L+ L+ S NN+ T
Sbjct: 46 LSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGL 105
Query: 190 KPPKNLKKADFSHNQISEICDLSAYHALTKLILDGNEIEEISG---LEMCNNLIHLSLAN 246
NL+ +N+IS+I L A L L L N I+ + L L LSL+
Sbjct: 106 DTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSR 165
Query: 247 NKIT 250
N I+
Sbjct: 166 NPIS 169
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 77.0 bits (188), Expect = 7e-14
Identities = 54/156 (34%), Positives = 85/156 (54%), Gaps = 3/156 (1%)
Query: 224 GNEIEEISGLEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIEMITGLEDLKAL 282
G + + I LE C L L+L+ N I I L+KL ++ L LS N+I I G+E++ L
Sbjct: 112 GKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNL 171
Query: 283 QNLDLSHNQISSLQGLENHDL--LEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQ 340
Q L+L+ N+I + L L V+NL+ NKI+ L++I +K L L L L+ENP+
Sbjct: 172 QKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVV 231
Query: 341 EKSEYWFFVIFMLLRLTELDQKKIKVEEKVSAVNKY 376
Y F IF L L L+ + + +++ A ++
Sbjct: 232 TLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERF 267
Score = 45.8 bits (107), Expect = 2e-04
Identities = 56/205 (27%), Positives = 94/205 (45%), Gaps = 14/205 (6%)
Query: 130 LNLTLS---GCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTF 186
LNL+LS G + L V L+ L+LS N I + + + L ELN S N ++
Sbjct: 103 LNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKI 162
Query: 187 FNFKPPKNLKKADFSHNQISEICDL--SAYHALTKLILDGNEI---EEISGLEMCNNLIH 241
+ NL+K + + N+I I +L L L GN+I ++IS L+ +LI
Sbjct: 163 EGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLIS 222
Query: 242 LSLANNKITTINGLNKLPI-KILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN 300
L L N + T+ + I + L + + + +T + +A + L ++ LE
Sbjct: 223 LILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSL-----EEVERLER 277
Query: 301 HDLLEVINLEDNKIAELREIEYIKN 325
++I E+ K + R +E IKN
Sbjct: 278 DLEKKMIETEELKSKQTRFLEEIKN 302
Score = 40.8 bits (94), Expect = 0.005
Identities = 40/127 (31%), Positives = 61/127 (48%), Gaps = 7/127 (5%)
Query: 248 KITTINGLNKLPIKILCLSNN---QIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLL 304
K+T + L + L LS + + + I LE L+ L+LS+N I ++ L+ L
Sbjct: 90 KLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKL 149
Query: 305 EVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELDQKKI 364
+NL NKI++ IE I+N+ L+ LNL N I E W LR+ L KI
Sbjct: 150 RELNLSYNKISK---IEGIENMCNLQKLNLAGNEI-EHIPVWLGKKLKSLRVLNLKGNKI 205
Query: 365 KVEEKVS 371
+ +S
Sbjct: 206 SSLQDIS 212
>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
Length = 725
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/168 (31%), Positives = 86/168 (51%), Gaps = 5/168 (2%)
Query: 210 DLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLP-IKILCLSNN 268
+L Y L L L N I++I LE L L L N + I L L + L LSNN
Sbjct: 124 NLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNN 183
Query: 269 QIEMITGLEDLKALQNLDLSHNQISSLQGLENHD---LLEVINLEDNKIAELREIEYIKN 325
I+ I L L L L ++HN + +++ +++ L V++L NK+++ + +++
Sbjct: 184 YIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILES 243
Query: 326 LPILRVLNLLENP-IQEKSEYWFFVIFMLLRLTELDQKKIKVEEKVSA 372
+P LRVLNL+ NP I++ Y V L LT LD + + +++ A
Sbjct: 244 MPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACA 291
Score = 33.9 bits (76), Expect = 0.63
Identities = 26/76 (34%), Positives = 40/76 (52%), Gaps = 6/76 (7%)
Query: 151 LQKLD---LSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPK---NLKKADFSHNQ 204
LQKLD LS N I+ + +SC+P L L + N+L T + + + L D SHN+
Sbjct: 172 LQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNK 231
Query: 205 ISEICDLSAYHALTKL 220
+S+ LS ++ L
Sbjct: 232 LSDPEILSILESMPDL 247
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/188 (26%), Positives = 84/188 (44%), Gaps = 9/188 (4%)
Query: 414 YPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDE 473
Y +++L GP G EL +L + ++ HTTR E D V+Y FIS+ +F+
Sbjct: 368 YRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFET 427
Query: 474 MVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVV 533
V KFI Y N+ YG + D+V + + ++ V+ L+ F+P I +
Sbjct: 428 DVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIK 487
Query: 534 PMNKEKYEGYLRRKGLFSRAEIE-----FAVSRVDLYIK----INQNFPGYFDEVINADD 584
P + E+ + + S + + F IK + + FD++I DD
Sbjct: 488 PPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDD 547
Query: 585 LDVAYQKL 592
L VA+ +L
Sbjct: 548 LTVAFNEL 555
>gi|66472382 nischarin [Homo sapiens]
Length = 1504
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/154 (33%), Positives = 78/154 (50%), Gaps = 25/154 (16%)
Query: 195 LKKADFSHNQISEICD-LSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTIN 253
L D SHN ISEI + + + L L N + + L+ NL+HL L+ NK++++
Sbjct: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
Query: 254 GLN-KLP-IKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLED 311
GL+ KL IK L L+ N +E ++GL L +L NLDL D
Sbjct: 349 GLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDL----------------------RD 386
Query: 312 NKIAELREIEYIKNLPILRVLNLLENPIQEKSEY 345
N+I ++ E+ I +LP L ++LL NP+ +Y
Sbjct: 387 NRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDY 420
Score = 35.8 bits (81), Expect = 0.17
Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 27/129 (20%)
Query: 151 LQKLDLSANKIEDLS-CVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEIC 209
L LDLS N I ++ V +P + L+ S N L N + NL D S+N++S +
Sbjct: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYNKLSSLE 348
Query: 210 --------------------DLSAYHALTKLI---LDGNEIEEISGLEMCNN---LIHLS 243
LS H L L+ L N IE++ + + L H+S
Sbjct: 349 GLHTKLGNIKTLNLAGNLLESLSGLHKLYSLVNLDLRDNRIEQMEEVRSIGSLPCLEHVS 408
Query: 244 LANNKITTI 252
L NN ++ I
Sbjct: 409 LLNNPLSII 417
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 67.8 bits (164), Expect = 4e-11
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 9/162 (5%)
Query: 443 RYGAC--HTTRPPYFGEGDRVDYHF-ISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVE 499
++G+C HTTRP E D DYHF +S++ ++ + KFI + ++ YG + +V
Sbjct: 346 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 405
Query: 500 GIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAV 559
+A G + + ++ L+ + P I + P + E RR+ E A
Sbjct: 406 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQ------TYEQAN 459
Query: 560 SRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLG 601
D +K+ Q F YF ++ D L+ Y K+ Q+I + G
Sbjct: 460 KIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSG 501
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 67.8 bits (164), Expect = 4e-11
Identities = 44/162 (27%), Positives = 76/162 (46%), Gaps = 9/162 (5%)
Query: 443 RYGAC--HTTRPPYFGEGDRVDYHF-ISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVE 499
++G+C HTTRP E D DYHF +S++ ++ + KFI + ++ YG + +V
Sbjct: 651 KFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVR 710
Query: 500 GIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAV 559
+A G + + ++ L+ + P I + P + E RR+ E A
Sbjct: 711 AVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQ------TYEQAN 764
Query: 560 SRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLG 601
D +K+ Q F YF ++ D L+ Y K+ Q+I + G
Sbjct: 765 KIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSG 806
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 9/162 (5%)
Query: 443 RYGAC--HTTRPPYFGEGDRVDYHFI-SQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVE 499
++G+C HTTRP E D DYHF+ S++ ++ + KFI Y NH YG + +V
Sbjct: 738 KFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVR 797
Query: 500 GIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAV 559
+A G + + ++ L+ + P I + P + E + R E A
Sbjct: 798 EVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI------MEMNKRLTEEQAR 851
Query: 560 SRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLG 601
+ +K+ Q F +F ++ D L+ Y ++ Q+I E G
Sbjct: 852 KTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSG 893
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/162 (27%), Positives = 75/162 (46%), Gaps = 9/162 (5%)
Query: 443 RYGAC--HTTRPPYFGEGDRVDYHFI-SQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVE 499
++G+C HTTRP E D DYHF+ S++ ++ + KFI Y NH YG + +V
Sbjct: 760 KFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVR 819
Query: 500 GIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAV 559
+A G + + ++ L+ + P I + P + E + R E A
Sbjct: 820 EVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENI------MEMNKRLTEEQAR 873
Query: 560 SRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLG 601
+ +K+ Q F +F ++ D L+ Y ++ Q+I E G
Sbjct: 874 KTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSG 915
>gi|239752518 PREDICTED: similar to leucine rich repeat containing
50, partial [Homo sapiens]
Length = 489
Score = 67.4 bits (163), Expect = 5e-11
Identities = 42/136 (30%), Positives = 74/136 (54%), Gaps = 1/136 (0%)
Query: 235 MCNNLIHLSLANNKITTINGLNKL-PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQIS 293
M +NL L L N+IT I +N L +++L L+ N + + L L +L L+L HNQI+
Sbjct: 1 MSSNLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQIT 60
Query: 294 SLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFML 353
++ ++N L+ + L N I+ + + + L + NPI ++S Y V+ +
Sbjct: 61 FVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNM 120
Query: 354 LRLTELDQKKIKVEEK 369
++L +LD K+I EE+
Sbjct: 121 MQLRQLDMKRITEEER 136
Score = 36.6 bits (83), Expect = 0.098
Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 3/103 (2%)
Query: 150 HLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEIC 209
+L LDL N+I + ++ + L LN ++N L+ N +L + + HNQI+ +
Sbjct: 4 NLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVR 63
Query: 210 DLSAYHALTKLILDGNEI---EEISGLEMCNNLIHLSLANNKI 249
D+ L L L N I + +S L ++L ++ N I
Sbjct: 64 DVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPI 106
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 67.4 bits (163), Expect = 5e-11
Identities = 63/244 (25%), Positives = 106/244 (43%), Gaps = 38/244 (15%)
Query: 132 LTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKP 191
L+L C L + L L+ +D N IE + C + + L + ++N LT+
Sbjct: 823 LSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECEN-LENLCVVLLNKNQLTSLHGLDG 881
Query: 192 PKNLKKADFSHNQISEI--------------------------CDLSAYHALTKLILDGN 225
N++ + S+N+I+ I L+ T L
Sbjct: 882 CTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWI 941
Query: 226 EIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNL 285
I ++ CN LI N + ++ L +L L +NQ+ GL D + L
Sbjct: 942 PITSLTKNSDCNFLISHLYWNCGLESLKNLQQL-----ILDHNQLINTKGLCDTPTIVYL 996
Query: 286 DLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPI---QEK 342
D SHN ++ ++G+EN LL+++ L+ N ++EL +E NL +LR L+L +N I +
Sbjct: 997 DCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLE---NLVLLRELHLDDNSISTVEAF 1053
Query: 343 SEYW 346
S YW
Sbjct: 1054 SSYW 1057
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 27/153 (17%)
Query: 199 DFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNK- 257
D SHN ++++ + L L L GN + E+ LE L L L +N I+T+ +
Sbjct: 997 DCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSY 1056
Query: 258 -LP-IKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQ---------------GLEN 300
LP ++ + +S N + I L +L+ LD+SHN +S L+ L
Sbjct: 1057 WLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTG 1116
Query: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLN 333
+ LL+ N D+ +K LP LR+LN
Sbjct: 1117 NPLLQETNWRDS---------LLKVLPALRILN 1140
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 2/89 (2%)
Query: 230 ISGLEMCNNLIHLSLANNKITTINGL-NKLPIKILCLSNNQIEMITGLEDLKALQNLDLS 288
+S L C NL LSL +T+++ L N +K + N IE I E+L+ L + L+
Sbjct: 811 LSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLN 869
Query: 289 HNQISSLQGLENHDLLEVINLEDNKIAEL 317
NQ++SL GL+ ++ + L NKI +
Sbjct: 870 KNQLTSLHGLDGCTNIQCLELSYNKITRI 898
Score = 38.9 bits (89), Expect = 0.020
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 132 LTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSC--MPYLLELNASQNNLTTFFNF 189
L L G L ++ L V L++L L N I + S +P L + SQN+LT
Sbjct: 1018 LKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPL 1077
Query: 190 KPPKNLKKADFSHNQISEICD----LSAYHALTKLILDGNEI 227
+L+K D SHN +S++ A ++L +L L GN +
Sbjct: 1078 FHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPL 1119
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 67.4 bits (163), Expect = 5e-11
Identities = 63/244 (25%), Positives = 106/244 (43%), Gaps = 38/244 (15%)
Query: 132 LTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKP 191
L+L C L + L L+ +D N IE + C + + L + ++N LT+
Sbjct: 823 LSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIECEN-LENLCVVLLNKNQLTSLHGLDG 881
Query: 192 PKNLKKADFSHNQISEI--------------------------CDLSAYHALTKLILDGN 225
N++ + S+N+I+ I L+ T L
Sbjct: 882 CTNIQCLELSYNKITRIGYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWI 941
Query: 226 EIEEISGLEMCNNLIHLSLANNKITTINGLNKLPIKILCLSNNQIEMITGLEDLKALQNL 285
I ++ CN LI N + ++ L +L L +NQ+ GL D + L
Sbjct: 942 PITSLTKNSDCNFLISHLYWNCGLESLKNLQQL-----ILDHNQLINTKGLCDTPTIVYL 996
Query: 286 DLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPI---QEK 342
D SHN ++ ++G+EN LL+++ L+ N ++EL +E NL +LR L+L +N I +
Sbjct: 997 DCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLE---NLVLLRELHLDDNSISTVEAF 1053
Query: 343 SEYW 346
S YW
Sbjct: 1054 SSYW 1057
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/153 (28%), Positives = 70/153 (45%), Gaps = 27/153 (17%)
Query: 199 DFSHNQISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNK- 257
D SHN ++++ + L L L GN + E+ LE L L L +N I+T+ +
Sbjct: 997 DCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSY 1056
Query: 258 -LP-IKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQ---------------GLEN 300
LP ++ + +S N + I L +L+ LD+SHN +S L+ L
Sbjct: 1057 WLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTG 1116
Query: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLN 333
+ LL+ N D+ +K LP LR+LN
Sbjct: 1117 NPLLQETNWRDS---------LLKVLPALRILN 1140
Score = 41.2 bits (95), Expect = 0.004
Identities = 30/89 (33%), Positives = 48/89 (53%), Gaps = 2/89 (2%)
Query: 230 ISGLEMCNNLIHLSLANNKITTINGL-NKLPIKILCLSNNQIEMITGLEDLKALQNLDLS 288
+S L C NL LSL +T+++ L N +K + N IE I E+L+ L + L+
Sbjct: 811 LSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLN 869
Query: 289 HNQISSLQGLENHDLLEVINLEDNKIAEL 317
NQ++SL GL+ ++ + L NKI +
Sbjct: 870 KNQLTSLHGLDGCTNIQCLELSYNKITRI 898
Score = 38.9 bits (89), Expect = 0.020
Identities = 32/102 (31%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 132 LTLSGCNLIDVSILCGYVHLQKLDLSANKIEDLSCVSC--MPYLLELNASQNNLTTFFNF 189
L L G L ++ L V L++L L N I + S +P L + SQN+LT
Sbjct: 1018 LKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPL 1077
Query: 190 KPPKNLKKADFSHNQISEICD----LSAYHALTKLILDGNEI 227
+L+K D SHN +S++ A ++L +L L GN +
Sbjct: 1078 FHFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPL 1119
>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
Length = 466
Score = 66.6 bits (161), Expect = 9e-11
Identities = 47/141 (33%), Positives = 75/141 (53%), Gaps = 2/141 (1%)
Query: 238 NLIHLSLANNKITTINGLNKL--PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSL 295
+L LSL +I + ++K +KIL L NN I I + LK L+ L+L+ N I +
Sbjct: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
Query: 296 QGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLR 355
+ LE + L ++L N I EL I+ +++ L+ L L+ NP Y FV+ L +
Sbjct: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
Query: 356 LTELDQKKIKVEEKVSAVNKY 376
L LD K+I+ E++ A+ Y
Sbjct: 142 LKWLDGKEIEPSERIKALQDY 162
Score = 37.0 bits (84), Expect = 0.075
Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 11/155 (7%)
Query: 146 CGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLT-TFFNFKPPKNLKKADFSHNQ 204
C L++L L +IE L + L++ QNNL N K L+ + + N
Sbjct: 18 CVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNN 77
Query: 205 ISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLS---LANNKITTINGLNKLPIK 261
I +I +L L KL L N I E+S ++ + IHL L N + + + +
Sbjct: 78 IEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVA 137
Query: 262 IL----CLSNNQIEMITGLEDLKALQNLDLSHNQI 292
L L +IE E +KALQ+ + QI
Sbjct: 138 TLPQLKWLDGKEIE---PSERIKALQDYSVIEPQI 169
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 443 RYGAC--HTTRPPYFGEGDRVDYHFIS-QDVFDEMVNMGKFILTFSYGNHKYGLNRDTVE 499
++G+C HTTRP E D DYHF+S ++ ++ + KFI Y +H YG + +V
Sbjct: 601 KFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVR 660
Query: 500 GIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAV 559
+A G + + VR L+ ++ P I + P + E + R E A
Sbjct: 661 EVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENV------LEINKRITEEQAR 714
Query: 560 SRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLG 601
D K+ Q F F ++ D + Y K+ ++I + G
Sbjct: 715 KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSG 756
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/162 (27%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 443 RYGAC--HTTRPPYFGEGDRVDYHFIS-QDVFDEMVNMGKFILTFSYGNHKYGLNRDTVE 499
++G+C HTTRP E D DYHF+S ++ ++ + KFI Y +H YG + +V
Sbjct: 555 KFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVR 614
Query: 500 GIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAV 559
+A G + + VR L+ ++ P I + P + E + R E A
Sbjct: 615 EVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENV------LEINKRITEEQAR 668
Query: 560 SRVDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIREYLG 601
D K+ Q F F ++ D + Y K+ ++I + G
Sbjct: 669 KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSG 710
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 66.2 bits (160), Expect = 1e-10
Identities = 44/199 (22%), Positives = 87/199 (43%), Gaps = 9/199 (4%)
Query: 414 YPMLILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDE 473
Y +++L GP G EL +L ++F+ HTTR E + +YH++S++ F+
Sbjct: 427 YRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFEN 486
Query: 474 MVNMGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVV 533
++ + + Y H YG + D V+ + +G + +E + ++ ++ +P I +
Sbjct: 487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIK 546
Query: 534 PMNKEKYEGYLRRKGLFSRAEIEFAVSRVDLY------IKINQNFPGYFDEVINADDLDV 587
P N + + + + ++ DL ++ F +FD VI D L
Sbjct: 547 PSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSL-- 604
Query: 588 AYQKLSQLIREYLGLTEEP 606
+ +QL+ EEP
Sbjct: 605 -HDACAQLLSAIQKAQEEP 622
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 66.2 bits (160), Expect = 1e-10
Identities = 69/240 (28%), Positives = 121/240 (50%), Gaps = 35/240 (14%)
Query: 151 LQKLDLSANKIEDLSC-VSCMPYLLELNASQNNLTTFFN-FKPPKNLKKADFSHNQISEI 208
L KL +S NK++ L+ + +P L L+ N LT+ + + +NL+K + SHN++ +
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 209 CD-LSAYHALTKLILDGNEIEEIS-GLEMCNNLIHLSLANNKITTI-------------- 252
+ ++ L L L NE+ IS G E +NL L L+NN +TT+
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 253 ---NGLNKLP--------IKILCLSNNQIEMI-TGLEDLKALQNLDLSHNQISSLQGLEN 300
N L LP +K L ++N +E I L +++L+ L L N++ L +
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPS 263
Query: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
LL+ +++ +N+I E+ E E++K+L + VL+L +N ++ + I +L L LD
Sbjct: 264 CSLLKELHVGENQI-EMLEAEHLKHLNSILVLDLRDNKLKSVPD----EIILLRSLERLD 318
Score = 51.2 bits (121), Expect = 4e-06
Identities = 51/178 (28%), Positives = 87/178 (48%), Gaps = 11/178 (6%)
Query: 150 HLQKLDLSANKIEDL-SCVSCMPYLLELNASQNNLTTF-FNFKPPKNLKKADFSHNQISE 207
+L+ LDLS N + + + S + L+ LN S N L + K LK D + N +
Sbjct: 175 NLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLET 234
Query: 208 IC-DLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTING-----LNKLPIK 261
I +L+ +L L L N++ + C+ L L + N+I + LN I
Sbjct: 235 IPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNS--IL 292
Query: 262 ILCLSNNQIEMITG-LEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELR 318
+L L +N+++ + + L++L+ LDLS+N ISSL + L+ + LE N + +R
Sbjct: 293 VLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIR 350
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,773,183
Number of Sequences: 37866
Number of extensions: 1597022
Number of successful extensions: 6606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 210
Number of HSP's that attempted gapping in prelim test: 5779
Number of HSP's gapped (non-prelim): 726
length of query: 825
length of database: 18,247,518
effective HSP length: 111
effective length of query: 714
effective length of database: 14,044,392
effective search space: 10027695888
effective search space used: 10027695888
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.