BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|210147457 intermediate filament family orphan 2 [Homo sapiens] (517 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|210147457 intermediate filament family orphan 2 [Homo sapiens] 1046 0.0 gi|18490978 intermediate filament family orphan isoform 2 [Homo ... 541 e-154 gi|89213250 intermediate filament family orphan isoform 4 [Homo ... 535 e-152 gi|89213247 intermediate filament family orphan isoform 3 [Homo ... 210 2e-54 gi|62414289 vimentin [Homo sapiens] 95 1e-19 gi|15618995 keratin 71 [Homo sapiens] 84 2e-16 gi|28173564 keratin 73 [Homo sapiens] 83 7e-16 gi|55749932 desmin [Homo sapiens] 79 1e-14 gi|148612803 keratin 6 irs4 [Homo sapiens] 78 2e-14 gi|21264345 peripherin [Homo sapiens] 78 2e-14 gi|109148552 keratin 3 [Homo sapiens] 76 6e-14 gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 76 8e-14 gi|119395754 keratin 5 [Homo sapiens] 75 1e-13 gi|4504919 keratin 8 [Homo sapiens] 73 7e-13 gi|153791158 keratin 75 [Homo sapiens] 72 1e-12 gi|119395750 keratin 1 [Homo sapiens] 71 2e-12 gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 70 4e-12 gi|109255249 keratin 4 [Homo sapiens] 70 5e-12 gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 69 8e-12 gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 69 8e-12 gi|15431310 keratin 14 [Homo sapiens] 69 1e-11 gi|67782365 keratin 7 [Homo sapiens] 69 1e-11 gi|14249342 internexin neuronal intermediate filament protein, a... 68 2e-11 gi|153791670 keratin 76 [Homo sapiens] 67 4e-11 gi|27477127 keratin 82 [Homo sapiens] 67 4e-11 gi|47132620 keratin 2 [Homo sapiens] 67 4e-11 gi|5031839 keratin 6A [Homo sapiens] 67 4e-11 gi|28372503 keratin 72 isoform 1 [Homo sapiens] 67 5e-11 gi|226246663 keratin 72 isoform 1 [Homo sapiens] 67 5e-11 gi|125628636 keratin 80 isoform a [Homo sapiens] 66 7e-11 >gi|210147457 intermediate filament family orphan 2 [Homo sapiens] Length = 517 Score = 1046 bits (2706), Expect = 0.0 Identities = 517/517 (100%), Positives = 517/517 (100%) Query: 1 MVNSLLFGEMALAFGCPPGGGGGGCPGGGGGGGGAGPGPSPVTAALRDDLGSNIHLLKGL 60 MVNSLLFGEMALAFGCPPGGGGGGCPGGGGGGGGAGPGPSPVTAALRDDLGSNIHLLKGL Sbjct: 1 MVNSLLFGEMALAFGCPPGGGGGGCPGGGGGGGGAGPGPSPVTAALRDDLGSNIHLLKGL 60 Query: 61 NVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPAPG 120 NVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPAPG Sbjct: 61 NVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPAPG 120 Query: 121 GGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGTIWSYTQVRRTGGGGVETVQG 180 GGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGTIWSYTQVRRTGGGGVETVQG Sbjct: 121 GGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGTIWSYTQVRRTGGGGVETVQG 180 Query: 181 PGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTL 240 PGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTL Sbjct: 181 PGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTL 240 Query: 241 QEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDI 300 QEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDI Sbjct: 241 QEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDI 300 Query: 301 TAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDE 360 TAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDE Sbjct: 301 TAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDE 360 Query: 361 MKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHET 420 MKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHET Sbjct: 361 MKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHET 420 Query: 421 ESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGS 480 ESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGS Sbjct: 421 ESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGS 480 Query: 481 ADRNSPSPSSVASSDSGSTDEIQDEFEREADVEPMVS 517 ADRNSPSPSSVASSDSGSTDEIQDEFEREADVEPMVS Sbjct: 481 ADRNSPSPSSVASSDSGSTDEIQDEFEREADVEPMVS 517 >gi|18490978 intermediate filament family orphan isoform 2 [Homo sapiens] Length = 559 Score = 541 bits (1393), Expect = e-154 Identities = 313/537 (58%), Positives = 371/537 (69%), Gaps = 37/537 (6%) Query: 6 LFGEMALAFGCPPGGGGGGCP------GGGGGGGGAGPGPSPVTA-ALRDDLGSNIHLLK 58 L G + + G GGG P G GPGP+P A ALR+DLGSNI++LK Sbjct: 19 LAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAMALRNDLGSNINVLK 78 Query: 59 GLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPA 118 LN+RFRCFLAKVHELERRNRLLEKQL QQ E ++ R R+QAVQTG + P Sbjct: 79 TLNLRFRCFLAKVHELERRNRLLEKQL-QQALEEGKQGRRGLGRRDQAVQTG--FVSPIR 135 Query: 119 PGG--------------GHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGR----LPGT 160 P G L S A + A A + L S Y +PGT Sbjct: 136 PLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTSTSTTYSSSARFMPGT 195 Query: 161 IWSYTQVRRTGGGGVET-VQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 219 IWS++ RR G G T VQGPG+SWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY Sbjct: 196 IWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 255 Query: 220 KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDL 279 KRRWEEE R+ LQ V+ LQE AQEADA QEE+ K+E+LKAELVVFKGLMS+ +++L Sbjct: 256 KRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVFKGLMSNNLSEL 315 Query: 280 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVP---KKKERKVASDDD 336 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRN ED+ ++FQV +K+ERK A ++D Sbjct: 316 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGRKRERKAAVEED 375 Query: 337 ISEQDGEVNRFSD---DEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLLW 393 S + E R D +E +++I +EM+RM NQLRE +DF+DDCDSLTWEE E+TLLLW Sbjct: 376 TSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLRE-YDFEDDCDSLTWEETEETLLLW 434 Query: 394 EDFTN-CNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRH 452 EDF+ + QGEQE++L +I +TES FKTR+KEYQETI QIELELATAK+DMNRH Sbjct: 435 EDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKNDMNRH 494 Query: 453 LHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGSTDEIQDEFERE 509 LHEYMEMCSMKRGLDVQMETCRRLI S DR SP+ ++V SD ++ +R+ Sbjct: 495 LHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSEAEDSDRD 551 >gi|89213250 intermediate filament family orphan isoform 4 [Homo sapiens] Length = 563 Score = 535 bits (1378), Expect = e-152 Identities = 314/541 (58%), Positives = 373/541 (68%), Gaps = 41/541 (7%) Query: 6 LFGEMALAFGCPPGGGGGGCP------GGGGGGGGAGPGPSPVTA-ALRDDLGSNIHLLK 58 L G + + G GGG P G GPGP+P A ALR+DLGSNI++LK Sbjct: 19 LAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAMALRNDLGSNINVLK 78 Query: 59 GLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGPELLRPPA 118 LN+RFRCFLAKVHELERRNRLLEKQL QQ E ++ R R+QAVQTG + P Sbjct: 79 TLNLRFRCFLAKVHELERRNRLLEKQL-QQALEEGKQGRRGLGRRDQAVQTG--FVSPIR 135 Query: 119 PGG--------------GHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGR----LPGT 160 P G L S A + A A + L S Y +PGT Sbjct: 136 PLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTSTSTTYSSSARFMPGT 195 Query: 161 IWSYTQVRRTGGGGVET-VQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 219 IWS++ RR G G T VQGPG+SWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY Sbjct: 196 IWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 255 Query: 220 KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDL 279 KRRWEEE R+ LQ V+ LQE AQEADA QEE+ K+E+LKAELVVFKGLMS+ +++L Sbjct: 256 KRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVFKGLMSNNLSEL 315 Query: 280 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQ--VVP----KKKERKVAS 333 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRN ED+ ++FQ +VP +K+ERK A Sbjct: 316 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQKKLVPSMGGRKRERKAAV 375 Query: 334 DDDISEQDGEVNRFSD---DEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTL 390 ++D S + E R D +E +++I +EM+RM NQLRE +DF+DDCDSLTWEE E+TL Sbjct: 376 EEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLRE-YDFEDDCDSLTWEETEETL 434 Query: 391 LLWEDFTN-CNPTIDLQGE-QEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSD 448 LLWEDF+ + QGE QE++L +I +TES FKTR+KEYQETI QIELELATAK+D Sbjct: 435 LLWEDFSGYAMAAAEAQGEQQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKND 494 Query: 449 MNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGSTDEIQDEFER 508 MNRHLHEYMEMCSMKRGLDVQMETCRRLI S DR SP+ ++V SD ++ +R Sbjct: 495 MNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSEAEDSDR 554 Query: 509 E 509 + Sbjct: 555 D 555 >gi|89213247 intermediate filament family orphan isoform 3 [Homo sapiens] Length = 200 Score = 210 bits (535), Expect = 2e-54 Identities = 112/190 (58%), Positives = 141/190 (74%), Gaps = 6/190 (3%) Query: 325 KKKERKVASDDDISEQDGEVNRFSD---DEVGSMNITDEMKRMFNQLRETFDFDDDCDSL 381 +K+ERK A ++D S + E R D +E +++I +EM+RM NQLRE +DF+DDCDSL Sbjct: 4 RKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLRE-YDFEDDCDSL 62 Query: 382 TWEENEDTLLLWEDFTN-CNPTIDLQGEQEEN-LGNLIHETESFFKTRDKEYQETIGQIE 439 TWEE E+TLLLWEDF+ + QGEQ+E+ L +I +TES FKTR+KEYQETI QIE Sbjct: 63 TWEETEETLLLWEDFSGYAMAAAEAQGEQQEDSLEKVIKDTESLFKTREKEYQETIDQIE 122 Query: 440 LELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGST 499 LELATAK+DMNRHLHEYMEMCSMKRGLDVQMETCRRLI S DR SP+ ++V SD Sbjct: 123 LELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPP 182 Query: 500 DEIQDEFERE 509 ++ +R+ Sbjct: 183 PSEAEDSDRD 192 >gi|62414289 vimentin [Homo sapiens] Length = 466 Score = 95.1 bits (235), Expect = 1e-19 Identities = 77/297 (25%), Positives = 139/297 (46%), Gaps = 47/297 (15%) Query: 201 EIRALYNVLAKVKRERDEY-------KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 ++ L N A+V+ ERD + + +EE+ +R + + + ++ A + + Sbjct: 160 QVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLD 219 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K+E L+ E+ K L + + +L +IQE+ +++D+D+ + D+TA L DV QQ S Sbjct: 220 LERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKP-DLTAALRDVRQQYES 278 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 +K Q + + K A D+SE + N ++ R Q E+ + Sbjct: 279 V-AAKNLQEAEEWYKSKFA---DLSE--------------AANRNNDALRQAKQ--ESTE 318 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 + SLT E +D E+L + E E F YQ+ Sbjct: 319 YRRQVQSLTCE------------------VDALKGTNESLERQMREMEENFAVEAANYQD 360 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS-PSPS 489 TIG+++ E+ K +M RHL EY ++ ++K LD+++ T R+L++G R S P P+ Sbjct: 361 TIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPN 417 >gi|15618995 keratin 71 [Homo sapiens] Length = 523 Score = 84.3 bits (207), Expect = 2e-16 Identities = 74/311 (23%), Positives = 138/311 (44%), Gaps = 43/311 (13%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q++T++ + L + L V+ ++YK+R+EEE+ KR + L++ A A + E Sbjct: 191 QLETLSGDRVRLDSELRNVRDVVEDYKKRYEEEINKRTAAENEFVLLKKDVDAAYANKVE 250 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K+E + E+ F+ L +T + + I + ++ + MD R +D+ + + +V Q Sbjct: 251 LQAKVESMDQEIKFFRCLFEAEITQIQSHISDMSVILSMDNNRNLDLDSIIDEVRTQ--Y 308 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 E+++ + K E + E R DD + N E+ R+ ++R Sbjct: 309 EEIA-----LKSKAEAEALYQTKFQELQLAAGRHGDDLKNTKNEISELTRLIQRIRS--- 360 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 I+ +Q NL I + E K+ + Sbjct: 361 ----------------------------EIENVKKQASNLETAIADAEQRGDNALKDARA 392 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS---PSPSS 490 + ++E L AK ++ R L EY E+ S+K LD+++ T R+L++ R S PSP S Sbjct: 393 KLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLESEECRMSGEFPSPVS 452 Query: 491 VA--SSDSGST 499 ++ SS SG + Sbjct: 453 ISIISSTSGGS 463 >gi|28173564 keratin 73 [Homo sapiens] Length = 540 Score = 82.8 bits (203), Expect = 7e-16 Identities = 73/310 (23%), Positives = 133/310 (42%), Gaps = 44/310 (14%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q++T++ + L + L V+ ++YK+R+EEE+ KR + L++ A + E Sbjct: 193 QLETLSGDRVRLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLKKDVDAAYTSKVE 252 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K++ L E+ FK L + + I + ++ + MD R +D+ + + +V Q Sbjct: 253 LQAKVDALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDSIIAEVRAQY-- 310 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 E++++ K E + E R DD + N E+ R+ +LR Sbjct: 311 EEIAR-----KSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLRSE-- 363 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 I+ +Q NL I + E K+ + Sbjct: 364 -----------------------------IESVKKQCANLETAIADAEQRGDCALKDARA 394 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR------NSPS 487 + ++E L AK ++ R L EY E+ S+K LD+++ T R+L++G R NS S Sbjct: 395 KLDELEGALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVS 454 Query: 488 PSSVASSDSG 497 S + SS +G Sbjct: 455 ISVINSSMAG 464 Score = 36.2 bits (82), Expect = 0.074 Identities = 41/175 (23%), Positives = 84/175 (48%), Gaps = 24/175 (13%) Query: 193 VQIDTITPEIRALYNVLAKVKRERDE--YKRRWEE-ELAKRMNLQTMVDTLQEAAQEADA 249 + +D+I E+RA Y +A+ + E Y+ +++E +LA + + T E + Sbjct: 297 LDLDSIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEIS----- 351 Query: 250 IQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDV-- 307 E+ I+RL++E+ K +L+T I + + D C D AKL ++ Sbjct: 352 ---ELTRLIQRLRSEIESVK----KQCANLETAIADAEQRGD---CALKDARAKLDELEG 401 Query: 308 AQQRNSEDVSKIFQVVPKKKERKVASDDDISEQ----DGEVNRFSDDEVGSMNIT 358 A Q+ E+++++ + + K++ D +I+ +GE R S + S++I+ Sbjct: 402 ALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVSIS 456 >gi|55749932 desmin [Homo sapiens] Length = 470 Score = 78.6 bits (192), Expect = 1e-14 Identities = 67/290 (23%), Positives = 124/290 (42%), Gaps = 46/290 (15%) Query: 201 EIRALYNVLAKVKRERDEY-------KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 ++ L N A+V ERD K + +EE+ + + + + A + + Sbjct: 165 QVEVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARID 224 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + +IE L E+ K + + + +L ++QE+ ++V+MD+ + D+TA L D+ Q Sbjct: 225 LERRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKP-DLTAALRDIRAQ--- 280 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 ++ + K +ISE + D + N ++ R Q E + Sbjct: 281 ------YETIAAK---------NISEAEEWYKSKVSDLTQAANKNNDALRQAKQ--EMME 323 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 + S T E ID ++L + E E F + YQ+ Sbjct: 324 YRHQIQSYTCE------------------IDALKGTNDSLMRQMRELEDRFASEASGYQD 365 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR 483 I ++E E+ K +M RHL EY ++ ++K LDV++ T R+L++G R Sbjct: 366 NIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESR 415 >gi|148612803 keratin 6 irs4 [Homo sapiens] Length = 529 Score = 78.2 bits (191), Expect = 2e-14 Identities = 70/302 (23%), Positives = 137/302 (45%), Gaps = 39/302 (12%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q++T++ + L + L ++ ++YK+R+E E+ +R + L++ A A A++ E Sbjct: 201 QLETLSGDRVRLDSELRSMRDLVEDYKKRYEVEINRRTTAENEFVVLKKDADAAYAVKVE 260 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K++ L E+ K L + + T E ++ + MD R +D+ + + +V + + Sbjct: 261 LQAKVDSLDKEIKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIAEV--RMHY 318 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 E+++ + K E + I E +R DD + + E+ R+ ++R Sbjct: 319 EEIA-----LKSKAEAEALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIR---- 369 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 C+ I +Q +L I + E K+ Q Sbjct: 370 ----CE-----------------------IGNVKKQRASLETAIADAEQRGDNALKDAQA 402 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS-PSPSSVA 492 + ++E L AK ++ R L EY E+ S+K LD+++ T R+L++G R S +PSSV+ Sbjct: 403 KLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLEGEECRMSGENPSSVS 462 Query: 493 SS 494 S Sbjct: 463 IS 464 >gi|21264345 peripherin [Homo sapiens] Length = 470 Score = 78.2 bits (191), Expect = 2e-14 Identities = 81/314 (25%), Positives = 133/314 (42%), Gaps = 53/314 (16%) Query: 201 EIRALYNVLAKVKRERDEY--------------KRRWEEELAKRMNLQTMVDTLQEAAQE 246 E+R L L + RERD K+R EEE KR + + + ++ + Sbjct: 147 ELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDD 206 Query: 247 ADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQ-EKAMKVDMDICRRIDITAKLC 305 A + E+ KIE L E+ K L + + DL ++ ++ +V+++ + ++TA L Sbjct: 207 ATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALR 266 Query: 306 DVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMF 365 D+ Q S +K Q + + K A D + ++ E R + E+ +E +R Sbjct: 267 DIRAQYESI-AAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEM------NESRRQI 319 Query: 366 NQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFK 425 SLT E + L+G E L L E E F Sbjct: 320 Q-------------SLTCEVD-----------------GLRGTNEALLRQL-RELEEQFA 348 Query: 426 TRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS 485 YQ ++E EL K +M RHL EY E+ ++K LD+++ T R+L++G R S Sbjct: 349 LEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRIS 408 Query: 486 PSPSSVASSDSGST 499 S AS + +T Sbjct: 409 VPVHSFASLNIKTT 422 >gi|109148552 keratin 3 [Homo sapiens] Length = 628 Score = 76.3 bits (186), Expect = 6e-14 Identities = 69/308 (22%), Positives = 133/308 (43%), Gaps = 41/308 (13%) Query: 195 IDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEM 254 +D I E L + L ++ +++K+++E+E+ KR + TL++ A + E+ Sbjct: 262 LDNILGERGRLDSELKNMEDLVEDFKKKYEDEINKRTAAENEFVTLKKDVDSAYMNKVEL 321 Query: 255 NEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSE 314 K++ L E+ + L ++ + + I + ++ + MD R +D+ + + +V Q E Sbjct: 322 QAKVDALIDEIDFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIAEVRAQY--E 379 Query: 315 DVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDF 374 D+++ K E + + E R DD + + E+ RM +LR Sbjct: 380 DIAQ-----RSKAEAEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAE--- 431 Query: 375 DDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQET 434 I+ +Q NL I E E + K+ Sbjct: 432 ----------------------------IEGVKKQNANLQTAIAEAEQHGEMALKDANAK 463 Query: 435 IGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS---PSPSSV 491 + +++ L AK D+ R L +Y E+ ++K LDV++ T R+L++G R S PS S+ Sbjct: 464 LQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEEYRMSGECPSAVSI 523 Query: 492 ASSDSGST 499 + S +T Sbjct: 524 SVVSSSTT 531 Score = 40.0 bits (92), Expect = 0.005 Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 21/92 (22%) Query: 19 GGGGGGCPGGGGGGGGAGPGPSP-------VTAALRDDLGSNI------------HLLKG 59 G GG G PG G GG GPG P + +L L I +K Sbjct: 145 GSGGFGGPGSLGSPGGFGPGGFPGGIQEVTINQSLLQPLNVEIDPQIGQVKAQEREQIKT 204 Query: 60 LNVRFRCFLAKVHELERRNRLLEKQ--LEQQQ 89 LN +F F+ KV LE++N++LE + L QQQ Sbjct: 205 LNNKFASFIDKVRFLEQQNKVLETKWNLLQQQ 236 Score = 29.3 bits (64), Expect = 9.0 Identities = 15/29 (51%), Positives = 16/29 (55%) Query: 8 GEMALAFGCPPGGGGGGCPGGGGGGGGAG 36 G +G GGG GG G GGG GGAG Sbjct: 95 GGFGSGYGGGFGGGFGGGRGMGGGFGGAG 123 Score = 29.3 bits (64), Expect = 9.0 Identities = 17/39 (43%), Positives = 21/39 (53%), Gaps = 1/39 (2%) Query: 1 MVNSLLFGEMALAFGCPPGGG-GGGCPGGGGGGGGAGPG 38 +V+S A +G GGG GGG GG GGG+G G Sbjct: 525 VVSSSTTSASAGGYGGGYGGGMGGGLGGGFSAGGGSGSG 563 >gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo sapiens] Length = 916 Score = 75.9 bits (185), Expect = 8e-14 Identities = 72/310 (23%), Positives = 127/310 (40%), Gaps = 52/310 (16%) Query: 196 DTITPEIRALYNVLAKVKRERDEY--------------KRRWEEELAKRMNLQTMVDTLQ 241 D EIR L L V E+ + K R+EEE R + + + L+ Sbjct: 148 DAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALR 207 Query: 242 EAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDIT 301 + +EA ++ E+++K++ L+ E+ + + + DL +IQ + V+ + DI+ Sbjct: 208 KDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS 267 Query: 302 AKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEM 361 L ++ Q S + Q K R A + +EQ+ E R + +E+ E Sbjct: 268 TALKEIRSQLESHSDQNMHQAEEWFKCR-YAKLTEAAEQNKEAIRSAKEEIA------EY 320 Query: 362 KRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETE 421 +R S+ E T +E+L + + E Sbjct: 321 RRQLQS-----------KSIELESVRGT--------------------KESLERQLSDIE 349 Query: 422 SFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSA 481 YQ+TI Q+E EL K +M RHL EY ++ ++K LD+++ R+L++G Sbjct: 350 ERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEE 409 Query: 482 DRNSPSPSSV 491 R S S+ Sbjct: 410 TRFSTFAGSI 419 Score = 34.3 bits (77), Expect = 0.28 Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 5/54 (9%) Query: 33 GGAGPGPSPVTAALRDDLGSNIHLLKGLNVRFRCFLAKVHELERRNRLLEKQLE 86 GG+GPG + + L+GLN RF ++ KVH LE++N+ +E +++ Sbjct: 86 GGSGPGGDYKLSRSNEK-----EQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQ 134 >gi|119395754 keratin 5 [Homo sapiens] Length = 590 Score = 75.5 bits (184), Expect = 1e-13 Identities = 67/292 (22%), Positives = 123/292 (42%), Gaps = 38/292 (13%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q+D+I E L + L ++ +++K ++E+E+ KR + L++ A + E Sbjct: 229 QLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVE 288 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K++ L E+ K ++ + T + + ++ + MD R +D+ + + +V Q Sbjct: 289 LEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKAQY-- 346 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 E+++ + E + E R DD + + EM RM +LR Sbjct: 347 EEIAN-----RSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAE-- 399 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 ID +Q NL N I + E + K+ + Sbjct: 400 -----------------------------IDNVKKQCANLQNAIADAEQRGELALKDARN 430 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS 485 + ++E L AK DM R L EY E+ + K LDV++ T R+L++G R S Sbjct: 431 KLAELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLS 482 Score = 37.0 bits (84), Expect = 0.043 Identities = 32/114 (28%), Positives = 45/114 (39%), Gaps = 24/114 (21%) Query: 8 GEMALAFGCPPGGGGGGCPGGGGGGGGAGPGPS------------PVTAALRDDLGSNI- 54 G FG G GGG GGG G GG GP V +L L I Sbjct: 99 GGAGSGFGFGGGAGGGFGLGGGAGFGGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQID 158 Query: 55 -----------HLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLR 97 +K LN +F F+ KV LE++N++L+ + Q + + +R Sbjct: 159 PSIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVR 212 >gi|4504919 keratin 8 [Homo sapiens] Length = 483 Score = 72.8 bits (177), Expect = 7e-13 Identities = 66/324 (20%), Positives = 138/324 (42%), Gaps = 43/324 (13%) Query: 160 TIWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEY 219 T WS Q ++T ++ + ++ + Q++T+ E L L ++ +++ Sbjct: 121 TKWSLLQQQKTARSNMDNMFESYIN-----NLRRQLETLGQEKLKLEAELGNMQGLVEDF 175 Query: 220 KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTDL 279 K ++E+E+ KR ++ +++ EA + E+ ++E L E+ + L + + +L Sbjct: 176 KNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIREL 235 Query: 280 DTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISE 339 ++I + ++ + MD R +D+ + + +V Q ED++ + E + E Sbjct: 236 QSQISDTSVVLSMDNSRSLDMDSIIAEVKAQY--EDIAN-----RSRAEAESMYQIKYEE 288 Query: 340 QDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFTNC 399 + DD + EM R ++L+ + Sbjct: 289 LQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIE-------------------------- 322 Query: 400 NPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYMEM 459 L+G Q +L I + E + K+ + ++E L AK DM R L EY E+ Sbjct: 323 ----GLKG-QRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQEL 377 Query: 460 CSMKRGLDVQMETCRRLIKGSADR 483 ++K LD+++ T R+L++G R Sbjct: 378 MNVKLALDIEIATYRKLLEGEESR 401 Score = 45.4 bits (106), Expect = 1e-04 Identities = 91/390 (23%), Positives = 151/390 (38%), Gaps = 65/390 (16%) Query: 21 GGGGCPGGGGGGGGAGPGPSPVTAA---------LRDDLGSNIHL--------LKGLNVR 63 G GG GGG G G +TA L ++ NI +K LN + Sbjct: 42 GSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNK 101 Query: 64 FRCFLAKVHELERRNRLLEKQ---LEQQQSERERR----LRYKTFSREQAVQTGPELLRP 116 F F+ KV LE++N++LE + L+QQ++ R Y R Q G E L+ Sbjct: 102 FASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKL 161 Query: 117 PAP-GGGHGL-----------SSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGTIWSY 164 A G GL + N + + + + RL G Sbjct: 162 EAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEI 221 Query: 165 TQVRRTGGGGVETVQG----PGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDE-- 218 +R+ + +Q V + + +D+I E++A Y +A R E Sbjct: 222 NFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESM 281 Query: 219 YKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMTD 278 Y+ ++EE LQ++ + + EMN I RL+AE+ KG Sbjct: 282 YQIKYEE-------LQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKG----QRAS 330 Query: 279 LDTKIQEKAMKVDMDICRRIDITAKLCDV--AQQRNSEDVSKIFQVVPKKKERKVASDDD 336 L+ I + + ++ I D AKL ++ A QR +D+++ + + K+A D + Sbjct: 331 LEAAIADAEQRGELAI---KDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIE 387 Query: 337 ISEQ----DGEVNRFSDDEVGSMNITDEMK 362 I+ +GE +R E G N++ K Sbjct: 388 IATYRKLLEGEESRL---ESGMQNMSIHTK 414 >gi|153791158 keratin 75 [Homo sapiens] Length = 551 Score = 72.0 bits (175), Expect = 1e-12 Identities = 72/310 (23%), Positives = 129/310 (41%), Gaps = 43/310 (13%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q+++IT E L L ++ +++K R+E+E+ KR + L++ A + E Sbjct: 210 QLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVE 269 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K++ L E+ + ++ L T++ + ++ + MD R +D+ + + +V Q Sbjct: 270 LEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQY-- 327 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 ED++ + E + E R DD + EM RM +LR Sbjct: 328 EDIAN-----RSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAE-- 380 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 ID +Q +L I + E + K+ + Sbjct: 381 -----------------------------IDSVKKQCSSLQTAIADAEQRGELALKDARA 411 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKG-----SADRNSPSP 488 + +E L AK DM R L EY E+ ++K LDV++ T R+L++G S + SP Sbjct: 412 KLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVN 471 Query: 489 SSVASSDSGS 498 SV +S S Sbjct: 472 ISVVTSTLSS 481 Score = 34.7 bits (78), Expect = 0.22 Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 26/112 (23%) Query: 8 GEMALAFGCPPGGGGGGCPGGGGGGGGAGPG-----PSPV-TAALRDDLGSNIHL----- 56 G + FG G G GG G GGG +GP P + + L + +HL Sbjct: 86 GRASNRFGVNSGFGYGG----GVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPT 141 Query: 57 -----------LKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLR 97 +K LN +F F+ KV LE++N++LE + Q + R +R Sbjct: 142 IQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVR 193 >gi|119395750 keratin 1 [Homo sapiens] Length = 644 Score = 71.2 bits (173), Expect = 2e-12 Identities = 62/292 (21%), Positives = 121/292 (41%), Gaps = 38/292 (13%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 ++D + + L + L ++ ++Y+ ++E+E+ KR N + T+++ A + + Sbjct: 241 RVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVD 300 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K++ L+ E+ L ++ + T+I E + + MD R +D+ + + +V Q Sbjct: 301 LQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQ--Y 358 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 ED+++ K E + E R D S E+ R+ +LR Sbjct: 359 EDIAQ-----KSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRS--- 410 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 ID +Q NL I + E + K+ + Sbjct: 411 ----------------------------EIDNVKKQISNLQQSISDAEQRGENALKDAKN 442 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNS 485 + +E L AK D+ R L +Y E+ + K LD+++ T R L++G R S Sbjct: 443 KLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMS 494 Score = 44.7 bits (104), Expect = 2e-04 Identities = 33/95 (34%), Positives = 44/95 (46%), Gaps = 19/95 (20%) Query: 14 FGCPPGGGGGGCPGGGGGGGGAGPGPSP-------VTAALRDDLGSNI------------ 54 FG GG GGG GGGG GGG GP P + +L L I Sbjct: 122 FGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSRER 181 Query: 55 HLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQ 89 +K LN +F F+ KV LE++N++L+ + E Q Sbjct: 182 EQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQ 216 Score = 32.7 bits (73), Expect = 0.82 Identities = 13/20 (65%), Positives = 14/20 (70%) Query: 19 GGGGGGCPGGGGGGGGAGPG 38 GGGGGG GG G GGG+ G Sbjct: 592 GGGGGGSSGGRGSGGGSSGG 611 Score = 32.0 bits (71), Expect = 1.4 Identities = 14/20 (70%), Positives = 14/20 (70%) Query: 19 GGGGGGCPGGGGGGGGAGPG 38 G GGGG GGG GGGG G G Sbjct: 98 GFGGGGFGGGGFGGGGIGGG 117 Score = 31.6 bits (70), Expect = 1.8 Identities = 14/20 (70%), Positives = 14/20 (70%) Query: 19 GGGGGGCPGGGGGGGGAGPG 38 G GGGG GGG GGGG G G Sbjct: 93 GYGGGGFGGGGFGGGGFGGG 112 Score = 31.2 bits (69), Expect = 2.4 Identities = 17/38 (44%), Positives = 20/38 (52%), Gaps = 5/38 (13%) Query: 6 LFGEMALAFGCPPGGG-----GGGCPGGGGGGGGAGPG 38 L G +++ GGG GGG GGG GGGG G G Sbjct: 70 LGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGG 107 Score = 30.8 bits (68), Expect = 3.1 Identities = 13/22 (59%), Positives = 13/22 (59%) Query: 15 GCPPGGGGGGCPGGGGGGGGAG 36 G G GGG GGGGGGG G Sbjct: 529 GSSYGSGGGSYGSGGGGGGGRG 550 Score = 30.0 bits (66), Expect = 5.3 Identities = 12/17 (70%), Positives = 12/17 (70%) Query: 20 GGGGGCPGGGGGGGGAG 36 G GGG G GGGGGG G Sbjct: 560 GSGGGSYGSGGGGGGHG 576 Score = 29.6 bits (65), Expect = 6.9 Identities = 16/42 (38%), Positives = 19/42 (45%), Gaps = 10/42 (23%) Query: 7 FGEMALAFGCPPGGGG----------GGCPGGGGGGGGAGPG 38 +G ++G GGGG GG GG GGGGG G Sbjct: 559 YGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSG 600 Score = 29.3 bits (64), Expect = 9.0 Identities = 13/22 (59%), Positives = 13/22 (59%) Query: 19 GGGGGGCPGGGGGGGGAGPGPS 40 GGG G GGGGG G G G S Sbjct: 562 GGGSYGSGGGGGGHGSYGSGSS 583 >gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] Length = 543 Score = 70.5 bits (171), Expect = 4e-12 Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 41/305 (13%) Query: 199 TPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKI 258 T E +AL ++ + R+EEE+ R + + + ++ A EA + E+ ++I Sbjct: 154 TNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRI 213 Query: 259 ERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSK 318 + L E+ K + + + +L +IQ + V+MD+ + D++A L D+ Q Sbjct: 214 DSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKP-DLSAALKDIRAQYE------ 266 Query: 319 IFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDC 378 K+A+ + N + K F L E+ + D Sbjct: 267 -----------KLAAKN------------------MQNAEEWFKSRFTVLTESAAKNTDA 297 Query: 379 DSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQI 438 +E ++ L + T I+ E L + E E Q+TI ++ Sbjct: 298 VRAAKDEVSESRRLLKAKTL---EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKL 354 Query: 439 ELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSDSGS 498 E EL T KS+M R+L EY ++ ++K LD+++ R+L++G R S +SV S SG Sbjct: 355 ENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETR--LSFTSVGSITSGY 412 Query: 499 TDEIQ 503 + Q Sbjct: 413 SQSSQ 417 Score = 41.6 bits (96), Expect = 0.002 Identities = 79/339 (23%), Positives = 143/339 (42%), Gaps = 64/339 (18%) Query: 57 LKGLNVRFRCFLAKVHELERRNRLLEKQ---LEQQQSE------------RERRLRYKTF 101 L+ LN RF F+ +VHELE++N++LE + L Q+ SE R+ RL + Sbjct: 94 LQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDA 153 Query: 102 SRE-QAVQTGPELLRPP-------------APGGGHGLSSGAAAGANANAVALGGLPPGG 147 + E QA+Q E L + G A GA+ A+A L Sbjct: 154 TNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEK-- 211 Query: 148 GSHPQHYGRLPGTIWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEI-RALY 206 R+ + + +++ + +Q + + + V++D P++ AL Sbjct: 212 --------RIDSLMDEISFLKKVHEEEIAELQ----AQIQYAQISVEMDVTKPDLSAALK 259 Query: 207 NVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAI---QEEMNEKIERLKA 263 ++ A+ ++ + + EE R + T + AA+ DA+ ++E++E LKA Sbjct: 260 DIRAQYEKLAAKNMQNAEEWFKSRFTVLT-----ESAAKNTDAVRAAKDEVSESRRLLKA 314 Query: 264 ---ELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIF 320 E+ +G+ L+ ++QE K + DI D KL + + SE +++ Sbjct: 315 KTLEIEACRGMNE----ALEKQLQELEDKQNADISAMQDTINKLENELRTTKSE-MARYL 369 Query: 321 QVVPKKKERKVASDDDISEQ----DGEVNRFSDDEVGSM 355 + K+A D +I+ +GE R S VGS+ Sbjct: 370 KEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSI 408 >gi|109255249 keratin 4 [Homo sapiens] Length = 594 Score = 70.1 bits (170), Expect = 5e-12 Identities = 66/308 (21%), Positives = 132/308 (42%), Gaps = 40/308 (12%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q+DT+ + L + L ++ +++K ++EEE+ KR + L++ A + E Sbjct: 272 QLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVE 331 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K++ L E+ K L ++ + T + + ++ + MD R +D+ + + +V Q Sbjct: 332 LEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQ--Y 389 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 E++++ K E + + + V++ D+ + + E+ RM +LR Sbjct: 390 EEIAQ-----RSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLR---- 440 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 I+ +Q + L + + E + K+ Sbjct: 441 ---------------------------AEIENIKKQCQTLQVSVADAEQRGENALKDAHS 473 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVAS 493 ++E L AK ++ R L EY E+ S+K LD+++ T R+L++G R S S S Sbjct: 474 KRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVS 533 Query: 494 SD--SGST 499 SGST Sbjct: 534 ISVVSGST 541 Score = 36.2 bits (82), Expect = 0.074 Identities = 35/105 (33%), Positives = 49/105 (46%), Gaps = 31/105 (29%) Query: 16 CPPGGGGGGCPGGGGGGGGA-----GPGPSPVTAA-------LRDDLGSNIHL------- 56 C G GG G G GGG GG+ GPG PV A + L + +H+ Sbjct: 147 CFGGAGGFGTGGFGGGFGGSFSGKGGPG-FPVCPAGGIQEVTINQSLLTPLHVEIDPEIQ 205 Query: 57 ---------LKGLNVRFRCFLAKVHELERRNRLLEKQ--LEQQQS 90 +K LN +F F+ KV LE++N++LE + L QQQ+ Sbjct: 206 KVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQT 250 >gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sapiens] Length = 431 Score = 69.3 bits (168), Expect = 8e-12 Identities = 65/286 (22%), Positives = 130/286 (45%), Gaps = 56/286 (19%) Query: 210 AKVKRERDEY-------KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLK 262 A+++ ERD +++ ++E R+ + + ++ A EA + ++ KIE L+ Sbjct: 135 ARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLE 194 Query: 263 AELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQV 322 E+ + + + + +L ++ + + V++D+ + D+TA L ++ Q + Sbjct: 195 EEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYEA--------- 244 Query: 323 VPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLR----ETFDFDDDC 378 +AS + ++ ++F+D +TD R LR E D+ Sbjct: 245 --------MASSNMHEAEEWYRSKFAD-------LTDAAARNAELLRQAKHEANDYRRQL 289 Query: 379 DSLTWEENEDTLLLWEDFTNCNPTIDLQ-GEQEENLGNLIHETESFFKTRDKEYQETIGQ 437 SLT + E N +++ Q EQEE H E+ YQE + + Sbjct: 290 QSLTCD--------LESLRGTNESLERQMREQEER-----HVREA------ASYQEALAR 330 Query: 438 IELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR 483 +E E + K +M RHL EY ++ ++K LD+++ T R+L++G +R Sbjct: 331 LEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 376 >gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] Length = 432 Score = 69.3 bits (168), Expect = 8e-12 Identities = 65/286 (22%), Positives = 130/286 (45%), Gaps = 56/286 (19%) Query: 210 AKVKRERDEY-------KRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLK 262 A+++ ERD +++ ++E R+ + + ++ A EA + ++ KIE L+ Sbjct: 135 ARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLERKIESLE 194 Query: 263 AELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQV 322 E+ + + + + +L ++ + + V++D+ + D+TA L ++ Q + Sbjct: 195 EEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKP-DLTAALKEIRTQYEA--------- 244 Query: 323 VPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLR----ETFDFDDDC 378 +AS + ++ ++F+D +TD R LR E D+ Sbjct: 245 --------MASSNMHEAEEWYRSKFAD-------LTDAAARNAELLRQAKHEANDYRRQL 289 Query: 379 DSLTWEENEDTLLLWEDFTNCNPTIDLQ-GEQEENLGNLIHETESFFKTRDKEYQETIGQ 437 SLT + E N +++ Q EQEE H E+ YQE + + Sbjct: 290 QSLTCD--------LESLRGTNESLERQMREQEER-----HVREA------ASYQEALAR 330 Query: 438 IELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR 483 +E E + K +M RHL EY ++ ++K LD+++ T R+L++G +R Sbjct: 331 LEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR 376 >gi|15431310 keratin 14 [Homo sapiens] Length = 472 Score = 68.9 bits (167), Expect = 1e-11 Identities = 67/301 (22%), Positives = 128/301 (42%), Gaps = 58/301 (19%) Query: 207 NVLAKVKRER---DEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKA 263 NVL ++ R D+++ ++E EL RM+++ ++ L+ E + ++ +IE LK Sbjct: 185 NVLLQIDNARLAADDFRTKYETELNLRMSVEADINGLRRVLDELTLARADLEMQIESLKE 244 Query: 264 ELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQ------RNSEDVS 317 EL K + M L ++ + V+MD +D++ L ++ Q +N +D Sbjct: 245 ELAYLKKNHEEEMNALRGQVGGD-VNVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKDAE 303 Query: 318 KIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDD 377 + F ++ R+VA++ ++ + K ++LR T Sbjct: 304 EWFFTKTEELNREVATNSELVQSG--------------------KSEISELRRTMQ---- 339 Query: 378 CDSLTWEENEDTLLLWEDFTNCNPTIDLQGE--QEENLGNLIHETESFFKTRDKEYQETI 435 N I+LQ + + +L N + ET+ + + + QE I Sbjct: 340 ----------------------NLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMI 377 Query: 436 GQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVASSD 495 G +E +LA + +M + EY + +K L+ ++ T RRL++G S S S S Sbjct: 378 GSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHLSSSQFSSGSQS 437 Query: 496 S 496 S Sbjct: 438 S 438 Score = 40.0 bits (92), Expect = 0.005 Identities = 33/99 (33%), Positives = 46/99 (46%), Gaps = 11/99 (11%) Query: 7 FGEMALAFGCPPGGGGGGCPG---GGGGGGGAGPGPSPVTAALRDDLGSNIHLLKGLNVR 63 F + +FG GGG GG G GGG GGG G + +GS ++ LN R Sbjct: 73 FSSSSSSFGSGFGGGYGGGLGAGLGGGFGGGFAGGDGLL-------VGSEKVTMQNLNDR 125 Query: 64 FRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFS 102 +L KV LE N LE ++ + +R+R K +S Sbjct: 126 LASYLDKVRALEEANADLEVKI-RDWYQRQRPAEIKDYS 163 >gi|67782365 keratin 7 [Homo sapiens] Length = 469 Score = 68.6 bits (166), Expect = 1e-11 Identities = 62/293 (21%), Positives = 121/293 (41%), Gaps = 47/293 (16%) Query: 193 VQID--TITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAI 250 +Q+D + E+R++ +V+ +++K ++E+E+ R + L++ A Sbjct: 155 LQVDGGRLEAELRSMQDVV-------EDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMS 207 Query: 251 QEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQ 310 + E+ K++ L E+ + L +T+L ++I + ++ + MD R +D+ + +V Q Sbjct: 208 KVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQ 267 Query: 311 RNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRE 370 E+++K + E + + + DD + N EM R +L+ Sbjct: 268 --YEEMAKC-----SRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQ- 319 Query: 371 TFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKE 430 ID Q L I E E + K+ Sbjct: 320 ------------------------------AEIDNIKNQRAKLEAAIAEAEERGELALKD 349 Query: 431 YQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR 483 + ++E L K DM R L EY E+ S+K LD+++ T R+L++G R Sbjct: 350 ARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESR 402 Score = 44.3 bits (103), Expect = 3e-04 Identities = 48/179 (26%), Positives = 83/179 (46%), Gaps = 32/179 (17%) Query: 193 VQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQ-EAAQEADAIQ 251 + +D I E++A Y +AK R E W QT +TLQ +A + D ++ Sbjct: 255 LDLDGIIAEVKAQYEEMAKCSRAEAE---AW---------YQTKFETLQAQAGKHGDDLR 302 Query: 252 E------EMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKL- 304 EMN I+RL+AE+ K + L+ I E + ++ + D AK Sbjct: 303 NTRNEISEMNRAIQRLQAEIDNIK----NQRAKLEAAIAEAEERGELALK---DARAKQE 355 Query: 305 -CDVAQQRNSEDVSKIFQVVPKKKERKVASDDDISEQ----DGEVNRFSDDEVGSMNIT 358 + A QR +D+++ + + K+A D +I+ +GE +R + D VG++NI+ Sbjct: 356 ELEAALQRGKQDMARQLREYQELMSVKLALDIEIATYRKLLEGEESRLAGDGVGAVNIS 414 >gi|14249342 internexin neuronal intermediate filament protein, alpha [Homo sapiens] Length = 499 Score = 68.2 bits (165), Expect = 2e-11 Identities = 68/283 (24%), Positives = 124/283 (43%), Gaps = 46/283 (16%) Query: 215 ERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSD 274 E + R EEE R + + Q A + ++ +K+E L EL + + + Sbjct: 174 EVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDE 233 Query: 275 PMTDLDTKIQ---EKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKV 331 + +L +Q + A +VD+ + + D+T+ L ++ Q S +K Q + + K Sbjct: 234 EVAELLATLQASSQAAAEVDVTVAKP-DLTSALREIRAQYESL-AAKNLQSAEEWYKSKF 291 Query: 332 ASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLL 391 A+ ++ + + E R S +E+ E +R Q R Sbjct: 292 ANLNEQAARSTEAIRASREEI------HEYRRQL-QAR---------------------- 322 Query: 392 LWEDFTNCNPTIDLQGEQ--EENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDM 449 TI+++G + E+L I E E YQ++IGQ+E +L KS+M Sbjct: 323 ----------TIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEM 372 Query: 450 NRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADRNSPSPSSVA 492 RHL EY ++ ++K LD+++ R+L++G R S S S++ Sbjct: 373 ARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSIS 415 Score = 38.1 bits (87), Expect = 0.019 Identities = 20/41 (48%), Positives = 27/41 (65%), Gaps = 3/41 (7%) Query: 57 LKGLNVRFRCFLAKVHELERRNRLLEKQ---LEQQQSERER 94 L+GLN RF F+ KVH+LE +NR LE + L Q+ +E R Sbjct: 98 LQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSR 138 >gi|153791670 keratin 76 [Homo sapiens] Length = 638 Score = 67.0 bits (162), Expect = 4e-11 Identities = 69/328 (21%), Positives = 136/328 (41%), Gaps = 45/328 (13%) Query: 160 TIWSYTQVRRTGGG--GVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERD 217 T W Q + TG G +E +S++ Q+D++ E L L ++ + Sbjct: 213 TKWELLQQQTTGSGPSSLEPCFESYISFLCK-----QLDSLLGERGNLEGELKSMQDLVE 267 Query: 218 EYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDPMT 277 ++K+++E+E+ KR + L++ A + E+ K++ L E+ + L ++ Sbjct: 268 DFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELS 327 Query: 278 DLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDDDI 337 + + + ++ + MD R +D+ + + +V Q E++++ K E + + Sbjct: 328 QMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQ--YEEIAQ-----RSKSEAEALYQTKL 380 Query: 338 SEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWEDFT 397 E R DD + + E+ RM +LR Sbjct: 381 GELQTTAGRHGDDLRNTKSEIMELNRMIQRLR---------------------------- 412 Query: 398 NCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKSDMNRHLHEYM 457 I+ +Q NL I E E + K+ + ++ L AK D+ R L +Y Sbjct: 413 ---AEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQ 469 Query: 458 EMCSMKRGLDVQMETCRRLIKGSADRNS 485 E+ ++K LDV++ T R+L++G R S Sbjct: 470 ELMNVKLALDVEIATYRKLLEGEECRMS 497 Score = 41.6 bits (96), Expect = 0.002 Identities = 39/125 (31%), Positives = 50/125 (40%), Gaps = 36/125 (28%) Query: 14 FGCPPGGGGGGC---PGGGGGGGGAGPGPSP-------VTAALRDDLGSNI--------- 54 FG G GG G PG GG GG GPG P V +L L I Sbjct: 122 FGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVKA 181 Query: 55 ---HLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLRYKTFSREQAVQTGP 111 +K LN +F F+ KV LE++N++LE + E Q +Q +GP Sbjct: 182 QEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQ--------------QQTTGSGP 227 Query: 112 ELLRP 116 L P Sbjct: 228 SSLEP 232 >gi|27477127 keratin 82 [Homo sapiens] Length = 513 Score = 67.0 bits (162), Expect = 4e-11 Identities = 72/335 (21%), Positives = 132/335 (39%), Gaps = 57/335 (17%) Query: 156 RLPGTIWSYTQVRRTGGGGVETVQGPGVSWVHPDGVGVQIDTITPEIRALYNVLAKVKRE 215 +L T W++ Q +R +E + +S + Q+D ++ + L + L ++ Sbjct: 146 KLLETKWNFMQQQRCCQTNIEPIFEGYISALRR-----QLDCVSGDRVRLESELCSLQAA 200 Query: 216 RDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVFKGLMSDP 275 + YK+++EEEL+ R ++ L++ A ++ ++ E L E+ K L + Sbjct: 201 LEGYKKKYEEELSLRPCVENEFVALKKDVDTAFLMKADLETNAEALVQEIDFLKSLYEEE 260 Query: 276 MTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKERKVASDD 335 + L ++I E ++ V MD R +D+ + ++ K DD Sbjct: 261 ICLLQSQISETSVIVKMDNSRELDVDGIIAEI----------------------KAQYDD 298 Query: 336 DISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFDFDDDCDSLTWEENEDTLLLWED 395 S E + + +T + CD+L +NE Sbjct: 299 IASRSKAEAEAWYQCRYEELRVT---------------AGNHCDNLRNRKNE-------- 335 Query: 396 FTNCNPTIDLQGEQEEN-------LGNLIHETESFFKTRDKEYQETIGQIELELATAKSD 448 N I ++ EN L I E E + + + + +E L AK D Sbjct: 336 ILEMNKLIQRLQQETENVKAQRCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQD 395 Query: 449 MNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR 483 M L EY E+ + K GLD+++ T RRL++G R Sbjct: 396 MACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHR 430 >gi|47132620 keratin 2 [Homo sapiens] Length = 639 Score = 67.0 bits (162), Expect = 4e-11 Identities = 68/315 (21%), Positives = 133/315 (42%), Gaps = 43/315 (13%) Query: 189 DGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEAD 248 D + +D +T E + + L ++ ++YK+++E+E+ KR + TL++ A Sbjct: 234 DSLKRYLDGLTAERTSQNSELNNMQDLVEDYKKKYEDEINKRTAAENDFVTLKKDVDNAY 293 Query: 249 AIQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVA 308 I+ E+ K++ L E+ K L ++ + + + + + MD R +D+ + + +V Sbjct: 294 MIKVELQSKVDLLNQEIEFLKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIAEVK 353 Query: 309 QQRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQL 368 Q E++++ K+E + E V R D E+ R+ +L Sbjct: 354 AQY--EEIAQ-----RSKEEAEALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRL 406 Query: 369 RETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRD 428 + I +Q +N+ + I + E + Sbjct: 407 QGE-------------------------------IAHVKKQCKNVQDAIADAEQRGEHAL 435 Query: 429 KEYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKG-----SADR 483 K+ + + +E L AK D+ R L +Y E+ ++K LDV++ T R+L++G S D Sbjct: 436 KDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGDL 495 Query: 484 NSPSPSSVASSDSGS 498 +S SV SS S Sbjct: 496 SSNVTVSVTSSTISS 510 Score = 39.3 bits (90), Expect = 0.009 Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 13/89 (14%) Query: 14 FGCPPGGGGGGCPGGGGGGGGAG-------------PGPSPVTAALRDDLGSNIHLLKGL 60 FG P G GG G PGG G GG G P V +++ +K L Sbjct: 126 FGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQEREQIKTL 185 Query: 61 NVRFRCFLAKVHELERRNRLLEKQLEQQQ 89 N +F F+ KV LE++N++L+ + E Q Sbjct: 186 NNKFASFIDKVRFLEQQNQVLQTKWELLQ 214 Score = 35.4 bits (80), Expect = 0.13 Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 2/61 (3%) Query: 120 GGGHGLSSGAAAGANANAVALGGLPPGGGSHPQHYGRLPGTIWSYTQVRRTGGGGVETVQ 179 GGG G G+ G+ +++ GG GGG H G G+ S +GGGG +V+ Sbjct: 566 GGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGSRGGS--SSGGGYGSGGGGSSSVK 623 Query: 180 G 180 G Sbjct: 624 G 624 Score = 31.6 bits (70), Expect = 1.8 Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 6 LFGEMALAFGCPPGGGGGGCPGG-GGGGGGAGPGPS 40 L G +++ GGGG G GG GG GGG G G S Sbjct: 66 LGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSS 101 Score = 30.0 bits (66), Expect = 5.3 Identities = 14/32 (43%), Positives = 15/32 (46%) Query: 7 FGEMALAFGCPPGGGGGGCPGGGGGGGGAGPG 38 +G G G GGGG GGG G G G G Sbjct: 539 YGSGGRQSGSRGGSGGGGSISGGGYGSGGGSG 570 Score = 29.6 bits (65), Expect = 6.9 Identities = 14/36 (38%), Positives = 18/36 (50%) Query: 19 GGGGGGCPGGGGGGGGAGPGPSPVTAALRDDLGSNI 54 GGG G GGG G G G S V + + GS++ Sbjct: 599 GGGSRGGSSSGGGYGSGGGGSSSVKGSSGEAFGSSV 634 >gi|5031839 keratin 6A [Homo sapiens] Length = 564 Score = 67.0 bits (162), Expect = 4e-11 Identities = 65/290 (22%), Positives = 122/290 (42%), Gaps = 38/290 (13%) Query: 194 QIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEE 253 Q+D+I E L + L ++ +++K ++E+E+ KR + TL++ A + E Sbjct: 224 QLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYMNKVE 283 Query: 254 MNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNS 313 + K + L E+ + L ++ + T I + ++ + MD R +D+ + + +V Q Sbjct: 284 LQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKAQY-- 341 Query: 314 EDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLRETFD 373 E++++ + E + E R DD + E+ RM +LR Sbjct: 342 EEIAQ-----RSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSE-- 394 Query: 374 FDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQE 433 ID +Q NL I + E + K+ + Sbjct: 395 -----------------------------IDHVKKQCANLQAAIADAEQRGEMALKDAKN 425 Query: 434 TIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR 483 + +E L AK D+ R L EY E+ ++K LDV++ T R+L++G R Sbjct: 426 KLEGLEDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLLEGEECR 475 Score = 35.4 bits (80), Expect = 0.13 Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 24/115 (20%) Query: 7 FGEMALAFGCPPGGGGGGCPGGGGG--GGGAGPG----------PSPVTAALRDDLGSNI 54 FG FG G G G GGG G GG GPG V +L L I Sbjct: 93 FGGAGSGFGFGGGAGIGFGLGGGAGLAGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQI 152 Query: 55 ------------HLLKGLNVRFRCFLAKVHELERRNRLLEKQLEQQQSERERRLR 97 +K LN +F F+ KV LE++N++LE + Q + + +R Sbjct: 153 DPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVR 207 >gi|28372503 keratin 72 isoform 1 [Homo sapiens] Length = 511 Score = 66.6 bits (161), Expect = 5e-11 Identities = 68/315 (21%), Positives = 137/315 (43%), Gaps = 54/315 (17%) Query: 190 GVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADA 249 G GV++D+ E+R + +++ ++YK+R+E E+ +R + L++ A Sbjct: 192 GDGVRLDS---ELRNMQDLV-------EDYKKRYEVEINRRTAAENEFVVLKKDVDAAYM 241 Query: 250 IQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQ 309 + E+ K++ L E+ FK L +T + + I + ++ + MD R +D+ + + +V Sbjct: 242 NKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDNNRDLDLDSIIAEVRA 301 Query: 310 QRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLR 369 Q E+++ + K E + I E + DD + E+ R+ ++R Sbjct: 302 Q--YEEIA-----LKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEISELNRLIQRIR 354 Query: 370 ETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDK 429 I +Q +L I + E K Sbjct: 355 S-------------------------------EIGNVKKQCADLETAIADAEQRGDCALK 383 Query: 430 EYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR------ 483 + + + ++E L AK ++ R L EY E+ S+K LD+++ T R+L++ R Sbjct: 384 DARAKLDELEGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYP 443 Query: 484 NSPSPSSVASSDSGS 498 NS S S ++S+++G+ Sbjct: 444 NSVSISVISSTNAGA 458 >gi|226246663 keratin 72 isoform 1 [Homo sapiens] Length = 511 Score = 66.6 bits (161), Expect = 5e-11 Identities = 68/315 (21%), Positives = 137/315 (43%), Gaps = 54/315 (17%) Query: 190 GVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADA 249 G GV++D+ E+R + +++ ++YK+R+E E+ +R + L++ A Sbjct: 192 GDGVRLDS---ELRNMQDLV-------EDYKKRYEVEINRRTAAENEFVVLKKDVDAAYM 241 Query: 250 IQEEMNEKIERLKAELVVFKGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQ 309 + E+ K++ L E+ FK L +T + + I + ++ + MD R +D+ + + +V Sbjct: 242 NKVELQAKVDSLTDEIKFFKCLYEGEITQIQSHISDTSIVLSMDNNRDLDLDSIIAEVRA 301 Query: 310 QRNSEDVSKIFQVVPKKKERKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLR 369 Q E+++ + K E + I E + DD + E+ R+ ++R Sbjct: 302 Q--YEEIA-----LKSKAEAETLYQTKIQELQVTAGQHGDDLKLTKAEISELNRLIQRIR 354 Query: 370 ETFDFDDDCDSLTWEENEDTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDK 429 I +Q +L I + E K Sbjct: 355 S-------------------------------EIGNVKKQCADLETAIADAEQRGDCALK 383 Query: 430 EYQETIGQIELELATAKSDMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR------ 483 + + + ++E L AK ++ R L EY E+ S+K LD+++ T R+L++ R Sbjct: 384 DARAKLDELEGALHQAKEELARMLREYQELVSLKLALDMEIATYRKLLESEECRMSGEYP 443 Query: 484 NSPSPSSVASSDSGS 498 NS S S ++S+++G+ Sbjct: 444 NSVSISVISSTNAGA 458 >gi|125628636 keratin 80 isoform a [Homo sapiens] Length = 452 Score = 66.2 bits (160), Expect = 7e-11 Identities = 60/290 (20%), Positives = 127/290 (43%), Gaps = 41/290 (14%) Query: 209 LAKVKRERDEYKRRWEEELAKRMNLQTMVDTLQEAAQEADAIQEEMNEKIERLKAELVVF 268 L +V + +E++ R+E+E++KR +++ L++ + E+ K++ L++ + + Sbjct: 157 LLQVLEKVEEFRIRYEDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELM 216 Query: 269 KGLMSDPMTDLDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNSEDVSKIFQVVPKKKE 328 K + + DL ++++ ++ V MD ID++ + +V Q ++ + +E Sbjct: 217 KTIYEQELKDLAAQVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSL-------EE 269 Query: 329 RKVASDDDISEQDGEVNRFSDDEVGSMNITDEMKRMFNQLR-ETFDFDDDCDSLTWEENE 387 + S + EQ + S + ++ +LR + C L Sbjct: 270 AEAYSRSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKL------ 323 Query: 388 DTLLLWEDFTNCNPTIDLQGEQEENLGNLIHETESFFKTRDKEYQETIGQIELELATAKS 447 EEN+ + E F ++ + + Q+E L AK Sbjct: 324 ----------------------EENIKTAEEQGELAF----QDAKTKLAQLEAALQQAKQ 357 Query: 448 DMNRHLHEYMEMCSMKRGLDVQMETCRRLIKGSADR-NSPSPSSVASSDS 496 DM R L +Y E+ ++K LD+++ T R+L++G R +SPS + V++ S Sbjct: 358 DMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRMDSPSATVVSAVQS 407 Score = 29.6 bits (65), Expect = 6.9 Identities = 13/26 (50%), Positives = 18/26 (69%) Query: 57 LKGLNVRFRCFLAKVHELERRNRLLE 82 +K LN +F + KV LE+RN+LLE Sbjct: 87 MKALNDKFASLIGKVQALEQRNQLLE 112 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.133 0.389 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,257,193 Number of Sequences: 37866 Number of extensions: 1235531 Number of successful extensions: 20592 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 434 Number of HSP's successfully gapped in prelim test: 366 Number of HSP's that attempted gapping in prelim test: 11633 Number of HSP's gapped (non-prelim): 6013 length of query: 517 length of database: 18,247,518 effective HSP length: 107 effective length of query: 410 effective length of database: 14,195,856 effective search space: 5820300960 effective search space used: 5820300960 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.