Guide to the Human Genome
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Search of human proteins with 169170558

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169170558 PREDICTED: RCC1-like G exchanging factor-like
[Homo sapiens]
         (267 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo...   563   e-161
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo...   563   e-161
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ...   561   e-160
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       119   2e-27
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            105   5e-23
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            105   5e-23
gi|4557445 regulator of chromosome condensation and BTB domain c...    91   1e-18
gi|61563742 hect domain and RLD 6 [Homo sapiens]                       87   1e-17
gi|110825982 hect domain and RLD 5 [Homo sapiens]                      87   2e-17
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      86   3e-17
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...    86   3e-17
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]    84   2e-16
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...    77   1e-14
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    77   1e-14
gi|6912330 deafness locus associated putative guanine nucleotide...    77   2e-14
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]     70   1e-12
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]      70   1e-12
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       65   5e-11
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      63   3e-10
gi|114796646 regulator of chromosome condensation 1 isoform b [H...    58   8e-09
gi|114796644 regulator of chromosome condensation 1 isoform a [H...    58   8e-09
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom...    58   8e-09
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]     58   8e-09
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]     58   8e-09
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]     58   8e-09
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]       58   1e-08
gi|63054860 RCC1 domain containing 1 [Homo sapiens]                    54   1e-07
gi|63054858 RCC1 domain containing 1 [Homo sapiens]                    54   1e-07
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    49   5e-06
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...    48   1e-05

>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
           sapiens]
          Length = 267

 Score =  563 bits (1450), Expect = e-161
 Identities = 267/267 (100%), Positives = 267/267 (100%)

Query: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
           ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120

Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
           VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180

Query: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240

Query: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
           WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267


>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
           sapiens]
          Length = 267

 Score =  563 bits (1450), Expect = e-161
 Identities = 267/267 (100%), Positives = 267/267 (100%)

Query: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
           ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120

Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
           VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180

Query: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240

Query: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
           WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267


>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
           sapiens]
          Length = 464

 Score =  561 bits (1445), Expect = e-160
 Identities = 266/267 (99%), Positives = 266/267 (99%)

Query: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
           ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317

Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
           VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377

Query: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437

Query: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
           WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464



 Score = 34.7 bits (78), Expect = 0.089
 Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%)

Query: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189
           K+  AACG  G  +L+ +      VWG G L K   L               ++ P+   
Sbjct: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165

Query: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243
           L    P E +V ++ CG +    LT++  +F  G N  G  G   +E++ +    RV   
Sbjct: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225

Query: 244 -TMPGEPVDVACGVDHMVTL 262
               G+ V VACG DH + L
Sbjct: 226 QDFDGQVVQVACGQDHSLFL 245


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  119 bits (299), Expect = 2e-27
 Identities = 82/239 (34%), Positives = 117/239 (48%), Gaps = 16/239 (6%)

Query: 32  DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 91
           D  V +VACG +HS+FL + GEVY+CG    GQ  LGH    + P ++G  LA  ++I V
Sbjct: 33  DRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQ--LGHEREGNKPEQIGA-LADQHIIHV 89

Query: 92  ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
           A      LA+S  G LF WG     QL  +T    V VPR +       + Q +CG   C
Sbjct: 90  ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149

Query: 152 AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSR 208
             L  +G  F WG   +G LG G      A P+ +  +L G       I ++++  G + 
Sbjct: 150 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG-------IPLAQVAAGGAH 201

Query: 209 FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM--PGEPVDVACGVDHMVTLAKS 265
             AL+  G +F WG N  G LG+   +D+  P  V +    + V ++CG +H   L KS
Sbjct: 202 SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKS 260



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 72/235 (30%), Positives = 110/235 (46%), Gaps = 17/235 (7%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRM-QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGW 59
           G  S GQ G    E+ +      V R+ Q  + Q ++QV+CG  H L L   G+ ++ G 
Sbjct: 109 GAGSDGQLGLMTTEDSV-----AVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGK 163

Query: 60  GADGQTGLG-HYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL 118
            + GQ GLG  +   +SP ++   L G+ + QVA  G    A+S  G +FGWG +   QL
Sbjct: 164 NSHGQLGLGKEFPSQASPQRVRS-LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQL 222

Query: 119 ASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESA 178
             ++D      P  +      KV   +CG    AVL   G VF +G G  G+  +  +S 
Sbjct: 223 G-LSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH--DSM 279

Query: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSR-FAALTNKGELFVWGKNIRGCLGIG 232
             E+ P  +  L       +V++I CG     A + + G ++ +G   RG LG G
Sbjct: 280 NDEVNPRRVLELM----GSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTG 330



 Score = 49.7 bits (117), Expect = 3e-06
 Identities = 38/137 (27%), Positives = 57/137 (41%), Gaps = 11/137 (8%)

Query: 130 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG 189
           P+   F     V++ ACGG     L  +G V+  G    G+  +  E   PE I      
Sbjct: 25  PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL--- 81

Query: 190 LTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP 249
                 +  +  + CG S   AL+++G+LF WG    G LG+   ED     R+      
Sbjct: 82  -----ADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQ 136

Query: 250 ---VDVACGVDHMVTLA 263
              + V+CG  H + LA
Sbjct: 137 QTILQVSCGNWHCLALA 153



 Score = 45.8 bits (107), Expect = 4e-05
 Identities = 28/81 (34%), Positives = 42/81 (51%), Gaps = 5/81 (6%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSL-FLTDKGEVYSCGWG 60
           G  S GQ G   + +E+     RV  ++    +V Q+ACG+ H+L F+   G +Y+ G G
Sbjct: 267 GAGSCGQLGHDSMNDEV--NPRRV--LELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCG 322

Query: 61  ADGQTGLGHYNITSSPTKLGG 81
           A GQ G GH      P+ + G
Sbjct: 323 ARGQLGTGHTCNVKCPSPVKG 343


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  105 bits (261), Expect = 5e-23
 Identities = 85/270 (31%), Positives = 125/270 (46%), Gaps = 22/270 (8%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
           GN S+GQ G   ++ EI  E     R  DF  + +V  V CG  H++F+ D G VY+CG 
Sbjct: 5   GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 60  GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
              GQ  LGH      P ++   L   N++ V+      LA++  G ++ WG     QL 
Sbjct: 61  NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117

Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 176
            V     + VPR +      ++ Q ACG      L+    VF WG   YG LG G +  +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177

Query: 177 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLED 236
              P+++  +L G+    P +QV+    G +    LT  G +F WG+N  G LG+    D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 237 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 264
           +Y P   +     + V + CG DH   L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 81/271 (29%), Positives = 117/271 (43%), Gaps = 38/271 (14%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  GQ G +           +  ++   D Q +V V+CG+ H+L L DKG+VY+ G  
Sbjct: 59  GCNDLGQLGHE-------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLD 111

Query: 61  ADGQTGL-GHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
           +DGQ GL G       P  +   L+ + ++QVA      LA+S    +F WG ++Y QL 
Sbjct: 112 SDGQLGLVGSEECIRVPRNI-KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170

Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKG----- 171
             TD  +   P+ L         Q A GG    VL   G +F WG   +G LG       
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230

Query: 172 --PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCL 229
             PNL++S   +                ++  I CG    AALT +G +F +G    G L
Sbjct: 231 YVPNLLKSLRSQ----------------KIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 230 GIGRLEDQYFPWRV--TMPGEPVDVACGVDH 258
           G      +  P +V   M     ++ACG  H
Sbjct: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQH 305



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 78/254 (30%), Positives = 110/254 (43%), Gaps = 11/254 (4%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G +S GQ G  V   E       +  + D   Q+VQVACG  HSL L+   EV+  G   
Sbjct: 109 GLDSDGQLGL-VGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSKASEVFCWGQNK 165

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
            GQ GLG      +  +L   L G+  +QVA  G     ++  G +FGWG +++ QL  +
Sbjct: 166 YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GL 224

Query: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPE 181
            D     VP  L      K+    CG    A L  EG VF +G G  G G     S   E
Sbjct: 225 NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHE 282

Query: 182 MIPPTLFGLTEFNPEIQVSRIRCGLSRFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           + P  +F L        V+ I CG    +A + + G ++ +G    G LG G   ++  P
Sbjct: 283 INPRKVFELM----GSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338

Query: 241 WRVTMPGEPVDVAC 254
           + V     P +  C
Sbjct: 339 FTVKGNWYPYNGQC 352


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  105 bits (261), Expect = 5e-23
 Identities = 85/270 (31%), Positives = 125/270 (46%), Gaps = 22/270 (8%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
           GN S+GQ G   ++ EI  E     R  DF  + +V  V CG  H++F+ D G VY+CG 
Sbjct: 5   GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 60  GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
              GQ  LGH      P ++   L   N++ V+      LA++  G ++ WG     QL 
Sbjct: 61  NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117

Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 176
            V     + VPR +      ++ Q ACG      L+    VF WG   YG LG G +  +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177

Query: 177 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLED 236
              P+++  +L G+    P +QV+    G +    LT  G +F WG+N  G LG+    D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 237 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 264
           +Y P   +     + V + CG DH   L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259



 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 81/271 (29%), Positives = 117/271 (43%), Gaps = 38/271 (14%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  GQ G +           +  ++   D Q +V V+CG+ H+L L DKG+VY+ G  
Sbjct: 59  GCNDLGQLGHE-------KSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLD 111

Query: 61  ADGQTGL-GHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
           +DGQ GL G       P  +   L+ + ++QVA      LA+S    +F WG ++Y QL 
Sbjct: 112 SDGQLGLVGSEECIRVPRNI-KSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170

Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKG----- 171
             TD  +   P+ L         Q A GG    VL   G +F WG   +G LG       
Sbjct: 171 LGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDR 230

Query: 172 --PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCL 229
             PNL++S   +                ++  I CG    AALT +G +F +G    G L
Sbjct: 231 YVPNLLKSLRSQ----------------KIVYICCGEDHTAALTKEGGVFTFGAGGYGQL 274

Query: 230 GIGRLEDQYFPWRV--TMPGEPVDVACGVDH 258
           G      +  P +V   M     ++ACG  H
Sbjct: 275 GHNSTSHEINPRKVFELMGSIVTEIACGRQH 305



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 78/254 (30%), Positives = 110/254 (43%), Gaps = 11/254 (4%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G +S GQ G  V   E       +  + D   Q+VQVACG  HSL L+   EV+  G   
Sbjct: 109 GLDSDGQLGL-VGSEECIRVPRNIKSLSDI--QIVQVACGYYHSLALSKASEVFCWGQNK 165

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
            GQ GLG      +  +L   L G+  +QVA  G     ++  G +FGWG +++ QL  +
Sbjct: 166 YGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GL 224

Query: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPE 181
            D     VP  L      K+    CG    A L  EG VF +G G  G G     S   E
Sbjct: 225 NDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHE 282

Query: 182 MIPPTLFGLTEFNPEIQVSRIRCGLSRFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           + P  +F L        V+ I CG    +A + + G ++ +G    G LG G   ++  P
Sbjct: 283 INPRKVFELM----GSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSP 338

Query: 241 WRVTMPGEPVDVAC 254
           + V     P +  C
Sbjct: 339 FTVKGNWYPYNGQC 352


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 74/253 (29%), Positives = 117/253 (46%), Gaps = 25/253 (9%)

Query: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVAC----GQDHSLFLTDKGEVYS 56
           +G N  G  G   V++ I        R+   +G+  ++AC       H +  T +GEV++
Sbjct: 70  LGTNCCGCLGLGDVQSTI-----EPRRLDSLNGK--KIACLSYGSGPHIVLATTEGEVFT 122

Query: 57  CGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
            G  A  Q G G  N    P  +  +L+   VI+VA      L +++DG +F WG +   
Sbjct: 123 WGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSG 182

Query: 117 QLASVTDSTQVNVPR----CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGP 172
           Q+ S +   Q  +PR    CL    V  +   ACG   C  +   G V+VWGY   G G 
Sbjct: 183 QVGSGSTVNQP-IPRRVTGCLQNKVVVTI---ACGQMCCMAVVDTGEVYVWGYN--GNGQ 236

Query: 173 NLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIG 232
             + ++  +  P  +  L      I+V R+ CG +    LT++G+++ WG N  G LG G
Sbjct: 237 LGLGNSGNQPTPCRVAALQG----IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG 292

Query: 233 RLEDQYFPWRVTM 245
              +Q +P  VT+
Sbjct: 293 NKSNQSYPTPVTV 305



 Score = 89.0 bits (219), Expect = 4e-18
 Identities = 68/226 (30%), Positives = 101/226 (44%), Gaps = 17/226 (7%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G+N+Y Q G     + +       H   +    QV++VACG  HSL LT  GEV++ G+ 
Sbjct: 124 GHNAYSQLGNGTTNHGLVP----CHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYN 179

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
             GQ G G       P ++ G L    V+ +A    CC+AV   G ++ WG +   QL  
Sbjct: 180 NSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGL 239

Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVES 177
                Q    R     G+ +V++ ACG     VL  EG V+ WG   YG LG G N    
Sbjct: 240 GNSGNQPTPCRVAALQGI-RVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQ 297

Query: 178 AVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
           + P  +        E +  I+++         AA T  G +++WG+
Sbjct: 298 SYPTPV------TVEKDRIIEIAACH-STHTSAAKTQGGHVYMWGQ 336



 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 77/243 (31%), Positives = 109/243 (44%), Gaps = 27/243 (11%)

Query: 34  QVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVI 89
           Q+++ AC      +  L+ T   E++  G    G  GLG    T  P +L  D      I
Sbjct: 43  QLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRL--DSLNGKKI 100

Query: 90  QVATYGD--CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQA 144
              +YG     +  + +G +F WG++ Y QL + T  T   +  C H S      +V + 
Sbjct: 101 ACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGT--TNHGLVPC-HISTNLSNKQVIEV 157

Query: 145 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201
           ACG     VL  +G VF WGY   G +G G     S V + IP  + G  +      V  
Sbjct: 158 ACGSYHSLVLTSDGEVFAWGYNNSGQVGSG-----STVNQPIPRRVTGCLQ---NKVVVT 209

Query: 202 IRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHM 259
           I CG     A+ + GE++VWG N  G LG+G   +Q  P RV  + G  V  VACG  H 
Sbjct: 210 IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHT 269

Query: 260 VTL 262
           + L
Sbjct: 270 LVL 272


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 75/260 (28%), Positives = 117/260 (45%), Gaps = 12/260 (4%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ-VACGQDHSLFLTDKGEVYSCGWG 60
           G+NS GQ GR+  +     E      +Q  +  +V  V+CG++HSL +  KG V++ G G
Sbjct: 48  GDNSRGQLGRRGAQRGELPEP-----IQALETLIVDLVSCGKEHSLAVCHKGRVFAWGAG 102

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
           ++GQ G+G +   S   K    L  + +IQV+      LA+S D  +F WG + + QL  
Sbjct: 103 SEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGL 162

Query: 121 VTD-STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAV 179
             +  +Q +  R     G+  + Q A GG     L+  G  F WG    G+      +  
Sbjct: 163 GKEFPSQASPQRVRSLEGI-PLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVP 221

Query: 180 PEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF 239
            +   P   G  +    + V  I CG +  A LT  G++F +G N  G LG     ++  
Sbjct: 222 VQSNKPLSVGALK---NLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRG 278

Query: 240 PWRV-TMPGEPVDVACGVDH 258
           P  V  + G    + CG  H
Sbjct: 279 PQLVERIDGLVSQIDCGSYH 298


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 65/231 (28%), Positives = 112/231 (48%), Gaps = 10/231 (4%)

Query: 12  KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN 71
           K  E + YS  H        + +++Q+ CG  HSL L+  GE+++ G    GQ G+G   
Sbjct: 117 KPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKF 176

Query: 72  ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 131
            +++  ++   LAGV + Q++      +A+S  G ++ WG +E  QL  +  +   + P 
Sbjct: 177 PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL-GLGHTESKDDPS 235

Query: 132 CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGL 190
            +      KV   ACGG+  A+L  +G +F +G G  G+ G N  ++ +   +   L G 
Sbjct: 236 LIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG- 294

Query: 191 TEFNPEIQVSRIRCG-LSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
                  +V++I CG     A +++ G++F +G    G LG G   DQ  P
Sbjct: 295 ------YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 72/240 (30%), Positives = 112/240 (46%), Gaps = 19/240 (7%)

Query: 35   VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
            VVQVA G      +T +G+VY+CG   +G+ GLG  + T    +    L+   V +VA +
Sbjct: 2994 VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVH 3053

Query: 95   --GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
              G    A++ DG +F WG  +  +L   +     + PR +      ++R  ACG +  A
Sbjct: 3054 SGGRHATALTVDGKVFSWGEGDDGKLGHFS-RMNCDKPRLIEALKTKRIRDIACGSSHSA 3112

Query: 153  VLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--S 207
             L   G ++ WG   YG LG G N  +   P+M+   L          +V ++ CG   +
Sbjct: 3113 ALTSSGELYTWGLGEYGRLGHGDNTTQ-LKPKMVKVLL--------GHRVIQVACGSRDA 3163

Query: 208  RFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPV-DVACGVDHMVTLAKS 265
            +  ALT++G +F WG    G LG G  E    P  +  + G+ V  + CG    + L KS
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223



 Score = 82.4 bits (202), Expect = 4e-16
 Identities = 73/242 (30%), Positives = 107/242 (44%), Gaps = 22/242 (9%)

Query: 35  VVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP---TKLGGDLAGVNVI 89
           +V++A   D  H L L   GEVYS G G  G+ G G       P   +   G  AG +V+
Sbjct: 495 IVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVV 554

Query: 90  QVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGT 149
            +A       A++A+G L+ WG   Y +L   +   +          G+ KV   ACG  
Sbjct: 555 HIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACGSG 613

Query: 150 GCAVL--NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRC 204
               L     G V+ WG   YG LG+G +      P++I        E   ++ V ++RC
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLI--------EKLQDLDVVKVRC 664

Query: 205 GLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMVTL 262
           G     ALT  G+++ WGK     LG G  E   +P  +  + G+ V DVA G  H + L
Sbjct: 665 GSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLAL 724

Query: 263 AK 264
            +
Sbjct: 725 TE 726



 Score = 79.3 bits (194), Expect = 3e-15
 Identities = 72/234 (30%), Positives = 104/234 (44%), Gaps = 18/234 (7%)

Query: 34   QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA- 92
            ++  +ACG  HS  LT  GE+Y+ G G  G+ G G  N T    K+   L G  VIQVA 
Sbjct: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVAC 3158

Query: 93   -TYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
             +     LA++ +G +F WG+ ++ +L     S   N+P+ +       V Q  CG    
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFS 3217

Query: 152  AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSR 208
              L   G V+ WG   Y  LG G     S V    P  + GL       ++  +  G   
Sbjct: 3218 LALTKSGVVWTWGKGDYFRLGHG-----SDVHVRKPQVVEGLR----GKKIVHVAVGALH 3268

Query: 209  FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPVD-VACGVDHMV 260
              A+T+ G+++ WG N  G  G G       P  V  + G+ +  VACG  H V
Sbjct: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 72/243 (29%), Positives = 113/243 (46%), Gaps = 34/243 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           V Q+AC +   L L+  G VY+  + +D          T +P  + G LA  N++++A +
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSD----------TLAPQLVQG-LASRNIVKIAAH 501

Query: 95  GD--CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH-FSG--VGK-VRQAACGG 148
            D    LA++A G ++ WG  +  +L    D+  +  P+ +  FSG   GK V   ACG 
Sbjct: 502 SDGHHYLALAATGEVYSWGCGDGGRLGH-GDTVPLEEPKVISAFSGKQAGKHVVHIACGS 560

Query: 149 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 205
           T  A +  EG ++ WG   YG LG G     S+  E IP  + GL      ++V  + CG
Sbjct: 561 TYSAAITAEGELYTWGRGNYGRLGHG-----SSEDEAIPMLVAGL----KGLKVIDVACG 611

Query: 206 L--SRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--TMPGEPVDVACGVDHMVT 261
              ++  A+T  G+++ WG    G LG G  +    P  +      + V V CG    + 
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIA 671

Query: 262 LAK 264
           L K
Sbjct: 672 LTK 674



 Score = 75.9 bits (185), Expect = 3e-14
 Identities = 64/202 (31%), Positives = 89/202 (44%), Gaps = 16/202 (7%)

Query: 36   VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
            V V  G  H L L+ +GEVYS G   DG+ G G+ +    P  +   L G+ V+ VA  G
Sbjct: 4042 VAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES-LRGIEVVDVAAGG 4100

Query: 96   DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL- 154
                 V+A G L+ WG   Y +L   +DS     P+ +      +V   ACG      L 
Sbjct: 4101 AHSACVTAAGDLYTWGKGRYGRLGH-SDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLC 4159

Query: 155  -NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
               +  V+ WG   YG LG+G +  +     M   +L GL        V ++ CG     
Sbjct: 4160 LTDDDTVWSWGDGDYGKLGRGGS--DGCKVPMKIDSLTGLG-------VVKVECGSQFSV 4210

Query: 211  ALTNKGELFVWGKNIRGCLGIG 232
            ALT  G ++ WGK     LG G
Sbjct: 4211 ALTKSGAVYTWGKGDYHRLGHG 4232



 Score = 74.7 bits (182), Expect = 8e-14
 Identities = 65/235 (27%), Positives = 109/235 (46%), Gaps = 12/235 (5%)

Query: 36   VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG-DLAGVNVIQVATY 94
            VQ+  G+     +T  G++Y+ G+GA G+ G+G     S+PT L       +  + V + 
Sbjct: 3988 VQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSG 4047

Query: 95   GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
            G  CLA+S++G ++ WG +E  +L    + +  + PR +      +V   A GG   A +
Sbjct: 4048 GKHCLALSSEGEVYSWGEAEDGKLGH-GNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106

Query: 155  NGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--SRFAAL 212
               G ++ WG G  G+   L  S   + + P L    + +   +V  I CG   ++   L
Sbjct: 4107 TAAGDLYTWGKGRYGR---LGHSDSEDQLKPKLVEALQGH---RVVDIACGSGDAQTLCL 4160

Query: 213  TNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPG-EPVDVACGVDHMVTLAKS 265
            T+   ++ WG    G LG G  +    P ++ ++ G   V V CG    V L KS
Sbjct: 4161 TDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKS 4215



 Score = 67.4 bits (163), Expect = 1e-11
 Identities = 59/192 (30%), Positives = 87/192 (45%), Gaps = 10/192 (5%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT- 93
           VV +ACG  +S  +T +GE+Y+ G G  G+ G G     + P  + G L G+ VI VA  
Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG-LKGLKVIDVACG 611

Query: 94  YGDC-CLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
            GD   LAV+ +G ++ WG+ +Y +L     S     P+ +       V +  CG     
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGR-GGSDGCKTPKLIEKLQDLDVVKVRCGSQFSI 670

Query: 153 VLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAAL 212
            L  +G V+ WG G   +  +  E  V    P  L GL       +V  +  G +   AL
Sbjct: 671 ALTKDGQVYSWGKGDNQRLGHGTEEHV--RYPKLLEGLQGK----KVIDVAAGSTHCLAL 724

Query: 213 TNKGELFVWGKN 224
           T   E+  WG N
Sbjct: 725 TEDSEVHSWGSN 736



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 64/214 (29%), Positives = 92/214 (42%), Gaps = 19/214 (8%)

Query: 59   WGADGQTGLGHYNITSSPTKLGG---DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 115
            WG + +  LG   +  S  K+      L+ +NV+QVA       AV+ +G ++  G +  
Sbjct: 2964 WGLNDKDQLG--GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATN 3021

Query: 116  LQLASVTDSTQVNVPRCLHFSGVGKVRQAAC--GGTGCAVLNGEGHVFVWGYGILGKGPN 173
             +L     S  V +PR +       V++ A   GG     L  +G VF WG G  GK  +
Sbjct: 3022 GRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGH 3081

Query: 174  L--VESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGI 231
               +    P +I        E     ++  I CG S  AALT+ GEL+ WG    G LG 
Sbjct: 3082 FSRMNCDKPRLI--------EALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGH 3133

Query: 232  GRLEDQYFP--WRVTMPGEPVDVACGVDHMVTLA 263
            G    Q  P   +V +    + VACG     TLA
Sbjct: 3134 GDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLA 3167



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 41/133 (30%), Positives = 65/133 (48%), Gaps = 4/133 (3%)

Query: 34  QVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 91
           +V+ VACG     +L +T+ G+V+S G G  G+ G G  +   +P KL   L  ++V++V
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTP-KLIEKLQDLDVVKV 662

Query: 92  ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
                  +A++ DG ++ WG  +  +L   T+   V  P+ L      KV   A G T C
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE-HVRYPKLLEGLQGKKVIDVAAGSTHC 721

Query: 152 AVLNGEGHVFVWG 164
             L  +  V  WG
Sbjct: 722 LALTEDSEVHSWG 734



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 40/116 (34%), Positives = 57/116 (49%), Gaps = 5/116 (4%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G+  YG+ GR   +         + ++QD D  VV+V CG   S+ LT  G+VYS G G 
Sbjct: 630 GDGDYGKLGRGGSDG--CKTPKLIEKLQDLD--VVKVRCGSQFSIALTKDGQVYSWGKGD 685

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQ 117
           + + G G       P  L G L G  VI VA     CLA++ D  +  WG+++  Q
Sbjct: 686 NQRLGHGTEEHVRYPKLLEG-LQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 38/113 (33%), Positives = 57/113 (50%), Gaps = 2/113 (1%)

Query: 35   VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
            VV+V CG   S+ LT  G VY+ G G   + G G  +    P ++ G L G  VI +AT 
Sbjct: 4199 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQG-LQGKKVIAIATG 4257

Query: 95   GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 147
               C+  + DG ++ WG+++  QL   T +  +  PR +      KV + ACG
Sbjct: 4258 SLHCVCCTEDGEVYTWGDNDEGQLGDGT-TNAIQRPRLVAALQGKKVNRVACG 4309



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 59/226 (26%), Positives = 81/226 (35%), Gaps = 69/226 (30%)

Query: 96   DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR-C---------------------- 132
            D  L+    G ++GWG++   QL  + +  +V VP  C                      
Sbjct: 3943 DWTLSAGGSGTIYGWGHNHRGQLGGI-EGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001

Query: 133  ----LHFSGVGKVRQAACGGT---------------------------GCAVLNGEGHVF 161
                L+ +G G   +   GGT                            C  L+ EG V+
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061

Query: 162  VWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGEL 218
             WG    G LG G N      P +I        E    I+V  +  G +  A +T  G+L
Sbjct: 4062 SWGEAEDGKLGHG-NRSPCDRPRVI--------ESLRGIEVVDVAAGGAHSACVTAAGDL 4112

Query: 219  FVWGKNIRGCLGIGRLEDQYFPWRV-TMPG-EPVDVACGVDHMVTL 262
            + WGK   G LG    EDQ  P  V  + G   VD+ACG     TL
Sbjct: 4113 YTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTL 4158



 Score = 36.6 bits (83), Expect = 0.024
 Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 4/76 (5%)

Query: 20   SESH--RVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 76
            S+ H  R  ++Q   G+ V+ +A G  H +  T+ GEVY+ G   +GQ G G  N    P
Sbjct: 4233 SDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP 4292

Query: 77   TKLGGDLAGVNVIQVA 92
             +L   L G  V +VA
Sbjct: 4293 -RLVAALQGKKVNRVA 4307


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Homo sapiens]
          Length = 531

 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 66/213 (30%), Positives = 99/213 (46%), Gaps = 18/213 (8%)

Query: 44  HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 103
           H L  T+ G VY+ G     Q G G  N   +P ++  +L    V++VA      +A++A
Sbjct: 86  HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145

Query: 104 DGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 160
           DG +F WG +   Q+ S + + Q     V  CLH   + +V   ACG T    +   G V
Sbjct: 146 DGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGIACGQTSSMAVLDNGEV 202

Query: 161 FVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGE 217
           + WGY   G LG G N       ++ P  +  L      + V++I CG +   ALT++G 
Sbjct: 203 YGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQIVCGYAHTLALTDEGL 253

Query: 218 LFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 250
           L+ WG N  G LG G   +   P  + +  E V
Sbjct: 254 LYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 15/224 (6%)

Query: 45  SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA-TYGDCCLAVSA 103
           +L++TD  EV+  G       G G    T  P KL G L G  +  ++   G   L  + 
Sbjct: 34  ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG-LCGKKIKSLSYGSGPHVLLSTE 92

Query: 104 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 163
           DG ++ WG++ Y QL + T +  +   +      + +V + ACG      L  +G VF W
Sbjct: 93  DGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW 152

Query: 164 GY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFV 220
           GY   G +G G    +        PT   +T      +V  I CG +   A+ + GE++ 
Sbjct: 153 GYNNCGQVGSGSTANQ--------PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204

Query: 221 WGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDHMVTL 262
           WG N  G LG+G   +Q  P RV          + CG  H + L
Sbjct: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 64/225 (28%), Positives = 95/225 (42%), Gaps = 15/225 (6%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G+N Y Q G       I       + +     QVV+VACG  HS+ L   GEV++ G+  
Sbjct: 100 GHNGYSQLGNGTTNQGIAPVQVCTNLLIK---QVVEVACGSHHSMALAADGEVFAWGYNN 156

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
            GQ G G      +P K+   L    V+ +A      +AV  +G ++GWG +   QL   
Sbjct: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216

Query: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESA 178
            +  Q+   R      V  V Q  CG      L  EG ++ WG   YG LG G N     
Sbjct: 217 NNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG-NKNNLL 274

Query: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
            P  I      + E    ++++      +  AA T  G +++WG+
Sbjct: 275 SPAHI------MVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 69/250 (27%), Positives = 118/250 (47%), Gaps = 25/250 (10%)

Query: 2    GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
            G+  YG+ G    + +      R  +++   G+ VVQ++CG  HS  +T  G++++ G G
Sbjct: 4107 GDGDYGKLGHGNSDRQ-----RRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG 4161

Query: 61   ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGL-FGWGNSEYLQLA 119
              G+ GLG+ +    P ++   L G  + QVA   +  LAVSADG + + +G+ +Y +L 
Sbjct: 4162 DYGRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLG 4220

Query: 120  SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGIL-----GKGPNL 174
                + + +  +     G+G +++ ACG      L  +GHV+ +G   L     G+  N 
Sbjct: 4221 LGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNH 4279

Query: 175  VESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRL 234
                 P+ IP  L G+        +  +  G     AL + G+++ WG N  G LG+G  
Sbjct: 4280 NR---PQQIP-VLAGVI-------IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHT 4328

Query: 235  EDQYFPWRVT 244
                 P  VT
Sbjct: 4329 NHVREPTLVT 4338



 Score = 71.2 bits (173), Expect = 9e-13
 Identities = 66/240 (27%), Positives = 104/240 (43%), Gaps = 23/240 (9%)

Query: 2   GNNSYGQCGRKVVENE-----IYSESHRVHRMQDFDGQVVQVACGQD-HSLFLTDKGEVY 55
           G  SYG+ G     N+     +  E HR  +        V  + G D H+L  T +GEV+
Sbjct: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKK-------VSSSKGSDGHTLAFTTEGEVF 480

Query: 56  SCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 115
           S G G  G+ G G+ +    P  + G L G  V+ V+       AV+ DG L+ WG  ++
Sbjct: 481 SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540

Query: 116 LQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLV 175
            +L    DS   N+P  +    +  V + +CG +    L+ +G   VW +G  G    L 
Sbjct: 541 GRLGH-GDSNSRNIPTLV--KDISNVGEVSCGSSHTIALSKDGRT-VWSFG-GGDNGKLG 595

Query: 176 ESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLE 235
                 +  P +    E    + + ++  G     ALT+ G+++ WG     CLG G  E
Sbjct: 596 HGDTNRVYKPKVI---EALQGMFIRKVCAGSQSSLALTSTGQVYAWG--CGACLGCGSSE 650



 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 59/202 (29%), Positives = 92/202 (45%), Gaps = 18/202 (8%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VV V+ G  HS  +T+ GE+Y+ G G  G+ G G  N  + PT L  D++  NV +V+  
Sbjct: 513 VVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPT-LVKDIS--NVGEVSCG 569

Query: 95  GDCCLAVSADGGL---FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 151
               +A+S DG     FG G++  L      D+ +V  P+ +       +R+   G    
Sbjct: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHG---DTNRVYKPKVIEALQGMFIRKVCAGSQSS 626

Query: 152 AVLNGEGHVFVWGYGI-LGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
             L   G V+ WG G  LG G +   +  P++I        E     ++  +  G S   
Sbjct: 627 LALTSTGQVYAWGCGACLGCGSSEATALRPKLI--------EELAATRIVDVSIGDSHCL 678

Query: 211 ALTNKGELFVWGKNIRGCLGIG 232
           AL++  E++ WG N  G  G G
Sbjct: 679 ALSHDNEVYAWGNNSMGQCGQG 700



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 73/267 (27%), Positives = 107/267 (40%), Gaps = 38/267 (14%)

Query: 13   VVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNI 72
            V E+E+         +   D Q++  A  +     L  K +VY  G G  GQ      N+
Sbjct: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNV 4017

Query: 73   TSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG----------GLFGWGNSEYLQLASVT 122
                       A     QV    +C   + A+G          G  G GNS+ L + +V 
Sbjct: 4018 MVPAAAPSFSQAQ----QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073

Query: 123  DSTQVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESA 178
             + Q  V   L  S         CG  G ++ L   G VF WG   YG LG G N     
Sbjct: 4074 SALQGFVVTQLVTS---------CGSDGHSMALTESGEVFSWGDGDYGKLGHG-NSDRQR 4123

Query: 179  VPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQY 238
             P  I        E     +V ++ CG    A +T+ G+LF +G    G LG+G   ++ 
Sbjct: 4124 RPRQI--------EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175

Query: 239  FPWRVT-MPGEPV-DVACGVDHMVTLA 263
             P RVT + G  +  VACG++H + ++
Sbjct: 4176 LPERVTALEGYQIGQVACGLNHTLAVS 4202



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 62/218 (28%), Positives = 84/218 (38%), Gaps = 18/218 (8%)

Query: 53  EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 112
           EVY  G  +  Q   G       P KL    +    I+   Y  C   +S DG +   G 
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQP-KLAPSFSDAQTIEAGQY--CTFVISTDGSVRACGK 429

Query: 113 SEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 166
             Y +L  + DS   +  + L F     + KV  +            EG VF WG   YG
Sbjct: 430 GSYGRLG-LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488

Query: 167 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIR 226
            LG G N      P++I   L G         V  +  G    AA+T  GEL+ WG+   
Sbjct: 489 KLGHG-NSSTQKYPKLIQGPLQGKV-------VVCVSAGYRHSAAVTEDGELYTWGEGDF 540

Query: 227 GCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAK 264
           G LG G    +  P  V       +V+CG  H + L+K
Sbjct: 541 GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSK 578



 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 57/216 (26%), Positives = 93/216 (43%), Gaps = 21/216 (9%)

Query: 32  DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD-LAGVNVIQ 90
           D Q ++   GQ  +  ++  G V +CG G+ G+ GLG  N  S+  KL  +    +  + 
Sbjct: 404 DAQTIEA--GQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVS 461

Query: 91  VATYGD-CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGG- 148
            +   D   LA + +G +F WG+ +Y +L     STQ   P+ +     GKV      G 
Sbjct: 462 SSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQ-KYPKLIQGPLQGKVVVCVSAGY 520

Query: 149 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 205
              A +  +G ++ WG   +G LG G +   + +P ++               V  + CG
Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGHGDSNSRN-IPTLVKDI----------SNVGEVSCG 569

Query: 206 LSRFAALTNKGE-LFVWGKNIRGCLGIGRLEDQYFP 240
            S   AL+  G  ++ +G    G LG G     Y P
Sbjct: 570 SSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKP 605



 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 32/117 (27%), Positives = 56/117 (47%), Gaps = 6/117 (5%)

Query: 19  YSESHRVHR---MQDFDGQVVQVAC-GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 74
           + +++RV++   ++   G  ++  C G   SL LT  G+VY+  WG     G G    T+
Sbjct: 596 HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYA--WGCGACLGCGSSEATA 653

Query: 75  SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 131
              KL  +LA   ++ V+     CLA+S D  ++ WGN+   Q      +  +  P+
Sbjct: 654 LRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPK 710



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 27/63 (42%), Positives = 37/63 (58%), Gaps = 2/63 (3%)

Query: 35   VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
            +  VA G +H+L L   G+VY+ G  ++GQ GLGH N    PT + G L G NV Q++  
Sbjct: 4293 IEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG-LQGKNVRQISA- 4350

Query: 95   GDC 97
            G C
Sbjct: 4351 GRC 4353



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 21/70 (30%), Positives = 34/70 (48%)

Query: 34  QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 93
           ++V V+ G  H L L+   EVY+ G  + GQ G G+     +  K    L G+ + Q++ 
Sbjct: 666 RIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISA 725

Query: 94  YGDCCLAVSA 103
                LA +A
Sbjct: 726 GTSHSLAWTA 735


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 69/240 (28%), Positives = 108/240 (45%), Gaps = 22/240 (9%)

Query: 36  VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
           V ++CG +HS  +T   ++Y  G    GQ GLG  +  S PT +         +++A  G
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV--KALKPEKVKLAACG 95

Query: 96  DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
                VS +GG     G  N   L L    +    +V     F+   K++Q + G    A
Sbjct: 96  RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153

Query: 153 VLNGEGHVFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
            L  +G +F+WG    G+    N+    VP+ +       T   P   VS I CG    A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203

Query: 211 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 267
            +T  GEL+V+G+   G LG+    L +   P  V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263



 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 72/320 (22%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G+N++GQ G  +      S+   V  ++    +V   ACG++H+L  T+ G VY+ G   
Sbjct: 60  GSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAACGRNHTLVSTEGGNVYATGGNN 115

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL--- 118
           +GQ GLG     ++   +    +   + Q++   +   A++ DG LF WG++   Q+   
Sbjct: 116 EGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLK 175

Query: 119 --ASVTDSTQVNVPRCLHFSGVG------------------------------------- 139
             ++V    QV + + + +   G                                     
Sbjct: 176 NVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTP 235

Query: 140 --------KVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLF 188
                   KV Q ACGG    VL  E  V+ +G   +G LG G  L E++ P++I     
Sbjct: 236 QLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVI----- 289

Query: 189 GLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE 248
              E   +  +S I CG +  A +T+ G ++ +G    G LG+G LE+    +  T+   
Sbjct: 290 ---ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG-LENFTNHFIPTLCSN 345

Query: 249 PVD-----VACGVDHMVTLA 263
            +      VACG  HMV  A
Sbjct: 346 FLRFIVKLVACGGCHMVVFA 365


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 77.4 bits (189), Expect = 1e-14
 Identities = 69/240 (28%), Positives = 108/240 (45%), Gaps = 22/240 (9%)

Query: 36  VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 95
           V ++CG +HS  +T   ++Y  G    GQ GLG  +  S PT +         +++A  G
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV--KALKPEKVKLAACG 95

Query: 96  DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 152
                VS +GG     G  N   L L    +    +V     F+   K++Q + G    A
Sbjct: 96  RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153

Query: 153 VLNGEGHVFVWGYGILGK--GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFA 210
            L  +G +F+WG    G+    N+    VP+ +       T   P   VS I CG    A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203

Query: 211 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 267
            +T  GEL+V+G+   G LG+    L +   P  V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263



 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 80/320 (25%), Positives = 133/320 (41%), Gaps = 72/320 (22%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G+N++GQ G  +      S+   V  ++    +V   ACG++H+L  T+ G VY+ G   
Sbjct: 60  GSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAACGRNHTLVSTEGGNVYATGGNN 115

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL--- 118
           +GQ GLG     ++   +    +   + Q++   +   A++ DG LF WG++   Q+   
Sbjct: 116 EGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLK 175

Query: 119 --ASVTDSTQVNVPRCLHFSGVG------------------------------------- 139
             ++V    QV + + + +   G                                     
Sbjct: 176 NVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTP 235

Query: 140 --------KVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLF 188
                   KV Q ACGG    VL  E  V+ +G   +G LG G  L E++ P++I     
Sbjct: 236 QLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVI----- 289

Query: 189 GLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGE 248
              E   +  +S I CG +  A +T+ G ++ +G    G LG+G LE+    +  T+   
Sbjct: 290 ---ENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLG-LENFTNHFIPTLCSN 345

Query: 249 PVD-----VACGVDHMVTLA 263
            +      VACG  HMV  A
Sbjct: 346 FLRFIVKLVACGGCHMVVFA 365


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 22/237 (9%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
           G NSYGQ G    E+ +  +     ++ DF     V ++  G  HS  +TD G+++ CG 
Sbjct: 21  GANSYGQLGLGHKEDVLLPQ-----QLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75

Query: 60  GADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQ 117
             DGQ GLGH       +P K    L G  + QVA   D  + ++ +G +   G++ + Q
Sbjct: 76  NKDGQLGLGHTEDIPYFTPCK---SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQ 132

Query: 118 LASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVES 177
           L       +  VP+ +      KV   A G          G VF WG G+   G  L   
Sbjct: 133 LGVPHGPRRCVVPQAIELH-KEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRL--- 188

Query: 178 AVPEMIPPTLFGLTEFN--PEIQVSRIRC---GLSRFAALTNKGELFVWGKNIRGCL 229
             P    P  F   E +    ++ S+  C   G    A+LT+ GE++VWG N  G L
Sbjct: 189 -CPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL 244



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 73/265 (27%), Positives = 107/265 (40%), Gaps = 48/265 (18%)

Query: 31  FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 90
           F   + QVACG D ++ LT+ G+V SCG  + GQ G+ H            +L    V+ 
Sbjct: 99  FGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVC 157

Query: 91  VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVR-------Q 143
           +A      +A +A G +F WG      LAS            L F+     R       +
Sbjct: 158 IAAGLRHAVAATASGIVFQWGTG----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSK 213

Query: 144 AAC---GGTGCAVLNGEGHVFVWGYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEI 197
           A C   G    A L   G V+VWG    G+  N  E+A   VP+ I    F         
Sbjct: 214 AMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCF------QNE 265

Query: 198 QVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-------------- 243
           +V+ I  G +   A T  G++F WG+   G L  GR  + Y  W++              
Sbjct: 266 KVTAIWSGWTHLVAQTETGKMFTWGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPN 323

Query: 244 TMPGEP------VDVACGVDHMVTL 262
           +MP  P       +V+CG +H + +
Sbjct: 324 SMPSSPHCLTGATEVSCGSEHNLAI 348



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 13/111 (11%)

Query: 160 VFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
           +F WG   YG LG G +  +  +P+        L +F     V RI  G    A +T+ G
Sbjct: 17  LFAWGANSYGQLGLG-HKEDVLLPQQ-------LNDFCKPRSVRRITGGGGHSAVVTDGG 68

Query: 217 ELFVWGKNIRGCLGIGRLED-QYFPWRVTMPGEPV-DVACGVDHMVTLAKS 265
           +LFV G N  G LG+G  ED  YF    ++ G P+  VACG D  + L ++
Sbjct: 69  DLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119


>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 68/249 (27%), Positives = 110/249 (44%), Gaps = 42/249 (16%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ----VVQVACGQDHSLFLTDKGEVYSC 57
           G N  GQ G        + ++ RV   +  +G     +V  ACG++H+L LT+ G V++ 
Sbjct: 175 GRNEKGQLG--------HGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAF 226

Query: 58  GWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
           G    GQ GLG+  +   SP ++  +  G  + ++A   +  + +   G L+ +G  EY 
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFSMIMDCKGNLYSFGCPEYG 284

Query: 117 QLASVTDSTQVN-----------VPR----CLHFSGVGK--------VRQAACGGTGCAV 153
           QL   +D   +            VPR     +  +  G+        VR  ACG     V
Sbjct: 285 QLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLV 344

Query: 154 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALT 213
           L+ +  VF WG+G  G+   L  +   + + P L  L +F P    S+I  G +   A++
Sbjct: 345 LDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKLFDF-PGRGASQIYAGYTCSFAVS 400

Query: 214 NKGELFVWG 222
             G LF WG
Sbjct: 401 EVGGLFFWG 409



 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 56/224 (25%), Positives = 97/224 (43%), Gaps = 21/224 (9%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VV  +C   HSL +T +G+++S G    GQ G G      +P  + G L+   ++  A  
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210

Query: 95  GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
            +  LA++  G +F +G ++  QL     +  V  P  + ++G   + + ACG     ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269

Query: 155 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 196
           + +G+++ +G   YG LG   +               LV   V   I  T  G     P 
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329

Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           + V  + CG +    L ++  +F WG    G LG    +D+  P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 51/173 (29%), Positives = 72/173 (41%), Gaps = 23/173 (13%)

Query: 32  DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP--TKLGG 81
           DGQ++         VACG +H+L L  +  V+S G+G  G+ G         P   KL  
Sbjct: 321 DGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKL-F 379

Query: 82  DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 141
           D  G    Q+     C  AVS  GGLF WG       A+ T       P+ +      ++
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTMYPKAVQDLCGWRI 432

Query: 142 RQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIPPTLFGL 190
           R  ACG +   V   E  +  WG    +G LG G +  +S+       TL G+
Sbjct: 433 RSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGI 484



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)

Query: 81  GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 137
           G LAGV V  V + G C    L ++ +G L+ WG +E  QL    D+ +V  PR +    
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200

Query: 138 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 196
              +  AACG      L   G VF +G   +G+ G      AVP   P  +     +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254

Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 243
             ++++ CG      +  KG L+ +G    G LG       I R +      +  P RV 
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313

Query: 244 -----TMPGE--PV------DVACGVDHMVTL 262
                T  G+  PV      DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 68/249 (27%), Positives = 110/249 (44%), Gaps = 42/249 (16%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ----VVQVACGQDHSLFLTDKGEVYSC 57
           G N  GQ G        + ++ RV   +  +G     +V  ACG++H+L LT+ G V++ 
Sbjct: 175 GRNEKGQLG--------HGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGSVFAF 226

Query: 58  GWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYL 116
           G    GQ GLG+  +   SP ++  +  G  + ++A   +  + +   G L+ +G  EY 
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMACGAEFSMIMDCKGNLYSFGCPEYG 284

Query: 117 QLASVTDSTQVN-----------VPR----CLHFSGVGK--------VRQAACGGTGCAV 153
           QL   +D   +            VPR     +  +  G+        VR  ACG     V
Sbjct: 285 QLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLV 344

Query: 154 LNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALT 213
           L+ +  VF WG+G  G+   L  +   + + P L  L +F P    S+I  G +   A++
Sbjct: 345 LDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKLFDF-PGRGASQIYAGYTCSFAVS 400

Query: 214 NKGELFVWG 222
             G LF WG
Sbjct: 401 EVGGLFFWG 409



 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 56/224 (25%), Positives = 97/224 (43%), Gaps = 21/224 (9%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VV  +C   HSL +T +G+++S G    GQ G G      +P  + G L+   ++  A  
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210

Query: 95  GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
            +  LA++  G +F +G ++  QL     +  V  P  + ++G   + + ACG     ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269

Query: 155 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 196
           + +G+++ +G   YG LG   +               LV   V   I  T  G     P 
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329

Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           + V  + CG +    L ++  +F WG    G LG    +D+  P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 51/173 (29%), Positives = 72/173 (41%), Gaps = 23/173 (13%)

Query: 32  DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP--TKLGG 81
           DGQ++         VACG +H+L L  +  V+S G+G  G+ G         P   KL  
Sbjct: 321 DGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKL-F 379

Query: 82  DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 141
           D  G    Q+     C  AVS  GGLF WG       A+ T       P+ +      ++
Sbjct: 380 DFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTMYPKAVQDLCGWRI 432

Query: 142 RQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIPPTLFGL 190
           R  ACG +   V   E  +  WG    +G LG G +  +S+       TL G+
Sbjct: 433 RSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGI 484



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)

Query: 81  GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 137
           G LAGV V  V + G C    L ++ +G L+ WG +E  QL    D+ +V  PR +    
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200

Query: 138 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 196
              +  AACG      L   G VF +G   +G+ G      AVP   P  +     +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254

Query: 197 IQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 243
             ++++ CG      +  KG L+ +G    G LG       I R +      +  P RV 
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313

Query: 244 -----TMPGE--PV------DVACGVDHMVTL 262
                T  G+  PV      DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 65.5 bits (158), Expect = 5e-11
 Identities = 65/232 (28%), Positives = 99/232 (42%), Gaps = 14/232 (6%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           +  VACG   +  LTD+G + + G G++G  G G     S PT +   L G  ++QVA  
Sbjct: 393 IKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEA-LLGYEMVQVACG 451

Query: 95  GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
               LA+S +  LF WG  +  +L   T  +  + P+ +      + ++  CG     +L
Sbjct: 452 ASHVLALSTERELFAWGRGDSGRLGLGTRESH-SCPQQVPMPPGQEAQRVVCGIDSSMIL 510

Query: 155 NGEGHVFVWGYGILGK----GPNLVESAVP-----EMIPPTLFGLTEFNPEIQVSRIRCG 205
              G     G     K      +L E  VP     E +  TL G    + E  +S I  G
Sbjct: 511 TVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLS-IDLG 569

Query: 206 LSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPG-EPVDVACG 255
            +  AA+T  G+ + +G N  G LG         P +V  + G +   VACG
Sbjct: 570 TAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACG 621



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 55/198 (27%), Positives = 79/198 (39%), Gaps = 22/198 (11%)

Query: 77  TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW-------GNSEYLQLASVTDSTQVNV 129
           T L   +    V+QVA        V+  G L  W       G    L  A      Q  +
Sbjct: 323 TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQF-I 381

Query: 130 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG---ILGKGPNLVESAVPEMIPPT 186
            R L       ++  ACG    A L   G +  +G G    LG G +L + + P ++   
Sbjct: 382 SRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEAL 440

Query: 187 LFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMP 246
           L          ++ ++ CG S   AL+ + ELF WG+   G LG+G  E    P +V MP
Sbjct: 441 L--------GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492

Query: 247 --GEPVDVACGVDHMVTL 262
              E   V CG+D  + L
Sbjct: 493 PGQEAQRVVCGIDSSMIL 510



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 42/154 (27%), Positives = 64/154 (41%), Gaps = 19/154 (12%)

Query: 33  GQVVQ-VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP------------TKL 79
           GQ  Q V CG D S+ LT  G+  +CG     + GL H ++   P            T L
Sbjct: 494 GQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLL 553

Query: 80  GG---DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 136
           G    D   +  I + T      AV+A G  + +G++++ QL + T        +     
Sbjct: 554 GSAPLDQEPLLSIDLGTAHSA--AVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE 611

Query: 137 GVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 170
           G+ K+   ACG      +  E  V+ WG G  G+
Sbjct: 612 GI-KMAMVACGDAFTVAIGAESEVYSWGKGARGR 644



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 60/241 (24%), Positives = 96/241 (39%), Gaps = 31/241 (12%)

Query: 34  QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 93
           ++VQVACG  H L L+ + E+++ G G  G+ GLG     S P ++     G    +V  
Sbjct: 444 EMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP-PGQEAQRVVC 502

Query: 94  YGDCCLAVSADGGLFGWGNSEYLQLA------SVTDSTQVNVPRCLHFSGVGK------- 140
             D  + ++  G     G++ + +L                V   L F+ +G        
Sbjct: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562

Query: 141 VRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEI 197
           +     G    A +   G  + +G   +G LG        A     P  + GL      I
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-----PCKVQGL----EGI 613

Query: 198 QVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV----TMPGEPVDVA 253
           +++ + CG +   A+  + E++ WGK  RG LG  R ED   P  V    T P     V+
Sbjct: 614 KMAMVACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLDETHPYTVTSVS 672

Query: 254 C 254
           C
Sbjct: 673 C 673



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G+N +GQ G           S    ++Q  +G ++  VACG   ++ +  + EVYS G G
Sbjct: 586 GSNQHGQLGTNTRRG-----SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKG 640

Query: 61  ADGQTG 66
           A G+ G
Sbjct: 641 ARGRLG 646


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 57/202 (28%), Positives = 86/202 (42%), Gaps = 18/202 (8%)

Query: 74  SSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE-----YLQLASVTDSTQVN 128
           S+P KL    +G +  QV         V+ +  L+ W N +     + QL    D     
Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYR 415

Query: 129 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPP 185
            P+ +       +RQ +CG      +  EG ++ +G   YG +G    + + A PE++ P
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG----VDKVAGPEVLEP 471

Query: 186 TLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 245
                   NP  QVS   CG +    LT   E++ WG    G LG+   ED Y P +V +
Sbjct: 472 MQLNFFLSNPVEQVS---CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV 528

Query: 246 PGEPVDVA--CGVDHMVTLAKS 265
           P   + VA  CG D    L +S
Sbjct: 529 PKALIIVAVQCGCDGTFLLTQS 550



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 67/248 (27%), Positives = 109/248 (43%), Gaps = 31/248 (12%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVV-QVACGQDHSLFLTDKGEVYSCG-- 58
           G   +GQ G    +   Y +   V ++Q   G+ + QV+CG D ++ +TD+G++Y+ G  
Sbjct: 399 GTKLHGQLGHG--DKASYRQPKHVEKLQ---GKAIRQVSCGDDFTVCVTDEGQLYAFGSD 453

Query: 59  -WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAV-SADGGLFGWGNSEY- 115
            +G  G   +    +   P +L   L+  N ++  + GD  + V + +  ++ WG  EY 
Sbjct: 454 YYGCMGVDKVAGPEVL-EPMQLNFFLS--NPVEQVSCGDNHVVVLTRNKEVYSWGCGEYG 510

Query: 116 -LQLASVTD---STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK- 170
            L L S  D     +V+VP+ L    V       CG  G  +L   G V   G     K 
Sbjct: 511 RLGLDSEEDYYTPQKVDVPKALIIVAV------QCGCDGTFLLTQSGKVLACGLNEFNKL 564

Query: 171 GPN------LVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKN 224
           G N      +   A  E+   T F L +     ++  I  G +  AA+  +G L  +G N
Sbjct: 565 GLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCN 624

Query: 225 IRGCLGIG 232
             G LG+G
Sbjct: 625 KCGQLGVG 632



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 33/117 (28%), Positives = 57/117 (48%), Gaps = 6/117 (5%)

Query: 8   QCGRKVVENEIYSE-----SHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGAD 62
           QC   ++ +E Y E     S  + +   F  ++  +A G+ H+  + ++G + + G    
Sbjct: 568 QCMSGIINHEAYHEVPYTTSFTLAKQLSFY-KIRTIAPGKTHTAAIDERGRLLTFGCNKC 626

Query: 63  GQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
           GQ G+G+Y        LGG L G  VI+V+   +  +A + D  +F WGN    +LA
Sbjct: 627 GQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLA 683



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 56/212 (26%), Positives = 85/212 (40%), Gaps = 24/212 (11%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           V QV+CG +H + LT   EVYS G G  G+ GL       +P K+    A + ++ V   
Sbjct: 482 VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI-IVAVQCG 540

Query: 95  GDCCLAVSADGGLFGWGNSEYLQL-------ASVTDSTQVNVPRCLHFS-----GVGKVR 142
            D    ++  G +   G +E+ +L         +       VP    F+        K+R
Sbjct: 541 CDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIR 600

Query: 143 QAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQV 199
             A G T  A ++  G +  +G    G LG G N  +     ++   L G        QV
Sbjct: 601 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGK-------QV 652

Query: 200 SRIRCGLSRFAALTNKGELFVWGKNIRGCLGI 231
            R+ CG     A T+   +F WG    G L +
Sbjct: 653 IRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 10/34 (29%), Positives = 22/34 (64%)

Query: 34  QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGL 67
           QV++V+CG + ++  TD   +++ G G +G+  +
Sbjct: 651 QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684


>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
           sapiens]
          Length = 438

 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)

Query: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 109 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 163

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 164 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 223

Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 224 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 283

Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
             Y  LG  P      +P+ +                                       
Sbjct: 284 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 342

Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
            GL E   E  +          S + CG S   A+T  G +F WG      LG G+ ED 
Sbjct: 343 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 402

Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
           + P  V M G+ ++      V+ G  H V L K
Sbjct: 403 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 433



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 86  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 144

Query: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 145 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 194

Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 195 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 254

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 255 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 304


>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
           sapiens]
          Length = 452

 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)

Query: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 123 GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 177

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 178 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 237

Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 238 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 297

Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
             Y  LG  P      +P+ +                                       
Sbjct: 298 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 356

Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
            GL E   E  +          S + CG S   A+T  G +F WG      LG G+ ED 
Sbjct: 357 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 416

Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
           + P  V M G+ ++      V+ G  H V L K
Sbjct: 417 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 447



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 158

Query: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 159 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 208

Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 209 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 268

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 269 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 318


>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
           sapiens]
          Length = 421

 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)

Query: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 92  GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206

Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266

Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
             Y  LG  P      +P+ +                                       
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325

Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
            GL E   E  +          S + CG S   A+T  G +F WG      LG G+ ED 
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385

Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
           + P  V M G+ ++      V+ G  H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127

Query: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177

Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287


>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)

Query: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 92  GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206

Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266

Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
             Y  LG  P      +P+ +                                       
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325

Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
            GL E   E  +          S + CG S   A+T  G +F WG      LG G+ ED 
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385

Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
           + P  V M G+ ++      V+ G  H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127

Query: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177

Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287


>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)

Query: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 92  GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206

Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266

Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
             Y  LG  P      +P+ +                                       
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325

Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
            GL E   E  +          S + CG S   A+T  G +F WG      LG G+ ED 
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385

Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
           + P  V M G+ ++      V+ G  H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127

Query: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177

Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287


>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 83/333 (24%), Positives = 120/333 (36%), Gaps = 78/333 (23%)

Query: 2   GNNSYGQCGRKV-VENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
           G N  G  GR   VE      S  V    +   +VVQV+ G  H+  LTD G V+  G  
Sbjct: 92  GCNDEGALGRDTSVEG-----SEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF 146

Query: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
            D    +G                 V V++VA+  D  + ++ADG L+  G  E  QL  
Sbjct: 147 RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGR 206

Query: 121 VTD----------STQVNVPRCLHFSGVG-----KVRQAACGGTGCAVLNGEGHVFVWG- 164
           V +            ++ VP+C+     G     + + A CG      ++ EGHV+ +G 
Sbjct: 207 VPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGL 266

Query: 165 --YGILGKGPNLVESAVPEMIPP-----------------------------------TL 187
             Y  LG  P      +P+ +                                       
Sbjct: 267 SNYHQLGT-PGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGR 325

Query: 188 FGLTEFNPEIQV----------SRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQ 237
            GL E   E  +          S + CG S   A+T  G +F WG      LG G+ ED 
Sbjct: 326 LGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDA 385

Query: 238 YFPWRVTMPGEPVD------VACGVDHMVTLAK 264
           + P  V M G+ ++      V+ G  H V L K
Sbjct: 386 WSP--VEMMGKQLENRVVLSVSSGGQHTVLLVK 416



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 52/230 (22%), Positives = 91/230 (39%), Gaps = 31/230 (13%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           VVQ   G  H++ L+  G+VYS G   +G  G    ++  S    G       V+QV+  
Sbjct: 69  VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALG-RDTSVEGSEMVPGKVELQEKVVQVSAG 127

Query: 95  GDCCLAVSADGGLFGWGN----------SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQA 144
                A++ DG +F WG+           E ++ + V    Q++VP          V + 
Sbjct: 128 DSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVP----------VVKV 177

Query: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLV-----ESAVPEMIPPTLFGLTE--FN 194
           A G     +L  +G ++  G    G LG+ P L         +  ++ P    L      
Sbjct: 178 ASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSR 237

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 244
             ++     CG     A++++G ++ +G +    LG    E  + P  +T
Sbjct: 238 GHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287


>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
          Length = 1353

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 40/129 (31%), Positives = 61/129 (47%), Gaps = 8/129 (6%)

Query: 35  VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 94
           + QV   + HS+FL+ KG+VY+CG G  G+ G G       P  + G L G N  QVA  
Sbjct: 179 IKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEG-LNGHNCSQVAAA 237

Query: 95  GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 154
            D  + ++ DG ++ +G + + QL  +   +  NVPR +         +   G T   V 
Sbjct: 238 KDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQ-------AKYLKGRTIIGVA 290

Query: 155 NGEGHVFVW 163
            G  H  +W
Sbjct: 291 AGRFHTVLW 299


>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 58/194 (29%), Positives = 78/194 (40%), Gaps = 22/194 (11%)

Query: 37  QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 96
           Q+  G +H+L L   G+V+S G G  GQ G G       P  L   L G+ + +VA  G 
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220

Query: 97  CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 156
             + VS  G ++ WG +E  QLA  T        R L   G    R+A         LN 
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265

Query: 157 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
           +G       G     P    +  P    P L  L   +  ++ S   CG    A +T  G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319

Query: 217 ELFVWGKNIRGCLG 230
           EL+ WG    G LG
Sbjct: 320 ELYTWGWGKYGQLG 333



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 40/170 (23%), Positives = 67/170 (39%), Gaps = 22/170 (12%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G   +GQ G   +E E+  E   +  +Q     + +VA G  HS+ +++ G++Y  GW  
Sbjct: 183 GGGRHGQLGHGTLEAEL--EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNE 238

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLAS 120
            GQ  L   N+            G  V + AT   +    V   GG      + ++ +  
Sbjct: 239 SGQLALPTRNLAED---------GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP 289

Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 170
                    P  L         +A+CG    AV+   G ++ WG+G  G+
Sbjct: 290 --------FPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)

Query: 36  VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 74
           V+ +CG  H+  +T  GE+Y+ GWG  GQ  LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339



 Score = 31.2 bits (69), Expect = 0.99
 Identities = 15/46 (32%), Positives = 22/46 (47%)

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           PE++  ++  G      L   G++F WG    G LG G LE +  P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201


>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 58/194 (29%), Positives = 78/194 (40%), Gaps = 22/194 (11%)

Query: 37  QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 96
           Q+  G +H+L L   G+V+S G G  GQ G G       P  L   L G+ + +VA  G 
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220

Query: 97  CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 156
             + VS  G ++ WG +E  QLA  T        R L   G    R+A         LN 
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265

Query: 157 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
           +G       G     P    +  P    P L  L   +  ++ S   CG    A +T  G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319

Query: 217 ELFVWGKNIRGCLG 230
           EL+ WG    G LG
Sbjct: 320 ELYTWGWGKYGQLG 333



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 40/170 (23%), Positives = 67/170 (39%), Gaps = 22/170 (12%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
           G   +GQ G   +E E+  E   +  +Q     + +VA G  HS+ +++ G++Y  GW  
Sbjct: 183 GGGRHGQLGHGTLEAEL--EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNE 238

Query: 62  DGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLAS 120
            GQ  L   N+            G  V + AT   +    V   GG      + ++ +  
Sbjct: 239 SGQLALPTRNLAED---------GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP 289

Query: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 170
                    P  L         +A+CG    AV+   G ++ WG+G  G+
Sbjct: 290 --------FPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)

Query: 36  VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 74
           V+ +CG  H+  +T  GE+Y+ GWG  GQ  LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339



 Score = 31.2 bits (69), Expect = 0.99
 Identities = 15/46 (32%), Positives = 22/46 (47%)

Query: 195 PEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
           PE++  ++  G      L   G++F WG    G LG G LE +  P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 30/190 (15%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
           G+  +G+ GR   E       +    ++  +GQ V Q+ CG    L LT  G V++  WG
Sbjct: 29  GDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT--WG 81

Query: 61  ADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQL 118
                 LGH +      P  + G L G  ++ VA     CLAV   G ++ WG++++ Q 
Sbjct: 82  KGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 140

Query: 119 ASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESA 178
            + T +T    P  +      K+   ACG +         H   W           V+ A
Sbjct: 141 GNGT-TTVNRKPTLVQGLEGQKIMCVACGSS---------HSVAW---------TTVDVA 181

Query: 179 VPEMIPPTLF 188
            P +  P LF
Sbjct: 182 TPSVHEPVLF 191



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 40/156 (25%), Positives = 63/156 (40%), Gaps = 9/156 (5%)

Query: 107 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG 166
           +F WG+ ++ +L     S   N+P+ +       V Q  CG      L   G V+ WG G
Sbjct: 25  VFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83

Query: 167 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIR 226
              +  +   S V    P  + GL       ++  +  G     A+ + G+++ WG N  
Sbjct: 84  DYFRLGH--RSDVHVRKPQVVEGLRGK----KIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137

Query: 227 GCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 260
           G  G G       P  V  + G+ +  VACG  H V
Sbjct: 138 GQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173



 Score = 28.9 bits (63), Expect = 4.9
 Identities = 24/68 (35%), Positives = 28/68 (41%), Gaps = 8/68 (11%)

Query: 157 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNK 215
           E  VF WG G  GK G    E      IP  +  L        V +I CG     ALT  
Sbjct: 22  ESLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 74

Query: 216 GELFVWGK 223
           G ++ WGK
Sbjct: 75  GVVWTWGK 82


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1102

 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 47/189 (24%), Positives = 77/189 (40%), Gaps = 28/189 (14%)

Query: 2   GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWG 60
           G+  +G+ GR   E       +    ++  +GQ V Q+ CG    L LT  G V++  WG
Sbjct: 731 GDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT--WG 783

Query: 61  ADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 119
                 LGH + +     ++   L G  ++ VA     CLAV   G ++ WG++++ Q  
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 843

Query: 120 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAV 179
           + T +T    P  +      K+   ACG +         H   W           ++ A 
Sbjct: 844 NGT-TTVNRKPMLVQGLEGQKIMCVACGSS---------HSVAW---------TTMDVAT 884

Query: 180 PEMIPPTLF 188
           P +  P LF
Sbjct: 885 PSVHEPVLF 893



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 40/159 (25%), Positives = 65/159 (40%), Gaps = 10/159 (6%)

Query: 105 GGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 163
           GGL F WG+ ++ +L     S   N+P+ +       V Q  CG      L   G V+ W
Sbjct: 724 GGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 782

Query: 164 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
           G G   +  +  +  V ++       + E     ++  +  G     A+ + G+++ WG 
Sbjct: 783 GKGDYFRLGHRSDVHVRKL------QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGD 836

Query: 224 NIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 260
           N  G  G G       P  V  + G+ +  VACG  H V
Sbjct: 837 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 875



 Score = 29.6 bits (65), Expect = 2.9
 Identities = 50/188 (26%), Positives = 64/188 (34%), Gaps = 30/188 (15%)

Query: 50  DKGEVYSCGWGADGQTGLGHYN--------ITSSPTKLGGDLAGV--NVIQVATYGDCC- 98
           D+GE  + G  ADG     +YN           +P    G  A     +     +GD C 
Sbjct: 613 DEGE--AAGAAADGVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKHGDLCE 670

Query: 99  --LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 156
             L  SA G    W +        +     V       +   GKV       T C +   
Sbjct: 671 VSLTSSAQGEAT-WPHPVLFHFGEIIQDKSVGN---WEYISTGKVSDNYALLTKCEM--- 723

Query: 157 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNK 215
            G VF WG G  GK G    E      IP  +  L        V +I CG     ALT  
Sbjct: 724 GGLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 776

Query: 216 GELFVWGK 223
           G ++ WGK
Sbjct: 777 GVVWTWGK 784


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.140    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,763,109
Number of Sequences: 37866
Number of extensions: 478128
Number of successful extensions: 1311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 863
Number of HSP's gapped (non-prelim): 182
length of query: 267
length of database: 18,247,518
effective HSP length: 100
effective length of query: 167
effective length of database: 14,460,918
effective search space: 2414973306
effective search space used: 2414973306
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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