BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] (669 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 1347 0.0 gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 1296 0.0 gi|13128864 histone deacetylase 6 [Homo sapiens] 407 e-113 gi|153085395 histone deacetylase 4 [Homo sapiens] 238 2e-62 gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 236 7e-62 gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 236 7e-62 gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 235 9e-62 gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 235 9e-62 gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 232 7e-61 gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 232 7e-61 gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 226 5e-59 gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 140 5e-33 gi|13128860 histone deacetylase 1 [Homo sapiens] 96 1e-19 gi|116284376 histone deacetylase 2 [Homo sapiens] 95 2e-19 gi|8923769 histone deacetylase 8 [Homo sapiens] 92 2e-18 gi|13128862 histone deacetylase 3 [Homo sapiens] 77 7e-14 gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 68 2e-11 gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 61 3e-09 gi|222418647 mucin 7, secreted precursor [Homo sapiens] 47 7e-05 gi|222418649 mucin 7, secreted precursor [Homo sapiens] 47 7e-05 gi|222418645 mucin 7, secreted precursor [Homo sapiens] 47 7e-05 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 41 0.004 gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens] 40 0.005 gi|239754940 PREDICTED: hypothetical protein [Homo sapiens] 40 0.007 gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 39 0.016 gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 39 0.016 gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho... 39 0.016 gi|150170670 piccolo isoform 2 [Homo sapiens] 39 0.020 gi|150378539 piccolo isoform 1 [Homo sapiens] 39 0.020 gi|116284392 mucin 2 precursor [Homo sapiens] 37 0.077 >gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] Length = 669 Score = 1347 bits (3487), Expect = 0.0 Identities = 669/669 (100%), Positives = 669/669 (100%) Query: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL Sbjct: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60 Query: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG Sbjct: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120 Query: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ Sbjct: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180 Query: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA Sbjct: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240 Query: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV Sbjct: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300 Query: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ Sbjct: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360 Query: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD Sbjct: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420 Query: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA Sbjct: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480 Query: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS Sbjct: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540 Query: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL Sbjct: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600 Query: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM Sbjct: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660 Query: 661 LQCHPHLVA 669 LQCHPHLVA Sbjct: 661 LQCHPHLVA 669 >gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] Length = 649 Score = 1296 bits (3354), Expect = 0.0 Identities = 649/669 (97%), Positives = 649/669 (97%), Gaps = 20/669 (2%) Query: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL Sbjct: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60 Query: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG Sbjct: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120 Query: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ Sbjct: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180 Query: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA Sbjct: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240 Query: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300 AFLHLLLPLAFE GQMQATPECFAHLTQLLQVLAGGRVCAV Sbjct: 241 AFLHLLLPLAFE--------------------GQMQATPECFAHLTQLLQVLAGGRVCAV 280 Query: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ Sbjct: 281 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 340 Query: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD Sbjct: 341 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 400 Query: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA Sbjct: 401 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 460 Query: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS Sbjct: 461 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 520 Query: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL Sbjct: 521 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 580 Query: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM Sbjct: 581 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 640 Query: 661 LQCHPHLVA 669 LQCHPHLVA Sbjct: 641 LQCHPHLVA 649 >gi|13128864 histone deacetylase 6 [Homo sapiens] Length = 1215 Score = 407 bits (1046), Expect = e-113 Identities = 203/388 (52%), Positives = 267/388 (68%), Gaps = 8/388 (2%) Query: 2 GTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELG 61 GT LV E + LWDD E PERL A ++L Q GL RC+ AR A +EEL Sbjct: 85 GTGLVLDEQLNEFHCLWDDSFPE--GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELM 142 Query: 62 LVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGA 121 LVHS EY+ L+ TQ + + EL+ L+ +D++Y HP+++ CA LA+G+ L+LVDAVL Sbjct: 143 LVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAE 202 Query: 122 VQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQY 181 ++NG+A++RPPGHH Q + +G+C+FN+VA+AA +A+QKH + R+L+VDWDVHHGQG Q+ Sbjct: 203 IRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQF 262 Query: 182 LFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAA 241 F+ DPSVLYFS HRYE GRFWP L+ S+ G GQG G+T+N+PWNQVGM +ADY+AA Sbjct: 263 TFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAA 322 Query: 242 FLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVL 301 FLH+LLP+A EF P+LVLV+AGFD+ GDP+G+M ATP FA LT LL LAGG++ L Sbjct: 323 FLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSL 382 Query: 302 EGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQD 361 EGGY+L +LAE V ++ TLLGDP P L P APC+SA S+ A A P W+ L + Sbjct: 383 EGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRST 442 Query: 362 VTA----VPMSPSSHSPEGRP--PPLLP 383 T + S E P PP+LP Sbjct: 443 ETVERDNMEEDNVEESEEEGPWEPPVLP 470 Score = 361 bits (926), Expect = 1e-99 Identities = 188/361 (52%), Positives = 241/361 (66%), Gaps = 3/361 (0%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T LVY ++M LWD E+ P+R+ + RL + GL RCL L+ R A+E EL Sbjct: 481 TGLVYDQNMMNHCNLWDSHHPEV--PQRILRIMCRLEELGLAGRCLTLTPRPATEAELLT 538 Query: 63 VHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAV 122 HS EYV +R T+ + EL S FD+IY PSTF CA+LA GA +LV+AVL+G V Sbjct: 539 CHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEV 598 Query: 123 QNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHG-LHRILVVDWDVHHGQGIQY 181 NG A+VRPPGHH ++ AA GFC FN+VA+AA HA+ G RIL+VDWDVHHG G Q+ Sbjct: 599 LNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQH 658 Query: 182 LFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAA 241 +FEDDPSVLY S HRY+HG F+P E + +GR G GFTVN+ WN MG+ADY+AA Sbjct: 659 MFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAA 718 Query: 242 FLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVL 301 + L+LP+A+EF+PELVLVSAGFD+A GDP G Q +PE +AHLT LL LA GR+ +L Sbjct: 719 WHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILIL 778 Query: 302 EGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQD 361 EGGY+L S++ES+ ++LLGDP P L+ P P AL SI +W+SL+ Sbjct: 779 EGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMK 838 Query: 362 V 362 V Sbjct: 839 V 839 Score = 43.1 bits (100), Expect = 8e-04 Identities = 34/85 (40%), Positives = 43/85 (50%), Gaps = 13/85 (15%) Query: 562 LVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRGLAGGRVLALLEE- 611 LVLP+AY F P+LVLV+ G P G Q P A L +L GLA GR++ +LE Sbjct: 722 LVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGG 781 Query: 612 ---NSTPQLAGILARVLNGEAPPSL 633 S + R L G+ PP L Sbjct: 782 YNLTSISESMAACTRSLLGDPPPLL 806 Score = 41.2 bits (95), Expect = 0.003 Identities = 38/121 (31%), Positives = 55/121 (45%), Gaps = 15/121 (12%) Query: 555 FLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAA----------MLRGLAGGR 604 +++ L ++LP+A FQP LVLVA G LQG +AA +L GLAGG+ Sbjct: 319 YIAAFLHVLLPVALEFQPQLVLVAAG-FDALQGDPKGEMAATPAGFAQLTHLLMGLAGGK 377 Query: 605 VLALLE--ENSTPQLAGILA--RVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660 ++ LE N G+ A L G+ P L ++ LEP W++ Sbjct: 378 LILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEV 437 Query: 661 L 661 L Sbjct: 438 L 438 >gi|153085395 histone deacetylase 4 [Homo sapiens] Length = 1084 Score = 238 bits (606), Expect = 2e-62 Identities = 144/387 (37%), Positives = 209/387 (54%), Gaps = 27/387 (6%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T LVY M + E R+ + RL++ GL +C + R+A+ EEL Sbjct: 654 TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQT 713 Query: 63 VHSPEYVSL-----VRETQVLGKEELQALSGQF------------DAIYFHPSTFHCARL 105 VHS + L + ++ K+ L +L+ F D I+ + ARL Sbjct: 714 VHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARL 773 Query: 106 AAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHR 165 A G ++LV V TG ++NG A+VRPPGHH + + GFC FN+VA+AA +Q+ + + Sbjct: 774 AVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSK 833 Query: 166 ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVN 225 IL+VDWDVHHG G Q F DPSVLY S HRY+ G F+P D VG G G+GF VN Sbjct: 834 ILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVN 891 Query: 226 LPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATPE 280 + + MG+A+Y+AAF +++P+A EF P++VLVS+GFD+ G P G + Sbjct: 892 MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951 Query: 281 CFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLG---DPAPPLSGPMAPCQ 337 CF +LT+ L LAGGR+ LEGG+ L ++ ++ V LLG DP P P Sbjct: 952 CFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA 1011 Query: 338 SALESIQSARAAQAPHWKSLQQQDVTA 364 +A+ S++ + +W+ LQ+ TA Sbjct: 1012 NAVRSMEKVMEIHSKYWRCLQRTTSTA 1038 Score = 37.7 bits (86), Expect = 0.035 Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 11/73 (15%) Query: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597 P+ +L+ +V+P+A F PD+VLV+ G G+ L L L Sbjct: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960 Query: 598 RGLAGGRVLALLE 610 GLAGGR++ LE Sbjct: 961 MGLAGGRIVLALE 973 >gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] Length = 1069 Score = 236 bits (601), Expect = 7e-62 Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 636 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695 Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 696 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754 Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 755 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814 Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 815 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872 Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 +N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T Sbjct: 873 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932 Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 933 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992 Query: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366 +A+ S+Q Q+ +WKS++ + AVP Sbjct: 993 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020 >gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] Length = 1066 Score = 236 bits (601), Expect = 7e-62 Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692 Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751 Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811 Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869 Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 +N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T Sbjct: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929 Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989 Query: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366 +A+ S+Q Q+ +WKS++ + AVP Sbjct: 990 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017 >gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] Length = 1123 Score = 235 bits (600), Expect = 9e-62 Identities = 134/384 (34%), Positives = 207/384 (53%), Gaps = 30/384 (7%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T +VY M + + + E R+ + RL++ GL +C R+ R+A+ +E+ Sbjct: 684 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 743 Query: 63 VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103 VHS EY +L+ T L +++L + + D ++ + Sbjct: 744 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 802 Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 R+A G L+L V G ++NG A++RPPGHH + + A GFC FN+VAI A +QK + Sbjct: 803 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 862 Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 ++L+VDWD+HHG G Q F +DPSVLY S HRY++G F+P + VG G G+G+ Sbjct: 863 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 920 Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 VN+ W +G+ +Y+ AF +++P+A EF P++VLVSAGFD+ G P G T Sbjct: 921 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 980 Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 CF HLT+ L LAGGRV LEGG+ L ++ ++ V LL PL + P Sbjct: 981 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1040 Query: 336 CQSALESIQSARAAQAPHWKSLQQ 359 +A+ +++ Q+ HW +Q+ Sbjct: 1041 NINAVATLEKVIEIQSKHWSCVQK 1064 Score = 34.7 bits (78), Expect = 0.29 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%) Query: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597 P+ +L+ +V+P+A+ F PD+VLV+ G G+ + L L Sbjct: 932 PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 991 Query: 598 RGLAGGRVLALLE 610 LAGGRV+ LE Sbjct: 992 MTLAGGRVVLALE 1004 >gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] Length = 1122 Score = 235 bits (600), Expect = 9e-62 Identities = 134/384 (34%), Positives = 207/384 (53%), Gaps = 30/384 (7%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T +VY M + + + E R+ + RL++ GL +C R+ R+A+ +E+ Sbjct: 683 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 742 Query: 63 VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103 VHS EY +L+ T L +++L + + D ++ + Sbjct: 743 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 801 Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 R+A G L+L V G ++NG A++RPPGHH + + A GFC FN+VAI A +QK + Sbjct: 802 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 861 Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 ++L+VDWD+HHG G Q F +DPSVLY S HRY++G F+P + VG G G+G+ Sbjct: 862 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 919 Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 VN+ W +G+ +Y+ AF +++P+A EF P++VLVSAGFD+ G P G T Sbjct: 920 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 979 Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 CF HLT+ L LAGGRV LEGG+ L ++ ++ V LL PL + P Sbjct: 980 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1039 Query: 336 CQSALESIQSARAAQAPHWKSLQQ 359 +A+ +++ Q+ HW +Q+ Sbjct: 1040 NINAVATLEKVIEIQSKHWSCVQK 1063 Score = 34.7 bits (78), Expect = 0.29 Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%) Query: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597 P+ +L+ +V+P+A+ F PD+VLV+ G G+ + L L Sbjct: 931 PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 990 Query: 598 RGLAGGRVLALLE 610 LAGGRV+ LE Sbjct: 991 MTLAGGRVVLALE 1003 >gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] Length = 954 Score = 232 bits (592), Expect = 7e-61 Identities = 145/383 (37%), Positives = 202/383 (52%), Gaps = 28/383 (7%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T L+Y M + D E R+ + RL++RGL +C L R+AS EEL Sbjct: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581 Query: 63 VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104 VHS +V L + L +L L Q D I+ + + AR Sbjct: 582 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 641 Query: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164 AAG+ L V + ++NG A+VRPPGHH + A GFC FN+VAIA +Q+ Sbjct: 642 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 701 Query: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224 +IL+VDWDVHHG G Q F DPSVLY S HR++ G F+P D VG G G GF V Sbjct: 702 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 759 Query: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATP 279 N+ W MG+ +Y+AAF +++P+A EF P+LVLVSAGFD+A G P G + Sbjct: 760 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 819 Query: 280 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 336 +CF ++TQ L LAGG V LEGG+ L ++ ++ V LLG+ PLS P Sbjct: 820 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 879 Query: 337 QSALESIQSARAAQAPHWKSLQQ 359 +A+ S+++ + +W +Q+ Sbjct: 880 LNAIRSLEAVIRVHSKYWGCMQR 902 Score = 33.1 bits (74), Expect = 0.85 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%) Query: 555 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 603 +L+ +V+P+A F PDLVLV+ G GH L G H + + L LAGG Sbjct: 776 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 835 Query: 604 RVLALLE 610 V+ LE Sbjct: 836 AVVLALE 842 >gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] Length = 991 Score = 232 bits (592), Expect = 7e-61 Identities = 145/383 (37%), Positives = 202/383 (52%), Gaps = 28/383 (7%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T L+Y M + D E R+ + RL++RGL +C L R+AS EEL Sbjct: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618 Query: 63 VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104 VHS +V L + L +L L Q D I+ + + AR Sbjct: 619 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 678 Query: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164 AAG+ L V + ++NG A+VRPPGHH + A GFC FN+VAIA +Q+ Sbjct: 679 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 738 Query: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224 +IL+VDWDVHHG G Q F DPSVLY S HR++ G F+P D VG G G GF V Sbjct: 739 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 796 Query: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATP 279 N+ W MG+ +Y+AAF +++P+A EF P+LVLVSAGFD+A G P G + Sbjct: 797 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 856 Query: 280 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 336 +CF ++TQ L LAGG V LEGG+ L ++ ++ V LLG+ PLS P Sbjct: 857 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 916 Query: 337 QSALESIQSARAAQAPHWKSLQQ 359 +A+ S+++ + +W +Q+ Sbjct: 917 LNAIRSLEAVIRVHSKYWGCMQR 939 Score = 33.1 bits (74), Expect = 0.85 Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%) Query: 555 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 603 +L+ +V+P+A F PDLVLV+ G GH L G H + + L LAGG Sbjct: 813 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 872 Query: 604 RVLALLE 610 V+ LE Sbjct: 873 AVVLALE 879 >gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] Length = 1011 Score = 226 bits (576), Expect = 5e-59 Identities = 136/369 (36%), Positives = 201/369 (54%), Gaps = 30/369 (8%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692 Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751 Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811 Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+ Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869 Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278 +N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T Sbjct: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929 Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335 +CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P Sbjct: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989 Query: 336 CQSALESIQ 344 +A+ S+Q Sbjct: 990 NMNAVISLQ 998 >gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] Length = 879 Score = 140 bits (352), Expect = 5e-33 Identities = 80/221 (36%), Positives = 117/221 (52%), Gaps = 20/221 (9%) Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62 T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692 Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103 VHS E+ SL+ T L ++L L D I+ + A Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751 Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163 R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + + Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811 Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWP 204 +IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852 >gi|13128860 histone deacetylase 1 [Homo sapiens] Length = 482 Score = 95.5 bits (236), Expect = 1e-19 Identities = 80/304 (26%), Positives = 134/304 (44%), Gaps = 28/304 (9%) Query: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86 +P R+ + L GL ++ +A+ EE+ HS +Y+ +R + E Sbjct: 31 KPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ 90 Query: 87 SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142 +F+ P F +L+ G + AV Q +A+ G HH +++ A+ Sbjct: 91 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEAS 148 Query: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202 GFC N++ +A + H R+L +D D+HHG G++ F V+ S+H+Y G + Sbjct: 149 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 204 Query: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSA 262 +P D +G G+G + VN P G+ + Y A F ++ + F P V++ Sbjct: 205 FP--GTGDLRDIGAGKGKYYAVNYPLRD-GIDDESYEAIFKPVMSKVMEMFQPSAVVLQC 261 Query: 263 GFDSAIGDPEGQMQAT----PEC--FAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCM 316 G DS GD G T +C F L ++ GG GGY + ++A C Sbjct: 262 GSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG-------GGYTIRNVAR--CW 312 Query: 317 TVQT 320 T +T Sbjct: 313 TYET 316 >gi|116284376 histone deacetylase 2 [Homo sapiens] Length = 582 Score = 94.7 bits (234), Expect = 2e-19 Identities = 77/304 (25%), Positives = 135/304 (44%), Gaps = 28/304 (9%) Query: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86 +P R+ + L GL ++ +A+ EE+ HS EY+ +R + E Sbjct: 126 KPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQ 185 Query: 87 SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142 +F+ P F +L+ G + AV Q +A+ G HH +++ A+ Sbjct: 186 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEAS 243 Query: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202 GFC N++ +A + H R+L +D D+HHG G++ F V+ S+H+Y G + Sbjct: 244 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 299 Query: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSA 262 +P D +G G+G + VN P G+ + Y F ++ + + P V++ Sbjct: 300 FP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIFKPIISKVMEMYQPSAVVLQC 356 Query: 263 GFDSAIGDPEGQMQATPECFAHLTQLLQ------VLAGGRVCAVLEGGYHLESLAESVCM 316 G DS GD G T + A ++++ ++ GG GGY + ++A C Sbjct: 357 GADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG-------GGYTIRNVAR--CW 407 Query: 317 TVQT 320 T +T Sbjct: 408 TYET 411 >gi|8923769 histone deacetylase 8 [Homo sapiens] Length = 377 Score = 91.7 bits (226), Expect = 2e-18 Identities = 80/306 (26%), Positives = 139/306 (45%), Gaps = 26/306 (8%) Query: 28 PERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALS 87 P+R + + L ++ + + AS EE+ H+ Y+ +++ G ++ S Sbjct: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDD-HPDS 93 Query: 88 GQFDAIYFHPST---FHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANG 143 ++ Y P+T F A GA + ++ G + +A+ G HH ++ A+G Sbjct: 94 IEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK--VAINWSGGWHHAKKDEASG 151 Query: 144 FCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFW 203 FC N+ + ++K RIL VD D+HHG G++ F V+ S H++ G F+ Sbjct: 152 FCYLNDAVLGILRLRRK--FERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FF 208 Query: 204 PFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAG 263 P D VG G+G ++VN+P Q G+ + Y +L + F+P+ V++ G Sbjct: 209 P--GTGDVSDVGLGKGRYYSVNVP-IQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLG 265 Query: 264 FDSAIGDPEGQMQATP----ECFAHLT--QLLQVLAGGRVCAVLEGGYHLESLAESVCMT 317 D+ GDP TP +C ++ QL ++ GG GGY+L + A Sbjct: 266 ADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG-------GGYNLANTARCWTYL 318 Query: 318 VQTLLG 323 +LG Sbjct: 319 TGVILG 324 >gi|13128862 histone deacetylase 3 [Homo sapiens] Length = 428 Score = 76.6 bits (187), Expect = 7e-14 Identities = 81/313 (25%), Positives = 134/313 (42%), Gaps = 41/313 (13%) Query: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRE---TQVLG-KEE 82 +P RL + GL ++ + +AS+ ++ HS +Y+ ++ T + G + Sbjct: 25 KPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKS 84 Query: 83 LQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNG-----LALVRPPG-HHG 136 L A + D F P F GA LQ GA Q +A+ G HH Sbjct: 85 LNAFNVGDDCPVF-PGLFEFCSRYTGASLQ-------GATQLNNKICDIAINWAGGLHHA 136 Query: 137 QRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHR 196 ++ A+GFC N++ I + H R+L +D D+HHG G+Q F V+ S+H+ Sbjct: 137 KKFEASGFCYVNDIVIGILELLKYHP--RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHK 194 Query: 197 YEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPE 256 Y G ++ F D VG G + +N+P G+ + Y F ++ + + P Sbjct: 195 Y--GNYF-FPGTGDMYEVGAESGRYYCLNVPLRD-GIDDQSYKHLFQPVINQVVDFYQPT 250 Query: 257 LVLVSAGFDSAIGDPEG----QMQATPECFAHLTQL---LQVLAGGRVCAVLEGGYHLES 309 +++ G DS D G ++ EC ++ L VL G GGY + + Sbjct: 251 CIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG--------GGYTVRN 302 Query: 310 LAESVCMTVQTLL 322 +A C T +T L Sbjct: 303 VAR--CWTYETSL 313 >gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] Length = 347 Score = 68.2 bits (165), Expect = 2e-11 Identities = 77/315 (24%), Positives = 131/315 (41%), Gaps = 36/315 (11%) Query: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97 L++ L + + AREASEE+L +VH+ Y++ ++ + + A + + F P Sbjct: 49 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV------ATITEIPPVIFLP 102 Query: 98 STFHCARLAAGAGLQLVDAVLTG--AVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAA 154 + ++ Q ++ G AV+ G A+ G HH GFC + ++ +A Sbjct: 103 NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAI 162 Query: 155 AHAKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRFWPFLRESD 210 ++ G+ R ++D D H G G + F DD V ++ H Y RF Sbjct: 163 KFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF-------- 214 Query: 211 ADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGD 270 Q + V L W G + +Y+ + E P++V+ +AG D GD Sbjct: 215 -----AKQAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGD 266 Query: 271 PEGQMQATPECFAHLTQLLQVLAGGR---VCAVLEGGYHLESLAESVCMTVQTLLGDPAP 327 G + +P +L+ + GR + V GGY + A + ++ L G Sbjct: 267 RLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFG---L 322 Query: 328 PLSGPMAPCQSALES 342 L GP +P SA S Sbjct: 323 GLIGPESPSVSAQNS 337 >gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] Length = 296 Score = 61.2 bits (147), Expect = 3e-09 Identities = 77/313 (24%), Positives = 126/313 (40%), Gaps = 55/313 (17%) Query: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97 L++ L + + AREASEE+L +VH+ Y++ ++ ++ L+ L Q Sbjct: 21 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK------RKVLRPLRTQTGG----- 69 Query: 98 STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAAAH 156 T +LA V+ G A+ G HH GFC + ++ +A Sbjct: 70 -TIMAGKLA---------------VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKF 113 Query: 157 AKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRFWPFLRESDAD 212 ++ G+ R ++D D H G G + F DD V ++ H Y RF Sbjct: 114 LFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF---------- 163 Query: 213 AVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE 272 Q + V L W G + +Y+ + E P++V+ +AG D GD Sbjct: 164 ---AKQAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 217 Query: 273 GQMQATPECFAHLTQLLQVLAGGR---VCAVLEGGYHLESLAESVCMTVQTLLGDPAPPL 329 G + +P +L+ + GR + V GGY + A + ++ L G L Sbjct: 218 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFG---LGL 273 Query: 330 SGPMAPCQSALES 342 GP +P SA S Sbjct: 274 IGPESPSVSAQNS 286 >gi|222418647 mucin 7, secreted precursor [Homo sapiens] Length = 377 Score = 46.6 bits (109), Expect = 7e-05 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%) Query: 319 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 374 +T P PP + P P SA +A A S + TAVP +PS+ + Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269 Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 433 + P P AA PS+ P PAP TA +TTP+ + L PD + Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326 Query: 434 ASALREET 441 A+ + T Sbjct: 327 AAPTHQTT 334 Score = 37.0 bits (84), Expect = 0.059 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%) Query: 360 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 419 QD TA P +PS+ +P PP P AA PS+ P AP TA T P Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219 Query: 420 DITLVLPPDVIQQEASA 436 T P E +A Sbjct: 220 ATTPAPPSSSAPPETTA 236 Score = 30.4 bits (67), Expect = 5.5 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%) Query: 320 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 379 T P P + P P SA AP S Q + P + + PP Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219 Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 435 P P ++SAP P P PS T L++ P+ T V P P + S Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272 Query: 436 ALREETEAWARP 447 + E A P Sbjct: 273 SASAPPETTAAP 284 >gi|222418649 mucin 7, secreted precursor [Homo sapiens] Length = 377 Score = 46.6 bits (109), Expect = 7e-05 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%) Query: 319 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 374 +T P PP + P P SA +A A S + TAVP +PS+ + Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269 Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 433 + P P AA PS+ P PAP TA +TTP+ + L PD + Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326 Query: 434 ASALREET 441 A+ + T Sbjct: 327 AAPTHQTT 334 Score = 37.0 bits (84), Expect = 0.059 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%) Query: 360 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 419 QD TA P +PS+ +P PP P AA PS+ P AP TA T P Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219 Query: 420 DITLVLPPDVIQQEASA 436 T P E +A Sbjct: 220 ATTPAPPSSSAPPETTA 236 Score = 30.4 bits (67), Expect = 5.5 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%) Query: 320 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 379 T P P + P P SA AP S Q + P + + PP Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219 Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 435 P P ++SAP P P PS T L++ P+ T V P P + S Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272 Query: 436 ALREETEAWARP 447 + E A P Sbjct: 273 SASAPPETTAAP 284 >gi|222418645 mucin 7, secreted precursor [Homo sapiens] Length = 377 Score = 46.6 bits (109), Expect = 7e-05 Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%) Query: 319 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 374 +T P PP + P P SA +A A S + TAVP +PS+ + Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269 Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 433 + P P AA PS+ P PAP TA +TTP+ + L PD + Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326 Query: 434 ASALREET 441 A+ + T Sbjct: 327 AAPTHQTT 334 Score = 37.0 bits (84), Expect = 0.059 Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%) Query: 360 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 419 QD TA P +PS+ +P PP P AA PS+ P AP TA T P Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219 Query: 420 DITLVLPPDVIQQEASA 436 T P E +A Sbjct: 220 ATTPAPPSSSAPPETTA 236 Score = 30.4 bits (67), Expect = 5.5 Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%) Query: 320 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 379 T P P + P P SA AP S Q + P + + PP Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219 Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 435 P P ++SAP P P PS T L++ P+ T V P P + S Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272 Query: 436 ALREETEAWARP 447 + E A P Sbjct: 273 SASAPPETTAAP 284 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 40.8 bits (94), Expect = 0.004 Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 7/96 (7%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 379 P+PP+ P +P S S + +QAP + V + PMSPS+ P PP Sbjct: 669 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728 Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVA 415 PL P + S P+S P P P V +A Sbjct: 729 PL--AAPPLQVPPSPPASPPMSPSATPPPRVPPLLA 762 Score = 35.0 bits (79), Expect = 0.22 Identities = 35/119 (29%), Positives = 48/119 (40%), Gaps = 19/119 (15%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPL--- 381 P+PP S PM+P SA Q+ AP + + + PMSPS+ P PP L Sbjct: 708 PSPPASPPMSP--SATPPPQAPPPLAAPPLQ-VPPSPPASPPMSPSATPPPRVPPLLAAP 764 Query: 382 -----------LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 427 LP P+ K AP +L P L P+ A +P +L + P Sbjct: 765 PLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 823 Score = 33.5 bits (75), Expect = 0.65 Identities = 31/108 (28%), Positives = 43/108 (39%), Gaps = 7/108 (6%) Query: 325 PAP-PLSGPMAPCQSALESIQSARAAQAPH----WKSLQQQDVTAVPMSPSSHSPEGRPP 379 PAP PL P +P + S+ A P S Q + + P+SP + P PP Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPP 623 Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 427 L P +A S P+S P P+P A+A+ PP Sbjct: 624 XL--ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 669 Score = 32.3 bits (72), Expect = 1.5 Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%) Query: 326 APPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGG 385 A P GP++ A S +A P D A P+ P++ P PPL Sbjct: 292 AAPALGPLSSSPLATPSPSGTKARPVP------PPDNAATPL-PATLPPS---PPLATPL 341 Query: 386 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITL-----VLPPDVIQQEASALREE 440 P+ + SAP SL P P + ++TTP + +PP IQ S Sbjct: 342 PLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPP--IQVPHSLTSPS 399 Query: 441 TEAWARPHESLAREEALTALG 461 +A P +L+ +A T+LG Sbjct: 400 LQAPPSP-LALSSLQATTSLG 419 Score = 31.6 bits (70), Expect = 2.5 Identities = 31/106 (29%), Positives = 39/106 (36%), Gaps = 14/106 (13%) Query: 331 GPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEG----RPPPLLPGGP 386 G P +L S SA +P + P PS P+G RPP + P Sbjct: 233 GLQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR- 289 Query: 387 VCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD-----ITLVLPP 427 K AA A L P P+PS A + PD + LPP Sbjct: 290 --KDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPP 333 Score = 31.2 bits (69), Expect = 3.2 Identities = 45/149 (30%), Positives = 55/149 (36%), Gaps = 35/149 (23%) Query: 318 VQTLLGDPAPPLSGPMA--PCQSALESIQSARAAQAP----------HWKSLQQQDVTAV 365 +QT L PLS P+ P Q AL S+ S + QAP SL + Sbjct: 469 LQTSLSPAVSPLSSPLTIHPLQ-ALSSLAS-HSPQAPLSSLIMPPLETQSSLAPPSLQTP 526 Query: 366 PMS----PSSHSPEGRPPPLLPGGPVCKAAASAPSS---LLDQPCLCPAPSVRTAVALTT 418 P S P + P PPPL ASAP + L PC P P LTT Sbjct: 527 PASLTTPPLENLPSLAPPPL--------QTASAPLTTPHLETPPCPAPCPLQAPPSPLTT 578 Query: 419 PDITLVLPPDVIQQEASALREETEAWARP 447 P PP+ A+ + A A P Sbjct: 579 P------PPETPSSIATPPPQAPPALASP 601 Score = 30.4 bits (67), Expect = 5.5 Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 17/117 (14%) Query: 326 APPLSGPMAPCQSALESIQSARAAQAPHWKSL---------QQQDVTAVPMSPSSHSPEG 376 +P L P +P AL S+Q+ + +P ++ Q Q P P+S P+ Sbjct: 397 SPSLQAPPSPL--ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDS 454 Query: 377 RP---PPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDI---TLVLPP 427 P P LP P + + S S L P +++A +P +L++PP Sbjct: 455 PPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPP 511 >gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens] Length = 1374 Score = 40.4 bits (93), Expect = 0.005 Identities = 34/120 (28%), Positives = 45/120 (37%), Gaps = 25/120 (20%) Query: 323 GDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSS----------- 371 G P PL+G + LE + + RAAQ HW+S + + P S Sbjct: 652 GAPPLPLTG-----EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAE 706 Query: 372 ------HSPEGRPPPLLPGGPVC---KAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT 422 +P P P PG P+ A+A P P LC A + A L TP T Sbjct: 707 GCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWT 766 >gi|239754940 PREDICTED: hypothetical protein [Homo sapiens] Length = 159 Score = 40.0 bits (92), Expect = 0.007 Identities = 35/108 (32%), Positives = 44/108 (40%), Gaps = 21/108 (19%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKS------------------LQQQDVTAVP 366 PAP + P AP + + SA AA P +S LQ + AVP Sbjct: 50 PAPAAAHPPAPRERPAAARLSALAAAQPRRRSPGPQGGGGGDIASPLPPALQPRGAPAVP 109 Query: 367 MSPSSHSPEGRP---PPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVR 411 +PS RP PP P PV A +S P+ Q PAPS+R Sbjct: 110 AAPSPGPLPARPSSPPPSPPSPPVPTAQSSLPAPWPPQGPRSPAPSLR 157 >gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 855 Score = 38.9 bits (89), Expect = 0.016 Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 8/111 (7%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 379 P+PP+ P +P S S + +QAP + V + PMSPS+ P PP Sbjct: 444 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 503 Query: 380 PL-LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 427 PL P + K AP +L P L P+ A +P +L + P Sbjct: 504 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 554 Score = 30.8 bits (68), Expect = 4.2 Identities = 28/96 (29%), Positives = 37/96 (38%), Gaps = 13/96 (13%) Query: 326 APPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGG 385 A P GP++ A S +A +QAP + A P S S P PL P Sbjct: 292 AAPALGPLSSSPLATPSPSAALQSQAP-------PTLPATPHSSSLTCQLATPLPLAPPS 344 Query: 386 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDI 421 P SAP SL P P + +L +P + Sbjct: 345 P------SAPPSLQTLPSPPATPPSQATTSLGSPTL 374 >gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens] Length = 816 Score = 38.9 bits (89), Expect = 0.016 Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 8/111 (7%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 379 P+PP+ P +P S S + +QAP + V + PMSPS+ P PP Sbjct: 405 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464 Query: 380 PL-LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 427 PL P + K AP +L P L P+ A +P +L + P Sbjct: 465 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 515 Score = 30.4 bits (67), Expect = 5.5 Identities = 30/109 (27%), Positives = 40/109 (36%), Gaps = 9/109 (8%) Query: 331 GPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEG----RPPPLLPGGP 386 G P +L S SA +P + P PS P+G RPP + P Sbjct: 224 GLQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR- 280 Query: 387 VCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEAS 435 K AA A L P P+PS + + TL PP +A+ Sbjct: 281 --KDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327 >gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo sapiens] Length = 1560 Score = 38.9 bits (89), Expect = 0.016 Identities = 44/174 (25%), Positives = 61/174 (35%), Gaps = 13/174 (7%) Query: 324 DPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLP 383 +PAP GP P APH A SS P P Sbjct: 849 NPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQL 908 Query: 384 GGPVCKAAASAPSS-----LLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQ---QEAS 435 P + +P+ L+ +P P P RT +TTP L P +++ Q S Sbjct: 909 QFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPS 968 Query: 436 ALREETEAWARPHESLAREEALTALGKLLYLLDGML-DGQVNSGIAATPASAAA 488 + + +A P A + T+LG L +L GQ SG P+ A A Sbjct: 969 GIILQNKAGGAP----AAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPA 1018 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 38.5 bits (88), Expect = 0.020 Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 10/114 (8%) Query: 306 HLESLAESVCMTVQ---TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV 362 HL + E +C+ Q L GD AP S P ++A + SA + +P + + Sbjct: 628 HLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK- 686 Query: 363 TAVPMSPSSHSPE-GRPPPL-----LPGGPVCKAAASAPSSLLDQPCLCPAPSV 410 A P S +PE +PPPL L G P KA + L +P PSV Sbjct: 687 DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 38.5 bits (88), Expect = 0.020 Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 10/114 (8%) Query: 306 HLESLAESVCMTVQ---TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV 362 HL + E +C+ Q L GD AP S P ++A + SA + +P + + Sbjct: 628 HLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK- 686 Query: 363 TAVPMSPSSHSPE-GRPPPL-----LPGGPVCKAAASAPSSLLDQPCLCPAPSV 410 A P S +PE +PPPL L G P KA + L +P PSV Sbjct: 687 DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740 >gi|116284392 mucin 2 precursor [Homo sapiens] Length = 5179 Score = 36.6 bits (83), Expect = 0.077 Identities = 26/103 (25%), Positives = 39/103 (37%), Gaps = 4/103 (3%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPG 384 P+PP + P+ P S + + P + T P P++ +P PP + Sbjct: 1539 PSPPTTTPITPPTSTTTLPPTTTPSPPP--TTTTTPPPTTTPSPPTTTTPS--PPTITTT 1594 Query: 385 GPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 427 P S P++ P PS T +T P T LPP Sbjct: 1595 TPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP 1637 Score = 32.3 bits (72), Expect = 1.5 Identities = 27/118 (22%), Positives = 39/118 (33%), Gaps = 8/118 (6%) Query: 315 CMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSP 374 C + + P+PP + P P S + +P + T P SP + Sbjct: 1389 CWPMDKCITTPSPPTTTPSPPPTST--TTLPPTTTPSPPTTTTTTPPPTTTP-SPPITTT 1445 Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPA-----PSVRTAVALTTPDITLVLPP 427 PP P P+ P++ P P+ PS T T P T PP Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPP 1503 Score = 30.4 bits (67), Expect = 5.5 Identities = 24/108 (22%), Positives = 37/108 (34%), Gaps = 6/108 (5%) Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPE-----GRPP 379 P+PP + P+ P S + + P + T P + ++ SP PP Sbjct: 1618 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPP 1677 Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 427 P P+ S P++ + P PS T T PP Sbjct: 1678 TTTPSSPIT-TTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPP 1724 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 28,911,044 Number of Sequences: 37866 Number of extensions: 1456516 Number of successful extensions: 6294 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 34 Number of HSP's successfully gapped in prelim test: 152 Number of HSP's that attempted gapping in prelim test: 5983 Number of HSP's gapped (non-prelim): 387 length of query: 669 length of database: 18,247,518 effective HSP length: 109 effective length of query: 560 effective length of database: 14,120,124 effective search space: 7907269440 effective search space used: 7907269440 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.