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Search of human proteins with 192447426
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
(721 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 1446 0.0
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 1420 0.0
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 1068 0.0
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 1059 0.0
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 978 0.0
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 974 0.0
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 969 0.0
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 956 0.0
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 590 e-168
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 447 e-125
gi|95089461 discs large homolog 5 [Homo sapiens] 192 9e-49
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 189 6e-48
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 165 1e-40
gi|45827729 scribble isoform b [Homo sapiens] 161 2e-39
gi|45827731 scribble isoform a [Homo sapiens] 161 2e-39
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 155 1e-37
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 152 1e-36
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 150 5e-36
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 150 5e-36
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 148 2e-35
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 147 3e-35
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 147 4e-35
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 138 2e-32
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 138 2e-32
gi|112382257 InaD-like [Homo sapiens] 135 1e-31
gi|148746189 multiple PDZ domain protein [Homo sapiens] 129 9e-30
gi|10092691 tight junction protein 3 [Homo sapiens] 127 3e-29
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 125 1e-28
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 125 1e-28
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 117 5e-26
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 1446 bits (3743), Expect = 0.0
Identities = 721/721 (100%), Positives = 721/721 (100%)
Query: 1 MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEY 60
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEY
Sbjct: 1 MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEY 60
Query: 61 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120
EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV
Sbjct: 61 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120
Query: 121 DVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI 180
DVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI
Sbjct: 121 DVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHI 180
Query: 181 PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV
Sbjct: 181 PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
Query: 241 AKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLG 300
AKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLG
Sbjct: 241 AKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLG 300
Query: 301 EEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVN 360
EEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVN
Sbjct: 301 EEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVN 360
Query: 361 GVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASL 420
GVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASL
Sbjct: 361 GVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASL 420
Query: 421 RSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETD 480
RSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETD
Sbjct: 421 RSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETD 480
Query: 481 DIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT 540
DIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT
Sbjct: 481 DIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT 540
Query: 541 KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQ 600
KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQ
Sbjct: 541 KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQ 600
Query: 601 YNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINK 660
YNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINK
Sbjct: 601 YNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINK 660
Query: 661 RITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARER 720
RITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARER
Sbjct: 661 RITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARER 720
Query: 721 L 721
L
Sbjct: 721 L 721
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 1420 bits (3675), Expect = 0.0
Identities = 711/716 (99%), Positives = 713/716 (99%), Gaps = 3/716 (0%)
Query: 9 TKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGY---VNGTEGEMEYEEITL 65
++KYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGY VNGTEGEMEYEEITL
Sbjct: 52 SQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITL 111
Query: 66 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 125
ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV
Sbjct: 112 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 171
Query: 126 THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS 185
THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS
Sbjct: 172 THSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNS 231
Query: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN
Sbjct: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 291
Query: 246 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP 305
AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP
Sbjct: 292 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIP 351
Query: 306 REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR
Sbjct: 352 REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
Query: 366 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK
Sbjct: 412 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 471
Query: 426 RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI 485
RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI
Sbjct: 472 RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI 531
Query: 486 PSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN 545
PSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN
Sbjct: 532 PSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRAN 591
Query: 546 DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL 605
DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL
Sbjct: 592 DDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHL 651
Query: 606 YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE 665
YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE
Sbjct: 652 YGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEE 711
Query: 666 QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
Sbjct: 712 QARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 767
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 1068 bits (2761), Expect = 0.0
Identities = 530/717 (73%), Positives = 615/717 (85%), Gaps = 33/717 (4%)
Query: 32 QANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSI 91
QAN PPV+VNTD+LE P YVNGT+ + EYEEITLERGNSGLGFSIAGGTDNPHIGDD SI
Sbjct: 194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
Query: 92 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPP 151
FITKII GGAAAQDGRLRVND IL VNEVDVR+VTHS AVEALKEAGSIVRLYV RRKP
Sbjct: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Query: 152 AEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 211
+EK+MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG+LQIGDK+LA
Sbjct: 314 SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLA 373
Query: 212 VNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISH 271
VN+V LE+V HE+AV ALKNT D VYLKVAKP++ Y++D YAPPDIT S SQ +DN +S
Sbjct: 374 VNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433
Query: 272 SSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE 331
SS+LG TP SP RYSPV+K +LG+++I REPR++V+HRGSTGLGFNIVGGEDGE
Sbjct: 434 SSFLG------QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGE 487
Query: 332 GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 391
GIFISFILAGGPADLSGELRKGD+I+SVN VDLR ASHEQAA ALKNAGQ VTI+AQY+P
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
Query: 392 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 451
EEYSRFEAKIHDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYDKTKD G SQ L+F
Sbjct: 548 EEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNF 607
Query: 452 RFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL-------KAKDW 504
+FGD+LHVI+ASD+EWWQAR+V D E+D++G IPSKRRVE++E +RL K +D
Sbjct: 608 KFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDK 667
Query: 505 G--------------------SSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRA 544
G S S +G+E+ VLSYE V Q EV+Y RP+IILGP KDR
Sbjct: 668 GEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRI 727
Query: 545 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 604
NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV+SRE+MEKDIQ HKFIEAGQYN+H
Sbjct: 728 NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNH 787
Query: 605 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 664
LYGTSVQSVREVAE+GKHCILDVS NA++RLQ A L+PI+IFI+P+S+EN++E+NKR+TE
Sbjct: 788 LYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTE 847
Query: 665 EQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
EQARK F+RA KLEQEFTE F+AIV+GD+ E+IY++VK++IE+ SG YIWVPA+E+L
Sbjct: 848 EQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL 904
Score = 134 bits (338), Expect = 2e-31
Identities = 108/383 (28%), Positives = 162/383 (42%), Gaps = 95/383 (24%)
Query: 8 TTKKYRYQDEDTPPLEHSPAHLPNQANSPPVI-VNTDTLEAPGYVNGTEGEMEYEEITLE 66
+ +KYRYQDEDTPP EH + N+ P ++ V+ L + G + + I+
Sbjct: 104 SVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSE---IENVHGFVSHSHISPI 160
Query: 67 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVT 126
+ + + P++ + ++P A N V + +
Sbjct: 161 KPTEAV------------LPSPPTVPVIPVLPVPAE---------------NTVILPTIP 193
Query: 127 HSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSI 186
+ L S+ + + EI L +G GLGFSIAGG N HI D+SI
Sbjct: 194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
Query: 187 YVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA 246
++TKII GGAA +DGRL++ D IL VN V + DV H AV ALK +V L V
Sbjct: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV------ 307
Query: 247 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 306
+R PV++ ++
Sbjct: 308 ------------------------------------------KRRKPVSEKIM------- 318
Query: 307 EPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKGDQILSVN 360
I + +G GLGF+I GG + I+++ I+ GG A G+L+ GD++L+VN
Sbjct: 319 ---EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 361 GVDLRNASHEQAAIALKNAGQTV 383
V L +HE+A ALKN V
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFV 398
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 1059 bits (2739), Expect = 0.0
Identities = 530/739 (71%), Positives = 615/739 (83%), Gaps = 55/739 (7%)
Query: 32 QANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSI 91
QAN PPV+VNTD+LE P YVNGT+ + EYEEITLERGNSGLGFSIAGGTDNPHIGDD SI
Sbjct: 194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
Query: 92 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPP 151
FITKII GGAAAQDGRLRVND IL VNEVDVR+VTHS AVEALKEAGSIVRLYV RRKP
Sbjct: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPV 313
Query: 152 AEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 211
+EK+MEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG+LQIGDK+LA
Sbjct: 314 SEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLA 373
Query: 212 VNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISH 271
VN+V LE+V HE+AV ALKNT D VYLKVAKP++ Y++D YAPPDIT S SQ +DN +S
Sbjct: 374 VNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSP 433
Query: 272 SSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE 331
SS+LG TP SP RYSPV+K +LG+++I REPR++V+HRGSTGLGFNIVGGEDGE
Sbjct: 434 SSFLG------QTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGE 487
Query: 332 GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 391
GIFISFILAGGPADLSGELRKGD+I+SVN VDLR ASHEQAA ALKNAGQ VTI+AQY+P
Sbjct: 488 GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547
Query: 392 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 451
EEYSRFEAKIHDLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYDKTKD G SQ L+F
Sbjct: 548 EEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNF 607
Query: 452 RFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRL-------KAKDW 504
+FGD+LHVI+ASD+EWWQAR+V D E+D++G IPSKRRVE++E +RL K +D
Sbjct: 608 KFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDK 667
Query: 505 G------------------------------------------SSSGSQGREDSVLSYET 522
G S S +G+E+ VLSYE
Sbjct: 668 GQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSYRGQEEYVLSYEP 727
Query: 523 VTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSS 582
V Q EV+Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV+S
Sbjct: 728 VNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTS 787
Query: 583 REKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHP 642
RE+MEKDIQ HKFIEAGQYN+HLYGTSVQSVREVAE+GKHCILDVS NA++RLQ A L+P
Sbjct: 788 REQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYP 847
Query: 643 IAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVK 702
I+IFI+P+S+EN++E+NKR+TEEQARK F+RA KLEQEFTE F+AIV+GD+ E+IY++VK
Sbjct: 848 ISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVK 907
Query: 703 RVIEDLSGPYIWVPARERL 721
++IE+ SG YIWVPA+E+L
Sbjct: 908 QIIEEQSGSYIWVPAKEKL 926
Score = 134 bits (338), Expect = 2e-31
Identities = 108/383 (28%), Positives = 162/383 (42%), Gaps = 95/383 (24%)
Query: 8 TTKKYRYQDEDTPPLEHSPAHLPNQANSPPVI-VNTDTLEAPGYVNGTEGEMEYEEITLE 66
+ +KYRYQDEDTPP EH + N+ P ++ V+ L + G + + I+
Sbjct: 104 SVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSE---IENVHGFVSHSHISPI 160
Query: 67 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVT 126
+ + + P++ + ++P A N V + +
Sbjct: 161 KPTEAV------------LPSPPTVPVIPVLPVPAE---------------NTVILPTIP 193
Query: 127 HSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSI 186
+ L S+ + + EI L +G GLGFSIAGG N HI D+SI
Sbjct: 194 QANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSI 253
Query: 187 YVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNA 246
++TKII GGAA +DGRL++ D IL VN V + DV H AV ALK +V L V
Sbjct: 254 FITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV------ 307
Query: 247 YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR 306
+R PV++ ++
Sbjct: 308 ------------------------------------------KRRKPVSEKIM------- 318
Query: 307 EPRRIVIHRGSTGLGFNIVGGEDGE------GIFISFILAGGPADLSGELRKGDQILSVN 360
I + +G GLGF+I GG + I+++ I+ GG A G+L+ GD++L+VN
Sbjct: 319 ---EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 361 GVDLRNASHEQAAIALKNAGQTV 383
V L +HE+A ALKN V
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFV 398
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 978 bits (2528), Expect = 0.0
Identities = 484/714 (67%), Positives = 580/714 (81%), Gaps = 43/714 (6%)
Query: 51 VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 110
VNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFITKIIPGGAAA+DGRLRV
Sbjct: 36 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 95
Query: 111 NDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFS 170
ND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P E V+EIKL KGPKGLGFS
Sbjct: 96 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFS 155
Query: 171 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALK 230
IAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+ LE+V HE+AVA LK
Sbjct: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
Query: 231 NTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 290
NT +VVYLKV KP+ Y++D Y PPDIT SYS ++N + + +Y T++ P SP R
Sbjct: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
Query: 291 YSPVAKDLLGEED-----------------------IPREPRRIVIHRGSTGLGFNIVGG 327
YSP+ K +L ++D + EPR++V+H+GSTGLGFNIVGG
Sbjct: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG 335
Query: 328 EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIA 387
EDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK AGQTVTIIA
Sbjct: 336 EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIA 395
Query: 388 QYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ 447
QY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA+FDYDK+KD G SQ
Sbjct: 396 QYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ 455
Query: 448 ALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSS 507
LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVER+E +RLK + +
Sbjct: 456 GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAK 515
Query: 508 SG--------------------SQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDD 547
G +G+ED +LSYE VT+ E++Y RP+IILGP KDR NDD
Sbjct: 516 PGVIDSKGDIPGLGDDGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDD 575
Query: 548 LLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYG 607
L+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +LYG
Sbjct: 576 LISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYG 635
Query: 608 TSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQA 667
TSVQSVR VAE+GKHCILDVS NA++RLQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA
Sbjct: 636 TSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQA 695
Query: 668 RKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
+K +DRA KLEQEF E F+AIV+GD+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 696 KKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 749
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 974 bits (2517), Expect = 0.0
Identities = 511/867 (58%), Positives = 611/867 (70%), Gaps = 149/867 (17%)
Query: 3 CLCIVTT--KKYRYQDEDTPPLEHSPAHLPNQANSP------------------------ 36
C C + T KKYRYQDED P +HS L ++ P
Sbjct: 5 CYCALRTNVKKYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSH 63
Query: 37 ---------PVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGD 87
P+IVNTDTL+ YVNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGD
Sbjct: 64 ISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGD 123
Query: 88 DPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
DP IFITKIIPGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV R
Sbjct: 124 DPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183
Query: 148 RKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 207
R+P E V+EIKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD
Sbjct: 184 RRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGD 243
Query: 208 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDN 267
++L VN+ LE+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N
Sbjct: 244 RLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMEN 303
Query: 268 EISHSSYLGTDYPTAMTP-------------------------------------TSPRR 290
+ + +Y T++ P SPR
Sbjct: 304 HLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRH 363
Query: 291 YSPVAKD---------------LLGEEDIPR-----------------------EPRRIV 312
YSPV D LL + ++ EPR++V
Sbjct: 364 YSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVV 423
Query: 313 IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
+H+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQA
Sbjct: 424 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 483
Query: 373 AIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRA 432
A ALK AGQTVTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA
Sbjct: 484 AAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRA 543
Query: 433 LFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVE 492
+FDYDK+KD G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVE
Sbjct: 544 MFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVE 603
Query: 493 RREWSRLKAKDWGSSSG--------------------------------------SQGRE 514
R+E +RLK + + G +G+E
Sbjct: 604 RKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQE 663
Query: 515 DSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDG 574
D +LSYE VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DG
Sbjct: 664 DLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDG 723
Query: 575 RDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRR 634
RDYHFV SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA++R
Sbjct: 724 RDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKR 783
Query: 635 LQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSF 694
LQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD+
Sbjct: 784 LQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTL 843
Query: 695 EEIYHKVKRVIEDLSGPYIWVPARERL 721
E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 844 EDIYNQCKLVIEEQSGPFIWIPSKEKL 870
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 969 bits (2504), Expect = 0.0
Identities = 507/857 (59%), Positives = 606/857 (70%), Gaps = 147/857 (17%)
Query: 11 KYRYQDEDTPPLEHSPAHLPNQANSP---------------------------------P 37
KYRYQDED P +HS L ++ P P
Sbjct: 120 KYRYQDEDAPH-DHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAP 178
Query: 38 VIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKII 97
+IVNTDTL+ YVNGTE E E+EEITLERGNSGLGFSIAGGTDNPHIGDDP IFITKII
Sbjct: 179 IIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKII 238
Query: 98 PGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVME 157
PGGAAA+DGRLRVND IL VNEVDV EV+HS AVEALKEAGSIVRLYV RR+P E V+E
Sbjct: 239 PGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVE 298
Query: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217
IKL KGPKGLGFSIAGGVGNQHIPGDNSIYVTKII+GGAA KDGRLQ+GD++L VN+ L
Sbjct: 299 IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 358
Query: 218 EDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT 277
E+V HE+AVA LKNT +VVYLKV KP+ Y++D Y PPDIT SYS ++N + +
Sbjct: 359 EEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTL 418
Query: 278 DYPTAMTP-------------------------------------TSPRRYSPVAKD--- 297
+Y T++ P SPR YSPV D
Sbjct: 419 EYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSF 478
Query: 298 ------------LLGEEDIPR-----------------------EPRRIVIHRGSTGLGF 322
LL + ++ EPR++V+H+GSTGLGF
Sbjct: 479 LLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF 538
Query: 323 NIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT 382
NIVGGEDGEGIF+SFILAGGPADLSGEL++GDQILSVNG+DLR ASHEQAA ALK AGQT
Sbjct: 539 NIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 598
Query: 383 VTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDC 442
VTIIAQY+PE+Y+RFEAKIHDLREQ+MN S+ SG+ SLR+N KR Y+RA+FDYDK+KD
Sbjct: 599 VTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDS 658
Query: 443 GFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAK 502
G SQ LSF++GD+LHVI+ASD+EWWQARRV + +++++G IPSKRRVER+E +RLK
Sbjct: 659 GLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTV 718
Query: 503 DWGSSSG--------------------------------------SQGREDSVLSYETVT 524
+ + G +G+ED +LSYE VT
Sbjct: 719 KFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVT 778
Query: 525 QMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSRE 584
+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPKR+YE+DGRDYHFV SRE
Sbjct: 779 RQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISRE 838
Query: 585 KMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 644
+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDVS NA++RLQ A L+PIA
Sbjct: 839 QMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIA 898
Query: 645 IFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRV 704
IFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+AIV+GD+ E+IY++ K V
Sbjct: 899 IFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLV 958
Query: 705 IEDLSGPYIWVPARERL 721
IE+ SGP+IW+P++E+L
Sbjct: 959 IEEQSGPFIWIPSKEKL 975
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 956 bits (2472), Expect = 0.0
Identities = 469/699 (67%), Positives = 571/699 (81%), Gaps = 29/699 (4%)
Query: 51 VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 110
VNG++G +YEEI LERGNSGLGFSIAGG DNPH+ DDP IFITKIIPGGAAA DGRL V
Sbjct: 120 VNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGV 179
Query: 111 NDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFS 170
ND +L VNEVDV EV HS AVEALKEAG +VRL V RR+PP E +ME+ L+KGPKGLGFS
Sbjct: 180 NDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPETIMEVNLLKGPKGLGFS 239
Query: 171 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALK 230
IAGG+GNQHIPGDNSIY+TKIIEGGAA KDGRLQIGD++LAVN+ L+DV HE+AVA+LK
Sbjct: 240 IAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLK 299
Query: 231 NTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG--------TDYPTA 282
NT D+VYLKVAKP + +L+D YAPPD ++++ DN ISH+S LG YP A
Sbjct: 300 NTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYP-A 358
Query: 283 MTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGG 342
P RYSP+ + +L EED REPR+I++H+GSTGLGFNIVGGEDGEGIF+SFILAGG
Sbjct: 359 PPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGG 418
Query: 343 PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIH 402
PADLSGELR+GD+ILSVNGV+LRNA+HEQAA ALK AGQ+VTI+AQY+PEEYSRFE+KIH
Sbjct: 419 PADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIH 478
Query: 403 DLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDA 462
DLREQ+MNSS+ SG+ SLR++ KR Y+RALFDYD+T+D SQ LSF +GD+LHVI+A
Sbjct: 479 DLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINA 538
Query: 463 SDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLK--------------------AK 502
SD+EWWQAR V E++ IG IPSK+RVE++E +RLK +
Sbjct: 539 SDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNRDFPGLSD 598
Query: 503 DWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPH 562
D+ + +G+ED++LSYE VT+ E+HYARP+IILGP KDR NDDL+SEFP KFGSCVPH
Sbjct: 599 DYYGAKNLKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPH 658
Query: 563 TTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKH 622
TTRP+R+ E+DG+DYHFV SRE+MEKDIQ +KFIEAGQ+N +LYGTS+QSVR VAE+GKH
Sbjct: 659 TTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKH 718
Query: 623 CILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFT 682
CILDVS NA++RLQ A L+PIAIFI+P+S+E ++E+N+R T EQA K +D+A KLEQEF
Sbjct: 719 CILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFG 778
Query: 683 ECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
E F+AIV+GDS EEIY+K+K++IED SG YIWVP+ E+L
Sbjct: 779 EYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 817
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 590 bits (1521), Expect = e-168
Identities = 293/468 (62%), Positives = 364/468 (77%), Gaps = 52/468 (11%)
Query: 306 REPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
REPR+I++H+GSTGLGFNIVGGEDGEGIF+SFILAGGPADLSGELR+GD+ILSVNGV+LR
Sbjct: 45 REPRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 104
Query: 366 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
NA+HEQAA ALK AGQ+VTI+AQY+PEEYSRFE+KIHDLREQ+MNSS+ SG+ SLR++ K
Sbjct: 105 NATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 164
Query: 426 RGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFI 485
R Y+RALFDYD+T+D SQ LSF +GD+LHVI+ASD+EWWQAR V E++ IG I
Sbjct: 165 RSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVI 224
Query: 486 PSKRRVER-----------------------------------REWSRLKAKD------- 503
PSK+RVE+ R++ K+K+
Sbjct: 225 PSKKRVEKKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESS 284
Query: 504 ----------WGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFP 553
S S S+G+ED++LSYE VT+ E+HYARP+IILGP KDR NDDL+SEFP
Sbjct: 285 IQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFP 344
Query: 554 DKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSV 613
KFGSCVPHTTRP+R+ E+DG+DYHFV SRE+MEKDIQ +KFIEAGQ+N +LYGTS+QSV
Sbjct: 345 HKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSV 404
Query: 614 REVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDR 673
R VAE+GKHCILDVS NA++RLQ A L+PIAIFI+P+S+E ++E+N+R T EQA K +D+
Sbjct: 405 RAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDK 464
Query: 674 ATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
A KLEQEF E F+AIV+GDS EEIY+K+K++IED SG YIWVP+ E+L
Sbjct: 465 AMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPSPEKL 512
Score = 68.6 bits (166), Expect = 2e-11
Identities = 47/136 (34%), Positives = 69/136 (50%), Gaps = 8/136 (5%)
Query: 59 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
E +I L +G++GLGF+I GG D IF++ I+ GG A G LR D IL VN
Sbjct: 46 EPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILSVN 99
Query: 119 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK-GPKGLGFSIAGGVGN 177
V++R TH A ALK AG V + V + +P E K+ + + S++ G G+
Sbjct: 100 GVNLRNATHEQAAAALKRAGQSVTI-VAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGS 158
Query: 178 QHIPGDNSIYVTKIIE 193
S+YV + +
Sbjct: 159 LRTSEKRSLYVRALFD 174
Score = 60.1 bits (144), Expect = 7e-09
Identities = 35/79 (44%), Positives = 46/79 (58%), Gaps = 6/79 (7%)
Query: 152 AEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILA 211
A + +I L KG GLGF+I GG + I+V+ I+ GG A G L+ GD+IL+
Sbjct: 44 AREPRKIILHKGSTGLGFNIVGGEDGE------GIFVSFILAGGPADLSGELRRGDRILS 97
Query: 212 VNSVGLEDVMHEDAVAALK 230
VN V L + HE A AALK
Sbjct: 98 VNGVNLRNATHEQAAAALK 116
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 447 bits (1150), Expect = e-125
Identities = 213/334 (63%), Positives = 270/334 (80%), Gaps = 20/334 (5%)
Query: 408 LMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW 467
+MN S+ SG+ SLR+N KR Y+RA+FDYDK+KD G SQ LSF++GD+LHVI+ASD+EW
Sbjct: 1 MMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEW 60
Query: 468 WQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGS----------------- 510
WQARRV + +++++G IPSKRRVER+E +RLK + + G
Sbjct: 61 WQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGYGT 120
Query: 511 ---QGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPK 567
+G+ED +LSYE VT+ E++Y RP+IILGP KDR NDDL+SEFPDKFGSCVPHTTRPK
Sbjct: 121 KTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPK 180
Query: 568 REYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 627
R+YE+DGRDYHFV SRE+MEKDIQ HKFIEAGQYN +LYGTSVQSVR VAE+GKHCILDV
Sbjct: 181 RDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDV 240
Query: 628 SANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSA 687
S NA++RLQ A L+PIAIFI+PRSLE ++E+NKR+TEEQA+K +DRA KLEQEF E F+A
Sbjct: 241 SGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTA 300
Query: 688 IVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL 721
IV+GD+ E+IY++ K VIE+ SGP+IW+P++E+L
Sbjct: 301 IVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL 334
>gi|95089461 discs large homolog 5 [Homo sapiens]
Length = 1919
Score = 192 bits (488), Expect = 9e-49
Identities = 160/636 (25%), Positives = 279/636 (43%), Gaps = 128/636 (20%)
Query: 149 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208
+P E+ +K+ KG + LG SI G IYV+K+ G AH+ G L+ GD+
Sbjct: 1342 RPYVEEPRHVKVQKGSEPLGISIVSGE-------KGGIYVSKVTVGSIAHQAG-LEYGDQ 1393
Query: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 268
+L N + L + A + D + + + + S++ S HLD
Sbjct: 1394 LLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSSHSRS------SSHLDPA 1447
Query: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR----------------EPRRIV 312
+HS+ G+ TP P P+ + G P EPR +
Sbjct: 1448 GTHSTLQGSG---TTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDANKKTLEPRVVF 1504
Query: 313 IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
I + LG ++ GG + G+F++ + PA L GD IL +D+RN + E+
Sbjct: 1505 IKKSQLELGVHLCGG-NLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDVRNKTVEEV 1563
Query: 373 AIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRA 432
+ + V + QY+PEE+++ + P FYIRA
Sbjct: 1564 YVEMLKPRDGVRLKVQYRPEEFTK-----------------------AKGLPGDSFYIRA 1600
Query: 433 LFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSDSETDDIGFIPSK- 488
L YD+ D + Q LSF+ D+L+V D + W A ++ +++ G IPSK
Sbjct: 1601 L--YDRLAD---VEQELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKY 1655
Query: 489 -------RRVE------------------RREWSRLKAK---------------DWGSSS 508
RR+ RR + R K K D SS
Sbjct: 1656 VMDQEFSRRLSMSEVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSD 1715
Query: 509 GSQGREDSV-LSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPK 567
EDSV L+Y+ V +++ RP++ILGP D + L++E P KF C +
Sbjct: 1716 SIPLFEDSVSLAYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMK-- 1773
Query: 568 REYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV 627
+S++ +E+ ++ F++ + + H T+V S++E+ E+ +HC+LD+
Sbjct: 1774 -------------ASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI 1820
Query: 628 SANAVRRLQAAHLHPIAIFIRPRSLENVLE------INKRITEEQARKAFDRATKLEQEF 681
+ +A+ RL H++PI IFI +S +++ E + ++T+ +++ F+ A KLEQE+
Sbjct: 1821 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY 1880
Query: 682 TECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPA 717
+ F+ +++G + I ++ ++ +W+PA
Sbjct: 1881 SRYFTGVIQGGALSSICTQILAMVNQEQNKVLWIPA 1916
Score = 95.1 bits (235), Expect = 2e-19
Identities = 67/206 (32%), Positives = 105/206 (50%), Gaps = 23/206 (11%)
Query: 40 VNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPG 99
++TD++E V E E E E+I L+ LGF +A G + P D IF+TK+ G
Sbjct: 609 IDTDSMEWETEV--VEFERETEDIDLK----ALGFDMAEGVNEPCFPGDCGIFVTKVDKG 662
Query: 100 GAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKV---M 156
A DGRLRVND +L +N+VD+ A++AL + + V RRK KV +
Sbjct: 663 SIA--DGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPL 720
Query: 157 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 216
I L G K G S+ +N +Y ++ G A K+G L +GD+I+A+N +
Sbjct: 721 HINL-SGQKDSGISL-----------ENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768
Query: 217 LEDVMHEDAVAALKNTYDVVYLKVAK 242
L++ + + L++ D + L + K
Sbjct: 769 LDNKSLNECESLLRSCQDSLTLSLLK 794
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 5/73 (6%)
Query: 318 TGLGFNIVGGEDG-----EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQA 372
T L N+ G +D G++ + +L G PA G L GD+I+++NG+ L N S +
Sbjct: 718 TPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNEC 777
Query: 373 AIALKNAGQTVTI 385
L++ ++T+
Sbjct: 778 ESLLRSCQDSLTL 790
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 189 bits (481), Expect = 6e-48
Identities = 130/428 (30%), Positives = 201/428 (46%), Gaps = 73/428 (17%)
Query: 331 EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIA--- 387
+ + IS I+ GG A+ SG L +GD++L +NG+++R + L + T+T +
Sbjct: 276 DSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPS 335
Query: 388 -QYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD----C 442
Q KP E IH ++A FDYD + D C
Sbjct: 336 QQIKPPPAK--ETVIH---------------------------VKAHFDYDPSDDPYVPC 366
Query: 443 GFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERRE------- 495
L LSF+ GD+LHVI D WWQA R + G +P K ++RE
Sbjct: 367 RELG--LSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIE 424
Query: 496 -----------WSRLKAKD------WGSSSGSQGREDSVLSYETVT--QMEVHYARPIII 536
W K K + ++ + +L+YE ++ + RPII+
Sbjct: 425 EDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIIL 484
Query: 537 LGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAH 593
+GP N+ L+++ D+F S VPHTTR +R+ E+ GRDYHFVS R+ E DI A
Sbjct: 485 IGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVS-RQAFEADIAAG 543
Query: 594 KFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLE 653
KFIE G++ +LYGTS+ SVR+V GK C+L + +++ L+ + L P IFI P S E
Sbjct: 544 KFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQE 603
Query: 654 NVLEI----NKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLS 709
+ + K E+ R+ ++ ++EQ F + ++ Y ++ R+I L
Sbjct: 604 RLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLD 663
Query: 710 GPYIWVPA 717
WVP+
Sbjct: 664 TEPQWVPS 671
Score = 37.7 bits (86), Expect = 0.038
Identities = 17/58 (29%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 215
+K+++ K + V N+ +S+ +++I++GGAA K G L GD++L +N +
Sbjct: 254 VKIVRIEKARDIPLGATVRNEM----DSVIISRIVKGGAAEKSGLLHEGDEVLEINGI 307
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 165 bits (418), Expect = 1e-40
Identities = 136/480 (28%), Positives = 203/480 (42%), Gaps = 90/480 (18%)
Query: 293 PVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRK 352
P+ +D+ EED + R + + LG I E I ++ I+ GG AD SG +
Sbjct: 125 PMPEDIDDEEDSVKIIRLV---KNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHV 181
Query: 353 GDQILSVNGVDLRNASHEQAAIALKNAGQTVTI-IAQYKPEEYSRFEAKIHDLREQLMNS 411
GD++ VNG+ + + E+ L + +T I EE E K+
Sbjct: 182 GDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKM---------- 231
Query: 412 SLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ--ALSFRFGDVLHVIDASDEEWWQ 469
+I+ALFDY+ +D + LSF+ GD+L ++ D WWQ
Sbjct: 232 -----------------FIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQ 274
Query: 470 ARRVHSDSETDDIGFIPSKRRVERR------------------------EWSRLKAKD-- 503
A+ H G IPSK ERR + RL KD
Sbjct: 275 AK--HEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKK 332
Query: 504 -----WGSSSGSQGREDSVLSYETVT----QMEVHYARPIIILGPTKDRAND---DLLSE 551
+ Q V +YE VT Q Y R ++++GP N+ LL
Sbjct: 333 TNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKY-RLVVLVGPVGVGLNELKRKLLIS 391
Query: 552 FPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQ 611
+G VPHTTR +R E DG +Y F+S + E D+Q +KFIE G+Y ++ YGTS+
Sbjct: 392 DTQHYGVTVPHTTRARRSQESDGVEYIFIS-KHLFETDVQNNKFIEYGEYKNNYYGTSID 450
Query: 612 SVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR---------- 661
SVR V + K C+LDV + V+ L+ P IFI+P S+E + E K
Sbjct: 451 SVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQ 510
Query: 662 -----ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
TEE ++ A +E ++ F I+ D ++++K + L WVP
Sbjct: 511 GAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVP 570
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/88 (27%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 153 EKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAV 212
+ V I+L+K + LG +I + +I V +I+ GGAA + G + +GD++ V
Sbjct: 135 DSVKIIRLVKNREPLGATI------KKDEQTGAIIVARIMRGGAADRSGLIHVGDELREV 188
Query: 213 NSVGLEDVMHEDAVAALKNTYDVVYLKV 240
N + +ED E+ + L + + K+
Sbjct: 189 NGIPVEDKRPEEIIQILAQSQGAITFKI 216
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 161 bits (407), Expect = 2e-39
Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)
Query: 58 MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114
+E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D +
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 115 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 150
L VN V ++ H AVEAL+ AG+ V++ V R +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 151 ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 194
P E ++ L + +GLGFSIAGG G+ + GD I+V++I EG
Sbjct: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
GAAH+ G LQ+GD++L++N V + + H+ AV+ L A P+ A L + A
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
Query: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
+ S L + ++ + T T TP P S L + P I +
Sbjct: 952 GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
Query: 315 RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
R LG +IVGG D G+FIS +L G A SG LR GD+IL+VNG D+R
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 366 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
+A+H++A AL ++++ + P E I + + S+ G NP+
Sbjct: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
Score = 120 bits (300), Expect = 6e-27
Identities = 89/236 (37%), Positives = 120/236 (50%), Gaps = 21/236 (8%)
Query: 21 PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVN--------GTEGEMEYEEITLERGNSGL 72
PL HS P A + T T PG + EG EEI L R L
Sbjct: 958 PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
Query: 73 GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129
G SI GG+D+ P +P +FI+K++P G AA+ G LRV D IL VN DVR+ TH
Sbjct: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
Query: 130 AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 184
AV AL + L V RR P + E+ + K P + LG SI GG GN P D
Sbjct: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
Query: 185 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
I+++K+ GAA +DGRL++G ++L VN L + H +AV L++ D + + V
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 107 bits (266), Expect = 5e-23
Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)
Query: 65 LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 123
L R GLGFSIAGG + P+ D IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 124 EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 156
E H AV L A + L + R PP V
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 157 -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 194
EI+L + LG SI GG + P + ++++K++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
G A + G L++GD+ILAVN + D H++AV+AL + L V + AP
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
Query: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
P + Q E S G G PR+P
Sbjct: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
Query: 315 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
EGIFIS + G A G LR G ++L VN L +H +A
Sbjct: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
Query: 375 ALKNAGQTVTII 386
L++ G T+T++
Sbjct: 1176 LLRSVGDTLTVL 1187
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 72 LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
LG SI GG NP D IFI+K+ P GAA +DGRLRV +L VN+ + +TH
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 128 SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 179
AV+ L+ G + + V E + L P + A G+G+++
Sbjct: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 161 bits (407), Expect = 2e-39
Identities = 135/420 (32%), Positives = 199/420 (47%), Gaps = 66/420 (15%)
Query: 58 MEYEEITLE--RGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114
+E EE+TL R GLG SIAGG + P+ GDD IFI+++ G AA+ G +RV D +
Sbjct: 722 IEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKL 780
Query: 115 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP------------------------ 150
L VN V ++ H AVEAL+ AG+ V++ V R +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERR 840
Query: 151 ---------PAEKVMEIK------LIKGPKGLGFSIAGGVGNQ-HIPGDNSIYVTKIIEG 194
P E ++ L + +GLGFSIAGG G+ + GD I+V++I EG
Sbjct: 841 GGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEG 900
Query: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
GAAH+ G LQ+GD++L++N V + + H+ AV+ L A P+ A L + A
Sbjct: 901 GAAHRAGTLQVGDRVLSINGVDVTEARHDHAVS---------LLTAASPTIALLLEREAG 951
Query: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
+ S L + ++ + T T TP P S L + P I +
Sbjct: 952 GPLPPS---PLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLP 1008
Query: 315 RGSTGLGFNIVGGEDGE---------GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
R LG +IVGG D G+FIS +L G A SG LR GD+IL+VNG D+R
Sbjct: 1009 RAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVR 1067
Query: 366 NASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK 425
+A+H++A AL ++++ + P E I + + S+ G NP+
Sbjct: 1068 DATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPR 1127
Score = 120 bits (300), Expect = 6e-27
Identities = 89/236 (37%), Positives = 120/236 (50%), Gaps = 21/236 (8%)
Query: 21 PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVN--------GTEGEMEYEEITLERGNSGL 72
PL HS P A + T T PG + EG EEI L R L
Sbjct: 958 PLPHSS---PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPL 1014
Query: 73 GFSIAGGTDN---PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129
G SI GG+D+ P +P +FI+K++P G AA+ G LRV D IL VN DVR+ TH
Sbjct: 1015 GLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQE 1073
Query: 130 AVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGP-KGLGFSIAGGV----GNQHIPGDN 184
AV AL + L V RR P + E+ + K P + LG SI GG GN P D
Sbjct: 1074 AVSALLRPCLELSLLV-RRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDE 1132
Query: 185 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
I+++K+ GAA +DGRL++G ++L VN L + H +AV L++ D + + V
Sbjct: 1133 GIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188
Score = 107 bits (266), Expect = 5e-23
Identities = 103/372 (27%), Positives = 146/372 (39%), Gaps = 99/372 (26%)
Query: 65 LERGNSGLGFSIAGGTDN-PHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVR 123
L R GLGFSIAGG + P+ D IF+++I GGAA + G L+V D +L +N VDV
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 124 EVTHSAAVEALKEAGSIVRLYVMRR-------------KPPAEKVM-------------- 156
E H AV L A + L + R PP V
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGL 984
Query: 157 -------------------EIKLIKGPKGLGFSIAGGVGNQHIP---GDNSIYVTKIIEG 194
EI+L + LG SI GG + P + ++++K++
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 195 GAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAP 254
G A + G L++GD+ILAVN + D H++AV+AL + L V + AP
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDP--------AP 1095
Query: 255 PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH 314
P + Q E S G G PR+P
Sbjct: 1096 PGLRELCIQKAPGERLGISIRG--------------------GARGHAGNPRDPT----- 1130
Query: 315 RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
EGIFIS + G A G LR G ++L VN L +H +A
Sbjct: 1131 ---------------DEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQ 1175
Query: 375 ALKNAGQTVTII 386
L++ G T+T++
Sbjct: 1176 LLRSVGDTLTVL 1187
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/112 (34%), Positives = 56/112 (50%), Gaps = 7/112 (6%)
Query: 72 LGFSIAGGT----DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
LG SI GG NP D IFI+K+ P GAA +DGRLRV +L VN+ + +TH
Sbjct: 1111 LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTH 1170
Query: 128 SAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQH 179
AV+ L+ G + + V E + L P + A G+G+++
Sbjct: 1171 GEAVQLLRSVGDTLTVLVC---DGFEASTDAALEVSPGVIANPFAAGIGHRN 1219
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 155 bits (392), Expect = 1e-37
Identities = 124/480 (25%), Positives = 218/480 (45%), Gaps = 42/480 (8%)
Query: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPR-RIVIHRGSTG--LGFNIV 325
++H Y PTSP + G+ D+ R R+V + +T +G +
Sbjct: 447 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 506
Query: 326 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT- 384
E I ++ I+ GG G L GD+I +NG+ + N + EQ L+ ++T
Sbjct: 507 MNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 565
Query: 385 -IIAQYKPEEYSRFEAKIHDLREQLMN--SSLGSGTASLRSN--PK-RGFYIRALFDYDK 438
I+ Y+ + S R+ N SS + + L S PK R Y+RA F+YD
Sbjct: 566 KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP 625
Query: 439 TKD--CGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR-- 494
KD + FR GD++ +I D WWQ + +S + T G IPS E R
Sbjct: 626 AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGT--AGLIPSPELQEWRVA 683
Query: 495 ---------------EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGP 539
W K K + ++ D V +YE V ++ + +++LG
Sbjct: 684 CIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLV-TYEEVVKLPAFKRKTLVLLGA 742
Query: 540 T---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFI 596
+ + L+++ PD+F +PHTTRP ++ E +G++Y+FVS ++M +DI ++++
Sbjct: 743 HGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVS-HDQMMQDISNNEYL 801
Query: 597 EAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVL 656
E G + +YGT ++++R++ EQG ILDV A++ L+ A P +FI ++ L
Sbjct: 802 EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGL 861
Query: 657 EINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
+E ++ + L++ + F + + +E ++ +E + WVP
Sbjct: 862 N-----EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 916
Score = 37.4 bits (85), Expect = 0.049
Identities = 31/123 (25%), Positives = 50/123 (40%), Gaps = 9/123 (7%)
Query: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
N V +I+ GG H+ G L +GD+I +N + + + E L+ + K+ P
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIV-P 569
Query: 244 SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPR-------RYSPVAK 296
S S S +TS Q N S ++ +D P+ P + Y P
Sbjct: 570 SYRTQSSSCERDSPSTS-RQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKD 628
Query: 297 DLL 299
DL+
Sbjct: 629 DLI 631
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 152 bits (384), Expect = 1e-36
Identities = 124/466 (26%), Positives = 206/466 (44%), Gaps = 72/466 (15%)
Query: 287 SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADL 346
SP + + + +P + RI+ G + + + I+ IL GG D
Sbjct: 106 SPPSSPEMNNSSINNQLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHGGMIDR 165
Query: 347 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLRE 406
G L GD I VNG ++ N E + LKN +VT+
Sbjct: 166 QGLLHVGDIIKEVNGHEVGNNPKELQEL-LKNISGSVTL--------------------- 203
Query: 407 QLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD--CGFLSQALSFRFGDVLHVIDASD 464
+++ S + T P++ F ++ FDY+ D L F G++L +++ D
Sbjct: 204 KILPSYRDTIT------PQQVF-VKCHFDYNPYNDNLIPCKEAGLKFSKGEILQIVNRED 256
Query: 465 EEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDS-------- 516
WWQA V E G IPS+ E+R+ +DW +S G S
Sbjct: 257 PNWWQASHV---KEGGSAGLIPSQFLEEKRK--AFVRRDWDNSGPFCGTISSKKKKKMMY 311
Query: 517 ------------VLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEF----PDKFGSCV 560
+ YE V +M + ++++G + L + F P +FG+ V
Sbjct: 312 LTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIG-AQGVGRRSLKNRFIVLNPTRFGTTV 370
Query: 561 PHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQG 620
P T+R RE E DG+ Y FVS R +ME DI+A K++E G+Y +LYGT + S+ EV + G
Sbjct: 371 PFTSRKPREDEKDGQAYKFVS-RSEMEADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTG 429
Query: 621 KHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRI----------TEEQARKA 670
+ CILDV+ A++ L+ + P +FI LE + ++K + T+ +K
Sbjct: 430 RTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGITTKLLTDSDLKKT 489
Query: 671 FDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
D + ++++ + F I+ D+ ++ + K++ IE L WVP
Sbjct: 490 VDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVP 535
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 150 bits (378), Expect = 5e-36
Identities = 119/475 (25%), Positives = 213/475 (44%), Gaps = 55/475 (11%)
Query: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPR-RIVIHRGSTG--LGFNIV 325
++H Y PTSP + G+ D+ R R+V + +T +G +
Sbjct: 447 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 506
Query: 326 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT- 384
E I ++ I+ GG G L GD+I +NG+ + N + EQ L+ ++T
Sbjct: 507 MNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 565
Query: 385 -IIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD-- 441
I+ Y+ + S E L +++ G R Y+RA F+YD KD
Sbjct: 566 KIVPSYRTQSSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDL 607
Query: 442 CGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR------- 494
+ FR GD++ +I D WWQ + +S + T G IPS E R
Sbjct: 608 IPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGT--AGLIPSPELQEWRVACIAME 665
Query: 495 ----------EWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT---K 541
W K K + ++ D V +YE V ++ + +++LG +
Sbjct: 666 KTKQEQQASCTWFGKKKKQYKDKYLAKHNADLV-TYEEVVKLPAFKRKTLVLLGAHGVGR 724
Query: 542 DRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQY 601
+ L+++ PD+F +PHTTRP ++ E +G++Y+FVS ++M +DI ++++E G +
Sbjct: 725 RHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVS-HDQMMQDISNNEYLEYGSH 783
Query: 602 NSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKR 661
+YGT ++++R++ EQG ILDV A++ L+ A P +FI ++ L
Sbjct: 784 EDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLN---- 839
Query: 662 ITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
+E ++ + L++ + F + + +E ++ +E + WVP
Sbjct: 840 -EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 893
Score = 33.9 bits (76), Expect = 0.54
Identities = 15/57 (26%), Positives = 27/57 (47%)
Query: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
N V +I+ GG H+ G L +GD+I +N + + + E L+ + K+
Sbjct: 511 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 567
Score = 30.0 bits (66), Expect = 7.8
Identities = 28/123 (22%), Positives = 46/123 (37%), Gaps = 6/123 (4%)
Query: 50 YVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNP-----HIGDDPSIFITKIIPGGAAAQ 104
Y+NG E ++ +E TD P + + + +I+ GG +
Sbjct: 467 YLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHR 526
Query: 105 DGRLRVNDSILFVNEVDVREVTHSAAVEALKE-AGSIVRLYVMRRKPPAEKVMEIKLIKG 163
G L V D I +N + V T + L+E GSI V + + ++
Sbjct: 527 QGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQ 586
Query: 164 PKG 166
PKG
Sbjct: 587 PKG 589
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 150 bits (378), Expect = 5e-36
Identities = 107/408 (26%), Positives = 186/408 (45%), Gaps = 68/408 (16%)
Query: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEY 394
++ IL GG G L GD+IL +NG ++ N S +Q A+K +++ + P +
Sbjct: 96 VARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISL--KVIPNQQ 153
Query: 395 SRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD--CGFLSQALSFR 452
SR P ++RA FDYD KD L F
Sbjct: 154 SRL--------------------------PALQMFMRAQFDYDPKKDNLIPCKEAGLKFA 187
Query: 453 FGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREW---------------- 496
GD++ +I+ D WWQ R S E+ G IPS E +EW
Sbjct: 188 TGDIIQIINKDDSNWWQGRVEGSSKES--AGLIPSP---ELQEWRVASMAQSAPSEAPSC 242
Query: 497 ----SRLKAKD-WGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPT---KDRANDDL 548
+ K KD + + S + V+SYE V ++ + ++++G + + + L
Sbjct: 243 SPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNAL 302
Query: 549 LSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 608
LS+ P+KF VP+TTRP R+ E DG++YHF+S+ E+M ++I A++F+E G Y +++GT
Sbjct: 303 LSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFIST-EEMTRNISANEFLEFGSYQGNMFGT 361
Query: 609 SVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQAR 668
++V ++ +Q K ILD+ ++ ++ A L P +FI P E +++ ++
Sbjct: 362 KFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKD--- 418
Query: 669 KAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
+ + ++ F + + +E K++ + WVP
Sbjct: 419 -----SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVP 461
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 185 SIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
S V +I+ GG H+ G L +GD+IL +N + + + A+K T ++ LKV
Sbjct: 93 SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKV 148
Score = 34.7 bits (78), Expect = 0.32
Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 12/129 (9%)
Query: 85 IGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLY 144
+ + S + +I+ GG + G L V D IL +N +V + +A+KE ++ L
Sbjct: 88 LNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLK 147
Query: 145 VM----RRKPPAEKVMEIKLIKGP--------KGLGFSIAGGVGNQHIPGDNSIYVTKII 192
V+ R P + M + P K G A G Q I D+S + +
Sbjct: 148 VIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRV 207
Query: 193 EGGAAHKDG 201
EG + G
Sbjct: 208 EGSSKESAG 216
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 148 bits (373), Expect = 2e-35
Identities = 128/502 (25%), Positives = 213/502 (42%), Gaps = 84/502 (16%)
Query: 258 TTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGS 317
T + H+ E S L T A SP + +P + R+V R +
Sbjct: 87 TAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKT 146
Query: 318 TGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 377
G + +G + I+ IL GG G L GD I VNG + S +A
Sbjct: 147 AGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV--GSDPRA----- 199
Query: 378 NAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK-------RGFYI 430
L+E L N+S G+ L+ P R ++
Sbjct: 200 --------------------------LQELLRNAS---GSVILKILPSYQEPHLPRQVFV 230
Query: 431 RALFDYDKTKDCGFLSQALSFRF--GDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSK 488
+ FDYD +D + RF GD+L +++ D WWQA V S G IPS+
Sbjct: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSA----GLIPSQ 286
Query: 489 RRVERR--------EWSRLKAKDWGSSSGSQGRE-------------DSVLSYETVTQME 527
E+R E + GS SG + + +L YE V +M
Sbjct: 287 LLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMP 346
Query: 528 VHYARPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSRE 584
+ ++++G + + L+ PD++G+ VP+T+R ++ E +G+ Y FVS R
Sbjct: 347 PFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVS-RG 405
Query: 585 KMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 644
+ME D++A +++E G+Y +LYGT + S+R V GK C+LDV+ AV+ L+ A P
Sbjct: 406 EMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYV 465
Query: 645 IFIRPRSLENVLEIN----------KRITEEQARKAFDRATKLEQEFTECFSAIVEGDSF 694
+FI E + +N K++TE R+ + ++++++ + F + +
Sbjct: 466 VFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNL 525
Query: 695 EEIYHKVKRVIEDLSGPYIWVP 716
E + +++ +E L WVP
Sbjct: 526 ERTFRELQTAMEKLRTEPQWVP 547
Score = 30.4 bits (67), Expect = 6.0
Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 28/129 (21%)
Query: 18 DTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIA 77
+TPP SP P +N P V D + G + T GE + G+ F +
Sbjct: 116 ETPP--PSPGLDPTFSNQP---VPPDAVRMVG-IRKTAGE-----------HLGVTFRVE 158
Query: 78 GGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEA 137
GG + I +I+ GG AQ G L V D I VN V A E L+ A
Sbjct: 159 GG----------ELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGS-DPRALQELLRNA 207
Query: 138 GSIVRLYVM 146
V L ++
Sbjct: 208 SGSVILKIL 216
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 147 bits (371), Expect = 3e-35
Identities = 115/479 (24%), Positives = 215/479 (44%), Gaps = 58/479 (12%)
Query: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPR-RIVIHRGSTG--LGFNIV 325
++H Y PTSP + G+ D+ R R+V + +T +G +
Sbjct: 441 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLK 500
Query: 326 GGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVT- 384
E I ++ I+ GG G L GD+I +NG+ + N + EQ L+ ++T
Sbjct: 501 MNELNHCI-VARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF 559
Query: 385 -IIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKD-- 441
I+ Y+ + S E L +++ G R Y+RA F+YD KD
Sbjct: 560 KIVPSYRTQSSSC---------EDLPSTTQPKG---------RQIYVRAQFEYDPAKDDL 601
Query: 442 CGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKR---------RVE 492
+ FR GD++ +I D WWQ + +S + T G IPS +E
Sbjct: 602 IPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGT--AGLIPSPELQEWRVACIAME 659
Query: 493 RREWSRLKAKDWGSSSGSQGRED------------SVLSYETVTQMEVHYARPIIILGPT 540
+ + + + W Q ++ +++YE V ++ + +++LG
Sbjct: 660 KTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAH 719
Query: 541 ---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIE 597
+ + L+++ PD+F +PHTTRP ++ E +G++Y+FVS ++M +DI ++++E
Sbjct: 720 GVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVS-HDQMMQDISNNEYLE 778
Query: 598 AGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLE 657
G + +YGT ++++R++ EQG ILDV A++ L+ A P +FI ++ L
Sbjct: 779 YGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLN 838
Query: 658 INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVP 716
+E ++ + L++ + F + + +E ++ +E + WVP
Sbjct: 839 -----EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVP 892
Score = 33.9 bits (76), Expect = 0.54
Identities = 15/57 (26%), Positives = 27/57 (47%)
Query: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
N V +I+ GG H+ G L +GD+I +N + + + E L+ + K+
Sbjct: 505 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKI 561
Score = 30.0 bits (66), Expect = 7.8
Identities = 28/123 (22%), Positives = 46/123 (37%), Gaps = 6/123 (4%)
Query: 50 YVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNP-----HIGDDPSIFITKIIPGGAAAQ 104
Y+NG E ++ +E TD P + + + +I+ GG +
Sbjct: 461 YLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHR 520
Query: 105 DGRLRVNDSILFVNEVDVREVTHSAAVEALKE-AGSIVRLYVMRRKPPAEKVMEIKLIKG 163
G L V D I +N + V T + L+E GSI V + + ++
Sbjct: 521 QGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDLPSTTQ 580
Query: 164 PKG 166
PKG
Sbjct: 581 PKG 583
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 147 bits (370), Expect = 4e-35
Identities = 126/484 (26%), Positives = 213/484 (44%), Gaps = 98/484 (20%)
Query: 301 EEDIPREPRRIV-IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 359
+ED E +IV + + LG I E + ++ I+ GG AD SG + GD++ V
Sbjct: 127 DEDFDEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 360 NGVDLRNASHEQAAIALKNAGQTVTI-IAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 418
NG+ + + ++ + L + ++T+ I EE E+K+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKV----------------- 229
Query: 419 SLRSNPKRGFYIRALFDYDKTKDCGFLSQ--ALSFRFGDVLHVIDASDEEWWQARRVHSD 476
++RALF Y+ +D Q L F+ VL V+ D WWQA+RV
Sbjct: 230 ----------FMRALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDT 279
Query: 477 SETDDIGFIPSKRRVER------------------------------------------- 493
+ G IPSK ER
Sbjct: 280 NLR--AGLIPSKGFQERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVA 337
Query: 494 --REWSRLKAKD--WGSSSG--SQGRED-SVLSYETVTQMEVHYA---RPIIILGPTKDR 543
R RL ++ GS G S G E +L+YE V + + R ++++G R
Sbjct: 338 GLRRSFRLGCRERLGGSQEGKMSSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGAR 397
Query: 544 AND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQ 600
++ +++E P FG VPHTTRP++ +E +G +YHFVS ++ E D+ +KF+E G+
Sbjct: 398 LHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVS-KQAFEADLHHNKFLEHGE 456
Query: 601 YNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLEN------ 654
Y +LYGTS+++++ V + K C++DV A+++L+ + P IF++P E
Sbjct: 457 YKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPM 516
Query: 655 --VLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPY 712
E +EQ ++ A +++ + A++ + + Y ++K V+E LS
Sbjct: 517 SPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDT 576
Query: 713 IWVP 716
WVP
Sbjct: 577 HWVP 580
Score = 37.4 bits (85), Expect = 0.049
Identities = 22/88 (25%), Positives = 45/88 (51%), Gaps = 6/88 (6%)
Query: 153 EKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAV 212
E V ++L+K + LG +I ++H ++ V +I+ GGAA + G + +GD++ V
Sbjct: 133 ESVKIVRLVKNKEPLGATIRR---DEH---SGAVVVARIMRGGAADRSGLVHVGDELREV 186
Query: 213 NSVGLEDVMHEDAVAALKNTYDVVYLKV 240
N + + ++ L + + LK+
Sbjct: 187 NGIAVLHKRPDEISQILAQSQGSITLKI 214
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 138 bits (348), Expect = 2e-32
Identities = 128/475 (26%), Positives = 196/475 (41%), Gaps = 96/475 (20%)
Query: 274 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGI 333
Y P P SP V + E+ I R ++V R +G + GG D GI
Sbjct: 389 YAQVGQPDVDLPVSPS--DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGI 445
Query: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTIIAQYKP 391
F++ +L PA G L +GDQIL VN VD N E+A + L + G+ VTI+AQ K
Sbjct: 446 FVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK 504
Query: 392 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 451
+ Y R ++ S +G FYIR F+Y+K G LSF
Sbjct: 505 DVYRR-----------IVESDVGDS-----------FYIRTHFEYEKESPYG-----LSF 537
Query: 452 RFGDVLHVIDA---SDEEWWQARRVHSDSETDDIGFIPSKRRVE---------------- 492
G+V V+D W A R+ + + + G IP+K R E
Sbjct: 538 NKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD 597
Query: 493 RREWSRLKAKDWGSSSGSQGRED--------SVLSYETVTQMEVHYARPIIILGPTKDRA 544
R ++ R + + + RED +YE V E + RP+ I GP D A
Sbjct: 598 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVA 657
Query: 545 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 604
+ L E PD Y+I + + ++ I+ H
Sbjct: 658 REKLAREEPD--------------IYQIAKSEPRDAGTDQRSSGIIRLH----------- 692
Query: 605 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 664
+++++ +Q KH +LDV+ NAV RL A +PI +F+ P S + V + R+
Sbjct: 693 -------TIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCP 745
Query: 665 E---QARKAFDRATKLEQEFTECFSAIVEGDSFEE-IYHKVKRVIEDLSGPYIWV 715
E ARK ++R+ KL + F+ + +S + Y +K I+ +WV
Sbjct: 746 ESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 63.5 bits (153), Expect = 6e-10
Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 16/234 (6%)
Query: 166 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED 224
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V +++V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 225 AVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD------ 278
AV L+ + + + + + S P+ + + +E H G
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 279 ----YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIF 334
+P + + R SP + P +P ++ + + + G IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
Query: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
+ I A G +++GD +L +NG N S A ++ + + ++ Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 62.0 bits (149), Expect = 2e-09
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 4/93 (4%)
Query: 59 EYEEITLERGNS-GLGFSIAGGTDNPHI-GDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
E +TL R G G +I+GG DNPH + SI I+ ++ GG A +G+L+ ND +
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
Query: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 149
VN V + V H+ AV+ L+++G ++ + R+K
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK 110
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/135 (32%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 295 AKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 346
AK EE E + +HR G G I GG D GE I IS +L GGPA+
Sbjct: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
Query: 347 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK-----------PE--- 392
G+L++ D++ VNGV + N H A L+ +G+ I + K PE
Sbjct: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
Query: 393 --EYSRFEAKIHDLR 405
E ++ +IHD R
Sbjct: 126 DNEEDSYDEEIHDPR 140
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/74 (37%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 158 IKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 215
+KL+K KG +G +AGG D I+V ++E A K+G L+ GD+IL VN+V
Sbjct: 422 MKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
Query: 216 GLEDVMHEDAVAAL 229
+++ E+AV L
Sbjct: 474 DFTNIIREEAVLFL 487
Score = 36.6 bits (83), Expect = 0.084
Identities = 26/105 (24%), Positives = 47/105 (44%)
Query: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
I+V +I + A +DG +Q GD +L +N E++ DA ++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 246 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 290
A L + D S + ++IS L +D+ PRR
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRR 310
Score = 35.0 bits (79), Expect = 0.24
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 10/93 (10%)
Query: 67 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVT 126
R +G +AGG +D IF+ ++ AA++G L D IL VN VD +
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 127 HSAAVEALKE--AGSIVRLYVMRRKPPAEKVME 157
AV L + G V + ++K +++E
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 138 bits (348), Expect = 2e-32
Identities = 128/475 (26%), Positives = 196/475 (41%), Gaps = 96/475 (20%)
Query: 274 YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGI 333
Y P P SP V + E+ I R ++V R +G + GG D GI
Sbjct: 389 YAQVGQPDVDLPVSPS--DGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGND-VGI 445
Query: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNA--GQTVTIIAQYKP 391
F++ +L PA G L +GDQIL VN VD N E+A + L + G+ VTI+AQ K
Sbjct: 446 FVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK 504
Query: 392 EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSF 451
+ Y R ++ S +G FYIR F+Y+K G LSF
Sbjct: 505 DVYRR-----------IVESDVGDS-----------FYIRTHFEYEKESPYG-----LSF 537
Query: 452 RFGDVLHVIDA---SDEEWWQARRVHSDSETDDIGFIPSKRRVE---------------- 492
G+V V+D W A R+ + + + G IP+K R E
Sbjct: 538 NKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGD 597
Query: 493 RREWSRLKAKDWGSSSGSQGRED--------SVLSYETVTQMEVHYARPIIILGPTKDRA 544
R ++ R + + + RED +YE V E + RP+ I GP D A
Sbjct: 598 RADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVA 657
Query: 545 NDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSH 604
+ L E PD Y+I + + ++ I+ H
Sbjct: 658 REKLAREEPD--------------IYQIAKSEPRDAGTDQRSSGIIRLH----------- 692
Query: 605 LYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITE 664
+++++ +Q KH +LDV+ NAV RL A +PI +F+ P S + V + R+
Sbjct: 693 -------TIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCP 745
Query: 665 E---QARKAFDRATKLEQEFTECFSAIVEGDSFEE-IYHKVKRVIEDLSGPYIWV 715
E ARK ++R+ KL + F+ + +S + Y +K I+ +WV
Sbjct: 746 ESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 63.5 bits (153), Expect = 6e-10
Identities = 51/234 (21%), Positives = 98/234 (41%), Gaps = 16/234 (6%)
Query: 166 GLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHED 224
G G +I+GG N H G+ SI ++ +++GG A +G+LQ D++ VN V +++V H
Sbjct: 33 GFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAMVNGVSMDNVEHAF 90
Query: 225 AVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD------ 278
AV L+ + + + + + S P+ + + +E H G
Sbjct: 91 AVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRR 150
Query: 279 ----YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIF 334
+P + + R SP + P +P ++ + + + G IF
Sbjct: 151 SEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEY---GLRLASHIF 207
Query: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
+ I A G +++GD +L +NG N S A ++ + + ++ Q
Sbjct: 208 VKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQ 261
Score = 62.0 bits (149), Expect = 2e-09
Identities = 34/93 (36%), Positives = 55/93 (59%), Gaps = 4/93 (4%)
Query: 59 EYEEITLERGNS-GLGFSIAGGTDNPHI-GDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
E +TL R G G +I+GG DNPH + SI I+ ++ GG A +G+L+ ND +
Sbjct: 20 EQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPA--EGQLQENDRVAM 77
Query: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK 149
VN V + V H+ AV+ L+++G ++ + R+K
Sbjct: 78 VNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKK 110
Score = 52.0 bits (123), Expect = 2e-06
Identities = 44/135 (32%), Positives = 61/135 (45%), Gaps = 26/135 (19%)
Query: 295 AKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGED------GE-GIFISFILAGGPADL 346
AK EE E + +HR G G I GG D GE I IS +L GGPA+
Sbjct: 8 AKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAE- 66
Query: 347 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYK-----------PE--- 392
G+L++ D++ VNGV + N H A L+ +G+ I + K PE
Sbjct: 67 -GQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS 125
Query: 393 --EYSRFEAKIHDLR 405
E ++ +IHD R
Sbjct: 126 DNEEDSYDEEIHDPR 140
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/74 (37%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 158 IKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV 215
+KL+K KG +G +AGG D I+V ++E A K+G L+ GD+IL VN+V
Sbjct: 422 MKLVKFRKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNV 473
Query: 216 GLEDVMHEDAVAAL 229
+++ E+AV L
Sbjct: 474 DFTNIIREEAVLFL 487
Score = 36.6 bits (83), Expect = 0.084
Identities = 26/105 (24%), Positives = 47/105 (44%)
Query: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
I+V +I + A +DG +Q GD +L +N E++ DA ++ + + + V +
Sbjct: 206 IFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDER 265
Query: 246 AYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 290
A L + D S + ++IS L +D+ PRR
Sbjct: 266 ATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRR 310
Score = 35.0 bits (79), Expect = 0.24
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 10/93 (10%)
Query: 67 RGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVT 126
R +G +AGG +D IF+ ++ AA++G L D IL VN VD +
Sbjct: 428 RKGDSVGLRLAGG-------NDVGIFVAGVLEDSPAAKEG-LEEGDQILRVNNVDFTNII 479
Query: 127 HSAAVEALKE--AGSIVRLYVMRRKPPAEKVME 157
AV L + G V + ++K +++E
Sbjct: 480 REEAVLFLLDLPKGEEVTILAQKKKDVYRRIVE 512
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 135 bits (340), Expect = 1e-31
Identities = 107/331 (32%), Positives = 159/331 (48%), Gaps = 32/331 (9%)
Query: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
I + +G SGLG SI GG D P +I I ++ GAAA+DGRL D IL VN VD+
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDL 1493
Query: 123 REVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLI------KGPKGLGFSIAGGVG 176
R +H A+ AL++ VRL V R + +++ K +GLG SI G
Sbjct: 1494 RNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN 1553
Query: 177 NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 236
+ ++++ I++GGAA DGRL GD+IL+VN + + E LK +V
Sbjct: 1554 G------SGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLV 1607
Query: 237 YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTA---MTPTSPRRYSP 293
L++ + + + TTS + + +HSS + P +R S
Sbjct: 1608 QLEIGRLRAGSWTSAR-----TTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSD 1662
Query: 294 VAKDLLGEEDIPREPRRIVIHRG-STGLGFNIVGGEDGE----GIFISFILAGGPADLSG 348
++ G + EPR + I+R S LG +I GG +FI+ I A G A +
Sbjct: 1663 PSQKNSGTD---MEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719
Query: 349 ELRKGDQILSVNGVDLRNASHEQAAIALKNA 379
+L+ GD+I+S+NG L SH LKNA
Sbjct: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNA 1750
Score = 120 bits (302), Expect = 3e-27
Identities = 101/399 (25%), Positives = 162/399 (40%), Gaps = 84/399 (21%)
Query: 61 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120
EE+ L SGLGF I GG + + + I+PGG A +DGRL+ D IL +
Sbjct: 247 EEVELINDGSGLGFGIVGGKTS-------GVVVRTIVPGGLADRDGRLQTGDHILKIGGT 299
Query: 121 DVREVTHSAAVEALKEAGSIVRLYVMRRK-------PPAEKVMEIKL----IKGP----- 164
+V+ +T + L+ G+ VR+ V R PPA + + L KGP
Sbjct: 300 NVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359
Query: 165 --------------KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210
+ LG I G VG H + IYV II G AA+ +G +Q+ DKI+
Sbjct: 360 LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIV 419
Query: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHL----- 265
AV+ V ++ + D V L+N VV+L + + + + PP + + L
Sbjct: 420 AVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPAL 479
Query: 266 ---------------DNEI-----------------------SHSSYLGTDYPTAMTPTS 287
D EI S + L + + + P
Sbjct: 480 FLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDY 539
Query: 288 PRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLS 347
+ + + + ++ + + + IH G+ + G +IS I++GGP D
Sbjct: 540 EVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHH----YISSIVSGGPVDTL 595
Query: 348 GELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386
G L+ D++L VNG+ L S +A LK T++
Sbjct: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634
Score = 103 bits (258), Expect = 4e-22
Identities = 96/354 (27%), Positives = 157/354 (44%), Gaps = 68/354 (19%)
Query: 59 EYEEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV 117
+ E I +ER ++G LGFS+ + ++G IF+ + PG A +D RL+ ND IL +
Sbjct: 131 QIEYIDIERPSTGGLGFSVVA-LRSQNLGK-VDIFVKDVQPGSVADRDQRLKENDQILAI 188
Query: 118 NEVDV-REVTHSAAVEALKEAGSIVRLYVMRRKPPAEK--------------------VM 156
N + + ++H A+ L++ +RL ++ R+P K V
Sbjct: 189 NHTPLDQNISHQQAIALLQQTTGSLRL-IVAREPVHTKSSTSSSLNDTTLPETVCWGHVE 247
Query: 157 EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVG 216
E++LI GLGF I GG + + V I+ GG A +DGRLQ GD IL +
Sbjct: 248 EVELINDGSGLGFGIVGG-------KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTN 300
Query: 217 LEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 276
++ + E L+N + V + VA+ + S PP
Sbjct: 301 VQGMTSEQVAQVLRNCGNSVRMLVARDPAGDI--SVTPP--------------------- 337
Query: 277 TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRI-VIHRGSTGLGFNIVG----GEDGE 331
P A+ P VA G + E + ++ + LG IVG GE
Sbjct: 338 --APAALPVALP----TVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGE 391
Query: 332 --GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTV 383
GI++ I+ G A +G ++ D+I++V+GV+++ ++ L+NAGQ V
Sbjct: 392 ASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVV 445
Score = 97.4 bits (241), Expect = 4e-20
Identities = 108/418 (25%), Positives = 170/418 (40%), Gaps = 75/418 (17%)
Query: 158 IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217
I+L K GLG S+AG + SI+V I G A DGR++IGD++L +N+ L
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRM----SIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 218 EDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE--------- 268
H++A A +K V L + +A + P + +S ++++
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 269 -------------------ISHSSYLGTDYPTAMT------PTSPRR------------- 290
++ S YPT ++ P +P
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 291 --YSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG--EGIFISFILAGGPADL 346
+P++ D +P + I I +G +GLG +IVGG+D I I + G A
Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAAR 1475
Query: 347 SGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLRE 406
G L GDQIL VNGVDLRN+SHE+A AL+ Q V ++ Y+ E + R E +
Sbjct: 1476 DGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV-YRDEAHYRDEENLEIFPV 1534
Query: 407 QLM-NSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDE 465
L + G G + + G +I + G L Q GD + ++ D
Sbjct: 1535 DLQKKAGRGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQ------GDQILSVNGED- 1587
Query: 466 EWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGS----SSGSQGREDSVLS 519
+ + S+ + + + + E RL+A W S S SQG + S S
Sbjct: 1588 -------MRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHS 1638
Score = 80.1 bits (196), Expect = 7e-15
Identities = 65/252 (25%), Positives = 113/252 (44%), Gaps = 26/252 (10%)
Query: 158 IKLIKGPK-GLGFSIAGGV-------GNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
+++ + P LG SI GG + + G I++ +++E A K L+ GDKI
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKG---IFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 210 LAVNSVGLEDVMHEDAVAALKNTYD-VVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNE 268
L V+ V L++ H +AV A+KN + VV++ + S + + + +Q+ D +
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQ 1185
Query: 269 ISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEE------------DIPREPRRIVIHRG 316
GT P P + + + + E+ D+P E I + +
Sbjct: 1186 EKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKD 1245
Query: 317 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
GLG ++ G +D IF+ I GPA G +R GD++L +N L SH+ A+
Sbjct: 1246 KNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305
Query: 375 ALKNAGQTVTII 386
+K A V ++
Sbjct: 1306 IIKTAPSKVKLV 1317
Score = 77.0 bits (188), Expect = 6e-14
Identities = 63/234 (26%), Positives = 108/234 (46%), Gaps = 57/234 (24%)
Query: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE-DVMHED 224
GLGFS+ + +Q++ G I+V + G A +D RL+ D+ILA+N L+ ++ H+
Sbjct: 144 GLGFSVVA-LRSQNL-GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
Query: 225 AVAALKNTYDVVYLKVAKP-------SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT 277
A+A L+ T + L VA+ +++ L+D+ P + + + ++
Sbjct: 202 AIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVE----------- 250
Query: 278 DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISF 337
+I+ GS GLGF IVGG+ G+ +
Sbjct: 251 ----------------------------------LINDGS-GLGFGIVGGKTS-GVVVRT 274
Query: 338 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKP 391
I+ GG AD G L+ GD IL + G +++ + EQ A L+N G +V ++ P
Sbjct: 275 IVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 68.2 bits (165), Expect = 3e-11
Identities = 41/92 (44%), Positives = 54/92 (58%), Gaps = 11/92 (11%)
Query: 308 PRRIVIHRG-STGLGFNIVGG----------EDGEGIFISFILAGGPADLSGELRKGDQI 356
PR + I R + LG +IVGG E+ +GIFI +L PA + L+ GD+I
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 357 LSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
L V+GVDL+NASH +A A+KNAG V I Q
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQ 1157
Score = 65.1 bits (157), Expect = 2e-10
Identities = 41/98 (41%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 150 PPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKI 209
P E ++EI KG GLG SI GG N+I + ++ E GAA +DGRL GD+I
Sbjct: 1432 PGQEMIIEIS--KGRSGLGLSIVGGKDTPL----NAIVIHEVYEEGAAARDGRLWAGDQI 1485
Query: 210 LAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAY 247
L VN V L + HE+A+ AL+ T V L V + Y
Sbjct: 1486 LEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHY 1523
Score = 55.5 bits (132), Expect = 2e-07
Identities = 29/79 (36%), Positives = 46/79 (58%), Gaps = 2/79 (2%)
Query: 167 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 226
LG SIAGG G+ GD +++ I G A + +L++GD+I+++N L+ + H D V
Sbjct: 1687 LGISIAGGRGSPL--GDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVV 1744
Query: 227 AALKNTYDVVYLKVAKPSN 245
LKN Y + L+V +N
Sbjct: 1745 NLLKNAYGRIILQVVADTN 1763
Score = 53.5 bits (127), Expect = 7e-07
Identities = 65/258 (25%), Positives = 98/258 (37%), Gaps = 58/258 (22%)
Query: 183 DNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK 242
D Y++ I+ GG G LQ D++L VN + L +AV+ LK
Sbjct: 578 DGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKE----------- 626
Query: 243 PSNAYLSDSYAPPDITTSYSQHL-DNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGE 301
PP T + L D+E S D P + P D+ E
Sbjct: 627 ----------VPPPFTLVCCRRLFDDEAS------VDEPRRTETSLPETEVDHNMDVNTE 670
Query: 302 ED-------IPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFISFILAGGPADLSGE 349
ED E + + + + GLGF+I+ +D I I ++A G A+ SG
Sbjct: 671 EDDDGELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGG 730
Query: 350 LRKGDQILSVNGVDLRNASHEQAAIALK------------------NAGQTVTIIAQYKP 391
L GD+++SVN L N S +A LK N ++ I+
Sbjct: 731 LLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSN 790
Query: 392 EEYSRFEAKIHDLREQLM 409
E+ + F IHD+ L+
Sbjct: 791 EDKTEFSGTIHDINSSLI 808
Score = 51.2 bits (121), Expect = 3e-06
Identities = 47/147 (31%), Positives = 70/147 (47%), Gaps = 20/147 (13%)
Query: 13 RYQDEDTPPLEHSPAHLPNQANSPPVIVN----TDTLEAPGYVNGTEGEM---------- 58
R + ED P +H + ++A++ +++ TDT E P G EGE
Sbjct: 1008 RREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPEREEG-EGEETPNFSHWGPP 1066
Query: 59 EYEEITLERGNSGLGFSIAGGTD---NPHIGDD-PSIFITKIIPGGAAAQDGRLRVNDSI 114
EI E N LG SI GG G++ IFI +++ A + L+ D I
Sbjct: 1067 RIVEIFREP-NVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125
Query: 115 LFVNEVDVREVTHSAAVEALKEAGSIV 141
L V+ VD++ +HS AVEA+K AG+ V
Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPV 1152
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 41/192 (21%)
Query: 92 FITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-- 149
+I+ I+ GG G L+ D +L VN + + + AV LKE L RR
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 150 ---------------PPAE----------------------KVMEIKLIKGPKGLGFSIA 172
P E +V ++L+K KGLGFSI
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSIL 701
Query: 173 GGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 232
+ P + I + ++ G A + G L GD++++VN L++ +AV LK
Sbjct: 702 D-YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAV 760
Query: 233 -YDVVYLKVAKP 243
+V+L + KP
Sbjct: 761 PPGLVHLGICKP 772
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 6/92 (6%)
Query: 306 REPRRIVIHRGSTG-LGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVN 360
R+ I I R STG LGF++V IF+ + G AD L++ DQIL++N
Sbjct: 130 RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189
Query: 361 GVDL-RNASHEQAAIALKNAGQTVTIIAQYKP 391
L +N SH+QA L+ ++ +I +P
Sbjct: 190 HTPLDQNISHQQAIALLQQTTGSLRLIVAREP 221
Score = 32.7 bits (73), Expect = 1.2
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 1/77 (1%)
Query: 59 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
E + + L + GLGFSI D P I I ++ G A + G L D ++ VN
Sbjct: 683 EVKIVELVKDCKGLGFSILDYQD-PLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 119 EVDVREVTHSAAVEALK 135
E + + + AVE LK
Sbjct: 742 EYCLDNTSLAEAVEILK 758
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 129 bits (324), Expect = 9e-30
Identities = 102/344 (29%), Positives = 156/344 (45%), Gaps = 58/344 (16%)
Query: 66 ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 125
++ GLG SI G + D +F++ I+ GG A DGRL D IL VN DVR
Sbjct: 1730 KKPGKGLGLSIVGKRN------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783
Query: 126 THSAAVEALKEAGSIVRLYVM---------------RRKPPAEKVMEIKLIKGPKG---- 166
T A LK + + + ++ A ++ ++ ++ KG
Sbjct: 1784 TQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS 1843
Query: 167 LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 226
LG SIAGGVG+ GD I++ + G A + +L++GD+I+ + E + H AV
Sbjct: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
Query: 227 AALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPT 286
LKN + ++V A D++ + S S+ G T
Sbjct: 1902 NLLKNASGSIEMQVV-----------AGGDVSVVTGHQQEPASSSLSFTGL--------T 1942
Query: 287 SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEG----IFISFILAGG 342
S S + +D LG P + + I + RG GLGF+IVGG I++ + A G
Sbjct: 1943 S----SSIFQDDLG----PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKG 1994
Query: 343 PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386
A G L++GDQI++VNG L +HE+A LK TVT++
Sbjct: 1995 AASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
Score = 123 bits (309), Expect = 5e-28
Identities = 109/361 (30%), Positives = 163/361 (45%), Gaps = 67/361 (18%)
Query: 34 NSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFI 93
+S P I +D P + G E +E + +G +GLG SI GG+D +G +I I
Sbjct: 1607 SSTPAIFASDPATCP-IIPGCETTIE-----ISKGRTGLGLSIVGGSDTL-LG---AIII 1656
Query: 94 TKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAE 153
++ GAA +DGRL D IL VN +D+R+ TH A+ L++ VRL + R + P +
Sbjct: 1657 HEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1716
Query: 154 K-----VMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 207
+ + I+L K P KGLG SI G D ++V+ I++GG A DGRL GD
Sbjct: 1717 EEEVCDTLTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGD 1770
Query: 208 KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDN 267
+IL VN + + E A LK
Sbjct: 1771 QILMVNGEDVRNATQEAVAALLK------------------------------------- 1793
Query: 268 EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGST-GLGFNIVG 326
+S S +P + + TS S K+ L E + R + + +G T LG +I G
Sbjct: 1794 -VSEGSLSSFTFPLSGSSTSESLESSSKKNALASE--IQGLRTVEMKKGPTDSLGISIAG 1850
Query: 327 GEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT 382
G IFI+ + G A + +LR GD+I+++ G +H QA LKNA +
Sbjct: 1851 GVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGS 1910
Query: 383 V 383
+
Sbjct: 1911 I 1911
Score = 123 bits (308), Expect = 7e-28
Identities = 119/383 (31%), Positives = 167/383 (43%), Gaps = 58/383 (15%)
Query: 59 EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118
E I LE+G+SGLG S+AG D + S+FI I P GAA +DGRL++ D +L +N
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
Query: 119 EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAE----------------------KVM 156
+ +H A +K A S V++ +R K K
Sbjct: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
Query: 157 EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGR 202
E + + S V + +P D + + + + E G A DGR
Sbjct: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
Query: 203 LQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYS 262
L++GD+ILAV+ + E ++ LK V L + +A DS A P + S
Sbjct: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI----HAENPDSQAVPSAAGAAS 1578
Query: 263 QHLDNEISHSSYL---GTDYPTAMTPTSPRRYSPV--AKDLLGEEDIPREPRRIVIHRGS 317
N S S + G+ P ++ TS R +P A D IP I I +G
Sbjct: 1579 GEKKNS-SQSLMVPQSGSPEPESIRNTS-RSSTPAIFASDPATCPIIPGCETTIEISKGR 1636
Query: 318 TGLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIA 375
TGLG +IVGG D I I + G A G L GDQIL VNG+DLR A+H++A
Sbjct: 1637 TGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINV 1696
Query: 376 LKNAGQTVTII-----AQYKPEE 393
L+ Q V + A YK EE
Sbjct: 1697 LRQTPQRVRLTLYRDEAPYKEEE 1719
Score = 120 bits (302), Expect = 3e-27
Identities = 97/382 (25%), Positives = 165/382 (43%), Gaps = 64/382 (16%)
Query: 61 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120
E I L SGLGF I GG + + I+PGG A Q GRL D IL + +
Sbjct: 256 ETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
Query: 121 DVREVTHSAAVEALKEAGSIVRLYVMR--------------------------------R 148
D+ ++ + L++ G+ V+L + R +
Sbjct: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
Query: 149 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208
K + +++L K +GLG +IAG +G++ + + I+V I + A DGR+QIGD+
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
Query: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDIT-------TSY 261
I+AV+ L+ ++ AV L++T V L + + ++ + D+T +
Sbjct: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
Query: 262 SQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH-RGSTGL 320
S +N +L + T + PT Y ++ ++ ED ++ ++ + G+
Sbjct: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGI 547
Query: 321 GFNIV-------GGEDGEGI---------FISFILAGGPADLSGELRKGDQILSVNGVDL 364
+ IV G GI FI +L GP SG+L GD++L VNG+ L
Sbjct: 548 NYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITL 607
Query: 365 RNASHEQAAIALKNAGQTVTII 386
+H+ LK VT++
Sbjct: 608 LGENHQDVVNILKELPIEVTMV 629
Score = 118 bits (296), Expect = 2e-26
Identities = 85/232 (36%), Positives = 117/232 (50%), Gaps = 37/232 (15%)
Query: 42 TDTLEAPGYVNGTEGEME-YEEITLERG-NSGLGFSIAGGTDNPHIGDDPSIFITKIIPG 99
+++LE+ N E++ + +++G LG SIAGG +P +GD P IFI + P
Sbjct: 1812 SESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPT 1869
Query: 100 GAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM----------RRK 149
G AAQ +LRV D I+ + +TH+ AV LK A + + V+ ++
Sbjct: 1870 GVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQ 1929
Query: 150 PPAEKVME---------------------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 188
PA + I L +GP GLGFSI GG G+ H GD IYV
Sbjct: 1930 EPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYV 1987
Query: 189 TKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240
+ GAA +DGRL+ GD+I+AVN LE V HE+AVA LK T V L V
Sbjct: 1988 KTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 106 bits (264), Expect = 9e-23
Identities = 107/412 (25%), Positives = 170/412 (41%), Gaps = 86/412 (20%)
Query: 25 SPAHLPNQANSP----PVIVNTDTLEAPG--YVNGTEGEMEYEEIT-------------- 64
SPA +P N P N + L PG ++NG E++++
Sbjct: 81 SPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFEL 140
Query: 65 LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 124
L+ + GLGFS+ G + IF+ +I G A +DGRL+ D IL +N + +
Sbjct: 141 LKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
Query: 125 -VTHSAAVEALKEAGSIVRLYVMR------------RKPPAEKVME-------------I 158
+TH A+ L++A V+L + R R P A + I
Sbjct: 199 TITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETI 258
Query: 159 KLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
+L+ GLGF I GG + V I+ GG A + GRL GD IL + L
Sbjct: 259 ELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 219 DVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD 278
+ E L+ + V L +A+ + + + AP + + S
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGA---IEERTAPTALGITLSS--------------- 353
Query: 279 YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG--GE---DGEGI 333
+PTS A GEE E + + + GLG I G G+ + GI
Sbjct: 354 -----SPTSTPELRVDASTQKGEES---ETFDVELTKNVQGLGITIAGYIGDKKLEPSGI 405
Query: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385
F+ I + G ++ GDQI++V+G +L+ +++QA L++ GQTV +
Sbjct: 406 FVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL 457
Score = 93.6 bits (231), Expect = 6e-19
Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 44/233 (18%)
Query: 159 KLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217
+L+K P G LGFS+ G G+ I+V +I EG AH+DGRL+ D+ILA+N L
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196
Query: 218 ED-VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 276
+ + H+ A++ L+ D V L +A+ S
Sbjct: 197 DQTITHQQAISILQKAKDTVQLVIARGS-------------------------------- 224
Query: 277 TDYPTAMTPTSPRRYSPVAKDLLGEEDIP---REPRRIVIHRGSTGLGFNIVGGEDGEGI 333
P ++P R SP A + P + I + +GLGF I+GG+ G+
Sbjct: 225 --LPQLVSPIVSR--SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGK-ATGV 279
Query: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386
+ IL GG AD G L GD IL + DL S EQ A L+ G V ++
Sbjct: 280 IVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLM 332
Score = 93.6 bits (231), Expect = 6e-19
Identities = 95/307 (30%), Positives = 138/307 (44%), Gaps = 79/307 (25%)
Query: 158 IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 214
I + KG LG +++ G+G + V II GGA +DGR+ IGD IL++N
Sbjct: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
Query: 215 VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSY--SQHLDN-EIS- 270
V + A A L+ S PDI +Y ++HL+ +IS
Sbjct: 1060 ESTISVTNAQARAMLRR------------------HSLIGPDIKITYVPAEHLEEFKISL 1101
Query: 271 ------------HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR--------EPRR 310
SSY G D P P ++ GEE + +PRR
Sbjct: 1102 GQQSGRVMALDIFSSYTGRDIPEL----------PEREEGEGEESELQNTAYSNWNQPRR 1151
Query: 311 IVIHRG-STGLGFNIVGGE-------DGE---GIFISFILAGGPADLSGELRKGDQILSV 359
+ + R S LG +IVGG +GE GIFI +L PA +G L+ GD+I+ V
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 360 NGVDLRNASHEQAAIALKNAGQTVTIIAQ---YKPEEYSRFEAKIHDLREQLMNSSLGSG 416
+G+DLR+ASHEQA A++ AG V + Q +P + S + +H+L + SS
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPF 1270
Query: 417 TASLRSN 423
SL+ N
Sbjct: 1271 ADSLQIN 1277
Score = 76.3 bits (186), Expect = 1e-13
Identities = 74/268 (27%), Positives = 109/268 (40%), Gaps = 21/268 (7%)
Query: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225
GLG S+ VG+ ++ ++ G G+L GD++L VN + L H+D
Sbjct: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
Query: 226 VAALKNTYDVVYL----KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPT 281
V LK V + + P+ DS DI + H+D S D
Sbjct: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVL 675
Query: 282 AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFIS 336
AMT A + E I + I + +GS GLGF+I+ +D I I
Sbjct: 676 AMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
Query: 337 FILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSR 396
++ GG A+ G L GD+++ VN V+L N+S E+A ALK A I KP S
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
Query: 397 FEAKIHDLREQLMNSSLGSGTASLRSNP 424
E + + + A L P
Sbjct: 792 EEGYVSAKEDSFLYPPHSCEEAGLADKP 819
Score = 75.9 bits (185), Expect = 1e-13
Identities = 100/407 (24%), Positives = 167/407 (41%), Gaps = 70/407 (17%)
Query: 37 PVIVNTDTLEAPGYVNGTEGEME--YEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFIT 94
PV+ TD ++ V E + I LE+G+ GLGFSI D P I I
Sbjct: 673 PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
Query: 95 KIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGS-IVRLYVMRRKP--P 151
++PGG A +DGRL D ++FVN+V++ + AVEALK A S VR+ V + P P
Sbjct: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
Query: 152 AEKVMEIK--------------------------LIKGPKGLGFSIAGGVGNQHIPGDNS 185
E + K + G + + P ++S
Sbjct: 792 EEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDS 851
Query: 186 IYVTK---IIEGGAAHKDGRLQIG----------------DKILAVNSVGLEDVMHEDAV 226
IY T+ + G++ DG L G D +L ++ + LE++ ++ +
Sbjct: 852 IYSTQASILSLHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLH-MSLEELYTQNLL 909
Query: 227 AALKNTYDVVYLKVAKPSNAYLSDSYAPPD-ITTSY---------SQHLDNEISHSSYLG 276
V + + P++ + + Y P + I Y HL +E+ S+ L
Sbjct: 910 QRQDENTPSVDISMG-PASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELP 968
Query: 277 TDYPTAMTPTSPRRYSPVAKDLLGE----EDIPRE--PRRIVIHRGSTGLGFNIVGGEDG 330
+ P + S + E +++ +E R I I +G++ LG + +DG
Sbjct: 969 SVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDG 1028
Query: 331 EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 377
G+ + I+ GG G + GD ILS+N + ++ QA L+
Sbjct: 1029 LGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
Score = 72.8 bits (177), Expect = 1e-12
Identities = 42/91 (46%), Positives = 54/91 (59%), Gaps = 2/91 (2%)
Query: 56 GEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 115
G + + ITLERG GLGFSI GG +PH GD P I++ + GAA++DGRL+ D I+
Sbjct: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQII 2009
Query: 116 FVNEVDVREVTHSAAVEALKEAGSIVRLYVM 146
VN + VTH AV LK V L V+
Sbjct: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 60.1 bits (144), Expect = 7e-09
Identities = 68/251 (27%), Positives = 94/251 (37%), Gaps = 66/251 (26%)
Query: 51 VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 110
+ G E+ ++ NSGLG S+ T H FI ++P G G+L
Sbjct: 544 IMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLFS 595
Query: 111 NDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-PPAEK-------VMEIKLIK 162
D +L VN + + H V LKE V + RR PP + + +I+L +
Sbjct: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
Query: 163 GPK-GLGFSIAGG---------------------------VGNQHI-------------- 180
P LG I G QHI
Sbjct: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
Query: 181 -------PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT- 232
P I + ++ GG A KDGRL GD+++ VN V LE+ E+AV ALK
Sbjct: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAP 775
Query: 233 YDVVYLKVAKP 243
V + VAKP
Sbjct: 776 SGTVRIGVAKP 786
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 9/96 (9%)
Query: 57 EMEYEEITLERGNSGLGFSIAGGTDNPHIGD---DPS-IFITKIIPGGAAAQDGRLRVND 112
E E ++ L + GLG +IAG +IGD +PS IF+ I A DGR+++ D
Sbjct: 372 ESETFDVELTKNVQGLGITIAG-----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
Query: 113 SILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 148
I+ V+ +++ T+ AVE L+ G V L +MRR
Sbjct: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
Score = 49.3 bits (116), Expect = 1e-05
Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 7/101 (6%)
Query: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
I + +GNS LG +++ D + + II GGA ++DGR+ + D IL +NE
Sbjct: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 123 REVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKG 163
VT++ A A+ S++ + PAE + E K+ G
Sbjct: 1063 ISVTNAQA-RAMLRRHSLIGPDIKITYVPAEHLEEFKISLG 1102
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/80 (33%), Positives = 44/80 (55%), Gaps = 10/80 (12%)
Query: 69 NSGLGFSIAGGTDNPHIGDDPS-------IFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121
+ LG SI GG +G S IFI ++ A ++G L+ D I+ V+ +D
Sbjct: 1159 SKSLGISIVGGRG---MGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMD 1215
Query: 122 VREVTHSAAVEALKEAGSIV 141
+R+ +H AVEA+++AG+ V
Sbjct: 1216 LRDASHEQAVEAIRKAGNPV 1235
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 13/135 (9%)
Query: 21 PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGT 80
PL + +L N+ P V + ++ + N + + L + GLG +I+
Sbjct: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFKN-------VQHLELPKDQGGLGIAIS--E 1499
Query: 81 DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSI 140
++ G + I + G AA DGRL+V D IL V++ V + LK A
Sbjct: 1500 EDTLSG----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT 1555
Query: 141 VRLYVMRRKPPAEKV 155
V+L + P ++ V
Sbjct: 1556 VKLTIHAENPDSQAV 1570
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 127 bits (320), Expect = 3e-29
Identities = 154/639 (24%), Positives = 244/639 (38%), Gaps = 175/639 (27%)
Query: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
+ I++ I + G A + LQ GD IL +N V +++ D ++ + + L V +
Sbjct: 231 SQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRD 290
Query: 244 SNAYL-------SDSYAPP-------------------DITTSYSQHLDNEISHSSYLGT 277
+L SDS + P D+ + SQ + I
Sbjct: 291 RGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQ 350
Query: 278 DYPTAMTPTSP------RRYSPVAKDLLGEED-----IPREPR----------------- 309
P A SP RR S V + E D +PRE
Sbjct: 351 RSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGY 410
Query: 310 ----RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
R+V +G + GG D GIF+S + AG PAD G +++GDQIL VN V +
Sbjct: 411 SPDTRVVRFLKGKSIGLRLAGGND-VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQ 468
Query: 366 NASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSN 423
N + E+A L G+ + ++ Q K D+ +++ S +G
Sbjct: 469 NLTREEAVQFLLGLPPGEEMELVTQRK-----------QDIFWKMVQSRVGDS------- 510
Query: 424 PKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDA---------SDEEWWQARRVH 474
FYIR F+ + + G L F GDV HV+D + W A R+
Sbjct: 511 ----FYIRTHFELEPSPPSG-----LGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMG 561
Query: 475 SDSETDDIGFIPSKRRVE------------------------RREWSRLKAKDWGSSSGS 510
D + G IP++ R E R E+ RL+ G+ +
Sbjct: 562 RDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTT 621
Query: 511 Q-GRED-SVLS-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKF--GSC 559
Q RED S L+ YE V E + RP++ILGP D A L +E PD+F
Sbjct: 622 QRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAET 681
Query: 560 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQ 619
V T P + ++D +VR +AE+
Sbjct: 682 VSRTDSPSKIIKLD--------------------------------------TVRVIAEK 703
Query: 620 GKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATK 676
KH +LDV+ +A+ RL +PI +F P S + + + + + R+ + +A K
Sbjct: 704 DKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQK 763
Query: 677 LEQEFTECFSAIVE-GDSFEEIYHKVKRVIEDLSGPYIW 714
L + + F+A + + + Y ++K +I + IW
Sbjct: 764 LRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIW 802
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/247 (26%), Positives = 94/247 (38%), Gaps = 49/247 (19%)
Query: 160 LIKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
L K P+ G G +I+GG + PG S+ V+ ++ GG A +GRLQ GD I+ VN V +E
Sbjct: 33 LSKDPRRGFGIAISGG---RDRPG-GSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSME 86
Query: 219 DVMHEDAVAALKNTYDVVYLKVAKPSNAYL--------------SDSYAPPDITTSYSQH 264
+ A+ LK + + V +P +L SD P Q
Sbjct: 87 NATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQG 146
Query: 265 LDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK---------------------DLLGEED 303
+ SS G + P R L +D
Sbjct: 147 RGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQD 206
Query: 304 IPREPRRIVI--HRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 361
+ +P + V+ R S G + G IFI I G A L++GD IL +NG
Sbjct: 207 VQMKPVKSVLVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQING 261
Query: 362 VDLRNAS 368
V +N S
Sbjct: 262 VSSQNLS 268
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 6/77 (7%)
Query: 71 GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAA 130
G G +I+GG D P S+ ++ ++PGG A +GRL+ D I+ VN V + T + A
Sbjct: 40 GFGIAISGGRDRP----GGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFA 93
Query: 131 VEALKEAGSIVRLYVMR 147
++ LK + + V R
Sbjct: 94 IQILKTCTKMANITVKR 110
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 12/84 (14%)
Query: 304 IPREPRRIVIHRGSTGLGFNIVGGED--GEGIFISFILAGGPADLSGELRKGDQILSVNG 361
+ ++PRR G G I GG D G + +S ++ GGPA+ G L+ GD I+ VNG
Sbjct: 33 LSKDPRR--------GFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNG 82
Query: 362 VDLRNASHEQAAIALKNAGQTVTI 385
V + NA+ A LK + I
Sbjct: 83 VSMENATSAFAIQILKTCTKMANI 106
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 125 bits (314), Expect = 1e-28
Identities = 158/628 (25%), Positives = 253/628 (40%), Gaps = 163/628 (25%)
Query: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
+ I+V ++ G A KDG L GD IL +N E++ DA ++ + + L V +
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 244 SNAYLSD---------------------SYAPPDITTSYSQH----LDNEISHSSYLGTD 278
S L + S++P + YS + ++ D
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
Query: 279 YPTAM-----TPTSPRRYSPVAKDLLGEEDIPREPR------------------------ 309
P+ + TPT + +A ++ E + +EPR
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETN--KEPRYQEDPPAPQPKAAPRTFLRPSPED 502
Query: 310 --------RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 361
++V + +G + GG D GIF++ I G A+ G L++GDQIL VN
Sbjct: 503 EAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNT 560
Query: 362 VDLRNASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 419
D R E A + L G+ VTI+AQ + + Y A G G +
Sbjct: 561 QDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA-------------CGRGDS- 606
Query: 420 LRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSD 476
F+IR+ F+ +K Q+L+F G+V V+D + W A R+ ++
Sbjct: 607 --------FFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNE 653
Query: 477 SETDDIGFIPSKRRVER--------REWSRLKAKDW---GSSSG-----SQGRED--SVL 518
E G IP+K R E+ R+ + +A W G SG + RED +V+
Sbjct: 654 LEK---GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVV 710
Query: 519 S-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE 571
S YE V E + RP+++ GP D A + L +E PD F + T PK
Sbjct: 711 SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK---- 763
Query: 572 IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANA 631
+AG S + +VR++ EQ KH +LDV+ A
Sbjct: 764 -------------------------DAGSEKS-TGVVRLNTVRQIIEQDKHALLDVTPKA 797
Query: 632 VRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATKLEQEFTECFSAI 688
V L PI IF P S + V + +R+ + + +RK FD+A KL++ F+A
Sbjct: 798 VDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTAT 857
Query: 689 VEGDSFEEI-YHKVKRVIEDLSGPYIWV 715
+ +S + + +K I+ G +WV
Sbjct: 858 INLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 66.6 bits (161), Expect = 8e-11
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 7/114 (6%)
Query: 36 PPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DPSIFI 93
PP + L APG E E +TL++ + G G +++GG DNPH + + SI I
Sbjct: 10 PPRRELSGWLRAPGM---EELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVI 66
Query: 94 TKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
+ ++PGG A DG L+ ND ++ VN + +V HS AV+ L+++G + + V R
Sbjct: 67 SDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 165 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHE 223
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +EDV+H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 224 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 257
AV L+ + V + V +P ++ A P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 300 GEEDIPREPRRIVIHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 351
G E++ E + + + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
Query: 352 KGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
+ D+++ VNG + + H A L+ +G+ I+ +
Sbjct: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 40.0 bits (92), Expect = 0.008
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 12/88 (13%)
Query: 146 MRRKPPAEKVM--EIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 201
+R P E + K+++ KG +G +AGG D I+V I EG +A ++G
Sbjct: 496 LRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG 548
Query: 202 RLQIGDKILAVNSVGLEDVMHEDAVAAL 229
LQ GD+IL VN+ ++ EDAV L
Sbjct: 549 -LQEGDQILKVNTQDFRGLVREDAVLYL 575
Score = 33.5 bits (75), Expect = 0.71
Identities = 40/143 (27%), Positives = 61/143 (42%), Gaps = 26/143 (18%)
Query: 8 TTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLER 67
T K+ RYQ++ PP P +P + + Y T+ + ++
Sbjct: 473 TNKEPRYQED--PPA-------PQPKAAPRTFLRPSPEDEAIYGPNTK------MVRFKK 517
Query: 68 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
G+S +G +AGG +D IF+ I G +A Q+G L+ D IL VN D R +
Sbjct: 518 GDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVR 568
Query: 128 SAAVEALKE--AGSIVRLYVMRR 148
AV L E G +V + R
Sbjct: 569 EDAVLYLLEIPKGEMVTILAQSR 591
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 125 bits (314), Expect = 1e-28
Identities = 158/628 (25%), Positives = 253/628 (40%), Gaps = 163/628 (25%)
Query: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
+ I+V ++ G A KDG L GD IL +N E++ DA ++ + + L V +
Sbjct: 325 SQIFVKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRD 384
Query: 244 SNAYLSD---------------------SYAPPDITTSYSQH----LDNEISHSSYLGTD 278
S L + S++P + YS + ++ D
Sbjct: 385 SQQTLINIPSLNDSDSEIEDISEIESNRSFSPEERRHQYSDYDYHSSSEKLKERPSSRED 444
Query: 279 YPTAM-----TPTSPRRYSPVAKDLLGEEDIPREPR------------------------ 309
P+ + TPT + +A ++ E + +EPR
Sbjct: 445 TPSRLSRMGATPTPFKSTGDIAGTVVPETN--KEPRYQEDPPAPQPKAAPRTFLRPSPED 502
Query: 310 --------RIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNG 361
++V + +G + GG D GIF++ I G A+ G L++GDQIL VN
Sbjct: 503 EAIYGPNTKMVRFKKGDSVGLRLAGGND-VGIFVAGIQEGTSAEQEG-LQEGDQILKVNT 560
Query: 362 VDLRNASHEQAAIALKNA--GQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTAS 419
D R E A + L G+ VTI+AQ + + Y A G G +
Sbjct: 561 QDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYRDILA-------------CGRGDS- 606
Query: 420 LRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEW---WQARRVHSD 476
F+IR+ F+ +K Q+L+F G+V V+D + W A R+ ++
Sbjct: 607 --------FFIRSHFECEKETP-----QSLAFTRGEVFRVVDTLYDGKLGNWLAVRIGNE 653
Query: 477 SETDDIGFIPSKRRVER--------REWSRLKAKDW---GSSSG-----SQGRED--SVL 518
E G IP+K R E+ R+ + +A W G SG + RED +V+
Sbjct: 654 LEK---GLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSREDLTAVV 710
Query: 519 S-------YETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYE 571
S YE V E + RP+++ GP D A + L +E PD F + T PK
Sbjct: 711 SVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTA---KTEPK---- 763
Query: 572 IDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANA 631
+AG S + +VR++ EQ KH +LDV+ A
Sbjct: 764 -------------------------DAGSEKS-TGVVRLNTVRQIIEQDKHALLDVTPKA 797
Query: 632 VRRLQAAHLHPIAIFIRPRSLENVLEINKRI---TEEQARKAFDRATKLEQEFTECFSAI 688
V L PI IF P S + V + +R+ + + +RK FD+A KL++ F+A
Sbjct: 798 VDLLNYTQWFPIVIFFNPDSRQGVKTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTAT 857
Query: 689 VEGDSFEEI-YHKVKRVIEDLSGPYIWV 715
+ +S + + +K I+ G +WV
Sbjct: 858 INLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 66.6 bits (161), Expect = 8e-11
Identities = 41/114 (35%), Positives = 65/114 (57%), Gaps = 7/114 (6%)
Query: 36 PPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNS-GLGFSIAGGTDNPHIGD-DPSIFI 93
PP + L APG E E +TL++ + G G +++GG DNPH + + SI I
Sbjct: 10 PPRRELSGWLRAPGM---EELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVI 66
Query: 94 TKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
+ ++PGG A DG L+ ND ++ VN + +V HS AV+ L+++G + + V R
Sbjct: 67 SDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKR 118
Score = 58.2 bits (139), Expect = 3e-08
Identities = 31/94 (32%), Positives = 52/94 (55%), Gaps = 3/94 (3%)
Query: 165 KGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHE 223
+G G +++GG N H G+ SI ++ ++ GG A DG LQ D+++ VN +EDV+H
Sbjct: 42 RGFGIAVSGGRDNPHFENGETSIVISDVLPGGPA--DGLLQENDRVVMVNGTPMEDVLHS 99
Query: 224 DAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDI 257
AV L+ + V + V +P ++ A P +
Sbjct: 100 FAVQQLRKSGKVAAIVVKRPRKVQVAALQASPPL 133
Score = 46.2 bits (108), Expect = 1e-04
Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)
Query: 300 GEEDIPREPRRIVIHRGST-GLGFNIVGGED------GE-GIFISFILAGGPADLSGELR 351
G E++ E + + + S G G + GG D GE I IS +L GGPAD G L+
Sbjct: 23 GMEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPAD--GLLQ 80
Query: 352 KGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQ 388
+ D+++ VNG + + H A L+ +G+ I+ +
Sbjct: 81 ENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVK 117
Score = 40.0 bits (92), Expect = 0.008
Identities = 31/88 (35%), Positives = 46/88 (52%), Gaps = 12/88 (13%)
Query: 146 MRRKPPAEKVM--EIKLIKGPKG--LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDG 201
+R P E + K+++ KG +G +AGG D I+V I EG +A ++G
Sbjct: 496 LRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGG-------NDVGIFVAGIQEGTSAEQEG 548
Query: 202 RLQIGDKILAVNSVGLEDVMHEDAVAAL 229
LQ GD+IL VN+ ++ EDAV L
Sbjct: 549 -LQEGDQILKVNTQDFRGLVREDAVLYL 575
Score = 33.5 bits (75), Expect = 0.71
Identities = 40/143 (27%), Positives = 61/143 (42%), Gaps = 26/143 (18%)
Query: 8 TTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLER 67
T K+ RYQ++ PP P +P + + Y T+ + ++
Sbjct: 473 TNKEPRYQED--PPA-------PQPKAAPRTFLRPSPEDEAIYGPNTK------MVRFKK 517
Query: 68 GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTH 127
G+S +G +AGG +D IF+ I G +A Q+G L+ D IL VN D R +
Sbjct: 518 GDS-VGLRLAGG-------NDVGIFVAGIQEGTSAEQEG-LQEGDQILKVNTQDFRGLVR 568
Query: 128 SAAVEALKE--AGSIVRLYVMRR 148
AV L E G +V + R
Sbjct: 569 EDAVLYLLEIPKGEMVTILAQSR 591
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 117 bits (292), Expect = 5e-26
Identities = 62/201 (30%), Positives = 110/201 (54%), Gaps = 16/201 (7%)
Query: 532 RPIIILGPTKDRAND---DLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEK 588
R I+++GP+ N+ L+ P F S VPHTTR K+ YE++GR+YH+VS +E E
Sbjct: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS-KETFEN 486
Query: 589 DIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIR 648
I +H+ +E G+Y HLYGTSV +V+ V +GK C++D+ ++ ++ L P IFI+
Sbjct: 487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIK 546
Query: 649 PRSLENVLE------------INKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEE 696
P ++ + + ++ + +E ++ + A ++E +F + F ++ DS +
Sbjct: 547 PSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHD 606
Query: 697 IYHKVKRVIEDLSGPYIWVPA 717
++ I+ WVPA
Sbjct: 607 ACAQLLSAIQKAQEEPQWVPA 627
Score = 63.9 bits (154), Expect = 5e-10
Identities = 57/206 (27%), Positives = 95/206 (46%), Gaps = 38/206 (18%)
Query: 302 EDIPR--EPRRIV-IHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILS 358
++IP E RIV + + LG I E I ++ I+ GG A+ SG L GD+++
Sbjct: 143 DNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVE 202
Query: 359 VNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTA 418
VNGV + EQ L + T+ K+ + + +NS
Sbjct: 203 VNGVSVEGLDPEQVIHILAMSRGTIMF--------------KVVPVSDPPVNS------- 241
Query: 419 SLRSNPKRGFYIRALFDY--DKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSD 476
++ Y+RA+ +Y + D + L F+ GD+L ++D +D WWQAR++ SD
Sbjct: 242 ------QQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKI-SD 294
Query: 477 SETDDIGFIPSKRRVERRE----WSR 498
T G +PS ++R++ WS+
Sbjct: 295 PAT-CAGLVPSNHLLKRKQREFWWSQ 319
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/97 (32%), Positives = 48/97 (49%), Gaps = 7/97 (7%)
Query: 150 PPAEKVMEIK-LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208
P +E+ M I L+K + LG +I + GD I V +II GG A + G L GDK
Sbjct: 146 PESEEAMRIVCLVKNQQPLGATIK----RHEMTGD--ILVARIIHGGLAERSGLLYAGDK 199
Query: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSN 245
++ VN V +E + E + L + + KV S+
Sbjct: 200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSD 236
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,477,831
Number of Sequences: 37866
Number of extensions: 1329994
Number of successful extensions: 4797
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 137
Number of HSP's that attempted gapping in prelim test: 3585
Number of HSP's gapped (non-prelim): 882
length of query: 721
length of database: 18,247,518
effective HSP length: 110
effective length of query: 611
effective length of database: 14,082,258
effective search space: 8604259638
effective search space used: 8604259638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.