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Search of human proteins with 112421013
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112421013 signal-induced proliferation-associated 1 like 2
[Homo sapiens]
(1722 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112421013 signal-induced proliferation-associated 1 like 2 [H... 3481 0.0
gi|7662126 signal-induced proliferation-associated 1 like 1 [Hom... 1571 0.0
gi|71143119 signal-induced proliferation-associated 1 like 3 [Ho... 1330 0.0
gi|206725526 signal-induced proliferation-associated protein 1 [... 617 e-176
gi|206725523 signal-induced proliferation-associated protein 1 [... 617 e-176
gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform ... 230 1e-59
gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform ... 230 1e-59
gi|224809582 RAP1 GTPase activating protein isoform c [Homo sapi... 221 5e-57
gi|224809578 RAP1 GTPase activating protein isoform a [Homo sapi... 221 5e-57
gi|224809573 RAP1 GTPase activating protein isoform b [Homo sapi... 221 5e-57
gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo sa... 217 9e-56
gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2... 74 9e-13
gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1... 74 9e-13
gi|118600961 akt substrate AS250 [Homo sapiens] 70 1e-11
gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens] 67 2e-10
gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens] 67 2e-10
gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens] 67 2e-10
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 49 4e-05
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 49 6e-05
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 46 4e-04
gi|119829187 alpha 1 type XVII collagen [Homo sapiens] 44 0.002
gi|148727255 microtubule associated serine/threonine kinase fami... 43 0.002
gi|31742501 sorting nexin family member 27 [Homo sapiens] 43 0.003
gi|169173184 PREDICTED: hypothetical protein [Homo sapiens] 42 0.007
gi|57864582 hornerin [Homo sapiens] 41 0.009
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 41 0.011
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 40 0.015
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 40 0.026
gi|8923040 CDKN2A interacting protein [Homo sapiens] 39 0.044
gi|45827729 scribble isoform b [Homo sapiens] 39 0.044
>gi|112421013 signal-induced proliferation-associated 1 like 2 [Homo
sapiens]
Length = 1722
Score = 3481 bits (9025), Expect = 0.0
Identities = 1722/1722 (100%), Positives = 1722/1722 (100%)
Query: 1 MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG 60
MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG
Sbjct: 1 MSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETG 60
Query: 61 GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD 120
GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD
Sbjct: 61 GGGPANGTPAVPKMGVRARVSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSD 120
Query: 121 QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV 180
QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV
Sbjct: 121 QSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAV 180
Query: 181 NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI 240
NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI
Sbjct: 181 NPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAI 240
Query: 241 SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS 300
SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS
Sbjct: 241 SPSLHAAAQISRGEFVRISGLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKS 300
Query: 301 EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG 360
EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG
Sbjct: 301 EHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTG 360
Query: 361 ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG 420
ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG
Sbjct: 361 ASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEG 420
Query: 421 DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI 480
DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI
Sbjct: 421 DRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHI 480
Query: 481 DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL 540
DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL
Sbjct: 481 DLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSEL 540
Query: 541 TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE 600
TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE
Sbjct: 541 TTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDE 600
Query: 601 QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK 660
QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK
Sbjct: 601 QGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNK 660
Query: 661 TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT 720
TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT
Sbjct: 661 TDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFT 720
Query: 721 PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL 780
PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL
Sbjct: 721 PKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFL 780
Query: 781 LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK 840
LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK
Sbjct: 781 LAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEK 840
Query: 841 VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV 900
VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV
Sbjct: 841 VKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDV 900
Query: 901 IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ 960
IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ
Sbjct: 901 IGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQ 960
Query: 961 LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV 1020
LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV
Sbjct: 961 LGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVV 1020
Query: 1021 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA 1080
IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA
Sbjct: 1021 IIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRA 1080
Query: 1081 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP 1140
SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP
Sbjct: 1081 SPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRP 1140
Query: 1141 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ 1200
QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ
Sbjct: 1141 QVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQ 1200
Query: 1201 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG 1260
KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG
Sbjct: 1201 KDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKG 1260
Query: 1261 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA 1320
ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA
Sbjct: 1261 ASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYA 1320
Query: 1321 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP 1380
STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP
Sbjct: 1321 STISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVP 1380
Query: 1381 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440
GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA
Sbjct: 1381 GSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440
Query: 1441 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS 1500
VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS
Sbjct: 1441 VAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSS 1500
Query: 1501 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA 1560
FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA
Sbjct: 1501 FGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKSKCA 1560
Query: 1561 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH 1620
DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH
Sbjct: 1561 DPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQH 1620
Query: 1621 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA 1680
GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA
Sbjct: 1621 GQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKA 1680
Query: 1681 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS 1722
VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS
Sbjct: 1681 VLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWFFTTIDKKS 1722
>gi|7662126 signal-induced proliferation-associated 1 like 1 [Homo
sapiens]
Length = 1804
Score = 1571 bits (4067), Expect = 0.0
Identities = 929/1874 (49%), Positives = 1185/1874 (63%), Gaps = 227/1874 (12%)
Query: 1 MSDPRQSQEEKH-KLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNET 59
M+ ++SQ E+ RAS D + +DD++ R+F++ NG++G + + +
Sbjct: 1 MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSV-MAPVGPPRS 59
Query: 60 GGGGPANGTPAVPKMGVRARVSEWPPKKDCSKELT--CKALWESRSQTSYESITSVLQNG 117
G TP VPKMGVRAR+++WPP+K+ KE + + + S S S +S + G
Sbjct: 60 EGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQG 119
Query: 118 QSDQSEGQQDEQLDL------------DFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVT 165
S L + +++++ + + + SP++ L IRQRSNSD+T
Sbjct: 120 SSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDIT 179
Query: 166 ISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAM 225
IS++D + + + TG +LHREYGSTSSID+QG SGE+FF +L+GY+ + D +
Sbjct: 180 ISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSD-RGP 238
Query: 226 VPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLDYVDSA------LLMGRDRDKPFK 279
P +F I+ G LD +D L + ++R+KP K
Sbjct: 239 TPTKLSDFL---------------ITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLK 283
Query: 280 RRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILF 339
RR KSE+ ++S+FRKLR K E +S+LE++R E +RPW C +CFAHYDVQSILF
Sbjct: 284 RRSKSETGDSSIFRKLRNAKGEE--LGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILF 341
Query: 340 NINEAMATRANVGKRKNITTGASAASQTQM---PTGQTGNCESPLGSKEDLNSKENLDAD 396
++NEA+ R NV KR+N TTGASAA+ + P + + SP+GS EDLNSK +L D
Sbjct: 342 DLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMD 401
Query: 397 EGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESSLSSHCTNAGVS 456
+GD KSN+LV+SCPYFRNE GGEG+R+I+LS++NS SFS ES SFES+LSSHCTNAGV+
Sbjct: 402 QGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVA 461
Query: 457 VLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRRE 516
VLEVP+EN +H ++VKRYI+EH+DLGAYYYRKFFY KEH NYFG DENLGPVAVSIRRE
Sbjct: 462 VLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRRE 521
Query: 517 KVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPE 576
K ++ KE GS +NYR+ FRTSEL TLRG++LEDAIPSTA+H TARGLPLKEVLE+V+PE
Sbjct: 522 KPDEMKEN-GSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPE 580
Query: 577 LSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEE 636
L++QCLR A N+PKV+EQL+KLDEQGL++Q K+GI+YCKAGQSTEEEMYNNE+AGPAFEE
Sbjct: 581 LNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEE 640
Query: 637 FLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQL 696
FL LLG+RVRLKGF KYRAQLD KTDSTGTHSLYTTYKDYE+MFHVST+LPY PNN+QQL
Sbjct: 641 FLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQL 700
Query: 697 LRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKD 756
LRKRHIGNDIVTIVFQEPGA PF+PK+IRSHFQHVFVIV+VHNPC+++VCYSV V+RS+D
Sbjct: 701 LRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRD 760
Query: 757 VPPFGPPIPKGVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENF 816
VP FGPPIPKGVTFPKS VFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAE
Sbjct: 761 VPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKN 820
Query: 817 VTTATVDTSVKFSFITLGAKKKEKVKPRKDAHLFSIGAIMWHVIARDFGQSADIECLLGI 876
VT +D S KF FI+L +KKKEK KP A L S+GAI+W V A D+ ++ +++CLLGI
Sbjct: 821 VTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGI 880
Query: 877 SNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKVFYERGECVLLSSVDNCAEDIREIV 936
SNEFI+LIE+++K+VVFNCSCRDVIGWTS S+K+FYERGECV + S N E+I+EIV
Sbjct: 881 SNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFIN-IEEIKEIV 939
Query: 937 QRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVADVEPFGFAWKAGLRQGSRLVEICK 996
+RL V++GCE+VEMTLRRNGLGQLGFHVN+EGIVADVEP+G+AW+AGLRQGSRLVEICK
Sbjct: 940 KRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICK 999
Query: 997 VAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEY 1056
VAVATL+HEQMIDLLRTSVTVKVVII PHDD +PRR CSE R+P++EYK+ +EG E+
Sbjct: 1000 VAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKM-NEGVSYEF 1058
Query: 1057 KTPFRRNTTWHR----------VPTPALQPL-SRASPIPGTPDRLPCQQLLQQAQAAIPR 1105
K PFR N W R VP+ P+ SR + G P + A IPR
Sbjct: 1059 KFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPP-----PERAANIPR 1113
Query: 1106 STSFD-----RKLPDGT----------------RSSPSNQSSSSDPGPGGSGPWRPQVGY 1144
S S D R+L G+ R+SPSN SSSSD G G G +R +
Sbjct: 1114 SISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVG-GTYRQKSMP 1172
Query: 1145 DGC----QSPLLLEHQ-------GSGPLECDGARERED------------------TMEA 1175
+G +SP ++ Q GSG R + +E
Sbjct: 1173 EGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQ 1232
Query: 1176 SRHPETKWHGPP-SKVLGSYKE----RALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLS 1230
+ E H P SKVL +++E R +++D SPNK H D SSHSSSNTLS
Sbjct: 1233 HEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGH-SDSHYSSHSSSNTLS 1291
Query: 1231 SNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVH-----LAG 1285
SN SS D+ + GD + EL Y++G S DSGIDT T GP H L
Sbjct: 1292 SNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDT------TSYGPSHGSTASLGA 1345
Query: 1286 SRSLIHSR------AEQWADAADVSGPDD--------------EPAKLYSVHGYASTISA 1325
+ S S A W +++V D E + +H + S
Sbjct: 1346 ATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGST 1405
Query: 1326 GSAAEGSMGDLSEISSHSS--GSHHSGSPSAHCSKSSGSLD-----SSKVYIVSHSSGQQ 1378
E S +++ +SH+S S HS SP S S + + S SS
Sbjct: 1406 PLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSS 1465
Query: 1379 VPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVG 1438
Y RQGA +KY+IGWKK EG+ + + M T +HQ+ G
Sbjct: 1466 SSSGPRSFYPRQGATSKYLIGWKKPEGT--------------INSVGFMDTRKRHQS-DG 1510
Query: 1439 DAVAETQHVLS----------------KEDFLKLMLPDSPLVEEGRRKFSFYGNLSP--- 1479
+ +A T+ S +ED KL+ +SP E ++ F F+ SP
Sbjct: 1511 NEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESP-TPESQKSFKFHALSSPQSP 1569
Query: 1480 -------RRSLYRTLSDESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPR 1532
RR+L+RTLSDESI +++R F +SR+S+LDQALPND+LFS+T P P
Sbjct: 1570 FPSTPTSRRALHRTLSDESIYNSQR-EHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPL 1628
Query: 1533 AHPAPSMG--SLRNEFWFSDGSLSD-----KSKCADPGLMPLPDTATGLDWTHLVDAARA 1585
P+ ++G SL EF SD SL+D + DPGLMPLPDTA LDW++LVDAA+A
Sbjct: 1629 RRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKA 1688
Query: 1586 FEGLDSDEELGLLCHHTSYLDQRVASFCTLTDMQHGQDLEGAQELPLCVDPGSGKEFMDT 1645
+E + ASF +D H + L A D + +
Sbjct: 1689 YE-------------------VQRASFFAASDENH-RPLSAASNSDQLEDQALAQMKPYS 1728
Query: 1646 TGERSPSPLTGKVNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATA 1705
+ + S L KV+QLE +L+ L+ DL+KEK+DKA LQAEVQHLR+DN+RLQEESQ A+
Sbjct: 1729 SSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASD 1788
Query: 1706 QLRKFTEWFFTTID 1719
+L+KFTEW F TID
Sbjct: 1789 KLKKFTEWVFNTID 1802
>gi|71143119 signal-induced proliferation-associated 1 like 3 [Homo
sapiens]
Length = 1781
Score = 1330 bits (3443), Expect = 0.0
Identities = 825/1797 (45%), Positives = 1059/1797 (58%), Gaps = 169/1797 (9%)
Query: 32 DYFARKFKAINGNMGPTTSLNASNSNETGGGG--PANGTPAVPKMGVRARVSEWPPKKDC 89
DY F A NG+M + + + T P+ TPA+PKMGVRARV++WPPK++
Sbjct: 33 DYAPLGFWAQNGSMSQPLGESPATATATATATTRPSPTTPAMPKMGVRARVADWPPKREA 92
Query: 90 SKELTCKALWESRSQTSYESITSVL---QNGQSDQSEGQQDEQLDLDFVEAKYT----IG 142
+E + + + T + + QNGQ S + + +
Sbjct: 93 LREHSNPSPSQDTDGTKATKMAHSMRSIQNGQPPTSTPASSGSKAFHRLSRRRSKDVEFQ 152
Query: 143 DIFVHSPQRGLHPIRQRSNSDVTISDIDAEDVLDQNAVNPNTGAALHREYGSTSSIDRQG 202
D + SP R P+R RS+S++T+S+ DAED + L REYGSTSSID QG
Sbjct: 153 DGWPRSPGRAFLPLRHRSSSEITLSECDAEDAGEPRGARHTGALPLFREYGSTSSIDVQG 212
Query: 203 LSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRISGLD 262
+ ++FF +L +R E D + E R DP P L ++G+ +G
Sbjct: 213 MPEQSFFDILNEFRSEQPDARGCQ--ALTELLRADPG--PHLMGGGGGAKGD--SHNGQP 266
Query: 263 YVDSALLMGRDRDKPFKRRLKS------ESVETSLFRKLRTVKSEHETFKFTSELEESRL 316
DS L + ++K R+ + ++V++S+FRKLR+ K E E + E +E R
Sbjct: 267 AKDSLLPLQPTKEKEKARKKPARGLGGGDTVDSSIFRKLRSSKPEGEAGRSPGEADEGRS 326
Query: 317 E-RGIRPWNCQRCFAHYDVQSILFNINEAMATRANVGKRKNITTGASAASQTQMPTGQTG 375
RPW CQ+ FAH+DVQS+LF++NEA A R +V +R+N TTGASAAS T
Sbjct: 327 PPEASRPWVCQKSFAHFDVQSMLFDLNEAAANRVSVSQRRNTTTGASAASAASAMASLTA 386
Query: 376 NCESPLG-------SKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSR 428
+ LG S EDLN KENL+ D GD SNDL+LSCP+FRNE GGE +R ++ SR
Sbjct: 387 SRAHSLGGLDPAFTSTEDLNCKENLEQDLGDDNSNDLLLSCPHFRNEIGGECERNVSFSR 446
Query: 429 ANSSSFSSGESCSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYR 488
A+ S SSGE E +LS++ TNA +SVLEVP+E Q + + ++Y IEH+DLGA YY+
Sbjct: 447 ASVGSPSSGEGHLAEPALSAYRTNASISVLEVPKEQQRT-QSRPRQYSIEHVDLGARYYQ 505
Query: 489 KFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAIL 548
+F GKEH NYFG+DE LGPVAVSI+REK+ED KE G Q+ YR+ FRT EL TLRG+IL
Sbjct: 506 DYFVGKEHANYFGVDEKLGPVAVSIKREKLEDHKE-HGPQYQYRIIFRTRELITLRGSIL 564
Query: 549 EDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHK 608
EDA P+ +HGT RGLPLK+ LEYVIPEL+I CLR A N+PKV+EQLLKLDEQGL +HK
Sbjct: 565 EDATPTATKHGTGRGLPLKDALEYVIPELNIHCLRLALNTPKVTEQLLKLDEQGLCRKHK 624
Query: 609 IGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHS 668
+GILYCKAGQS+EEEMYNNE AGPAFEEFL L+G++V LKGF+KY AQLD KTDSTGTHS
Sbjct: 625 VGILYCKAGQSSEEEMYNNEEAGPAFEEFLSLIGEKVCLKGFTKYAAQLDVKTDSTGTHS 684
Query: 669 LYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHF 728
LYT Y+DYE+MFHVSTLLPY PNNRQQLLRKRHIGNDIVTI+FQEPGALPFTPK+IRSHF
Sbjct: 685 LYTMYQDYEIMFHVSTLLPYTPNNRQQLLRKRHIGNDIVTIIFQEPGALPFTPKNIRSHF 744
Query: 729 QHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLAKVINAE 788
QHVF+IV+VHNPCT+NVCYS+ V+RSKD PPFGPPIP G TF KS VFRDFLLAKVINAE
Sbjct: 745 QHVFIIVRVHNPCTDNVCYSMAVTRSKDAPPFGPPIPSGTTFRKSDVFRDFLLAKVINAE 804
Query: 789 NAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPRKDAH 848
NAAHKS+KF MATRTRQEYLKDLAEN V+ +D++ KF+ I+L +KKKEK K R A
Sbjct: 805 NAAHKSDKFHTMATRTRQEYLKDLAENCVSNTPIDSTGKFNLISLTSKKKEKTKARAGAE 864
Query: 849 LFSIGAIMWHVIARDFGQSADIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLV 908
S GAI W V+A+D+ Q +I+C+LGISNEF++L++ +K VVFNC C DVIGWT
Sbjct: 865 QHSAGAIAWRVVAQDYAQGVEIDCILGISNEFVVLLDLRTKEVVFNCYCGDVIGWTPDSS 924
Query: 909 SIKVFYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFE 968
++K+FY RG+ + L + + EDIREIVQRL ++T G ETV+MTLRRNGLGQLGFHV ++
Sbjct: 925 TLKIFYGRGDHIFLQATEGSVEDIREIVQRLKVMTSGWETVDMTLRRNGLGQLGFHVKYD 984
Query: 969 GIVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDG 1028
G VA+VE +GFAW+AGLRQGSRLVEICKVAV TLTH+QMIDLLRTSVTVKVVII P +DG
Sbjct: 985 GTVAEVEDYGFAWQAGLRQGSRLVEICKVAVVTLTHDQMIDLLRTSVTVKVVIIPPFEDG 1044
Query: 1029 SPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWH---------------RVPTPA 1073
+PRRG E + E K + E + P+R N W PT
Sbjct: 1045 TPRRGWPETYDMNTSEPKTEQESITPGGRPPYRSNAPWQWSGPASHNSLPASKWATPTTP 1104
Query: 1074 LQPLSRASPIPGTP--DRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPG 1131
S + P+ TP Q L + + P T + R P Q S S
Sbjct: 1105 GHAQSLSRPLKQTPIVPFRESQPLHSKRPVSFP-ETPYTVSPAGADRVPPYRQPSGSFST 1163
Query: 1132 PGGSGPWRPQVG---YDGCQSPLL-----LEHQG--SGPLECDGAREREDTMEASRHPET 1181
PG + R + Y PLL H G SG G +E TME + PE
Sbjct: 1164 PGSATYVRYKPSPERYTAAPHPLLSLDPHFSHDGTSSGDSSSGGLTSQESTMERQK-PEP 1222
Query: 1182 KWHGPP----SKVLGSY-KERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSN-TSS 1235
WH P S + GS + ++D + KDSPN+ S G+ SSHSSSNTLSSN +SS
Sbjct: 1223 LWHVPAQARLSAIAGSSGNKHPSRQDAAGKDSPNRHSK-GEPQYSSHSSSNTLSSNASSS 1281
Query: 1236 NSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTA----------------PCMPATILG 1279
+SDD+ F D ++PE L+ KG S+DSGIDT P P G
Sbjct: 1282 HSDDRWFDPLDPLEPEQDPLS--KGGSSDSGIDTTLYTSSPSCMSLAKAPRPAKPHKPPG 1339
Query: 1280 PVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTI--SAGSAAEGSMGDLS 1337
+ L G R+ +VS PA GY + S S G G
Sbjct: 1340 SMGLCGGGREAAGRSHHADRRREVS---PAPAVAGQSKGYRPKLYSSGSSTPTGLAGGSR 1396
Query: 1338 EISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKP-YHRQGAVNKY 1396
+ S A K++ S ++ + ++ S Q+ S+ K + +Q NK+
Sbjct: 1397 DPPRQPSDMGSRVGYPAQVYKTA-SAETPRPSQLAQPSPFQLSASVPKSFFSKQPVRNKH 1455
Query: 1397 VIGWKKSEGSPP-------PEEPEVTECPGMYSE-------MDVMSTATQHQTVVGDAVA 1442
GWK++E PP P++ T ++ + D+ S +++ + D
Sbjct: 1456 PTGWKRTEEPPPRPLPFSDPKKQVDTNTKNVFGQPRLRASLRDLRSPRKNYKSTIED--- 1512
Query: 1443 ETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFG 1502
D KL++ D+ E+ R SP++ L RTLSDES+CS RR SF
Sbjct: 1513 ---------DLKKLIIMDNLGPEQERDT-----GQSPQKGLQRTLSDESLCSGRREPSFA 1558
Query: 1503 SSRSSVLDQALPNDILFSTTPPY-HSTLPPR---AHPAPSMG------------SLRNEF 1546
S L+ LP+D+LF++T + STLP R HP P +G ++
Sbjct: 1559 SPAG--LEPGLPSDVLFTSTCAFPSSTLPARRQHQHPHPPVGPGATPAAGSGFPEKKSTI 1616
Query: 1547 WFSDGSLSD----KSKCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHT 1602
S+ SL+D + DPGLMPLPDTA GL+W+ LV+AA+A+E
Sbjct: 1617 SASELSLADGRDRPLRRLDPGLMPLPDTAAGLEWSSLVNAAKAYE--------------- 1661
Query: 1603 SYLDQRVASFCTLTDMQHGQDLEGA-----QELPLCVDPGSGKEFMDTTGERSPSPLTGK 1657
QR S +L D D+ A L L P + + T E P LTGK
Sbjct: 1662 ---VQRAVSLFSLNDPALSPDIPPAHSPVHSHLSLERGPPTPRT-TPTMSEEPPLDLTGK 1717
Query: 1658 VNQLELILRQLQTDLRKEKQDKAVLQAEVQHLRQDNMRLQEESQTATAQLRKFTEWF 1714
V QLE++L+QL TDL+KEKQDK VLQ+EV LRQ+N RLQEESQ A+ QLRKF E F
Sbjct: 1718 VYQLEVMLKQLHTDLQKEKQDKVVLQSEVASLRQNNQRLQEESQAASEQLRKFAEIF 1774
>gi|206725526 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 617 bits (1590), Expect = e-176
Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%)
Query: 327 RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385
R FAHYDVQS+LF+ A R+ +G ++G A+++ Q
Sbjct: 114 RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152
Query: 386 DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445
S+DL+ P F E GGEG+ G
Sbjct: 153 --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184
Query: 446 LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505
+ NA VS+LE P+ + Y +EH DLGA YYRK+FYGKEHQN+FG+DE+
Sbjct: 185 VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237
Query: 506 LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565
LGPVAVS+RRE+ E + G+ +YRV RT++L TLRG I EDA+P G RGL
Sbjct: 238 LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291
Query: 566 LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625
+++LE+V P+LS CLR S SPKV LL LDEQ LSFQ K+GILYC+AGQ +EEEMY
Sbjct: 292 PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351
Query: 626 NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685
NN+ AGPAF +FL LLG VRLKGF YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+
Sbjct: 352 NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411
Query: 686 LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745
LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT +
Sbjct: 412 LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471
Query: 746 CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804
Y V VSR++D P FGP +P G F +A FR FLLAK +N E AA + +F AMATRT
Sbjct: 472 TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531
Query: 805 RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863
RQ+YL+DLA N VTT ++D++ +F +LG ++ + PR A L + G+++W V A
Sbjct: 532 RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589
Query: 864 FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912
+ A ++ CLLGIS E ++L+ VVFNC+CRDV+ WT + +
Sbjct: 590 GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649
Query: 913 FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972
++ RGE + L + + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V
Sbjct: 650 YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709
Query: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032
VE F FA AGLR G+RL+ +C + +L E LLR++ V V ++ P + G PRR
Sbjct: 710 HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769
Query: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058
SEL + + E L G+P E +T
Sbjct: 770 SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829
Query: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117
F + +L P S S P P+ P L A+ ++P + S + L
Sbjct: 830 EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881
Query: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162
SPS +P P + P+ ++ GSG LE
Sbjct: 882 PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926
Score = 63.5 bits (153), Expect = 2e-09
Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%)
Query: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557
S RSS+ D+A LPN D+L +TT PS+ S +E + S
Sbjct: 839 SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886
Query: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617
D G P P+ + + + S+ G L + + +AS C
Sbjct: 887 GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941
Query: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677
+ EG Q +P DP K + E P L+ KV+ LE +LR+LQ DL+KEK
Sbjct: 942 ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997
Query: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707
D+A L+ EV+ LR +N RLQ ES++A +L
Sbjct: 998 DRAALEEEVRSLRHNNRRLQAESESAATRL 1027
>gi|206725523 signal-induced proliferation-associated protein 1 [Homo
sapiens]
Length = 1042
Score = 617 bits (1590), Expect = e-176
Identities = 377/885 (42%), Positives = 499/885 (56%), Gaps = 121/885 (13%)
Query: 327 RCFAHYDVQSILFNINEAMATRAN-VGKRKNITTGASAASQTQMPTGQTGNCESPLGSKE 385
R FAHYDVQS+LF+ A R+ +G ++G A+++ Q
Sbjct: 114 RWFAHYDVQSLLFD----WAPRSQGMGSHSEASSGTLASAEDQ----------------- 152
Query: 386 DLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGESCSFESS 445
S+DL+ P F E GGEG+ G
Sbjct: 153 --------------AASSDLLHGAPGFVCELGGEGEL--------------GLGGPASPP 184
Query: 446 LSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDEN 505
+ NA VS+LE P+ + Y +EH DLGA YYRK+FYGKEHQN+FG+DE+
Sbjct: 185 VPPALPNAAVSILEEPQN-------RTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDES 237
Query: 506 LGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTLRGAILEDAIPSTARHGTARGLP 565
LGPVAVS+RRE+ E + G+ +YRV RT++L TLRG I EDA+P G RGL
Sbjct: 238 LGPVAVSLRREEKEGSGG--GTLHSYRVIVRTTQLRTLRGTISEDALPP----GPPRGLS 291
Query: 566 LKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMY 625
+++LE+V P+LS CLR S SPKV LL LDEQ LSFQ K+GILYC+AGQ +EEEMY
Sbjct: 292 PRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMY 351
Query: 626 NNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTL 685
NN+ AGPAF +FL LLG VRLKGF YRAQLD KTDSTGTHSLYTTY+D+E+MFHVST+
Sbjct: 352 NNQEAGPAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSLYTTYQDHEIMFHVSTM 411
Query: 686 LPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENV 745
LPY PNN+QQLLRKRHIGNDIVTIVFQEPG+ PF P +IRSHFQHVF++V+ H PCT +
Sbjct: 412 LPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHTPCTPHT 471
Query: 746 CYSVGVSRSKDVPPFGPPIPK-GVTFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRT 804
Y V VSR++D P FGP +P G F +A FR FLLAK +N E AA + +F AMATRT
Sbjct: 472 TYRVAVSRTQDTPAFGPALPAGGGPFAANADFRAFLLAKALNGEQAAGHARQFHAMATRT 531
Query: 805 RQEYLKDLAENFVTTATVDTSVKFSFITLGAKKKEKVKPR-KDAHLFSIGAIMWHVIARD 863
RQ+YL+DLA N VTT ++D++ +F +LG ++ + PR A L + G+++W V A
Sbjct: 532 RQQYLQDLATNEVTTTSLDSASRFGLPSLGGRR--RAAPRGPGAELQAAGSLVWGVRAAP 589
Query: 864 FGQSA-----------DIECLLGISNEFIMLIEKDSKNVVFNCSCRDVIGWTSGLVSIKV 912
+ A ++ CLLGIS E ++L+ VVFNC+CRDV+ WT + +
Sbjct: 590 GARVAAGAQASGPEGIEVPCLLGISAEALVLVAPRDGRVVFNCACRDVLAWTFSEQQLDL 649
Query: 913 FYERGECVLLSSVDNCAEDIREIVQRLVIVTRGCETVEMTLRRNGLGQLGFHVNFEGIVA 972
++ RGE + L + + + E+V RL +V+RGCET E+ L R+G G+LGF V+ EG V
Sbjct: 650 YHGRGEAITLRFDGSPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFVT 709
Query: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSPRR 1032
VE F FA AGLR G+RL+ +C + +L E LLR++ V V ++ P + G PRR
Sbjct: 710 HVERFTFAETAGLRPGARLLRVCGQTLPSLRPEAAAQLLRSAPKVCVTVLPPDESGRPRR 769
Query: 1033 GCSELCRIPMVEYK----------------------------LDSEGTP------CEYKT 1058
SEL + + E L G+P E +T
Sbjct: 770 SFSELYTLSLQEPSRRGAPDPVQDEVQGVTLLPTTKQLLHLCLQDGGSPPGPGDLAEERT 829
Query: 1059 PFRRNTTWHRVPTPALQPLSRAS-PIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGT 1117
F + +L P S S P P+ P L A+ ++P + S + L
Sbjct: 830 EFLHSQN-------SLSPRSSLSDEAPVLPNTTPDLLLATTAKPSVPSADS-ETPLTQDR 881
Query: 1118 RSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLE 1162
SPS +P P + P+ ++ GSG LE
Sbjct: 882 PGSPSGSEDKGNPAPELRASFLPRTLSLRNSISRIMSEAGSGTLE 926
Score = 63.5 bits (153), Expect = 2e-09
Identities = 66/210 (31%), Positives = 96/210 (45%), Gaps = 26/210 (12%)
Query: 1503 SSRSSVLDQA--LPN---DILFSTTPPYHSTLPPRAHPAPSMGSLRNEFWFSDGSLSDKS 1557
S RSS+ D+A LPN D+L +TT PS+ S +E + S
Sbjct: 839 SPRSSLSDEAPVLPNTTPDLLLATTAK------------PSVPSADSETPLTQDRPGSPS 886
Query: 1558 KCADPGLMPLPDTATGLDWTHLVDAARAFEGLDSDEELGLLCHHTSYLDQRVASFCTLTD 1617
D G P P+ + + + S+ G L + + +AS C
Sbjct: 887 GSEDKG-NPAPELRASF-LPRTLSLRNSISRIMSEAGSGTLEDEWQAISE-IASTCNT-- 941
Query: 1618 MQHGQDLEGAQELPLCVDPGSGKEFMDTTGERSPSPLTGKVNQLELILRQLQTDLRKEKQ 1677
+ EG Q +P DP K + E P L+ KV+ LE +LR+LQ DL+KEK
Sbjct: 942 ILESLSREG-QPIPESGDP---KGTPKSDAEPEPGNLSEKVSHLESMLRKLQEDLQKEKA 997
Query: 1678 DKAVLQAEVQHLRQDNMRLQEESQTATAQL 1707
D+A L+ EV+ LR +N RLQ ES++A +L
Sbjct: 998 DRAALEEEVRSLRHNNRRLQAESESAATRL 1027
>gi|156086740 GTPase activating Rap/RanGAP domain-like 4 isoform 2
[Homo sapiens]
Length = 715
Score = 230 bits (586), Expect = 1e-59
Identities = 135/333 (40%), Positives = 184/333 (55%), Gaps = 32/333 (9%)
Query: 487 YRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTS-----ELT 541
YR+ F GK+H N++ +LG + +S++ E E EG ++ RV R+ E
Sbjct: 142 YRRHFLGKDHLNFYCTGSSLGNLILSVKCE------EAEGIEY-LRVILRSKLKTVHERI 194
Query: 542 TLRGAILEDAIPSTARH--GTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLD 599
L G ++P A+ A GL VL PK S+ ++ D
Sbjct: 195 PLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLY-----------------PKASQMIVSYD 237
Query: 600 EQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDN 659
E ++ K G++Y KA Q+ EEE++ N PAF+EFLDLLG + L+ F +R LD
Sbjct: 238 EHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDV 297
Query: 660 KTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPF 719
TG S+YTT++D E+MFHVST LP+ + QQL RKRHIGNDIV I+FQE PF
Sbjct: 298 THGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENT-PF 356
Query: 720 TPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDF 779
P I S+F H +++V+V P TE Y V V+ +DVP FGPP+P F K FR+F
Sbjct: 357 VPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREF 416
Query: 780 LLAKVINAENAAHKSEKFRAMATRTRQEYLKDL 812
LL K+ NAENA KS+KF + RTR L +L
Sbjct: 417 LLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 449
>gi|156086724 GTPase activating Rap/RanGAP domain-like 4 isoform 1
[Homo sapiens]
Length = 730
Score = 230 bits (586), Expect = 1e-59
Identities = 135/333 (40%), Positives = 184/333 (55%), Gaps = 32/333 (9%)
Query: 487 YRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTS-----ELT 541
YR+ F GK+H N++ +LG + +S++ E E EG ++ RV R+ E
Sbjct: 157 YRRHFLGKDHLNFYCTGSSLGNLILSVKCE------EAEGIEY-LRVILRSKLKTVHERI 209
Query: 542 TLRGAILEDAIPSTARH--GTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLLKLD 599
L G ++P A+ A GL VL PK S+ ++ D
Sbjct: 210 PLAGLSKLPSVPQIAKAFCDDAVGLRFNPVLY-----------------PKASQMIVSYD 252
Query: 600 EQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDN 659
E ++ K G++Y KA Q+ EEE++ N PAF+EFLDLLG + L+ F +R LD
Sbjct: 253 EHEVNNTFKFGVIYQKARQTLEEELFGNNEESPAFKEFLDLLGDTITLQDFKGFRGGLDV 312
Query: 660 KTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPF 719
TG S+YTT++D E+MFHVST LP+ + QQL RKRHIGNDIV I+FQE PF
Sbjct: 313 THGQTGVESVYTTFRDREIMFHVSTKLPFTDGDAQQLQRKRHIGNDIVAIIFQEENT-PF 371
Query: 720 TPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDF 779
P I S+F H +++V+V P TE Y V V+ +DVP FGPP+P F K FR+F
Sbjct: 372 VPDMIASNFLHAYIVVQVETPGTETPSYKVSVTAREDVPTFGPPLPSPPVFQKGPEFREF 431
Query: 780 LLAKVINAENAAHKSEKFRAMATRTRQEYLKDL 812
LL K+ NAENA KS+KF + RTR L +L
Sbjct: 432 LLTKLTNAENACCKSDKFAKLEDRTRAALLDNL 464
>gi|224809582 RAP1 GTPase activating protein isoform c [Homo
sapiens]
Length = 663
Score = 221 bits (563), Expect = 5e-57
Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%)
Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543
A YRK F GKEH NY+ +D LG + S++ + + G Q + R+ RT T
Sbjct: 87 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 137
Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602
D IP + + + K V E V + L PK S ++ DE
Sbjct: 138 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 188
Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662
+S K G++Y K GQ++EEE+++ PAF EFL+ LGQ+V+L+ F +R LD
Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248
Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722
TGT S+Y +++ E+MFHVST LPY + QQL RKRHIGNDIV +VFQ+ PF P
Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 307
Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782
I S+F H +V+V+ + Y V V+ DVP FGPP+P F K F++FLL
Sbjct: 308 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 367
Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814
K+INAE A +K+EKF + RTR L+ L E
Sbjct: 368 KLINAEYACYKAEKFAKLEERTRAALLETLYE 399
>gi|224809578 RAP1 GTPase activating protein isoform a [Homo
sapiens]
Length = 727
Score = 221 bits (563), Expect = 5e-57
Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%)
Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543
A YRK F GKEH NY+ +D LG + S++ + + G Q + R+ RT T
Sbjct: 151 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 201
Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602
D IP + + + K V E V + L PK S ++ DE
Sbjct: 202 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 252
Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662
+S K G++Y K GQ++EEE+++ PAF EFL+ LGQ+V+L+ F +R LD
Sbjct: 253 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 312
Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722
TGT S+Y +++ E+MFHVST LPY + QQL RKRHIGNDIV +VFQ+ PF P
Sbjct: 313 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 371
Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782
I S+F H +V+V+ + Y V V+ DVP FGPP+P F K F++FLL
Sbjct: 372 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 431
Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814
K+INAE A +K+EKF + RTR L+ L E
Sbjct: 432 KLINAEYACYKAEKFAKLEERTRAALLETLYE 463
>gi|224809573 RAP1 GTPase activating protein isoform b [Homo
sapiens]
Length = 681
Score = 221 bits (563), Expect = 5e-57
Identities = 132/332 (39%), Positives = 182/332 (54%), Gaps = 20/332 (6%)
Query: 484 AYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFRTSELTTL 543
A YRK F GKEH NY+ +D LG + S++ + + G Q + R+ RT T
Sbjct: 87 ARIYRKHFLGKEHFNYYSLDAALGHLVFSLKYDVI-------GDQEHLRLLLRTKCRT-- 137
Query: 544 RGAILEDAIPSTARHGTARGLPL-KEVLEYVIPELSIQCLRQASNSPKVSEQLLKLDEQG 602
D IP + + + K V E V + L PK S ++ DE
Sbjct: 138 ----YHDVIPISCLTEFPNVVQMAKLVCEDVNVDRFYPVLY-----PKASRLIVTFDEHV 188
Query: 603 LSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQLDNKTD 662
+S K G++Y K GQ++EEE+++ PAF EFL+ LGQ+V+L+ F +R LD
Sbjct: 189 ISNNFKFGVIYQKLGQTSEEELFSTNEESPAFVEFLEFLGQKVKLQDFKGFRGGLDVTHG 248
Query: 663 STGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQEPGALPFTPK 722
TGT S+Y +++ E+MFHVST LPY + QQL RKRHIGNDIV +VFQ+ PF P
Sbjct: 249 QTGTESVYCNFRNKEIMFHVSTKLPYTEGDAQQLQRKRHIGNDIVAVVFQDENT-PFVPD 307
Query: 723 SIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSAVFRDFLLA 782
I S+F H +V+V+ + Y V V+ DVP FGPP+P F K F++FLL
Sbjct: 308 MIASNFLHAYVVVQAEGGGPDGPLYKVSVTARDDVPFFGPPLPDPAVFRKGPEFQEFLLT 367
Query: 783 KVINAENAAHKSEKFRAMATRTRQEYLKDLAE 814
K+INAE A +K+EKF + RTR L+ L E
Sbjct: 368 KLINAEYACYKAEKFAKLEERTRAALLETLYE 399
>gi|207448705 GTPase activating Rap/RanGAP domain-like 3 [Homo
sapiens]
Length = 1013
Score = 217 bits (552), Expect = 9e-56
Identities = 136/376 (36%), Positives = 202/376 (53%), Gaps = 31/376 (8%)
Query: 477 IEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQFNYRVAFR 536
+E+ + +Y K+F G+ HQNY G D P +S+ Q N RV
Sbjct: 89 LENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTL----------SDQNNQRVPQY 138
Query: 537 TSELTTLRGAILEDAIPSTARHGTARGLPLKEVLEYVIPELSIQCLRQASNSPKVSEQLL 596
+ L G + +P + + L +K +L + + + R+ + P++ + LL
Sbjct: 139 RAILWRKTGT-QKICLP----YSPTKTLSVKSILSAMNLDKFEKGPREIFH-PEIQKDLL 192
Query: 597 KLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKGFSKYRAQ 656
L+EQ S K G+L+ K GQ T++EM++NE F++FL+LLG + LKG++ YR
Sbjct: 193 VLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGG 252
Query: 657 LDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRKRHIGNDIVTIVFQ--EP 714
LD K D+TG HS+YT Y+ +E+MFHVST+LPY N+QQ+ RKRHIGNDIVTIVFQ E
Sbjct: 253 LDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEE 312
Query: 715 GALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGVTFPKSA 774
+ F P IRSHF H+F +V+ + +N Y + + + VP FGPP+P F
Sbjct: 313 SSPAFKPSMIRSHFTHIFALVRYNQ---QNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQ 369
Query: 775 VFRDFLLAKVINAENAAHKSEKFRAMATRT--------RQEYLKDLAENFVTTATVDTSV 826
FRDFLL K+IN E A ++ F RT Q+ + DL +N + + +
Sbjct: 370 EFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVL 429
Query: 827 KFSFITLGAKKKEKVK 842
S A+KKE+ +
Sbjct: 430 PES--PKSARKKEEAR 443
>gi|51230412 GTPase activating Rap/RanGAP domain-like 1 isoform 2
[Homo sapiens]
Length = 2083
Score = 74.3 bits (181), Expect = 9e-13
Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 11/235 (4%)
Query: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
K+ +L LD + HKI + Y GQ + + N A+E+F+ LG V L
Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850
Query: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
+ L K STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 1851 HCGFMGGL-QKNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907
Query: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
IV+ E + I + F V +++ +N +S+ + + +VP FGP +
Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVIYP----MKNHMFSIQIMKKPEVPFFGPLFDGAI 1962
Query: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVD 823
K V + A INA A R YL+ + ++ + T +
Sbjct: 1963 VNGK--VLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015
>gi|51226124 GTPase activating Rap/RanGAP domain-like 1 isoform 1
[Homo sapiens]
Length = 2036
Score = 74.3 bits (181), Expect = 9e-13
Identities = 63/235 (26%), Positives = 101/235 (42%), Gaps = 11/235 (4%)
Query: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
K+ +L LD + HKI + Y GQ + + N A+E+F+ LG V L
Sbjct: 1791 KLLRELRNLDSRQCRETHKIAVFYVAEGQEDKHSILTNTGGSQAYEDFVAGLGWEVNLTN 1850
Query: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
+ L K STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 1851 HCGFMGGL-QKNKSTGLTTPYFATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1907
Query: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
IV+ E + I + F V +++ +N +S+ + + +VP FGP +
Sbjct: 1908 IVWSE-HTRDYRRGIIPTEFGDVLIVIYP----MKNHMFSIQIMKKPEVPFFGPLFDGAI 1962
Query: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAENFVTTATVD 823
K V + A INA A R YL+ + ++ + T +
Sbjct: 1963 VNGK--VLPIMVRATAINASRALKSLIPLYQNFYEERARYLQTIVQHHLEPTTFE 2015
>gi|118600961 akt substrate AS250 [Homo sapiens]
Length = 1873
Score = 70.5 bits (171), Expect = 1e-11
Identities = 62/227 (27%), Positives = 101/227 (44%), Gaps = 11/227 (4%)
Query: 590 KVSEQLLKLDEQGLSFQHKIGILYCKAGQSTEEEMYNNETAGPAFEEFLDLLGQRVRLKG 649
K+ +L LD + HKI + Y GQ + + +NE A+E+F+ LG V L
Sbjct: 1630 KLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAGLGWEVDLST 1689
Query: 650 FSKYRAQLDNKTDSTGTHSLYTTYKDYELMFHVSTLLPYMPNNRQQLLRK-RHIGNDIVT 708
+ L + STG + Y E++FHVST +P ++ L +K RH+GND V
Sbjct: 1690 HCGFMGGL-QRNGSTGQTAPYYATSTVEVIFHVSTRMP--SDSDDSLTKKLRHLGNDEVH 1746
Query: 709 IVFQEPGALPFTPKSIRSHFQHVFVIVKVHNPCTENVCYSVGVSRSKDVPPFGPPIPKGV 768
IV+ E + + I + F V +I+ +N + + +++ +VP FGP +
Sbjct: 1747 IVWSE-HSRDYRRGIIPTAFGDVSIIIYP----MKNHMFFIAITKKPEVPFFGPLFDGAI 1801
Query: 769 TFPKSAVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEN 815
K + + A INA A R YL+ + +N
Sbjct: 1802 VSGK--LLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQN 1846
>gi|116256350 tuberous sclerosis 2 isoform 4 [Homo sapiens]
Length = 1740
Score = 66.6 bits (161), Expect = 2e-10
Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)
Query: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+
Sbjct: 1455 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1514
Query: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
+ LK + L D G +T ++M FH++TL+P ++ + +KRH
Sbjct: 1515 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1573
Query: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
+GND V+IV+ + G F +I+ F V VIV
Sbjct: 1574 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1606
>gi|116256352 tuberous sclerosis 2 isoform 1 [Homo sapiens]
Length = 1807
Score = 66.6 bits (161), Expect = 2e-10
Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)
Query: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+
Sbjct: 1522 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1581
Query: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
+ LK + L D G +T ++M FH++TL+P ++ + +KRH
Sbjct: 1582 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1640
Query: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
+GND V+IV+ + G F +I+ F V VIV
Sbjct: 1641 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1673
>gi|167412124 tuberous sclerosis 2 isoform 5 [Homo sapiens]
Length = 1784
Score = 66.6 bits (161), Expect = 2e-10
Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 7/154 (4%)
Query: 587 NSPKVSEQLLKLDEQGLSFQ-HKIGILYCKAGQSTEE-EMYNNETAGPAFEEFLDLLGQR 644
N + E+ ++L +Q S+ HKI +LY GQS E + +NE + EFL LG+
Sbjct: 1499 NESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRL 1558
Query: 645 VRLKGFSKYRAQLDNKTDSTGTHSLYTTYKDYELM---FHVSTLLPYMPNNRQQLLRKRH 701
+ LK + L D G +T ++M FH++TL+P ++ + +KRH
Sbjct: 1559 IELKDCQPDKVYLGG-LDVCGEDGQFTYCWHDDIMQAVFHIATLMPTKDVDKHRCDKKRH 1617
Query: 702 IGNDIVTIVFQEPGALPFTPKSIRSHFQHVFVIV 735
+GND V+IV+ + G F +I+ F V VIV
Sbjct: 1618 LGNDFVSIVYNDSGE-DFKLGTIKGQFNFVHVIV 1650
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
Length = 1747
Score = 48.9 bits (115), Expect = 4e-05
Identities = 58/243 (23%), Positives = 89/243 (36%), Gaps = 69/243 (28%)
Query: 973 DVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLR---TSVTVKVVII--QPHDD 1027
DVE G AW+AGLR G L+E+ V V + H+Q++ L+R + +KVV + +P +D
Sbjct: 630 DVE--GVAWRAGLRTGDFLIEVNGVNVVKVGHKQVVALIRQGGNRLVMKVVSVTRKPEED 687
Query: 1028 GSPRRGCSELCRIPMVEYKLDSEGTPCEYK------------------------------ 1057
G+ RR R P L S+ E +
Sbjct: 688 GARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEMLAAAAEPTLRPDIA 747
Query: 1058 ------TPFRRNTTWHRVPTPALQPLSRASPIPGTPDRLP---------------CQQLL 1096
++ T R+ + L +PG P++LP ++L
Sbjct: 748 DADSRAATVKQRPTSRRITPAEISSLFERQGLPG-PEKLPGSLRKGIPRTKSVGEDEKLA 806
Query: 1097 QQAQAAIPRSTSFDRKLPDGTRSSPSNQSS----------SSDPGPGGSGPWRPQVGYDG 1146
+ PRSTS + +G P Q++ S P P S P P YD
Sbjct: 807 SLLEGRFPRSTSMQDPVREGRGIPPPPQTAPPPPPAPYYFDSGPPPAFSPPPPPGRAYDT 866
Query: 1147 CQS 1149
+S
Sbjct: 867 VRS 869
Score = 31.6 bits (70), Expect = 7.0
Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 1080 ASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLP-DGTRSSPSNQSSSSDPGPGGSG 1136
ASP P LP Q LLQ+ Q R D++ G + + QS SDPGPG G
Sbjct: 387 ASPGPSLRS-LPHQLLLQRLQEEKDRDRDADQESNISGPLAGRAGQSKISDPGPGPGG 443
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 48.5 bits (114), Expect = 6e-05
Identities = 61/261 (23%), Positives = 92/261 (35%), Gaps = 16/261 (6%)
Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
D + SS SN SS+S S D S + S + + + D+
Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837
Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
+S ++ GS + + + D S + S + S SS SS + SSN+S
Sbjct: 838 SSDSSDSS-----DSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSS 892
Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294
+SD + D D + S+DS + S S S +
Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS-----------DNSNSSDSSNS 941
Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA 1354
+D++D S D S + S+ S S + S S S S S+
Sbjct: 942 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS 1001
Query: 1355 HCSKSSGSLDSSKVYIVSHSS 1375
+ S SS S DSS S SS
Sbjct: 1002 NSSDSSDSSDSSDSSNSSDSS 1022
Score = 47.8 bits (112), Expect = 9e-05
Identities = 75/318 (23%), Positives = 114/318 (35%), Gaps = 28/318 (8%)
Query: 1105 RSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECD 1164
+S S D D + SS S+ SS SD S D S S +
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 1165 GAREREDTMEASRHPETKWHGPPSKVLGS------------YKERALQKDGSCKDSPNKL 1212
+ + D+ ++S ++K S+ S + + D S + +
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665
Query: 1213 SHIGDKSCSSHSSSNTLSSNTSSNSDDKHFG----SGDLMDPELLGLTYIKGASTDSGID 1268
S D S SS SSS++ SSN+S +SD S D D + +S + D
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725
Query: 1269 TAPCMPATILGPVHLA----------GSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHG 1318
+ + + + S S S + +D++D S D S
Sbjct: 726 SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785
Query: 1319 YASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHS--SG 1376
S+ S+ S+ + D S S S S S S S++ S SS S DSS S S S
Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS 845
Query: 1377 QQVPGSMSKPYHRQGAVN 1394
GS S +R + N
Sbjct: 846 DSSDGSDSDSSNRSDSSN 863
Score = 42.4 bits (98), Expect = 0.004
Identities = 65/263 (24%), Positives = 98/263 (37%), Gaps = 8/263 (3%)
Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
D + SS S++SS+S S D S + S D + + +
Sbjct: 916 DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS----DSSNSSDSSDS 971
Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
S + S + + D S + S D S SS SS+++ SSN+S
Sbjct: 972 NSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSS 1031
Query: 1235 SNSDDKHFG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSR 1293
+SD S D D + S+DS D++ ++ S S S
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS-DSSDSSDSSDSSD-SSDSSESSDSSD 1089
Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSP 1352
+ +D++D S D S S+ S+ S+ D S+ S S+ S S S
Sbjct: 1090 SSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSE 1149
Query: 1353 SAHCSKSSGSLDSSKVYIVSHSS 1375
S+ S SS S DSS S SS
Sbjct: 1150 SSDSSDSSDSSDSSDSSDSSDSS 1172
Score = 40.4 bits (93), Expect = 0.015
Identities = 61/253 (24%), Positives = 93/253 (36%), Gaps = 26/253 (10%)
Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
D + SS S+ SS S S D S S + + + D+ E
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS--------SDSSDSSDSSDSSDSSE 1083
Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
+S ++ + S + + D S + S+ D S SS SS ++ SSN+S
Sbjct: 1084 SSDSSDSS-NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 1142
Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294
+SD S D D + S+DS + S S S +
Sbjct: 1143 DSSDSSE--SSDSSDSSDSSDSSDSSDSSDSSDSS--------------DSSNSSDSSDS 1186
Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSPS 1353
+D++D S D S S+ S+ S+ D S+ + S S S S S
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246
Query: 1354 AHCSKSSGSLDSS 1366
++ S SS S DSS
Sbjct: 1247 SNSSDSSDSSDSS 1259
Score = 38.5 bits (88), Expect = 0.057
Identities = 59/261 (22%), Positives = 94/261 (36%), Gaps = 21/261 (8%)
Query: 1115 DGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
D + SS S+ S SSD S D S + S + + + D+ +
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS--DSSNSSDSSDSSD 760
Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTS 1234
+S ++ S D S N S+ D S SS+SS SSN+S
Sbjct: 761 SSNSSDSSDSSDSSD----------SSDSSNSSDSNDSSNSSDSSDSSNSSD---SSNSS 807
Query: 1235 SNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRA 1294
+SD D + + S+DS + + + S S S +
Sbjct: 808 DSSDSSDSSDSDSSN------SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861
Query: 1295 EQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA 1354
+D++D S + S S+ S+ S+ + D S +S S S+
Sbjct: 862 SNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSS 921
Query: 1355 HCSKSSGSLDSSKVYIVSHSS 1375
S+SS S D+S S+SS
Sbjct: 922 DSSESSNSSDNSNSSDSSNSS 942
Score = 36.2 bits (82), Expect = 0.28
Identities = 61/282 (21%), Positives = 99/282 (35%), Gaps = 49/282 (17%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTME- 1174
G +S P N+ S+ G + +D QG P D + +D
Sbjct: 427 GQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSM------QGDDPNSSDESNGNDDANSE 480
Query: 1175 ----ASRHPETKWHGPPSKVLGSYKERALQKD-----------------GSCKDSPNKLS 1213
+S + ++ SK G+ + +D G+ + N S
Sbjct: 481 SDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS 540
Query: 1214 HIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCM 1273
G S S ++ SSN+S +SD S D +S+DS D++
Sbjct: 541 DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSD------------SNSSSDS--DSSDSD 586
Query: 1274 PATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSM 1333
+ S S S + +D++D S D + +S + S+ S
Sbjct: 587 SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSD-------SSKSESDSSDSDSK 639
Query: 1334 GDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSS 1375
D S+ +S S + S S++ S SS S DSS S SS
Sbjct: 640 SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSS 681
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
Length = 2161
Score = 45.8 bits (107), Expect = 4e-04
Identities = 45/198 (22%), Positives = 81/198 (40%), Gaps = 38/198 (19%)
Query: 974 VEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLR---TSVTVKVVIIQPH---DD 1027
V+ G AW+AGLR G L+E+ V + H Q+++++R ++ VKVV++ H D+
Sbjct: 705 VDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDE 764
Query: 1028 GSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTP 1087
++ + R+P L S+ E + ++ + +P+P
Sbjct: 765 AVHKKAPQQAKRLPPPTISLRSKSMTSELE---------------EMEYEQQPAPVPSME 809
Query: 1088 DRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGG---SGPWRPQVGY 1144
+ Q+ KL + ++ S+S PGPGG G RP+ G+
Sbjct: 810 KKRTVYQMAL-------------NKLDEILAAAQQTISASESPGPGGLASLGKHRPK-GF 855
Query: 1145 DGCQSPLLLEHQGSGPLE 1162
+S H+ E
Sbjct: 856 FATESSFDPHHRAQPSYE 873
>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
Length = 1497
Score = 43.5 bits (101), Expect = 0.002
Identities = 65/252 (25%), Positives = 97/252 (38%), Gaps = 34/252 (13%)
Query: 1310 PAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS-GSPSAHCSKSSGSLDSSKV 1368
P K + +GYA T S G GS + ++ SSG +S GS H S SS
Sbjct: 31 PPKGGTSNGYAKTASLGG---GSRLEKQSLTHGSSGYINSTGSTRGHASTSS-------- 79
Query: 1369 YIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMS 1428
Y +HS +P S + R+ V ++ S G+ PE P E S
Sbjct: 80 YRRAHSPASTLPNSPGSTFERKTHVTRHAYE-GSSSGNSSPEYPR--------KEFASSS 130
Query: 1429 TATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLS 1488
T + QT + Q + + L D + +G R S +SP R+ TL
Sbjct: 131 TRGRSQTRESEIRVRLQSASPSTRWTE--LDDVKRLLKGSRSAS----VSPTRNSSNTLP 184
Query: 1489 -------DESICSNRRGSSFGSSRSSVLDQALPNDILFSTTPPYHSTLPPRAHPAPSMGS 1541
+ I + S G+ +++LD LP+ + ST P S + S
Sbjct: 185 IPKKGTVETKIVTASSQSVSGTYDATILDANLPSHVWSSTLPAGSSMGTYHNNMTTQSSS 244
Query: 1542 LRNEFWFSDGSL 1553
L N +S GS+
Sbjct: 245 LLNTNAYSAGSV 256
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 43.1 bits (100), Expect = 0.002
Identities = 53/186 (28%), Positives = 78/186 (41%), Gaps = 25/186 (13%)
Query: 970 IVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGS 1029
IV +VE A +AGL+ G + I V L H ++I+LL S + P ++ S
Sbjct: 984 IVWNVEEGSPACQAGLKAGDLITHINGEPVHGLVHTEVIELLLKSGNKVSITTTPFENTS 1043
Query: 1030 ----PRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTTWHRVPTPAL----------Q 1075
P R S R+ K + + ++ F++ + P+P L +
Sbjct: 1044 IKTGPARRNSYKSRMVRRSKKSKKKESLERRRSLFKKLA---KQPSPLLHTSRSFSCLNR 1100
Query: 1076 PLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDP-GPGG 1134
LS +PG+ P L ++ RST P GT SS S+ SSS P P G
Sbjct: 1101 SLSSGESLPGS----PTHSLSPRSPTPSYRSTP---DFPSGTNSSQSSSPSSSAPNSPAG 1153
Query: 1135 SGPWRP 1140
SG RP
Sbjct: 1154 SGHIRP 1159
Score = 31.2 bits (69), Expect = 9.1
Identities = 24/97 (24%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Query: 1320 ASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSA----HCSKSSGSLDSSKVYIVSHSS 1375
AS S+ +++ + G + E+ + S+ H P+ H +KS SL S +V + S
Sbjct: 2286 ASAASSDTSSAKAAGGMLELPAPSNRDHRKAQPAGEGRTHMTKSD-SLPSFRVSTLPLES 2344
Query: 1376 GQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEP 1412
P +M HR A++ + P P +P
Sbjct: 2345 HHPDPNTMGGASHRDRALSVTATVGETKGKDPAPAQP 2381
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 42.7 bits (99), Expect = 0.003
Identities = 22/59 (37%), Positives = 38/59 (64%), Gaps = 3/59 (5%)
Query: 971 VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRT---SVTVKVVIIQPHD 1026
V+ V P G A +AG+R+G R++E+ V V TH+Q++DL+R + + V+ + PH+
Sbjct: 81 VSAVLPGGAADRAGVRKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVPPHE 139
>gi|169173184 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1230
Score = 41.6 bits (96), Expect = 0.007
Identities = 84/350 (24%), Positives = 118/350 (33%), Gaps = 45/350 (12%)
Query: 1113 LPDGTRSSPSNQSSSSDPGPGGSGP---WRPQVGYDGCQSPLLLEHQGSGPL---ECDGA 1166
+P +SPS +S+ G + P W G SP S GA
Sbjct: 126 IPSAFWASPSASGASTPSDSGWASPSASWASTSSDSGWASPSASWTSPSASCASSSASGA 185
Query: 1167 REREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCS--SHS 1224
D+ AS P W P + S SP+ S S + S
Sbjct: 186 STPSDSGWAS--PSVFWVSPST---------------SWASSPSDFGWASTPSDSGWASS 228
Query: 1225 SSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLA 1284
S++ +S + S S G + T S+DSG ++ +I
Sbjct: 229 SASCISPSASGASTSSDSGWASPSASWVSTSTSRASTSSDSGWASSSASWDSITSDSGWV 288
Query: 1285 GSRSLIHSRAEQWADAADVSG---PDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISS 1341
+ S + WA A SG P A SV G+AS ++G++A G S +S
Sbjct: 289 CPSASWASSSASWASAPSDSGSSSPSVSRASTLSVSGWASFSASGASAPSDSGWTSHSAS 348
Query: 1342 HSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGW- 1400
S + SG S S +S S D SG P + GA GW
Sbjct: 349 GVSTTSDSGWASPSASGASTSSD----------SGWASPSASWASPSASGASTPSDSGWA 398
Query: 1401 -KKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLS 1449
+ G+ P P + CPG TA TVVG + H +S
Sbjct: 399 SPSASGASMPSAPSL--CPG---SCFPQLTARTGFTVVGFPFSLLSHCIS 443
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 41.2 bits (95), Expect = 0.009
Identities = 102/419 (24%), Positives = 141/419 (33%), Gaps = 72/419 (17%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYD-GCQSPLLLEHQGSGPLECDGAREREDTME 1174
G S S QSSS P GSG + Y+ G L HQ S + G + +
Sbjct: 546 GRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSG 605
Query: 1175 AS----RHPETK-------WHGPPSKVLGSY---------KERALQKDGSCKDSPNKLSH 1214
S +H T HG S S+ R Q+ SP++ H
Sbjct: 606 HSSTHGQHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRH 665
Query: 1215 IGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMP 1274
D SS + S SS++ SG + G + G+ SG
Sbjct: 666 GSDFGHSSSYGQHGSGSGWSSSNGPHGSVSG-----QSSGFGHKSGSGQSSGYSQHGSGS 720
Query: 1275 ATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-M 1333
+ G GSRS SR+EQ ++ +S Y HG S S+G +GS
Sbjct: 721 SHSSG-YRKHGSRSGQSSRSEQHGSSSGLSSS-------YGQHGSGSHQSSGHGRQGSGS 772
Query: 1334 GDLSEISSHSSGSHHSGSPSAH-----CSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYH 1388
G H S S HS S H CS S G +S + GQ GS + Y
Sbjct: 773 GHSPSRVRHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQ--ASGFGQHESGS-GQGYS 829
Query: 1389 RQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVL 1448
+ G+ + G S+G S S++ QH + G + + QH
Sbjct: 830 QHGSAS----GHFSSQGRHG-------------STSGQSSSSGQHDSSSGQSSSYGQHES 872
Query: 1449 SKEDFLKLMLPDSPLVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRSS 1507
+ GR + SP + S +S R GS G S SS
Sbjct: 873 ASHH------------ASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSS 919
Score = 41.2 bits (95), Expect = 0.009
Identities = 71/284 (25%), Positives = 96/284 (33%), Gaps = 29/284 (10%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173
G S S+QSSS GSG P R + G S +H R +
Sbjct: 1807 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 1866
Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228
++S H + W G GS + ++ GS ++ G S SS S
Sbjct: 1867 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYGQH 1926
Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
S + S +H GSG P + G+ S GP S
Sbjct: 1927 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSY-----------GPYGSGSGWS 1974
Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347
E + + G + + S +G + S S+ G G S SS S G H
Sbjct: 1975 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSS-SCGQHG 2033
Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390
SG S+H SGS SS G+Q GS P H Q
Sbjct: 2034 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 2070
Score = 38.9 bits (89), Expect = 0.044
Identities = 70/284 (24%), Positives = 95/284 (33%), Gaps = 29/284 (10%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173
G R S S+QSS GSG P R + G S +H R +
Sbjct: 1337 GHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 1396
Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228
++S H + W G GS + ++ GS ++ G S SS S
Sbjct: 1397 QSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 1456
Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
S + S +H GSG P + G+ S P S
Sbjct: 1457 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSYS-----------PYGSGSGWS 1504
Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347
E + + G + + S +G + S S+ G G S SS S G H
Sbjct: 1505 SSRGPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSS-SCGQHG 1563
Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390
SG S+H SGS SS G+Q GS P H Q
Sbjct: 1564 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 1600
Score = 38.9 bits (89), Expect = 0.044
Identities = 70/284 (24%), Positives = 95/284 (33%), Gaps = 29/284 (10%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTM 1173
G S S+QSSS GSG P R + G S +H R +
Sbjct: 2277 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336
Query: 1174 EAS---RHPETKWH--GPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNT 1228
++S H + W G GS + ++ GS ++ G S SS S
Sbjct: 2337 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 2396
Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
S + S +H GSG P + G+ S P S
Sbjct: 2397 GSGSRQSLGHGQH-GSGSGQSPSPSRGRHGSGSGQSSSYS-----------PYGSGSGWS 2444
Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSH- 1347
E + + G + + S +G + S S+ G G S SS S G H
Sbjct: 2445 SSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSS-SCGQHG 2503
Query: 1348 -HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQ 1390
SG S+H SGS SS G+Q GS P H Q
Sbjct: 2504 ASSGQSSSHGQHGSGSSQSS-------GYGRQGSGSGQSPGHGQ 2540
Score = 37.4 bits (85), Expect = 0.13
Identities = 77/311 (24%), Positives = 100/311 (32%), Gaps = 68/311 (21%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
G S S SSS+ P SG G GSG G R+
Sbjct: 676 GQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQ 735
Query: 1176 SRHPETKWHGPPSKVLGSYKERAL---QKDGSCKD------SPNKLSHIGDKSCSSHSSS 1226
S E HG S + SY + Q G + SP+++ H S S HSSS
Sbjct: 736 SSRSEQ--HGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRH---GSSSGHSSS 790
Query: 1227 NTL-SSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAG 1285
+ S TS +S H+ SG G ++ G H +G
Sbjct: 791 HGQHGSGTSCSSSCGHYESGS-------------GQASGFG--------------QHESG 823
Query: 1286 SRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSS 1344
S + ++ SG + HG S S+ S + S G S H S
Sbjct: 824 S-------GQGYSQHGSASGHFSSQGR----HGSTSGQSSSSGQHDSSSGQSSSYGQHES 872
Query: 1345 GSHH----------SGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVN 1394
SHH SG H + SGS S SG+ S S H G+
Sbjct: 873 ASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGR----SSSSGRHGSGSGQ 928
Query: 1395 KYVIGWKKSEG 1405
G K S G
Sbjct: 929 SSGFGHKSSSG 939
Score = 37.4 bits (85), Expect = 0.13
Identities = 29/77 (37%), Positives = 34/77 (44%), Gaps = 3/77 (3%)
Query: 1317 HGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSS- 1375
HG S S+G + S G S + H SGS HS S H S+S S S + S SS
Sbjct: 922 HGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSS 981
Query: 1376 --GQQVPGSMSKPYHRQ 1390
GQ GS H Q
Sbjct: 982 SYGQHGSGSRQSLGHGQ 998
Score = 37.4 bits (85), Expect = 0.13
Identities = 90/366 (24%), Positives = 120/366 (32%), Gaps = 61/366 (16%)
Query: 1116 GTRSSPSNQS--------SSSDPGPGGSGPWRP----QVGYDGCQSPLLLEHQ---GSGP 1160
G+RS S++S SSS G GSG + Q G QSP + GSG
Sbjct: 961 GSRSGQSSRSEQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQ 1020
Query: 1161 LECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDK 1218
G +SR P G S LG + R+ Q G + S S G
Sbjct: 1021 SSSYGPYRSGSGWSSSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1079
Query: 1219 SCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATIL 1278
+S SS+ SS H G G+S SG
Sbjct: 1080 GSTSGQSSSCGQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ-- 1124
Query: 1279 GPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLS 1337
P H G R ++ + SG + HG S+G E S G S
Sbjct: 1125 SPGH--GQRGSGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSS 1178
Query: 1338 EISSHSSGSHHSGSPSAHCSKSS--------GSLDSSKVYIVSHSSGQQVPGSMSKPYHR 1389
S H SGS HS H S+S GS S + H SG + S + R
Sbjct: 1179 SYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR----QSSGHGR 1234
Query: 1390 QGAVNKYV---------IGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDA 1440
QG+ + + +G S G + S S QH++ G +
Sbjct: 1235 QGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHS 1294
Query: 1441 VAETQH 1446
A +QH
Sbjct: 1295 SAYSQH 1300
Score = 37.0 bits (84), Expect = 0.17
Identities = 98/404 (24%), Positives = 132/404 (32%), Gaps = 80/404 (19%)
Query: 1116 GTRSSPSNQSSSSD---PGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDG--ARERE 1170
G S S QSSS+D G G S + G S GSG G
Sbjct: 206 GQHGSGSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSG 265
Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLS 1230
+ RH + GS ++L S SH+ S S HSSS+
Sbjct: 266 QSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQH 325
Query: 1231 SNTSSNSDDK-HFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSL 1289
+ SS S + H+ SG G ++ G H +GS
Sbjct: 326 GSGSSYSYSRGHYESG-------------SGQTSGFG--------------QHESGS--- 355
Query: 1290 IHSRAEQWADAADVSGPDDEPAKLYSVHGYASTI---SAGSAAEGSMGDLSEISSHSSG- 1345
++ ++ SG + S G AS+ + S S G S HSSG
Sbjct: 356 --GQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGR 413
Query: 1346 ---SHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKK 1402
S SG H + SGS S SSGQ G + R + YV G
Sbjct: 414 GQHSSGSGQSPGHGQRGSGSGQSP-------SSGQHGTG-----FGRSSSSGPYVSGSGY 461
Query: 1403 SEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDSP 1462
S G E S + S TQH + G + QH S
Sbjct: 462 SSGFGHHE-----------SSSEHSSGYTQHGSGSGHSSGHGQHG-----------SRSG 499
Query: 1463 LVEEGRRKFSFYGNLSPRRSLYRTLSDESICSNRRGSSFGSSRS 1506
G R+ S G+ S + + S +S+ +R GS G S S
Sbjct: 500 QSSRGERQGSSAGS-SSSYGQHGSGSRQSLGHSRHGSGSGQSPS 542
Score = 36.6 bits (83), Expect = 0.22
Identities = 59/213 (27%), Positives = 74/213 (34%), Gaps = 23/213 (10%)
Query: 1314 YSVHGYASTISAGSAAEGSMGDLSEI---------SSHSSGSHHSGSPSA--HCSKSSGS 1362
YS HG S S+G GS S SS S G H SGS + H + SGS
Sbjct: 244 YSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGSGS 303
Query: 1363 LDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSPPPEEPEVTECPGMYS 1422
S V H SG S S H G+ Y G +S + G S
Sbjct: 304 RQSPS--HVRHGSGS--GHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSS 359
Query: 1423 EMDV-------MSTATQHQTVVGDAVAETQHVLSKEDFLKLMLPDS-PLVEEGRRKFSFY 1474
S+ QH + G A + QH S +S GR + S
Sbjct: 360 GYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSG 419
Query: 1475 GNLSPRRSLYRTLSDESICSNRRGSSFGSSRSS 1507
SP + S +S S + G+ FG S SS
Sbjct: 420 SGQSPGHGQRGSGSGQSPSSGQHGTGFGRSSSS 452
Score = 36.6 bits (83), Expect = 0.22
Identities = 74/281 (26%), Positives = 99/281 (35%), Gaps = 29/281 (10%)
Query: 1122 SNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPET 1181
S+ SSS G GSG R +G+ S G P G E +S
Sbjct: 509 SSAGSSSSYGQHGSGS-RQSLGHSRHGSG-----SGQSPSPSRGRHESGSRQSSS----- 557
Query: 1182 KWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKH 1241
+GP G R + GS S L H +S S SS+ S++ +H
Sbjct: 558 --YGPHGYGSGRSSSRGPYESGSGHSSG--LGHQESRSGQSSGYGQHGSSSGHSSTHGQH 613
Query: 1242 FG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADA 1300
SG G T G S+ G + ++ G +S SR +D
Sbjct: 614 GSTSGQSSSCGQHGAT--SGQSSSHGQHGSGSSQSSRYGQQGSGSGQS--PSRGRHGSDF 669
Query: 1301 ADVS-----GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAH 1355
S G + HG S S+G + G S S H SGS HS H
Sbjct: 670 GHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKH 729
Query: 1356 CSKSSGSLDSSK---VYIVSHSSGQQVPGS-MSKPYHRQGA 1392
S+S S S + +S S GQ GS S + RQG+
Sbjct: 730 GSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGS 770
Score = 36.2 bits (82), Expect = 0.28
Identities = 66/279 (23%), Positives = 90/279 (32%), Gaps = 31/279 (11%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
G R S S QS S GSG + G P L E G G E + +
Sbjct: 2069 GQRGSGSRQSPSYGRHGSGSG----RSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHG 2124
Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235
S + +G G ++ GS S ++ G S S S + S
Sbjct: 2125 SGSGHSSGYGQHGSRSGQSSRG--ERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHS 2182
Query: 1236 NSDDKH-FGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGP------------VH 1282
S +H GSG G G S+ G + +++ G H
Sbjct: 2183 PSRGRHGSGSGHSSSHGQHGSG--SGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQH 2240
Query: 1283 LAGSRSLI----HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDLS 1337
+GS H + D G + + HG S+ S+ +GS G
Sbjct: 2241 GSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSP 2300
Query: 1338 EISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSG 1376
H SGS HS S H S S S S + H SG
Sbjct: 2301 SRGRHGSGSGHSSSYGQHGSGSGWSSSSGR-----HGSG 2334
Score = 35.8 bits (81), Expect = 0.37
Identities = 72/302 (23%), Positives = 95/302 (31%), Gaps = 26/302 (8%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
G+ SPS G G S + P G S GSG G RE +
Sbjct: 2412 GSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSS 2471
Query: 1176 --SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSS-NTLSSN 1232
+H + H GS ++ S SH S SS SS S
Sbjct: 2472 GYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSG 2531
Query: 1233 TSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLI-- 1290
+ + GSG P G S+ SG + ++ G + +S
Sbjct: 2532 SGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYS 2591
Query: 1291 --------------HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGD 1335
H + + G + Y HG S S+G +GS G
Sbjct: 2592 QHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQ 2651
Query: 1336 LSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVY--IVSHSS--GQQVPGS-MSKPYHRQ 1390
H SG HS S H S SG S Y + HSS GQ GS S Y +
Sbjct: 2652 SPSRGRHGSGLGHSSSHGQHGS-GSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710
Query: 1391 GA 1392
G+
Sbjct: 2711 GS 2712
Score = 35.0 bits (79), Expect = 0.63
Identities = 77/285 (27%), Positives = 95/285 (33%), Gaps = 36/285 (12%)
Query: 1122 SNQSSSSDPGPGGSGPWRP----QVGYDGCQSPLLLEHQ---GSGPLECDGAREREDTME 1174
S+ SSS G GSG + Q G QSP + GSG G
Sbjct: 1915 SSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWS 1974
Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNTLSSN 1232
+SR P G S LG + R+ Q G + S S G +S SS+
Sbjct: 1975 SSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHG 2033
Query: 1233 TSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHS 1292
SS H G G+S SG P H G R
Sbjct: 2034 ASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRGSGSR 2076
Query: 1293 RAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSHHSGS 1351
++ + SG + HG S+G E S G S S H SGS HS
Sbjct: 2077 QSPSYGRHGSGSGRSSSSGQ----HGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSG 2132
Query: 1352 PSAHCSKSSGSLDSSKVYIVSHSS---GQQVPGSMSKPYH-RQGA 1392
H S+S S + S SS GQ GS H RQG+
Sbjct: 2133 YGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGS 2177
Score = 35.0 bits (79), Expect = 0.63
Identities = 86/356 (24%), Positives = 112/356 (31%), Gaps = 67/356 (18%)
Query: 1111 RKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERE 1170
+ L G S S QS S G GSG G SP GSG
Sbjct: 2402 QSLGHGQHGSGSGQSPSPSRGRHGSGS-----GQSSSYSPY-----GSG----------- 2440
Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNT 1228
+SR P G S LG + R+ Q G + S S G +S SS+
Sbjct: 2441 SGWSSSRGPYESGSGHSSG-LGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 2499
Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
SS H G G+S SG P H G R
Sbjct: 2500 GQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRG 2542
Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSH 1347
++ + SG + HG S+G E S G S S H SGS
Sbjct: 2543 SGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 2598
Query: 1348 HSGSPSAHCSKSS--------GSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYV-- 1397
HS H S+S GS S + H SG + S + RQG+ +
Sbjct: 2599 HSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSR----QSSGHGRQGSGSGQSPS 2654
Query: 1398 -------IGWKKSEGSPPPEEPEVTECPGMYSEMDVMSTATQHQTVVGDAVAETQH 1446
+G S G + S + S QH++ G + A +QH
Sbjct: 2655 RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQH 2710
Score = 34.7 bits (78), Expect = 0.82
Identities = 74/300 (24%), Positives = 93/300 (31%), Gaps = 32/300 (10%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVG-YDGCQSPLLLEHQGSGPLECDGAREREDTME 1174
G S S QSSS P GSG W G Y+ S G G E +
Sbjct: 1482 GRHGSGSGQSSSYSPYGSGSG-WSSSRGPYESGSS----HSSGLGHRESRSGQSSGYGQH 1536
Query: 1175 ASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSS-NTLSSNT 1233
S + HG G S + S SH S SS SS S +
Sbjct: 1537 GSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSS----SHGQHGSGSSQSSGYGRQGSGS 1592
Query: 1234 SSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLI--- 1290
+ GSG P G S+ SG + ++ G + +S
Sbjct: 1593 GQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQ 1652
Query: 1291 -------------HSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDL 1336
H + + G + Y HG S S+G +GS G
Sbjct: 1653 HGSGSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGSGSGQS 1712
Query: 1337 SEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVS-HSS--GQQVPGS-MSKPYHRQGA 1392
H SG HS S H S S S S HSS GQ GS S Y + G+
Sbjct: 1713 PSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS 1772
Score = 34.3 bits (77), Expect = 1.1
Identities = 77/289 (26%), Positives = 92/289 (31%), Gaps = 50/289 (17%)
Query: 1111 RKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERE 1170
+ L G S S QS S G GSG G SP GSG G E
Sbjct: 1462 QSLGHGQHGSGSGQSPSPSRGRHGSGS-----GQSSSYSPY---GSGSGWSSSRGPYE-- 1511
Query: 1171 DTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCK--DSPNKLSHIGDKSCSSHSSSNT 1228
S H S LG + R+ Q G + S S G +S SS+
Sbjct: 1512 ---SGSSH---------SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 1559
Query: 1229 LSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
SS H G G+S SG P H G R
Sbjct: 1560 GQHGASSGQSSSHGQHGS-------------GSSQSSGYGRQGSGSGQ--SPGH--GQRG 1602
Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAA-EGSMGDLSEISSHSSGSH 1347
++ + SG + HG S+G E S G S S H SGS
Sbjct: 1603 SGSRQSPSYGRHGSGSGRSSSSGQ----HGSGLGESSGFGHHESSSGQSSSYSQHGSGSG 1658
Query: 1348 HSGSPSAHCSKSSGSLDSSKVYIVSHSS---GQQVPGSMSKPYH-RQGA 1392
HS H S+S S + S SS GQ GS H RQG+
Sbjct: 1659 HSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGSGSRQSSGHGRQGS 1707
Score = 33.5 bits (75), Expect = 1.8
Identities = 67/275 (24%), Positives = 92/275 (33%), Gaps = 27/275 (9%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGARERED---- 1171
G+R SPS+ S G S Q G G H SG + G + E
Sbjct: 302 GSRQSPSHVRHGSGSGHSSS---HGQHG-SGSSYSYSRGHYESGSGQTSGFGQHESGSGQ 357
Query: 1172 TMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSS 1231
+ S+H H GS +A S S+ +S S HSS S
Sbjct: 358 SSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHS 417
Query: 1232 NTSSNSD---DKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRS 1288
+ S S + GSG G + G S+ SG + G + +G
Sbjct: 418 SGSGQSPGHGQRGSGSGQSPSSGQHGTGF--GRSSSSG--------PYVSGSGYSSGFGH 467
Query: 1289 LIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSM-GDLSEISSHSSGSH 1347
H + + + G + + HG S S+ +GS G S H SGS
Sbjct: 468 --HESSSEHSSGYTQHGSGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSR 525
Query: 1348 HSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPGS 1382
S S H S S S S+ H SG + S
Sbjct: 526 QSLGHSRHGSGSGQSPSPSR---GRHESGSRQSSS 557
Score = 32.7 bits (73), Expect = 3.1
Identities = 63/264 (23%), Positives = 85/264 (32%), Gaps = 40/264 (15%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
G S S QSSS GSG GY +H G R + +
Sbjct: 1638 GHHESSSGQSSSYSQHGSGSGH---SSGYG--------QHGSRSGQSSRGERHGSSSRSS 1686
Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSH-IGDKSCSSHSSSNTLSSNTS 1234
SR+ + HG S+ + Q GS + SP++ H G SSH + S +S
Sbjct: 1687 SRYGQ---HGSGSRQSSGHGR---QGSGSGQ-SPSRGRHGSGLGHSSSHGQHGSGSGRSS 1739
Query: 1235 SNSD-DKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSR 1293
S + G + G + S G H H
Sbjct: 1740 SRGPYESRSGHSSVFGQHESGSGHSSAYSQHGS------------GSGHFCSQGQ--HGS 1785
Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS-MGDLSEISSHSSGSHHSGSP 1352
+ D G + + HG S+ S+ +GS G H SGS HS S
Sbjct: 1786 TSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSY 1845
Query: 1353 SAHCSKSSGSLDSSKVYIVSHSSG 1376
H S S S S + H SG
Sbjct: 1846 GQHGSGSGWSSSSGR-----HGSG 1864
Score = 32.0 bits (71), Expect = 5.3
Identities = 44/162 (27%), Positives = 54/162 (33%), Gaps = 21/162 (12%)
Query: 1291 HSRAEQWADAADVS-GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSSGSHHS 1349
H + W + G + Y HG S G ++ G S SS S G H S
Sbjct: 1403 HHESSSWQSSGCTQHGSGSGHSSSYEQHGSRS----GQSSRGERHGSSSGSSSSYGQHGS 1458
Query: 1350 GSPSA--HCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGWKKSEGSP 1407
GS + H SGS S H SG S S PY GW S G
Sbjct: 1459 GSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYS-PYGSGS-------GWSSSRG-- 1508
Query: 1408 PPEEPEVTECPGM---YSEMDVMSTATQHQTVVGDAVAETQH 1446
P E + G+ S S QH + G + QH
Sbjct: 1509 -PYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQH 1549
Score = 32.0 bits (71), Expect = 5.3
Identities = 78/305 (25%), Positives = 98/305 (32%), Gaps = 31/305 (10%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEH-QGSGPLECDGAREREDT 1172
G S S QSS GSG P R + G S +H GSG G E
Sbjct: 2160 GQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSG 2219
Query: 1173 MEA--SRHPETKWHGPPSKVLGSYKERALQKD--GSCKDSPNKLSHIGDKS--CSSHSSS 1226
+ +H H GS + GS + G + SSH
Sbjct: 2220 HSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQH 2279
Query: 1227 NTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGS 1286
+ SS +SS GSG P G S+ G + ++ G H +GS
Sbjct: 2280 GSGSSQSSSYGQQ---GSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGR-HGSGS 2335
Query: 1287 ---RSLIHSRAEQWADAADVS-GPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSH 1342
H + W + G + Y HG S G ++ G S SS
Sbjct: 2336 GQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRS----GQSSRGERHGSSSGSSS 2391
Query: 1343 SSGSHHSGSPSA--HCSKSSGSLDSSKVYIVSHSSGQQVPGSMSKPYHRQGAVNKYVIGW 1400
S G H SGS + H SGS S H SG S S PY GW
Sbjct: 2392 SYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYS-PYGSGS-------GW 2443
Query: 1401 KKSEG 1405
S G
Sbjct: 2444 SSSRG 2448
Score = 31.6 bits (70), Expect = 7.0
Identities = 69/305 (22%), Positives = 89/305 (29%), Gaps = 57/305 (18%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSG--PWRPQVGYDGCQSPLLLEH------------QGSGPL 1161
G S S+QSS GSG P Q G QSP H GSG
Sbjct: 1103 GQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLG 1162
Query: 1162 ECDGAREREDTMEASRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCS 1221
E G E + + + HG S Y + + S + H S
Sbjct: 1163 ESSGFGHHESS--SGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE----RHGSSSGSS 1216
Query: 1222 SHSSSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPV 1281
SH + S SS + GSG G G S+ G + ++ GP
Sbjct: 1217 SHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGL--GHSSSHGQHGSGSGRSSSRGPY 1274
Query: 1282 HLAGSRSLI-----------------------------HSRAEQWADAADVSGPDDEPAK 1312
S + H + D G +
Sbjct: 1275 ESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSS 1334
Query: 1313 LYSVHGYASTISAGSAAEGS-MGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIV 1371
Y G S+ S+G G+ G H SGS HS S H S S S S +
Sbjct: 1335 SYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGR---- 1390
Query: 1372 SHSSG 1376
H SG
Sbjct: 1391 -HGSG 1394
Score = 31.2 bits (69), Expect = 9.1
Identities = 82/329 (24%), Positives = 106/329 (32%), Gaps = 75/329 (22%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
G S S SS+ GSG + Q +H + +E T ++
Sbjct: 1755 GQHESGSGHSSAYSQHGSGSGHFCSQG-----------QHGSTSGQSSTFDQEGSSTGQS 1803
Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235
S H + HG S SY + Q GS + SP++ H SS + S SS
Sbjct: 1804 SSHGQ---HGSGSSQSSSYGQ---QGSGSGQ-SPSRGRHGSGSGHSSSYGQHGSGSGWSS 1856
Query: 1236 NSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSRSLIHSRAE 1295
+S GSG + G + + +S S T + GSRS SR E
Sbjct: 1857 SSGRHGSGSG-----QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGE 1911
Query: 1296 QWADAADVS---------------------GPDDEPAKLYSVHGYASTISA-------GS 1327
Q ++ S G P+ HG S S+ GS
Sbjct: 1912 QHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGS 1971
Query: 1328 AAEGSMGDLSEISSHSSGSHH-------------SGSPSAHCS----KSSGSLDSSKVYI 1370
S G S HSSG H GS S H S S S SS
Sbjct: 1972 GWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQ 2031
Query: 1371 VSHSSGQQVP-------GSMSKPYHRQGA 1392
SSGQ S S Y RQG+
Sbjct: 2032 HGASSGQSSSHGQHGSGSSQSSGYGRQGS 2060
Score = 31.2 bits (69), Expect = 9.1
Identities = 67/250 (26%), Positives = 89/250 (35%), Gaps = 41/250 (16%)
Query: 1116 GTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEA 1175
G + S QSSS G GSG + GY QGSG + G +R
Sbjct: 2500 GQHGASSGQSSSH--GQHGSGSSQSS-GYG---------RQGSGSGQSPGHGQRGSGSRQ 2547
Query: 1176 SRHPETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSS 1235
S P HG GS + + + GS + H S S S S S + S
Sbjct: 2548 S--PSYGRHGS-----GSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHS 2600
Query: 1236 NSDDKHFG-SGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLAGSR-SLIHSR 1293
+ +H SG E G + G+S+ G H +GSR S H R
Sbjct: 2601 SGYGQHGSRSGQSSRGERHGSS--SGSSSHYG--------------QHGSGSRQSSGHGR 2644
Query: 1294 AEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGS----MGDLSEISSHSSGSHHS 1349
+ + G S HG + S S++ G +G S H SGS HS
Sbjct: 2645 QGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHS 2704
Query: 1350 GSPSAHCSKS 1359
+ S H S S
Sbjct: 2705 SAYSQHGSGS 2714
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 40.8 bits (94), Expect = 0.011
Identities = 77/327 (23%), Positives = 123/327 (37%), Gaps = 43/327 (13%)
Query: 971 VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSVTVKVVIIQPHDDGSP 1030
V +V+ G A +AGLR G RLV++ +V T+ Q+I L++ S + I P D+
Sbjct: 6 VKNVKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDIL 65
Query: 1031 RRGCSELCRIPMVE-YKLDSEGTPCEYKTPFRRNTTWHRVPTPALQPLSRASPIPGTPDR 1089
+ S+ + E Y ++ P + R T P + +RA+ +P
Sbjct: 66 QLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTY-----APPARASTRATMVPEPTSA 120
Query: 1090 LPCQQLLQQAQAAIPRSTSF----DRKLPDGTRSSPSNQS---SSSDPGPGGSGPWRPQV 1142
LP PRS + ++P R+ N S S P PG P +
Sbjct: 121 LPSD----------PRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAF----PHL 166
Query: 1143 GYDGCQSPLLLEHQGS----GPLECDGAREREDTMEASRHP-ETKWHGPPSKVLGSYKER 1197
+ ++P GS LEC A + + R E + + + ++R
Sbjct: 167 SSEP-RTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDR 225
Query: 1198 ----ALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDKHFGSGDLMDPELL 1253
A + C S + LS +G + S + LS T S + G G L+ P
Sbjct: 226 LEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATRS---AEALGPGALVSPRFE 282
Query: 1254 GLTYIKGASTDSGIDTAPCMPATILGP 1280
+ AS S T C + GP
Sbjct: 283 RCGW---ASQRSSARTPACPTRDLPGP 306
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 40.4 bits (93), Expect = 0.015
Identities = 40/160 (25%), Positives = 60/160 (37%), Gaps = 14/160 (8%)
Query: 1082 PIPGTPD----RLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSPSNQSSSSDPGPGGSGP 1137
P PG P P QQ A + +R+ + SS S+ SSSS S
Sbjct: 2497 PAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSS 2556
Query: 1138 WRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSYKER 1197
+G S P++ + A +R + + + PP K R
Sbjct: 2557 GSSSSDSEG----------SSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRR 2606
Query: 1198 ALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNS 1237
+ S S + S S SS SSS++ SS++SS+S
Sbjct: 2607 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2646
Score = 37.0 bits (84), Expect = 0.17
Identities = 45/177 (25%), Positives = 64/177 (36%), Gaps = 24/177 (13%)
Query: 1069 VPTPALQPLSRASPIPGTPDRLPC-----QQLLQQAQAAIPRSTSFDRKLPDGTRSSPSN 1123
VP P + P T + P Q ++ ++ S+S + SS S+
Sbjct: 2496 VPAPGVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSS 2555
Query: 1124 QSSSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQGSGPLECDGAREREDTMEASRHPETKW 1183
SSS G S P +P+V SP P + RE R PE
Sbjct: 2556 SGSSSSDSEGSSLPVQPEVALKRVPSPT--------PAPKEAVRE-------GRPPEPT- 2599
Query: 1184 HGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHSSSNTLSSNTSSNSDDK 1240
P+K + S S + S S SS SSS++ SS++SS S K
Sbjct: 2600 ---PAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAK 2653
Score = 36.2 bits (82), Expect = 0.28
Identities = 76/323 (23%), Positives = 110/323 (34%), Gaps = 66/323 (20%)
Query: 1063 NTTWHRVPTPALQPLS-RASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRSSP 1121
N T RVP A + +S R SP LL +A++ P S ++ SP
Sbjct: 2379 NLTSPRVPLSAYERVSGRTSP-----------PLLDRARSRTPPSAPSQSRMTSERAPSP 2427
Query: 1122 SNQS----SSSDPGPGGSGPWRPQVGYDGCQSPLLLEHQG--SGPLECDGAREREDTMEA 1175
S++ S S P P P QS L+ +G T A
Sbjct: 2428 SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSA 2487
Query: 1176 SRH-----------PETKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSHS 1224
H P + PP+ G+ + AL K+ + S S SS S
Sbjct: 2488 GDHNGMLSVPAPGVPHSDVGEPPAST-GAQQPSALAALQPAKERRSSSSSSSSSSSSSSS 2546
Query: 1225 SSNTLSSNTSSNSDDKHFGSGDLMDPELLGLTYIKGASTDSGIDTAPCMPATILGPVHLA 1284
SS++ SS++S +S GS + PE+ +P+ P
Sbjct: 2547 SSSSSSSSSSGSSSSDSEGSSLPVQPEV----------------ALKRVPSPTPAPKEA- 2589
Query: 1285 GSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYASTISAGSAAEGSMGDLSEISSHSS 1344
+ P+ PAK S+ S+ S++ S S SS SS
Sbjct: 2590 ---------------VREGRPPEPTPAK----RKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630
Query: 1345 GSHHSGSPSAHCSKSSGSLDSSK 1367
S S S S+ S SS S +K
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAK 2653
Score = 33.1 bits (74), Expect = 2.4
Identities = 35/138 (25%), Positives = 50/138 (36%), Gaps = 9/138 (6%)
Query: 1110 DRKLPDGTRSSPSNQSSSSDPGPGGSGPWRPQVGYDGCQSPL----LLEHQGSGPLECDG 1165
D+K TR SPS + SS+ P P P + + G PL L + + P E
Sbjct: 341 DKKEKSATRPSPSPERSSTGPEPPAPTPLLAE-RHGGSPQPLATTPLSQEPVNPPSEASP 399
Query: 1166 AREREDTMEASRHPE--TKWHGPPSKVLGSYKERALQKDGSCKDSPNKLSHIGDKSCSSH 1223
R+R + P+ + PPS A S K +P SH + SS
Sbjct: 400 TRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSH--REISSSP 457
Query: 1224 SSSNTLSSNTSSNSDDKH 1241
+S N + H
Sbjct: 458 TSKNRSHGRAKRDKSHSH 475
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 39.7 bits (91), Expect = 0.026
Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 6/72 (8%)
Query: 962 GFHVNFEG-----IVADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSV- 1015
GFH++ E + VEP A KAGL G RLVE+ V TH+Q++ +R ++
Sbjct: 25 GFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALN 84
Query: 1016 TVKVVIIQPHDD 1027
V+++++ P D
Sbjct: 85 AVRLLVVDPETD 96
>gi|8923040 CDKN2A interacting protein [Homo sapiens]
Length = 580
Score = 38.9 bits (89), Expect = 0.044
Identities = 65/242 (26%), Positives = 96/242 (39%), Gaps = 26/242 (10%)
Query: 1152 LLEHQGSGPLECDGAREREDTMEASRHPETKWHGPPSKVLGSY--KERALQKDGSCKDSP 1209
++E + S +E D A+ T AS E S +GS E S S
Sbjct: 145 VIEGKNSSAVEQDHAKTSAKTERASAQQENS-----STCIGSAIKSESGNSARSSGISSQ 199
Query: 1210 NKLSHIGDKSCSSHSSSNTLSSNTSSNS--------DDKHFGSGDLMDPELLGLTYIKGA 1261
N + GD+S SS SSS+ S T++ S DKH GS + +
Sbjct: 200 NSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKH-GSASFVSLLKSSVNSHMTQ 258
Query: 1262 STDSGIDTAPCMPATILGPVHLAGSRSLIHSRAEQWADAADVSGPDDEPAKLYSVHGYAS 1321
STDS + + + G S S S +E SG + L S +
Sbjct: 259 STDSRQQSGSPKKSALEG-----SSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSE 313
Query: 1322 TISAGSAAEGSMGDLSEISSHSSGSHHSGSPSAHCSKSSGSLDSSKVYIVSHSSGQQVPG 1381
T S+G ++ S + S SS + S SG+ S KSS S ++S +++ S QV
Sbjct: 314 TASSGLTSKTS-SEASVSSSVAKNSSSSGT-SLLTPKSSSSTNTS---LLTSKSTSQVAA 368
Query: 1382 SM 1383
S+
Sbjct: 369 SL 370
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 38.9 bits (89), Expect = 0.044
Identities = 58/199 (29%), Positives = 81/199 (40%), Gaps = 54/199 (27%)
Query: 968 EGI-VADVEPFGFAWKAG-LRQGSRLVEICKVAVATLTHEQMIDLLRT---SVTVKV--- 1019
EGI ++ V P G A + G LR G RL+E+ + ++ LTH + + LLR+ ++TV V
Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191
Query: 1020 --------------VIIQPHDDGSPRRGCSELCRIPMVEYKLDSEGTPCEYKTPFRRNTT 1065
VI P G R E I ++ +L EG E + P +
Sbjct: 1192 FEASTDAALEVSPGVIANPFAAGIGHRNSLE--SISSIDRELSPEGPGKEKELP-GQTLH 1248
Query: 1066 WHRVPTPA----LQPLSRASPIPGTPDRLPCQQLLQQAQAAIPRSTSFDRKLPDGTRS-- 1119
W T A LQPL +L +A AA+P + S R +P G
Sbjct: 1249 WGPEATEAAGRGLQPL----------------KLDYRALAAVPSAGSVQR-VPSGAAGGK 1291
Query: 1120 ------SPSNQSSSSDPGP 1132
SPS Q S P P
Sbjct: 1292 MAESPCSPSGQQPPSPPSP 1310
Score = 37.7 bits (86), Expect = 0.097
Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 18/105 (17%)
Query: 957 GLGQLGFHVNFEGI-VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMIDLLRTSV 1015
G G + + EGI ++ V G A +AG+R G +L+E+ VA+ H + ++ LR +
Sbjct: 745 GKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAG 804
Query: 1016 T-----------------VKVVIIQPHDDGSPRRGCSELCRIPMV 1043
T V + ++P DD SPR R+P++
Sbjct: 805 TAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLL 849
Score = 31.2 bits (69), Expect = 9.1
Identities = 24/78 (30%), Positives = 40/78 (51%), Gaps = 6/78 (7%)
Query: 963 FHVNFEGI-VADVEPFGFAWKAGLRQGSRLVEICKVAVATLTHEQMID-LLRTSVTVKVV 1020
F V G+ ++ V P G A ++GLR G R++ + V TH++ + LLR + + ++
Sbjct: 1029 FGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLL 1088
Query: 1021 IIQPHDDGSPRRGCSELC 1038
+ D P G ELC
Sbjct: 1089 V--RRDPAPP--GLRELC 1102
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,486,260
Number of Sequences: 37866
Number of extensions: 3506879
Number of successful extensions: 15550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 14879
Number of HSP's gapped (non-prelim): 688
length of query: 1722
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1606
effective length of database: 13,855,062
effective search space: 22251229572
effective search space used: 22251229572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.