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Search of human proteins with 18677720
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
(421 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 880 0.0
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 547 e-156
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 394 e-110
gi|113865883 WD repeat domain 38 [Homo sapiens] 132 6e-31
gi|16554629 WD repeat domain 5 [Homo sapiens] 117 3e-26
gi|16554627 WD repeat domain 5 [Homo sapiens] 117 3e-26
gi|23199987 WD repeat domain 5B [Homo sapiens] 110 2e-24
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 96 5e-20
gi|26665869 WD repeat domain 51B [Homo sapiens] 96 5e-20
gi|32189425 WD repeat domain 69 [Homo sapiens] 93 4e-19
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 92 9e-19
gi|13376840 WD repeat domain 61 [Homo sapiens] 91 2e-18
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 90 4e-18
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 90 4e-18
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 90 4e-18
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 90 4e-18
gi|21071067 TBP-associated factor 5 [Homo sapiens] 89 7e-18
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 89 1e-17
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 88 2e-17
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 5e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 86 5e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 86 5e-17
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 84 3e-16
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 83 4e-16
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 82 1e-15
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 81 2e-15
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 81 2e-15
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 81 2e-15
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 81 2e-15
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 81 2e-15
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 880 bits (2275), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60
MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL
Sbjct: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60
Query: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120
VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP
Sbjct: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120
Query: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP
Sbjct: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
Query: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240
DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL
Sbjct: 181 DGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL 240
Query: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300
WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP
Sbjct: 241 WNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPP 300
Query: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS 360
PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS
Sbjct: 301 PTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFS 360
Query: 361 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR
Sbjct: 361 TDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
Query: 421 I 421
I
Sbjct: 421 I 421
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 547 bits (1410), Expect = e-156
Identities = 262/262 (100%), Positives = 262/262 (100%)
Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS
Sbjct: 14 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 73
Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR
Sbjct: 74 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 133
Query: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339
VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR
Sbjct: 134 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 193
Query: 340 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 399
IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM
Sbjct: 194 IDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVM 253
Query: 400 PTQEVQELPIPSKLLEFLSYRI 421
PTQEVQELPIPSKLLEFLSYRI
Sbjct: 254 PTQEVQELPIPSKLLEFLSYRI 275
Score = 66.2 bits (160), Expect = 5e-11
Identities = 75/295 (25%), Positives = 114/295 (38%), Gaps = 75/295 (25%)
Query: 1 MASFPPRVNEKEIVRLRTIGELLAPAAPFDKKCGRENWTVAFAPDGSYFAWSQGHRTVKL 60
MASFPPRVNEKEI G+LL + + FAPDGS S
Sbjct: 1 MASFPPRVNEKEI------GKLLLNLVDHTEVVR----DLTFAPDGSLILVS-------- 42
Query: 61 VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVP 120
+ +LR+ DG R H + V+S AF
Sbjct: 43 -----------------ASRDKTLRVWDLKDDGNMMKVLRGH----QNWVYSCAFSPD-- 79
Query: 121 EKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAP 180
+L + G + + +W++ ++ L H V F+P
Sbjct: 80 ------------------SSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSP 120
Query: 181 DGSLILVSASRDKTLRVWDLKDDGNMMK----------VLRGHQN--WVYSCAFSPDSSM 228
DG+L L +AS D + +WD + +M+ + G N WV S +FS D
Sbjct: 121 DGAL-LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 179
Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW 283
+ S+ K V W +D+ ++ + + C FS DG++LA ++D VY W
Sbjct: 180 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 232
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 394 bits (1013), Expect = e-110
Identities = 205/400 (51%), Positives = 260/400 (65%), Gaps = 12/400 (3%)
Query: 23 LAPAAP--FDKKCGRENWTVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTN 80
L P P FD K E W+VAF+PDGS+FAWSQGH VKL+PW + F+ G + +
Sbjct: 13 LKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLIPWP-LEEQFIPKGFEAKSR 71
Query: 81 SSSLRLPRQNSDGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQ 140
SS +N G + P+E +DCG IVW LAF S P SR + H
Sbjct: 72 SS------KNETKG-RGSPKEKTLDCGQIVWGLAF-SPWPSPPSRKLWARHHPQVPDVSC 123
Query: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
L+LATGLN+G+IKIW+V TG LLLNL H +VVRDL+F P GSLILVSASRDKTLR+WDL
Sbjct: 124 LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL 183
Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
G ++VL GH WVY C+ SPD SMLCS K+VFLW+M YT+IRKLEGH VV
Sbjct: 184 NKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVV 243
Query: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320
+CDFSPD ALL TASYDT V +WDP+ G+ L H P + + +RSV FS
Sbjct: 244 SCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPA-MDDSDVHISSLRSVCFS 302
Query: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWAT 380
+GL++A++ADD+++R W ++ P+ AP++NGLCC F G V+A GT DG V FW
Sbjct: 303 PEGLYLATVADDRLLRIWALELKTPIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFWTA 362
Query: 381 PRQVPSLQHLCRMSIRRVMPTQEVQELPIPSKLLEFLSYR 420
PR + SL+HLCR ++R + T +V LPIP K+ EFL+YR
Sbjct: 363 PRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 132 bits (332), Expect = 6e-31
Identities = 91/270 (33%), Positives = 134/270 (49%), Gaps = 35/270 (12%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F D +L TG +G + W+ +G+LL L HT V+ F+PDG L SAS D T+
Sbjct: 29 FSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF-ASASCDCTV 87
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
R+WD+ ++VL+GHQ V + +FSPDS L S G K V LW++ M+R L GH
Sbjct: 88 RLWDVAR-AKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGH 146
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD--------------PHNGDI---------LM 292
+ + DFSP LAT S+D+ V+IWD H+ +I L+
Sbjct: 147 RDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLL 206
Query: 293 EFG------HLFPPPTP--IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDY 344
G H++ P T + + WV+S++FS D L +AS +MV+ W +
Sbjct: 207 ASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGK 266
Query: 345 PVQV--APLSNGLCCAFSTDGSVLAAGTHD 372
++ L CAF+ DG +L +G D
Sbjct: 267 CLETLKGVLDVAHTCAFTPDGKILVSGAAD 296
Score = 86.3 bits (212), Expect = 5e-17
Identities = 64/224 (28%), Positives = 104/224 (46%), Gaps = 14/224 (6%)
Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164
DC +W +A + + ++E F D LA+G + R+ +WDV +G++L
Sbjct: 84 DCTVRLWDVARAKCLRVLKGHQRSVE--TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR 141
Query: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK--DDGNMMKVLRGHQNWVYSCAF 222
LV H + ++ F+P + L + S D T+ +WDL+ + L GH + SC
Sbjct: 142 LLVGHRDSIQSSDFSPTVNC-LATGSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCLC 199
Query: 223 SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282
S +L S K + +W +++ +L+GH V + FSPD LA+A Y V +
Sbjct: 200 YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKV 259
Query: 283 WDPHNGDIL------MEFGH--LFPPPTPIFAGGANDRWVRSVS 318
WD + G L ++ H F P I GA D+ R +S
Sbjct: 260 WDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRRQIS 303
Score = 76.3 bits (186), Expect = 5e-14
Identities = 58/186 (31%), Positives = 78/186 (41%), Gaps = 17/186 (9%)
Query: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSP 266
+K H V S AFSPD ML + V+ W ++ +L GH V C FSP
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 267 DGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLH 325
DG L A+AS D V +WD L GH R V +VSFS D
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGH--------------QRSVETVSFSPDSRQ 119
Query: 326 VASLADDKMVRFWRIDEDYPVQ--VAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQ 383
+AS DK V W + ++ V + FS + LA G+ D +V+ W
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Query: 384 VPSLQH 389
P++ H
Sbjct: 180 TPAVSH 185
Score = 75.1 bits (183), Expect = 1e-13
Identities = 67/241 (27%), Positives = 109/241 (45%), Gaps = 20/241 (8%)
Query: 42 FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99
F+PDG FA + TV+L V ++CL+ H ++V S RQ + GG +
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH-QRSVETVSFSPDSRQLASGGWDKRV 129
Query: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159
++W + G + +I+ F LATG + + IWD+
Sbjct: 130 ---------MLWDVQSGQMLRLLVGHRDSIQ--SSDFSPTVNCLATGSWDSTVHIWDLRM 178
Query: 160 GKLLLN---LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNW 216
++ L H+ + L ++ G +L S S DKT+ +W +++ L+GH W
Sbjct: 179 VTPAVSHQALEGHSANISCLCYSASG--LLASGSWDKTIHIWK-PTTSSLLIQLKGHVTW 235
Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
V S AFSPD L S G S+ V +W+ + + L+G C F+PDG +L + +
Sbjct: 236 VKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAA 295
Query: 277 D 277
D
Sbjct: 296 D 296
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 117 bits (292), Expect = 3e-26
Identities = 74/249 (29%), Positives = 121/249 (48%), Gaps = 19/249 (7%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
+F + LA+ + IKIW Y GK + H + D+ ++ D +L LVSAS DKT
Sbjct: 52 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKT 110
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
L++WD+ G +K L+GH N+V+ C F+P S+++ S ++V +W++ ++ L
Sbjct: 111 LKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169
Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
H V A F+ DG+L+ ++SYD IWD +G L PP V
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------V 217
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369
V FS +G ++ + D ++ W + ++ N C F+ T G + +G
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277
Query: 370 THDGSVYFW 378
+ D VY W
Sbjct: 278 SEDNLVYIW 286
Score = 97.8 bits (242), Expect = 2e-20
Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%)
Query: 162 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 221
L L HT+ V + F+P+G L S+S DK +++W DG K + GH+ + A
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVA 94
Query: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281
+S DS++L S K + +W++ ++ L+GH + V C+F+P L+ + S+D V
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 338
IWD G L A+ V +V F+ DG + S + D + R W
Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 339 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
ID+D P P+S FS +G + A T D ++ W
Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241
Score = 71.2 bits (173), Expect = 2e-12
Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 10/155 (6%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKT 194
F +D L+ + +G +IWD +G+ L L+D V + F+P+G IL +A+ D T
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNT 237
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIR 250
L++WD G +K GH+N Y C F+ S + S V++WN+ +++
Sbjct: 238 LKLWDYSK-GKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Query: 251 KLEGHHHDVVACDFSPDGALLATASY--DTRVYIW 283
KL+GH V++ P ++A+A+ D + +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 61.2 bits (147), Expect = 2e-09
Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
L GH V S FSP+ L S A K + +W + + GH + +S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
LL +AS D + IWD +G L GH +V +F+ + S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146
Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 380
+ D+ VR W + ++ P + A F+ DGS++ + ++DG W T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%)
Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 304
Y + L GH V + FSP+G LA++S D + IW ++G GH
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88
Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362
G +D V++S D + S +DDK ++ W + ++ + CC F+
Sbjct: 89 ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 363 GSVLAAGTHDGSVYFW 378
+++ +G+ D SV W
Sbjct: 141 SNLIVSGSFDESVRIW 156
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 117 bits (292), Expect = 3e-26
Identities = 74/249 (29%), Positives = 121/249 (48%), Gaps = 19/249 (7%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
+F + LA+ + IKIW Y GK + H + D+ ++ D +L LVSAS DKT
Sbjct: 52 KFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL-LVSASDDKT 110
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
L++WD+ G +K L+GH N+V+ C F+P S+++ S ++V +W++ ++ L
Sbjct: 111 LKIWDVSS-GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPA 169
Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
H V A F+ DG+L+ ++SYD IWD +G L PP V
Sbjct: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP------------V 217
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369
V FS +G ++ + D ++ W + ++ N C F+ T G + +G
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 277
Query: 370 THDGSVYFW 378
+ D VY W
Sbjct: 278 SEDNLVYIW 286
Score = 97.8 bits (242), Expect = 2e-20
Identities = 66/227 (29%), Positives = 105/227 (46%), Gaps = 32/227 (14%)
Query: 162 LLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCA 221
L L HT+ V + F+P+G L S+S DK +++W DG K + GH+ + A
Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEW-LASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVA 94
Query: 222 FSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281
+S DS++L S K + +W++ ++ L+GH + V C+F+P L+ + S+D V
Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW--- 338
IWD G L A+ V +V F+ DG + S + D + R W
Sbjct: 155 IWDVKTGKCLKTL-------------PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 339 -------RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
ID+D P P+S FS +G + A T D ++ W
Sbjct: 202 SGQCLKTLIDDDNP----PVS---FVKFSPNGKYILAATLDNTLKLW 241
Score = 71.2 bits (173), Expect = 2e-12
Identities = 46/155 (29%), Positives = 80/155 (51%), Gaps = 10/155 (6%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKT 194
F +D L+ + +G +IWD +G+ L L+D V + F+P+G IL +A+ D T
Sbjct: 179 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL-AATLDNT 237
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIR 250
L++WD G +K GH+N Y C F+ S + S V++WN+ +++
Sbjct: 238 LKLWDYSK-GKCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQ 295
Query: 251 KLEGHHHDVVACDFSPDGALLATASY--DTRVYIW 283
KL+GH V++ P ++A+A+ D + +W
Sbjct: 296 KLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 61.2 bits (147), Expect = 2e-09
Identities = 46/174 (26%), Positives = 72/174 (41%), Gaps = 17/174 (9%)
Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
L GH V S FSP+ L S A K + +W + + GH + +S D
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
LL +AS D + IWD +G L GH +V +F+ + S
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGH--------------SNYVFCCNFNPQSNLIVS 146
Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFWAT 380
+ D+ VR W + ++ P + A F+ DGS++ + ++DG W T
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Score = 50.8 bits (120), Expect = 2e-06
Identities = 36/136 (26%), Positives = 61/136 (44%), Gaps = 17/136 (12%)
Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPI 304
Y + L GH V + FSP+G LA++S D + IW ++G GH
Sbjct: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL------ 88
Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362
G +D V++S D + S +DDK ++ W + ++ + CC F+
Sbjct: 89 ---GISD-----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
Query: 363 GSVLAAGTHDGSVYFW 378
+++ +G+ D SV W
Sbjct: 141 SNLIVSGSFDESVRIW 156
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 110 bits (275), Expect = 2e-24
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 19/249 (7%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
+F + LA+ + I IW Y GK L H + D+ ++ D S LVSAS DKT
Sbjct: 48 KFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSR-LVSASDDKT 106
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
L++WD++ G +K L+GH N+V+ C F+P S+++ S + V +W + ++ L
Sbjct: 107 LKLWDVRS-GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSA 165
Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
H V A F+ G+L+ + SYD IWD +G L PP V
Sbjct: 166 HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPP------------V 213
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV-APLSNGLCCAFS----TDGSVLAAG 369
V FS +G ++ + D ++ W ++ N C F+ T G + +G
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSG 273
Query: 370 THDGSVYFW 378
+ D VY W
Sbjct: 274 SEDNLVYIW 282
Score = 79.0 bits (193), Expect = 8e-15
Identities = 62/241 (25%), Positives = 107/241 (44%), Gaps = 17/241 (7%)
Query: 109 IVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVD 168
I+W G EK N+E + D L + ++ +K+WDV +GK L L
Sbjct: 66 IIWGAYDGKY--EKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKG 123
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
H+ V F P +LI +S S D+T+++W++K G +K L H + V + F+ S+
Sbjct: 124 HSNYVFCCNFNPPSNLI-ISGSFDETVKIWEVK-TGKCLKTLSAHSDPVSAVHFNCSGSL 181
Query: 229 LCSVGASKAVFLWNMDKYTMIRKL-EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHN 287
+ S +W+ ++ L + + V FSP+G + TA+ D + +WD
Sbjct: 182 IVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241
Query: 288 GDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS-HDGLHVASLADDKMVRFWRIDEDYPV 346
G L + G N+++ +FS G + S ++D +V W + V
Sbjct: 242 GRCL-----------KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 290
Query: 347 Q 347
Q
Sbjct: 291 Q 291
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/149 (31%), Positives = 78/149 (52%), Gaps = 10/149 (6%)
Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEV-VRDLTFAPDGSLILVSASRDKTLRVWDL 200
L+ +G +G +IWD +G+ L LVD V + F+P+G IL +A+ D TL++WD
Sbjct: 181 LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYIL-TATLDNTLKLWDY 239
Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDS----SMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
G +K GH+N Y C F+ S + S V++WN+ +++KL+GH
Sbjct: 240 SR-GRCLKTYTGHKNEKY-CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 297
Query: 257 HDVVACDFSPDGALLATASY--DTRVYIW 283
V++ P L+A+A+ D + +W
Sbjct: 298 DVVISAACHPTENLIASAALENDKTIKLW 326
Score = 55.1 bits (131), Expect = 1e-07
Identities = 41/172 (23%), Positives = 72/172 (41%), Gaps = 17/172 (9%)
Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
L GH V S FSP+ L S A + + +W + L GH+ ++ +S D +
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
L +AS D + +WD +G L GH +V +F+ + S
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGH--------------SNYVFCCNFNPPSNLIIS 142
Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378
+ D+ V+ W + ++ + A F+ GS++ +G++DG W
Sbjct: 143 GSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 50.4 bits (119), Expect = 3e-06
Identities = 33/136 (24%), Positives = 61/136 (44%), Gaps = 17/136 (12%)
Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME-FGHLFPPPTPI 304
Y + L GH V + FSP+G LA++S D + IW ++G +GH
Sbjct: 31 YALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH-------- 82
Query: 305 FAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTD 362
+ + V++S D + S +DDK ++ W + ++ + CC F+
Sbjct: 83 ------NLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPP 136
Query: 363 GSVLAAGTHDGSVYFW 378
+++ +G+ D +V W
Sbjct: 137 SNLIISGSFDETVKIW 152
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 96.3 bits (238), Expect = 5e-20
Identities = 71/245 (28%), Positives = 112/245 (45%), Gaps = 20/245 (8%)
Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
LLATG ++ R+ +W + +++L HT V + LI V+ S+ ++RVWDL
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI-VAGSQSGSIRVWDL- 92
Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
+ +++ L GH+ + S F P + S + LW++ + + + GH V
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 320
FSPDG LA+A+ D V +WD G ++ EF GH P V V F
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP--------------VNVVEFH 198
Query: 321 HDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG-SVYF 377
+ +AS + D+ +RFW +++ V G F+ DG L +G D VY
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYG 258
Query: 378 WATPR 382
W R
Sbjct: 259 WEPER 263
Score = 89.7 bits (221), Expect = 4e-18
Identities = 63/230 (27%), Positives = 100/230 (43%), Gaps = 17/230 (7%)
Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLL 164
DC +WS+ + + +E R + L+ G +G I++WD+ K+L
Sbjct: 42 DCRVNLWSINKPNCIMSLTGHTSPVE--SVRLNTPEELIVAGSQSGSIRVWDLEAAKILR 99
Query: 165 NLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSP 224
L+ H + L F P G + S S+D +++WD++ G + + RGH V FSP
Sbjct: 100 TLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFR-YRGHSQAVRCLRFSP 157
Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
D L S V LW++ M+ + GH V +F P+ LLA+ S D + WD
Sbjct: 158 DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Query: 285 PHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKM 334
++ + P P VRSV F+ DG + S D +
Sbjct: 218 LEKFQVV---SCIEGEPGP----------VRSVLFNPDGCCLYSGCQDSL 254
Score = 34.3 bits (77), Expect = 0.22
Identities = 37/142 (26%), Positives = 52/142 (36%), Gaps = 31/142 (21%)
Query: 268 GALLATASYDTRVYIWDPHNGDILMEF-GHLFP-------PPTPIFAGGANDRWVR---- 315
G LLAT D RV +W + + +M GH P P + G+ +R
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 316 -----------------SVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGL-C 356
S+ F G VAS + D ++ W I V + S + C
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 357 CAFSTDGSVLAAGTHDGSVYFW 378
FS DG LA+ D +V W
Sbjct: 153 LRFSPDGKWLASAADDHTVKLW 174
Score = 31.2 bits (69), Expect = 1.8
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 8/91 (8%)
Query: 110 VWSLAFGSSVPEKQSRC--VNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLV 167
+W L G + E VN+ F ++ LLA+G ++ I+ WD+ +++ +
Sbjct: 173 LWDLTAGKMMSEFPGHTGPVNV----VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIE 228
Query: 168 DHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
VR + F PDG L S +D +LRV+
Sbjct: 229 GEPGPVRSVLFNPDG-CCLYSGCQD-SLRVY 257
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 96.3 bits (238), Expect = 5e-20
Identities = 68/235 (28%), Positives = 106/235 (45%), Gaps = 17/235 (7%)
Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
LAT + + +W+ V H +VV + F+P G+L L SASRD+T+R+W + D
Sbjct: 33 LATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNL-LASASRDRTVRLW-IPD 90
Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
+ H V S FS D L + K++ +W+M + + L H H V
Sbjct: 91 KRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCA 150
Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322
FSPDG L+ + S D + IWD N + F G AN V F+
Sbjct: 151 KFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD--------SVGFAN-----FVDFNPS 197
Query: 323 GLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSV 375
G +AS D+ V+ W + + +Q + +G C +F G+ L + DG++
Sbjct: 198 GTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTL 252
Score = 91.7 bits (226), Expect = 1e-18
Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 119 VPEKQSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVV 173
+P+K+ + + H F D LAT + IK+W +Y + L +L HT V
Sbjct: 88 IPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWV 147
Query: 174 RDLTFAPDGSLILVSASRDKTLRVWDL--KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCS 231
R F+PDG LI VS S DKT+++WD K N G N+V F+P + + S
Sbjct: 148 RCAKFSPDGRLI-VSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV---DFNPSGTCIAS 203
Query: 232 VGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDIL 291
G+ + V +W++ +++ + H V F P G L TAS D + I D G ++
Sbjct: 204 AGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLI 263
Query: 292 MEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDED 343
GH P V +VSFS G AS D V WR + D
Sbjct: 264 YTLQGHTGP--------------VFTVSFSKGGELFASGGADTQVLLWRTNFD 302
Score = 86.7 bits (213), Expect = 4e-17
Identities = 60/212 (28%), Positives = 92/212 (43%), Gaps = 17/212 (8%)
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
H + L +P+G L +AS D L +W+ K + + GH++ V S FSP ++
Sbjct: 17 HKAAITSLDLSPNGKQ-LATASWDTFLMLWNFKPHARAYRYV-GHKDVVTSVQFSPHGNL 74
Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNG 288
L S + V LW DK + + H V + DFS DG LATAS D + +W +
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 289 DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQV 348
L ++ + WVR FS DG + S ++DK ++ W V
Sbjct: 135 RFL-------------YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN 181
Query: 349 APLSNGLC--CAFSTDGSVLAAGTHDGSVYFW 378
S G F+ G+ +A+ D +V W
Sbjct: 182 FSDSVGFANFVDFNPSGTCIASAGSDQTVKVW 213
Score = 76.3 bits (186), Expect = 5e-14
Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 17/182 (9%)
Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
+D + + +GH+ + S SP+ L + + LWN + + GH V +
Sbjct: 6 EDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTS 65
Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFS 320
FSP G LLA+AS D V +W P EF H P VRSV FS
Sbjct: 66 VQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAP--------------VRSVDFS 111
Query: 321 HDGLHVASLADDKMVRFWRI-DEDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378
DG +A+ ++DK ++ W + + + + ++ + CA FS DG ++ + + D ++ W
Sbjct: 112 ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 379 AT 380
T
Sbjct: 172 DT 173
Score = 61.6 bits (148), Expect = 1e-09
Identities = 43/139 (30%), Positives = 64/139 (46%), Gaps = 21/139 (15%)
Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309
R +GH + + D SP+G LATAS+DT + +W+ F P +
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-------------FKPHARAYRYVG 58
Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE-----DYPVQVAPLSNGLCCAFSTDGS 364
+ V SV FS G +AS + D+ VR W D+ ++ AP+ + FS DG
Sbjct: 59 HKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRS---VDFSADGQ 115
Query: 365 VLAAGTHDGSVYFWATPRQ 383
LA + D S+ W+ RQ
Sbjct: 116 FLATASEDKSIKVWSMYRQ 134
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 93.2 bits (230), Expect = 4e-19
Identities = 85/342 (24%), Positives = 137/342 (40%), Gaps = 28/342 (8%)
Query: 40 VAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKP 99
VA GS F RT KL + + L G +NV + + N+ G K
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF-----NNPYGDKIAT 152
Query: 100 REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYT 159
C +WS+ G + I F L+ATG + K+WD+
Sbjct: 153 GSFDKTCK--LWSVETGKCYHTFRGHTAEIVC--LSFNPQSTLVATGSMDTTAKLWDIQN 208
Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
G+ + L H+ + L+F G I ++ S D T+ VWD D G + +L GH + S
Sbjct: 209 GEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVVWD-ADTGRKVNILIGHCAEISS 266
Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
+F+ D S++ + K LW+ + L GH +++ F G L+ATAS D
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGT 326
Query: 280 VYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
I+ + + GH + + +SF+ G H+ + + DK R W
Sbjct: 327 ARIFSAATRKCIAKLEGH--------------EGEISKISFNPQGNHLLTGSSDKTARIW 372
Query: 339 RIDEDYPVQV--APLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
+QV CAF+ G+++ G+ D + W
Sbjct: 373 DAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 82.0 bits (201), Expect = 9e-16
Identities = 59/230 (25%), Positives = 98/230 (42%), Gaps = 17/230 (7%)
Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
+W + G V + I F D+++ TG + + +WD TG+ + L+ H
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII--TGSFDHTVVVWDADTGRKVNILIGH 260
Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML 229
+ +F D SLIL + S DKT ++WD + G + L GH + + F ++
Sbjct: 261 CAEISSASFNWDCSLIL-TGSMDKTCKLWDATN-GKCVATLTGHDDEILDSCFDYTGKLI 318
Query: 230 CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD 289
+ A +++ I KLEGH ++ F+P G L T S D IWD G
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
Query: 290 ILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWR 339
L + G ++ + S +F++ G V + + D R WR
Sbjct: 379 CLQ-----------VLEGHTDE--IFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 76.3 bits (186), Expect = 5e-14
Identities = 60/251 (23%), Positives = 107/251 (42%), Gaps = 24/251 (9%)
Query: 145 TGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204
TG + K+WD +G+ L L H VV + F + + S DKT ++W + + G
Sbjct: 109 TGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSV-ETG 167
Query: 205 NMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF 264
RGH + +F+P S+++ + LW++ + L GH ++++ F
Sbjct: 168 KCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSF 227
Query: 265 SPDGALLATASYDTRVYIWDPHNG-DILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG 323
+ G + T S+D V +WD G + + GH + S SF+ D
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAE--------------ISSASFNWDC 273
Query: 324 LHVASLADDKMVRFWRIDEDYPVQVAPLSNG----LCCAFSTDGSVLAAGTHDGS--VYF 377
+ + + DK + W D VA L+ L F G ++A + DG+ ++
Sbjct: 274 SLILTGSMDKTCKLW--DATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Query: 378 WATPRQVPSLQ 388
AT + + L+
Sbjct: 332 AATRKCIAKLE 342
Score = 44.7 bits (104), Expect = 2e-04
Identities = 42/178 (23%), Positives = 72/178 (40%), Gaps = 20/178 (11%)
Query: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF- 264
+ KVL+ H + + A + S + + LW+ + LEGH + V A F
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFN 143
Query: 265 SPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDG 323
+P G +AT S+D +W G F GH + +SF+
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE--------------IVCLSFNPQS 189
Query: 324 LHVASLADDKMVRFWRI---DEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
VA+ + D + W I +E Y ++ + + +F+T G + G+ D +V W
Sbjct: 190 TLVATGSMDTTAKLWDIQNGEEVYTLR-GHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Score = 33.1 bits (74), Expect = 0.49
Identities = 26/135 (19%), Positives = 56/135 (41%), Gaps = 14/135 (10%)
Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIF 305
+ + + L+ H + + G+ T SYD +WD +G+ E L ++
Sbjct: 82 FYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGE---ELNTLEGHRNVVY 138
Query: 306 AGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDG 363
A N+ + G +A+ + DK + W ++ + Y + +C +F+
Sbjct: 139 AIAFNNPY---------GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQS 189
Query: 364 SVLAAGTHDGSVYFW 378
+++A G+ D + W
Sbjct: 190 TLVATGSMDTTAKLW 204
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 92.0 bits (227), Expect = 9e-19
Identities = 95/379 (25%), Positives = 147/379 (38%), Gaps = 91/379 (24%)
Query: 39 TVAFAPDGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNK 98
+VAF+P G Y A G TV+ S +F G ++ S S + G KN
Sbjct: 119 SVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKN- 177
Query: 99 PREHIIDCGDIV-WSLAFGSSVPEKQSR----CVNIEWHRFRFGQDQLLLATGLNNGRIK 153
G I+ W + G V + + W + +A+ +G ++
Sbjct: 178 --------GQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229
Query: 154 IWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGH 213
IWD G+ L HT+ V L + DG +L SAS+D+T++VW DG + + L+GH
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG--LLYSASQDRTIKVW-RAHDGVLCRTLQGH 286
Query: 214 QNWVYSCAFSPDSSM------------------------------------------LCS 231
+WV + A S D ++ L S
Sbjct: 287 GHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVS 346
Query: 232 VGASKAVFLWN--MDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD 289
+FLW+ DK + R + GH + FSPD ++A+AS+D + +WD G
Sbjct: 347 GSDDFTLFLWSPAEDKKPLTR-MTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGK 405
Query: 290 ILMEF-GHL-------FPPPTPIFAGGANDR----W-----------------VRSVSFS 320
L GH+ + + + G++D W V +V +S
Sbjct: 406 YLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWS 465
Query: 321 HDGLHVASLADDKMVRFWR 339
DG VAS DK +R WR
Sbjct: 466 PDGQRVASGGKDKCLRIWR 484
Score = 63.2 bits (152), Expect = 4e-10
Identities = 58/230 (25%), Positives = 90/230 (39%), Gaps = 42/230 (18%)
Query: 160 GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYS 219
GK L + TE V D+ + P + + +R L GH V S
Sbjct: 74 GKTLESQAVETEKVLDIIYQPQAIFRVRAVTR--------------CTSSLEGHSEAVIS 119
Query: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTR 279
AFSP L S V W++ T +GH H V++ +SPDG LA+ + +
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKLASGCKNGQ 179
Query: 280 VYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSF-----SHDGLHVASLADDKM 334
+ +WDP G + G + +W+ +S+ + + +VAS + D
Sbjct: 180 ILLWDPSTG---KQVGRTL---------AGHSKWITGLSWEPLHANPECRYVASSSKDGS 227
Query: 335 VRFW--------RIDEDYPVQVAPL---SNGLCCAFSTDGSVLAAGTHDG 373
VR W RI + V L +GL + S D ++ HDG
Sbjct: 228 VRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDG 277
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 90.9 bits (224), Expect = 2e-18
Identities = 49/149 (32%), Positives = 82/149 (55%), Gaps = 2/149 (1%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
+ D LA+G +G I I+D+ TGKLL L H +R LTF+PD L LV+AS D +
Sbjct: 156 YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL-LVTASDDGYI 214
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
+++D++ N+ L GH +WV + AF PD + S + K+V +W++ T + H
Sbjct: 215 KIYDVQH-ANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDH 273
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
V ++ +G+ + + D ++I+D
Sbjct: 274 QDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 68.6 bits (166), Expect = 1e-11
Identities = 59/260 (22%), Positives = 109/260 (41%), Gaps = 42/260 (16%)
Query: 108 DIVWSLAFGSSVPEKQSRCV----------------------NIEWHRFRFGQDQL---- 141
D +WS+A+G++ E V ++E H+ +
Sbjct: 17 DAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTL 76
Query: 142 -LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
+ A+ + I++WD+ GK + ++ L F+PD S L + + + ++ +
Sbjct: 77 PIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPD-SQYLATGTHVGKVNIFGV 135
Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
+ G L ++ S A+SPD L S + ++++ ++ LEGH +
Sbjct: 136 -ESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIR 194
Query: 261 ACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFS 320
+ FSPD LL TAS D + I+D + ++ +G A+ WV +V+F
Sbjct: 195 SLTFSPDSQLLVTASDDGYIKIYDVQHANL-----------AGTLSGHAS--WVLNVAFC 241
Query: 321 HDGLHVASLADDKMVRFWRI 340
D H S + DK V+ W +
Sbjct: 242 PDDTHFVSSSSDKSVKVWDV 261
Score = 45.8 bits (107), Expect = 7e-05
Identities = 42/181 (23%), Positives = 79/181 (43%), Gaps = 23/181 (12%)
Query: 204 GNMMKVLRGHQNWVYSCAF------SPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHH 257
G + K + H + ++S A+ + ++ + S+ V+ W ++ + LEGH
Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQL 65
Query: 258 DVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSV 317
VV+ D S + A++S D + +WD NG + G D W ++
Sbjct: 66 GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSID-----------AGPVDAW--TL 112
Query: 318 SFSHDGLHVASLADDKMVRFWRID---EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGS 374
+FS D ++A+ V + ++ ++Y + L A+S DG LA+G DG
Sbjct: 113 AFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRG-KFILSIAYSPDGKYLASGAIDGI 171
Query: 375 V 375
+
Sbjct: 172 I 172
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)
Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
G +W V F+PDGS F S +T++L + +N F + +
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 896
Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
RL N GQ + E + C + +AFG + + + +
Sbjct: 897 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 956
Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
+ WH +F D+ L + ++ I++W+ K + L H E V+D +
Sbjct: 957 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1014
Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+
Sbjct: 1015 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1071
Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
D + +L GH+ V FS D LLAT + + IW+ NG++L HL P +
Sbjct: 1072 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1127
Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
A + WV + FS DG + S +++W +
Sbjct: 1128 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1161
Score = 84.7 bits (208), Expect = 1e-16
Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 43/286 (15%)
Query: 76 KNVTNSSSLRLPRQNSDGGQK---NKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWH 132
KN+TN S L + R ++D ++ + I CG F + EK + I+ H
Sbjct: 601 KNITNLSRL-VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH 656
Query: 133 RFR-----FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDG-SLIL 186
F D +AT + ++KIW+ TG+L+ +H+E V F L+L
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 716
Query: 187 VSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW----- 241
+ S D L++WDL + + GH N V C FSPD +L S A + LW
Sbjct: 717 ATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 775
Query: 242 NMDKYTMIRK----LEGHHHD----VVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293
N K +++ LE D V C +S DGA + A+ ++++W+ + + +
Sbjct: 776 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVAD 834
Query: 294 F-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
GHL WV V FS DG + +DD+ +R W
Sbjct: 835 CRGHL--------------SWVHGVMFSPDGSSFLTSSDDQTIRLW 866
Score = 78.6 bits (192), Expect = 1e-14
Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 26/193 (13%)
Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
+W+ G V + F LLLATG ++ +K+WD+ + + H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
T V F+PD L L S S D TL++WD L+D M+V+
Sbjct: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800
Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 271
V C++S D + + V A +FLWN D + + GH V FSPDG+
Sbjct: 801 -----VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 854
Query: 272 ATASYDTRVYIWD 284
T+S D + +W+
Sbjct: 855 LTSSDDQTIRLWE 867
Score = 71.2 bits (173), Expect = 2e-12
Identities = 69/284 (24%), Positives = 118/284 (41%), Gaps = 19/284 (6%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F +D +A+ + ++++ TG+ LL + H + V F+ D I + S DK +
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKV 681
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL--WNMDKYTMIRKLE 253
++W+ G ++ H V C F+ S L S FL W++++ +
Sbjct: 682 KIWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 740
Query: 254 GHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD------ILMEFGHLFPPPTPIFAG 307
GH + V C FSPD LLA+ S D + +WD + + + F +L P +
Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--- 797
Query: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSV 365
+ V+ S+S DG + A +K+ W D V LS FS DGS
Sbjct: 798 ---EVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 853
Query: 366 LAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPI 409
+ D ++ W T + + + + + V EV L +
Sbjct: 854 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 897
Score = 67.0 bits (162), Expect = 3e-11
Identities = 59/230 (25%), Positives = 92/230 (40%), Gaps = 35/230 (15%)
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D
Sbjct: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671
Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
+ + K V +WN ++ + H V C F S LLAT S D + +WD +
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
+ FGH V FS D +AS + D ++ W +E
Sbjct: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777
Query: 343 DYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGSVYFWAT 380
+ V L CC++S DG+ + + ++ W T
Sbjct: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNT 826
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716
Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)
Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
G +W V F+PDGS F S +T++L + +N F + +
Sbjct: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939
Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
RL N GQ + E + C + +AFG + + + +
Sbjct: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999
Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
+ WH +F D+ L + ++ I++W+ K + L H E V+D +
Sbjct: 1000 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1057
Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+
Sbjct: 1058 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1114
Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
D + +L GH+ V FS D LLAT + + IW+ NG++L HL P +
Sbjct: 1115 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1170
Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
A + WV + FS DG + S +++W +
Sbjct: 1171 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1204
Score = 84.0 bits (206), Expect = 2e-16
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%)
Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
+W+ G V + F LLLATG ++ +K+WD+ + + H
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
T V F+PD L L S S D TL++WD L+D M+V+
Sbjct: 743 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 800
Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270
V C++S D + + V A +FL+++ ++ ++ GHH + CDFSP L
Sbjct: 801 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 854
Query: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
A V +W+ + + + GHL WV V FS DG +
Sbjct: 855 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 900
Query: 330 ADDKMVRFW 338
+DD+ +R W
Sbjct: 901 SDDQTIRLW 909
Score = 72.8 bits (177), Expect = 6e-13
Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181
RF D LLA+ +G +K+WD + + LNL D E +V+ +++ D
Sbjct: 750 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 809
Query: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241
G+ I+V+A + ++D+ G + ++ GH + + C FSP + + + V LW
Sbjct: 810 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 867
Query: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
N D + + GH V FSPDG+ T+S D + +W+
Sbjct: 868 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669
Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 716
Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 717 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 770
Score = 64.7 bits (156), Expect = 2e-10
Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%)
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D
Sbjct: 614 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 671
Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
+ + K V +WN ++ + H V C F S LLAT S D + +WD +
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 731
Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
+ FGH V FS D +AS + D ++ W +E
Sbjct: 732 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777
Query: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364
+ V L CC++S DG+
Sbjct: 778 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 811
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209
+I ++D++T LL + H ++ F+P L +V+ S+ + +W+ D + +
Sbjct: 820 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 877
Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
RGH +WV+ FSPD S + + + LW K
Sbjct: 878 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 913
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)
Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
G +W V F+PDGS F S +T++L + +N F + +
Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 885
Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
RL N GQ + E + C + +AFG + + + +
Sbjct: 886 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 945
Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
+ WH +F D+ L + ++ I++W+ K + L H E V+D +
Sbjct: 946 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1003
Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+
Sbjct: 1004 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1060
Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
D + +L GH+ V FS D LLAT + + IW+ NG++L HL P +
Sbjct: 1061 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1116
Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
A + WV + FS DG + S +++W +
Sbjct: 1117 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1150
Score = 84.7 bits (208), Expect = 1e-16
Identities = 79/286 (27%), Positives = 124/286 (43%), Gaps = 43/286 (15%)
Query: 76 KNVTNSSSLRLPRQNSDGGQK---NKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWH 132
KN+TN S L + R ++D ++ + I CG F + EK + I+ H
Sbjct: 590 KNITNLSRL-VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEK---LLEIKAH 645
Query: 133 RFR-----FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDG-SLIL 186
F D +AT + ++KIW+ TG+L+ +H+E V F L+L
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLL 705
Query: 187 VSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW----- 241
+ S D L++WDL + + GH N V C FSPD +L S A + LW
Sbjct: 706 ATGSSDCFLKLWDL-NQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA 764
Query: 242 NMDKYTMIRK----LEGHHHD----VVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293
N K +++ LE D V C +S DGA + A+ ++++W+ + + +
Sbjct: 765 NERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLWNTDSRSKVAD 823
Query: 294 F-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
GHL WV V FS DG + +DD+ +R W
Sbjct: 824 CRGHL--------------SWVHGVMFSPDGSSFLTSSDDQTIRLW 855
Score = 78.6 bits (192), Expect = 1e-14
Identities = 55/193 (28%), Positives = 83/193 (43%), Gaps = 26/193 (13%)
Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
+W+ G V + F LLLATG ++ +K+WD+ + + H
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
T V F+PD L L S S D TL++WD L+D M+V+
Sbjct: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789
Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALL 271
V C++S D + + V A +FLWN D + + GH V FSPDG+
Sbjct: 790 -----VKCCSWSADGARIM-VAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 843
Query: 272 ATASYDTRVYIWD 284
T+S D + +W+
Sbjct: 844 LTSSDDQTIRLWE 856
Score = 71.2 bits (173), Expect = 2e-12
Identities = 69/284 (24%), Positives = 118/284 (41%), Gaps = 19/284 (6%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F +D +A+ + ++++ TG+ LL + H + V F+ D I + S DK +
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFI-ATCSVDKKV 670
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFL--WNMDKYTMIRKLE 253
++W+ G ++ H V C F+ S L S FL W++++ +
Sbjct: 671 KIWNSMT-GELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 729
Query: 254 GHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGD------ILMEFGHLFPPPTPIFAG 307
GH + V C FSPD LLA+ S D + +WD + + + F +L P +
Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM--- 786
Query: 308 GANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAP--LSNGLCCAFSTDGSV 365
+ V+ S+S DG + A +K+ W D V LS FS DGS
Sbjct: 787 ---EVIVKCCSWSADGARIMVAAKNKIF-LWNTDSRSKVADCRGHLSWVHGVMFSPDGSS 842
Query: 366 LAAGTHDGSVYFWATPRQVPSLQHLCRMSIRRVMPTQEVQELPI 409
+ D ++ W T + + + + + V EV L +
Sbjct: 843 FLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAV 886
Score = 67.0 bits (162), Expect = 3e-11
Identities = 59/230 (25%), Positives = 92/230 (40%), Gaps = 35/230 (15%)
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D
Sbjct: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
+ + K V +WN ++ + H V C F S LLAT S D + +WD +
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
+ FGH V FS D +AS + D ++ W +E
Sbjct: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
Query: 343 DYPVQVAPLSNGL------------CCAFSTDGSVLAAGTHDGSVYFWAT 380
+ V L CC++S DG+ + + ++ W T
Sbjct: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNT 815
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705
Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 89.7 bits (221), Expect = 4e-18
Identities = 87/337 (25%), Positives = 141/337 (41%), Gaps = 42/337 (12%)
Query: 34 GRENWT--VAFAPDGSYFAWSQGHRTVKLVPWSQCLQN------------FLLHGTKNVT 79
G +W V F+PDGS F S +T++L + +N F + +
Sbjct: 869 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 928
Query: 80 NSSSLRLPRQNSDGGQKNKPREHIIDC---GDIVWSLAFG-------------SSVPEKQ 123
RL N GQ + E + C + +AFG + + + +
Sbjct: 929 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 988
Query: 124 SRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGS 183
+ WH +F D+ L + ++ I++W+ K + L H E V+D +
Sbjct: 989 FQHKKTVWH-IQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSR 1046
Query: 184 LILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
L+ S S D T++VW++ GN K HQ V SC S D++ S A K +W+
Sbjct: 1047 LL--SWSFDGTVKVWNI-ITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSF 1103
Query: 244 DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTP 303
D + +L GH+ V FS D LLAT + + IW+ NG++L HL P +
Sbjct: 1104 DLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL----HLCAPLSE 1159
Query: 304 IFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340
A + WV + FS DG + S +++W +
Sbjct: 1160 EGA-ATHGGWVTDLCFSPDGKMLISAGG--YIKWWNV 1193
Score = 84.0 bits (206), Expect = 2e-16
Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 42/249 (16%)
Query: 110 VWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDH 169
+W+ G V + F LLLATG ++ +K+WD+ + + H
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 170 TEVVRDLTFAPDGSLILVSASRDKTLRVWD------------------LKDDGNMMKVLR 211
T V F+PD L L S S D TL++WD L+D M+V+
Sbjct: 732 TNSVNHCRFSPDDKL-LASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI- 789
Query: 212 GHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE-GHHHDVVACDFSPDGAL 270
V C++S D + + V A +FL+++ ++ ++ GHH + CDFSP L
Sbjct: 790 -----VKCCSWSADGARI-MVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 843
Query: 271 LATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
A V +W+ + + + GHL WV V FS DG +
Sbjct: 844 AVVALSQYCVELWNTDSRSKVADCRGHL--------------SWVHGVMFSPDGSSFLTS 889
Query: 330 ADDKMVRFW 338
+DD+ +R W
Sbjct: 890 SDDQTIRLW 898
Score = 72.8 bits (177), Expect = 6e-13
Identities = 46/163 (28%), Positives = 79/163 (48%), Gaps = 15/163 (9%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTG---------KLLLNLVDHTE----VVRDLTFAPD 181
RF D LLA+ +G +K+WD + + LNL D E +V+ +++ D
Sbjct: 739 RFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSAD 798
Query: 182 GSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLW 241
G+ I+V+A + ++D+ G + ++ GH + + C FSP + + + V LW
Sbjct: 799 GARIMVAAKNK--IFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELW 856
Query: 242 NMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
N D + + GH V FSPDG+ T+S D + +W+
Sbjct: 857 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
Score = 65.5 bits (158), Expect = 9e-11
Identities = 42/174 (24%), Positives = 79/174 (45%), Gaps = 17/174 (9%)
Query: 209 VLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDG 268
V+R H + VY FS D + S GA K + ++ + + +++ H +V+ C FS D
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658
Query: 269 ALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLH--V 326
+AT S D +V IW+ G+++ + + V F++ H +
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDE-------------HSEQVNCCHFTNSSHHLLL 705
Query: 327 ASLADDKMVRFWRID--EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
A+ + D ++ W ++ E ++ C FS D +LA+ + DG++ W
Sbjct: 706 ATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 759
Score = 64.7 bits (156), Expect = 2e-10
Identities = 57/214 (26%), Positives = 86/214 (40%), Gaps = 34/214 (15%)
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
HT+ V F+ DG I S DKTL+V+ + G + ++ H++ V CAFS D
Sbjct: 603 HTDAVYHACFSEDGQRI-ASCGADKTLQVFKA-ETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 229 LCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDF--SPDGALLATASYDTRVYIWDPH 286
+ + K V +WN ++ + H V C F S LLAT S D + +WD +
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLN 720
Query: 287 NGDIL-MEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---RIDE 342
+ FGH V FS D +AS + D ++ W +E
Sbjct: 721 QKECRNTMFGH--------------TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
Query: 343 DYPVQVAPLSNGL------------CCAFSTDGS 364
+ V L CC++S DG+
Sbjct: 767 RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGA 800
Score = 44.7 bits (104), Expect = 2e-04
Identities = 26/96 (27%), Positives = 48/96 (50%), Gaps = 3/96 (3%)
Query: 151 RIKIWDVYTGKLLLNL-VDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKV 209
+I ++D++T LL + H ++ F+P L +V+ S+ + +W+ D + +
Sbjct: 809 KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ-YCVELWNT-DSRSKVAD 866
Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
RGH +WV+ FSPD S + + + LW K
Sbjct: 867 CRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKK 902
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 89.0 bits (219), Expect = 7e-18
Identities = 78/271 (28%), Positives = 114/271 (42%), Gaps = 44/271 (16%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D L+A G + +++W V KL R + A D SLI S D R+
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKL-----------RSVKQASDLSLI-DKESDDVLERIM 528
Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
D K + +K+L GH VY +FSPD + L S V LW++ +T + +GH++
Sbjct: 529 DEKT-ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYP 587
Query: 259 VVACDFSPDGALLATASYDTRVYIW-DPHNGDILMEFGHL-------FPPPTPIFAGGAN 310
V FSP G + +D +W H + + GHL F P + A G+
Sbjct: 588 VWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSA 647
Query: 311 DRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVA 349
DR VR S++FS +G +A+ A D V W I V
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707
Query: 350 PLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378
C+ FS DG +LA+G+ D +V W
Sbjct: 708 KGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 85.5 bits (210), Expect = 8e-17
Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 17/204 (8%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F D+ L + +G +++W + T L+ H V D F+P G VS D+
Sbjct: 551 FSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYG-YYFVSGGHDRVA 609
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
R+W D +++ GH V F P+S+ + + A + V LW++ +R GH
Sbjct: 610 RLW-ATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGH 668
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
+ + FSP+G LAT + D RV +WD +G ++ E GH V
Sbjct: 669 KGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH--------------TDTV 714
Query: 315 RSVSFSHDGLHVASLADDKMVRFW 338
S+ FS DG +AS + D VR W
Sbjct: 715 CSLRFSRDGEILASGSMDNTVRLW 738
Score = 60.1 bits (144), Expect = 4e-09
Identities = 35/111 (31%), Positives = 55/111 (49%), Gaps = 2/111 (1%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
RF + +ATG + +++WDV G + H + LTF+P+G + A+ +
Sbjct: 634 RFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDK 245
L +WD+ G M+ L+GH + V S FS D +L S V LW+ K
Sbjct: 694 L-LWDI-GHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 56.2 bits (134), Expect = 5e-08
Identities = 28/68 (41%), Positives = 39/68 (57%), Gaps = 1/68 (1%)
Query: 132 HRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASR 191
H F + LATG +GR+ +WD+ G ++ L HT+ V L F+ DG IL S S
Sbjct: 673 HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE-ILASGSM 731
Query: 192 DKTLRVWD 199
D T+R+WD
Sbjct: 732 DNTVRLWD 739
Score = 30.8 bits (68), Expect = 2.4
Identities = 39/170 (22%), Positives = 57/170 (33%), Gaps = 44/170 (25%)
Query: 246 YTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIW-------------------DPH 286
YT + +G + A D + D +L+A D+ V +W D
Sbjct: 464 YTFLNAYQG----LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKE 519
Query: 287 NGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID---- 341
+ D+L I G + V SFS D ++ S ++D VR W +
Sbjct: 520 SDDVLERIMDEKTASELKILYGHSGP--VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTC 577
Query: 342 ------EDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFWATPRQVP 385
+YPV FS G +G HD WAT P
Sbjct: 578 LVGYKGHNYPVWDTQ--------FSPYGYYFVSGGHDRVARLWATDHYQP 619
Score = 30.4 bits (67), Expect = 3.1
Identities = 34/160 (21%), Positives = 61/160 (38%), Gaps = 18/160 (11%)
Query: 42 FAPDGSYFAWSQGHRTVKL--VPWSQCLQNFLLHG--TKNVTNSSSLRLPRQNSDGGQKN 97
F P+ +Y A RTV+L V C++ F H ++T S + R + G+
Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRV- 693
Query: 98 KPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDV 157
++W + G V E + + RF +D +LA+G + +++WD
Sbjct: 694 -----------LLWDIGHGLMVGELKGHTDTV--CSLRFSRDGEILASGSMDNTVRLWDA 740
Query: 158 YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRV 197
L D T + + +L+ K+ V
Sbjct: 741 IKAFEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPV 780
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 88.6 bits (218), Expect = 1e-17
Identities = 54/174 (31%), Positives = 84/174 (48%), Gaps = 17/174 (9%)
Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPD 225
L H V + F P S ++VSAS D T++VWD + G+ + L+GH + V +F
Sbjct: 104 LSGHRSPVTRVIFHPVFS-VMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHS 161
Query: 226 SSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDP 285
+L S A + LW+ + IR + GH H+V + P+G + +AS D + +W+
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221
Query: 286 HNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
G + F GH WVR V + DG +AS ++D+ VR W
Sbjct: 222 QTGYCVKTFTGH--------------REWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 85.1 bits (209), Expect = 1e-16
Identities = 62/224 (27%), Positives = 94/224 (41%), Gaps = 37/224 (16%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F LLA+ + IK+WD + + + H V + P+G I VSASRDKT+
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHI-VSASRDKTI 216
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
++W+++ G +K GH+ WV + D +++ S + V +W + +L H
Sbjct: 217 KMWEVQT-GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREH 275
Query: 256 HHDVVACDFSPD--------------------GALLATASYDTRVYIWDPHNGDILMEF- 294
H V ++P+ G L + S D + +WD G LM
Sbjct: 276 EHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335
Query: 295 GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW 338
GH D WVR V F G + S ADDK +R W
Sbjct: 336 GH--------------DNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 83.2 bits (204), Expect = 4e-16
Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 21/175 (12%)
Query: 130 EWHRF-RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSL---- 184
EW R R QD L+A+ N+ +++W V T + L +H VV +++AP+ S
Sbjct: 235 EWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSIS 294
Query: 185 ---------------ILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSML 229
L+S SRDKT+++WD+ G + L GH NWV F +
Sbjct: 295 EATGSETKKSGKPGPFLLSGSRDKTIKMWDVST-GMCLMTLVGHDNWVRGVLFHSGGKFI 353
Query: 230 CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
S K + +W+ ++ L H H V + DF + T S D V +W+
Sbjct: 354 LSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 59.3 bits (142), Expect = 6e-09
Identities = 43/172 (25%), Positives = 73/172 (42%), Gaps = 17/172 (9%)
Query: 210 LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
L GH++ V F P S++ S + +W+ + R L+GH V F G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 270 LLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVAS 328
LLA+ S D + +WD + + GH D V SV+ +G H+ S
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGH--------------DHNVSSVAIMPNGDHIVS 209
Query: 329 LADDKMVRFWRIDEDYPVQVAPLSNGLCCAF--STDGSVLAAGTHDGSVYFW 378
+ DK ++ W + Y V+ + DG+++A+ ++D +V W
Sbjct: 210 ASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 58.5 bits (140), Expect = 1e-08
Identities = 50/207 (24%), Positives = 85/207 (41%), Gaps = 35/207 (16%)
Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR 211
IK+W+V TG + H E VR + DG+LI S S D+T+RVW + LR
Sbjct: 216 IKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLI-ASCSNDQTVRVWVVATK-ECKAELR 273
Query: 212 GHQNWVYSCAFSPDSS--------------------MLCSVGASKAVFLWNMDKYTMIRK 251
H++ V +++P+SS L S K + +W++ +
Sbjct: 274 EHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMT 333
Query: 252 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 311
L GH + V F G + + + D + +WD N + A++
Sbjct: 334 LVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL-------------NAHE 380
Query: 312 RWVRSVSFSHDGLHVASLADDKMVRFW 338
+V S+ F +V + + D+ V+ W
Sbjct: 381 HFVTSLDFHKTAPYVVTGSVDQTVKVW 407
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 87.8 bits (216), Expect = 2e-17
Identities = 48/147 (32%), Positives = 78/147 (53%), Gaps = 2/147 (1%)
Query: 141 LLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
L A+G ++ ++W L H V + F P+ + L + S DKT+R+W
Sbjct: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY-LATGSTDKTVRLWSA 455
Query: 201 KDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV 260
+ GN +++ GH+ V S AFSP+ L S G + + LW++ T+ ++L GH ++
Sbjct: 456 QQ-GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 261 ACDFSPDGALLATASYDTRVYIWDPHN 287
+ FSPD L+A+AS D V +WD N
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 83.2 bits (204), Expect = 4e-16
Identities = 75/273 (27%), Positives = 111/273 (40%), Gaps = 47/273 (17%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D LLA G +N IK+W + + KL H V + A D L
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD------------ILEEE 324
Query: 199 DLKDD--GNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
D +DD G MK+LRGH VYS F DSS L S ++ W++ +T +GH
Sbjct: 325 DDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384
Query: 257 HDVVACDFSPDGALLATASYDTRVYIWD-PHNGDILMEFGHL-------FPPPTPIFAGG 308
+ V D SP A+ S+D +W + + GHL F P + A G
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATG 444
Query: 309 ANDRWVR---------------------SVSFSHDGLHVASLADDKMVRFWRIDED--YP 345
+ D+ VR S++FS +G ++AS +D+ ++ W + Y
Sbjct: 445 STDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYK 504
Query: 346 VQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
N FS D ++A+ + D SV W
Sbjct: 505 ELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 83.2 bits (204), Expect = 4e-16
Identities = 63/210 (30%), Positives = 94/210 (44%), Gaps = 15/210 (7%)
Query: 135 RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKT 194
RF D L + + I+ WD+ + + H V DL +P SL S S D+T
Sbjct: 349 RFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY-SLYFASGSHDRT 407
Query: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
R+W D +++ GH V F P+S+ L + K V LW+ + +R G
Sbjct: 408 ARLWSF-DRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTG 466
Query: 255 HHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWV 314
H V++ FSP+G LA+A D R+ +WD +G + E G D +
Sbjct: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL------------RGHTDN-I 513
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDEDY 344
S++FS D +AS + D VR W I Y
Sbjct: 514 TSLTFSPDSGLIASASMDNSVRVWDIRNTY 543
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 86.3 bits (212), Expect = 5e-17
Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F D T ++ +K+W + K L +L H VR F+PDG LI VSAS DKT+
Sbjct: 73 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 131
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
++WD K + H +V F P + + + G V +W++ + +++ + H
Sbjct: 132 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
V F P G L TAS D+ + I D G +L GH P T
Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 238
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343
V+FS G + AS D+ V W+ + D
Sbjct: 239 --VAFSRTGEYFASGGSDEQVMVWKSNFD 265
Score = 82.0 bits (201), Expect = 9e-16
Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%)
Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177
QSR H+ F LLA+G + ++IW HT VR +
Sbjct: 13 QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 72
Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237
F DG V+AS DKT++VW + L H NWV FSPD ++ S K
Sbjct: 73 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 130
Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
V LW+ + H V DF P G +A A D V +WD +L +
Sbjct: 131 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 187
Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355
+ V +SF G ++ + + D ++ + E + G
Sbjct: 188 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378
AFS G A+G D V W
Sbjct: 238 TVAFSRTGEYFASGGSDEQVMVW 260
Score = 60.8 bits (146), Expect = 2e-09
Identities = 42/143 (29%), Positives = 66/143 (46%), Gaps = 15/143 (10%)
Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
+ +W+M + + GH V +FSP G LLA+ S D V IW P+
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPN----------- 53
Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLC 356
+ +F A+ VRSV F DG + +DDK V+ W + + ++ N +
Sbjct: 54 VKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR 111
Query: 357 CA-FSTDGSVLAAGTHDGSVYFW 378
CA FS DG ++ + + D +V W
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLW 134
Score = 33.9 bits (76), Expect = 0.28
Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 2/72 (2%)
Query: 314 VRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTH 371
V V+FS G +AS + DK VR W + + V A + F +DG +
Sbjct: 26 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 85
Query: 372 DGSVYFWATPRQ 383
D +V WAT RQ
Sbjct: 86 DKTVKVWATHRQ 97
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 86.3 bits (212), Expect = 5e-17
Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F D T ++ +K+W + K L +L H VR F+PDG LI VSAS DKT+
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 169
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
++WD K + H +V F P + + + G V +W++ + +++ + H
Sbjct: 170 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
V F P G L TAS D+ + I D G +L GH P T
Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 276
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343
V+FS G + AS D+ V W+ + D
Sbjct: 277 --VAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 82.0 bits (201), Expect = 9e-16
Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%)
Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177
QSR H+ F LLA+G + ++IW HT VR +
Sbjct: 51 QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 110
Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237
F DG V+AS DKT++VW + L H NWV FSPD ++ S K
Sbjct: 111 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 168
Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
V LW+ + H V DF P G +A A D V +WD +L +
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 225
Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355
+ V +SF G ++ + + D ++ + E + G
Sbjct: 226 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378
AFS G A+G D V W
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVW 298
Score = 78.6 bits (192), Expect = 1e-14
Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 23/238 (9%)
Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
LA+G + + +W + H + V + F+P G L L S SRDKT+R+W
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92
Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
G V R H V S F D + K V +W + + L H + V
Sbjct: 93 KGE-STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151
Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322
FSPDG L+ +AS D V +WD + + + + GG +V V F
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---------HGG----FVTYVDFHPS 198
Query: 323 GLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
G +A+ D V+ W R+ + Y + A + NGL +F G+ L + D ++
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253
Score = 73.2 bits (178), Expect = 4e-13
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)
Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
+D ++ + +GH++ V FS ++ L S + +W+M + + GH V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
+FSP G LLA+ S D V IW P+ + +F A+ VRSV F
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113
Query: 322 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378
DG + +DDK V+ W + + ++ N + CA FS DG ++ + + D +V W
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 47.0 bits (110), Expect = 3e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%)
Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309
R +GH V DFS + LA+ S D+ + +W H+ P G
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60
Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 367
D V V+FS G +AS + DK VR W + + V A + F +DG
Sbjct: 61 KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 368 AGTHDGSVYFWATPRQ 383
+ D +V WAT RQ
Sbjct: 120 TASDDKTVKVWATHRQ 135
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 86.3 bits (212), Expect = 5e-17
Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 17/209 (8%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F D T ++ +K+W + K L +L H VR F+PDG LI VSAS DKT+
Sbjct: 111 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLI-VSASDDKTV 169
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
++WD K + H +V F P + + + G V +W++ + +++ + H
Sbjct: 170 KLWD-KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 228
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWV 314
V F P G L TAS D+ + I D G +L GH P T
Sbjct: 229 SAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATT------------ 276
Query: 315 RSVSFSHDGLHVASLADDKMVRFWRIDED 343
V+FS G + AS D+ V W+ + D
Sbjct: 277 --VAFSRTGEYFASGGSDEQVMVWKSNFD 303
Score = 82.0 bits (201), Expect = 9e-16
Identities = 69/263 (26%), Positives = 98/263 (37%), Gaps = 22/263 (8%)
Query: 123 QSRCVNIEWHR-----FRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLT 177
QSR H+ F LLA+G + ++IW HT VR +
Sbjct: 51 QSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH 110
Query: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKA 237
F DG V+AS DKT++VW + L H NWV FSPD ++ S K
Sbjct: 111 FCSDGQSF-VTASDDKTVKVWATHRQKFLFS-LSQHINWVRCAKFSPDGRLIVSASDDKT 168
Query: 238 VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHL 297
V LW+ + H V DF P G +A A D V +WD +L +
Sbjct: 169 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY--- 225
Query: 298 FPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--L 355
+ V +SF G ++ + + D ++ + E + G
Sbjct: 226 ----------QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 275
Query: 356 CCAFSTDGSVLAAGTHDGSVYFW 378
AFS G A+G D V W
Sbjct: 276 TVAFSRTGEYFASGGSDEQVMVW 298
Score = 78.6 bits (192), Expect = 1e-14
Identities = 65/238 (27%), Positives = 100/238 (42%), Gaps = 23/238 (9%)
Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
LA+G + + +W + H + V + F+P G L L S SRDKT+R+W
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL-LASGSRDKTVRIWVPNV 92
Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
G V R H V S F D + K V +W + + L H + V
Sbjct: 93 KGE-STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCA 151
Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322
FSPDG L+ +AS D V +WD + + + + GG +V V F
Sbjct: 152 KFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE---------HGG----FVTYVDFHPS 198
Query: 323 GLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
G +A+ D V+ W R+ + Y + A + NGL +F G+ L + D ++
Sbjct: 199 GTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV-NGL--SFHPSGNYLITASSDSTL 253
Score = 73.2 bits (178), Expect = 4e-13
Identities = 50/179 (27%), Positives = 83/179 (46%), Gaps = 15/179 (8%)
Query: 202 DDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVA 261
+D ++ + +GH++ V FS ++ L S + +W+M + + GH V
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 262 CDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSH 321
+FSP G LLA+ S D V IW P+ + +F A+ VRSV F
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPN-----------VKGESTVFR--AHTATVRSVHFCS 113
Query: 322 DGLHVASLADDKMVRFWRID-EDYPVQVAPLSNGLCCA-FSTDGSVLAAGTHDGSVYFW 378
DG + +DDK V+ W + + ++ N + CA FS DG ++ + + D +V W
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172
Score = 47.0 bits (110), Expect = 3e-05
Identities = 40/136 (29%), Positives = 56/136 (41%), Gaps = 15/136 (11%)
Query: 250 RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGA 309
R +GH V DFS + LA+ S D+ + +W H+ P G
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW------------HMKPQSRAYRFTGH 60
Query: 310 NDRWVRSVSFSHDGLHVASLADDKMVRFW--RIDEDYPVQVAPLSNGLCCAFSTDGSVLA 367
D V V+FS G +AS + DK VR W + + V A + F +DG
Sbjct: 61 KDA-VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 368 AGTHDGSVYFWATPRQ 383
+ D +V WAT RQ
Sbjct: 120 TASDDKTVKVWATHRQ 135
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 83.6 bits (205), Expect = 3e-16
Identities = 71/241 (29%), Positives = 109/241 (45%), Gaps = 28/241 (11%)
Query: 152 IKIWDVYTG-KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVL 210
I +W+VY L H+ V +L + DGS+ L SAS DKT+ VWD + G +K L
Sbjct: 90 ILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM-LFSASTDKTVAVWD-SETGERVKRL 147
Query: 211 RGHQNWVYSCAFSPDSSMLCSVGASKA-VFLWNMDKYTMIRKLEGHHHDVVACDFSPDGA 269
+GH ++V SC + L G+ V LW++ K I+ + + + V+A F+
Sbjct: 148 KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSD 206
Query: 270 LLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASL 329
+ + D + +WD + T G A+ V +S S +G ++ S
Sbjct: 207 QIISGGIDNDIKVWDLRQNKL-----------TYTMRGHADS--VTGLSLSSEGSYLLSN 253
Query: 330 ADDKMVRFWRIDEDYPVQVAPL----------SNGLCCAFSTDGSVLAAGTHDGSVYFWA 379
A D VR W + P + N L C++S DGS +AAG+ D VY W
Sbjct: 254 AMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
Query: 380 T 380
T
Sbjct: 314 T 314
Score = 77.4 bits (189), Expect = 2e-14
Identities = 43/148 (29%), Positives = 81/148 (54%), Gaps = 9/148 (6%)
Query: 142 LLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLK 201
+++ G++N IK+WD+ KL + H + V L+ + +GS +L +A D T+RVWD++
Sbjct: 208 IISGGIDND-IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM-DNTVRVWDVR 265
Query: 202 DDGNMMKVLRGHQNWVYS-------CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254
+ ++ Q V++ C++SPD S + + A + V++W+ ++ KL G
Sbjct: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325
Query: 255 HHHDVVACDFSPDGALLATASYDTRVYI 282
H + F PD ++ +AS D R+Y+
Sbjct: 326 HAGSINEVAFHPDEPIIISASSDKRLYM 353
Score = 67.8 bits (164), Expect = 2e-11
Identities = 55/251 (21%), Positives = 104/251 (41%), Gaps = 25/251 (9%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
+ D +L + + + +WD TG+ + L HT V A G ++ + S D T+
Sbjct: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
++WD++ + +Q V + F+ S + S G + +W++ + + + GH
Sbjct: 177 KLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP---TPIFAGGAN-- 310
V S +G+ L + + D V +WD F P IF G +
Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP----------FAPKERCVKIFQGNVHNF 284
Query: 311 DRWVRSVSFSHDGLHVASLADDKMVRFW-----RIDEDYPVQVAPLSNGLCCAFSTDGSV 365
++ + S+S DG +A+ + D+ V W RI P ++ AF D +
Sbjct: 285 EKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINE---VAFHPDEPI 341
Query: 366 LAAGTHDGSVY 376
+ + + D +Y
Sbjct: 342 IISASSDKRLY 352
Score = 35.4 bits (80), Expect = 0.098
Identities = 19/69 (27%), Positives = 36/69 (52%), Gaps = 1/69 (1%)
Query: 133 RFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRD 192
R + D +A G + + +WD + ++L L H + ++ F PD I++SAS D
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD-EPIIISASSD 348
Query: 193 KTLRVWDLK 201
K L + +++
Sbjct: 349 KRLYMGEIQ 357
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 83.2 bits (204), Expect = 4e-16
Identities = 65/256 (25%), Positives = 110/256 (42%), Gaps = 22/256 (8%)
Query: 132 HRFRFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASR 191
+ +G D LL + +G++ IWD YT + + + V +AP G+ +
Sbjct: 59 YAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYV-ACGGL 117
Query: 192 DKTLRVWDLKD-DGN--MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTM 248
D +++LK +GN + + L GH ++ C F DS ++ S G + LW+++
Sbjct: 118 DNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCA-LWDIETAQQ 176
Query: 249 IRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGG 308
GH DV++ SPD + + D +WD +G F G
Sbjct: 177 TTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQS-----------FTGH 225
Query: 309 ANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLC----CAFSTDGS 364
+D + +VSF +G A+ +DD R + + D + + N +C AFS G
Sbjct: 226 VSD--INAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGR 283
Query: 365 VLAAGTHDGSVYFWAT 380
+L AG D + W T
Sbjct: 284 LLLAGYDDFNCNVWDT 299
Score = 55.1 bits (131), Expect = 1e-07
Identities = 39/149 (26%), Positives = 66/149 (44%), Gaps = 6/149 (4%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D +G + K+WD+ G + H + ++F P+G + S D T R++
Sbjct: 195 DMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNG-YAFATGSDDATCRLF 253
Query: 199 DLKDDGNMMKVLRGHQN---WVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
DL+ D ++ L H N + S AFS +L + +W+ K L GH
Sbjct: 254 DLRADQELL--LYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGH 311
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWD 284
+ V + DG +AT S+D+ + IW+
Sbjct: 312 DNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 37.7 bits (86), Expect = 0.020
Identities = 34/141 (24%), Positives = 54/141 (38%), Gaps = 30/141 (21%)
Query: 242 NMDKYTMI-----RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGH 296
NMD I R L GH + A + D LL +AS D ++ IWD + + + H
Sbjct: 36 NMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKM----H 91
Query: 297 LFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFW---------RIDEDYPVQ 347
P WV + +++ G +VA D + + R+ + P
Sbjct: 92 AIP---------LRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGH 142
Query: 348 VAPLSNGLCCAFSTDGSVLAA 368
LS CC F D ++ +
Sbjct: 143 TGYLS---CCRFLDDSQIVTS 160
Score = 29.6 bits (65), Expect = 5.4
Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 1/64 (1%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F + LL G ++ +WD G L H V L DG + + + S D L
Sbjct: 278 FSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDG-MAVATGSWDSFL 336
Query: 196 RVWD 199
R+W+
Sbjct: 337 RIWN 340
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 81.6 bits (200), Expect = 1e-15
Identities = 48/158 (30%), Positives = 82/158 (51%), Gaps = 2/158 (1%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
+ +Q LLA L + +KI+ V T K L+L H V + + DG+LI + S D+ +
Sbjct: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI-ATGSADRNV 615
Query: 196 RVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
++W L D G+ K L H + V F P S + + G + W+ DK+ I+ LEGH
Sbjct: 616 KIWGL-DFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGH 674
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILME 293
H ++ SP G + ++S+D + +W+ +++E
Sbjct: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILE 712
Score = 72.8 bits (177), Expect = 6e-13
Identities = 62/250 (24%), Positives = 106/250 (42%), Gaps = 26/250 (10%)
Query: 146 GLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD---LKD 202
G G+++++D+ +G LL + H + ++ +PD V+ DK+++ WD +KD
Sbjct: 472 GTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPD-QRGFVTGGADKSVKFWDFELVKD 530
Query: 203 DGNMMKVLRGHQNW-------VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH 255
+ + K L Q V ++SP+ +L V ++ +D L GH
Sbjct: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315
V+ D S DGAL+AT S D V IW GD +FA + +++
Sbjct: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDC----------HKSLFAHDDSVMYLQ 640
Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDG 373
V SH + D ++ W D+ +Q + C A S G + + +HD
Sbjct: 641 FVPKSH---LFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDK 697
Query: 374 SVYFWATPRQ 383
S+ W R+
Sbjct: 698 SLRLWERTRE 707
Score = 60.5 bits (145), Expect = 3e-09
Identities = 36/146 (24%), Positives = 70/146 (47%), Gaps = 2/146 (1%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D L LA G +G I+I+ + +G+ + H + L + G L S S+D + VW
Sbjct: 76 DGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGR-LASGSKDTDIIVW 134
Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHD 258
D+ ++ + + L+GH++ + F + ++L + G V W++D + + GH +
Sbjct: 135 DVINESGLYR-LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE 193
Query: 259 VVACDFSPDGALLATASYDTRVYIWD 284
V + L T + D+ + +WD
Sbjct: 194 VWGLVLLSEEKRLITGASDSELRVWD 219
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 2/115 (1%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D L+ATG + +KIW + G +L H + V L F P L +A +D ++ W
Sbjct: 602 DGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF-TAGKDHKIKQW 660
Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE 253
D D ++ L GH ++ A SP + S K++ LW + +I + E
Sbjct: 661 DA-DKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714
Score = 47.8 bits (112), Expect = 2e-05
Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 4/132 (3%)
Query: 154 IWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD-LKDDGNMMKVLRG 212
IWD+ G+ +L L + V L +PDG L L D ++R++ L +GN+ G
Sbjct: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDG-LHLAVGYEDGSIRIFSLLSGEGNV--TFNG 105
Query: 213 HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLA 272
H+ + + + L S + +W++ + + +L+GH + F + LL
Sbjct: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
Query: 273 TASYDTRVYIWD 284
T+ DT V WD
Sbjct: 166 TSGKDTMVKWWD 177
Score = 42.0 bits (97), Expect = 0.001
Identities = 25/101 (24%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
LA+G + I +WDV L L H + + F + +L LV++ +D ++ WDL D
Sbjct: 122 LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNL-LVTSGKDTMVKWWDL-D 179
Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM 243
+ K + GH+ V+ + L + + + +W++
Sbjct: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
Score = 35.4 bits (80), Expect = 0.098
Identities = 33/148 (22%), Positives = 57/148 (38%), Gaps = 14/148 (9%)
Query: 197 VWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
+WDL+ G + +L+G + V SPD L ++ ++++ GH
Sbjct: 49 IWDLRK-GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107
Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRS 316
+ + G LA+ S DT + +WD N L G D ++
Sbjct: 108 AAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL------------KGHKDAITQA 155
Query: 317 VSFSHDGLHVASLADDKMVRFWRIDEDY 344
+ L V S D MV++W +D +
Sbjct: 156 LFLREKNLLVTS-GKDTMVKWWDLDTQH 182
Score = 33.5 bits (75), Expect = 0.37
Identities = 20/65 (30%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F +++ LL T + +K WD+ T +V H V L + ++ AS D L
Sbjct: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS-DSEL 215
Query: 196 RVWDL 200
RVWD+
Sbjct: 216 RVWDI 220
Score = 31.6 bits (70), Expect = 1.4
Identities = 22/67 (32%), Positives = 34/67 (50%), Gaps = 1/67 (1%)
Query: 231 SVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDI 290
+V A + VF+W++ K I L+G +V SPDG LA D + I+ +G+
Sbjct: 40 AVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEG 99
Query: 291 LMEF-GH 296
+ F GH
Sbjct: 100 NVTFNGH 106
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 81.3 bits (199), Expect = 2e-15
Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 35/270 (12%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D+ ++ TG ++ +++WDV TG++L L+ H E V L F+ + ++V+ S+D+++ VW
Sbjct: 289 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVW 345
Query: 199 DLKD--DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
D+ D + +VL GH+ V F D + S + + +W+ +R L GH
Sbjct: 346 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 403
Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVR 315
+ + L+ + S D + +WD G L GH + VR
Sbjct: 404 RGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGH--------------EELVR 447
Query: 316 SVSFSHDGLHVASLADDKMVRFW----RIDEDYPVQVAPL-----SNGLCCAFSTDGSVL 366
+ F D + S A D ++ W +D P L +G D +
Sbjct: 448 CIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQI 505
Query: 367 AAGTHDGSVYFWATPRQVPSLQHLCRMSIR 396
+ +HD ++ W PS Q+ R R
Sbjct: 506 ISSSHDDTILIWDFLNVPPSAQNETRSPSR 535
Score = 67.8 bits (164), Expect = 2e-11
Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 26/243 (10%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D + +GL + IKIWD + + L L HT V L + ++V+ S D T+RVW
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVW 305
Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI---RKLEGH 255
D+ + G ++ L H V FS + CS S AV W+M T I R L GH
Sbjct: 306 DV-NTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASATDITLRRVLVGH 362
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315
V DF D + +AS D + +W + + + R +
Sbjct: 363 RAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-------------NGHKRGIA 407
Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
+ + D L V S + D +R W I+ ++V L D + +G +DG +
Sbjct: 408 CLQY-RDRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 465
Query: 376 YFW 378
W
Sbjct: 466 KVW 468
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 26/164 (15%)
Query: 45 DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHII 104
D Y + G RT+K+ S C L+G K R R G N R I
Sbjct: 372 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWDI 430
Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG---- 160
+CG + L E+ RC+ D + +G +G+IK+WD+
Sbjct: 431 ECGACLRVL----EGHEELVRCIRF---------DNKRIVSGAYDGKIKVWDLQAALDPR 477
Query: 161 -----KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199
L LV+H+ V L F ++S+S D T+ +WD
Sbjct: 478 APASTLCLRTLVEHSGRVFRLQF---DEFQIISSSHDDTILIWD 518
>gi|148536855 coatomer protein complex, subunit alpha isoform 1
[Homo sapiens]
Length = 1233
Score = 81.3 bits (199), Expect = 2e-15
Identities = 66/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%)
Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
+ T L+NG I++WD L+ +H VR + F L VS D ++VW+ K
Sbjct: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLF-VSGGDDYKIKVWNYKL 82
Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
+ +L GH +++ + F + + S + + +WN T + L GH+H V+
Sbjct: 83 RRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141
Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP--------TPIFAGGANDRWV 314
F P L+ +AS D V +WD + +L P T + G D V
Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISG----LRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197
Query: 315 RSVSFSHD-GLH----------VASLADDKMVRFWRIDEDYPVQV----APLSNGLCCAF 359
+ V HD G++ + S ADD+ V+ WR++E +V +N C F
Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257
Query: 360 STDGSVLAAGTHDGSVYFW 378
++ + + D S+ W
Sbjct: 258 HPRQELILSNSEDKSIRVW 276
Score = 56.6 bits (135), Expect = 4e-08
Identities = 42/162 (25%), Positives = 65/162 (40%), Gaps = 30/162 (18%)
Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD--------- 202
I++W+ + + L H V F P L+ VSAS D+T+RVWD+
Sbjct: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV-VSASLDQTVRVWDISGLRKKNLSPG 175
Query: 203 ------------------DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244
D + VL GH V AF P ++ S + V +W M+
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Query: 245 --KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
K + GH+++V F P L+ + S D + +WD
Sbjct: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
Score = 40.0 bits (92), Expect = 0.004
Identities = 35/165 (21%), Positives = 62/165 (37%), Gaps = 17/165 (10%)
Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
V +F P + + + + LW+ T+I K + H V DF L +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
Query: 277 DTRVYIWDPHNGDILME-FGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 335
D ++ +W+ L GHL ++R+ F H+ + S +DD+ +
Sbjct: 72 DYKIKVWNYKLRRCLFTLLGHL--------------DYIRTTFFHHEYPWILSASDDQTI 117
Query: 336 RFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
R W V V N +C F ++ + + D +V W
Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 40.0 bits (92), Expect = 0.004
Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 2/92 (2%)
Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM-MKVLRGHQNWVYSCAFSP 224
L H V F P LI VS + D+ +++W + + + RGH N V F P
Sbjct: 201 LEGHDRGVNWAAFHPTMPLI-VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259
Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
++ S K++ +W+M K T ++ H
Sbjct: 260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRDH 291
Score = 35.4 bits (80), Expect = 0.098
Identities = 53/198 (26%), Positives = 79/198 (39%), Gaps = 26/198 (13%)
Query: 38 WTVAFAPDGSYFAWSQGHRTVKLV-----PWSQCLQNFLLHGTKNVTNSSSL-RLPRQNS 91
W ++ + D + W+ RT V + C Q H T+++ S+SL + R
Sbjct: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQ---FHPTEDLVVSASLDQTVRVWD 163
Query: 92 DGGQKNK---PREHIIDCGDIVWSLAFGSS------VPEKQSRCVNIEWHRFRFGQDQLL 142
G + K P D I FG++ V E R VN W F L
Sbjct: 164 ISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVN--WAAFH--PTMPL 219
Query: 143 LATGLNNGRIKIWDVYTGKL--LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
+ +G ++ ++KIW + K + H V F P LIL S S DK++RVWD+
Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL-SNSEDKSIRVWDM 278
Query: 201 KDDGNMMKVLRGHQN-WV 217
+ R H WV
Sbjct: 279 SKRTGVQTFRRDHDRFWV 296
>gi|148536853 coatomer protein complex, subunit alpha isoform 2
[Homo sapiens]
Length = 1224
Score = 81.3 bits (199), Expect = 2e-15
Identities = 66/259 (25%), Positives = 111/259 (42%), Gaps = 29/259 (11%)
Query: 143 LATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD 202
+ T L+NG I++WD L+ +H VR + F L VS D ++VW+ K
Sbjct: 24 ILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLF-VSGGDDYKIKVWNYKL 82
Query: 203 DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVAC 262
+ +L GH +++ + F + + S + + +WN T + L GH+H V+
Sbjct: 83 RRCLFTLL-GHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCA 141
Query: 263 DFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPP--------TPIFAGGANDRWV 314
F P L+ +AS D V +WD + +L P T + G D V
Sbjct: 142 QFHPTEDLVVSASLDQTVRVWDISG----LRKKNLSPGAVESDVRGITGVDLFGTTDAVV 197
Query: 315 RSVSFSHD-GLH----------VASLADDKMVRFWRIDEDYPVQV----APLSNGLCCAF 359
+ V HD G++ + S ADD+ V+ WR++E +V +N C F
Sbjct: 198 KHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVF 257
Query: 360 STDGSVLAAGTHDGSVYFW 378
++ + + D S+ W
Sbjct: 258 HPRQELILSNSEDKSIRVW 276
Score = 56.6 bits (135), Expect = 4e-08
Identities = 42/162 (25%), Positives = 65/162 (40%), Gaps = 30/162 (18%)
Query: 152 IKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKD--------- 202
I++W+ + + L H V F P L+ VSAS D+T+RVWD+
Sbjct: 117 IRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLV-VSASLDQTVRVWDISGLRKKNLSPG 175
Query: 203 ------------------DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMD 244
D + VL GH V AF P ++ S + V +W M+
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235
Query: 245 --KYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYIWD 284
K + GH+++V F P L+ + S D + +WD
Sbjct: 236 ESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWD 277
Score = 40.0 bits (92), Expect = 0.004
Identities = 35/165 (21%), Positives = 62/165 (37%), Gaps = 17/165 (10%)
Query: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASY 276
V +F P + + + + LW+ T+I K + H V DF L +
Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGD 71
Query: 277 DTRVYIWDPHNGDILME-FGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMV 335
D ++ +W+ L GHL ++R+ F H+ + S +DD+ +
Sbjct: 72 DYKIKVWNYKLRRCLFTLLGHL--------------DYIRTTFFHHEYPWILSASDDQTI 117
Query: 336 RFWRIDEDYPVQVAPLSNG--LCCAFSTDGSVLAAGTHDGSVYFW 378
R W V V N +C F ++ + + D +V W
Sbjct: 118 RVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVW 162
Score = 40.0 bits (92), Expect = 0.004
Identities = 25/92 (27%), Positives = 41/92 (44%), Gaps = 2/92 (2%)
Query: 166 LVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM-MKVLRGHQNWVYSCAFSP 224
L H V F P LI VS + D+ +++W + + + RGH N V F P
Sbjct: 201 LEGHDRGVNWAAFHPTMPLI-VSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHP 259
Query: 225 DSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
++ S K++ +W+M K T ++ H
Sbjct: 260 RQELILSNSEDKSIRVWDMSKRTGVQTFRRDH 291
Score = 35.4 bits (80), Expect = 0.098
Identities = 53/198 (26%), Positives = 79/198 (39%), Gaps = 26/198 (13%)
Query: 38 WTVAFAPDGSYFAWSQGHRTVKLV-----PWSQCLQNFLLHGTKNVTNSSSL-RLPRQNS 91
W ++ + D + W+ RT V + C Q H T+++ S+SL + R
Sbjct: 107 WILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQ---FHPTEDLVVSASLDQTVRVWD 163
Query: 92 DGGQKNK---PREHIIDCGDIVWSLAFGSS------VPEKQSRCVNIEWHRFRFGQDQLL 142
G + K P D I FG++ V E R VN W F L
Sbjct: 164 ISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVN--WAAFH--PTMPL 219
Query: 143 LATGLNNGRIKIWDVYTGKL--LLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDL 200
+ +G ++ ++KIW + K + H V F P LIL S S DK++RVWD+
Sbjct: 220 IVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELIL-SNSEDKSIRVWDM 278
Query: 201 KDDGNMMKVLRGHQN-WV 217
+ R H WV
Sbjct: 279 SKRTGVQTFRRDHDRFWV 296
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 81.3 bits (199), Expect = 2e-15
Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 35/270 (12%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D+ ++ TG ++ +++WDV TG++L L+ H E V L F+ + ++V+ S+D+++ VW
Sbjct: 255 DERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS---NGLMVTCSKDRSIAVW 311
Query: 199 DLKD--DGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHH 256
D+ D + +VL GH+ V F D + S + + +W+ +R L GH
Sbjct: 312 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369
Query: 257 HDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVR 315
+ + L+ + S D + +WD G L GH + VR
Sbjct: 370 RGIACLQYR--DRLVVSGSSDNTIRLWDIECGACLRVLEGH--------------EELVR 413
Query: 316 SVSFSHDGLHVASLADDKMVRFW----RIDEDYPVQVAPL-----SNGLCCAFSTDGSVL 366
+ F D + S A D ++ W +D P L +G D +
Sbjct: 414 CIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQI 471
Query: 367 AAGTHDGSVYFWATPRQVPSLQHLCRMSIR 396
+ +HD ++ W PS Q+ R R
Sbjct: 472 ISSSHDDTILIWDFLNVPPSAQNETRSPSR 501
Score = 67.8 bits (164), Expect = 2e-11
Identities = 65/243 (26%), Positives = 100/243 (41%), Gaps = 26/243 (10%)
Query: 139 DQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198
D + +GL + IKIWD + + L L HT V L + ++V+ S D T+RVW
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY---DERVIVTGSSDSTVRVW 271
Query: 199 DLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI---RKLEGH 255
D+ + G ++ L H V FS + CS S AV W+M T I R L GH
Sbjct: 272 DV-NTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAV--WDMASATDITLRRVLVGH 328
Query: 256 HHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVR 315
V DF D + +AS D + +W + + + R +
Sbjct: 329 RAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-------------NGHKRGIA 373
Query: 316 SVSFSHDGLHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSV 375
+ + D L V S + D +R W I+ ++V L D + +G +DG +
Sbjct: 374 CLQY-RDRL-VVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKI 431
Query: 376 YFW 378
W
Sbjct: 432 KVW 434
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/164 (26%), Positives = 64/164 (39%), Gaps = 26/164 (15%)
Query: 45 DGSYFAWSQGHRTVKLVPWSQCLQNFLLHGTKNVTNSSSLRLPRQNSDGGQKNKPREHII 104
D Y + G RT+K+ S C L+G K R R G N R I
Sbjct: 338 DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-DRLVVSGSSDNTIRLWDI 396
Query: 105 DCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLNNGRIKIWDVYTG---- 160
+CG + L E+ RC+ D + +G +G+IK+WD+
Sbjct: 397 ECGACLRVL----EGHEELVRCIRF---------DNKRIVSGAYDGKIKVWDLQAALDPR 443
Query: 161 -----KLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWD 199
L LV+H+ V L F ++S+S D T+ +WD
Sbjct: 444 APASTLCLRTLVEHSGRVFRLQF---DEFQIISSSHDDTILIWD 484
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 81.3 bits (199), Expect = 2e-15
Identities = 45/180 (25%), Positives = 81/180 (45%), Gaps = 20/180 (11%)
Query: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 228
HT + F PD + S S D+ +++WD+ ++ + + H N + +C F+
Sbjct: 229 HTRSITSCCFDPDSQRV-ASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHF 287
Query: 229 LCSVGASKAVFLWNM------DKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVYI 282
LC+ K + +WN+ + + ++GH V +C F+ D + L + +D V I
Sbjct: 288 LCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAI 347
Query: 283 WDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDE 342
WD G + G ND WV V+ S++ + S + D+ +R W I+E
Sbjct: 348 WDVAEG------------YRKLSLKGHND-WVMDVAISNNKKWILSASKDRTMRLWNIEE 394
Score = 65.9 bits (159), Expect = 7e-11
Identities = 41/139 (29%), Positives = 73/139 (52%), Gaps = 7/139 (5%)
Query: 152 IKIWDVYTGKLLLNLVD-HTEVVRDLTFAPDGSLILVSASRDKTLRVWDL-----KDDGN 205
IKIWDV + LL + H+ + + F G + S S DK L++W++ ++ G
Sbjct: 254 IKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTS-SWDKNLKIWNVHTGEFRNCGA 312
Query: 206 MMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFS 265
+ +++GH+ V SC F+ DSS L S G + V +W++ + L+GH+ V+ S
Sbjct: 313 CVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAIS 372
Query: 266 PDGALLATASYDTRVYIWD 284
+ + +AS D + +W+
Sbjct: 373 NNKKWILSASKDRTMRLWN 391
Score = 55.8 bits (133), Expect = 7e-08
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 13/119 (10%)
Query: 252 LEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGAND 311
L GH H V C F D L + SYD V +WDP +G ++ +F H P P+
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEH--RPKAPVV------ 149
Query: 312 RWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGLCCAFSTDGSVLAAG 369
S + D V + + DK VR W ++ + +V + + C FS DG + +G
Sbjct: 150 ----ECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSG 204
Score = 54.3 bits (129), Expect = 2e-07
Identities = 49/205 (23%), Positives = 78/205 (38%), Gaps = 34/205 (16%)
Query: 208 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGH-HHDVVACDFSP 266
K+L GH++ V +C F D + L S V LW+ +++R E VV C +
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 267 DGALLATASYDTRVYIWDPHNGDILMEFGH-------LFPPPTPIFAGG----------- 308
D + + ASYD V WD G +L + + F P G
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215
Query: 309 ---------ANDRWVRSVS---FSHDGLHVASLADDKMVRFWRIDEDYPVQVAPL--SNG 354
D RS++ F D VAS++ D+ ++ W + + SN
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275
Query: 355 LC-CAFSTDGSVLAAGTHDGSVYFW 378
+ C F+ G L + D ++ W
Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIW 300
Score = 44.7 bits (104), Expect = 2e-04
Identities = 24/76 (31%), Positives = 44/76 (57%), Gaps = 1/76 (1%)
Query: 136 FGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTL 195
F +D L +G + + IWDV G L+L H + V D+ + + IL SAS+D+T+
Sbjct: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWIL-SASKDRTM 387
Query: 196 RVWDLKDDGNMMKVLR 211
R+W++++ + V++
Sbjct: 388 RLWNIEEIDEIPLVIK 403
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,993,736
Number of Sequences: 37866
Number of extensions: 810764
Number of successful extensions: 4499
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 240
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 1616
Number of HSP's gapped (non-prelim): 1540
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.