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Search of human proteins with 187607085
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187607085 ligand of numb-protein X 1 isoform a [Homo
sapiens]
(728 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 1490 0.0
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens] 1217 0.0
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 645 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 209 6e-54
gi|112382257 InaD-like [Homo sapiens] 154 3e-37
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 111 2e-24
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 103 7e-22
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 103 7e-22
gi|45827729 scribble isoform b [Homo sapiens] 101 3e-21
gi|45827731 scribble isoform a [Homo sapiens] 101 3e-21
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 98 3e-20
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 98 3e-20
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 95 3e-19
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 92 2e-18
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 92 2e-18
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 84 6e-16
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 84 6e-16
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 82 1e-15
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 81 4e-15
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 80 9e-15
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 80 9e-15
gi|87196343 PDZ domain containing 2 [Homo sapiens] 79 1e-14
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 77 4e-14
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 77 4e-14
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 77 6e-14
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 75 2e-13
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 74 4e-13
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 71 3e-12
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 71 3e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 69 1e-11
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 1490 bits (3857), Expect = 0.0
Identities = 728/728 (100%), Positives = 728/728 (100%)
Query: 1 MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTY 60
MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTY
Sbjct: 1 MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTY 60
Query: 61 CTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDL 120
CTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDL
Sbjct: 61 CTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDL 120
Query: 121 EHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLD 180
EHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLD
Sbjct: 121 EHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLD 180
Query: 181 NPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAV 240
NPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAV
Sbjct: 181 NPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAV 240
Query: 241 ANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH 300
ANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH
Sbjct: 241 ANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH 300
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK
Sbjct: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
Query: 361 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH 420
FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH
Sbjct: 361 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH 420
Query: 421 GQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN 480
GQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN
Sbjct: 421 GQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN 480
Query: 481 GSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISV 540
GSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISV
Sbjct: 481 GSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISV 540
Query: 541 EPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQED 600
EPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQED
Sbjct: 541 EPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQED 600
Query: 601 CSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEY 660
CSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEY
Sbjct: 601 CSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEY 660
Query: 661 NGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
NGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI
Sbjct: 661 NGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
Query: 721 VSWPGTFL 728
VSWPGTFL
Sbjct: 721 VSWPGTFL 728
>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
Length = 632
Score = 1217 bits (3148), Expect = 0.0
Identities = 605/628 (96%), Positives = 610/628 (97%)
Query: 101 LLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAP 160
LL+ P+ + +L + CKGASHYGLTKDRKRRSQDGCPDGCASLTATAP
Sbjct: 5 LLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLTATAP 64
Query: 161 SPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRS 220
SPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRS
Sbjct: 65 SPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRS 124
Query: 221 FKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRV 280
FKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRV
Sbjct: 125 FKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRV 184
Query: 281 DPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340
DPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA
Sbjct: 185 DPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 244
Query: 341 VRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRK 400
VRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRK
Sbjct: 245 VRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRK 304
Query: 401 VDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 460
VDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV
Sbjct: 305 VDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 364
Query: 461 SRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGM 520
SRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGM
Sbjct: 365 SRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGM 424
Query: 521 TVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR 580
TVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR
Sbjct: 425 TVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKR 484
Query: 581 TSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIV 640
TSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIV
Sbjct: 485 TSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIV 544
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM
Sbjct: 545 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 604
Query: 701 IHACLARLLKELKGRITLTIVSWPGTFL 728
IHACLARLLKELKGRITLTIVSWPGTFL
Sbjct: 605 IHACLARLLKELKGRITLTIVSWPGTFL 632
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 645 bits (1664), Expect = 0.0
Identities = 352/730 (48%), Positives = 468/730 (64%), Gaps = 61/730 (8%)
Query: 6 SANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCL 65
S++ PLC CGQ H ENH Y+Y EVDDDL+CHICLQ LL PLDTPCGHT+C CL
Sbjct: 15 SSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCL 74
Query: 66 TNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQ 125
NFL EKDFCP+DRK L + CKKSSILV+KLL+KLLV CPF C V+QRCDLE H +
Sbjct: 75 RNFLQEKDFCPLDRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLK 134
Query: 126 TSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYV 185
C GASH + +R++ S+ T + + +E G P +
Sbjct: 135 NRCPGASHRRVALERRKTSR-----------------------TQAEIENENG---PTLL 168
Query: 186 SSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHAD 245
A P + +G A P ER + L + N A
Sbjct: 169 DPAGTLSPEADCLGTG------AVPVERHLTSAS-----------LSTWSEEPGLDNPAF 211
Query: 246 QGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQH 305
+ ++ T P +P+GEIT+I+I+R +P L I +VGG+ETPL++I+IQ
Sbjct: 212 EESAGADTTQQPLS-------LPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQE 264
Query: 306 IYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRN 365
+YRDGVIARDGRLL GD IL+VN +ISNV HNYA +L QPC L LTV+RE++F +R
Sbjct: 265 VYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVLRERRFGNRA 324
Query: 366 NGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEE 425
+ + D+ PR++ F V L+K EQLGIKLVR+ DEPGVFI ++L+GG+A + G+L
Sbjct: 325 HNHS-DSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSS 383
Query: 426 NDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSP 485
NDRVLAINGHDL+YG+PE AA +IQAS RV+L ++R + + + +EAG +S+ S
Sbjct: 384 NDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHH 443
Query: 486 GPG---ERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 542
P R ++ K L +TC EK + ++K+P ESLGMTVAGG + +LPI+V SV P
Sbjct: 444 TPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPP 503
Query: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSS--IVLKALEVK--EYEPQ 598
G ++RDGRIK GD+LLN++G++LT +S SEAVA+LK +++S + LKALEV+ E Q
Sbjct: 504 HGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKALEVQIVEEATQ 563
Query: 599 EDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYE 658
P+ N A WSPSWVMWL LP L++C DIVLRR+ GS GF IVGGYE
Sbjct: 564 NAEEQPSTFSENEYDA---SWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYE 620
Query: 659 EYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
E + N+PFFIK+IV GTPAY DGR++CGD+++AVNG ST GM H+ L +LKE + ++TL
Sbjct: 621 ENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTL 680
Query: 719 TIVSWPGTFL 728
T++ WPG+ +
Sbjct: 681 TVICWPGSLV 690
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 209 bits (533), Expect = 6e-54
Identities = 152/488 (31%), Positives = 248/488 (50%), Gaps = 64/488 (13%)
Query: 250 NSENTTAPEVF---PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHI 306
N+ ++ P +F P +IP E T+I+I++ LSI VGGS+T L III +
Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCE-TTIEISKGRTGLGLSI--VGGSDTLLGAIIIHEV 1659
Query: 307 YRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN 366
Y +G +DGRL GD IL+VNG+D+ H+ A+ +LRQ Q + LT+ R+
Sbjct: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRD-------- 1711
Query: 367 GQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEN 426
+AP D+ + L K P + LG+ +V K ++ GVF+ +++ GG+A G+L +
Sbjct: 1712 -EAPYKEEEVCDTLTIELQK-KPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQG 1769
Query: 427 DRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG 486
D++L +NG D+R + E+ A L++ SE + S F +G +++ S
Sbjct: 1770 DQILMVNGEDVRNATQEAVAALLKVSEGSL-----------SSFTFPLSGSSTSESL--- 1815
Query: 487 PGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVI 546
E S+ L I + V ++K P +SLG+++AGG D+PI++ + P GV
Sbjct: 1816 --ESSSKKNALASEIQ-GLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVA 1872
Query: 547 SRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKA-----LEVKEYEPQEDC 601
++ +++ GD ++ + G ++ ++AV LLK S SI ++ + V QE
Sbjct: 1873 AQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPA 1932
Query: 602 SSPAALDS-------NHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV 654
SS + ++ PP CK I L R G LGF IV
Sbjct: 1933 SSSLSFTGLTSSSIFQDDLGPP------------------QCKSITLERGPDG-LGFSIV 1973
Query: 655 GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKG 714
GGY +G+ P ++K++ A DGR++ GD ++AVNG+S G+ H +LK KG
Sbjct: 1974 GGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKG 2033
Query: 715 RITLTIVS 722
+TL ++S
Sbjct: 2034 TVTLMVLS 2041
Score = 117 bits (294), Expect = 3e-26
Identities = 117/518 (22%), Positives = 199/518 (38%), Gaps = 98/518 (18%)
Query: 250 NSENTTAPEVFPRLYHLIPDGEITSIK-INRVD-PSESLSIRLVGGSETPLVHIIIQHIY 307
NSEN E P + +++S K + ++ P + + + E L +II+ +
Sbjct: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLT 1512
Query: 308 RDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE--------- 358
GV A DGRL GD IL V+ + P + LL+ + LT+ E
Sbjct: 1513 EHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPS 1572
Query: 359 -------QKFRSRNNGQAPDAYRPRDDSFHVILNKSSP---------------------- 389
+K S + P + P +S S+P
Sbjct: 1573 AAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
Query: 390 ---EEQLGIKLVRKVDE--PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPES 444
LG+ +V D + I V + G A + G+L D++L +NG DLR + +
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
Query: 445 AAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCH 504
A ++++ + +RV L + R P C
Sbjct: 1693 AINVLRQTPQRVRLTLYRD------------------------------EAPYKEEEVCD 1722
Query: 505 EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 564
+ +QK PG+ LG+++ G + D ++V + GG+ DGR+ GD +L V+G
Sbjct: 1723 TLTIELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
Query: 565 ELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWV 624
++ ++ ALLK + S+ P S+ +L+S+
Sbjct: 1779 DVRNATQEAVAALLKVSEGSLSSFTF------PLSGSSTSESLESSSKKN---------- 1822
Query: 625 MWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIR 684
L + + + +++ SLG I GG G+ P FI + A ++R
Sbjct: 1823 ---ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
Query: 685 CGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 722
GD ++ + G ST GM H LLK G I + +V+
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVA 1917
Score = 94.0 bits (232), Expect = 4e-19
Identities = 85/328 (25%), Positives = 153/328 (46%), Gaps = 38/328 (11%)
Query: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHLVVS 461
E G+F+ + +G VA+R G+L+E D++LAING L + + A ++Q ++ V LV++
Sbjct: 162 ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
Query: 462 RQVRQR--SPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLG 519
R + SP + S P S +P H + + + D G LG
Sbjct: 222 RGSLPQLVSPIV------------SRSPSAASTISAHSNPVHWQHMETIELVND-GSGLG 268
Query: 520 MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579
+ GG + + V ++ PGGV + GR+ +GD +L + +L +S + +L+
Sbjct: 269 FGIIGGKA-----TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
Query: 580 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN-CKD 638
+ + + L E+ ++P AL + +P S +P + + + D
Sbjct: 324 QCGNRVKLMIAR----GAIEERTAPTALGITLSSSPTS--TPELRVDASTQKGEESETFD 377
Query: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPF-----FIKSIVEGTPAYNDGRIRCGDILLAVN 693
+ L +N G LG I G Y G+K F+KSI + + +DGRI+ GD ++AV+
Sbjct: 378 VELTKNVQG-LGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
Query: 694 GRSTSGMIHACLARLLKELKGRITLTIV 721
G + G + +L+ + LT++
Sbjct: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLM 460
Score = 93.6 bits (231), Expect = 6e-19
Identities = 90/362 (24%), Positives = 153/362 (42%), Gaps = 43/362 (11%)
Query: 282 PSESLSIRLVG--GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN-VPHN 338
PS L +VG + I +Q I V RDGRL D IL +NG + + H
Sbjct: 144 PSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
Query: 339 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRP----RDDSFHVILNKSSPEEQLG 394
A+ +L++ + L + R G P P + I S+P
Sbjct: 204 QAISILQKAKDTVQLVIAR---------GSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
Query: 395 IKLVRKVDE-------------PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 441
++ + V++ GV + +L GGVA +HG+L D +L I DL S
Sbjct: 255 METIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
Query: 442 PESAAHLIQASERRVHLVVSR-QVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPT 500
E A +++ RV L+++R + +R+ +S+ + +P ++T K
Sbjct: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
Query: 501 ITCHEKVVNIQKDPGESLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILL 559
E N+Q LG+T+AG ++ + I+V S+ + DGRI+ GD ++
Sbjct: 375 TFDVELTKNVQ-----GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
Query: 560 NVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDW 619
VDG L + +AV +L+ T +++L + + A L S ++ +D
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM-------RRGMKQEAELMSREDVTKDADL 482
Query: 620 SP 621
SP
Sbjct: 483 SP 484
Score = 88.6 bits (218), Expect = 2e-17
Identities = 113/499 (22%), Positives = 199/499 (39%), Gaps = 95/499 (19%)
Query: 270 GEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNG 329
GE+ I++ + L + L G + + + I I +G +DGRL D +L++NG
Sbjct: 1346 GELHMIELEK--GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
Query: 330 MDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSS- 388
+ H A +++ + + +R + ++ +A P + + NK +
Sbjct: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
Query: 389 -----------------------PEEQ--LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQL 423
P++Q LGI + + GV I ++ + GVA G+L
Sbjct: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRL 1523
Query: 424 EENDRVLAINGHDLRYGSP-ESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN-- 480
+ D++LA++ ++ G P E L++ ++ V L + + S + AG S
Sbjct: 1524 KVGDQILAVD-DEIVVGYPIEKFISLLKTAKMTVKLTIHAE-NPDSQAVPSAAGAASGEK 1581
Query: 481 ----------GSWSPGPGERSNTPKPLHPTI------TCH-----EKVVNIQKDPGESLG 519
S SP P NT + P I TC E + I K LG
Sbjct: 1582 KNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKG-RTGLG 1640
Query: 520 MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579
+++ GG+ + I+ + E G +DGR+ GD +L V+G++L + + EA+ +L+
Sbjct: 1641 LSIVGGSDTLLGAIIIHEVYEE--GAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLR 1698
Query: 580 RTSSSIVLKAL-EVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKD 638
+T + L + Y+ +E C +
Sbjct: 1699 QTPQRVRLTLYRDEAPYKEEEVCDT---------------------------------LT 1725
Query: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 698
I L++ LG IVG + F+ IV+G A DGR+ GD +L VNG
Sbjct: 1726 IELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
Query: 699 GMIHACLARLLKELKGRIT 717
+A LLK +G ++
Sbjct: 1782 NATQEAVAALLKVSEGSLS 1800
Score = 72.8 bits (177), Expect = 1e-12
Identities = 87/362 (24%), Positives = 143/362 (39%), Gaps = 47/362 (12%)
Query: 393 LGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 450
LG+ L D VFI + G A + G+L+ D +L ING L S ++A+ +I+
Sbjct: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
Query: 451 ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP-KPLHPTITCHEKVVN 509
+ +V ++ R+ D + + P P N K PT+T + V+
Sbjct: 1420 CAPSKVKIIFI-----RNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
Query: 510 IQ-----------KDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDIL 558
+ KD G LG+ + S + + + S+ GV + DGR+K GD +
Sbjct: 1475 LSSFKNVQHLELPKDQG-GLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQI 1529
Query: 559 LNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAAL-----DSNHNM 613
L VD + + ++LLK T+ V + + + Q S+ A +S+ ++
Sbjct: 1530 LAVDDEIVVGYPIEKFISLLK-TAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL 1588
Query: 614 APPSDWSPSWVMWLELPR---------------CLYNCKDIVLRRNTAGSLGFCIVGGYE 658
P SP R + C+ + LG IVGG +
Sbjct: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
Query: 659 EYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
G I + E A DGR+ GD +L VNG H +L++ R+ L
Sbjct: 1649 TLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
Query: 719 TI 720
T+
Sbjct: 1707 TL 1708
Score = 70.1 bits (170), Expect = 7e-12
Identities = 55/220 (25%), Positives = 98/220 (44%), Gaps = 23/220 (10%)
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
H +V + K P LG +V G S +L I+V ++ G V RDGR+K D +L ++G
Sbjct: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
Query: 564 VELTE-VSRSEAVALLKRTSSSI--VLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWS 620
L + ++ +A+++L++ ++ V+ + + SP+A + + P W
Sbjct: 194 QALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQ 253
Query: 621 PSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYND 680
+ L N LGF I+GG +K+I+ G A
Sbjct: 254 HMETIELV---------------NDGSGLGFGIIGGKA-----TGVIVKTILPGGVADQH 293
Query: 681 GRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
GR+ GD +L + +GM +A++L++ R+ L I
Sbjct: 294 GRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
Score = 65.1 bits (157), Expect = 2e-10
Identities = 103/537 (19%), Positives = 205/537 (38%), Gaps = 108/537 (20%)
Query: 277 INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP 336
I V+ L ++GG T +I++ I GV + GRL GD ILK+ D++ +
Sbjct: 258 IELVNDGSGLGFGIIGGKATG---VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
Query: 337 HNYAVRLLRQPCQVLWLTVMR---EQKFRSRNNG---------------QAPDAYRPRDD 378
++LRQ + L + R E++ G A +
Sbjct: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
Query: 379 SFHVILNKSSPEEQLGIKLV-----RKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAIN 433
+F V L K+ + LGI + +K++ G+F+ ++ G+++ D+++A++
Sbjct: 375 TFDVELTKNV--QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
Query: 434 GHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG------- 486
G +L+ + + A +++ + + V L + R+ ++ ++ + SP
Sbjct: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKE 492
Query: 487 ------------------PGERSNTP-------------KPLHPTITCHEKVVNIQKD-- 513
P E P K +T ++++ I +
Sbjct: 493 NYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIV 552
Query: 514 --------PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVE 565
LG+++ H ++ SV P G + G++ +GD LL V+G+
Sbjct: 553 VAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
Query: 566 LTEVSRSEAVALLKRTSSSIV---------------LKALEVKEYE----PQEDCSSPAA 606
L + + V +LK + L +L++ + E P D
Sbjct: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
Query: 607 LDSNHNMAPPSDWSPSWVMWLELPRCLYNC--KDIVLRRNTAGSLGFCIVGGYEEYN-GN 663
+ + ++ P ++ + I L + + G LGF I+ + + +
Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKG-LGFSILDYQDPIDPAS 725
Query: 664 KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
I+S+V G A DGR+ GD L+ VN + ++ L ++ LKG + T+
Sbjct: 726 TVIIIRSLVPGGIAEKDGRLLPGDRLMFVN---DVNLENSSLEEAVEALKGAPSGTV 779
Score = 60.1 bits (144), Expect = 7e-09
Identities = 63/241 (26%), Positives = 105/241 (43%), Gaps = 28/241 (11%)
Query: 505 EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 564
E+ +NI K SLGMTV+ L + V S+ GG ISRDGRI GD +L+++
Sbjct: 1006 ERTINIAKG-NSSLGMTVSANKD----GLGMIVRSIIHGGAISRDGRIAIGDCILSINEE 1060
Query: 565 ELTEVSRSEAVALLKRTS--------SSIVLKALEVKEYEPQEDCSSPAALD-----SNH 611
V+ ++A A+L+R S + + + LE + + ALD +
Sbjct: 1061 STISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGR 1120
Query: 612 NMAPPSDWSPSWVMWLELPRCLYN----CKDIVLRRNTAGSLGFCIVG----GYEEYNGN 663
++ + EL Y+ + + L R + SLG IVG G NG
Sbjct: 1121 DIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGE 1180
Query: 664 --KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 721
+ FIK ++E +PA +G ++ GD ++ V+G H +++ + +
Sbjct: 1181 VMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
Query: 722 S 722
S
Sbjct: 1241 S 1241
Score = 59.3 bits (142), Expect = 1e-08
Identities = 83/431 (19%), Positives = 160/431 (37%), Gaps = 90/431 (20%)
Query: 378 DSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHD- 436
+SF +N + LG+ + D G+ + +++ GG R G++ D +L+IN
Sbjct: 1003 ESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
Query: 437 LRYGSPESAA----HLIQASERRVHLVVSRQVRQRSPDIFQEAG--------WNSNGSWS 484
+ + ++ A H + + ++ V + + + + Q++G + G
Sbjct: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
Query: 485 P-------GPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGG------ASHREW 531
P G GE S + + V + ++P +SLG+++ GG S+ E
Sbjct: 1123 PELPEREEGEGEESELQNTAYSNWN-QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
Query: 532 DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL---- 587
I++ V ++G +K GD ++ VDG++L + S +AV +++ + +V
Sbjct: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS 1241
Query: 588 --------------------------------------KALEVKEYEPQED--CSSP--- 604
KA E EP++ CS P
Sbjct: 1242 IINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPP 1301
Query: 605 ----AALDSNHNMAPPS----------DWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLG 650
A + S+H + S ++ SW E L ++ LG
Sbjct: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361
Query: 651 FCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLK 710
+ G + FI I A DGR++ D LL +NG+ G H + ++K
Sbjct: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
Query: 711 ELKGRITLTIV 721
++ + +
Sbjct: 1420 CAPSKVKIIFI 1430
Score = 57.0 bits (136), Expect = 6e-08
Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 13/217 (5%)
Query: 510 IQKDPGES-LGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTE 568
I+ + G S LG+++AG + ++++ ++P G +DGR++ D LL ++G L
Sbjct: 1351 IELEKGHSGLGLSLAGNKDRSR--MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
Query: 569 VSRSEAVALLKRTSSSIVLKALEVKEYEPQ-EDCSSPAA--LDSNHNMAPPSDWSPSWVM 625
S A +++K S + + + K+ Q C A L SN + P+ V
Sbjct: 1409 RSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPT-VT 1467
Query: 626 WLELPRCLYNCKDI--VLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683
+ L + K++ + G LG I E + IKS+ E A DGR+
Sbjct: 1468 TSDAAVDLSSFKNVQHLELPKDQGGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRL 1523
Query: 684 RCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
+ GD +LAV+ G LLK K + LTI
Sbjct: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
Score = 49.3 bits (116), Expect = 1e-05
Identities = 26/74 (35%), Positives = 42/74 (56%), Gaps = 8/74 (10%)
Query: 281 DPSESLSIRLVGG--------SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 332
+PS+SL I +VGG + + I I+H+ D ++G L PGD I++V+GMD+
Sbjct: 1157 EPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
Query: 333 SNVPHNYAVRLLRQ 346
+ H AV +R+
Sbjct: 1217 RDASHEQAVEAIRK 1230
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 51/210 (24%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVN------------------------GMDISNVP 336
+I++ I G I+RDGR+ GD IL +N + I+ VP
Sbjct: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVP 1090
Query: 337 ----HNYAVRLLRQPCQVLWLTVMREQKFRS------RNNGQAPD------AYRPRDDSF 380
+ + L +Q +V+ L + R R G+ + AY +
Sbjct: 1091 AEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR 1150
Query: 381 HVILNKSSPEEQLGIKLV--RKVDEP--------GVFIFNVLDGGVAYRHGQLEENDRVL 430
V L + P + LGI +V R + G+FI +VL+ A ++G L+ DR++
Sbjct: 1151 RVELWRE-PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
Query: 431 AINGHDLRYGSPESAAHLIQASERRVHLVV 460
++G DLR S E A I+ + V +V
Sbjct: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
Score = 37.4 bits (85), Expect = 0.050
Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 5/88 (5%)
Query: 271 EITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGM 330
EI +++ + L I L E + H I+ + +G + G+L GD +L+VNG+
Sbjct: 550 EIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
Query: 331 DISNVPHNYAVRLLRQ-PCQVLWLTVMR 357
+ H V +L++ P +V + R
Sbjct: 606 TLLGENHQDVVNILKELPIEVTMVCCRR 633
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 154 bits (389), Expect = 3e-37
Identities = 126/455 (27%), Positives = 218/455 (47%), Gaps = 45/455 (9%)
Query: 157 ATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTI 216
A P P S++ S + D+ G + +SS EDG V+ G + F+ +
Sbjct: 1329 AVTPFPVPSSSP--SSIEDQSGTEP---ISSEEDGS-----VEVGIKQLPESESFKLAVS 1378
Query: 217 RSRSFKKINRALSVLRRTKSGSAVANHA-DQGRENSENTTAP-EVFPRLYHLIPDGEITS 274
+ + K + + A + H+ D AP V P ++P E+
Sbjct: 1379 QMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI- 1437
Query: 275 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334
I+I++ L + +VGG +TPL I+I +Y +G ARDGRL GD IL+VNG+D+ N
Sbjct: 1438 IEISK--GRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
Query: 335 VPHNYAVRLLRQPCQVLWLTVMR-EQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQL 393
H A+ LRQ Q + L V R E +R N + F V L K + L
Sbjct: 1496 SSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEI----------FPVDLQKKA-GRGL 1544
Query: 394 GIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 453
G+ +V K + GVFI +++ GG A G+L + D++L++NG D+R S E+ A +++ ++
Sbjct: 1545 GLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQ 1604
Query: 454 RRVHLVV----------SRQVRQRSPDIFQEAGWNSNGSWSP--------GPGERSNTPK 495
V L + +R Q S Q A + + S++P +R + P
Sbjct: 1605 GLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPS 1664
Query: 496 PLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTG 555
+ + V I ++ ++LG+++AGG D+P+++ ++ GV +R ++K G
Sbjct: 1665 QKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVG 1724
Query: 556 DILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL 590
D +++++G L +S ++ V LLK I+L+ +
Sbjct: 1725 DRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/335 (26%), Positives = 152/335 (45%), Gaps = 56/335 (16%)
Query: 400 KVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHL 458
KVD +F+ +V G VA R +L+END++LAIN L S + A L+Q + + L
Sbjct: 159 KVD---IFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRL 215
Query: 459 VVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLH----PTITC--HEKVVNIQK 512
+V+R+ +S+T L+ P C H + V +
Sbjct: 216 IVAREPVHT----------------------KSSTSSSLNDTTLPETVCWGHVEEVELIN 253
Query: 513 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 572
D G LG + GG + + V ++ PGG+ RDGR++TGD +L + G + ++
Sbjct: 254 D-GSGLGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSE 307
Query: 573 EAVALLKRTSSSI-VLKALEVK---EYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLE 628
+ +L+ +S+ +L A + P + P AL + + P SD S
Sbjct: 308 QVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS-------- 359
Query: 629 LPRCLYNCKDIVLRRNTAGSLGFCIVG--GYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686
L+ ++ L R SLG IVG G ++KSI+ G+ AY++G I+
Sbjct: 360 ----LFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
Query: 687 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 721
D ++AV+G + G + + +L+ + LT+V
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV 450
Score = 95.1 bits (235), Expect = 2e-19
Identities = 91/360 (25%), Positives = 151/360 (41%), Gaps = 54/360 (15%)
Query: 382 VILNKSSPEEQLGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRY 439
+I+ S LG+ +V D P + I V + G A R G+L D++L +NG DLR
Sbjct: 1436 MIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRN 1495
Query: 440 GSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP 499
S E A ++ + ++V LVV R EA + + P
Sbjct: 1496 SSHEEAITALRQTPQKVRLVVYRD----------EAHYRDEENLEIFP------------ 1533
Query: 500 TITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILL 559
V++QK G LG+++ G + +++ + GG DGR+ GD +L
Sbjct: 1534 --------VDLQKKAGRGLGLSIVGKRNGSG----VFISDIVKGGAADLDGRLIQGDQIL 1581
Query: 560 NVDGVELTEVSRSEAVALLKRTSSSIVLKA--LEVKEYEPQEDCS--SPAALDSNHNMAP 615
+V+G ++ S+ +LK + L+ L + S S + S H+
Sbjct: 1582 SVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCH 1641
Query: 616 PSDWSPSWVMWLEL--------PRCLYNCKD-----IVLRRNTAGSLGFCIVGGYEEYNG 662
PS ++P L P + D + + R + +LG I GG G
Sbjct: 1642 PS-FAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLG 1700
Query: 663 NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 722
+ P FI I A +++ GD ++++NG+ G+ HA + LLK GRI L +V+
Sbjct: 1701 DIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760
Score = 80.1 bits (196), Expect = 7e-15
Identities = 88/335 (26%), Positives = 141/335 (42%), Gaps = 43/335 (12%)
Query: 299 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS-NVPHNYAVRLLRQPCQVLWLTVMR 357
V I ++ + V RD RL D IL +N + N+ H A+ LL+Q L L V R
Sbjct: 160 VDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Query: 358 EQKF-RSRNNGQAPDAYRPRDDSF-HV----ILNKSSPEEQLGIKLVRKVDEPGVFIFNV 411
E +S + D P + HV ++N S LG +V GV + +
Sbjct: 220 EPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSG---LGFGIVGGKTS-GVVVRTI 275
Query: 412 LDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQ------VR 465
+ GG+A R G+L+ D +L I G +++ + E A +++ V ++V+R V
Sbjct: 276 VPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVT 335
Query: 466 QRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG- 524
+P A S GPG S+ + + V + + G+SLG+ + G
Sbjct: 336 PPAPAALPVA---LPTVASKGPGSDSSLFETYN---------VELVRKDGQSLGIRIVGY 383
Query: 525 -GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSS 583
G SH IYV S+ PG +G I+ D ++ VDGV + + + V +L+
Sbjct: 384 VGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQ 443
Query: 584 SIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 618
+ L + K S + PPSD
Sbjct: 444 VVHLTLVRRK------------TSSSTSPLEPPSD 466
Score = 70.5 bits (171), Expect = 5e-12
Identities = 58/218 (26%), Positives = 100/218 (45%), Gaps = 25/218 (11%)
Query: 508 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 567
++I++ LG +V S + I+V V+PG V RD R+K D +L ++ L
Sbjct: 135 IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194
Query: 568 E-VSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
+ +S +A+ALL++T+ S+ L + EP SS ++ ++ + P V W
Sbjct: 195 QNISHQQAIALLQQTTGSLRL----IVAREPVHTKSSTSSSLNDTTL-------PETVCW 243
Query: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686
+ V N LGF IVGG +++IV G A DGR++ G
Sbjct: 244 GHVEE--------VELINDGSGLGFGIVGGK-----TSGVVVRTIVPGGLADRDGRLQTG 290
Query: 687 DILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWP 724
D +L + G + GM +A++L+ + + + P
Sbjct: 291 DHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDP 328
Score = 64.3 bits (155), Expect = 4e-10
Identities = 55/247 (22%), Positives = 111/247 (44%), Gaps = 41/247 (16%)
Query: 276 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 335
++ ++ L +VGG + ++++ I G+ RDGRL GD ILK+ G ++ +
Sbjct: 248 EVELINDGSGLGFGIVGGKTSG---VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGM 304
Query: 336 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYR----------PRDDS-----F 380
++LR + + V R+ AP A P DS +
Sbjct: 305 TSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETY 364
Query: 381 HVILNKSSPEEQLGIKLVRKV------DEPGVFIFNVLDGGVAYRHGQLEENDRVLAING 434
+V L + + LGI++V V + G+++ +++ G AY +G ++ ND+++A++G
Sbjct: 365 NVELVRKDGQS-LGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDG 423
Query: 435 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSP--GPGERSN 492
+++ + +++ + + VHL + R+ ++ S SP P +R
Sbjct: 424 VNIQGFANHDVVEVLRNAGQVVHLTLVRR--------------KTSSSTSPLEPPSDRGT 469
Query: 493 TPKPLHP 499
+PL P
Sbjct: 470 VVEPLKP 476
Score = 58.2 bits (139), Expect = 3e-08
Identities = 65/285 (22%), Positives = 104/285 (36%), Gaps = 68/285 (23%)
Query: 488 GERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGAS------HREWDLPIYVISVE 541
GE TP H ++V I ++P SLG+++ GG + + E I++ V
Sbjct: 1052 GEGEETPNFSH---WGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVL 1108
Query: 542 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 601
+ +KTGD +L V GV+L S SEAV +K + +V + Q
Sbjct: 1109 EDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--------FIVQSLS 1160
Query: 602 SSPAALDSNHNMA-----------------------PPSDWSPSW--------------- 623
S+P + + HN A PP P +
Sbjct: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDA 1220
Query: 624 -------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 676
+ +LP L+ I+ LG + G + F+ I P
Sbjct: 1221 FTDQKIRQRYADLPGELH----IIELEKDKNGLGLSLAGNKD--RSRMSIFVVGINPEGP 1274
Query: 677 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 721
A DGR+R GD LL +N + G H + ++K ++ L +
Sbjct: 1275 AAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI 1319
Score = 51.6 bits (122), Expect = 3e-06
Identities = 59/270 (21%), Positives = 108/270 (40%), Gaps = 47/270 (17%)
Query: 392 QLGIKLVRKVDE-PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 450
Q IK ++ +E G+FI VL+ A + L+ D++L ++G DL+ S A I+
Sbjct: 1087 QTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK 1146
Query: 451 ASERRVHLVVSR--QVRQRSPDIFQEAG---WNSNGSWSPGPGERSNT-PKPL------- 497
+ V +V + P++ +A N N +R T P P+
Sbjct: 1147 NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206
Query: 498 -----------------------HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLP 534
+ + ++ ++KD LG+++AG +
Sbjct: 1207 ALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSR--MS 1263
Query: 535 IYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 594
I+V+ + P G + DGR++ GD LL ++ L S A A++K S + L + ++
Sbjct: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNED 1323
Query: 595 YEPQ-------EDCSSPAALDSNHNMAPPS 617
Q SSP++++ P S
Sbjct: 1324 AVNQMAVTPFPVPSSSPSSIEDQSGTEPIS 1353
Score = 44.7 bits (104), Expect = 3e-04
Identities = 45/174 (25%), Positives = 74/174 (42%), Gaps = 30/174 (17%)
Query: 536 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKAL----- 590
Y+ S+ GG + G ++ D LL V+G++L SR EAV+ LK L
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 591 -EVKEYEPQEDCSSPAALDSNHNMAPPSD---------WSPSWVMWLELPRCLYNCKDIV 640
E EP+ +S + +HNM ++ WSP +++ + +CK
Sbjct: 642 DEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPE----VKIVELVKDCK--- 694
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVN 693
LGF I+ + + + I+S+V A G + GD L++VN
Sbjct: 695 -------GLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Score = 41.6 bits (96), Expect = 0.003
Identities = 52/248 (20%), Positives = 88/248 (35%), Gaps = 67/248 (27%)
Query: 281 DPSESLSIRLVGGSET--------PLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 332
+P+ SL I +VGG L I I+ + D + L GD IL+V+G+D+
Sbjct: 1074 EPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDL 1133
Query: 333 SNVPHNYAVRLLRQPCQVLWLTVMR-------------------------EQKFRSRNNG 367
N H+ AV ++ + V Q+ + + G
Sbjct: 1134 QNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQG 1193
Query: 368 QAPDAYR---------------PRDDSF----------------HVILNKSSPEEQLGIK 396
AP + +D+F H+I + LG+
Sbjct: 1194 TAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHII-ELEKDKNGLGLS 1252
Query: 397 LVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASER 454
L D +F+ + G A G++ D +L IN L S ++A+ +I+ +
Sbjct: 1253 LAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPS 1312
Query: 455 RVHLVVSR 462
+V LV R
Sbjct: 1313 KVKLVFIR 1320
Score = 35.8 bits (81), Expect = 0.14
Identities = 18/45 (40%), Positives = 26/45 (57%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345
I+I+ + DGV R G LLPGD ++ VN + N AV +L+
Sbjct: 714 IVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758
Score = 35.4 bits (80), Expect = 0.19
Identities = 25/85 (29%), Positives = 36/85 (42%), Gaps = 6/85 (7%)
Query: 648 SLGFCIVGGYEEY----NGN--KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 701
SLG IVGG NG K FIK ++E +PA ++ GD +L V+G
Sbjct: 1078 SLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNAS 1137
Query: 702 HACLARLLKELKGRITLTIVSWPGT 726
H+ +K + + S T
Sbjct: 1138 HSEAVEAIKNAGNPVVFIVQSLSST 1162
Score = 33.9 bits (76), Expect = 0.55
Identities = 45/200 (22%), Positives = 71/200 (35%), Gaps = 36/200 (18%)
Query: 407 FIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQ 466
+I +++ GG G L+ D +L +NG L S A ++ LV R++
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 467 RSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG-- 524
+ E T L T H VN ++D L +
Sbjct: 642 DEASV----------------DEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVK 685
Query: 525 -----------GASHREWDLP-------IYVISVEPGGVISRDGRIKTGDILLNVDGVEL 566
G S ++ P I + S+ GV R G + GD L++V+ L
Sbjct: 686 IVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
Query: 567 TEVSRSEAVALLKRTSSSIV 586
S +EAV +LK +V
Sbjct: 746 DNTSLAEAVEILKAVPPGLV 765
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 111 bits (278), Expect = 2e-24
Identities = 102/347 (29%), Positives = 146/347 (42%), Gaps = 71/347 (20%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+PG+FI ++ GG A G+L ND VL +N D+ A ++ + V LVV
Sbjct: 156 DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVR 215
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 521
R RQ P+ E VN+ K P + LG +
Sbjct: 216 R--RQPPPETIME---------------------------------VNLLKGP-KGLGFS 239
Query: 522 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579
+AGG H D IY+ + GG +DGR++ GD LL V+ L +V EAVA LK
Sbjct: 240 IAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLK 299
Query: 580 RTSSSIVLK-----ALEVKE-YEPQEDCSSPAALDSNH---------------------- 611
TS + LK +L + + Y P + S+ AL NH
Sbjct: 300 NTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAP 359
Query: 612 NMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 671
PP+ +SP L + I+L + + G LGF IVGG + + F+ I
Sbjct: 360 PQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTG-LGFNIVGGED----GEGIFVSFI 414
Query: 672 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
+ G PA G +R GD +L+VNG + H A LK +T+
Sbjct: 415 LAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTI 461
Score = 89.7 bits (221), Expect = 8e-18
Identities = 94/357 (26%), Positives = 148/357 (41%), Gaps = 65/357 (18%)
Query: 283 SESLSIRLVGGSETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHN 338
+ L + GG + P V I I I G A DGRL D +L+VN +D+S V H+
Sbjct: 138 NSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHS 197
Query: 339 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLV 398
AV L++ V+ L V R Q P + V L K + LG +
Sbjct: 198 RAVEALKEAGPVVRLVVRRRQP--------------PPETIMEVNLLKG--PKGLGFSIA 241
Query: 399 RKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS 452
+ PG ++I +++GG A + G+L+ DR+LA+N +L+ E A ++ +
Sbjct: 242 GGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT 301
Query: 453 ERRVHLVVSRQVRQRSPDIFQEAGWNS------------NGSWS-----------PGPGE 489
V+L V++ D++ + S N S P P +
Sbjct: 302 SDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQ 361
Query: 490 RSNT---PKPLH----PTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 542
T P P H T + + + K LG + GG E I+V +
Sbjct: 362 VPPTRYSPIPRHMLAEEDFTREPRKIILHKG-STGLGFNIVGG----EDGEGIFVSFILA 416
Query: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599
GG G ++ GD +L+V+GV L + +A A LKR S+ + V +Y P+E
Sbjct: 417 GGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTI----VAQYRPEE 469
Score = 69.7 bits (169), Expect = 9e-12
Identities = 63/227 (27%), Positives = 97/227 (42%), Gaps = 45/227 (19%)
Query: 504 HEKVVNIQKDPGESLGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNV 561
+E++V + + G LG ++AGG H D I++ + PGG + DGR+ D +L V
Sbjct: 129 YEEIVLERGNSG--LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 562 DGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSP 621
+ V+++EV S AV LK + L V+ +P PP
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPVV---RLVVRRRQP-----------------PPE---- 222
Query: 622 SWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYN 679
++ L + G LGF I GG + G+ +I I+EG A
Sbjct: 223 -------------TIMEVNLLKGPKG-LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQK 268
Query: 680 DGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGT 726
DGR++ GD LLAVN + + H LK + L + PG+
Sbjct: 269 DGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAK-PGS 314
Score = 60.1 bits (144), Expect = 7e-09
Identities = 66/281 (23%), Positives = 106/281 (37%), Gaps = 60/281 (21%)
Query: 273 TSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDIILKVN 328
T +++N + + L + GG + I I I G +DGRL GD +L VN
Sbjct: 223 TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282
Query: 329 GMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD----------------- 371
++ +V H AV L+ +++L V + + PD
Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNS 342
Query: 372 -----------------------AYRP------RDDSF-----HVILNKSSPEEQLGIKL 397
Y P ++ F +IL+K S LG +
Sbjct: 343 SLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTG--LGFNI 400
Query: 398 VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVH 457
V D G+F+ +L GG A G+L DR+L++NG +LR + E AA ++ + + V
Sbjct: 401 VGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVT 460
Query: 458 LVVSRQVRQRS---PDIFQEAGWNSNGSWSPGPGERSNTPK 495
+V + + S I N S S G G + K
Sbjct: 461 IVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK 501
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/90 (32%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 633 LYNCKDIVLRRNTAGSLGFCIVGGYEEYN--GNKPFFIKSIVEGTPAYNDGRIRCGDILL 690
++ ++IVL R +G LGF I GG + + + FI I+ G A DGR+ D +L
Sbjct: 126 MFKYEEIVLERGNSG-LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVL 184
Query: 691 AVNGRSTSGMIHACLARLLKELKGRITLTI 720
VN S ++H+ LKE + L +
Sbjct: 185 RVNEVDVSEVVHSRAVEALKEAGPVVRLVV 214
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 103 bits (256), Expect = 7e-22
Identities = 95/335 (28%), Positives = 142/335 (42%), Gaps = 60/335 (17%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+ +FI ++ GG A + G+L ND +L +N D+R + A ++ + V L V
Sbjct: 249 DDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK 308
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 520
R+ KP+ EK++ I+ G + LG
Sbjct: 309 RR-------------------------------KPVS------EKIMEIKLIKGPKGLGF 331
Query: 521 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
++AGG H D IYV + GG +DG+++ GD LL V+ V L EV+ EAV L
Sbjct: 332 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTAL 391
Query: 579 KRTSSSIVLKALEVKE------YEPQEDCSSPAALDSNH---------NMAPPSDWSPSW 623
K TS + LK + Y P + +S + NH A P+ +SP
Sbjct: 392 KNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVS 451
Query: 624 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683
L + +VL R + G LGF IVGG + + FI I+ G PA G +
Sbjct: 452 KAVLGDDEITREPRKVVLHRGSTG-LGFNIVGGED----GEGIFISFILAGGPADLSGEL 506
Query: 684 RCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
R GD +++VN H A LK +T+
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
Score = 89.7 bits (221), Expect = 8e-18
Identities = 87/357 (24%), Positives = 150/357 (42%), Gaps = 52/357 (14%)
Query: 269 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 324
D E I + R + L + GG++ P + I I I G A+DGRL D I
Sbjct: 219 DYEYEEITLER--GNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCI 276
Query: 325 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 384
L+VN +D+ +V H+ AV L++ ++ L V R +P + I
Sbjct: 277 LRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR---------------KPVSEKIMEIK 321
Query: 385 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 438
P + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 322 LIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 439 YGSPESAAHLIQASERRVHLVVSRQVRQ------RSPDIFQEAGWNSNGSWSPGP--GER 490
+ E A ++ + V+L V++ PDI + + SP G+
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT 440
Query: 491 SNTPKPLHPTITCHEKVVNIQKDP--------GESLGMTVAGGASHREWDLPIYVISVEP 542
+P P I ++P LG + GG E I++ +
Sbjct: 441 PASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG----EDGEGIFISFILA 496
Query: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599
GG G ++ GD +++V+ V+L S +A A LK ++ + V +Y P+E
Sbjct: 497 GGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI----VAQYRPEE 549
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/207 (26%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + GG ++DGR++ D +L V+ V++ +V+ S+AV
Sbjct: 234 LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAV 293
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L VK +P +
Sbjct: 294 EALKEAGSIV---RLYVKRRKPVSE----------------------------------K 316
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I+EG A+ DG+++ GD LLAVN
Sbjct: 317 IMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 694 GRSTSGMIHACLARLLKELKGRITLTI 720
+ H LK + L +
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 59.7 bits (143), Expect = 9e-09
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 40/206 (19%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
I + I G +DG+L GD +L VN + + V H AV L+ ++L V +
Sbjct: 348 IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407
Query: 361 FRSRNNGQAPDA---------------------------YRP------RDDSF-----HV 382
+ PD Y P DD V
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKV 467
Query: 383 ILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSP 442
+L++ S LG +V D G+FI +L GG A G+L + DR++++N DLR S
Sbjct: 468 VLHRGSTG--LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 443 ESAAHLIQASERRVHLVVSRQVRQRS 468
E AA ++ + + V +V + + S
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPEEYS 551
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEE--YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 691
Y ++I L R +G LGF I GG + + FI I+ G A DGR+R D +L
Sbjct: 220 YEYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 692 VNGRSTSGMIHACLARLLKELKGRITLTI 720
VN + H+ LKE + L +
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYV 307
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 103 bits (256), Expect = 7e-22
Identities = 95/335 (28%), Positives = 142/335 (42%), Gaps = 60/335 (17%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+ +FI ++ GG A + G+L ND +L +N D+R + A ++ + V L V
Sbjct: 249 DDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVK 308
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 520
R+ KP+ EK++ I+ G + LG
Sbjct: 309 RR-------------------------------KPVS------EKIMEIKLIKGPKGLGF 331
Query: 521 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
++AGG H D IYV + GG +DG+++ GD LL V+ V L EV+ EAV L
Sbjct: 332 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTAL 391
Query: 579 KRTSSSIVLKALEVKE------YEPQEDCSSPAALDSNH---------NMAPPSDWSPSW 623
K TS + LK + Y P + +S + NH A P+ +SP
Sbjct: 392 KNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVS 451
Query: 624 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683
L + +VL R + G LGF IVGG + + FI I+ G PA G +
Sbjct: 452 KAVLGDDEITREPRKVVLHRGSTG-LGFNIVGGED----GEGIFISFILAGGPADLSGEL 506
Query: 684 RCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
R GD +++VN H A LK +T+
Sbjct: 507 RKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI 541
Score = 89.7 bits (221), Expect = 8e-18
Identities = 87/357 (24%), Positives = 150/357 (42%), Gaps = 52/357 (14%)
Query: 269 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 324
D E I + R + L + GG++ P + I I I G A+DGRL D I
Sbjct: 219 DYEYEEITLER--GNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCI 276
Query: 325 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 384
L+VN +D+ +V H+ AV L++ ++ L V R +P + I
Sbjct: 277 LRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRR---------------KPVSEKIMEIK 321
Query: 385 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 438
P + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 322 LIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 439 YGSPESAAHLIQASERRVHLVVSRQVRQ------RSPDIFQEAGWNSNGSWSPGP--GER 490
+ E A ++ + V+L V++ PDI + + SP G+
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQT 440
Query: 491 SNTPKPLHPTITCHEKVVNIQKDP--------GESLGMTVAGGASHREWDLPIYVISVEP 542
+P P I ++P LG + GG E I++ +
Sbjct: 441 PASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG----EDGEGIFISFILA 496
Query: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599
GG G ++ GD +++V+ V+L S +A A LK ++ + V +Y P+E
Sbjct: 497 GGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI----VAQYRPEE 549
Score = 68.6 bits (166), Expect = 2e-11
Identities = 55/207 (26%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + GG ++DGR++ D +L V+ V++ +V+ S+AV
Sbjct: 234 LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAV 293
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L VK +P +
Sbjct: 294 EALKEAGSIV---RLYVKRRKPVSE----------------------------------K 316
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I+EG A+ DG+++ GD LLAVN
Sbjct: 317 IMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 694 GRSTSGMIHACLARLLKELKGRITLTI 720
+ H LK + L +
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKV 402
Score = 59.7 bits (143), Expect = 9e-09
Identities = 53/206 (25%), Positives = 83/206 (40%), Gaps = 40/206 (19%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
I + I G +DG+L GD +L VN + + V H AV L+ ++L V +
Sbjct: 348 IYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407
Query: 361 FRSRNNGQAPDA---------------------------YRP------RDDSF-----HV 382
+ PD Y P DD V
Sbjct: 408 MYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKV 467
Query: 383 ILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSP 442
+L++ S LG +V D G+FI +L GG A G+L + DR++++N DLR S
Sbjct: 468 VLHRGSTG--LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525
Query: 443 ESAAHLIQASERRVHLVVSRQVRQRS 468
E AA ++ + + V +V + + S
Sbjct: 526 EQAAAALKNAGQAVTIVAQYRPEEYS 551
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/89 (32%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEE--YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 691
Y ++I L R +G LGF I GG + + FI I+ G A DGR+R D +L
Sbjct: 220 YEYEEITLERGNSG-LGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILR 278
Query: 692 VNGRSTSGMIHACLARLLKELKGRITLTI 720
VN + H+ LKE + L +
Sbjct: 279 VNEVDVRDVTHSKAVEALKEAGSIVRLYV 307
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 101 bits (251), Expect = 3e-21
Identities = 118/491 (24%), Positives = 195/491 (39%), Gaps = 96/491 (19%)
Query: 286 LSIRLVGGS-ETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340
L I + GG TP I I + +G AR G + GD +L+VNG+ + H+ A
Sbjct: 738 LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEA 796
Query: 341 VRLLRQPCQVLWLTVMREQKFRSRNNG-----QAPDAYRPRDDSFH----VILNKSSP-- 389
V LR + + V RE+ N + D Y PR+ +L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGP 856
Query: 390 ------------EEQLGIKLVR-------KVDEPGVFIFNVLDGGVAYRHGQLEENDRVL 430
E LG + + + G+F+ + +GG A+R G L+ DRVL
Sbjct: 857 LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916
Query: 431 AINGHDLRYGSPESAAHLIQASERRVHLVVSRQ---------VRQRSPDIFQEAGWNSNG 481
+ING D+ + A L+ A+ + L++ R+ + SP A +
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITT 976
Query: 482 SWSPGPGERSNTPKPLHPTITCHEKVVNIQ-KDPGESLGMTVAGGASHRE-----WDLPI 535
+ PG S P L + V I+ G LG+++ GG+ H + +
Sbjct: 977 ATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGV 1036
Query: 536 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 595
++ V P G+ +R G ++ GD +L V+G ++ + + EAV+ L R + L
Sbjct: 1037 FISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV------ 1089
Query: 596 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVG 655
+ APP +++ +++ LG I G
Sbjct: 1090 --------------RRDPAPP------------------GLRELCIQKAPGERLGISIRG 1117
Query: 656 GYEEYNGN------KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLL 709
G + GN + FI + A DGR+R G LL VN +S G+ H +LL
Sbjct: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Query: 710 KELKGRITLTI 720
+ + +T+ +
Sbjct: 1178 RSVGDTLTVLV 1188
Score = 60.5 bits (145), Expect = 5e-09
Identities = 62/235 (26%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 505 EKVVNIQKDPGESLGMTVAGGASHREW---DLPIYVISVEPGGVISRDGRIKTGDILLNV 561
E + I + G LG+++AGG + D I++ V G +R G ++ GD LL V
Sbjct: 726 ELTLTILRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 562 DGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSP 621
+GV L EAV L+ +++ ++ + EP+ + + P D+SP
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITP-------LRPEDDYSP 836
Query: 622 SW---------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPF------ 666
++ E P L L R+ G LGF I GG G+ P+
Sbjct: 837 RERRGGGLRLPLLPPESPGPLRQRHVACLARSERG-LGFSIAGG----KGSTPYRAGDAG 891
Query: 667 -FIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
F+ I EG A+ G ++ GD +L++NG + H LL I L +
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL 946
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/198 (27%), Positives = 77/198 (38%), Gaps = 34/198 (17%)
Query: 257 PEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSE-------TPLVHIIIQHIYRD 309
P + P L +G +I L + +VGGS+ + I +
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 310 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQA 369
G+ AR G L GD IL VNG D+ + H AV L +PC L L V R+
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD----------- 1092
Query: 370 PDAYRPRDDSFHVILNKSSPEEQLGIKL----------VRKVDEPGVFIFNVLDGGVAYR 419
P + + +P E+LGI + R + G+FI V G A R
Sbjct: 1093 -----PAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGR 1147
Query: 420 HGQLEENDRVLAINGHDL 437
G+L R+L +N L
Sbjct: 1148 DGRLRVGLRLLEVNQQSL 1165
Score = 35.0 bits (79), Expect = 0.25
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 8/82 (9%)
Query: 282 PSESLSIRLVGGSETPLVH--------IIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 333
P E L I + GG+ + I I + G RDGRL G +L+VN +
Sbjct: 1107 PGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLL 1166
Query: 334 NVPHNYAVRLLRQPCQVLWLTV 355
+ H AV+LLR L + V
Sbjct: 1167 GLTHGEAVQLLRSVGDTLTVLV 1188
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 101 bits (251), Expect = 3e-21
Identities = 118/491 (24%), Positives = 195/491 (39%), Gaps = 96/491 (19%)
Query: 286 LSIRLVGGS-ETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340
L I + GG TP I I + +G AR G + GD +L+VNG+ + H+ A
Sbjct: 738 LGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEA 796
Query: 341 VRLLRQPCQVLWLTVMREQKFRSRNNG-----QAPDAYRPRDDSFH----VILNKSSP-- 389
V LR + + V RE+ N + D Y PR+ +L SP
Sbjct: 797 VEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGP 856
Query: 390 ------------EEQLGIKLVR-------KVDEPGVFIFNVLDGGVAYRHGQLEENDRVL 430
E LG + + + G+F+ + +GG A+R G L+ DRVL
Sbjct: 857 LRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVL 916
Query: 431 AINGHDLRYGSPESAAHLIQASERRVHLVVSRQ---------VRQRSPDIFQEAGWNSNG 481
+ING D+ + A L+ A+ + L++ R+ + SP A +
Sbjct: 917 SINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITT 976
Query: 482 SWSPGPGERSNTPKPLHPTITCHEKVVNIQ-KDPGESLGMTVAGGASHRE-----WDLPI 535
+ PG S P L + V I+ G LG+++ GG+ H + +
Sbjct: 977 ATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGV 1036
Query: 536 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 595
++ V P G+ +R G ++ GD +L V+G ++ + + EAV+ L R + L
Sbjct: 1037 FISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLV------ 1089
Query: 596 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVG 655
+ APP +++ +++ LG I G
Sbjct: 1090 --------------RRDPAPP------------------GLRELCIQKAPGERLGISIRG 1117
Query: 656 GYEEYNGN------KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLL 709
G + GN + FI + A DGR+R G LL VN +S G+ H +LL
Sbjct: 1118 GARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLL 1177
Query: 710 KELKGRITLTI 720
+ + +T+ +
Sbjct: 1178 RSVGDTLTVLV 1188
Score = 60.5 bits (145), Expect = 5e-09
Identities = 62/235 (26%), Positives = 99/235 (42%), Gaps = 33/235 (14%)
Query: 505 EKVVNIQKDPGESLGMTVAGGASHREW---DLPIYVISVEPGGVISRDGRIKTGDILLNV 561
E + I + G LG+++AGG + D I++ V G +R G ++ GD LL V
Sbjct: 726 ELTLTILRQTG-GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 562 DGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSP 621
+GV L EAV L+ +++ ++ + EP+ + + P D+SP
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITP-------LRPEDDYSP 836
Query: 622 SW---------VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPF------ 666
++ E P L L R+ G LGF I GG G+ P+
Sbjct: 837 RERRGGGLRLPLLPPESPGPLRQRHVACLARSERG-LGFSIAGG----KGSTPYRAGDAG 891
Query: 667 -FIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
F+ I EG A+ G ++ GD +L++NG + H LL I L +
Sbjct: 892 IFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL 946
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/198 (27%), Positives = 77/198 (38%), Gaps = 34/198 (17%)
Query: 257 PEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSE-------TPLVHIIIQHIYRD 309
P + P L +G +I L + +VGGS+ + I +
Sbjct: 985 PSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPR 1044
Query: 310 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQA 369
G+ AR G L GD IL VNG D+ + H AV L +PC L L V R+
Sbjct: 1045 GLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD----------- 1092
Query: 370 PDAYRPRDDSFHVILNKSSPEEQLGIKL----------VRKVDEPGVFIFNVLDGGVAYR 419
P + + +P E+LGI + R + G+FI V G A R
Sbjct: 1093 -----PAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGR 1147
Query: 420 HGQLEENDRVLAINGHDL 437
G+L R+L +N L
Sbjct: 1148 DGRLRVGLRLLEVNQQSL 1165
Score = 35.0 bits (79), Expect = 0.25
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 8/82 (9%)
Query: 282 PSESLSIRLVGGSETPLVH--------IIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 333
P E L I + GG+ + I I + G RDGRL G +L+VN +
Sbjct: 1107 PGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLL 1166
Query: 334 NVPHNYAVRLLRQPCQVLWLTV 355
+ H AV+LLR L + V
Sbjct: 1167 GLTHGEAVQLLRSVGDTLTVLV 1188
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 97.8 bits (242), Expect = 3e-20
Identities = 100/344 (29%), Positives = 144/344 (41%), Gaps = 72/344 (20%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+P +FI ++ GG A + G+L ND +L +N D+R + +A ++ + V L V
Sbjct: 133 DDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM 192
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 520
R R P EKV+ I+ G + LG
Sbjct: 193 R----RKPPA---------------------------------EKVMEIKLIKGPKGLGF 215
Query: 521 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
++AGG H D IYV + GG +DGR++ GD +L V+ V L +V +AVA L
Sbjct: 216 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL 275
Query: 579 KRTSSSIVLKALEVK------EYEPQE-------------DCSSPAALDSNHNMAP--PS 617
K T + LK + Y P + SS D M P P
Sbjct: 276 KNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPR 335
Query: 618 DWSPSWVMWL---ELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEG 674
+SP L ++PR + IV+ R + G LGF IVGG + + FI I+ G
Sbjct: 336 RYSPVAKDLLGEEDIPR---EPRRIVIHRGSTG-LGFNIVGGED----GEGIFISFILAG 387
Query: 675 TPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
PA G +R GD +L+VNG H A LK +T+
Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
Score = 89.0 bits (219), Expect = 1e-17
Identities = 87/363 (23%), Positives = 153/363 (42%), Gaps = 56/363 (15%)
Query: 269 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 324
+GE+ +I + L + GG++ P + I I I G A+DGRL D I
Sbjct: 101 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 160
Query: 325 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 384
L VN +D+ V H+ AV L++ ++ L VMR + P + + L
Sbjct: 161 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP--------------PAEKVMEIKL 206
Query: 385 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 438
K + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 207 IKG--PKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 264
Query: 439 YGSPESAAHLIQASERRVHLVVSRQVR------QRSPDIFQEAGWNSNGSWSPGPGERSN 492
E A ++ + V+L V++ PDI + + S ++
Sbjct: 265 DVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD 324
Query: 493 TPKPLHPTITCHEKVV--------NIQKDP--------GESLGMTVAGGASHREWDLPIY 536
P + PT V +I ++P LG + GG E I+
Sbjct: 325 YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG----EDGEGIF 380
Query: 537 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 596
+ + GG G ++ GD +L+V+GV+L S +A LK ++ + + +Y+
Sbjct: 381 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI----IAQYK 436
Query: 597 PQE 599
P+E
Sbjct: 437 PEE 439
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 42/215 (19%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + PGG ++DGR++ D +L V+ V++ EV+ S AV
Sbjct: 118 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 177
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L + K PP++
Sbjct: 178 EALKEAGSIVRLYVMRRK---------------------PPAE----------------K 200
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I+EG A+ DGR++ GD +LAVN
Sbjct: 201 VMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 694 GRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 728
++H LK + L + +L
Sbjct: 260 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYL 294
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/216 (25%), Positives = 85/216 (39%), Gaps = 54/216 (25%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
I + I G +DGRL GD IL VN + + +V H AV L+ V++L V +
Sbjct: 232 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP-- 289
Query: 361 FRSRNNGQAPDAYRPRD--------------------DSFHVILNKSSPEEQ-------- 392
+N D+Y P D + + +SP
Sbjct: 290 ----SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLL 345
Query: 393 --------------------LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAI 432
LG +V D G+FI +L GG A G+L + D++L++
Sbjct: 346 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 405
Query: 433 NGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRS 468
NG DLR S E AA ++ + + V ++ + + S
Sbjct: 406 NGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYS 441
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 637 KDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVNG 694
++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L VN
Sbjct: 107 EEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNE 165
Query: 695 RSTSGMIHACLARLLKELKGRITLTIV 721
+ H+ LKE + L ++
Sbjct: 166 VDVREVTHSAAVEALKEAGSIVRLYVM 192
Score = 38.1 bits (87), Expect = 0.029
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 283 SESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVR 342
S L +VGG + I I I G G L GD IL VNG+D+ N H A
Sbjct: 363 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 420
Query: 343 LLRQPCQVLWLTVMREQKFRSRNNGQAPD 371
L+ Q + + + + SR + D
Sbjct: 421 ALKNAGQTVTIIAQYKPEEYSRFEAKIHD 449
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 97.8 bits (242), Expect = 3e-20
Identities = 100/344 (29%), Positives = 144/344 (41%), Gaps = 72/344 (20%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+P +FI ++ GG A + G+L ND +L +N D+R + +A ++ + V L V
Sbjct: 87 DDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM 146
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG-ESLGM 520
R R P EKV+ I+ G + LG
Sbjct: 147 R----RKPPA---------------------------------EKVMEIKLIKGPKGLGF 169
Query: 521 TVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
++AGG H D IYV + GG +DGR++ GD +L V+ V L +V +AVA L
Sbjct: 170 SIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAAL 229
Query: 579 KRTSSSIVLKALEVK------EYEPQE-------------DCSSPAALDSNHNMAP--PS 617
K T + LK + Y P + SS D M P P
Sbjct: 230 KNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPR 289
Query: 618 DWSPSWVMWL---ELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEG 674
+SP L ++PR + IV+ R + G LGF IVGG + + FI I+ G
Sbjct: 290 RYSPVAKDLLGEEDIPR---EPRRIVIHRGSTG-LGFNIVGGED----GEGIFISFILAG 341
Query: 675 TPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718
PA G +R GD +L+VNG H A LK +T+
Sbjct: 342 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385
Score = 89.0 bits (219), Expect = 1e-17
Identities = 87/363 (23%), Positives = 153/363 (42%), Gaps = 56/363 (15%)
Query: 269 DGEITSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDII 324
+GE+ +I + L + GG++ P + I I I G A+DGRL D I
Sbjct: 55 EGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSI 114
Query: 325 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVIL 384
L VN +D+ V H+ AV L++ ++ L VMR + P + + L
Sbjct: 115 LFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKP--------------PAEKVMEIKL 160
Query: 385 NKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLR 438
K + LG + V PG +++ +++GG A++ G+L+ D++LA+N L
Sbjct: 161 IKG--PKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218
Query: 439 YGSPESAAHLIQASERRVHLVVSRQVR------QRSPDIFQEAGWNSNGSWSPGPGERSN 492
E A ++ + V+L V++ PDI + + S ++
Sbjct: 219 DVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD 278
Query: 493 TPKPLHPTITCHEKVV--------NIQKDP--------GESLGMTVAGGASHREWDLPIY 536
P + PT V +I ++P LG + GG E I+
Sbjct: 279 YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG----EDGEGIF 334
Query: 537 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 596
+ + GG G ++ GD +L+V+GV+L S +A LK ++ + + +Y+
Sbjct: 335 ISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI----IAQYK 390
Query: 597 PQE 599
P+E
Sbjct: 391 PEE 393
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 42/215 (19%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + PGG ++DGR++ D +L V+ V++ EV+ S AV
Sbjct: 72 LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAV 131
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L + K PP++
Sbjct: 132 EALKEAGSIVRLYVMRRK---------------------PPAE----------------K 154
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I+EG A+ DGR++ GD +LAVN
Sbjct: 155 VMEIKLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 694 GRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL 728
++H LK + L + +L
Sbjct: 214 SVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYL 248
Score = 62.4 bits (150), Expect = 1e-09
Identities = 54/216 (25%), Positives = 85/216 (39%), Gaps = 54/216 (25%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
I + I G +DGRL GD IL VN + + +V H AV L+ V++L V +
Sbjct: 186 IYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP-- 243
Query: 361 FRSRNNGQAPDAYRPRD--------------------DSFHVILNKSSPEEQ-------- 392
+N D+Y P D + + +SP
Sbjct: 244 ----SNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLL 299
Query: 393 --------------------LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAI 432
LG +V D G+FI +L GG A G+L + D++L++
Sbjct: 300 GEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSV 359
Query: 433 NGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRS 468
NG DLR S E AA ++ + + V ++ + + S
Sbjct: 360 NGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYS 395
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/87 (34%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 637 KDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLAVNG 694
++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L VN
Sbjct: 61 EEITLERGNSG-LGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNE 119
Query: 695 RSTSGMIHACLARLLKELKGRITLTIV 721
+ H+ LKE + L ++
Sbjct: 120 VDVREVTHSAAVEALKEAGSIVRLYVM 146
Score = 38.1 bits (87), Expect = 0.029
Identities = 27/89 (30%), Positives = 37/89 (41%), Gaps = 2/89 (2%)
Query: 283 SESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVR 342
S L +VGG + I I I G G L GD IL VNG+D+ N H A
Sbjct: 317 STGLGFNIVGGEDGE--GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAI 374
Query: 343 LLRQPCQVLWLTVMREQKFRSRNNGQAPD 371
L+ Q + + + + SR + D
Sbjct: 375 ALKNAGQTVTIIAQYKPEEYSRFEAKIHD 403
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 94.7 bits (234), Expect = 3e-19
Identities = 97/363 (26%), Positives = 146/363 (40%), Gaps = 87/363 (23%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+PG+FI ++ GG A G+L ND +L +N D+ S A ++ + V L V
Sbjct: 72 DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 131
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 521
R+ +P+ T+ + + K P + LG +
Sbjct: 132 RR-------------------------------RPILETVV----EIKLFKGP-KGLGFS 155
Query: 522 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579
+AGG H D IYV + GG +DGR++ GD LL V+ L EV+ EAVA+LK
Sbjct: 156 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215
Query: 580 RTSSSIVLKALE------VKEYEPQEDCSSPAALDSNHNMA---------------PPSD 618
TS + LK + Y P + S + NH ++ P
Sbjct: 216 NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGR 275
Query: 619 WSPSWVMWL--------------------ELPRCLY---NCKDIVLRRNTAGSLGFCIVG 655
+SP L L R + + +VL + + G LGF IVG
Sbjct: 276 YSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTG-LGFNIVG 334
Query: 656 GYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGR 715
G + + F+ I+ G PA G ++ GD +L+VNG G H A LK
Sbjct: 335 GED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 390
Query: 716 ITL 718
+T+
Sbjct: 391 VTI 393
Score = 90.9 bits (224), Expect = 4e-18
Identities = 97/396 (24%), Positives = 163/396 (41%), Gaps = 85/396 (21%)
Query: 283 SESLSIRLVGGSETPLVH----IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHN 338
+ L + GG++ P + I I I G A DGRL D IL+VN +D+S V H+
Sbjct: 54 NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHS 113
Query: 339 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLV 398
AV L++ ++ L V R RP ++ I P+ LG +
Sbjct: 114 KAVEALKEAGSIVRLYVRRR---------------RPILETVVEIKLFKGPKG-LGFSIA 157
Query: 399 RKVDE---PG---VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS 452
V PG +++ ++DGG A + G+L+ DR+L +N + L + E A +++ +
Sbjct: 158 GGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT 217
Query: 453 ERRVHLVVSRQ--------------VRQRSPDIFQEAGWNSNG------SWSP-GPGERS 491
V+L V + SP + +NG S P PG S
Sbjct: 218 SEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYS 277
Query: 492 NTPKPL-----------HPTITCH-----EKVVNIQKDP--------GESLGMTVAGGAS 527
PK + H T T ++ V+++ +P LG + GG
Sbjct: 278 PIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-- 335
Query: 528 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 587
E I+V + GG G ++ GD +L+V+G++L S +A A LK ++ +
Sbjct: 336 --EDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Query: 588 KALEVKEYEPQEDCSSPAALDS------NHNMAPPS 617
+ +Y+P++ A + NH+M+ S
Sbjct: 394 ----IAQYQPEDYARFEAKIHDLREQMMNHSMSSGS 425
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + PGG + DGR++ D +L V+ V+++EVS S+AV
Sbjct: 57 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 116
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L V+ P L
Sbjct: 117 EALKEAGSIV---RLYVRRRRP----------------------------------ILET 139
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I++G A DGR++ GD LL VN
Sbjct: 140 VVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198
Query: 694 GRSTSGMIHACLARLLKELKGRITLTI 720
S + H +LK + L +
Sbjct: 199 NYSLEEVTHEEAVAILKNTSEVVYLKV 225
Score = 48.1 bits (113), Expect = 3e-05
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLA 691
Y ++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L
Sbjct: 43 YEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101
Query: 692 VNGRSTSGMIHACLARLLKELKGRITLTI 720
VN S + H+ LKE + L +
Sbjct: 102 VNEVDVSEVSHSKAVEALKEAGSIVRLYV 130
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/379 (26%), Positives = 159/379 (41%), Gaps = 68/379 (17%)
Query: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 462
+PG+FI +++ GG A + ++ ++LA+N L + A +IQ S + L++S+
Sbjct: 778 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 837
Query: 463 Q--VRQRSPDIFQEAGWNSNGS-------------------------------------- 482
V +PD + + NS S
Sbjct: 838 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 897
Query: 483 ------WSPGPGERSNTPKPLHPTITCHE-KVVNIQKDPGESLGMTVAGGASHREWDLPI 535
+ P G S+ P P P I+ E V + K+ G +LG +V GG + I
Sbjct: 898 LRHQLSFLPLKGAGSSCP-PSPPEISAGEIYFVELVKEDG-TLGFSVTGGINTSVPYGGI 955
Query: 536 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 595
YV S+ PGG +++G+I GD LL VDGV L ++ +AV L + L ++
Sbjct: 956 YVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ---VARLVLERR 1012
Query: 596 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDI-------VLRRNTAGS 648
P+ P+A DS D + + LP +C + V + A
Sbjct: 1013 VPRSTQQCPSANDSM------GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG 1066
Query: 649 LGFCIVGGYEE---YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACL 705
LGF V +E + + IK + G PA +G I GDI+LAVNGRST G+I +
Sbjct: 1067 LGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEV 1126
Query: 706 ARLLKELKGRITLTIVSWP 724
LL+ +TL + P
Sbjct: 1127 LHLLRGAPQEVTLLLCRPP 1145
Score = 55.8 bits (133), Expect = 1e-07
Identities = 69/291 (23%), Positives = 112/291 (38%), Gaps = 58/291 (19%)
Query: 237 GSAVANHADQGRENSENTTA--PEVFPRLYHL-------------------IPDGEITSI 275
GS +++ DQ R E A + PRL H I GEI +
Sbjct: 870 GSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFV 929
Query: 276 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 335
++ + D + S+ + P I ++ I G A++G++L GD +L+V+G+ + +
Sbjct: 930 ELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 989
Query: 336 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS---------------- 379
H AV+ L P QV L + R R+ Q P A D
Sbjct: 990 THKQAVQCLTGPGQVARLVLERRVP---RSTQQCPSANDSMGDERTAVSLVTALPGRPSS 1046
Query: 380 ---------FHVILNKSSPEEQLGIKLVRKVDEPG-------VFIFNVLDGGVAYRHGQL 423
F V L K++ LG V+ E V I + G A +G +
Sbjct: 1047 CVSVTDGPKFEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAI 1104
Query: 424 EENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
D +LA+NG + HL++ + + V L++ R P++ QE
Sbjct: 1105 AAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQE 1155
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/241 (23%), Positives = 93/241 (38%), Gaps = 49/241 (20%)
Query: 508 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 567
V +++DP G + G + D I++ S+ PGG + IK G +L ++ + L
Sbjct: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
Query: 568 EVSRSEAVALLKRTSSSIVL---KALEVKEYEPQEDCSSPA------------------- 605
+ + AV +++ + +I L ++ V P E+ +S A
Sbjct: 814 GFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLL 873
Query: 606 --ALDSNHN-----MAPPSDWSP---SWVMWLELPRCLYNCK--------------DIVL 641
D + N MA P + +L L +C ++V
Sbjct: 874 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 933
Query: 642 RRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 701
T G F + GG ++KSIV G PA +G+I GD LL V+G G+
Sbjct: 934 EDGTLG---FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 990
Query: 702 H 702
H
Sbjct: 991 H 991
Score = 35.8 bits (81), Expect = 0.14
Identities = 24/82 (29%), Positives = 35/82 (42%)
Query: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 698
+ L+R+ GF I G + FI SI+ G PA I+ G +LA+N S
Sbjct: 754 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 813
Query: 699 GMIHACLARLLKELKGRITLTI 720
G R+++ I L I
Sbjct: 814 GFTFNMAVRMIQNSPDNIELII 835
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 92.0 bits (227), Expect = 2e-18
Identities = 102/379 (26%), Positives = 159/379 (41%), Gaps = 68/379 (17%)
Query: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 462
+PG+FI +++ GG A + ++ ++LA+N L + A +IQ S + L++S+
Sbjct: 800 DPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQ 859
Query: 463 Q--VRQRSPDIFQEAGWNSNGS-------------------------------------- 482
V +PD + + NS S
Sbjct: 860 SKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPR 919
Query: 483 ------WSPGPGERSNTPKPLHPTITCHE-KVVNIQKDPGESLGMTVAGGASHREWDLPI 535
+ P G S+ P P P I+ E V + K+ G +LG +V GG + I
Sbjct: 920 LRHQLSFLPLKGAGSSCP-PSPPEISAGEIYFVELVKEDG-TLGFSVTGGINTSVPYGGI 977
Query: 536 YVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEY 595
YV S+ PGG +++G+I GD LL VDGV L ++ +AV L + L ++
Sbjct: 978 YVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQ---VARLVLERR 1034
Query: 596 EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDI-------VLRRNTAGS 648
P+ P+A DS D + + LP +C + V + A
Sbjct: 1035 VPRSTQQCPSANDSM------GDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANG 1088
Query: 649 LGFCIVGGYEE---YNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACL 705
LGF V +E + + IK + G PA +G I GDI+LAVNGRST G+I +
Sbjct: 1089 LGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEV 1148
Query: 706 ARLLKELKGRITLTIVSWP 724
LL+ +TL + P
Sbjct: 1149 LHLLRGAPQEVTLLLCRPP 1167
Score = 55.8 bits (133), Expect = 1e-07
Identities = 69/291 (23%), Positives = 112/291 (38%), Gaps = 58/291 (19%)
Query: 237 GSAVANHADQGRENSENTTA--PEVFPRLYHL-------------------IPDGEITSI 275
GS +++ DQ R E A + PRL H I GEI +
Sbjct: 892 GSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFV 951
Query: 276 KINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNV 335
++ + D + S+ + P I ++ I G A++G++L GD +L+V+G+ + +
Sbjct: 952 ELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGL 1011
Query: 336 PHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDS---------------- 379
H AV+ L P QV L + R R+ Q P A D
Sbjct: 1012 THKQAVQCLTGPGQVARLVLERRVP---RSTQQCPSANDSMGDERTAVSLVTALPGRPSS 1068
Query: 380 ---------FHVILNKSSPEEQLGIKLVRKVDEPG-------VFIFNVLDGGVAYRHGQL 423
F V L K++ LG V+ E V I + G A +G +
Sbjct: 1069 CVSVTDGPKFEVKLKKNA--NGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAI 1126
Query: 424 EENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
D +LA+NG + HL++ + + V L++ R P++ QE
Sbjct: 1127 AAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQE 1177
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/241 (23%), Positives = 93/241 (38%), Gaps = 49/241 (20%)
Query: 508 VNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 567
V +++DP G + G + D I++ S+ PGG + IK G +L ++ + L
Sbjct: 776 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835
Query: 568 EVSRSEAVALLKRTSSSIVL---KALEVKEYEPQEDCSSPA------------------- 605
+ + AV +++ + +I L ++ V P E+ +S A
Sbjct: 836 GFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLL 895
Query: 606 --ALDSNHN-----MAPPSDWSP---SWVMWLELPRCLYNCK--------------DIVL 641
D + N MA P + +L L +C ++V
Sbjct: 896 SHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVK 955
Query: 642 RRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMI 701
T G F + GG ++KSIV G PA +G+I GD LL V+G G+
Sbjct: 956 EDGTLG---FSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLT 1012
Query: 702 H 702
H
Sbjct: 1013 H 1013
Score = 35.8 bits (81), Expect = 0.14
Identities = 24/82 (29%), Positives = 35/82 (42%)
Query: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 698
+ L+R+ GF I G + FI SI+ G PA I+ G +LA+N S
Sbjct: 776 VTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLE 835
Query: 699 GMIHACLARLLKELKGRITLTI 720
G R+++ I L I
Sbjct: 836 GFTFNMAVRMIQNSPDNIELII 857
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 83.6 bits (205), Expect = 6e-16
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 41/219 (18%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+PG+FI ++ GG A G+L ND +L +N D+ S A ++ + V L V
Sbjct: 228 DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 287
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 521
R+ +P+ T+ + + K P + LG +
Sbjct: 288 RR-------------------------------RPILETVV----EIKLFKGP-KGLGFS 311
Query: 522 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579
+AGG H D IYV + GG +DGR++ GD LL V+ L EV+ EAVA+LK
Sbjct: 312 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 371
Query: 580 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 618
TS + LK + + P D H+ +PP +
Sbjct: 372 NTSEVVYLKVGKPTTIYMTDPYGPP---DITHSYSPPME 407
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + PGG + DGR++ D +L V+ V+++EVS S+AV
Sbjct: 213 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 272
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L V+ P L
Sbjct: 273 EALKEAGSIV---RLYVRRRRP----------------------------------ILET 295
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I++G A DGR++ GD LL VN
Sbjct: 296 VVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354
Query: 694 GRSTSGMIHACLARLLKELKGRITLTI 720
S + H +LK + L +
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKV 381
Score = 68.9 bits (167), Expect = 2e-11
Identities = 59/220 (26%), Positives = 98/220 (44%), Gaps = 28/220 (12%)
Query: 253 NTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH----IIIQHIYR 308
NT + P + + E I + R + L + GG++ P + I I I
Sbjct: 182 NTDTLDTIPYVNGTEIEYEFEEITLER--GNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 239
Query: 309 DGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQ 368
G A DGRL D IL+VN +D+S V H+ AV L++ ++ L V R
Sbjct: 240 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR---------- 289
Query: 369 APDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQ 422
RP ++ I P+ LG + V PG +++ ++DGG A + G+
Sbjct: 290 -----RPILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 343
Query: 423 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 462
L+ DR+L +N + L + E A +++ + V+L V +
Sbjct: 344 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383
Score = 54.3 bits (129), Expect = 4e-07
Identities = 75/360 (20%), Positives = 135/360 (37%), Gaps = 36/360 (10%)
Query: 273 TSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDIILKVN 328
T ++I + L + GG + I + I G +DGRL GD +L VN
Sbjct: 295 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354
Query: 329 GMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD---AYRPRDDSFHVILN 385
+ V H AV +L+ +V++L V + + PD +Y P ++ + N
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 414
Query: 386 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 445
+ E + + + + ++D + L R+ SP
Sbjct: 415 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVEC 474
Query: 446 --AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITC 503
+ L+ A HL + ++ S+ S + S T +
Sbjct: 475 DKSFLLSAPYSHYHL-----------GLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 523
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
KVV + G LG + GG I+V + GG G ++ GD +L+V+G
Sbjct: 524 PRKVVLHKGSTG--LGFNIVGGEDGEG----IFVSFILAGGPADLSGELQRGDQILSVNG 577
Query: 564 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDS------NHNMAPPS 617
++L S +A A LK ++ + + +Y+P++ A + NH+M+ S
Sbjct: 578 IDLRGASHEQAAAALKGAGQTVTI----IAQYQPEDYARFEAKIHDLREQMMNHSMSSGS 633
Score = 48.1 bits (113), Expect = 3e-05
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLA 691
Y ++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L
Sbjct: 199 YEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 257
Query: 692 VNGRSTSGMIHACLARLLKELKGRITLTI 720
VN S + H+ LKE + L +
Sbjct: 258 VNEVDVSEVSHSKAVEALKEAGSIVRLYV 286
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 637 KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS 696
+ +VL + + G LGF IVGG + + F+ I+ G PA G ++ GD +L+VNG
Sbjct: 525 RKVVLHKGSTG-LGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGID 579
Query: 697 TSGMIHACLARLLKELKGRITL 718
G H A LK +T+
Sbjct: 580 LRGASHEQAAAALKGAGQTVTI 601
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 83.6 bits (205), Expect = 6e-16
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 41/219 (18%)
Query: 402 DEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS 461
D+PG+FI ++ GG A G+L ND +L +N D+ S A ++ + V L V
Sbjct: 123 DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVR 182
Query: 462 RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 521
R+ +P+ T+ + + K P + LG +
Sbjct: 183 RR-------------------------------RPILETVV----EIKLFKGP-KGLGFS 206
Query: 522 VAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579
+AGG H D IYV + GG +DGR++ GD LL V+ L EV+ EAVA+LK
Sbjct: 207 IAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 266
Query: 580 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 618
TS + LK + + P D H+ +PP +
Sbjct: 267 NTSEVVYLKVGKPTTIYMTDPYGPP---DITHSYSPPME 302
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/207 (28%), Positives = 88/207 (42%), Gaps = 42/207 (20%)
Query: 518 LGMTVAGGAS--HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
LG ++AGG H D I++ + PGG + DGR++ D +L V+ V+++EVS S+AV
Sbjct: 108 LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAV 167
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN 635
LK S + L V+ P L
Sbjct: 168 EALKEAGSIV---RLYVRRRRP----------------------------------ILET 190
Query: 636 CKDIVLRRNTAGSLGFCIVGGY--EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+I L + G LGF I GG + G+ ++ I++G A DGR++ GD LL VN
Sbjct: 191 VVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 694 GRSTSGMIHACLARLLKELKGRITLTI 720
S + H +LK + L +
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKV 276
Score = 68.9 bits (167), Expect = 2e-11
Identities = 59/220 (26%), Positives = 98/220 (44%), Gaps = 28/220 (12%)
Query: 253 NTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVH----IIIQHIYR 308
NT + P + + E I + R + L + GG++ P + I I I
Sbjct: 77 NTDTLDTIPYVNGTEIEYEFEEITLER--GNSGLGFSIAGGTDNPHIGDDPGIFITKIIP 134
Query: 309 DGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQ 368
G A DGRL D IL+VN +D+S V H+ AV L++ ++ L V R
Sbjct: 135 GGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR---------- 184
Query: 369 APDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDE---PG---VFIFNVLDGGVAYRHGQ 422
RP ++ I P+ LG + V PG +++ ++DGG A + G+
Sbjct: 185 -----RPILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGR 238
Query: 423 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSR 462
L+ DR+L +N + L + E A +++ + V+L V +
Sbjct: 239 LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278
Score = 54.3 bits (129), Expect = 4e-07
Identities = 75/360 (20%), Positives = 135/360 (37%), Gaps = 36/360 (10%)
Query: 273 TSIKINRVDPSESLSIRLVGGSETPLV----HIIIQHIYRDGVIARDGRLLPGDIILKVN 328
T ++I + L + GG + I + I G +DGRL GD +L VN
Sbjct: 190 TVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 329 GMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPD---AYRPRDDSFHVILN 385
+ V H AV +L+ +V++L V + + PD +Y P ++ + N
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 309
Query: 386 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 445
+ E + + + + ++D + L R+ SP
Sbjct: 310 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVEC 369
Query: 446 --AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITC 503
+ L+ A HL + ++ S+ S + S T +
Sbjct: 370 DKSFLLSAPYSHYHL-----------GLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGE 418
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
KVV + G LG + GG I+V + GG G ++ GD +L+V+G
Sbjct: 419 PRKVVLHKGSTG--LGFNIVGGEDGEG----IFVSFILAGGPADLSGELQRGDQILSVNG 472
Query: 564 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDS------NHNMAPPS 617
++L S +A A LK ++ + + +Y+P++ A + NH+M+ S
Sbjct: 473 IDLRGASHEQAAAALKGAGQTVTI----IAQYQPEDYARFEAKIHDLREQMMNHSMSSGS 528
Score = 48.1 bits (113), Expect = 3e-05
Identities = 32/89 (35%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEE-YNGNKP-FFIKSIVEGTPAYNDGRIRCGDILLA 691
Y ++I L R +G LGF I GG + + G+ P FI I+ G A DGR+R D +L
Sbjct: 94 YEFEEITLERGNSG-LGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 152
Query: 692 VNGRSTSGMIHACLARLLKELKGRITLTI 720
VN S + H+ LKE + L +
Sbjct: 153 VNEVDVSEVSHSKAVEALKEAGSIVRLYV 181
Score = 42.4 bits (98), Expect = 0.002
Identities = 28/82 (34%), Positives = 42/82 (51%), Gaps = 5/82 (6%)
Query: 637 KDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRS 696
+ +VL + + G LGF IVGG + + F+ I+ G PA G ++ GD +L+VNG
Sbjct: 420 RKVVLHKGSTG-LGFNIVGGED----GEGIFVSFILAGGPADLSGELQRGDQILSVNGID 474
Query: 697 TSGMIHACLARLLKELKGRITL 718
G H A LK +T+
Sbjct: 475 LRGASHEQAAAALKGAGQTVTI 496
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 82.4 bits (202), Expect = 1e-15
Identities = 111/529 (20%), Positives = 198/529 (37%), Gaps = 113/529 (21%)
Query: 34 EVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSIL 93
+VD DL C +C + L DPL TPCGH +C C+ ++V++ CP + + +
Sbjct: 11 DVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLP 70
Query: 94 VNKLLNKLLVTCPFREH-CTQVLQRCDLEHHFQ------TSCK--GASHYGLTKDRKRRS 144
+ +L+ KL + C + C +V++ L H + C+ G L +D +
Sbjct: 71 LKRLILKLDIKCAYATRGCGRVVKLQQLPEHLERCDFAPARCRHAGCGQVLLRRDVEAHM 130
Query: 145 QDGCPDGCASLTATAPSPEVSAAATISLMTDE--PGLDNPAYVSSAEDG--QPAISPVDS 200
+D C P + L E G A A +G Q + +
Sbjct: 131 RDACD--------ARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHK 182
Query: 201 G-RSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEV 259
+ RA E+S + + ++ ++ LR K + + D S AP
Sbjct: 183 ALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLD---SLSRCVAAP-- 237
Query: 260 FPRLYHLIPDG---EITSIKINRVDPSESLSIRLVGGSETPLVH-------IIIQHIYRD 309
P G E S+ + S SL ++GG + H I + I
Sbjct: 238 --------PGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDS 289
Query: 310 GVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE----QKFRSRN 365
G A++G L D I++VNG D+S H+ AV + + + + V+R + F +
Sbjct: 290 GPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPS 349
Query: 366 NGQAPDAYRPRDDSFHVIL---NKSSP--------------------------------- 389
Q D D +F I+ SSP
Sbjct: 350 ESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGDIHQE 409
Query: 390 ------------------EEQLGIKLVRKVDEP---GVFIFNVLDGGVAYRHGQLEENDR 428
+++LG+ + + D+ G++I + +A + G++ E DR
Sbjct: 410 MDREELELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDR 469
Query: 429 VLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGW 477
++ ING +++ E+ A L + L+++R P++ + GW
Sbjct: 470 IIQINGIEVQ-NREEAVALLTSEENKNFSLLIAR------PELQLDEGW 511
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/212 (25%), Positives = 95/212 (44%), Gaps = 41/212 (19%)
Query: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ-ASERRVHLVVSRQ 463
G+F+ ++D G A + G L+ +DR++ +NG DL + + A + A E V V+ R
Sbjct: 280 GIFVSKIVDSGPAAKEGGLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRT 339
Query: 464 VRQRSPDIFQEAGWNSNGSWSPGPGER--------SNTPKPLHPTI------TCHE---- 505
R + E+ G+ + E S +P L P + + HE
Sbjct: 340 PRTKMFTPPSESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAHEYYDP 399
Query: 506 -------------------KVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVI 546
+V + + + LG+TV + D+ IY+ ++P +
Sbjct: 400 NDYIGDIHQEMDREELELEEVDLYRMNSQDKLGLTVCYRTDDED-DIGIYISEIDPNSIA 458
Query: 547 SRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
++DGRI+ GD ++ ++G+E+ +R EAVALL
Sbjct: 459 AKDGRIREGDRIIQINGIEVQ--NREEAVALL 488
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/88 (31%), Positives = 47/88 (53%), Gaps = 6/88 (6%)
Query: 639 IVLRRNTAGSLGFCIVGG---YEEYNG--NKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
+VL R++ GSLGF I+GG + ++G ++ F+ IV+ PA +G ++ D ++ VN
Sbjct: 250 LVLHRDS-GSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVN 308
Query: 694 GRSTSGMIHACLARLLKELKGRITLTIV 721
GR S H K K I + ++
Sbjct: 309 GRDLSRATHDQAVEAFKTAKEPIVVQVL 336
Score = 38.9 bits (89), Expect = 0.017
Identities = 50/228 (21%), Positives = 89/228 (39%), Gaps = 47/228 (20%)
Query: 510 IQKDPGESLGMTVAGGASHRE-----WDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 564
+ +D G SLG + GG + I+V + G +++G ++ D ++ V+G
Sbjct: 252 LHRDSG-SLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGR 310
Query: 565 ELTEVSRSEAVALLKRTSSSIVLKAL----EVKEYEPQEDCS------------------ 602
+L+ + +AV K IV++ L K + P +
Sbjct: 311 DLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFEHIMAL 370
Query: 603 ------SPAALD---------SNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVL-RRNTA 646
SP LD S H P+D+ + E+ R +++ L R N+
Sbjct: 371 TKMSSPSPPVLDPYLLPEEHPSAHEYYDPNDYIGD--IHQEMDREELELEEVDLYRMNSQ 428
Query: 647 GSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG 694
LG + ++ + +I I + A DGRIR GD ++ +NG
Sbjct: 429 DKLGLTVCYRTDD-EDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 80.9 bits (198), Expect = 4e-15
Identities = 91/357 (25%), Positives = 141/357 (39%), Gaps = 66/357 (18%)
Query: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERR----VHLVV 460
G+ + + GG A END ++ IN DLR E A H+ + + R H+V
Sbjct: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359
Query: 461 S------RQVRQRSPDIFQEAGWNSNGSW-------SPGPGERSNTPKPLHPT--ITCHE 505
+ Q+ Q + + + ++ + + S G P+ HP I H
Sbjct: 360 AANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHS 419
Query: 506 KV--------------------------------------VNIQKDPG-ESLGMTVAGGA 526
++ +NIQ G E LG ++
Sbjct: 420 RLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRD 479
Query: 527 SHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIV 586
PIYV ++ P G +DGR+K GD L+ V+GV+L S+ E V+LL+ T
Sbjct: 480 VTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGT 539
Query: 587 LKALEVKEYEPQEDCSSPAALDSN-HNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNT 645
+ L + QED P L++ M P + + P + N
Sbjct: 540 VSLLVFR----QEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLND 595
Query: 646 AGS--LGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSG 699
+GS LG + G +E + + F+KSI+ G A DGR+R D L+AVNG S G
Sbjct: 596 SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLG 652
Score = 68.2 bits (165), Expect = 3e-11
Identities = 55/186 (29%), Positives = 92/186 (49%), Gaps = 12/186 (6%)
Query: 406 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS--ERRVHLVVSRQ 463
+++ N+L G A + G+L+ DR++ +NG DL S E L++++ E V L+V RQ
Sbjct: 488 IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ 547
Query: 464 VRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ---KDPGES-LG 519
D F N+ S P E + + T + + + D G + LG
Sbjct: 548 -----EDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLG 602
Query: 520 MTVAGGASHREW-DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
++V G S DL I+V S+ GG S+DGR++ D L+ V+G L + +A+ L
Sbjct: 603 VSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETL 662
Query: 579 KRTSSS 584
+R+ S+
Sbjct: 663 RRSMST 668
Score = 58.2 bits (139), Expect = 3e-08
Identities = 53/208 (25%), Positives = 92/208 (44%), Gaps = 39/208 (18%)
Query: 291 VGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ- 349
+GGS I +++I G +DGRL GD +++VNG+D+ V LLR
Sbjct: 482 IGGSAP----IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537
Query: 350 --VLWLTVMREQKFRSR------NNGQAPDAYRPRDD-------------SFHVILNKSS 388
V L +E F R + Q P + D+ +F V LN S
Sbjct: 538 GTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSG 597
Query: 389 PEEQLGIKLVRKVDEP-----GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPE 443
LG+ + + G+F+ ++++GG A + G+L ND+++A+NG L + +
Sbjct: 598 -SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
Query: 444 SAAHLIQAS-------ERRVHLVVSRQV 464
A ++ S + L+V+R++
Sbjct: 657 DAMETLRRSMSTEGNKRGMIQLIVARRI 684
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/84 (32%), Positives = 44/84 (52%), Gaps = 1/84 (1%)
Query: 638 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697
+I L++ T G LGF I G+ P ++K+I+ A DGR++ GD L+ VNG
Sbjct: 461 NIQLKKGTEG-LGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDL 519
Query: 698 SGMIHACLARLLKELKGRITLTIV 721
G + LL+ K T++++
Sbjct: 520 VGKSQEEVVSLLRSTKMEGTVSLL 543
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 79.7 bits (195), Expect = 9e-15
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)
Query: 465 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 524
+ +SP + + G S+ S SP G SN + ++++K P E LG TV
Sbjct: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
Query: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 581
S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T
Sbjct: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
Query: 582 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 636
++S+V+ E +E + + DC + +L+++ + E+P
Sbjct: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
Query: 637 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 695
L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG
Sbjct: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
Query: 696 STSGMI-HACLARLLK------ELKGRITLTIVSWP 724
S G H + L + ++G I L I+ P
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Score = 62.8 bits (151), Expect = 1e-09
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 358
I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 359 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 407
+ F R PD +F + LN S LG+ L G+F
Sbjct: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
Query: 408 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 460
I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+
Sbjct: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
Query: 461 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 503
R+ + D + ++ + R N LHP TC
Sbjct: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 79.7 bits (195), Expect = 9e-15
Identities = 77/276 (27%), Positives = 129/276 (46%), Gaps = 48/276 (17%)
Query: 465 RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAG 524
+ +SP + + G S+ S SP G SN + ++++K P E LG TV
Sbjct: 349 QNKSPRVPRLGGKPSSPSLSPLMGFGSNK--------NAKKIKIDLKKGP-EGLGFTVVT 399
Query: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRT--- 581
S PI+V ++ P G +DGR+++GD +L V+G ++T ++ E VA+L+ T
Sbjct: 400 RDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459
Query: 582 -SSSIVLKALE----VKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 636
++S+V+ E +E + + DC + +L+++ + E+P
Sbjct: 460 ETASLVIARQEGHFLPRELKGEPDCCA-LSLETSEQLT------------FEIP------ 500
Query: 637 KDIVLRRNTAGSLGFCIVGGYEEYNG-NKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGR 695
L + + LG + G G + FIKSI+ G A+ DGR+R D L+AVNG
Sbjct: 501 ----LNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556
Query: 696 STSGMI-HACLARLLK------ELKGRITLTIVSWP 724
S G H + L + ++G I L I+ P
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRP 592
Score = 62.8 bits (151), Expect = 1e-09
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 24/226 (10%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQ--VLWLTVMRE 358
I +++I G +DGRL GD IL+VNG D++ V +LR Q L + R+
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 359 Q-KFRSRNNGQAPDAYR-----PRDDSFHVILNKSSPEEQLGIKLVRKVDEP-----GVF 407
+ F R PD +F + LN S LG+ L G+F
Sbjct: 470 EGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSG-SAGLGVSLKGNKSRETGTDLGIF 528
Query: 408 IFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQAS-------ERRVHLVV 460
I +++ GG A++ G+L ND+++A+NG L S A ++ S + LV+
Sbjct: 529 IKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVI 588
Query: 461 SRQVRQRSPDIFQEAGWNS---NGSWSPGPGERSNTPKPLHPTITC 503
R+ + D + ++ + R N LHP TC
Sbjct: 589 LRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRNDNSILHPLGTC 634
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 79.0 bits (193), Expect = 1e-14
Identities = 104/495 (21%), Positives = 191/495 (38%), Gaps = 91/495 (18%)
Query: 276 KINRVDPSESLSIRLVGG--SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDIS 333
K+ + S+ L I++ GG S+ I++ + G RDGRL GD +L +NG +
Sbjct: 334 KMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLV 393
Query: 334 NVPHNYAVRLLRQPCQVLWLTVMREQK----------------------FRSRNNGQAPD 371
+ H AV +LR ++ L V ++ S + + +
Sbjct: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQE 453
Query: 372 AYRPRDDSFHVILNKSSP-----------EEQLGIKLVRKVDEPGVFIFNVLDGGVAYRH 420
A D+ + ++ P EE G K + + + L GGV +R
Sbjct: 454 ADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGV-HRL 512
Query: 421 GQLEENDRVLAINGHDL-------RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 473
+EE + ++ NG R G S L+ +S + ++ +
Sbjct: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQV 572
Query: 474 EAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDL 533
E+ W + + P++ ++ + K+ G+ LG ++AGG +
Sbjct: 573 ESPW-----------------RLIRPSVI---SIIGLYKEKGKGLGFSIAGGRDCIRGQM 612
Query: 534 PIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVK 593
I+V ++ P G + DGR+K GD +L+V+G+ + ++ EA+ K+ S + + + K
Sbjct: 613 GIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
Query: 594 EYEPQ-EDCSSPAALD---------SNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRR 643
P CS+P + S A SD S + + P KD ++
Sbjct: 673 LVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTP----GPKDRIVME 728
Query: 644 NTAG-------SLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG-- 694
T +G C + N +I S+ G+ A + + GD +L VN
Sbjct: 729 VTLNKEPRVGLGIGACCLA---LENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVN 785
Query: 695 --RSTSGMIHACLAR 707
+ +HA L++
Sbjct: 786 VRHAALSKVHAILSK 800
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/215 (23%), Positives = 93/215 (43%), Gaps = 11/215 (5%)
Query: 510 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 569
+ + G LG +VAGG + ++ + + G S++G + GD LL+V+G L +
Sbjct: 2625 LNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQ--GAASQEGTMNRGDFLLSVNGASLAGL 2682
Query: 570 SRSEAVALLKRTS---SSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
+ + +L + ++V+ + + P P A P
Sbjct: 2683 AHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRS 2742
Query: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCG 686
+ + L C +++ T+ LG + GG G+ P IK + +G A G I G
Sbjct: 2743 VAVHDAL--CVEVL---KTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAG 2797
Query: 687 DILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 720
D +LA+NG+ G++H ++K + +G + L I
Sbjct: 2798 DEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLI 2832
Score = 57.4 bits (137), Expect = 5e-08
Identities = 77/330 (23%), Positives = 136/330 (41%), Gaps = 36/330 (10%)
Query: 406 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVS---- 461
+ + V +GG A+R G+L D +L INGH L S E A +++++ V LVV+
Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKEN 420
Query: 462 ------RQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPG 515
R + PD+ SW+ + ++ + T + ++ + +P
Sbjct: 421 SAEDLLRLTSKSLPDLTSSV--EDVSSWTDNEDQEADGEED-EGTSSSVQRAMPGTDEPQ 477
Query: 516 ESLGMTVAGG--ASHREWDLPIYVISVEPGGVISRDGRIKTGDILL-NVDG-VELTEVSR 571
+ G + G S ++ I + S GGV + + ++++ N D + + EVSR
Sbjct: 478 DVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSR 537
Query: 572 SEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPR 631
K + ++ + +EY + S +L + +P PS +
Sbjct: 538 DGR----KHSLPQLLDSSSASQEYHIVK--KSTRSLSTTQVESPWRLIRPSVI------- 584
Query: 632 CLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLA 691
I L + LGF I GG + G F+K+I A DGR++ GD +L
Sbjct: 585 -----SIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILD 639
Query: 692 VNGRSTSGMIHACLARLLKELK-GRITLTI 720
VNG G+ K+++ G LT+
Sbjct: 640 VNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
Score = 48.5 bits (114), Expect = 2e-05
Identities = 79/361 (21%), Positives = 129/361 (35%), Gaps = 66/361 (18%)
Query: 163 EVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFK 222
E + S+ PG D P V AE+ + + G + R S +
Sbjct: 457 EEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVE 516
Query: 223 KIN-----------RALSVLRRTK----------SGSAVANHADQGRENSENTTAPEVFP 261
+ N R L V R + S ++ H + S +TT E
Sbjct: 517 EYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVE--- 573
Query: 262 RLYHLIPDGEITSIKINRVDPSESLSIRLVGGSET--PLVHIIIQHIYRDGVIARDGRLL 319
+ LI I+ I + + + + L + GG + + I ++ I+ +G A DGRL
Sbjct: 574 SPWRLIRPSVISIIGLYK-EKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632
Query: 320 PGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQ-------------------- 359
GD IL VNG+ I + A+ +Q L++ +R +
Sbjct: 633 EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692
Query: 360 -KFRSRNNGQAPDAYRPRDDS-------------FHVILNKSSPEEQLGIK---LVRKVD 402
F + A + S V LNK P LGI L +
Sbjct: 693 PNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNK-EPRVGLGIGACCLALENS 751
Query: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA-AHLIQASERRVHLVVS 461
PG++I ++ G VA L D++L +N ++R+ + A L + V LV+
Sbjct: 752 PPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIG 811
Query: 462 R 462
R
Sbjct: 812 R 812
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/240 (22%), Positives = 94/240 (39%), Gaps = 48/240 (20%)
Query: 226 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSES 285
R SVL S S + + + SEN + ++ I +NR + S
Sbjct: 2589 RLQSVLSSVGSKSTILTLIQEAKAQSEN---------------EEDVCFIVLNRKEGS-G 2632
Query: 286 LSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345
L + GG++ I + ++ G +++G + GD +L VNG ++ + H +++L
Sbjct: 2633 LGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLH 2692
Query: 346 Q-PCQVLWLTVMREQKFRSRNNG-QAPDAYRPRDDSFHVILNKSSPEEQ----------- 392
Q L V+++ + R + Q P P + ++ K+ P E
Sbjct: 2693 QAQLHKDALVVIKKGMDQPRPSARQEP----PTANGKGLLSRKTIPLEPGIGRSVAVHDA 2748
Query: 393 -----------LGIKL----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 437
LG+ L + + I V GG A + G +E D +LAING L
Sbjct: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
Score = 43.5 bits (101), Expect = 7e-04
Identities = 22/74 (29%), Positives = 33/74 (44%)
Query: 649 LGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARL 708
LG + GG + + EG A+ DGR+ GD LL +NG G+ H +
Sbjct: 344 LGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAI 403
Query: 709 LKELKGRITLTIVS 722
L+ G + L + S
Sbjct: 404 LRSATGMVQLVVAS 417
Score = 40.8 bits (94), Expect = 0.004
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 2/73 (2%)
Query: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 698
IVL R LGF + GG + K + + A +G + GD LL+VNG S +
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDV--EPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
Query: 699 GMIHACLARLLKE 711
G+ H + ++L +
Sbjct: 2681 GLAHGNVLKVLHQ 2693
Score = 30.4 bits (67), Expect = 6.1
Identities = 22/75 (29%), Positives = 37/75 (49%), Gaps = 6/75 (8%)
Query: 283 SESLSIRLVGG--SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340
S L + L GG S T ++I+ +Y+ G + G + GD IL +NG + + H A
Sbjct: 2757 SAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDA 2816
Query: 341 VRLLRQ----PCQVL 351
+++ P Q+L
Sbjct: 2817 WNIMKSVPEGPVQLL 2831
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 77.4 bits (189), Expect = 4e-14
Identities = 123/547 (22%), Positives = 209/547 (38%), Gaps = 89/547 (16%)
Query: 223 KINRALSVLRRTKSGSAVANHADQGR-ENSENTTAPEVFPRLYHLI--PDGEITSIKINR 279
K+N + SV +S + +D E+ +V + + ++ P+ EIT + + +
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKK 1079
Query: 280 VDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPH 337
D L +++GG + + I I + G DG L PGD ++ VN + + V H
Sbjct: 1080 -DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138
Query: 338 NYAVRLLRQPCQVLWLTVMREQKFRSR------------NNGQAPDAYRPRDDSFHVILN 385
+ A+ +L+ + + L + + ++ S+ N +Y DS ++
Sbjct: 1139 HAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY--MQDS---AID 1193
Query: 386 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEND--------RVLAING--- 434
SS + +R + E N R G L D +NG
Sbjct: 1194 SSSKDHHWSRGTLRHISE------NSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFA 1247
Query: 435 --------HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG 486
+ ++GSP S + + +A+E+ S Q + + P I ++ G
Sbjct: 1248 SHLGDQTWQESQHGSP-SPSVISKATEKET-FTDSNQSKTKKPGISDVTDYSDRGDSDMD 1305
Query: 487 PGERSN-----TPKPLHPTITCHEKVVNIQ------KDPGE-----------SLGMTVAG 524
S+ TPK + +N + PG+ SLG++V G
Sbjct: 1306 EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTG 1365
Query: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSS 584
G + IYV +V P G DGRI GD +L V+GV L + +AV L+ T
Sbjct: 1366 GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQV 1425
Query: 585 IVL-----KALEVKEY---EPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNC 636
+ L ++ KE+ PQ S A + + E N
Sbjct: 1426 VHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTE-----ENT 1480
Query: 637 KDIVLRRNTAGSLGFCIV---GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVN 693
++ L +N++G LGF E +K + G PA G+I GD++L VN
Sbjct: 1481 FEVKLFKNSSG-LGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVN 1539
Query: 694 GRSTSGM 700
G S G+
Sbjct: 1540 GASLKGL 1546
Score = 70.9 bits (172), Expect = 4e-12
Identities = 111/529 (20%), Positives = 199/529 (37%), Gaps = 105/529 (19%)
Query: 270 GEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKV 327
G+I +++ + D SL I + GG T + H I ++ + G DGR+ GD +L V
Sbjct: 1345 GDIFEVELAKND--NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1402
Query: 328 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQAPD- 371
NG+ + H AV LR QV+ L + + Q S+ + GQ P+
Sbjct: 1403 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1462
Query: 372 ----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNVLDG 414
++ +++F V L K+S LG R +++ V + + G
Sbjct: 1463 VKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKLFPG 1520
Query: 415 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1521 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTA 1580
Query: 475 --AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAGGAS 527
S P + S+ P + + + E ++ + K P + + G+
Sbjct: 1581 LLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG 1640
Query: 528 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 587
+ + P + + L N+ VS++++ ++ +
Sbjct: 1641 EDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQEDTIC 1686
Query: 588 KALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM----------- 625
Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1687 TMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEP 1742
Query: 626 -----WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 671
W L L N + I L ++ GSLGF + G N ++ +
Sbjct: 1743 TRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYVHDV 1798
Query: 672 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1799 IQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1846
Score = 47.8 bits (112), Expect = 4e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 388 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 447
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1775 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1833
Query: 448 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 503
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1834 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1869
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1870 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1917
Query: 564 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 619
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1918 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1977
Query: 620 SPS 622
P+
Sbjct: 1978 QPA 1980
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 1077 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1136
Query: 701 IHACLARLLKELKGRITLTI 720
H +L+ +TL I
Sbjct: 1137 SHHAAIEILQNAPEDVTLVI 1156
Score = 47.0 bits (110), Expect = 6e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 482 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 541
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1747 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1799
Query: 542 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 601
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1800 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1853
Query: 602 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 661
+P + DI L N LGF + GG++
Sbjct: 1854 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1886
Query: 662 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1887 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1923
Score = 43.5 bits (101), Expect = 7e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 299 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 358
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1795 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1849
Query: 359 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 413
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1850 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1896
Query: 414 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 473
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1897 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1956
Query: 474 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 505
A NGS+S G + + TP T+ E
Sbjct: 1957 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 1994
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 261 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 320
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1856 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1908
Query: 321 GDIILKVNGM 330
D+I VNG+
Sbjct: 1909 LDVIHYVNGV 1918
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 77.4 bits (189), Expect = 4e-14
Identities = 58/206 (28%), Positives = 96/206 (46%), Gaps = 33/206 (16%)
Query: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 566
VV + K G +LG+T++GG D V ++ PGG+ +R + GD + +V+G+ L
Sbjct: 145 VVELIKKEGSTLGLTISGGTDK---DGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHL 201
Query: 567 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
T + E + LLK +VL+ EYE P A ++N
Sbjct: 202 TRLRHDEIITLLKNVGERVVLEV----EYE-----LPPPAPENN---------------- 236
Query: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 685
PR + D+ L + S GF + GG +E+ + ++P + + G PA +G ++
Sbjct: 237 ---PRIISKTVDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKV 292
Query: 686 GDILLAVNGRSTSGMIHACLARLLKE 711
GD LL+V+G G HA L++
Sbjct: 293 GDRLLSVDGIPLHGASHATALATLRQ 318
Score = 70.1 bits (170), Expect = 7e-12
Identities = 90/331 (27%), Positives = 136/331 (41%), Gaps = 52/331 (15%)
Query: 268 PDGEITSIKINRV----DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLP 320
P G+I + V DP ++L GG +ET ++ I D R G L
Sbjct: 543 PGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQV 602
Query: 321 GDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSF 380
GD +L +NG+ + A +LLR L V+ E +F ++ P +F
Sbjct: 603 GDRVLSINGIATEDGTMEEANQLLRD--AALAHKVVLEVEF------DVAESVIPSSGTF 654
Query: 381 HVILNKSSPEEQLGIKL---VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDL 437
HV L K E LGI + RK EP + I ++ G VA+R G LE D++LAI+ L
Sbjct: 655 HVKLPKKRSVE-LGITISSASRKRGEP-LIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
Query: 438 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 497
E A +++ E V L + + N G S T +
Sbjct: 713 DNCPMEDAVQILRQCEDLVKLKIRKD--------------EDNSDELETTGAVSYTVE-- 756
Query: 498 HPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDI 557
K G LG+T++G + +D PI + + G+ R G I GD
Sbjct: 757 -------------LKRYGGPLGITISG--TEEPFD-PIVISGLTKRGLAERTGAIHVGDR 800
Query: 558 LLNVDGVELTEVSRSEAVALLKRTSSSIVLK 588
+L ++ V L SEA+ LL+ ++ LK
Sbjct: 801 ILAINNVSLKGRPLSEAIHLLQVAGETVTLK 831
Score = 65.5 bits (158), Expect = 2e-10
Identities = 79/330 (23%), Positives = 127/330 (38%), Gaps = 49/330 (14%)
Query: 303 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 362
+ ++ G+ AR L GD I VNG+ ++ + H+ + LL+ + + L V E
Sbjct: 172 VSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPP 231
Query: 363 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPG-----VFIFNVLDGGVA 417
+ N PR S V ++ G L E G + + V GG A
Sbjct: 232 APENN-------PRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPA 284
Query: 418 YRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGW 477
R G L+ DR+L+++G L S +A ++ V V
Sbjct: 285 DREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVAT----------- 333
Query: 478 NSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYV 537
P +N PL +V I K PG +LG+++ + + I +
Sbjct: 334 ---------PDTVANASGPL---------MVEIVKTPGSALGISLTTTSLRNK--SVITI 373
Query: 538 ISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE- 596
++P V+ R G + GD +L++DG + S EA LL S + L+ L V + +
Sbjct: 374 DRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQR 433
Query: 597 ---PQEDCSSPAALDSNHNMAP--PSDWSP 621
PQ + H P PS SP
Sbjct: 434 PLRPQRQVVKVQRSEQLHRWDPCVPSCHSP 463
Score = 59.3 bits (142), Expect = 1e-08
Identities = 57/215 (26%), Positives = 92/215 (42%), Gaps = 46/215 (21%)
Query: 386 KSSPEEQLGIKLVRKVDEPGVF----------------IFNVLDGGVAYRHGQLEENDRV 429
+S PEE GI +V + + G + N+ GG+A R L D +
Sbjct: 134 QSIPEEFRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYI 193
Query: 430 LAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGE 489
++NG L + L++ RV L V ++ +P+
Sbjct: 194 RSVNGIHLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPE------------------- 234
Query: 490 RSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREW--DLPIYVISVEPGGVIS 547
N P+ + T+ V++ K+ G S G + GGA H + P+ + V PGG
Sbjct: 235 --NNPRIISKTVD-----VSLYKE-GNSFGFVLRGGA-HEDGHKSRPLVLTYVRPGGPAD 285
Query: 548 RDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTS 582
R+G +K GD LL+VDG+ L S + A+A L++ S
Sbjct: 286 REGSLKVGDRLLSVDGIPLHGASHATALATLRQCS 320
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/199 (25%), Positives = 88/199 (44%), Gaps = 9/199 (4%)
Query: 266 LIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 325
+IP +K+ + S L I + S +II I + V R G L PGD +L
Sbjct: 647 VIPSSGTFHVKLPK-KRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLL 705
Query: 326 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN 385
++ + + N P AV++LRQ ++ L + +++ + + S+ V L
Sbjct: 706 AIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDE-------DNSDELETTGAVSYTVELK 758
Query: 386 KSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESA 445
+ + I + +P + I + G+A R G + DR+LAIN L+ A
Sbjct: 759 RYGGPLGITISGTEEPFDP-IVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEA 817
Query: 446 AHLIQASERRVHLVVSRQV 464
HL+Q + V L + +Q+
Sbjct: 818 IHLLQVAGETVTLKIKKQL 836
Score = 44.3 bits (103), Expect = 4e-04
Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 11/162 (6%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
+++ ++ G R+G L GD +L V+G+ + H A+ LRQ E
Sbjct: 273 LVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------CSHEAL 324
Query: 361 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 418
F+ + PD V + K +P LGI L ++ + I + V
Sbjct: 325 FQVEYDVATPDTVANASGPLMVEIVK-TPGSALGISLTTTSLRNKSVITIDRIKPASVVD 383
Query: 419 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV 460
R G L D +L+I+G + + S A L+ + +V L +
Sbjct: 384 RSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
Score = 37.4 bits (85), Expect = 0.050
Identities = 91/443 (20%), Positives = 152/443 (34%), Gaps = 63/443 (14%)
Query: 282 PSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAV 341
P +L I L S I I I V+ R G L PGD IL ++G + + A
Sbjct: 352 PGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEAT 411
Query: 342 RLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV 401
+LL + + L ++ P + RP V+ + S + V
Sbjct: 412 KLLASISEKVRLEIL-----------PVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSC 460
Query: 402 DEPGVFIFNVLDGGVAYRHGQ---LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHL 458
P + Q L H +P + Q R +
Sbjct: 461 HSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRTTM 520
Query: 459 VVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESL 518
RQ R+ S S + GPG + +H T V + DP
Sbjct: 521 GRRRQRRREHKSSL------SLASSTVGPGGQI-----VHTETT----EVVLCGDPLSGF 565
Query: 519 GMTVAGGASHRE-WDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVAL 577
G+ + GG E P V +EP R G ++ GD +L+++G+ + + EA L
Sbjct: 566 GLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQL 625
Query: 578 LKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCK 637
L+ +++ K + E++ E PS S ++LP
Sbjct: 626 LR--DAALAHKVVLEVEFDVAES-------------VIPS----SGTFHVKLP------- 659
Query: 638 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697
+ + LG I + +P I I +G+ A+ G + GD LLA++
Sbjct: 660 -----KKRSVELGITISSASRK--RGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRL 712
Query: 698 SGMIHACLARLLKELKGRITLTI 720
++L++ + + L I
Sbjct: 713 DNCPMEDAVQILRQCEDLVKLKI 735
Score = 30.8 bits (68), Expect = 4.6
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 10/106 (9%)
Query: 382 VILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 441
V L+K G + + E GV++ V G A+R G L+ DRVL +N R
Sbjct: 1040 VTLHKDPMRHDFGFSVSDGLLEKGVYVHTVRPDGPAHR-GGLQPFDRVLQVNHVRTRDFD 1098
Query: 442 PESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGP 487
A L+ + + L++SR+ +S SPGP
Sbjct: 1099 CCLAVPLLAEAGDVLELIISRK---------PHTAHSSRAPRSPGP 1135
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 77.0 bits (188), Expect = 6e-14
Identities = 117/523 (22%), Positives = 203/523 (38%), Gaps = 88/523 (16%)
Query: 246 QGRENSENTTAPEVFPRLYHLI--PDGEITSIKINRVDPSESLSIRLVGGSETPLVH--I 301
+ R+++++ +V + + ++ P+ EIT + + + D L +++GG + + I
Sbjct: 872 RARQSNQDAQDIDVLHKRWSIVSSPEREITLVNLKK-DAKYGLGFQIIGGEKMGRLDLGI 930
Query: 302 IIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKF 361
I + G DG L PGD ++ VN + + V H+ A+ +L+ + + L + + ++
Sbjct: 931 FISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEK 990
Query: 362 RSR------------NNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIF 409
S+ N +Y DS ++ SS + +R + E
Sbjct: 991 ISKVPSTPVHLTNEMKNYMKKSSY--MQDS---AIDSSSKDHHWSRGTLRHISE------ 1039
Query: 410 NVLDGGVAYRHGQLEEND--------RVLAING-----------HDLRYGSPESAAHLIQ 450
N R G L D +NG + ++GSP S + + +
Sbjct: 1040 NSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSP-SPSVISK 1098
Query: 451 ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSN-----TPKPLHPTITCHE 505
A+E+ S Q + + P I ++ G S+ TPK +
Sbjct: 1099 ATEKET-FTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTS 1157
Query: 506 KVVNIQ------KDPGE-----------SLGMTVAGGASHREWDLPIYVISVEPGGVISR 548
+N + PG+ SLG++V GG + IYV +V P G
Sbjct: 1158 NKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAES 1217
Query: 549 DGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL-----KALEVKEY---EPQED 600
DGRI GD +L V+GV L + +AV L+ T + L ++ KE+ PQ
Sbjct: 1218 DGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT 1277
Query: 601 CSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV---GGY 657
S A + + E N ++ L +N++G LGF
Sbjct: 1278 LSDQNAQGQGPEKVKKTTQVKDYSFVTE-----ENTFEVKLFKNSSG-LGFSFSREDNLI 1331
Query: 658 EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
E +K + G PA G+I GD++L VNG S G+
Sbjct: 1332 PEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGL 1374
Score = 70.9 bits (172), Expect = 4e-12
Identities = 111/529 (20%), Positives = 199/529 (37%), Gaps = 105/529 (19%)
Query: 270 GEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKV 327
G+I +++ + D SL I + GG T + H I ++ + G DGR+ GD +L V
Sbjct: 1173 GDIFEVELAKND--NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1230
Query: 328 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQAPD- 371
NG+ + H AV LR QV+ L + + Q S+ + GQ P+
Sbjct: 1231 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1290
Query: 372 ----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNVLDG 414
++ +++F V L K+S LG R +++ V + + G
Sbjct: 1291 VKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKLFPG 1348
Query: 415 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1349 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTA 1408
Query: 475 --AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAGGAS 527
S P + S+ P + + + E ++ + K P + + G+
Sbjct: 1409 LLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG 1468
Query: 528 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 587
+ + P + + L N+ VS++++ ++ +
Sbjct: 1469 EDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQEDTIC 1514
Query: 588 KALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM----------- 625
Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1515 TMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEP 1570
Query: 626 -----WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 671
W L L N + I L ++ GSLGF + G N ++ +
Sbjct: 1571 TRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYVHDV 1626
Query: 672 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1627 IQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1674
Score = 47.8 bits (112), Expect = 4e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 388 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 447
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1603 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1661
Query: 448 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 503
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1662 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1697
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1698 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1745
Query: 564 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 619
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1746 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1805
Query: 620 SPS 622
P+
Sbjct: 1806 QPA 1808
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 905 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964
Query: 701 IHACLARLLKELKGRITLTI 720
H +L+ +TL I
Sbjct: 965 SHHAAIEILQNAPEDVTLVI 984
Score = 47.0 bits (110), Expect = 6e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 482 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 541
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1575 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1627
Query: 542 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 601
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1628 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1681
Query: 602 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 661
+P + DI L N LGF + GG++
Sbjct: 1682 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1714
Query: 662 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1715 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1751
Score = 43.5 bits (101), Expect = 7e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 299 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 358
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1623 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1677
Query: 359 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 413
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1678 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1724
Query: 414 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 473
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1725 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1784
Query: 474 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 505
A NGS+S G + + TP T+ E
Sbjct: 1785 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 1822
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 261 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 320
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1684 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1736
Query: 321 GDIILKVNGM 330
D+I VNG+
Sbjct: 1737 LDVIHYVNGV 1746
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 75.5 bits (184), Expect = 2e-13
Identities = 115/499 (23%), Positives = 190/499 (38%), Gaps = 86/499 (17%)
Query: 268 PDGEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIIL 325
P+ EIT + + + D L +++GG + + I I + G DG L PGD ++
Sbjct: 1087 PEREITLVNLKK-DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 326 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSR------------NNGQAPDAY 373
VN + + V H+ A+ +L+ + + L + + ++ S+ N +Y
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY 1205
Query: 374 RPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEND------ 427
DS ++ SS + +R + E N R G L D
Sbjct: 1206 --MQDS---AIDSSSKDHHWSRGTLRHISE------NSFGPSGGLREGSLSSQDSRTESA 1254
Query: 428 --RVLAING-----------HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
+NG + ++GSP S + + +A+E+ S Q + + P I
Sbjct: 1255 SLSQSQVNGFFASHLGDQTWQESQHGSP-SPSVISKATEKET-FTDSNQSKTKKPGISDV 1312
Query: 475 AGWNSNGSWSPGPGERSN-----TPKPLHPTITCHEKVVNIQ------KDPGE------- 516
++ G S+ TPK + +N + PG+
Sbjct: 1313 TDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELA 1372
Query: 517 ----SLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 572
SLG++V GG + IYV +V P G DGRI GD +L V+GV L +
Sbjct: 1373 KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1432
Query: 573 EAVALLKRTSSSIVL-----KALEVKEY---EPQEDCSSPAALDSNHNMAPPSDWSPSWV 624
+AV L+ T + L ++ KE+ PQ S A + +
Sbjct: 1433 QAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS 1492
Query: 625 MWLELPRCLYNCKDIVLRRNTAGSLGFCIV---GGYEEYNGNKPFFIKSIVEGTPAYNDG 681
E N ++ L +N++G LGF E +K + G PA G
Sbjct: 1493 FVTE-----ENTFEVKLFKNSSG-LGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546
Query: 682 RIRCGDILLAVNGRSTSGM 700
+I GD++L VNG S G+
Sbjct: 1547 KIDVGDVILKVNGASLKGL 1565
Score = 70.9 bits (172), Expect = 4e-12
Identities = 111/529 (20%), Positives = 199/529 (37%), Gaps = 105/529 (19%)
Query: 270 GEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIILKV 327
G+I +++ + D SL I + GG T + H I ++ + G DGR+ GD +L V
Sbjct: 1364 GDIFEVELAKND--NSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAV 1421
Query: 328 NGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQAPD- 371
NG+ + H AV LR QV+ L + + Q S+ + GQ P+
Sbjct: 1422 NGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEK 1481
Query: 372 ----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNVLDG 414
++ +++F V L K+S LG R +++ V + + G
Sbjct: 1482 VKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKLFPG 1539
Query: 415 GVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1540 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTA 1599
Query: 475 --AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAGGAS 527
S P + S+ P + + + E ++ + K P + + G+
Sbjct: 1600 LLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG 1659
Query: 528 HREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL 587
+ + P + + L N+ VS++++ ++ +
Sbjct: 1660 EDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQEDTIC 1705
Query: 588 KALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM----------- 625
Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1706 TMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEP 1761
Query: 626 -----WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSI 671
W L L N + I L ++ GSLGF + G N ++ +
Sbjct: 1762 TRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYVHDV 1817
Query: 672 VEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1818 IQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1865
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 20/169 (11%)
Query: 438 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 497
+ + +S A L ++ ERR H S + +S+G+ S++ PL
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGN--------SSSQVPL 1071
Query: 498 HPTITCHEK------------VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGV 545
H++ +VN++KD LG + GG DL I++ SV PGG
Sbjct: 1072 KENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1131
Query: 546 ISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 594
DG +K GD L++V+ V L VS A+ +L+ + L + KE
Sbjct: 1132 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 47.8 bits (112), Expect = 4e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 388 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 447
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1794 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1852
Query: 448 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 503
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1853 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1888
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1889 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1936
Query: 564 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 619
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1937 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1996
Query: 620 SPS 622
P+
Sbjct: 1997 QPA 1999
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 701 IHACLARLLKELKGRITLTI 720
H +L+ +TL I
Sbjct: 1156 SHHAAIEILQNAPEDVTLVI 1175
Score = 47.0 bits (110), Expect = 6e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 482 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 541
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1766 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1818
Query: 542 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 601
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1819 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1872
Query: 602 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 661
+P + DI L N LGF + GG++
Sbjct: 1873 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1905
Query: 662 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1906 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1942
Score = 43.5 bits (101), Expect = 7e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 299 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 358
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1814 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1868
Query: 359 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 413
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1869 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1915
Query: 414 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 473
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1916 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1975
Query: 474 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 505
A NGS+S G + + TP T+ E
Sbjct: 1976 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 2013
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 261 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 320
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1875 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1927
Query: 321 GDIILKVNGM 330
D+I VNG+
Sbjct: 1928 LDVIHYVNGV 1937
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 74.3 bits (181), Expect = 4e-13
Identities = 91/345 (26%), Positives = 143/345 (41%), Gaps = 52/345 (15%)
Query: 281 DPSESLSIRLVGG---SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPH 337
DP I+L G +ET +I +I D R G L GD ++ +NG+ +
Sbjct: 426 DPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTF 485
Query: 338 NYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKL 397
A +LLR +T+ E +F ++ P +FHV L K E LGI +
Sbjct: 486 EEASQLLRDSSITSKVTL--EIEF------DVAESVIPSSGTFHVKLPKKHNVE-LGITI 536
Query: 398 ----VRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASE 453
RK +P + I ++ G VA+R G LE D++LAI+ L S E A ++Q E
Sbjct: 537 SSPSSRKPGDP-LVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE 595
Query: 454 RRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKD 513
V L + + N G T + K
Sbjct: 596 DLVKLKIRKD--------------EDNSDEQESSGAIIYTVE---------------LKR 626
Query: 514 PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSE 573
G LG+T++G + +D PI + S+ GG+ R G I GD +L ++ L SE
Sbjct: 627 YGGPLGITISG--TEEPFD-PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSE 683
Query: 574 AVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSD 618
A+ LL+ ++ LK +K+ + SSP + +++ D
Sbjct: 684 AIHLLQMAGETVTLK---IKKQTDAQSASSPKKFPISSHLSDLGD 725
Score = 73.6 bits (179), Expect = 6e-13
Identities = 60/215 (27%), Positives = 96/215 (44%), Gaps = 34/215 (15%)
Query: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVEL 566
VV + K G +LG+TV+GG D V ++ GG+ +R ++ GD + V+G+ L
Sbjct: 53 VVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINL 109
Query: 567 TEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMW 626
+ E ++LLK +VL+ EYE PP S V
Sbjct: 110 AKFRHDEIISLLKNVGERVVLEV----EYE-----------------LPPVSVQGSSV-- 146
Query: 627 LELPRCLYNCKDIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYNDGRIRC 685
++ ++ L + + GF I GG +++ N ++P I + G PA +G I+
Sbjct: 147 ------IFRTVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKP 199
Query: 686 GDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
GD LL+V+G G HA +LK+ L I
Sbjct: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234
Score = 67.4 bits (163), Expect = 4e-11
Identities = 75/304 (24%), Positives = 122/304 (40%), Gaps = 64/304 (21%)
Query: 417 AYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAG 476
A R G L+ DRV+AING + E A+ L++ S + S+ + D+ +
Sbjct: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-----ITSKVTLEIEFDVAE--- 511
Query: 477 WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIY 536
S P G T H V + K LG+T++ +S + D P+
Sbjct: 512 -----SVIPSSG-------------TFH---VKLPKKHNVELGITISSPSSRKPGD-PLV 549
Query: 537 VISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYE 596
+ ++ G V R G ++ GD LL +D + L S +AV +L++ + LK + ++
Sbjct: 550 ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNS 609
Query: 597 PQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGG 656
+++ S + +EL R G LG I G
Sbjct: 610 DEQESSGAI------------------IYTVELKRY-------------GGPLGITISGT 638
Query: 657 YEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRI 716
E ++ P I S+ +G A G I GD +LA+N S G + LL+ +
Sbjct: 639 EEPFD---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETV 695
Query: 717 TLTI 720
TL I
Sbjct: 696 TLKI 699
Score = 60.5 bits (145), Expect = 5e-09
Identities = 94/462 (20%), Positives = 176/462 (38%), Gaps = 80/462 (17%)
Query: 303 IQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFR 362
+ ++ + G+ AR +L GD I VNG++++ H+ + LL+ + + L V E
Sbjct: 80 VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139
Query: 363 SRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQ 422
S +R + + H N + G R P V I V GG A R G
Sbjct: 140 SVQGSSV--IFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRP-VVITCVRPGGPADREGT 196
Query: 423 LEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGS 482
++ DR+L+++G L + A +++ + L++ V + +
Sbjct: 197 IKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMD-----------SVA 245
Query: 483 WSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEP 542
+ GP +V + K PG SLG+ + + I + ++
Sbjct: 246 TASGP------------------LLVEVAKTPGASLGVALTTSMCCNKQ--VIVIDKIKS 285
Query: 543 GGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS 602
+ R G + GD +L++DG + + +EA L T+ + L+ L ++ +
Sbjct: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEIL--PHHQTRLALK 343
Query: 603 SP---AALDSNHNMAPPSDWSPSWVMWLELPRCLYNCK---------------------- 637
P A + S+ + S +S S + LPR LY+
Sbjct: 344 GPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLA 403
Query: 638 ----------------DIVLRRNTAGSLGFCIVGG-YEEYNGNKPFFIKSIVEGTPAYND 680
++VL + G + G + + P I I +PA
Sbjct: 404 SSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERC 463
Query: 681 GRIRCGDILLAVNGRSTSGMIHACLARLLKE--LKGRITLTI 720
G ++ GD ++A+NG T ++LL++ + ++TL I
Sbjct: 464 GVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI 505
Score = 46.6 bits (109), Expect = 8e-05
Identities = 90/464 (19%), Positives = 166/464 (35%), Gaps = 85/464 (18%)
Query: 301 IIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQK 360
++I + G R+G + PGD +L V+G+ + H A+ +L+Q Q L +
Sbjct: 180 VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI----- 234
Query: 361 FRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKV--DEPGVFIFNVLDGGVAY 418
+ D+ V + K +P LG+ L + ++ + I + +A
Sbjct: 235 ---EYDVSVMDSVATASGPLLVEVAK-TPGASLGVALTTSMCCNKQVIVIDKIKSASIAD 290
Query: 419 RHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVV----SRQVRQRSPD---- 470
R G L D +L+I+G + Y + A + + +V L + ++ + PD
Sbjct: 291 RCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAAL 350
Query: 471 IFQEAGWNSNGSWSPGPGERSNTPKPLHPT------------------------------ 500
+ S ++S P+ L+ T
Sbjct: 351 VSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLA 410
Query: 501 ---ITCHEKVVNIQKDPGESLGMTVAGGASHRE-WDLPIYVISVEPGGVISRDGRIKTGD 556
+ V + DP G+ + G E P + +E R G ++ GD
Sbjct: 411 GQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGD 470
Query: 557 ILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPP 616
++ ++G+ TE S E + L R SS LE++ D ++ P
Sbjct: 471 RVMAINGIP-TEDSTFEEASQLLRDSSITSKVTLEIE-------------FDVAESVIPS 516
Query: 617 SDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTP 676
S ++LP+ + N LG I G+ P I I +G+
Sbjct: 517 SG-----TFHVKLPK----------KHNV--ELGITISSPSSRKPGD-PLVISDIKKGSV 558
Query: 677 AYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
A+ G + GD LLA++ ++L++ + + L I
Sbjct: 559 AHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 71.2 bits (173), Expect = 3e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 16/210 (7%)
Query: 519 GMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
G V GG D IY+ ++ P G +DGR++ D L+ +DG+ + S + + L+
Sbjct: 737 GFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
Query: 579 KRTSSS-----IVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCL 633
+ + V + + E +P++D S A S N +P + + V P+
Sbjct: 794 TTAARNGHVLLTVRRKIFYGEKQPEDDSSQ--AFISTQNGSPRLNRAE--VPARPAPQEP 849
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEEYN-GNKPFFIKSIVEGTPAYNDGRIRCGDILLAV 692
Y D+VL+R GF I+ + G P I ++EG+PA G+++ GD + AV
Sbjct: 850 Y---DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 693 NGRSTSGMIHACLARLLKELKGRITLTIVS 722
NG+S + H + +L+K+ +TLT+++
Sbjct: 907 NGQSIVELSHDNIVQLIKDAGVTVTLTVIA 936
Score = 69.3 bits (168), Expect = 1e-11
Identities = 86/371 (23%), Positives = 142/371 (38%), Gaps = 57/371 (15%)
Query: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVH--LVV 460
+ ++I ++ G A + G+L D ++ I+G ++ S + L+ + R H L V
Sbjct: 747 DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTV 806
Query: 461 SRQV----RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 516
R++ +Q D Q NGS E P P P V +Q+ E
Sbjct: 807 RRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD------VVLQRKENE 860
Query: 517 SLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
G + + +P + V G R G++K GD + V+G + E+S V
Sbjct: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIV 920
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPA------------------------ALDSNH 611
L+K ++ L + +E+ ++ A AL+
Sbjct: 921 QLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEI 980
Query: 612 NMAPPSDWSPSWVMWLELPR----------CLYN----CKDIVLRRNTAGSLGFCIVGGY 657
+ + SW L + +N C + L R G GF + GG
Sbjct: 981 GKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGG- 1038
Query: 658 EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRIT 717
+EYN FI + E PA DGRI GD ++ +NG T G+ H L++ ++
Sbjct: 1039 KEYNMG--LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096
Query: 718 LTIVSWPGTFL 728
L + PGT L
Sbjct: 1097 LLL--RPGTGL 1105
Score = 58.5 bits (140), Expect = 2e-08
Identities = 75/375 (20%), Positives = 147/375 (39%), Gaps = 92/375 (24%)
Query: 289 RLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPC 348
R++GG + P I I I G +DGRL D ++ ++G+ + H + L+
Sbjct: 739 RVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
Query: 349 QV--LWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN---------------KSSPEE 391
+ + LTV R+ + + +P DDS ++ + +P+E
Sbjct: 798 RNGHVLLTVRRKIFYGEK---------QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQE 848
Query: 392 QLGIKLVRKVDE--------------PGVF---IFNVLDGGVAYRHGQLEENDRVLAING 434
+ L RK +E PGV I V++G A R G+L+ D + A+NG
Sbjct: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
Query: 435 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSP------------------------- 469
+ S ++ LI+ + V L V + P
Sbjct: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
Query: 470 ----------DIFQEAGWNSNGSWS-------PGPGERSNTPKPLHPTITCHEKVVNIQK 512
+I ++ + SWS P S + + C+ V +++
Sbjct: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP--VELER 1026
Query: 513 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 572
P G ++ GG +E+++ ++++ + G +DGRI GD ++ ++G ++ +
Sbjct: 1027 GP-RGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHT 1082
Query: 573 EAVALLKRTSSSIVL 587
A+ L++ + ++L
Sbjct: 1083 RAIELIQAGGNKVLL 1097
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 4/70 (5%)
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
L+++T G GF I+GG ++ +K++++ PA DG+I GD+++ +NG G
Sbjct: 413 LKKSTMG-FGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
Query: 701 IHACLARLLK 710
HA + ++ +
Sbjct: 469 THADVVQMFQ 478
Score = 38.5 bits (88), Expect = 0.022
Identities = 15/53 (28%), Positives = 32/53 (60%)
Query: 293 GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345
G + P + ++++ +DG A+DG++ PGD+I+ +NG + H V++ +
Sbjct: 426 GGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
Score = 35.0 bits (79), Expect = 0.25
Identities = 32/140 (22%), Positives = 52/140 (37%), Gaps = 21/140 (15%)
Query: 226 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYH--------LIPDGEITSIKI 277
R L+ G + ANH R E +V H PD + S+
Sbjct: 951 RQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVG 1010
Query: 278 NRVDPS------------ESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 325
+R + + L GG E + + I + DG +DGR+ GD I+
Sbjct: 1011 SRHNQNLGCYPVELERGPRGFGFSLRGGKEYNM-GLFILRLAEDGPAIKDGRIHVGDQIV 1069
Query: 326 KVNGMDISNVPHNYAVRLLR 345
++NG + H A+ L++
Sbjct: 1070 EINGEPTQGITHTRAIELIQ 1089
Score = 30.4 bits (67), Expect = 6.1
Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 7/101 (6%)
Query: 495 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGG----VISRDG 550
K H E V+ PG+ G + GGA E+ + + EPGG V+S
Sbjct: 7 KKKHWLSKVQECAVSWAGPPGD-FGAEIRGGAERGEFPY-LGRLREEPGGGTCCVVSGKA 64
Query: 551 RIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALE 591
GD+LL V+G ++ ++ + +A+++ I LK ++
Sbjct: 65 P-SPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 71.2 bits (173), Expect = 3e-12
Identities = 58/210 (27%), Positives = 103/210 (49%), Gaps = 16/210 (7%)
Query: 519 GMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALL 578
G V GG D IY+ ++ P G +DGR++ D L+ +DG+ + S + + L+
Sbjct: 737 GFRVLGGDGP---DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLM 793
Query: 579 KRTSSS-----IVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCL 633
+ + V + + E +P++D S A S N +P + + V P+
Sbjct: 794 TTAARNGHVLLTVRRKIFYGEKQPEDDSSQ--AFISTQNGSPRLNRAE--VPARPAPQEP 849
Query: 634 YNCKDIVLRRNTAGSLGFCIVGGYEEYN-GNKPFFIKSIVEGTPAYNDGRIRCGDILLAV 692
Y D+VL+R GF I+ + G P I ++EG+PA G+++ GD + AV
Sbjct: 850 Y---DVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAV 906
Query: 693 NGRSTSGMIHACLARLLKELKGRITLTIVS 722
NG+S + H + +L+K+ +TLT+++
Sbjct: 907 NGQSIVELSHDNIVQLIKDAGVTVTLTVIA 936
Score = 69.3 bits (168), Expect = 1e-11
Identities = 86/371 (23%), Positives = 142/371 (38%), Gaps = 57/371 (15%)
Query: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVH--LVV 460
+ ++I ++ G A + G+L D ++ I+G ++ S + L+ + R H L V
Sbjct: 747 DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTV 806
Query: 461 SRQV----RQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGE 516
R++ +Q D Q NGS E P P P V +Q+ E
Sbjct: 807 RRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYD------VVLQRKENE 860
Query: 517 SLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAV 575
G + + +P + V G R G++K GD + V+G + E+S V
Sbjct: 861 GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIV 920
Query: 576 ALLKRTSSSIVLKALEVKEYEPQEDCSSPA------------------------ALDSNH 611
L+K ++ L + +E+ ++ A AL+
Sbjct: 921 QLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEI 980
Query: 612 NMAPPSDWSPSWVMWLELPR----------CLYN----CKDIVLRRNTAGSLGFCIVGGY 657
+ + SW L + +N C + L R G GF + GG
Sbjct: 981 GKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRG-FGFSLRGG- 1038
Query: 658 EEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRIT 717
+EYN FI + E PA DGRI GD ++ +NG T G+ H L++ ++
Sbjct: 1039 KEYNMG--LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVL 1096
Query: 718 LTIVSWPGTFL 728
L + PGT L
Sbjct: 1097 LLL--RPGTGL 1105
Score = 58.5 bits (140), Expect = 2e-08
Identities = 75/375 (20%), Positives = 147/375 (39%), Gaps = 92/375 (24%)
Query: 289 RLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPC 348
R++GG + P I I I G +DGRL D ++ ++G+ + H + L+
Sbjct: 739 RVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAA 797
Query: 349 QV--LWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILN---------------KSSPEE 391
+ + LTV R+ + + +P DDS ++ + +P+E
Sbjct: 798 RNGHVLLTVRRKIFYGEK---------QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQE 848
Query: 392 QLGIKLVRKVDE--------------PGVF---IFNVLDGGVAYRHGQLEENDRVLAING 434
+ L RK +E PGV I V++G A R G+L+ D + A+NG
Sbjct: 849 PYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNG 908
Query: 435 HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSP------------------------- 469
+ S ++ LI+ + V L V + P
Sbjct: 909 QSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH 968
Query: 470 ----------DIFQEAGWNSNGSWS-------PGPGERSNTPKPLHPTITCHEKVVNIQK 512
+I ++ + SWS P S + + C+ V +++
Sbjct: 969 IPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYP--VELER 1026
Query: 513 DPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRS 572
P G ++ GG +E+++ ++++ + G +DGRI GD ++ ++G ++ +
Sbjct: 1027 GP-RGFGFSLRGG---KEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHT 1082
Query: 573 EAVALLKRTSSSIVL 587
A+ L++ + ++L
Sbjct: 1083 RAIELIQAGGNKVLL 1097
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/70 (30%), Positives = 41/70 (58%), Gaps = 4/70 (5%)
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
L+++T G GF I+GG ++ +K++++ PA DG+I GD+++ +NG G
Sbjct: 413 LKKSTMG-FGFTIIGGDRP---DEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468
Query: 701 IHACLARLLK 710
HA + ++ +
Sbjct: 469 THADVVQMFQ 478
Score = 38.5 bits (88), Expect = 0.022
Identities = 15/53 (28%), Positives = 32/53 (60%)
Query: 293 GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLR 345
G + P + ++++ +DG A+DG++ PGD+I+ +NG + H V++ +
Sbjct: 426 GGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQ 478
Score = 35.0 bits (79), Expect = 0.25
Identities = 32/140 (22%), Positives = 52/140 (37%), Gaps = 21/140 (15%)
Query: 226 RALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYH--------LIPDGEITSIKI 277
R L+ G + ANH R E +V H PD + S+
Sbjct: 951 RQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVG 1010
Query: 278 NRVDPS------------ESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIIL 325
+R + + L GG E + + I + DG +DGR+ GD I+
Sbjct: 1011 SRHNQNLGCYPVELERGPRGFGFSLRGGKEYNM-GLFILRLAEDGPAIKDGRIHVGDQIV 1069
Query: 326 KVNGMDISNVPHNYAVRLLR 345
++NG + H A+ L++
Sbjct: 1070 EINGEPTQGITHTRAIELIQ 1089
Score = 30.4 bits (67), Expect = 6.1
Identities = 27/101 (26%), Positives = 47/101 (46%), Gaps = 7/101 (6%)
Query: 495 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGG----VISRDG 550
K H E V+ PG+ G + GGA E+ + + EPGG V+S
Sbjct: 7 KKKHWLSKVQECAVSWAGPPGD-FGAEIRGGAERGEFPY-LGRLREEPGGGTCCVVSGKA 64
Query: 551 RIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALE 591
GD+LL V+G ++ ++ + +A+++ I LK ++
Sbjct: 65 P-SPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVK 104
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 69.3 bits (168), Expect = 1e-11
Identities = 115/504 (22%), Positives = 190/504 (37%), Gaps = 91/504 (18%)
Query: 268 PDGEITSIKINRVDPSESLSIRLVGGSETPLVH--IIIQHIYRDGVIARDGRLLPGDIIL 325
P+ EIT + + + D L +++GG + + I I + G DG L PGD ++
Sbjct: 1087 PEREITLVNLKK-DAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLI 1145
Query: 326 KVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSR------------NNGQAPDAY 373
VN + + V H+ A+ +L+ + + L + + ++ S+ N +Y
Sbjct: 1146 SVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSY 1205
Query: 374 RPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEND------ 427
DS ++ SS + +R + E N R G L D
Sbjct: 1206 --MQDS---AIDSSSKDHHWSRGTLRHISE------NSFGPSGGLREGSLSSQDSRTESA 1254
Query: 428 --RVLAING-----------HDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQE 474
+NG + ++GSP S + + +A+E+ S Q + + P I
Sbjct: 1255 SLSQSQVNGFFASHLGDQTWQESQHGSP-SPSVISKATEKET-FTDSNQSKTKKPGISDV 1312
Query: 475 AGWNSNGSWSPGPGERSN-----TPKPLHPTITCHEKVVNIQ------KDPGE------- 516
++ G S+ TPK + +N + PG+
Sbjct: 1313 TDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELA 1372
Query: 517 ----SLGMTVA-----GGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELT 567
SLG++V GG + IYV +V P G DGRI GD +L V+GV L
Sbjct: 1373 KNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1432
Query: 568 EVSRSEAVALLKRTSSSIVL-----KALEVKEY---EPQEDCSSPAALDSNHNMAPPSDW 619
+ +AV L+ T + L ++ KE+ PQ S A +
Sbjct: 1433 GATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQ 1492
Query: 620 SPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV---GGYEEYNGNKPFFIKSIVEGTP 676
+ E N ++ L +N++G LGF E +K + G P
Sbjct: 1493 VKDYSFVTE-----ENTFEVKLFKNSSG-LGFSFSREDNLIPEQINASIVRVKKLFPGQP 1546
Query: 677 AYNDGRIRCGDILLAVNGRSTSGM 700
A G+I GD++L VNG S G+
Sbjct: 1547 AAESGKIDVGDVILKVNGASLKGL 1570
Score = 69.3 bits (168), Expect = 1e-11
Identities = 110/532 (20%), Positives = 201/532 (37%), Gaps = 106/532 (19%)
Query: 270 GEITSIKINRVDPSESLSIRLV---GGSETPLVH--IIIQHIYRDGVIARDGRLLPGDII 324
G+I +++ + D S +S+ ++ GG T + H I ++ + G DGR+ GD +
Sbjct: 1364 GDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRV 1423
Query: 325 LKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN---------------GQA 369
L VNG+ + H AV LR QV+ L + + Q S+ + GQ
Sbjct: 1424 LAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQG 1483
Query: 370 PD-----------AYRPRDDSFHVILNKSSPEEQLGIKLVR-------KVDEPGVFIFNV 411
P+ ++ +++F V L K+S LG R +++ V + +
Sbjct: 1484 PEKVKKTTQVKDYSFVTEENTFEVKLFKNS--SGLGFSFSREDNLIPEQINASIVRVKKL 1541
Query: 412 LDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDI 471
G A G+++ D +L +NG L+ S + ++ + V L++ R P+I
Sbjct: 1542 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1601
Query: 472 FQE--AGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQ-----KDPGESLGMTVAG 524
S P + S+ P + + + E ++ + K P + +
Sbjct: 1602 DTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSS 1661
Query: 525 GASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSS 584
G+ + + P + + L N+ VS++++ ++
Sbjct: 1662 GSGEDD-------LVTAPANISNSTWSSALHQTLSNM-------VSQAQSHHEAPKSQED 1707
Query: 585 IVLKALEVKEYEPQEDCSSPAALDSNHNMAPP-----------SDWSPSWVM-------- 625
+ Y PQ+ + P DSN + PP S+ + S M
Sbjct: 1708 TICTMF----YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHI 1763
Query: 626 --------WLELPRCLYNCKD---------IVLRRNTAGSLGFCIVGGYEEYNGNKPFFI 668
W L L N + I L ++ GSLGF + G N ++
Sbjct: 1764 SEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKG----NQRIGCYV 1819
Query: 669 KSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720
+++ PA +DGR++ GD L+ VN + M H LL+ + L I
Sbjct: 1820 HDVIQ-DPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1870
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 20/169 (11%)
Query: 438 RYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPL 497
+ + +S A L ++ ERR H S + +S+G+ S++ PL
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGN--------SSSQVPL 1071
Query: 498 HPTITCHEK------------VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGV 545
H++ +VN++KD LG + GG DL I++ SV PGG
Sbjct: 1072 KENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGP 1131
Query: 546 ISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKE 594
DG +K GD L++V+ V L VS A+ +L+ + L + KE
Sbjct: 1132 ADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKE 1180
Score = 47.8 bits (112), Expect = 4e-05
Identities = 53/243 (21%), Positives = 99/243 (40%), Gaps = 45/243 (18%)
Query: 388 SPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH 447
S + LG + + G ++ +V+ A G+L+ DR++ +N D+ + A +
Sbjct: 1799 SEKGSLGFTVTKGNQRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVN 1857
Query: 448 LIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHP----TITC 503
L++A+ + V LV+ R + E P H T+TC
Sbjct: 1858 LLRAASKTVRLVIGRVL------------------------ELPRIPMLPHLLPDITLTC 1893
Query: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563
++ E LG ++ GG H +Y+ + P V + +G ++ D++ V+G
Sbjct: 1894 NK----------EELGFSLCGG--HDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1941
Query: 564 VELTEVSRSEAVALLKRTSSSIVLKA----LEVKEYEPQEDCSSPAALDSNHNMAPPSDW 619
V ++ E L + S+VLKA L V + S+P + N + + S
Sbjct: 1942 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 2001
Query: 620 SPS 622
P+
Sbjct: 2002 QPA 2004
Score = 47.4 bits (111), Expect = 5e-05
Identities = 27/80 (33%), Positives = 42/80 (52%)
Query: 641 LRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
L+++ LGF I+GG + + FI S+ G PA DG ++ GD L++VN S G+
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 701 IHACLARLLKELKGRITLTI 720
H +L+ +TL I
Sbjct: 1156 SHHAAIEILQNAPEDVTLVI 1175
Score = 47.0 bits (110), Expect = 6e-05
Identities = 54/219 (24%), Positives = 88/219 (40%), Gaps = 42/219 (19%)
Query: 482 SWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE 541
+W+P + N + + E ++ + K SLG TV G + YV V
Sbjct: 1771 NWTPLKNDLENHLEDFELEV---ELLITLIKSEKGSLGFTVTKGNQR----IGCYVHDVI 1823
Query: 542 PGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDC 601
S DGR+K GD L+ V+ ++T ++ ++AV LL+ S ++ L V E
Sbjct: 1824 QDPAKS-DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELP----- 1877
Query: 602 SSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYN 661
+P + DI L N LGF + GG++
Sbjct: 1878 --------------------------RIPMLPHLLPDITLTCNKE-ELGFSLCGGHDSLY 1910
Query: 662 GNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGM 700
+ +I I + A +G ++ D++ VNG ST GM
Sbjct: 1911 --QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGM 1947
Score = 43.5 bits (101), Expect = 7e-04
Identities = 56/218 (25%), Positives = 89/218 (40%), Gaps = 29/218 (13%)
Query: 299 VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE 358
VH +IQ + DGRL PGD ++KVN D++N+ H AV LLR + + L + R
Sbjct: 1819 VHDVIQDPAKS-----DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRV 1873
Query: 359 QKFRSRNNGQAPDAYRPRDDSF-HVI--LNKSSPEEQLGIKLVRKVDE--PGVFIFNVLD 413
+ PR H++ + + +E+LG L D V+I ++
Sbjct: 1874 LEL-------------PRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINP 1920
Query: 414 GGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQ 473
VA G L+ D + +NG + + E + S + L +R P +
Sbjct: 1921 RSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1980
Query: 474 EA-----GWNSNGSWSPGP-GERSNTPKPLHPTITCHE 505
A NGS+S G + + TP T+ E
Sbjct: 1981 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEE 2018
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/70 (34%), Positives = 32/70 (45%), Gaps = 7/70 (10%)
Query: 261 PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLP 320
P L HL+PD +T K E L L GG ++ + I I V A +G L
Sbjct: 1880 PMLPHLLPDITLTCNK-------EELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQL 1932
Query: 321 GDIILKVNGM 330
D+I VNG+
Sbjct: 1933 LDVIHYVNGV 1942
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,942,407
Number of Sequences: 37866
Number of extensions: 1509128
Number of successful extensions: 5402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 315
Number of HSP's successfully gapped in prelim test: 108
Number of HSP's that attempted gapping in prelim test: 4095
Number of HSP's gapped (non-prelim): 1177
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.