BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo sapiens] (1722 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 3481 0.0 gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 1571 0.0 gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 1330 0.0 gi|206725526 signal-induced proliferation-associated protein 1 [... 617 e-176 gi|206725523 signal-induced proliferation-associated protein 1 [... 617 e-176 gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 230 1e-59 gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 230 1e-59 gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 221 5e-57 gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 221 5e-57 gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 221 5e-57 gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 217 9e-56 gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 74 9e-13 gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 74 9e-13 gi|118600961 akt substrate AS250 [Homo sapiens] 70 1e-11 gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 67 2e-10 gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 67 2e-10 gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 67 2e-10 gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 49 4e-05 gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 49 6e-05 gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 46 4e-04 gi|119829187 alpha 1 type XVII collagen [Homo sapiens] 44 0.002 gi|148727255 microtubule associated serine/threonine kinase fami... 43 0.002 gi|31742501 sorting nexin family member 27 [Homo sapiens] 43 0.003 gi|169173184 PREDICTED: hypothetical protein [Homo sapiens] 42 0.007 gi|57864582 hornerin [Homo sapiens] 41 0.009 gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 41 0.011 gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 40 0.015 gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 40 0.026 gi|8923040 CDKN2A interacting protein [Homo sapiens] 39 0.044 gi|45827729 scribble isoform b [Homo sapiens] 39 0.044 >gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo sapiens] Length = 1722 Score = 3481 bits (9025), Expect = 0.0 Identities = 1722/1722 (100%), Positives = 1722/1722 (100%) Query: 1 MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG 60 MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG Sbjct: 1 MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG 60 Query: 61 GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD 120 GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD Sbjct: 61 GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD 120 Query: 121 QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV 180 QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV Sbjct: 121 QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV 180 Query: 181 NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI 240 NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI Sbjct: 181 NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI 240 Query: 241 SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS 300 SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS Sbjct: 241 SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS 300 Query: 301 EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG 360 EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG Sbjct: 301 EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG 360 Query: 361 ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG 420 ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG Sbjct: 361 ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG 420 Query: 421 DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI 480 DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI Sbjct: 421 DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI 480 Query: 481 DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL 540 DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL Sbjct: 481 DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL 540 Query: 541 TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE 600 TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE Sbjct: 541 TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE 600 Query: 601 QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK 660 QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK Sbjct: 601 QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK 660 Query: 661 TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT 720 TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT Sbjct: 661 TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT 720 Query: 721 PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL 780 PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL Sbjct: 721 PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL 780 Query: 781 LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK 840 LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK Sbjct: 781 LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK 840 Query: 841 VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV 900 VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV Sbjct: 841 VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV 900 Query: 901 IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ 960 IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ Sbjct: 901 IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ 960 Query: 961 LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV 1020 LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV Sbjct: 961 LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV 1020 Query: 1021 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA 1080 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA Sbjct: 1021 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA 1080 Query: 1081 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP 1140 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP Sbjct: 1081 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP 1140 Query: 1141 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ 1200 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ Sbjct: 1141 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ 1200 Query: 1201 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG 1260 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG Sbjct: 1201 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG 1260 Query: 1261 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA 1320 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA Sbjct: 1261 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA 1320 Query: 1321 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP 1380 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP Sbjct: 1321 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP 1380 Query: 1381 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA Sbjct: 1381 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440 Query: 1441 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS 1500 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS Sbjct: 1441 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS 1500 Query: 1501 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA 1560 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA Sbjct: 1501 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA 1560 Query: 1561 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH 1620 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH Sbjct: 1561 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH 1620 Query: 1621 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA 1680 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA Sbjct: 1621 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA 1680 Query: 1681 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS 1722 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS Sbjct: 1681 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS 1722 >gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo sapiens] Length = 1804 Score = 1571 bits (4067), Expect = 0.0 Identities = 929/1874 (49%), Positives = 1185/1874 (63%), Gaps = 227/1874 (12%) Query: 1 MSDPRQSQEEKH-KLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNET 59 M+ ++SQ E+ RAS D + +DD++ R+F++ NG++G + + + Sbjct: 1 MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSV-MAPVGPPRS 59 Query: 60 GGGGPANGTPAVPKMGVRARVSEWPPKKDCSKELT--CKALWESRSQTSYESITSVLQNG 117 G TP VPKMGVRAR+++WPP+K+ KE + + + S S S +S + G Sbjct: 60 EGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQG 119 Query: 118 QSDQSEGQQDEQLDL------------DFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVT 165 S L + +++++ + + + SP++ L IRQRSNSD+T Sbjct: 120 SSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDIT 179 Query: 166 ISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAM 225 IS++D + + + TG +LHREYGSTSSID+QG SGE+FF +L+GY+ + D + Sbjct: 180 ISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSD-RGP 238 Query: 226 VPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLDYVDSA------LLMGRDRDKPFK 279 P +F I+ G LD +D L + ++R+KP K Sbjct: 239 TPTKLSDFL---------------ITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLK 283 Query: 280 RRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILF 339 RR KSE+ ++S+FRKLR K E +S+LE++R E +RPW C +CFAHYDVQSILF Sbjct: 284 RRSKSETGDSSIFRKLRNAKGEE--LGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILF 341 Query: 340 NINEAMATRANVGKRKNITTGASAASQTQM---PTGQTGNCESPLGSKEDLNSKENLDAD 396 ++NEA+ R NV KR+N TTGASAA+ + P + + SP+GS EDLNSK +L D Sbjct: 342 DLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMD 401 Query: 397 EGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVS 456 +GD KSN+LV+SCPYFRNE GGEG+R+I+LS++NS SFS ES SFES+LSSHCTNAGV+ Sbjct: 402 QGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVA 461 Query: 457 VLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRRE 516 VLEVP+EN +H ++VKRYI+EH+DLGAYYYRKFFY KEH NYFG DENLGPVAVSIRRE Sbjct: 462 VLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRRE 521 Query: 517 KVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPE 576 K ++ KE GS +NYR+ FRTSEL TLRG++LEDAIPSTA+H TARGLPLKEVLE+V+PE Sbjct: 522 KPDEMKEN-GSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPE 580 Query: 577 LSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEE 636 L++QCLR A N+PKV+EQL+KLDEQGL++Q K+GI+YCKAGQSTEEEMYNNE+AGPAFEE Sbjct: 581 LNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEE 640 Query: 637 FLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQL 696 FL LLG+RVRLKGF KYRAQLD KTDSTGTHSLYTTYKDYE+MFHVST+LPY PNN+QQL Sbjct: 641 FLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQL 700 Query: 697 LRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKD 756 LRKRHIGNDIVTIVFQEPGA PF+PK+IRSHFQHVFVIV+VHNPC+++VCYSV V+RS+D Sbjct: 701 LRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRD 760 Query: 757 VPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENF 816 VP FGPPIPKGVTFPKS VFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAE Sbjct: 761 VPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKN 820 Query: 817 VTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGI 876 VT +D S KF FI+L +KKKEK KP A L S+GAI+W V A D+ ++ +++CLLGI Sbjct: 821 VTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGI 880 Query: 877 SNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIV 936 SNEFI+LIE+++K+VVFNCSCRDVIGWTS S+K+FYERGECV + S N E+I+EIV Sbjct: 881 SNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFIN-IEEIKEIV 939 Query: 937 QRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICK 996 +RL V++GCE+VEMTLRRNGLGQLGFHVN+EGIVADVEP+G+AW+AGLRQGSRLVEICK Sbjct: 940 KRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICK 999 Query: 997 VAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEY 1056 VAVATL+HEQMIDLLRTSVTVKVVII PHDD +PRR CSE R+P++EYK+ +EG E+ Sbjct: 1000 VAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKM-NEGVSYEF 1058 Query: 1057 KTPFRRNTTWHR----------VPTPALQPL-SRASPIPGTPDRLPCQQLLQQAQAAIPR 1105 K PFR N W R VP+ P+ SR + G P + A IPR Sbjct: 1059 KFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPP-----PERAANIPR 1113 Query: 1106 STSFD-----RKLPDGT----------------RSSPSNQSSSSDPGPGGSGPWRPQVGY 1144 S S D R+L G+ R+SPSN SSSSD G G G +R + Sbjct: 1114 SISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVG-GTYRQKSMP 1172 Query: 1145 DGC----QSPLLLEHQ-------GSGPLECDGARERED------------------TMEA 1175 +G +SP ++ Q GSG R + +E Sbjct: 1173 EGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQ 1232 Query: 1176 SRHPETKWHGPP-SKVLGSYKE----RALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLS 1230 + E H P SKVL +++E R +++D SPNK H D SSHSSSNTLS Sbjct: 1233 HEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGH-SDSHYSSHSSSNTLS 1291 Query: 1231 SNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVH-----LAG 1285 SN SS D+ + GD + EL Y++G S DSGIDT T GP H L Sbjct: 1292 SNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDT------TSYGPSHGSTASLGA 1345 Query: 1286 SRSLIHSR------AEQWADAADVSGPDD--------------EPAKLYSVHGYASTISA 1325 + S S A W +++V D E + +H + S Sbjct: 1346 ATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGST 1405 Query: 1326 GSAAEGSMGDLSEISSHSS--GSHHSGSPSAHCSKSSGSLD-----SSKVYIVSHSSGQQ 1378 E S +++ +SH+S S HS SP S S + + S SS Sbjct: 1406 PLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSS 1465 Query: 1379 VPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVG 1438 Y RQGA +KY+IGWKK EG+ + + M T +HQ+ G Sbjct: 1466 SSSGPRSFYPRQGATSKYLIGWKKPEGT--------------INSVGFMDTRKRHQS-DG 1510 Query: 1439 DAVAETQHVLS----------------KEDFLKLMLPDSPLVEEGRRKFSFYGNLSP--- 1479 + +A T+ S +ED KL+ +SP E ++ F F+ SP Sbjct: 1511 NEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESP-TPESQKSFKFHALSSPQSP 1569 Query: 1480 -------RRSLYRTLSDESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPR 1532 RR+L+RTLSDESI +++R F +SR+S+LDQALPND+LFS+T P P Sbjct: 1570 FPSTPTSRRALHRTLSDESIYNSQR-EHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPL 1628 Query: 1533 AHPAPSMG--SLRNEFWFSDGSLSD-----KSKCADPGLMPLPDTATGLDWTHLVDAARA 1585 P+ ++G SL EF SD SL+D + DPGLMPLPDTA LDW++LVDAA+A Sbjct: 1629 RRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKA 1688 Query: 1586 FEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQHGQDLEGAQELPLCVDPGSGKEFMDT 1645 +E + ASF +D H + L A D + + Sbjct: 1689 YE-------------------VQRASFFAASDENH-RPLSAASNSDQLEDQALAQMKPYS 1728 Query: 1646 TGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATA 1705 + + S L KV+QLE +L+ L+ DL+KEK+DKA LQAEVQHLR+DN+RLQEESQ A+ Sbjct: 1729 SSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASD 1788 Query: 1706 QLRKFTEWFFTTID 1719 +L+KFTEW F TID Sbjct: 1789 KLKKFTEWVFNTID 1802 >gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo sapiens] Length = 1781 Score = 1330 bits (3443), Expect = 0.0 Identities = 825/1797 (45%), Positives = 1059/1797 (58%), Gaps = 169/1797 (9%) Query: 32 DYFARKFKAINGNMGPTTSLNASNSNETGGGG--PANGTPAVPKMGVRARVSEWPPKKDC 89 DY F A NG+M + + + T P+ TPA+PKMGVRARV++WPPK++ Sbjct: 33 DYAPLGFWAQNGSMSQPLGESPATATATATATTRPSPTTPAMPKMGVRARVADWPPKREA 92 Query: 90 SKELTCKALWESRSQTSYESITSVL---QNGQSDQSEGQQDEQLDLDFVEAKYT----IG 142 +E + + + T + + QNGQ S + + + Sbjct: 93 LREHSNPSPSQDTDGTKATKMAHSMRSIQNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQ 152 Query: 143 DIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQG 202 D + SP R P+R RS+S++T+S+ DAED + L REYGSTSSID QG Sbjct: 153 DGWPRSPGRAFLPLRHRSSSEITLSECDAEDAGEPRGARHTGALPLFREYGSTSSIDVQG 212 Query: 203 LSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLD 262 + ++FF +L +R E D + E R DP P L ++G+ +G Sbjct: 213 MPEQSFFDILNEFRSEQPDARGCQ--ALTELLRADPG--PHLMGGGGGAKGD--SHNGQP 266 Query: 263 YVDSALLMGRDRDKPFKRRLKS------ESVETSLFRKLRTVKSEHETFKFTSELEESRL 316 DS L + ++K R+ + ++V++S+FRKLR+ K E E + E +E R Sbjct: 267 AKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSSIFRKLRSSKPEGEAGRSPGEADEGRS 326 Query: 317 E-RGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPTGQTG 375 RPW CQ+ FAH+DVQS+LF++NEA A R +V +R+N TTGASAAS T Sbjct: 327 PPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTA 386 Query: 376 NCESPLG-------SKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSR 428 + LG S EDLN KENL+ D GD SNDL+LSCP+FRNE GGE +R ++ SR Sbjct: 387 SRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSR 446 Query: 429 ANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYR 488 A+ S SSGE E +LS++ TNA +SVLEVP+E Q + + ++Y IEH+DLGA YY+ Sbjct: 447 ASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRT-QSRPRQYSIEHVDLGARYYQ 505 Query: 489 KFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAIL 548 +F GKEH NYFG+DE LGPVAVSI+REK+ED KE G Q+ YR+ FRT EL TLRG+IL Sbjct: 506 DYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKE-HGPQYQYRIIFRTRELITLRGSIL 564 Query: 549 EDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHK 608 EDA P+ +HGT RGLPLK+ LEYVIPEL+I CLR A N+PKV+EQLLKLDEQGL +HK Sbjct: 565 EDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHK 624 Query: 609 IGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHS 668 +GILYCKAGQS+EEEMYNNE AGPAFEEFL L+G++V LKGF+KY AQLD KTDSTGTHS Sbjct: 625 VGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHS 684 Query: 669 LYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHF 728 LYT Y+DYE+MFHVSTLLPY PNNRQQLLRKRHIGNDIVTI+FQEPGALPFTPK+IRSHF Sbjct: 685 LYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHF 744 Query: 729 QHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAE 788 QHVF+IV+VHNPCT+NVCYS+ V+RSKD PPFGPPIP G TF KS VFRDFLLAKVINAE Sbjct: 745 QHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAE 804 Query: 789 NAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAH 848 NAAHKS+KF MATRTRQEYLKDLAEN V+ +D++ KF+ I+L +KKKEK K R A Sbjct: 805 NAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAE 864 Query: 849 LFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLV 908 S GAI W V+A+D+ Q +I+C+LGISNEF++L++ +K VVFNC C DVIGWT Sbjct: 865 QHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSS 924 Query: 909 SIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFE 968 ++K+FY RG+ + L + + EDIREIVQRL ++T G ETV+MTLRRNGLGQLGFHV ++ Sbjct: 925 TLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYD 984 Query: 969 GIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDG 1028 G VA+VE +GFAW+AGLRQGSRLVEICKVAV TLTH+QMIDLLRTSVTVKVVII P +DG Sbjct: 985 GTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDG 1044 Query: 1029 SPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWH---------------RVPTPA 1073 +PRRG E + E K + E + P+R N W PT Sbjct: 1045 TPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTP 1104 Query: 1074 LQPLSRASPIPGTP--DRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPG 1131 S + P+ TP Q L + + P T + R P Q S S Sbjct: 1105 GHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFP-ETPYTVSPAGADRVPPYRQPSGSFST 1163 Query: 1132 PGGSGPWRPQVG---YDGCQSPLL-----LEHQG--SGPLECDGAREREDTMEASRHPET 1181 PG + R + Y PLL H G SG G +E TME + PE Sbjct: 1164 PGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQK-PEP 1222 Query: 1182 KWHGPP----SKVLGSY-KERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSN-TSS 1235 WH P S + GS + ++D + KDSPN+ S G+ SSHSSSNTLSSN +SS Sbjct: 1223 LWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSK-GEPQYSSHSSSNTLSSNASSS 1281 Query: 1236 NSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTA----------------PCMPATILG 1279 +SDD+ F D ++PE L+ KG S+DSGIDT P P G Sbjct: 1282 HSDDRWFDPLDPLEPEQDPLS--KGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPG 1339 Query: 1280 PVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTI--SAGSAAEGSMGDLS 1337 + L G R+ +VS PA GY + S S G G Sbjct: 1340 SMGLCGGGREAAGRSHHADRRREVS---PAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSR 1396 Query: 1338 EISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKP-YHRQGAVNKY 1396 + S A K++ S ++ + ++ S Q+ S+ K + +Q NK+ Sbjct: 1397 DPPRQPSDMGSRVGYPAQVYKTA-SAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKH 1455 Query: 1397 VIGWKKSEGSPP-------PEEPEVTECPGMYSE-------MDVMSTATQHQTVVGDAVA 1442 GWK++E PP P++ T ++ + D+ S +++ + D Sbjct: 1456 PTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIED--- 1512 Query: 1443 ETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFG 1502 D KL++ D+ E+ R SP++ L RTLSDES+CS RR SF Sbjct: 1513 ---------DLKKLIIMDNLGPEQERDT-----GQSPQKGLQRTLSDESLCSGRREPSFA 1558 Query: 1503 SSRSSVLDQALPNDILFSTTPPY-HSTLPPR---AHPAPSMG------------SLRNEF 1546 S L+ LP+D+LF++T + STLP R HP P +G ++ Sbjct: 1559 SPAG--LEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTI 1616 Query: 1547 WFSDGSLSD----KSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHT 1602 S+ SL+D + DPGLMPLPDTA GL+W+ LV+AA+A+E Sbjct: 1617 SASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYE--------------- 1661 Query: 1603 SYLDQRVASFCTLTDMQHGQDLEGA-----QELPLCVDPGSGKEFMDTTGERSPSPLTGK 1657 QR S +L D D+ A L L P + + T E P LTGK Sbjct: 1662 ---VQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRT-TPTMSEEPPLDLTGK 1717 Query: 1658 VNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWF 1714 V QLE++L+QL TDL+KEKQDK VLQ+EV LRQ+N RLQEESQ A+ QLRKF E F Sbjct: 1718 VYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAEIF 1774 >gi|206725526 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 617 bits (1590), Expect = e-176 Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%) Query: 327 RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385 R FAHYDVQS+LF+ A R+ +G ++G A+++ Q Sbjct: 114 RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152 Query: 386 DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445 S+DL+ P F E GGEG+ G Sbjct: 153 --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184 Query: 446 LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505 + NA VS+LE P+ + Y +EH DLGA YYRK+FYGKEHQN+FG+DE+ Sbjct: 185 VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237 Query: 506 LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565 LGPVAVS+RRE+ E + G+ +YRV RT++L TLRG I EDA+P G RGL Sbjct: 238 LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291 Query: 566 LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625 +++LE+V P+LS CLR S SPKV LL LDEQ LSFQ K+GILYC+AGQ +EEEMY Sbjct: 292 PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351 Query: 626 NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685 NN+ AGPAF +FL LLG VRLKGF YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+ Sbjct: 352 NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411 Query: 686 LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745 LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT + Sbjct: 412 LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471 Query: 746 CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804 Y V VSR++D P FGP +P G F +A FR FLLAK +N E AA + +F AMATRT Sbjct: 472 TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531 Query: 805 RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863 RQ+YL+DLA N VTT ++D++ +F +LG ++ + PR A L + G+++W V A Sbjct: 532 RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589 Query: 864 FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912 + A ++ CLLGIS E ++L+ VVFNC+CRDV+ WT + + Sbjct: 590 GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649 Query: 913 FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972 ++ RGE + L + + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V Sbjct: 650 YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709 Query: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032 VE F FA AGLR G+RL+ +C + +L E LLR++ V V ++ P + G PRR Sbjct: 710 HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769 Query: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058 SEL + + E L G+P E +T Sbjct: 770 SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829 Query: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117 F + +L P S S P P+ P L A+ ++P + S + L Sbjct: 830 EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881 Query: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162 SPS +P P + P+ ++ GSG LE Sbjct: 882 PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926 Score = 63.5 bits (153), Expect = 2e-09 Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%) Query: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557 S RSS+ D+A LPN D+L +TT PS+ S +E + S Sbjct: 839 SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886 Query: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617 D G P P+ + + + S+ G L + + +AS C Sbjct: 887 GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941 Query: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677 + EG Q +P DP K + E P L+ KV+ LE +LR+LQ DL+KEK Sbjct: 942 ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997 Query: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707 D+A L+ EV+ LR +N RLQ ES++A +L Sbjct: 998 DRAALEEEVRSLRHNNRRLQAESESAATRL 1027 >gi|206725523 signal-induced proliferation-associated protein 1 [Homo sapiens] Length = 1042 Score = 617 bits (1590), Expect = e-176 Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%) Query: 327 RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385 R FAHYDVQS+LF+ A R+ +G ++G A+++ Q Sbjct: 114 RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152 Query: 386 DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445 S+DL+ P F E GGEG+ G Sbjct: 153 --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184 Query: 446 LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505 + NA VS+LE P+ + Y +EH DLGA YYRK+FYGKEHQN+FG+DE+ Sbjct: 185 VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237 Query: 506 LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565 LGPVAVS+RRE+ E + G+ +YRV RT++L TLRG I EDA+P G RGL Sbjct: 238 LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291 Query: 566 LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625 +++LE+V P+LS CLR S SPKV LL LDEQ LSFQ K+GILYC+AGQ +EEEMY Sbjct: 292 PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351 Query: 626 NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685 NN+ AGPAF +FL LLG VRLKGF YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+ Sbjct: 352 NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411 Query: 686 LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745 LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT + Sbjct: 412 LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471 Query: 746 CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804 Y V VSR++D P FGP +P G F +A FR FLLAK +N E AA + +F AMATRT Sbjct: 472 TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531 Query: 805 RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863 RQ+YL+DLA N VTT ++D++ +F +LG ++ + PR A L + G+++W V A Sbjct: 532 RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589 Query: 864 FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912 + A ++ CLLGIS E ++L+ VVFNC+CRDV+ WT + + Sbjct: 590 GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649 Query: 913 FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972 ++ RGE + L + + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V Sbjct: 650 YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709 Query: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032 VE F FA AGLR G+RL+ +C + +L E LLR++ V V ++ P + G PRR Sbjct: 710 HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769 Query: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058 SEL + + E L G+P E +T Sbjct: 770 SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829 Query: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117 F + +L P S S P P+ P L A+ ++P + S + L Sbjct: 830 EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881 Query: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162 SPS +P P + P+ ++ GSG LE Sbjct: 882 PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926 Score = 63.5 bits (153), Expect = 2e-09 Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%) Query: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557 S RSS+ D+A LPN D+L +TT PS+ S +E + S Sbjct: 839 SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886 Query: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617 D G P P+ + + + S+ G L + + +AS C Sbjct: 887 GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941 Query: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677 + EG Q +P DP K + E P L+ KV+ LE +LR+LQ DL+KEK Sbjct: 942 ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997 Query: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707 D+A L+ EV+ LR +N RLQ ES++A +L Sbjct: 998 DRAALEEEVRSLRHNNRRLQAESESAATRL 1027 >gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2 [Homo sapiens] Length = 715 Score = 230 bits (586), Expect = 1e-59 Identities = 135/333 (40%), Positives = 184/333 (55%), Gaps = 32/333 (9%) Query: 487 YRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTS-----ELT 541 YR+ F GK+H N++ +LG + +S++ E E EG ++ RV R+ E Sbjct: 142 YRRHFLGKDHLNFYCTGSSLGNLILSVKCE------EAEGIEY-LRVILRSKLKTVHERI 194 Query: 542 TLRGAILEDAIPSTARH--GTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLD 599 L G ++P A+ A GL VL PK S+ ++ D Sbjct: 195 PLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLY-----------------PKASQMIVSYD 237 Query: 600 EQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDN 659 E ++ K G++Y KA Q+ EEE++ N PAF+EFLDLLG + L+ F +R LD Sbjct: 238 EHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDV 297 Query: 660 KTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPF 719 TG S+YTT++D E+MFHVST LP+ + QQL RKRHIGNDIV I+FQE PF Sbjct: 298 THGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENT-PF 356 Query: 720 TPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDF 779 P I S+F H +++V+V P TE Y V V+ +DVP FGPP+P F K FR+F Sbjct: 357 VPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREF 416 Query: 780 LLAKVINAENAAHKSEKFRAMATRTRQEYLKDL 812 LL K+ NAENA KS+KF + RTR L +L Sbjct: 417 LLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 449 >gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1 [Homo sapiens] Length = 730 Score = 230 bits (586), Expect = 1e-59 Identities = 135/333 (40%), Positives = 184/333 (55%), Gaps = 32/333 (9%) Query: 487 YRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTS-----ELT 541 YR+ F GK+H N++ +LG + +S++ E E EG ++ RV R+ E Sbjct: 157 YRRHFLGKDHLNFYCTGSSLGNLILSVKCE------EAEGIEY-LRVILRSKLKTVHERI 209 Query: 542 TLRGAILEDAIPSTARH--GTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLD 599 L G ++P A+ A GL VL PK S+ ++ D Sbjct: 210 PLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLY-----------------PKASQMIVSYD 252 Query: 600 EQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDN 659 E ++ K G++Y KA Q+ EEE++ N PAF+EFLDLLG + L+ F +R LD Sbjct: 253 EHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDV 312 Query: 660 KTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPF 719 TG S+YTT++D E+MFHVST LP+ + QQL RKRHIGNDIV I+FQE PF Sbjct: 313 THGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENT-PF 371 Query: 720 TPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDF 779 P I S+F H +++V+V P TE Y V V+ +DVP FGPP+P F K FR+F Sbjct: 372 VPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREF 431 Query: 780 LLAKVINAENAAHKSEKFRAMATRTRQEYLKDL 812 LL K+ NAENA KS+KF + RTR L +L Sbjct: 432 LLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 464 >gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapiens] Length = 663 Score = 221 bits (563), Expect = 5e-57 Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%) Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543 A YRK F GKEH NY+ +D LG + S++ + + G Q + R+ RT T Sbjct: 87 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 137 Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602 D IP + + + K V E V + L PK S ++ DE Sbjct: 138 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 188 Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662 +S K G++Y K GQ++EEE+++ PAF EFL+ LGQ+V+L+ F +R LD Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248 Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722 TGT S+Y +++ E+MFHVST LPY + QQL RKRHIGNDIV +VFQ+ PF P Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 307 Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782 I S+F H +V+V+ + Y V V+ DVP FGPP+P F K F++FLL Sbjct: 308 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 367 Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814 K+INAE A +K+EKF + RTR L+ L E Sbjct: 368 KLINAEYACYKAEKFAKLEERTRAALLETLYE 399 >gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapiens] Length = 727 Score = 221 bits (563), Expect = 5e-57 Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%) Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543 A YRK F GKEH NY+ +D LG + S++ + + G Q + R+ RT T Sbjct: 151 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 201 Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602 D IP + + + K V E V + L PK S ++ DE Sbjct: 202 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 252 Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662 +S K G++Y K GQ++EEE+++ PAF EFL+ LGQ+V+L+ F +R LD Sbjct: 253 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 312 Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722 TGT S+Y +++ E+MFHVST LPY + QQL RKRHIGNDIV +VFQ+ PF P Sbjct: 313 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 371 Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782 I S+F H +V+V+ + Y V V+ DVP FGPP+P F K F++FLL Sbjct: 372 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 431 Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814 K+INAE A +K+EKF + RTR L+ L E Sbjct: 432 KLINAEYACYKAEKFAKLEERTRAALLETLYE 463 >gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapiens] Length = 681 Score = 221 bits (563), Expect = 5e-57 Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%) Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543 A YRK F GKEH NY+ +D LG + S++ + + G Q + R+ RT T Sbjct: 87 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 137 Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602 D IP + + + K V E V + L PK S ++ DE Sbjct: 138 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 188 Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662 +S K G++Y K GQ++EEE+++ PAF EFL+ LGQ+V+L+ F +R LD Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248 Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722 TGT S+Y +++ E+MFHVST LPY + QQL RKRHIGNDIV +VFQ+ PF P Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 307 Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782 I S+F H +V+V+ + Y V V+ DVP FGPP+P F K F++FLL Sbjct: 308 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 367 Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814 K+INAE A +K+EKF + RTR L+ L E Sbjct: 368 KLINAEYACYKAEKFAKLEERTRAALLETLYE 399 >gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sapiens] Length = 1013 Score = 217 bits (552), Expect = 9e-56 Identities = 136/376 (36%), Positives = 202/376 (53%), Gaps = 31/376 (8%) Query: 477 IEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFR 536 +E+ + +Y K+F G+ HQNY G D P +S+ Q N RV Sbjct: 89 LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTL----------SDQNNQRVPQY 138 Query: 537 TSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLL 596 + L G + +P + + L +K +L + + + R+ + P++ + LL Sbjct: 139 RAILWRKTGT-QKICLP----YSPTKTLSVKSILSAMNLDKFEKGPREIFH-PEIQKDLL 192 Query: 597 KLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQ 656 L+EQ S K G+L+ K GQ T++EM++NE F++FL+LLG + LKG++ YR Sbjct: 193 VLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGG 252 Query: 657 LDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQ--EP 714 LD K D+TG HS+YT Y+ +E+MFHVST+LPY N+QQ+ RKRHIGNDIVTIVFQ E Sbjct: 253 LDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEE 312 Query: 715 GALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSA 774 + F P IRSHF H+F +V+ + +N Y + + + VP FGPP+P F Sbjct: 313 SSPAFKPSMIRSHFTHIFALVRYNQ---QNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQ 369 Query: 775 VFRDFLLAKVINAENAAHKSEKFRAMATRT--------RQEYLKDLAENFVTTATVDTSV 826 FRDFLL K+IN E A ++ F RT Q+ + DL +N + + + Sbjct: 370 EFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVL 429 Query: 827 KFSFITLGAKKKEKVK 842 S A+KKE+ + Sbjct: 430 PES--PKSARKKEEAR 443 >gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2 [Homo sapiens] Length = 2083 Score = 74.3 bits (181), Expect = 9e-13 Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 11/235 (4%) Query: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649 K+ +L LD + HKI + Y GQ + + N A+E+F+ LG V L Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850 Query: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708 + L K STG + Y E++FHVST +P ++ L +K RH+GND V Sbjct: 1851 HCGFMGGL-QKNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907 Query: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768 IV+ E + I + F V +++ +N +S+ + + +VP FGP + Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVIYP----MKNHMFSIQIMKKPEVPFFGPLFDGAI 1962 Query: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVD 823 K V + A INA A R YL+ + ++ + T + Sbjct: 1963 VNGK--VLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015 >gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1 [Homo sapiens] Length = 2036 Score = 74.3 bits (181), Expect = 9e-13 Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 11/235 (4%) Query: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649 K+ +L LD + HKI + Y GQ + + N A+E+F+ LG V L Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850 Query: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708 + L K STG + Y E++FHVST +P ++ L +K RH+GND V Sbjct: 1851 HCGFMGGL-QKNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907 Query: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768 IV+ E + I + F V +++ +N +S+ + + +VP FGP + Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVIYP----MKNHMFSIQIMKKPEVPFFGPLFDGAI 1962 Query: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVD 823 K V + A INA A R YL+ + ++ + T + Sbjct: 1963 VNGK--VLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015 >gi|118600961 akt substrate AS250 [Homo sapiens] Length = 1873 Score = 70.5 bits (171), Expect = 1e-11 Identities = 62/227 (27%), Positives = 101/227 (44%), Gaps = 11/227 (4%) Query: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649 K+ +L LD + HKI + Y GQ + + +NE A+E+F+ LG V L Sbjct: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689 Query: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708 + L + STG + Y E++FHVST +P ++ L +K RH+GND V Sbjct: 1690 HCGFMGGL-QRNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746 Query: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768 IV+ E + + I + F V +I+ +N + + +++ +VP FGP + Sbjct: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAI 1801 Query: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEN 815 K + + A INA A R YL+ + +N Sbjct: 1802 VSGK--LLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQN 1846 >gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] Length = 1740 Score = 66.6 bits (161), Expect = 2e-10 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%) Query: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644 N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+ Sbjct: 1455 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1514 Query: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701 + LK + L D G +T ++M FH++TL+P ++ + +KRH Sbjct: 1515 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1573 Query: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735 +GND V+IV+ + G F +I+ F V VIV Sbjct: 1574 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1606 >gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] Length = 1807 Score = 66.6 bits (161), Expect = 2e-10 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%) Query: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644 N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+ Sbjct: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581 Query: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701 + LK + L D G +T ++M FH++TL+P ++ + +KRH Sbjct: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640 Query: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735 +GND V+IV+ + G F +I+ F V VIV Sbjct: 1641 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1673 >gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] Length = 1784 Score = 66.6 bits (161), Expect = 2e-10 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%) Query: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644 N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+ Sbjct: 1499 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1558 Query: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701 + LK + L D G +T ++M FH++TL+P ++ + +KRH Sbjct: 1559 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1617 Query: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735 +GND V+IV+ + G F +I+ F V VIV Sbjct: 1618 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1650 >gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens] Length = 1747 Score = 48.9 bits (115), Expect = 4e-05 Identities = 58/243 (23%), Positives = 89/243 (36%), Gaps = 69/243 (28%) Query: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLR---TSVTVKVVII--QPHDD 1027 DVE G AW+AGLR G L+E+ V V + H+Q++ L+R + +KVV + +P +D Sbjct: 630 DVE--GVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEED 687 Query: 1028 GSPRRGCSELCRIPMVEYKLDSEGTPCEYK------------------------------ 1057 G+ RR R P L S+ E + Sbjct: 688 GARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIA 747 Query: 1058 ------TPFRRNTTWHRVPTPALQPLSRASPIPGTPDRLP---------------CQQLL 1096 ++ T R+ + L +PG P++LP ++L Sbjct: 748 DADSRAATVKQRPTSRRITPAEISSLFERQGLPG-PEKLPGSLRKGIPRTKSVGEDEKLA 806 Query: 1097 QQAQAAIPRSTSFDRKLPDGTRSSPSNQSS----------SSDPGPGGSGPWRPQVGYDG 1146 + PRSTS + +G P Q++ S P P S P P YD Sbjct: 807 SLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDT 866 Query: 1147 CQS 1149 +S Sbjct: 867 VRS 869 Score = 31.6 bits (70), Expect = 7.0 Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 2/58 (3%) Query: 1080 ASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLP-DGTRSSPSNQSSSSDPGPGGSG 1136 ASP P LP Q LLQ+ Q R D++ G + + QS SDPGPG G Sbjct: 387 ASPGPSLRS-LPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISDPGPGPGG 443 >gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] Length = 1301 Score = 48.5 bits (114), Expect = 6e-05 Identities = 61/261 (23%), Positives = 92/261 (35%), Gaps = 16/261 (6%) Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174 D + SS SN SS+S S D S + S + + + D+ Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837 Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234 +S ++ GS + + + D S + S + S SS SS + SSN+S Sbjct: 838 SSDSSDSS-----DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892 Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294 +SD + D D + S+DS + S S S + Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS-----------DNSNSSDSSNS 941 Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA 1354 +D++D S D S + S+ S S + S S S S S+ Sbjct: 942 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001 Query: 1355 HCSKSSGSLDSSKVYIVSHSS 1375 + S SS S DSS S SS Sbjct: 1002 NSSDSSDSSDSSDSSNSSDSS 1022 Score = 47.8 bits (112), Expect = 9e-05 Identities = 75/318 (23%), Positives = 114/318 (35%), Gaps = 28/318 (8%) Query: 1105 RSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECD 1164 +S S D D + SS S+ SS SD S D S S + Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605 Query: 1165 GAREREDTMEASRHPETKWHGPPSKVLGS------------YKERALQKDGSCKDSPNKL 1212 + + D+ ++S ++K S+ S + + D S + + Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665 Query: 1213 SHIGDKSCSSHSSSNTLSSNTSSNSDDKHFG----SGDLMDPELLGLTYIKGASTDSGID 1268 S D S SS SSS++ SSN+S +SD S D D + +S + D Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725 Query: 1269 TAPCMPATILGPVHLA----------GSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHG 1318 + + + + S S S + +D++D S D S Sbjct: 726 SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785 Query: 1319 YASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHS--SG 1376 S+ S+ S+ + D S S S S S S S++ S SS S DSS S S S Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS 845 Query: 1377 QQVPGSMSKPYHRQGAVN 1394 GS S +R + N Sbjct: 846 DSSDGSDSDSSNRSDSSN 863 Score = 42.4 bits (98), Expect = 0.004 Identities = 65/263 (24%), Positives = 98/263 (37%), Gaps = 8/263 (3%) Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174 D + SS S++SS+S S D S + S D + + + Sbjct: 916 DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS----DSSNSSDSSDS 971 Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234 S + S + + D S + S D S SS SS+++ SSN+S Sbjct: 972 NSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSS 1031 Query: 1235 SNSDDKHFG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSR 1293 +SD S D D + S+DS D++ ++ S S S Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS-DSSDSSDSSDSSD-SSDSSESSDSSD 1089 Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSP 1352 + +D++D S D S S+ S+ S+ D S+ S S+ S S S Sbjct: 1090 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSE 1149 Query: 1353 SAHCSKSSGSLDSSKVYIVSHSS 1375 S+ S SS S DSS S SS Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDSS 1172 Score = 40.4 bits (93), Expect = 0.015 Identities = 61/253 (24%), Positives = 93/253 (36%), Gaps = 26/253 (10%) Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174 D + SS S+ SS S S D S S + + + D+ E Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS--------SDSSDSSDSSDSSDSSE 1083 Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234 +S ++ + S + + D S + S+ D S SS SS ++ SSN+S Sbjct: 1084 SSDSSDSS-NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142 Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294 +SD S D D + S+DS + S S S + Sbjct: 1143 DSSDSSE--SSDSSDSSDSSDSSDSSDSSDSSDSS--------------DSSNSSDSSDS 1186 Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSPS 1353 +D++D S D S S+ S+ S+ D S+ + S S S S S Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246 Query: 1354 AHCSKSSGSLDSS 1366 ++ S SS S DSS Sbjct: 1247 SNSSDSSDSSDSS 1259 Score = 38.5 bits (88), Expect = 0.057 Identities = 59/261 (22%), Positives = 94/261 (36%), Gaps = 21/261 (8%) Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174 D + SS S+ S SSD S D S + S + + + D+ + Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS--DSSNSSDSSDSSD 760 Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234 +S ++ S D S N S+ D S SS+SS SSN+S Sbjct: 761 SSNSSDSSDSSDSSD----------SSDSSNSSDSNDSSNSSDSSDSSNSSD---SSNSS 807 Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294 +SD D + + S+DS + + + S S S + Sbjct: 808 DSSDSSDSSDSDSSN------SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861 Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA 1354 +D++D S + S S+ S+ S+ + D S +S S S+ Sbjct: 862 SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921 Query: 1355 HCSKSSGSLDSSKVYIVSHSS 1375 S+SS S D+S S+SS Sbjct: 922 DSSESSNSSDNSNSSDSSNSS 942 Score = 36.2 bits (82), Expect = 0.28 Identities = 61/282 (21%), Positives = 99/282 (35%), Gaps = 49/282 (17%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME- 1174 G +S P N+ S+ G + +D QG P D + +D Sbjct: 427 GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSM------QGDDPNSSDESNGNDDANSE 480 Query: 1175 ----ASRHPETKWHGPPSKVLGSYKERALQKD-----------------GSCKDSPNKLS 1213 +S + ++ SK G+ + +D G+ + N S Sbjct: 481 SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS 540 Query: 1214 HIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCM 1273 G S S ++ SSN+S +SD S D +S+DS D++ Sbjct: 541 DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD------------SNSSSDS--DSSDSD 586 Query: 1274 PATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSM 1333 + S S S + +D++D S D + +S + S+ S Sbjct: 587 SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD-------SSKSESDSSDSDSK 639 Query: 1334 GDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSS 1375 D S+ +S S + S S++ S SS S DSS S SS Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681 >gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens] Length = 2161 Score = 45.8 bits (107), Expect = 4e-04 Identities = 45/198 (22%), Positives = 81/198 (40%), Gaps = 38/198 (19%) Query: 974 VEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLR---TSVTVKVVIIQPH---DD 1027 V+ G AW+AGLR G L+E+ V + H Q+++++R ++ VKVV++ H D+ Sbjct: 705 VDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDE 764 Query: 1028 GSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTP 1087 ++ + R+P L S+ E + ++ + +P+P Sbjct: 765 AVHKKAPQQAKRLPPPTISLRSKSMTSELE---------------EMEYEQQPAPVPSME 809 Query: 1088 DRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGG---SGPWRPQVGY 1144 + Q+ KL + ++ S+S PGPGG G RP+ G+ Sbjct: 810 KKRTVYQMAL-------------NKLDEILAAAQQTISASESPGPGGLASLGKHRPK-GF 855 Query: 1145 DGCQSPLLLEHQGSGPLE 1162 +S H+ E Sbjct: 856 FATESSFDPHHRAQPSYE 873 >gi|119829187 alpha 1 type XVII collagen [Homo sapiens] Length = 1497 Score = 43.5 bits (101), Expect = 0.002 Identities = 65/252 (25%), Positives = 97/252 (38%), Gaps = 34/252 (13%) Query: 1310 PAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSPSAHCSKSSGSLDSSKV 1368 P K + +GYA T S G GS + ++ SSG +S GS H S SS Sbjct: 31 PPKGGTSNGYAKTASLGG---GSRLEKQSLTHGSSGYINSTGSTRGHASTSS-------- 79 Query: 1369 YIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMS 1428 Y +HS +P S + R+ V ++ S G+ PE P E S Sbjct: 80 YRRAHSPASTLPNSPGSTFERKTHVTRHAYE-GSSSGNSSPEYPR--------KEFASSS 130 Query: 1429 TATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLS 1488 T + QT + Q + + L D + +G R S +SP R+ TL Sbjct: 131 TRGRSQTRESEIRVRLQSASPSTRWTE--LDDVKRLLKGSRSAS----VSPTRNSSNTLP 184 Query: 1489 -------DESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGS 1541 + I + S G+ +++LD LP+ + ST P S + S Sbjct: 185 IPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTTQSSS 244 Query: 1542 LRNEFWFSDGSL 1553 L N +S GS+ Sbjct: 245 LLNTNAYSAGSV 256 >gi|148727255 microtubule associated serine/threonine kinase family member 4 isoform a [Homo sapiens] Length = 2434 Score = 43.1 bits (100), Expect = 0.002 Identities = 53/186 (28%), Positives = 78/186 (41%), Gaps = 25/186 (13%) Query: 970 IVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGS 1029 IV +VE A +AGL+ G + I V L H ++I+LL S + P ++ S Sbjct: 984 IVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTS 1043 Query: 1030 ----PRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPAL----------Q 1075 P R S R+ K + + ++ F++ + P+P L + Sbjct: 1044 IKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLA---KQPSPLLHTSRSFSCLNR 1100 Query: 1076 PLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDP-GPGG 1134 LS +PG+ P L ++ RST P GT SS S+ SSS P P G Sbjct: 1101 SLSSGESLPGS----PTHSLSPRSPTPSYRSTP---DFPSGTNSSQSSSPSSSAPNSPAG 1153 Query: 1135 SGPWRP 1140 SG RP Sbjct: 1154 SGHIRP 1159 Score = 31.2 bits (69), Expect = 9.1 Identities = 24/97 (24%), Positives = 42/97 (43%), Gaps = 5/97 (5%) Query: 1320 ASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA----HCSKSSGSLDSSKVYIVSHSS 1375 AS S+ +++ + G + E+ + S+ H P+ H +KS SL S +V + S Sbjct: 2286 ASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSD-SLPSFRVSTLPLES 2344 Query: 1376 GQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEP 1412 P +M HR A++ + P P +P Sbjct: 2345 HHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQP 2381 >gi|31742501 sorting nexin family member 27 [Homo sapiens] Length = 528 Score = 42.7 bits (99), Expect = 0.003 Identities = 22/59 (37%), Positives = 38/59 (64%), Gaps = 3/59 (5%) Query: 971 VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRT---SVTVKVVIIQPHD 1026 V+ V P G A +AG+R+G R++E+ V V TH+Q++DL+R + + V+ + PH+ Sbjct: 81 VSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHE 139 >gi|169173184 PREDICTED: hypothetical protein [Homo sapiens] Length = 1230 Score = 41.6 bits (96), Expect = 0.007 Identities = 84/350 (24%), Positives = 118/350 (33%), Gaps = 45/350 (12%) Query: 1113 LPDGTRSSPSNQSSSSDPGPGGSGP---WRPQVGYDGCQSPLLLEHQGSGPL---ECDGA 1166 +P +SPS +S+ G + P W G SP S GA Sbjct: 126 IPSAFWASPSASGASTPSDSGWASPSASWASTSSDSGWASPSASWTSPSASCASSSASGA 185 Query: 1167 REREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCS--SHS 1224 D+ AS P W P + S SP+ S S + S Sbjct: 186 STPSDSGWAS--PSVFWVSPST---------------SWASSPSDFGWASTPSDSGWASS 228 Query: 1225 SSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLA 1284 S++ +S + S S G + T S+DSG ++ +I Sbjct: 229 SASCISPSASGASTSSDSGWASPSASWVSTSTSRASTSSDSGWASSSASWDSITSDSGWV 288 Query: 1285 GSRSLIHSRAEQWADAADVSG---PDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISS 1341 + S + WA A SG P A SV G+AS ++G++A G S +S Sbjct: 289 CPSASWASSSASWASAPSDSGSSSPSVSRASTLSVSGWASFSASGASAPSDSGWTSHSAS 348 Query: 1342 HSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGW- 1400 S + SG S S +S S D SG P + GA GW Sbjct: 349 GVSTTSDSGWASPSASGASTSSD----------SGWASPSASWASPSASGASTPSDSGWA 398 Query: 1401 -KKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLS 1449 + G+ P P + CPG TA TVVG + H +S Sbjct: 399 SPSASGASMPSAPSL--CPG---SCFPQLTARTGFTVVGFPFSLLSHCIS 443 >gi|57864582 hornerin [Homo sapiens] Length = 2850 Score = 41.2 bits (95), Expect = 0.009 Identities = 102/419 (24%), Positives = 141/419 (33%), Gaps = 72/419 (17%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYD-GCQSPLLLEHQGSGPLECDGAREREDTME 1174 G S S QSSS P GSG + Y+ G L HQ S + G + + Sbjct: 546 GRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSG 605 Query: 1175 AS----RHPETK-------WHGPPSKVLGSY---------KERALQKDGSCKDSPNKLSH 1214 S +H T HG S S+ R Q+ SP++ H Sbjct: 606 HSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRH 665 Query: 1215 IGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMP 1274 D SS + S SS++ SG + G + G+ SG Sbjct: 666 GSDFGHSSSYGQHGSGSGWSSSNGPHGSVSG-----QSSGFGHKSGSGQSSGYSQHGSGS 720 Query: 1275 ATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-M 1333 + G GSRS SR+EQ ++ +S Y HG S S+G +GS Sbjct: 721 SHSSG-YRKHGSRSGQSSRSEQHGSSSGLSSS-------YGQHGSGSHQSSGHGRQGSGS 772 Query: 1334 GDLSEISSHSSGSHHSGSPSAH-----CSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYH 1388 G H S S HS S H CS S G +S + GQ GS + Y Sbjct: 773 GHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQ--ASGFGQHESGS-GQGYS 829 Query: 1389 RQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVL 1448 + G+ + G S+G S S++ QH + G + + QH Sbjct: 830 QHGSAS----GHFSSQGRHG-------------STSGQSSSSGQHDSSSGQSSSYGQHES 872 Query: 1449 SKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRSS 1507 + GR + SP + S +S R GS G S SS Sbjct: 873 ASHH------------ASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSS 919 Score = 41.2 bits (95), Expect = 0.009 Identities = 71/284 (25%), Positives = 96/284 (33%), Gaps = 29/284 (10%) Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173 G S S+QSSS GSG P R + G S +H R + Sbjct: 1807 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 1866 Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228 ++S H + W G GS + ++ GS ++ G S SS S Sbjct: 1867 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQH 1926 Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288 S + S +H GSG P + G+ S GP S Sbjct: 1927 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSY-----------GPYGSGSGWS 1974 Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347 E + + G + + S +G + S S+ G G S SS S G H Sbjct: 1975 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSS-SCGQHG 2033 Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390 SG S+H SGS SS G+Q GS P H Q Sbjct: 2034 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 2070 Score = 38.9 bits (89), Expect = 0.044 Identities = 70/284 (24%), Positives = 95/284 (33%), Gaps = 29/284 (10%) Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173 G R S S+QSS GSG P R + G S +H R + Sbjct: 1337 GHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 1396 Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228 ++S H + W G GS + ++ GS ++ G S SS S Sbjct: 1397 QSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 1456 Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288 S + S +H GSG P + G+ S P S Sbjct: 1457 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSYS-----------PYGSGSGWS 1504 Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347 E + + G + + S +G + S S+ G G S SS S G H Sbjct: 1505 SSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSS-SCGQHG 1563 Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390 SG S+H SGS SS G+Q GS P H Q Sbjct: 1564 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 1600 Score = 38.9 bits (89), Expect = 0.044 Identities = 70/284 (24%), Positives = 95/284 (33%), Gaps = 29/284 (10%) Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173 G S S+QSSS GSG P R + G S +H R + Sbjct: 2277 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336 Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228 ++S H + W G GS + ++ GS ++ G S SS S Sbjct: 2337 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 2396 Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288 S + S +H GSG P + G+ S P S Sbjct: 2397 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSYS-----------PYGSGSGWS 2444 Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347 E + + G + + S +G + S S+ G G S SS S G H Sbjct: 2445 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSS-SCGQHG 2503 Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390 SG S+H SGS SS G+Q GS P H Q Sbjct: 2504 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 2540 Score = 37.4 bits (85), Expect = 0.13 Identities = 77/311 (24%), Positives = 100/311 (32%), Gaps = 68/311 (21%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175 G S S SSS+ P SG G GSG G R+ Sbjct: 676 GQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQ 735 Query: 1176 SRHPETKWHGPPSKVLGSYKERAL---QKDGSCKD------SPNKLSHIGDKSCSSHSSS 1226 S E HG S + SY + Q G + SP+++ H S S HSSS Sbjct: 736 SSRSEQ--HGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRH---GSSSGHSSS 790 Query: 1227 NTL-SSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAG 1285 + S TS +S H+ SG G ++ G H +G Sbjct: 791 HGQHGSGTSCSSSCGHYESGS-------------GQASGFG--------------QHESG 823 Query: 1286 SRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSS 1344 S + ++ SG + HG S S+ S + S G S H S Sbjct: 824 S-------GQGYSQHGSASGHFSSQGR----HGSTSGQSSSSGQHDSSSGQSSSYGQHES 872 Query: 1345 GSHH----------SGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVN 1394 SHH SG H + SGS S SG+ S S H G+ Sbjct: 873 ASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGR----SSSSGRHGSGSGQ 928 Query: 1395 KYVIGWKKSEG 1405 G K S G Sbjct: 929 SSGFGHKSSSG 939 Score = 37.4 bits (85), Expect = 0.13 Identities = 29/77 (37%), Positives = 34/77 (44%), Gaps = 3/77 (3%) Query: 1317 HGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSS- 1375 HG S S+G + S G S + H SGS HS S H S+S S S + S SS Sbjct: 922 HGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSS 981 Query: 1376 --GQQVPGSMSKPYHRQ 1390 GQ GS H Q Sbjct: 982 SYGQHGSGSRQSLGHGQ 998 Score = 37.4 bits (85), Expect = 0.13 Identities = 90/366 (24%), Positives = 120/366 (32%), Gaps = 61/366 (16%) Query: 1116 GTRSSPSNQS--------SSSDPGPGGSGPWRP----QVGYDGCQSPLLLEHQ---GSGP 1160 G+RS S++S SSS G GSG + Q G QSP + GSG Sbjct: 961 GSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQ 1020 Query: 1161 LECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDK 1218 G +SR P G S LG + R+ Q G + S S G Sbjct: 1021 SSSYGPYRSGSGWSSSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1079 Query: 1219 SCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATIL 1278 +S SS+ SS H G G+S SG Sbjct: 1080 GSTSGQSSSCGQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ-- 1124 Query: 1279 GPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLS 1337 P H G R ++ + SG + HG S+G E S G S Sbjct: 1125 SPGH--GQRGSGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSS 1178 Query: 1338 EISSHSSGSHHSGSPSAHCSKSS--------GSLDSSKVYIVSHSSGQQVPGSMSKPYHR 1389 S H SGS HS H S+S GS S + H SG + S + R Sbjct: 1179 SYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR----QSSGHGR 1234 Query: 1390 QGAVNKYV---------IGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440 QG+ + + +G S G + S S QH++ G + Sbjct: 1235 QGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS 1294 Query: 1441 VAETQH 1446 A +QH Sbjct: 1295 SAYSQH 1300 Score = 37.0 bits (84), Expect = 0.17 Identities = 98/404 (24%), Positives = 132/404 (32%), Gaps = 80/404 (19%) Query: 1116 GTRSSPSNQSSSSD---PGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDG--ARERE 1170 G S S QSSS+D G G S + G S GSG G Sbjct: 206 GQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSG 265 Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLS 1230 + RH + GS ++L S SH+ S S HSSS+ Sbjct: 266 QSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQH 325 Query: 1231 SNTSSNSDDK-HFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSL 1289 + SS S + H+ SG G ++ G H +GS Sbjct: 326 GSGSSYSYSRGHYESG-------------SGQTSGFG--------------QHESGS--- 355 Query: 1290 IHSRAEQWADAADVSGPDDEPAKLYSVHGYASTI---SAGSAAEGSMGDLSEISSHSSG- 1345 ++ ++ SG + S G AS+ + S S G S HSSG Sbjct: 356 --GQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGR 413 Query: 1346 ---SHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKK 1402 S SG H + SGS S SSGQ G + R + YV G Sbjct: 414 GQHSSGSGQSPGHGQRGSGSGQSP-------SSGQHGTG-----FGRSSSSGPYVSGSGY 461 Query: 1403 SEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSP 1462 S G E S + S TQH + G + QH S Sbjct: 462 SSGFGHHE-----------SSSEHSSGYTQHGSGSGHSSGHGQHG-----------SRSG 499 Query: 1463 LVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRS 1506 G R+ S G+ S + + S +S+ +R GS G S S Sbjct: 500 QSSRGERQGSSAGS-SSSYGQHGSGSRQSLGHSRHGSGSGQSPS 542 Score = 36.6 bits (83), Expect = 0.22 Identities = 59/213 (27%), Positives = 74/213 (34%), Gaps = 23/213 (10%) Query: 1314 YSVHGYASTISAGSAAEGSMGDLSEI---------SSHSSGSHHSGSPSA--HCSKSSGS 1362 YS HG S S+G GS S SS S G H SGS + H + SGS Sbjct: 244 YSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGS 303 Query: 1363 LDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYS 1422 S V H SG S S H G+ Y G +S + G S Sbjct: 304 RQSPS--HVRHGSGS--GHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSS 359 Query: 1423 EMDV-------MSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDS-PLVEEGRRKFSFY 1474 S+ QH + G A + QH S +S GR + S Sbjct: 360 GYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSG 419 Query: 1475 GNLSPRRSLYRTLSDESICSNRRGSSFGSSRSS 1507 SP + S +S S + G+ FG S SS Sbjct: 420 SGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSS 452 Score = 36.6 bits (83), Expect = 0.22 Identities = 74/281 (26%), Positives = 99/281 (35%), Gaps = 29/281 (10%) Query: 1122 SNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPET 1181 S+ SSS G GSG R +G+ S G P G E +S Sbjct: 509 SSAGSSSSYGQHGSGS-RQSLGHSRHGSG-----SGQSPSPSRGRHESGSRQSSS----- 557 Query: 1182 KWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKH 1241 +GP G R + GS S L H +S S SS+ S++ +H Sbjct: 558 --YGPHGYGSGRSSSRGPYESGSGHSSG--LGHQESRSGQSSGYGQHGSSSGHSSTHGQH 613 Query: 1242 FG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADA 1300 SG G T G S+ G + ++ G +S SR +D Sbjct: 614 GSTSGQSSSCGQHGAT--SGQSSSHGQHGSGSSQSSRYGQQGSGSGQS--PSRGRHGSDF 669 Query: 1301 ADVS-----GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAH 1355 S G + HG S S+G + G S S H SGS HS H Sbjct: 670 GHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKH 729 Query: 1356 CSKSSGSLDSSK---VYIVSHSSGQQVPGS-MSKPYHRQGA 1392 S+S S S + +S S GQ GS S + RQG+ Sbjct: 730 GSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGS 770 Score = 36.2 bits (82), Expect = 0.28 Identities = 66/279 (23%), Positives = 90/279 (32%), Gaps = 31/279 (11%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175 G R S S QS S GSG + G P L E G G E + + Sbjct: 2069 GQRGSGSRQSPSYGRHGSGSG----RSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHG 2124 Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235 S + +G G ++ GS S ++ G S S S + S Sbjct: 2125 SGSGHSSGYGQHGSRSGQSSRG--ERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHS 2182 Query: 1236 NSDDKH-FGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGP------------VH 1282 S +H GSG G G S+ G + +++ G H Sbjct: 2183 PSRGRHGSGSGHSSSHGQHGSG--SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQH 2240 Query: 1283 LAGSRSLI----HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDLS 1337 +GS H + D G + + HG S+ S+ +GS G Sbjct: 2241 GSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSP 2300 Query: 1338 EISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSG 1376 H SGS HS S H S S S S + H SG Sbjct: 2301 SRGRHGSGSGHSSSYGQHGSGSGWSSSSGR-----HGSG 2334 Score = 35.8 bits (81), Expect = 0.37 Identities = 72/302 (23%), Positives = 95/302 (31%), Gaps = 26/302 (8%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175 G+ SPS G G S + P G S GSG G RE + Sbjct: 2412 GSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSS 2471 Query: 1176 --SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSS-NTLSSN 1232 +H + H GS ++ S SH S SS SS S Sbjct: 2472 GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSG 2531 Query: 1233 TSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLI-- 1290 + + GSG P G S+ SG + ++ G + +S Sbjct: 2532 SGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYS 2591 Query: 1291 --------------HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGD 1335 H + + G + Y HG S S+G +GS G Sbjct: 2592 QHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQ 2651 Query: 1336 LSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVY--IVSHSS--GQQVPGS-MSKPYHRQ 1390 H SG HS S H S SG S Y + HSS GQ GS S Y + Sbjct: 2652 SPSRGRHGSGLGHSSSHGQHGS-GSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710 Query: 1391 GA 1392 G+ Sbjct: 2711 GS 2712 Score = 35.0 bits (79), Expect = 0.63 Identities = 77/285 (27%), Positives = 95/285 (33%), Gaps = 36/285 (12%) Query: 1122 SNQSSSSDPGPGGSGPWRP----QVGYDGCQSPLLLEHQ---GSGPLECDGAREREDTME 1174 S+ SSS G GSG + Q G QSP + GSG G Sbjct: 1915 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWS 1974 Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNTLSSN 1232 +SR P G S LG + R+ Q G + S S G +S SS+ Sbjct: 1975 SSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHG 2033 Query: 1233 TSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHS 1292 SS H G G+S SG P H G R Sbjct: 2034 ASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRGSGSR 2076 Query: 1293 RAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSHHSGS 1351 ++ + SG + HG S+G E S G S S H SGS HS Sbjct: 2077 QSPSYGRHGSGSGRSSSSGQ----HGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2132 Query: 1352 PSAHCSKSSGSLDSSKVYIVSHSS---GQQVPGSMSKPYH-RQGA 1392 H S+S S + S SS GQ GS H RQG+ Sbjct: 2133 YGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGS 2177 Score = 35.0 bits (79), Expect = 0.63 Identities = 86/356 (24%), Positives = 112/356 (31%), Gaps = 67/356 (18%) Query: 1111 RKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERE 1170 + L G S S QS S G GSG G SP GSG Sbjct: 2402 QSLGHGQHGSGSGQSPSPSRGRHGSGS-----GQSSSYSPY-----GSG----------- 2440 Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNT 1228 +SR P G S LG + R+ Q G + S S G +S SS+ Sbjct: 2441 SGWSSSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 2499 Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288 SS H G G+S SG P H G R Sbjct: 2500 GQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRG 2542 Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSH 1347 ++ + SG + HG S+G E S G S S H SGS Sbjct: 2543 SGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 2598 Query: 1348 HSGSPSAHCSKSS--------GSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYV-- 1397 HS H S+S GS S + H SG + S + RQG+ + Sbjct: 2599 HSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR----QSSGHGRQGSGSGQSPS 2654 Query: 1398 -------IGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQH 1446 +G S G + S + S QH++ G + A +QH Sbjct: 2655 RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710 Score = 34.7 bits (78), Expect = 0.82 Identities = 74/300 (24%), Positives = 93/300 (31%), Gaps = 32/300 (10%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVG-YDGCQSPLLLEHQGSGPLECDGAREREDTME 1174 G S S QSSS P GSG W G Y+ S G G E + Sbjct: 1482 GRHGSGSGQSSSYSPYGSGSG-WSSSRGPYESGSS----HSSGLGHRESRSGQSSGYGQH 1536 Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSS-NTLSSNT 1233 S + HG G S + S SH S SS SS S + Sbjct: 1537 GSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSS----SHGQHGSGSSQSSGYGRQGSGS 1592 Query: 1234 SSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLI--- 1290 + GSG P G S+ SG + ++ G + +S Sbjct: 1593 GQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQ 1652 Query: 1291 -------------HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDL 1336 H + + G + Y HG S S+G +GS G Sbjct: 1653 HGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQS 1712 Query: 1337 SEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVS-HSS--GQQVPGS-MSKPYHRQGA 1392 H SG HS S H S S S S HSS GQ GS S Y + G+ Sbjct: 1713 PSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS 1772 Score = 34.3 bits (77), Expect = 1.1 Identities = 77/289 (26%), Positives = 92/289 (31%), Gaps = 50/289 (17%) Query: 1111 RKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERE 1170 + L G S S QS S G GSG G SP GSG G E Sbjct: 1462 QSLGHGQHGSGSGQSPSPSRGRHGSGS-----GQSSSYSPY---GSGSGWSSSRGPYE-- 1511 Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNT 1228 S H S LG + R+ Q G + S S G +S SS+ Sbjct: 1512 ---SGSSH---------SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 1559 Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288 SS H G G+S SG P H G R Sbjct: 1560 GQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRG 1602 Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSH 1347 ++ + SG + HG S+G E S G S S H SGS Sbjct: 1603 SGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 1658 Query: 1348 HSGSPSAHCSKSSGSLDSSKVYIVSHSS---GQQVPGSMSKPYH-RQGA 1392 HS H S+S S + S SS GQ GS H RQG+ Sbjct: 1659 HSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGS 1707 Score = 33.5 bits (75), Expect = 1.8 Identities = 67/275 (24%), Positives = 92/275 (33%), Gaps = 27/275 (9%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERED---- 1171 G+R SPS+ S G S Q G G H SG + G + E Sbjct: 302 GSRQSPSHVRHGSGSGHSSS---HGQHG-SGSSYSYSRGHYESGSGQTSGFGQHESGSGQ 357 Query: 1172 TMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSS 1231 + S+H H GS +A S S+ +S S HSS S Sbjct: 358 SSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHS 417 Query: 1232 NTSSNSD---DKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288 + S S + GSG G + G S+ SG + G + +G Sbjct: 418 SGSGQSPGHGQRGSGSGQSPSSGQHGTGF--GRSSSSG--------PYVSGSGYSSGFGH 467 Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSM-GDLSEISSHSSGSH 1347 H + + + G + + HG S S+ +GS G S H SGS Sbjct: 468 --HESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSR 525 Query: 1348 HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGS 1382 S S H S S S S+ H SG + S Sbjct: 526 QSLGHSRHGSGSGQSPSPSR---GRHESGSRQSSS 557 Score = 32.7 bits (73), Expect = 3.1 Identities = 63/264 (23%), Positives = 85/264 (32%), Gaps = 40/264 (15%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175 G S S QSSS GSG GY +H G R + + Sbjct: 1638 GHHESSSGQSSSYSQHGSGSGH---SSGYG--------QHGSRSGQSSRGERHGSSSRSS 1686 Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSH-IGDKSCSSHSSSNTLSSNTS 1234 SR+ + HG S+ + Q GS + SP++ H G SSH + S +S Sbjct: 1687 SRYGQ---HGSGSRQSSGHGR---QGSGSGQ-SPSRGRHGSGLGHSSSHGQHGSGSGRSS 1739 Query: 1235 SNSD-DKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSR 1293 S + G + G + S G H H Sbjct: 1740 SRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS------------GSGHFCSQGQ--HGS 1785 Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDLSEISSHSSGSHHSGSP 1352 + D G + + HG S+ S+ +GS G H SGS HS S Sbjct: 1786 TSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSY 1845 Query: 1353 SAHCSKSSGSLDSSKVYIVSHSSG 1376 H S S S S + H SG Sbjct: 1846 GQHGSGSGWSSSSGR-----HGSG 1864 Score = 32.0 bits (71), Expect = 5.3 Identities = 44/162 (27%), Positives = 54/162 (33%), Gaps = 21/162 (12%) Query: 1291 HSRAEQWADAADVS-GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS 1349 H + W + G + Y HG S G ++ G S SS S G H S Sbjct: 1403 HHESSSWQSSGCTQHGSGSGHSSSYEQHGSRS----GQSSRGERHGSSSGSSSSYGQHGS 1458 Query: 1350 GSPSA--HCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSP 1407 GS + H SGS S H SG S S PY GW S G Sbjct: 1459 GSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYS-PYGSGS-------GWSSSRG-- 1508 Query: 1408 PPEEPEVTECPGM---YSEMDVMSTATQHQTVVGDAVAETQH 1446 P E + G+ S S QH + G + QH Sbjct: 1509 -PYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1549 Score = 32.0 bits (71), Expect = 5.3 Identities = 78/305 (25%), Positives = 98/305 (32%), Gaps = 31/305 (10%) Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEH-QGSGPLECDGAREREDT 1172 G S S QSS GSG P R + G S +H GSG G E Sbjct: 2160 GQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSG 2219 Query: 1173 MEA--SRHPETKWHGPPSKVLGSYKERALQKD--GSCKDSPNKLSHIGDKS--CSSHSSS 1226 + +H H GS + GS + G + SSH Sbjct: 2220 HSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQH 2279 Query: 1227 NTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGS 1286 + SS +SS GSG P G S+ G + ++ G H +GS Sbjct: 2280 GSGSSQSSSYGQQ---GSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGR-HGSGS 2335 Query: 1287 ---RSLIHSRAEQWADAADVS-GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSH 1342 H + W + G + Y HG S G ++ G S SS Sbjct: 2336 GQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRS----GQSSRGERHGSSSGSSS 2391 Query: 1343 SSGSHHSGSPSA--HCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGW 1400 S G H SGS + H SGS S H SG S S PY GW Sbjct: 2392 SYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYS-PYGSGS-------GW 2443 Query: 1401 KKSEG 1405 S G Sbjct: 2444 SSSRG 2448 Score = 31.6 bits (70), Expect = 7.0 Identities = 69/305 (22%), Positives = 89/305 (29%), Gaps = 57/305 (18%) Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEH------------QGSGPL 1161 G S S+QSS GSG P Q G QSP H GSG Sbjct: 1103 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLG 1162 Query: 1162 ECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCS 1221 E G E + + + HG S Y + + S + H S Sbjct: 1163 ESSGFGHHESS--SGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE----RHGSSSGSS 1216 Query: 1222 SHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPV 1281 SH + S SS + GSG G G S+ G + ++ GP Sbjct: 1217 SHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGL--GHSSSHGQHGSGSGRSSSRGPY 1274 Query: 1282 HLAGSRSLI-----------------------------HSRAEQWADAADVSGPDDEPAK 1312 S + H + D G + Sbjct: 1275 ESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSS 1334 Query: 1313 LYSVHGYASTISAGSAAEGS-MGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIV 1371 Y G S+ S+G G+ G H SGS HS S H S S S S + Sbjct: 1335 SYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGR---- 1390 Query: 1372 SHSSG 1376 H SG Sbjct: 1391 -HGSG 1394 Score = 31.2 bits (69), Expect = 9.1 Identities = 82/329 (24%), Positives = 106/329 (32%), Gaps = 75/329 (22%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175 G S S SS+ GSG + Q +H + +E T ++ Sbjct: 1755 GQHESGSGHSSAYSQHGSGSGHFCSQG-----------QHGSTSGQSSTFDQEGSSTGQS 1803 Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235 S H + HG S SY + Q GS + SP++ H SS + S SS Sbjct: 1804 SSHGQ---HGSGSSQSSSYGQ---QGSGSGQ-SPSRGRHGSGSGHSSSYGQHGSGSGWSS 1856 Query: 1236 NSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAE 1295 +S GSG + G + + +S S T + GSRS SR E Sbjct: 1857 SSGRHGSGSG-----QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE 1911 Query: 1296 QWADAADVS---------------------GPDDEPAKLYSVHGYASTISA-------GS 1327 Q ++ S G P+ HG S S+ GS Sbjct: 1912 QHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGS 1971 Query: 1328 AAEGSMGDLSEISSHSSGSHH-------------SGSPSAHCS----KSSGSLDSSKVYI 1370 S G S HSSG H GS S H S S S SS Sbjct: 1972 GWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQ 2031 Query: 1371 VSHSSGQQVP-------GSMSKPYHRQGA 1392 SSGQ S S Y RQG+ Sbjct: 2032 HGASSGQSSSHGQHGSGSSQSSGYGRQGS 2060 Score = 31.2 bits (69), Expect = 9.1 Identities = 67/250 (26%), Positives = 89/250 (35%), Gaps = 41/250 (16%) Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175 G + S QSSS G GSG + GY QGSG + G +R Sbjct: 2500 GQHGASSGQSSSH--GQHGSGSSQSS-GYG---------RQGSGSGQSPGHGQRGSGSRQ 2547 Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235 S P HG GS + + + GS + H S S S S S + S Sbjct: 2548 S--PSYGRHGS-----GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHS 2600 Query: 1236 NSDDKHFG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSR-SLIHSR 1293 + +H SG E G + G+S+ G H +GSR S H R Sbjct: 2601 SGYGQHGSRSGQSSRGERHGSS--SGSSSHYG--------------QHGSGSRQSSGHGR 2644 Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS----MGDLSEISSHSSGSHHS 1349 + + G S HG + S S++ G +G S H SGS HS Sbjct: 2645 QGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHS 2704 Query: 1350 GSPSAHCSKS 1359 + S H S S Sbjct: 2705 SAYSQHGSGS 2714 >gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] Length = 1397 Score = 40.8 bits (94), Expect = 0.011 Identities = 77/327 (23%), Positives = 123/327 (37%), Gaps = 43/327 (13%) Query: 971 VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSP 1030 V +V+ G A +AGLR G RLV++ +V T+ Q+I L++ S + I P D+ Sbjct: 6 VKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDIL 65 Query: 1031 RRGCSELCRIPMVE-YKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTPDR 1089 + S+ + E Y ++ P + R T P + +RA+ +P Sbjct: 66 QLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY-----APPARASTRATMVPEPTSA 120 Query: 1090 LPCQQLLQQAQAAIPRSTSF----DRKLPDGTRSSPSNQS---SSSDPGPGGSGPWRPQV 1142 LP PRS + ++P R+ N S S P PG P + Sbjct: 121 LPSD----------PRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAF----PHL 166 Query: 1143 GYDGCQSPLLLEHQGS----GPLECDGAREREDTMEASRHP-ETKWHGPPSKVLGSYKER 1197 + ++P GS LEC A + + R E + + + ++R Sbjct: 167 SSEP-RTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDR 225 Query: 1198 ----ALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELL 1253 A + C S + LS +G + S + LS T S + G G L+ P Sbjct: 226 LEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRS---AEALGPGALVSPRFE 282 Query: 1254 GLTYIKGASTDSGIDTAPCMPATILGP 1280 + AS S T C + GP Sbjct: 283 RCGW---ASQRSSARTPACPTRDLPGP 306 >gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] Length = 2752 Score = 40.4 bits (93), Expect = 0.015 Identities = 40/160 (25%), Positives = 60/160 (37%), Gaps = 14/160 (8%) Query: 1082 PIPGTPD----RLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGP 1137 P PG P P QQ A + +R+ + SS S+ SSSS S Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556 Query: 1138 WRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKER 1197 +G S P++ + A +R + + + PP K R Sbjct: 2557 GSSSSDSEG----------SSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRR 2606 Query: 1198 ALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNS 1237 + S S + S S SS SSS++ SS++SS+S Sbjct: 2607 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646 Score = 37.0 bits (84), Expect = 0.17 Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%) Query: 1069 VPTPALQPLSRASPIPGTPDRLPC-----QQLLQQAQAAIPRSTSFDRKLPDGTRSSPSN 1123 VP P + P T + P Q ++ ++ S+S + SS S+ Sbjct: 2496 VPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSS 2555 Query: 1124 QSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKW 1183 SSS G S P +P+V SP P + RE R PE Sbjct: 2556 SGSSSSDSEGSSLPVQPEVALKRVPSPT--------PAPKEAVRE-------GRPPEPT- 2599 Query: 1184 HGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDK 1240 P+K + S S + S S SS SSS++ SS++SS S K Sbjct: 2600 ---PAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAK 2653 Score = 36.2 bits (82), Expect = 0.28 Identities = 76/323 (23%), Positives = 110/323 (34%), Gaps = 66/323 (20%) Query: 1063 NTTWHRVPTPALQPLS-RASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSP 1121 N T RVP A + +S R SP LL +A++ P S ++ SP Sbjct: 2379 NLTSPRVPLSAYERVSGRTSP-----------PLLDRARSRTPPSAPSQSRMTSERAPSP 2427 Query: 1122 SNQS----SSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQG--SGPLECDGAREREDTMEA 1175 S++ S S P P P QS L+ +G T A Sbjct: 2428 SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSA 2487 Query: 1176 SRH-----------PETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHS 1224 H P + PP+ G+ + AL K+ + S S SS S Sbjct: 2488 GDHNGMLSVPAPGVPHSDVGEPPAST-GAQQPSALAALQPAKERRSSSSSSSSSSSSSSS 2546 Query: 1225 SSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLA 1284 SS++ SS++S +S GS + PE+ +P+ P Sbjct: 2547 SSSSSSSSSSGSSSSDSEGSSLPVQPEV----------------ALKRVPSPTPAPKEA- 2589 Query: 1285 GSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSS 1344 + P+ PAK S+ S+ S++ S S SS SS Sbjct: 2590 ---------------VREGRPPEPTPAK----RKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630 Query: 1345 GSHHSGSPSAHCSKSSGSLDSSK 1367 S S S S+ S SS S +K Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAK 2653 Score = 33.1 bits (74), Expect = 2.4 Identities = 35/138 (25%), Positives = 50/138 (36%), Gaps = 9/138 (6%) Query: 1110 DRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPL----LLEHQGSGPLECDG 1165 D+K TR SPS + SS+ P P P + + G PL L + + P E Sbjct: 341 DKKEKSATRPSPSPERSSTGPEPPAPTPLLAE-RHGGSPQPLATTPLSQEPVNPPSEASP 399 Query: 1166 AREREDTMEASRHPE--TKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSH 1223 R+R + P+ + PPS A S K +P SH + SS Sbjct: 400 TRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSH--REISSSP 457 Query: 1224 SSSNTLSSNTSSNSDDKH 1241 +S N + H Sbjct: 458 TSKNRSHGRAKRDKSHSH 475 >gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo sapiens] Length = 358 Score = 39.7 bits (91), Expect = 0.026 Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 6/72 (8%) Query: 962 GFHVNFEG-----IVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSV- 1015 GFH++ E + VEP A KAGL G RLVE+ V TH+Q++ +R ++ Sbjct: 25 GFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALN 84 Query: 1016 TVKVVIIQPHDD 1027 V+++++ P D Sbjct: 85 AVRLLVVDPETD 96 >gi|8923040 CDKN2A interacting protein [Homo sapiens] Length = 580 Score = 38.9 bits (89), Expect = 0.044 Identities = 65/242 (26%), Positives = 96/242 (39%), Gaps = 26/242 (10%) Query: 1152 LLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSY--KERALQKDGSCKDSP 1209 ++E + S +E D A+ T AS E S +GS E S S Sbjct: 145 VIEGKNSSAVEQDHAKTSAKTERASAQQENS-----STCIGSAIKSESGNSARSSGISSQ 199 Query: 1210 NKLSHIGDKSCSSHSSSNTLSSNTSSNS--------DDKHFGSGDLMDPELLGLTYIKGA 1261 N + GD+S SS SSS+ S T++ S DKH GS + + Sbjct: 200 NSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKH-GSASFVSLLKSSVNSHMTQ 258 Query: 1262 STDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYAS 1321 STDS + + + G S S S +E SG + L S + Sbjct: 259 STDSRQQSGSPKKSALEG-----SSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSE 313 Query: 1322 TISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPG 1381 T S+G ++ S + S SS + S SG+ S KSS S ++S +++ S QV Sbjct: 314 TASSGLTSKTS-SEASVSSSVAKNSSSSGT-SLLTPKSSSSTNTS---LLTSKSTSQVAA 368 Query: 1382 SM 1383 S+ Sbjct: 369 SL 370 >gi|45827729 scribble isoform b [Homo sapiens] Length = 1630 Score = 38.9 bits (89), Expect = 0.044 Identities = 58/199 (29%), Positives = 81/199 (40%), Gaps = 54/199 (27%) Query: 968 EGI-VADVEPFGFAWKAG-LRQGSRLVEICKVAVATLTHEQMIDLLRT---SVTVKV--- 1019 EGI ++ V P G A + G LR G RL+E+ + ++ LTH + + LLR+ ++TV V Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191 Query: 1020 --------------VIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTT 1065 VI P G R E I ++ +L EG E + P + Sbjct: 1192 FEASTDAALEVSPGVIANPFAAGIGHRNSLE--SISSIDRELSPEGPGKEKELP-GQTLH 1248 Query: 1066 WHRVPTPA----LQPLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRS-- 1119 W T A LQPL +L +A AA+P + S R +P G Sbjct: 1249 WGPEATEAAGRGLQPL----------------KLDYRALAAVPSAGSVQR-VPSGAAGGK 1291 Query: 1120 ------SPSNQSSSSDPGP 1132 SPS Q S P P Sbjct: 1292 MAESPCSPSGQQPPSPPSP 1310 Score = 37.7 bits (86), Expect = 0.097 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 18/105 (17%) Query: 957 GLGQLGFHVNFEGI-VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSV 1015 G G + + EGI ++ V G A +AG+R G +L+E+ VA+ H + ++ LR + Sbjct: 745 GKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAG 804 Query: 1016 T-----------------VKVVIIQPHDDGSPRRGCSELCRIPMV 1043 T V + ++P DD SPR R+P++ Sbjct: 805 TAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLL 849 Score = 31.2 bits (69), Expect = 9.1 Identities = 24/78 (30%), Positives = 40/78 (51%), Gaps = 6/78 (7%) Query: 963 FHVNFEGI-VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMID-LLRTSVTVKVV 1020 F V G+ ++ V P G A ++GLR G R++ + V TH++ + LLR + + ++ Sbjct: 1029 FGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088 Query: 1021 IIQPHDDGSPRRGCSELC 1038 + D P G ELC Sbjct: 1089 V--RRDPAPP--GLRELC 1102 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.315 0.131 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 70,486,260 Number of Sequences: 37866 Number of extensions: 3506879 Number of successful extensions: 15550 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 61 Number of HSP's successfully gapped in prelim test: 120 Number of HSP's that attempted gapping in prelim test: 14879 Number of HSP's gapped (non-prelim): 688 length of query: 1722 length of database: 18,247,518 effective HSP length: 116 effective length of query: 1606 effective length of database: 13,855,062 effective search space: 22251229572 effective search space used: 22251229572 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.