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Search of human proteins with 169170558
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169170558 PREDICTED: RCC1-like G exchanging factor-like
[Homo sapiens]
(267 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 563 e-161
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 563 e-161
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 561 e-160
gi|7657152 hect domain and RLD 3 [Homo sapiens] 119 2e-27
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 105 5e-23
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 105 5e-23
gi|4557445 regulator of chromosome condensation and BTB domain c... 91 1e-18
gi|61563742 hect domain and RLD 6 [Homo sapiens] 87 1e-17
gi|110825982 hect domain and RLD 5 [Homo sapiens] 87 2e-17
gi|126032348 hect domain and RLD 2 [Homo sapiens] 86 3e-17
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 86 3e-17
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 84 2e-16
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 77 1e-14
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 77 1e-14
gi|6912330 deafness locus associated putative guanine nucleotide... 77 2e-14
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 70 1e-12
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 70 1e-12
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 65 5e-11
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 63 3e-10
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 58 8e-09
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 58 8e-09
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 58 8e-09
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 58 8e-09
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 58 8e-09
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 58 8e-09
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 58 1e-08
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 54 1e-07
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 54 1e-07
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 49 5e-06
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 48 1e-05
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 563 bits (1450), Expect = e-161
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
Query: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
Query: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 563 bits (1450), Expect = e-161
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
Query: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
Query: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 561 bits (1445), Expect = e-160
Identities = 266/267 (99%), Positives = 266/267 (99%)
Query: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317
Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377
Query: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Query: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464
Score = 34.7 bits (78), Expect = 0.089
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%)
Query: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189
K+ AACG G +L+ + VWG G L K L ++ P+
Sbjct: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
Query: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243
L P E +V ++ CG + LT++ +F G N G G +E++ + RV
Sbjct: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
Query: 244 -TMPGEPVDVACGVDHMVTL 262
G+ V VACG DH + L
Sbjct: 226 QDFDGQVVQVACGQDHSLFL 245
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 119 bits (299), Expect = 2e-27
Identities = 82/239 (34%), Positives = 117/239 (48%), Gaps = 16/239 (6%)
Query: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 91
D V +VACG +HS+FL + GEVY+CG GQ LGH + P ++G LA ++I V
Sbjct: 33 DRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQ--LGHEREGNKPEQIGA-LADQHIIHV 89
Query: 92 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
A LA+S G LF WG QL +T V VPR + + Q +CG C
Sbjct: 90 ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149
Query: 152 AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSR 208
L +G F WG +G LG G A P+ + +L G I ++++ G +
Sbjct: 150 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG-------IPLAQVAAGGAH 201
Query: 209 FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM--PGEPVDVACGVDHMVTLAKS 265
AL+ G +F WG N G LG+ +D+ P V + + V ++CG +H L KS
Sbjct: 202 SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKS 260
Score = 77.0 bits (188), Expect = 2e-14
Identities = 72/235 (30%), Positives = 110/235 (46%), Gaps = 17/235 (7%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRM-QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGW 59
G S GQ G E+ + V R+ Q + Q ++QV+CG H L L G+ ++ G
Sbjct: 109 GAGSDGQLGLMTTEDSV-----AVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 163
Query: 60 GADGQTGLG-HYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL 118
+ GQ GLG + +SP ++ L G+ + QVA G A+S G +FGWG + QL
Sbjct: 164 NSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQL 222
Query: 119 ASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESA 178
++D P + KV +CG AVL G VF +G G G+ + +S
Sbjct: 223 G-LSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH--DSM 279
Query: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSR-FAALTNKGELFVWGKNIRGCLGIG 232
E+ P + L +V++I CG A + + G ++ +G RG LG G
Sbjct: 280 NDEVNPRRVLELM----GSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330
Score = 49.7 bits (117), Expect = 3e-06
Identities = 38/137 (27%), Positives = 57/137 (41%), Gaps = 11/137 (8%)
Query: 130 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG 189
P+ F V++ ACGG L +G V+ G G+ + E PE I
Sbjct: 25 PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL--- 81
Query: 190 LTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP 249
+ + + CG S AL+++G+LF WG G LG+ ED R+
Sbjct: 82 -----ADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQ 136
Query: 250 ---VDVACGVDHMVTLA 263
+ V+CG H + LA
Sbjct: 137 QTILQVSCGNWHCLALA 153
Score = 45.8 bits (107), Expect = 4e-05
Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSL-FLTDKGEVYSCGWG 60
G S GQ G + +E+ RV ++ +V Q+ACG+ H+L F+ G +Y+ G G
Sbjct: 267 GAGSCGQLGHDSMNDEV--NPRRV--LELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCG 322
Query: 61 ADGQTGLGHYNITSSPTKLGG 81
A GQ G GH P+ + G
Sbjct: 323 ARGQLGTGHTCNVKCPSPVKG 343
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 105 bits (261), Expect = 5e-23
Identities = 85/270 (31%), Positives = 125/270 (46%), Gaps = 22/270 (8%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
GN S+GQ G ++ EI E R DF + +V V CG H++F+ D G VY+CG
Sbjct: 5 GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 60 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
GQ LGH P ++ L N++ V+ LA++ G ++ WG QL
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 176
V + VPR + ++ Q ACG L+ VF WG YG LG G + +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177
Query: 177 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLED 236
P+++ +L G+ P +QV+ G + LT G +F WG+N G LG+ D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229
Query: 237 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 264
+Y P + + V + CG DH L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259
Score = 89.4 bits (220), Expect = 3e-18
Identities = 81/271 (29%), Positives = 117/271 (43%), Gaps = 38/271 (14%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
G N GQ G + + ++ D Q +V V+CG+ H+L L DKG+VY+ G
Sbjct: 59 GCNDLGQLGHE-------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLD 111
Query: 61 ADGQTGL-GHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
+DGQ GL G P + L+ + ++QVA LA+S +F WG ++Y QL
Sbjct: 112 SDGQLGLVGSEECIRVPRNI-KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKG----- 171
TD + P+ L Q A GG VL G +F WG +G LG
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 172 --PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCL 229
PNL++S + ++ I CG AALT +G +F +G G L
Sbjct: 231 YVPNLLKSLRSQ----------------KIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 230 GIGRLEDQYFPWRV--TMPGEPVDVACGVDH 258
G + P +V M ++ACG H
Sbjct: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQH 305
Score = 87.4 bits (215), Expect = 1e-17
Identities = 78/254 (30%), Positives = 110/254 (43%), Gaps = 11/254 (4%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G +S GQ G V E + + D Q+VQVACG HSL L+ EV+ G
Sbjct: 109 GLDSDGQLGL-VGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSKASEVFCWGQNK 165
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
GQ GLG + +L L G+ +QVA G ++ G +FGWG +++ QL +
Sbjct: 166 YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GL 224
Query: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPE 181
D VP L K+ CG A L EG VF +G G G G S E
Sbjct: 225 NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHE 282
Query: 182 MIPPTLFGLTEFNPEIQVSRIRCGLSRFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
+ P +F L V+ I CG +A + + G ++ +G G LG G ++ P
Sbjct: 283 INPRKVFELM----GSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
Query: 241 WRVTMPGEPVDVAC 254
+ V P + C
Sbjct: 339 FTVKGNWYPYNGQC 352
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 105 bits (261), Expect = 5e-23
Identities = 85/270 (31%), Positives = 125/270 (46%), Gaps = 22/270 (8%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
GN S+GQ G ++ EI E R DF + +V V CG H++F+ D G VY+CG
Sbjct: 5 GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 60 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
GQ LGH P ++ L N++ V+ LA++ G ++ WG QL
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 176
V + VPR + ++ Q ACG L+ VF WG YG LG G + +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177
Query: 177 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLED 236
P+++ +L G+ P +QV+ G + LT G +F WG+N G LG+ D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229
Query: 237 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 264
+Y P + + V + CG DH L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259
Score = 89.4 bits (220), Expect = 3e-18
Identities = 81/271 (29%), Positives = 117/271 (43%), Gaps = 38/271 (14%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
G N GQ G + + ++ D Q +V V+CG+ H+L L DKG+VY+ G
Sbjct: 59 GCNDLGQLGHE-------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLD 111
Query: 61 ADGQTGL-GHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
+DGQ GL G P + L+ + ++QVA LA+S +F WG ++Y QL
Sbjct: 112 SDGQLGLVGSEECIRVPRNI-KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKG----- 171
TD + P+ L Q A GG VL G +F WG +G LG
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230
Query: 172 --PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCL 229
PNL++S + ++ I CG AALT +G +F +G G L
Sbjct: 231 YVPNLLKSLRSQ----------------KIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274
Query: 230 GIGRLEDQYFPWRV--TMPGEPVDVACGVDH 258
G + P +V M ++ACG H
Sbjct: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQH 305
Score = 87.4 bits (215), Expect = 1e-17
Identities = 78/254 (30%), Positives = 110/254 (43%), Gaps = 11/254 (4%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G +S GQ G V E + + D Q+VQVACG HSL L+ EV+ G
Sbjct: 109 GLDSDGQLGL-VGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSKASEVFCWGQNK 165
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
GQ GLG + +L L G+ +QVA G ++ G +FGWG +++ QL +
Sbjct: 166 YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GL 224
Query: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPE 181
D VP L K+ CG A L EG VF +G G G G S E
Sbjct: 225 NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHE 282
Query: 182 MIPPTLFGLTEFNPEIQVSRIRCGLSRFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
+ P +F L V+ I CG +A + + G ++ +G G LG G ++ P
Sbjct: 283 INPRKVFELM----GSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338
Query: 241 WRVTMPGEPVDVAC 254
+ V P + C
Sbjct: 339 FTVKGNWYPYNGQC 352
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 90.5 bits (223), Expect = 1e-18
Identities = 74/253 (29%), Positives = 117/253 (46%), Gaps = 25/253 (9%)
Query: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVAC----GQDHSLFLTDKGEVYS 56
+G N G G V++ I R+ +G+ ++AC H + T +GEV++
Sbjct: 70 LGTNCCGCLGLGDVQSTI-----EPRRLDSLNGK--KIACLSYGSGPHIVLATTEGEVFT 122
Query: 57 CGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
G A Q G G N P + +L+ VI+VA L +++DG +F WG +
Sbjct: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182
Query: 117 QLASVTDSTQVNVPR----CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGP 172
Q+ S + Q +PR CL V + ACG C + G V+VWGY G G
Sbjct: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTI---ACGQMCCMAVVDTGEVYVWGYN--GNGQ 236
Query: 173 NLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIG 232
+ ++ + P + L I+V R+ CG + LT++G+++ WG N G LG G
Sbjct: 237 LGLGNSGNQPTPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292
Query: 233 RLEDQYFPWRVTM 245
+Q +P VT+
Sbjct: 293 NKSNQSYPTPVTV 305
Score = 89.0 bits (219), Expect = 4e-18
Identities = 68/226 (30%), Positives = 101/226 (44%), Gaps = 17/226 (7%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWG 60
G+N+Y Q G + + H + QV++VACG HSL LT GEV++ G+
Sbjct: 124 GHNAYSQLGNGTTNHGLVP----CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 179
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
GQ G G P ++ G L V+ +A CC+AV G ++ WG + QL
Sbjct: 180 NSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGL 239
Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVES 177
Q R G+ +V++ ACG VL EG V+ WG YG LG G N
Sbjct: 240 GNSGNQPTPCRVAALQGI-RVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQ 297
Query: 178 AVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
+ P + E + I+++ AA T G +++WG+
Sbjct: 298 SYPTPV------TVEKDRIIEIAACH-STHTSAAKTQGGHVYMWGQ 336
Score = 83.2 bits (204), Expect = 2e-16
Identities = 77/243 (31%), Positives = 109/243 (44%), Gaps = 27/243 (11%)
Query: 34 QVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVI 89
Q+++ AC + L+ T E++ G G GLG T P +L D I
Sbjct: 43 QLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL--DSLNGKKI 100
Query: 90 QVATYGD--CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQA 144
+YG + + +G +F WG++ Y QL + T T + C H S +V +
Sbjct: 101 ACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGT--TNHGLVPC-HISTNLSNKQVIEV 157
Query: 145 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201
ACG VL +G VF WGY G +G G S V + IP + G + V
Sbjct: 158 ACGSYHSLVLTSDGEVFAWGYNNSGQVGSG-----STVNQPIPRRVTGCLQ---NKVVVT 209
Query: 202 IRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHM 259
I CG A+ + GE++VWG N G LG+G +Q P RV + G V VACG H
Sbjct: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269
Query: 260 VTL 262
+ L
Sbjct: 270 LVL 272
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 87.4 bits (215), Expect = 1e-17
Identities = 75/260 (28%), Positives = 117/260 (45%), Gaps = 12/260 (4%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ-VACGQDHSLFLTDKGEVYSCGWG 60
G+NS GQ GR+ + E +Q + +V V+CG++HSL + KG V++ G G
Sbjct: 48 GDNSRGQLGRRGAQRGELPEP-----IQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAG 102
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
++GQ G+G + S K L + +IQV+ LA+S D +F WG + + QL
Sbjct: 103 SEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL 162
Query: 121 VTD-STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAV 179
+ +Q + R G+ + Q A GG L+ G F WG G+ +
Sbjct: 163 GKEFPSQASPQRVRSLEGI-PLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVP 221
Query: 180 PEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF 239
+ P G + + V I CG + A LT G++F +G N G LG ++
Sbjct: 222 VQSNKPLSVGALK---NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRG 278
Query: 240 PWRV-TMPGEPVDVACGVDH 258
P V + G + CG H
Sbjct: 279 PQLVERIDGLVSQIDCGSYH 298
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 87.0 bits (214), Expect = 2e-17
Identities = 65/231 (28%), Positives = 112/231 (48%), Gaps = 10/231 (4%)
Query: 12 KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN 71
K E + YS H + +++Q+ CG HSL L+ GE+++ G GQ G+G
Sbjct: 117 KPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKF 176
Query: 72 ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 131
+++ ++ LAGV + Q++ +A+S G ++ WG +E QL + + + P
Sbjct: 177 PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL-GLGHTESKDDPS 235
Query: 132 CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGL 190
+ KV ACGG+ A+L +G +F +G G G+ G N ++ + + L G
Sbjct: 236 LIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG- 294
Query: 191 TEFNPEIQVSRIRCG-LSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
+V++I CG A +++ G++F +G G LG G DQ P
Sbjct: 295 ------YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 86.3 bits (212), Expect = 3e-17
Identities = 72/240 (30%), Positives = 112/240 (46%), Gaps = 19/240 (7%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQVA G +T +G+VY+CG +G+ GLG + T + L+ V +VA +
Sbjct: 2994 VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVH 3053
Query: 95 --GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
G A++ DG +F WG + +L + + PR + ++R ACG + A
Sbjct: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFS-RMNCDKPRLIEALKTKRIRDIACGSSHSA 3112
Query: 153 VLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--S 207
L G ++ WG YG LG G N + P+M+ L +V ++ CG +
Sbjct: 3113 ALTSSGELYTWGLGEYGRLGHGDNTTQ-LKPKMVKVLL--------GHRVIQVACGSRDA 3163
Query: 208 RFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPV-DVACGVDHMVTLAKS 265
+ ALT++G +F WG G LG G E P + + G+ V + CG + L KS
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223
Score = 82.4 bits (202), Expect = 4e-16
Identities = 73/242 (30%), Positives = 107/242 (44%), Gaps = 22/242 (9%)
Query: 35 VVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP---TKLGGDLAGVNVI 89
+V++A D H L L GEVYS G G G+ G G P + G AG +V+
Sbjct: 495 IVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVV 554
Query: 90 QVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGT 149
+A A++A+G L+ WG Y +L + + G+ KV ACG
Sbjct: 555 HIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSG 613
Query: 150 GCAVL--NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 204
L G V+ WG YG LG+G + P++I E ++ V ++RC
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLI--------EKLQDLDVVKVRC 664
Query: 205 GLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMVTL 262
G ALT G+++ WGK LG G E +P + + G+ V DVA G H + L
Sbjct: 665 GSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLAL 724
Query: 263 AK 264
+
Sbjct: 725 TE 726
Score = 79.3 bits (194), Expect = 3e-15
Identities = 72/234 (30%), Positives = 104/234 (44%), Gaps = 18/234 (7%)
Query: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA- 92
++ +ACG HS LT GE+Y+ G G G+ G G N T K+ L G VIQVA
Sbjct: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVAC 3158
Query: 93 -TYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
+ LA++ +G +F WG+ ++ +L S N+P+ + V Q CG
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFS 3217
Query: 152 AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSR 208
L G V+ WG Y LG G S V P + GL ++ + G
Sbjct: 3218 LALTKSGVVWTWGKGDYFRLGHG-----SDVHVRKPQVVEGLR----GKKIVHVAVGALH 3268
Query: 209 FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPVD-VACGVDHMV 260
A+T+ G+++ WG N G G G P V + G+ + VACG H V
Sbjct: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322
Score = 76.3 bits (186), Expect = 3e-14
Identities = 72/243 (29%), Positives = 113/243 (46%), Gaps = 34/243 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
V Q+AC + L L+ G VY+ + +D T +P + G LA N++++A +
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSD----------TLAPQLVQG-LASRNIVKIAAH 501
Query: 95 GD--CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH-FSG--VGK-VRQAACGG 148
D LA++A G ++ WG + +L D+ + P+ + FSG GK V ACG
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH-GDTVPLEEPKVISAFSGKQAGKHVVHIACGS 560
Query: 149 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 205
T A + EG ++ WG YG LG G S+ E IP + GL ++V + CG
Sbjct: 561 TYSAAITAEGELYTWGRGNYGRLGHG-----SSEDEAIPMLVAGL----KGLKVIDVACG 611
Query: 206 L--SRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--TMPGEPVDVACGVDHMVT 261
++ A+T G+++ WG G LG G + P + + V V CG +
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIA 671
Query: 262 LAK 264
L K
Sbjct: 672 LTK 674
Score = 75.9 bits (185), Expect = 3e-14
Identities = 64/202 (31%), Positives = 89/202 (44%), Gaps = 16/202 (7%)
Query: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
V V G H L L+ +GEVYS G DG+ G G+ + P + L G+ V+ VA G
Sbjct: 4042 VAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES-LRGIEVVDVAAGG 4100
Query: 96 DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL- 154
V+A G L+ WG Y +L +DS P+ + +V ACG L
Sbjct: 4101 AHSACVTAAGDLYTWGKGRYGRLGH-SDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159
Query: 155 -NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
+ V+ WG YG LG+G + + M +L GL V ++ CG
Sbjct: 4160 LTDDDTVWSWGDGDYGKLGRGGS--DGCKVPMKIDSLTGLG-------VVKVECGSQFSV 4210
Query: 211 ALTNKGELFVWGKNIRGCLGIG 232
ALT G ++ WGK LG G
Sbjct: 4211 ALTKSGAVYTWGKGDYHRLGHG 4232
Score = 74.7 bits (182), Expect = 8e-14
Identities = 65/235 (27%), Positives = 109/235 (46%), Gaps = 12/235 (5%)
Query: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG-DLAGVNVIQVATY 94
VQ+ G+ +T G++Y+ G+GA G+ G+G S+PT L + + V +
Sbjct: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSG 4047
Query: 95 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
G CLA+S++G ++ WG +E +L + + + PR + +V A GG A +
Sbjct: 4048 GKHCLALSSEGEVYSWGEAEDGKLGH-GNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106
Query: 155 NGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--SRFAAL 212
G ++ WG G G+ L S + + P L + + +V I CG ++ L
Sbjct: 4107 TAAGDLYTWGKGRYGR---LGHSDSEDQLKPKLVEALQGH---RVVDIACGSGDAQTLCL 4160
Query: 213 TNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPG-EPVDVACGVDHMVTLAKS 265
T+ ++ WG G LG G + P ++ ++ G V V CG V L KS
Sbjct: 4161 TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKS 4215
Score = 67.4 bits (163), Expect = 1e-11
Identities = 59/192 (30%), Positives = 87/192 (45%), Gaps = 10/192 (5%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT- 93
VV +ACG +S +T +GE+Y+ G G G+ G G + P + G L G+ VI VA
Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG-LKGLKVIDVACG 611
Query: 94 YGDC-CLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
GD LAV+ +G ++ WG+ +Y +L S P+ + V + CG
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGR-GGSDGCKTPKLIEKLQDLDVVKVRCGSQFSI 670
Query: 153 VLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAAL 212
L +G V+ WG G + + E V P L GL +V + G + AL
Sbjct: 671 ALTKDGQVYSWGKGDNQRLGHGTEEHV--RYPKLLEGLQGK----KVIDVAAGSTHCLAL 724
Query: 213 TNKGELFVWGKN 224
T E+ WG N
Sbjct: 725 TEDSEVHSWGSN 736
Score = 65.9 bits (159), Expect = 4e-11
Identities = 64/214 (29%), Positives = 92/214 (42%), Gaps = 19/214 (8%)
Query: 59 WGADGQTGLGHYNITSSPTKLGG---DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 115
WG + + LG + S K+ L+ +NV+QVA AV+ +G ++ G +
Sbjct: 2964 WGLNDKDQLG--GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATN 3021
Query: 116 LQLASVTDSTQVNVPRCLHFSGVGKVRQAAC--GGTGCAVLNGEGHVFVWGYGILGKGPN 173
+L S V +PR + V++ A GG L +G VF WG G GK +
Sbjct: 3022 GRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGH 3081
Query: 174 L--VESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGI 231
+ P +I E ++ I CG S AALT+ GEL+ WG G LG
Sbjct: 3082 FSRMNCDKPRLI--------EALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH 3133
Query: 232 GRLEDQYFP--WRVTMPGEPVDVACGVDHMVTLA 263
G Q P +V + + VACG TLA
Sbjct: 3134 GDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLA 3167
Score = 60.5 bits (145), Expect = 2e-09
Identities = 41/133 (30%), Positives = 65/133 (48%), Gaps = 4/133 (3%)
Query: 34 QVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 91
+V+ VACG +L +T+ G+V+S G G G+ G G + +P KL L ++V++V
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTP-KLIEKLQDLDVVKV 662
Query: 92 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
+A++ DG ++ WG + +L T+ V P+ L KV A G T C
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE-HVRYPKLLEGLQGKKVIDVAAGSTHC 721
Query: 152 AVLNGEGHVFVWG 164
L + V WG
Sbjct: 722 LALTEDSEVHSWG 734
Score = 59.3 bits (142), Expect = 3e-09
Identities = 40/116 (34%), Positives = 57/116 (49%), Gaps = 5/116 (4%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G+ YG+ GR + + ++QD D VV+V CG S+ LT G+VYS G G
Sbjct: 630 GDGDYGKLGRGGSDG--CKTPKLIEKLQDLD--VVKVRCGSQFSIALTKDGQVYSWGKGD 685
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQ 117
+ + G G P L G L G VI VA CLA++ D + WG+++ Q
Sbjct: 686 NQRLGHGTEEHVRYPKLLEG-LQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Score = 56.2 bits (134), Expect = 3e-08
Identities = 38/113 (33%), Positives = 57/113 (50%), Gaps = 2/113 (1%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VV+V CG S+ LT G VY+ G G + G G + P ++ G L G VI +AT
Sbjct: 4199 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG-LQGKKVIAIATG 4257
Query: 95 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 147
C+ + DG ++ WG+++ QL T + + PR + KV + ACG
Sbjct: 4258 SLHCVCCTEDGEVYTWGDNDEGQLGDGT-TNAIQRPRLVAALQGKKVNRVACG 4309
Score = 45.4 bits (106), Expect = 5e-05
Identities = 59/226 (26%), Positives = 81/226 (35%), Gaps = 69/226 (30%)
Query: 96 DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR-C---------------------- 132
D L+ G ++GWG++ QL + + +V VP C
Sbjct: 3943 DWTLSAGGSGTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
Query: 133 ----LHFSGVGKVRQAACGGT---------------------------GCAVLNGEGHVF 161
L+ +G G + GGT C L+ EG V+
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
Query: 162 VWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGEL 218
WG G LG G N P +I E I+V + G + A +T G+L
Sbjct: 4062 SWGEAEDGKLGHG-NRSPCDRPRVI--------ESLRGIEVVDVAAGGAHSACVTAAGDL 4112
Query: 219 FVWGKNIRGCLGIGRLEDQYFPWRV-TMPG-EPVDVACGVDHMVTL 262
+ WGK G LG EDQ P V + G VD+ACG TL
Sbjct: 4113 YTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTL 4158
Score = 36.6 bits (83), Expect = 0.024
Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 4/76 (5%)
Query: 20 SESH--RVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 76
S+ H R ++Q G+ V+ +A G H + T+ GEVY+ G +GQ G G N P
Sbjct: 4233 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP 4292
Query: 77 TKLGGDLAGVNVIQVA 92
+L L G V +VA
Sbjct: 4293 -RLVAALQGKKVNRVA 4307
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 85.9 bits (211), Expect = 3e-17
Identities = 66/213 (30%), Positives = 99/213 (46%), Gaps = 18/213 (8%)
Query: 44 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 103
H L T+ G VY+ G Q G G N +P ++ +L V++VA +A++A
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 104 DGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 160
DG +F WG + Q+ S + + Q V CLH + +V ACG T + G V
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGIACGQTSSMAVLDNGEV 202
Query: 161 FVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGE 217
+ WGY G LG G N ++ P + L + V++I CG + ALT++G
Sbjct: 203 YGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQIVCGYAHTLALTDEGL 253
Query: 218 LFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 250
L+ WG N G LG G + P + + E V
Sbjct: 254 LYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286
Score = 77.0 bits (188), Expect = 2e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 15/224 (6%)
Query: 45 SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA-TYGDCCLAVSA 103
+L++TD EV+ G G G T P KL G L G + ++ G L +
Sbjct: 34 ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG-LCGKKIKSLSYGSGPHVLLSTE 92
Query: 104 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 163
DG ++ WG++ Y QL + T + + + + +V + ACG L +G VF W
Sbjct: 93 DGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW 152
Query: 164 GY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFV 220
GY G +G G + PT +T +V I CG + A+ + GE++
Sbjct: 153 GYNNCGQVGSGSTANQ--------PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
Query: 221 WGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDHMVTL 262
WG N G LG+G +Q P RV + CG H + L
Sbjct: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248
Score = 73.2 bits (178), Expect = 2e-13
Identities = 64/225 (28%), Positives = 95/225 (42%), Gaps = 15/225 (6%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G+N Y Q G I + + QVV+VACG HS+ L GEV++ G+
Sbjct: 100 GHNGYSQLGNGTTNQGIAPVQVCTNLLIK---QVVEVACGSHHSMALAADGEVFAWGYNN 156
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
GQ G G +P K+ L V+ +A +AV +G ++GWG + QL
Sbjct: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
Query: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESA 178
+ Q+ R V V Q CG L EG ++ WG YG LG G N
Sbjct: 217 NNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG-NKNNLL 274
Query: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
P I + E ++++ + AA T G +++WG+
Sbjct: 275 SPAHI------MVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 83.6 bits (205), Expect = 2e-16
Identities = 69/250 (27%), Positives = 118/250 (47%), Gaps = 25/250 (10%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
G+ YG+ G + + R +++ G+ VVQ++CG HS +T G++++ G G
Sbjct: 4107 GDGDYGKLGHGNSDRQ-----RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG 4161
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGL-FGWGNSEYLQLA 119
G+ GLG+ + P ++ L G + QVA + LAVSADG + + +G+ +Y +L
Sbjct: 4162 DYGRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG 4220
Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGIL-----GKGPNL 174
+ + + + G+G +++ ACG L +GHV+ +G L G+ N
Sbjct: 4221 LGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNH 4279
Query: 175 VESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRL 234
P+ IP L G+ + + G AL + G+++ WG N G LG+G
Sbjct: 4280 NR---PQQIP-VLAGVI-------IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHT 4328
Query: 235 EDQYFPWRVT 244
P VT
Sbjct: 4329 NHVREPTLVT 4338
Score = 71.2 bits (173), Expect = 9e-13
Identities = 66/240 (27%), Positives = 104/240 (43%), Gaps = 23/240 (9%)
Query: 2 GNNSYGQCGRKVVENE-----IYSESHRVHRMQDFDGQVVQVACGQD-HSLFLTDKGEVY 55
G SYG+ G N+ + E HR + V + G D H+L T +GEV+
Sbjct: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKK-------VSSSKGSDGHTLAFTTEGEVF 480
Query: 56 SCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 115
S G G G+ G G+ + P + G L G V+ V+ AV+ DG L+ WG ++
Sbjct: 481 SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540
Query: 116 LQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLV 175
+L DS N+P + + V + +CG + L+ +G VW +G G L
Sbjct: 541 GRLGH-GDSNSRNIPTLV--KDISNVGEVSCGSSHTIALSKDGRT-VWSFG-GGDNGKLG 595
Query: 176 ESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLE 235
+ P + E + + ++ G ALT+ G+++ WG CLG G E
Sbjct: 596 HGDTNRVYKPKVI---EALQGMFIRKVCAGSQSSLALTSTGQVYAWG--CGACLGCGSSE 650
Score = 65.5 bits (158), Expect = 5e-11
Identities = 59/202 (29%), Positives = 92/202 (45%), Gaps = 18/202 (8%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VV V+ G HS +T+ GE+Y+ G G G+ G G N + PT L D++ NV +V+
Sbjct: 513 VVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPT-LVKDIS--NVGEVSCG 569
Query: 95 GDCCLAVSADGGL---FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
+A+S DG FG G++ L D+ +V P+ + +R+ G
Sbjct: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHG---DTNRVYKPKVIEALQGMFIRKVCAGSQSS 626
Query: 152 AVLNGEGHVFVWGYGI-LGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
L G V+ WG G LG G + + P++I E ++ + G S
Sbjct: 627 LALTSTGQVYAWGCGACLGCGSSEATALRPKLI--------EELAATRIVDVSIGDSHCL 678
Query: 211 ALTNKGELFVWGKNIRGCLGIG 232
AL++ E++ WG N G G G
Sbjct: 679 ALSHDNEVYAWGNNSMGQCGQG 700
Score = 64.3 bits (155), Expect = 1e-10
Identities = 73/267 (27%), Positives = 107/267 (40%), Gaps = 38/267 (14%)
Query: 13 VVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNI 72
V E+E+ + D Q++ A + L K +VY G G GQ N+
Sbjct: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNV 4017
Query: 73 TSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG----------GLFGWGNSEYLQLASVT 122
A QV +C + A+G G G GNS+ L + +V
Sbjct: 4018 MVPAAAPSFSQAQ----QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073
Query: 123 DSTQVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESA 178
+ Q V L S CG G ++ L G VF WG YG LG G N
Sbjct: 4074 SALQGFVVTQLVTS---------CGSDGHSMALTESGEVFSWGDGDYGKLGHG-NSDRQR 4123
Query: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQY 238
P I E +V ++ CG A +T+ G+LF +G G LG+G ++
Sbjct: 4124 RPRQI--------EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175
Query: 239 FPWRVT-MPGEPV-DVACGVDHMVTLA 263
P RVT + G + VACG++H + ++
Sbjct: 4176 LPERVTALEGYQIGQVACGLNHTLAVS 4202
Score = 63.5 bits (153), Expect = 2e-10
Identities = 62/218 (28%), Positives = 84/218 (38%), Gaps = 18/218 (8%)
Query: 53 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 112
EVY G + Q G P KL + I+ Y C +S DG + G
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQP-KLAPSFSDAQTIEAGQY--CTFVISTDGSVRACGK 429
Query: 113 SEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 166
Y +L + DS + + L F + KV + EG VF WG YG
Sbjct: 430 GSYGRLG-LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488
Query: 167 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIR 226
LG G N P++I L G V + G AA+T GEL+ WG+
Sbjct: 489 KLGHG-NSSTQKYPKLIQGPLQGKV-------VVCVSAGYRHSAAVTEDGELYTWGEGDF 540
Query: 227 GCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAK 264
G LG G + P V +V+CG H + L+K
Sbjct: 541 GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSK 578
Score = 56.6 bits (135), Expect = 2e-08
Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 21/216 (9%)
Query: 32 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD-LAGVNVIQ 90
D Q ++ GQ + ++ G V +CG G+ G+ GLG N S+ KL + + +
Sbjct: 404 DAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVS 461
Query: 91 VATYGD-CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGG- 148
+ D LA + +G +F WG+ +Y +L STQ P+ + GKV G
Sbjct: 462 SSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQ-KYPKLIQGPLQGKVVVCVSAGY 520
Query: 149 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 205
A + +G ++ WG +G LG G + + +P ++ V + CG
Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGHGDSNSRN-IPTLVKDI----------SNVGEVSCG 569
Query: 206 LSRFAALTNKGE-LFVWGKNIRGCLGIGRLEDQYFP 240
S AL+ G ++ +G G LG G Y P
Sbjct: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKP 605
Score = 53.9 bits (128), Expect = 1e-07
Identities = 32/117 (27%), Positives = 56/117 (47%), Gaps = 6/117 (5%)
Query: 19 YSESHRVHR---MQDFDGQVVQVAC-GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 74
+ +++RV++ ++ G ++ C G SL LT G+VY+ WG G G T+
Sbjct: 596 HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYA--WGCGACLGCGSSEATA 653
Query: 75 SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 131
KL +LA ++ V+ CLA+S D ++ WGN+ Q + + P+
Sbjct: 654 LRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPK 710
Score = 48.9 bits (115), Expect = 5e-06
Identities = 27/63 (42%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
+ VA G +H+L L G+VY+ G ++GQ GLGH N PT + G L G NV Q++
Sbjct: 4293 IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG-LQGKNVRQISA- 4350
Query: 95 GDC 97
G C
Sbjct: 4351 GRC 4353
Score = 33.1 bits (74), Expect = 0.26
Identities = 21/70 (30%), Positives = 34/70 (48%)
Query: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 93
++V V+ G H L L+ EVY+ G + GQ G G+ + K L G+ + Q++
Sbjct: 666 RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISA 725
Query: 94 YGDCCLAVSA 103
LA +A
Sbjct: 726 GTSHSLAWTA 735
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 77.4 bits (189), Expect = 1e-14
Identities = 69/240 (28%), Positives = 108/240 (45%), Gaps = 22/240 (9%)
Query: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV--KALKPEKVKLAACG 95
Query: 96 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
VS +GG G N L L + +V F+ K++Q + G A
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153
Query: 153 VLNGEGHVFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
L +G +F+WG G+ N+ VP+ + T P VS I CG A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203
Query: 211 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 267
+T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
Score = 65.5 bits (158), Expect = 5e-11
Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 72/320 (22%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G+N++GQ G + S+ V ++ +V ACG++H+L T+ G VY+ G
Sbjct: 60 GSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAACGRNHTLVSTEGGNVYATGGNN 115
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL--- 118
+GQ GLG ++ + + + Q++ + A++ DG LF WG++ Q+
Sbjct: 116 EGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLK 175
Query: 119 --ASVTDSTQVNVPRCLHFSGVG------------------------------------- 139
++V QV + + + + G
Sbjct: 176 NVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTP 235
Query: 140 --------KVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLF 188
KV Q ACGG VL E V+ +G +G LG G L E++ P++I
Sbjct: 236 QLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVI----- 289
Query: 189 GLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE 248
E + +S I CG + A +T+ G ++ +G G LG+G LE+ + T+
Sbjct: 290 ---ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG-LENFTNHFIPTLCSN 345
Query: 249 PVD-----VACGVDHMVTLA 263
+ VACG HMV A
Sbjct: 346 FLRFIVKLVACGGCHMVVFA 365
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 77.4 bits (189), Expect = 1e-14
Identities = 69/240 (28%), Positives = 108/240 (45%), Gaps = 22/240 (9%)
Query: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV--KALKPEKVKLAACG 95
Query: 96 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
VS +GG G N L L + +V F+ K++Q + G A
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153
Query: 153 VLNGEGHVFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
L +G +F+WG G+ N+ VP+ + T P VS I CG A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203
Query: 211 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 267
+T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
Score = 65.5 bits (158), Expect = 5e-11
Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 72/320 (22%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G+N++GQ G + S+ V ++ +V ACG++H+L T+ G VY+ G
Sbjct: 60 GSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAACGRNHTLVSTEGGNVYATGGNN 115
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL--- 118
+GQ GLG ++ + + + Q++ + A++ DG LF WG++ Q+
Sbjct: 116 EGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLK 175
Query: 119 --ASVTDSTQVNVPRCLHFSGVG------------------------------------- 139
++V QV + + + + G
Sbjct: 176 NVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTP 235
Query: 140 --------KVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLF 188
KV Q ACGG VL E V+ +G +G LG G L E++ P++I
Sbjct: 236 QLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVI----- 289
Query: 189 GLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE 248
E + +S I CG + A +T+ G ++ +G G LG+G LE+ + T+
Sbjct: 290 ---ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG-LENFTNHFIPTLCSN 345
Query: 249 PVD-----VACGVDHMVTLA 263
+ VACG HMV A
Sbjct: 346 FLRFIVKLVACGGCHMVVFA 365
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 76.6 bits (187), Expect = 2e-14
Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 22/237 (9%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
G NSYGQ G E+ + + ++ DF V ++ G HS +TD G+++ CG
Sbjct: 21 GANSYGQLGLGHKEDVLLPQ-----QLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
Query: 60 GADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQ 117
DGQ GLGH +P K L G + QVA D + ++ +G + G++ + Q
Sbjct: 76 NKDGQLGLGHTEDIPYFTPCK---SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQ 132
Query: 118 LASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVES 177
L + VP+ + KV A G G VF WG G+ G L
Sbjct: 133 LGVPHGPRRCVVPQAIELH-KEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRL--- 188
Query: 178 AVPEMIPPTLFGLTEFN--PEIQVSRIRC---GLSRFAALTNKGELFVWGKNIRGCL 229
P P F E + ++ S+ C G A+LT+ GE++VWG N G L
Sbjct: 189 -CPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL 244
Score = 64.3 bits (155), Expect = 1e-10
Identities = 73/265 (27%), Positives = 107/265 (40%), Gaps = 48/265 (18%)
Query: 31 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 90
F + QVACG D ++ LT+ G+V SCG + GQ G+ H +L V+
Sbjct: 99 FGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVC 157
Query: 91 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVR-------Q 143
+A +A +A G +F WG LAS L F+ R +
Sbjct: 158 IAAGLRHAVAATASGIVFQWGTG----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSK 213
Query: 144 AAC---GGTGCAVLNGEGHVFVWGYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEI 197
A C G A L G V+VWG G+ N E+A VP+ I F
Sbjct: 214 AMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCF------QNE 265
Query: 198 QVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-------------- 243
+V+ I G + A T G++F WG+ G L GR + Y W++
Sbjct: 266 KVTAIWSGWTHLVAQTETGKMFTWGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPN 323
Query: 244 TMPGEP------VDVACGVDHMVTL 262
+MP P +V+CG +H + +
Sbjct: 324 SMPSSPHCLTGATEVSCGSEHNLAI 348
Score = 46.2 bits (108), Expect = 3e-05
Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 160 VFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
+F WG YG LG G + + +P+ L +F V RI G A +T+ G
Sbjct: 17 LFAWGANSYGQLGLG-HKEDVLLPQQ-------LNDFCKPRSVRRITGGGGHSAVVTDGG 68
Query: 217 ELFVWGKNIRGCLGIGRLED-QYFPWRVTMPGEPV-DVACGVDHMVTLAKS 265
+LFV G N G LG+G ED YF ++ G P+ VACG D + L ++
Sbjct: 69 DLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 70.5 bits (171), Expect = 1e-12
Identities = 68/249 (27%), Positives = 110/249 (44%), Gaps = 42/249 (16%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ----VVQVACGQDHSLFLTDKGEVYSC 57
G N GQ G + ++ RV + +G +V ACG++H+L LT+ G V++
Sbjct: 175 GRNEKGQLG--------HGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAF 226
Query: 58 GWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
G GQ GLG+ + SP ++ + G + ++A + + + G L+ +G EY
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFSMIMDCKGNLYSFGCPEYG 284
Query: 117 QLASVTDSTQVN-----------VPR----CLHFSGVGK--------VRQAACGGTGCAV 153
QL +D + VPR + + G+ VR ACG V
Sbjct: 285 QLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLV 344
Query: 154 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALT 213
L+ + VF WG+G G+ L + + + P L L +F P S+I G + A++
Sbjct: 345 LDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKLFDF-PGRGASQIYAGYTCSFAVS 400
Query: 214 NKGELFVWG 222
G LF WG
Sbjct: 401 EVGGLFFWG 409
Score = 62.4 bits (150), Expect = 4e-10
Identities = 56/224 (25%), Positives = 97/224 (43%), Gaps = 21/224 (9%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VV +C HSL +T +G+++S G GQ G G +P + G L+ ++ A
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210
Query: 95 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
+ LA++ G +F +G ++ QL + V P + ++G + + ACG ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269
Query: 155 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 196
+ +G+++ +G YG LG + LV V I T G P
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
+ V + CG + L ++ +F WG G LG +D+ P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373
Score = 55.5 bits (132), Expect = 5e-08
Identities = 51/173 (29%), Positives = 72/173 (41%), Gaps = 23/173 (13%)
Query: 32 DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP--TKLGG 81
DGQ++ VACG +H+L L + V+S G+G G+ G P KL
Sbjct: 321 DGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKL-F 379
Query: 82 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 141
D G Q+ C AVS GGLF WG A+ T P+ + ++
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTMYPKAVQDLCGWRI 432
Query: 142 RQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIPPTLFGL 190
R ACG + V E + WG +G LG G + +S+ TL G+
Sbjct: 433 RSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGI 484
Score = 49.3 bits (116), Expect = 4e-06
Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)
Query: 81 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 137
G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR +
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200
Query: 138 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 196
+ AACG L G VF +G +G+ G AVP P + +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254
Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 243
++++ CG + KG L+ +G G LG I R + + P RV
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313
Query: 244 -----TMPGE--PV------DVACGVDHMVTL 262
T G+ PV DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 70.5 bits (171), Expect = 1e-12
Identities = 68/249 (27%), Positives = 110/249 (44%), Gaps = 42/249 (16%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ----VVQVACGQDHSLFLTDKGEVYSC 57
G N GQ G + ++ RV + +G +V ACG++H+L LT+ G V++
Sbjct: 175 GRNEKGQLG--------HGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAF 226
Query: 58 GWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
G GQ GLG+ + SP ++ + G + ++A + + + G L+ +G EY
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFSMIMDCKGNLYSFGCPEYG 284
Query: 117 QLASVTDSTQVN-----------VPR----CLHFSGVGK--------VRQAACGGTGCAV 153
QL +D + VPR + + G+ VR ACG V
Sbjct: 285 QLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLV 344
Query: 154 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALT 213
L+ + VF WG+G G+ L + + + P L L +F P S+I G + A++
Sbjct: 345 LDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKLFDF-PGRGASQIYAGYTCSFAVS 400
Query: 214 NKGELFVWG 222
G LF WG
Sbjct: 401 EVGGLFFWG 409
Score = 62.4 bits (150), Expect = 4e-10
Identities = 56/224 (25%), Positives = 97/224 (43%), Gaps = 21/224 (9%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VV +C HSL +T +G+++S G GQ G G +P + G L+ ++ A
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210
Query: 95 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
+ LA++ G +F +G ++ QL + V P + ++G + + ACG ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269
Query: 155 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 196
+ +G+++ +G YG LG + LV V I T G P
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
+ V + CG + L ++ +F WG G LG +D+ P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373
Score = 55.5 bits (132), Expect = 5e-08
Identities = 51/173 (29%), Positives = 72/173 (41%), Gaps = 23/173 (13%)
Query: 32 DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP--TKLGG 81
DGQ++ VACG +H+L L + V+S G+G G+ G P KL
Sbjct: 321 DGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKL-F 379
Query: 82 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 141
D G Q+ C AVS GGLF WG A+ T P+ + ++
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTMYPKAVQDLCGWRI 432
Query: 142 RQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIPPTLFGL 190
R ACG + V E + WG +G LG G + +S+ TL G+
Sbjct: 433 RSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGI 484
Score = 49.3 bits (116), Expect = 4e-06
Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)
Query: 81 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 137
G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR +
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200
Query: 138 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 196
+ AACG L G VF +G +G+ G AVP P + +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254
Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 243
++++ CG + KG L+ +G G LG I R + + P RV
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313
Query: 244 -----TMPGE--PV------DVACGVDHMVTL 262
T G+ PV DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 65.5 bits (158), Expect = 5e-11
Identities = 65/232 (28%), Positives = 99/232 (42%), Gaps = 14/232 (6%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
+ VACG + LTD+G + + G G++G G G S PT + L G ++QVA
Sbjct: 393 IKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEA-LLGYEMVQVACG 451
Query: 95 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
LA+S + LF WG + +L T + + P+ + + ++ CG +L
Sbjct: 452 ASHVLALSTERELFAWGRGDSGRLGLGTRESH-SCPQQVPMPPGQEAQRVVCGIDSSMIL 510
Query: 155 NGEGHVFVWGYGILGK----GPNLVESAVP-----EMIPPTLFGLTEFNPEIQVSRIRCG 205
G G K +L E VP E + TL G + E +S I G
Sbjct: 511 TVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLS-IDLG 569
Query: 206 LSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPG-EPVDVACG 255
+ AA+T G+ + +G N G LG P +V + G + VACG
Sbjct: 570 TAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACG 621
Score = 57.0 bits (136), Expect = 2e-08
Identities = 55/198 (27%), Positives = 79/198 (39%), Gaps = 22/198 (11%)
Query: 77 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW-------GNSEYLQLASVTDSTQVNV 129
T L + V+QVA V+ G L W G L A Q +
Sbjct: 323 TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQF-I 381
Query: 130 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG---ILGKGPNLVESAVPEMIPPT 186
R L ++ ACG A L G + +G G LG G +L + + P ++
Sbjct: 382 SRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEAL 440
Query: 187 LFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMP 246
L ++ ++ CG S AL+ + ELF WG+ G LG+G E P +V MP
Sbjct: 441 L--------GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492
Query: 247 --GEPVDVACGVDHMVTL 262
E V CG+D + L
Sbjct: 493 PGQEAQRVVCGIDSSMIL 510
Score = 48.9 bits (115), Expect = 5e-06
Identities = 42/154 (27%), Positives = 64/154 (41%), Gaps = 19/154 (12%)
Query: 33 GQVVQ-VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP------------TKL 79
GQ Q V CG D S+ LT G+ +CG + GL H ++ P T L
Sbjct: 494 GQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLL 553
Query: 80 GG---DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136
G D + I + T AV+A G + +G++++ QL + T +
Sbjct: 554 GSAPLDQEPLLSIDLGTAHSA--AVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE 611
Query: 137 GVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 170
G+ K+ ACG + E V+ WG G G+
Sbjct: 612 GI-KMAMVACGDAFTVAIGAESEVYSWGKGARGR 644
Score = 47.8 bits (112), Expect = 1e-05
Identities = 60/241 (24%), Positives = 96/241 (39%), Gaps = 31/241 (12%)
Query: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 93
++VQVACG H L L+ + E+++ G G G+ GLG S P ++ G +V
Sbjct: 444 EMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP-PGQEAQRVVC 502
Query: 94 YGDCCLAVSADGGLFGWGNSEYLQLA------SVTDSTQVNVPRCLHFSGVGK------- 140
D + ++ G G++ + +L V L F+ +G
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
Query: 141 VRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEI 197
+ G A + G + +G +G LG A P + GL I
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-----PCKVQGL----EGI 613
Query: 198 QVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV----TMPGEPVDVA 253
+++ + CG + A+ + E++ WGK RG LG R ED P V T P V+
Sbjct: 614 KMAMVACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLDETHPYTVTSVS 672
Query: 254 C 254
C
Sbjct: 673 C 673
Score = 33.1 bits (74), Expect = 0.26
Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWG 60
G+N +GQ G S ++Q +G ++ VACG ++ + + EVYS G G
Sbjct: 586 GSNQHGQLGTNTRRG-----SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKG 640
Query: 61 ADGQTG 66
A G+ G
Sbjct: 641 ARGRLG 646
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 62.8 bits (151), Expect = 3e-10
Identities = 57/202 (28%), Positives = 86/202 (42%), Gaps = 18/202 (8%)
Query: 74 SSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE-----YLQLASVTDSTQVN 128
S+P KL +G + QV V+ + L+ W N + + QL D
Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYR 415
Query: 129 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPP 185
P+ + +RQ +CG + EG ++ +G YG +G + + A PE++ P
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG----VDKVAGPEVLEP 471
Query: 186 TLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 245
NP QVS CG + LT E++ WG G LG+ ED Y P +V +
Sbjct: 472 MQLNFFLSNPVEQVS---CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV 528
Query: 246 PGEPVDVA--CGVDHMVTLAKS 265
P + VA CG D L +S
Sbjct: 529 PKALIIVAVQCGCDGTFLLTQS 550
Score = 54.3 bits (129), Expect = 1e-07
Identities = 67/248 (27%), Positives = 109/248 (43%), Gaps = 31/248 (12%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVV-QVACGQDHSLFLTDKGEVYSCG-- 58
G +GQ G + Y + V ++Q G+ + QV+CG D ++ +TD+G++Y+ G
Sbjct: 399 GTKLHGQLGHG--DKASYRQPKHVEKLQ---GKAIRQVSCGDDFTVCVTDEGQLYAFGSD 453
Query: 59 -WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAV-SADGGLFGWGNSEY- 115
+G G + + P +L L+ N ++ + GD + V + + ++ WG EY
Sbjct: 454 YYGCMGVDKVAGPEVL-EPMQLNFFLS--NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYG 510
Query: 116 -LQLASVTD---STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK- 170
L L S D +V+VP+ L V CG G +L G V G K
Sbjct: 511 RLGLDSEEDYYTPQKVDVPKALIIVAV------QCGCDGTFLLTQSGKVLACGLNEFNKL 564
Query: 171 GPN------LVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKN 224
G N + A E+ T F L + ++ I G + AA+ +G L +G N
Sbjct: 565 GLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN 624
Query: 225 IRGCLGIG 232
G LG+G
Sbjct: 625 KCGQLGVG 632
Score = 52.4 bits (124), Expect = 4e-07
Identities = 33/117 (28%), Positives = 57/117 (48%), Gaps = 6/117 (5%)
Query: 8 QCGRKVVENEIYSE-----SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGAD 62
QC ++ +E Y E S + + F ++ +A G+ H+ + ++G + + G
Sbjct: 568 QCMSGIINHEAYHEVPYTTSFTLAKQLSFY-KIRTIAPGKTHTAAIDERGRLLTFGCNKC 626
Query: 63 GQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
GQ G+G+Y LGG L G VI+V+ + +A + D +F WGN +LA
Sbjct: 627 GQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLA 683
Score = 50.8 bits (120), Expect = 1e-06
Identities = 56/212 (26%), Positives = 85/212 (40%), Gaps = 24/212 (11%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
V QV+CG +H + LT EVYS G G G+ GL +P K+ A + ++ V
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI-IVAVQCG 540
Query: 95 GDCCLAVSADGGLFGWGNSEYLQL-------ASVTDSTQVNVPRCLHFS-----GVGKVR 142
D ++ G + G +E+ +L + VP F+ K+R
Sbjct: 541 CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 600
Query: 143 QAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQV 199
A G T A ++ G + +G G LG G N + ++ L G QV
Sbjct: 601 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGK-------QV 652
Query: 200 SRIRCGLSRFAALTNKGELFVWGKNIRGCLGI 231
R+ CG A T+ +F WG G L +
Sbjct: 653 IRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
Score = 30.0 bits (66), Expect = 2.2
Identities = 10/34 (29%), Positives = 22/34 (64%)
Query: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGL 67
QV++V+CG + ++ TD +++ G G +G+ +
Sbjct: 651 QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 58.2 bits (139), Expect = 8e-09
Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)
Query: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 109 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 163
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 164 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 223
Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283
Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
Y LG P +P+ +
Sbjct: 284 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 342
Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
GL E E + S + CG S A+T G +F WG LG G+ ED
Sbjct: 343 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 402
Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
+ P V M G+ ++ V+ G H V L K
Sbjct: 403 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 433
Score = 42.0 bits (97), Expect = 6e-04
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 144
Query: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 145 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 194
Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 195 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 254
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 255 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 304
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 58.2 bits (139), Expect = 8e-09
Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)
Query: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 123 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 177
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 178 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 237
Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297
Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
Y LG P +P+ +
Sbjct: 298 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 356
Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
GL E E + S + CG S A+T G +F WG LG G+ ED
Sbjct: 357 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 416
Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
+ P V M G+ ++ V+ G H V L K
Sbjct: 417 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 447
Score = 42.0 bits (97), Expect = 6e-04
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 158
Query: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 159 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 208
Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 209 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 268
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 269 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 318
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 58.2 bits (139), Expect = 8e-09
Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)
Query: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 92 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206
Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
Y LG P +P+ +
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325
Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
GL E E + S + CG S A+T G +F WG LG G+ ED
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
+ P V M G+ ++ V+ G H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
Score = 42.0 bits (97), Expect = 6e-04
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127
Query: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177
Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 58.2 bits (139), Expect = 8e-09
Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)
Query: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 92 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206
Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
Y LG P +P+ +
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325
Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
GL E E + S + CG S A+T G +F WG LG G+ ED
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
+ P V M G+ ++ V+ G H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
Score = 42.0 bits (97), Expect = 6e-04
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127
Query: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177
Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 58.2 bits (139), Expect = 8e-09
Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)
Query: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 92 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206
Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
Y LG P +P+ +
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325
Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
GL E E + S + CG S A+T G +F WG LG G+ ED
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
+ P V M G+ ++ V+ G H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
Score = 42.0 bits (97), Expect = 6e-04
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127
Query: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177
Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 58.2 bits (139), Expect = 8e-09
Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)
Query: 2 GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
G N G GR VE S V + +VVQV+ G H+ LTD G V+ G
Sbjct: 92 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146
Query: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
D +G V V++VA+ D + ++ADG L+ G E QL
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206
Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
V + ++ VP+C+ G + + A CG ++ EGHV+ +G
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266
Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
Y LG P +P+ +
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325
Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
GL E E + S + CG S A+T G +F WG LG G+ ED
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385
Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
+ P V M G+ ++ V+ G H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
Score = 42.0 bits (97), Expect = 6e-04
Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
VVQ G H++ L+ G+VYS G +G G ++ S G V+QV+
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127
Query: 95 GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
A++ DG +F WG+ E ++ + V Q++VP V +
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177
Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
A G +L +G ++ G G LG+ P L + ++ P L
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
++ CG A++++G ++ +G + LG E + P +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 57.8 bits (138), Expect = 1e-08
Identities = 40/129 (31%), Positives = 61/129 (47%), Gaps = 8/129 (6%)
Query: 35 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
+ QV + HS+FL+ KG+VY+CG G G+ G G P + G L G N QVA
Sbjct: 179 IKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEG-LNGHNCSQVAAA 237
Query: 95 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
D + ++ DG ++ +G + + QL + + NVPR + + G T V
Sbjct: 238 KDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQ-------AKYLKGRTIIGVA 290
Query: 155 NGEGHVFVW 163
G H +W
Sbjct: 291 AGRFHTVLW 299
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 53.9 bits (128), Expect = 1e-07
Identities = 58/194 (29%), Positives = 78/194 (40%), Gaps = 22/194 (11%)
Query: 37 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 96
Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220
Query: 97 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 156
+ VS G ++ WG +E QLA T R L G R+A LN
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265
Query: 157 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
+G G P + P P L L + ++ S CG A +T G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319
Query: 217 ELFVWGKNIRGCLG 230
EL+ WG G LG
Sbjct: 320 ELYTWGWGKYGQLG 333
Score = 44.7 bits (104), Expect = 9e-05
Identities = 40/170 (23%), Positives = 67/170 (39%), Gaps = 22/170 (12%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G +GQ G +E E+ E + +Q + +VA G HS+ +++ G++Y GW
Sbjct: 183 GGGRHGQLGHGTLEAEL--EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNE 238
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLAS 120
GQ L N+ G V + AT + V GG + ++ +
Sbjct: 239 SGQLALPTRNLAED---------GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP 289
Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 170
P L +A+CG AV+ G ++ WG+G G+
Sbjct: 290 --------FPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
Score = 38.9 bits (89), Expect = 0.005
Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 74
V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339
Score = 31.2 bits (69), Expect = 0.99
Identities = 15/46 (32%), Positives = 22/46 (47%)
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
PE++ ++ G L G++F WG G LG G LE + P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 53.9 bits (128), Expect = 1e-07
Identities = 58/194 (29%), Positives = 78/194 (40%), Gaps = 22/194 (11%)
Query: 37 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 96
Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220
Query: 97 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 156
+ VS G ++ WG +E QLA T R L G R+A LN
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265
Query: 157 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
+G G P + P P L L + ++ S CG A +T G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319
Query: 217 ELFVWGKNIRGCLG 230
EL+ WG G LG
Sbjct: 320 ELYTWGWGKYGQLG 333
Score = 44.7 bits (104), Expect = 9e-05
Identities = 40/170 (23%), Positives = 67/170 (39%), Gaps = 22/170 (12%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
G +GQ G +E E+ E + +Q + +VA G HS+ +++ G++Y GW
Sbjct: 183 GGGRHGQLGHGTLEAEL--EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNE 238
Query: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLAS 120
GQ L N+ G V + AT + V GG + ++ +
Sbjct: 239 SGQLALPTRNLAED---------GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP 289
Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 170
P L +A+CG AV+ G ++ WG+G G+
Sbjct: 290 --------FPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
Score = 38.9 bits (89), Expect = 0.005
Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 36 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 74
V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339
Score = 31.2 bits (69), Expect = 0.99
Identities = 15/46 (32%), Positives = 22/46 (47%)
Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
PE++ ++ G L G++F WG G LG G LE + P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 48.9 bits (115), Expect = 5e-06
Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 30/190 (15%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
G+ +G+ GR E + ++ +GQ V Q+ CG L LT G V++ WG
Sbjct: 29 GDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT--WG 81
Query: 61 ADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL 118
LGH + P + G L G ++ VA CLAV G ++ WG++++ Q
Sbjct: 82 KGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 140
Query: 119 ASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESA 178
+ T +T P + K+ ACG + H W V+ A
Sbjct: 141 GNGT-TTVNRKPTLVQGLEGQKIMCVACGSS---------HSVAW---------TTVDVA 181
Query: 179 VPEMIPPTLF 188
P + P LF
Sbjct: 182 TPSVHEPVLF 191
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/156 (25%), Positives = 63/156 (40%), Gaps = 9/156 (5%)
Query: 107 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG 166
+F WG+ ++ +L S N+P+ + V Q CG L G V+ WG G
Sbjct: 25 VFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 167 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIR 226
+ + S V P + GL ++ + G A+ + G+++ WG N
Sbjct: 84 DYFRLGH--RSDVHVRKPQVVEGLRGK----KIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
Query: 227 GCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 260
G G G P V + G+ + VACG H V
Sbjct: 138 GQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173
Score = 28.9 bits (63), Expect = 4.9
Identities = 24/68 (35%), Positives = 28/68 (41%), Gaps = 8/68 (11%)
Query: 157 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNK 215
E VF WG G GK G E IP + L V +I CG ALT
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 74
Query: 216 GELFVWGK 223
G ++ WGK
Sbjct: 75 GVVWTWGK 82
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 47.8 bits (112), Expect = 1e-05
Identities = 47/189 (24%), Positives = 77/189 (40%), Gaps = 28/189 (14%)
Query: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
G+ +G+ GR E + ++ +GQ V Q+ CG L LT G V++ WG
Sbjct: 731 GDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT--WG 783
Query: 61 ADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
LGH + + ++ L G ++ VA CLAV G ++ WG++++ Q
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 843
Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAV 179
+ T +T P + K+ ACG + H W ++ A
Sbjct: 844 NGT-TTVNRKPMLVQGLEGQKIMCVACGSS---------HSVAW---------TTMDVAT 884
Query: 180 PEMIPPTLF 188
P + P LF
Sbjct: 885 PSVHEPVLF 893
Score = 40.0 bits (92), Expect = 0.002
Identities = 40/159 (25%), Positives = 65/159 (40%), Gaps = 10/159 (6%)
Query: 105 GGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 163
GGL F WG+ ++ +L S N+P+ + V Q CG L G V+ W
Sbjct: 724 GGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 782
Query: 164 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
G G + + + V ++ + E ++ + G A+ + G+++ WG
Sbjct: 783 GKGDYFRLGHRSDVHVRKL------QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGD 836
Query: 224 NIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 260
N G G G P V + G+ + VACG H V
Sbjct: 837 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 875
Score = 29.6 bits (65), Expect = 2.9
Identities = 50/188 (26%), Positives = 64/188 (34%), Gaps = 30/188 (15%)
Query: 50 DKGEVYSCGWGADGQTGLGHYN--------ITSSPTKLGGDLAGV--NVIQVATYGDCC- 98
D+GE + G ADG +YN +P G A + +GD C
Sbjct: 613 DEGE--AAGAAADGVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKHGDLCE 670
Query: 99 --LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 156
L SA G W + + V + GKV T C +
Sbjct: 671 VSLTSSAQGEAT-WPHPVLFHFGEIIQDKSVGN---WEYISTGKVSDNYALLTKCEM--- 723
Query: 157 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNK 215
G VF WG G GK G E IP + L V +I CG ALT
Sbjct: 724 GGLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 776
Query: 216 GELFVWGK 223
G ++ WGK
Sbjct: 777 GVVWTWGK 784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,763,109
Number of Sequences: 37866
Number of extensions: 478128
Number of successful extensions: 1311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 863
Number of HSP's gapped (non-prelim): 182
length of query: 267
length of database: 18,247,518
effective HSP length: 100
effective length of query: 167
effective length of database: 14,460,918
effective search space: 2414973306
effective search space used: 2414973306
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.