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Search of human proteins with 169165926
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169165926 PREDICTED: similar to ataxia telangiectasia and
Rad3 related protein, partial [Homo sapiens]
(386 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom... 801 0.0
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad... 801 0.0
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens] 223 2e-58
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens] 223 2e-58
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa... 223 2e-58
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 197 1e-50
gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad... 187 1e-47
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens] 186 3e-47
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide... 159 5e-39
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid... 142 7e-34
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated... 142 7e-34
gi|4507691 transformation/transcription domain-associated protei... 92 6e-19
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi... 62 7e-10
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept... 54 2e-07
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa... 49 6e-06
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid... 49 1e-05
gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo... 48 1e-05
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa... 48 1e-05
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ... 44 2e-04
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 44 2e-04
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid... 43 4e-04
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 42 0.001
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase... 41 0.002
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide... 38 0.014
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 31 1.7
gi|157364939 phosphodiesterase 6C [Homo sapiens] 30 3.7
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 29 8.2
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 29 8.2
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 29 8.2
gi|31563526 solute carrier family 24 (sodium/potassium/calcium e... 29 8.2
>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
sapiens]
Length = 2644
Score = 801 bits (2068), Expect = 0.0
Identities = 386/386 (100%), Positives = 386/386 (100%)
Query: 1 LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD 60
LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD
Sbjct: 2259 LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD 2318
Query: 61 GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIE 120
GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIE
Sbjct: 2319 GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIE 2378
Query: 121 WVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHE 180
WVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHE
Sbjct: 2379 WVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHE 2438
Query: 181 WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCL 240
WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCL
Sbjct: 2439 WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCL 2498
Query: 241 FNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFL 300
FNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFL
Sbjct: 2499 FNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFL 2558
Query: 301 HDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEG 360
HDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEG
Sbjct: 2559 HDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEG 2618
Query: 361 HVHYLIQEATDENLLCQMYLGWTPYM 386
HVHYLIQEATDENLLCQMYLGWTPYM
Sbjct: 2619 HVHYLIQEATDENLLCQMYLGWTPYM 2644
>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 386
Score = 801 bits (2068), Expect = 0.0
Identities = 386/386 (100%), Positives = 386/386 (100%)
Query: 1 LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD 60
LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD
Sbjct: 1 LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD 60
Query: 61 GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIE 120
GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIE
Sbjct: 61 GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIE 120
Query: 121 WVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHE 180
WVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHE
Sbjct: 121 WVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHE 180
Query: 181 WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCL 240
WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCL
Sbjct: 181 WFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCL 240
Query: 241 FNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFL 300
FNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFL
Sbjct: 241 FNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFL 300
Query: 301 HDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEG 360
HDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEG
Sbjct: 301 HDPLVEWSKPVKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEG 360
Query: 361 HVHYLIQEATDENLLCQMYLGWTPYM 386
HVHYLIQEATDENLLCQMYLGWTPYM
Sbjct: 361 HVHYLIQEATDENLLCQMYLGWTPYM 386
>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
Length = 1708
Score = 223 bits (569), Expect = 2e-58
Identities = 133/408 (32%), Positives = 210/408 (51%), Gaps = 35/408 (8%)
Query: 4 LQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKF 63
L+ V++PT+ H G+ I F + + PK I GSDGK
Sbjct: 1311 LEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKE 1363
Query: 64 YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVN 123
+ K +DDLR+D + + + N L+++ E+R+R+L I TY V+PL+ G++EW
Sbjct: 1364 RRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT 1423
Query: 124 NTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPKSAALSEKLKVFREFLLPRHP 175
T + L E G + + ++ M + + EK +VF + +
Sbjct: 1424 GTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD-VCQNFQ 1480
Query: 176 PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHV 235
P+F + + F DP W+ R AY RS A S+VGYILGLGDRH +NIL + + E VH+
Sbjct: 1481 PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 1540
Query: 236 DFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSV 295
D F +G+ PE VPFRLT ++V+GMG G EG+FRR CE TM +MR+ +E L+++
Sbjct: 1541 DLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTI 1600
Query: 296 LKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVNEKAKTHVLDIEQRLQGVI-- 345
++ L+DPL +W+ P+K + L+ T +++ K ++ DI+Q V
Sbjct: 1601 VEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAER 1660
Query: 346 -------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
K + G LS+ G V+ LIQ+A D L +++ GW ++
Sbjct: 1661 VLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 1708
>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
Length = 3056
Score = 223 bits (569), Expect = 2e-58
Identities = 133/408 (32%), Positives = 210/408 (51%), Gaps = 35/408 (8%)
Query: 4 LQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKF 63
L+ V++PT+ H G+ I F + + PK I GSDGK
Sbjct: 2659 LEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKE 2711
Query: 64 YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVN 123
+ K +DDLR+D + + + N L+++ E+R+R+L I TY V+PL+ G++EW
Sbjct: 2712 RRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT 2771
Query: 124 NTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPKSAALSEKLKVFREFLLPRHP 175
T + L E G + + ++ M + + EK +VF + +
Sbjct: 2772 GTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD-VCQNFQ 2828
Query: 176 PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHV 235
P+F + + F DP W+ R AY RS A S+VGYILGLGDRH +NIL + + E VH+
Sbjct: 2829 PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2888
Query: 236 DFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSV 295
D F +G+ PE VPFRLT ++V+GMG G EG+FRR CE TM +MR+ +E L+++
Sbjct: 2889 DLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTI 2948
Query: 296 LKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVNEKAKTHVLDIEQRLQGVI-- 345
++ L+DPL +W+ P+K + L+ T +++ K ++ DI+Q V
Sbjct: 2949 VEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAER 3008
Query: 346 -------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
K + G LS+ G V+ LIQ+A D L +++ GW ++
Sbjct: 3009 VLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 3056
>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
[Homo sapiens]
Length = 2934
Score = 223 bits (569), Expect = 2e-58
Identities = 133/408 (32%), Positives = 210/408 (51%), Gaps = 35/408 (8%)
Query: 4 LQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKF 63
L+ V++PT+ H G+ I F + + PK I GSDGK
Sbjct: 2537 LEDVVVPTMEI-------KVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKE 2589
Query: 64 YIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVN 123
+ K +DDLR+D + + + N L+++ E+R+R+L I TY V+PL+ G++EW
Sbjct: 2590 RRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCT 2649
Query: 124 NTAGLRPILTKLYKEKGVYMTGKE--------LRQCMLPKSAALSEKLKVFREFLLPRHP 175
T + L E G + + ++ M + + EK +VF + +
Sbjct: 2650 GTVPIGEFLVN--NEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMD-VCQNFQ 2706
Query: 176 PIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHV 235
P+F + + F DP W+ R AY RS A S+VGYILGLGDRH +NIL + + E VH+
Sbjct: 2707 PVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHI 2766
Query: 236 DFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSV 295
D F +G+ PE VPFRLT ++V+GMG G EG+FRR CE TM +MR+ +E L+++
Sbjct: 2767 DLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTI 2826
Query: 296 LKTFLHDPLVEWS-KPVKG-------HSKAPLNETGEVVNEKAKTHVLDIEQRLQGVI-- 345
++ L+DPL +W+ P+K + L+ T +++ K ++ DI+Q V
Sbjct: 2827 VEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFDKVAER 2886
Query: 346 -------KTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
K + G LS+ G V+ LIQ+A D L +++ GW ++
Sbjct: 2887 VLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV 2934
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 197 bits (502), Expect = 1e-50
Identities = 124/390 (31%), Positives = 198/390 (50%), Gaps = 47/390 (12%)
Query: 42 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRE 101
++++ S Q+P+K++L GS+G ++ + K +DLR+D R+M+ L+N L D S R+
Sbjct: 2160 LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN 2219
Query: 102 LHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKE----LRQCMLPKSA 157
L I+ YAVIPL+ G+I WV + L ++ + Y+EK + E LR
Sbjct: 2220 LSIQRYAVIPLSTNSGLIGWVPHCDTLHALI-RDYREKKKILLNIEHRIMLRMAPDYDHL 2278
Query: 158 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 217
L +K++VF + + P W+ R+ Y RS AVMSMVGYILGLGD
Sbjct: 2279 TLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGD 2338
Query: 218 RHGENILFDSLTGECVHVDFNCLFNKGETFE-VPEIVPFRLTHNMVNGMGPMGTEGLFRR 276
RH N++ D L+G+ +H+DF F T E PE +PFRLT + N M G +G +R
Sbjct: 2339 RHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRI 2398
Query: 277 ACEVTMRLMRDQREPLMSVLKTFLHDPLVEW---SKPVKGHSKAPLN------------- 320
C M ++R+ ++ +M+VL+ F++DPL+ W KG+ ++
Sbjct: 2399 TCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEIL 2458
Query: 321 ---ETGEVVNEKAKTHVLDI----------------EQRLQGVIKTRNRVTGL------P 355
E GE ++K T V + ++ +Q + + R+++TG
Sbjct: 2459 DGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDT 2518
Query: 356 LSIEGHVHYLIQEATDENLLCQMYLGWTPY 385
L + V LI++AT LCQ Y+GW P+
Sbjct: 2519 LDVPTQVELLIKQATSHENLCQCYIGWCPF 2548
>gi|169218238 PREDICTED: similar to ataxia telangiectasia and Rad3
related protein, partial [Homo sapiens]
Length = 2105
Score = 187 bits (475), Expect = 1e-47
Identities = 89/89 (100%), Positives = 89/89 (100%)
Query: 1 LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD 60
LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD
Sbjct: 2017 LIPLQSVMIPTLPSILGTHANHASHEPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSD 2076
Query: 61 GKFYIMMCKPKDDLRKDCRLMEFNSLINK 89
GKFYIMMCKPKDDLRKDCRLMEFNSLINK
Sbjct: 2077 GKFYIMMCKPKDDLRKDCRLMEFNSLINK 2105
>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
Length = 3661
Score = 186 bits (472), Expect = 3e-47
Identities = 105/301 (34%), Positives = 152/301 (50%), Gaps = 36/301 (11%)
Query: 42 VEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRE 101
+ IL + KPKK+ GSDGK Y + K +DL D R+M+F S++N
Sbjct: 2128 ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPR 2187
Query: 102 LHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSE 161
H R Y+V PL G+I+WV+ L + + + + K P++ +
Sbjct: 2188 FHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAALQAQKAQDSYQTPQNPGIVP 2247
Query: 162 K-------------------------------LKVFREFLLPRHPPIF---HEWFLRTFP 187
+ +K E L+ PP W T P
Sbjct: 2248 RPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEELMEATPPNLLAKELWSSCTTP 2307
Query: 188 DPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETF 247
D W+ +Y RSTAVMSMVGYI+GLGDRH +N+L D TGE VH+D+N F KG++
Sbjct: 2308 D--EWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEKGKSL 2365
Query: 248 EVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW 307
VPE VPFR+T N+ +G G EG+FR +CE + +MR RE L+++L+ F++DPLV+W
Sbjct: 2366 RVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMRRGRETLLTLLEAFVYDPLVDW 2425
Query: 308 S 308
+
Sbjct: 2426 T 2426
Score = 38.9 bits (89), Expect = 0.008
Identities = 19/66 (28%), Positives = 41/66 (62%), Gaps = 1/66 (1%)
Query: 321 ETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYL 380
+TG+ V E+ ++ + + +R++ ++ R+ +S+ V Y+I+EAT+ + L Q+Y
Sbjct: 3597 KTGKAVQER-NSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYE 3655
Query: 381 GWTPYM 386
GWT ++
Sbjct: 3656 GWTAWV 3661
>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
isoform 1 [Homo sapiens]
Length = 4128
Score = 159 bits (401), Expect = 5e-39
Identities = 116/431 (26%), Positives = 188/431 (43%), Gaps = 82/431 (19%)
Query: 26 EPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNS 85
+P P + IAGFD+ V ++ASL++PK+I ++G D + + + K +DLR+D R+ +
Sbjct: 3710 KPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQ 3769
Query: 86 LINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPIL--TKLYKEKGVYM 143
++N L +D+ +R L +RTY+V+P+ G+IEW+ NT L+ +L T +EK Y+
Sbjct: 3770 VMNGILAQDSACSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYL 3829
Query: 144 TGKELRQC-------------------MLPKSAALSEKLKVFREFLLPRHPPIFHEWFLR 184
+ C ++ K A +E + FR+ + F+R
Sbjct: 3830 SDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVR 3889
Query: 185 TFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKG 244
P ++ + RS + S A++ + +ILG+GDRH N + TG + +DF F
Sbjct: 3890 MSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSA 3949
Query: 245 ETF-EVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDP 303
F VPE++PFRLT +N M PM GL +R R L + + F+ +P
Sbjct: 3950 TQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEP 4009
Query: 304 LVEW----SKPVK--------------------------------------------GHS 315
+W K +K GH
Sbjct: 4010 SFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHE 4069
Query: 316 KAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLL 375
KAP V +K H + ++ G LS E V L+ +ATD N+L
Sbjct: 4070 KAPAFRDYVAVARGSKDHNIRAQEPESG------------LSEETQVKCLMDQATDPNIL 4117
Query: 376 CQMYLGWTPYM 386
+ + GW P+M
Sbjct: 4118 GRTWEGWEPWM 4128
>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
isoform 2 [Homo sapiens]
Length = 4097
Score = 142 bits (357), Expect = 7e-34
Identities = 109/416 (26%), Positives = 178/416 (42%), Gaps = 83/416 (19%)
Query: 26 EPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNS 85
+P P + IAGFD+ V ++ASL++PK+I ++G D + + + K +DLR+D R+ +
Sbjct: 3710 KPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQ 3769
Query: 86 LINKCLRKDAESRRRELHIRTYAVIPLNDE------CGIIEWVNNTAGLRPILTKLYKEK 139
++N L +D+ +R L +RTY+V+P+ C +W+ +G +
Sbjct: 3770 VMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDV-------- 3821
Query: 140 GVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAY 199
G YM ++ K A +E + FR+ + F+R P ++ + RS +
Sbjct: 3822 GAYM--------LMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHF 3873
Query: 200 CRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETF-EVPEIVPFRLT 258
S A++ + +ILG+GDRH N + TG + +DF F F VPE++PFRLT
Sbjct: 3874 ASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLT 3933
Query: 259 HNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW----SKPVK-- 312
+N M PM GL +R R L + + F+ +P +W K +K
Sbjct: 3934 RQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKG 3993
Query: 313 ------------------------------------------GHSKAPLNETGEVVNEKA 330
GH KAP V +
Sbjct: 3994 GSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGS 4053
Query: 331 KTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
K H + ++ G LS E V L+ +ATD N+L + + GW P+M
Sbjct: 4054 KDHNIRAQEPESG------------LSEETQVKCLMDQATDPNILGRTWEGWEPWM 4097
>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
catalytic polypeptide [Homo sapiens]
Length = 4096
Score = 142 bits (357), Expect = 7e-34
Identities = 109/416 (26%), Positives = 178/416 (42%), Gaps = 83/416 (19%)
Query: 26 EPFPGHWAYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNS 85
+P P + IAGFD+ V ++ASL++PK+I ++G D + + + K +DLR+D R+ +
Sbjct: 3709 KPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQ 3768
Query: 86 LINKCLRKDAESRRRELHIRTYAVIPLNDE------CGIIEWVNNTAGLRPILTKLYKEK 139
++N L +D+ +R L +RTY+V+P+ C +W+ +G +
Sbjct: 3769 VMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDV-------- 3820
Query: 140 GVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAY 199
G YM ++ K A +E + FR+ + F+R P ++ + RS +
Sbjct: 3821 GAYM--------LMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHF 3872
Query: 200 CRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETF-EVPEIVPFRLT 258
S A++ + +ILG+GDRH N + TG + +DF F F VPE++PFRLT
Sbjct: 3873 ASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLT 3932
Query: 259 HNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEW----SKPVK-- 312
+N M PM GL +R R L + + F+ +P +W K +K
Sbjct: 3933 RQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKG 3992
Query: 313 ------------------------------------------GHSKAPLNETGEVVNEKA 330
GH KAP V +
Sbjct: 3993 GSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGS 4052
Query: 331 KTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM 386
K H + ++ G LS E V L+ +ATD N+L + + GW P+M
Sbjct: 4053 KDHNIRAQEPESG------------LSEETQVKCLMDQATDPNILGRTWEGWEPWM 4096
>gi|4507691 transformation/transcription domain-associated protein
[Homo sapiens]
Length = 3830
Score = 92.4 bits (228), Expect = 6e-19
Identities = 87/376 (23%), Positives = 162/376 (43%), Gaps = 19/376 (5%)
Query: 27 PFPGHWAY-IAGFDDMVEILASLQKP-KKISLKGSDGKFY---IMMCKPKDDLRKDCRLM 81
P P H+ IA F VEI+ +++ ++G +GK Y +M + R++ R++
Sbjct: 3458 PKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVL 3517
Query: 82 EFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGV 141
+ L+N CL K E+ +R L V+ ++ + ++E ++ L I + +KG+
Sbjct: 3518 QLLRLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGI 3577
Query: 142 --------YMTGKELRQCMLPKSA--ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTS 191
Y Q +++ L + LK + ++PR + EW L TFP+ T
Sbjct: 3578 EHDNPISRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRS--MLKEWALHTFPNATD 3635
Query: 192 WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGE-TFEVP 250
+++ R + A++ ++L L + E + TG+ F N +
Sbjct: 3636 YWTFRKMFTIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDAN 3695
Query: 251 EIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKP 310
VPFRLT N+ + +G G + R + +LKT L D ++ W K
Sbjct: 3696 RPVPFRLTPNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWHKK 3755
Query: 311 VKGHSKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEAT 370
+ + +PL+ G+ N ++ ++ + Q+ I TR E V+ L+ A
Sbjct: 3756 TQEDTSSPLSAAGQPENMDSQ-QLVSLVQKAVTAIMTRLHNLAQFEGGESKVNTLVAAAN 3814
Query: 371 DENLLCQMYLGWTPYM 386
+ LC+M W P++
Sbjct: 3815 SLDNLCRMDPAWHPWL 3830
>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo
sapiens]
Length = 887
Score = 62.4 bits (150), Expect = 7e-10
Identities = 59/239 (24%), Positives = 102/239 (42%), Gaps = 51/239 (21%)
Query: 44 ILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELH 103
+ S P ++ K DG Y ++ K DDLR+D +++ SL++K LRK+ +L
Sbjct: 611 LFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKE----NLDLK 666
Query: 104 IRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKL 163
+ Y V+ + + G ++++ + P+ L E +
Sbjct: 667 LTPYKVLATSTKHGFMQFIQSV----PVAEVLDTEGSIQ--------------------- 701
Query: 164 KVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSR--SAYCRSTAVMSMVGYILGLGDRHGE 221
FR++ + P + S+ Y +S A ++ YILG+GDRH +
Sbjct: 702 NFFRKYAPSENGP--------------NGISAEVMDTYVKSCAGYCVITYILGVGDRHLD 747
Query: 222 NILFDSLTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGL--FRRAC 278
N+L + TG+ H+DF + + P P +L MV GMG +E FR+ C
Sbjct: 748 NLLL-TKTGKLFHIDFGYILGRDPK---PLPPPMKLNKEMVEGMGGTQSEQYQEFRKQC 802
>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
[Homo sapiens]
Length = 1102
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/234 (22%), Positives = 98/234 (41%), Gaps = 43/234 (18%)
Query: 43 EILASLQKPKKISLKGSD-----GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAES 97
+++AS +KP + K +D + ++ K DDLR+D +++ I + + E+
Sbjct: 802 KVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQ----ILRIMESIWET 857
Query: 98 RRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSA 157
+L + Y I D+ G+IE V + T +++Q + +
Sbjct: 858 ESLDLCLLPYGCISTGDKIGMIEIVKDAT-----------------TIAKIQQSTVGNTG 900
Query: 158 ALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 217
A ++ + + W P + ++ + S A + ++LG+GD
Sbjct: 901 AFKDE--------------VLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGD 946
Query: 218 RHGENILFDSLTGECVHVDFNCLFNKGETF--EVPEIVPFRLTHNMVNGMGPMG 269
RH +NI+ TG H+DF + ++F E VPF LT + + MG G
Sbjct: 947 RHNDNIMITE-TGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSG 999
>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
sapiens]
Length = 1070
Score = 49.3 bits (116), Expect = 6e-06
Identities = 57/225 (25%), Positives = 92/225 (40%), Gaps = 42/225 (18%)
Query: 69 KPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL 128
K DDLR+D ++ L++ L K+A +L + Y + D G+IE V+ + +
Sbjct: 805 KNGDDLRQDMLTLQMLRLMD-LLWKEAGL---DLRMLPYGCLATGDRSGLIEVVSTSETI 860
Query: 129 RPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPD 188
I K+ L + + + + EF L
Sbjct: 861 ADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTL----------------- 903
Query: 189 PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF-NCLFNKGETF 247
S + YC + Y+LG+GDRH +NI+ TG+ H+DF + L N F
Sbjct: 904 ------SCAGYC-------VASYVLGIGDRHSDNIMVKK-TGQLFHIDFGHILGNFKSKF 949
Query: 248 EVP-EIVPFRLTHNMVN--GMGPMGTE---GLFRRACEVTMRLMR 286
+ E VPF LT++ ++ G G G FR+ CE ++R
Sbjct: 950 GIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILR 994
>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
[Homo sapiens]
Length = 1686
Score = 48.5 bits (114), Expect = 1e-05
Identities = 61/264 (23%), Positives = 104/264 (39%), Gaps = 45/264 (17%)
Query: 51 PKKISLKGSD--GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYA 108
P K+++ +D G+ +M K +DLR+D ++ +++K K+ +L + +
Sbjct: 1118 PLKVTMVNADPMGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEG----LDLRMVIFK 1173
Query: 109 VIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFRE 168
+ + G++E V + LR K+ E GV + K+ K A
Sbjct: 1174 CLSTGRDRGMVELVPASDTLR----KIQVEYGVTGSFKD-------KPLA---------- 1212
Query: 169 FLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSL 228
EW + P + + + S A + Y+LG+ DRH +NI+ S
Sbjct: 1213 -----------EWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRS- 1260
Query: 229 TGECVHVDFNCLFNKGETFE--VPEIVPFRLTHNMV----NGMGPMGTEGLFRRACEVTM 282
TG H+DF + F + PF LT +M G P LF C
Sbjct: 1261 TGHMFHIDFGKFLGHAQMFGSFKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAY 1320
Query: 283 RLMRDQREPLMSVLKTFLHDPLVE 306
L+R Q +++L + L E
Sbjct: 1321 NLIRKQTNLFLNLLSLMIPSGLPE 1344
>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
sapiens]
Length = 1044
Score = 48.1 bits (113), Expect = 1e-05
Identities = 58/236 (24%), Positives = 102/236 (43%), Gaps = 43/236 (18%)
Query: 58 GSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECG 117
GS G I+ K DDLR+D ++ L++ +++ +L + Y +P D G
Sbjct: 769 GSGGSVGIIF-KNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTG 823
Query: 118 IIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPI 177
+IE V + + I +L + + +AA ++ + +L ++P
Sbjct: 824 LIEVVLRSDTIANI---------------QLNKSNMAATAAFNKDALL--NWLKSKNPGE 866
Query: 178 FHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF 237
+ + F S + YC +T Y+LG+GDRH +NI+ +G+ H+DF
Sbjct: 867 ALDRAIEEFT------LSCAGYCVAT-------YVLGIGDRHSDNIMIRE-SGQLFHIDF 912
Query: 238 NCLFNKGET-FEV-PEIVPFRLTHNMVNGMGPMGTEG-----LFRRACEVTMRLMR 286
+T F + E VPF LT++ V+ + T FR CE ++R
Sbjct: 913 GHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
sapiens]
Length = 828
Score = 48.1 bits (113), Expect = 1e-05
Identities = 67/283 (23%), Positives = 120/283 (42%), Gaps = 55/283 (19%)
Query: 66 MMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNT 125
++ K DDLR++ L+ F L K L+ E R L I+ Y ++ ++ + G+IE V N
Sbjct: 573 VIVKCGDDLRQE--LLAFQVL--KQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNA 628
Query: 126 AGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRT 185
+ + K + LS ++ L H E FL
Sbjct: 629 VSIHQV----------------------KKQSQLS-----LLDYFLQEHGSYTTEAFL-- 659
Query: 186 FPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGE 245
S++ + +S A +V Y+L + DRH NIL D+ G +H+DF + +
Sbjct: 660 --------SAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDA-EGHIIHIDFGFILSSSP 710
Query: 246 TFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLH-DPL 304
E F+LT V+ MG G +G ++ M L ++ H D +
Sbjct: 711 RNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYKMLM---------LQGLIAARKHMDKV 759
Query: 305 VEWSKPVKGHSKAP-LNETGEVVNEKAKTHVLDIEQRLQGVIK 346
V+ + ++ S+ P + + + N K + H+ E++LQ +++
Sbjct: 760 VQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVE 802
>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1
[Homo sapiens]
Length = 854
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 179 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 236
+++F R + D ++ + +R + RS A S++ ++L + DRH NI+ D G +H+D
Sbjct: 669 YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 727
Query: 237 FNCLFNKGETFEVPEIVPFRLTHNMVNGMG 266
F +F + +LT MV MG
Sbjct: 728 FGFMFESSPGGNLGWEPDIKLTDEMVMIMG 757
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 43.9 bits (102), Expect = 2e-04
Identities = 26/90 (28%), Positives = 46/90 (51%), Gaps = 3/90 (3%)
Query: 179 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 236
+++F R + D ++ + +R + RS A S++ ++L + DRH NI+ D G +H+D
Sbjct: 1859 YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 1917
Query: 237 FNCLFNKGETFEVPEIVPFRLTHNMVNGMG 266
F +F + +LT MV MG
Sbjct: 1918 FGFMFESSPGGNLGWEPDIKLTDEMVMIMG 1947
>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
[Homo sapiens]
Length = 1445
Score = 43.1 bits (100), Expect = 4e-04
Identities = 61/284 (21%), Positives = 113/284 (39%), Gaps = 48/284 (16%)
Query: 35 IAGFD-DMVEILASLQKPKKISLKGSD--GKFYIMMCKPKDDLRKDCRLMEFNSLINKCL 91
I G D D S P KI+ ++ GK ++ K DDLR+D +++ +++
Sbjct: 884 IKGIDHDACSYFTSNALPLKITFINANPMGKNISIIFKAGDDLRQDMLVLQLIQVMDNIW 943
Query: 92 RKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQC 151
++ ++ + Y + + G+++ V + L K+++ G+ KE
Sbjct: 944 LQEG----LDMQMIIYRCLSTGKDQGLVQMVPDAV----TLAKIHRHSGLIGPLKENT-- 993
Query: 152 MLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGY 211
+ + F H +E LR F + S + +C +V +
Sbjct: 994 -------------IKKWFSQHNHLKADYEKALRNF------FYSCAGWC-------VVTF 1027
Query: 212 ILGLGDRHGENILFDSLTGECVHVDFNCLFNKGETFE--VPEIVPFRLTHNM-----VNG 264
ILG+ DRH +NI+ + +G H+DF +TF + PF T M G
Sbjct: 1028 ILGVCDRHNDNIML-TKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGG 1086
Query: 265 MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWS 308
P + C ++R + L+++L+ L+ L E S
Sbjct: 1087 KNPQHFQDFVELCCR-AYNIIRKHSQLLLNLLEMMLYAGLPELS 1129
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/196 (24%), Positives = 82/196 (41%), Gaps = 38/196 (19%)
Query: 69 KPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL 128
K DDLR+D ++ I + + +++ +L + Y + + D G+IE V N+ +
Sbjct: 802 KNGDDLRQDMLTLQ----IIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTI 857
Query: 129 RPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPD 188
I QC AL ++L ++ ++ + F
Sbjct: 858 MQI------------------QCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFT- 898
Query: 189 PTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF-NCLFNKGETF 247
S + YC +T +ILG+GDRH NI+ G+ H+DF + L +K + F
Sbjct: 899 -----RSCAGYCVAT-------FILGIGDRHNSNIMVKD-DGQLFHIDFGHFLDHKKKKF 945
Query: 248 EVP-EIVPFRLTHNMV 262
E VPF LT + +
Sbjct: 946 GYKRERVPFVLTQDFL 961
>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
type 3 alpha [Homo sapiens]
Length = 286
Score = 40.8 bits (94), Expect = 0.002
Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 3/65 (4%)
Query: 179 HEWFLRTFPDPTS--WYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVD 236
+++F R + D ++ + +R + RS A S++ ++L + DRH NI+ D G +H+D
Sbjct: 123 YDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDK-KGHIIHID 181
Query: 237 FNCLF 241
F +F
Sbjct: 182 FGFMF 186
>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
[Homo sapiens]
Length = 1634
Score = 38.1 bits (87), Expect = 0.014
Identities = 50/221 (22%), Positives = 87/221 (39%), Gaps = 44/221 (19%)
Query: 51 PKKISLKGSD--GKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYA 108
P K+S + D G+ ++ K DDLR+D ++ +++K ++ R + +
Sbjct: 1063 PLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVI----FR 1118
Query: 109 VIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFRE 168
G++E + N LR K+ E GV TG F++
Sbjct: 1119 CFSTGRGRGMVEMIPNAETLR----KIQVEHGV--TGS-------------------FKD 1153
Query: 169 FLLPRHPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSL 228
L +W + P + + + S A + Y+LG+ DRH +NI+ +
Sbjct: 1154 RPLA-------DWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKT- 1205
Query: 229 TGECVHVDFNCLFNKGETFE--VPEIVPFRLTHNM---VNG 264
TG H+DF + F + PF T +M +NG
Sbjct: 1206 TGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVING 1246
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 31.2 bits (69), Expect = 1.7
Identities = 23/89 (25%), Positives = 43/89 (48%), Gaps = 4/89 (4%)
Query: 80 LMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGL--RPILTKLYK 137
++E+NSL C+ E ++ + + + + IEWV+ GL + + + K
Sbjct: 479 ILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEEYKKESIEWVSIGFGLDLQACIDLIEK 538
Query: 138 EKGVYMTGKELRQCMLPKSAALSEKLKVF 166
G+ +E +CM PK+ L+ K K+F
Sbjct: 539 PMGILSILEE--ECMFPKATDLTFKTKLF 565
>gi|157364939 phosphodiesterase 6C [Homo sapiens]
Length = 858
Score = 30.0 bits (66), Expect = 3.7
Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 9/68 (13%)
Query: 316 KAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLL 375
K P++ETG V+ +++ ++ + GV NR G P + H Y+ + T
Sbjct: 374 KGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKP--FDEHDEYITETLT----- 426
Query: 376 CQMYLGWT 383
+LGW+
Sbjct: 427 --QFLGWS 432
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 28.9 bits (63), Expect = 8.2
Identities = 16/50 (32%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 81 MEFNSLINKCLRKDAESRRRELHIRTYAVIPLND--ECGIIEWVNNTAGL 128
+EF +NKCL K+ R + +A I +D E W+ +T GL
Sbjct: 332 LEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL 381
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 28.9 bits (63), Expect = 8.2
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 315 SKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQ 367
S+AP G VNE + +L +E Q + KT + S+EG+ +++
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 28.9 bits (63), Expect = 8.2
Identities = 15/53 (28%), Positives = 26/53 (49%)
Query: 315 SKAPLNETGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQ 367
S+AP G VNE + +L +E Q + KT + S+EG+ +++
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495
>gi|31563526 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 3 [Homo sapiens]
Length = 644
Score = 28.9 bits (63), Expect = 8.2
Identities = 15/50 (30%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 169 FLLPR-HPPIFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGD 217
F +P + P + +WF+ TF T W ++ S +++++GY LG+ D
Sbjct: 462 FTVPNCNKPRWEKWFMVTFASSTLWIAAFS--YMMVWMVTIIGYTLGIPD 509
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,433,565
Number of Sequences: 37866
Number of extensions: 681528
Number of successful extensions: 1327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1270
Number of HSP's gapped (non-prelim): 45
length of query: 386
length of database: 18,247,518
effective HSP length: 104
effective length of query: 282
effective length of database: 14,309,454
effective search space: 4035266028
effective search space used: 4035266028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.