Search of human proteins with 21313638

Search of human proteins with 21313638

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21313638 leucine-rich repeat LGI family, member 2 [Homo
sapiens]
         (545 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21313638 leucine-rich repeat LGI family, member 2 [Homo sapiens]  1102   0.0  
gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo sa...   632   0.0  
gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens]   590   e-168
gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens]   434   e-121
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                102   1e-21
gi|11321571 slit homolog 3 [Homo sapiens]                              98   2e-20
gi|188528675 slit homolog 1 [Homo sapiens]                             96   6e-20
gi|4759146 slit homolog 2 [Homo sapiens]                               96   8e-20
gi|15029530 leucine rich repeat containing 4 [Homo sapiens]            90   6e-18
gi|59823631 G protein-coupled receptor 125 [Homo sapiens]              90   6e-18
gi|40255157 leucine-rich repeats and immunoglobulin-like domains...    86   9e-17
gi|209862903 leucine-rich repeats and immunoglobulin-like domain...    86   9e-17
gi|109150416 peroxidasin [Homo sapiens]                                86   9e-17
gi|54607118 leucine-rich repeats and immunoglobulin-like domains...    86   1e-16
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho...    85   1e-16
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ...    83   6e-16
gi|126517478 peroxidasin homolog-like [Homo sapiens]                   82   1e-15
gi|51317373 netrin-G1 ligand [Homo sapiens]                            81   2e-15
gi|40217825 slit and trk like 6 [Homo sapiens]                         81   3e-15
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom...    81   3e-15
gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]         79   1e-14
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre...    79   1e-14
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec...    79   1e-14
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]                 79   1e-14
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              78   2e-14
gi|122937309 leucine rich repeat containing 4B [Homo sapiens]          78   2e-14
gi|88702793 slit-like 2 [Homo sapiens]                                 77   3e-14
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo...    76   9e-14
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]          75   1e-13
gi|116268101 leucine rich repeat containing 62 [Homo sapiens]          75   1e-13

>gi|21313638 leucine-rich repeat LGI family, member 2 [Homo sapiens]
          Length = 545

 Score = 1102 bits (2850), Expect = 0.0
 Identities = 545/545 (100%), Positives = 545/545 (100%)

Query: 1   MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP 60
           MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP
Sbjct: 1   MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP 60

Query: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120
           GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK
Sbjct: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120

Query: 121 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL 180
           IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL
Sbjct: 121 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL 180

Query: 181 WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN 240
           WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN
Sbjct: 181 WLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKN 240

Query: 241 DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS 300
           DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS
Sbjct: 241 DVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGS 300

Query: 301 HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG 360
           HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG
Sbjct: 301 HIYKYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKG 360

Query: 361 FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV 420
           FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV
Sbjct: 361 FYSYQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDV 420

Query: 421 LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL 480
           LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL
Sbjct: 421 LAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLAL 480

Query: 481 GSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHII 540
           GSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHII
Sbjct: 481 GSDYTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHII 540

Query: 541 VDLSL 545
           VDLSL
Sbjct: 541 VDLSL 545


>gi|4826816 leucine-rich, glioma inactivated 1 precursor [Homo
           sapiens]
          Length = 557

 Score =  632 bits (1629), Expect = 0.0
 Identities = 297/516 (57%), Positives = 381/516 (73%), Gaps = 6/516 (1%)

Query: 35  RCPATCSCTKESIICVGSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNS 94
           +CPA C+CTK++ +C  +  +PR VP D+ SLS V   F+EI +  F   PSLQLLL  S
Sbjct: 41  KCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTS 100

Query: 95  NSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFS 154
           NSF +I DDAF GL HLEYLFIE N I++ISR+ FRGL+ L HLSLANN+++ LP+D+F 
Sbjct: 101 NSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFK 160

Query: 155 DLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYE 214
            LDSL  +DLRGN F CDCK KWL  WL  TN+TV D+ C GPPEY+++K+N ++S D++
Sbjct: 161 GLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFD 220

Query: 215 CTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQPSMENCMVLEWDHIEMNFRSYDNITG 274
           C  T+F   Q LPYQS+S+DTF+  ND YV IAQP    C+ LEWDH+E  FR+YDNITG
Sbjct: 221 CIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITG 280

Query: 275 QSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDESWTKFVKFQDIEVSRISKPNDIELFQI 334
            S V CK I+I+ Q++V+VAQLFGGSHIYK D    KF+K QDIE+ +I KPNDIE F+I
Sbjct: 281 TSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKI 340

Query: 335 DDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLHEWFRDTDAEFVDID------GKSHLI 388
           ++  +FV+ADSSKAG +T+YKWN  GFYS+QSLH W+RDTD E+++I          HLI
Sbjct: 341 ENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRTPQTLRTPHLI 400

Query: 389 LSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 448
           LSS SQ P+I QWNK+++ F    DIPNMEDV AVK F ++  +Y+ LTRFIGDS+VM+W
Sbjct: 401 LSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKW 460

Query: 449 NSKQFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQWDKEKQLFKKFKEIYVQ 508
               F +IQ +PSRG+M  QP    +  Y  LGSDY+F+Q+Y WD EK  F KF+E+ VQ
Sbjct: 461 GGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQ 520

Query: 509 APRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLS 544
           APRSFT VS ++R+F FASSFKG T+I++H+IVDLS
Sbjct: 521 APRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLS 556


>gi|21281681 leucine-rich repeat LGI family, member 3 [Homo sapiens]
          Length = 548

 Score =  590 bits (1521), Expect = e-168
 Identities = 278/541 (51%), Positives = 382/541 (70%), Gaps = 1/541 (0%)

Query: 5   RGGCGALGLLLLLLGAACLIPRSAQ-VRRLARCPATCSCTKESIICVGSSWVPRIVPGDI 63
           RGG G   L L  LG   ++  SA+   +   CP +CSCT+++  CV S  VPR +P ++
Sbjct: 7   RGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEV 66

Query: 64  SSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIET 123
            SL+LVN  FSEI+D  FSHLP LQ LLLNSN FT+I D+AF GL HL+YLFIE N I  
Sbjct: 67  ISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWA 126

Query: 124 ISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLK 183
           +S+  FRGL+ LTHLSLANN+++ LPRD+F  LD L +LDLRGN   CDCK KWL  WL 
Sbjct: 127 LSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLA 186

Query: 184 MTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKNDVY 243
            TN+TV+ + C  PP +QE K+ D+   +++C TTDFV++QTL + +VS + F   +D+Y
Sbjct: 187 HTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLY 246

Query: 244 VAIAQPSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIY 303
           +A+AQP +  C +L+WD++E   R YD I   S V CK +++D Q++VVVAQLFGGS+IY
Sbjct: 247 LALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIY 306

Query: 304 KYDESWTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKGFYS 363
            +D + T+F + QDI+  R+ KPND+E F+ID + +F +ADSSKAG +++Y+W+  GFYS
Sbjct: 307 HWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYS 366

Query: 364 YQSLHEWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAV 423
           +Q+LH W RDTD EFVD +GK  LI+SS SQ P+I QW+++ K+FV  G++  + D  AV
Sbjct: 367 HQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAV 426

Query: 424 KSFRMQNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLALGSD 483
           K FR     YL L+R+IGDS+++RW   +F E+QALPSRG++ LQPF      YLALGSD
Sbjct: 427 KHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSD 486

Query: 484 YTFSQIYQWDKEKQLFKKFKEIYVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDL 543
           ++F+QIYQWD+ +Q F +F+E+ VQAPR+F  +         A SFKG+T ++ HI+VDL
Sbjct: 487 FSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHIVVDL 546

Query: 544 S 544
           S
Sbjct: 547 S 547


>gi|21281673 leucine-rich repeat LGI family, member 4 [Homo sapiens]
          Length = 537

 Score =  434 bits (1116), Expect = e-121
 Identities = 220/539 (40%), Positives = 329/539 (61%), Gaps = 7/539 (1%)

Query: 9   GALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVPGDISSLSL 68
           G  G+LLLLL  A ++      +   +CP  CSC+K+S +C GS  +P      + SLSL
Sbjct: 2   GGAGILLLLLAGAGVVVAWRPPK--GKCPLRCSCSKDSALCEGSPDLPVSFSPTLLSLSL 59

Query: 69  VNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNA 128
           V    +++K   F  +PSL LLL  SNSF++I DDAFAGL HL+YLFIE N+I +IS+NA
Sbjct: 60  VRTGVTQLKAGSFLRIPSLHLLLFTSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNA 119

Query: 129 FRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNST 188
            RGLR LTHLSLANNH++ LPR +F  LD+L  +DLRGN F+CDC+  WL  W+   N++
Sbjct: 120 LRGLRSLTHLSLANNHLETLPRFLFRGLDTLTHVDLRGNPFQCDCRVLWLLQWMPTVNAS 179

Query: 189 VSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNSKNDVYVAIAQ 248
           V    C GP      +L+ +    ++C   +    QT+   ++SV+ F+ + + ++ +AQ
Sbjct: 180 VGTGACAGPASLSHMQLHHLDPKTFKCRAIELSWFQTVGESALSVEPFSYQGEPHIVLAQ 239

Query: 249 PSMENCMVLEWDHIEMNFRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKYDES 308
           P    C++L WD+    FR  + +   S+V CK +++   +FV+ A+L+GGS ++     
Sbjct: 240 PFAGRCLILSWDYSLQRFRPEEELPAASVVSCKPLVLGPSLFVLAARLWGGSQLWARPSP 299

Query: 309 WTKFVKFQDIEVSRISKPNDIELFQIDDETFFVIADSSKAGLSTVYKWNSKGFYSYQSLH 368
             +    Q +   R+ +PND EL  ++ +  FV+AD+SKAG +T+   +  GFY +QSLH
Sbjct: 300 GLRLAPTQTLAPRRLLRPNDAELLWLEGQPCFVVADASKAGSTTLLCRDGPGFYPHQSLH 359

Query: 369 EWFRDTDAEFVDIDGKSHLILSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRM 428
            W RDTDAE +++DG+ HL+L+S SQ P++  W  +  +F    DIP  EDV A + F+ 
Sbjct: 360 AWHRDTDAEALELDGRPHLLLASASQRPVLFHW--TGGRFERRTDIPEAEDVYATRHFQA 417

Query: 429 QNTLYLSLTRFIGDSRVMRWNSKQFVEIQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQ 488
              ++L LTR+IGDS VMRW+   F  +Q LPSRGA   QP     +    LGSD+ FSQ
Sbjct: 418 GGDVFLCLTRYIGDSMVMRWDGSMFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQ 477

Query: 489 IYQWDKEKQLFKKFKEI---YVQAPRSFTAVSTDRRDFFFASSFKGKTKIFEHIIVDLS 544
           + + + +K L +  +E+    + APR+F  ++   R F FA+ FKG T+I++H  +DLS
Sbjct: 478 VLRLEPDKGLLEPLQELGPPALVAPRAFAHITMAGRRFLFAACFKGPTQIYQHHEIDLS 536


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score =  102 bits (253), Expect = 1e-21
 Identities = 53/149 (35%), Positives = 83/149 (55%)

Query: 66  LSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETIS 125
           L L   +   ++D +F+ L +L  L L+ N   ++ +  F GL  L+ L + GN+++ + 
Sbjct: 160 LYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVH 219

Query: 126 RNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMT 185
           R AFRGL  LT L L NN + +LP +  +DL SL  L L  N + CDC+A+ L+ W +  
Sbjct: 220 RAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRA 279

Query: 186 NSTVSDVLCIGPPEYQEKKLNDVTSFDYE 214
             + SDV C  PPE Q + L  +   D++
Sbjct: 280 RVSSSDVTCATPPERQGRDLRALREADFQ 308


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 3/183 (1%)

Query: 35  RCPATCSCTKESIICV--GSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLL 92
           RCP  C+C +  + C   G   +PR +P D++ L L     + +  R  S L  L L+ L
Sbjct: 724 RCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVP-RELSALRHLTLIDL 782

Query: 93  NSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDV 152
           ++NS +++ +  F+ + HL  L +  N++  I  +AF GLR L  L+L  N I ++P   
Sbjct: 783 SNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGS 842

Query: 153 FSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFD 212
           F+DL SL  L L  N   CDC  +WL  W+K          C  P    ++ L    +  
Sbjct: 843 FNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHR 902

Query: 213 YEC 215
           ++C
Sbjct: 903 FQC 905



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 57/210 (27%), Positives = 91/210 (43%), Gaps = 26/210 (12%)

Query: 36  CPATCSCTKESIICVGSSW--VPRIVPGDISSLSLVNGTF-------------------- 73
           CP+ C+C+   + C G     +P  +P  I  + L   +                     
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339

Query: 74  ----SEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAF 129
               S+I    F  L SL  L+L  N  T I    F GL  L+ L +  NKI  +  N F
Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399

Query: 130 RGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV 189
           + L++L  LSL +N ++ + + +F+ L S+  L L  N F CDC  KWL  +L+      
Sbjct: 400 QDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET 459

Query: 190 SDVLCIGPPEYQEKKLNDVTSFDYECTTTD 219
           S   C  P     K+++ + S  + C+ ++
Sbjct: 460 SGARCSSPRRLANKRISQIKSKKFRCSGSE 489



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 62/230 (26%), Positives = 92/230 (40%), Gaps = 50/230 (21%)

Query: 36  CPATCSCTKESIIC--VGSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLN 93
           CP  C+C+  S+ C  +G   VPR +P +   L L     + I    F+ L +L++L L 
Sbjct: 34  CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLE 93

Query: 94  SNSFTIIRDDAFAGLFHLEYLFIEGNKIET------------------------ISRNAF 129
            N  ++I   AF  L  LE L +  NK++                         I R AF
Sbjct: 94  DNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAF 153

Query: 130 RGLRDLTHLSLANNHIKALP-------RDV-----------------FSDLDSLIELDLR 165
           RG+ D+ +L L NNHI  +        RD+                 F+ +  +  L L 
Sbjct: 154 RGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLH 213

Query: 166 GNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYEC 215
            N   CDC   WL  WL+   +     LC+ P   +   + DV   +Y C
Sbjct: 214 SNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVC 263



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 56/207 (27%), Positives = 88/207 (42%), Gaps = 27/207 (13%)

Query: 36  CPATCSCTKESIICVGSSWV--PRIVPGDISSLSLVNGTFSEIKDR-MFSHLPSLQLLLL 92
           CP  C C    + C     V  P  +P  ++ L L +   S ++   +F  LP+L+ + L
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINL 564

Query: 93  NSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDV 152
           ++N    +R+ AF G   ++ L + GN++ET+    FRGL  L  L L +N I  +  D 
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624

Query: 153 FSDLDS------------------------LIELDLRGNKFECDCKAKWLYLWLKMTNST 188
           F+ L S                        L  ++L  N F C+C   WL  WL+     
Sbjct: 625 FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIV 684

Query: 189 VSDVLCIGPPEYQEKKLNDVTSFDYEC 215
             +  C  P   +E  + DV   D+ C
Sbjct: 685 SGNPRCQKPFFLKEIPIQDVAIQDFTC 711


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score = 96.3 bits (238), Expect = 6e-20
 Identities = 64/221 (28%), Positives = 98/221 (44%), Gaps = 27/221 (12%)

Query: 36  CPATCSCTKESIICVGS--------------------SWVPRIVPGDISS------LSLV 69
           CPA C+C+   + C G                     + +  I PG  S       + L 
Sbjct: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341

Query: 70  NGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAF 129
           N   +EI    F  L SL  L+L  N  T +    F GL+ L+ L +  NKI  I  +AF
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401

Query: 130 RGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV 189
           + L++L+ LSL +N I++L +  F+ L ++  L L  N F CDC  KWL  +L+      
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET 461

Query: 190 SDVLCIGPPEYQEKKLNDVTSFDYECTTTD-FVVHQTLPYQ 229
           S   C  P     K++  + S  + C+  + + +  T  YQ
Sbjct: 462 SGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQ 502



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 53/183 (28%), Positives = 88/183 (48%), Gaps = 3/183 (1%)

Query: 35  RCPATCSCTKESIICVGSSW--VPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLL 92
           +CP  C+C    + C       +P+ +P +++ L L    F+ +  ++ S    LQL+ L
Sbjct: 733 QCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQL-STFKYLQLVDL 791

Query: 93  NSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDV 152
           ++N  + + + +F  +  L  L +  N ++ I   AF+GLR L  LSL  N I  L   +
Sbjct: 792 SNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGI 851

Query: 153 FSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFD 212
           F+D+ SL  L +  N   CDC  +WL  W+K          C GP + + K L    +  
Sbjct: 852 FADVTSLSHLAIGANPLYCDCHLRWLSSWVKTGYKEPGIARCAGPQDMEGKLLLTTPAKK 911

Query: 213 YEC 215
           +EC
Sbjct: 912 FEC 914



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 51/153 (33%), Positives = 73/153 (47%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIE 122
           +  ++L N   SEI+D  F    S+  L L +N    IR   F GL  L  L +  N+I 
Sbjct: 567 LKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRIS 626

Query: 123 TISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWL 182
            I  ++F GLR++  LSL +N I  +    F  L SL  L+L  N F C+C+  WL  WL
Sbjct: 627 CIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWL 686

Query: 183 KMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYEC 215
           +       +  C  P   ++  L DV   D+ C
Sbjct: 687 RKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRC 719



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 70/271 (25%), Positives = 102/271 (37%), Gaps = 62/271 (22%)

Query: 1   MALRRGGCGALG-----LLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSW- 54
           MAL  G   + G     L LLL  AA  +  SA       CPA C+CT  ++ C G+   
Sbjct: 1   MALTPGWGSSAGPVRPELWLLLWAAAWRLGASA-------CPALCTCTGTTVDCHGTGLQ 53

Query: 55  -VPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEY 113
            +P+ +P +   L L     + I    F+ L  L++L L  N    +   AF  +  LE 
Sbjct: 54  AIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELER 113

Query: 114 LFIEGNK------------------------IETISRNAFRG------------------ 131
           L +  N+                        I+ I R AFRG                  
Sbjct: 114 LRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIE 173

Query: 132 ------LRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMT 185
                 LR L  L+L NN+I  +P   F+ +  L    L  N   CDC   WL  WL+  
Sbjct: 174 EGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQR 233

Query: 186 NSTVSDVLCIGPPEYQEKKLNDVTSFDYECT 216
            +      C GP   +   + +V   ++ C+
Sbjct: 234 PTIGLFTQCSGPASLRGLNVAEVQKSEFSCS 264


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 55/185 (29%), Positives = 88/185 (47%), Gaps = 3/185 (1%)

Query: 33  LARCPATCSCTKESIICV--GSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLL 90
           L+RCP  C+C    + C   G   +P+ +P D++ L L    F+ +   + S+   L L+
Sbjct: 724 LSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKEL-SNYKHLTLI 782

Query: 91  LLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPR 150
            L++N  + + + +F+ +  L  L +  N++  I    F GL+ L  LSL  N I  +P 
Sbjct: 783 DLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPE 842

Query: 151 DVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTS 210
             F+DL +L  L +  N   CDC  +WL  W+K          C GP E  +K L    S
Sbjct: 843 GAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPS 902

Query: 211 FDYEC 215
             + C
Sbjct: 903 KKFTC 907



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 28/229 (12%)

Query: 36  CPATCSCTKESIICVGSSW--VPRIVPGDISSL------------------------SLV 69
           CPA C+C+   + C G     +P  +P  I+ +                         L 
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332

Query: 70  NGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAF 129
           N   SE+    F  L SL  L+L  N  T +    F GLF L+ L +  NKI  +  +AF
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392

Query: 130 RGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV 189
           + L +L  LSL +N ++ + +  FS L ++  + L  N F CDC  KWL  +L       
Sbjct: 393 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET 452

Query: 190 SDVLCIGPPEYQEKKLNDVTSFDYECTTTD-FVVHQTLPYQS-VSVDTF 236
           S   C  P     K++  + S  + C+  + + +  T  Y+S +S D F
Sbjct: 453 SGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCF 501



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 53/207 (25%), Positives = 83/207 (40%), Gaps = 27/207 (13%)

Query: 36  CPATCSCTKESIICVGSSW--VPRIVPGDISSLSLVNGTFSEIKDR-MFSHLPSLQLLLL 92
           CP  C C   ++ C       +P  +P   + L L N  F+ ++   +F  LP L+ +  
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565

Query: 93  NSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRD- 151
           ++N  T I + AF G   +  + +  N++E +    F+GL  L  L L +N I  +  D 
Sbjct: 566 SNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDS 625

Query: 152 -----------------------VFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNST 188
                                   F  L SL  L+L  N F C+C   WL  WL+     
Sbjct: 626 FIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIV 685

Query: 189 VSDVLCIGPPEYQEKKLNDVTSFDYEC 215
             +  C  P   +E  + DV   D+ C
Sbjct: 686 TGNPRCQKPYFLKEIPIQDVAIQDFTC 712



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 73/274 (26%), Positives = 105/274 (38%), Gaps = 65/274 (23%)

Query: 10  ALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSW--VPRIVPGDISSLS 67
           +LGL+L +L      P++        CPA CSC+  ++ C G +   VPR +P +   L 
Sbjct: 12  SLGLVLAILNKVA--PQA--------CPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD 61

Query: 68  LVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGN-------- 119
           L     + I    F+ L  L++L L  N  + I   AF  L  LE L +  N        
Sbjct: 62  LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPEL 121

Query: 120 ----------------KIETISRNAFRG------------------------LRDLTHLS 139
                           +I+ I R AFRG                        LRDL  L+
Sbjct: 122 LFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLT 181

Query: 140 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPE 199
           L NN+I  L    F+ +  L    L  N   CDC   WL  WL+          C+GP  
Sbjct: 182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSH 241

Query: 200 YQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSV 233
            +   + +V   ++ C+      HQ+    S SV
Sbjct: 242 LRGHNVAEVQKREFVCSG-----HQSFMAPSCSV 270


>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
          Length = 653

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 55/156 (35%), Positives = 84/156 (53%), Gaps = 5/156 (3%)

Query: 65  SLSLVNGTFSEIKDRM-FSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIET 123
           +L  +N     IKD    + L  L+ L ++ N F  IR  +F GL  L+ L++  +++  
Sbjct: 197 NLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSL 256

Query: 124 ISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLK 183
           I RNAF GL  L  L+LA+N++ +LP D+F+ L  L+EL L  N + CDC   WL  WL+
Sbjct: 257 IERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLR 316

Query: 184 ---MTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECT 216
               TNST     C  P   + + L +V    ++C+
Sbjct: 317 EYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQCS 351



 Score = 73.2 bits (178), Expect = 6e-13
 Identities = 47/133 (35%), Positives = 68/133 (51%), Gaps = 4/133 (3%)

Query: 36  CPATCSCTKE--SIICV--GSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLL 91
           CP+ CSC+ +   ++C   G S VP+ +P +   L+L+      I+   F HL  L++L 
Sbjct: 46  CPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQ 105

Query: 92  LNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRD 151
           L  NS   I   AF GL  L  L +  N +  I   AF  L  L  L L NN I+++P  
Sbjct: 106 LGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSY 165

Query: 152 VFSDLDSLIELDL 164
            F+ + SL+ LDL
Sbjct: 166 AFNRVPSLMRLDL 178


>gi|59823631 G protein-coupled receptor 125 [Homo sapiens]
          Length = 1321

 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 56/164 (34%), Positives = 81/164 (49%), Gaps = 3/164 (1%)

Query: 56  PRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLF 115
           P  +P    +L L N   SE+K+  FS L  L+ L L +N  + I   AF GL  L+ L 
Sbjct: 76  PDTLPNRTVTLILSNNKISELKNGSFSGLSLLERLDLRNNLISSIDPGAFWGLSSLKRLD 135

Query: 116 IEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKA 175
           +  N+I  ++ + FRGL +L  L+L+ N   +L +  F  L SL  L+ +     CDC  
Sbjct: 136 LTNNRIGCLNADIFRGLTNLVRLNLSGNLFSSLSQGTFDYLASLRSLEFQTEYLLCDCNI 195

Query: 176 KWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTD 219
            W++ W+K  N TV D  C+ P   Q +    VT    E  T D
Sbjct: 196 LWMHRWVKEKNITVRDTRCVYPKSLQAQ---PVTGVKQELLTCD 236


>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 2 [Homo sapiens]
          Length = 1119

 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 7/201 (3%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDD---AFAGLFHLEYLFIEGN 119
           +++L + N   S I D  F  L SL+ L L +N  +   +D   AF+GL  L  L ++GN
Sbjct: 337 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 396

Query: 120 KIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLY 179
           +I +I++ AF GL  L HL L++N I +L  + FS +  L +L L  +   CDC+ KWL 
Sbjct: 397 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP 456

Query: 180 LWLKMTN-STVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNS 238
            W+   N  +  +  C  P   + + +  V+   + C   DF   Q +  Q  +      
Sbjct: 457 QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVC--DDFPKPQ-ITVQPETQSAIKG 513

Query: 239 KNDVYVAIAQPSMENCMVLEW 259
            N  ++  A  S ++ M   W
Sbjct: 514 SNLSFICSAASSSDSPMTFAW 534



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 33/115 (28%), Positives = 54/115 (46%), Gaps = 3/115 (2%)

Query: 36  CPATCSCTKESIICVGS--SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLN 93
           CP TC C  + + C     + +P  +P  ++ L L +   S IK    SHL SL+ + LN
Sbjct: 47  CPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLN 106

Query: 94  SNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKAL 148
           +N    I +       ++  L + GN+I  I     +  + L  L L++N+I  L
Sbjct: 107 NNELETIPNLGPVSA-NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISEL 160



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 35/132 (26%), Positives = 54/132 (40%), Gaps = 24/132 (18%)

Query: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120
           G + SL +     +++ D  F  L ++++L L+ N+ T I      GL  L+ L +  N 
Sbjct: 239 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA 298

Query: 121 IETISRNA------------------------FRGLRDLTHLSLANNHIKALPRDVFSDL 156
           I  IS +A                        F GL  L  L + NN +  +    F  L
Sbjct: 299 INRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 358

Query: 157 DSLIELDLRGNK 168
            SL  LDL+ N+
Sbjct: 359 SSLKTLDLKNNE 370



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 38/126 (30%), Positives = 50/126 (39%), Gaps = 25/126 (19%)

Query: 66  LSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSF------------------------TIIR 101
           L L     S I  +MF  LP LQ L LN N                          T + 
Sbjct: 197 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 255

Query: 102 DDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIE 161
           D AF GL ++E L ++ N +  I++    GL  L  L L+ N I  +  D +     L E
Sbjct: 256 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 315

Query: 162 LDLRGN 167
           LDL  N
Sbjct: 316 LDLTFN 321


>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
           isoform 1 [Homo sapiens]
          Length = 1059

 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 60/201 (29%), Positives = 97/201 (48%), Gaps = 7/201 (3%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDD---AFAGLFHLEYLFIEGN 119
           +++L + N   S I D  F  L SL+ L L +N  +   +D   AF+GL  L  L ++GN
Sbjct: 277 LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 336

Query: 120 KIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLY 179
           +I +I++ AF GL  L HL L++N I +L  + FS +  L +L L  +   CDC+ KWL 
Sbjct: 337 RIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLP 396

Query: 180 LWLKMTN-STVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNS 238
            W+   N  +  +  C  P   + + +  V+   + C   DF   Q +  Q  +      
Sbjct: 397 QWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVC--DDFPKPQ-ITVQPETQSAIKG 453

Query: 239 KNDVYVAIAQPSMENCMVLEW 259
            N  ++  A  S ++ M   W
Sbjct: 454 SNLSFICSAASSSDSPMTFAW 474



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 36/113 (31%), Positives = 56/113 (49%), Gaps = 4/113 (3%)

Query: 59  VPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEG 118
           V  +I+ LSL      EI         SL+ L L+SN+ + ++  AF  L  L+YL++  
Sbjct: 59  VSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ-TAFPAL-QLKYLYLNS 116

Query: 119 NKIETISRNAFRGLRD-LTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFE 170
           N++ ++    F  L + L  L L  N I A+P  +F  L  L  L+L  NK +
Sbjct: 117 NRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIK 168



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 35/132 (26%), Positives = 54/132 (40%), Gaps = 24/132 (18%)

Query: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120
           G + SL +     +++ D  F  L ++++L L+ N+ T I      GL  L+ L +  N 
Sbjct: 179 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA 238

Query: 121 IETISRNA------------------------FRGLRDLTHLSLANNHIKALPRDVFSDL 156
           I  IS +A                        F GL  L  L + NN +  +    F  L
Sbjct: 239 INRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 298

Query: 157 DSLIELDLRGNK 168
            SL  LDL+ N+
Sbjct: 299 SSLKTLDLKNNE 310



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 38/126 (30%), Positives = 50/126 (39%), Gaps = 25/126 (19%)

Query: 66  LSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSF------------------------TIIR 101
           L L     S I  +MF  LP LQ L LN N                          T + 
Sbjct: 137 LKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLM 195

Query: 102 DDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIE 161
           D AF GL ++E L ++ N +  I++    GL  L  L L+ N I  +  D +     L E
Sbjct: 196 DGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE 255

Query: 162 LDLRGN 167
           LDL  N
Sbjct: 256 LDLTFN 261



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 26/86 (30%), Positives = 40/86 (46%), Gaps = 1/86 (1%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIE 122
           IS   L +   S IK    SHL SL+ + LN+N    I +       ++  L + GN+I 
Sbjct: 16  ISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA-NITLLSLAGNRIV 74

Query: 123 TISRNAFRGLRDLTHLSLANNHIKAL 148
            I     +  + L  L L++N+I  L
Sbjct: 75  EILPEHLKEFQSLETLDLSSNNISEL 100



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 1/76 (1%)

Query: 92  LNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRD 151
           L+ N  + I+  + + L  L  + +  N++ETI  N      ++T LSLA N I  +  +
Sbjct: 21  LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGNRIVEILPE 79

Query: 152 VFSDLDSLIELDLRGN 167
              +  SL  LDL  N
Sbjct: 80  HLKEFQSLETLDLSSN 95


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 72/244 (29%), Positives = 104/244 (42%), Gaps = 30/244 (12%)

Query: 1   MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGS--SWVPRI 58
           MA R  G G   LL L+L  A         +  A CP+ C C + ++ C+      VP +
Sbjct: 1   MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAV 60

Query: 59  VPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEG 118
            P   S L L      EI+   F  L +L  LLLN+N    I   AF  L +L+YL++  
Sbjct: 61  AP-QTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYK 119

Query: 119 NKIETISRNAFRGLRDLTHLSLANNHIKALPRD------------------------VFS 154
           N+I++I R AF+GL  L  L L  N I+ L  D                         F+
Sbjct: 120 NEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFN 179

Query: 155 DLDSLIELDLRGNKFECDCKAKWLYLWLKM---TNSTVSDVLCIGPPEYQEKKLNDVTSF 211
            L+S+  L L  N   CDC+  WL   LK    + +  +  +C  P   Q + +  +T  
Sbjct: 180 HLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPE 239

Query: 212 DYEC 215
           +  C
Sbjct: 240 ELNC 243


>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
           [Homo sapiens]
          Length = 1093

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 62/202 (30%), Positives = 100/202 (49%), Gaps = 9/202 (4%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDD---AFAGLFHLEYLFIEGN 119
           +S L L + + S I +  F  L SL++L L+ N  +   +D   AF+GL  L  L + GN
Sbjct: 333 LSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGN 392

Query: 120 KIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLY 179
           KI+++++ AF GL  L HL+L  N I+++  D F  + +L EL +  + F CDC+ KWL 
Sbjct: 393 KIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLP 452

Query: 180 LWL--KMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFN 237
            WL  +M  + V+   C  P   + + +  V    + C   DF+  Q +  Q  +     
Sbjct: 453 PWLIGRMLQAFVT-ATCAHPESLKGQSIFSVPPESFVC--DDFLKPQIIT-QPETTMAMV 508

Query: 238 SKNDVYVAIAQPSMENCMVLEW 259
            K+  +   A  S  + M   W
Sbjct: 509 GKDIRFTCSAASSSSSPMTFAW 530



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 57/172 (33%), Positives = 81/172 (47%), Gaps = 11/172 (6%)

Query: 5   RGGCGALG----LLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIICVGSSWVPRIVP 60
           RGG GA      LLLL L    L P +A     A C A C+C  +S+ C G       +P
Sbjct: 6   RGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAA--LP 63

Query: 61  GDISS----LSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFI 116
           GD+ S    L+L     SEI    F  LP+LQ + LN+N  T +     A   H+  LF+
Sbjct: 64  GDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFL 122

Query: 117 EGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNK 168
           + NKI ++  +  +    L  L L+ N+I  +    F     + EL+L GN+
Sbjct: 123 QHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNR 174



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 33/115 (28%), Positives = 49/115 (42%), Gaps = 1/115 (0%)

Query: 65  SLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETI 124
           +L L     +++  R F  LP L  L LN N   +I    F GL  LE L ++ N I  +
Sbjct: 192 TLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250

Query: 125 SRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLY 179
           +  AF GL  +  L L  N +  +       L +L +L L  N      +  W +
Sbjct: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSF 305


>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
           sapiens]
          Length = 674

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 59/192 (30%), Positives = 89/192 (46%), Gaps = 26/192 (13%)

Query: 53  SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTI--IRDDAFAGL-- 108
           S +P  +P  +  L L +   S I    F  L SL+ L+L+ N      I DD F+ L  
Sbjct: 190 SSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQN 249

Query: 109 --------------------FHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKAL 148
                                HL+ L+++ N I  I  N    +R+L  L L+NN++  L
Sbjct: 250 LTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTL 309

Query: 149 PRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQEKKLN 206
           PR +F DL +L +L LR N + C C   WL  W+K   + V+   ++C GP + +   + 
Sbjct: 310 PRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIK 369

Query: 207 DVTSFDYECTTT 218
           D+TS   EC  T
Sbjct: 370 DITSEMDECFET 381



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 42/150 (28%), Positives = 67/150 (44%), Gaps = 26/150 (17%)

Query: 36  CPATCSCTKESIIC--VGSSWVPRIVPGDISSLSLVN------GTFSEIK---------- 77
           CP+ C C    I C   G + +P  +P D ++L L N      G   ++K          
Sbjct: 54  CPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYL 113

Query: 78  -----DRMFSHLP-SLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETIS--RNAF 129
                D    +LP SL+ L L  N+   I  D+ A +  LE L ++ N + T+S   +AF
Sbjct: 114 YENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAF 173

Query: 130 RGLRDLTHLSLANNHIKALPRDVFSDLDSL 159
              + L  L L+ NH+ ++P  +   L+ L
Sbjct: 174 ADSKQLKLLFLSRNHLSSIPSGLPHTLEEL 203



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 43/137 (31%), Positives = 61/137 (44%), Gaps = 25/137 (18%)

Query: 56  PRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTI--IRDDAFA------- 106
           P  +P  +  L L +     I     + +P L+ L L+ NS +   I +DAFA       
Sbjct: 122 PINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKL 181

Query: 107 -------------GLFH-LEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHI--KALPR 150
                        GL H LE L ++ N+I TI  +AF+GL  L  L L  N +  + +  
Sbjct: 182 LFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANQRIAD 241

Query: 151 DVFSDLDSLIELDLRGN 167
           D FS L +L EL L  N
Sbjct: 242 DTFSRLQNLTELSLVRN 258


>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
           [Homo sapiens]
          Length = 1065

 Score = 83.2 bits (204), Expect = 6e-16
 Identities = 64/201 (31%), Positives = 95/201 (47%), Gaps = 8/201 (3%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDA---FAGLFHLEYLFIEGN 119
           +  L+L +   + I D +F  L +LQ L L +N  +   +DA   FAGL  L  L ++GN
Sbjct: 337 LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN 396

Query: 120 KIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLY 179
           +I++I++ AF GL  L HL L NN I ++  + FS    L EL L  +   CDC  KWL 
Sbjct: 397 QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ-THLKELILNTSSLLCDCHLKWLL 455

Query: 180 LWLKMTNSTVS-DVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFNS 238
            WL   N   S +V C  P     + + +V   D+ C   DF+  Q   +   ++     
Sbjct: 456 QWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC--DDFLKPQIRTHPE-TIIALRG 512

Query: 239 KNDVYVAIAQPSMENCMVLEW 259
            N      A  S ++ M   W
Sbjct: 513 MNVTLTCTAVSSSDSPMSTVW 533



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 31/103 (30%), Positives = 51/103 (49%)

Query: 66  LSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETIS 125
           L L       ++   F  L SL+ L +  N  + ++D AF GL ++E L +E N +  ++
Sbjct: 220 LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN 279

Query: 126 RNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNK 168
           +    GLR L  L ++ N I+ +  D +     L ELDL  N+
Sbjct: 280 KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQ 322



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 39/131 (29%), Positives = 65/131 (49%), Gaps = 6/131 (4%)

Query: 50  VGSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLL-LNSNSFTIIRDDAFAGL 108
           + +S  PR+    +  L+L N   + ++   F +L S  L++ LN N  ++I    F  L
Sbjct: 159 IKTSSFPRM---QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-L 214

Query: 109 FHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNK 168
            HL++L ++ N+I+ +    F+GL  L  L +  N I  L    F  L+++ EL+L  N 
Sbjct: 215 PHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274

Query: 169 FECDCKAKWLY 179
                K  WLY
Sbjct: 275 LTRVNKG-WLY 284



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 37/130 (28%), Positives = 56/130 (43%), Gaps = 24/130 (18%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIE 122
           + SL +     S++KD  F  L +++ L L  N+ T +      GL  L+ L++  N IE
Sbjct: 241 LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIE 300

Query: 123 TIS------------------------RNAFRGLRDLTHLSLANNHIKALPRDVFSDLDS 158
            IS                         +AF GL  L  L+L +N +  +   VF  L +
Sbjct: 301 RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN 360

Query: 159 LIELDLRGNK 168
           L  LDLR N+
Sbjct: 361 LQTLDLRNNE 370



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 33/110 (30%), Positives = 56/110 (50%), Gaps = 3/110 (2%)

Query: 62  DISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKI 121
           +I+ LSLV+    EI  +     P+L+ L L+SN  + I+  +F  +  L+YL +  N+I
Sbjct: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179

Query: 122 ETISRNAFRGL-RDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFE 170
            T+    F  L   L  + L  N +  +P  +F  L  L  L+L+ N+ +
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIK 228


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 62/209 (29%), Positives = 88/209 (42%), Gaps = 30/209 (14%)

Query: 36  CPATCSCTKESIICVGS--SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLN 93
           CP+ C C K ++ C+      +P+ VP   + L L      EI    F  L +L  LLLN
Sbjct: 24  CPSRCLCFKSTVRCMHLMLDHIPQ-VPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLN 82

Query: 94  SNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLS-------------- 139
           +N    I  +AF GL +L YL++  N+I  + +  F+GL  L HL               
Sbjct: 83  NNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETF 142

Query: 140 ----------LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLK---MTN 186
                     L NN +  +P   FS+LDSL  L L  N   CDC   WL   L+      
Sbjct: 143 GDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHG 202

Query: 187 STVSDVLCIGPPEYQEKKLNDVTSFDYEC 215
            T +   C  P     + +  VT  ++ C
Sbjct: 203 HTQAAATCEYPRRLHGRAVASVTVEEFNC 231


>gi|51317373 netrin-G1 ligand [Homo sapiens]
          Length = 640

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 50/176 (28%), Positives = 90/176 (51%), Gaps = 17/176 (9%)

Query: 57  RIVPGDISSLSLVN-GTFSEIKDRMFSHL--------PSLQLLL------LNSNSFTIIR 101
           R+  G++  LS ++ G F  + +  + +L        P+L  L+      L+ N  + IR
Sbjct: 176 RLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIR 235

Query: 102 DDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIE 161
             +F GL HL+ L++  ++I+ I RNAF  L+ L  ++LA+N++  LP D+F+ L  L  
Sbjct: 236 PGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLER 295

Query: 162 LDLRGNKFECDCKAKWLYLWLK--MTNSTVSDVLCIGPPEYQEKKLNDVTSFDYEC 215
           + L  N + C+C   WL  W+K    ++T     C  PP  + + + ++    + C
Sbjct: 296 IHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351



 Score = 73.9 bits (180), Expect = 3e-13
 Identities = 57/158 (36%), Positives = 80/158 (50%), Gaps = 10/158 (6%)

Query: 13  LLLLLLGAACLIPRSAQVRRLARCPATCSCTKE--SIICVGSSWVPRIVPGDISS----L 66
           LL++LL    L+   A + R   CP+ CSC+ +   +ICV  +   R VP  IS+    L
Sbjct: 26  LLVVLLALQLLVV--AGLVRAQTCPSVCSCSNQFSKVICVRKNL--REVPDGISTNTRLL 81

Query: 67  SLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISR 126
           +L       IK   F HL  L++L L+ N    I   AF GL +L  L +  N++ TI  
Sbjct: 82  NLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPN 141

Query: 127 NAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDL 164
            AF  L  L  L L NN I+++P   F+ + SL  LDL
Sbjct: 142 GAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDL 179


>gi|40217825 slit and trk like 6 [Homo sapiens]
          Length = 841

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 58/194 (29%), Positives = 89/194 (45%), Gaps = 29/194 (14%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIE 122
           +  L L N     +++  F +L  LQ L LN N  T +    F GL +LEYL++E N I+
Sbjct: 389 LEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLSKGMFLGLHNLEYLYLEYNAIK 448

Query: 123 TISRNAFRGLRDLTHLSLANNHIKALPRDVFS------------------------DLDS 158
            I    F  +  L  L L NN ++ LP  +FS                        DLD 
Sbjct: 449 EILPGTFNPMPKLKVLYLNNNLLQVLPPHIFSGVPLTKVNLKTNQFTHLPVSNILDDLDL 508

Query: 159 LIELDLRGNKFECDCKAKWLYLWL-KMTNSTVS-DVLCIGPPEYQEKKLNDVTSFDYECT 216
           L ++DL  N ++C C    L  W+ K++ +TV+ D+LC  P    +K+L  + S   E  
Sbjct: 509 LTQIDLEDNPWDCSCDLVGLQQWIQKLSKNTVTDDILCTSPGHLDKKELKALNS---EIL 565

Query: 217 TTDFVVHQTLPYQS 230
               V + ++P Q+
Sbjct: 566 CPGLVNNPSMPTQT 579



 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 53/184 (28%), Positives = 90/184 (48%), Gaps = 5/184 (2%)

Query: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120
           G +  L + + +   +K+  F  L +L+ L  ++N  T+I   AF+ L  L+ L +  N 
Sbjct: 112 GLLKQLHINHNSLEILKEDTFHGLENLEFLQADNNFITVIEPSAFSKLNRLKVLILNDNA 171

Query: 121 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSD-LDSLIELDLRGNKFECDCKAKWLY 179
           IE++  N FR +  LTHL L  N ++ LP   F + +  +++L L  NK+ C+C    L 
Sbjct: 172 IESLPPNIFRFV-PLTHLDLRGNQLQTLPYVGFLEHIGRILDLQLEDNKWACNCDLLQLK 230

Query: 180 LWLK--MTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLPYQSVSVDTFN 237
            WL+     S + DV+C  PP ++   L+ +   +  C T         P  S+ +   +
Sbjct: 231 TWLENMPPQSIIGDVVCNSPPFFKGSILSRLKK-ESICPTPPVYEEHEDPSGSLHLAATS 289

Query: 238 SKND 241
           S ND
Sbjct: 290 SIND 293



 Score = 36.6 bits (83), Expect = 0.061
 Identities = 24/78 (30%), Positives = 34/78 (43%)

Query: 90  LLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALP 149
           L+L  N    +        F LE L +  N+IE +   +F  L  L  L L  NH+  L 
Sbjct: 368 LILAGNIIHSLMKSDLVEYFTLEMLHLGNNRIEVLEEGSFMNLTRLQKLYLNGNHLTKLS 427

Query: 150 RDVFSDLDSLIELDLRGN 167
           + +F  L +L  L L  N
Sbjct: 428 KGMFLGLHNLEYLYLEYN 445


>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
           sapiens]
          Length = 660

 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 56/192 (29%), Positives = 88/192 (45%), Gaps = 26/192 (13%)

Query: 53  SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTI--IRDDAFAGLF- 109
           S VP  +P D+  L +     + I D  F +L SL+ L+++ N  T   I +  F+ L  
Sbjct: 172 SSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTK 231

Query: 110 ---------------------HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKAL 148
                                HL  L+++ N+I  I   AF  LR L  L ++NN ++ L
Sbjct: 232 LKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRML 291

Query: 149 PRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNST--VSDVLCIGPPEYQEKKLN 206
            + VF +L +L +L  R N + CDC  KW+  WLK   S+  V   +C GP + +   + 
Sbjct: 292 TQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVR 351

Query: 207 DVTSFDYECTTT 218
           ++      C TT
Sbjct: 352 ELNMNLLSCPTT 363



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 43/158 (27%), Positives = 66/158 (41%), Gaps = 26/158 (16%)

Query: 28  AQVRRLARCPATCSCTKESIICVGSSW--VPRIVPGDISSLSLVNG-------------- 71
           +QV +L  CP+ C C +  + C   S   VP  +P  ++ L L N               
Sbjct: 28  SQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNV 87

Query: 72  -------TFSEIKDRMFSHLP-SLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIET 123
                   +    D    +LP ++++L L  N+   I   A A L  LE L ++ N I T
Sbjct: 88  QSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSIST 147

Query: 124 --ISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSL 159
             +   AFR    L  L L+ NH+ ++P  +  DL  L
Sbjct: 148 VGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQEL 185


>gi|40217823 SLIT and NTRK-like family, member 5 [Homo sapiens]
          Length = 958

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 27/194 (13%)

Query: 66  LSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETIS 125
           L L N   S I+DR F  L +L+ L LN N    +  + F GL  L+YLF++ N I  I 
Sbjct: 438 LHLGNNRISMIQDRAFGDLTNLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQ 497

Query: 126 RNAFRGLRDLTHLSLANNHIKALPRDVFS------------------------DLDSLIE 161
              F  + +L  L L NN ++A+P  VFS                         L SLI+
Sbjct: 498 SGTFDPVPNLQLLFLNNNLLQAMPSGVFSGLTLLRLNLRSNHFTSLPVSGVLDQLKSLIQ 557

Query: 162 LDLRGNKFECDCKAKWLYLWLKM--TNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTD 219
           +DL  N ++C C    + LW++       V +V+C  P ++ E  +  + S +  C    
Sbjct: 558 IDLHDNPWDCTCDIVGMKLWVEQLKVGVLVDEVICKAPKKFAETDMRSIKS-ELLCPDYS 616

Query: 220 FVVHQTLPYQSVSV 233
            VV  T    S+ V
Sbjct: 617 DVVVSTPTPSSIQV 630



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 54/172 (31%), Positives = 78/172 (45%), Gaps = 26/172 (15%)

Query: 64  SSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIET 123
           S L L +    +I+   F  L  L+ L LN+N   ++RDD F GL +LEYL ++ N I  
Sbjct: 108 SILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFLGLENLEYLQVDYNYISV 167

Query: 124 ISRNAFRGLR-----------------------DLTHLSLANNHIKALPR-DVFSDLDSL 159
           I  NAF  L                         LTHL L  N +K LP   +   +D +
Sbjct: 168 IEPNAFGKLHLLQVLILNDNLLSSLPNNLFRFVPLTHLDLRGNRLKLLPYVGLLQHMDKV 227

Query: 160 IELDLRGNKFECDCKAKWLYLWLKMT--NSTVSDVLCIGPPEYQEKKLNDVT 209
           +EL L  N + C C+   L  WL     ++ V DV+C  P     + L++V+
Sbjct: 228 VELQLEENPWNCSCELISLKDWLDSISYSALVGDVVCETPFRLHGRDLDEVS 279



 Score = 30.0 bits (66), Expect = 5.7
 Identities = 18/62 (29%), Positives = 27/62 (43%)

Query: 109 FHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNK 168
           F + +L + GN +  +  N F      + L L +N I+ +    F  L  L  L L  NK
Sbjct: 81  FPIYHLLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNK 140

Query: 169 FE 170
            E
Sbjct: 141 LE 142


>gi|38202222 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 52/195 (26%), Positives = 89/195 (45%), Gaps = 26/195 (13%)

Query: 53  SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSN----------------- 95
           S +P  +P  I  L L +   S I       L SL+ L+L+ N                 
Sbjct: 167 STIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVN 226

Query: 96  --SFTIIRDDAFAGLFHL-----EYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKAL 148
               +++R+   A   +L       L+++ N I  +  NAF  LR L  L ++NN++  L
Sbjct: 227 LTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL 286

Query: 149 PRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKM--TNSTVSDVLCIGPPEYQEKKLN 206
           P+ +F DLD++ +L LR N + C CK KW+  WL+       V  ++C  P + +   + 
Sbjct: 287 PQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIK 346

Query: 207 DVTSFDYECTTTDFV 221
           D+ +  ++C  +  V
Sbjct: 347 DLNAELFDCKDSGIV 361



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 37/140 (26%), Positives = 61/140 (43%), Gaps = 26/140 (18%)

Query: 36  CPATCSCTKESIICVGS--SWVPRIVPGDISSLSLVN------GTFSEIK---------- 77
           CP+ C C    I C     + +P  +P D ++L L N      G  S++K          
Sbjct: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYL 90

Query: 78  -----DRMFSHLPS-LQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETIS--RNAF 129
                D   ++LP  ++ L L  N+   I  D+ + + +LE L ++ N +  +S    AF
Sbjct: 91  YHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAF 150

Query: 130 RGLRDLTHLSLANNHIKALP 149
           R    L  L L+ NH+  +P
Sbjct: 151 RDSNYLRLLFLSRNHLSTIP 170


>gi|7019383 fibronectin leucine rich transmembrane protein 3
           precursor [Homo sapiens]
          Length = 649

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 52/195 (26%), Positives = 89/195 (45%), Gaps = 26/195 (13%)

Query: 53  SWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSN----------------- 95
           S +P  +P  I  L L +   S I       L SL+ L+L+ N                 
Sbjct: 167 STIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVN 226

Query: 96  --SFTIIRDDAFAGLFHL-----EYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKAL 148
               +++R+   A   +L       L+++ N I  +  NAF  LR L  L ++NN++  L
Sbjct: 227 LTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNL 286

Query: 149 PRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKM--TNSTVSDVLCIGPPEYQEKKLN 206
           P+ +F DLD++ +L LR N + C CK KW+  WL+       V  ++C  P + +   + 
Sbjct: 287 PQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIK 346

Query: 207 DVTSFDYECTTTDFV 221
           D+ +  ++C  +  V
Sbjct: 347 DLNAELFDCKDSGIV 361



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 37/140 (26%), Positives = 61/140 (43%), Gaps = 26/140 (18%)

Query: 36  CPATCSCTKESIICVGS--SWVPRIVPGDISSLSLVN------GTFSEIK---------- 77
           CP+ C C    I C     + +P  +P D ++L L N      G  S++K          
Sbjct: 31  CPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYL 90

Query: 78  -----DRMFSHLPS-LQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETIS--RNAF 129
                D   ++LP  ++ L L  N+   I  D+ + + +LE L ++ N +  +S    AF
Sbjct: 91  YHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAF 150

Query: 130 RGLRDLTHLSLANNHIKALP 149
           R    L  L L+ NH+  +P
Sbjct: 151 RDSNYLRLLFLSRNHLSTIP 170


>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
          Length = 441

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 54/187 (28%), Positives = 88/187 (47%), Gaps = 3/187 (1%)

Query: 51  GSSWVPRIVPGDISSLS---LVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAG 107
           G S +P  V G + SL    L +     ++D +F  L +L  L L+ N    +    F G
Sbjct: 136 GLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRG 195

Query: 108 LFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGN 167
           L +L+ L +  N+++ +   AF  LR LT L L NN +  L  +  + L +L  L L GN
Sbjct: 196 LVNLDRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGN 255

Query: 168 KFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYECTTTDFVVHQTLP 227
            ++C C+A+ L+ WL+    + S V C+ P     + L  + + D+   T     HQ   
Sbjct: 256 PWDCGCRARSLWEWLQRFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKS 315

Query: 228 YQSVSVD 234
           +   + D
Sbjct: 316 HTLTTTD 322



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 54/195 (27%), Positives = 81/195 (41%), Gaps = 41/195 (21%)

Query: 3   LRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSC--TKESIICVGSSW--VPRI 58
           LR+G C  L LLL+          +A++     CP  C C     ++ C   ++  +P  
Sbjct: 2   LRKGCCVELLLLLV----------AAELPLGGGCPRDCVCYPAPMTVSCQAHNFAAIPEG 51

Query: 59  VPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEG 118
           +P D   + L N     ++   FS  P++  L + SN+ T I    F G  HLE L +  
Sbjct: 52  IPVDSERVFLQNNRIGLLQPGHFS--PAMVTLWIYSNNITYIHPSTFEGFVHLEELDLGD 109

Query: 119 NK-------------------------IETISRNAFRGLRDLTHLSLANNHIKALPRDVF 153
           N+                         +  +    F GL  L +L L +NHI+ L  D+F
Sbjct: 110 NRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGGLHSLQYLYLQDNHIEYLQDDIF 169

Query: 154 SDLDSLIELDLRGNK 168
            DL +L  L L GNK
Sbjct: 170 VDLVNLSHLFLHGNK 184


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 51/178 (28%), Positives = 79/178 (44%), Gaps = 24/178 (13%)

Query: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120
           G + +L L      E+   +F  L +LQ L L  N+   + DD F  L +L +LF+ GN+
Sbjct: 130 GRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNR 189

Query: 121 IETISRNAFRGLRDLTHLSLANNHI------------------------KALPRDVFSDL 156
           I ++   AFRGL  L  L L  N +                         ALP +  + L
Sbjct: 190 ISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPL 249

Query: 157 DSLIELDLRGNKFECDCKAKWLYLWLKMTNSTVSDVLCIGPPEYQEKKLNDVTSFDYE 214
            +L  L L  N + CDC+A+ L+ WL+    + S+V C  P     + L  + + D +
Sbjct: 250 RALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCSLPQRLAGRDLKRLAANDLQ 307



 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 47/165 (28%), Positives = 64/165 (38%), Gaps = 30/165 (18%)

Query: 34  ARCPATCSCTKESIICV-----GSSWVPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQ 88
           A CP  C C  E  +       G   VP  +P     + L     S +    F    +L 
Sbjct: 25  APCPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNLT 84

Query: 89  LLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK-------------------------IET 123
           +L L+SN    I   AF GL  LE L +  N                          ++ 
Sbjct: 85  ILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQE 144

Query: 124 ISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNK 168
           +    FRGL  L +L L +N ++ALP D F DL +L  L L GN+
Sbjct: 145 LGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNR 189


>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
          Length = 713

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 43/134 (32%), Positives = 71/134 (52%), Gaps = 2/134 (1%)

Query: 84  LPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANN 143
           L  L+ L L+ N   +IR  +F GL  L  L++   ++ TI RNAF  L+ L  L+L++N
Sbjct: 228 LVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHN 287

Query: 144 HIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMT--NSTVSDVLCIGPPEYQ 201
           ++ +LP D+F+ L  L  + L  N + C+C   WL  WLK T  ++T     C  P   +
Sbjct: 288 NLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLK 347

Query: 202 EKKLNDVTSFDYEC 215
            + + ++    + C
Sbjct: 348 GRYIGELDQSHFTC 361



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 45/133 (33%), Positives = 65/133 (48%), Gaps = 4/133 (3%)

Query: 36  CPATCSCTKES--IICVGSSW--VPRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLL 91
           CP  CSC+ ++  +IC       VP  +P +   L+L       I+   F HL  L++L 
Sbjct: 57  CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQ 116

Query: 92  LNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRD 151
           L+ N    I   AF GL  L  L +  N++ T+   AF  L  L  L L NN I+++P  
Sbjct: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176

Query: 152 VFSDLDSLIELDL 164
            F+ + SL  LDL
Sbjct: 177 AFNRVPSLRRLDL 189


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 53/164 (32%), Positives = 78/164 (47%), Gaps = 9/164 (5%)

Query: 8   CGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTK-ESIICVG--SSWVPRIVPGDIS 64
           C  + LLL LL    L P       +  CP+ C C++ +++ C     + VPR VP D  
Sbjct: 2   CSRVPLLLPLLLLLALGPG------VQGCPSGCQCSQPQTVFCTARQGTTVPRDVPPDTV 55

Query: 65  SLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETI 124
            L +     + +    F+ LP LQLL L+ N    +    F  L +L  L +  N++  I
Sbjct: 56  GLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEI 115

Query: 125 SRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNK 168
           +   FRGLR L  L L  N I+ +    F  LD L+EL L+ N+
Sbjct: 116 TNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNE 159



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 48/197 (24%), Positives = 85/197 (43%), Gaps = 7/197 (3%)

Query: 62  DISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGN-K 120
           ++ +L L      ++ + +FS L +L  L ++ N    +      GL  L  L + GN +
Sbjct: 193 NVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGLTRLRLAGNTR 251

Query: 121 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL 180
           I  +      GL  L  L ++N  ++ALP D+      L  L    N F C C   W   
Sbjct: 252 IAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGP 311

Query: 181 WLKMTNSTVS---DVLCIGPPEYQEKKLNDVTSFDYEC--TTTDFVVHQTLPYQSVSVDT 235
           W++ ++ T++   +  C  PP+   + L ++   D+ C  TTT   V  T P        
Sbjct: 312 WVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTAL 371

Query: 236 FNSKNDVYVAIAQPSME 252
            +S    +++  +P+ E
Sbjct: 372 SSSLAPTWLSPTEPATE 388


>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
           sapiens]
          Length = 606

 Score = 75.9 bits (185), Expect = 9e-14
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 4/158 (2%)

Query: 62  DISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKI 121
           +++SLS+ N   S +    F HL  L  L L+ N  + I    F+ L  L+ L I G ++
Sbjct: 250 NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQL 309

Query: 122 ETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLW 181
            TI  ++F+GLR L  L+++ N ++ L  +VFS   +L  L +  N   CDC+  W+   
Sbjct: 310 RTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWILQR 369

Query: 182 LKMTNSTVSDVLCIGPPEYQEKKLND----VTSFDYEC 215
                      +C GP   +E+   D      SF + C
Sbjct: 370 QPTLQFGGQQPMCAGPDTIRERSFKDFHSTALSFYFTC 407



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 39/136 (28%), Positives = 64/136 (47%), Gaps = 4/136 (2%)

Query: 36  CPATCSCTKE--SIICVGSSWV--PRIVPGDISSLSLVNGTFSEIKDRMFSHLPSLQLLL 91
           CPA C C+ +  S+ C     +  P  +P +   L L       +    F   P L+ + 
Sbjct: 28  CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87

Query: 92  LNSNSFTIIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRD 151
           L+ N    +   AF  LF+L  L ++GN+++ +    F GL +LT L ++ N I  L   
Sbjct: 88  LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147

Query: 152 VFSDLDSLIELDLRGN 167
           +F DL +L  L++  N
Sbjct: 148 MFQDLHNLKSLEVGDN 163



 Score = 50.1 bits (118), Expect = 5e-06
 Identities = 33/104 (31%), Positives = 52/104 (50%)

Query: 62  DISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKI 121
           ++ SL L       +   +F+ L +L  L ++ N   I+ D  F  L +L+ L +  N +
Sbjct: 106 NLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDL 165

Query: 122 ETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLR 165
             IS  AF GL  L  L+L   ++ A+P +  S L SLI L L+
Sbjct: 166 VYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLK 209



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 29/103 (28%), Positives = 46/103 (44%)

Query: 62  DISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKI 121
           +++ L +       + D MF  L +L+ L +  N    I   AF+GL  LE L +E   +
Sbjct: 130 NLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNL 189

Query: 122 ETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDL 164
             +   A   LR L  L L + +I  +P   F  L  L  L++
Sbjct: 190 TAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEI 232



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 28/102 (27%), Positives = 49/102 (48%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNKIE 122
           +  + L +   + ++   F++L +L+ L L  N   ++    F GL +L  L I  NKI 
Sbjct: 83  LEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIV 142

Query: 123 TISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDL 164
            +    F+ L +L  L + +N +  +    FS L SL +L L
Sbjct: 143 ILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTL 184



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 24/128 (18%)

Query: 63  ISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIE----- 117
           +  L+L     + +     SHL SL  L L   +   +   AF  LFHL++L I+     
Sbjct: 179 LEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLL 238

Query: 118 -------------------GNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDS 158
                                 + T+   AF+ L  LTHL+L+ N I  +   +FSDL  
Sbjct: 239 DMMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIR 298

Query: 159 LIELDLRG 166
           L EL + G
Sbjct: 299 LQELHIVG 306


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 71/270 (26%), Positives = 99/270 (36%), Gaps = 68/270 (25%)

Query: 1   MALRRGGCGALGLLLLLLGAACLIPRSAQVRRLARCPATCSCTKESIIC----------- 49
           MALR      L LLLL L             R A CPA C C   ++ C           
Sbjct: 1   MALRAPALLPLLLLLLPL-------------RAAGCPAACRCYSATVECGALRLRVVPLG 47

Query: 50  ---------VGSSWVPRIVPGDISSLS------LVNGTFSEIKDRMFSHLPSLQLLLLNS 94
                    +  + + R+ PG ++ L+      L N +   ++   F   P L  L L S
Sbjct: 48  IPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTS 107

Query: 95  NSFTIIRDDAFAGLFHLEYLFIEGNK------------------------IETISRNAFR 130
           N    +R  AF GL  L  L++ GN+                        IE +   A  
Sbjct: 108 NRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALA 167

Query: 131 GLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLK-----MT 185
           GL  L  L L+ N +  + R+    L SL  L L  N + CDC   WL  W+K     + 
Sbjct: 168 GLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLL 227

Query: 186 NSTVSDVLCIGPPEYQEKKLNDVTSFDYEC 215
            S    ++C  PP    + L DV+     C
Sbjct: 228 TSRDRKIMCAEPPRLALQSLLDVSHSSLIC 257


>gi|116268101 leucine rich repeat containing 62 [Homo sapiens]
          Length = 820

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 42/143 (29%), Positives = 71/143 (49%), Gaps = 3/143 (2%)

Query: 61  GDISSLSLVNGTFSEIKDRMFSHLPSLQLLLLNSNSFTIIRDDAFAGLFHLEYLFIEGNK 120
           G+++ L+L     S I+D  F    SLQ+L L  N  + + +    G+  L++LF++ N 
Sbjct: 79  GNLTDLNLTKNEISYIEDGAFLGQSSLQVLQLGYNKLSNLTEGMLRGMSRLQFLFVQHNL 138

Query: 121 IETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYL 180
           IE ++  AF     L  + L++N +  L    F+ L SL+  +L GN F C+C       
Sbjct: 139 IEVVTPTAFSECPSLISIDLSSNRLSRLDGATFASLASLMVCELAGNPFNCECDLFGFLA 198

Query: 181 WLKMTNSTVSD---VLCIGPPEY 200
           WL + N+   +   + C  P E+
Sbjct: 199 WLVVFNNVTKNYDRLQCESPREF 221


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,513,050
Number of Sequences: 37866
Number of extensions: 812474
Number of successful extensions: 3083
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 172
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 1715
Number of HSP's gapped (non-prelim): 857
length of query: 545
length of database: 18,247,518
effective HSP length: 107
effective length of query: 438
effective length of database: 14,195,856
effective search space: 6217784928
effective search space used: 6217784928
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.