Guide to the Human Genome
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Search of human proteins with 112421013

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112421013 signal-induced proliferation-associated 1 like 2
[Homo sapiens]
         (1722 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112421013 signal-induced proliferation-associated 1 like 2 [H...  3481   0.0  
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom...  1571   0.0  
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho...  1330   0.0  
gi|206725526 signal-induced proliferation-associated protein 1 [...   617   e-176
gi|206725523 signal-induced proliferation-associated protein 1 [...   617   e-176
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ...   230   1e-59
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ...   230   1e-59
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi...   221   5e-57
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi...   221   5e-57
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi...   221   5e-57
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa...   217   9e-56
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2...    74   9e-13
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1...    74   9e-13
gi|118600961 akt substrate AS250 [Homo sapiens]                        70   1e-11
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]             67   2e-10
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]             67   2e-10
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]             67   2e-10
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap...    49   4e-05
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    49   6e-05
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...    46   4e-04
gi|119829187 alpha 1 type XVII collagen [Homo sapiens]                 44   0.002
gi|148727255 microtubule associated serine/threonine kinase fami...    43   0.002
gi|31742501 sorting nexin family member 27 [Homo sapiens]              43   0.003
gi|169173184 PREDICTED: hypothetical protein [Homo sapiens]            42   0.007
gi|57864582 hornerin [Homo sapiens]                                    41   0.009
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]           41   0.011
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        40   0.015
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s...    40   0.026
gi|8923040 CDKN2A interacting protein [Homo sapiens]                   39   0.044
gi|45827729 scribble isoform b [Homo sapiens]                          39   0.044

>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
            sapiens]
          Length = 1722

 Score = 3481 bits (9025), Expect = 0.0
 Identities = 1722/1722 (100%), Positives = 1722/1722 (100%)

Query: 1    MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG 60
            MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG
Sbjct: 1    MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG 60

Query: 61   GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD 120
            GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD
Sbjct: 61   GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD 120

Query: 121  QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV 180
            QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV
Sbjct: 121  QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV 180

Query: 181  NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI 240
            NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI
Sbjct: 181  NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI 240

Query: 241  SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS 300
            SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS
Sbjct: 241  SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS 300

Query: 301  EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG 360
            EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG
Sbjct: 301  EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG 360

Query: 361  ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG 420
            ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG
Sbjct: 361  ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG 420

Query: 421  DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI 480
            DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI
Sbjct: 421  DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI 480

Query: 481  DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL 540
            DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL
Sbjct: 481  DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL 540

Query: 541  TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE 600
            TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE
Sbjct: 541  TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE 600

Query: 601  QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK 660
            QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK
Sbjct: 601  QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK 660

Query: 661  TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT 720
            TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT
Sbjct: 661  TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT 720

Query: 721  PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL 780
            PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL
Sbjct: 721  PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL 780

Query: 781  LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK 840
            LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK
Sbjct: 781  LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK 840

Query: 841  VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV 900
            VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV
Sbjct: 841  VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV 900

Query: 901  IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ 960
            IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ
Sbjct: 901  IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ 960

Query: 961  LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV 1020
            LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV
Sbjct: 961  LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV 1020

Query: 1021 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA 1080
            IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA
Sbjct: 1021 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA 1080

Query: 1081 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP 1140
            SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP
Sbjct: 1081 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP 1140

Query: 1141 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ 1200
            QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ
Sbjct: 1141 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ 1200

Query: 1201 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG 1260
            KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG
Sbjct: 1201 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG 1260

Query: 1261 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA 1320
            ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA
Sbjct: 1261 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA 1320

Query: 1321 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP 1380
            STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP
Sbjct: 1321 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP 1380

Query: 1381 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440
            GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA
Sbjct: 1381 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440

Query: 1441 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS 1500
            VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS
Sbjct: 1441 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS 1500

Query: 1501 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA 1560
            FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA
Sbjct: 1501 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA 1560

Query: 1561 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH 1620
            DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH
Sbjct: 1561 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH 1620

Query: 1621 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA 1680
            GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA
Sbjct: 1621 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA 1680

Query: 1681 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS 1722
            VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS
Sbjct: 1681 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS 1722


>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
            sapiens]
          Length = 1804

 Score = 1571 bits (4067), Expect = 0.0
 Identities = 929/1874 (49%), Positives = 1185/1874 (63%), Gaps = 227/1874 (12%)

Query: 1    MSDPRQSQEEKH-KLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNET 59
            M+  ++SQ E+     RAS    D    + +DD++ R+F++ NG++G +  +       +
Sbjct: 1    MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSV-MAPVGPPRS 59

Query: 60   GGGGPANGTPAVPKMGVRARVSEWPPKKDCSKELT--CKALWESRSQTSYESITSVLQNG 117
             G      TP VPKMGVRAR+++WPP+K+  KE +   + +  S    S  S +S +  G
Sbjct: 60   EGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQG 119

Query: 118  QSDQSEGQQDEQLDL------------DFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVT 165
             S          L              + +++++ + + +  SP++ L  IRQRSNSD+T
Sbjct: 120  SSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDIT 179

Query: 166  ISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAM 225
            IS++D +   +  +    TG +LHREYGSTSSID+QG SGE+FF +L+GY+ +  D +  
Sbjct: 180  ISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSD-RGP 238

Query: 226  VPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLDYVDSA------LLMGRDRDKPFK 279
             P    +F                I+ G       LD +D        L + ++R+KP K
Sbjct: 239  TPTKLSDFL---------------ITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLK 283

Query: 280  RRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILF 339
            RR KSE+ ++S+FRKLR  K E      +S+LE++R E  +RPW C +CFAHYDVQSILF
Sbjct: 284  RRSKSETGDSSIFRKLRNAKGEE--LGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILF 341

Query: 340  NINEAMATRANVGKRKNITTGASAASQTQM---PTGQTGNCESPLGSKEDLNSKENLDAD 396
            ++NEA+  R NV KR+N TTGASAA+   +   P   + +  SP+GS EDLNSK +L  D
Sbjct: 342  DLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMD 401

Query: 397  EGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVS 456
            +GD KSN+LV+SCPYFRNE GGEG+R+I+LS++NS SFS  ES SFES+LSSHCTNAGV+
Sbjct: 402  QGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVA 461

Query: 457  VLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRRE 516
            VLEVP+EN  +H ++VKRYI+EH+DLGAYYYRKFFY KEH NYFG DENLGPVAVSIRRE
Sbjct: 462  VLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRRE 521

Query: 517  KVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPE 576
            K ++ KE  GS +NYR+ FRTSEL TLRG++LEDAIPSTA+H TARGLPLKEVLE+V+PE
Sbjct: 522  KPDEMKEN-GSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPE 580

Query: 577  LSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEE 636
            L++QCLR A N+PKV+EQL+KLDEQGL++Q K+GI+YCKAGQSTEEEMYNNE+AGPAFEE
Sbjct: 581  LNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEE 640

Query: 637  FLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQL 696
            FL LLG+RVRLKGF KYRAQLD KTDSTGTHSLYTTYKDYE+MFHVST+LPY PNN+QQL
Sbjct: 641  FLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQL 700

Query: 697  LRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKD 756
            LRKRHIGNDIVTIVFQEPGA PF+PK+IRSHFQHVFVIV+VHNPC+++VCYSV V+RS+D
Sbjct: 701  LRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRD 760

Query: 757  VPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENF 816
            VP FGPPIPKGVTFPKS VFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAE  
Sbjct: 761  VPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKN 820

Query: 817  VTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGI 876
            VT   +D S KF FI+L +KKKEK KP   A L S+GAI+W V A D+ ++ +++CLLGI
Sbjct: 821  VTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGI 880

Query: 877  SNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIV 936
            SNEFI+LIE+++K+VVFNCSCRDVIGWTS   S+K+FYERGECV + S  N  E+I+EIV
Sbjct: 881  SNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFIN-IEEIKEIV 939

Query: 937  QRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICK 996
            +RL  V++GCE+VEMTLRRNGLGQLGFHVN+EGIVADVEP+G+AW+AGLRQGSRLVEICK
Sbjct: 940  KRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICK 999

Query: 997  VAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEY 1056
            VAVATL+HEQMIDLLRTSVTVKVVII PHDD +PRR CSE  R+P++EYK+ +EG   E+
Sbjct: 1000 VAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKM-NEGVSYEF 1058

Query: 1057 KTPFRRNTTWHR----------VPTPALQPL-SRASPIPGTPDRLPCQQLLQQAQAAIPR 1105
            K PFR N  W R          VP+    P+ SR +   G     P      +  A IPR
Sbjct: 1059 KFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPP-----PERAANIPR 1113

Query: 1106 STSFD-----RKLPDGT----------------RSSPSNQSSSSDPGPGGSGPWRPQVGY 1144
            S S D     R+L  G+                R+SPSN SSSSD G  G G +R +   
Sbjct: 1114 SISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVG-GTYRQKSMP 1172

Query: 1145 DGC----QSPLLLEHQ-------GSGPLECDGARERED------------------TMEA 1175
            +G     +SP  ++ Q       GSG       R  +                    +E 
Sbjct: 1173 EGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQ 1232

Query: 1176 SRHPETKWHGPP-SKVLGSYKE----RALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLS 1230
              + E   H P  SKVL +++E    R +++D     SPNK  H  D   SSHSSSNTLS
Sbjct: 1233 HEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGH-SDSHYSSHSSSNTLS 1291

Query: 1231 SNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVH-----LAG 1285
            SN SS   D+ +  GD  + EL    Y++G S DSGIDT      T  GP H     L  
Sbjct: 1292 SNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDT------TSYGPSHGSTASLGA 1345

Query: 1286 SRSLIHSR------AEQWADAADVSGPDD--------------EPAKLYSVHGYASTISA 1325
            + S   S       A  W  +++V    D              E +    +H  +   S 
Sbjct: 1346 ATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGST 1405

Query: 1326 GSAAEGSMGDLSEISSHSS--GSHHSGSPSAHCSKSSGSLD-----SSKVYIVSHSSGQQ 1378
                E S   +++ +SH+S   S HS SP    S  S   +     +      S SS   
Sbjct: 1406 PLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSS 1465

Query: 1379 VPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVG 1438
                    Y RQGA +KY+IGWKK EG+               + +  M T  +HQ+  G
Sbjct: 1466 SSSGPRSFYPRQGATSKYLIGWKKPEGT--------------INSVGFMDTRKRHQS-DG 1510

Query: 1439 DAVAETQHVLS----------------KEDFLKLMLPDSPLVEEGRRKFSFYGNLSP--- 1479
            + +A T+   S                +ED  KL+  +SP   E ++ F F+   SP   
Sbjct: 1511 NEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESP-TPESQKSFKFHALSSPQSP 1569

Query: 1480 -------RRSLYRTLSDESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPR 1532
                   RR+L+RTLSDESI +++R   F +SR+S+LDQALPND+LFS+T P      P 
Sbjct: 1570 FPSTPTSRRALHRTLSDESIYNSQR-EHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPL 1628

Query: 1533 AHPAPSMG--SLRNEFWFSDGSLSD-----KSKCADPGLMPLPDTATGLDWTHLVDAARA 1585
              P+ ++G  SL  EF  SD SL+D     +    DPGLMPLPDTA  LDW++LVDAA+A
Sbjct: 1629 RRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKA 1688

Query: 1586 FEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQHGQDLEGAQELPLCVDPGSGKEFMDT 1645
            +E                    + ASF   +D  H + L  A       D    +    +
Sbjct: 1689 YE-------------------VQRASFFAASDENH-RPLSAASNSDQLEDQALAQMKPYS 1728

Query: 1646 TGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATA 1705
            + + S   L  KV+QLE +L+ L+ DL+KEK+DKA LQAEVQHLR+DN+RLQEESQ A+ 
Sbjct: 1729 SSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASD 1788

Query: 1706 QLRKFTEWFFTTID 1719
            +L+KFTEW F TID
Sbjct: 1789 KLKKFTEWVFNTID 1802


>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
            sapiens]
          Length = 1781

 Score = 1330 bits (3443), Expect = 0.0
 Identities = 825/1797 (45%), Positives = 1059/1797 (58%), Gaps = 169/1797 (9%)

Query: 32   DYFARKFKAINGNMGPTTSLNASNSNETGGGG--PANGTPAVPKMGVRARVSEWPPKKDC 89
            DY    F A NG+M      + + +  T      P+  TPA+PKMGVRARV++WPPK++ 
Sbjct: 33   DYAPLGFWAQNGSMSQPLGESPATATATATATTRPSPTTPAMPKMGVRARVADWPPKREA 92

Query: 90   SKELTCKALWESRSQTSYESITSVL---QNGQSDQSEGQQDEQLDLDFVEAKYT----IG 142
             +E +  +  +    T    +   +   QNGQ   S            +  + +      
Sbjct: 93   LREHSNPSPSQDTDGTKATKMAHSMRSIQNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQ 152

Query: 143  DIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQG 202
            D +  SP R   P+R RS+S++T+S+ DAED  +           L REYGSTSSID QG
Sbjct: 153  DGWPRSPGRAFLPLRHRSSSEITLSECDAEDAGEPRGARHTGALPLFREYGSTSSIDVQG 212

Query: 203  LSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLD 262
            +  ++FF +L  +R E  D +        E  R DP   P L      ++G+    +G  
Sbjct: 213  MPEQSFFDILNEFRSEQPDARGCQ--ALTELLRADPG--PHLMGGGGGAKGD--SHNGQP 266

Query: 263  YVDSALLMGRDRDKPFKRRLKS------ESVETSLFRKLRTVKSEHETFKFTSELEESRL 316
              DS L +   ++K   R+  +      ++V++S+FRKLR+ K E E  +   E +E R 
Sbjct: 267  AKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSSIFRKLRSSKPEGEAGRSPGEADEGRS 326

Query: 317  E-RGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPTGQTG 375
                 RPW CQ+ FAH+DVQS+LF++NEA A R +V +R+N TTGASAAS        T 
Sbjct: 327  PPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTA 386

Query: 376  NCESPLG-------SKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSR 428
            +    LG       S EDLN KENL+ D GD  SNDL+LSCP+FRNE GGE +R ++ SR
Sbjct: 387  SRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSR 446

Query: 429  ANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYR 488
            A+  S SSGE    E +LS++ TNA +SVLEVP+E Q   + + ++Y IEH+DLGA YY+
Sbjct: 447  ASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRT-QSRPRQYSIEHVDLGARYYQ 505

Query: 489  KFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAIL 548
             +F GKEH NYFG+DE LGPVAVSI+REK+ED KE  G Q+ YR+ FRT EL TLRG+IL
Sbjct: 506  DYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKE-HGPQYQYRIIFRTRELITLRGSIL 564

Query: 549  EDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHK 608
            EDA P+  +HGT RGLPLK+ LEYVIPEL+I CLR A N+PKV+EQLLKLDEQGL  +HK
Sbjct: 565  EDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHK 624

Query: 609  IGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHS 668
            +GILYCKAGQS+EEEMYNNE AGPAFEEFL L+G++V LKGF+KY AQLD KTDSTGTHS
Sbjct: 625  VGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHS 684

Query: 669  LYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHF 728
            LYT Y+DYE+MFHVSTLLPY PNNRQQLLRKRHIGNDIVTI+FQEPGALPFTPK+IRSHF
Sbjct: 685  LYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHF 744

Query: 729  QHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAE 788
            QHVF+IV+VHNPCT+NVCYS+ V+RSKD PPFGPPIP G TF KS VFRDFLLAKVINAE
Sbjct: 745  QHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAE 804

Query: 789  NAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAH 848
            NAAHKS+KF  MATRTRQEYLKDLAEN V+   +D++ KF+ I+L +KKKEK K R  A 
Sbjct: 805  NAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAE 864

Query: 849  LFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLV 908
              S GAI W V+A+D+ Q  +I+C+LGISNEF++L++  +K VVFNC C DVIGWT    
Sbjct: 865  QHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSS 924

Query: 909  SIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFE 968
            ++K+FY RG+ + L + +   EDIREIVQRL ++T G ETV+MTLRRNGLGQLGFHV ++
Sbjct: 925  TLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYD 984

Query: 969  GIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDG 1028
            G VA+VE +GFAW+AGLRQGSRLVEICKVAV TLTH+QMIDLLRTSVTVKVVII P +DG
Sbjct: 985  GTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDG 1044

Query: 1029 SPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWH---------------RVPTPA 1073
            +PRRG  E   +   E K + E      + P+R N  W                  PT  
Sbjct: 1045 TPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTP 1104

Query: 1074 LQPLSRASPIPGTP--DRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPG 1131
                S + P+  TP       Q L  +   + P  T +        R  P  Q S S   
Sbjct: 1105 GHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFP-ETPYTVSPAGADRVPPYRQPSGSFST 1163

Query: 1132 PGGSGPWRPQVG---YDGCQSPLL-----LEHQG--SGPLECDGAREREDTMEASRHPET 1181
            PG +   R +     Y     PLL       H G  SG     G   +E TME  + PE 
Sbjct: 1164 PGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQK-PEP 1222

Query: 1182 KWHGPP----SKVLGSY-KERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSN-TSS 1235
             WH P     S + GS   +   ++D + KDSPN+ S  G+   SSHSSSNTLSSN +SS
Sbjct: 1223 LWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSK-GEPQYSSHSSSNTLSSNASSS 1281

Query: 1236 NSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTA----------------PCMPATILG 1279
            +SDD+ F   D ++PE   L+  KG S+DSGIDT                 P  P    G
Sbjct: 1282 HSDDRWFDPLDPLEPEQDPLS--KGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPG 1339

Query: 1280 PVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTI--SAGSAAEGSMGDLS 1337
             + L G       R+       +VS     PA      GY   +  S  S   G  G   
Sbjct: 1340 SMGLCGGGREAAGRSHHADRRREVS---PAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSR 1396

Query: 1338 EISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKP-YHRQGAVNKY 1396
            +     S         A   K++ S ++ +   ++  S  Q+  S+ K  + +Q   NK+
Sbjct: 1397 DPPRQPSDMGSRVGYPAQVYKTA-SAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKH 1455

Query: 1397 VIGWKKSEGSPP-------PEEPEVTECPGMYSE-------MDVMSTATQHQTVVGDAVA 1442
              GWK++E  PP       P++   T    ++ +        D+ S    +++ + D   
Sbjct: 1456 PTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIED--- 1512

Query: 1443 ETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFG 1502
                     D  KL++ D+   E+ R         SP++ L RTLSDES+CS RR  SF 
Sbjct: 1513 ---------DLKKLIIMDNLGPEQERDT-----GQSPQKGLQRTLSDESLCSGRREPSFA 1558

Query: 1503 SSRSSVLDQALPNDILFSTTPPY-HSTLPPR---AHPAPSMG------------SLRNEF 1546
            S     L+  LP+D+LF++T  +  STLP R    HP P +G              ++  
Sbjct: 1559 SPAG--LEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTI 1616

Query: 1547 WFSDGSLSD----KSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHT 1602
              S+ SL+D      +  DPGLMPLPDTA GL+W+ LV+AA+A+E               
Sbjct: 1617 SASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYE--------------- 1661

Query: 1603 SYLDQRVASFCTLTDMQHGQDLEGA-----QELPLCVDPGSGKEFMDTTGERSPSPLTGK 1657
                QR  S  +L D     D+  A       L L   P + +    T  E  P  LTGK
Sbjct: 1662 ---VQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRT-TPTMSEEPPLDLTGK 1717

Query: 1658 VNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWF 1714
            V QLE++L+QL TDL+KEKQDK VLQ+EV  LRQ+N RLQEESQ A+ QLRKF E F
Sbjct: 1718 VYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAEIF 1774


>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
            sapiens]
          Length = 1042

 Score =  617 bits (1590), Expect = e-176
 Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%)

Query: 327  RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385
            R FAHYDVQS+LF+     A R+  +G     ++G  A+++ Q                 
Sbjct: 114  RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152

Query: 386  DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445
                            S+DL+   P F  E GGEG+               G        
Sbjct: 153  --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184

Query: 446  LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505
            +     NA VS+LE P+        +   Y +EH DLGA YYRK+FYGKEHQN+FG+DE+
Sbjct: 185  VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237

Query: 506  LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565
            LGPVAVS+RRE+ E +    G+  +YRV  RT++L TLRG I EDA+P     G  RGL 
Sbjct: 238  LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291

Query: 566  LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625
             +++LE+V P+LS  CLR  S SPKV   LL LDEQ LSFQ K+GILYC+AGQ +EEEMY
Sbjct: 292  PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351

Query: 626  NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685
            NN+ AGPAF +FL LLG  VRLKGF  YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+
Sbjct: 352  NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411

Query: 686  LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745
            LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT + 
Sbjct: 412  LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471

Query: 746  CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804
             Y V VSR++D P FGP +P  G  F  +A FR FLLAK +N E AA  + +F AMATRT
Sbjct: 472  TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531

Query: 805  RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863
            RQ+YL+DLA N VTT ++D++ +F   +LG ++  +  PR   A L + G+++W V A  
Sbjct: 532  RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589

Query: 864  FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912
              + A           ++ CLLGIS E ++L+      VVFNC+CRDV+ WT     + +
Sbjct: 590  GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649

Query: 913  FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972
            ++ RGE + L    +  + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V 
Sbjct: 650  YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709

Query: 973  DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032
             VE F FA  AGLR G+RL+ +C   + +L  E    LLR++  V V ++ P + G PRR
Sbjct: 710  HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769

Query: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058
              SEL  + + E                              L   G+P       E +T
Sbjct: 770  SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829

Query: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117
             F  +         +L P S  S   P  P+  P   L   A+ ++P + S +  L    
Sbjct: 830  EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881

Query: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162
              SPS      +P P     + P+          ++   GSG LE
Sbjct: 882  PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%)

Query: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557
            S RSS+ D+A  LPN   D+L +TT              PS+ S  +E   +       S
Sbjct: 839  SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886

Query: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617
               D G  P P+          +    +   + S+   G L      + + +AS C    
Sbjct: 887  GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941

Query: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677
            +      EG Q +P   DP   K    +  E  P  L+ KV+ LE +LR+LQ DL+KEK 
Sbjct: 942  ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997

Query: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707
            D+A L+ EV+ LR +N RLQ ES++A  +L
Sbjct: 998  DRAALEEEVRSLRHNNRRLQAESESAATRL 1027


>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
            sapiens]
          Length = 1042

 Score =  617 bits (1590), Expect = e-176
 Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%)

Query: 327  RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385
            R FAHYDVQS+LF+     A R+  +G     ++G  A+++ Q                 
Sbjct: 114  RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152

Query: 386  DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445
                            S+DL+   P F  E GGEG+               G        
Sbjct: 153  --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184

Query: 446  LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505
            +     NA VS+LE P+        +   Y +EH DLGA YYRK+FYGKEHQN+FG+DE+
Sbjct: 185  VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237

Query: 506  LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565
            LGPVAVS+RRE+ E +    G+  +YRV  RT++L TLRG I EDA+P     G  RGL 
Sbjct: 238  LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291

Query: 566  LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625
             +++LE+V P+LS  CLR  S SPKV   LL LDEQ LSFQ K+GILYC+AGQ +EEEMY
Sbjct: 292  PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351

Query: 626  NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685
            NN+ AGPAF +FL LLG  VRLKGF  YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+
Sbjct: 352  NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411

Query: 686  LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745
            LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT + 
Sbjct: 412  LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471

Query: 746  CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804
             Y V VSR++D P FGP +P  G  F  +A FR FLLAK +N E AA  + +F AMATRT
Sbjct: 472  TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531

Query: 805  RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863
            RQ+YL+DLA N VTT ++D++ +F   +LG ++  +  PR   A L + G+++W V A  
Sbjct: 532  RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589

Query: 864  FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912
              + A           ++ CLLGIS E ++L+      VVFNC+CRDV+ WT     + +
Sbjct: 590  GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649

Query: 913  FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972
            ++ RGE + L    +  + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V 
Sbjct: 650  YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709

Query: 973  DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032
             VE F FA  AGLR G+RL+ +C   + +L  E    LLR++  V V ++ P + G PRR
Sbjct: 710  HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769

Query: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058
              SEL  + + E                              L   G+P       E +T
Sbjct: 770  SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829

Query: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117
             F  +         +L P S  S   P  P+  P   L   A+ ++P + S +  L    
Sbjct: 830  EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881

Query: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162
              SPS      +P P     + P+          ++   GSG LE
Sbjct: 882  PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%)

Query: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557
            S RSS+ D+A  LPN   D+L +TT              PS+ S  +E   +       S
Sbjct: 839  SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886

Query: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617
               D G  P P+          +    +   + S+   G L      + + +AS C    
Sbjct: 887  GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941

Query: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677
            +      EG Q +P   DP   K    +  E  P  L+ KV+ LE +LR+LQ DL+KEK 
Sbjct: 942  ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997

Query: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707
            D+A L+ EV+ LR +N RLQ ES++A  +L
Sbjct: 998  DRAALEEEVRSLRHNNRRLQAESESAATRL 1027


>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
           [Homo sapiens]
          Length = 715

 Score =  230 bits (586), Expect = 1e-59
 Identities = 135/333 (40%), Positives = 184/333 (55%), Gaps = 32/333 (9%)

Query: 487 YRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTS-----ELT 541
           YR+ F GK+H N++    +LG + +S++ E      E EG ++  RV  R+      E  
Sbjct: 142 YRRHFLGKDHLNFYCTGSSLGNLILSVKCE------EAEGIEY-LRVILRSKLKTVHERI 194

Query: 542 TLRGAILEDAIPSTARH--GTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLD 599
            L G     ++P  A+     A GL    VL                  PK S+ ++  D
Sbjct: 195 PLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLY-----------------PKASQMIVSYD 237

Query: 600 EQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDN 659
           E  ++   K G++Y KA Q+ EEE++ N    PAF+EFLDLLG  + L+ F  +R  LD 
Sbjct: 238 EHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDV 297

Query: 660 KTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPF 719
               TG  S+YTT++D E+MFHVST LP+   + QQL RKRHIGNDIV I+FQE    PF
Sbjct: 298 THGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENT-PF 356

Query: 720 TPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDF 779
            P  I S+F H +++V+V  P TE   Y V V+  +DVP FGPP+P    F K   FR+F
Sbjct: 357 VPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREF 416

Query: 780 LLAKVINAENAAHKSEKFRAMATRTRQEYLKDL 812
           LL K+ NAENA  KS+KF  +  RTR   L +L
Sbjct: 417 LLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 449


>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
           [Homo sapiens]
          Length = 730

 Score =  230 bits (586), Expect = 1e-59
 Identities = 135/333 (40%), Positives = 184/333 (55%), Gaps = 32/333 (9%)

Query: 487 YRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTS-----ELT 541
           YR+ F GK+H N++    +LG + +S++ E      E EG ++  RV  R+      E  
Sbjct: 157 YRRHFLGKDHLNFYCTGSSLGNLILSVKCE------EAEGIEY-LRVILRSKLKTVHERI 209

Query: 542 TLRGAILEDAIPSTARH--GTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLD 599
            L G     ++P  A+     A GL    VL                  PK S+ ++  D
Sbjct: 210 PLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLY-----------------PKASQMIVSYD 252

Query: 600 EQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDN 659
           E  ++   K G++Y KA Q+ EEE++ N    PAF+EFLDLLG  + L+ F  +R  LD 
Sbjct: 253 EHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDV 312

Query: 660 KTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPF 719
               TG  S+YTT++D E+MFHVST LP+   + QQL RKRHIGNDIV I+FQE    PF
Sbjct: 313 THGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENT-PF 371

Query: 720 TPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDF 779
            P  I S+F H +++V+V  P TE   Y V V+  +DVP FGPP+P    F K   FR+F
Sbjct: 372 VPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREF 431

Query: 780 LLAKVINAENAAHKSEKFRAMATRTRQEYLKDL 812
           LL K+ NAENA  KS+KF  +  RTR   L +L
Sbjct: 432 LLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 464


>gi|224809582 RAP1 GTPase activating protein isoform c [Homo
           sapiens]
          Length = 663

 Score =  221 bits (563), Expect = 5e-57
 Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%)

Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543
           A  YRK F GKEH NY+ +D  LG +  S++ + +       G Q + R+  RT   T  
Sbjct: 87  ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 137

Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602
                 D IP +        + + K V E V  +     L      PK S  ++  DE  
Sbjct: 138 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 188

Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662
           +S   K G++Y K GQ++EEE+++     PAF EFL+ LGQ+V+L+ F  +R  LD    
Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248

Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722
            TGT S+Y  +++ E+MFHVST LPY   + QQL RKRHIGNDIV +VFQ+    PF P 
Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 307

Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782
            I S+F H +V+V+      +   Y V V+   DVP FGPP+P    F K   F++FLL 
Sbjct: 308 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 367

Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814
           K+INAE A +K+EKF  +  RTR   L+ L E
Sbjct: 368 KLINAEYACYKAEKFAKLEERTRAALLETLYE 399


>gi|224809578 RAP1 GTPase activating protein isoform a [Homo
           sapiens]
          Length = 727

 Score =  221 bits (563), Expect = 5e-57
 Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%)

Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543
           A  YRK F GKEH NY+ +D  LG +  S++ + +       G Q + R+  RT   T  
Sbjct: 151 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 201

Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602
                 D IP +        + + K V E V  +     L      PK S  ++  DE  
Sbjct: 202 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 252

Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662
           +S   K G++Y K GQ++EEE+++     PAF EFL+ LGQ+V+L+ F  +R  LD    
Sbjct: 253 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 312

Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722
            TGT S+Y  +++ E+MFHVST LPY   + QQL RKRHIGNDIV +VFQ+    PF P 
Sbjct: 313 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 371

Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782
            I S+F H +V+V+      +   Y V V+   DVP FGPP+P    F K   F++FLL 
Sbjct: 372 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 431

Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814
           K+INAE A +K+EKF  +  RTR   L+ L E
Sbjct: 432 KLINAEYACYKAEKFAKLEERTRAALLETLYE 463


>gi|224809573 RAP1 GTPase activating protein isoform b [Homo
           sapiens]
          Length = 681

 Score =  221 bits (563), Expect = 5e-57
 Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%)

Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543
           A  YRK F GKEH NY+ +D  LG +  S++ + +       G Q + R+  RT   T  
Sbjct: 87  ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 137

Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602
                 D IP +        + + K V E V  +     L      PK S  ++  DE  
Sbjct: 138 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 188

Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662
           +S   K G++Y K GQ++EEE+++     PAF EFL+ LGQ+V+L+ F  +R  LD    
Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248

Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722
            TGT S+Y  +++ E+MFHVST LPY   + QQL RKRHIGNDIV +VFQ+    PF P 
Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 307

Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782
            I S+F H +V+V+      +   Y V V+   DVP FGPP+P    F K   F++FLL 
Sbjct: 308 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 367

Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814
           K+INAE A +K+EKF  +  RTR   L+ L E
Sbjct: 368 KLINAEYACYKAEKFAKLEERTRAALLETLYE 399


>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
           sapiens]
          Length = 1013

 Score =  217 bits (552), Expect = 9e-56
 Identities = 136/376 (36%), Positives = 202/376 (53%), Gaps = 31/376 (8%)

Query: 477 IEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFR 536
           +E+ +    +Y K+F G+ HQNY G D    P  +S+              Q N RV   
Sbjct: 89  LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTL----------SDQNNQRVPQY 138

Query: 537 TSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLL 596
            + L    G   +  +P    +   + L +K +L  +  +   +  R+  + P++ + LL
Sbjct: 139 RAILWRKTGT-QKICLP----YSPTKTLSVKSILSAMNLDKFEKGPREIFH-PEIQKDLL 192

Query: 597 KLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQ 656
            L+EQ  S   K G+L+ K GQ T++EM++NE     F++FL+LLG  + LKG++ YR  
Sbjct: 193 VLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGG 252

Query: 657 LDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQ--EP 714
           LD K D+TG HS+YT Y+ +E+MFHVST+LPY   N+QQ+ RKRHIGNDIVTIVFQ  E 
Sbjct: 253 LDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEE 312

Query: 715 GALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSA 774
            +  F P  IRSHF H+F +V+ +    +N  Y + +   + VP FGPP+P    F    
Sbjct: 313 SSPAFKPSMIRSHFTHIFALVRYNQ---QNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQ 369

Query: 775 VFRDFLLAKVINAENAAHKSEKFRAMATRT--------RQEYLKDLAENFVTTATVDTSV 826
            FRDFLL K+IN E A  ++  F     RT         Q+ + DL +N +   +    +
Sbjct: 370 EFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVL 429

Query: 827 KFSFITLGAKKKEKVK 842
             S     A+KKE+ +
Sbjct: 430 PES--PKSARKKEEAR 443


>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
            [Homo sapiens]
          Length = 2083

 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 11/235 (4%)

Query: 590  KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
            K+  +L  LD +     HKI + Y   GQ  +  +  N     A+E+F+  LG  V L  
Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850

Query: 650  FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
               +   L  K  STG  + Y      E++FHVST +P   ++   L +K RH+GND V 
Sbjct: 1851 HCGFMGGL-QKNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907

Query: 709  IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
            IV+ E     +    I + F  V +++       +N  +S+ + +  +VP FGP     +
Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVIYP----MKNHMFSIQIMKKPEVPFFGPLFDGAI 1962

Query: 769  TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVD 823
               K  V    + A  INA  A              R  YL+ + ++ +   T +
Sbjct: 1963 VNGK--VLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015


>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
            [Homo sapiens]
          Length = 2036

 Score = 74.3 bits (181), Expect = 9e-13
 Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 11/235 (4%)

Query: 590  KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
            K+  +L  LD +     HKI + Y   GQ  +  +  N     A+E+F+  LG  V L  
Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850

Query: 650  FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
               +   L  K  STG  + Y      E++FHVST +P   ++   L +K RH+GND V 
Sbjct: 1851 HCGFMGGL-QKNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907

Query: 709  IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
            IV+ E     +    I + F  V +++       +N  +S+ + +  +VP FGP     +
Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVIYP----MKNHMFSIQIMKKPEVPFFGPLFDGAI 1962

Query: 769  TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVD 823
               K  V    + A  INA  A              R  YL+ + ++ +   T +
Sbjct: 1963 VNGK--VLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015


>gi|118600961 akt substrate AS250 [Homo sapiens]
          Length = 1873

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 62/227 (27%), Positives = 101/227 (44%), Gaps = 11/227 (4%)

Query: 590  KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
            K+  +L  LD +     HKI + Y   GQ  +  + +NE    A+E+F+  LG  V L  
Sbjct: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689

Query: 650  FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
               +   L  +  STG  + Y      E++FHVST +P   ++   L +K RH+GND V 
Sbjct: 1690 HCGFMGGL-QRNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746

Query: 709  IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
            IV+ E  +  +    I + F  V +I+       +N  + + +++  +VP FGP     +
Sbjct: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAI 1801

Query: 769  TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEN 815
               K  +    + A  INA  A              R  YL+ + +N
Sbjct: 1802 VSGK--LLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQN 1846


>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
          Length = 1740

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)

Query: 587  NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
            N  +  E+ ++L +Q  S+  HKI +LY   GQS  E  + +NE     + EFL  LG+ 
Sbjct: 1455 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1514

Query: 645  VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
            + LK     +  L    D  G    +T     ++M   FH++TL+P    ++ +  +KRH
Sbjct: 1515 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1573

Query: 702  IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
            +GND V+IV+ + G   F   +I+  F  V VIV
Sbjct: 1574 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1606


>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
          Length = 1807

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)

Query: 587  NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
            N  +  E+ ++L +Q  S+  HKI +LY   GQS  E  + +NE     + EFL  LG+ 
Sbjct: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581

Query: 645  VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
            + LK     +  L    D  G    +T     ++M   FH++TL+P    ++ +  +KRH
Sbjct: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640

Query: 702  IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
            +GND V+IV+ + G   F   +I+  F  V VIV
Sbjct: 1641 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1673


>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
          Length = 1784

 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)

Query: 587  NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
            N  +  E+ ++L +Q  S+  HKI +LY   GQS  E  + +NE     + EFL  LG+ 
Sbjct: 1499 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1558

Query: 645  VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
            + LK     +  L    D  G    +T     ++M   FH++TL+P    ++ +  +KRH
Sbjct: 1559 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1617

Query: 702  IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
            +GND V+IV+ + G   F   +I+  F  V VIV
Sbjct: 1618 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1650


>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
          Length = 1747

 Score = 48.9 bits (115), Expect = 4e-05
 Identities = 58/243 (23%), Positives = 89/243 (36%), Gaps = 69/243 (28%)

Query: 973  DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLR---TSVTVKVVII--QPHDD 1027
            DVE  G AW+AGLR G  L+E+  V V  + H+Q++ L+R     + +KVV +  +P +D
Sbjct: 630  DVE--GVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEED 687

Query: 1028 GSPRRGCSELCRIPMVEYKLDSEGTPCEYK------------------------------ 1057
            G+ RR      R P     L S+    E +                              
Sbjct: 688  GARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIA 747

Query: 1058 ------TPFRRNTTWHRVPTPALQPLSRASPIPGTPDRLP---------------CQQLL 1096
                     ++  T  R+    +  L     +PG P++LP                ++L 
Sbjct: 748  DADSRAATVKQRPTSRRITPAEISSLFERQGLPG-PEKLPGSLRKGIPRTKSVGEDEKLA 806

Query: 1097 QQAQAAIPRSTSFDRKLPDGTRSSPSNQSS----------SSDPGPGGSGPWRPQVGYDG 1146
               +   PRSTS    + +G    P  Q++           S P P  S P  P   YD 
Sbjct: 807  SLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDT 866

Query: 1147 CQS 1149
             +S
Sbjct: 867  VRS 869



 Score = 31.6 bits (70), Expect = 7.0
 Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 2/58 (3%)

Query: 1080 ASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLP-DGTRSSPSNQSSSSDPGPGGSG 1136
            ASP P     LP Q LLQ+ Q    R    D++    G  +  + QS  SDPGPG  G
Sbjct: 387  ASPGPSLRS-LPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISDPGPGPGG 443


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 48.5 bits (114), Expect = 6e-05
 Identities = 61/261 (23%), Positives = 92/261 (35%), Gaps = 16/261 (6%)

Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
            D + SS SN SS+S      S         D   S    +   S   +   + +  D+  
Sbjct: 778  DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837

Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
            +S   ++          GS  + + + D S     +  S   + S SS SS +  SSN+S
Sbjct: 838  SSDSSDSS-----DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892

Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294
             +SD  +    D  D      +     S+DS   +                S S   S +
Sbjct: 893  DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS-----------DNSNSSDSSNS 941

Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA 1354
               +D++D S   D      S +   S+ S  S +  S        S  S      S S+
Sbjct: 942  SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001

Query: 1355 HCSKSSGSLDSSKVYIVSHSS 1375
            + S SS S DSS     S SS
Sbjct: 1002 NSSDSSDSSDSSDSSNSSDSS 1022



 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 75/318 (23%), Positives = 114/318 (35%), Gaps = 28/318 (8%)

Query: 1105 RSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECD 1164
            +S S D    D + SS S+ SS SD     S         D   S        S   +  
Sbjct: 546  KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605

Query: 1165 GAREREDTMEASRHPETKWHGPPSKVLGS------------YKERALQKDGSCKDSPNKL 1212
             + +  D+ ++S   ++K     S+   S              + +   D S   + +  
Sbjct: 606  DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665

Query: 1213 SHIGDKSCSSHSSSNTLSSNTSSNSDDKHFG----SGDLMDPELLGLTYIKGASTDSGID 1268
            S   D S SS SSS++ SSN+S +SD         S D  D      +    +S  +  D
Sbjct: 666  SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725

Query: 1269 TAPCMPATILGPVHLA----------GSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHG 1318
            +     +      + +           S S   S +   +D++D S   D      S   
Sbjct: 726  SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785

Query: 1319 YASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHS--SG 1376
              S+ S+ S+   +  D S  S  S  S  S S S++ S SS S DSS     S S  S 
Sbjct: 786  NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS 845

Query: 1377 QQVPGSMSKPYHRQGAVN 1394
                GS S   +R  + N
Sbjct: 846  DSSDGSDSDSSNRSDSSN 863



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 65/263 (24%), Positives = 98/263 (37%), Gaps = 8/263 (3%)

Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
            D + SS S++SS+S      S         D   S    +   S     D +   + +  
Sbjct: 916  DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS----DSSNSSDSSDS 971

Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
             S       +   S       + +   D S     +  S   D S SS SS+++ SSN+S
Sbjct: 972  NSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSS 1031

Query: 1235 SNSDDKHFG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSR 1293
             +SD      S D  D      +     S+DS  D++    ++         S S   S 
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS-DSSDSSDSSDSSD-SSDSSESSDSSD 1089

Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSP 1352
            +   +D++D S   D      S     S+ S+ S+      D S+ S  S+ S  S  S 
Sbjct: 1090 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSE 1149

Query: 1353 SAHCSKSSGSLDSSKVYIVSHSS 1375
            S+  S SS S DSS     S SS
Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDSS 1172



 Score = 40.4 bits (93), Expect = 0.015
 Identities = 61/253 (24%), Positives = 93/253 (36%), Gaps = 26/253 (10%)

Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
            D + SS S+ SS S      S         D   S        S   +   + +  D+ E
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS--------SDSSDSSDSSDSSDSSE 1083

Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
            +S   ++  +   S       + +   D S     +  S+  D S SS SS ++ SSN+S
Sbjct: 1084 SSDSSDSS-NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142

Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294
             +SD     S D  D      +     S+DS   +                S S   S +
Sbjct: 1143 DSSDSSE--SSDSSDSSDSSDSSDSSDSSDSSDSS--------------DSSNSSDSSDS 1186

Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSPS 1353
               +D++D S   D      S     S+ S+ S+      D S+ +  S  S  S  S S
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246

Query: 1354 AHCSKSSGSLDSS 1366
            ++ S SS S DSS
Sbjct: 1247 SNSSDSSDSSDSS 1259



 Score = 38.5 bits (88), Expect = 0.057
 Identities = 59/261 (22%), Positives = 94/261 (36%), Gaps = 21/261 (8%)

Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
            D + SS S+ S SSD     S         D   S    +   S   +   + +  D+ +
Sbjct: 703  DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS--DSSNSSDSSDSSD 760

Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
            +S   ++      S             D S     N  S+  D S SS+SS    SSN+S
Sbjct: 761  SSNSSDSSDSSDSSD----------SSDSSNSSDSNDSSNSSDSSDSSNSSD---SSNSS 807

Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294
             +SD       D  +      +     S+DS   +     +        + S S   S +
Sbjct: 808  DSSDSSDSSDSDSSN------SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861

Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA 1354
               +D++D S   +      S     S+ S+ S+   +  D     S +S      S S+
Sbjct: 862  SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921

Query: 1355 HCSKSSGSLDSSKVYIVSHSS 1375
              S+SS S D+S     S+SS
Sbjct: 922  DSSESSNSSDNSNSSDSSNSS 942



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 61/282 (21%), Positives = 99/282 (35%), Gaps = 49/282 (17%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME- 1174
            G +S P N+   S+ G   +        +D          QG  P   D +   +D    
Sbjct: 427  GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSM------QGDDPNSSDESNGNDDANSE 480

Query: 1175 ----ASRHPETKWHGPPSKVLGSYKERALQKD-----------------GSCKDSPNKLS 1213
                +S   +  ++   SK  G+  +    +D                 G+  +  N  S
Sbjct: 481  SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS 540

Query: 1214 HIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCM 1273
              G     S  S ++ SSN+S +SD     S D              +S+DS  D++   
Sbjct: 541  DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD------------SNSSSDS--DSSDSD 586

Query: 1274 PATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSM 1333
             +          S S   S +   +D++D S   D  +        +S   + S+   S 
Sbjct: 587  SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD-------SSKSESDSSDSDSK 639

Query: 1334 GDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSS 1375
             D S+ +S  S  +   S S++ S SS S DSS     S SS
Sbjct: 640  SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 45/198 (22%), Positives = 81/198 (40%), Gaps = 38/198 (19%)

Query: 974  VEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLR---TSVTVKVVIIQPH---DD 1027
            V+  G AW+AGLR G  L+E+    V  + H Q+++++R    ++ VKVV++  H   D+
Sbjct: 705  VDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDE 764

Query: 1028 GSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTP 1087
               ++   +  R+P     L S+    E +                ++   + +P+P   
Sbjct: 765  AVHKKAPQQAKRLPPPTISLRSKSMTSELE---------------EMEYEQQPAPVPSME 809

Query: 1088 DRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGG---SGPWRPQVGY 1144
             +    Q+                KL +   ++    S+S  PGPGG    G  RP+ G+
Sbjct: 810  KKRTVYQMAL-------------NKLDEILAAAQQTISASESPGPGGLASLGKHRPK-GF 855

Query: 1145 DGCQSPLLLEHQGSGPLE 1162
               +S     H+     E
Sbjct: 856  FATESSFDPHHRAQPSYE 873


>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
          Length = 1497

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 65/252 (25%), Positives = 97/252 (38%), Gaps = 34/252 (13%)

Query: 1310 PAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSPSAHCSKSSGSLDSSKV 1368
            P K  + +GYA T S G    GS  +   ++  SSG  +S GS   H S SS        
Sbjct: 31   PPKGGTSNGYAKTASLGG---GSRLEKQSLTHGSSGYINSTGSTRGHASTSS-------- 79

Query: 1369 YIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMS 1428
            Y  +HS    +P S    + R+  V ++      S G+  PE P          E    S
Sbjct: 80   YRRAHSPASTLPNSPGSTFERKTHVTRHAYE-GSSSGNSSPEYPR--------KEFASSS 130

Query: 1429 TATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLS 1488
            T  + QT   +     Q       + +  L D   + +G R  S    +SP R+   TL 
Sbjct: 131  TRGRSQTRESEIRVRLQSASPSTRWTE--LDDVKRLLKGSRSAS----VSPTRNSSNTLP 184

Query: 1489 -------DESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGS 1541
                   +  I +    S  G+  +++LD  LP+ +  ST P   S      +      S
Sbjct: 185  IPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTTQSSS 244

Query: 1542 LRNEFWFSDGSL 1553
            L N   +S GS+
Sbjct: 245  LLNTNAYSAGSV 256


>gi|148727255 microtubule associated serine/threonine kinase family
            member 4 isoform a [Homo sapiens]
          Length = 2434

 Score = 43.1 bits (100), Expect = 0.002
 Identities = 53/186 (28%), Positives = 78/186 (41%), Gaps = 25/186 (13%)

Query: 970  IVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGS 1029
            IV +VE    A +AGL+ G  +  I    V  L H ++I+LL  S     +   P ++ S
Sbjct: 984  IVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTS 1043

Query: 1030 ----PRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPAL----------Q 1075
                P R  S   R+     K   + +    ++ F++     + P+P L          +
Sbjct: 1044 IKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLA---KQPSPLLHTSRSFSCLNR 1100

Query: 1076 PLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDP-GPGG 1134
             LS    +PG+    P   L  ++     RST      P GT SS S+  SSS P  P G
Sbjct: 1101 SLSSGESLPGS----PTHSLSPRSPTPSYRSTP---DFPSGTNSSQSSSPSSSAPNSPAG 1153

Query: 1135 SGPWRP 1140
            SG  RP
Sbjct: 1154 SGHIRP 1159



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 24/97 (24%), Positives = 42/97 (43%), Gaps = 5/97 (5%)

Query: 1320 ASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA----HCSKSSGSLDSSKVYIVSHSS 1375
            AS  S+ +++  + G + E+ + S+  H    P+     H +KS  SL S +V  +   S
Sbjct: 2286 ASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSD-SLPSFRVSTLPLES 2344

Query: 1376 GQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEP 1412
                P +M    HR  A++      +     P P +P
Sbjct: 2345 HHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQP 2381


>gi|31742501 sorting nexin family member 27 [Homo sapiens]
          Length = 528

 Score = 42.7 bits (99), Expect = 0.003
 Identities = 22/59 (37%), Positives = 38/59 (64%), Gaps = 3/59 (5%)

Query: 971  VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRT---SVTVKVVIIQPHD 1026
            V+ V P G A +AG+R+G R++E+  V V   TH+Q++DL+R     + + V+ + PH+
Sbjct: 81   VSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHE 139


>gi|169173184 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1230

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 84/350 (24%), Positives = 118/350 (33%), Gaps = 45/350 (12%)

Query: 1113 LPDGTRSSPSNQSSSSDPGPGGSGP---WRPQVGYDGCQSPLLLEHQGSGPL---ECDGA 1166
            +P    +SPS   +S+    G + P   W       G  SP       S         GA
Sbjct: 126  IPSAFWASPSASGASTPSDSGWASPSASWASTSSDSGWASPSASWTSPSASCASSSASGA 185

Query: 1167 REREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCS--SHS 1224
                D+  AS  P   W  P +               S   SP+        S S  + S
Sbjct: 186  STPSDSGWAS--PSVFWVSPST---------------SWASSPSDFGWASTPSDSGWASS 228

Query: 1225 SSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLA 1284
            S++ +S + S  S     G        +   T     S+DSG  ++     +I       
Sbjct: 229  SASCISPSASGASTSSDSGWASPSASWVSTSTSRASTSSDSGWASSSASWDSITSDSGWV 288

Query: 1285 GSRSLIHSRAEQWADAADVSG---PDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISS 1341
               +   S +  WA A   SG   P    A   SV G+AS  ++G++A    G  S  +S
Sbjct: 289  CPSASWASSSASWASAPSDSGSSSPSVSRASTLSVSGWASFSASGASAPSDSGWTSHSAS 348

Query: 1342 HSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGW- 1400
              S +  SG  S   S +S S D          SG   P +        GA      GW 
Sbjct: 349  GVSTTSDSGWASPSASGASTSSD----------SGWASPSASWASPSASGASTPSDSGWA 398

Query: 1401 -KKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLS 1449
               + G+  P  P +  CPG         TA    TVVG   +   H +S
Sbjct: 399  SPSASGASMPSAPSL--CPG---SCFPQLTARTGFTVVGFPFSLLSHCIS 443


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score = 41.2 bits (95), Expect = 0.009
 Identities = 102/419 (24%), Positives = 141/419 (33%), Gaps = 72/419 (17%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYD-GCQSPLLLEHQGSGPLECDGAREREDTME 1174
            G   S S QSSS  P   GSG    +  Y+ G      L HQ S   +  G  +   +  
Sbjct: 546  GRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSG 605

Query: 1175 AS----RHPETK-------WHGPPSKVLGSY---------KERALQKDGSCKDSPNKLSH 1214
             S    +H  T         HG  S    S+           R  Q+      SP++  H
Sbjct: 606  HSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRH 665

Query: 1215 IGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMP 1274
              D   SS    +   S  SS++      SG     +  G  +  G+   SG        
Sbjct: 666  GSDFGHSSSYGQHGSGSGWSSSNGPHGSVSG-----QSSGFGHKSGSGQSSGYSQHGSGS 720

Query: 1275 ATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-M 1333
            +   G     GSRS   SR+EQ   ++ +S         Y  HG  S  S+G   +GS  
Sbjct: 721  SHSSG-YRKHGSRSGQSSRSEQHGSSSGLSSS-------YGQHGSGSHQSSGHGRQGSGS 772

Query: 1334 GDLSEISSHSSGSHHSGSPSAH-----CSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYH 1388
            G       H S S HS S   H     CS S G  +S      +   GQ   GS  + Y 
Sbjct: 773  GHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQ--ASGFGQHESGS-GQGYS 829

Query: 1389 RQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVL 1448
            + G+ +    G   S+G                S     S++ QH +  G + +  QH  
Sbjct: 830  QHGSAS----GHFSSQGRHG-------------STSGQSSSSGQHDSSSGQSSSYGQHES 872

Query: 1449 SKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRSS 1507
            +                 GR +       SP      + S +S    R GS  G S SS
Sbjct: 873  ASHH------------ASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSS 919



 Score = 41.2 bits (95), Expect = 0.009
 Identities = 71/284 (25%), Positives = 96/284 (33%), Gaps = 29/284 (10%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173
            G   S S+QSSS      GSG  P R + G     S    +H           R    + 
Sbjct: 1807 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 1866

Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228
            ++S    H  + W   G      GS    + ++ GS     ++    G  S SS S    
Sbjct: 1867 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQH 1926

Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
             S +  S    +H GSG    P      +  G+   S             GP       S
Sbjct: 1927 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSY-----------GPYGSGSGWS 1974

Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347
                  E  +  +   G  +  +   S +G   + S  S+  G  G  S  SS S G H 
Sbjct: 1975 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSS-SCGQHG 2033

Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390
              SG  S+H    SGS  SS         G+Q  GS   P H Q
Sbjct: 2034 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 2070



 Score = 38.9 bits (89), Expect = 0.044
 Identities = 70/284 (24%), Positives = 95/284 (33%), Gaps = 29/284 (10%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173
            G R S S+QSS       GSG  P R + G     S    +H           R    + 
Sbjct: 1337 GHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 1396

Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228
            ++S    H  + W   G      GS    + ++ GS     ++    G  S SS S    
Sbjct: 1397 QSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 1456

Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
             S +  S    +H GSG    P      +  G+   S              P       S
Sbjct: 1457 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSYS-----------PYGSGSGWS 1504

Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347
                  E  +  +   G  +  +   S +G   + S  S+  G  G  S  SS S G H 
Sbjct: 1505 SSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSS-SCGQHG 1563

Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390
              SG  S+H    SGS  SS         G+Q  GS   P H Q
Sbjct: 1564 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 1600



 Score = 38.9 bits (89), Expect = 0.044
 Identities = 70/284 (24%), Positives = 95/284 (33%), Gaps = 29/284 (10%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173
            G   S S+QSSS      GSG  P R + G     S    +H           R    + 
Sbjct: 2277 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336

Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228
            ++S    H  + W   G      GS    + ++ GS     ++    G  S SS S    
Sbjct: 2337 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 2396

Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
             S +  S    +H GSG    P      +  G+   S              P       S
Sbjct: 2397 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSYS-----------PYGSGSGWS 2444

Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347
                  E  +  +   G  +  +   S +G   + S  S+  G  G  S  SS S G H 
Sbjct: 2445 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSS-SCGQHG 2503

Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390
              SG  S+H    SGS  SS         G+Q  GS   P H Q
Sbjct: 2504 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 2540



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 77/311 (24%), Positives = 100/311 (32%), Gaps = 68/311 (21%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
            G   S S  SSS+ P    SG         G          GSG     G R+       
Sbjct: 676  GQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQ 735

Query: 1176 SRHPETKWHGPPSKVLGSYKERAL---QKDGSCKD------SPNKLSHIGDKSCSSHSSS 1226
            S   E   HG  S +  SY +      Q  G  +       SP+++ H    S S HSSS
Sbjct: 736  SSRSEQ--HGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRH---GSSSGHSSS 790

Query: 1227 NTL-SSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAG 1285
            +    S TS +S   H+ SG              G ++  G               H +G
Sbjct: 791  HGQHGSGTSCSSSCGHYESGS-------------GQASGFG--------------QHESG 823

Query: 1286 SRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSS 1344
            S        + ++     SG      +    HG  S  S+ S   + S G  S    H S
Sbjct: 824  S-------GQGYSQHGSASGHFSSQGR----HGSTSGQSSSSGQHDSSSGQSSSYGQHES 872

Query: 1345 GSHH----------SGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVN 1394
             SHH          SG    H  + SGS  S         SG+    S S   H  G+  
Sbjct: 873  ASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGR----SSSSGRHGSGSGQ 928

Query: 1395 KYVIGWKKSEG 1405
                G K S G
Sbjct: 929  SSGFGHKSSSG 939



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 29/77 (37%), Positives = 34/77 (44%), Gaps = 3/77 (3%)

Query: 1317 HGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSS- 1375
            HG  S  S+G   + S G  S  + H SGS HS S   H S+S  S  S +    S SS 
Sbjct: 922  HGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSS 981

Query: 1376 --GQQVPGSMSKPYHRQ 1390
              GQ   GS     H Q
Sbjct: 982  SYGQHGSGSRQSLGHGQ 998



 Score = 37.4 bits (85), Expect = 0.13
 Identities = 90/366 (24%), Positives = 120/366 (32%), Gaps = 61/366 (16%)

Query: 1116 GTRSSPSNQS--------SSSDPGPGGSGPWRP----QVGYDGCQSPLLLEHQ---GSGP 1160
            G+RS  S++S        SSS  G  GSG  +     Q G    QSP     +   GSG 
Sbjct: 961  GSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQ 1020

Query: 1161 LECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDK 1218
                G         +SR P     G  S  LG  + R+ Q  G  +   S    S  G  
Sbjct: 1021 SSSYGPYRSGSGWSSSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1079

Query: 1219 SCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATIL 1278
              +S  SS+      SS     H   G              G+S  SG            
Sbjct: 1080 GSTSGQSSSCGQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ-- 1124

Query: 1279 GPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLS 1337
             P H  G R     ++  +      SG      +    HG     S+G    E S G  S
Sbjct: 1125 SPGH--GQRGSGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSS 1178

Query: 1338 EISSHSSGSHHSGSPSAHCSKSS--------GSLDSSKVYIVSHSSGQQVPGSMSKPYHR 1389
              S H SGS HS     H S+S         GS   S  +   H SG +     S  + R
Sbjct: 1179 SYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR----QSSGHGR 1234

Query: 1390 QGAVNKYV---------IGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440
            QG+ + +          +G   S G         +      S     S   QH++  G +
Sbjct: 1235 QGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS 1294

Query: 1441 VAETQH 1446
             A +QH
Sbjct: 1295 SAYSQH 1300



 Score = 37.0 bits (84), Expect = 0.17
 Identities = 98/404 (24%), Positives = 132/404 (32%), Gaps = 80/404 (19%)

Query: 1116 GTRSSPSNQSSSSD---PGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDG--ARERE 1170
            G   S S QSSS+D    G G S  +       G  S       GSG     G       
Sbjct: 206  GQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSG 265

Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLS 1230
             +    RH  +          GS   ++L        S    SH+   S S HSSS+   
Sbjct: 266  QSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQH 325

Query: 1231 SNTSSNSDDK-HFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSL 1289
             + SS S  + H+ SG              G ++  G               H +GS   
Sbjct: 326  GSGSSYSYSRGHYESG-------------SGQTSGFG--------------QHESGS--- 355

Query: 1290 IHSRAEQWADAADVSGPDDEPAKLYSVHGYASTI---SAGSAAEGSMGDLSEISSHSSG- 1345
               ++  ++     SG      +  S  G AS+     + S    S G     S HSSG 
Sbjct: 356  --GQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGR 413

Query: 1346 ---SHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKK 1402
               S  SG    H  + SGS  S        SSGQ   G     + R  +   YV G   
Sbjct: 414  GQHSSGSGQSPGHGQRGSGSGQSP-------SSGQHGTG-----FGRSSSSGPYVSGSGY 461

Query: 1403 SEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSP 1462
            S G    E           S  +  S  TQH +  G +    QH              S 
Sbjct: 462  SSGFGHHE-----------SSSEHSSGYTQHGSGSGHSSGHGQHG-----------SRSG 499

Query: 1463 LVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRS 1506
                G R+ S  G+ S     + + S +S+  +R GS  G S S
Sbjct: 500  QSSRGERQGSSAGS-SSSYGQHGSGSRQSLGHSRHGSGSGQSPS 542



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 59/213 (27%), Positives = 74/213 (34%), Gaps = 23/213 (10%)

Query: 1314 YSVHGYASTISAGSAAEGSMGDLSEI---------SSHSSGSHHSGSPSA--HCSKSSGS 1362
            YS HG  S  S+G    GS    S           SS S G H SGS  +  H  + SGS
Sbjct: 244  YSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGS 303

Query: 1363 LDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYS 1422
              S     V H SG     S S   H  G+   Y  G  +S         +     G  S
Sbjct: 304  RQSPS--HVRHGSGS--GHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSS 359

Query: 1423 EMDV-------MSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDS-PLVEEGRRKFSFY 1474
                        S+  QH +  G A +  QH  S          +S      GR + S  
Sbjct: 360  GYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSG 419

Query: 1475 GNLSPRRSLYRTLSDESICSNRRGSSFGSSRSS 1507
               SP      + S +S  S + G+ FG S SS
Sbjct: 420  SGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSS 452



 Score = 36.6 bits (83), Expect = 0.22
 Identities = 74/281 (26%), Positives = 99/281 (35%), Gaps = 29/281 (10%)

Query: 1122 SNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPET 1181
            S+  SSS  G  GSG  R  +G+    S       G  P    G  E      +S     
Sbjct: 509  SSAGSSSSYGQHGSGS-RQSLGHSRHGSG-----SGQSPSPSRGRHESGSRQSSS----- 557

Query: 1182 KWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKH 1241
              +GP     G    R   + GS   S   L H   +S  S       SS+  S++  +H
Sbjct: 558  --YGPHGYGSGRSSSRGPYESGSGHSSG--LGHQESRSGQSSGYGQHGSSSGHSSTHGQH 613

Query: 1242 FG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADA 1300
               SG        G T   G S+  G   +    ++  G       +S   SR    +D 
Sbjct: 614  GSTSGQSSSCGQHGAT--SGQSSSHGQHGSGSSQSSRYGQQGSGSGQS--PSRGRHGSDF 669

Query: 1301 ADVS-----GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAH 1355
               S     G     +     HG  S  S+G   +   G  S  S H SGS HS     H
Sbjct: 670  GHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKH 729

Query: 1356 CSKSSGSLDSSK---VYIVSHSSGQQVPGS-MSKPYHRQGA 1392
             S+S  S  S +      +S S GQ   GS  S  + RQG+
Sbjct: 730  GSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGS 770



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 66/279 (23%), Positives = 90/279 (32%), Gaps = 31/279 (11%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
            G R S S QS S      GSG    +    G   P L E  G G  E    +    +   
Sbjct: 2069 GQRGSGSRQSPSYGRHGSGSG----RSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHG 2124

Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235
            S    +  +G      G       ++ GS   S ++    G  S  S       S +  S
Sbjct: 2125 SGSGHSSGYGQHGSRSGQSSRG--ERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHS 2182

Query: 1236 NSDDKH-FGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGP------------VH 1282
             S  +H  GSG        G     G S+  G   +    +++ G              H
Sbjct: 2183 PSRGRHGSGSGHSSSHGQHGSG--SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQH 2240

Query: 1283 LAGSRSLI----HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDLS 1337
             +GS        H      +   D  G     +  +  HG  S+ S+    +GS  G   
Sbjct: 2241 GSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSP 2300

Query: 1338 EISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSG 1376
                H SGS HS S   H S S  S  S +     H SG
Sbjct: 2301 SRGRHGSGSGHSSSYGQHGSGSGWSSSSGR-----HGSG 2334



 Score = 35.8 bits (81), Expect = 0.37
 Identities = 72/302 (23%), Positives = 95/302 (31%), Gaps = 26/302 (8%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
            G+  SPS        G G S  + P     G  S       GSG     G RE      +
Sbjct: 2412 GSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSS 2471

Query: 1176 --SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSS-NTLSSN 1232
               +H  +  H       GS   ++         S    SH    S SS SS      S 
Sbjct: 2472 GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSG 2531

Query: 1233 TSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLI-- 1290
            +  +      GSG    P         G S+ SG   +    ++  G    +  +S    
Sbjct: 2532 SGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYS 2591

Query: 1291 --------------HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGD 1335
                          H      +   +  G     +  Y  HG  S  S+G   +GS  G 
Sbjct: 2592 QHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQ 2651

Query: 1336 LSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVY--IVSHSS--GQQVPGS-MSKPYHRQ 1390
                  H SG  HS S   H S  SG   S   Y   + HSS  GQ   GS  S  Y + 
Sbjct: 2652 SPSRGRHGSGLGHSSSHGQHGS-GSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710

Query: 1391 GA 1392
            G+
Sbjct: 2711 GS 2712



 Score = 35.0 bits (79), Expect = 0.63
 Identities = 77/285 (27%), Positives = 95/285 (33%), Gaps = 36/285 (12%)

Query: 1122 SNQSSSSDPGPGGSGPWRP----QVGYDGCQSPLLLEHQ---GSGPLECDGAREREDTME 1174
            S+  SSS  G  GSG  +     Q G    QSP     +   GSG     G         
Sbjct: 1915 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWS 1974

Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNTLSSN 1232
            +SR P     G  S  LG  + R+ Q  G  +   S    S  G    +S  SS+     
Sbjct: 1975 SSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHG 2033

Query: 1233 TSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHS 1292
             SS     H   G              G+S  SG             P H  G R     
Sbjct: 2034 ASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRGSGSR 2076

Query: 1293 RAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSHHSGS 1351
            ++  +      SG      +    HG     S+G    E S G  S  S H SGS HS  
Sbjct: 2077 QSPSYGRHGSGSGRSSSSGQ----HGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2132

Query: 1352 PSAHCSKSSGSLDSSKVYIVSHSS---GQQVPGSMSKPYH-RQGA 1392
               H S+S  S    +    S SS   GQ   GS     H RQG+
Sbjct: 2133 YGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGS 2177



 Score = 35.0 bits (79), Expect = 0.63
 Identities = 86/356 (24%), Positives = 112/356 (31%), Gaps = 67/356 (18%)

Query: 1111 RKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERE 1170
            + L  G   S S QS S   G  GSG      G     SP      GSG           
Sbjct: 2402 QSLGHGQHGSGSGQSPSPSRGRHGSGS-----GQSSSYSPY-----GSG----------- 2440

Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNT 1228
                +SR P     G  S  LG  + R+ Q  G  +   S    S  G    +S  SS+ 
Sbjct: 2441 SGWSSSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 2499

Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
                 SS     H   G              G+S  SG             P H  G R 
Sbjct: 2500 GQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRG 2542

Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSH 1347
                ++  +      SG      +    HG     S+G    E S G  S  S H SGS 
Sbjct: 2543 SGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 2598

Query: 1348 HSGSPSAHCSKSS--------GSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYV-- 1397
            HS     H S+S         GS   S  +   H SG +     S  + RQG+ +     
Sbjct: 2599 HSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR----QSSGHGRQGSGSGQSPS 2654

Query: 1398 -------IGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQH 1446
                   +G   S G         +      S +   S   QH++  G + A +QH
Sbjct: 2655 RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710



 Score = 34.7 bits (78), Expect = 0.82
 Identities = 74/300 (24%), Positives = 93/300 (31%), Gaps = 32/300 (10%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVG-YDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
            G   S S QSSS  P   GSG W    G Y+   S       G G  E    +       
Sbjct: 1482 GRHGSGSGQSSSYSPYGSGSG-WSSSRGPYESGSS----HSSGLGHRESRSGQSSGYGQH 1536

Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSS-NTLSSNT 1233
             S    +  HG      G           S + S    SH    S SS SS      S +
Sbjct: 1537 GSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSS----SHGQHGSGSSQSSGYGRQGSGS 1592

Query: 1234 SSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLI--- 1290
              +      GSG    P         G S+ SG   +    ++  G    +  +S     
Sbjct: 1593 GQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQ 1652

Query: 1291 -------------HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDL 1336
                         H      +   +  G     +  Y  HG  S  S+G   +GS  G  
Sbjct: 1653 HGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQS 1712

Query: 1337 SEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVS-HSS--GQQVPGS-MSKPYHRQGA 1392
                 H SG  HS S   H S S  S         S HSS  GQ   GS  S  Y + G+
Sbjct: 1713 PSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS 1772



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 77/289 (26%), Positives = 92/289 (31%), Gaps = 50/289 (17%)

Query: 1111 RKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERE 1170
            + L  G   S S QS S   G  GSG      G     SP      GSG     G  E  
Sbjct: 1462 QSLGHGQHGSGSGQSPSPSRGRHGSGS-----GQSSSYSPY---GSGSGWSSSRGPYE-- 1511

Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNT 1228
                 S H         S  LG  + R+ Q  G  +   S    S  G    +S  SS+ 
Sbjct: 1512 ---SGSSH---------SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 1559

Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
                 SS     H   G              G+S  SG             P H  G R 
Sbjct: 1560 GQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRG 1602

Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSH 1347
                ++  +      SG      +    HG     S+G    E S G  S  S H SGS 
Sbjct: 1603 SGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 1658

Query: 1348 HSGSPSAHCSKSSGSLDSSKVYIVSHSS---GQQVPGSMSKPYH-RQGA 1392
            HS     H S+S  S    +    S SS   GQ   GS     H RQG+
Sbjct: 1659 HSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGS 1707



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 67/275 (24%), Positives = 92/275 (33%), Gaps = 27/275 (9%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERED---- 1171
            G+R SPS+    S  G   S     Q G  G        H  SG  +  G  + E     
Sbjct: 302  GSRQSPSHVRHGSGSGHSSS---HGQHG-SGSSYSYSRGHYESGSGQTSGFGQHESGSGQ 357

Query: 1172 TMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSS 1231
            +   S+H     H       GS   +A         S    S+   +S S HSS     S
Sbjct: 358  SSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHS 417

Query: 1232 NTSSNSD---DKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
            + S  S     +  GSG        G  +  G S+ SG          + G  + +G   
Sbjct: 418  SGSGQSPGHGQRGSGSGQSPSSGQHGTGF--GRSSSSG--------PYVSGSGYSSGFGH 467

Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSM-GDLSEISSHSSGSH 1347
              H  + + +      G     +  +  HG  S  S+    +GS  G  S    H SGS 
Sbjct: 468  --HESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSR 525

Query: 1348 HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGS 1382
             S   S H S S  S   S+     H SG +   S
Sbjct: 526  QSLGHSRHGSGSGQSPSPSR---GRHESGSRQSSS 557



 Score = 32.7 bits (73), Expect = 3.1
 Identities = 63/264 (23%), Positives = 85/264 (32%), Gaps = 40/264 (15%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
            G   S S QSSS      GSG      GY         +H         G R    +  +
Sbjct: 1638 GHHESSSGQSSSYSQHGSGSGH---SSGYG--------QHGSRSGQSSRGERHGSSSRSS 1686

Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSH-IGDKSCSSHSSSNTLSSNTS 1234
            SR+ +   HG  S+    +     Q  GS + SP++  H  G    SSH    + S  +S
Sbjct: 1687 SRYGQ---HGSGSRQSSGHGR---QGSGSGQ-SPSRGRHGSGLGHSSSHGQHGSGSGRSS 1739

Query: 1235 SNSD-DKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSR 1293
            S    +   G   +      G  +    S                G  H        H  
Sbjct: 1740 SRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS------------GSGHFCSQGQ--HGS 1785

Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDLSEISSHSSGSHHSGSP 1352
                +   D  G     +  +  HG  S+ S+    +GS  G       H SGS HS S 
Sbjct: 1786 TSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSY 1845

Query: 1353 SAHCSKSSGSLDSSKVYIVSHSSG 1376
              H S S  S  S +     H SG
Sbjct: 1846 GQHGSGSGWSSSSGR-----HGSG 1864



 Score = 32.0 bits (71), Expect = 5.3
 Identities = 44/162 (27%), Positives = 54/162 (33%), Gaps = 21/162 (12%)

Query: 1291 HSRAEQWADAADVS-GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS 1349
            H  +  W  +     G     +  Y  HG  S    G ++ G     S  SS S G H S
Sbjct: 1403 HHESSSWQSSGCTQHGSGSGHSSSYEQHGSRS----GQSSRGERHGSSSGSSSSYGQHGS 1458

Query: 1350 GSPSA--HCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSP 1407
            GS  +  H    SGS  S       H SG     S S PY           GW  S G  
Sbjct: 1459 GSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYS-PYGSGS-------GWSSSRG-- 1508

Query: 1408 PPEEPEVTECPGM---YSEMDVMSTATQHQTVVGDAVAETQH 1446
             P E   +   G+    S     S   QH +  G +    QH
Sbjct: 1509 -PYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1549



 Score = 32.0 bits (71), Expect = 5.3
 Identities = 78/305 (25%), Positives = 98/305 (32%), Gaps = 31/305 (10%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEH-QGSGPLECDGAREREDT 1172
            G   S S QSS       GSG  P R + G     S    +H  GSG     G  E    
Sbjct: 2160 GQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSG 2219

Query: 1173 MEA--SRHPETKWHGPPSKVLGSYKERALQKD--GSCKDSPNKLSHIGDKS--CSSHSSS 1226
              +   +H     H       GS       +   GS     +     G  +   SSH   
Sbjct: 2220 HSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQH 2279

Query: 1227 NTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGS 1286
             + SS +SS       GSG    P         G S+  G   +    ++  G  H +GS
Sbjct: 2280 GSGSSQSSSYGQQ---GSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGR-HGSGS 2335

Query: 1287 ---RSLIHSRAEQWADAADVS-GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSH 1342
                   H  +  W  +     G     +  Y  HG  S    G ++ G     S  SS 
Sbjct: 2336 GQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRS----GQSSRGERHGSSSGSSS 2391

Query: 1343 SSGSHHSGSPSA--HCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGW 1400
            S G H SGS  +  H    SGS  S       H SG     S S PY           GW
Sbjct: 2392 SYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYS-PYGSGS-------GW 2443

Query: 1401 KKSEG 1405
              S G
Sbjct: 2444 SSSRG 2448



 Score = 31.6 bits (70), Expect = 7.0
 Identities = 69/305 (22%), Positives = 89/305 (29%), Gaps = 57/305 (18%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEH------------QGSGPL 1161
            G   S S+QSS       GSG  P   Q G    QSP    H             GSG  
Sbjct: 1103 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLG 1162

Query: 1162 ECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCS 1221
            E  G    E +  + +      HG  S     Y +   +   S +       H      S
Sbjct: 1163 ESSGFGHHESS--SGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE----RHGSSSGSS 1216

Query: 1222 SHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPV 1281
            SH   +   S  SS    +  GSG        G     G S+  G   +    ++  GP 
Sbjct: 1217 SHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGL--GHSSSHGQHGSGSGRSSSRGPY 1274

Query: 1282 HLAGSRSLI-----------------------------HSRAEQWADAADVSGPDDEPAK 1312
                  S +                             H      +   D  G     + 
Sbjct: 1275 ESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSS 1334

Query: 1313 LYSVHGYASTISAGSAAEGS-MGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIV 1371
             Y   G  S+ S+G    G+  G       H SGS HS S   H S S  S  S +    
Sbjct: 1335 SYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGR---- 1390

Query: 1372 SHSSG 1376
             H SG
Sbjct: 1391 -HGSG 1394



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 82/329 (24%), Positives = 106/329 (32%), Gaps = 75/329 (22%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
            G   S S  SS+      GSG +  Q            +H  +        +E   T ++
Sbjct: 1755 GQHESGSGHSSAYSQHGSGSGHFCSQG-----------QHGSTSGQSSTFDQEGSSTGQS 1803

Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235
            S H +   HG  S    SY +   Q  GS + SP++  H      SS    +   S  SS
Sbjct: 1804 SSHGQ---HGSGSSQSSSYGQ---QGSGSGQ-SPSRGRHGSGSGHSSSYGQHGSGSGWSS 1856

Query: 1236 NSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAE 1295
            +S     GSG     +  G  + + +S  S   T     +         GSRS   SR E
Sbjct: 1857 SSGRHGSGSG-----QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE 1911

Query: 1296 QWADAADVS---------------------GPDDEPAKLYSVHGYASTISA-------GS 1327
            Q   ++  S                     G    P+     HG  S  S+       GS
Sbjct: 1912 QHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGS 1971

Query: 1328 AAEGSMGDLSEISSHSSGSHH-------------SGSPSAHCS----KSSGSLDSSKVYI 1370
                S G     S HSSG  H              GS S H S      S S  SS    
Sbjct: 1972 GWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQ 2031

Query: 1371 VSHSSGQQVP-------GSMSKPYHRQGA 1392
               SSGQ           S S  Y RQG+
Sbjct: 2032 HGASSGQSSSHGQHGSGSSQSSGYGRQGS 2060



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 67/250 (26%), Positives = 89/250 (35%), Gaps = 41/250 (16%)

Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
            G   + S QSSS   G  GSG  +   GY           QGSG  +  G  +R      
Sbjct: 2500 GQHGASSGQSSSH--GQHGSGSSQSS-GYG---------RQGSGSGQSPGHGQRGSGSRQ 2547

Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235
            S  P    HG      GS +  +  + GS     +   H    S  S S S   S +  S
Sbjct: 2548 S--PSYGRHGS-----GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHS 2600

Query: 1236 NSDDKHFG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSR-SLIHSR 1293
            +   +H   SG     E  G +   G+S+  G               H +GSR S  H R
Sbjct: 2601 SGYGQHGSRSGQSSRGERHGSS--SGSSSHYG--------------QHGSGSRQSSGHGR 2644

Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS----MGDLSEISSHSSGSHHS 1349
                +  +   G         S HG   + S  S++ G     +G  S    H SGS HS
Sbjct: 2645 QGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHS 2704

Query: 1350 GSPSAHCSKS 1359
             + S H S S
Sbjct: 2705 SAYSQHGSGS 2714


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 40.8 bits (94), Expect = 0.011
 Identities = 77/327 (23%), Positives = 123/327 (37%), Gaps = 43/327 (13%)

Query: 971  VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSP 1030
            V +V+  G A +AGLR G RLV++   +V   T+ Q+I L++ S     + I P D+   
Sbjct: 6    VKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDIL 65

Query: 1031 RRGCSELCRIPMVE-YKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTPDR 1089
            +   S+   +   E Y  ++   P      + R T       P  +  +RA+ +P     
Sbjct: 66   QLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY-----APPARASTRATMVPEPTSA 120

Query: 1090 LPCQQLLQQAQAAIPRSTSF----DRKLPDGTRSSPSNQS---SSSDPGPGGSGPWRPQV 1142
            LP            PRS +       ++P   R+   N S   S   P PG      P +
Sbjct: 121  LPSD----------PRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAF----PHL 166

Query: 1143 GYDGCQSPLLLEHQGS----GPLECDGAREREDTMEASRHP-ETKWHGPPSKVLGSYKER 1197
              +  ++P      GS      LEC  A     + +  R   E +      +   + ++R
Sbjct: 167  SSEP-RTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDR 225

Query: 1198 ----ALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELL 1253
                A  +   C  S + LS +G +      S + LS  T S    +  G G L+ P   
Sbjct: 226  LEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRS---AEALGPGALVSPRFE 282

Query: 1254 GLTYIKGASTDSGIDTAPCMPATILGP 1280
               +   AS  S   T  C    + GP
Sbjct: 283  RCGW---ASQRSSARTPACPTRDLPGP 306


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 40.4 bits (93), Expect = 0.015
 Identities = 40/160 (25%), Positives = 60/160 (37%), Gaps = 14/160 (8%)

Query: 1082 PIPGTPD----RLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGP 1137
            P PG P       P     QQ  A      + +R+    + SS S+ SSSS      S  
Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556

Query: 1138 WRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKER 1197
                   +G           S P++ + A +R  +   +     +   PP       K R
Sbjct: 2557 GSSSSDSEG----------SSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRR 2606

Query: 1198 ALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNS 1237
            +     S   S +  S     S SS SSS++ SS++SS+S
Sbjct: 2607 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646



 Score = 37.0 bits (84), Expect = 0.17
 Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%)

Query: 1069 VPTPALQPLSRASPIPGTPDRLPC-----QQLLQQAQAAIPRSTSFDRKLPDGTRSSPSN 1123
            VP P +       P   T  + P      Q   ++  ++   S+S        + SS S+
Sbjct: 2496 VPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSS 2555

Query: 1124 QSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKW 1183
              SSS    G S P +P+V      SP         P   +  RE        R PE   
Sbjct: 2556 SGSSSSDSEGSSLPVQPEVALKRVPSPT--------PAPKEAVRE-------GRPPEPT- 2599

Query: 1184 HGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDK 1240
               P+K        +     S   S +  S     S SS SSS++ SS++SS S  K
Sbjct: 2600 ---PAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAK 2653



 Score = 36.2 bits (82), Expect = 0.28
 Identities = 76/323 (23%), Positives = 110/323 (34%), Gaps = 66/323 (20%)

Query: 1063 NTTWHRVPTPALQPLS-RASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSP 1121
            N T  RVP  A + +S R SP            LL +A++  P S     ++      SP
Sbjct: 2379 NLTSPRVPLSAYERVSGRTSP-----------PLLDRARSRTPPSAPSQSRMTSERAPSP 2427

Query: 1122 SNQS----SSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQG--SGPLECDGAREREDTMEA 1175
            S++     S S   P    P  P       QS  L+      +G            T  A
Sbjct: 2428 SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSA 2487

Query: 1176 SRH-----------PETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHS 1224
              H           P +    PP+   G+ +  AL      K+  +  S     S SS S
Sbjct: 2488 GDHNGMLSVPAPGVPHSDVGEPPAST-GAQQPSALAALQPAKERRSSSSSSSSSSSSSSS 2546

Query: 1225 SSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLA 1284
            SS++ SS++S +S     GS   + PE+                    +P+    P    
Sbjct: 2547 SSSSSSSSSSGSSSSDSEGSSLPVQPEV----------------ALKRVPSPTPAPKEA- 2589

Query: 1285 GSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSS 1344
                             +   P+  PAK        S+ S+ S++  S    S  SS SS
Sbjct: 2590 ---------------VREGRPPEPTPAK----RKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630

Query: 1345 GSHHSGSPSAHCSKSSGSLDSSK 1367
             S  S S S+  S SS S   +K
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAK 2653



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 35/138 (25%), Positives = 50/138 (36%), Gaps = 9/138 (6%)

Query: 1110 DRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPL----LLEHQGSGPLECDG 1165
            D+K    TR SPS + SS+ P P    P   +  + G   PL    L +   + P E   
Sbjct: 341  DKKEKSATRPSPSPERSSTGPEPPAPTPLLAE-RHGGSPQPLATTPLSQEPVNPPSEASP 399

Query: 1166 AREREDTMEASRHPE--TKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSH 1223
             R+R       + P+  +    PPS         A     S K +P   SH   +  SS 
Sbjct: 400  TRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSH--REISSSP 457

Query: 1224 SSSNTLSSNTSSNSDDKH 1241
            +S N        +    H
Sbjct: 458  TSKNRSHGRAKRDKSHSH 475


>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
            sapiens]
          Length = 358

 Score = 39.7 bits (91), Expect = 0.026
 Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 6/72 (8%)

Query: 962  GFHVNFEG-----IVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSV- 1015
            GFH++ E       +  VEP   A KAGL  G RLVE+    V   TH+Q++  +R ++ 
Sbjct: 25   GFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALN 84

Query: 1016 TVKVVIIQPHDD 1027
             V+++++ P  D
Sbjct: 85   AVRLLVVDPETD 96


>gi|8923040 CDKN2A interacting protein [Homo sapiens]
          Length = 580

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 65/242 (26%), Positives = 96/242 (39%), Gaps = 26/242 (10%)

Query: 1152 LLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSY--KERALQKDGSCKDSP 1209
            ++E + S  +E D A+    T  AS   E       S  +GS    E       S   S 
Sbjct: 145  VIEGKNSSAVEQDHAKTSAKTERASAQQENS-----STCIGSAIKSESGNSARSSGISSQ 199

Query: 1210 NKLSHIGDKSCSSHSSSNTLSSNTSSNS--------DDKHFGSGDLMDPELLGLTYIKGA 1261
            N  +  GD+S SS SSS+  S  T++ S         DKH GS   +      +      
Sbjct: 200  NSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKH-GSASFVSLLKSSVNSHMTQ 258

Query: 1262 STDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYAS 1321
            STDS   +     + + G      S S   S +E        SG  +    L S    + 
Sbjct: 259  STDSRQQSGSPKKSALEG-----SSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSE 313

Query: 1322 TISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPG 1381
            T S+G  ++ S  + S  SS +  S  SG+ S    KSS S ++S   +++  S  QV  
Sbjct: 314  TASSGLTSKTS-SEASVSSSVAKNSSSSGT-SLLTPKSSSSTNTS---LLTSKSTSQVAA 368

Query: 1382 SM 1383
            S+
Sbjct: 369  SL 370


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 38.9 bits (89), Expect = 0.044
 Identities = 58/199 (29%), Positives = 81/199 (40%), Gaps = 54/199 (27%)

Query: 968  EGI-VADVEPFGFAWKAG-LRQGSRLVEICKVAVATLTHEQMIDLLRT---SVTVKV--- 1019
            EGI ++ V P G A + G LR G RL+E+ + ++  LTH + + LLR+   ++TV V   
Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191

Query: 1020 --------------VIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTT 1065
                          VI  P   G   R   E   I  ++ +L  EG   E + P  +   
Sbjct: 1192 FEASTDAALEVSPGVIANPFAAGIGHRNSLE--SISSIDRELSPEGPGKEKELP-GQTLH 1248

Query: 1066 WHRVPTPA----LQPLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRS-- 1119
            W    T A    LQPL                +L  +A AA+P + S  R +P G     
Sbjct: 1249 WGPEATEAAGRGLQPL----------------KLDYRALAAVPSAGSVQR-VPSGAAGGK 1291

Query: 1120 ------SPSNQSSSSDPGP 1132
                  SPS Q   S P P
Sbjct: 1292 MAESPCSPSGQQPPSPPSP 1310



 Score = 37.7 bits (86), Expect = 0.097
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 18/105 (17%)

Query: 957  GLGQLGFHVNFEGI-VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSV 1015
            G G   +  + EGI ++ V   G A +AG+R G +L+E+  VA+    H + ++ LR + 
Sbjct: 745  GKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAG 804

Query: 1016 T-----------------VKVVIIQPHDDGSPRRGCSELCRIPMV 1043
            T                 V +  ++P DD SPR       R+P++
Sbjct: 805  TAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLL 849



 Score = 31.2 bits (69), Expect = 9.1
 Identities = 24/78 (30%), Positives = 40/78 (51%), Gaps = 6/78 (7%)

Query: 963  FHVNFEGI-VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMID-LLRTSVTVKVV 1020
            F V   G+ ++ V P G A ++GLR G R++ +    V   TH++ +  LLR  + + ++
Sbjct: 1029 FGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088

Query: 1021 IIQPHDDGSPRRGCSELC 1038
            +    D   P  G  ELC
Sbjct: 1089 V--RRDPAPP--GLRELC 1102


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,486,260
Number of Sequences: 37866
Number of extensions: 3506879
Number of successful extensions: 15550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 14879
Number of HSP's gapped (non-prelim): 688
length of query: 1722
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1606
effective length of database: 13,855,062
effective search space: 22251229572
effective search space used: 22251229572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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