Guide to the Human Genome
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Search of human proteins with 186928829

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|186928829 dermokine isoform 4 precursor [Homo sapiens]
         (386 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|186928829 dermokine isoform 4 precursor [Homo sapiens]             806   0.0  
gi|186928827 dermokine isoform 5 precursor [Homo sapiens]             797   0.0  
gi|33504489 dermokine isoform 2 precursor [Homo sapiens]              793   0.0  
gi|186928825 dermokine isoform 3 precursor [Homo sapiens]             790   0.0  
gi|186928831 dermokine isoform 6 [Homo sapiens]                       161   8e-40
gi|57864582 hornerin [Homo sapiens]                                   104   1e-22
gi|55956899 keratin 9 [Homo sapiens]                                  103   3e-22
gi|109255251 loricrin [Homo sapiens]                                  101   1e-21
gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma...    91   1e-18
gi|195972866 keratin 10 [Homo sapiens]                                 91   1e-18
gi|62122917 filaggrin family member 2 [Homo sapiens]                   89   7e-18
gi|119395750 keratin 1 [Homo sapiens]                                  88   1e-17
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      87   2e-17
gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens]           81   2e-15
gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens]          81   2e-15
gi|47132620 keratin 2 [Homo sapiens]                                   81   2e-15
gi|34740329 heterogeneous nuclear ribonucleoprotein A3 [Homo sap...    80   3e-15
gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]    78   1e-14
gi|4504733 insulin receptor substrate 4 [Homo sapiens]                 78   2e-14
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      76   6e-14
gi|14043070 heterogeneous nuclear ribonucleoprotein A1 isoform b...    75   8e-14
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ...    74   2e-13
gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 ...    74   2e-13
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ...    74   2e-13
gi|212549553 interleukin enhancer binding factor 3 isoform d [Ho...    74   3e-13
gi|24234750 interleukin enhancer binding factor 3 isoform a [Hom...    74   3e-13
gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo s...    73   4e-13
gi|48762934 alpha 2 type I collagen [Homo sapiens]                     73   5e-13
gi|239754955 PREDICTED: similar to COL22A1 protein [Homo sapiens]      72   6e-13
gi|60593038 keratin associated protein 5-4 [Homo sapiens]              72   6e-13

>gi|186928829 dermokine isoform 4 precursor [Homo sapiens]
          Length = 386

 Score =  806 bits (2082), Expect = 0.0
 Identities = 386/386 (100%), Positives = 386/386 (100%)

Query: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60
           MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG
Sbjct: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60

Query: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120
           GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV
Sbjct: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120

Query: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180
           IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS
Sbjct: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180

Query: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240
           AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG
Sbjct: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240

Query: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300
           SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS
Sbjct: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300

Query: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTF 360
           GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTF
Sbjct: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTF 360

Query: 361 WKNFKSKLGFINWDAINKDQRSSRIP 386
           WKNFKSKLGFINWDAINKDQRSSRIP
Sbjct: 361 WKNFKSKLGFINWDAINKDQRSSRIP 386


>gi|186928827 dermokine isoform 5 precursor [Homo sapiens]
          Length = 398

 Score =  797 bits (2059), Expect = 0.0
 Identities = 386/398 (96%), Positives = 386/398 (96%), Gaps = 12/398 (3%)

Query: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60
           MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG
Sbjct: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60

Query: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120
           GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV
Sbjct: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120

Query: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180
           IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS
Sbjct: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180

Query: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240
           AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG
Sbjct: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240

Query: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300
           SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS
Sbjct: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300

Query: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ------------NS 348
           GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ            NS
Sbjct: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQGFRGQGVSSNMRNS 360

Query: 349 ETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP 386
           ETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP
Sbjct: 361 ETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP 398


>gi|33504489 dermokine isoform 2 precursor [Homo sapiens]
          Length = 476

 Score =  793 bits (2048), Expect = 0.0
 Identities = 379/380 (99%), Positives = 380/380 (100%)

Query: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60
           MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG
Sbjct: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60

Query: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120
           GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV
Sbjct: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120

Query: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180
           IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS
Sbjct: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180

Query: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240
           AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG
Sbjct: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240

Query: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300
           SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS
Sbjct: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300

Query: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTF 360
           GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTF
Sbjct: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTF 360

Query: 361 WKNFKSKLGFINWDAINKDQ 380
           WKNFKSKLGFINWDAINK+Q
Sbjct: 361 WKNFKSKLGFINWDAINKNQ 380


>gi|186928825 dermokine isoform 3 precursor [Homo sapiens]
          Length = 416

 Score =  790 bits (2041), Expect = 0.0
 Identities = 386/416 (92%), Positives = 386/416 (92%), Gaps = 30/416 (7%)

Query: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60
           MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG
Sbjct: 1   MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAG 60

Query: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120
           GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV
Sbjct: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120

Query: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180
           IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS
Sbjct: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180

Query: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240
           AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG
Sbjct: 181 AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240

Query: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300
           SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS
Sbjct: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS 300

Query: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ-------------- 346
           GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ              
Sbjct: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQGFRGQGVSSNMREI 360

Query: 347 ----------------NSETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP 386
                           NSETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP
Sbjct: 361 SKEGNRLLGGSGDNYRNSETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP 416


>gi|186928831 dermokine isoform 6 [Homo sapiens]
          Length = 189

 Score =  161 bits (408), Expect = 8e-40
 Identities = 73/74 (98%), Positives = 74/74 (100%)

Query: 307 GSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKS 366
           GSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKS
Sbjct: 20  GSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKS 79

Query: 367 KLGFINWDAINKDQ 380
           KLGFINWDAINK+Q
Sbjct: 80  KLGFINWDAINKNQ 93



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 7/59 (11%)

Query: 219 SVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG-------SSGSGSNGDNNNGSSSG 270
           S + + + EG        S G    SGGG+G + G       + GSG +G  N+ +S G
Sbjct: 8   SDQQAKEGEGLEGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 66


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score =  104 bits (260), Expect = 1e-22
 Identities = 103/339 (30%), Positives = 145/339 (42%), Gaps = 42/339 (12%)

Query: 26   SGEESTGTNIGEALGH--GLGDALSEGVGKAIGKEAGGAAGSKVSEAL-GQGTREAVGTG 82
            SG+ S+ +  G   GH  G G   S     + G+  G ++GS       G G+R++ G G
Sbjct: 2114 SGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHG 2173

Query: 83   VRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHN--- 139
             RQ  G G + + G     + H+  +  H  G         G  + RG ++   GH+   
Sbjct: 2174 -RQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGS--------GRSSSRGPYESRSGHSSVF 2224

Query: 140  GAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNG 199
            G  E+  GH    SQ G G       G   +   HG     + +F  + +G+  GQ  + 
Sbjct: 2225 GQHESGSGHSSAYSQHGSGS------GHFCSQGQHGSTSGQSSTF--DQEGSSTGQSSSH 2276

Query: 200  GPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPS------GSGGGSSNSGGGSGSQSG 253
            G    G++   +  Q G GS ++ ++    +    S      GSG G S+S G  GS SG
Sbjct: 2277 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336

Query: 254  -SSGSG--------SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSES 304
             SSG G        S+G   +GS SG SSS    G  SG SS G     G S G S S  
Sbjct: 2337 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE--RHGSSSGSSSSYG 2394

Query: 305  SWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGES 343
              GS +  S G HG  G G+G  P   + G    GSG+S
Sbjct: 2395 QHGSGSRQSLG-HGQHGSGSGQSPSPSR-GRHGSGSGQS 2431



 Score =  103 bits (256), Expect = 3e-22
 Identities = 111/346 (32%), Positives = 148/346 (42%), Gaps = 25/346 (7%)

Query: 26   SGEESTGTNIGEALGH--GLGDALSEGVGKAIGKEAGGAAGSKVSEAL-GQGTREAVGTG 82
            SG+ S+ +  G   GH  G G   S     + G+  G ++GS       G G+R++ G G
Sbjct: 1174 SGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHG 1233

Query: 83   VRQVPGFGAADALGNRVGEAAHAL--GNTGHEIGRQAED---VIRHGADAVRGSWQGVPG 137
             RQ  G G + + G       H+   G  G   GR +       R G  +V G  +   G
Sbjct: 1234 -RQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSG 1292

Query: 138  HNGAWETSG-GHGIFGSQGGLG---GQG-----QGNPGGLGTPWVHGYPGNSAGSFGMNP 188
            H+ A+   G G G F SQG  G   GQ      +G+  G  + + H   G+S  S G   
Sbjct: 1293 HSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSS-GYGR 1351

Query: 189  QGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE-GCTNPPPSGSGGGSSNSGGG 247
             GA  GQ  + G    G+    +  Q G GS  +S+    G  +   SG G   S+S   
Sbjct: 1352 HGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQS 1411

Query: 248  SGSQSGSSGSG-SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGG--SRGDSGSES 304
            SG     SGSG S+    +GS SG SS G   G SSG SS      SG   S G     S
Sbjct: 1412 SGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGS 1471

Query: 305  SWGSSTGSSSGNHG-GSGGGNGHKP-GCEKPGNEARGSGESGIQNS 348
              G S   S G HG GSG  + + P G     + +RG  ESG  +S
Sbjct: 1472 GSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHS 1517



 Score =  102 bits (255), Expect = 4e-22
 Identities = 106/354 (29%), Positives = 148/354 (41%), Gaps = 49/354 (13%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAG------SKVSEA 70
            G GE+      E S+G +   +  HG G   S G G+   +    + G      S+ S  
Sbjct: 1630 GLGESSGFGHHESSSGQSSSYSQ-HGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSR 1688

Query: 71   LGQ---GTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADA 127
             GQ   G+R++ G G RQ  G G + + G       H+  +  H  G         G  +
Sbjct: 1689 YGQHGSGSRQSSGHG-RQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGS--------GRSS 1739

Query: 128  VRGSWQGVPGHN---GAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSF 184
             RG ++   GH+   G  E+  GH    SQ G G       G   +   HG     + +F
Sbjct: 1740 SRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGS------GHFCSQGQHGSTSGQSSTF 1793

Query: 185  GMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPS------GSG 238
              + +G+  GQ  + G    G++   +  Q G GS ++ ++    +    S      GSG
Sbjct: 1794 --DQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSG 1851

Query: 239  GGSSNSGGGSGSQSG-SSGSG--------SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGS 289
             G S+S G  GS SG SSG G        S+G   +GS SG SSS    G  SG SS G 
Sbjct: 1852 SGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE 1911

Query: 290  SGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGES 343
                G S G S S    GS +  S G HG  G G+G  P   + G    GSG+S
Sbjct: 1912 --QHGSSSGSSSSYGQHGSGSRQSLG-HGQHGSGSGQSPSPSR-GRHGSGSGQS 1961



 Score =  100 bits (249), Expect = 2e-21
 Identities = 107/357 (29%), Positives = 146/357 (40%), Gaps = 40/357 (11%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG-------KAIGKEAGGAAGSKVS 68
            GSG       G+  +G+    + G HG G   S G G       ++ G    G+     S
Sbjct: 2306 GSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSS 2365

Query: 69   EALGQGTREAVGT-GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR---QAEDVIRHG 124
                 G+R    + G R     G++ + G     +  +LG+  H  G     +    RHG
Sbjct: 2366 SYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHG 2425

Query: 125  ADAVRGSWQGVPGHNGAWETSGGHGIFGS--QGGLG------GQGQG---NPGGLGTPWV 173
            + + + S     G    W +S G    GS    GLG      GQ  G   +    G    
Sbjct: 2426 SGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSST 2485

Query: 174  HGYPGNSAG-SFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNP 232
            HG  G+++G S      GA  GQ  + G    G++      + G GS ++    +  +  
Sbjct: 2486 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGS 2545

Query: 233  PPSGSGGGSSNSGGGSGSQSGSSGSG---SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGS 289
              S S G    SG G  S SG  GSG   S+G  ++ SSSG SSS S  G  SG SSG  
Sbjct: 2546 RQSPSYG-RHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG-- 2602

Query: 290  SGNSGGSRGDSGSESSWGSSTGSSS--GNHG-GSGGGNGHKPGCEKPGNEARGSGES 343
             G  G   G S      GSS+GSSS  G HG GS   +GH       G +  GSG+S
Sbjct: 2603 YGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGH-------GRQGSGSGQS 2652



 Score = 98.6 bits (244), Expect = 8e-21
 Identities = 103/370 (27%), Positives = 140/370 (37%), Gaps = 53/370 (14%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG-------KAIGKEAGGAAGSKVS 68
            GSG       G+  +G+    + G HG G   S G G       ++ G    G+     S
Sbjct: 1836 GSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSS 1895

Query: 69   EALGQGTREAVGT-GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR---QAEDVIRHG 124
                 G+R    + G +     G++ + G     +  +LG+  H  G     +    RHG
Sbjct: 1896 SYEQHGSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHG 1955

Query: 125  ADAVRGSWQGVPGHNGAWETSGGHGIFGS--QGGLG------------GQGQGNPGGLGT 170
            + + + S  G  G    W +S G    GS    GLG            GQ   + G   T
Sbjct: 1956 SGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSST 2015

Query: 171  PWVHGYPGNSAGSFGMNP----QGAPWGQGGNGGPPNFGTNTQGAVA--QPGYGSVRASN 224
               HG     + S G +     Q +  GQ G+G   + G   QG+ +   PG+G   + +
Sbjct: 2016 HGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGS 2075

Query: 225  QNEGCTNPPPSGSGGGSSNSGGGSG-----------SQSGSSGSGSNGDNNNGSSSGGSS 273
            +         SGSG  SS+   G G           S SG S S S   + +G SSG   
Sbjct: 2076 RQSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQ 2135

Query: 274  SGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKP 333
             GS SG SS G   GSS  S    G  GS S         S  HG  G G+GH P     
Sbjct: 2136 HGSRSGQSSRGERHGSSSGSSSRYGQHGSGS-------RQSSGHGRQGSGSGHSP---SR 2185

Query: 334  GNEARGSGES 343
            G    GSG S
Sbjct: 2186 GRHGSGSGHS 2195



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 101/373 (27%), Positives = 143/373 (38%), Gaps = 35/373 (9%)

Query: 19   GEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREA 78
            G      SG    G+  G++ GHG   + S     + G+   G+  S  S   G G  E+
Sbjct: 1576 GSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQ-SPSYGRHGSGSGRSSSSGQHGSGLGES 1634

Query: 79   VGTGVRQVPGFGAADALGNRVGEAAHALGNTGH-EIGRQAEDVIRHGADAVRGSWQGVPG 137
             G G  +    G + +       + H+ G   H     Q+    RHG+ +   S  G   
Sbjct: 1635 SGFGHHESSS-GQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQ-- 1691

Query: 138  HNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG-SFGMNPQGAPWGQG 196
            H      S GHG  GS  G       +  GLG    HG  G+ +G S    P  +  G  
Sbjct: 1692 HGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHS 1751

Query: 197  GNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSG 256
               G    G+    A +Q G GS    +Q +        GS  G S++    GS +G S 
Sbjct: 1752 SVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ-------HGSTSGQSSTFDQEGSSTGQSS 1804

Query: 257  S-GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG---- 311
            S G +G  ++ SSS G     S    S G  G  SG+S  S G  GS S W SS+G    
Sbjct: 1805 SHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSS-SYGQHGSGSGWSSSSGRHGS 1863

Query: 312  -----SSSGNHGGS----------GGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFN 356
                 S  G+H  S          G G+GH    E+ G+ + G    G Q+  +S    +
Sbjct: 1864 GSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRS-GQSSRGEQHGSSSGSSSS 1922

Query: 357  FDTFWKNFKSKLG 369
            +       +  LG
Sbjct: 1923 YGQHGSGSRQSLG 1935



 Score = 95.9 bits (237), Expect = 5e-20
 Identities = 92/333 (27%), Positives = 127/333 (38%), Gaps = 22/333 (6%)

Query: 19   GEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREA 78
            G      SG    G+  G++ GHG   + S     + G+   G+  S  S   G G  E+
Sbjct: 1106 GSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQ-SPSYGRHGSGSGRSSSSGQHGSGLGES 1164

Query: 79   VGTGVRQVPGFGAADALGNRVGEAAHALGNTGH-EIGRQAEDVIRHGADAVRGSWQGVPG 137
             G G  +    G + +       + H+ G   H     Q+    RHG+ +   S  G   
Sbjct: 1165 SGFGHHESSS-GQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQ-- 1221

Query: 138  HNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG-SFGMNPQGAPWGQG 196
            H      S GHG  GS  G       +  GLG    HG  G+ +G S    P  +  G  
Sbjct: 1222 HGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHS 1281

Query: 197  GNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSG 256
               G    G+    A +Q G GS    +Q +        GS  G S++    GS +G S 
Sbjct: 1282 SVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ-------HGSTSGQSSTFDQEGSSTGQSS 1334

Query: 257  SGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGN 316
            S  +  + +  SSG    G+ SG S      GS      S G  GS S W SS+G     
Sbjct: 1335 SYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSG 1394

Query: 317  HGGSGGGNGHK------PGCEKPGNEARGSGES 343
             G S G   H+       GC + G+   GSG S
Sbjct: 1395 SGQSSGFGHHESSSWQSSGCTQHGS---GSGHS 1424



 Score = 95.5 bits (236), Expect = 7e-20
 Identities = 106/376 (28%), Positives = 143/376 (38%), Gaps = 52/376 (13%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG-------KAIGKEAGGAAGSKVS 68
            GSG       G+  +G+    + G HG G   S G G       ++ G    G+     S
Sbjct: 1366 GSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSS 1425

Query: 69   EALGQGTREAVGT-GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR---QAEDVIRHG 124
                 G+R    + G R     G++ + G     +  +LG+  H  G     +    RHG
Sbjct: 1426 SYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHG 1485

Query: 125  ADAVRGSWQGVPGHNGAWETSGGHGIFGSQ--GGLG------------GQGQGNPGGLGT 170
            + + + S     G    W +S G    GS    GLG            GQ   + G   T
Sbjct: 1486 SGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSST 1545

Query: 171  PWVHGYPGNSAGSFGMNP----QGAPWGQGGNGGPPNFGTNTQGAVA--QPGYGSVRASN 224
               HG     + S G +     Q +  GQ G+G   + G   QG+ +   PG+G   + +
Sbjct: 1546 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGS 1605

Query: 225  QNEGCTNPPPSGSGGGSSNSGGGSG-----------SQSGSSGSGSNGDNNNGSSSGGSS 273
            +         SGSG  SS+   GSG           S SG S S S   + +G SSG   
Sbjct: 1606 RQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQ 1665

Query: 274  SGSSSGGSSGGSSGGSSGNSGGSRGDSGS---ESSWGSSTGSSSG---NHGGSGGGNGHK 327
             GS SG SS G   GSS  S    G  GS   +SS     GS SG   + G  G G GH 
Sbjct: 1666 HGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHS 1725

Query: 328  PGCEKPGNEARGSGES 343
                  G    GSG S
Sbjct: 1726 ---SSHGQHGSGSGRS 1738



 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 100/341 (29%), Positives = 146/341 (42%), Gaps = 46/341 (13%)

Query: 26   SGEEST----GTNIGEALGHGL-GDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVG 80
            SG+ S+    G + G++  HG  G   S+  G   G++  G+  S      G G+R++  
Sbjct: 2493 SGQSSSCGQHGASSGQSSSHGQHGSGSSQSSG--YGRQGSGSGQSPGHGQRGSGSRQSPS 2550

Query: 81   TGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR-QAEDVIRHGADAVRGSWQGVPGHN 139
             G R   G G + + G        + G   HE    Q+    +HG+ +         GH 
Sbjct: 2551 YG-RHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGS---------GH- 2599

Query: 140  GAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGN-SAGSFGMNPQGAPWGQGGN 198
                 S G+G  GS+ G   +G+ +    G+   +G  G+ S  S G   QG+  GQ  +
Sbjct: 2600 -----SSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPS 2654

Query: 199  GGPPNFGTNTQGAVAQPGYGSVRASNQ--------NEGCTNPPPSGSGGGSSNSGGGSGS 250
             G    G     +  Q G GS R+S++        +        SGSG  S+ S  GSGS
Sbjct: 2655 RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSGS 2714

Query: 251  -------QSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSE 303
                   Q GS+   S+  +  GSS+G SSS    G  S  SSG   G  G   G S S 
Sbjct: 2715 GHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSG--YGRHGAGSGQSLSH 2772

Query: 304  SSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESG 344
               GS +G SS ++G  G G+G   G  + G+   GSG+ G
Sbjct: 2773 GRHGSGSGQSS-SYGQHGSGSGQSSGYSQHGS---GSGQDG 2809



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 103/374 (27%), Positives = 141/374 (37%), Gaps = 49/374 (13%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG--KAIGKEAG----GAAGSKVSE 69
            GSG       G   +G+    + G HG G   S G G   + G+ +G    G+     S 
Sbjct: 897  GSGSGQSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSS 956

Query: 70   ALGQGTREAVGTGVRQV-PGFGAADALGNRVGEAAHALGNTGHEIGR---QAEDVIRHGA 125
                G+R    +   Q     G++ + G     +  +LG+  H  G     +    RHG+
Sbjct: 957  YEQHGSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGS 1016

Query: 126  DAVRGSWQGVPGHNGAWETSGGHGIFGS--QGGLG------------GQGQGNPGGLGTP 171
             + + S  G       W +S G    GS    GLG            GQ   + G   T 
Sbjct: 1017 GSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTH 1076

Query: 172  WVHGYPGNSAGSFGMNP----QGAPWGQGGNGGPPNFGTNTQGAVA--QPGYGSVRASNQ 225
              HG     + S G +     Q +  GQ G+G   + G   QG+ +   PG+G   + ++
Sbjct: 1077 GQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSR 1136

Query: 226  NEGCTNPPPSGSGGGSSNSGGGSG-----------SQSGSSGSGSNGDNNNGSSSGGSSS 274
                     SGSG  SS+   GSG           S SG S S S   + +G SSG    
Sbjct: 1137 QSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQH 1196

Query: 275  GSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPG 334
            GS SG SS G   GSS  S    G  GS S         S  HG  G G+GH P   + G
Sbjct: 1197 GSRSGQSSRGERHGSSSGSSSHYGQHGSGS-------RQSSGHGRQGSGSGHSPSRGRHG 1249

Query: 335  NEARGSGESGIQNS 348
            +    S   G   S
Sbjct: 1250 SGLGHSSSHGQHGS 1263



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 97/339 (28%), Positives = 133/339 (39%), Gaps = 17/339 (5%)

Query: 19   GEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREA 78
            G      SG    G+  G++ GHG   + S     + G+   G+  S  S   G G  E+
Sbjct: 2046 GSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQ-SPSYGRHGSGSGRSSSSGQHGPGLGES 2104

Query: 79   VGTGVRQVPGFGAADALGNRVGEAAHALGNTGH-EIGRQAEDVIRHGADAVRGSWQGVPG 137
             G G  +    G + +       + H+ G   H     Q+    RHG+ +   S  G   
Sbjct: 2105 SGFGHHESSS-GQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQ-- 2161

Query: 138  HNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG-SFGMNPQGAPWGQG 196
            H      S GHG  GS  G       +  G G    HG  G+ +G S    P  +  G  
Sbjct: 2162 HGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGHS 2221

Query: 197  GNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSG 256
               G    G+    A +Q G GS    +Q +        GS  G S++    GS +G S 
Sbjct: 2222 SVFGQHESGSGHSSAYSQHGSGSGHFCSQGQ-------HGSTSGQSSTFDQEGSSTGQSS 2274

Query: 257  S-GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG-SSS 314
            S G +G  ++ SSS G     S    S G  G  SG+S  S G  GS S W SS+G   S
Sbjct: 2275 SHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSS-SYGQHGSGSGWSSSSGRHGS 2333

Query: 315  GNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
            G+   SG G+      +  G    GSG SG  +S    G
Sbjct: 2334 GSGQSSGFGHHESSSWQSSGYTQHGSG-SGHSSSYEQHG 2371



 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 98/344 (28%), Positives = 136/344 (39%), Gaps = 35/344 (10%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALGHGL-GDALSEGVGKAIGKEAGGAAGSKVSEALGQGT 75
            GS        G+  +G+   ++LGHG  G    +    + G+   G+  S      G G+
Sbjct: 1914 GSSSGSSSSYGQHGSGSR--QSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGS 1971

Query: 76   REAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGV 135
              +   G  +  G G +  LG+R   +  + G   H  G  +     HG           
Sbjct: 1972 GWSSSRGPYE-SGSGHSSGLGHRESRSGQSSGYGQH--GSSSGHSSTHGQHGSASGQSSS 2028

Query: 136  PGHNGAWE-TSGGHGIFGS----QGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQG 190
             G +GA    S  HG  GS      G G QG G+    G    HG  G+ +       Q 
Sbjct: 2029 CGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPG----HGQRGSGSR------QS 2078

Query: 191  APWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPS----GSGGGSSNSGG 246
              +G+ G+G   +  +   G    PG G       +E  +    S    GSG G S+  G
Sbjct: 2079 PSYGRHGSGSGRSSSSGQHG----PGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYG 2134

Query: 247  GSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSW 306
              GS+SG S  G    +++GSSS     GS S  SSG    GS      SRG  GS    
Sbjct: 2135 QHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGS---- 2190

Query: 307  GSSTGSSSGNHG-GSGGGNGHKPGCEKPGNEA-RGSGESGIQNS 348
            GS   SS G HG GSG  +   P   + G+ +  G  ESG  +S
Sbjct: 2191 GSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS 2234



 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 108/355 (30%), Positives = 144/355 (40%), Gaps = 31/355 (8%)

Query: 17  GSGEA-GPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGG----AAGSKVSEAL 71
           GSG + G  Q G  S  ++ GE  G   G + S G   +  +++ G     +GS  S + 
Sbjct: 484 GSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSP 543

Query: 72  GQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGS 131
            +G  E+   G RQ   +G       R          +GH  G   ++  R G  +  G 
Sbjct: 544 SRGRHES---GSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQES-RSGQSSGYGQ 599

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGA 191
                GH+    T G HG    Q    GQ     G   +   HG   + +  +G   QG+
Sbjct: 600 HGSSSGHSS---THGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQ--QGS 654

Query: 192 PWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG-S 250
             GQ  + G          +  Q G GS  +S+     +    S   G  S SG  SG S
Sbjct: 655 GSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYS 714

Query: 251 QSGSSGSGSNGDNNNGSSSG--------GSSSG-SSSGGSSGGSSGGSSGN--SGGSRGD 299
           Q GS  S S+G   +GS SG        GSSSG SSS G  G  S  SSG+   G   G 
Sbjct: 715 QHGSGSSHSSGYRKHGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGH 774

Query: 300 SGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGE-SGIQNSETSPG 353
           S S    GSS+G SS +HG  G G      C   G+   GSG+ SG    E+  G
Sbjct: 775 SPSRVRHGSSSGHSS-SHGQHGSGTSCSSSC---GHYESGSGQASGFGQHESGSG 825



 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 106/385 (27%), Positives = 148/385 (38%), Gaps = 57/385 (14%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG---------KAIGKEAGGAAGSK 66
            GSG       G   +G     + G HG G   S   G            G+   G+  S 
Sbjct: 1706 GSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSS 1765

Query: 67   VSEALGQGTREAVGTGVRQVPGFGAA--DALGNRVGEAA----HALGNT-GHEIGRQAED 119
                 G G+      G        ++  D  G+  G+++    H  G++     G+Q   
Sbjct: 1766 AYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSG 1825

Query: 120  VIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLG----TPWVH- 174
                G    RG      GH+ ++   G    + S  G  G G G   G G    + W   
Sbjct: 1826 ---SGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSS 1882

Query: 175  GYPGNSAGS---FGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCT- 230
            GY  + +GS         G+  GQ   G      + +  +  Q G GS ++    +  + 
Sbjct: 1883 GYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSG 1942

Query: 231  ---NPPPS----GSGGGSSNSGGGSGSQSG--------SSGSGSNG-----DNNNGSSSG 270
               +P PS    GSG G S+S G  GS SG         SGSG +      ++ +G SSG
Sbjct: 1943 SGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSG 2002

Query: 271  GSSSGSSSGGSS-----GGSSGGSS--GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGG 323
                GSSSG SS     G +SG SS  G  G S G S S    GS +  SSG +G  G G
Sbjct: 2003 YGQHGSSSGHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSG-YGRQGSG 2061

Query: 324  NGHKPGCEKPGNEARGSGESGIQNS 348
            +G  PG  + G+ +R S   G   S
Sbjct: 2062 SGQSPGHGQRGSGSRQSPSYGRHGS 2086



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 103/379 (27%), Positives = 147/379 (38%), Gaps = 74/379 (19%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGK---------AIGKEAGGAAGSK 66
           GSG       G+  + +    + G HG     S   G+           G+ + G+  S 
Sbjct: 365 GSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSP 424

Query: 67  VSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQ-AEDVIRHGA 125
                G G+ ++  +G +   GFG + + G  V  + ++ G   HE   + +    +HG+
Sbjct: 425 GHGQRGSGSGQSPSSG-QHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGS 483

Query: 126 DAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGN-SAGSF 184
            +         GH      S GHG  GS+ G   +G+      G+   +G  G+ S  S 
Sbjct: 484 GS---------GH------SSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSL 528

Query: 185 GMNPQGAPWGQGGNG--GPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGS- 241
           G +  G+  GQ  +   G    G+    +    GYGS R+S++      P  SGSG  S 
Sbjct: 529 GHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRG-----PYESGSGHSSG 583

Query: 242 -----SNSGGGSG-SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGG 295
                S SG  SG  Q GSS   S+    +GS+SG SSS    G +SG SS      SG 
Sbjct: 584 LGHQESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGS 643

Query: 296 SR------------------------------GDSGSESSWGSSTGSSSGNHGGSGGGNG 325
           S+                              G  GS S W SS G   G+  G   G G
Sbjct: 644 SQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNG-PHGSVSGQSSGFG 702

Query: 326 HKPGC-EKPGNEARGSGES 343
           HK G  +  G    GSG S
Sbjct: 703 HKSGSGQSSGYSQHGSGSS 721



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 107/384 (27%), Positives = 149/384 (38%), Gaps = 55/384 (14%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG---------KAIGKEAGGAAGSK 66
            GSG       G   +G     + G HG G   S   G            G+   G+  S 
Sbjct: 1236 GSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSS 1295

Query: 67   VSEALGQGTREAVGTGVRQVPGFGAA--DALGNRVGEAAHALGNTGHEIGRQAEDVIRHG 124
                 G G+      G        ++  D  G+  G+++ + G+ G     Q+    RHG
Sbjct: 1296 AYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSS-SYGHRGSG-SSQSSGYGRHG 1353

Query: 125  ADA----VRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLG----TPWVHG- 175
            A +     RG      GH+ ++   G    + S  G  G G G   G G    + W    
Sbjct: 1354 AGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSG 1413

Query: 176  ---YPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCT-- 230
               +   S  S      G+  GQ   G      + +  +  Q G GS ++    +  +  
Sbjct: 1414 CTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGS 1473

Query: 231  --NPPPS----GSGGGSSNS----GGGSG-------SQSGSSGSGSNG--DNNNGSSSGG 271
              +P PS    GSG G S+S    G GSG        +SGSS S   G  ++ +G SSG 
Sbjct: 1474 GQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGY 1533

Query: 272  SSSGSSSGGSS-----GGSSGGSS--GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGN 324
               GSSSG SS     G +SG SS  G  G S G S S    GS +  SSG +G  G G+
Sbjct: 1534 GQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSG-YGRQGSGS 1592

Query: 325  GHKPGCEKPGNEARGSGESGIQNS 348
            G  PG  + G+ +R S   G   S
Sbjct: 1593 GQSPGHGQRGSGSRQSPSYGRHGS 1616



 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 104/378 (27%), Positives = 142/378 (37%), Gaps = 59/378 (15%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALGH---GLGDALSEGV---GKAIG-KEAGGAAGSKVSE 69
            GS        G+  +GT+   + GH   G G A   G    G   G  + G A+G   S+
Sbjct: 782  GSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQ 841

Query: 70   ALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR-------------- 115
                 T     +  +     G + + G     + HA G   H  G               
Sbjct: 842  GRHGSTSGQSSSSGQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSG 901

Query: 116  QAEDVIRHGADAVRGSWQGVPGHNGAWETSGGH-GIFGSQGGLGGQGQGN---------- 164
            Q+    RHG+ + R S  G  G      +  GH    G   G    G G+          
Sbjct: 902  QSPSYGRHGSGSGRSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHG 961

Query: 165  --PGGLGTPWVHGYPGNSAGSFGMNPQGAPW----GQGGNGG----PPNFGTNTQGAVAQ 214
               G       HG    S+ S+G +  G+      GQ G+G      P+ G +  G+   
Sbjct: 962  SRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQS 1021

Query: 215  PGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSS 274
              YG  R+ +       P  SGSG  S     G G +   SG  S+G   +GSSSG SS+
Sbjct: 1022 SSYGPYRSGSGWSSSRGPYESGSGHSS-----GLGHRESRSGQ-SSGYGQHGSSSGHSST 1075

Query: 275  ----GSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGC 330
                GS+SG SS      S G  G S G S S    GS +  SSG +G  G G+G  PG 
Sbjct: 1076 HGQHGSTSGQSS------SCGQHGASSGQSSSHGQHGSGSSQSSG-YGRQGSGSGQSPGH 1128

Query: 331  EKPGNEARGSGESGIQNS 348
             + G+ +R S   G   S
Sbjct: 1129 GQRGSGSRQSPSYGRHGS 1146



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 105/385 (27%), Positives = 148/385 (38%), Gaps = 57/385 (14%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVG---------KAIGKEAGGAAGSK 66
            GSG       G   +G+    + G HG G   S   G            G+   G+  S 
Sbjct: 2176 GSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSS 2235

Query: 67   VSEALGQGTREAVGTGVRQVPGFGAA--DALGNRVGEAA----HALGNT-GHEIGRQAED 119
                 G G+      G        ++  D  G+  G+++    H  G++     G+Q   
Sbjct: 2236 AYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSG 2295

Query: 120  VIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLG----TPWVH- 174
                G    RG      GH+ ++   G    + S  G  G G G   G G    + W   
Sbjct: 2296 ---SGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSS 2352

Query: 175  GYPGNSAGS---FGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCT- 230
            GY  + +GS         G+  GQ   G      + +  +  Q G GS ++    +  + 
Sbjct: 2353 GYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSG 2412

Query: 231  ---NPPPS----GSGGGSSNS----GGGSG---------SQSGSSGSGSNGDNNNGSSSG 270
               +P PS    GSG G S+S    G GSG         S SG S    + ++ +G SSG
Sbjct: 2413 SGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSG 2472

Query: 271  GSSSGSSSGGSS-----GGSSGGSS--GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGG 323
                GSSSG SS     G +SG SS  G  G S G S S    GS +  SSG +G  G G
Sbjct: 2473 YGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSG-YGRQGSG 2531

Query: 324  NGHKPGCEKPGNEARGSGESGIQNS 348
            +G  PG  + G+ +R S   G   S
Sbjct: 2532 SGQSPGHGQRGSGSRQSPSYGRHGS 2556



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 106/377 (28%), Positives = 155/377 (41%), Gaps = 58/377 (15%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGK---AIGKEAGGA---AGSKVSE 69
           GSG       G+  +G+    +   HG G   S G  +   + G+ +G +   +GS  S 
Sbjct: 196 GSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSS 255

Query: 70  ALGQ-GTREAVGT-GVRQVPGFGAADALGNRVGEAAHALGNTGHEIG-RQAEDVIRHGAD 126
             GQ G+R    + G R     G++ + G     +  +LG+     G RQ+   +RHG+ 
Sbjct: 256 GYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSG 315

Query: 127 AVRGSWQGVPGHNGAWETSGGHGIFGS---------QGGLG--------GQGQGNPGGLG 169
           +   S  G  G   ++  S GH   GS         + G G        G G G+    G
Sbjct: 316 SGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQG 375

Query: 170 TPWVHGYPGNSAGSFGMNP----QGAPWGQGGNGGPPNFGT--NTQGAVAQPGYGSVRAS 223
               HG     A S G +     Q + +GQ  +    + G   ++ G+   PG+G     
Sbjct: 376 Q---HGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQ---- 428

Query: 224 NQNEGCTNPPPSGSGG---GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG 280
            +  G    P SG  G   G S+S G   S SG S    + ++++  SSG +  GS SG 
Sbjct: 429 -RGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGH 487

Query: 281 SSG-GSSGGSSGNS------GGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKP 333
           SSG G  G  SG S      G S G S S    GS +  S G H   G G+G  P     
Sbjct: 488 SSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLG-HSRHGSGSGQSP----- 541

Query: 334 GNEARGSGESGIQNSET 350
            + +RG  ESG + S +
Sbjct: 542 -SPSRGRHESGSRQSSS 557



 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 106/375 (28%), Positives = 141/375 (37%), Gaps = 61/375 (16%)

Query: 26   SGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQ 85
            SG  S+    G   G   G     G G++ G    G+  S  S     G+R    +   Q
Sbjct: 682  SGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQ 741

Query: 86   VPGFGAADALGNRVGEAAHALGN---TGHEIGRQAEDV------IRHGADAVRGSWQGVP 136
                G++  L +  G+  H  G+   +GH  GRQ          +RHG+ +   S  G  
Sbjct: 742  ---HGSSSGLSSSYGQ--HGSGSHQSSGH--GRQGSGSGHSPSRVRHGSSSGHSSSHGQH 794

Query: 137  GHNGAWETSGGHGIFGSQGGLG------GQGQGNP------GGLGTPWVHGYPGNSAGSF 184
            G   +  +S GH   GS    G      G GQG        G   +   HG     + S 
Sbjct: 795  GSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSS 854

Query: 185  GMNP----QGAPWGQ---------------GGNGGPPNFGTNTQGAVAQPGYGSVRASNQ 225
            G +     Q + +GQ                G+G  P  G    G+   P YG   + + 
Sbjct: 855  GQHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSG 914

Query: 226  NEGCTNPPPSGSG-----GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG 280
                +    SGSG     G  S+SG  SG     SGSG +       S  G SS S   G
Sbjct: 915  RSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHG 974

Query: 281  SSGGSSGGSSGNSGGSR-----GDSGSESSWGSSTGSSSGNHG-GSGGGNGHKPGCEKPG 334
            SS GSS     +  GSR     G  GS S  G S   S G HG GSG  + + P     G
Sbjct: 975  SSSGSSSSYGQHGSGSRQSLGHGQHGSGS--GQSPSPSRGRHGSGSGQSSSYGPYRSGSG 1032

Query: 335  -NEARGSGESGIQNS 348
             + +RG  ESG  +S
Sbjct: 1033 WSSSRGPYESGSGHS 1047



 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 93/314 (29%), Positives = 123/314 (39%), Gaps = 14/314 (4%)

Query: 19   GEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREA 78
            G      SG    G+  G++ GHG   + S     + G+   G+  S  S   G G  E+
Sbjct: 2516 GSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQ-SPSYGRHGSGSGRSSSSGQHGSGLGES 2574

Query: 79   VGTGVRQVPGFGAADALGNRVGEAAHALGNTGH-EIGRQAEDVIRHGADAVRGSWQGVPG 137
             G G  +    G + +       + H+ G   H     Q+    RHG+ +   S  G   
Sbjct: 2575 SGFGHHESSS-GQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQ-- 2631

Query: 138  HNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG-SFGMNPQGAPWGQG 196
            H      S GHG  GS  G       +  GLG    HG  G+ +G S    P  +  G  
Sbjct: 2632 HGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHS 2691

Query: 197  GNGGPPNFGTNTQGAVAQPGYGSVRASNQNE-GCTNPPPS-----GSGGGSSNSGGGSGS 250
               G    G+    A +Q G GS    +Q + G T+   S     GS  G S+S G  GS
Sbjct: 2692 SVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGS 2751

Query: 251  QSG-SSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGG-SRGDSGSESSWGS 308
             S  SSG G +G  +  S S G     S   SS G  G  SG S G S+  SGS     S
Sbjct: 2752 GSSQSSGYGRHGAGSGQSLSHGRHGSGSGQSSSYGQHGSGSGQSSGYSQHGSGSGQDGYS 2811

Query: 309  STGSSSGNHGGSGG 322
                 S + GGS G
Sbjct: 2812 YCKGGSNHDGGSSG 2825



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 91/346 (26%), Positives = 134/346 (38%), Gaps = 35/346 (10%)

Query: 26   SGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQ 85
            SG    G+  G++ GHG   + S G   + G+   G+  S  S   G G+ ++       
Sbjct: 878  SGRGRHGSGSGQSPGHGQRGSGS-GQSPSYGRHGSGSGRSSSSGRHGSGSGQS------- 929

Query: 86   VPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETS 145
              GFG   + G   G   H  G+ GH    +     +HG+ + + S     G +    +S
Sbjct: 930  -SGFGHKSSSGQSSGYTQHGSGS-GHSSSYE-----QHGSRSGQSSRSEQHGSSSGSSSS 982

Query: 146  GGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG---SFGMNPQGAPWG------QG 196
             G    GS+  LG    G+  G       G  G+ +G   S+G    G+ W       + 
Sbjct: 983  YGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYES 1042

Query: 197  GNGGPPNFGTNTQGAVAQPGYGSVRASNQNE------GCTNPPPSGSGGGSSNSGGGSG- 249
            G+G     G     +    GYG   +S+ +       G T+   S  G   ++SG  S  
Sbjct: 1043 GSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSH 1102

Query: 250  SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSS 309
             Q GS  S S+G    GS SG S      G  SG     S G  G   G S S    GS 
Sbjct: 1103 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRG--SGSRQSPSYGRHGSGSGRSSSSGQHGSG 1160

Query: 310  TGSSS--GNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
             G SS  G+H  S G +            + G G+ G ++ ++S G
Sbjct: 1161 LGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRG 1206



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 95/342 (27%), Positives = 135/342 (39%), Gaps = 31/342 (9%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALGHGL-GDALSEGVGKAIGKEAGGAAGSKVSEALGQGT 75
            GS        G+  +G+   ++LGHG  G    +    + G+   G+  S        G+
Sbjct: 974  GSSSGSSSSYGQHGSGSR--QSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGS 1031

Query: 76   REAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGV 135
              +   G  +  G G +  LG+R   +  + G   H  G  +     HG           
Sbjct: 1032 GWSSSRGPYE-SGSGHSSGLGHRESRSGQSSGYGQH--GSSSGHSSTHGQHGSTSGQSSS 1088

Query: 136  PGHNGAWE-TSGGHGIFGS----QGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQG 190
             G +GA    S  HG  GS      G G QG G+    G    HG  G+ +       Q 
Sbjct: 1089 CGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPG----HGQRGSGSR------QS 1138

Query: 191  APWGQGGNGG--PPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGS 248
              +G+ G+G     + G +  G     G+G   +S+      +    GSG G S+  G  
Sbjct: 1139 PSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQ--HGSGSGHSSGYGQH 1196

Query: 249  GSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGS 308
            GS+SG S  G    +++GSSS     GS S  SSG    GS      SRG  GS    G 
Sbjct: 1197 GSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGS----GL 1252

Query: 309  STGSSSGNHG-GSGGGNGHKPGCEKPGNEA-RGSGESGIQNS 348
               SS G HG GSG  +   P   + G+ +  G  ESG  +S
Sbjct: 1253 GHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS 1294



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 105/400 (26%), Positives = 162/400 (40%), Gaps = 80/400 (20%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGK--------AIGKEAGGAAGSKVS 68
           GSG++      + S+G + G +  HG G   S G G+        + G+    ++GS  S
Sbjct: 224 GSGQSSGFSQHKSSSGQSSGYSQ-HGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSS 282

Query: 69  EAL-GQGTREAVGTG------------VRQVPGFGAADALGNRVGEAAHALGNTGHEIGR 115
               G G+R+++G G            VR   G G + + G     ++++     +E G 
Sbjct: 283 YGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGS 342

Query: 116 --------------QAEDVIRHGADAVRGSWQGVPGH-NGAWETSGGHGIFGSQGGLGGQ 160
                         Q+    +HG+ +   S QG  G  +G   +SG HG    Q    GQ
Sbjct: 343 GQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQ 402

Query: 161 ---------GQG-NPGGLGTPWVHGYPGNSAGSFGMNPQ-GAPWGQGGNGGPPNFGTNTQ 209
                    G+G +  G G    HG  G+ +G    + Q G  +G+  + GP        
Sbjct: 403 HESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSSGP-----YVS 457

Query: 210 GAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSS 269
           G+    G+G   +S+++   +     GSG G S+  G  GS+SG S  G    ++ GSSS
Sbjct: 458 GSGYSSGFGHHESSSEHS--SGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSS 515

Query: 270 G----GSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESS-------WGSSTGSS----- 313
                GS S  S G S  GS  G S +    R +SGS  S       +GS   SS     
Sbjct: 516 SYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQSSSYGPHGYGSGRSSSRGPYE 575

Query: 314 --SGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETS 351
             SG+      G GH+   E    ++ G G+ G  +  +S
Sbjct: 576 SGSGH----SSGLGHQ---ESRSGQSSGYGQHGSSSGHSS 608



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 101/369 (27%), Positives = 140/369 (37%), Gaps = 45/369 (12%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALGHGL-GDALSEGVGKAIGKEAGGAAGSKVSEALGQGT 75
            GS        G+  +G+   ++LGHG  G    +    + G+   G+  S      G G+
Sbjct: 2384 GSSSGSSSSYGQHGSGSR--QSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGS 2441

Query: 76   REAVGTGVRQVPGFGAADALGNRVGEAAHALG------NTGHE--------IGRQAEDVI 121
              +   G  +  G G +  LG+R   +  + G      ++GH            Q+    
Sbjct: 2442 GWSSSRGPYE-SGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCG 2500

Query: 122  RHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLG-GQGQGNPGGLGTPWVHGYPGNS 180
            +HGA + + S  G   H      S G+G  GS  G   G GQ   G   +P    +   S
Sbjct: 2501 QHGASSGQSSSHGQ--HGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGS 2558

Query: 181  AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240
              S      G+  G+    G     +    + +Q G GS  +S   +        GS  G
Sbjct: 2559 GRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQ-------HGSRSG 2611

Query: 241  SSNSGGGSGSQSGSS------GSG---SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSG 291
             S+ G   GS SGSS      GSG   S+G    GS SG S S    G   G SS  S G
Sbjct: 2612 QSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSS--SHG 2669

Query: 292  NSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGE--SGIQNSE 349
              G   G S S   + S  G SS   G    G+GH     + G+   GSG   S  Q+  
Sbjct: 2670 QHGSGSGRSSSRGPYESRLGHSS-VFGQHESGSGHSSAYSQHGS---GSGHFCSQGQHGS 2725

Query: 350  TSPGMFNFD 358
            TS     FD
Sbjct: 2726 TSGQSSTFD 2734



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 97/343 (28%), Positives = 137/343 (39%), Gaps = 39/343 (11%)

Query: 28   EESTGTNIGEALGH-GLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQV 86
            +E + T    + GH G G + S G G+       G + S+     G G   + G   +  
Sbjct: 1325 QEGSSTGQSSSYGHRGSGSSQSSGYGRH--GAGSGQSPSRGRHGSGSGHSSSYG---QHG 1379

Query: 87   PGFGAADALGNRVGEAAHALGNTGHEIGR-QAEDVIRHGADAVRGSWQGVPGHNGAWETS 145
             G G + + G     +  + G   HE    Q+    +HG+ +         GH+ ++E  
Sbjct: 1380 SGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGS---------GHSSSYEQH 1430

Query: 146  GGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFG 205
            G      S+G   G   G+    G    HG    S  S G    G+  GQ  +      G
Sbjct: 1431 GSRSGQSSRGERHGSSSGSSSSYGQ---HG--SGSRQSLGHGQHGSGSGQSPSPSRGRHG 1485

Query: 206  TNTQGAVAQPGYGSVRASNQNEG---CTNPPPSGSGGGSSNSGGGSG-SQSGSSGSGSNG 261
            + +  + +   YGS    + + G     +   SG G   S SG  SG  Q GSS   S+ 
Sbjct: 1486 SGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSST 1545

Query: 262  DNNNGSSSGGSSSGSSSGGSSGGSSG------GSSGNSGGSRGDSGSESSWG----SSTG 311
               +GS+SG SSS    G SSG SS       GSS +SG  R  SGS  S G     S  
Sbjct: 1546 HGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGS 1605

Query: 312  SSSGNHGGSGGGNGHKPGCEKPGNEARGSGE-SGIQNSETSPG 353
              S ++G  G G+G        G    G GE SG  + E+S G
Sbjct: 1606 RQSPSYGRHGSGSGRS---SSSGQHGSGLGESSGFGHHESSSG 1645



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 99/362 (27%), Positives = 140/362 (38%), Gaps = 37/362 (10%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGT 75
            GSG +     G    G+    + G HG G     G   + G+   G+  S  S   G G+
Sbjct: 1340 GSGSSQSSGYGRHGAGSGQSPSRGRHGSGS----GHSSSYGQHGSGSGWSSSSGRHGSGS 1395

Query: 76   REAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGV 135
             ++ G G  +   + ++    +  G    +          Q+    RHG+ +  GS    
Sbjct: 1396 GQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSS--GSSSSY 1453

Query: 136  PGHNGAWETSGGHGIFGSQGGLG--------GQGQG-----NPGGLGTPWVHG---YPGN 179
              H      S GHG  GS  G          G G G     +P G G+ W      Y   
Sbjct: 1454 GQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESG 1513

Query: 180  SAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE-GCTNPPPSGSG 238
            S+ S G+  + +  GQ    G     +       Q G  S ++S+  + G ++   S  G
Sbjct: 1514 SSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHG 1573

Query: 239  --GGSSNSGGGSGSQ-SGSSGSGSNGDNNNGSSSG------GSSSG-SSSGGSSGGSSGG 288
              G  S+   G G Q SGS  S  +G   +GS         GS SG SSS G  G   G 
Sbjct: 1574 QHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGE 1633

Query: 289  SS--GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ 346
            SS  G+   S G S S S  GS +G SSG +G  G  +G     E+ G+ +R S   G  
Sbjct: 1634 SSGFGHHESSSGQSSSYSQHGSGSGHSSG-YGQHGSRSGQSSRGERHGSSSRSSSRYGQH 1692

Query: 347  NS 348
             S
Sbjct: 1693 GS 1694



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 98/362 (27%), Positives = 141/362 (38%), Gaps = 37/362 (10%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGT 75
            GSG +     G++ +G+    + G HG G     G   + G+   G+  S  S   G G+
Sbjct: 2280 GSGSSQSSSYGQQGSGSGQSPSRGRHGSGS----GHSSSYGQHGSGSGWSSSSGRHGSGS 2335

Query: 76   REAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGV 135
             ++ G G  +   + ++    +  G    +          Q+    RHG+ +  GS    
Sbjct: 2336 GQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSS--GSSSSY 2393

Query: 136  PGHNGAWETSGGHGIFGSQGGLG--------GQGQG-----NPGGLGTPWVHG---YPGN 179
              H      S GHG  GS  G          G G G     +P G G+ W      Y   
Sbjct: 2394 GQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESG 2453

Query: 180  SAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE-GCTNPPPSGSG 238
            S  S G+  + +  GQ    G     +       Q G  S ++S+  + G ++   S  G
Sbjct: 2454 SGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHG 2513

Query: 239  --GGSSNSGGGSGSQ-SGSSGSGSNGDNNNGSSSG------GSSSG-SSSGGSSGGSSGG 288
              G  S+   G G Q SGS  S  +G   +GS         GS SG SSS G  G   G 
Sbjct: 2514 QHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGE 2573

Query: 289  SS--GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ 346
            SS  G+   S G S S S  GS +G SSG +G  G  +G     E+ G+ +  S   G  
Sbjct: 2574 SSGFGHHESSSGQSSSYSQHGSGSGHSSG-YGQHGSRSGQSSRGERHGSSSGSSSHYGQH 2632

Query: 347  NS 348
             S
Sbjct: 2633 GS 2634



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 75/280 (26%), Positives = 112/280 (40%), Gaps = 29/280 (10%)

Query: 64  GSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR-QAEDVIR 122
           G + S++     R   G+G  Q P +G     G+  G+++    N  H  G  Q+    +
Sbjct: 180 GEQNSDSHQSSGRGQCGSGSGQSPNYGQH---GSGSGQSS---SNDTHGSGSGQSSGFSQ 233

Query: 123 HGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG 182
           H + +  G   G   H      S G+G  GS+ G   +G+ +    G+            
Sbjct: 234 HKSSS--GQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGS------------ 279

Query: 183 SFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSS 242
                   + +GQ G+G   + G   QG+ ++     VR  + +   ++    GSG   S
Sbjct: 280 -------SSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYS 332

Query: 243 NSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGS 302
            S G   S SG +      ++ +G SSG S  GS SG SS     GS+     S G  GS
Sbjct: 333 YSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGS 392

Query: 303 ESSWGSSTGSSSGNHGGSGGGNGHKPGC-EKPGNEARGSG 341
            S   SS G        S G   H  G  + PG+  RGSG
Sbjct: 393 SSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSG 432



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 100/384 (26%), Positives = 142/384 (36%), Gaps = 62/384 (16%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALG-------HGLGDALSEGVGKAIGKEAGGAAGSKVSE 69
           G G+ G  +SG+ S G   G + G       HG G   S G  +      G  +G   S 
Sbjct: 490 GHGQHGS-RSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRH-----GSGSGQSPSP 543

Query: 70  ALGQ---GTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGR--QAEDVIRHG 124
           + G+   G+R++   G     G G + + G     + H+ G  GH+  R  Q+    +HG
Sbjct: 544 SRGRHESGSRQSSSYGPHGY-GSGRSSSRGPYESGSGHSSG-LGHQESRSGQSSGYGQHG 601

Query: 125 ADAVRGSWQGVPGHNGAWETS--------------GGHGIFGSQGGLGGQGQGNPGGLGT 170
           + +   S  G  G      +S              G HG   SQ    GQ     G   +
Sbjct: 602 SSSGHSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPS 661

Query: 171 PWVHGYPGNSAGSFGMNPQGAPW-----------GQGGNGGPPNFGTNTQGAVAQPGYGS 219
              HG     + S+G +  G+ W           GQ    G  + G+      +Q G GS
Sbjct: 662 RGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKS-GSGQSSGYSQHGSGS 720

Query: 220 VRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS--GSSGSGSN---GDNNNGSSSG---- 270
             +S   +  +    SG    S   G  SG  S  G  GSGS+   G    GS SG    
Sbjct: 721 SHSSGYRKHGSR---SGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPS 777

Query: 271 ----GSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH 326
               GSSSG SS     GS    S + G     SG  S +G     S   +   G  +GH
Sbjct: 778 RVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGFGQHESGSGQGYSQHGSASGH 837

Query: 327 KPGCEKPGNEARGSGESGIQNSET 350
                + G+ +  S  SG  +S +
Sbjct: 838 FSSQGRHGSTSGQSSSSGQHDSSS 861



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 97/370 (26%), Positives = 137/370 (37%), Gaps = 53/370 (14%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGT 75
            GSG +     G++ +G+    + G HG G     G   + G+   G+  S  S   G G+
Sbjct: 1810 GSGSSQSSSYGQQGSGSGQSPSRGRHGSGS----GHSSSYGQHGSGSGWSSSSGRHGSGS 1865

Query: 76   REAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGV 135
             ++ G G  +   + ++    +  G    +          Q+    +HG+ +  GS    
Sbjct: 1866 GQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSS--GSSSSY 1923

Query: 136  PGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWG- 194
              H      S GHG  GS     G GQ      G    HG     + S+G    G+ W  
Sbjct: 1924 GQHGSGSRQSLGHGQHGS-----GSGQSPSPSRGR---HGSGSGQSSSYGPYGSGSGWSS 1975

Query: 195  -----QGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249
                 + G+G     G     +    GYG   +S+ +        S SG  SS    G+ 
Sbjct: 1976 SRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGAS 2035

Query: 250  S-------QSGSSGSGSNGDNNNGSSSG---------------------GSSSG-SSSGG 280
            S       Q GS  S S+G    GS SG                     GS SG SSS G
Sbjct: 2036 SGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSG 2095

Query: 281  SSGGSSGGSS--GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEAR 338
              G   G SS  G+   S G S S S  GS +G SSG +G  G  +G     E+ G+ + 
Sbjct: 2096 QHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG-YGQHGSRSGQSSRGERHGSSSG 2154

Query: 339  GSGESGIQNS 348
             S   G   S
Sbjct: 2155 SSSRYGQHGS 2164



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 96/352 (27%), Positives = 136/352 (38%), Gaps = 45/352 (12%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTR 76
           GSG +   + G++ +G+    + G    D    G   + G+   G+  S  +   G  + 
Sbjct: 640 GSGSSQSSRYGQQGSGSGQSPSRGRHGSDF---GHSSSYGQHGSGSGWSSSNGPHGSVSG 696

Query: 77  EAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVP 136
           ++         GFG     G   G + H  G++ H  G +     +HG+ + + S     
Sbjct: 697 QS--------SGFGHKSGSGQSSGYSQHGSGSS-HSSGYR-----KHGSRSGQSSRSEQH 742

Query: 137 GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWV-HGYPGNSAGSFGMNPQGAPWG- 194
           G +    +S G    GS    G   QG+  G     V HG     + S G +  G     
Sbjct: 743 GSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSS 802

Query: 195 -----QGGNGGPPNFGTNTQGA---VAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGG 246
                + G+G    FG +  G+    +Q G  S   S+Q          GS  G S+S G
Sbjct: 803 SCGHYESGSGQASGFGQHESGSGQGYSQHGSASGHFSSQGR-------HGSTSGQSSSSG 855

Query: 247 GSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSW 306
              S SG S S    ++ +  +SG    GS SG S G    GS      S G  GS    
Sbjct: 856 QHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGS---- 911

Query: 307 GSSTGSSSGNHGGSGGGN----GHKPGC-EKPGNEARGSGESGIQNSETSPG 353
           GS   SSSG H GSG G     GHK    +  G    GSG SG  +S    G
Sbjct: 912 GSGRSSSSGRH-GSGSGQSSGFGHKSSSGQSSGYTQHGSG-SGHSSSYEQHG 961



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 57/170 (33%), Positives = 74/170 (43%), Gaps = 16/170 (9%)

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG 253
           GQ  + G  N  ++      Q G GS ++ N  +        GSG G S+S    GS SG
Sbjct: 174 GQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQ-------HGSGSGQSSSNDTHGSGSG 226

Query: 254 SSGSGSNGDNNNGSSSGGSSSGSSSGGSSG----GSSGGSSGNSGGSRGDSGSESSWG-- 307
            S   S   +++G SSG S  GS SG SSG    GS  G S      R  SGS SS+G  
Sbjct: 227 QSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQH 286

Query: 308 SSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNF 357
            S    S  HG  G G+   P   + G+   GSG S       S   +++
Sbjct: 287 GSGSRQSLGHGRQGSGSRQSPSHVRHGS---GSGHSSSHGQHGSGSSYSY 333



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 87/331 (26%), Positives = 128/331 (38%), Gaps = 58/331 (17%)

Query: 47  LSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAA--H 104
           L +   K IGK+    +GSK+ +   Q   E   T   +           N+  E++  H
Sbjct: 81  LVQARNKIIGKDYCQVSGSKLRDDTHQHQEEQEETEKEE-----------NKRQESSFSH 129

Query: 105 ALGNTGHE--IGRQAEDVIRHGADAV--RGSWQ-GVPGHNGAWETSGGHGIFGSQGGLGG 159
           +  + G      R     ++ G +++  R S+Q    G + ++  SG    +G Q     
Sbjct: 130 SSWSAGENDSYSRNVRGSLKPGTESISRRLSFQRDFSGQHNSY--SGQSSSYGEQNSDSH 187

Query: 160 QGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGS 219
           Q  G           G  G+ +G      Q   +GQ G+G   +   +T G+ +    G 
Sbjct: 188 QSSGR----------GQCGSGSG------QSPNYGQHGSGSGQSSSNDTHGSGSGQSSGF 231

Query: 220 VRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSG 279
            +  + +   +     GSG G S+  G  GS+SG S  G    +++GSSS     GS S 
Sbjct: 232 SQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSR 291

Query: 280 GSSG-GSSG------------GSSGNSGGSRGDSGSESSWGSSTG---SSSGNHGGSG-- 321
            S G G  G            GS      S G  GS SS+  S G   S SG   G G  
Sbjct: 292 QSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQH 351

Query: 322 -GGNGHKPGCEKPGNEARGSGESGIQNSETS 351
             G+G   G  K G+   GSG S  Q    S
Sbjct: 352 ESGSGQSSGYSKHGS---GSGHSSSQGQHGS 379



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 53/166 (31%), Positives = 66/166 (39%), Gaps = 13/166 (7%)

Query: 193 WGQGGNGGPPNFGTNTQGAVAQPGYGSV--RASNQNE--GCTNPPPSGSGG-GSSNSGGG 247
           W  G N    ++  N +G++ +PG  S+  R S Q +  G  N     S   G  NS   
Sbjct: 132 WSAGEND---SYSRNVRGSL-KPGTESISRRLSFQRDFSGQHNSYSGQSSSYGEQNSDSH 187

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWG 307
             S  G  GSGS    N G    GS SG SS   + GS  G S  SG S+  S S  S G
Sbjct: 188 QSSGRGQCGSGSGQSPNYGQH--GSGSGQSSSNDTHGSGSGQS--SGFSQHKSSSGQSSG 243

Query: 308 SSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
            S   S   H    G +G + G    G   R S  S     +   G
Sbjct: 244 YSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSG 289


>gi|55956899 keratin 9 [Homo sapiens]
          Length = 623

 Score =  103 bits (256), Expect = 3e-22
 Identities = 70/196 (35%), Positives = 75/196 (38%), Gaps = 45/196 (22%)

Query: 146 GGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFG 205
           GG   F S G  G  G G  GG G  +  G  G S GS+G          GG+GG     
Sbjct: 460 GGQEDFESSGA-GKIGLGGRGGSGGSYGRGSRGGSGGSYG---------GGGSGG----- 504

Query: 206 TNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNN 265
                                         G GGGS + GG  GS  G SGSG       
Sbjct: 505 ------------------------------GYGGGSGSRGGSGGSYGGGSGSGGGSGGGY 534

Query: 266 GSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNG 325
           G  SGG  SG S GG SGGS G   G SG   G  G       S G S G+HGG  G  G
Sbjct: 535 GGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGG 594

Query: 326 HKPGCEKPGNEARGSG 341
              G    G EA GSG
Sbjct: 595 ESGGSYGGGEEASGSG 610



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 52/113 (46%), Positives = 55/113 (48%), Gaps = 3/113 (2%)

Query: 235 SGSGG-GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS 293
           SG+G  G    GG  GS    S  GS G    G S GG   GS S G SGGS GG SG+ 
Sbjct: 468 SGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSG 527

Query: 294 GGSRGDSGSESSWGSSTGSSSGNHGGSGG--GNGHKPGCEKPGNEARGSGESG 344
           GGS G  G  S  G S GS  G+ GGSGG  G G   G    G    GSG  G
Sbjct: 528 GGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRG 580



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 65/182 (35%), Positives = 79/182 (43%), Gaps = 14/182 (7%)

Query: 119 DVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPG 178
           +++  G +    S  G  G  G   + G +G  GS+GG GG   G   G G     G  G
Sbjct: 456 NLLEGGQEDFESSGAGKIGLGGRGGSGGSYGR-GSRGGSGGSYGGGGSGGGYGGGSGSRG 514

Query: 179 NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSG 238
            S GS+G    G+  G GG  G  + G ++ G+    G G    S  N G       GSG
Sbjct: 515 GSGGSYG-GGSGSGGGSGGGYGGGSGGGHSGGS----GGGHSGGSGGNYG------GGSG 563

Query: 239 GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG 298
            G   SGGG G  SGS G GS G +  GS  GG S GS  GG     SGG  G   G   
Sbjct: 564 SGG-GSGGGYGGGSGSRG-GSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGKSS 621

Query: 299 DS 300
            S
Sbjct: 622 HS 623



 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 48/121 (39%), Positives = 57/121 (47%), Gaps = 15/121 (12%)

Query: 236 GSGGGSSNSGGGS-GSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSS-----------G 283
           G GG   + G GS G   GS G G +G    G S     SG S GG S           G
Sbjct: 477 GRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGG 536

Query: 284 GSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGES 343
           GS GG SG SGG     GS  ++G  +GS  G+ GG GGG+G + G    G+   GSG  
Sbjct: 537 GSGGGHSGGSGGGH-SGGSGGNYGGGSGSGGGSGGGYGGGSGSRGG--SGGSHGGGSGFG 593

Query: 344 G 344
           G
Sbjct: 594 G 594



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 56/154 (36%), Positives = 65/154 (42%), Gaps = 25/154 (16%)

Query: 195 QGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG----SSNSGGGSGS 250
           + G GG    G+           GS+R+S      +     G GGG    SS  GGGS  
Sbjct: 13  RSGGGGGGGLGSG----------GSIRSSYSRFSSSG---GGGGGGRFSSSSGYGGGSSR 59

Query: 251 QSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGS------SGGSSGNSGGSRG--DSGS 302
             G  G GS G +  G S GG S+ S  GG  GGS      SGG   +SGG  G    GS
Sbjct: 60  VCGRGGGGSFGYSYGGGSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGS 119

Query: 303 ESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNE 336
              +G   GS  G  GG GGG G   G     NE
Sbjct: 120 GGGFGGGYGSGFGGFGGFGGGAGGGDGGILTANE 153



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 51/121 (42%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 236 GSGGG---------SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSS 286
           GSGG          SS  GGG G  S SSG G       G   GGS   S  GGS GG S
Sbjct: 23  GSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGYSYGGGSGGGFS 82

Query: 287 GGSSGNS--GGSRGDSG-SESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGES 343
             S G    GGSRG  G S   + SS G   G  GGSGGG G   G    G    G G  
Sbjct: 83  ASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAG 142

Query: 344 G 344
           G
Sbjct: 143 G 143



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 41/97 (42%), Positives = 45/97 (46%), Gaps = 3/97 (3%)

Query: 251 QSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSG--GSSGNSGGSRGDSGSESSWGS 308
           + G     S+G    G    G S GS   GS GGS G  G  G+ GG  G SGS    G 
Sbjct: 459 EGGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGG 518

Query: 309 STGSSSGNHGGSGGGNGHKPGCEKPGNEARG-SGESG 344
           S G  SG+ GGSGGG G   G    G    G SG SG
Sbjct: 519 SYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSG 555



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 46/114 (40%), Positives = 49/114 (42%), Gaps = 11/114 (9%)

Query: 242 SNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSG--SSSGGSSGGSS-------GGSSGN 292
           S SGGG G   GS GS  +  +   SS GG   G  SSS G  GGSS       GGS G 
Sbjct: 12  SRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGY 71

Query: 293 S--GGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESG 344
           S  GGS G   + S  G   G S G  G SGGG     G         G G  G
Sbjct: 72  SYGGGSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGG 125



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 50/171 (29%), Positives = 60/171 (35%), Gaps = 50/171 (29%)

Query: 127 AVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQ-----GQGNPGGLGTPWVHGYPGNSA 181
           ++R S+       G     GG G F S  G GG      G+G  G  G    + Y G S 
Sbjct: 27  SIRSSYSRFSSSGGG----GGGGRFSSSSGYGGGSSRVCGRGGGGSFG----YSYGGGSG 78

Query: 182 GSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGS 241
           G F  +  G  +G G  G    FG                               SGGG 
Sbjct: 79  GGFSASSLGGGFGGGSRG----FG-----------------------------GASGGGY 105

Query: 242 SNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGN 292
           S+SGG  G   G SG G  G    G  SG    G   GG+ GG  G  + N
Sbjct: 106 SSSGGFGGGFGGGSGGGFGG----GYGSGFGGFGGFGGGAGGGDGGILTAN 152



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 40/108 (37%), Positives = 45/108 (41%), Gaps = 15/108 (13%)

Query: 252 SGSSGSGSNGDNNNGSSSGG------SSSGSSSGGSSGGSSGGSSGNSGGS-----RGDS 300
           S S  S S G    G  SGG      S   SS GG  GG    SSG  GGS     RG  
Sbjct: 7   SSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGG 66

Query: 301 GSES-SWGSSTG---SSSGNHGGSGGGNGHKPGCEKPGNEARGSGESG 344
           GS   S+G  +G   S+S   GG GGG+    G    G  + G    G
Sbjct: 67  GSFGYSYGGGSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGG 114



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 36/132 (27%), Positives = 51/132 (38%), Gaps = 3/132 (2%)

Query: 40  GHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRV 99
           G G G ++     +      GG  G + S + G G   +   G      FG +   G+  
Sbjct: 21  GLGSGGSIRSSYSR-FSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGYSYGGGSGG 79

Query: 100 GEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGI-FGSQGGLG 158
           G +A +LG  G   G +       G  +  G + G  G        GG+G  FG  GG G
Sbjct: 80  GFSASSLGG-GFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGGFG 138

Query: 159 GQGQGNPGGLGT 170
           G   G  GG+ T
Sbjct: 139 GGAGGGDGGILT 150



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 37/141 (26%), Positives = 45/141 (31%), Gaps = 17/141 (12%)

Query: 19  GEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREA 78
           G  G    G    G   G     G G +   G G   G   G   GS    + G G   +
Sbjct: 492 GSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHS 551

Query: 79  VGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGH 138
            G+G     G G+    G   G      G +G           R G+    G   G  G 
Sbjct: 552 GGSGGNYGGGSGSGGGSGGGYG------GGSGS----------RGGSGGSHGGGSGFGGE 595

Query: 139 NGAWETSGGHGIFGSQGGLGG 159
           +G     GG    GS GG GG
Sbjct: 596 SGG-SYGGGEEASGSGGGYGG 615



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 30/79 (37%), Positives = 31/79 (39%), Gaps = 5/79 (6%)

Query: 272 SSSGSSSGGSSGGSSG-GSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGS----GGGNGH 326
           SS  S SGG  GG  G G S  S  SR  S      G    SSSG  GGS    G G G 
Sbjct: 8   SSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGG 67

Query: 327 KPGCEKPGNEARGSGESGI 345
             G    G    G   S +
Sbjct: 68  SFGYSYGGGSGGGFSASSL 86


>gi|109255251 loricrin [Homo sapiens]
          Length = 312

 Score =  101 bits (252), Expect = 1e-21
 Identities = 91/249 (36%), Positives = 100/249 (40%), Gaps = 52/249 (20%)

Query: 137 GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQG 196
           G  G     GG G FG  GG GG   G+  G G     GY G   G       G   G G
Sbjct: 23  GGGGGGSGGGGCGFFGG-GGSGGGSSGS--GCGYSGGGGYSGGGCG-------GGSSGGG 72

Query: 197 GNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSG----GGSSNSGGGSGSQS 252
           G GG    G  + G+V   G G   +S    GC +    GSG    GG  +SGGGSG  S
Sbjct: 73  GGGGIGGCGGGSGGSVKYSGGGG--SSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFS 130

Query: 253 GSSGSGSNGDNNNGSSSGGSSSG------SSSGGSSGGSSGGSSG--NSGGSRGD----- 299
              G  S G +   SS GG  SG      S  G SSGGSSGG SG  +SGG  G      
Sbjct: 131 SGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYS 190

Query: 300 -SGSESSWGSSTGSSSG------------------NHGGSGGGNGHKPGCEKP----GNE 336
             GS    GSS GS SG                    G SGGG     GC       G+ 
Sbjct: 191 GGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSS 250

Query: 337 ARGSGESGI 345
             G G SGI
Sbjct: 251 GCGGGSSGI 259



 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 88/268 (32%), Positives = 104/268 (38%), Gaps = 29/268 (10%)

Query: 89  FGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGH 148
           FG   + G   G      G  G+  G         G     G   G  G  G+ + SGG 
Sbjct: 37  FGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGG--GSGGSVKYSGGG 94

Query: 149 GIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTN- 207
           G  G   G    G G  G   +    G  G+S G  G    G     GG  G  + G   
Sbjct: 95  GSSGGGSGCFSSGGGGSGCFSS----GGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGG 150

Query: 208 -TQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGS--SNSGGGSGSQSGSSGSGSNGDNN 264
            +  AV    YG V +   + G +    SG GGGS    SGGGSG   GSSG   +G  +
Sbjct: 151 FSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVS 210

Query: 265 N-----------GSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSS 313
           +            S  GGSS G  SGGS   SSGG  G+SG   G SG  S    S G S
Sbjct: 211 SQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGS 270

Query: 314 SGNHGGSGGGNGHKPGCEKPGNEARGSG 341
               G SGGG G        G+   GSG
Sbjct: 271 VCGGGSSGGGGG--------GSSVGGSG 290



 Score = 92.4 bits (228), Expect = 6e-19
 Identities = 79/238 (33%), Positives = 95/238 (39%), Gaps = 26/238 (10%)

Query: 130 GSWQGVPGHNGAWETSGGHGIFGSQGGLGGQ-----GQGNPGGLGTPWVHGYPGN---SA 181
           G + G     G+    GG GI G  GG GG      G G+ GG    +  G  G+   S+
Sbjct: 57  GGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSS 116

Query: 182 GSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGS 241
           G  G +  G+     G GG    G+    +      G         G ++   SG G G 
Sbjct: 117 GGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGC 176

Query: 242 SNSGGGSGSQSGSSGSGSN--GDNNNGSSSGGSSS----------------GSSSGGSSG 283
            +SGGG GS  G SG GS   G ++ GS SG  SS                GSS GG SG
Sbjct: 177 FSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSG 236

Query: 284 GSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSG 341
           GS   SSG  GGS G  G  S  GS    S G     GG +G   G    G    G G
Sbjct: 237 GSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKG 294



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 55/132 (41%), Positives = 59/132 (44%), Gaps = 13/132 (9%)

Query: 229 CTNPPPSGSGGGSSNSGG-----GSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSG 283
           C      G GGG S  GG     G GS  GSSGSG  G +  G  SGG   G SSGG  G
Sbjct: 16  CVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGC-GYSGGGGYSGGGCGGGSSGGGGG 74

Query: 284 GSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGS-------GGGNGHKPGCEKPGNE 336
           G  GG  G SGGS   SG   S G  +G  S   GGS       GG +G   GC   G  
Sbjct: 75  GGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGG 134

Query: 337 ARGSGESGIQNS 348
               G SG  +S
Sbjct: 135 GSSGGGSGCFSS 146



 Score = 85.5 bits (210), Expect = 7e-17
 Identities = 77/207 (37%), Positives = 85/207 (41%), Gaps = 27/207 (13%)

Query: 143 ETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPP 202
           +TSGG G     GG GG G G  GG              G  G    G+  G  G GG  
Sbjct: 18  KTSGGGG---GGGGSGGGGCGFFGG--------------GGSGGGSSGSGCGYSGGGGYS 60

Query: 203 NFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGD 262
             G    G+    G G +       G +      SGGG S+ GG     SG  GSG    
Sbjct: 61  GGGCG-GGSSGGGGGGGIGGCGGGSGGS---VKYSGGGGSSGGGSGCFSSGGGGSGCFSS 116

Query: 263 NNNGSSSGGSSSGSS-SGGSSGGSSGGSSGNSGGSRGDSGSESSWG--SSTGSSSGNHG- 318
              GSS GGS   SS  GGSSGG SG  S   GG  G +    S+G  SS GSS G  G 
Sbjct: 117 GGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGC 176

Query: 319 -GSGGGNGHKPGCEKPGNEARGSGESG 344
             SGGG G   G    G    G G SG
Sbjct: 177 FSSGGGGGSVCG-YSGGGSGCGGGSSG 202



 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 90/281 (32%), Positives = 108/281 (38%), Gaps = 29/281 (10%)

Query: 40  GHGLGDALSEGVGKAI---GKEAGGAAGSKVSEALGQG-TREAVGTGVRQVPGFGAADAL 95
           G G G   S G G      G   GG++GS    + G G +    G G     G G     
Sbjct: 21  GGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGC 80

Query: 96  GNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQG 155
           G   G +    G  G   G         G  +  G   G     G   + GG G F S G
Sbjct: 81  GGGSGGSVKYSGGGGSSGGGS-------GCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGG 133

Query: 156 GL---GGQGQGNPGGLG----TPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNF--GT 206
           G    GG G  + GG G          Y G S+G       G     GG G    +  G 
Sbjct: 134 GGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGG 193

Query: 207 NTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG-----SQSGSSGSGSNG 261
           +  G  +  G GS   S+Q    T+  P  S GG S+ GGGSG     S  G  GS   G
Sbjct: 194 SGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCG 253

Query: 262 DNNNGSSSGGSSSGSSS---GGSSGGSSGGSS-GNSGGSRG 298
             ++G  SG   SG  S   GGSSGG  GGSS G SG  +G
Sbjct: 254 GGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKG 294



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 64/167 (38%), Positives = 70/167 (41%), Gaps = 27/167 (16%)

Query: 212 VAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSG----GGSGSQSGSSGSGSNGDNNN-- 265
           V   G G     +   GC      GSGGGSS SG    GG G   G  G GS+G      
Sbjct: 17  VKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGG 76

Query: 266 ----GSSSGGSSSGSSSGGSSGG-----SSGG------SSGNSGGSRGDSGSESSWGSST 310
               G  SGGS   S  GGSSGG     SSGG      SSG  G S G SG  SS G   
Sbjct: 77  IGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGG-- 134

Query: 311 GSSSGNHG----GSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
           GSS G  G    G GG +G    C+  G  + G    G     +S G
Sbjct: 135 GSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGG 181



 Score = 37.4 bits (85), Expect = 0.023
 Identities = 62/247 (25%), Positives = 79/247 (31%), Gaps = 70/247 (28%)

Query: 15  CLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEG---VGKAIGKEAGGAAGSKVSEAL 71
           C  SG  G    G     +  G + G G G   S G    G+A+  ++ G   S  S   
Sbjct: 113 CFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGG 172

Query: 72  GQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGS 131
           G G   + G G   V G+      G+  G  +     +G+   +Q              S
Sbjct: 173 GSGCFSSGGGG-GSVCGYSGG---GSGCGGGSSGGSGSGYVSSQQVTQT----------S 218

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGA 191
               P + G   +SGG       GG GG G  + GG G                      
Sbjct: 219 CAPQPSYGGG--SSGG-------GGSGGSGCFSSGGGG---------------------- 247

Query: 192 PWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQ 251
             G  G GG               G GS        GC         GG S+ GGG GS 
Sbjct: 248 --GSSGCGG------------GSSGIGS--------GCIISGGGSVCGGGSSGGGGGGSS 285

Query: 252 SGSSGSG 258
            G SGSG
Sbjct: 286 VGGSGSG 292


>gi|4826734 fusion (involved in t(12;16) in malignant liposarcoma)
           [Homo sapiens]
          Length = 526

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 73/226 (32%), Positives = 95/226 (42%), Gaps = 28/226 (12%)

Query: 144 TSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPN 203
           ++GG+G   S     GQ    PG    P     P +++GS+G + Q + +GQ      P 
Sbjct: 77  STGGYGSSQSSQSSYGQQSSYPGYGQQP----APSSTSGSYGSSSQSSSYGQ------PQ 126

Query: 204 FGTNTQGAVAQPGYGSVRASNQNEGCTNPPP---------SGSGGGSSNSGGGSGSQ--- 251
            G+ +Q    QP YG  + S   +   NPP          S SGGG    GGG+  Q   
Sbjct: 127 SGSYSQ----QPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQS 182

Query: 252 SGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG 311
           S SSG GS G   N   SGG  SG       GG   G SG  GG  G   + SS G    
Sbjct: 183 SMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPR 242

Query: 312 SSSGNHGGSGG-GNGHKPGCEK-PGNEARGSGESGIQNSETSPGMF 355
              G  GG GG G   + G  K  G   +GS     Q++  +  +F
Sbjct: 243 GRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIF 288



 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 52/154 (33%), Positives = 60/154 (38%), Gaps = 17/154 (11%)

Query: 152 GSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGA 211
           G   G GG+G+G P G G     GY G  +G  G    G P G GG GG    G      
Sbjct: 378 GGGNGRGGRGRGGPMGRG-----GYGGGGSGGGGRG--GFPSGGGGGGGQQRAG---DWK 427

Query: 212 VAQPGYGSVRASNQNE--GCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSS 269
              P   ++  S +NE   C  P P G GGG    G   G   G    G  G  + G   
Sbjct: 428 CPNPTCENMNFSWRNECNQCKAPKPDGPGGGPG--GSHMGGNYGDDRRGGRGGYDRGGYR 485

Query: 270 GGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSE 303
           G    G   GG  GG  GG  G  G  + DS  E
Sbjct: 486 G---RGGDRGGFRGGRGGGDRGGFGPGKMDSRGE 516



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 67/278 (24%), Positives = 97/278 (34%), Gaps = 39/278 (14%)

Query: 29  ESTGTN-IGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVP 87
           +ST T+  G++     G + + G G     +  G+ G   S    Q ++ + G      P
Sbjct: 43  QSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSS---QSSQSSYGQQ-SSYP 98

Query: 88  GFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGG 147
           G+G   A  +  G    +  ++ +                  GS+   P + G  ++ G 
Sbjct: 99  GYGQQPAPSSTSGSYGSSSQSSSY-------------GQPQSGSYSQQPSYGGQQQSYGQ 145

Query: 148 HGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTN 207
              +    G G Q Q N    G     G  G   G++G +      G G  GG  N   +
Sbjct: 146 QQSYNPPQGYGQQNQYNSSSGG-----GGGGGGGGNYGQDQSSMSSGGGSGGGYGN--QD 198

Query: 208 TQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGS 267
             G     GYG      +  G       GSGGG    GGG G    S G    G    G 
Sbjct: 199 QSGGGGSGGYGQQDRGGRGRG-------GSGGGG--GGGGGGYNRSSGGYEPRG---RGG 246

Query: 268 SSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESS 305
             GG   G   G   GG +        GSR DS  ++S
Sbjct: 247 GRGG--RGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNS 282



 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 52/175 (29%), Positives = 67/175 (38%), Gaps = 17/175 (9%)

Query: 192 PWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSG-----GGSSNSGG 246
           P+GQ    G     T+T G   Q  Y S   S      T   P G G     G S +S  
Sbjct: 32  PYGQQSYSGYSQ-STDTSG-YGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQS 89

Query: 247 GSGSQSGSSGSGSNGDNNNGSSSGG--SSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSES 304
             G QS   G G     +  S+SG   SSS SSS G     S     + GG +   G + 
Sbjct: 90  SYGQQSSYPGYGQQPAPS--STSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQ 147

Query: 305 S------WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
           S      +G     +S + GG GGG G   G ++    + G    G  N + S G
Sbjct: 148 SYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGG 202



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 51/161 (31%), Positives = 66/161 (40%), Gaps = 16/161 (9%)

Query: 206 TNTQGAV-AQPGYGSVRASNQNEG-------CTNPPPSGSGGGSSNSGG-----GSGSQS 252
           T + GA   QPG G  + S+Q  G         +   SG G  S +S G     G G+QS
Sbjct: 11  TQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQS 70

Query: 253 GSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGS 312
              G GS G   +  SS  S    SS    G     SS  + GS G S   SS+G    S
Sbjct: 71  TPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSS--TSGSYGSSSQSSSYGQPQ-S 127

Query: 313 SSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
            S +   S GG     G ++  N  +G G+    NS +  G
Sbjct: 128 GSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGG 168



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 38/140 (27%), Positives = 48/140 (34%), Gaps = 14/140 (10%)

Query: 196 GGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSS 255
           GGNG     G    G + + GYG   +             G GG  S  GGG G Q    
Sbjct: 379 GGNG---RGGRGRGGPMGRGGYGGGGSGG----------GGRGGFPSGGGGGGGQQRAGD 425

Query: 256 GSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS-GGSRGDSGSESSWGSSTGSSS 314
               N    N + S  +           G  GG  G+  GG+ GD       G   G   
Sbjct: 426 WKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYR 485

Query: 315 GNHGGSGGGNGHKPGCEKPG 334
           G  G  GG  G + G ++ G
Sbjct: 486 GRGGDRGGFRGGRGGGDRGG 505



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 79/359 (22%), Positives = 110/359 (30%), Gaps = 69/359 (19%)

Query: 40  GHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRV 99
           G+G  +  +   G   G   GG  G   S ++  G     G G +   G G +   G + 
Sbjct: 154 GYGQQNQYNSSSGGGGGGGGGGNYGQDQS-SMSSGGGSGGGYGNQDQSGGGGSGGYGQQ- 211

Query: 100 GEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGG 159
                  G +G   G               G   G    +G +E  G  G  G +GG+GG
Sbjct: 212 DRGGRGRGGSGGGGG---------------GGGGGYNRSSGGYEPRGRGGGRGGRGGMGG 256

Query: 160 QGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFG----------TNTQ 209
             +G     G P   G   +S      N      G G N    +            TN +
Sbjct: 257 SDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKK 316

Query: 210 GAVAQPGYGSVRASNQNEG----CTNPPPSGSGG-----GSSNSGG-------------G 247
                    + R + + +G      + PPS         G   SG               
Sbjct: 317 TGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFN 376

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG-SSGGSSGGSSGNSGGSRGDS----GS 302
            G  +G  G G  G    G   GG S G   GG  SGG  GG    +G  +  +      
Sbjct: 377 RGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENM 436

Query: 303 ESSWGSS---------TGSSSGNHGGSGGGN------GHKPGCEKPGNEARGSGESGIQ 346
             SW +           G   G  G   GGN      G + G ++ G   RG    G +
Sbjct: 437 NFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFR 495



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 83/381 (21%), Positives = 120/381 (31%), Gaps = 51/381 (13%)

Query: 18  SGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQ---- 73
           +G  G  QS + S G       G+G   A S   G         + G   S +  Q    
Sbjct: 78  TGGYGSSQSSQSSYGQQSSYP-GYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSY 136

Query: 74  -GTREAVGTGVRQVP--GFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRG 130
            G +++ G      P  G+G  +   +  G      G  G   G+    +   G      
Sbjct: 137 GGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGG--GGGGGNYGQDQSSMSSGG------ 188

Query: 131 SWQGVPGHNGAWETSGGHGIFG-SQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQ 189
              G  G  G  + SGG G  G  Q   GG+G+G  GG G     GY  +S G       
Sbjct: 189 ---GSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRG 245

Query: 190 GAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGG-- 247
           G   G+GG GG    G N  G     G    R  ++ +   N      G G + +     
Sbjct: 246 GGRGGRGGMGGSDRGGFNKFGGPRDQG---SRHDSEQDNSDNNTIFVQGLGENVTIESVA 302

Query: 248 ----------SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGN--SGG 295
                     +  ++G        D   G   G ++       S+  +     G   SG 
Sbjct: 303 DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGN 362

Query: 296 -------------SRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGE 342
                        +RG        G       G +GG G G G + G    G    G   
Sbjct: 363 PIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQR 422

Query: 343 SGIQNSETSPGMFNFDTFWKN 363
           +G      +P   N +  W+N
Sbjct: 423 AGDWKC-PNPTCENMNFSWRN 442


>gi|195972866 keratin 10 [Homo sapiens]
          Length = 584

 Score = 91.3 bits (225), Expect = 1e-18
 Identities = 56/131 (42%), Positives = 63/131 (48%), Gaps = 12/131 (9%)

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG 253
           G+G +GG    G +  G     GYG   +   + G       G GGG   S GG G   G
Sbjct: 455 GEGSSGGGGRGGGSFGG-----GYGGGSSGGGSSG------GGHGGGHGGSSGG-GYGGG 502

Query: 254 SSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSS 313
           SSG GS+G    G SS G   GSSSGG  GGSSGG  G  GG     GS S  G   GSS
Sbjct: 503 SSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSGGGSSSGGGYGGGSS 562

Query: 314 SGNHGGSGGGN 324
           SG H  S  G+
Sbjct: 563 SGGHKSSSSGS 573



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 54/129 (41%), Positives = 64/129 (49%), Gaps = 8/129 (6%)

Query: 227 EGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGG-- 284
           EG  +    G GGGS   G G GS  G S  G +G  + GSS GG   GSS GGSSGG  
Sbjct: 454 EGEGSSGGGGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGY 513

Query: 285 ----SSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGS 340
               SSGG  G+S G  G   S    G   G SSG  GGS  G G+  G    G+++  S
Sbjct: 514 GGGSSSGGHGGSSSGGYGGGSSGGGGGGYGGGSSG--GGSSSGGGYGGGSSSGGHKSSSS 571

Query: 341 GESGIQNSE 349
           G  G  +S+
Sbjct: 572 GSVGESSSK 580



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 60/163 (36%), Positives = 68/163 (41%), Gaps = 41/163 (25%)

Query: 152 GSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGA 211
           GS GG GG+G G+ GG       GY G S+G  G +  G   G GG+ G           
Sbjct: 457 GSSGG-GGRGGGSFGG-------GYGGGSSGG-GSSGGGHGGGHGGSSGG---------- 497

Query: 212 VAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGG 271
               GYG                  SGGGSS  G G GS SG  G  S+G    GSS GG
Sbjct: 498 ----GYGG---------------GSSGGGSSGGGYGGGSSSGGHGGSSSGGYGGGSSGGG 538

Query: 272 SSS---GSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG 311
                 GSS GGSS G   G   +SGG +  S       SS G
Sbjct: 539 GGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKG 581



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 60/162 (37%), Positives = 72/162 (44%), Gaps = 41/162 (25%)

Query: 144 TSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPN 203
           +SGG G  G   G GG G G+ GG          G+S G  G          GG+GG   
Sbjct: 458 SSGGGGRGGGSFG-GGYGGGSSGG----------GSSGGGHG----------GGHGGS-- 494

Query: 204 FGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDN 263
                    +  GYG   +   + G       G  GG S+SGG  GS SG  G GS+G  
Sbjct: 495 ---------SGGGYGGGSSGGGSSG-------GGYGGGSSSGGHGGSSSGGYGGGSSGGG 538

Query: 264 NNGSSSGGSSSGSSSGGSSGG--SSGGSSGNSGGSRGDSGSE 303
             G   G S  GSSSGG  GG  SSGG   +S GS G+S S+
Sbjct: 539 GGGYGGGSSGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSK 580



 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 56/131 (42%), Positives = 62/131 (47%), Gaps = 8/131 (6%)

Query: 219 SVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSS 278
           SVR S+     ++    G GGG    GGG  S   SS  GS G    G SSGG S GS S
Sbjct: 2   SVRYSSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLG---GGFSSGGFSGGSFS 58

Query: 279 GGSSGGSS-GGSSGNSGGSRGDSGS--ESSWGSST--GSSSGNHGGSGGGNGHKPGCEKP 333
            GSSGG   GGSSG  GG  G  G     S+GSS+  GS  G+ GG   G G   G    
Sbjct: 59  RGSSGGGCFGGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGGSFG 118

Query: 334 GNEARGSGESG 344
           G    G G  G
Sbjct: 119 GGGFGGGGFGG 129



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 58/150 (38%), Positives = 67/150 (44%), Gaps = 17/150 (11%)

Query: 235 SGSGGGSSNSGGGSG-------SQSGSSGSG-SNGDNNNGSSSGGSSSGSSSGGSSGGSS 286
           SG GGG    GGG G       S  GS G G S+G  + GS S GSS G   GGSSGG  
Sbjct: 16  SGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGG-Y 74

Query: 287 GGSSGNSGGS-RGDSGSESSWGSSTGSSSGNH-------GGSGGGNGHKPGCEKPGNEAR 338
           GG  G  GGS RG  GS S  GS  GS  G         GGS GG G   G    G    
Sbjct: 75  GGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGGSFGGGGFGGGGFGGGFGGG 134

Query: 339 GSGESGIQNSETSPGMFNFDTFWKNFKSKL 368
             G+ G+ +      M N +    ++  K+
Sbjct: 135 FGGDGGLLSGNEKVTMQNLNDRLASYLDKV 164



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 45/132 (34%), Positives = 50/132 (37%), Gaps = 9/132 (6%)

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG 253
           G GG GG    G            GS+     + G +    S    G    GG SG   G
Sbjct: 17  GGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYGG 76

Query: 254 SSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSS 313
             G G       G S  GS   SS GGS GGS GG  G+ GG     GS    G   G  
Sbjct: 77  LGGFG-------GGSFRGSYGSSSFGGSYGGSFGG--GSFGGGSFGGGSFGGGGFGGGGF 127

Query: 314 SGNHGGSGGGNG 325
            G  GG  GG+G
Sbjct: 128 GGGFGGGFGGDG 139



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 43/145 (29%), Positives = 55/145 (37%), Gaps = 20/145 (13%)

Query: 153 SQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNP-QGAPWGQGGNGGPPNFGTNT-QG 210
           S GG GG G G  GG+ +  +    G+  G F      G  + +G +GG    G++   G
Sbjct: 16  SGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGGCFGGSSGGYG 75

Query: 211 AVAQPGYGSVRASNQNEGCTNPPPSGSGGGS---SNSGGGSGSQSGSSGSGSNGDNNNGS 267
            +   G GS R S  +           GGGS    + GGGS                 G 
Sbjct: 76  GLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFGGGS---------------FGGG 120

Query: 268 SSGGSSSGSSSGGSSGGSSGGSSGN 292
             GG   G   GG  GG  G  SGN
Sbjct: 121 GFGGGGFGGGFGGGFGGDGGLLSGN 145



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 31/76 (40%), Positives = 33/76 (43%), Gaps = 5/76 (6%)

Query: 280 GSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGG--NGHKPGCEKPGNEA 337
           GSSGG  G   G+ GG  G  G  S  GSS G   G HGGS GG   G   G    G   
Sbjct: 457 GSSGGG-GRGGGSFGGGYG--GGSSGGGSSGGGHGGGHGGSSGGGYGGGSSGGGSSGGGY 513

Query: 338 RGSGESGIQNSETSPG 353
            G   SG     +S G
Sbjct: 514 GGGSSSGGHGGSSSGG 529



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 36/124 (29%), Positives = 45/124 (36%), Gaps = 46/124 (37%)

Query: 137 GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQG 196
           G +G   + GG+G   S GG GG   G           GY G S+G           G G
Sbjct: 502 GSSGGGSSGGGYGGGSSSGGHGGSSSG-----------GYGGGSSGG----------GGG 540

Query: 197 GNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSG 256
           G GG  + G ++ G                         G  GG S+SGG   S SGS G
Sbjct: 541 GYGGGSSGGGSSSG-------------------------GGYGGGSSSGGHKSSSSGSVG 575

Query: 257 SGSN 260
             S+
Sbjct: 576 ESSS 579



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 44/156 (28%), Positives = 60/156 (38%), Gaps = 24/156 (15%)

Query: 46  ALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHA 105
           +L EG G + G   GG  G       G G+     +G     G G +   G   G  +  
Sbjct: 451 SLLEGEGSSGG---GGRGGGSFGGGYGGGSSGGGSSGGGHGGGHGGSS--GGGYGGGSSG 505

Query: 106 LGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNP 165
            G++G   G               GS  G  GH G+  +SGG+G  GS GG GG   G  
Sbjct: 506 GGSSGGGYGG--------------GSSSG--GHGGS--SSGGYG-GGSSGGGGGGYGGGS 546

Query: 166 GGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGP 201
            G G+    GY G S+     +      G+  + GP
Sbjct: 547 SGGGSSSGGGYGGGSSSGGHKSSSSGSVGESSSKGP 582



 Score = 36.6 bits (83), Expect = 0.039
 Identities = 34/107 (31%), Positives = 41/107 (38%), Gaps = 22/107 (20%)

Query: 145 SGGHGIFGSQGG-LGGQGQGNPGGLGTPWVHGYPGNS-AGSFGMNPQGAPWGQGGNGGPP 202
           SGG    GS GG   G   G  GGLG     G+ G S  GS+G +  G  +G    GG  
Sbjct: 53  SGGSFSRGSSGGGCFGGSSGGYGGLG-----GFGGGSFRGSYGSSSFGGSYGGSFGGGSF 107

Query: 203 NFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249
             G+   G+    G+G                 G GGG     GG G
Sbjct: 108 GGGSFGGGSFGGGGFGG---------------GGFGGGFGGGFGGDG 139



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 31/100 (31%), Positives = 37/100 (37%), Gaps = 4/100 (4%)

Query: 272 SSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG--SSSGNHGGSGGGNGHKPG 329
           SSS   S   SGG  GG     GG        SS GS  G  SS G  GGS        G
Sbjct: 6   SSSKHYSSSRSGGGGGGGGCGGGGGVSSLRISSSKGSLGGGFSSGGFSGGSFSRGSSGGG 65

Query: 330 CEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSKLG 369
           C   G  + G G  G     +  G +   +F  ++    G
Sbjct: 66  CF--GGSSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGSFG 103



 Score = 32.7 bits (73), Expect = 0.57
 Identities = 44/176 (25%), Positives = 56/176 (31%), Gaps = 58/176 (32%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTR 76
           G G  G    G  S G + G   GHG G   S G G   G   GG++G            
Sbjct: 465 GGGSFGGGYGGGSSGGGSSGG--GHGGGHGGSSGGGYGGGSSGGGSSGG----------- 511

Query: 77  EAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVP 136
                      G+G   + G                          HG  +  G   G  
Sbjct: 512 -----------GYGGGSSSGG-------------------------HGGSSSGGYGGGSS 535

Query: 137 GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAP 192
           G  G     GG+G  GS GG    G G  GG  +    G+  +S+GS G +    P
Sbjct: 536 GGGG-----GGYG-GGSSGGGSSSGGGYGGGSSS---GGHKSSSSGSVGESSSKGP 582



 Score = 31.2 bits (69), Expect = 1.7
 Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 9/84 (10%)

Query: 144 TSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNS--AGSFGMNPQGAPWGQGGNGGP 201
           +SGG+G  G  GG   +G       G  +   + G S   GSFG    G  +G GG GG 
Sbjct: 70  SSGGYGGLGGFGGGSFRGSYGSSSFGGSYGGSFGGGSFGGGSFG----GGSFGGGGFGG- 124

Query: 202 PNFGTNTQGAVAQPGYGSVRASNQ 225
             FG    G     G G + + N+
Sbjct: 125 GGFGGGFGGGFG--GDGGLLSGNE 146



 Score = 28.9 bits (63), Expect = 8.2
 Identities = 27/77 (35%), Positives = 32/77 (41%), Gaps = 17/77 (22%)

Query: 124 GADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGS 183
           G  + RGS+ G     G++  S G G FG  GG  G G    GG G            G 
Sbjct: 81  GGGSFRGSY-GSSSFGGSYGGSFGGGSFG--GGSFGGGSFGGGGFG-----------GGG 126

Query: 184 FGMNPQGAPWGQGGNGG 200
           FG    G   G GG+GG
Sbjct: 127 FG---GGFGGGFGGDGG 140


>gi|62122917 filaggrin family member 2 [Homo sapiens]
          Length = 2391

 Score = 89.0 bits (219), Expect = 7e-18
 Identities = 102/357 (28%), Positives = 135/357 (37%), Gaps = 59/357 (16%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKE---AGGAAGSKVSEALG 72
            GSG +     G+  +G+      G HG G   S G G+   +    + G  GS  S++ G
Sbjct: 798  GSGSSQSTGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSG 857

Query: 73   QGTREAVGTGVRQVPGFGA-ADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGS 131
             G     G+   Q  GFG    + G   G   H  G+       Q+    +HG  +  G 
Sbjct: 858  YGQH---GSSSGQTSGFGQHRSSSGQYSGFGQHGSGSG------QSSGFGQHGTGS--GQ 906

Query: 132  WQGVPGHNGAWETS--GGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQ 189
            + G   H      S  G HG   SQ    G GQ           HG        FG +  
Sbjct: 907  YSGFGQHESRSHQSSYGQHGSGSSQSS--GYGQ-----------HGSSSGQTFGFGQHRS 953

Query: 190  GAPWGQG------GNGGPPNFGTNTQGAVAQPGYGS--VRASNQNEGCTNPPPSGSGGGS 241
            G+    G      G+G    FG +  G+    G+G    R+S  N G       GSG   
Sbjct: 954  GSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSNYG-----QHGSGSSQ 1008

Query: 242  SNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSG-GSSGGSSGNSGG----- 295
            S+  G  GS SG +       +++G  SG    GS S  SSG G  G  SG S G     
Sbjct: 1009 SSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYE 1068

Query: 296  --SRGDSGSESSWGSSTGSSSGNHGGSGGGNG----HKPGCEKP---GNEARGSGES 343
              SR  S  +   GSS  S  G HG + G       H+PG  +    G    GSG+S
Sbjct: 1069 SRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQS 1125



 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 106/356 (29%), Positives = 142/356 (39%), Gaps = 54/356 (15%)

Query: 17  GSGEAGPLQS-GEESTGTNIGEALG---HGLGDALSEGVGKAIGKEAGGAAGSKVSEALG 72
           G  E+   QS G +  G++ G+  G   HG G   S G G+         +GS  S   G
Sbjct: 454 GQHESTSSQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQC-------GSGSGQSSGFG 506

Query: 73  QGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSW 132
           Q      G+   Q  GFG   ++  +      + G   HE   +     +HG+ + + S 
Sbjct: 507 QH-----GSVSGQSSGFGQHGSVSGQ------SSGFGQHESRSRQSSYGQHGSGSSQSSG 555

Query: 133 QGVPGHNGAWETSG--GHGIFGSQG---GLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMN 187
            G     G+ ETSG   HG+   Q    G  G G G   G G    HG     +  FG +
Sbjct: 556 YG---QYGSRETSGFGQHGLGSGQSTGFGQYGSGSGQSSGFGQ---HGSGSGQSSGFGQH 609

Query: 188 PQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGG 247
                       G  ++G ++ G+    GYG    S Q  G       GSG   S   G 
Sbjct: 610 ES--------RSGQSSYGQHSSGSSQSSGYGQ-HGSRQTSGFGQ---HGSGSSQSTGFGQ 657

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSG-GSSGNSG-GSRGDS-GSES 304
            GS SG S       + +G SSG     S SG SS G  G GSS +SG G  G S G  S
Sbjct: 658 YGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSSYGQHGFGSSQSSGYGQHGSSSGQTS 717

Query: 305 SWGSSTGSS--SGNHGGSGGGNGHKPGCEKPGNEARGSGE-SGIQNSETSPGMFNF 357
            +G    SS  S + G  G G+G   G    G    GSG+ SG    E+  G  ++
Sbjct: 718 GFGQHELSSGQSSSFGQHGSGSGQSSGF---GQHGSGSGQSSGFGQHESRSGQSSY 770



 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 113/421 (26%), Positives = 154/421 (36%), Gaps = 93/421 (22%)

Query: 16  LGSGEAGPLQSGEESTGTNIGEALG---HGLGDALSEGVGK--------AIGKEAGGAA- 63
           LGSG++    +G    G+  G++ G   HG G   S G G+        + G+ + G++ 
Sbjct: 572 LGSGQS----TGFGQYGSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQ 627

Query: 64  -------GSKVSEALGQ-GTREAVGTGVRQV-PGFGAADALGNRVGEAAHALGNTGHEIG 114
                  GS+ +   GQ G+  +  TG  Q   G G +   G  V  +  + G   HE  
Sbjct: 628 SSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESR 687

Query: 115 RQAEDVIRHGADAVRGSWQGVPGHN-GAWETSGGHGIFGSQG---GLGGQGQGNPGGLGT 170
                  +HG  + + S  G  G + G     G H +   Q    G  G G G   G G 
Sbjct: 688 SGHSSYGQHGFGSSQSSGYGQHGSSSGQTSGFGQHELSSGQSSSFGQHGSGSGQSSGFGQ 747

Query: 171 PWVHGYPGNSAGSFGMNP----------------QGAPWGQGGNGGPPNFGTNTQGAVAQ 214
              HG     +  FG +                 Q + +GQ G+     FG +  G+   
Sbjct: 748 ---HGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQS 804

Query: 215 PGYGSVRASNQNEGCTNPPPSGSGGGS------SNSGGGSGSQSGSSGSGSNGDNNNGSS 268
            G+G   + +          SGSG  S      S S   S  Q GS  S S+G   +GSS
Sbjct: 805 TGFGQYGSGSGQSAGFGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSS 864

Query: 269 SGGSSS-----------------GSSSGGSSG-GSSGGSSGNSGG-------SRGDSGSE 303
           SG +S                  GS SG SSG G  G  SG   G       S   S  +
Sbjct: 865 SGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSHQSSYGQ 924

Query: 304 SSWGSSTGSSSGNHGGSGG----------GNGHKPGCEKPGNEARGSGE-SGIQNSETSP 352
              GSS  S  G HG S G          G+G   G    G    GSG+ SG    E+  
Sbjct: 925 HGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGF---GQHGSGSGQSSGFGQHESGS 981

Query: 353 G 353
           G
Sbjct: 982 G 982



 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 101/361 (27%), Positives = 149/361 (41%), Gaps = 50/361 (13%)

Query: 26   SGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQ 85
            SG    G++ G+  G G  + LS G   + G+     +GS  S   GQ      G+G  Q
Sbjct: 704  SGYGQHGSSSGQTSGFGQHE-LSSGQSSSFGQHG---SGSGQSSGFGQH-----GSGSGQ 754

Query: 86   VPGFGAADALGNRVGEAAHALGNT-----GHEIGRQAEDVIRHGADAVRGSWQGVPGHNG 140
              GFG  ++   +     H+ G++     G    RQ     +HG+ + + +  G  G +G
Sbjct: 755  SSGFGQHESRSGQSSYGQHSSGSSQSSGYGQHGSRQTSGFGQHGSGSSQSTGFGQYG-SG 813

Query: 141  AWETSGGHGIFGSQGGLGGQGQG-------------NPGGLGTPWVHGYP--GNSAGS-- 183
            + +++G    FG  G   GQ  G                G G+    GY   G+S+G   
Sbjct: 814  SGQSAG----FGQHGSGSGQSSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTS 869

Query: 184  -FGMNP----QGAPWGQGGNGGPPN--FGTNTQGAVAQPGYG-----SVRASNQNEGCTN 231
             FG +     Q + +GQ G+G   +  FG +  G+    G+G     S ++S    G  +
Sbjct: 870  GFGQHRSSSGQYSGFGQHGSGSGQSSGFGQHGTGSGQYSGFGQHESRSHQSSYGQHGSGS 929

Query: 232  PPPSGSGGGSSNSGGGSGSQSGSSGSG-SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSS 290
               SG G   S+SG   G     SGSG S+G   +GS SG SS        SG SSG   
Sbjct: 930  SQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQ 989

Query: 291  GNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSET 350
              S  S+ + G   S GSS  S  G HG S G             +  G G+ G  + ++
Sbjct: 990  HESRSSQSNYGQHGS-GSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQS 1048

Query: 351  S 351
            S
Sbjct: 1049 S 1049



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 101/373 (27%), Positives = 162/373 (43%), Gaps = 62/373 (16%)

Query: 17  GSGEAGPLQS--GEESTGTNIGEALG-HGLGDALSEGVGK----AIGKEAGGAAGSKVSE 69
           G+ E G  Q+  G+  TG++     G +G G + S   G+    + G+ +  ++ ++ S+
Sbjct: 356 GARENGQPQNCGGQWRTGSSQSSCCGQYGSGGSQSCSNGQHEYGSCGRFSNSSSSNEFSK 415

Query: 70  A--LGQGTREAV-----GTGVRQVPGF-----GAADALGNRVGEAAHALGNTGH-EIGRQ 116
               G G+ ++      GTG+ Q  GF     G+    G     ++ +LG   H     +
Sbjct: 416 CDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCGSGQTCGQHESTSSQSLGYDQHGSSSGK 475

Query: 117 AEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQG-----NPGGLGTP 171
                +HG+ + + S  G  G +G+ ++SG    FG  G + GQ  G     +  G  + 
Sbjct: 476 TSGFGQHGSGSGQSSGFGQCG-SGSGQSSG----FGQHGSVSGQSSGFGQHGSVSGQSSG 530

Query: 172 WVHGYPGNSAGSFGMNPQGAP----WGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE 227
           +      +   S+G +  G+     +GQ G+     FG +  G+    G+G         
Sbjct: 531 FGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFGQHGLGSGQSTGFGQY------- 583

Query: 228 GCTNPPPSGSGGGSSNSGGGSGSQSG-SSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSS 286
                   GSG G S+  G  GS SG SSG G +   +  SS G  SSGSS   SSG   
Sbjct: 584 --------GSGSGQSSGFGQHGSGSGQSSGFGQHESRSGQSSYGQHSSGSSQ--SSGYGQ 633

Query: 287 GGSSGNSGGSRGDSGSESS-----WGSSTGSSSG---NHGGSGGGNGHKPGCEKPGNEAR 338
            GS   SG  +  SGS  S     +GS +G SSG   +  GSG  +G      + G+ + 
Sbjct: 634 HGSRQTSGFGQHGSGSSQSTGFGQYGSGSGQSSGFGQHVSGSGQSSGFGQHESRSGHSS- 692

Query: 339 GSGESGIQNSETS 351
             G+ G  +S++S
Sbjct: 693 -YGQHGFGSSQSS 704



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 99/368 (26%), Positives = 148/368 (40%), Gaps = 50/368 (13%)

Query: 27   GEESTGTNIGEALG-HGLGDALSEGVGK---AIGKEAG-GAAGSKVSEALGQGTREAVGT 81
            G+  +G++     G HG     + G G+   + G+ +G G  GS   ++ G G     GT
Sbjct: 846  GQHGSGSSQSSGYGQHGSSSGQTSGFGQHRSSSGQYSGFGQHGSGSGQSSGFGQH---GT 902

Query: 82   GVRQVPGFGAADALGNRVGEAAHALGNT--------GHEIGR------------QAEDVI 121
            G  Q  GFG  ++  ++     H  G++        G   G+            Q+    
Sbjct: 903  GSGQYSGFGQHESRSHQSSYGQHGSGSSQSSGYGQHGSSSGQTFGFGQHRSGSGQSSGFG 962

Query: 122  RHGADAVRGSWQGVPGHNGAWETSG--GHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGN 179
            +HG+ + + S  G    +G+ ++SG   H    SQ   G  G G+    G    +G  G+
Sbjct: 963  QHGSGSGQSSGFG-QHESGSGKSSGFGQHESRSSQSNYGQHGSGSSQSSG----YGQHGS 1017

Query: 180  SAGS---FGMNP----QGAPWGQGGNGGPPN--FGTNTQGAVAQPGYG-----SVRASNQ 225
            S+G    FG +     Q + +GQ G+G   +  FG +  G+    G+G     S ++S  
Sbjct: 1018 SSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQSSGFGQYESRSRQSSYG 1077

Query: 226  NEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGS 285
              G  +   SG G   SNSG  SG      GSG +       S  G SSG    GS  G 
Sbjct: 1078 QHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGSGSGQSSGFGQHGSGTGK 1137

Query: 286  SGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGI 345
            S G + +   S   S  +   GSS  S  G H  SG G     G    G++   S    I
Sbjct: 1138 SSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQH-ESGSGPTTSFGQHVSGSDNFSSSGQHI 1196

Query: 346  QNSETSPG 353
             +S  S G
Sbjct: 1197 SDSGQSTG 1204



 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 90/361 (24%), Positives = 130/361 (36%), Gaps = 33/361 (9%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTR 76
            GSG++    SG    GT  G+  G G  ++ S     + G+   G++ S      G  + 
Sbjct: 890  GSGQS----SGFGQHGTGSGQYSGFGQHESRSHQ--SSYGQHGSGSSQSSGYGQHGSSSG 943

Query: 77   EAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVP 136
            +  G G  +  G G +   G     +  + G   HE G         G    R S     
Sbjct: 944  QTFGFGQHR-SGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGF--GQHESRSSQSNYG 1000

Query: 137  GHNGAWETSGGHGIFGSQGGLG---GQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPW 193
             H      S G+G  GS  G     GQ + + G       HG   + +  FG +  G+  
Sbjct: 1001 QHGSGSSQSSGYGQHGSSSGQTTGFGQHRSSSGQYSGFGQHGSGSDQSSGFGQHGTGSGQ 1060

Query: 194  GQG-----GNGGPPNFGTNTQGAVAQPGYGSVRA-SNQNEGC-TNPPPSGSGGGSSNSGG 246
              G           ++G +  G+    GYG   + S Q  G   + P SG   G    G 
Sbjct: 1061 SSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHRPGSGQSSGFGQYGS 1120

Query: 247  GSGSQSG----SSGSGSN----------GDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGN 292
            GSG  SG     SG+G +          G ++ G    GSS  S  G    GS   +S  
Sbjct: 1121 GSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCGQHESGSGPTTSFG 1180

Query: 293  SGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSP 352
               S  D+ S S    S    S   G  G G+G   G  +  ++   SG +     ET+ 
Sbjct: 1181 QHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVESGSTVHGRQETTH 1240

Query: 353  G 353
            G
Sbjct: 1241 G 1241



 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 96/356 (26%), Positives = 131/356 (36%), Gaps = 38/356 (10%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGK---AIGKEAG------------ 60
            GS        G+  +G+      G HG G   S G G+     GK +G            
Sbjct: 939  GSSSGQTFGFGQHRSGSGQSSGFGQHGSGSGQSSGFGQHESGSGKSSGFGQHESRSSQSN 998

Query: 61   -GAAGSKVSEALGQGTREAVGTGVRQVPGFGA-ADALGNRVGEAAHALGNTGHEIGRQAE 118
             G  GS  S++ G G     G+   Q  GFG    + G   G   H  G+       Q+ 
Sbjct: 999  YGQHGSGSSQSSGYGQH---GSSSGQTTGFGQHRSSSGQYSGFGQHGSGSD------QSS 1049

Query: 119  DVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPG 178
               +HG  + + S  G         + G HG   SQ    GQ   N G       H  PG
Sbjct: 1050 GFGQHGTGSGQSSGFGQYESRSRQSSYGQHGSGSSQSSGYGQHGSNSGQTSGFGQHR-PG 1108

Query: 179  NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSG 238
            +   S G    G+  GQ    G    GT      AQ  Y S ++S    G  +   SG G
Sbjct: 1109 SGQSS-GFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQSSGCG 1167

Query: 239  GGSSNSGGGSG---SQSGSSGSGSNGD--NNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS 293
               S SG  +      SGS    S+G   +++G S+G    GS SG S+G   G S    
Sbjct: 1168 QHESGSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGESQQVE 1227

Query: 294  GGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSE 349
             GS      E++ G +  ++   H  SG G   + G        R S +S   +SE
Sbjct: 1228 SGSTVHGRQETTHGQTINTT--RHSQSGQGQSTQTGSRV--TRRRRSSQSENSDSE 1279



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 89/330 (26%), Positives = 119/330 (36%), Gaps = 39/330 (11%)

Query: 19   GEAGPLQSGEESTGTNIGEALGHG-LGDALSE-GVGKAIGKEAGGAAGSKVSEALGQGTR 76
            G +G  QS +  + T    A GH    D+    GV       A G AGS+  E+ G    
Sbjct: 2008 GHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSHTHSGHAHGQAGSQHGES-GSSVH 2066

Query: 77   EAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVP 136
            E  GT              G       HA    G    R +    R G+     S   V 
Sbjct: 2067 ERHGT------------THGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSDSEV- 2113

Query: 137  GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQG 196
             H+G   T  GH    ++   G  G    G  GT  +HG  G++             GQ 
Sbjct: 2114 -HSGVSHTHSGHTYGQARSQHGESGSAIHGRQGT--IHGQTGDTTRH----------GQS 2160

Query: 197  GNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSG 256
            G+G     G+ T G        S   S+ +E  +   P+ SG   S +G   G QSGSSG
Sbjct: 2161 GHGQSTQTGSRTTGRQRS----SHSESSDSEVHSEASPTHSGHTHSQAGSRHG-QSGSSG 2215

Query: 257  SGSNGDNNN--GSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSS 314
             G  G  +   G ++  +  G       G  + G  G SG S        SWGS T   S
Sbjct: 2216 HGRQGTTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRG-SGHSESSDSEVHSWGSHT--HS 2272

Query: 315  GNHGGSGGGNGHKPGCEKPGNEARGSGESG 344
            G+  G  G    +PG    G      G++G
Sbjct: 2273 GHIQGQAGSQQRQPGSTVHGRLETTHGQTG 2302



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 106/413 (25%), Positives = 147/413 (35%), Gaps = 92/413 (22%)

Query: 25  QSGEE---STGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGT 81
           +SGEE    +G+N  E  GHG    LS G+ +  G E+         + LG     +  +
Sbjct: 218 ESGEEYESGSGSNSWERKGHG---GLSCGL-ETSGHESNSTQSRIREQKLGSSCSGSGDS 273

Query: 82  GVRQ-VPGFGAADALGNRVGEAA----HALGNTGHEI-----GRQAEDVIRHGADAVRGS 131
           G R    G+  +   G     ++    H  G  G++      G Q+      G   V G 
Sbjct: 274 GRRSHACGYSNSSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSG- 332

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPW-----------VHGYPGNS 180
             G P   G  E++     + SQ G G +  G P   G  W            +G  G+ 
Sbjct: 333 --GQPSGCGQPESNPCSQSY-SQRGYGARENGQPQNCGGQWRTGSSQSSCCGQYGSGGSQ 389

Query: 181 AGSFGMNPQGAPWGQGGNGGPPN-----------------FGTNTQGAVAQPGY-----G 218
           + S G +  G+  G+  N    N                 F  +  G     G+     G
Sbjct: 390 SCSNGQHEYGS-CGRFSNSSSSNEFSKCDQYGSGSSQSTSFEQHGTGLSQSSGFEQHVCG 448

Query: 219 SVRASNQNEGCTNPP--------PSGSGGGSSNSGGGSGSQSG----SSGSGSNGDNNNG 266
           S +   Q+E  ++           SG   G    G GSG  SG     SGSG +      
Sbjct: 449 SGQTCGQHESTSSQSLGYDQHGSSSGKTSGFGQHGSGSGQSSGFGQCGSGSGQSSGFGQH 508

Query: 267 SSSGGSSSGSSSGGSSGGSSGG-------SSGNSGGSRGDSGSESS----WGSSTGSSSG 315
            S  G SSG    GS  G S G       S  +S G  G   S+SS    +GS   S  G
Sbjct: 509 GSVSGQSSGFGQHGSVSGQSSGFGQHESRSRQSSYGQHGSGSSQSSGYGQYGSRETSGFG 568

Query: 316 NHG-GS---------GGGNGHKPGCEKPGNEARGSGE-SGIQNSETSPGMFNF 357
            HG GS         G G+G   G    G    GSG+ SG    E+  G  ++
Sbjct: 569 QHGLGSGQSTGFGQYGSGSGQSSGF---GQHGSGSGQSSGFGQHESRSGQSSY 618



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 77/335 (22%), Positives = 112/335 (33%), Gaps = 52/335 (15%)

Query: 24   LQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGV 83
            +Q+G  +TG   G             GV         G AGS   E+ G    E  GT  
Sbjct: 1941 IQTGSRTTGRR-GSGHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPES-GSSVHERHGT-- 1996

Query: 84   RQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWE 143
                        G       H  G++GH    Q          +    +    GH+G   
Sbjct: 1997 ----------THGQTADTTRH--GHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSH 2044

Query: 144  TSGGH--GIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSA----GSFGMNPQ--GAPWGQ 195
            T  GH  G  GSQ G  G       G      HG  G++        G + Q      G+
Sbjct: 2045 THSGHAHGQAGSQHGESGSSVHERHGT----THGQTGDTTRHAHSGHGQSTQRGSRTAGR 2100

Query: 196  GGNGGPPNFGTNTQGAVAQPG----YGSVRASNQNEGCTNPPPSGSGGGSSN-------S 244
             G+G   +  +     V+       YG  R+ +   G       G+  G +        S
Sbjct: 2101 RGSGHSESSDSEVHSGVSHTHSGHTYGQARSQHGESGSAIHGRQGTIHGQTGDTTRHGQS 2160

Query: 245  GGGSGSQSGSSGSGSNGDNNNGSS------------SGGS-SSGSSSGGSSGGSSGGSSG 291
            G G  +Q+GS  +G    +++ SS            SG + S   S  G SG S  G  G
Sbjct: 2161 GHGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGHTHSQAGSRHGQSGSSGHGRQG 2220

Query: 292  NSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH 326
             + G  GD+   + +G    +  G+      G+GH
Sbjct: 2221 TTHGQTGDTTRHAHYGYGQSTQRGSRTTGRRGSGH 2255



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 98/433 (22%), Positives = 147/433 (33%), Gaps = 107/433 (24%)

Query: 17   GSGEAGPLQSGEESTGTNIGEALG---HGLGDALSEGVGK---AIGKEAGGAAGSKVSEA 70
            GSG++    SG    G+  G++ G   HG G   S G  +     G+ + G  G+  S++
Sbjct: 1108 GSGQS----SGFGQYGSGSGQSSGFGQHGSGTGKSSGFAQHEYRSGQSSYGQHGTGSSQS 1163

Query: 71   LGQGTREAVGTGV-----RQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGA 125
             G G  E+ G+G      + V G     + G  + ++  + G   +  G      +  G 
Sbjct: 1164 SGCGQHES-GSGPTTSFGQHVSGSDNFSSSGQHISDSGQSTGFGQYGSGSGQSTGLGQGE 1222

Query: 126  DAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLG---------------- 169
                 S   V G     ET+ G  I  ++    GQGQ    G                  
Sbjct: 1223 SQQVESGSTVHGRQ---ETTHGQTINTTRHSQSGQGQSTQTGSRVTRRRRSSQSENSDSE 1279

Query: 170  ---------TPWVHGYPGN---SAGSFGMNPQGAPWGQGGNG---GPPNFGTNTQGAVAQ 214
                     +  +H   G+    +GS     QG   GQ G+    G    G +TQ     
Sbjct: 1280 VHSKVSHRHSEHIHTQAGSHYPKSGSTVRRRQGTTHGQRGDTTRHGHSGHGQSTQTGSRT 1339

Query: 215  PG-----YGSVRASNQNEGCTNPPPS------------------------------GSGG 239
             G     +     S  + G ++ P S                              G   
Sbjct: 1340 SGRQRFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHERHETTYGQTGEAT 1399

Query: 240  GSSNSGGGSGSQSGSSGSGSNGDNNNGSS-----SGGS----------SSGSSSGGSSGG 284
            G  +SG G  +Q GS  +G  G  ++ SS     SGGS              S  G SG 
Sbjct: 1400 GHGHSGHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQSQEQTHGQAGSQHGESGS 1459

Query: 285  SSGGSSGNSGGSRGDSGSESSW--GSST--GSSSGNHGGSGGGNGHKPGCEKPGNEARGS 340
            +  G  G + G  GD+   + +  G ST  GSS+    GSG            G+     
Sbjct: 1460 TVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGRRGSGHSESSDSEVHSGGSHTHSG 1519

Query: 341  ---GESGIQNSET 350
               G+SG Q+ E+
Sbjct: 1520 HTHGQSGSQHGES 1532



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 92/382 (24%), Positives = 131/382 (34%), Gaps = 61/382 (15%)

Query: 17   GSGEAGPLQSGEESTGTN---IGEALGH---GLGDALSEGVGKAIGKEAGGAAGSKVSEA 70
            GS    P  +  E  GT    IG+  GH   G G +   G  +  G++    + S  SE 
Sbjct: 1603 GSQHEEPEFTVHERHGTTHGQIGDTTGHSHSGHGQSTQRG-SRTTGRQRSSHSESSDSE- 1660

Query: 71   LGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHG------ 124
                    V +GV            G++ G++   +         Q  D  RH       
Sbjct: 1661 --------VHSGVSHTHTGHTHGQAGSQHGQSESIVPERHGTTHGQTGDTTRHAHYHHGL 1712

Query: 125  --ADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAG 182
                  R + +   GH+   ++ G  G+  +  G       +  G     VH   G   G
Sbjct: 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIHG 1772

Query: 183  SFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPS------- 235
              G   + A     G+G     G+ T G  +  G+     S  + G +  P S       
Sbjct: 1773 QTGDTTRHA---HSGHGQSTQTGSRTTGRRSS-GHSEYSDSEGHSGFSQRPHSRGHTHGQ 1828

Query: 236  -GSGGGSSNS-------------GGGSG-SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG 280
             GS  G S S             G  SG SQSG   S  +G +  G    G S  S S  
Sbjct: 1829 AGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSESSDSEV 1888

Query: 281  SSGGS---SGGSSGNSGGSRGDSGS-----ESSWGSSTGSSSGNHGGSGGGNGHKPGCEK 332
             SGGS   SG +   +    G+S S       +    TG ++  HG    G   + G   
Sbjct: 1889 HSGGSHTHSGHTHSQARSQHGESESTVHKRHQTTHGQTGDTT-EHGHPSHGQTIQTGSRT 1947

Query: 333  PGNEARGSGESGIQNSETSPGM 354
             G   RGSG S   +SE   G+
Sbjct: 1948 TGR--RGSGHSEYSDSEGPSGV 1967



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 85/348 (24%), Positives = 115/348 (33%), Gaps = 37/348 (10%)

Query: 19   GEAGPLQSGEESTGTNIGEALGHG-LGDAL-----SEGVGKAIGKEAGGAAGSKVSEALG 72
            G+AG  Q GE  +  +      HG  GD         G     G    G  GS  SE+  
Sbjct: 2052 GQAGS-QHGESGSSVHERHGTTHGQTGDTTRHAHSGHGQSTQRGSRTAGRRGSGHSESSD 2110

Query: 73   QGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSW 132
                  V +       +G A +     G A H    T H    Q  D  RHG      S 
Sbjct: 2111 SEVHSGV-SHTHSGHTYGQARSQHGESGSAIHGRQGTIHG---QTGDTTRHGQ-----SG 2161

Query: 133  QGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGN---SAGSFGMNPQ 189
             G     G+  T                 + +P   G    H   G+    +GS G   Q
Sbjct: 2162 HGQSTQTGSRTTGRQRSSHSESSDSEVHSEASPTHSGH--THSQAGSRHGQSGSSGHGRQ 2219

Query: 190  GAPWGQGGNG---GPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPS-GSGGGSSNSG 245
            G   GQ G+        +G +TQ      G    R S  +E   +   S GS   S +  
Sbjct: 2220 GTTHGQTGDTTRHAHYGYGQSTQRGSRTTGR---RGSGHSESSDSEVHSWGSHTHSGHIQ 2276

Query: 246  GGSGSQSGSSGSGSNG--DNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSE 303
            G +GSQ    GS  +G  +  +G +   +  G S  G S   +G  S  +   +  S   
Sbjct: 2277 GQAGSQQRQPGSTVHGRLETTHGQTGDTTRHGHSGYGQST-QTGSRSSRASHFQSHSSER 2335

Query: 304  SSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETS 351
               GSS     G++G +    GH       G    G     I NS  S
Sbjct: 2336 QRHGSSQVWKHGSYGPAEYDYGH------TGYGPSGGSRKSISNSHLS 2377



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 76/330 (23%), Positives = 109/330 (33%), Gaps = 50/330 (15%)

Query: 40   GHGLGDALSE-GVGKAIGKEAGGAAGSKVSEALG-------QGTREAVGTGVRQVPGFGA 91
            GH  G A S+ G  ++I  E  G    +  +  G       Q T+    T  R+  G   
Sbjct: 1823 GHTHGQAGSQHGESESIVDERHGTTHGQTGDTSGHSQSGHGQSTQSGSSTTGRRRSGHSE 1882

Query: 92   ADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGAD--AVRGSWQGVPGHNGAWETSGGHG 149
            +           H+ G+  H     ++   +HG     V    Q   G  G   T  GH 
Sbjct: 1883 SS------DSEVHSGGSHTHSGHTHSQARSQHGESESTVHKRHQTTHGQTGD-TTEHGHP 1935

Query: 150  IFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNP--QGAPWGQGGNGGPPNFGTN 207
              G     G +  G  G       H    +S G  G++    G   GQ G+  P +    
Sbjct: 1936 SHGQTIQTGSRTTGRRGS-----GHSEYSDSEGPSGVSHTHSGHTHGQAGSHYPES---- 1986

Query: 208  TQGAVAQPGYGSVR---ASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNN 264
              G+     +G+     A     G +    S   G  +     SG    S   G +G ++
Sbjct: 1987 --GSSVHERHGTTHGQTADTTRHGHSGHGQSTQRGSRTTGRRASGHSEYSDSEGHSGVSH 2044

Query: 265  NGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGN 324
              S      +GS  G  SG S     G + G  GD              +  H  SG G 
Sbjct: 2045 THSGHAHGQAGSQHG-ESGSSVHERHGTTHGQTGD--------------TTRHAHSGHGQ 2089

Query: 325  GHKPGCEKPGNEARGSGESGIQNSETSPGM 354
              + G    G   RGSG S   +SE   G+
Sbjct: 2090 STQRGSRTAGR--RGSGHSESSDSEVHSGV 2117



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 83/338 (24%), Positives = 113/338 (33%), Gaps = 71/338 (21%)

Query: 72   GQGTREAVGTGVRQVPGFGAADALGNRVGEAA----HALGNTGHEIGRQ---AEDVIRHG 124
            GQ T+    T  RQ   F  +DA  + V        H+   T  + G Q   +E  +   
Sbjct: 1330 GQSTQTGSRTSGRQ--RFSHSDATDSEVHSGVSHRPHSQEQTHSQAGSQHGESESTVHER 1387

Query: 125  ADAVRGSWQGVPGHNGAWETSGGHGIFGSQGG--LGGQGQGNP---------GGLGTPW- 172
             +   G      GH  +     GHG    +G    G +G G+          GG   P  
Sbjct: 1388 HETTYGQTGEATGHGHS-----GHGQSTQRGSRTTGRRGSGHSESSDSEVHSGGSHRPQS 1442

Query: 173  ---VHGYPGNSAGSFGMNPQGAPWGQGGNGGPP------NFGTNTQGAVAQPGYGSVRAS 223
                HG  G+  G  G    G      G  G        + G +TQ   +  G    R S
Sbjct: 1443 QEQTHGQAGSQHGESGSTVHGRHGTTHGQTGDTTRHAHYHHGKSTQRGSSTTGR---RGS 1499

Query: 224  NQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGS--------------GSNGDNNNGSSS 269
              +E   +   SG   GS    G +  QSGS                 G  GD    S S
Sbjct: 1500 GHSESSDSEVHSG---GSHTHSGHTHGQSGSQHGESESIIHDRHRITHGQTGDTTRHSYS 1556

Query: 270  G---GSSSGSSSGG---SSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSS-------GN 316
            G    + +GS + G   +S   S  S  +SGGS      E ++G +              
Sbjct: 1557 GHEQTTQTGSRTTGRQRTSHSESTDSEVHSGGSHRPHSREHTYGQAGSQHEEPEFTVHER 1616

Query: 317  HGGSGGGNGHKPGCEKPG---NEARGSGESGIQNSETS 351
            HG + G  G   G    G   +  RGS  +G Q S  S
Sbjct: 1617 HGTTHGQIGDTTGHSHSGHGQSTQRGSRTTGRQRSSHS 1654



 Score = 33.5 bits (75), Expect = 0.33
 Identities = 57/241 (23%), Positives = 82/241 (34%), Gaps = 36/241 (14%)

Query: 133 QGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFG-MNPQGA 191
           +  PGH   +  S       S+G   G   G+  G      HG      G  G ++  G 
Sbjct: 120 EDTPGHKSGYRHSSW-----SEGEEHGYSSGHSRGT-VKCRHGSNSRRLGRQGNLSSSGN 173

Query: 192 PWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQ 251
             G        + G +  G   + G  SV    +    ++  PS   G    SG GS S 
Sbjct: 174 QEGSQKRYHRSSCGHSWSGGKDRHGSSSVEL-RERINKSHISPSRESGEEYESGSGSNSW 232

Query: 252 SGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSES---SWGS 308
                       + G S G  +SG  S  +         G+S    GDSG  S    + +
Sbjct: 233 ERKG--------HGGLSCGLETSGHESNSTQSRIREQKLGSSCSGSGDSGRRSHACGYSN 284

Query: 309 STG--------SSSGNHGGSGGGNGH---KPGCEKPGNEARGSG------ESGIQNSETS 351
           S+G        SS  +H   G GN     + GC+      +G G       SG    E++
Sbjct: 285 SSGCGRPQNASSSCQSHRFGGQGNQFSYIQSGCQSGIKGGQGHGCVSGGQPSGCGQPESN 344

Query: 352 P 352
           P
Sbjct: 345 P 345


>gi|119395750 keratin 1 [Homo sapiens]
          Length = 644

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 50/114 (43%), Positives = 54/114 (47%), Gaps = 2/114 (1%)

Query: 237 SGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGS--SGNSG 294
           SGGGS   GGG     GSS     G   +G   GG      SGGSS GS GGS  SG  G
Sbjct: 513 SGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGG 572

Query: 295 GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNS 348
           G  G  GS SS G   G S G  GGS GG G   G        RGS   G+++S
Sbjct: 573 GGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSS 626



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 49/112 (43%), Positives = 54/112 (48%), Gaps = 2/112 (1%)

Query: 216 GYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSG 275
           GYGS  +S  + G +    SG GGG      GSG  S  SG GS G    G   G   SG
Sbjct: 524 GYGSGGSSYGSGGGSYG--SGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSG 581

Query: 276 SSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHK 327
           SSSGG  GGS GG  G+SGG     GS        GSSSG    SGG +  K
Sbjct: 582 SSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVK 633



 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 55/136 (40%), Positives = 66/136 (48%), Gaps = 20/136 (14%)

Query: 175 GYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPP 234
           G  G   G +G    G+ +G GG     ++G+   G   +  YGS  +S           
Sbjct: 516 GSRGGGGGGYGSG--GSSYGSGGG----SYGSGGGGGGGRGSYGSGGSSY---------- 559

Query: 235 SGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG 294
            GSGGGS  SGGG G   GS GSGS+     G S GG    S   GS GGSSGGS G  G
Sbjct: 560 -GSGGGSYGSGGGGGGH-GSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRG 617

Query: 295 GSRGDSGSESSWGSST 310
            S G  G +SS GSS+
Sbjct: 618 SSSG--GVKSSGGSSS 631



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 47/117 (40%), Positives = 55/117 (47%), Gaps = 7/117 (5%)

Query: 239 GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG 298
           G  S   G        S S S+   + G S GG   G  SGGSS GS GGS G+ GG  G
Sbjct: 488 GEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGG 547

Query: 299 DSGSESSWGSSTGSSSGNHGGSGGGNGH-------KPGCEKPGNEARGSGESGIQNS 348
             GS  S GSS GS  G++G  GGG GH         G  + G+   G G SG + S
Sbjct: 548 GRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGS 604



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 58/147 (39%), Positives = 67/147 (45%), Gaps = 33/147 (22%)

Query: 134 GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPW 193
           G  G  G    SGG   +GS GG  G G G  GG G+   +G  G+S GS      G  +
Sbjct: 516 GSRGGGGGGYGSGGSS-YGSGGGSYGSGGGGGGGRGS---YGSGGSSYGS-----GGGSY 566

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG 253
           G GG GG               G+GS  + + + G       GSGGG   S GG GS  G
Sbjct: 567 GSGGGGG---------------GHGSYGSGSSSGGYRG----GSGGGGGGSSGGRGSGGG 607

Query: 254 SSGSGSNGDNNNGSSSGG--SSSGSSS 278
           SSG    G    GSSSGG  SS GSSS
Sbjct: 608 SSGGSIGG---RGSSSGGVKSSGGSSS 631



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 42/122 (34%), Positives = 53/122 (43%), Gaps = 5/122 (4%)

Query: 236 GSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGG 295
           G GGGS  +GGG GS+S  +  GS   + + +  GG  SG   G   GG  GG  G  G 
Sbjct: 50  GGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGF 109

Query: 296 SRGDSGSESSWGSSTGS---SSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ--NSET 350
             G  G     G  +G      G  GG G G G+ P C   G +     +S +Q  N E 
Sbjct: 110 GGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEI 169

Query: 351 SP 352
            P
Sbjct: 170 DP 171



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 49/170 (28%), Positives = 57/170 (33%), Gaps = 7/170 (4%)

Query: 205 GTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNN 264
           G  + G  +    G +    +    +     G GG  S+ GGG GS     G GS    N
Sbjct: 10  GYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVN 69

Query: 265 NGSSSG-------GSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNH 317
            G S         G   GS  GG  GG   G  G  GG  G  G         GS  G  
Sbjct: 70  LGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGGGGF 129

Query: 318 GGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSK 367
           GG G G G   G   P     G  E  I  S   P     D   +  KS+
Sbjct: 130 GGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSR 179



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 41/116 (35%), Positives = 46/116 (39%), Gaps = 12/116 (10%)

Query: 241 SSNSG--GGSGSQSGSSGSGSNGDNNNGSS---SGGSSSGSSSGGSSGGSSGGSSG---- 291
           SS SG   G G  SGS+G  +       SS   SGG     SS G  GGS G   G    
Sbjct: 6   SSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSR 65

Query: 292 ---NSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESG 344
              N GGS+  S S +  G       G +GG G G G   G    G    G G  G
Sbjct: 66  SLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGG 121



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 29/89 (32%), Positives = 38/89 (42%), Gaps = 2/89 (2%)

Query: 265 NGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGN 324
           N S S  +S  + SGG S G  GG  G+ G S G  G   S+GS  G   G      GG+
Sbjct: 500 NVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGG--SYGSGGGGGGGRGSYGSGGS 557

Query: 325 GHKPGCEKPGNEARGSGESGIQNSETSPG 353
            +  G    G+   G G     +  +S G
Sbjct: 558 SYGSGGGSYGSGGGGGGHGSYGSGSSSGG 586



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 37/113 (32%), Positives = 44/113 (38%), Gaps = 21/113 (18%)

Query: 146 GGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGS-FGMNPQGAPWGQGGNGGPPNF 204
           GG G FG+ GG G +   N GG  +  +    G   GS FG    G  +G GG GG    
Sbjct: 51  GGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGG---- 106

Query: 205 GTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGG-GSGSQSGSSG 256
           G    G +   G+G                 GSGGG    GG G G   G  G
Sbjct: 107 GGFGGGGIGGGGFGGF---------------GSGGGGFGGGGFGGGGYGGGYG 144



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 30/95 (31%), Positives = 33/95 (34%), Gaps = 1/95 (1%)

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGG-SGSQS 252
           G GG       G  ++  V   G  S+  S    G       G  GG    GGG  G   
Sbjct: 50  GGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGF 109

Query: 253 GSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSG 287
           G  G G  G    GS  GG   G   GG  GG  G
Sbjct: 110 GGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYG 144



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 7/137 (5%)

Query: 65  SKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHG 124
           S++S         +V T    + G G+    G   G    + G+ G   G         G
Sbjct: 491 SRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRG 550

Query: 125 ADAVRGSWQGVPGHN-GAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGS 183
           +    GS  G  G + G+    GGHG +GS    GG  +G  GG G     G      GS
Sbjct: 551 SYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGY-RGGSGGGG-----GGSSGGRGS 604

Query: 184 FGMNPQGAPWGQGGNGG 200
            G +  G+  G+G + G
Sbjct: 605 GGGSSGGSIGGRGSSSG 621



 Score = 35.4 bits (80), Expect = 0.088
 Identities = 40/150 (26%), Positives = 55/150 (36%), Gaps = 22/150 (14%)

Query: 18  SGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTRE 77
           SGE  P  S   ST        G   G     G G   G   G   GS  S   G G R 
Sbjct: 494 SGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSG---GSSYGSGGGSYGSGGGGGGGRG 550

Query: 78  AVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPG 137
           + G+G             G+  G    + G+ G   G  +     +G+ +  G ++G  G
Sbjct: 551 SYGSG-------------GSSYGSGGGSYGSGGGGGGHGS-----YGSGSSSGGYRGGSG 592

Query: 138 HNGAWETSG-GHGIFGSQGGLGGQGQGNPG 166
             G   + G G G   S G +GG+G  + G
Sbjct: 593 GGGGGSSGGRGSGGGSSGGSIGGRGSSSGG 622



 Score = 30.8 bits (68), Expect = 2.2
 Identities = 36/134 (26%), Positives = 46/134 (34%), Gaps = 7/134 (5%)

Query: 40  GHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNR- 98
           G+  G   S G    I  +    + S      G G   + G G      FGA    G+R 
Sbjct: 10  GYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGS---FGAGGGFGSRS 66

Query: 99  ---VGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQG 155
              +G +     +     GR +     +G     G   G  G  G     GG G FGS G
Sbjct: 67  LVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGG 126

Query: 156 GLGGQGQGNPGGLG 169
           G  G G    GG G
Sbjct: 127 GGFGGGGFGGGGYG 140



 Score = 30.8 bits (68), Expect = 2.2
 Identities = 40/147 (27%), Positives = 52/147 (35%), Gaps = 22/147 (14%)

Query: 56  GKEAGGAAG--SKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEI 113
           G  + G+AG  +         TR + G G R     G   + G   G  + +L N G   
Sbjct: 15  GGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSK 74

Query: 114 GRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWV 173
                     G  +  G   G  G  G     GG G     GG+GG G G          
Sbjct: 75  SISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFG----GGGIGGGGFG---------- 120

Query: 174 HGYPGNSAGSFGMNPQGAPWGQGGNGG 200
            G+ G+  G FG    G  +G GG GG
Sbjct: 121 -GF-GSGGGGFG----GGGFGGGGYGG 141


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 88/311 (28%), Positives = 107/311 (34%), Gaps = 46/311 (14%)

Query: 82  GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGA 141
           G++ +PG G       + GE     G+ G      A        DA     +G PG  GA
Sbjct: 639 GLQGLPGTGGPPGENGKPGEPGPK-GDAG------APGAPGGKGDAGAPGERGPPGLAGA 691

Query: 142 WETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAGSFGMNPQG---APWGQGG 197
               GG G  G +GG G  G  G PG  GTP + G PG   G     P+G    P G G 
Sbjct: 692 PGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGA 751

Query: 198 NGGPPNFGTNTQ-------------------GAVAQPGYGSVRASNQNEGCTNPP-PSGS 237
           +G P   G                       GA   PG    R S    G T PP P+G 
Sbjct: 752 DGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPRGSPGERGETGPPGPAGF 811

Query: 238 GGGSSNSG--GGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSG--------GSSGGSSG 287
            G    +G  GG G +      G  G        GGS      G        GS GG   
Sbjct: 812 PGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGA 871

Query: 288 GSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH-----KPGCEKPGNEARGSGE 342
                + G  G  GS  + G    S S    G  G  G+      PG   P  +A   GE
Sbjct: 872 AGFPGARGLPGPPGSNGNPGPPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGE 931

Query: 343 SGIQNSETSPG 353
            G   ++  PG
Sbjct: 932 KGSPGAQGPPG 942



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 95/346 (27%), Positives = 116/346 (33%), Gaps = 27/346 (7%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTR 76
           G+  A  L+ G    G N  +      G+    G+    G +          E    G  
Sbjct: 420 GANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLP 479

Query: 77  EAVGTGVRQVPGFGAADALGNRVGEAAHA--LGNTGHEIGRQAEDVIRHGADAVRGS--W 132
            A G   R  PGF          GE   A   G  G    R A      G D V G    
Sbjct: 480 GAAGE--RGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAG--EPGRDGVPGGPGM 535

Query: 133 QGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGG-LGTPWVHGYPGNSAGSFGMNPQGA 191
           +G+PG  G   + G  G  GSQG  G  G   P G  G P V G+PG           G 
Sbjct: 536 RGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGE 595

Query: 192 PWGQGGNG--GPP--NFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGG 247
             G GG G  GPP  N  T  QG     G G       ++G T PP      G   +GG 
Sbjct: 596 RGGPGGPGPQGPPGKNGETGPQGPPGPTGPGG------DKGDTGPPGPQGLQGLPGTGGP 649

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWG 307
            G        G  GD     + GG     + G        G+ G  GG+ G  G E   G
Sbjct: 650 PGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGA-GPPGPEG--G 706

Query: 308 SSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
                  G  G +G      PG +    E  G G  G +  +  PG
Sbjct: 707 KGAAGPPGPPGAAG-----TPGLQGMPGERGGLGSPGPKGDKGEPG 747



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 86/316 (27%), Positives = 109/316 (34%), Gaps = 32/316 (10%)

Query: 61  GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120
           G  G   +     G  +A   G R  PG   A  L    G         G E G+ A   
Sbjct: 660 GPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPP-------GPEGGKGAAGP 712

Query: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQG-------QGNPGGLGTPWV 173
                 A     QG+PG  G   + G  G  G  GG G  G       +G  G +G P  
Sbjct: 713 PGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGP 772

Query: 174 HGYPGNSA--GSFGM----NPQGAPWGQGGNGGPPNFG--TNTQGAVAQPGYGSVRASNQ 225
            G PG+    G+ G+     P+G+P G+ G  GPP         G   +PG    R +  
Sbjct: 773 AGQPGDKGEGGAPGLPGIAGPRGSP-GERGETGPPGPAGFPGAPGQNGEPGGKGERGAPG 831

Query: 226 NEGCTNPP-----PSGSG-GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSG 279
            +G   PP     P GSG  G     G  G +    G G+ G        G   S  + G
Sbjct: 832 EKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPG 891

Query: 280 GSSGGSSGGSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEA 337
                 S G  G  G  G+ G  GS    G    +      GS G  G  PG   P   A
Sbjct: 892 PPGPSGSPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQG-PPGAPGPLGIA 950

Query: 338 RGSGESGIQNSETSPG 353
             +G  G+      PG
Sbjct: 951 GITGARGLAGPPGMPG 966



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 73/294 (24%), Positives = 100/294 (34%), Gaps = 34/294 (11%)

Query: 82  GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVI--RHGADAVRGSWQGVPGHN 139
           G+   PG         R GE     G TG   G + E+ +   +GA    G  +G PG  
Sbjct: 255 GIPGFPGMKGHRGFDGRNGEK----GETGAP-GLKGENGLPGENGAPGPMGP-RGAPGER 308

Query: 140 GAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNG 199
           G     G  G  G+ G  G  GQ  PG  G P   G+PG+      + P G+P   G  G
Sbjct: 309 GRPGLPGAAGARGNDGARGSDGQ--PGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPG 366

Query: 200 -----------------GPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSS 242
                            GPP     + G   + G   +  +    G   PP      G+ 
Sbjct: 367 QRGEPGPQGHAGAQGPPGPPGIN-GSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAP 425

Query: 243 NSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDS 300
              GG+G    +   G  G       +G      + G      S G  G +G  G+ G+ 
Sbjct: 426 GLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGER 485

Query: 301 GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGM 354
           G+    G +  +      G  G  G  PG   P      +GE G       PGM
Sbjct: 486 GAPGFRGPAGPNGIPGEKGPAGERG-APG---PAGPRGAAGEPGRDGVPGGPGM 535



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 70/229 (30%), Positives = 90/229 (39%), Gaps = 15/229 (6%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAGSFGM-NPQGA 191
            G PG  G     G  G  G +G  G QG  G PG LG   + G  G  AG  GM  P+G+
Sbjct: 912  GAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARG-LAGPPGMPGPRGS 970

Query: 192  PWGQG--GNGGPP--NFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGG 247
            P  QG  G  G P  N  +  +G     G   +  +    G    P S    G   S GG
Sbjct: 971  PGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGG 1030

Query: 248  SGSQSGSSGSGSNGDNNNGSSSG--GSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESS 305
             G +  +   G+ G   +    G  G +  S   G SG +    +    GSRG  G +  
Sbjct: 1031 KGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGP 1090

Query: 306  WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGS-GESGIQNSETSPG 353
             G           G+ G  GH+     PG  A GS G +G Q +  SPG
Sbjct: 1091 RGD---KGETGERGAAGIKGHRGFPGNPG--APGSPGPAGQQGAIGSPG 1134



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 66/240 (27%), Positives = 84/240 (35%), Gaps = 21/240 (8%)

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAGSFGMNPQG 190
           +QG PG  G    SG  G  G+ G  G  G+ G  G  G P   G PG   G  G  P G
Sbjct: 199 YQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPGERGLPG-PPGIKG--PAG 255

Query: 191 APWGQGGNGGPPNFGTNTQ-GAVAQPGYGSVRASNQNEGCTNPP-PSGSGGGSSNSG--G 246
            P   G  G     G N + G    PG           G   P  P G+ G     G  G
Sbjct: 256 IPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPG 315

Query: 247 GSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSES 304
            +G++      GS+G        G +    S G        GS G++G  G RG+ G + 
Sbjct: 316 AAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQG 375

Query: 305 SWGSSTGSSSGNHGGSGGGNGHK-----------PGCEKPGNEARGSGESGIQNSETSPG 353
             G+          GS GG G              G   P   A  +G  G++     PG
Sbjct: 376 HAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPG 435



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 105/390 (26%), Positives = 134/390 (34%), Gaps = 71/390 (18%)

Query: 17   GSGEAGPLQSGEEST-GTNIGEALGHGLGDALSEGVGKAIGKEAG--GAAGSKVSEALGQ 73
            G G+AG    GE    G      L  G G    EG GK      G  GAAG+   + +  
Sbjct: 673  GKGDAGA--PGERGPPGLAGAPGLRGGAGPPGPEG-GKGAAGPPGPPGAAGTPGLQGM-P 728

Query: 74   GTREAVGT----GVRQVPGFGAADALGNRVGEAAHA--LGNTGHEIGRQAEDVIRHGADA 127
            G R  +G+    G +  PG   AD +  + G       +G  G     Q  D    GA  
Sbjct: 729  GERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGP--AGQPGDKGEGGAPG 786

Query: 128  VRG--SWQGVPGHNGAWETSGGHGIFGS---QGGLGGQGQ----GNPGGLGTPWVHGYPG 178
            + G    +G PG  G     G  G  G+    G  GG+G+    G  G  G P V G PG
Sbjct: 787  LPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPG 846

Query: 179  NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPP-PSGS 237
             S  +    PQG    +G  GGP        GA   PG   +     + G   PP PSGS
Sbjct: 847  GSGPAGPPGPQGVKGERGSPGGP--------GAAGFPGARGLPGPPGSNGNPGPPGPSGS 898

Query: 238  GG-----------------------GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSS 274
             G                       G +   G  GS       G+ G       +G    
Sbjct: 899  PGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGL 958

Query: 275  GSSSG-----GSSG-----GSSGGSSGNS-GGSRGDSGSESSWGSSTGSSSGNHGGSGGG 323
                G     GS G     G SG    N   G RG  G +   G +  +      G+ G 
Sbjct: 959  AGPPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGS 1018

Query: 324  NGHKPGCEKPGNEARGSGESGIQNSETSPG 353
            +G       PG    G G+ G   S  +PG
Sbjct: 1019 DGLPGRDGSPG----GKGDRGENGSPGAPG 1044



 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 69/225 (30%), Positives = 80/225 (35%), Gaps = 25/225 (11%)

Query: 124  GADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHGYPGN 179
            G   V+G   G PG NG     G  G  G  G  G  G+    GNPG  G P   G PG 
Sbjct: 972  GPQGVKGE-SGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGG 1030

Query: 180  SAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPP-PSGSG 238
                      GAP G  G+ GPP       G V   G    R  +   G    P P+GS 
Sbjct: 1031 KGDRGENGSPGAP-GAPGHPGPP-------GPVGPAGKSGDRGESGPAGPAGAPGPAGSR 1082

Query: 239  GGSSNSG-----GGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG-SSGGSSG--GSS 290
            G     G     G +G +  +   G  G   N  + G        G   S G +G  G  
Sbjct: 1083 GAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPV 1142

Query: 291  GNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKP 333
            G SG  G  G SG     G      +    GS G  GH PG   P
Sbjct: 1143 GPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGH-PGQPGP 1186



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 64/238 (26%), Positives = 81/238 (34%), Gaps = 22/238 (9%)

Query: 134 GVPGHNGAWETSGGHGIFGS---QGGLGGQGQGNPGG-LGTPWVHGYPGNSAGSFGMNPQ 189
           G PG  G   TSG  G  GS   QG  G  GQ  P G  G P   G P   AG  G + +
Sbjct: 177 GPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIG-PSGPAGKDGESGR 235

Query: 190 GAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVR------ASNQNEGCTNPPPSGSGGGSSN 243
               G+ G  GPP      +G    PG+  ++        N  +G T  P      G   
Sbjct: 236 PGRPGERGLPGPPGI----KGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPG 291

Query: 244 SGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSG 301
             G  G        G  G      ++G   +  + G        G  G +G  GS G  G
Sbjct: 292 ENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKG 351

Query: 302 SESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPG-----NEARGSGESGIQNSETSPGM 354
                GS   + +    G  G  GH      PG         G GE G      +PG+
Sbjct: 352 EVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGL 409



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 63/230 (27%), Positives = 80/230 (34%), Gaps = 31/230 (13%)

Query: 124  GADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGS 183
            GA+ + G  +G PG  G    +G  G  G  G  G  G   PG  G+P   G  G +   
Sbjct: 984  GANGLSGE-RGPPGPQGLPGLAGTAGEPGRDGNPGSDGL--PGRDGSPGGKGDRGENGS- 1039

Query: 184  FGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSN 243
                  GAP G  G+ GPP       G V   G    R  +         P+G  G    
Sbjct: 1040 -----PGAP-GAPGHPGPP-------GPVGPAGKSGDRGES--------GPAGPAG---- 1074

Query: 244  SGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSE 303
            + G +GS+      G  GD       G +      G      + GS G   G +G  GS 
Sbjct: 1075 APGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPG-PAGQQGAIGSP 1133

Query: 304  SSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
               G           G  G +GH PG   P       GE G + S   PG
Sbjct: 1134 GPAGPRGPVGPSGPPGKDGTSGH-PGPIGPPGPRGNRGERGSEGSPGHPG 1182



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 53/201 (26%), Positives = 67/201 (33%), Gaps = 12/201 (5%)

Query: 161 GQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSV 220
           GQG  G  G P   G PG +         G+P   G  G   +  T  Q    Q     V
Sbjct: 101 GQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDV 160

Query: 221 RASNQNEGCTN-PPPSGSGG--GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSS 277
           ++     G    P P+G  G  G   + G  GS       G  G+      SG      +
Sbjct: 161 KSGVAVGGLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGA 220

Query: 278 SGGSSGGSSGGSSGNSG-----GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEK 332
            G S      G SG  G     G  G  G +   G         H G  G NG K     
Sbjct: 221 IGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGA 280

Query: 333 PGNEARGSGESGIQNSETSPG 353
           PG +    GE+G+     +PG
Sbjct: 281 PGLK----GENGLPGENGAPG 297



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 48/175 (27%), Positives = 60/175 (34%), Gaps = 22/175 (12%)

Query: 124  GADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAG 182
            G    RG   G  G  GA   +G  G  G QG  G +G+ G  G  G     G+PGN   
Sbjct: 1059 GKSGDRGE-SGPAGPAGAPGPAGSRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNP-- 1115

Query: 183  SFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSS 242
                   GAP    G+ GP       QGA+  PG    R      G + PP      G  
Sbjct: 1116 -------GAP----GSPGP----AGQQGAIGSPGPAGPRGP---VGPSGPPGKDGTSGHP 1157

Query: 243  NSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSR 297
               G  G +      GS G   +    G      + G   GG    +    GG +
Sbjct: 1158 GPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAGIGGEK 1212



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 58/240 (24%), Positives = 75/240 (31%), Gaps = 32/240 (13%)

Query: 137 GHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAGSFGMNPQ------ 189
           G  G     G  GI G  G  G  GQ G+PG  G P +        G    +PQ      
Sbjct: 103 GPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGI--CESCPTGPQNYSPQYDSYDV 160

Query: 190 ------GAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSN 243
                 G   G  G  GPP       G    PG      S  + G   PP      G S 
Sbjct: 161 KSGVAVGGLAGYPGPAGPP-------GPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSG 213

Query: 244 SGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--------G 295
             G  G+   S  +G +G++      G        G        G  G  G        G
Sbjct: 214 PPGPPGAIGPSGPAGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNG 273

Query: 296 SRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPG--NEARGSGESGIQNSETSPG 353
            +G++G+    G +         G  G  G      +PG    A   G  G + S+  PG
Sbjct: 274 EKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSDGQPG 333



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 38/141 (26%), Positives = 49/141 (34%), Gaps = 23/141 (16%)

Query: 124  GADAVRGSWQGVPGHNGAWETSGGHGI---FGSQGGLGGQGQGNPGGLGTPWVHGYPGNS 180
            G    RG+  G+ GH G     G  G     G QG +G  G   P G   P   G PG  
Sbjct: 1095 GETGERGA-AGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGP--SGPPGKD 1151

Query: 181  AGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG 240
              S    P G P  +G  G         +G+   PG+          G   PP      G
Sbjct: 1152 GTSGHPGPIGPPGPRGNRG--------ERGSEGSPGH---------PGQPGPPGPPGAPG 1194

Query: 241  SSNSGGGSGSQSGSSGSGSNG 261
                G G+ + +G  G  + G
Sbjct: 1195 PCCGGVGAAAIAGIGGEKAGG 1215



 Score = 36.2 bits (82), Expect = 0.051
 Identities = 26/79 (32%), Positives = 32/79 (40%), Gaps = 10/79 (12%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ-------GNPGGLGTPWVHGYPGNSAGSFGM 186
            G PG +G   TSG  G  G  G  G +G+       G+PG  G P   G PG   G  G 
Sbjct: 1146 GPPGKDG---TSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGVGA 1202

Query: 187  NPQGAPWGQGGNGGPPNFG 205
                   G+   G  P +G
Sbjct: 1203 AAIAGIGGEKAGGFAPYYG 1221


>gi|4507353 TBP-associated factor 15 isoform 2 [Homo sapiens]
          Length = 589

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 68/216 (31%), Positives = 80/216 (37%), Gaps = 26/216 (12%)

Query: 118 EDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYP 177
           ED    G D     + G  G+ G     GG G  G +GG GG   G   G       GY 
Sbjct: 382 EDSRPSGGDFRGRGYGGERGYRGR----GGRG--GDRGGYGGDRSGGGYGGDRSSGGGYS 435

Query: 178 GN-SAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSG 236
           G+ S G +G +  G  +G    GG   +G +  G     GYG  R               
Sbjct: 436 GDRSGGGYGGDRSGGGYGGDRGGG---YGGDRGG-----GYGGDRGGGYG--------GD 479

Query: 237 SGGGSSNSGGGSGSQSGSSGS---GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS 293
            GG   + GGG G   G  G    G  GD        G   G  S G  GG  GG SG  
Sbjct: 480 RGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYG 539

Query: 294 GGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPG 329
           G   G  G + S G   G   G +GG  GG G K G
Sbjct: 540 GDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMG 575



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 54/168 (32%), Positives = 65/168 (38%), Gaps = 16/168 (9%)

Query: 194 GQGGNGGPPN-FGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS 252
           G+GG GG    +G +  G     GYG  R+S    G  +   SG G G   SGGG G   
Sbjct: 404 GRGGRGGDRGGYGGDRSGG----GYGGDRSSG---GGYSGDRSGGGYGGDRSGGGYGGDR 456

Query: 253 GSSGSGSNGDNNNGSSSGGSSSGSSS-GGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG 311
           G    G  G    G   GG        GG  GG  GG  G  GG RG       +G   G
Sbjct: 457 GGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRG------GYGGDRG 510

Query: 312 SSSGNHGGSGGGNGHKP-GCEKPGNEARGSGESGIQNSETSPGMFNFD 358
              G+ GG GG       G ++ G    G   SG    + S G +  D
Sbjct: 511 GYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGD 558



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 58/188 (30%), Positives = 73/188 (38%), Gaps = 15/188 (7%)

Query: 122 RHGADAVRGSWQGVP---GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPG 178
           R G    RG + G     G+ G   + GG+    S GG GG   G  GG G     GY G
Sbjct: 405 RGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSG--GGYGGDRGGGYGG 462

Query: 179 NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSG 238
           +  G +G +  G   G GG+ G   +G +  G     GYG  R     +        G  
Sbjct: 463 DRGGGYGGDRGG---GYGGDRG--GYGGDRGG-----GYGGDRGGYGGDRGGYGGDRGGY 512

Query: 239 GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG 298
           GG     GG  S+ G  G    G    G  SGG     S GG  G   GG  G+ GG  G
Sbjct: 513 GGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGG 572

Query: 299 DSGSESSW 306
             G  + +
Sbjct: 573 KMGGRNDY 580



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 55/194 (28%), Positives = 69/194 (35%), Gaps = 32/194 (16%)

Query: 178 GNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE--GCTNPPPS 235
           G+  G  G        G  G GG P  G         P  G++  + +N    C  P P 
Sbjct: 326 GSGGGRRGRGGYRGRGGFQGRGGDPKSG---DWVCPNPSCGNMNFARRNSCNQCNEPRPE 382

Query: 236 ---------------------GSGGGSSNSGGGSGSQSGSS--GSGSNGDNNNGSSSGGS 272
                                G GG   + GG  G +SG    G  S+G   +G  SGG 
Sbjct: 383 DSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGG 442

Query: 273 SSGSSSGGSSGGSSGGSSG--NSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGC 330
             G  SGG  GG  GG  G    GG  GD G    +G   G   G+ GG  GG+    G 
Sbjct: 443 YGGDRSGGGYGGDRGGGYGGDRGGGYGGDRG--GGYGGDRGGYGGDRGGGYGGDRGGYGG 500

Query: 331 EKPGNEARGSGESG 344
           ++ G      G  G
Sbjct: 501 DRGGYGGDRGGYGG 514



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 59/215 (27%), Positives = 79/215 (36%), Gaps = 45/215 (20%)

Query: 152 GSQGGLGGQGQ-----GNPGGLG----TPWVHGYPGNSAGSFGMNPQG-APWGQGGNGGP 201
           GS G  GG+ Q     GNPG  G    +    GY   +  S+G N  G + +GQ  +   
Sbjct: 5   GSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSYSQSY 64

Query: 202 PNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG--------------SSNSGGG 247
             +    Q + +Q  Y     +NQ +   N   SGS GG              S +   G
Sbjct: 65  GGYENQKQSSYSQQPY-----NNQGQQ-QNMESSGSQGGRAPSYDQPDYGQQDSYDQQSG 118

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSS--------------GGSSGGSSGNS 293
                GS    SN D  + S S    S  S   +               G  + G  G+ 
Sbjct: 119 YDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQ 178

Query: 294 GGSRGDSGSESSW-GSSTGSSSGNHGGSGGGNGHK 327
           GG RG  G +    G  TGSS G+ GG     GH+
Sbjct: 179 GGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHR 213



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 54/178 (30%), Positives = 69/178 (38%), Gaps = 14/178 (7%)

Query: 36  GEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFG---AA 92
           G+  G G G   S G G +  +  GG  G +     G G     G G  +  G+G     
Sbjct: 417 GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDR--SGGGYGGDRGGGYGGDRGGGYGGDRGG 474

Query: 93  DALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFG 152
              G+R G      G  G + G    D   +G D  RG + G  G  G   + GG+G  G
Sbjct: 475 GYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGD--RGGYGGDRGGYGGDRSRGGYG--G 530

Query: 153 SQGGLGGQGQGNPGGLGTPWV-HGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQ 209
            +GG  G G    GG G      GY G+  G +G    G   G GG  G  N   N Q
Sbjct: 531 DRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYG----GDRGGYGGKMGGRNDYRNDQ 584



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 47/154 (30%), Positives = 51/154 (33%), Gaps = 42/154 (27%)

Query: 230 TNPPPSGSGGGSSNSGGGSGSQSGSSG-SGSNGDNNNGS--------------------- 267
           T  P    GGGS     G G   G  G  G  GD  +G                      
Sbjct: 316 TRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQ 375

Query: 268 ----------SSGGSSSGSSSGGSSG----GSSGGSSGNSGGSR---GDSGSESSWGSST 310
                      SGG   G   GG  G    G  GG  G  GG R   G  G  SS G  +
Sbjct: 376 CNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYS 435

Query: 311 GS-SSGNHGG--SGGGNGHKPGCEKPGNEARGSG 341
           G  S G +GG  SGGG G   G    G+   G G
Sbjct: 436 GDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYG 469



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 24/65 (36%), Positives = 27/65 (41%), Gaps = 7/65 (10%)

Query: 240 GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGD 299
           G  N G G GSQ G  G G    +  G  +G      SSGG  GG          G R D
Sbjct: 168 GEDNRGYG-GSQGGGRGRGGYDKDGRGPMTG------SSGGDRGGFKNFGGHRDYGPRTD 220

Query: 300 SGSES 304
           + SES
Sbjct: 221 ADSES 225


>gi|21327701 TBP-associated factor 15 isoform 1 [Homo sapiens]
          Length = 592

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 68/216 (31%), Positives = 80/216 (37%), Gaps = 26/216 (12%)

Query: 118 EDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYP 177
           ED    G D     + G  G+ G     GG G  G +GG GG   G   G       GY 
Sbjct: 385 EDSRPSGGDFRGRGYGGERGYRGR----GGRG--GDRGGYGGDRSGGGYGGDRSSGGGYS 438

Query: 178 GN-SAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSG 236
           G+ S G +G +  G  +G    GG   +G +  G     GYG  R               
Sbjct: 439 GDRSGGGYGGDRSGGGYGGDRGGG---YGGDRGG-----GYGGDRGGGYG--------GD 482

Query: 237 SGGGSSNSGGGSGSQSGSSGS---GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS 293
            GG   + GGG G   G  G    G  GD        G   G  S G  GG  GG SG  
Sbjct: 483 RGGYGGDRGGGYGGDRGGYGGDRGGYGGDRGGYGGDRGGYGGDRSRGGYGGDRGGGSGYG 542

Query: 294 GGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPG 329
           G   G  G + S G   G   G +GG  GG G K G
Sbjct: 543 GDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGGKMG 578



 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 54/168 (32%), Positives = 65/168 (38%), Gaps = 16/168 (9%)

Query: 194 GQGGNGGPPN-FGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS 252
           G+GG GG    +G +  G     GYG  R+S    G  +   SG G G   SGGG G   
Sbjct: 407 GRGGRGGDRGGYGGDRSGG----GYGGDRSSG---GGYSGDRSGGGYGGDRSGGGYGGDR 459

Query: 253 GSSGSGSNGDNNNGSSSGGSSSGSSS-GGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTG 311
           G    G  G    G   GG        GG  GG  GG  G  GG RG       +G   G
Sbjct: 460 GGGYGGDRGGGYGGDRGGGYGGDRGGYGGDRGGGYGGDRGGYGGDRG------GYGGDRG 513

Query: 312 SSSGNHGGSGGGNGHKP-GCEKPGNEARGSGESGIQNSETSPGMFNFD 358
              G+ GG GG       G ++ G    G   SG    + S G +  D
Sbjct: 514 GYGGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGD 561



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 58/188 (30%), Positives = 73/188 (38%), Gaps = 15/188 (7%)

Query: 122 RHGADAVRGSWQGVP---GHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPG 178
           R G    RG + G     G+ G   + GG+    S GG GG   G  GG G     GY G
Sbjct: 408 RGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGGYGGDRSG--GGYGGDRGGGYGG 465

Query: 179 NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSG 238
           +  G +G +  G   G GG+ G   +G +  G     GYG  R     +        G  
Sbjct: 466 DRGGGYGGDRGG---GYGGDRG--GYGGDRGG-----GYGGDRGGYGGDRGGYGGDRGGY 515

Query: 239 GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG 298
           GG     GG  S+ G  G    G    G  SGG     S GG  G   GG  G+ GG  G
Sbjct: 516 GGDRGGYGGDRSRGGYGGDRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYGGDRGGYGG 575

Query: 299 DSGSESSW 306
             G  + +
Sbjct: 576 KMGGRNDY 583



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 55/194 (28%), Positives = 69/194 (35%), Gaps = 32/194 (16%)

Query: 178 GNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE--GCTNPPPS 235
           G+  G  G        G  G GG P  G         P  G++  + +N    C  P P 
Sbjct: 329 GSGGGRRGRGGYRGRGGFQGRGGDPKSG---DWVCPNPSCGNMNFARRNSCNQCNEPRPE 385

Query: 236 ---------------------GSGGGSSNSGGGSGSQSGSS--GSGSNGDNNNGSSSGGS 272
                                G GG   + GG  G +SG    G  S+G   +G  SGG 
Sbjct: 386 DSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYSGDRSGGG 445

Query: 273 SSGSSSGGSSGGSSGGSSG--NSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGC 330
             G  SGG  GG  GG  G    GG  GD G    +G   G   G+ GG  GG+    G 
Sbjct: 446 YGGDRSGGGYGGDRGGGYGGDRGGGYGGDRG--GGYGGDRGGYGGDRGGGYGGDRGGYGG 503

Query: 331 EKPGNEARGSGESG 344
           ++ G      G  G
Sbjct: 504 DRGGYGGDRGGYGG 517



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 60/215 (27%), Positives = 79/215 (36%), Gaps = 42/215 (19%)

Query: 152 GSQGGLGGQGQ-----GNPGGLG----TPWVHGYPGNSAGSFGMNPQG-APWGQGGNGGP 201
           GS G  GG+ Q     GNPG  G    +    GY   +  S+G N  G + +GQ  +G  
Sbjct: 5   GSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSGYSSYGQSQSGYS 64

Query: 202 PNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG--------------SSNSGGG 247
            ++G        Q  Y     +NQ +   N   SGS GG              S +   G
Sbjct: 65  QSYGGYENQK--QSSYSQQPYNNQGQQ-QNMESSGSQGGRAPSYDQPDYGQQDSYDQQSG 121

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSS--------------GGSSGGSSGNS 293
                GS    SN D  + S S    S  S   +               G  + G  G+ 
Sbjct: 122 YDQHQGSYDEQSNYDQQHDSYSQNQQSYHSQRENYSHHTQDDRRDVSRYGEDNRGYGGSQ 181

Query: 294 GGSRGDSGSESSW-GSSTGSSSGNHGGSGGGNGHK 327
           GG RG  G +    G  TGSS G+ GG     GH+
Sbjct: 182 GGGRGRGGYDKDGRGPMTGSSGGDRGGFKNFGGHR 216



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 54/178 (30%), Positives = 69/178 (38%), Gaps = 14/178 (7%)

Query: 36  GEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFG---AA 92
           G+  G G G   S G G +  +  GG  G +     G G     G G  +  G+G     
Sbjct: 420 GDRSGGGYGGDRSSGGGYSGDRSGGGYGGDR--SGGGYGGDRGGGYGGDRGGGYGGDRGG 477

Query: 93  DALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFG 152
              G+R G      G  G + G    D   +G D  RG + G  G  G   + GG+G  G
Sbjct: 478 GYGGDRGGYGGDRGGGYGGDRGGYGGDRGGYGGD--RGGYGGDRGGYGGDRSRGGYG--G 533

Query: 153 SQGGLGGQGQGNPGGLGTPWV-HGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQ 209
            +GG  G G    GG G      GY G+  G +G    G   G GG  G  N   N Q
Sbjct: 534 DRGGGSGYGGDRSGGYGGDRSGGGYGGDRGGGYG----GDRGGYGGKMGGRNDYRNDQ 587



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 47/154 (30%), Positives = 51/154 (33%), Gaps = 42/154 (27%)

Query: 230 TNPPPSGSGGGSSNSGGGSGSQSGSSG-SGSNGDNNNGS--------------------- 267
           T  P    GGGS     G G   G  G  G  GD  +G                      
Sbjct: 319 TRRPEFMRGGGSGGGRRGRGGYRGRGGFQGRGGDPKSGDWVCPNPSCGNMNFARRNSCNQ 378

Query: 268 ----------SSGGSSSGSSSGGSSG----GSSGGSSGNSGGSR---GDSGSESSWGSST 310
                      SGG   G   GG  G    G  GG  G  GG R   G  G  SS G  +
Sbjct: 379 CNEPRPEDSRPSGGDFRGRGYGGERGYRGRGGRGGDRGGYGGDRSGGGYGGDRSSGGGYS 438

Query: 311 GS-SSGNHGG--SGGGNGHKPGCEKPGNEARGSG 341
           G  S G +GG  SGGG G   G    G+   G G
Sbjct: 439 GDRSGGGYGGDRSGGGYGGDRGGGYGGDRGGGYG 472



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 24/65 (36%), Positives = 27/65 (41%), Gaps = 7/65 (10%)

Query: 240 GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGD 299
           G  N G G GSQ G  G G    +  G  +G      SSGG  GG          G R D
Sbjct: 171 GEDNRGYG-GSQGGGRGRGGYDKDGRGPMTG------SSGGDRGGFKNFGGHRDYGPRTD 223

Query: 300 SGSES 304
           + SES
Sbjct: 224 ADSES 228



 Score = 32.7 bits (73), Expect = 0.57
 Identities = 35/115 (30%), Positives = 43/115 (37%), Gaps = 9/115 (7%)

Query: 239 GGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG 298
           G   + G G  SQS  SG G   D    SS G + SG SS G S   SG S    G    
Sbjct: 21  GNPGSQGYGQASQS-YSGYGQTTD----SSYGQNYSGYSSYGQS--QSGYSQSYGGYENQ 73

Query: 299 DSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKP--GNEARGSGESGIQNSETS 351
              S S    +      N   SG   G  P  ++P  G +     +SG    + S
Sbjct: 74  KQSSYSQQPYNNQGQQQNMESSGSQGGRAPSYDQPDYGQQDSYDQQSGYDQHQGS 128



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 24/76 (31%), Positives = 29/76 (38%), Gaps = 8/76 (10%)

Query: 244 SGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSE 303
           S  GS  QSG      +   N GS   G +S S SG      S      SG         
Sbjct: 2   SDSGSYGQSGGEQQSYSTYGNPGSQGYGQASQSYSGYGQTTDSSYGQNYSG--------Y 53

Query: 304 SSWGSSTGSSSGNHGG 319
           SS+G S    S ++GG
Sbjct: 54  SSYGQSQSGYSQSYGG 69


>gi|47132620 keratin 2 [Homo sapiens]
          Length = 639

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 51/113 (45%), Positives = 60/113 (53%), Gaps = 8/113 (7%)

Query: 236 GSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG--SSGGSSGGSSGNS 293
           GSGG  S+SGGG  S S S GSG     + G S GG   GS SGG   SGG SGG  G+ 
Sbjct: 520 GSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGG---GSISGGGYGSGGGSGGRYGSG 576

Query: 294 GGSRGDSGSESSWGSSTG---SSSGNHGGSGGGNGHKPGCEKPGNEARGSGES 343
           GGS+G S S   +GS  G   S  G+ GGS  G G+  G     +    SGE+
Sbjct: 577 GGSKGGSISGGGYGSGGGKHSSGGGSRGGSSSGGGYGSGGGGSSSVKGSSGEA 629



 Score = 79.3 bits (194), Expect = 5e-15
 Identities = 54/130 (41%), Positives = 64/130 (49%), Gaps = 17/130 (13%)

Query: 196 GGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSS 255
           GG+GG        +G+ +  GY S  +S  + G  +    GSGGG S SGGG GS  GS 
Sbjct: 519 GGSGG--------RGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYGSGGGSG 570

Query: 256 GSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSG 315
           G   +G        GGS  GS SGG  G S GG   + GGSRG S S   +GS  G SS 
Sbjct: 571 GRYGSG--------GGSKGGSISGGGYG-SGGGKHSSGGGSRGGSSSGGGYGSGGGGSSS 621

Query: 316 NHGGSGGGNG 325
             G SG   G
Sbjct: 622 VKGSSGEAFG 631



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 43/107 (40%), Positives = 51/107 (47%), Gaps = 5/107 (4%)

Query: 241 SSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSG---GSSGGSSGGSSGNSGGSR 297
           SS       S++   GSG  G ++ G  S GSSS  S G   GS GGS GG S + GG  
Sbjct: 505 SSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGGGYG 564

Query: 298 GDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESG 344
              GS   +GS  GS  G+   SGGG G   G    G  +RG   SG
Sbjct: 565 SGGGSGGRYGSGGGSKGGSI--SGGGYGSGGGKHSSGGGSRGGSSSG 609



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 55/147 (37%), Positives = 65/147 (44%), Gaps = 38/147 (25%)

Query: 155 GGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQ 214
           GG GG+G  + GG  +       G+S+   G    G+  G GG G           +++ 
Sbjct: 519 GGSGGRGSSSGGGYSS-------GSSSYGSGGRQSGSRGGSGGGG-----------SISG 560

Query: 215 PGYGSVRASNQNEGCTNPPPSGSGGGS---SNSGGGSGSQSGSSGSGSNGDNNNGSSSGG 271
            GYGS   S    G        SGGGS   S SGGG GS  G   SG       G S GG
Sbjct: 561 GGYGSGGGSGGRYG--------SGGGSKGGSISGGGYGSGGGKHSSG-------GGSRGG 605

Query: 272 SSSGSSSGGSSGGSSG--GSSGNSGGS 296
           SSSG   G   GGSS   GSSG + GS
Sbjct: 606 SSSGGGYGSGGGGSSSVKGSSGEAFGS 632



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 57/177 (32%), Positives = 69/177 (38%), Gaps = 13/177 (7%)

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG 253
           G+GG GG    G ++  AV     G  R S  +  C +      GGG    GGG GS+  
Sbjct: 11  GRGGGGGGFR-GFSSGSAVVS---GGSRRSTSSFSCLS---RHGGGGGGFGGGGFGSR-- 61

Query: 254 SSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS--GGSRGDSGSESSWGSSTG 311
            S  G  G  +   S  G   G  + G  GG  GG  G S  GG  G SG     G   G
Sbjct: 62  -SLVGLGGTKSISISVAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGG 120

Query: 312 SSSGNHGGSGGGNG-HKPGCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSK 367
              G  GG GG  G   PG   PG    G  E  +  S   P     D   +N K++
Sbjct: 121 GRFGGFGGPGGVGGLGGPGGFGPGGYPGGIHEVSVNQSLLQPLNVKVDPEIQNVKAQ 177



 Score = 56.2 bits (134), Expect = 5e-08
 Identities = 45/135 (33%), Positives = 52/135 (38%), Gaps = 20/135 (14%)

Query: 229 CTNPPPSGSGGGSSNSGGGSGSQSGSS---------------GSGSNGDNNNGSSS---- 269
           C +    G GGG      GS   SG S               G G  G    GS S    
Sbjct: 7   CKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSFSCLSRHGGGGGGFGGGGFGSRSLVGL 66

Query: 270 GGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPG 329
           GG+ S S S  + GG   G++G  GG  G  G  SS+G  +G S G  GG G G G   G
Sbjct: 67  GGTKSISIS-VAGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGG 125

Query: 330 CEKPGNEARGSGESG 344
              PG      G  G
Sbjct: 126 FGGPGGVGGLGGPGG 140



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 43/121 (35%), Positives = 54/121 (44%), Gaps = 14/121 (11%)

Query: 137 GHNGAWETSGGHGIFGSQG-GLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQ 195
           G  G   +SGG    GS   G GG+  G+ GG G        G S    G    G   G+
Sbjct: 520 GSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGG-------GGSISGGGYGSGGGSGGR 572

Query: 196 GGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSS 255
            G+GG    G+ + G     GYGS    + + G +    S SGGG  + GGGS S  GSS
Sbjct: 573 YGSGGGSKGGSISGG-----GYGSGGGKHSSGGGSRGG-SSSGGGYGSGGGGSSSVKGSS 626

Query: 256 G 256
           G
Sbjct: 627 G 627



 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 37/104 (35%), Positives = 46/104 (44%), Gaps = 5/104 (4%)

Query: 244 SGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSR-GDSGS 302
           SG  S + + S  S +   N    ++ G S G  S    G SSG SS  SGG + G  G 
Sbjct: 492 SGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGG 551

Query: 303 ESSWGSSTGSSSGNHGGSGG----GNGHKPGCEKPGNEARGSGE 342
               GS +G   G+ GGSGG    G G K G    G    G G+
Sbjct: 552 SGGGGSISGGGYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGK 595



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 32/90 (35%), Positives = 41/90 (45%), Gaps = 5/90 (5%)

Query: 260 NGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGG 319
           +GD ++  +   +SS  SS  +S  + GGS G    S G   S SS   S G  SG+ GG
Sbjct: 492 SGDLSSNVTVSVTSSTISSNVASKAAFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGG 551

Query: 320 SGG-----GNGHKPGCEKPGNEARGSGESG 344
           SGG     G G+  G    G    G G  G
Sbjct: 552 SGGGGSISGGGYGSGGGSGGRYGSGGGSKG 581



 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 27/66 (40%), Positives = 31/66 (46%), Gaps = 5/66 (7%)

Query: 145 SGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQ-----GAPWGQGGNG 199
           +GG G FG+ GG GG+G G  GG       G+ G   G  G         G P G GG G
Sbjct: 77  AGGGGGFGAAGGFGGRGGGFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGPGGVGGLG 136

Query: 200 GPPNFG 205
           GP  FG
Sbjct: 137 GPGGFG 142



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 48/180 (26%), Positives = 55/180 (30%), Gaps = 37/180 (20%)

Query: 15  CLGSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQG 74
           C   G  G    G    G + G A+  G G   S      + +  GG  G       G G
Sbjct: 7   CKSRGRGG---GGGGFRGFSSGSAVVSG-GSRRSTSSFSCLSRHGGGGGG------FGGG 56

Query: 75  TREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQG 134
                G G R + G G   ++   V       G  G   GR                   
Sbjct: 57  -----GFGSRSLVGLGGTKSISISVAGGGGGFGAAGGFGGRGG----------------- 94

Query: 135 VPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWG 194
             G  G     GG G  G   G GG G G  GG G P   G  G   G  G  P G P G
Sbjct: 95  --GFGGGSSFGGGSGFSGGGFGGGGFGGGRFGGFGGP---GGVGGLGGPGGFGPGGYPGG 149



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 22/54 (40%), Positives = 25/54 (46%), Gaps = 5/54 (9%)

Query: 272 SSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNG 325
           S      GG  GG  G SSG++  S G   S SS+     S    HGG GGG G
Sbjct: 6   SCKSRGRGGGGGGFRGFSSGSAVVSGGSRRSTSSF-----SCLSRHGGGGGGFG 54



 Score = 34.7 bits (78), Expect = 0.15
 Identities = 39/146 (26%), Positives = 53/146 (36%), Gaps = 30/146 (20%)

Query: 38  ALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGN 97
           A G   G   S G G + G  + G+ G +     G G   ++  G     G+G+    G 
Sbjct: 517 AFGGSGGRGSSSGGGYSSGSSSYGSGGRQSGSRGGSGGGGSISGG-----GYGSGGGSGG 571

Query: 98  RVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGL 157
           R G    + G +                  + G   G  G  G   +SGG    GS  G 
Sbjct: 572 RYGSGGGSKGGS------------------ISG---GGYGSGGGKHSSGGGSRGGSSSG- 609

Query: 158 GGQGQGNPGGLGTPWVHGYPGNSAGS 183
           GG G G   G G+  V G  G + GS
Sbjct: 610 GGYGSG---GGGSSSVKGSSGEAFGS 632



 Score = 28.9 bits (63), Expect = 8.2
 Identities = 25/87 (28%), Positives = 34/87 (39%), Gaps = 9/87 (10%)

Query: 17  GSGEAGPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSE-ALGQGT 75
           GSG  G +  G        G   G G G     G G   G  +GG  GS   + + G G+
Sbjct: 551 GSGGGGSISGG--------GYGSGGGSGGRYGSGGGSKGGSISGGGYGSGGGKHSSGGGS 602

Query: 76  REAVGTGVRQVPGFGAADALGNRVGEA 102
           R    +G     G G + ++    GEA
Sbjct: 603 RGGSSSGGGYGSGGGGSSSVKGSSGEA 629


>gi|34740329 heterogeneous nuclear ribonucleoprotein A3 [Homo
           sapiens]
          Length = 378

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 68/193 (35%), Positives = 82/193 (42%), Gaps = 31/193 (16%)

Query: 130 GSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQ 189
           GS +G  G +G +   GG+  FG  GG  G+G GN GG G     GY G   GS G    
Sbjct: 211 GSQRGRGGGSGNFMGRGGN--FGGGGGNFGRG-GNFGGRG-----GYGGGGGGSRGS--- 259

Query: 190 GAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249
              +G GG+GG   FG +       PGY S                G G G  N GGG G
Sbjct: 260 ---YG-GGDGGYNGFGGDGGNYGGGPGYSSRGGYG-----------GGGPGYGNQGGGYG 304

Query: 250 SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSS 309
                 G G +G N  G+  GG+  G  +    G  SG    N G  +G S    S GS 
Sbjct: 305 G-----GGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSP 359

Query: 310 TGSSSGNHGGSGG 322
            G   G+ GGSGG
Sbjct: 360 YGGGYGSGGGSGG 372



 Score = 72.0 bits (175), Expect = 8e-13
 Identities = 65/196 (33%), Positives = 81/196 (41%), Gaps = 37/196 (18%)

Query: 152 GSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGA 211
           GSQ G GG G GN  G G            G+FG    G  +G+GGN G        +G 
Sbjct: 211 GSQRGRGG-GSGNFMGRG------------GNFGGG--GGNFGRGGNFGG-------RGG 248

Query: 212 VAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG-SQSGSSGSGSNGDNNNGSSSG 270
               G GS  +    +G  N    G GG   N GGG G S  G  G G  G  N G   G
Sbjct: 249 YGGGGGGSRGSYGGGDGGYN----GFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYG 304

Query: 271 GSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGN--GHKP 328
           G       GG  G + GG+ G  GG+ G  G+ + +G+ +G    N+G   GG+  G   
Sbjct: 305 G------GGGYDGYNEGGNFG--GGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSS 356

Query: 329 GCEKPGNEARGSGESG 344
           G    G    G G  G
Sbjct: 357 GSPYGGGYGSGGGSGG 372



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 48/131 (36%), Positives = 54/131 (41%), Gaps = 14/131 (10%)

Query: 236 GSGGGSSN---SGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSG--GSS 290
           G GGGS N    GG  G   G+ G G N     G   GG  S  S GG  GG +G  G  
Sbjct: 215 GRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDG 274

Query: 291 GNSGGSRGDS--GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGE------ 342
           GN GG  G S  G     G   G+  G +GG GG +G+  G    G    G G       
Sbjct: 275 GNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGN 334

Query: 343 -SGIQNSETSP 352
            SG Q S   P
Sbjct: 335 YSGQQQSNYGP 345



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 44/126 (34%), Positives = 54/126 (42%), Gaps = 4/126 (3%)

Query: 237 SGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSS-GGSSGGSSGGSSGNSGG 295
           S G     GGGSG+  G  G+   G  N G   GG+  G    GG  GGS G   G  GG
Sbjct: 209 SAGSQRGRGGGSGNFMGRGGNFGGGGGNFGR--GGNFGGRGGYGGGGGGSRGSYGGGDGG 266

Query: 296 SRGDSGSESSWGSSTG-SSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPGM 354
             G  G   ++G   G SS G +GG G G G++ G    G    G  E G        G 
Sbjct: 267 YNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGYDGYNEGGNFGGGNYGGG 326

Query: 355 FNFDTF 360
            N++ F
Sbjct: 327 GNYNDF 332



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 52/173 (30%), Positives = 64/173 (36%), Gaps = 23/173 (13%)

Query: 186 MNPQGAPWGQGGNGGPPNF---GTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSS 242
           M   G+  G+GG  G  NF   G N  G     G G                 G  GG  
Sbjct: 207 MQSAGSQRGRGGGSG--NFMGRGGNFGGGGGNFGRGG--------------NFGGRGGYG 250

Query: 243 NSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGS 302
             GGGS    G    G NG   +G + GG    SS GG  GG  G   GN GG  G  G 
Sbjct: 251 GGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPG--YGNQGGGYGGGGG 308

Query: 303 ESSWGSSTGSSSGNHGGSGGGN--GHKPGCEKPGNEARGSGESGIQNSETSPG 353
              +        GN+GG G  N  G+  G ++        G  G ++S +  G
Sbjct: 309 YDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSSGSPYG 361



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 65/212 (30%), Positives = 84/212 (39%), Gaps = 37/212 (17%)

Query: 51  VGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTG 110
           V KA+ K+   +AGS+     G G+   +G G     G G     GN  G   +  G  G
Sbjct: 198 VKKALSKQEMQSAGSQ--RGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGG 255

Query: 111 HEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGT 170
                   D   +G     G++ G PG++      GG   +G+QGG    G G  GG   
Sbjct: 256 SRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGNQGG----GYGGGGG--- 308

Query: 171 PWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCT 230
               GY  N  G+FG    G  +G GGN    +FG                 S Q +   
Sbjct: 309 --YDGY--NEGGNFG----GGNYGGGGNYN--DFG---------------NYSGQQQSNY 343

Query: 231 NPPPSGSGGGSSNS---GGGSGSQSGSSGSGS 259
            P   GS GG S+    GGG GS  GS G GS
Sbjct: 344 GPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGS 375



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 39/116 (33%), Positives = 46/116 (39%), Gaps = 16/116 (13%)

Query: 251 QSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSG-----GSSGGSSGNSGGSRGDSGSESS 305
           QS  S  G  G + N    GG+  G   GG+ G     G  GG  G  GGSRG  G    
Sbjct: 208 QSAGSQRGRGGGSGNFMGRGGNFGGG--GGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDG 265

Query: 306 WGSSTGSSSGNHGGS------GGGNGHKPGCEKPGNEARGSGESGIQNSETSPGMF 355
             +  G   GN+GG       GG  G  PG    GN+  G G  G  +     G F
Sbjct: 266 GYNGFGGDGGNYGGGPGYSSRGGYGGGGPGY---GNQGGGYGGGGGYDGYNEGGNF 318



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 28/85 (32%), Positives = 36/85 (42%), Gaps = 3/85 (3%)

Query: 259 SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHG 318
           S  +  +  S  G   GS +    GG+ GG  GN G   G+ G    +G   G S G++G
Sbjct: 203 SKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRG-GNFGGRGGYGGGGGGSRGSYG 261

Query: 319 GSGGGNGHKPGCEKPGNEARGSGES 343
           G  GG     G    GN   G G S
Sbjct: 262 GGDGGYNGFGG--DGGNYGGGPGYS 284



 Score = 36.2 bits (82), Expect = 0.051
 Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 7/70 (10%)

Query: 257 SGSNGDNNNGSSSGGSSSGSSSGGSSGGSSG--GSSGNSGGSRGDSGSESSWGSSTGSSS 314
           +G N +     S     S  S  G  GGS    G  GN GG  G+ G   ++G       
Sbjct: 192 NGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRGGNFGGR----- 246

Query: 315 GNHGGSGGGN 324
           G +GG GGG+
Sbjct: 247 GGYGGGGGGS 256


>gi|110735435 collagen, type V, alpha 3 preproprotein [Homo sapiens]
          Length = 1745

 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 101/354 (28%), Positives = 128/354 (36%), Gaps = 36/354 (10%)

Query: 19   GEAGPL-QSGEESTGTNIGEALGHGL-GDALSEGVGKAIGKEAGGAAGSKVSEALGQGTR 76
            G  GP+  +G       +G A G GL G + SEG          G AG K S    +G R
Sbjct: 998  GPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEG--------PVGPAGKKGS----RGER 1045

Query: 77   EAVG-TGVRQVPG----FGAADALGNRVGEAAHA-LGNTGHEIGRQAE-DVIRHGADAVR 129
               G TG   +PG     G   A G    E     +G  GH+  +  + D    G   +R
Sbjct: 1046 GPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGDAGPPGQPGIR 1105

Query: 130  G--SWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHGYPGNSAGS 183
            G     G PG +GA    G  G+FG +G  G +G     G PG  G P   G  G     
Sbjct: 1106 GPAGHPGPPGADGAQGRRGPPGLFGQKGDDGVRGFVGVIGPPGLQGLPGPPGEKGEVGDV 1165

Query: 184  FGMNPQGAPWGQGGNGGPPNFGT-NTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSS 242
              M P GAP  +G  G   + GT    G V QPG    +    + G   PP +    G  
Sbjct: 1166 GSMGPHGAPGPRGPQGPTGSEGTPGLPGGVGQPGAVGEKGERGDAGDPGPPGAPGIPGPK 1225

Query: 243  NSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDS 300
               G  G    S  +G  G        G   S   +G        G  G SG  GS G+ 
Sbjct: 1226 GDIGEKGDSGPSGAAGPPGKKGPPGEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEK 1285

Query: 301  GSESS-WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
            G      G     +SG  G  G      PG   P       G  G + ++  PG
Sbjct: 1286 GDPGDVGGPGPPGASGEPGAPG-----PPGKRGPSGHMGREGREGEKGAKGEPG 1334



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 72/259 (27%), Positives = 88/259 (33%), Gaps = 36/259 (13%)

Query: 123 HGADAVRGSWQ--GVPGHNGAWETSGGHGIFGSQGGLGGQG----------QGNPGGLGT 170
           HG+  + G     G PG  G     G  G+ GS G LG  G          QG PG  G 
Sbjct: 646 HGSQGLPGPQGLIGTPGEKGPPGNPGIPGLPGSDGPLGHPGHEGPTGEKGAQGPPGSAGP 705

Query: 171 PWVHGYPGNSA--GSFGMNPQGAPWGQGGNGGPPNF--GTNTQGAVAQPGYGSVRASNQN 226
           P   GYPG     G+ G        G+ G  G P F      +G   +PG    R  +  
Sbjct: 706 P---GYPGPRGVKGTSGNRGLQGEKGEKGEDGFPGFKGDVGLKGDQGKPGAPGPRGEDGP 762

Query: 227 EGCTNPPPSGSGGGSSNSG-GGSGSQSGSSG-------SGSNGDNNNGSSSGGSSSGSSS 278
           EG     P G  G +   G  GS  + G  G        G  G   +    G        
Sbjct: 763 EG-----PKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPGPLGPIGEK 817

Query: 279 GGSSGGSSGGSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHK--PGCEKPG 334
           G S      G  G  G  GSRG+ G   + G           G+ G  G K  PG + P 
Sbjct: 818 GKSGKTGQPGLEGERGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPP 877

Query: 335 NEARGSGESGIQNSETSPG 353
                 G  G Q  +  PG
Sbjct: 878 GFPGPKGPPGHQGKDGRPG 896



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 73/274 (26%), Positives = 90/274 (32%), Gaps = 59/274 (21%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHGYPGNSAGSFGMNPQ 189
            G+PG  G     G  G  G +G  G QG+    G+PG  G     G  G    +  + PQ
Sbjct: 863  GIPGEKGLPGLQGPPGFPGPKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQ 922

Query: 190  G-----APWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPP-PSGSGGGSSN 243
            G      P G+ G  GPP       G   + G   +      +G   PP P G  G +  
Sbjct: 923  GKTGEVGPLGERGPPGPP-------GPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGL 975

Query: 244  SG--GGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSG--GSSGGSS-GGSSGNSG---- 294
             G  G  G       +G  GD       G + S    G  G +GG    G SG+ G    
Sbjct: 976  RGFPGPKGGPGDPGPTGLKGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVGP 1035

Query: 295  ----GSRGDSGSESSWGSS-------------TGSSSGNHGGSG--GGNGHK-------- 327
                GSRG+ G     G                   SG  G  G  G  GHK        
Sbjct: 1036 AGKKGSRGERGPPGPTGKDGIPGPLGPLGPPGAAGPSGEEGDKGDVGAPGHKGSKGDKGD 1095

Query: 328  ------PGCEKPGNEARGSGESGIQNSETSPGMF 355
                  PG   P       G  G Q     PG+F
Sbjct: 1096 AGPPGQPGIRGPAGHPGPPGADGAQGRRGPPGLF 1129



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 75/293 (25%), Positives = 98/293 (33%), Gaps = 28/293 (9%)

Query: 66  KVSEALGQGTREAVG-TGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHG 124
           K+      G R   G TG +   GF     L    G+     G+ GH +G+        G
Sbjct: 528 KMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQR----GDFGH-VGQPGPP----G 578

Query: 125 ADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSF 184
            D  RG+ +G PG  G     G  G+ G +G        +PG  G P V G  G      
Sbjct: 579 EDGERGA-EGPPGPTGQAGEPGPRGLLGPRG--------SPGPTGRPGVTGIDGAPGAKG 629

Query: 185 GMNPQGAPW--GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSS 242
            + P G P   GQ GN G        QG +  PG    +    N G    P S    G  
Sbjct: 630 NVGPPGEPGPPGQQGNHGSQGL-PGPQGLIGTPG---EKGPPGNPGIPGLPGSDGPLGHP 685

Query: 243 NSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGS 302
              G +G +      GS G        G   +  + G        G  G   G +GD G 
Sbjct: 686 GHEGPTGEKGAQGPPGSAGPPGYPGPRGVKGTSGNRGLQGEKGEKGEDG-FPGFKGDVGL 744

Query: 303 ESSWGSSTGSSSGNHGGSGG--GNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
           +   G           G  G  G   + G E P   A   G+ G+      PG
Sbjct: 745 KGDQGKPGAPGPRGEDGPEGPKGQAGQAGEEGPPGSAGEKGKLGVPGLPGYPG 797



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 80/305 (26%), Positives = 102/305 (33%), Gaps = 35/305 (11%)

Query: 61   GAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDV 120
            G AG    E       E    GV  +PG+         +G     LG  G E G+  +  
Sbjct: 767  GQAGQAGEEGPPGSAGEKGKLGVPGLPGYPGRPGPKGSIGFPG-PLGPIG-EKGKSGKT- 823

Query: 121  IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGN 179
               G   + G  +G PG  G     G  G  G +G +G  G  G PG  G P + G PG 
Sbjct: 824  ---GQPGLEGE-RGPPGSRGERGQPGATGQPGPKGDVGQDGAPGIPGEKGLPGLQGPPGF 879

Query: 180  SAGSFGMNPQGAPWGQGGNGGPPNFG----TNTQGAVAQPGYGSVRASNQNEGCTNP--- 232
                    P+G P  QG +G P + G       QG    PG   V       G   P   
Sbjct: 880  PG------PKGPPGHQGKDGRPGHPGQRGELGFQGQTGPPGPAGVLGPQGKTGEVGPLGE 933

Query: 233  --PPSGSGGGSSNSGGGSGSQSGSSGS-GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGS 289
              PP   G        G   + G+ G  G  G       +G        GG       G 
Sbjct: 934  RGPPGPPGPPGEQGLPGLEGREGAKGELGPPGPLGKEGPAGLRGFPGPKGGPGDPGPTGL 993

Query: 290  SGNSG-----GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARG----S 340
             G+ G     G+ G  G     G + G       GS G  G  P  +K     RG    +
Sbjct: 994  KGDKGPPGPVGANGSPGERGPLGPAGGIGLPGQSGSEGPVG--PAGKKGSRGERGPPGPT 1051

Query: 341  GESGI 345
            G+ GI
Sbjct: 1052 GKDGI 1056



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 69/228 (30%), Positives = 81/228 (35%), Gaps = 19/228 (8%)

Query: 134 GVPGHNGAWETSGGHGIFGSQGGLGGQG-QGNPGGLGTPWVHGYPGNSAGSFGMNPQGAP 192
           G+PGH G     G  G  G QG  G QG  G PG +G     G PG + G+ G+     P
Sbjct: 494 GLPGHPG---LKGEEGAEGPQGPRGLQGPHGPPGRVGK---MGRPG-ADGARGLPGDTGP 546

Query: 193 WGQGGNGGPPNF-GTNTQ----GAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSG-- 245
            G  G  G P   G   Q    G V QPG          EG   P P+G  G     G  
Sbjct: 547 KGDRGFDGLPGLPGEKGQRGDFGHVGQPGPPGEDGERGAEG--PPGPTGQAGEPGPRGLL 604

Query: 246 GGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESS 305
           G  GS   +   G  G +    + G        G      + GS G   G +G  G+   
Sbjct: 605 GPRGSPGPTGRPGVTGIDGAPGAKGNVGPPGEPGPPGQQGNHGSQG-LPGPQGLIGTPGE 663

Query: 306 WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
            G           GS G  GH PG E P  E    G  G       PG
Sbjct: 664 KGPPGNPGIPGLPGSDGPLGH-PGHEGPTGEKGAQGPPGSAGPPGYPG 710



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 49/163 (30%), Positives = 66/163 (40%), Gaps = 15/163 (9%)

Query: 122  RHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQG-QGNPGGLGTPWVHGYPGNS 180
            R G +  +G+ +G PG +G    +G  G  G  G +G +G +G PG +G P + G PG  
Sbjct: 1320 REGREGEKGA-KGEPGPDGPPGRTGPMGARGPPGRVGPEGLRGIPGPVGEPGLLGAPGQM 1378

Query: 181  AGSFGMNPQGAPWGQGGNGGPPNFG-TNTQGAVAQPGYGSVRASNQNEGCTNPP-PSGSG 238
                 + P G P  +G  G     G     G +  PG    +      G   PP P G  
Sbjct: 1379 GPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEAGEKGDQGLPGVQGPPGPKGDP 1438

Query: 239  G-----GSSNSGGGSG-----SQSGSSGS-GSNGDNNNGSSSG 270
            G     GS    G  G      Q GS GS GS G   +   +G
Sbjct: 1439 GPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDTGPAG 1481



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 66/247 (26%), Positives = 74/247 (29%), Gaps = 38/247 (15%)

Query: 124  GADAVRGSW--QGVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHGYP 177
            G D  +GS    G+PG  G     G  GI GS G  G  G     G PG  G P   G P
Sbjct: 1250 GEDGAKGSVGPTGLPGDLGPPGDPGVSGIDGSPGEKGDPGDVGGPGPPGASGEPGAPGPP 1309

Query: 178  GNSAGSFGMNPQG-----------APWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQN 226
            G    S  M  +G            P G  G  GP        G V   G   +      
Sbjct: 1310 GKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMG-ARGPPGRVGPEGLRGI------ 1362

Query: 227  EGCTNPPPSGSGG--GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGG 284
                 P P G  G  G+    G  G    S   G  GD       G        G     
Sbjct: 1363 -----PGPVGEPGLLGAPGQMGPPGPLGPSGLPGLKGDTGPKGEKGHIGLIGLIGPPGEA 1417

Query: 285  SSGGSSGNSG-----GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHK--PGCEKPGNEA 337
               G  G  G     G +GD G     GS          G  G  G K  PG   P  + 
Sbjct: 1418 GEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGPRGDT 1477

Query: 338  RGSGESG 344
              +G  G
Sbjct: 1478 GPAGPPG 1484



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 61/228 (26%), Positives = 74/228 (32%), Gaps = 12/228 (5%)

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL-GTPWVHGYPGNSAGSFGMNPQG 190
           ++G PG  G     G  G  G  G  G  G   P GL G P + G  G       M  Q 
Sbjct: 390 FEGPPGAPGPQGVVGPSGPPGPPGFPGDPGPPGPAGLPGIPGIDGIRGPPGTVIMMPFQF 449

Query: 191 APWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCT-NPPPSGSGG--GSSNSGGG 247
           A  G    G P +F      AV Q    S++      G T  P P G  G  G     G 
Sbjct: 450 A--GGSFKGPPVSFQQAQAQAVLQQTQLSMKGPPGPVGLTGRPGPVGLPGHPGLKGEEGA 507

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSESS 305
            G Q      G +G        G   +  + G        G  G  G  G  G+ G    
Sbjct: 508 EGPQGPRGLQGPHGPPGRVGKMGRPGADGARGLPGDTGPKGDRGFDGLPGLPGEKGQRGD 567

Query: 306 WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
           +G           G  G  G  PG   P  +A   G  G+     SPG
Sbjct: 568 FGHVGQPGPPGEDGERGAEG-PPG---PTGQAGEPGPRGLLGPRGSPG 611



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 54/202 (26%), Positives = 67/202 (33%), Gaps = 28/202 (13%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHGYPGNSAGSFGMNPQ 189
            G PG  G    SG  G  G +G  G +G+    G PG  G     G PG   G  G+   
Sbjct: 1304 GAPGPPGKRGPSGHMGREGREGEKGAKGEPGPDGPPGRTGPMGARGPPGR-VGPEGLRGI 1362

Query: 190  GAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGG---------- 239
              P G+ G  G P       G +  PG          +G T   P G  G          
Sbjct: 1363 PGPVGEPGLLGAP-------GQMGPPGPLGPSGLPGLKGDTG--PKGEKGHIGLIGLIGP 1413

Query: 240  -GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GS 296
             G +   G  G        G  GD       G        G +      GS G+ G  G 
Sbjct: 1414 PGEAGEKGDQGLPGVQGPPGPKGDPGPPGPIGSLGHPGPPGVAGPLGQKGSKGSPGSMGP 1473

Query: 297  RGDSGSESSWGSSTGSSSGNHG 318
            RGD+G     G   G+ +  HG
Sbjct: 1474 RGDTGPAGPPG-PPGAPAELHG 1494



 Score = 32.7 bits (73), Expect = 0.57
 Identities = 25/78 (32%), Positives = 30/78 (38%), Gaps = 6/78 (7%)

Query: 133  QGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAP 192
            QG+PG  G     G  G  G  G +G  G   P G+  P   G  G+      M P+G  
Sbjct: 1423 QGLPGVQGP---PGPKGDPGPPGPIGSLGHPGPPGVAGPL--GQKGSKGSPGSMGPRG-D 1476

Query: 193  WGQGGNGGPPNFGTNTQG 210
             G  G  GPP       G
Sbjct: 1477 TGPAGPPGPPGAPAELHG 1494


>gi|4504733 insulin receptor substrate 4 [Homo sapiens]
          Length = 1257

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 51/144 (35%), Positives = 59/144 (40%), Gaps = 4/144 (2%)

Query: 200 GPPNFGT--NTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGS 257
           G  NFG   N QG   Q G G       N G  N   SG G GS+  G  S S  G+  S
Sbjct: 464 GSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCS 523

Query: 258 GSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNH 317
           G    +  G  S G  SG +     G  + G  G+ GG R   G  S  G   G   G+ 
Sbjct: 524 GEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSG 583

Query: 318 GG--SGGGNGHKPGCEKPGNEARG 339
           GG  SGGG G   G    G+  RG
Sbjct: 584 GGKNSGGGKGSGSGKGSDGDGERG 607



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 51/177 (28%), Positives = 68/177 (38%), Gaps = 14/177 (7%)

Query: 202 PNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGG---SSNSGGGSGSQSGSSGSG 258
           PN G      V+  G G+       +G       GSGG     +N G G+G  SG  G G
Sbjct: 450 PNNGARLSSEVSGSGSGNFGEEGNPQG--KEDQEGSGGDYMPMNNWGSGNGRGSGG-GQG 506

Query: 259 SNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHG 318
           SNG  ++  SSGG+       GS GG      G+ G      G  ++ G  +G      G
Sbjct: 507 SNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGG 566

Query: 319 GSGGGNGHKP--------GCEKPGNEARGSGESGIQNSETSPGMFNFDTFWKNFKSK 367
           G G G G  P        G    G +  GSG+    + E    +     F K  +SK
Sbjct: 567 GHGSGGGQGPGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSK 623



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 61/185 (32%), Positives = 72/185 (38%), Gaps = 46/185 (24%)

Query: 143 ETSG-GHGIFGSQGG-LGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGG 200
           E SG G G FG +G   G + Q   GG   P  +   GN  GS G        GQG NG 
Sbjct: 459 EVSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGG--------GQGSNG- 509

Query: 201 PPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSN 260
                   QG+                       S S GG+  SG G GS+    G GSN
Sbjct: 510 --------QGS----------------------SSHSSGGNQCSGEGQGSR---GGQGSN 536

Query: 261 GDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGS 320
           G  + G+       G++ G  SGG  G   G   GS G  G     GS  G +SG   GS
Sbjct: 537 GQGSGGNQCSRDGQGTAGGHGSGG--GQRPGGGHGSGGGQGPGDGHGSGGGKNSGGGKGS 594

Query: 321 GGGNG 325
           G G G
Sbjct: 595 GSGKG 599



 Score = 65.9 bits (159), Expect = 6e-11
 Identities = 54/172 (31%), Positives = 70/172 (40%), Gaps = 21/172 (12%)

Query: 157 LGGQGQGNPGGLGTPWVHGYPGNSAGSF-GMNPQGAPWGQGGNGGPPNFGTNTQGAVAQP 215
           + G G GN G  G P        S G +  MN  G+  G+G  GG    G+N QG+    
Sbjct: 460 VSGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQ---GSNGQGS---- 512

Query: 216 GYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSG 275
              S  +S  N+ C+       GG  SN  G  G+Q    G G+ G + +G   GG   G
Sbjct: 513 ---SSHSSGGNQ-CSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSG---GGQRPG 565

Query: 276 SSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHK 327
              G  SGG  G   G+  G     G  S  G  +GS  G+ G    G   K
Sbjct: 566 GGHG--SGGGQGPGDGHGSG----GGKNSGGGKGSGSGKGSDGDGERGKSLK 611



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 56/200 (28%), Positives = 84/200 (42%), Gaps = 21/200 (10%)

Query: 59  AGGAAGSKVSEALGQGTREAVGTGVRQVP--GFGAADALGNRVGEAAHALGNTGHEIGRQ 116
           +G  +G+   E   QG  +  G+G   +P   +G+ +  G+  G+ ++  G++ H  G  
Sbjct: 461 SGSGSGNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGN 520

Query: 117 AEDVIRHGADAVRGS-WQGVPGHNGAWE---TSGGHGIFGSQGGLGGQGQGNPGGLGTPW 172
                  G+   +GS  QG  G+  + +   T+GGHG  G Q   GG G G  GG G   
Sbjct: 521 QCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSG--GGQG--- 575

Query: 173 VHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNE----- 227
               PG+  GS G    G   G G   G    G   +    +  +G +  S Q +     
Sbjct: 576 ----PGDGHGSGGGKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPP 631

Query: 228 -GCTNPPPSGSGGGSSNSGG 246
                PPP+G  GG   SGG
Sbjct: 632 PPPPPPPPAGGTGGKGKSGG 651


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 75.9 bits (185), Expect = 6e-14
 Identities = 66/236 (27%), Positives = 86/236 (36%), Gaps = 16/236 (6%)

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL----GTPWVHGYPGNSAGSFGMN 187
           + G+ G  G    +G  G  GS G  G  GQ  P GL    G P   G P  + G+ G  
Sbjct: 270 FSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPG-PAGARGNDGAT 328

Query: 188 PQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGG 247
               P G  G  GPP F     GA  + G    R S   +G    P      G++   G 
Sbjct: 329 GAAGPPGPTGPAGPPGF-PGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGN 387

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG-----GSRGDSGS 302
            G+       G+NG      + G   +   SG    G   G  GNSG     GS+GD+G+
Sbjct: 388 PGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGA 447

Query: 303 ESSWG----SSTGSSSGNHGGSGG-GNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
           +   G          +G  G  G  G     G   P  E  G G  G   ++   G
Sbjct: 448 KGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAG 503



 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 92/344 (26%), Positives = 121/344 (35%), Gaps = 52/344 (15%)

Query: 52   GKAIGKEAGGAAGSKVSEALGQGTREAVGT----GVRQVPGFGAADALGNRVGEAAHALG 107
            G A  + A GA G+  ++    G   A G+    G++ +PG   A  L    G+   A G
Sbjct: 692  GPAGPRGANGAPGNDGAKG-DAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDA-G 749

Query: 108  NTGHEIGRQAEDVIRHGADAVRGSWQ-GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPG 166
              G + G   +D +R     +      G PG  G    SG  G  G++G  G +G+  P 
Sbjct: 750  PKGAD-GSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPP 808

Query: 167  G----LGTPWVHGYPG--NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSV 220
            G     G P   G PG     G  G      P G  G  GPP       G V  PG    
Sbjct: 809  GPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPG----PIGNVGAPGAKGA 864

Query: 221  RASNQNEGCTN----------PPPSGSGG-----GSSNSGGGSGSQSGSSGSGSNGDNNN 265
            R S    G T           P PSG+ G     G +   GG G +  +  +G  G+   
Sbjct: 865  RGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGP 924

Query: 266  GSSSGGSSSGSSSGGSSGGSSGGSSGNSG-----------GSRGDSGSESSWGSSTGSSS 314
                G +    S G      + G+ G  G           G RG+ G     G S     
Sbjct: 925  PGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGK 984

Query: 315  GNHGGSGGGNG-----HKPGCEKPGNEARGSGESGIQNSETSPG 353
                G+ G  G       PG   P  E   SG  G   +E SPG
Sbjct: 985  QGPSGASGERGPPGPMGPPGLAGPPGE---SGREGAPGAEGSPG 1025



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 78/290 (26%), Positives = 100/290 (34%), Gaps = 37/290 (12%)

Query: 59  AGGAAGSKVSEALGQGTREAVGT-------GVRQVPGFGAADALGNRVGEAAHALGNTGH 111
           A G AG K  EA  QG     G        G    PGF          GEA    G  G 
Sbjct: 606 AVGPAG-KDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEA----GKPGE 660

Query: 112 EIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQ-------GN 164
           +      D+   G    RG  +G PG  G     G  G  G+ G  G  G        G 
Sbjct: 661 Q--GVPGDLGAPGPSGARGE-RGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGA 717

Query: 165 PGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASN 224
           PG  G P + G PG   G+ G+     P G  G+ GP       +GA   PG   VR   
Sbjct: 718 PGSQGAPGLQGMPGER-GAAGLP---GPKGDRGDAGP-------KGADGSPGKDGVRGLT 766

Query: 225 QNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGG 284
              G   PP      G     G SG    +   G+ GD       G +      G     
Sbjct: 767 ---GPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQP 823

Query: 285 SSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPG 334
            + G  G++G ++GD+G     G +       + G+ G  G +     PG
Sbjct: 824 GAKGEPGDAG-AKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPG 872



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 95/348 (27%), Positives = 121/348 (34%), Gaps = 74/348 (21%)

Query: 59  AGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAE 118
           A G AG++ ++           TG    PGF  A      VG    A G  G +  R +E
Sbjct: 315 APGPAGARGNDGATGAAGPPGPTGPAGPPGFPGA------VG----AKGEAGPQGPRGSE 364

Query: 119 DVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPG 178
                G   VRG   G PG  GA   +G  G  G  G  G  G   PG  G P   G+PG
Sbjct: 365 -----GPQGVRGE-PGPPGPAGAAGPAGNPGADGQPGAKGANGA--PGIAGAP---GFPG 413

Query: 179 NSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQ-GAVAQPGYGSV------------RASNQ 225
               S    P G P  +G +G P   G+    GA  +PG   V            R +  
Sbjct: 414 ARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARG 473

Query: 226 NEGCTN--PPPSGSGG-------------GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSG 270
             G T    PP   GG             G     G  GS   +   GS G+      +G
Sbjct: 474 EPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAG 533

Query: 271 --GSSSGSSSGGSSG--GSSG--GSSGNSG--------GSRGDSGSESSWGSSTGSSSGN 316
             G+   + S GS G  G +G  G +G  G        G+RG +G     G    +    
Sbjct: 534 LPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPG 593

Query: 317 HGGSGG-----------GNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
             G  G           G   + G + P   A  +GE G Q    SPG
Sbjct: 594 KAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPG 641



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 66/247 (26%), Positives = 81/247 (32%), Gaps = 40/247 (16%)

Query: 133 QGVPGHNGAWETSGGHGIFGSQGGLGGQG----QGNPGGLGTPWVHGYPGNSAGSFGMNP 188
           +GVPG  GA   +G  G  G+QG  G  G    +G  G  G+P   G PG          
Sbjct: 598 RGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPG---------- 647

Query: 189 QGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASN---QNEGCTNPP----PSGSGGGS 241
              P G  G  G P       G +  PG    R         G   PP    P G+ G  
Sbjct: 648 ---PAGPPGEAGKPG-EQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAP 703

Query: 242 SNSG--------GGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNS 293
            N G        G  GSQ      G  G+       G       +G      S G  G  
Sbjct: 704 GNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVR 763

Query: 294 G-----GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHK--PGCEKPGNEARGSGESGIQ 346
           G     G  G +G+    G S  S      G+ G  G +  PG   P   A   G  G  
Sbjct: 764 GLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQP 823

Query: 347 NSETSPG 353
            ++  PG
Sbjct: 824 GAKGEPG 830



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 65/232 (28%), Positives = 80/232 (34%), Gaps = 30/232 (12%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQG--A 191
            G PG  GA  ++G  G  G  G  G  G   P G   P   G PG +    G  P+G   
Sbjct: 857  GAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGP--PGPPGPAGKEGGKGPRGETG 914

Query: 192  PWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGG--GSG 249
            P G+ G  GPP            PG    + S   +G    P +    G +   G  G  
Sbjct: 915  PAGRPGEVGPP----------GPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLP 964

Query: 250  SQSGSSG----SGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG-----GSRGDS 300
             Q G  G     G +G+      SG S      G        G  G SG     G+ G  
Sbjct: 965  GQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSP 1024

Query: 301  GSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSP 352
            G + S G+          G  G  G  PG   P   A  SG+ G    ET P
Sbjct: 1025 GRDGSPGAKGDRGETGPAGPPGAPG-APGAPGPVGPAGKSGDRG----ETGP 1071



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 62/232 (26%), Positives = 79/232 (34%), Gaps = 24/232 (10%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAGSFGMNPQGAP 192
            G  G  G     G  G  G QG  G  G+ G PG +G P + G PG S        +G+P
Sbjct: 965  GQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSP 1024

Query: 193  W-----------GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGS 241
                        G+ G  GPP       GA   PG       + + G T P       G 
Sbjct: 1025 GRDGSPGAKGDRGETGPAGPPG----APGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGP 1080

Query: 242  SNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSG 301
              + G +G Q      G  G+  +    G        G      S G  G SG S G +G
Sbjct: 1081 VGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGAS-GPAG 1139

Query: 302  SESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
                 GS+         G  G NG       PG   R +G++G       PG
Sbjct: 1140 PRGPPGSAGAP------GKDGLNGLPGPIGPPGPRGR-TGDAGPVGPPGPPG 1184



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 85/323 (26%), Positives = 117/323 (36%), Gaps = 50/323 (15%)

Query: 59  AGGAAGSKVSEALGQ-GTREAVGT-GVRQVPGF-GAADALGNR-VGEAAHALGNTGHEIG 114
           A G AG+  ++  GQ G + A G  G+   PGF GA    G +  G      GN+G    
Sbjct: 381 AAGPAGNPGAD--GQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEP-- 436

Query: 115 RQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL-GTPWV 173
                    GA   +G   G  G  G     G  G  G +G  G +G+  P GL G P  
Sbjct: 437 ---------GAPGSKGD-TGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGE 486

Query: 174 HGYPGNSA--GSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRA--------- 222
            G PG+    G+ G+     P G+ G+ GP      + G   +PG   +           
Sbjct: 487 RGGPGSRGFPGADGVAGPKGPAGERGSPGPAG-PKGSPGEAGRPGEAGLPGAKGLTGSPG 545

Query: 223 SNQNEGCTNPP----------PSGSGGGSSNSG--GGSGSQSGSSGSGSNGDNNNGSSSG 270
           S   +G T PP          P G  G    +G  G  G +  +   G  G+       G
Sbjct: 546 SPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPG 605

Query: 271 GSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKP 328
                   G +      G +G +G  G +G +GS    G    +      G  G  G   
Sbjct: 606 AVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPG 665

Query: 329 GCEKPG-NEARGS----GESGIQ 346
               PG + ARG     GE G+Q
Sbjct: 666 DLGAPGPSGARGERGFPGERGVQ 688



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 64/263 (24%), Positives = 94/263 (35%), Gaps = 49/263 (18%)

Query: 121 IRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQG-QGNPGGLGTPWVHGYPGN 179
           + +G D        VPG  G    SG  G+ G  G  G QG QG PG          PG 
Sbjct: 163 LSYGYDEKSTGGISVPGPMGP---SGPRGLPGPPGAPGPQGFQGPPGE---------PGE 210

Query: 180 SAGSFGMNPQGAPWGQGGNG--------------GPPNFGTNTQGAVAQPGYGSVRASNQ 225
              S  M P+G P   G NG              GPP      QGA   PG   +     
Sbjct: 211 PGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPP----GPQGARGLPGTAGLPGMKG 266

Query: 226 NEGCTNPPPSGSGGGSSNSGG--GSGSQSGSSGS----GSNGDNNNGSSSGGSSSGSSSG 279
           + G +    +    G +   G  GS  ++G+ G     G  G+     + G + +  + G
Sbjct: 267 HRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDG 326

Query: 280 GSSGGSSGGSSGNSG--------GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCE 331
            +      G +G +G        G++G++G +   GS          G  G  G      
Sbjct: 327 ATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAG 386

Query: 332 KPGNEARGSGESGIQNSETSPGM 354
            PG      G+ G + +  +PG+
Sbjct: 387 NPG----ADGQPGAKGANGAPGI 405



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 60/242 (24%), Positives = 76/242 (31%), Gaps = 25/242 (10%)

Query: 134 GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWV-HGYPGNSAGSFGMNPQGAP 192
           G PG +G     G  G+ G  G  G  G    GG   P + +GY   S G   +     P
Sbjct: 127 GPPGRDGI---PGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGP 183

Query: 193 WGQGGNGGPPNF--GTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGS 250
            G  G  GPP        QG   +PG           G   PP      G +   G  G 
Sbjct: 184 SGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGE 243

Query: 251 QSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSESSWG- 307
           +      G+ G        G       SG        G +G  G  GS G++G+    G 
Sbjct: 244 RGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGP 303

Query: 308 ------------SSTGSSSGNHG--GSGGGNGHKPGCEKPG--NEARGSGESGIQNSETS 351
                            + GN G  G+ G  G       PG        GE+G Q    S
Sbjct: 304 RGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGS 363

Query: 352 PG 353
            G
Sbjct: 364 EG 365



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 30/76 (39%), Positives = 34/76 (44%), Gaps = 8/76 (10%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHGYPGNSAGSFGMNPQ 189
            G PG  G    SG  G  G  G  G  G+    G PG +G P   G  G+ AG  G  P 
Sbjct: 1124 GSPGEQGPSGASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGD-AGPVG--PP 1180

Query: 190  GAPWGQGGNGGPPNFG 205
            G P G  G  GPP+ G
Sbjct: 1181 GPP-GPPGPPGPPSAG 1195



 Score = 35.8 bits (81), Expect = 0.067
 Identities = 29/85 (34%), Positives = 32/85 (37%), Gaps = 9/85 (10%)

Query: 133  QGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGG-LGTPWVHGYPGNSAGSFGMNPQGA 191
            +G+ GH G     G  G  GS G  G  G   P G  G P   G PG      G+N    
Sbjct: 1105 RGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGAPGKD----GLNGLPG 1160

Query: 192  PWGQGGNGGPPNFGTNTQGAVAQPG 216
            P G  G    P   T   G V  PG
Sbjct: 1161 PIGPPG----PRGRTGDAGPVGPPG 1181


>gi|14043070 heterogeneous nuclear ribonucleoprotein A1 isoform b
           [Homo sapiens]
          Length = 372

 Score = 75.5 bits (184), Expect = 8e-14
 Identities = 64/181 (35%), Positives = 83/181 (45%), Gaps = 16/181 (8%)

Query: 137 GHNGAWETSGGHGI-FGSQG--GLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPW 193
           G +G+    GG G  FG     G GG   G  G  G+    GY G+  G  G    G   
Sbjct: 195 GRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDG--- 251

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG 253
           G GG G   + G+   G+  Q GYG+  +     G  +   +G GGG    GGGSGS  G
Sbjct: 252 GYGGGGPGYSGGSRGYGSGGQ-GYGNQGSGYGGSGSYDSYNNGGGGGF---GGGSGSNFG 307

Query: 254 SSGSGSN-GDNNNGSSSGGSSSGSSSGGSSGGSSGG-----SSGNSGGSRGDSGSESSWG 307
             GS ++ G+ NN SS+ G   G + GG S G  GG     +   + G  G S S SS+G
Sbjct: 308 GGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYG 367

Query: 308 S 308
           S
Sbjct: 368 S 368



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 67/196 (34%), Positives = 76/196 (38%), Gaps = 36/196 (18%)

Query: 154 QGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVA 213
           + G G  G G  GG G     G  GN +G  G    G   G GG GG    G    G   
Sbjct: 196 RSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGF---GGSRGGGGYGGS---GDGYNGFGN 249

Query: 214 QPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSS 273
             GYG                   GGG   SGG  G      GSG  G  N GS  GGS 
Sbjct: 250 DGGYG-------------------GGGPGYSGGSRGY-----GSGGQGYGNQGSGYGGSG 285

Query: 274 SGSSSGGSSGGSSGGSSGNS---GGSRGDSGSESSWGSSTG-SSSGNHGG--SGGGNGHK 327
           S  S     GG  GG SG++   GGS  D G+ ++  S+ G    GN GG  SG   G  
Sbjct: 286 SYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGG 345

Query: 328 PGCEKPGNEARGSGES 343
               KP N+    G S
Sbjct: 346 QYFAKPRNQGGYGGSS 361



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 38/106 (35%), Positives = 48/106 (45%), Gaps = 1/106 (0%)

Query: 248 SGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWG 307
           S SQ G SGSG+ G    G   G  + G     S  G  GGS G  GG  G     + +G
Sbjct: 190 SSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGG-GGYGGSGDGYNGFG 248

Query: 308 SSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSPG 353
           +  G   G  G SGG  G+  G +  GN+  G G SG  +S  + G
Sbjct: 249 NDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGG 294



 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 46/130 (35%), Positives = 53/130 (40%), Gaps = 17/130 (13%)

Query: 240 GSSNSGGGSGSQSGSSGSGSNGDNNNGSSS-GGSSSGSSSGGS---------SGGSSGGS 289
           GS N GGG G   G + +   G N +G    GGS  G   GGS          GG  GG 
Sbjct: 198 GSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGG 257

Query: 290 SGNSGGSRG-DSGSE------SSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGE 342
            G SGGSRG  SG +      S +G S    S N+GG GG  G        G      G 
Sbjct: 258 PGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGN 317

Query: 343 SGIQNSETSP 352
              Q+S   P
Sbjct: 318 YNNQSSNFGP 327



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 41/127 (32%), Positives = 52/127 (40%), Gaps = 10/127 (7%)

Query: 235 SGSGGGSSNSGGGSGSQSGS------SGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGG 288
           SGSG      GGG G           SG G  G +  G   GGS  G +  G+ GG  GG
Sbjct: 197 SGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGG 256

Query: 289 SSGNSGGSRGDSGSESSWGS--STGSSSGNHGGS--GGGNGHKPGCEKPGNEARGSGESG 344
             G SGGSRG       +G+  S    SG++     GGG G   G            + G
Sbjct: 257 GPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFG 316

Query: 345 IQNSETS 351
             N+++S
Sbjct: 317 NYNNQSS 323



 Score = 35.4 bits (80), Expect = 0.088
 Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)

Query: 260 NGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS--GSESSWGSSTGSSSGNH 317
           NG N     +      +S+  S  G SG  SGN GG RG    G+++       S  G  
Sbjct: 171 NGHNCEVRKALSKQEMASASSSQRGRSG--SGNFGGGRGGGFGGNDNFGRGGNFSGRGGF 228

Query: 318 GGSGGGNGH 326
           GGS GG G+
Sbjct: 229 GGSRGGGGY 237



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 30/87 (34%), Positives = 34/87 (39%), Gaps = 8/87 (9%)

Query: 267 SSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH 326
           S+S      S SG   GG  GG  GN    RG + S        G   G+ GG GG  G 
Sbjct: 188 SASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFS------GRGGFGGSRGG-GGYGGS 240

Query: 327 KPGCEKPGNEARGSGESGIQNSETSPG 353
             G    GN+  G G  G   S  S G
Sbjct: 241 GDGYNGFGNDG-GYGGGGPGYSGGSRG 266


>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2
           [Homo sapiens]
          Length = 2191

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 73/301 (24%), Positives = 110/301 (36%), Gaps = 36/301 (11%)

Query: 54  AIGKEAGGAA--GSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGH 111
           ++G   GGA   G  + +    G +++   G    PG      L ++ G+   A    G 
Sbjct: 81  SLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPG----PPLLSKPGDEDDAPPKMGE 136

Query: 112 EIGRQAEDVIRHGADAVRGSWQ---GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL 168
             G + E    H      G+ Q    VPG  G          F +  G      G PGG 
Sbjct: 137 PAGGRYE----HPGLGALGTQQPPVAVPGGGGG---PAAVPEFNNYYGSAAPASGGPGGR 189

Query: 169 GTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEG 228
             P    + G  +   GM    +    G  G       + +G      Y + +  N   G
Sbjct: 190 AGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEG------YPNSQC-NHYPG 242

Query: 229 CTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGG 288
            + P   G GGG    GGGSG   G  G+G+ G      ++  +++ +++GG  GG  GG
Sbjct: 243 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 302

Query: 289 SSG---------NSGGSR----GDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGN 335
           SS            GG      G  G+ S   ++ GS++G      G N H  G     N
Sbjct: 303 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 362

Query: 336 E 336
           +
Sbjct: 363 Q 363



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 72/282 (25%), Positives = 99/282 (35%), Gaps = 36/282 (12%)

Query: 86  VPGFGAADA----LGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGA 141
           VPG G   A      N  G AA A G  G   GR      +HG        Q  PG    
Sbjct: 159 VPGGGGGPAAVPEFNNYYGSAAPASGGPG---GRAGPCFDQHGG-------QQSPGMGMM 208

Query: 142 WETSGGH-GIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGG 200
              S    G  GS   L    +G P      +  GY    AG  G    G   G GG GG
Sbjct: 209 HSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYP-GYSRPGAGGGGGGGGGGGGGSGGGGG 267

Query: 201 PPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSN 260
               G    GA A     +  A+             +GGG     GGS +  G   S   
Sbjct: 268 GGGAGAGGAGAGAVAAAAAAAAA------------AAGGGGGGGYGGSSAGYGVLSSPRQ 315

Query: 261 GDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSS---GNH 317
                    GG  + S S  ++G ++GG    +G ++  SG+  +      S S    ++
Sbjct: 316 QGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSY 375

Query: 318 GGS----GGGNGHKPGCEKPGNEARGSG-ESGIQNSETSPGM 354
           GGS       +   P   +P ++A  +G  +G Q +    G+
Sbjct: 376 GGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGL 417



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 79/329 (24%), Positives = 110/329 (33%), Gaps = 31/329 (9%)

Query: 19  GEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTRE 77
           G A P   G    G   G     HG   +   G+  +    A GA GS   + L      
Sbjct: 177 GSAAPASGGP---GGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSM--DPLQNSHEG 231

Query: 78  AVGTGVRQVPGF------GAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGS 131
              +     PG+      G     G   G +    G  G   G      +   A A   +
Sbjct: 232 YPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAA 291

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVH-GYPGNSAGSFGMNPQG 190
             G  G  G   +S G+G+  S    GG     PGG G   +     G++AG F    + 
Sbjct: 292 -AGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGF---QRF 347

Query: 191 APWGQGGNGGPPNFGTN-TQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249
           A   Q  +G  P      T  +     YG       +     PPPS     ++ +G  +G
Sbjct: 348 AGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAG 407

Query: 250 SQSGSSGSGSNGDNN----NGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS----- 300
            Q  ++G G   D        S +  ++   S    S G+ G + G S GS  D      
Sbjct: 408 GQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKR 467

Query: 301 ----GSESSWGSSTGSSSGNHGGSGGGNG 325
               G  S+  S    SS   GGS G  G
Sbjct: 468 PQLYGMGSNPHSQPQQSSPYPGGSYGPPG 496


>gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1
           [Homo sapiens]
          Length = 2231

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 73/301 (24%), Positives = 110/301 (36%), Gaps = 36/301 (11%)

Query: 54  AIGKEAGGAA--GSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGH 111
           ++G   GGA   G  + +    G +++   G    PG      L ++ G+   A    G 
Sbjct: 81  SLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPG----PPLLSKPGDEDDAPPKMGE 136

Query: 112 EIGRQAEDVIRHGADAVRGSWQ---GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL 168
             G + E    H      G+ Q    VPG  G          F +  G      G PGG 
Sbjct: 137 PAGGRYE----HPGLGALGTQQPPVAVPGGGGG---PAAVPEFNNYYGSAAPASGGPGGR 189

Query: 169 GTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEG 228
             P    + G  +   GM    +    G  G       + +G      Y + +  N   G
Sbjct: 190 AGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEG------YPNSQC-NHYPG 242

Query: 229 CTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGG 288
            + P   G GGG    GGGSG   G  G+G+ G      ++  +++ +++GG  GG  GG
Sbjct: 243 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 302

Query: 289 SSG---------NSGGSR----GDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGN 335
           SS            GG      G  G+ S   ++ GS++G      G N H  G     N
Sbjct: 303 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 362

Query: 336 E 336
           +
Sbjct: 363 Q 363



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 72/282 (25%), Positives = 99/282 (35%), Gaps = 36/282 (12%)

Query: 86  VPGFGAADA----LGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGA 141
           VPG G   A      N  G AA A G  G   GR      +HG        Q  PG    
Sbjct: 159 VPGGGGGPAAVPEFNNYYGSAAPASGGPG---GRAGPCFDQHGG-------QQSPGMGMM 208

Query: 142 WETSGGH-GIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGG 200
              S    G  GS   L    +G P      +  GY    AG  G    G   G GG GG
Sbjct: 209 HSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYP-GYSRPGAGGGGGGGGGGGGGSGGGGG 267

Query: 201 PPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSN 260
               G    GA A     +  A+             +GGG     GGS +  G   S   
Sbjct: 268 GGGAGAGGAGAGAVAAAAAAAAA------------AAGGGGGGGYGGSSAGYGVLSSPRQ 315

Query: 261 GDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSS---GNH 317
                    GG  + S S  ++G ++GG    +G ++  SG+  +      S S    ++
Sbjct: 316 QGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSY 375

Query: 318 GGS----GGGNGHKPGCEKPGNEARGSG-ESGIQNSETSPGM 354
           GGS       +   P   +P ++A  +G  +G Q +    G+
Sbjct: 376 GGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGL 417



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 79/329 (24%), Positives = 110/329 (33%), Gaps = 31/329 (9%)

Query: 19  GEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTRE 77
           G A P   G    G   G     HG   +   G+  +    A GA GS   + L      
Sbjct: 177 GSAAPASGGP---GGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSM--DPLQNSHEG 231

Query: 78  AVGTGVRQVPGF------GAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGS 131
              +     PG+      G     G   G +    G  G   G      +   A A   +
Sbjct: 232 YPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAA 291

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVH-GYPGNSAGSFGMNPQG 190
             G  G  G   +S G+G+  S    GG     PGG G   +     G++AG F    + 
Sbjct: 292 -AGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGF---QRF 347

Query: 191 APWGQGGNGGPPNFGTN-TQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249
           A   Q  +G  P      T  +     YG       +     PPPS     ++ +G  +G
Sbjct: 348 AGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAG 407

Query: 250 SQSGSSGSGSNGDNN----NGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS----- 300
            Q  ++G G   D        S +  ++   S    S G+ G + G S GS  D      
Sbjct: 408 GQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKR 467

Query: 301 ----GSESSWGSSTGSSSGNHGGSGGGNG 325
               G  S+  S    SS   GGS G  G
Sbjct: 468 PQLYGMGSNPHSQPQQSSPYPGGSYGPPG 496


>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3
           [Homo sapiens]
          Length = 2178

 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 73/301 (24%), Positives = 110/301 (36%), Gaps = 36/301 (11%)

Query: 54  AIGKEAGGAA--GSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGH 111
           ++G   GGA   G  + +    G +++   G    PG      L ++ G+   A    G 
Sbjct: 81  SLGGAGGGAPQPGPDMEQPQHGGAKDSAAGGQADPPG----PPLLSKPGDEDDAPPKMGE 136

Query: 112 EIGRQAEDVIRHGADAVRGSWQ---GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL 168
             G + E    H      G+ Q    VPG  G          F +  G      G PGG 
Sbjct: 137 PAGGRYE----HPGLGALGTQQPPVAVPGGGGG---PAAVPEFNNYYGSAAPASGGPGGR 189

Query: 169 GTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEG 228
             P    + G  +   GM    +    G  G       + +G      Y + +  N   G
Sbjct: 190 AGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEG------YPNSQC-NHYPG 242

Query: 229 CTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGG 288
            + P   G GGG    GGGSG   G  G+G+ G      ++  +++ +++GG  GG  GG
Sbjct: 243 YSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAAAGGGGGGGYGG 302

Query: 289 SSG---------NSGGSR----GDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGN 335
           SS            GG      G  G+ S   ++ GS++G      G N H  G     N
Sbjct: 303 SSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLN 362

Query: 336 E 336
           +
Sbjct: 363 Q 363



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 72/282 (25%), Positives = 99/282 (35%), Gaps = 36/282 (12%)

Query: 86  VPGFGAADA----LGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGA 141
           VPG G   A      N  G AA A G  G   GR      +HG        Q  PG    
Sbjct: 159 VPGGGGGPAAVPEFNNYYGSAAPASGGPG---GRAGPCFDQHGG-------QQSPGMGMM 208

Query: 142 WETSGGH-GIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGG 200
              S    G  GS   L    +G P      +  GY    AG  G    G   G GG GG
Sbjct: 209 HSASAAAAGAPGSMDPLQNSHEGYPNSQCNHYP-GYSRPGAGGGGGGGGGGGGGSGGGGG 267

Query: 201 PPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSN 260
               G    GA A     +  A+             +GGG     GGS +  G   S   
Sbjct: 268 GGGAGAGGAGAGAVAAAAAAAAA------------AAGGGGGGGYGGSSAGYGVLSSPRQ 315

Query: 261 GDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSS---GNH 317
                    GG  + S S  ++G ++GG    +G ++  SG+  +      S S    ++
Sbjct: 316 QGGGMMMGPGGGGAASLSKAAAGSAAGGFQRFAGQNQHPSGATPTLNQLLTSPSPMMRSY 375

Query: 318 GGS----GGGNGHKPGCEKPGNEARGSG-ESGIQNSETSPGM 354
           GGS       +   P   +P ++A  +G  +G Q +    G+
Sbjct: 376 GGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAGGQQAAAGMGL 417



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 79/329 (24%), Positives = 110/329 (33%), Gaps = 31/329 (9%)

Query: 19  GEAGPLQSGEESTGTNIGEALG-HGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTRE 77
           G A P   G    G   G     HG   +   G+  +    A GA GS   + L      
Sbjct: 177 GSAAPASGGP---GGRAGPCFDQHGGQQSPGMGMMHSASAAAAGAPGSM--DPLQNSHEG 231

Query: 78  AVGTGVRQVPGF------GAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGS 131
              +     PG+      G     G   G +    G  G   G      +   A A   +
Sbjct: 232 YPNSQCNHYPGYSRPGAGGGGGGGGGGGGGSGGGGGGGGAGAGGAGAGAVAAAAAAAAAA 291

Query: 132 WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVH-GYPGNSAGSFGMNPQG 190
             G  G  G   +S G+G+  S    GG     PGG G   +     G++AG F    + 
Sbjct: 292 -AGGGGGGGYGGSSAGYGVLSSPRQQGGGMMMGPGGGGAASLSKAAAGSAAGGF---QRF 347

Query: 191 APWGQGGNGGPPNFGTN-TQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSG 249
           A   Q  +G  P      T  +     YG       +     PPPS     ++ +G  +G
Sbjct: 348 AGQNQHPSGATPTLNQLLTSPSPMMRSYGGSYPEYSSPSAPPPPPSQPQSQAAAAGAAAG 407

Query: 250 SQSGSSGSGSNGDNN----NGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRGDS----- 300
            Q  ++G G   D        S +  ++   S    S G+ G + G S GS  D      
Sbjct: 408 GQQAAAGMGLGKDMGAQYAAASPAWAAAQQRSHPAMSPGTPGPTMGRSQGSPMDPMVMKR 467

Query: 301 ----GSESSWGSSTGSSSGNHGGSGGGNG 325
               G  S+  S    SS   GGS G  G
Sbjct: 468 PQLYGMGSNPHSQPQQSSPYPGGSYGPPG 496


>gi|212549553 interleukin enhancer binding factor 3 isoform d [Homo
           sapiens]
          Length = 898

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 84/283 (29%), Positives = 113/283 (39%), Gaps = 37/283 (13%)

Query: 87  PGFGAADALGNRVGEAAHALGN------TGHEIGRQAEDVIRHGADAVRGSWQGVPGHNG 140
           PGFG    + N V    +  G        G   GR       HG     G+  G  G+ G
Sbjct: 625 PGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGA-NHGGYMNAGAGYGSYGYGG 683

Query: 141 AWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGG 200
              T+G +  F S GG  G   G  GG G        G S+G +G   QG  +    +  
Sbjct: 684 NSATAG-YSQFYSNGGHSGNASGGGGGGG--------GGSSG-YGSYYQGDNYN---SPV 730

Query: 201 PPNFGTNTQ--GAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG-SSGS 257
           PP      Q  G   +P YGS   S+Q +       S +    SN G   G Q G + G 
Sbjct: 731 PPKHAGKKQPHGGQQKPSYGSGYQSHQGQ-----QQSYNQSPYSNYGPPQGKQKGYNHGQ 785

Query: 258 GSNGDNNNGSSSGGSSSGSSSGGS------SGGSSGGSSGNSGGSRGDSGSESSWGSSTG 311
           GS   +N+ +S GG      +  S      SGG SGG+S  SGG+  + GS   +G  +G
Sbjct: 786 GSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSG 845

Query: 312 SSSGNHGGSGGGNGHKPGCEKPGNEARGSG-ESGIQNSETSPG 353
             S   G  GG +  +     PG+    SG  S  Q+S+   G
Sbjct: 846 GGSSYQGKQGGYS--QSNYNSPGSGQNYSGPPSSYQSSQGGYG 886



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 50/160 (31%), Positives = 59/160 (36%), Gaps = 16/160 (10%)

Query: 138 HNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPW--VHGYPGNSAGSFGMNPQGAPWGQ 195
           H G  + S G G    QG      Q      G P     GY          N   +P G 
Sbjct: 741 HGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGG 800

Query: 196 GGNGGPPNFGTNTQGAVAQPG---YGSVRASNQNEGCTNPPPSGSGGGSSNSGGGS---G 249
           GG+        N  G+  + G   YGS  AS       NP   G  GG   SGGGS   G
Sbjct: 801 GGSDYNYESKFNYSGSGGRSGGNSYGSGGASY------NPGSHGGYGGG--SGGGSSYQG 852

Query: 250 SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGS 289
            Q G S S  N   +  + SG  SS  SS G  G ++  S
Sbjct: 853 KQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHS 892


>gi|24234750 interleukin enhancer binding factor 3 isoform a [Homo
           sapiens]
          Length = 894

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 84/283 (29%), Positives = 113/283 (39%), Gaps = 37/283 (13%)

Query: 87  PGFGAADALGNRVGEAAHALGN------TGHEIGRQAEDVIRHGADAVRGSWQGVPGHNG 140
           PGFG    + N V    +  G        G   GR       HG     G+  G  G+ G
Sbjct: 621 PGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGA-NHGGYMNAGAGYGSYGYGG 679

Query: 141 AWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGG 200
              T+G +  F S GG  G   G  GG G        G S+G +G   QG  +    +  
Sbjct: 680 NSATAG-YSQFYSNGGHSGNASGGGGGGG--------GGSSG-YGSYYQGDNYN---SPV 726

Query: 201 PPNFGTNTQ--GAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSG-SSGS 257
           PP      Q  G   +P YGS   S+Q +       S +    SN G   G Q G + G 
Sbjct: 727 PPKHAGKKQPHGGQQKPSYGSGYQSHQGQ-----QQSYNQSPYSNYGPPQGKQKGYNHGQ 781

Query: 258 GSNGDNNNGSSSGGSSSGSSSGGS------SGGSSGGSSGNSGGSRGDSGSESSWGSSTG 311
           GS   +N+ +S GG      +  S      SGG SGG+S  SGG+  + GS   +G  +G
Sbjct: 782 GSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSG 841

Query: 312 SSSGNHGGSGGGNGHKPGCEKPGNEARGSG-ESGIQNSETSPG 353
             S   G  GG +  +     PG+    SG  S  Q+S+   G
Sbjct: 842 GGSSYQGKQGGYS--QSNYNSPGSGQNYSGPPSSYQSSQGGYG 882



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 50/160 (31%), Positives = 59/160 (36%), Gaps = 16/160 (10%)

Query: 138 HNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPW--VHGYPGNSAGSFGMNPQGAPWGQ 195
           H G  + S G G    QG      Q      G P     GY          N   +P G 
Sbjct: 737 HGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGG 796

Query: 196 GGNGGPPNFGTNTQGAVAQPG---YGSVRASNQNEGCTNPPPSGSGGGSSNSGGGS---G 249
           GG+        N  G+  + G   YGS  AS       NP   G  GG   SGGGS   G
Sbjct: 797 GGSDYNYESKFNYSGSGGRSGGNSYGSGGASY------NPGSHGGYGGG--SGGGSSYQG 848

Query: 250 SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGS 289
            Q G S S  N   +  + SG  SS  SS G  G ++  S
Sbjct: 849 KQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHS 888


>gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo
           sapiens]
          Length = 940

 Score = 73.2 bits (178), Expect = 4e-13
 Identities = 72/215 (33%), Positives = 77/215 (35%), Gaps = 28/215 (13%)

Query: 152 GSQGGLGGQGQGNPGGLGT-PWVHGYPGNSAGSFGMNPQGAPWGQG----GNGGPPNFGT 206
           G  GG  G     PG  G  P  HG PG   G   + P   P G      G G P   G 
Sbjct: 632 GGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPPRGGDPFWDGPGDPMRGGP 691

Query: 207 NTQGAVAQPG-YGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNN 265
              G    PG Y   R          PPP   G     SGGG  +  G  G G  G   +
Sbjct: 692 MRGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSGGGPPNGRGGPGGGMVGGGGH 751

Query: 266 GSSSG-GSSSGSSSG-----GSSGGSS---------GGSSGNSGGSRGDSGSESSWGSST 310
               G G   G+SSG     G  GG           GGS G  GG R   G     G S 
Sbjct: 752 RPHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGGGHRPHEGPGG--GISG 809

Query: 311 GSSSGNHGGSGG----GNGHKPGCEKPGNEARGSG 341
           GS    H G GG    G GH+P  E PG    GSG
Sbjct: 810 GSGHRPHEGPGGGMGAGGGHRPH-EGPGGSMGGSG 843



 Score = 69.3 bits (168), Expect = 5e-12
 Identities = 65/203 (32%), Positives = 74/203 (36%), Gaps = 33/203 (16%)

Query: 158 GGQGQGNPGGLGTPWVHGYPGNSAGSFGMNP---QGAPWGQGGNGGPPNFGTNTQGAVAQ 214
           GG  +G PG    P+  G  G         P   +GA  G+ G GGPPN           
Sbjct: 689 GGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSG-GGPPN-------GRGG 740

Query: 215 PGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS--GSSGSGSNGDNNNGSSSGGS 272
           PG G V            P  G GGG  NS G    +   G  GSG       G S GG 
Sbjct: 741 PGGGMVGGGGHR------PHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGG 794

Query: 273 SSGSSSGGSSGGSSGGSS-----------GNSGGSRGDSGSESSWGSSTGSSSGNHGGSG 321
                  G  GG SGGS            G  GG R   G   S G S G       G G
Sbjct: 795 GGHRPHEGPGGGISGGSGHRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHEGPGHG 854

Query: 322 GGNGHKPGCEKPGNEARGSGESG 344
           G +GH+P  + PG+  RG    G
Sbjct: 855 GPHGHRPH-DVPGH--RGHDHRG 874



 Score = 63.2 bits (152), Expect = 4e-10
 Identities = 57/195 (29%), Positives = 66/195 (33%), Gaps = 21/195 (10%)

Query: 146 GGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFG 205
           GG    G   G GG G G  GG G     G  G    S G  P   P G  G+G  P+ G
Sbjct: 727 GGRSGGGPPNGRGGPGGGMVGGGGHRPHEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEG 786

Query: 206 TNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNN 265
                    PG       +   G  + P  G GGG S   G    +    G G+ G +  
Sbjct: 787 ---------PG------GSMGGGGGHRPHEGPGGGISGGSGHRPHEGPGGGMGAGGGHRP 831

Query: 266 GSSSGGSSSGSS-----SGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGS 320
               GGS  GS       G   GG  G    +  G RG            G     HGG 
Sbjct: 832 HEGPGGSMGGSGGHRPHEGPGHGGPHGHRPHDVPGHRGHDHRGPPPHEHRGHDGPGHGG- 890

Query: 321 GGGNGHKPGCEKPGN 335
           GG  GH  G    G+
Sbjct: 891 GGHRGHDGGHSHGGD 905



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 64/244 (26%), Positives = 75/244 (30%), Gaps = 57/244 (23%)

Query: 158 GGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNG-----------GPPNFGT 206
           GG G G+P G G   +     N  GS G      P G GG G           G PN   
Sbjct: 540 GGSG-GSPDGAGGSKLPPVLANLMGSMGAGK--GPQGPGGGGINVQEILTSIMGSPNSHP 596

Query: 207 NTQGAVAQPGYGS-VRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNN 265
           + +  + QP Y   ++      G   P P  +G      GG  G Q    G G      +
Sbjct: 597 SEE-LLKQPDYSDKIKQMLVPHGLLGPGPIANGFPPGGPGGPKGMQHFPPGPGGPMPGPH 655

Query: 266 GSSSG---------------------GSSSGSSSGGSSGGSSGG------SSGNSGGS-- 296
           G   G                     G       G   GG   G        G  GG+  
Sbjct: 656 GGPGGPVGPRLLGPPPPPRGGDPFWDGPGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEP 715

Query: 297 -------RGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSE 349
                  RG  G  S  G   G   G  GG  GG GH+P  E PG    G G S      
Sbjct: 716 PPPPPPFRGARGGRSGGGPPNG-RGGPGGGMVGGGGHRPH-EGPGG---GMGNSSGHRPH 770

Query: 350 TSPG 353
             PG
Sbjct: 771 EGPG 774



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 51/188 (27%), Positives = 63/188 (33%), Gaps = 29/188 (15%)

Query: 87  PGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSG 146
           PG G     G+R  E     G  G+  G +  +    G     GS  G   H G   + G
Sbjct: 741 PGGGMVGGGGHRPHEGPG--GGMGNSSGHRPHE----GPGGGMGS--GHRPHEGPGGSMG 792

Query: 147 GHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWG-QGGNGG-PPNF 204
           G G      G GG   G  GG G     G  G      G  P   P G  GG+GG  P+ 
Sbjct: 793 GGGGHRPHEGPGG---GISGGSGHRPHEGPGGGMGAGGGHRPHEGPGGSMGGSGGHRPHE 849

Query: 205 GTNTQGAVAQPGYGSVRA-------SNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGS 257
           G         PG+G            ++      PPP    G      GG G +    G 
Sbjct: 850 G---------PGHGGPHGHRPHDVPGHRGHDHRGPPPHEHRGHDGPGHGGGGHRGHDGGH 900

Query: 258 GSNGDNNN 265
              GD +N
Sbjct: 901 SHGGDMSN 908



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 37/128 (28%), Positives = 46/128 (35%), Gaps = 12/128 (9%)

Query: 36  GEALGHGLGDALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADAL 95
           G ++G G G    EG G  I     G +G +  E  G G    +G G    P  G   ++
Sbjct: 788 GGSMGGGGGHRPHEGPGGGIS----GGSGHRPHEGPGGG----MGAGGGHRPHEGPGGSM 839

Query: 96  GNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQG 155
           G   G   H     G   G +  DV  H     RG     P H        GHG  G +G
Sbjct: 840 GGSGGHRPHEGPGHGGPHGHRPHDVPGHRGHDHRGP----PPHEHRGHDGPGHGGGGHRG 895

Query: 156 GLGGQGQG 163
             GG   G
Sbjct: 896 HDGGHSHG 903


>gi|48762934 alpha 2 type I collagen [Homo sapiens]
          Length = 1366

 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 82/304 (26%), Positives = 105/304 (34%), Gaps = 34/304 (11%)

Query: 73  QGTREAVGT----GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAV 128
           QG R   GT    G + + G    D L  + G    A G  G E G   E+    G    
Sbjct: 162 QGARGFPGTPGLPGFKGIRGHNGLDGLKGQPG----APGVKG-EPGAPGEN----GTPGQ 212

Query: 129 RGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNP-GGLGTPWVHGYPG-----NSAG 182
            G+ +G+PG  G     G  G  GS G +G  G   P G  G P   G PG      + G
Sbjct: 213 TGA-RGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVG 271

Query: 183 SFGMNPQGAPWGQ------GGNGGPP-----NFGTNTQGAVAQPGYGSVRASNQNEGCTN 231
           + G      P G+       G  GPP     N  T  +GA   PG           G   
Sbjct: 272 NAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPG 331

Query: 232 PPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSG 291
           P  +    G+    G  G       SG+ G+  +    G        G        GS+G
Sbjct: 332 PVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAG 391

Query: 292 NSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSE 349
             G  G RG  GS    G+   +      GS G +G   G   P  +A   GE G+    
Sbjct: 392 PPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASG-PAGVRGPNGDAGRPGEPGLMGPR 450

Query: 350 TSPG 353
             PG
Sbjct: 451 GLPG 454



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 98/330 (29%), Positives = 119/330 (36%), Gaps = 53/330 (16%)

Query: 47  LSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGT-GVRQVPG-FGAADALGNR--VGEA 102
           LS  VG      A G  G+K +  L  G   A G  G R +PG  GAA A G R  VGE 
Sbjct: 290 LSGPVGPPGNPGANGLTGAKGAAGL-PGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEP 348

Query: 103 AHALGNTGHEIGRQAE--------------DVIRHGADAVRGSWQGVPGHNGAWETSGGH 148
             A G+ G E G + E              +  + G +   GS  G PG  G   + G  
Sbjct: 349 GPA-GSKG-ESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGS-AGPPGPPGLRGSPGSR 405

Query: 149 GIFGSQGGLGGQGQ-GNPGGLGTPWVHGYPGNSAGSFG----MNPQGAPWGQGGNGGPPN 203
           G+ G+ G  G  G  G+ G  G   V G P   AG  G    M P+G P G  GN GP  
Sbjct: 406 GLPGADGRAGVMGPPGSRGASGPAGVRG-PNGDAGRPGEPGLMGPRGLP-GSPGNIGP-- 461

Query: 204 FGTNTQGAVAQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSG--GGSGSQSGSSGSGSNG 261
                +G V  PG               P P G  G     G  G  G +  +   G NG
Sbjct: 462 --AGKEGPVGLPGIDG-----------RPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNG 508

Query: 262 DNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGG 319
           D  +   +G   +    G +      G  G  G  G +G  G     G    S      G
Sbjct: 509 DKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVG 568

Query: 320 SGGGNG-----HKPGCEKPGNEARGSGESG 344
             G  G       PG   P  E    GESG
Sbjct: 569 KPGERGLHGEFGLPGPAGPRGERGPPGESG 598



 Score = 65.5 bits (158), Expect = 8e-11
 Identities = 83/298 (27%), Positives = 111/298 (37%), Gaps = 27/298 (9%)

Query: 82  GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGA 141
           G R  PG   A      +G    + G  G +  +    V+     A      G+PG  GA
Sbjct: 589 GERGPPGESGAAGPTGPIGSRGPS-GPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGA 647

Query: 142 WETSGGHGIFGS---QGGLGGQGQ----GNPGGLGTPWVHGYPGN--SAGSFG----MNP 188
               GG G  G    +G +G  G+    G PG +G P   G  G+   AG+ G      P
Sbjct: 648 AGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGP 707

Query: 189 QGAPWGQGGNGGP--PNFGTNTQGAVAQPGYGSVRASNQNEGCTN-PPPSGSGGGSSNSG 245
           +G+P G+ G  GP  PN      GA  QPG    R +   +G      P+G  G +  +G
Sbjct: 708 RGSP-GERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAG 766

Query: 246 -GGSGSQSGSSGSGS-NGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSG 301
             G    +GS G G   G      ++G +     SG S      G +G  G  G RGD G
Sbjct: 767 PNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQG 826

Query: 302 SESSWGS----STGSSSGNHGGSG-GGNGHKPGCEKPGNEARGSGESGIQNSETSPGM 354
                G          +G  G SG  G    PG   P       G  G+  S    G+
Sbjct: 827 PVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGL 884



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 115/420 (27%), Positives = 150/420 (35%), Gaps = 88/420 (20%)

Query: 18   SGEAGPL-------QSGEESTGTNIGE-ALGHGLGDALSEGVGKAIGKE-AGGAAGSKVS 68
            SG AGP         SG      N GE  +   +G A   G     G+  A G  G K  
Sbjct: 597  SGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGK-G 655

Query: 69   EALGQGTREAVGT----GVRQVPGF----GAADALGNRVGEAAHA--------LGNTGH- 111
            E    G R  +G     G R  PG     G A A G+R GEA  A         G+ G  
Sbjct: 656  EKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDR-GEAGAAGPAGPAGPRGSPGER 714

Query: 112  -EIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGL-- 168
             E+G    +     A A      G  G  GA    G +G+ G  G +G  G   P G   
Sbjct: 715  GEVGPAGPNGFAGPAGAA--GQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPG 772

Query: 169  --------GTPWVHGYPGNSAGSFGMNPQG--------APWGQGGNGGP-----PNFGTN 207
                    G P + G+PG +  +    P G         P G+ G  GP     P   T 
Sbjct: 773  PAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTG 832

Query: 208  TQGAVAQPGYGSVRASNQNEGCTNPP----PSGSGGGSSNSG-GGSGSQSGSSG-SGSNG 261
              GAV  PG+   +  +   G   PP    P G  G     G  GS  + G  G +G+ G
Sbjct: 833  EVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVG 892

Query: 262  D-------NNNGSSSGGSSSGSSSGGSSGGSSG--GSSGNSG--------GSRGDSGSES 304
            +          G+     + GS     + G +G  G+ GN G        G +G+ G   
Sbjct: 893  EPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPG 952

Query: 305  SWGS-STGSSSGNHGGSG----GGNGHKPGCEKPGNEA-----RG-SGESGIQNSETSPG 353
            + G      + G HG  G     GN  + G   P   A     RG SG  GI+  +  PG
Sbjct: 953  NIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPG 1012



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 63/235 (26%), Positives = 84/235 (35%), Gaps = 23/235 (9%)

Query: 133 QGVPGHNGAWETSGGHGIFGSQGGLGGQG-------QGNPGGLGTPWVHGYPGNSA--GS 183
           +G PG +G     G  G  G QGG G QG       QG PG  G     G PG     G 
Sbjct: 519 RGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGE 578

Query: 184 FGM----NPQG--APWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPP-PSG 236
           FG+     P+G   P G+ G  GP      ++G    PG    +      G      PSG
Sbjct: 579 FGLPGPAGPRGERGPPGESGAAGPTG-PIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSG 637

Query: 237 SGG--GSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG 294
             G  G   + G  G +      G  G+  N    G   +  + G      + G  G +G
Sbjct: 638 PSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAG 697

Query: 295 --GSRGDSGSESSWG--SSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGI 345
             G  G +G   S G     G +  N      G   +PG +         GE+G+
Sbjct: 698 AAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGV 752



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 71/243 (29%), Positives = 85/243 (34%), Gaps = 28/243 (11%)

Query: 134  GVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGT---PWVHGYPGNSAGSFGM 186
            G PG  G     G  G+ GS+G  G  G     G PG LG    P   G PG + GS G+
Sbjct: 859  GTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPG-AVGSPGV 917

Query: 187  NPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTN----PPPSGSGGGSS 242
            N  GAP   G +G P N G    G   QPG+   R    N G       P P G  G + 
Sbjct: 918  N--GAPGEAGRDGNPGNDG--PPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAG 973

Query: 243  NSGG-GSGSQSGSSG-SGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG------ 294
              G  G    SG  G +G+ G        G        G        G  G++G      
Sbjct: 974  KHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPG 1033

Query: 295  --GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH--KPGCEKPGNEARGSGESGIQNSET 350
              G  GD G+  S G +         G  G +G    PG   P       G  G      
Sbjct: 1034 IAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPG 1093

Query: 351  SPG 353
             PG
Sbjct: 1094 PPG 1096



 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 55/248 (22%), Positives = 86/248 (34%), Gaps = 29/248 (11%)

Query: 134 GVPGHNGAWETS-GGHGIFGSQGGLGGQG-QGNPGGLGTPWVHGY---------PGNSAG 182
           G PG  G +     G G+    G +G  G +G PG  G P   G+         PG +  
Sbjct: 69  GPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGP 128

Query: 183 SFGMNPQGAPWGQGGNGG--------------PPNFGTNTQGAVAQPGYGSVRASNQNEG 228
           +    P G P G+ G  G               P       G    PG+  +R  N  +G
Sbjct: 129 AGARGPAGPP-GKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDG 187

Query: 229 CTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGG 288
               P +    G   + G +G+   +   G  G+     + G + +  S G        G
Sbjct: 188 LKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAG 247

Query: 289 SSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ 346
             G++G  G  G  G +   G+   +      G  G  G  PG   P       G +G+ 
Sbjct: 248 PIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVG-LPGLSGPVGPPGNPGANGLT 306

Query: 347 NSETSPGM 354
            ++ + G+
Sbjct: 307 GAKGAAGL 314



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 65/258 (25%), Positives = 78/258 (30%), Gaps = 41/258 (15%)

Query: 118 EDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYP 177
           E+ +R G    RG      G  G     G  G  G  G  G  G   P GLG  +   Y 
Sbjct: 27  EETVRKGPAGDRGP----RGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYD 82

Query: 178 GNSAGSFGMNPQG-----APWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNP 232
           G   G  G  P G      P G  G  GP  F    QG   +PG           G   P
Sbjct: 83  GKGVG-LGPGPMGLMGPRGPPGAAGAPGPQGF----QGPAGEPGEPGQTGPAGARGPAGP 137

Query: 233 PPSGSGGGSSNSGGGSGSQ-----SGSSG----------SGSNGDNNNGSSSGGSSSGSS 277
           P      G     G  G +      G+ G           G  G N      G   +   
Sbjct: 138 PGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGV 197

Query: 278 SGGSSGGSSGGSSGNSG-----------GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH 326
            G        G+ G +G           G+ G +G+  S GS          GS G  G 
Sbjct: 198 KGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGF 257

Query: 327 KPGCEKPGNEARGSGESG 344
            PG   P  E    G +G
Sbjct: 258 -PGAPGPKGEIGAVGNAG 274



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 78/283 (27%), Positives = 97/283 (34%), Gaps = 18/283 (6%)

Query: 18   SGEAGPLQSGEESTGTNIGEALGHGL-GDALSEGVGKAIGKEAGGAAGSKVSEALGQGTR 76
            +GE GP  SGE  T    G     GL G     G+  + G+         V E    G  
Sbjct: 843  AGEKGP--SGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGI- 899

Query: 77   EAVGTGVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVP 136
             A   G R  PG   +  +    GEA    GN G++ G    D  + G    RG + G  
Sbjct: 900  -AGPPGARGPPGAVGSPGVNGAPGEAGRD-GNPGND-GPPGRDG-QPGHKGERG-YPGNI 954

Query: 137  GHNGAWETSGGHGIFGSQGGLGGQGQGNPGG-LGTPWVHGYPGNSAGSFGMNPQGAPWGQ 195
            G  GA    G HG  G  G  G +G+  P G +G     G  G S        +G P  +
Sbjct: 955  GPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEK 1014

Query: 196  GGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPP-PSGSGGGSSNSG-----GGSG 249
            G  G P   G N  G    PG           G   P  P G  G S  +G     G  G
Sbjct: 1015 GPRGLPGLKGHN--GLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPG 1072

Query: 250  SQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGN 292
            +   +   G  G        G        G S GG   G  G+
Sbjct: 1073 TVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGD 1115


>gi|239754955 PREDICTED: similar to COL22A1 protein [Homo sapiens]
          Length = 1073

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 68/248 (27%), Positives = 86/248 (34%), Gaps = 21/248 (8%)

Query: 122 RHGADAVRGSW--QGVPGHNGAWETSGGHGIFGSQGGLGGQGQ----GNPGGLGTPWVHG 175
           R G +  +G     G+PG  G     G  G  G+ G +G +G     G PG +G P   G
Sbjct: 589 REGTEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPG 648

Query: 176 YPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNPPPS 235
            PG    +    P G   G  G  GPP      QG    PG          +G   PP  
Sbjct: 649 PPGADGIAGAAGPPGIQ-GSPGKEGPPG----PQGPSGLPGIPGEEGKEGRDGKPGPPGE 703

Query: 236 GSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSG- 294
               G     G  G++      G  GD+      G S +    G        G +G +G 
Sbjct: 704 PGKAGEPGLPGPEGARGPPGFKGHTGDSGAPGPRGESGAMGLPGQEGLPGKDGDTGPTGP 763

Query: 295 -------GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHK--PGCEKPGNEARGSGESGI 345
                  G  G +GS  S G    S +    GS G NG    PG   P       GE G+
Sbjct: 764 QGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPGLPGFLGPRGPPGEPGEKGV 823

Query: 346 QNSETSPG 353
              E  PG
Sbjct: 824 PGKEGVPG 831



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 68/223 (30%), Positives = 84/223 (37%), Gaps = 22/223 (9%)

Query: 124 GADAVRGSW-----QGVPGHNGAWETSGGHGIFGSQGGLGGQGQ-GNPGGLGTPWVHGYP 177
           GAD + G+      QG PG  G     G  G+ G  G  G +G+ G PG  G P   G P
Sbjct: 651 GADGIAGAAGPPGIQGSPGKEGPPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEP 710

Query: 178 GNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEGCTNP--PPS 235
           G         P G     G +G P   G +  GA+  PG   +   + + G T P  P  
Sbjct: 711 GLPGPEGARGPPGFKGHTGDSGAPGPRGES--GAMGLPGQEGLPGKDGDTGPTGPQGPQG 768

Query: 236 GSGGGSSNSGGGSGSQSGSSGS----GSNGDNNNGSSSG--GSSSGSSSGGSSG--GSSG 287
             G    N   GS  + G SG+    GS G+N +    G  G        G  G  G  G
Sbjct: 769 PRGPPGKNGSPGSPGEPGPSGTPGQKGSKGENGSPGLPGFLGPRGPPGEPGEKGVPGKEG 828

Query: 288 --GSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGH 326
             G  G  G  G RGD G +   G   G       G  G  GH
Sbjct: 829 VPGKPGEPGFKGERGDPGIKGDKGPPGGKGQPGDPGIPGHKGH 871



 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 93/378 (24%), Positives = 121/378 (32%), Gaps = 50/378 (13%)

Query: 4   QGPLACLLLALCLGSGEA-------GPLQSGEESTGTNIGEALGHGLGDALSEGVGKAIG 56
           Q PL   +L +CL    +       GP     E+       A G G    L   V     
Sbjct: 147 QAPLDREVLRVCLERSASRESLDLLGPRTDPWENVDQGAQGACGRGNTSVLPSSVAPQCS 206

Query: 57  KEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGAADALGNRV--GEAAHALGNTGHEIG 114
              G   G + S ALG            Q P    ADA  + +   + A  L     E G
Sbjct: 207 MPKG--TGHEFSAALGT-----------QGPADQRADARASCILAAKTAPGLKQLNGEPG 253

Query: 115 RQAEDVIRHGADAVRGS-----WQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLG 169
            + ED +  G   +RG        G PG  G     G  G  G +G  G QG+   G LG
Sbjct: 254 ERGEDGLP-GKPGLRGEIGEQGLAGRPGEKGEAGLPGAPGFPGVRGEKGDQGE--KGELG 310

Query: 170 TPWVHGYPGNSAGSFGMNPQGAPWGQG---------GNGGPPNFGTNTQGAVAQPGYGSV 220
            P + G  G    +    P G P             G  GP        G   +PG    
Sbjct: 311 LPGLKGDRGEKGEAGPAGPPGLPGTTSLFTPHPRMPGEQGPKG-EKGDPGLPGEPGLQGR 369

Query: 221 RASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGG 280
                 +G T PP +    G+  + G +G+       G+ G +    S G      + G 
Sbjct: 370 PGELGPQGPTGPPGAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPGSVGAPGLRGTPGK 429

Query: 281 SSGGSSGGSSGNSG-----GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGN 335
                  G++G  G     G RGD G+    G       G  G  G      PG   P  
Sbjct: 430 DGERGEKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRG-----SPGLPGPLG 484

Query: 336 EARGSGESGIQNSETSPG 353
                G  GI  S  S G
Sbjct: 485 TKGDRGAPGIPGSPGSRG 502



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 65/247 (26%), Positives = 83/247 (33%), Gaps = 43/247 (17%)

Query: 133  QGVPGHNGAWETSGGHGIFGSQGGLGGQG-QGNPGGLGTPWVHGYPGNSAGSFGMNPQGA 191
            +GVPG  G     G  G  G +G  G +G +G PGG G P   G PG+   +  M PQG 
Sbjct: 821  KGVPGKEGVPGKPGEPGFKGERGDPGIKGDKGPPGGKGQPGDPGIPGHKGHTGLMGPQGL 880

Query: 192  PWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQNEG---------------------CT 230
            P G+ G  GPP       G   QPG+  +R  + +                         
Sbjct: 881  P-GENGPVGPP-------GPPGQPGFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLA 932

Query: 231  NPPPS--GSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSG--GSS 286
              PP+   S  G     G  G       +G  G+       GG    S   G  G  G+ 
Sbjct: 933  QMPPAYMKSSQGRPGPPGPPGKDGLPGRAGPMGEPGR-PGQGGLEGPSGPIGPKGERGAK 991

Query: 287  GGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ 346
            G       G RG+ G             G  G  G      PG   P  E   +G  G+ 
Sbjct: 992  GDPGAPGVGLRGEMGPP--------GIPGQPGEPGYAKDGLPGIPGPQGETGPAGHPGLP 1043

Query: 347  NSETSPG 353
                 PG
Sbjct: 1044 GPPGPPG 1050



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 60/220 (27%), Positives = 78/220 (35%), Gaps = 26/220 (11%)

Query: 134 GVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPW 193
           G PG  G       H     + G  G+ +G+PG  G P + G PG         P GA  
Sbjct: 328 GPPGLPGTTSLFTPHPRMPGEQGPKGE-KGDPGLPGEPGLQGRPGELGPQGPTGPPGAKG 386

Query: 194 GQGGNGGPPNFGTNTQGAVAQPGY-GSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQS 252
            +G +G P        GA   PG  G V A     G + PP S    G   + G  G + 
Sbjct: 387 QEGAHGAP--------GAAGNPGAPGHVGA----PGPSGPPGSVGAPGLRGTPGKDGERG 434

Query: 253 GSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSG-----GSSGNSG--GSRGDSGSESS 305
               +G  G        G   +    G    G  G     GS G  G  G++GD G+   
Sbjct: 435 EKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSPGLPGPLGTKGDRGAPGI 494

Query: 306 WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGI 345
            G     S G+ G  G G    PG   P  +    G  G+
Sbjct: 495 PG-----SPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGL 529



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 69/263 (26%), Positives = 88/263 (33%), Gaps = 40/263 (15%)

Query: 122 RHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGGLGTPWVHGYPGN-- 179
           + G   +RGS    PG  G   T G  G  G  G  G +G    G  G P   G PG+  
Sbjct: 467 KDGEPGLRGS----PGLPGPLGTKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKG 522

Query: 180 SAGSFGM----NPQGAPWGQGGNG---------------------GPPNFG--TNTQGAV 212
           S GS G+     PQG P G+ G                       GPP        +G  
Sbjct: 523 SPGSRGLPGFPGPQG-PAGRDGLSSLLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDK 581

Query: 213 AQPGYGSVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGS 272
             PG      +   +G   PP      G +   G  G +      G  GD  +    G  
Sbjct: 582 GVPGKPGREGTEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFM 641

Query: 273 SSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGC 330
               + G        G++G  G  GS G  G     G S         G  G +G KPG 
Sbjct: 642 GPPGNPGPPGADGIAGAAGPPGIQGSPGKEGPPGPQGPSGLPGIPGEEGKEGRDG-KPG- 699

Query: 331 EKPGNEARGSGESGIQNSETSPG 353
             P  E   +GE G+   E + G
Sbjct: 700 --PPGEPGKAGEPGLPGPEGARG 720



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 84/329 (25%), Positives = 104/329 (31%), Gaps = 63/329 (19%)

Query: 82  GVRQVPGFGAADALGNRVGEAAHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGA 141
           G +  PG      L  R GE     G TG    +  E    HGA    G+  G PGH GA
Sbjct: 353 GEKGDPGLPGEPGLQGRPGELGPQ-GPTGPPGAKGQEGA--HGAPGAAGN-PGAPGHVGA 408

Query: 142 WETSGGHGIFGSQGGLGGQG-------------QGNPGGLG------TPWVHGYPGNSA- 181
              SG  G  G+ G  G  G             +G+PG +G       P + G PG    
Sbjct: 409 PGPSGPPGSVGAPGLRGTPGKDGERGEKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKD 468

Query: 182 ------GSFGM----------NPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYGSVRASNQ 225
                 GS G+             G P   G  G P        G    PG      S  
Sbjct: 469 GEPGLRGSPGLPGPLGTKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRG 528

Query: 226 NEGCTNPP-PSGSGGGSSNSGGG----------SGSQSGSSG----SGSNGDNNNGSSSG 270
             G   P  P+G  G SS    G          +    G  G     G  GD       G
Sbjct: 529 LPGFPGPQGPAGRDGLSSLLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKPG 588

Query: 271 GSSSGSSSGGSSGGSSGGSSGNSG--GSRGDSGSESSWGSSTGSSSGNHGGSG----GGN 324
              +    G +      G  G +G  GS+G+ G++   G       G+ G  G     GN
Sbjct: 589 REGTEGKKGEAGPPGLPGPPGIAGPQGSQGERGADGEVGQK--GDQGHPGVPGFMGPPGN 646

Query: 325 GHKPGCEKPGNEARGSGESGIQNSETSPG 353
              PG +     A   G  G    E  PG
Sbjct: 647 PGPPGADGIAGAAGPPGIQGSPGKEGPPG 675



 Score = 32.0 bits (71), Expect = 0.97
 Identities = 32/109 (29%), Positives = 44/109 (40%), Gaps = 21/109 (19%)

Query: 112  EIGRQAED----VIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQGQGNPGG 167
            E+G+Q E     ++     A   S QG PG  G     G  G+ G  G +G  G+   GG
Sbjct: 918  ELGKQLETRLAYLLAQMPPAYMKSSQGRPGPPGP---PGKDGLPGRAGPMGEPGRPGQGG 974

Query: 168  LGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPG 216
            L  P         +G  G  P+G    +G  G P   G   +G +  PG
Sbjct: 975  LEGP---------SGPIG--PKGERGAKGDPGAP---GVGLRGEMGPPG 1009


>gi|60593038 keratin associated protein 5-4 [Homo sapiens]
          Length = 288

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 79/227 (34%), Positives = 94/227 (41%), Gaps = 31/227 (13%)

Query: 152 GSQGGLGGQGQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGP---------- 201
           G  G  GG G G  GG G+    G  G+  G  G    G   G GG G            
Sbjct: 2   GCCGCSGGCGSGC-GGCGSGC--GGCGSGCGGCGSGCGGCGSGCGGCGSSCCVPICCCKP 58

Query: 202 -----PNFGTNTQGAV--AQPGYGSVRASNQNEGCTNPPPSGSGGGS-SNSGGGSGSQSG 253
                P    ++ G+   ++ GYGS   S    GC +   S  G GS   S GG GS  G
Sbjct: 59  VCCCVPACSCSSCGSCGGSKGGYGSCGGSKG--GCVSCGGSKGGCGSCGGSKGGCGSCGG 116

Query: 254 SSGS-GSNGDNNNGSSSGGSSSGS--SSGGSSGG--SSGGSSG---NSGGSRGDSGSESS 305
           S G  GS G +  G  S G S G   S GGS GG  S GGS G   + GGS+G  GS   
Sbjct: 117 SKGGCGSCGGSKGGCVSCGGSKGGCGSCGGSKGGCVSCGGSKGGCGSCGGSKGGCGSCGG 176

Query: 306 WGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQNSETSP 352
                GS  G+ GG G     +  C KP   + G G S  Q+S   P
Sbjct: 177 SKGGCGSCGGSKGGCGSCGCSQCSCCKPCCCSSGCGSSCCQSSCCKP 223


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.131    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,165,852
Number of Sequences: 37866
Number of extensions: 1332706
Number of successful extensions: 49062
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 941
Number of HSP's successfully gapped in prelim test: 631
Number of HSP's that attempted gapping in prelim test: 8300
Number of HSP's gapped (non-prelim): 13151
length of query: 386
length of database: 18,247,518
effective HSP length: 104
effective length of query: 282
effective length of database: 14,309,454
effective search space: 4035266028
effective search space used: 4035266028
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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