Search of human proteins with 194018490

Search of human proteins with 194018490

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018490 ATPase family, AAA domain containing 3C [Homo
sapiens]
         (411 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018490 ATPase family, AAA domain containing 3C [Homo sapiens]   811   0.0  
gi|75677353 AAA-ATPase  TOB3 [Homo sapiens]                           637   0.0  
gi|42476028 ATPase family, AAA domain containing 3A [Homo sapiens]    634   0.0  
gi|169218287 PREDICTED: similar to belphegor [Homo sapiens]           286   2e-77
gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]               61   2e-09
gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]             61   2e-09
gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]            60   3e-09
gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]                57   4e-08
gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]                57   4e-08
gi|6005942 valosin-containing protein [Homo sapiens]                   55   9e-08
gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]           55   9e-08
gi|31742536 fidgetin-like 1 [Homo sapiens]                             55   1e-07
gi|112789543 fidgetin-like 1 [Homo sapiens]                            55   1e-07
gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]          55   2e-07
gi|40806170 spastin isoform 2 [Homo sapiens]                           54   3e-07
gi|11875211 spastin isoform 1 [Homo sapiens]                           54   3e-07
gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]                       54   3e-07
gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]                        54   3e-07
gi|5901990 katanin p60 subunit A 1 [Homo sapiens]                      54   3e-07
gi|157671927 spermatogenesis associated 5 [Homo sapiens]               54   3e-07
gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]             53   4e-07
gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]      53   6e-07
gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]                  52   1e-06
gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]                  52   1e-06
gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]               52   1e-06
gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]              52   1e-06
gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]             49   6e-06
gi|40806173 spastic paraplegia 7 isoform 2 [Homo sapiens]              49   1e-05
gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]             48   1e-05
gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit ...    48   2e-05

>gi|194018490 ATPase family, AAA domain containing 3C [Homo sapiens]
          Length = 411

 Score =  811 bits (2095), Expect = 0.0
 Identities = 411/411 (100%), Positives = 411/411 (100%)

Query: 1   MSKDALNLAQMQEQTLQLEQQSKLKQLVNEDLRKQEESVQKHHQTFLESIRAAGTLFGEG 60
           MSKDALNLAQMQEQTLQLEQQSKLKQLVNEDLRKQEESVQKHHQTFLESIRAAGTLFGEG
Sbjct: 1   MSKDALNLAQMQEQTLQLEQQSKLKQLVNEDLRKQEESVQKHHQTFLESIRAAGTLFGEG 60

Query: 61  FRAFVTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEA 120
           FRAFVTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEA
Sbjct: 61  FRAFVTDRDKVTATVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEA 120

Query: 121 LRHPIQQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPG 180
           LRHPIQQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPG
Sbjct: 121 LRHPIQQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPG 180

Query: 181 TGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADA 240
           TGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADA
Sbjct: 181 TGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADA 240

Query: 241 FLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDL 300
           FLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDL
Sbjct: 241 FLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDL 300

Query: 301 PGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAV 360
           PGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAV
Sbjct: 301 PGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAV 360

Query: 361 SWQATAYASKDGVLTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS 411
           SWQATAYASKDGVLTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS
Sbjct: 361 SWQATAYASKDGVLTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS 411


>gi|75677353 AAA-ATPase  TOB3 [Homo sapiens]
          Length = 648

 Score =  637 bits (1643), Expect = 0.0
 Identities = 349/458 (76%), Positives = 368/458 (80%), Gaps = 56/458 (12%)

Query: 9   AQMQEQTLQ--LEQQSKLKQLVNED-LRKQEESVQK------------------------ 41
           AQ Q++  +   E Q K +QL+NE+ LRKQEESVQK                        
Sbjct: 130 AQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRV 189

Query: 42  ----------------------------HHQTFLESIRAAGTLFGEGFRAFVTDRDKVTA 73
                                       H QT LESIR AGTLFGEGFRAFVTDRDKVTA
Sbjct: 190 ETEARARAKAERENADIIREQIRLKASEHRQTVLESIRTAGTLFGEGFRAFVTDRDKVTA 249

Query: 74  TVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEALRHPIQQVSRRLL 133
           TVAGLTLLAVGVYSAKNATAVTGR+IEARLGKPSLVRETSRITVLEALRHPIQ VSRRLL
Sbjct: 250 TVAGLTLLAVGVYSAKNATAVTGRFIEARLGKPSLVRETSRITVLEALRHPIQ-VSRRLL 308

Query: 134 SRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPGTGKTLFAKKLALH 193
           SRPQDVLEGVVLSPSLEARVRDIAI TRN KKNRGLYRHILLYGPPGTGKTLFAKKLALH
Sbjct: 309 SRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYGPPGTGKTLFAKKLALH 368

Query: 194 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED 253
           SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLF+DEADAFLRKRATE+IS+D
Sbjct: 369 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFMDEADAFLRKRATEEISKD 428

Query: 254 LRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDLPGQEERARLVRMY 313
           LRATLNAFLY  GQHSNKFML+LAS  PEQFD AIN+ IDVMVHFDLP QEER RLVR++
Sbjct: 429 LRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINSRIDVMVHFDLPQQEERERLVRLH 488

Query: 314 LNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAVSWQATAYASKDGV 373
            +  VLKPATEGKRRLKLAQFDYGRKC E+ARLTEGMS R+IAQLAVSWQATAYASKDGV
Sbjct: 489 FDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASKDGV 548

Query: 374 LTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS 411
           LTEAMMDACVQD VQQ++Q MRWLK E PG   E P S
Sbjct: 549 LTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPLS 586



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 29/47 (61%), Positives = 34/47 (72%), Gaps = 7/47 (14%)

Query: 2   SKDALNLAQMQEQTLQLEQQSKLK-------QLVNEDLRKQEESVQK 41
           +K+ALNLAQMQEQTLQLEQQSKLK       QL +E +R Q E  +K
Sbjct: 71  AKEALNLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRAQAEERRK 117


>gi|42476028 ATPase family, AAA domain containing 3A [Homo sapiens]
          Length = 634

 Score =  634 bits (1635), Expect = 0.0
 Identities = 347/458 (75%), Positives = 364/458 (79%), Gaps = 56/458 (12%)

Query: 9   AQMQEQTLQ--LEQQSKLKQLVNED-LRKQEESVQK------------------------ 41
           AQ Q++  +   E Q K +QL+NE+ LRKQEESVQK                        
Sbjct: 178 AQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNEMLRV 237

Query: 42  ----------------------------HHQTFLESIRAAGTLFGEGFRAFVTDRDKVTA 73
                                       H QT LESIR AGTLFGEGFRAFVTD DKVTA
Sbjct: 238 EAEARARAKAERENADITREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTA 297

Query: 74  TVAGLTLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEALRHPIQQVSRRLL 133
           TVAGLTLLAVGVYSAKNAT V GR+IEARLGKPSLVRETSRITVLEALRHPIQ VSRRLL
Sbjct: 298 TVAGLTLLAVGVYSAKNATLVAGRFIEARLGKPSLVRETSRITVLEALRHPIQ-VSRRLL 356

Query: 134 SRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPGTGKTLFAKKLALH 193
           SRPQD LEGVVLSPSLEARVRDIAI TRN KKNR LYR+IL+YGPPGTGKTLFAKKLALH
Sbjct: 357 SRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKLALH 416

Query: 194 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED 253
           SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED
Sbjct: 417 SGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISED 476

Query: 254 LRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINACIDVMVHFDLPGQEERARLVRMY 313
           LRATLNAFLYRTGQHSNKFML+LAS  PEQFDWAIN  I+ MVHFDLPGQEER RLVRMY
Sbjct: 477 LRATLNAFLYRTGQHSNKFMLVLASNQPEQFDWAINDRINEMVHFDLPGQEERERLVRMY 536

Query: 314 LNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLAVSWQATAYASKDGV 373
            ++YVLKPATEGK+RLKLAQFDYGRKC E+ARLTEGMS R+IAQLAVSWQATAYAS+DGV
Sbjct: 537 FDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASEDGV 596

Query: 374 LTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPSS 411
           LTEAMMD  VQD VQQHQQ M WLK E PG  DE   S
Sbjct: 597 LTEAMMDTRVQDAVQQHQQKMCWLKAEGPGRGDEPSPS 634



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 23/24 (95%), Positives = 24/24 (100%)

Query: 2  SKDALNLAQMQEQTLQLEQQSKLK 25
          +KDALNLAQMQEQTLQLEQQSKLK
Sbjct: 71 AKDALNLAQMQEQTLQLEQQSKLK 94


>gi|169218287 PREDICTED: similar to belphegor [Homo sapiens]
          Length = 284

 Score =  286 bits (732), Expect = 2e-77
 Identities = 147/181 (81%), Positives = 159/181 (87%)

Query: 231 LLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCHPEQFDWAINA 290
           LLLF+DEADAFLRKRATE+IS+DLRATLNAFLY  GQHSNKFML+LAS  PEQFD AIN+
Sbjct: 42  LLLFMDEADAFLRKRATEEISKDLRATLNAFLYHMGQHSNKFMLVLASNLPEQFDCAINS 101

Query: 291 CIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGM 350
            IDVMVHFDLP QEER RLVR++ +  VLKPATEGKRRLKLAQFDYGRKC E+ARLTEGM
Sbjct: 102 RIDVMVHFDLPQQEERERLVRLHFDNCVLKPATEGKRRLKLAQFDYGRKCSEVARLTEGM 161

Query: 351 SCRKIAQLAVSWQATAYASKDGVLTEAMMDACVQDFVQQHQQMMRWLKGERPGPEDEQPS 410
           S R+IAQLAVSWQATAYASKDGVLTEAMMDACVQD VQQ++Q MRWLK E PG   E P 
Sbjct: 162 SGREIAQLAVSWQATAYASKDGVLTEAMMDACVQDAVQQYRQKMRWLKAEGPGRGVEHPL 221

Query: 411 S 411
           S
Sbjct: 222 S 222


>gi|4507173 spastic paraplegia 7 isoform 1 [Homo sapiens]
          Length = 795

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 62/209 (29%), Positives = 99/209 (47%), Gaps = 28/209 (13%)

Query: 174 LLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGLL 232
           LL GPPG GKTL AK +A  + + +  M G + V  +G  G   +  LF  A  +R   +
Sbjct: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEAR-ARAPCI 404

Query: 233 LFVDEADAFLRKRATEK---ISEDLRATLNAFLYR-TGQHSNKFMLILASCH-PEQFDWA 287
           +++DE DA  +KR+T      + +   TLN  L    G  +   +++LAS +  +  D A
Sbjct: 405 VYIDEIDAVGKKRSTTMSGFSNTEEEQTLNQLLVEMDGMGTTDHVIVLASTNRADILDGA 464

Query: 288 I--NACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFD--YGRKCLEI 343
           +     +D  V  DLP  +ER  +   +L            + LKL Q    Y ++   +
Sbjct: 465 LMRPGRLDRHVFIDLPTLQERREIFEQHL------------KSLKLTQSSTFYSQR---L 509

Query: 344 ARLTEGMSCRKIAQLAVSWQATAYASKDG 372
           A LT G S   IA +    +A  +A+++G
Sbjct: 510 AELTPGFSGADIANICN--EAALHAAREG 536


>gi|21361144 proteasome 26S ATPase subunit 3 [Homo sapiens]
          Length = 439

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 61/268 (22%), Positives = 121/268 (45%), Gaps = 27/268 (10%)

Query: 113 SRITVLEALRHPIQQVSR--RLLSRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLY 170
           SR+  +E    P +Q S    L  + Q+++E +VL  + + +  ++ I            
Sbjct: 170 SRVKAMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPP--------- 220

Query: 171 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRR 229
           + +L+YGPPGTGKTL A+  A  +   +  + G  +  M   +G   +   F  A   + 
Sbjct: 221 KGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFALAK-EKA 279

Query: 230 GLLLFVDEADAFLRKR-ATEKISE-DLRATLNAFLYRTG--QHSNKFMLILASCHPEQFD 285
             ++F+DE DA   KR  +EK  + +++ T+   L +    Q + +  +I A+   +  D
Sbjct: 280 PSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNTQVKVIAATNRVDILD 339

Query: 286 WAI--NACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEI 343
            A+  +  +D  + F +P +E RAR+++++  +  + P    +   +      G +C  +
Sbjct: 340 PALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVSPDVNYEELARCTDDFNGAQCKAV 399

Query: 344 ARLTEGMSCRKIAQLAVSWQATAYASKD 371
                   C +   +A+   AT    +D
Sbjct: 400 --------CVEAGMIALRRGATELTHED 419


>gi|195539395 proteasome 26S ATPase subunit 6 [Homo sapiens]
          Length = 403

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 69/312 (22%), Positives = 140/312 (44%), Gaps = 33/312 (10%)

Query: 19  EQQSKLKQLVNEDLRKQEESVQKHHQTFLESIRAAGTLFGEGFRAFVTDRDKVTATVAGL 78
           E   +LK+L  E L++  +  +K     L+++++ G + GE  +    ++  V AT    
Sbjct: 35  EIDGRLKEL-REQLKELTKQYEKSEND-LKALQSVGQIVGEVLKQLTEEKFIVKAT---- 88

Query: 79  TLLAVGVYSAKNATAVTGRYIEARLGKPSLVRETSRITVLEALRHPIQQVSRRLLSRPQD 138
                   +         R ++    KP   R    +T L  +R+  ++V   + +   +
Sbjct: 89  --------NGPRYVVGCRRQLDKSKLKPG-TRVALDMTTLTIMRYLPREVDPLVYNMSHE 139

Query: 139 VLEGVVLSP--SLEARVRDIAIMTRNIKKNRGLYRHI--------LLYGPPGTGKTLFAK 188
               V  S    L  ++R++  +      N  L++ +        LLYGPPGTGKTL A+
Sbjct: 140 DPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLAR 199

Query: 189 KLALHSGMDY-AIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRAT 247
            +A     ++  +++   V     E    + ++F++A    +  ++F+DE DA   +R +
Sbjct: 200 AVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYAR-DHQPCIIFMDEIDAIGGRRFS 258

Query: 248 EKISED--LRATLNAFLYRTGQHS--NKFMLILASCHPEQFDWAI--NACIDVMVHFDLP 301
           E  S D  ++ TL   L +       ++  +I+A+  P+  D A+     +D  +H DLP
Sbjct: 259 EGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLP 318

Query: 302 GQEERARLVRMY 313
            ++ R  +++++
Sbjct: 319 NEQARLDILKIH 330


>gi|62177112 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 42/162 (25%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 170 YRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSR 228
           ++ +L+ GPPGTGKT+ AK +A   G  +  ++   +    R E    +  LF+ A    
Sbjct: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR-FY 299

Query: 229 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---------TGQHSNKFMLILASC 279
               +F+DE D+   +R T    E  R   +  L +             S   M++ A+ 
Sbjct: 300 APTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATN 359

Query: 280 HPEQFDWAINACIDVMVHFDLPGQEERARLVRMYLNEYVLKP 321
            P   D A+   ++  ++  LP  + RA L+++ L E  L P
Sbjct: 360 FPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDP 401


>gi|14149767 katanin p60 subunit A-like 1 [Homo sapiens]
          Length = 490

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 42/162 (25%), Positives = 72/162 (44%), Gaps = 11/162 (6%)

Query: 170 YRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSR 228
           ++ +L+ GPPGTGKT+ AK +A   G  +  ++   +    R E    +  LF+ A    
Sbjct: 241 WKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMAR-FY 299

Query: 229 RGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---------TGQHSNKFMLILASC 279
               +F+DE D+   +R T    E  R   +  L +             S   M++ A+ 
Sbjct: 300 APTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATN 359

Query: 280 HPEQFDWAINACIDVMVHFDLPGQEERARLVRMYLNEYVLKP 321
            P   D A+   ++  ++  LP  + RA L+++ L E  L P
Sbjct: 360 FPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDP 401


>gi|6005942 valosin-containing protein [Homo sapiens]
          Length = 806

 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 5/147 (3%)

Query: 171 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDV-APMGREGVTAMHKLFDWANTSRR 229
           R ILLYGPPGTGKTL A+ +A  +G  + ++ G ++ + +  E  + + K F+ A  +  
Sbjct: 239 RGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAP 298

Query: 230 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCH-PEQFDWAI 288
             ++F+DE DA   KR       + R          G      ++++A+ + P   D A+
Sbjct: 299 A-IIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPAL 357

Query: 289 N--ACIDVMVHFDLPGQEERARLVRMY 313
                 D  V   +P    R  +++++
Sbjct: 358 RRFGRFDREVDIGIPDATGRLEILQIH 384



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 39/157 (24%), Positives = 74/157 (47%), Gaps = 20/157 (12%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGL 231
           +L YGPPG GKTL AK +A     ++  + G ++  M   E    + ++FD A  +    
Sbjct: 514 VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQA-APC 572

Query: 232 LLFVDEADAFLRKR---------ATEKISEDLRATLNAFLYRTGQHSNKFMLIL-ASCHP 281
           +LF DE D+  + R         A +++   +   ++      G  + K + I+ A+  P
Sbjct: 573 VLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMD------GMSTKKNVFIIGATNRP 626

Query: 282 EQFDWAI--NACIDVMVHFDLPGQEERARLVRMYLNE 316
           +  D AI     +D +++  LP ++ R  +++  L +
Sbjct: 627 DIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRK 663


>gi|7019569 vacuolar protein sorting factor 4A [Homo sapiens]
          Length = 437

 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 41/150 (27%), Positives = 75/150 (50%), Gaps = 7/150 (4%)

Query: 170 YRHILLYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAMHKLFDWANTS 227
           +R ILL+GPPGTGK+  AK +A  +     +++ +   ++    E    +  LF+ A   
Sbjct: 160 WRGILLFGPPGTGKSYLAKAVATEANNSTFFSVSSSDLMSKWLGESEKLVKNLFELAR-Q 218

Query: 228 RRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---TGQHSNKFMLILASCHPEQF 284
            +  ++F+DE D+    R  E  SE  R     FL +    G +++  +++ A+  P   
Sbjct: 219 HKPSIIFIDEVDSLCGSR-NENESEAARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVL 277

Query: 285 DWAINACIDVMVHFDLPGQEERARLVRMYL 314
           D AI    +  ++  LP +  RA++ R++L
Sbjct: 278 DSAIRRRFEKRIYIPLPEEAARAQMFRLHL 307


>gi|31742536 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 43/149 (28%), Positives = 72/149 (48%), Gaps = 7/149 (4%)

Query: 167 RGLYRHILLYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWAN 225
           RG  + ILL+GPPGTGKTL  K +A  SG   ++I      +    EG   +  LF  A 
Sbjct: 431 RGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVAR 490

Query: 226 TSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR----TGQHSNKFMLILASCHP 281
             ++  ++F+DE D+ L +R   +  E  R     FL +    T    ++ +++ A+  P
Sbjct: 491 -CQQPAVIFIDEIDSLLSQRGDGE-HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRP 548

Query: 282 EQFDWAINACIDVMVHFDLPGQEERARLV 310
           ++ D A    +   ++  LP    R ++V
Sbjct: 549 QEIDEAARRRLVKRLYIPLPEASARKQIV 577


>gi|112789543 fidgetin-like 1 [Homo sapiens]
          Length = 674

 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 43/149 (28%), Positives = 72/149 (48%), Gaps = 7/149 (4%)

Query: 167 RGLYRHILLYGPPGTGKTLFAKKLALHSGMD-YAIMTGGDVAPMGREGVTAMHKLFDWAN 225
           RG  + ILL+GPPGTGKTL  K +A  SG   ++I      +    EG   +  LF  A 
Sbjct: 431 RGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVAR 490

Query: 226 TSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR----TGQHSNKFMLILASCHP 281
             ++  ++F+DE D+ L +R   +  E  R     FL +    T    ++ +++ A+  P
Sbjct: 491 -CQQPAVIFIDEIDSLLSQRGDGE-HESSRRIKTEFLVQLDGATTSSEDRILVVGATNRP 548

Query: 282 EQFDWAINACIDVMVHFDLPGQEERARLV 310
           ++ D A    +   ++  LP    R ++V
Sbjct: 549 QEIDEAARRRLVKRLYIPLPEASARKQIV 577


>gi|17865802 vacuolar protein sorting factor 4B [Homo sapiens]
          Length = 444

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 50/187 (26%), Positives = 86/187 (45%), Gaps = 21/187 (11%)

Query: 170 YRHILLYGPPGTGKTLFAKKLALHSGMD--YAIMTGGDVAPMGREGVTAMHKLFDWANTS 227
           +R ILL+GPPGTGK+  AK +A  +     ++I +   V+    E    +  LF  A  +
Sbjct: 167 WRGILLFGPPGTGKSYLAKAVATEANNSTFFSISSSDLVSKWLGESEKLVKNLFQLAREN 226

Query: 228 RRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR---TGQHSNKFMLILASCHPEQF 284
           +   ++F+DE D+    R +E  SE  R     FL +    G  ++  +++ A+  P   
Sbjct: 227 KPS-IIFIDEIDSLCGSR-SENESEAARRIKTEFLVQMQGVGVDNDGILVLGATNIPWVL 284

Query: 285 DWAINACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIA 344
           D AI    +  ++  LP    RA + +++L          G  +  L + D+     E+ 
Sbjct: 285 DSAIRRRFEKRIYIPLPEPHARAAMFKLHL----------GTTQNSLTEADF----RELG 330

Query: 345 RLTEGMS 351
           R T+G S
Sbjct: 331 RKTDGYS 337


>gi|40806170 spastin isoform 2 [Homo sapiens]
          Length = 584

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 28/227 (12%)

Query: 137 QDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGM 196
           +  L+ +V+ PSL   +             R   R +LL+GPPG GKT+ AK +A  S  
Sbjct: 319 KQALQEIVILPSLRPEL---------FTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNA 369

Query: 197 DYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLR 255
            +  ++   + +    EG   +  LF  A   +   ++F+DE D+ L +R   +     R
Sbjct: 370 TFFNISAASLTSKYVGEGEKLVRALFAVARELQPS-IIFIDEVDSLLCERREGEHDASRR 428

Query: 256 ATLNAFLYRTGQHS---NKFMLILASCHPEQFDWAINACIDVMVHFDLPGQEERARLVRM 312
                 +   G  S   ++ +++ A+  P++ D A+       V+  LP +E R  L++ 
Sbjct: 429 LKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKN 488

Query: 313 YLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLA 359
            L +    P T+             ++  ++AR+T+G S   +  LA
Sbjct: 489 LLCKQG-SPLTQ-------------KELAQLARMTDGYSGSDLTALA 521


>gi|11875211 spastin isoform 1 [Homo sapiens]
          Length = 616

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 28/227 (12%)

Query: 137 QDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLYGPPGTGKTLFAKKLALHSGM 196
           +  L+ +V+ PSL   +             R   R +LL+GPPG GKT+ AK +A  S  
Sbjct: 351 KQALQEIVILPSLRPEL---------FTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNA 401

Query: 197 DYAIMTGGDV-APMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLR 255
            +  ++   + +    EG   +  LF  A   +   ++F+DE D+ L +R   +     R
Sbjct: 402 TFFNISAASLTSKYVGEGEKLVRALFAVARELQPS-IIFIDEVDSLLCERREGEHDASRR 460

Query: 256 ATLNAFLYRTGQHS---NKFMLILASCHPEQFDWAINACIDVMVHFDLPGQEERARLVRM 312
                 +   G  S   ++ +++ A+  P++ D A+       V+  LP +E R  L++ 
Sbjct: 461 LKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKN 520

Query: 313 YLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARLTEGMSCRKIAQLA 359
            L +    P T+             ++  ++AR+T+G S   +  LA
Sbjct: 521 LLCKQG-SPLTQ-------------KELAQLARMTDGYSGSDLTALA 553


>gi|21327685 YME1-like 1 isoform 1 [Homo sapiens]
          Length = 773

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 23/209 (11%)

Query: 169 LYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTS 227
           L + ILL GPPGTGKTL A+ +A  + + +   +G +   M    G + +  LF  A  +
Sbjct: 371 LPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAK-A 429

Query: 228 RRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR-TGQHSNKFMLIL-ASCHPEQFD 285
               ++F+DE D+   KR    +    R T+N  L    G   N+ ++I+ A+  PE  D
Sbjct: 430 NAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALD 489

Query: 286 WAI--NACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEI 343
            A+      D+ V    P  + R  +++ YLN+                +FD       I
Sbjct: 490 NALIRPGRFDMQVTVPRPDVKGRTEILKWYLNK---------------IKFDQSVDPEII 534

Query: 344 ARLTEGMSCRKIAQLAVSWQATAYASKDG 372
           AR T G S  ++  L    QA   A+ DG
Sbjct: 535 ARGTVGFSGAELENLVN--QAALKAAVDG 561


>gi|7657689 YME1-like 1 isoform 3 [Homo sapiens]
          Length = 716

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 60/209 (28%), Positives = 93/209 (44%), Gaps = 23/209 (11%)

Query: 169 LYRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTS 227
           L + ILL GPPGTGKTL A+ +A  + + +   +G +   M    G + +  LF  A  +
Sbjct: 314 LPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAK-A 372

Query: 228 RRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYR-TGQHSNKFMLIL-ASCHPEQFD 285
               ++F+DE D+   KR    +    R T+N  L    G   N+ ++I+ A+  PE  D
Sbjct: 373 NAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALD 432

Query: 286 WAI--NACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEI 343
            A+      D+ V    P  + R  +++ YLN+                +FD       I
Sbjct: 433 NALIRPGRFDMQVTVPRPDVKGRTEILKWYLNK---------------IKFDQSVDPEII 477

Query: 344 ARLTEGMSCRKIAQLAVSWQATAYASKDG 372
           AR T G S  ++  L    QA   A+ DG
Sbjct: 478 ARGTVGFSGAELENLVN--QAALKAAVDG 504


>gi|5901990 katanin p60 subunit A 1 [Homo sapiens]
          Length = 491

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 54/213 (25%), Positives = 89/213 (41%), Gaps = 13/213 (6%)

Query: 117 VLEALRHPIQQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIMTRNIKKNRGLYRHILLY 176
           ++EAL   I  +S+    R  D+ + V     L+  V     M    K  R  ++ +L+ 
Sbjct: 191 LVEALERDI--ISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMV 248

Query: 177 GPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSRRGLLLFV 235
           GPPGTGKTL AK +A      +  ++   +    R E    +  LF+ A        +F+
Sbjct: 249 GPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPA-TIFI 307

Query: 236 DEADAFLRKRATEKISEDLRATLNAFLYR---------TGQHSNKFMLILASCHPEQFDW 286
           DE D+   +R T +  E  R      L +             S   M++ A+  P   D 
Sbjct: 308 DEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDE 367

Query: 287 AINACIDVMVHFDLPGQEERARLVRMYLNEYVL 319
           A+   ++  ++  LP  + R  L+R+ L E  L
Sbjct: 368 ALRRRLEKRIYIPLPSAKGREELLRISLRELEL 400


>gi|157671927 spermatogenesis associated 5 [Homo sapiens]
          Length = 893

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 52/217 (23%), Positives = 107/217 (49%), Gaps = 16/217 (7%)

Query: 109 VRETSRITVLEALRHPIQQVSRRLLSRPQDVLEGVVLSPSLEA--RVRDIAIMTRNIKKN 166
           +  T+R+   E  ++  +Q ++  ++   D++ G  LS  L+A   + ++ +    + K+
Sbjct: 326 ISSTTRVNFTEIDKNSKEQDNQFKVT--YDMIGG--LSSQLKAIREIIELPLKQPELFKS 381

Query: 167 RGLY--RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDW 223
            G+   R +LLYGPPGTGKT+ A+ +A   G   +++ G + ++    E    + ++F  
Sbjct: 382 YGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAE 441

Query: 224 ANTSRRGLLLFVDEADAFLRKR--ATEKISEDLRATLNAFLYRTGQH--SNKFMLILASC 279
           A T R   ++F+DE DA   KR  A  ++ + + A+L   +   G      + +++ A+ 
Sbjct: 442 A-TLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQVLVLGATN 500

Query: 280 HPEQFDWAIN--ACIDVMVHFDLPGQEERARLVRMYL 314
            P   D A+      D  +   +P  ++R  +++  L
Sbjct: 501 RPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLL 537



 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 40/146 (27%), Positives = 69/146 (47%), Gaps = 7/146 (4%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVA-PMGREGVTAMHKLFDWANTSRRGL 231
           +LLYGPPG  KT+ AK LA  SG+++  + G ++      E   A+ + F  A      +
Sbjct: 664 VLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVAPSI 723

Query: 232 LLFVDEADAFLRKRATEKISEDL--RATLNAFLYRTGQHSNKFMLILASCH-PEQFDWAI 288
           + F DE DA   +R +   + ++  R          G    K + ILA+ + P++ D A+
Sbjct: 724 IFF-DELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDKAL 782

Query: 289 --NACIDVMVHFDLPGQEERARLVRM 312
                ID +++  LP    R  + ++
Sbjct: 783 MRPGRIDRIIYVPLPDAATRREIFKL 808


>gi|24497435 proteasome 26S ATPase subunit 5 [Homo sapiens]
          Length = 406

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 59/216 (27%), Positives = 92/216 (42%), Gaps = 38/216 (17%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGL 231
           +LLYGPPGTGKTL A+ +A H+   +  ++G + V     EG   + +LF  A       
Sbjct: 186 VLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAR-EHAPS 244

Query: 232 LLFVDEADAFLRKR---ATEKISEDLRATLNAFLYRTGQHSNK-FMLILASCHPEQFDWA 287
           ++F+DE D+    R    +   SE  R  L       G  + K   +I+A+   +  D A
Sbjct: 245 IIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSA 304

Query: 288 I--NACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIAR 345
           +     ID  + F  P +E R  +++++  +                             
Sbjct: 305 LLRPGRIDRKIEFPPPNEEARLDILKIHSRK---------------------------MN 337

Query: 346 LTEGMSCRKIAQLAVSWQATAYASKDGVLTEAMMDA 381
           LT G++ RKIA+L       + A   GV TEA M A
Sbjct: 338 LTRGINLRKIAEL---MPGASGAEVKGVCTEAGMYA 370


>gi|31377644 ATPase family, AAA domain containing 1 [Homo sapiens]
          Length = 361

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 54/203 (26%), Positives = 86/203 (42%), Gaps = 35/203 (17%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAMHKLFDWANTSRRGL 231
           +LLYGPPG GKTL AK  A  +G  +  +    +      E       +F  A    +  
Sbjct: 129 VLLYGPPGCGKTLIAKATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA-IKLQPS 187

Query: 232 LLFVDEADAFLRKRATEKISEDLRAT-------LNAFLYRTGQHSNKFMLILASCHPEQF 284
           ++F+DE D+FLR R+    S D  AT       ++ +      HS + +++ A+  P+  
Sbjct: 188 IIFIDEIDSFLRNRS----SSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDL 243

Query: 285 DWAINACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIA 344
           D AI   +    H + P  ++R  ++++                LK    D     LE+A
Sbjct: 244 DSAIMRRMPTRFHINQPALKQREAILKLI---------------LKNENVDRHVDLLEVA 288

Query: 345 RLTEGMS-------CRKIAQLAV 360
           + T+G S       CR  A L V
Sbjct: 289 QETDGFSGSDLKEMCRDAALLCV 311


>gi|45643125 nuclear VCP-like isoform 2 [Homo sapiens]
          Length = 750

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTSRRGL 231
           +LL GPPG GKTL AK +A  SG+++  + G ++  M   E   A+ ++F  A  S    
Sbjct: 512 VLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNS-APC 570

Query: 232 LLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCH-PEQFDWAI-- 288
           ++F DE DA   +R+  +    +R          G  + + + I+A+ + P+  D AI  
Sbjct: 571 VIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILR 630

Query: 289 NACIDVMVHFDLPGQEERARLVR 311
              +D  +   LP   +R  +++
Sbjct: 631 PGRLDKTLFVGLPPPADRLAILK 653



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 56/208 (26%), Positives = 91/208 (43%), Gaps = 36/208 (17%)

Query: 171 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 229
           R +LL+GPPG GKTL A  +A    +    +   + V+ +  E    + +LF+ A  S  
Sbjct: 193 RGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQA-VSNA 251

Query: 230 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSN------KFMLILASCHPEQ 283
             ++F+DE DA   KR  E  S+D+   + A L       N      + ++I A+  P+ 
Sbjct: 252 PCIIFIDEIDAITPKR--EVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDS 309

Query: 284 FDWAINAC--IDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQ-FDYGRKC 340
            D A+      D  +   +P +  R R+++               R+L+L Q FD+    
Sbjct: 310 LDPALRRAGRFDREICLGIPDEASRERILQTLC------------RKLRLPQAFDF---- 353

Query: 341 LEIARLTEGM-------SCRKIAQLAVS 361
             +A LT G         CR+ A  AV+
Sbjct: 354 CHLAHLTPGFVGADLMALCREAAMCAVN 381


>gi|45643123 nuclear VCP-like isoform 1 [Homo sapiens]
          Length = 856

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 40/143 (27%), Positives = 70/143 (48%), Gaps = 5/143 (3%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTSRRGL 231
           +LL GPPG GKTL AK +A  SG+++  + G ++  M   E   A+ ++F  A  S    
Sbjct: 618 VLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNS-APC 676

Query: 232 LLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLILASCH-PEQFDWAI-- 288
           ++F DE DA   +R+  +    +R          G  + + + I+A+ + P+  D AI  
Sbjct: 677 VIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLEARQQVFIMAATNRPDIIDPAILR 736

Query: 289 NACIDVMVHFDLPGQEERARLVR 311
              +D  +   LP   +R  +++
Sbjct: 737 PGRLDKTLFVGLPPPADRLAILK 759



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 56/208 (26%), Positives = 91/208 (43%), Gaps = 36/208 (17%)

Query: 171 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 229
           R +LL+GPPG GKTL A  +A    +    +   + V+ +  E    + +LF+ A  S  
Sbjct: 299 RGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFEQA-VSNA 357

Query: 230 GLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSN------KFMLILASCHPEQ 283
             ++F+DE DA   KR  E  S+D+   + A L       N      + ++I A+  P+ 
Sbjct: 358 PCIIFIDEIDAITPKR--EVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDS 415

Query: 284 FDWAINAC--IDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQ-FDYGRKC 340
            D A+      D  +   +P +  R R+++               R+L+L Q FD+    
Sbjct: 416 LDPALRRAGRFDREICLGIPDEASRERILQTLC------------RKLRLPQAFDF---- 459

Query: 341 LEIARLTEGM-------SCRKIAQLAVS 361
             +A LT G         CR+ A  AV+
Sbjct: 460 CHLAHLTPGFVGADLMALCREAAMCAVN 487


>gi|226371754 katanin p60 subunit A-like 2 [Homo sapiens]
          Length = 466

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 53/205 (25%), Positives = 91/205 (44%), Gaps = 25/205 (12%)

Query: 170 YRHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGR-EGVTAMHKLFDWANTSR 228
           ++ +LLYGPPGTGKTL AK +A      +  ++   +    R +    +  LF+ A    
Sbjct: 215 WKGLLLYGPPGTGKTLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHA 274

Query: 229 RGLLLFVDEADAFLRKRATEKISE---DLRATLNAFLYRTG-QHSNKFMLILASCH-PEQ 283
               +F+DE ++ + +R T    E    LR      +   G   S   + +LA+ + P +
Sbjct: 275 PS-TIFLDELESVMSQRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWE 333

Query: 284 FDWAINACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKL-AQFDYGRKCLE 342
            D A+   ++  +  DLP +E R  ++  +L      P     R L+L  + +Y      
Sbjct: 334 LDCAMLRRLEKRILVDLPSREARQAMIYHWL------PPVSKSRALELHTELEYS----V 383

Query: 343 IARLTEGMS-------CRKIAQLAV 360
           +++ TEG S       CR+ A   V
Sbjct: 384 LSQETEGYSGSDIKLVCREAAMRPV 408


>gi|4506209 proteasome 26S ATPase subunit 2 [Homo sapiens]
          Length = 433

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 8/148 (5%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGL 231
           +LL+GPPGTGKTL A+ +A  +   +  + G + V     EG   + +LF+ A T ++  
Sbjct: 212 VLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMART-KKAC 270

Query: 232 LLFVDEADAFLRKRATEKISED---LRATLNAFLYRTG-QHSNKFMLILASCHPEQFDWA 287
           L+F DE DA    R  +    D    R  L       G        +++A+  P+  D A
Sbjct: 271 LIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPA 330

Query: 288 I--NACIDVMVHFDLPGQEERARLVRMY 313
           +     +D  + F LP  E R  + +++
Sbjct: 331 LMRPGRLDRKIEFSLPDLEGRTHIFKIH 358


>gi|24430151 proteasome 26S ATPase subunit 1 [Homo sapiens]
          Length = 440

 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 40/154 (25%), Positives = 75/154 (48%), Gaps = 8/154 (5%)

Query: 173 ILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGL 231
           ++LYGPPGTGKTL AK +A  +   +  + G + +     +G   + +LF  A       
Sbjct: 222 VILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAE-EHAPS 280

Query: 232 LLFVDEADAFLRKR--ATEKISEDLRATLNAFLYRTGQHSNK--FMLILASCHPEQFDWA 287
           ++F+DE DA   KR  +      +++ T+   L +     ++    +I+A+   E  D A
Sbjct: 281 IVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPA 340

Query: 288 I--NACIDVMVHFDLPGQEERARLVRMYLNEYVL 319
           +     ID  + F LP ++ + R+ +++ +   L
Sbjct: 341 LIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTL 374


>gi|40806173 spastic paraplegia 7 isoform 2 [Homo sapiens]
          Length = 489

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 29/75 (38%), Positives = 43/75 (57%), Gaps = 2/75 (2%)

Query: 174 LLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRRGLL 232
           LL GPPG GKTL AK +A  + + +  M G + V  +G  G   +  LF  A  +R   +
Sbjct: 346 LLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEAR-ARAPCI 404

Query: 233 LFVDEADAFLRKRAT 247
           +++DE DA  +KR+T
Sbjct: 405 VYIDEIDAVGKKRST 419


>gi|5802970 AFG3 ATPase family gene 3-like 2 [Homo sapiens]
          Length = 797

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 55/192 (28%), Positives = 85/192 (44%), Gaps = 19/192 (9%)

Query: 174 LLYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM-GREGVTAMHKLFDWANTSRRGLL 232
           +L GPPGTGKTL AK  A  + + +  ++G +   M    G   +  LF  A       +
Sbjct: 345 ILTGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPARVRDLFALAR-KNAPCI 403

Query: 233 LFVDEADAFLRKRATEKI--SEDLRATLNAFLYR-TGQHSNKFMLILASCH-PEQFDWAI 288
           LF+DE DA  RKR         +   TLN  L    G ++   ++ILA  + P+  D A+
Sbjct: 404 LFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTTTNVVILAGTNRPDILDPAL 463

Query: 289 --NACIDVMVHFDLPGQEERARLVRMYLNEYVLKPATEGKRRLKLAQFDYGRKCLEIARL 346
                 D  +    P  + RA + +++L    L    E   + KLA+        ++A L
Sbjct: 464 LRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKLDSTLE---KDKLAR--------KLASL 512

Query: 347 TEGMSCRKIAQL 358
           T G S   +A +
Sbjct: 513 TPGFSGADVANV 524


>gi|89064750 PREDICTED: similar to proteasome 26S ATPase subunit 4
           [Homo sapiens]
          Length = 414

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 40/143 (27%), Positives = 65/143 (45%), Gaps = 8/143 (5%)

Query: 171 RHILLYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAMHKLFDWANTSRR 229
           R +L+YGPPG GKT+ AK +A H+   +  + G + V     EG   +  +F  A  +  
Sbjct: 196 RGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAP 255

Query: 230 GLLLFVDEADAFLRKRATEKISED---LRATLNAFLYRTGQHSN-KFMLILASCHPEQFD 285
             ++F+DE DA   KR   +   D    R  L       G   N    +I+A+   +  D
Sbjct: 256 A-IIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLD 314

Query: 286 WAI--NACIDVMVHFDLPGQEER 306
            A+     +D  + F LP + ++
Sbjct: 315 PALLRPGRLDRKIEFPLPDRRQK 337


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.133    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,597,561
Number of Sequences: 37866
Number of extensions: 600833
Number of successful extensions: 2749
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2629
Number of HSP's gapped (non-prelim): 122
length of query: 411
length of database: 18,247,518
effective HSP length: 105
effective length of query: 306
effective length of database: 14,271,588
effective search space: 4367105928
effective search space used: 4367105928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.