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Search of human proteins with 20070354
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 1347 0.0
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 1296 0.0
gi|13128864 histone deacetylase 6 [Homo sapiens] 407 e-113
gi|153085395 histone deacetylase 4 [Homo sapiens] 238 2e-62
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 236 7e-62
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 236 7e-62
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 235 9e-62
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 235 9e-62
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 232 7e-61
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 232 7e-61
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 226 5e-59
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 140 5e-33
gi|13128860 histone deacetylase 1 [Homo sapiens] 96 1e-19
gi|116284376 histone deacetylase 2 [Homo sapiens] 95 2e-19
gi|8923769 histone deacetylase 8 [Homo sapiens] 92 2e-18
gi|13128862 histone deacetylase 3 [Homo sapiens] 77 7e-14
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 68 2e-11
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 61 3e-09
gi|222418647 mucin 7, secreted precursor [Homo sapiens] 47 7e-05
gi|222418649 mucin 7, secreted precursor [Homo sapiens] 47 7e-05
gi|222418645 mucin 7, secreted precursor [Homo sapiens] 47 7e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 41 0.004
gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens] 40 0.005
gi|239754940 PREDICTED: hypothetical protein [Homo sapiens] 40 0.007
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 39 0.016
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 39 0.016
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho... 39 0.016
gi|150170670 piccolo isoform 2 [Homo sapiens] 39 0.020
gi|150378539 piccolo isoform 1 [Homo sapiens] 39 0.020
gi|116284392 mucin 2 precursor [Homo sapiens] 37 0.077
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 1347 bits (3487), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
Sbjct: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60
Query: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
Sbjct: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120
Query: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
Sbjct: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
Query: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
Sbjct: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240
Query: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
Sbjct: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300
Query: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
Sbjct: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360
Query: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
Sbjct: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420
Query: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
Sbjct: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480
Query: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
Sbjct: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540
Query: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
Sbjct: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600
Query: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
Sbjct: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660
Query: 661 LQCHPHLVA 669
LQCHPHLVA
Sbjct: 661 LQCHPHLVA 669
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 1296 bits (3354), Expect = 0.0
Identities = 649/669 (97%), Positives = 649/669 (97%), Gaps = 20/669 (2%)
Query: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
Sbjct: 1 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL 60
Query: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
Sbjct: 61 GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG 120
Query: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
Sbjct: 121 AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ 180
Query: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
Sbjct: 181 YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA 240
Query: 241 AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV 300
AFLHLLLPLAFE GQMQATPECFAHLTQLLQVLAGGRVCAV
Sbjct: 241 AFLHLLLPLAFE--------------------GQMQATPECFAHLTQLLQVLAGGRVCAV 280
Query: 301 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 360
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
Sbjct: 281 LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ 340
Query: 361 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 420
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
Sbjct: 341 DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD 400
Query: 421 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 480
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
Sbjct: 401 ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA 460
Query: 481 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 540
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
Sbjct: 461 ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS 520
Query: 541 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 600
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
Sbjct: 521 MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL 580
Query: 601 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
Sbjct: 581 AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 640
Query: 661 LQCHPHLVA 669
LQCHPHLVA
Sbjct: 641 LQCHPHLVA 649
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 407 bits (1046), Expect = e-113
Identities = 203/388 (52%), Positives = 267/388 (68%), Gaps = 8/388 (2%)
Query: 2 GTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELG 61
GT LV E + LWDD E PERL A ++L Q GL RC+ AR A +EEL
Sbjct: 85 GTGLVLDEQLNEFHCLWDDSFPE--GPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELM 142
Query: 62 LVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGA 121
LVHS EY+ L+ TQ + + EL+ L+ +D++Y HP+++ CA LA+G+ L+LVDAVL
Sbjct: 143 LVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAE 202
Query: 122 VQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQY 181
++NG+A++RPPGHH Q + +G+C+FN+VA+AA +A+QKH + R+L+VDWDVHHGQG Q+
Sbjct: 203 IRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQF 262
Query: 182 LFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAA 241
F+ DPSVLYFS HRYE GRFWP L+ S+ G GQG G+T+N+PWNQVGM +ADY+AA
Sbjct: 263 TFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAA 322
Query: 242 FLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVL 301
FLH+LLP+A EF P+LVLV+AGFD+ GDP+G+M ATP FA LT LL LAGG++ L
Sbjct: 323 FLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSL 382
Query: 302 EGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQD 361
EGGY+L +LAE V ++ TLLGDP P L P APC+SA S+ A A P W+ L +
Sbjct: 383 EGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRST 442
Query: 362 VTA----VPMSPSSHSPEGRP--PPLLP 383
T + S E P PP+LP
Sbjct: 443 ETVERDNMEEDNVEESEEEGPWEPPVLP 470
Score = 361 bits (926), Expect = 1e-99
Identities = 188/361 (52%), Positives = 241/361 (66%), Gaps = 3/361 (0%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T LVY ++M LWD E+ P+R+ + RL + GL RCL L+ R A+E EL
Sbjct: 481 TGLVYDQNMMNHCNLWDSHHPEV--PQRILRIMCRLEELGLAGRCLTLTPRPATEAELLT 538
Query: 63 VHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAV 122
HS EYV +R T+ + EL S FD+IY PSTF CA+LA GA +LV+AVL+G V
Sbjct: 539 CHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEV 598
Query: 123 QNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHG-LHRILVVDWDVHHGQGIQY 181
NG A+VRPPGHH ++ AA GFC FN+VA+AA HA+ G RIL+VDWDVHHG G Q+
Sbjct: 599 LNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQH 658
Query: 182 LFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAA 241
+FEDDPSVLY S HRY+HG F+P E + +GR G GFTVN+ WN MG+ADY+AA
Sbjct: 659 MFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAA 718
Query: 242 FLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVL 301
+ L+LP+A+EF+PELVLVSAGFD+A GDP G Q +PE +AHLT LL LA GR+ +L
Sbjct: 719 WHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILIL 778
Query: 302 EGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQD 361
EGGY+L S++ES+ ++LLGDP P L+ P P AL SI +W+SL+
Sbjct: 779 EGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMK 838
Query: 362 V 362
V
Sbjct: 839 V 839
Score = 43.1 bits (100), Expect = 8e-04
Identities = 34/85 (40%), Positives = 43/85 (50%), Gaps = 13/85 (15%)
Query: 562 LVLPLAYGFQPDLVLVALG-------PGHGLQ-GPHA-ALLAAMLRGLAGGRVLALLEE- 611
LVLP+AY F P+LVLV+ G P G Q P A L +L GLA GR++ +LE
Sbjct: 722 LVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGG 781
Query: 612 ---NSTPQLAGILARVLNGEAPPSL 633
S + R L G+ PP L
Sbjct: 782 YNLTSISESMAACTRSLLGDPPPLL 806
Score = 41.2 bits (95), Expect = 0.003
Identities = 38/121 (31%), Positives = 55/121 (45%), Gaps = 15/121 (12%)
Query: 555 FLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAA----------MLRGLAGGR 604
+++ L ++LP+A FQP LVLVA G LQG +AA +L GLAGG+
Sbjct: 319 YIAAFLHVLLPVALEFQPQLVLVAAG-FDALQGDPKGEMAATPAGFAQLTHLLMGLAGGK 377
Query: 605 VLALLE--ENSTPQLAGILA--RVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM 660
++ LE N G+ A L G+ P L ++ LEP W++
Sbjct: 378 LILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEV 437
Query: 661 L 661
L
Sbjct: 438 L 438
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 238 bits (606), Expect = 2e-62
Identities = 144/387 (37%), Positives = 209/387 (54%), Gaps = 27/387 (6%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T LVY M + E R+ + RL++ GL +C + R+A+ EEL
Sbjct: 654 TGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQT 713
Query: 63 VHSPEYVSL-----VRETQVLGKEELQALSGQF------------DAIYFHPSTFHCARL 105
VHS + L + ++ K+ L +L+ F D I+ + ARL
Sbjct: 714 VHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARL 773
Query: 106 AAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHR 165
A G ++LV V TG ++NG A+VRPPGHH + + GFC FN+VA+AA +Q+ + +
Sbjct: 774 AVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSK 833
Query: 166 ILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVN 225
IL+VDWDVHHG G Q F DPSVLY S HRY+ G F+P D VG G G+GF VN
Sbjct: 834 ILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFP--GSGAPDEVGTGPGVGFNVN 891
Query: 226 LPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATPE 280
+ + MG+A+Y+AAF +++P+A EF P++VLVS+GFD+ G P G +
Sbjct: 892 MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAR 951
Query: 281 CFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLG---DPAPPLSGPMAPCQ 337
CF +LT+ L LAGGR+ LEGG+ L ++ ++ V LLG DP P P
Sbjct: 952 CFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA 1011
Query: 338 SALESIQSARAAQAPHWKSLQQQDVTA 364
+A+ S++ + +W+ LQ+ TA
Sbjct: 1012 NAVRSMEKVMEIHSKYWRCLQRTTSTA 1038
Score = 37.7 bits (86), Expect = 0.035
Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597
P+ +L+ +V+P+A F PD+VLV+ G G+ L L L
Sbjct: 901 PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL 960
Query: 598 RGLAGGRVLALLE 610
GLAGGR++ LE
Sbjct: 961 MGLAGGRIVLALE 973
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 236 bits (601), Expect = 7e-62
Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 636 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 695
Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 696 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 754
Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 755 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 814
Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 815 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 872
Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
+N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T
Sbjct: 873 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 932
Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 933 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 992
Query: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366
+A+ S+Q Q+ +WKS++ + AVP
Sbjct: 993 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1020
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 236 bits (601), Expect = 7e-62
Identities = 143/391 (36%), Positives = 213/391 (54%), Gaps = 33/391 (8%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869
Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
+N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T
Sbjct: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929
Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989
Query: 336 CQSALESIQSARAAQAPHWKSLQQQDVTAVP 366
+A+ S+Q Q+ +WKS++ + AVP
Sbjct: 990 NMNAVISLQKIIEIQSKYWKSVR---MVAVP 1017
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 235 bits (600), Expect = 9e-62
Identities = 134/384 (34%), Positives = 207/384 (53%), Gaps = 30/384 (7%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T +VY M + + + E R+ + RL++ GL +C R+ R+A+ +E+
Sbjct: 684 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 743
Query: 63 VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103
VHS EY +L+ T L +++L + + D ++ +
Sbjct: 744 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 802
Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
R+A G L+L V G ++NG A++RPPGHH + + A GFC FN+VAI A +QK +
Sbjct: 803 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 862
Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
++L+VDWD+HHG G Q F +DPSVLY S HRY++G F+P + VG G G+G+
Sbjct: 863 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 920
Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
VN+ W +G+ +Y+ AF +++P+A EF P++VLVSAGFD+ G P G T
Sbjct: 921 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 980
Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
CF HLT+ L LAGGRV LEGG+ L ++ ++ V LL PL + P
Sbjct: 981 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1040
Query: 336 CQSALESIQSARAAQAPHWKSLQQ 359
+A+ +++ Q+ HW +Q+
Sbjct: 1041 NINAVATLEKVIEIQSKHWSCVQK 1064
Score = 34.7 bits (78), Expect = 0.29
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597
P+ +L+ +V+P+A+ F PD+VLV+ G G+ + L L
Sbjct: 932 PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 991
Query: 598 RGLAGGRVLALLE 610
LAGGRV+ LE
Sbjct: 992 MTLAGGRVVLALE 1004
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 235 bits (600), Expect = 9e-62
Identities = 134/384 (34%), Positives = 207/384 (53%), Gaps = 30/384 (7%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T +VY M + + + E R+ + RL++ GL +C R+ R+A+ +E+
Sbjct: 683 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 742
Query: 63 VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103
VHS EY +L+ T L +++L + + D ++ +
Sbjct: 743 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 801
Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
R+A G L+L V G ++NG A++RPPGHH + + A GFC FN+VAI A +QK +
Sbjct: 802 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 861
Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
++L+VDWD+HHG G Q F +DPSVLY S HRY++G F+P + VG G G+G+
Sbjct: 862 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 919
Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
VN+ W +G+ +Y+ AF +++P+A EF P++VLVSAGFD+ G P G T
Sbjct: 920 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 979
Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
CF HLT+ L LAGGRV LEGG+ L ++ ++ V LL PL + P
Sbjct: 980 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1039
Query: 336 CQSALESIQSARAAQAPHWKSLQQ 359
+A+ +++ Q+ HW +Q+
Sbjct: 1040 NINAVATLEKVIEIQSKHWSCVQK 1063
Score = 34.7 bits (78), Expect = 0.29
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597
P+ +L+ +V+P+A+ F PD+VLV+ G G+ + L L
Sbjct: 931 PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 990
Query: 598 RGLAGGRVLALLE 610
LAGGRV+ LE
Sbjct: 991 MTLAGGRVVLALE 1003
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 232 bits (592), Expect = 7e-61
Identities = 145/383 (37%), Positives = 202/383 (52%), Gaps = 28/383 (7%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T L+Y M + D E R+ + RL++RGL +C L R+AS EEL
Sbjct: 522 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 581
Query: 63 VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104
VHS +V L + L +L L Q D I+ + + AR
Sbjct: 582 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 641
Query: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164
AAG+ L V + ++NG A+VRPPGHH + A GFC FN+VAIA +Q+
Sbjct: 642 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 701
Query: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224
+IL+VDWDVHHG G Q F DPSVLY S HR++ G F+P D VG G G GF V
Sbjct: 702 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 759
Query: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATP 279
N+ W MG+ +Y+AAF +++P+A EF P+LVLVSAGFD+A G P G +
Sbjct: 760 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 819
Query: 280 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 336
+CF ++TQ L LAGG V LEGG+ L ++ ++ V LLG+ PLS P
Sbjct: 820 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 879
Query: 337 QSALESIQSARAAQAPHWKSLQQ 359
+A+ S+++ + +W +Q+
Sbjct: 880 LNAIRSLEAVIRVHSKYWGCMQR 902
Score = 33.1 bits (74), Expect = 0.85
Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)
Query: 555 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 603
+L+ +V+P+A F PDLVLV+ G GH L G H + + L LAGG
Sbjct: 776 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 835
Query: 604 RVLALLE 610
V+ LE
Sbjct: 836 AVVLALE 842
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 232 bits (592), Expect = 7e-61
Identities = 145/383 (37%), Positives = 202/383 (52%), Gaps = 28/383 (7%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T L+Y M + D E R+ + RL++RGL +C L R+AS EEL
Sbjct: 559 TGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQS 618
Query: 63 VHSPEYVSLVRETQV----LGKEELQALSGQ--------------FDAIYFHPSTFHCAR 104
VHS +V L + L +L L Q D I+ + + AR
Sbjct: 619 VHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAAR 678
Query: 105 LAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLH 164
AAG+ L V + ++NG A+VRPPGHH + A GFC FN+VAIA +Q+
Sbjct: 679 WAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKAS 738
Query: 165 RILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTV 224
+IL+VDWDVHHG G Q F DPSVLY S HR++ G F+P D VG G G GF V
Sbjct: 739 KILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFP--GSGAVDEVGAGSGEGFNV 796
Query: 225 NLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATP 279
N+ W MG+ +Y+AAF +++P+A EF P+LVLVSAGFD+A G P G +
Sbjct: 797 NVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSA 856
Query: 280 ECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLS---GPMAPC 336
+CF ++TQ L LAGG V LEGG+ L ++ ++ V LLG+ PLS P
Sbjct: 857 KCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPN 916
Query: 337 QSALESIQSARAAQAPHWKSLQQ 359
+A+ S+++ + +W +Q+
Sbjct: 917 LNAIRSLEAVIRVHSKYWGCMQR 939
Score = 33.1 bits (74), Expect = 0.85
Identities = 25/67 (37%), Positives = 34/67 (50%), Gaps = 11/67 (16%)
Query: 555 FLSCILGLVLPLAYGFQPDLVLVALG----PGH--GLQGPHAA-----LLAAMLRGLAGG 603
+L+ +V+P+A F PDLVLV+ G GH L G H + + L LAGG
Sbjct: 813 YLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG 872
Query: 604 RVLALLE 610
V+ LE
Sbjct: 873 AVVLALE 879
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 226 bits (576), Expect = 5e-59
Identities = 136/369 (36%), Positives = 201/369 (54%), Gaps = 30/369 (8%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P + VG G G G+
Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP--GSGAPNEVGTGLGEGYN 869
Query: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
+N+ W MG+ +Y+ AF ++ P+A EFDP++VLVSAGFD+ G P G + T
Sbjct: 870 INIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVT 929
Query: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
+CF HLT+ L LA GRV LEGG+ L ++ ++ V LLG+ PL+ + +P
Sbjct: 930 AKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSP 989
Query: 336 CQSALESIQ 344
+A+ S+Q
Sbjct: 990 NMNAVISLQ 998
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 140 bits (352), Expect = 5e-33
Identities = 80/221 (36%), Positives = 117/221 (52%), Gaps = 20/221 (9%)
Query: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
T + Y M + + + E R+ + RL++ GL +C R+ R+AS EE+ L
Sbjct: 633 TGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQL 692
Query: 63 VHSPEYVSLVRETQVLGKEELQ-------------------ALSGQFDAIYFHPSTFHCA 103
VHS E+ SL+ T L ++L L D I+ + A
Sbjct: 693 VHS-EHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAA 751
Query: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
R+A G ++L V +G ++NG A+VRPPGHH + + A GFC FN+VAI A + + + +
Sbjct: 752 RMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNI 811
Query: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWP 204
+IL+VD DVHHG G Q F DPS+LY S HRY+ G F+P
Sbjct: 812 SKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 95.5 bits (236), Expect = 1e-19
Identities = 80/304 (26%), Positives = 134/304 (44%), Gaps = 28/304 (9%)
Query: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86
+P R+ + L GL ++ +A+ EE+ HS +Y+ +R + E
Sbjct: 31 KPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQ 90
Query: 87 SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142
+F+ P F +L+ G + AV Q +A+ G HH +++ A+
Sbjct: 91 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--ASAVKLNKQQTDIAVNWAGGLHHAKKSEAS 148
Query: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
GFC N++ +A + H R+L +D D+HHG G++ F V+ S+H+Y G +
Sbjct: 149 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 204
Query: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSA 262
+P D +G G+G + VN P G+ + Y A F ++ + F P V++
Sbjct: 205 FP--GTGDLRDIGAGKGKYYAVNYPLRD-GIDDESYEAIFKPVMSKVMEMFQPSAVVLQC 261
Query: 263 GFDSAIGDPEGQMQAT----PEC--FAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCM 316
G DS GD G T +C F L ++ GG GGY + ++A C
Sbjct: 262 GSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG-------GGYTIRNVAR--CW 312
Query: 317 TVQT 320
T +T
Sbjct: 313 TYET 316
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 94.7 bits (234), Expect = 2e-19
Identities = 77/304 (25%), Positives = 135/304 (44%), Gaps = 28/304 (9%)
Query: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQAL 86
+P R+ + L GL ++ +A+ EE+ HS EY+ +R + E
Sbjct: 126 KPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQ 185
Query: 87 SGQFDAIYFHP---STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAAN 142
+F+ P F +L+ G + AV Q +A+ G HH +++ A+
Sbjct: 186 MQRFNVGEDCPVFDGLFEFCQLSTGGSV--AGAVKLNRQQTDMAVNWAGGLHHAKKSEAS 243
Query: 143 GFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRF 202
GFC N++ +A + H R+L +D D+HHG G++ F V+ S+H+Y G +
Sbjct: 244 GFCYVNDIVLAILELLKYH--QRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEY 299
Query: 203 WPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSA 262
+P D +G G+G + VN P G+ + Y F ++ + + P V++
Sbjct: 300 FP--GTGDLRDIGAGKGKYYAVNFPMRD-GIDDESYGQIFKPIISKVMEMYQPSAVVLQC 356
Query: 263 GFDSAIGDPEGQMQATPECFAHLTQLLQ------VLAGGRVCAVLEGGYHLESLAESVCM 316
G DS GD G T + A ++++ ++ GG GGY + ++A C
Sbjct: 357 GADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGG-------GGYTIRNVAR--CW 407
Query: 317 TVQT 320
T +T
Sbjct: 408 TYET 411
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 91.7 bits (226), Expect = 2e-18
Identities = 80/306 (26%), Positives = 139/306 (45%), Gaps = 26/306 (8%)
Query: 28 PERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALS 87
P+R + + L ++ + + AS EE+ H+ Y+ +++ G ++ S
Sbjct: 35 PKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDD-HPDS 93
Query: 88 GQFDAIYFHPST---FHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANG 143
++ Y P+T F A GA + ++ G + +A+ G HH ++ A+G
Sbjct: 94 IEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK--VAINWSGGWHHAKKDEASG 151
Query: 144 FCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFW 203
FC N+ + ++K RIL VD D+HHG G++ F V+ S H++ G F+
Sbjct: 152 FCYLNDAVLGILRLRRK--FERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FF 208
Query: 204 PFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAG 263
P D VG G+G ++VN+P Q G+ + Y +L + F+P+ V++ G
Sbjct: 209 P--GTGDVSDVGLGKGRYYSVNVP-IQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLG 265
Query: 264 FDSAIGDPEGQMQATP----ECFAHLT--QLLQVLAGGRVCAVLEGGYHLESLAESVCMT 317
D+ GDP TP +C ++ QL ++ GG GGY+L + A
Sbjct: 266 ADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGG-------GGYNLANTARCWTYL 318
Query: 318 VQTLLG 323
+LG
Sbjct: 319 TGVILG 324
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 76.6 bits (187), Expect = 7e-14
Identities = 81/313 (25%), Positives = 134/313 (42%), Gaps = 41/313 (13%)
Query: 27 RPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRE---TQVLG-KEE 82
+P RL + GL ++ + +AS+ ++ HS +Y+ ++ T + G +
Sbjct: 25 KPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKS 84
Query: 83 LQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNG-----LALVRPPG-HHG 136
L A + D F P F GA LQ GA Q +A+ G HH
Sbjct: 85 LNAFNVGDDCPVF-PGLFEFCSRYTGASLQ-------GATQLNNKICDIAINWAGGLHHA 136
Query: 137 QRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHR 196
++ A+GFC N++ I + H R+L +D D+HHG G+Q F V+ S+H+
Sbjct: 137 KKFEASGFCYVNDIVIGILELLKYHP--RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHK 194
Query: 197 YEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPE 256
Y G ++ F D VG G + +N+P G+ + Y F ++ + + P
Sbjct: 195 Y--GNYF-FPGTGDMYEVGAESGRYYCLNVPLRD-GIDDQSYKHLFQPVINQVVDFYQPT 250
Query: 257 LVLVSAGFDSAIGDPEG----QMQATPECFAHLTQL---LQVLAGGRVCAVLEGGYHLES 309
+++ G DS D G ++ EC ++ L VL G GGY + +
Sbjct: 251 CIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGG--------GGYTVRN 302
Query: 310 LAESVCMTVQTLL 322
+A C T +T L
Sbjct: 303 VAR--CWTYETSL 313
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 68.2 bits (165), Expect = 2e-11
Identities = 77/315 (24%), Positives = 131/315 (41%), Gaps = 36/315 (11%)
Query: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
L++ L + + AREASEE+L +VH+ Y++ ++ + + A + + F P
Sbjct: 49 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAV------ATITEIPPVIFLP 102
Query: 98 STFHCARLAAGAGLQLVDAVLTG--AVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAA 154
+ ++ Q ++ G AV+ G A+ G HH GFC + ++ +A
Sbjct: 103 NFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAI 162
Query: 155 AHAKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRFWPFLRESD 210
++ G+ R ++D D H G G + F DD V ++ H Y RF
Sbjct: 163 KFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF-------- 214
Query: 211 ADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGD 270
Q + V L W G + +Y+ + E P++V+ +AG D GD
Sbjct: 215 -----AKQAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGD 266
Query: 271 PEGQMQATPECFAHLTQLLQVLAGGR---VCAVLEGGYHLESLAESVCMTVQTLLGDPAP 327
G + +P +L+ + GR + V GGY + A + ++ L G
Sbjct: 267 RLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFG---L 322
Query: 328 PLSGPMAPCQSALES 342
L GP +P SA S
Sbjct: 323 GLIGPESPSVSAQNS 337
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 61.2 bits (147), Expect = 3e-09
Identities = 77/313 (24%), Positives = 126/313 (40%), Gaps = 55/313 (17%)
Query: 38 LRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHP 97
L++ L + + AREASEE+L +VH+ Y++ ++ ++ L+ L Q
Sbjct: 21 LKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELK------RKVLRPLRTQTGG----- 69
Query: 98 STFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPG-HHGQRAAANGFCVFNNVAIAAAH 156
T +LA V+ G A+ G HH GFC + ++ +A
Sbjct: 70 -TIMAGKLA---------------VERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKF 113
Query: 157 AKQK-HGLHRILVVDWDVHHGQGIQYLFEDDPSVL---YFSWHRYEHGRFWPFLRESDAD 212
++ G+ R ++D D H G G + F DD V ++ H Y RF
Sbjct: 114 LFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRF---------- 163
Query: 213 AVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPE 272
Q + V L W G + +Y+ + E P++V+ +AG D GD
Sbjct: 164 ---AKQAIRRKVELEW---GTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRL 217
Query: 273 GQMQATPECFAHLTQLLQVLAGGR---VCAVLEGGYHLESLAESVCMTVQTLLGDPAPPL 329
G + +P +L+ + GR + V GGY + A + ++ L G L
Sbjct: 218 GGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQ-KRTARIIADSILNLFG---LGL 273
Query: 330 SGPMAPCQSALES 342
GP +P SA S
Sbjct: 274 IGPESPSVSAQNS 286
>gi|222418647 mucin 7, secreted precursor [Homo sapiens]
Length = 377
Score = 46.6 bits (109), Expect = 7e-05
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%)
Query: 319 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 374
+T P PP + P P SA +A A S + TAVP +PS+ +
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269
Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 433
+ P P AA PS+ P PAP TA +TTP+ + L PD +
Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326
Query: 434 ASALREET 441
A+ + T
Sbjct: 327 AAPTHQTT 334
Score = 37.0 bits (84), Expect = 0.059
Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%)
Query: 360 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 419
QD TA P +PS+ +P PP P AA PS+ P AP TA T P
Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219
Query: 420 DITLVLPPDVIQQEASA 436
T P E +A
Sbjct: 220 ATTPAPPSSSAPPETTA 236
Score = 30.4 bits (67), Expect = 5.5
Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%)
Query: 320 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 379
T P P + P P SA AP S Q + P + + PP
Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219
Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 435
P P ++SAP P P PS T L++ P+ T V P P + S
Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272
Query: 436 ALREETEAWARP 447
+ E A P
Sbjct: 273 SASAPPETTAAP 284
>gi|222418649 mucin 7, secreted precursor [Homo sapiens]
Length = 377
Score = 46.6 bits (109), Expect = 7e-05
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%)
Query: 319 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 374
+T P PP + P P SA +A A S + TAVP +PS+ +
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269
Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 433
+ P P AA PS+ P PAP TA +TTP+ + L PD +
Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326
Query: 434 ASALREET 441
A+ + T
Sbjct: 327 AAPTHQTT 334
Score = 37.0 bits (84), Expect = 0.059
Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%)
Query: 360 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 419
QD TA P +PS+ +P PP P AA PS+ P AP TA T P
Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219
Query: 420 DITLVLPPDVIQQEASA 436
T P E +A
Sbjct: 220 ATTPAPPSSSAPPETTA 236
Score = 30.4 bits (67), Expect = 5.5
Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%)
Query: 320 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 379
T P P + P P SA AP S Q + P + + PP
Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219
Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 435
P P ++SAP P P PS T L++ P+ T V P P + S
Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272
Query: 436 ALREETEAWARP 447
+ E A P
Sbjct: 273 SASAPPETTAAP 284
>gi|222418645 mucin 7, secreted precursor [Homo sapiens]
Length = 377
Score = 46.6 bits (109), Expect = 7e-05
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 8/128 (6%)
Query: 319 QTLLGDPAPPLSGPMAPCQSALESIQSA----RAAQAPHWKSLQQQDVTAVPMSPSSHSP 374
+T P PP + P P SA +A A S + TAVP +PS+ +
Sbjct: 210 ETTAAPPTPPATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTL 269
Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT-LVLPPDVIQQE 433
+ P P AA PS+ P PAP TA +TTP+ + L PD +
Sbjct: 270 D---PSSASAPPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETS 326
Query: 434 ASALREET 441
A+ + T
Sbjct: 327 AAPTHQTT 334
Score = 37.0 bits (84), Expect = 0.059
Identities = 26/77 (33%), Positives = 31/77 (40%), Gaps = 3/77 (3%)
Query: 360 QDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTP 419
QD TA P +PS+ +P PP P AA PS+ P AP TA T P
Sbjct: 163 QDTTAAPPTPSATTPA---PPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219
Query: 420 DITLVLPPDVIQQEASA 436
T P E +A
Sbjct: 220 ATTPAPPSSSAPPETTA 236
Score = 30.4 bits (67), Expect = 5.5
Identities = 34/132 (25%), Positives = 45/132 (34%), Gaps = 16/132 (12%)
Query: 320 TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPP 379
T P P + P P SA AP S Q + P + + PP
Sbjct: 165 TTAAPPTPSATTPAPPSSSA-----PPETTAAPPTPSATTQAPPSSSAPPETTAAPPTPP 219
Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTT---PDITLVLP-PDVIQQEAS 435
P P ++SAP P P PS T L++ P+ T V P P + S
Sbjct: 220 ATTPAPP----SSSAPPETTAAP---PTPSATTPAPLSSSAPPETTAVPPTPSATTLDPS 272
Query: 436 ALREETEAWARP 447
+ E A P
Sbjct: 273 SASAPPETTAAP 284
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 40.8 bits (94), Expect = 0.004
Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 379
P+PP+ P +P S S + +QAP + V + PMSPS+ P PP
Sbjct: 669 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728
Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVA 415
PL P + S P+S P P P V +A
Sbjct: 729 PL--AAPPLQVPPSPPASPPMSPSATPPPRVPPLLA 762
Score = 35.0 bits (79), Expect = 0.22
Identities = 35/119 (29%), Positives = 48/119 (40%), Gaps = 19/119 (15%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPL--- 381
P+PP S PM+P SA Q+ AP + + + PMSPS+ P PP L
Sbjct: 708 PSPPASPPMSP--SATPPPQAPPPLAAPPLQ-VPPSPPASPPMSPSATPPPRVPPLLAAP 764
Query: 382 -----------LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 427
LP P+ K AP +L P L P+ A +P +L + P
Sbjct: 765 PLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 823
Score = 33.5 bits (75), Expect = 0.65
Identities = 31/108 (28%), Positives = 43/108 (39%), Gaps = 7/108 (6%)
Query: 325 PAP-PLSGPMAPCQSALESIQSARAAQAPH----WKSLQQQDVTAVPMSPSSHSPEGRPP 379
PAP PL P +P + S+ A P S Q + + P+SP + P PP
Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPP 623
Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 427
L P +A S P+S P P+P A+A+ PP
Sbjct: 624 XL--ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 669
Score = 32.3 bits (72), Expect = 1.5
Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%)
Query: 326 APPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGG 385
A P GP++ A S +A P D A P+ P++ P PPL
Sbjct: 292 AAPALGPLSSSPLATPSPSGTKARPVP------PPDNAATPL-PATLPPS---PPLATPL 341
Query: 386 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITL-----VLPPDVIQQEASALREE 440
P+ + SAP SL P P + ++TTP + +PP IQ S
Sbjct: 342 PLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPP--IQVPHSLTSPS 399
Query: 441 TEAWARPHESLAREEALTALG 461
+A P +L+ +A T+LG
Sbjct: 400 LQAPPSP-LALSSLQATTSLG 419
Score = 31.6 bits (70), Expect = 2.5
Identities = 31/106 (29%), Positives = 39/106 (36%), Gaps = 14/106 (13%)
Query: 331 GPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEG----RPPPLLPGGP 386
G P +L S SA +P + P PS P+G RPP + P
Sbjct: 233 GLQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR- 289
Query: 387 VCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD-----ITLVLPP 427
K AA A L P P+PS A + PD + LPP
Sbjct: 290 --KDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPP 333
Score = 31.2 bits (69), Expect = 3.2
Identities = 45/149 (30%), Positives = 55/149 (36%), Gaps = 35/149 (23%)
Query: 318 VQTLLGDPAPPLSGPMA--PCQSALESIQSARAAQAP----------HWKSLQQQDVTAV 365
+QT L PLS P+ P Q AL S+ S + QAP SL +
Sbjct: 469 LQTSLSPAVSPLSSPLTIHPLQ-ALSSLAS-HSPQAPLSSLIMPPLETQSSLAPPSLQTP 526
Query: 366 PMS----PSSHSPEGRPPPLLPGGPVCKAAASAPSS---LLDQPCLCPAPSVRTAVALTT 418
P S P + P PPPL ASAP + L PC P P LTT
Sbjct: 527 PASLTTPPLENLPSLAPPPL--------QTASAPLTTPHLETPPCPAPCPLQAPPSPLTT 578
Query: 419 PDITLVLPPDVIQQEASALREETEAWARP 447
P PP+ A+ + A A P
Sbjct: 579 P------PPETPSSIATPPPQAPPALASP 601
Score = 30.4 bits (67), Expect = 5.5
Identities = 29/117 (24%), Positives = 48/117 (41%), Gaps = 17/117 (14%)
Query: 326 APPLSGPMAPCQSALESIQSARAAQAPHWKSL---------QQQDVTAVPMSPSSHSPEG 376
+P L P +P AL S+Q+ + +P ++ Q Q P P+S P+
Sbjct: 397 SPSLQAPPSPL--ALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDS 454
Query: 377 RP---PPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDI---TLVLPP 427
P P LP P + + S S L P +++A +P +L++PP
Sbjct: 455 PPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPP 511
>gi|187937179 apoptosis-associated tyrosine kinase [Homo sapiens]
Length = 1374
Score = 40.4 bits (93), Expect = 0.005
Identities = 34/120 (28%), Positives = 45/120 (37%), Gaps = 25/120 (20%)
Query: 323 GDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSS----------- 371
G P PL+G + LE + + RAAQ HW+S + + P S
Sbjct: 652 GAPPLPLTG-----EDELEEVGARRAAQRGHWRSNVSANNNSGSRCPESWDPVSAGGHAE 706
Query: 372 ------HSPEGRPPPLLPGGPVC---KAAASAPSSLLDQPCLCPAPSVRTAVALTTPDIT 422
+P P P PG P+ A+A P P LC A + A L TP T
Sbjct: 707 GCPSPKQTPRASPEPGYPGEPLLGLQAASAQEPGCCPGLPHLCSAQGLAPAPCLVTPSWT 766
>gi|239754940 PREDICTED: hypothetical protein [Homo sapiens]
Length = 159
Score = 40.0 bits (92), Expect = 0.007
Identities = 35/108 (32%), Positives = 44/108 (40%), Gaps = 21/108 (19%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKS------------------LQQQDVTAVP 366
PAP + P AP + + SA AA P +S LQ + AVP
Sbjct: 50 PAPAAAHPPAPRERPAAARLSALAAAQPRRRSPGPQGGGGGDIASPLPPALQPRGAPAVP 109
Query: 367 MSPSSHSPEGRP---PPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVR 411
+PS RP PP P PV A +S P+ Q PAPS+R
Sbjct: 110 AAPSPGPLPARPSSPPPSPPSPPVPTAQSSLPAPWPPQGPRSPAPSLR 157
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 38.9 bits (89), Expect = 0.016
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 8/111 (7%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 379
P+PP+ P +P S S + +QAP + V + PMSPS+ P PP
Sbjct: 444 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 503
Query: 380 PL-LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 427
PL P + K AP +L P L P+ A +P +L + P
Sbjct: 504 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 554
Score = 30.8 bits (68), Expect = 4.2
Identities = 28/96 (29%), Positives = 37/96 (38%), Gaps = 13/96 (13%)
Query: 326 APPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGG 385
A P GP++ A S +A +QAP + A P S S P PL P
Sbjct: 292 AAPALGPLSSSPLATPSPSAALQSQAP-------PTLPATPHSSSLTCQLATPLPLAPPS 344
Query: 386 PVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDI 421
P SAP SL P P + +L +P +
Sbjct: 345 P------SAPPSLQTLPSPPATPPSQATTSLGSPTL 374
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 38.9 bits (89), Expect = 0.016
Identities = 33/111 (29%), Positives = 47/111 (42%), Gaps = 8/111 (7%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV-----TAVPMSPSSHSPEGRPP 379
P+PP+ P +P S S + +QAP + V + PMSPS+ P PP
Sbjct: 405 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 464
Query: 380 PL-LPGGPVCKAAASAPSSLLDQP--CLCPAPSVRTAVALTTPDITLVLPP 427
PL P + K AP +L P L P+ A +P +L + P
Sbjct: 465 PLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSP 515
Score = 30.4 bits (67), Expect = 5.5
Identities = 30/109 (27%), Positives = 40/109 (36%), Gaps = 9/109 (8%)
Query: 331 GPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEG----RPPPLLPGGP 386
G P +L S SA +P + P PS P+G RPP + P
Sbjct: 224 GLQRPASRSLSS--SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPR- 280
Query: 387 VCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEAS 435
K AA A L P P+PS + + TL PP +A+
Sbjct: 281 --KDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327
>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
sapiens]
Length = 1560
Score = 38.9 bits (89), Expect = 0.016
Identities = 44/174 (25%), Positives = 61/174 (35%), Gaps = 13/174 (7%)
Query: 324 DPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLP 383
+PAP GP P APH A SS P P
Sbjct: 849 NPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQL 908
Query: 384 GGPVCKAAASAPSS-----LLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQ---QEAS 435
P + +P+ L+ +P P P RT +TTP L P +++ Q S
Sbjct: 909 QFPPSQGPHKSPTPPPTLHLVPEPAAPPPPPPRTFQMVTTPFPALPQPKALLERFHQVPS 968
Query: 436 ALREETEAWARPHESLAREEALTALGKLLYLLDGML-DGQVNSGIAATPASAAA 488
+ + +A P A + T+LG L +L GQ SG P+ A A
Sbjct: 969 GIILQNKAGGAP----AAPQTSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPA 1018
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 38.5 bits (88), Expect = 0.020
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 10/114 (8%)
Query: 306 HLESLAESVCMTVQ---TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV 362
HL + E +C+ Q L GD AP S P ++A + SA + +P + +
Sbjct: 628 HLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK- 686
Query: 363 TAVPMSPSSHSPE-GRPPPL-----LPGGPVCKAAASAPSSLLDQPCLCPAPSV 410
A P S +PE +PPPL L G P KA + L +P PSV
Sbjct: 687 DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 38.5 bits (88), Expect = 0.020
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 10/114 (8%)
Query: 306 HLESLAESVCMTVQ---TLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDV 362
HL + E +C+ Q L GD AP S P ++A + SA + +P + +
Sbjct: 628 HLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSPKK- 686
Query: 363 TAVPMSPSSHSPE-GRPPPL-----LPGGPVCKAAASAPSSLLDQPCLCPAPSV 410
A P S +PE +PPPL L G P KA + L +P PSV
Sbjct: 687 DAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSV 740
>gi|116284392 mucin 2 precursor [Homo sapiens]
Length = 5179
Score = 36.6 bits (83), Expect = 0.077
Identities = 26/103 (25%), Positives = 39/103 (37%), Gaps = 4/103 (3%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPG 384
P+PP + P+ P S + + P + T P P++ +P PP +
Sbjct: 1539 PSPPTTTPITPPTSTTTLPPTTTPSPPP--TTTTTPPPTTTPSPPTTTTPS--PPTITTT 1594
Query: 385 GPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 427
P S P++ P PS T +T P T LPP
Sbjct: 1595 TPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPP 1637
Score = 32.3 bits (72), Expect = 1.5
Identities = 27/118 (22%), Positives = 39/118 (33%), Gaps = 8/118 (6%)
Query: 315 CMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSP 374
C + + P+PP + P P S + +P + T P SP +
Sbjct: 1389 CWPMDKCITTPSPPTTTPSPPPTST--TTLPPTTTPSPPTTTTTTPPPTTTP-SPPITTT 1445
Query: 375 EGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPA-----PSVRTAVALTTPDITLVLPP 427
PP P P+ P++ P P+ PS T T P T PP
Sbjct: 1446 TTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPP 1503
Score = 30.4 bits (67), Expect = 5.5
Identities = 24/108 (22%), Positives = 37/108 (34%), Gaps = 6/108 (5%)
Query: 325 PAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPE-----GRPP 379
P+PP + P+ P S + + P + T P + ++ SP PP
Sbjct: 1618 PSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPP 1677
Query: 380 PLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPP 427
P P+ S P++ + P PS T T PP
Sbjct: 1678 TTTPSSPIT-TTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPP 1724
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,911,044
Number of Sequences: 37866
Number of extensions: 1456516
Number of successful extensions: 6294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 5983
Number of HSP's gapped (non-prelim): 387
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.