Search of human proteins with 194097477

Search of human proteins with 194097477

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
         (802 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]            1632   0.0  
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]        110   4e-24
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]     106   1e-22
gi|21614542 single-minded homolog 1 [Homo sapiens]                     96   1e-19
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ...    96   1e-19
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ...    96   1e-19
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]               92   2e-18
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ...    90   7e-18
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [...    90   7e-18
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]            88   3e-17
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ...    87   8e-17
gi|4502003 aryl hydrocarbon receptor [Homo sapiens]                    86   1e-16
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]     78   4e-14
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]     70   8e-12
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]         59   1e-08
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...    59   2e-08
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...    59   2e-08
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...    59   2e-08
gi|222352122 hypothetical protein LOC284297 [Homo sapiens]             56   1e-07
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo...    55   3e-07
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor...    55   3e-07
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    54   6e-07
gi|4758010 clock [Homo sapiens]                                        54   8e-07
gi|163965366 nascent polypeptide-associated complex alpha subuni...    53   1e-06
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap...    50   6e-06
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap...    50   6e-06
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi...    50   6e-06
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...    50   8e-06
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo...    50   8e-06
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho...    50   1e-05

>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
          Length = 802

 Score = 1632 bits (4227), Expect = 0.0
 Identities = 802/802 (100%), Positives = 802/802 (100%)

Query: 1   MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60
           MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT
Sbjct: 1   MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60

Query: 61  PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY 120
           PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY
Sbjct: 61  PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY 120

Query: 121 DIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGA 180
           DIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGA
Sbjct: 121 DIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGA 180

Query: 181 YWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGF 240
           YWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGF
Sbjct: 181 YWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGF 240

Query: 241 ERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS 300
           ERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS
Sbjct: 241 ERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS 300

Query: 301 EGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTN 360
           EGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTN
Sbjct: 301 EGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTN 360

Query: 361 PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL 420
           PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL
Sbjct: 361 PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL 420

Query: 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP 480
           VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP
Sbjct: 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP 480

Query: 481 LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA 540
           LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA
Sbjct: 481 LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA 540

Query: 541 HLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV 600
           HLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV
Sbjct: 541 HLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV 600

Query: 601 DVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE 660
           DVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE
Sbjct: 601 DVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE 660

Query: 661 PLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTP 720
           PLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTP
Sbjct: 661 PLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTP 720

Query: 721 DPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDEL 780
           DPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDEL
Sbjct: 721 DPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDEL 780

Query: 781 HQLQSQVQDSFHEDGSGGEPTF 802
           HQLQSQVQDSFHEDGSGGEPTF
Sbjct: 781 HQLQSQVQDSFHEDGSGGEPTF 802


>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
          Length = 667

 Score =  110 bits (276), Expect = 4e-24
 Identities = 157/634 (24%), Positives = 251/634 (39%), Gaps = 96/634 (15%)

Query: 1   MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF---- 56
           M   +K A+K RR++ N E   L +LLPL  A   +L    I+ L   Y +    F    
Sbjct: 1   MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60

Query: 57  --AGGTPL-AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
             A G P  AGP   ++ +    ++  L GF+ V  ++GK++Y+SE+ S HLG S V+L 
Sbjct: 61  GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120

Query: 114 AQGDSIYDIIDPADH------LTVRQQL--TLPSALDTDRLFRCRFNTSKSLRRQS---A 162
             G+SIY+ I P+DH      LT  Q L   L    + +R F  R     + R      +
Sbjct: 121 --GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCS 178

Query: 163 GNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPAS---LFLAMFQS 219
           G K++   G         Y     ++ + C  +      G    P   +   L+  MF  
Sbjct: 179 GYKVIHCSGYLKIR---QYMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMF 234

Query: 220 RHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAE 279
           R + DL L+ +   V    G+E  +L+ K+ Y  +H  D+ H    H+ LL + G +  +
Sbjct: 235 RASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK-GQVTTK 293

Query: 280 MVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLR---QQLNSEDT 331
              RL +K GGW W+     ++++     P  I + NY ++++E   L+   +Q+++  +
Sbjct: 294 -YYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKS 352

Query: 332 QAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELP 391
           Q ++     T          SQE      P  T      R+  +P     S      E  
Sbjct: 353 QDSWRTALST----------SQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECG 402

Query: 392 RPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTP 451
           +          +  + PE    +E S DL+ TP Y        +  FS H     H P  
Sbjct: 403 QLGNWRASPPASAAAPPELQPHSE-SSDLLYTPSY--------SLPFSYH---YGHFPLD 450

Query: 452 SSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQ 511
           S             FS +     A F  P  SP +      S      +   C   + + 
Sbjct: 451 SH-----------VFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGE---CQWHYANP 496

Query: 512 LLPSTAT----FPEPLGSPAHEQLTPPSTAFQAHL-----DSPSQTFPE--------QLS 554
           L+PS+++     PEP  + A   L P   A  A +     D+   +FP          L 
Sbjct: 497 LVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYREEPALG 556

Query: 555 PNPTKTYFAQEGCSFLYEK------LPPSPSSPG 582
           P       A++G      +       PP+P +PG
Sbjct: 557 PAKAARQAARDGARLALARAAPECCAPPTPEAPG 590


>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
          Length = 570

 Score =  106 bits (264), Expect = 1e-22
 Identities = 143/566 (25%), Positives = 229/566 (40%), Gaps = 77/566 (13%)

Query: 1   MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF---- 56
           M   +K A+K RR++ N E   L +LLPL  A   +L    I+ L   Y +    F    
Sbjct: 1   MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60

Query: 57  --AGGTPL-AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
             A G P  AGP   ++ +    ++  L GF+ V  ++GK++Y+SE+ S HLG S V+L 
Sbjct: 61  GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120

Query: 114 AQGDSIYDIIDPADH------LTVRQQL--TLPSALDTDRLFRCRFNTSKSLRRQS---A 162
             G+SIY+ I P+DH      LT  Q L   L    + +R F  R     + R      +
Sbjct: 121 --GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCS 178

Query: 163 GNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPAS---LFLAMFQS 219
           G K++   G         Y     ++ + C  +      G    P   +   L+  MF  
Sbjct: 179 GYKVIHCSGYLKIR---QYMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMF 234

Query: 220 RHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAE 279
           R + DL L+ +   V    G+E  +L+ K+ Y  +H  D+ H    H+ LL + G +  +
Sbjct: 235 RASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK-GQVTTK 293

Query: 280 MVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLR---QQLNSEDT 331
              RL +K GGW W+     ++++     P  I + NY ++++E   L+   +Q+++  +
Sbjct: 294 -YYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKS 352

Query: 332 QAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELP 391
           Q ++     T          SQE      P  T      R+  +P     S      E  
Sbjct: 353 QDSWRTALST----------SQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECG 402

Query: 392 RPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTP 451
           +          +  + PE    +E S DL+ TP Y        +  FS H     H P  
Sbjct: 403 QLGNWRASPPASAAAPPELQPHSE-SSDLLYTPSY--------SLPFSYH---YGHFPLD 450

Query: 452 SSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQ 511
           S             FS +     A F  P  SP +      S      +   C   + + 
Sbjct: 451 SH-----------VFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGE---CQWHYANP 496

Query: 512 LLPSTAT----FPEPLGSPAHEQLTP 533
           L+PS+++     PEP  + A   L P
Sbjct: 497 LVPSSSSPAKNPPEPPANTARHSLVP 522


>gi|21614542 single-minded homolog 1 [Homo sapiens]
          Length = 766

 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 99/380 (26%), Positives = 154/380 (40%), Gaps = 44/380 (11%)

Query: 1   MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60
           M   +K A++ RR++ N+E   L +LLPL  A   +L    I+ L   Y +  V F  G 
Sbjct: 1   MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60

Query: 61  PLA-------GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
             A        P   +  +    ++  L GF+ V   +GK++Y+SE+ S HLG S V+L 
Sbjct: 61  GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120

Query: 114 AQGDSIYDIIDPADHLTVRQQLT--------LPSALDTDRLFRCRFNTSKSLRRQS---A 162
             G+SIY+ I PADH  +   LT             + +R F  R     + R       
Sbjct: 121 --GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCG 178

Query: 163 GNKLVLIRGRFHAHP--------PGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFL 214
           G K++   G               G Y   N    A    L P              L  
Sbjct: 179 GYKVIHCSGYLKIRQYSLDMSPFDGCY--QNVGLVAVGHSLPP-------SAVTEIKLHS 229

Query: 215 AMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESG 274
            MF  R + D+ L+ +   V    G+E  +L+ K+ Y  +H  D  H    H+ LL + G
Sbjct: 230 NMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVK-G 288

Query: 275 DIQAEMVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLRQQLNSE 329
            +  +   R  AK GGW W+     ++++     P  I + NY ++D E   L+  L+  
Sbjct: 289 QVTTK-YYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI 347

Query: 330 DTQAAYVLGTPTMLPSFPEN 349
                    T +  P+  +N
Sbjct: 348 SASKPAFSYTSSSTPTMTDN 367


>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
           [Homo sapiens]
          Length = 667

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 118/447 (26%), Positives = 181/447 (40%), Gaps = 45/447 (10%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGG--TPL 62
           ++ A+++RR Q    +  L   LP A      L    IM L   Y R     A G    +
Sbjct: 17  SRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQV 76

Query: 63  AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDI 122
                 L A  L+    AL GF++V TAEG + YLSE+VS+HLG S ++L+  G SI+D 
Sbjct: 77  GAGGEPLDACYLK----ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI--GHSIFDF 130

Query: 123 IDPADHLTVRQQLTLPSALD-------TDRLFRCRFNTS-----KSLRRQSAGNKLVLIR 170
           I P D   ++  LT    L        T+R F  R  ++     ++L  ++A  K++   
Sbjct: 131 IHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCS 190

Query: 171 GRFHAHPPGAYW--AGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALL 228
           G   A+ P A    AG+P        L       P PG     L    F SRH+ D+   
Sbjct: 191 GHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFT 250

Query: 229 DISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKT 288
              + +    G+   +L+  S Y  +H  D    S   + LL++   +  +   R  A++
Sbjct: 251 YCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ--YRFLARS 308

Query: 289 GGWAWIYC-LLYSEGPEGP----ITANNYPISDMEAWSLRQQLNSEDTQAAYVL--GTPT 341
           GG+ W         G  GP    I   ++ IS +E   +   L   +  +   +  G P 
Sbjct: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAP- 367

Query: 342 MLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSY 401
                     SQ++  + NP  +     PR  +F   P LS  + + + PR     D   
Sbjct: 368 ----------SQKD--TPNPGDSLDTPGPRILAFLHPPSLSEAALAAD-PRRFCSPDLRR 414

Query: 402 LTFPSGPEPSLQAELSKDLVCTPPYTP 428
           L  P     S+ A  S  L    P +P
Sbjct: 415 LLGPILDGASVAATPSTPLATRHPQSP 441


>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
           [Homo sapiens]
          Length = 669

 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 118/447 (26%), Positives = 181/447 (40%), Gaps = 45/447 (10%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGG--TPL 62
           ++ A+++RR Q    +  L   LP A      L    IM L   Y R     A G    +
Sbjct: 19  SRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQV 78

Query: 63  AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDI 122
                 L A  L+    AL GF++V TAEG + YLSE+VS+HLG S ++L+  G SI+D 
Sbjct: 79  GAGGEPLDACYLK----ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI--GHSIFDF 132

Query: 123 IDPADHLTVRQQLTLPSALD-------TDRLFRCRFNTS-----KSLRRQSAGNKLVLIR 170
           I P D   ++  LT    L        T+R F  R  ++     ++L  ++A  K++   
Sbjct: 133 IHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCS 192

Query: 171 GRFHAHPPGAYW--AGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALL 228
           G   A+ P A    AG+P        L       P PG     L    F SRH+ D+   
Sbjct: 193 GHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFT 252

Query: 229 DISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKT 288
              + +    G+   +L+  S Y  +H  D    S   + LL++   +  +   R  A++
Sbjct: 253 YCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ--YRFLARS 310

Query: 289 GGWAWIYC-LLYSEGPEGP----ITANNYPISDMEAWSLRQQLNSEDTQAAYVL--GTPT 341
           GG+ W         G  GP    I   ++ IS +E   +   L   +  +   +  G P 
Sbjct: 311 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAP- 369

Query: 342 MLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSY 401
                     SQ++  + NP  +     PR  +F   P LS  + + + PR     D   
Sbjct: 370 ----------SQKD--TPNPGDSLDTPGPRILAFLHPPSLSEAALAAD-PRRFCSPDLRR 416

Query: 402 LTFPSGPEPSLQAELSKDLVCTPPYTP 428
           L  P     S+ A  S  L    P +P
Sbjct: 417 LLGPILDGASVAATPSTPLATRHPQSP 443


>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
          Length = 590

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 97/350 (27%), Positives = 143/350 (40%), Gaps = 79/350 (22%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAG 64
           ++ A+++RR + N E   L +LLPL  A   +L    I+ L+  Y R   F A G P  G
Sbjct: 50  SRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWG 109

Query: 65  ------PTGL---------LSAQELED-----IVAALPGFLLVFTAEGKLLYLSESVSEH 104
                 P GL         L ++  E      I+ +L GF+     EGK LY+SE+VS +
Sbjct: 110 LRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIY 169

Query: 105 LGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTL--------------------------- 137
           LG S V++   G S++D I P DH  V +QL L                           
Sbjct: 170 LGLSQVEMT--GSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTP 227

Query: 138 ----------PSALDTDRLFRCRFN---TSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAG 184
                     PS+L  +R F  R     T + L  +++G K++ + GR  AH  G    G
Sbjct: 228 EIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALG 287

Query: 185 NPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSE 244
           +   T   APL   P  G             M   R +  L +L     V  ++    SE
Sbjct: 288 H---TLPPAPLAELPLHG------------HMIVFRLSLGLTILACESRVSDHMDLGPSE 332

Query: 245 LLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
           L+ +S Y  +H +D       H  LL + G +       LQ + GG+ W+
Sbjct: 333 LVGRSCYQFVHGQDATRIRQSHVDLL-DKGQVMTGYYRWLQ-RAGGFVWL 380


>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
           [Homo sapiens]
          Length = 735

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 32/309 (10%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR-KGVFFAGGTPLA 63
           ++ A+++RR + +     L   LPL       L    +M L   Y R + +  AG   + 
Sbjct: 22  SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIE 81

Query: 64  GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
                + AQ     + AL GF++V T +G ++Y+S++V++++G +  +L   G S++D  
Sbjct: 82  DD---MKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELT--GHSVFDFT 136

Query: 124 DPADHLTVRQQLTLPSAL-------DTDRLFRCRFNTS-----KSLRRQSAGNKLVLIRG 171
            P DH  +R+ LT  + L       +T R F  R   +     +++  +SA  K++   G
Sbjct: 137 HPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTG 196

Query: 172 RFHAH------PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDL 225
             H +      P   Y    P  T      EP P P     P  +  FL    SRH+ D+
Sbjct: 197 HIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFL----SRHSLDM 250

Query: 226 ALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQ 285
                 E +   +G+E  ELL +S Y   H  D  H +  H+ +  +      +   R+ 
Sbjct: 251 KFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQ--YRML 308

Query: 286 AKTGGWAWI 294
           AK GG+ W+
Sbjct: 309 AKRGGYVWV 317


>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
           [Homo sapiens]
          Length = 826

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 32/309 (10%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR-KGVFFAGGTPLA 63
           ++ A+++RR + +     L   LPL       L    +M L   Y R + +  AG   + 
Sbjct: 22  SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIE 81

Query: 64  GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
                + AQ     + AL GF++V T +G ++Y+S++V++++G +  +L   G S++D  
Sbjct: 82  DD---MKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELT--GHSVFDFT 136

Query: 124 DPADHLTVRQQLTLPSAL-------DTDRLFRCRFNTS-----KSLRRQSAGNKLVLIRG 171
            P DH  +R+ LT  + L       +T R F  R   +     +++  +SA  K++   G
Sbjct: 137 HPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTG 196

Query: 172 RFHAH------PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDL 225
             H +      P   Y    P  T      EP P P     P  +  FL    SRH+ D+
Sbjct: 197 HIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFL----SRHSLDM 250

Query: 226 ALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQ 285
                 E +   +G+E  ELL +S Y   H  D  H +  H+ +  +      +   R+ 
Sbjct: 251 KFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQ--YRML 308

Query: 286 AKTGGWAWI 294
           AK GG+ W+
Sbjct: 309 AKRGGYVWV 317


>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
          Length = 870

 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 84/339 (24%), Positives = 150/339 (44%), Gaps = 34/339 (10%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAG 64
           ++ A++ RR +       L   LPL  +    L    IM LA  + R     +       
Sbjct: 19  SRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS-EN 77

Query: 65  PTGLLSAQELEDI-VAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
            +   + Q+++++ + AL GF+ V T +G +++LSE++S+ +G + V+L   G SI+D  
Sbjct: 78  ESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELT--GHSIFDFT 135

Query: 124 DPADHLTVRQQLTLPSA---------LDTDRLFRCRF-----NTSKSLRRQSAGNKLVLI 169
            P DH  +R+ L+L +          + T+R F  R      N  +++  +SA  K++  
Sbjct: 136 HPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHC 195

Query: 170 RGRFHAH---PPGAYWAG--NPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKD 224
            G+   +   PP     G   P+ +      EP   P     P  +  FL    SRH+ D
Sbjct: 196 TGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL----SRHSMD 251

Query: 225 LALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRL 284
           +      + +   +G+   ELL +S Y   H  D  + +  H  L  +   +  +   R+
Sbjct: 252 MKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQ--YRM 309

Query: 285 QAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDME 318
            AK GG+ W+     ++Y+     P  I   NY +S++E
Sbjct: 310 LAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIE 348


>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
           [Homo sapiens]
          Length = 613

 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 109/416 (26%), Positives = 169/416 (40%), Gaps = 51/416 (12%)

Query: 34  KVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGK 93
           ++ +SYL +  L C         AGG PL               + AL GF++V TAEG 
Sbjct: 2   RLTISYLRMHRL-CAAGEWNQVGAGGEPLDAC-----------YLKALEGFVMVLTAEGD 49

Query: 94  LLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALD-------TDRL 146
           + YLSE+VS+HLG S ++L+  G SI+D I P D   ++  LT    L        T+R 
Sbjct: 50  MAYLSENVSKHLGLSQLELI--GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERC 107

Query: 147 FRCRFNTS-----KSLRRQSAGNKLVLIRGRFHAHPPGAYW--AGNPVFTAFCAPLEPRP 199
           F  R  ++     ++L  ++A  K++   G   A+ P A    AG+P        L    
Sbjct: 108 FSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLIC 167

Query: 200 RPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDL 259
              P PG     L    F SRH+ D+      + +    G+   +L+  S Y  +H  D 
Sbjct: 168 EAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDS 227

Query: 260 AHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYC-LLYSEGPEGP----ITANNYPI 314
              S   + LL++   +  +   R  A++GG+ W         G  GP    I   ++ I
Sbjct: 228 DAVSKSIHTLLSKGQAVTGQ--YRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLI 285

Query: 315 SDMEAWSLRQQLNSEDTQAAYVL--GTPTMLPSFPENILSQEECSSTNPLFTAALGAPRS 372
           S +E   +   L   +  +   +  G P           SQ++  + NP  +     PR 
Sbjct: 286 SQVEETGVVLSLEQTEQHSRRPIQRGAP-----------SQKD--TPNPGDSLDTPGPRI 332

Query: 373 TSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
            +F   P LS  + + + PR     D   L  P     S+ A  S  L    P +P
Sbjct: 333 LAFLHPPSLSEAALAAD-PRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSP 387


>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
          Length = 848

 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 93/393 (23%), Positives = 152/393 (38%), Gaps = 82/393 (20%)

Query: 9   SKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFA----------- 57
           SK  RD++N E+  L  LLP  +    +L  L ++ L+  Y R   FF            
Sbjct: 36  SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERN 95

Query: 58  GGTPLAGPTGL---LSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVA 114
           GG            L+ QE E ++ AL GF+LV T +  + Y S ++ ++LG    D++ 
Sbjct: 96  GGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIH 155

Query: 115 QGDSIYDIIDPADHLTVRQQL--------------------TLPSAL---DTDRL----- 146
           Q  S+Y++I   D    ++QL                     LP  +   + D++     
Sbjct: 156 Q--SVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENS 213

Query: 147 ----------FRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLE 196
                      RC  + S      +   KL  + G+      G+         A   PL+
Sbjct: 214 PLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQ 273

Query: 197 PRPRPGPGPGPGPASLFLA----MFQSRHAKDLALLDISESVLIYLGFERSELLCK-SWY 251
           P           P+ L +     +F+++H  D   +       I LG+  +EL  + S Y
Sbjct: 274 P-----------PSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGY 322

Query: 252 GLLHPEDLAHASAQHYRLL--AESGDIQAEMVVRLQAKTGGWAWIYC---LLYSEGPEGP 306
             +H  D+ + +  H R++   ESG I    V RL  K   W W+     LLY  G    
Sbjct: 323 QFIHAADMLYCAESHIRMIKTGESGMI----VFRLLTKNNRWTWVQSNARLLYKNGRPDY 378

Query: 307 ITANNYPISDMEAWSLRQQLNSEDTQAAYVLGT 339
           I     P++D E     + L   +T+  ++  T
Sbjct: 379 IIVTQRPLTDEEG---TEHLRKRNTKLPFMFTT 408


>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
          Length = 901

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 107/465 (23%), Positives = 164/465 (35%), Gaps = 94/465 (20%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTP--- 61
           ++ A+++RR + N E   L +LLPL  A   +L    I+ L   Y +   F   G P   
Sbjct: 26  SRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWN 85

Query: 62  --LAGP---TGLLSAQELED----------------IVAALPGFLLVFTAEGKLLYLSES 100
             + GP   T +  AQ                    I+ +L GF+     EGK LY+SE+
Sbjct: 86  LRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISET 145

Query: 101 VSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL------------------------- 135
           VS +LG S V+L   G S++D + P DH+ + +QL                         
Sbjct: 146 VSIYLGLSQVELT--GSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASS 203

Query: 136 ------------TLPSALDTD----RLFRCRFN---TSKSLRRQSAGNKLVLIRGRFHAH 176
                       T PS L TD    R F  R     T + +  +S+G K++ I GR    
Sbjct: 204 SSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLR 263

Query: 177 PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLI 236
              ++    P   +    L       P P      +   MF +R   DL ++     +  
Sbjct: 264 VSLSHGRTVP---SQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISD 320

Query: 237 YLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI-- 294
           Y+     +++ K  Y  +H ED+      H  LL +   +      R   K GG+ WI  
Sbjct: 321 YMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV--TKYYRWMQKNGGYIWIQS 378

Query: 295 ---YCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENIL 351
                +      E  I   NY +S+ E       +                LP  PE   
Sbjct: 379 SATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDI--------------AQLPHLPEKTS 424

Query: 352 SQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKE 396
              E S +        G         + E    S + E P P ++
Sbjct: 425 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRK 469


>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
          Length = 920

 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 105/484 (21%), Positives = 164/484 (33%), Gaps = 113/484 (23%)

Query: 5   TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTP--- 61
           ++ A+++RR + N E   L +LLPL  A   +L    I+ L   Y +   F   G P   
Sbjct: 26  SRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWN 85

Query: 62  --LAGPTGLLSAQELE--------------------------------------DIVAAL 81
             + GP    S + ++                                       I+ +L
Sbjct: 86  LRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSL 145

Query: 82  PGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL------ 135
            GF+     EGK LY+SE+VS +LG S V+L   G S++D + P DH+ + +QL      
Sbjct: 146 DGFVFALNQEGKFLYISETVSIYLGLSQVELT--GSSVFDYVHPGDHVEMAEQLGMKLPP 203

Query: 136 -------------------------------TLPSALDTD----RLFRCRFN---TSKSL 157
                                          T PS L TD    R F  R     T + +
Sbjct: 204 GRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGV 263

Query: 158 RRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMF 217
             +S+G K++ I GR       ++    P   +    L       P P      +   MF
Sbjct: 264 HIKSSGYKVIHITGRLRLRVSLSHGRTVP---SQIMGLVVVAHALPPPTINEVRIDCHMF 320

Query: 218 QSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQ 277
            +R   DL ++     +  Y+     +++ K  Y  +H ED+      H  LL +   + 
Sbjct: 321 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV- 379

Query: 278 AEMVVRLQAKTGGWAWI-----YCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQ 332
                R   K GG+ WI       +      E  I   NY +S+ E       +      
Sbjct: 380 -TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDI------ 432

Query: 333 AAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPR 392
                     LP  PE      E S +        G         + E    S + E P 
Sbjct: 433 --------AQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPE 484

Query: 393 PSKE 396
           P ++
Sbjct: 485 PDRK 488


>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
          Length = 719

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 16/141 (11%)

Query: 9   SKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF-----------A 57
           SK  RD++NAE+ +L  LLP       +L  L ++ L+  Y R   FF           A
Sbjct: 37  SKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPA 96

Query: 58  GGTPLAGPTGLLSAQELED---IVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVA 114
            G P  G +  L+   + +   ++ +L GF LV +AEG + Y S ++ ++LG    D++ 
Sbjct: 97  AGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMH 156

Query: 115 QGDSIYDIIDPADHLTVRQQL 135
           Q  +IYD I   D     +QL
Sbjct: 157 Q--NIYDYIHVDDRQDFCRQL 175


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 7/141 (4%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIY--TRKGVFFAGGTPLAGPTG 67
           K RRD++N+ I  L  L+P   A   +L  L ++ +A  +  T +G           PT 
Sbjct: 39  KRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPT- 97

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            LS  EL+ ++  A  GFL V   + GK+L++SESV + L +S  DL+  G S++D + P
Sbjct: 98  FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI--GQSLFDYLHP 155

Query: 126 ADHLTVRQQLTLPSALDTDRL 146
            D   V++QL+       +RL
Sbjct: 156 KDIAKVKEQLSSSDTAPRERL 176



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)

Query: 227 LLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQA 286
           +L +SESV   L + +++L+ +S +  LHP+D+A    Q    L+ S     E ++   A
Sbjct: 126 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLI--DA 179

Query: 287 KTG 289
           KTG
Sbjct: 180 KTG 182


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 7/141 (4%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIY--TRKGVFFAGGTPLAGPTG 67
           K RRD++N+ I  L  L+P   A   +L  L ++ +A  +  T +G           PT 
Sbjct: 82  KRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPT- 140

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            LS  EL+ ++  A  GFL V   + GK+L++SESV + L +S  DL+  G S++D + P
Sbjct: 141 FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI--GQSLFDYLHP 198

Query: 126 ADHLTVRQQLTLPSALDTDRL 146
            D   V++QL+       +RL
Sbjct: 199 KDIAKVKEQLSSSDTAPRERL 219



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)

Query: 227 LLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQA 286
           +L +SESV   L + +++L+ +S +  LHP+D+A    Q    L+ S     E ++   A
Sbjct: 169 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLI--DA 222

Query: 287 KTG 289
           KTG
Sbjct: 223 KTG 225


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 7/141 (4%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIY--TRKGVFFAGGTPLAGPTG 67
           K RRD++N+ I  L  L+P   A   +L  L ++ +A  +  T +G           PT 
Sbjct: 82  KRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPT- 140

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            LS  EL+ ++  A  GFL V   + GK+L++SESV + L +S  DL+  G S++D + P
Sbjct: 141 FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI--GQSLFDYLHP 198

Query: 126 ADHLTVRQQLTLPSALDTDRL 146
            D   V++QL+       +RL
Sbjct: 199 KDIAKVKEQLSSSDTAPRERL 219



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)

Query: 227 LLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQA 286
           +L +SESV   L + +++L+ +S +  LHP+D+A    Q    L+ S     E ++   A
Sbjct: 169 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLI--DA 222

Query: 287 KTG 289
           KTG
Sbjct: 223 KTG 225


>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
          Length = 1573

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 91/432 (21%), Positives = 150/432 (34%), Gaps = 68/432 (15%)

Query: 339  TPTMLPSFPENILSQ----EECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPS 394
            +PT LP+ P+ + S      E +S +P       +  +    + P  S VS     P PS
Sbjct: 1087 SPTPLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPS 1146

Query: 395  KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSST 454
                 +     + P+P++  +    L   P  TPH P           P  T  P P++ 
Sbjct: 1147 PSPHPT-----TTPDPTMAPDPITTL--NPTVTPHFPT---------TPHPTTTPHPTTI 1190

Query: 455  LQEQLTPSTATFSDQLTP--SSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQL 512
                + P   T     T    S   PDP T+P      + +   +     P T+  P  +
Sbjct: 1191 THSTMIPDPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTPHPTTI 1250

Query: 513  LPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYE 572
              ST   P+P  +P       P+T     +  P+ T     +P+PT T       +  + 
Sbjct: 1251 THSTM-IPDPTTTPQPFTTMQPTT-----MPHPTTTPHPTTTPHPTTT---PHPTTTPHP 1301

Query: 573  KLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEI 632
             + P P++      T         P +   P  P+   TP  + V       +E     +
Sbjct: 1302 TMTPDPTTTPYPTTT-------PDPTTTPHPTTPDPSSTPVITTVSLPTSLGTELSSPTL 1354

Query: 633  DRLIQQI--SQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWK 690
               ++     QL      P ++ +    LEP   LE   S  S + +  P+ + D KP +
Sbjct: 1355 APTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPR 1414

Query: 691  CQE--------------LDFLADPDNMF------LEETPVEDIFMDLSTPDPSEEWGSGD 730
             Q                D    PD +       L+  P++ + +    P P +      
Sbjct: 1415 SQSPNLTPPPTHTPHSASDLTVSPDPLLSPTAHPLDHPPLDPLTLG---PTPGQ-----S 1466

Query: 731  PEAEGPGGAPSP 742
            P   GP  AP+P
Sbjct: 1467 PGPHGPCVAPTP 1478



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 61/225 (27%), Positives = 99/225 (44%), Gaps = 29/225 (12%)

Query: 370  PRSTSFPSAPELSVVSASEELPRP---SKELDFSYLTFPSGPEPSLQAELSKDLVCTPP- 425
            P ++  P  P L+  S+ E  P     S+    +  T P  P+P+  +  + DL+ T P 
Sbjct: 1011 PSASPGPPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPDPA--SRTNPDLILTSPD 1068

Query: 426  YTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLT--PSTATFSDQLTPSSA------TF 477
            +    P          EP     PTP  TL ++LT  PST +    L+P+S       T 
Sbjct: 1069 FALSTPDSSVVPALTPEPS----PTPLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTT 1124

Query: 478  PDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTP--PS 535
            PD  T+P    ++E S RS +   +P  +T PD   P+ A  P+P+ +  +  +TP  P+
Sbjct: 1125 PDLDTTPYSSTVSEYS-RSPDPSPSPHPTTTPD---PTMA--PDPI-TTLNPTVTPHFPT 1177

Query: 536  TAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSS 580
            T        P+      + P+PT T   Q   +  +  + P P++
Sbjct: 1178 TPHPTTTPHPTTITHSTMIPDPTTT--PQPFTTITHSTMIPDPTT 1220


>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
           3 [Homo sapiens]
          Length = 774

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 77/346 (22%), Positives = 134/346 (38%), Gaps = 66/346 (19%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
           + RR+++ A I  L +++P   A   +   L I+ +A  +  K +   G T   G     
Sbjct: 84  RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 142

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            L+ QEL+ ++  A  GFL + + E G+++Y+S+SV+  L     +    G ++YD + P
Sbjct: 143 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 200

Query: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAG---------------------- 163
            D   +R+QL+      T R+   +  T K   +QS+                       
Sbjct: 201 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVD 260

Query: 164 ----NKLVLIRGRFHAHPPGAYWAGNPVF-----TAFCAPLEPR----PRPGPGPGPGPA 210
               N+L  +R R   +  G+   G P F     T +     P     P   P  G G  
Sbjct: 261 PVSVNRLSFVRNRCR-NGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK 319

Query: 211 SLFLAM----------------------FQSRHAKDLALLDISESVLIYLGFERSELLCK 248
              +A+                      F SRH  +     +    +  +G++  ELL K
Sbjct: 320 FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGK 379

Query: 249 SWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
           +     HPED         +++   G + + M  R ++K   W W+
Sbjct: 380 NIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM-FRFRSKNQEWLWM 424


>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
           [Homo sapiens]
          Length = 789

 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 77/346 (22%), Positives = 134/346 (38%), Gaps = 66/346 (19%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
           + RR+++ A I  L +++P   A   +   L I+ +A  +  K +   G T   G     
Sbjct: 99  RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 157

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            L+ QEL+ ++  A  GFL + + E G+++Y+S+SV+  L     +    G ++YD + P
Sbjct: 158 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 215

Query: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAG---------------------- 163
            D   +R+QL+      T R+   +  T K   +QS+                       
Sbjct: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVD 275

Query: 164 ----NKLVLIRGRFHAHPPGAYWAGNPVF-----TAFCAPLEPR----PRPGPGPGPGPA 210
               N+L  +R R   +  G+   G P F     T +     P     P   P  G G  
Sbjct: 276 PVSVNRLSFVRNRCR-NGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK 334

Query: 211 SLFLAM----------------------FQSRHAKDLALLDISESVLIYLGFERSELLCK 248
              +A+                      F SRH  +     +    +  +G++  ELL K
Sbjct: 335 FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGK 394

Query: 249 SWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
           +     HPED         +++   G + + M  R ++K   W W+
Sbjct: 395 NIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM-FRFRSKNQEWLWM 439


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 87/330 (26%), Positives = 115/330 (34%), Gaps = 60/330 (18%)

Query: 343 LPSFPENILSQEECSSTNPLFTA--------------ALGAPRSTSFPSAPELSVVSASE 388
           LPS P    SQ   S T P   A              +L +P   + PS   LS + A+ 
Sbjct: 357 LPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATT 416

Query: 389 ELPRPSKELDFSYLTF-----------PSGP------EPSLQAELSKDLVCTPPYTPHQP 431
            L  P+ +   S+LT            PS P       P LQA LS      P   P Q 
Sbjct: 417 SLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLS-----LPASPPLQT 471

Query: 432 GGCAFLFSLHEPFQTH---------LPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLT 482
                +  L  P   H           +P + L   + P   T S    PS  T P  LT
Sbjct: 472 SLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLT 531

Query: 483 S-PLQG---------QLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLT 532
           + PL+          Q     + +   +  PC +  P Q  PS  T P P         T
Sbjct: 532 TPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPP--ETPSSIAT 589

Query: 533 PPSTAFQAHLDSPSQTFPE-QLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLAL 591
           PP  A  A    P Q  P   LSP  T    A    +    + PPSP  P +   + LA 
Sbjct: 590 PPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSP--PASPPLSPLAT 647

Query: 592 AQLRGPLSVDVPLVPEGLLTPEASPVKQSF 621
              + P ++ V L+      P + PV+  F
Sbjct: 648 PSPQAPNALAVHLLQAPFSPPPSPPVQAPF 677



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 76/291 (26%), Positives = 100/291 (34%), Gaps = 35/291 (12%)

Query: 338 GTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFP-----SAPELSVVSASEELPR 392
           GTP   P+ P    SQ +      L    +  PR  + P     S+  L+  S S    R
Sbjct: 261 GTPRA-PAHP----SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKAR 315

Query: 393 PSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPS 452
           P    D +    P+   PS    L+  L   PP +P  P           P    LP+P 
Sbjct: 316 PVPPPDNAATPLPATLPPS--PPLATPLPLAPP-SPSAP-----------PSLQTLPSPP 361

Query: 453 STLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLT----PCTSTF 508
           +T   Q  PS  T   Q  PS  T P P+  P    LT  S+++    L       T++ 
Sbjct: 362 ATPPSQAPPSMTTPPMQAPPSLQTIP-PIQVP--HSLTSPSLQAPPSPLALSSLQATTSL 418

Query: 509 PDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCS 568
               L +T +F           LT PS       DSP    P  L  +P          S
Sbjct: 419 GSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVS 478

Query: 569 FLYEKLPPSP----SSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEAS 615
            L   L   P    SS  +        + +  PL     L P  L TP AS
Sbjct: 479 PLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 529



 Score = 38.9 bits (89), Expect = 0.019
 Identities = 68/266 (25%), Positives = 90/266 (33%), Gaps = 32/266 (12%)

Query: 361 PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL 420
           P    AL +P     PS P LS ++     P P      +     + P P     LS   
Sbjct: 592 PQAPPALASPPLQGLPSPP-LSPLAT----PPPQAPPXLALPPLQAPPSPPASPPLSP-- 644

Query: 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTP-STATFSDQLTPSSATFPD 479
           + TP  +P  P   A +  L  PF    P PS  +Q   +P ++   S   TP S   P 
Sbjct: 645 LATP--SPQAPNALA-VHLLQAPFS---PPPSPPVQAPFSPPASPPVSPSATPPSQAPPS 698

Query: 480 PLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQ 539
               PLQ   +  +        TP     P    P     P P  SP       P     
Sbjct: 699 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVP 758

Query: 540 AHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLAL-------- 591
             L +P    P Q+ P+P     A    S L +  PP  + P      L AL        
Sbjct: 759 PLLAAP----PLQVPPSPP----ASLPMSPLAK--PPPQAPPALATPPLQALPSPPASFP 808

Query: 592 AQLRGPLSVDVPLVPEGLLTPEASPV 617
            Q     S  +P+ P     P+A PV
Sbjct: 809 GQAPFSPSASLPMSPLATPPPQAPPV 834



 Score = 33.1 bits (74), Expect = 1.0
 Identities = 44/168 (26%), Positives = 57/168 (33%), Gaps = 10/168 (5%)

Query: 369 APRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
           +P +T  P  P L      +  P P   L  S L  P    P   A      + +PP + 
Sbjct: 748 SPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPAS- 806

Query: 429 HQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPS---SATFPDPLTSPL 485
             PG   F  S   P      +P +T   Q  P  A    Q+ PS   S T   P   P 
Sbjct: 807 -FPGQAPFSPSASLPM-----SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 860

Query: 486 QGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTP 533
            G  T  S       L P     P +   ST + P+  G  +    TP
Sbjct: 861 PGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 908


>gi|4758010 clock [Homo sapiens]
          Length = 846

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 122/538 (22%), Positives = 191/538 (35%), Gaps = 115/538 (21%)

Query: 4   STKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLA 63
           S   + K RRDQ N  I+ L  +LP   A K+  S +   S+  +   K +         
Sbjct: 38  SRNKSEKKRRDQFNVLIKELGSMLP-GNARKMDKSTVLQKSIDFLRKHKEITAQSDASEI 96

Query: 64  G----PTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSI 119
                PT L + +  + ++ AL GF L    +G ++Y+SESV+  L H   DLV Q  SI
Sbjct: 97  RQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQ--SI 154

Query: 120 YDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLV----LIRGRFHA 175
           ++ I   +H  V + L+    L++D L      T + L+ +   N+L     ++RG    
Sbjct: 155 FNFIPEGEHSEVYKILS-THLLESDSL------TPEYLKSK---NQLEFCCHMLRGTIDP 204

Query: 176 HPPGAY----WAGN---------PVFTAFCAPLEPRPRPG-PGPGPGPASLFLAM----- 216
             P  Y    + GN              F   ++   RP         A++ LA      
Sbjct: 205 KEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIK 264

Query: 217 -----------FQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQ 265
                      F SRH+ +   L +       +G+   E+L  S Y   H +DL + +  
Sbjct: 265 EMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKC 324

Query: 266 HYRLLAESGDIQAEMVVRLQAKTGGWAWI---YCLLYSEGPEGP--ITANNYPISDMEAW 320
           H  L+            R   K   W W+   Y + Y +    P  I   +  +S  E  
Sbjct: 325 HEHLMQYGKG--KSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVR 382

Query: 321 SLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPE 380
           + R++           LG    LP                        A +S    S   
Sbjct: 383 AERRR----------ELGIEESLPE---------------------TAADKSQDSGSDNR 411

Query: 381 LSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSK----DLVCTPPYTPHQPGGCAF 436
           ++ VS  E L R           F   P PS  +  S+      V  P  TP +      
Sbjct: 412 INTVSLKEALER-----------FDHSPTPSASSRSSRKSSHTAVSDPSSTPTK-----I 455

Query: 437 LFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSV 494
                 P + HLP     +Q + + S+ + + Q   SS      LT P+  Q T   +
Sbjct: 456 PTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSS------LTQPVMSQATNLPI 507


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 70/278 (25%), Positives = 107/278 (38%), Gaps = 50/278 (17%)

Query: 361  PLFTAALGAPRSTSFPSAPELSVVS--ASEELPRPSK-ELDFSYLTFPSGPEPSLQAELS 417
            P  +A  G P + S    P L  V+  + +E P P +     S    P+ P P     L 
Sbjct: 1447 PATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLP 1506

Query: 418  KDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATF 477
              +  +P   P  P       S  +P       P++TL  + TP+T    + L P + T 
Sbjct: 1507 AVIPSSPKEVPATPS------SRRDPI-----APTATLLSKKTPATLAPKEALIPPAMTV 1555

Query: 478  PDP-----LTSPLQGQLTETSVR-SYEDQLTPCT---STFPDQLL-PSTATFPEPLGSPA 527
            P P     + +P +   T +S   S    +TP T   +  P +LL P   T P P  +P 
Sbjct: 1556 PSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPT 1615

Query: 528  HEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCT 587
               +TPPS         P+   P+    +P  T             L  SP+SP +  C 
Sbjct: 1616 PPAVTPPSPE-----KGPATPAPKGTPTSPPVT----------PSSLKDSPTSPASVTCK 1660

Query: 588  LLA--------LAQLRGPLSVDVPLVPEGLLTPEASPV 617
            + A        L   +GP ++   LV      PE++P+
Sbjct: 1661 MGATVPQASKGLPAKKGPTALKEVLVAP---APESTPI 1695



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 67/264 (25%), Positives = 88/264 (33%), Gaps = 19/264 (7%)

Query: 357  SSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAE 415
            ++T P     L  P     P+ P  +  S    L  PS K    +    P  P+  L   
Sbjct: 1176 AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1235

Query: 416  LSKDLVCTPPYTPHQP-GGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSS 474
              K    TP  TP  P GG A       P     PTP +     L    AT   +  P+ 
Sbjct: 1236 SPKGAPTTPAATPPSPKGGPA------TPPPKGAPTPPAATPPSLKGGLATPPHKGAPNP 1289

Query: 475  ATFPDP------LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAH 528
            A    P       TSP +G  T  +      + +P T        P   T P P G+P  
Sbjct: 1290 AVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTL 1349

Query: 529  EQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTL 588
               TP S        S     P    P  T ++      +    K  P+  SP  GD T 
Sbjct: 1350 PATTPSSKGGPTTPSSKEGPTP----PAATPSHKGGPAMTPPSPKRGPAIPSP-KGDPTS 1404

Query: 589  LALAQLRGPLSVDVPLVPEGLLTP 612
             A+  L    +   P+  EG  TP
Sbjct: 1405 PAVIPLSPKKAPATPVTREGAATP 1428



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 83/327 (25%), Positives = 114/327 (34%), Gaps = 71/327 (21%)

Query: 300  SEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSST 359
            S GP+ PI   + P+S +EA  L +  NS   Q +      T  P+ P +       S+ 
Sbjct: 814  SAGPDTPIGNLSSPVSPVEASFLPE--NSLSFQGSKDSPATTHSPT-PPSPKGAPTPSAV 870

Query: 360  NPLFTAALGAP-RSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSK 418
             PL    +  P + T  PS   L         P P +    S  +  S P+ +      K
Sbjct: 871  TPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTS--SSPKKARATPAPK 928

Query: 419  DLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQL--TPSSAT 476
             +  +P      P G               PTP +          AT S +   TP +AT
Sbjct: 929  GIPASP-----SPKGA--------------PTPPAATPPSPKGGPATPSPKWAPTPPAAT 969

Query: 477  FPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLL-PSTATFPEPLGSPAHEQLTPPS 535
             P P   P        +  S +   TP  +T P     P+T   P P G+P    +TPPS
Sbjct: 970  PPSPKGGP--------ATPSPKGAPTPPAATPPSPKGGPAT---PSPKGAPTPPAVTPPS 1018

Query: 536  TAFQAHLDSPSQT-FPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQL 594
                    SP+ T FP+  S  P  T              PPSP   G+   T       
Sbjct: 1019 PK-----GSPAATPFPKGASTPPAAT--------------PPSPK--GSPAAT------- 1050

Query: 595  RGPLSVDVPLVPEGLL-TPEASPVKQS 620
              PL    P  P   L +P+  P   S
Sbjct: 1051 --PLPKGAPTTPAATLPSPKGGPATPS 1075



 Score = 37.7 bits (86), Expect = 0.043
 Identities = 46/178 (25%), Positives = 68/178 (38%), Gaps = 17/178 (9%)

Query: 405  PSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTA 464
            P  P+ S      K     P  TP  P G   L +     +    TPSS  +E  TP  A
Sbjct: 1317 PPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSS--KEGPTPPAA 1374

Query: 465  TFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYE-DQLTPCTSTFPDQLLPSTATFPEPL 523
            T S +  P+  T P P   P        ++ S + D  +P       +  P+T    E  
Sbjct: 1375 TPSHKGGPAM-TPPSPKRGP--------AIPSPKGDPTSPAVIPLSPKKAPATPVTREGA 1425

Query: 524  GSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSP 581
             +P+   LTPP+    +   +P+ + P+     P     + +G   L    PPSP  P
Sbjct: 1426 ATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATP-----SSKGDPTLPAVTPPSPKEP 1478



 Score = 33.5 bits (75), Expect = 0.80
 Identities = 50/193 (25%), Positives = 60/193 (31%), Gaps = 22/193 (11%)

Query: 405  PSGPEPSLQAELSKDLVCTPPYTPHQP-GGCAFLFSLHEPFQTHLPTPSSTLQEQLTPST 463
            P  P+        K     P  TP  P GG A       P    +  PS       TP  
Sbjct: 970  PPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFP 1029

Query: 464  ATFSDQLTPSSATFPDPLTSPL-----QGQLTETSVRSYEDQLTPCTSTFPDQLLPSTAT 518
               S   TP +AT P P  SP      +G  T  +      +  P T +      P  AT
Sbjct: 1030 KGAS---TPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT 1086

Query: 519  FPEPLGSPAHEQ---------LTPPS----TAFQAHLDSPSQTFPEQLSPNPTKTYFAQE 565
             P P G PA             TPPS     A   H  +P+       SP         +
Sbjct: 1087 PPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPK 1146

Query: 566  GCSFLYEKLPPSP 578
            G        PPSP
Sbjct: 1147 GAPTTPAATPPSP 1159


>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 78/380 (20%), Positives = 138/380 (36%), Gaps = 68/380 (17%)

Query: 370 PRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
           P+    P APE ++ S  E+LP+ S K +       P      +Q +L        P   
Sbjct: 47  PKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-----NIPKAS 101

Query: 429 HQPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQ- 486
            +P          +P +  +P  P  T+Q +      +  + + P     P     P+Q 
Sbjct: 102 VKPS---------QPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 152

Query: 487 --GQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQL--TPPSTAFQAHL 542
             G + +TSV+  + + +    +  + + P     P+    P   +L   P ++      
Sbjct: 153 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV----- 207

Query: 543 DSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDV 602
             PSQ     +S +P +    +EG       LP S             L +   P   D+
Sbjct: 208 -KPSQPKEGDISKSPEEAIQPKEG------DLPKS-------------LEEAIQPKEGDI 247

Query: 603 PLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE-- 660
           P  PE  + P+   + +S     + ++ +I +  ++  Q  +G D P S E      E  
Sbjct: 248 PKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGD 306

Query: 661 ----PLGGLEPLDSNL--SLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIF 714
               P   ++P + ++  SL  A PP           +E+D    P+     +   +D  
Sbjct: 307 IPKSPKQAIQPKEGDIPKSLEEAIPP-----------KEIDIPKSPEETI--QPKEDDSP 353

Query: 715 MDLSTPDPSEEWGSGDPEAE 734
             L    PS+E     PE E
Sbjct: 354 KSLEEATPSKEGDILKPEEE 373



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 55/289 (19%), Positives = 108/289 (37%), Gaps = 28/289 (9%)

Query: 370 PRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPH 429
           P+    P APE ++ S  E+LP+ S+E     +    G  P   A+  +  +     T  
Sbjct: 107 PKEGDIPKAPEETIQSKKEDLPKSSEEA----IQPKEGDIPKSSAKPIQPKLGNIAKTSV 162

Query: 430 QPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQ 488
           +P          +P ++ +P +P  T+Q +      + +  + P     P     P Q +
Sbjct: 163 KPS---------QPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 213

Query: 489 LTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQT 548
             + S +S E+ + P     P  L  +       +     E + P        L+   Q 
Sbjct: 214 EGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQP 272

Query: 549 FPEQLSPNPTKTYFAQEGC------SFLYEK---LPPSPS---SPGNGDCTLLALAQLRG 596
               +  +P +T   ++G         +  K   +P SP     P  GD    +L +   
Sbjct: 273 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP-KSLEEAIP 331

Query: 597 PLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQG 645
           P  +D+P  PE  + P+     +S    +  ++ +I +  ++  +  +G
Sbjct: 332 PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEG 380


>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
           sapiens]
          Length = 553

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 78/380 (20%), Positives = 138/380 (36%), Gaps = 68/380 (17%)

Query: 370 PRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
           P+    P APE ++ S  E+LP+ S K +       P      +Q +L        P   
Sbjct: 114 PKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-----NIPKAS 168

Query: 429 HQPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQ- 486
            +P          +P +  +P  P  T+Q +      +  + + P     P     P+Q 
Sbjct: 169 VKPS---------QPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 219

Query: 487 --GQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQL--TPPSTAFQAHL 542
             G + +TSV+  + + +    +  + + P     P+    P   +L   P ++      
Sbjct: 220 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV----- 274

Query: 543 DSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDV 602
             PSQ     +S +P +    +EG       LP S             L +   P   D+
Sbjct: 275 -KPSQPKEGDISKSPEEAIQPKEG------DLPKS-------------LEEAIQPKEGDI 314

Query: 603 PLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE-- 660
           P  PE  + P+   + +S     + ++ +I +  ++  Q  +G D P S E      E  
Sbjct: 315 PKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGD 373

Query: 661 ----PLGGLEPLDSNL--SLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIF 714
               P   ++P + ++  SL  A PP           +E+D    P+     +   +D  
Sbjct: 374 IPKSPKQAIQPKEGDIPKSLEEAIPP-----------KEIDIPKSPEETI--QPKEDDSP 420

Query: 715 MDLSTPDPSEEWGSGDPEAE 734
             L    PS+E     PE E
Sbjct: 421 KSLEEATPSKEGDILKPEEE 440



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 55/289 (19%), Positives = 108/289 (37%), Gaps = 28/289 (9%)

Query: 370 PRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPH 429
           P+    P APE ++ S  E+LP+ S+E     +    G  P   A+  +  +     T  
Sbjct: 174 PKEGDIPKAPEETIQSKKEDLPKSSEEA----IQPKEGDIPKSSAKPIQPKLGNIAKTSV 229

Query: 430 QPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQ 488
           +P          +P ++ +P +P  T+Q +      + +  + P     P     P Q +
Sbjct: 230 KPS---------QPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 280

Query: 489 LTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQT 548
             + S +S E+ + P     P  L  +       +     E + P        L+   Q 
Sbjct: 281 EGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQP 339

Query: 549 FPEQLSPNPTKTYFAQEGC------SFLYEK---LPPSPS---SPGNGDCTLLALAQLRG 596
               +  +P +T   ++G         +  K   +P SP     P  GD    +L +   
Sbjct: 340 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP-KSLEEAIP 398

Query: 597 PLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQG 645
           P  +D+P  PE  + P+     +S    +  ++ +I +  ++  +  +G
Sbjct: 399 PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEG 447


>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
           sapiens]
          Length = 486

 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 78/380 (20%), Positives = 138/380 (36%), Gaps = 68/380 (17%)

Query: 370 PRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
           P+    P APE ++ S  E+LP+ S K +       P      +Q +L        P   
Sbjct: 47  PKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-----NIPKAS 101

Query: 429 HQPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQ- 486
            +P          +P +  +P  P  T+Q +      +  + + P     P     P+Q 
Sbjct: 102 VKPS---------QPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 152

Query: 487 --GQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQL--TPPSTAFQAHL 542
             G + +TSV+  + + +    +  + + P     P+    P   +L   P ++      
Sbjct: 153 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV----- 207

Query: 543 DSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDV 602
             PSQ     +S +P +    +EG       LP S             L +   P   D+
Sbjct: 208 -KPSQPKEGDISKSPEEAIQPKEG------DLPKS-------------LEEAIQPKEGDI 247

Query: 603 PLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE-- 660
           P  PE  + P+   + +S     + ++ +I +  ++  Q  +G D P S E      E  
Sbjct: 248 PKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGD 306

Query: 661 ----PLGGLEPLDSNL--SLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIF 714
               P   ++P + ++  SL  A PP           +E+D    P+     +   +D  
Sbjct: 307 IPKSPKQAIQPKEGDIPKSLEEAIPP-----------KEIDIPKSPEETI--QPKEDDSP 353

Query: 715 MDLSTPDPSEEWGSGDPEAE 734
             L    PS+E     PE E
Sbjct: 354 KSLEEATPSKEGDILKPEEE 373



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 55/289 (19%), Positives = 108/289 (37%), Gaps = 28/289 (9%)

Query: 370 PRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPH 429
           P+    P APE ++ S  E+LP+ S+E     +    G  P   A+  +  +     T  
Sbjct: 107 PKEGDIPKAPEETIQSKKEDLPKSSEEA----IQPKEGDIPKSSAKPIQPKLGNIAKTSV 162

Query: 430 QPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQ 488
           +P          +P ++ +P +P  T+Q +      + +  + P     P     P Q +
Sbjct: 163 KPS---------QPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 213

Query: 489 LTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQT 548
             + S +S E+ + P     P  L  +       +     E + P        L+   Q 
Sbjct: 214 EGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQP 272

Query: 549 FPEQLSPNPTKTYFAQEGC------SFLYEK---LPPSPS---SPGNGDCTLLALAQLRG 596
               +  +P +T   ++G         +  K   +P SP     P  GD    +L +   
Sbjct: 273 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP-KSLEEAIP 331

Query: 597 PLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQG 645
           P  +D+P  PE  + P+     +S    +  ++ +I +  ++  +  +G
Sbjct: 332 PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEG 380


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 39/130 (30%), Positives = 65/130 (50%), Gaps = 5/130 (3%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR--KGVFFAGGTPLAGPTG 67
           K RRD++N  I  L  ++P       +L  L ++ +A  + R  KG+  +       P+ 
Sbjct: 117 KRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSF 176

Query: 68  LLSAQELEDIVAALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPA 126
           L   +    I+    GFL V   E GK+L++S+SVS+ L +    L   G S++D + P 
Sbjct: 177 LQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT--GQSLFDFLHPK 234

Query: 127 DHLTVRQQLT 136
           D   V++QL+
Sbjct: 235 DVAKVKEQLS 244


>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
           2 [Homo sapiens]
          Length = 328

 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 7/157 (4%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
           + RR+++ A I  L +++P   A   +   L I+ +A  +  K +   G T   G     
Sbjct: 99  RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 157

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            L+ QEL+ ++  A  GFL + + E G+++Y+S+SV+  L     +    G ++YD + P
Sbjct: 158 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 215

Query: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSA 162
            D   +R+QL+      T R+   +  T K   +QS+
Sbjct: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSS 252


>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
           sapiens]
          Length = 717

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 134/660 (20%), Positives = 227/660 (34%), Gaps = 120/660 (18%)

Query: 10  KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
           + RR+++   I  L +++P   A   +   L I+ +A  +  K +   G     G     
Sbjct: 73  RRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSMRGTGNKSTDGAYKPS 131

Query: 68  LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
            L+ QEL+ ++  A  GFL V  AE G+++Y+S+SV+  L     +    G ++Y+ + P
Sbjct: 132 FLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWF--GSTLYEQVHP 189

Query: 126 ADHLTVRQQL--------------------------TLPSALDTDRLFRCRFNTSKSLRR 159
            D   +R+QL                          ++   + + R F CR     +   
Sbjct: 190 DDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLD 249

Query: 160 QSAGNKLVLIRGRFHAHPPGAYWAGNPVF-----TAFCAPLEPR----PRPGPGPGPGPA 210
               N++  +R RF  +  G    G   +     T +     P     P      G G  
Sbjct: 250 HLPLNRITTMRKRFR-NGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSK 308

Query: 211 SLFLAM----------------------FQSRHAKDLALLDISESVLIYLGFERSELLCK 248
              +A+                      F SRH  D  +  +    +  +G++  +LL K
Sbjct: 309 YCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGK 368

Query: 249 SWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS-EGPEGP- 306
                 HPED +H      +++   G + + M  R + K   W  I    ++ + P    
Sbjct: 369 DILEFCHPEDQSHLRESFQQVVKLKGQVLSVM-YRFRTKNREWMLIRTSSFTFQNPYSDE 427

Query: 307 ---ITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLF 363
              I   N  +  ++      +++  D  ++Y L +   +P+ P  +    E   +    
Sbjct: 428 IEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDL-SQVPVPNLPAGV---HEAGKSVEKA 483

Query: 364 TAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCT 423
            A     R   F  A   + +SASE+    S     +   +  G                
Sbjct: 484 DAIFSQERDPRF--AEMFAGISASEKKMMSSASAAGTQQIYSQG---------------- 525

Query: 424 PPYTPHQPGGCAFLFS-LHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP-L 481
            P+ P    G AF  S +H P    + + SST Q     S      Q+  + +  P P  
Sbjct: 526 SPF-PSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQ 584

Query: 482 TSPLQGQLTETS-------------VRSYEDQLTPCTSTFPDQLLPSTAT----FPEPLG 524
             P Q   T++S               SY    +P TS+       S A     F E   
Sbjct: 585 QIPSQSSKTQSSPFGIGTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQ 644

Query: 525 SPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNG 584
           S    Q  P     Q       Q   EQ S         Q G + +++ + P P  P  G
Sbjct: 645 SSGQFQGRPSEVWSQWQSQHHGQQSGEQHS-------HQQPGQTEVFQDMLPMPGDPTQG 697


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.133    0.402 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,741,201
Number of Sequences: 37866
Number of extensions: 2301570
Number of successful extensions: 9349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 234
Number of HSP's that attempted gapping in prelim test: 7880
Number of HSP's gapped (non-prelim): 1073
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.