Guide to the Human Genome
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Name: IBTK Sequence: fasta or formatted (1353aa) NCBI GI: 57863304
Description:

inhibitor of Bruton's tyrosine kinase

Referenced in:

Ran and Rag
Non-Receptor Tyrosine Kinase Pathways

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             5.6         76           3
 C cysteine            2.5         34           1
 D aspartate           5.6         76           2
 E glutamate           6.0         81           3
 F phenylalanine       4.2         57           2
 G glycine             6.0         81           2
 H histidine           3.4         46           2
 I isoleucine          5.0         67           2
 K lysine              8.1        109           3
 L leucine             9.5        129           2
 M methionine          1.9         26           1
 N asparagine          4.1         55           2
 P proline             4.5         61           3
 Q glutamine           3.7         50           2
 R arginine            3.8         51           2
 S serine             10.3        139           4
 T threonine           4.9         66           2
 V valine              7.5        101           2
 W tryptophan          1.0         14           1
 Y tyrosine            2.5         34           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   inhibitor of Bruton's tyrosine kinase 
HERC2                 0.025   hect domain and RLD 2 
HERC3                 0.024   hect domain and RLD 3 
HERC1                 0.022   guanine nucleotide exchange factor p532 
HERC4                 0.022   hect domain and RLD 4 isoform b 
HERC4                 0.022   hect domain and RLD 4 isoform a 
HERC5                 0.021   hect domain and RLD 5 
RCC2                  0.020   regulator of chromosome condensation 2 
RCC2                  0.020   regulator of chromosome condensation 2 
RCBTB2                0.018   regulator of chromosome condensation and BTB domain c...
KLHL11                0.018   kelch-like 11 
SERGEF                0.018   deafness locus associated putative guanine nucleotide...
LOC390561             0.017   PREDICTED: similar to hect domain and RLD 2 
SPOP                  0.017   speckle-type POZ protein 
SPOP                  0.017   speckle-type POZ protein 
SPOP                  0.017   speckle-type POZ protein 
SPOP                  0.017   speckle-type POZ protein 
SPOP                  0.017   speckle-type POZ protein 
SPOP                  0.017   speckle-type POZ protein 
LOC100290629          0.017   PREDICTED: hypothetical protein XP_002347563 
NEK8                  0.017   NIMA-related kinase 8 
LOC390561             0.016   PREDICTED: similar to hect domain and RLD 2 
KLHL10                0.016   kelch-like 10 
MYCBP2                0.016   MYC binding protein 2 
NEK9                  0.016   NIMA-related kinase 9 
KBTBD6                0.016   kelch repeat and BTB (POZ) domain-containing 6 [Homo...
KLHL6                 0.015   kelch-like 6 
SPOPL                 0.015   speckle-type POZ protein-like 
RPGR                  0.014   retinitis pigmentosa GTPase regulator isoform A [Homo...
RPGR                  0.014   retinitis pigmentosa GTPase regulator isoform C [Hom...
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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