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Search of human proteins with 110618250
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110618250 mucin and cadherin-like isoform 3 [Homo sapiens]
(651 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110618250 mucin and cadherin-like isoform 3 [Homo sapiens] 1319 0.0
gi|110618248 mucin and cadherin-like isoform 1 [Homo sapiens] 923 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 84 4e-16
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 80 4e-15
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 80 6e-15
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 80 6e-15
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 80 6e-15
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 80 6e-15
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 80 6e-15
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 80 6e-15
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 80 6e-15
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 80 6e-15
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 80 6e-15
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 80 6e-15
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 75 1e-13
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 70 5e-12
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 67 4e-11
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 67 5e-11
gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precurs... 65 3e-10
gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precurs... 65 3e-10
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 64 4e-10
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 64 4e-10
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 64 4e-10
gi|7661662 protocadherin beta 5 precursor [Homo sapiens] 64 4e-10
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 64 6e-10
gi|11056065 protocadherin gamma subfamily A, 6 isoform 1 precurs... 64 6e-10
gi|14196474 protocadherin gamma subfamily A, 6 isoform 2 precurs... 64 6e-10
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 62 1e-09
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 62 1e-09
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 62 1e-09
>gi|110618250 mucin and cadherin-like isoform 3 [Homo sapiens]
Length = 651
Score = 1319 bits (3414), Expect = 0.0
Identities = 651/651 (100%), Positives = 651/651 (100%)
Query: 1 MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEV 60
MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEV
Sbjct: 1 MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEV 60
Query: 61 TLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDN 120
TLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDN
Sbjct: 61 TLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDN 120
Query: 121 APEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSV 180
APEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSV
Sbjct: 121 APEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSV 180
Query: 181 NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC 240
NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC
Sbjct: 181 NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC 240
Query: 241 TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF 300
TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF
Sbjct: 241 TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF 300
Query: 301 IIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR 360
IIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR
Sbjct: 301 IIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR 360
Query: 361 GTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTT 420
GTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTT
Sbjct: 361 GTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTT 420
Query: 421 TLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVDMAALGGV 480
TLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVDMAALGGV
Sbjct: 421 TLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVDMAALGGV 480
Query: 481 LGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTH 540
LGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTH
Sbjct: 481 LGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTH 540
Query: 541 DPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFG 600
DPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFG
Sbjct: 541 DPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFG 600
Query: 601 EDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI 651
EDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI
Sbjct: 601 EDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI 651
>gi|110618248 mucin and cadherin-like isoform 1 [Homo sapiens]
Length = 845
Score = 923 bits (2385), Expect = 0.0
Identities = 490/613 (79%), Positives = 505/613 (82%), Gaps = 34/613 (5%)
Query: 1 MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEV 60
MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEV
Sbjct: 1 MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEV 60
Query: 61 TLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDN 120
TLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDN
Sbjct: 61 TLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDN 120
Query: 121 APEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSV 180
APEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSV
Sbjct: 121 APEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSV 180
Query: 181 NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC 240
NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC
Sbjct: 181 NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC 240
Query: 241 TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF 300
TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF
Sbjct: 241 TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF 300
Query: 301 IIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR 360
IIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR
Sbjct: 301 IIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR 360
Query: 361 GTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTT 420
GTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTT
Sbjct: 361 GTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTT 420
Query: 421 TLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVDMAALGGV 480
TLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPST PS + GG
Sbjct: 421 TLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTDVPPSPE----------AGGT 470
Query: 481 LGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQPQGFDNQAFLPDHKANWAPVP---- 536
G + GP G P G P + P
Sbjct: 471 TGP-WTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSG---TTLRPPTSSTPGGPPGAEN 526
Query: 537 SPTHDP-----KPAEAPMP--AEPAPPG--------PASP-GGAPEPPAAARAGGSPTAV 580
S +H P A+ P P ++P PPG PA+P GG + P + P ++
Sbjct: 527 STSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATPSGGTAQTPEPGTSQPMPPSM 586
Query: 581 RSILTKERRPEGG 593
+ + + GG
Sbjct: 587 GTSTSHQPATPGG 599
Score = 408 bits (1048), Expect = e-114
Identities = 194/195 (99%), Positives = 195/195 (100%)
Query: 457 PSTGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQP 516
PS+GGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQP
Sbjct: 651 PSSGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCSGKAPEPQP 710
Query: 517 QGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGS 576
QGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGS
Sbjct: 711 QGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGS 770
Query: 577 PTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGR 636
PTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGR
Sbjct: 771 PTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGR 830
Query: 637 GGGPYDAPGGDDSYI 651
GGGPYDAPGGDDSYI
Sbjct: 831 GGGPYDAPGGDDSYI 845
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 84.0 bits (206), Expect = 4e-16
Identities = 83/326 (25%), Positives = 135/326 (41%), Gaps = 30/326 (9%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D E+KS + G T + +VF+ V+D ND+ P+F E+ + EDT + ++
Sbjct: 1418 DAEQKSNYNLTVEATDGTTTILT-QVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEIL 1476
Query: 145 PETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLL 204
Q+ A D+D+ + L YTLQ S + +L LD T ++
Sbjct: 1477 ---QISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVM 1533
Query: 205 VRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILP 264
VRD P A +V+NV + PWF + Y G V +
Sbjct: 1534 VRDQD----VPVKRNFARIVVNVSDTNDHAPWF-----------TASSYKGRVYESAAVG 1578
Query: 265 SPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFL 322
S ++ + A D D+G N ++YSI GN+ +F+I P G++ A+ + + +
Sbjct: 1579 SVVL----QVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYD 1634
Query: 323 LLVKGQQADLARYS-VTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQ 381
L+VK S +T V + A + P+F + Y ++ G V A SQ
Sbjct: 1635 LMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQ 1694
Query: 382 PLRIQAQDPEFSDLNSAITYRITNHS 407
+ E D N+ + I HS
Sbjct: 1695 SSVVY----EIKDGNTGDAFDINPHS 1716
Score = 77.0 bits (188), Expect = 5e-14
Identities = 105/419 (25%), Positives = 171/419 (40%), Gaps = 51/419 (12%)
Query: 51 DIHVPEGQEVT---LGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
D + E+T LG+ + F +L + D EE+++ + GG Q
Sbjct: 3049 DADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQ 3108
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDK--DDILFYTLQ 165
+ +++ DVNDNAPEF I V E+T+ + + T++QA D D + + Y+L
Sbjct: 3109 ASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLL---TRVQATDADAGLNRKILYSLI 3165
Query: 166 EMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVL 225
+ G L + ++L++PLD R + L + + TAT T+++
Sbjct: 3166 DSADGQFSINELSGI----IQLEKPLD---RELQAVYTLSLKAVDQGLPRRLTATGTVIV 3218
Query: 226 NVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQ 285
+V+ + PP F + + +GA + IL VL+ +YA D N
Sbjct: 3219 SVLDINDNPPVF------------EYREYGATVSEDILVGTEVLQ---VYAASRDIEANA 3263
Query: 286 PIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQADLARYS-VTQVTV 342
I YSI GN +G F I +G + + ++ S + L V+ S V V V
Sbjct: 3264 EITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNV 3323
Query: 343 EAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYR 402
+ P F Q Y V+ +DA + + A D + NS I Y
Sbjct: 3324 NVTDINDNTPVFSQDTY---------TTVISEDAVLEQSVITVMADDAD-GPSNSHIHYS 3373
Query: 403 I---TNHSHFRME---GEVVLTTTTLAQAGAFYA-EVEA-HNTVTSGTATTVIEIQVSE 453
I S F ++ GEV +T + + Y V+A N TT + I VS+
Sbjct: 3374 IIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSD 3432
Score = 60.8 bits (146), Expect = 4e-09
Identities = 70/279 (25%), Positives = 120/279 (43%), Gaps = 30/279 (10%)
Query: 112 VSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGA 171
V V+D NDN PEF ++ + V ED +V+S +I Q++A D+D T +T
Sbjct: 810 VVVVDANDNPPEFLQESYFVEVSEDKEVHSEII---QVEATDKDLGPNGHVTYSIVT--D 864
Query: 172 SDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPAD 231
+D FS+ SV + + RPLD + + + RD E EP +T + +++ +
Sbjct: 865 TDTFSIDSVT-GVVNIARPLDRELQHEHSLKIEARDQARE--EPQLFSTVVVKVSLEDVN 921
Query: 232 LRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSI 291
PP F+P + + + +P G ++ + A D D G + + YS+
Sbjct: 922 DNPPTFIPPNY-------RVKVREDLPEGTVIMW--------LEAHDPDLGQSGQVRYSL 966
Query: 292 FRGNVNGTFIIHPDSGNLTVARSVPSP------MTFLLLVKGQQADLARYSVTQVTVEAV 345
+ G F + SG + + + + +T KG+ L+ +V V V
Sbjct: 967 L-DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDV 1025
Query: 346 AAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLR 384
PP F + +GTV A G +V +A + R
Sbjct: 1026 NENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
Score = 59.3 bits (142), Expect = 1e-08
Identities = 83/362 (22%), Positives = 132/362 (36%), Gaps = 43/362 (11%)
Query: 104 LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ----LQAEDRDKDDI 159
L T V V + D NDNAP F + E +NS V+ + ++A D DKD
Sbjct: 1745 LSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSN 1804
Query: 160 LFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTA 219
+ YF++ S + A+ LD+ E F + V D + + A
Sbjct: 1805 ALLVYHIVEPSVHTYFAIDS-STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAA 1863
Query: 220 TATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDG 279
T+ +V+ + PP F + Y ++ +LP+ ++ + A D
Sbjct: 1864 NVTV--HVIDINDCPPVFA-----------KPLYEASL----LLPTYKGVKVITVNATDA 1906
Query: 280 DRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQ 339
D +IYSI GN+ F + +G LTV + + L V+ A +T
Sbjct: 1907 DSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFA--GLTS 1964
Query: 340 VTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAI 399
V + + S +F Q +Y V + + A P +N +
Sbjct: 1965 VKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP------------INEPL 2012
Query: 400 TYRITNHSH----FRMEGEVVLTTTTL--AQAGAFYAEVE-AHNTVTSGTATTVIEIQVS 452
Y I N R G + T T Q AF VE S A V+++ V
Sbjct: 2013 FYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVE 2072
Query: 453 EQ 454
+Q
Sbjct: 2073 DQ 2074
Score = 58.9 bits (141), Expect = 1e-08
Identities = 79/339 (23%), Positives = 131/339 (38%), Gaps = 39/339 (11%)
Query: 109 RVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMT 168
R+ V+V D ND+AP F + + RV E V S V+ T L +D+ K+ + Y+++
Sbjct: 1547 RIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALD-KDKGKNAEVLYSIESGN 1605
Query: 169 AGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVV 228
G S P L + +R N + L+ + P T+ + V
Sbjct: 1606 IGNSFMID------PVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIF-VT 1658
Query: 229 PADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPII 288
AD P F +S + V G + G + A ++
Sbjct: 1659 IADNASPKFTSKEYS-------VELSETVSIGSFV--------GMVTAHS-----QSSVV 1698
Query: 289 YSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSV-TQVTVEAVAA 347
Y I GN F I+P SG + +++ + + Q ++A S T V V
Sbjct: 1699 YEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTNTTVLVHLQDE 1758
Query: 348 AGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-- 405
+ P F Q Y G ++ A VV + PL I+A D + D N+ + Y I
Sbjct: 1759 NDNAPVFMQAEYTGLISESASINSVV--LTDRNVPLVIRAADAD-KDSNALLVYHIVEPS 1815
Query: 406 -HSHFRMEGEVVLTTTTLA----QAGAFYAEVEAHNTVT 439
H++F ++ T L+ + F+ V+ H+ T
Sbjct: 1816 VHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGT 1854
Score = 56.2 bits (134), Expect = 9e-08
Identities = 85/377 (22%), Positives = 155/377 (41%), Gaps = 42/377 (11%)
Query: 38 EVEENTNVTEPLVDIHV--PEGQEVTLGALS-TPFA-FRIQGNQLFLNVTPDYEEKSLLE 93
E+ E+ V P+V + PEG +V PF+ F I N +NV + ++
Sbjct: 2190 EIAESIQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPA 2249
Query: 94 AQLLCQSGGTLV-TQLRVFVSVL--DVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQ 150
+L ++ +L VFV ++ D+NDN P F ++ + + E + + ++V+ Q++
Sbjct: 2250 YKLSIRATDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVV---QVR 2306
Query: 151 AEDRDKDDI--LFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
A D D + + Y + + + D+F V + + L R LD+ + T + VR
Sbjct: 2307 ATDSDSEPNRGISYQMFGNHSKSHDHFH-VDSSTGLISLLRTLDYEQSRQHT--IFVRAV 2363
Query: 209 PGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLV 268
G P+ ++ + ++V + PP F + +A+ P GH +
Sbjct: 2364 DGG--MPTLSSDVIVTVDVTDLNDNPPLFEQQIY-------EARISEHAPHGHFVTC--- 2411
Query: 269 LRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQ 328
+ A D D + YSI GN + F+I +G +T++ + +
Sbjct: 2412 -----VKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLS 2466
Query: 329 QADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQ 388
+D S TQV V + P F Q Y +A A +V + ++
Sbjct: 2467 VSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV---------MEVKTT 2517
Query: 389 DPEFSDLNSAITYRITN 405
D + S + +TY I N
Sbjct: 2518 DGD-SGIYGHVTYHIVN 2533
Score = 51.6 bits (122), Expect = 2e-06
Identities = 90/402 (22%), Positives = 158/402 (39%), Gaps = 50/402 (12%)
Query: 38 EVEENTNVTEPLVDIHV------PEGQEVTLGALSTPFAFRIQGNQLFLNVTP------D 85
EV E+ V ++ + P G VT ++ F I +N+
Sbjct: 830 EVSEDKEVHSEIIQVEATDKDLGPNGH-VTYSIVTDTDTFSIDSVTGVVNIARPLDRELQ 888
Query: 86 YEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIP 145
+E +EA+ + L + + V VS+ DVNDN P F ++V ED TVI
Sbjct: 889 HEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLP-EGTVIM 947
Query: 146 ETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLV 205
+ D + + Y+L + G D L A+R+ + LDF ++ +
Sbjct: 948 WLEAHDPDLGQSGQVRYSLLDHGEGNFDVDKLSG----AVRIVQQLDFEKKQVYNLTVRA 1003
Query: 206 RDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPS 265
+D G+ V S T + + V +L PP F +F + + P G ++ +
Sbjct: 1004 KD-KGKPVSLSSTCYVEVEVVDVNENLHPPVF--SSFVE-----KGTVKEDAPVGSLVMT 1055
Query: 266 PLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT---FL 322
+ A D D + I YSI G+ G F I ++G + + + T +L
Sbjct: 1056 --------VSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWL 1107
Query: 323 LLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQP 382
+ Q + S ++ +E + P+ + +Y + + V V
Sbjct: 1108 TVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV--------- 1158
Query: 383 LRIQAQDPEFSDLNSAITYRITN---HSHFRMEGEVVLTTTT 421
++I+A DP+ S N + Y+IT+ F + + L TTT
Sbjct: 1159 VQIEAFDPD-SSSNDKLMYKITSGNPQGFFSIHPKTGLITTT 1199
Score = 50.1 bits (118), Expect = 7e-06
Identities = 53/211 (25%), Positives = 87/211 (41%), Gaps = 25/211 (11%)
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDK--DDILFYTLQ 165
+ +++ V DVNDNAP+ + E++ + +V+ Q++A D D +D L Y +
Sbjct: 1123 IEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV---QIEAFDPDSSSNDKLMYKIT 1179
Query: 166 EMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVL 225
+ +FS+ R LD ++ + V D N P + A +++
Sbjct: 1180 --SGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTD----NGSPPKSTIARVIV 1233
Query: 226 NVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIY---AEDGDRG 282
++ + P FL Q Y +P R P+Y A D D G
Sbjct: 1234 KILDENDNKPQFL-----------QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEG 1282
Query: 283 INQPIIYSIFRGNVNGTFIIHPDSGNLTVAR 313
N I YSI GN +G F I P +G ++ R
Sbjct: 1283 PNAEISYSIEDGNEHGKFFIEPKTGVVSSKR 1313
Score = 47.4 bits (111), Expect = 4e-05
Identities = 89/401 (22%), Positives = 161/401 (40%), Gaps = 82/401 (20%)
Query: 96 LLCQSGGTLVTQLRVFVSVLDVNDNAPEF--PFKTKEIRVEEDTKVNSTVIPETQLQAED 153
++ + GG V V + +N P F PF + EI E +V+S V+ Q + +
Sbjct: 2154 VVAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIA--ESIQVHSPVV-HVQANSPE 2210
Query: 154 RDKDDILFYTLQEMTAGASDYFS--LVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGE 211
K +FY++ + D FS ++ N + + PLDF P + L +R T +
Sbjct: 2211 GLK---VFYSITD-----GDPFSQFTINFNTGVINVIAPLDFEAHP--AYKLSIRAT--D 2258
Query: 212 NVEPSHTATATLVLNVVPADL--RPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVL 269
++ +H A + ++++ D+ PP F Q Y + ++ + +V
Sbjct: 2259 SLTGAH---AEVFVDIIVDDINDNPPVF-----------AQQSYAVTLSEASVIGTSVV- 2303
Query: 270 RPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDS--GNLTVARSVPSPMT-----FL 322
+ A D D N+ I Y +F + H DS G +++ R++ + F+
Sbjct: 2304 ---QVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFV 2360
Query: 323 LLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQP 382
V G L+ S VTV+ +PP F Q++Y ++ A G V
Sbjct: 2361 RAVDGGMPTLS--SDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFV--------- 2409
Query: 383 LRIQAQDPEFSDLNSAITYRI---TNHSHFRMEGEV-VLTTTTL--------------AQ 424
++A D + SD++ + Y I +H HF ++ ++T + L
Sbjct: 2410 TCVKAYDADSSDIDK-LQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVS 2468
Query: 425 AGAFYAEVEAHNTVTSGT------ATTVIEIQVSEQEPPST 459
G F + + H TV G E++++E P T
Sbjct: 2469 DGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHT 2509
Score = 47.4 bits (111), Expect = 4e-05
Identities = 64/324 (19%), Positives = 127/324 (39%), Gaps = 45/324 (13%)
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ ++ +L+ + G V V V + D NDNAP+F E+ + ++V+
Sbjct: 2561 EKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLA 2620
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
A++ DI + + A + + +N+ + + N F VR
Sbjct: 2621 SDADEGSNADITY----AIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV 2676
Query: 209 PGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLV 268
+N PS + + + ++P +++ P FS+ + VP G +
Sbjct: 2677 --DNGSPSKESVVLVYVKILPPEMQLP-----KFSEPFYTFTVSED--VPIGTEIDL--- 2724
Query: 269 LRPGPIYAEDGDRGINQPIIYSIFRGNV-----NGTFIIHPDSGNLTVARSVPSPMT--- 320
I AE + ++YS+ +GN + +F+I SG L + +S+ T
Sbjct: 2725 -----IRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWY 2774
Query: 321 -FLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAP 379
F +L + Q D + V+++ A + P F Y +V++
Sbjct: 2775 QFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYE---------AFIVENLPGG 2825
Query: 380 SQPLRIQAQDPEFSDLNSAITYRI 403
S+ ++I+A D + S N + Y +
Sbjct: 2826 SRVIQIRASDAD-SGTNGQVMYSL 2848
Score = 46.2 bits (108), Expect = 9e-05
Identities = 75/365 (20%), Positives = 134/365 (36%), Gaps = 41/365 (11%)
Query: 35 DIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEA 94
D+ E + V LV + PE F Q +L L + D+E +
Sbjct: 2723 DLIRAEHSGTVLYSLVKGNTPESNR------DESFVIDRQSGRLKLEKSLDHETTKWYQF 2776
Query: 95 QLLC---QSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQA 151
+L Q +V + V + V D NDN+P F E + E+ S VI A
Sbjct: 2777 SILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDA 2836
Query: 152 EDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGE 211
+ +++ Q + + F+ +++ + + LD +R N ++ D GE
Sbjct: 2837 DSGTNGQVMYSLDQSQSVEVIESFA-INMETGWITTLKELDHEKRDNYQIKVVASD-HGE 2894
Query: 212 NVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV----PTGHILPSPL 267
++ S +TA + + V + PP F Y G V P G ++
Sbjct: 2895 KIQLS--STAIVDVTVTDVNDSPPRF-----------TAEIYKGTVSEDDPQGGVI---A 2938
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPM----TFLL 323
+L +E+ IN+ + Y I G+ G F + V P +LL
Sbjct: 2939 ILSTTDADSEE----INRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLL 2994
Query: 324 LVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPL 383
+ + ++ +V V + A + P + LY T+ G ++ +A +
Sbjct: 2995 TITATDGTFSSKAIVEVKV--LDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADI 3052
Query: 384 RIQAQ 388
R A+
Sbjct: 3053 RSNAE 3057
Score = 38.5 bits (88), Expect = 0.020
Identities = 75/324 (23%), Positives = 128/324 (39%), Gaps = 51/324 (15%)
Query: 112 VSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGA 171
+++ ++NDN P F E + D V + T + A D D+ ++ Y ++
Sbjct: 557 ITLNNLNDNTPLFEKINCEGTIPRDLGVGEQI---TTVSAIDADELQLVQYQIE--AGNE 611
Query: 172 SDYFSLVSVNRPALRLDRPLDFYERPNMTFWLL-VRDTPGEN----------VEPSH--- 217
D+FSL + N L L R L ++F L + T GEN V SH
Sbjct: 612 LDFFSL-NPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLV 670
Query: 218 ------TATATLVLNVV--PADLRPPWFLPCTFSDGYVCIQA---QYHGAVPTGHILPSP 266
T A ++ + L + F D + + A Q+ +PTG +
Sbjct: 671 NLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSH-SVNAHIPQFRSTLPTGIQVKEN 729
Query: 267 LVLRPGPIY--AEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLL 324
+ I+ + D D G N ++Y++ GN + F+I ++G L + + T
Sbjct: 730 QPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYT 789
Query: 325 VKGQQADL-----ARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAP 379
+ DL A + + V V V A +PP F Q Y V+ +D
Sbjct: 790 LNITVYDLGIPQKAAWRLLHVVV--VDANDNPPEFLQESYFVEVS---------EDKEVH 838
Query: 380 SQPLRIQAQDPEFSDLNSAITYRI 403
S+ ++++A D + N +TY I
Sbjct: 839 SEIIQVEATDKDLGP-NGHVTYSI 861
Score = 38.1 bits (87), Expect = 0.026
Identities = 59/313 (18%), Positives = 120/313 (38%), Gaps = 40/313 (12%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEE----DTKVN 140
+ +++ +LE + T RV V +LD NDN P+F K +IR+ E D + N
Sbjct: 1206 EQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERN 1265
Query: 141 STVIPETQLQAEDRDK--DDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPN 198
+ P + A D+D+ + + Y++++ + + + R ++
Sbjct: 1266 ARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD---- 1321
Query: 199 MTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVP 258
++ +N P ++T L + + P P +F + + + P
Sbjct: 1322 -----ILSIKAVDNGRPQKSSTTRLHIEWISKP--KPSLEPISFEESFFTFTVM--ESDP 1372
Query: 259 TGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSP 318
H++ V PG P+ + I GN + F + +G + VA+ + +
Sbjct: 1373 VAHMIGVISVEPPG------------IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE 1420
Query: 319 MTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAA 378
+ + D +TQV ++ + P+F Y V+ +D A
Sbjct: 1421 QKSNYNLTVEATDGTTTILTQVFIKVIDTNDHRPQFSTSKYE---------VVIPEDTAP 1471
Query: 379 PSQPLRIQAQDPE 391
++ L+I A D +
Sbjct: 1472 ETEILQISAVDQD 1484
Score = 31.2 bits (69), Expect = 3.1
Identities = 53/247 (21%), Positives = 99/247 (40%), Gaps = 39/247 (15%)
Query: 22 GTMAQAQYCSVNKDIFEVEENTNV------TEPLVDIHVPEGQEVTL------GALSTPF 69
GT + + +VN ++ ++ +NT V T + + V E +T+ G ++
Sbjct: 3311 GTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHI 3370
Query: 70 AFRI----QGNQLFLN-VTPDYEEKSLLEAQLLCQSGGTLVTQLR------------VFV 112
+ I QG+ ++ V + + LL+ + + SG TL Q V +
Sbjct: 3371 HYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETI--SGYTLTVQASDNGSPPRVNTTTVNI 3428
Query: 113 SVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGAS 172
V DVNDNAP F + ++E+ V +V+ + F+T+ +T
Sbjct: 3429 DVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTI--VTGNDE 3486
Query: 173 DYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADL 232
F VN + L +R +LL + +N +P ++ + + V+ +
Sbjct: 3487 KAF---EVNPQGVLLTS--SAIKRKEKDHYLL-QVKVADNGKPQLSSLTYIDIRVIEESI 3540
Query: 233 RPPWFLP 239
PP LP
Sbjct: 3541 YPPAILP 3547
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo
sapiens]
Length = 1790
Score = 80.5 bits (197), Expect = 4e-15
Identities = 91/349 (26%), Positives = 148/349 (42%), Gaps = 37/349 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 99 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 157
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 158 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 215
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 216 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 274
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 275 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 332
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 333 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 392
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDL 395
P F Y+G + A G + D+ + PLRI A D + D+
Sbjct: 393 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDV 441
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 775 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 834
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 835 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 888
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 889 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 938
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 939 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 989
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 990 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1041
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1042 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1096
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1097 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1154
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1155 VFQKKFYIGGVSEDAR 1170
Score = 39.7 bits (91), Expect = 0.009
Identities = 63/327 (19%), Positives = 128/327 (39%), Gaps = 38/327 (11%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE+ + G + V + V+D NDN P FP + ++ V D + +VI
Sbjct: 482 DREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVI 541
Query: 145 PETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLL 204
T + A++ +I + E+ GA F +++ + + ++ T+ L
Sbjct: 542 QLTAVDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALT 594
Query: 205 VRDTPGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHIL 263
V+ + T+ + V+P + + PP F +S + A+ G +L
Sbjct: 595 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVL 647
Query: 264 PSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--F 321
+ + A D + I Y+I G+ F + +G LT+ +++ T +
Sbjct: 648 LN--------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRY 696
Query: 322 LLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQ 381
+L++ S V + + P F L R + V + A +
Sbjct: 697 ILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAF 747
Query: 382 PLRIQAQDPEFSDLNSAITYRITNHSH 408
+++A DP+ + +N + Y + N ++
Sbjct: 748 VGQVKATDPD-AGINGQVHYSLGNFNN 773
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo
sapiens]
Length = 1955
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 94 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 152
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 153 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 210
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 211 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 270 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 327
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 435
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 823 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 876
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 926
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 927 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 978 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1084
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1085 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1143 VFQKKFYIGGVSEDAR 1158
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 414 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 534 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 586
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 637
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 638 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 688
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 689 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 739
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 740 KATDPD-AGINGQVHYSLGNFNN 761
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1731 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1785
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo
sapiens]
Length = 1932
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 72 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 130
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 131 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 188
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 189 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 247
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 248 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 305
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 306 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 365
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 366 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 413
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 741 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 800
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 801 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 854
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 855 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 904
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 905 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 955
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 956 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1007
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1008 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1062
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1063 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1120
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1121 VFQKKFYIGGVSEDAR 1136
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 392 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 451
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 452 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 512 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 564
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 565 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 615
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 616 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 666
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 667 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 717
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 718 KATDPD-AGINGQVHYSLGNFNN 739
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1708 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1762
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo
sapiens]
Length = 1677
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 94 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 152
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 153 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 210
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 211 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 270 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 327
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 435
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 823 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 876
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 926
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 927 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 978 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1084
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1085 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1143 VFQKKFYIGGVSEDAR 1158
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 414 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 534 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 586
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 637
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 638 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 688
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 689 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 739
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 740 KATDPD-AGINGQVHYSLGNFNN 761
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo
sapiens]
Length = 1682
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 99 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 157
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 158 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 215
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 216 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 274
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 275 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 332
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 333 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 392
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 393 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 440
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 768 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 827
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 828 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 881
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 882 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 931
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 932 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 982
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 983 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1034
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1035 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1089
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1090 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1147
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1148 VFQKKFYIGGVSEDAR 1163
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 419 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 478
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 479 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 538
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 539 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 591
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 592 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 642
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 643 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 693
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 694 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 744
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 745 KATDPD-AGINGQVHYSLGNFNN 766
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo
sapiens]
Length = 1539
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 94 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 152
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 153 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 210
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 211 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 270 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 327
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 435
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 823 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 876
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 926
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 927 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 978 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1084
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1085 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1143 VFQKKFYIGGVSEDAR 1158
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 414 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 534 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 586
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 637
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 638 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 688
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 689 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 739
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 740 KATDPD-AGINGQVHYSLGNFNN 761
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo
sapiens]
Length = 1935
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 72 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 130
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 131 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 188
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 189 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 247
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 248 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 305
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 306 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 365
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 366 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 413
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 741 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 800
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 801 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 854
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 855 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 904
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 905 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 955
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 956 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1007
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1008 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1062
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1063 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1120
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1121 VFQKKFYIGGVSEDAR 1136
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 392 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 451
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 452 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 511
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 512 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 564
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 565 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 615
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 616 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 666
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 667 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 717
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 718 KATDPD-AGINGQVHYSLGNFNN 739
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1711 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1765
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo
sapiens]
Length = 1952
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 94 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 152
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 153 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 210
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 211 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 270 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 327
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 435
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 823 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 876
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 926
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 927 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 978 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1084
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1085 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1143 VFQKKFYIGGVSEDAR 1158
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 414 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 534 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 586
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 637
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 638 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 688
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 689 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 739
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 740 KATDPD-AGINGQVHYSLGNFNN 761
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1728 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1782
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo
sapiens]
Length = 1886
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 94 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 152
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 153 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 210
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 211 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 270 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 327
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 435
Score = 58.5 bits (140), Expect = 2e-08
Identities = 87/305 (28%), Positives = 136/305 (44%), Gaps = 57/305 (18%)
Query: 110 VFVSVLDVNDNAPEF-PFKTKEIRVEEDTKVNSTVIPETQLQAEDRDK--DDILFYTLQE 166
V + V DVNDNAP F P+ + + V E+ + N+ V Q++A D D + + Y+L
Sbjct: 632 VNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFV---GQVKATDPDAGINGQVHYSL-- 685
Query: 167 MTAGASDYFSLVSVNR--PALRLDRPL-DFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
++ F + S A++L+R + D+YE L+V T G V P H +T TL
Sbjct: 686 --GNFNNLFRITSNGSIYTAVKLNREVRDYYE-------LVVVATDGA-VHPRH-STLTL 734
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGI 283
+ V+ D P F T++ V ++ +P G + I A+D D G
Sbjct: 735 AIKVLDIDDNSPVFTNSTYT---VLVEEN----LPAGTTILQ--------IEAKDVDLGA 779
Query: 284 NQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--------PSPMTFLLLVKGQQADLARY 335
N + Y I V F +HP +G L++ RS+ + +TFL+ +
Sbjct: 780 N--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP- 836
Query: 336 SVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAG-----VVVKDAAAPSQP---LRIQA 387
+ VTV PP F +R+Y+G VA A G V +DA P P +R +
Sbjct: 837 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 896
Query: 388 QDPEF 392
D +F
Sbjct: 897 DDVQF 901
Score = 53.1 bits (126), Expect = 8e-07
Identities = 100/463 (21%), Positives = 176/463 (38%), Gaps = 67/463 (14%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 414 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 534 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQ-- 584
Query: 209 PGENVEPSHTATATLVL-NVVPADLRPPWFLPCTFSDG----------YVCIQAQYHGAV 257
+N P+ +T L L + + + L T SDG + + A
Sbjct: 585 AADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 644
Query: 258 PTGHILPSPLVLRP-------GPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLT 310
LP L + G + A D D GIN + YS+ GN N F I + T
Sbjct: 645 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYT 702
Query: 311 VARSVPSPMTF--LLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAG 368
+ + L++V A R+S + ++ + + P F Y V
Sbjct: 703 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 762
Query: 369 AGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNH--SHF----RMEGEVVLTTTTL 422
AG + L+I+A+D DL + ++YRI + HF GE+ L +
Sbjct: 763 AGTTI---------LQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 810
Query: 423 AQAG-------AFYAEV-EAHNTVTSGTATTVIEIQVSEQEPP 457
+A F E + + T+ G AT + ++ PP
Sbjct: 811 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPP 853
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 692 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 751
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 752 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 805
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 806 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 855
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 856 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 906
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 907 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 958
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 959 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1013
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1014 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1071
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1072 VFQKKFYIGGVSEDAR 1087
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1662 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1716
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo
sapiens]
Length = 1957
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 94 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 152
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 153 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 210
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 211 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 269
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 270 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 327
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 328 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 387
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 388 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 435
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 823 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 876
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 877 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 926
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 927 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 977
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 978 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1030 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1084
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1085 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1143 VFQKKFYIGGVSEDAR 1158
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 414 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 474 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 534 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 586
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 587 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 637
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 638 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 688
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 689 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 739
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 740 KATDPD-AGINGQVHYSLGNFNN 761
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1733 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1787
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo
sapiens]
Length = 1962
Score = 80.1 bits (196), Expect = 6e-15
Identities = 91/348 (26%), Positives = 147/348 (42%), Gaps = 37/348 (10%)
Query: 78 LFLNVT--------PDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTK 129
LFLN T P +++ Q + + GT++ V + V D NDN+P F ++
Sbjct: 99 LFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH-EVRIVVRDRNDNSPTFKHESY 157
Query: 130 EIRVEEDTKVNSTVIPETQLQAEDRDKDD--------ILFYTLQEMTAGASDYFSLVSVN 181
V E T V +T+ D DD ++ Y + T+ +D F + +
Sbjct: 158 YATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS--NDTFEIPLML 215
Query: 182 RPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCT 241
+ L + L+ YE F ++ + +N+ T T TL ++V+ D P FLPC
Sbjct: 216 TGNIVLRKRLN-YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCV 274
Query: 242 F-SDGYVCIQAQYHGAVP---TGHILPSPLVLRPGPIYAEDGDRGINQP-----IIYSIF 292
+ C Y A+P T L +P+++ P PI A D DR I P I+YSI
Sbjct: 275 LVPNTRDCRPLTYQAAIPELRTPEEL-NPIIVTP-PIQAIDQDRNIQPPSDRPGILYSIL 332
Query: 293 RGNVNG---TFIIHPDSGNLTVARSVPSP--MTFLLLVKGQQAD-LARYSVTQVTVEAVA 346
G F +HP + L++ V F L++K +Q + + + +E +
Sbjct: 333 VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 392
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
P F Y+G + A G + D+ + PLRI A D + D
Sbjct: 393 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED 440
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 768 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 827
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 828 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 881
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 882 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 931
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 932 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 982
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 983 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1034
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 1035 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1089
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1090 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1147
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1148 VFQKKFYIGGVSEDAR 1163
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 419 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 478
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 479 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 538
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 539 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 591
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 592 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 642
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 643 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 693
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 694 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 744
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 745 KATDPD-AGINGQVHYSLGNFNN 766
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1738 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1792
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 75.5 bits (184), Expect = 1e-13
Identities = 98/381 (25%), Positives = 150/381 (39%), Gaps = 56/381 (14%)
Query: 47 EPLVDIHVPEGQEVT--LGALS-----TPFAFRIQGNQ-------------LFLNVTPDY 86
EP + V E VT +G +S TP F I G + + D
Sbjct: 1364 EPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDA 1423
Query: 87 EEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPE 146
E++S+ + + GT V +VF+ VLD NDN PEF ++ + ED V+P+
Sbjct: 1424 EQRSIYNMSVEV-TDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTISED------VLPD 1476
Query: 147 T---QLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWL 203
T Q++A DRD+ L YT+ S + + L LD + +
Sbjct: 1477 TEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNI 1536
Query: 204 LVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHIL 263
+VRD P A +++NV A+ P+F Y +V L
Sbjct: 1537 MVRD----QEFPYRRNLARVIVNVEDANDHSPYF-----------TNPLYEASVFESAAL 1581
Query: 264 PSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--- 320
S ++ + A D D+G N +IY+I GN F I P G +T+ + P T
Sbjct: 1582 GSAVL----QVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE-PDMTTMGQ 1636
Query: 321 FLLLVKGQQADLARYSVTQ-VTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAP 379
F+L +K S T V + + S P+F + Y+ V G V +A
Sbjct: 1637 FVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI 1696
Query: 380 SQPLRIQAQDPEFSDLNSAIT 400
SQ I + + D+N T
Sbjct: 1697 SQSTLI--YEVKDGDINGIFT 1715
Score = 68.9 bits (167), Expect = 1e-11
Identities = 91/370 (24%), Positives = 154/370 (41%), Gaps = 40/370 (10%)
Query: 9 PPLLFTGLLVRPPGTMAQAQYCS-VNKDI-FEVEENTNVTEPLVDIHVPEGQ----EVTL 62
PP+ T + VR TM+ + ++KD EV EN ++ ++ I EV
Sbjct: 1649 PPMSATAI-VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQSTLIYEVKD 1707
Query: 63 GALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAP 122
G ++ F + DYE S + + + + + V + ++D NDNAP
Sbjct: 1708 GDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASNATVNIQIVDENDNAP 1767
Query: 123 EFPFKTKEIRVEEDTKVNSTV----IPETQLQAEDRD--KDDILFYTLQEMTAGASDYFS 176
F F + E +NS V ++A D D ++ +L Y + E TA F
Sbjct: 1768 VFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTA---KKFF 1824
Query: 177 LVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADL--RP 234
V + A+R LD + F + VRD+ P TA + + +N+ D+ P
Sbjct: 1825 TVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG----SPQLTAESPVEVNIEVTDVNDNP 1880
Query: 235 PWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRG 294
P F F T +LP+ + + + A D D + + YS+ G
Sbjct: 1881 PVFTQAVFE---------------TILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEG 1925
Query: 295 NVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRF 354
+++ F+I +SG LT+ + S ++L+VK +D YS + VT+ A S F
Sbjct: 1926 SLD-HFLIDSNSGVLTIKNNNLSKDHYMLIVK--VSDGKFYSTSMVTIMVKEAMDSGLHF 1982
Query: 355 PQRLYRGTVA 364
Q Y +++
Sbjct: 1983 TQSFYSTSIS 1992
Score = 62.0 bits (149), Expect = 2e-09
Identities = 91/377 (24%), Positives = 155/377 (41%), Gaps = 47/377 (12%)
Query: 59 EVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSL------LEAQLLCQSGGTLVTQLRVFV 112
EVT L+ F I + + V + +S +EA+ +SG L + + + V
Sbjct: 865 EVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKV 924
Query: 113 SVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGAS 172
+ DVND +P F + ++V ED V TVI + D + Y+L +
Sbjct: 925 FLDDVNDCSPAFIPSSYSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSL------VN 977
Query: 173 DYFSLVSVNRP--ALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPA 230
DY +++ A+RL + LD+ ++ + +D G V S + + + V
Sbjct: 978 DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD-KGRPVSLSSVSFVEVEVVDVNE 1036
Query: 231 DLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYS 290
+L P+ F D V + + + T + + A D D G + I YS
Sbjct: 1037 NLHTPY-----FPDFAVVGSVKENSRIGTSVL----------QVTARDEDSGRDGEIQYS 1081
Query: 291 IFRGNVNGTFIIHPDSGNLTVARSVPSPMT---FLLLVKGQQADLARYSVTQVTVEAVAA 347
I G+ G F I +SG +T A + +L + + + YS +V +E
Sbjct: 1082 IRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDV 1141
Query: 348 AGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-- 405
+ P + +Y V + V V ++IQA+DP+ S N +TYRIT+
Sbjct: 1142 NDNAPLTSEPIYYPVVMENSPKDVSV---------IQIQAEDPD-SSSNEKLTYRITSGN 1191
Query: 406 -HSHFRMEGEVVLTTTT 421
+ F + + L TTT
Sbjct: 1192 PQNFFAINIKTGLITTT 1208
Score = 62.0 bits (149), Expect = 2e-09
Identities = 78/311 (25%), Positives = 135/311 (43%), Gaps = 42/311 (13%)
Query: 101 GGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRD--KDD 158
GG Q + + + DVNDN P F V E+T + + T++QA D D +
Sbjct: 3108 GGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALL---TRVQAVDPDIGINR 3164
Query: 159 ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRD-TPGENVEPSH 217
+ Y+L + G FS+ S + + L++PLD ++ + + D +PG+++
Sbjct: 3165 KVVYSLADSAGGV---FSIDS-SSGIIILEQPLDREQQSSYNISVRATDQSPGQSL---- 3216
Query: 218 TATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAE 277
++ T+ + V+ + PP F + Y VP P VL ++A
Sbjct: 3217 SSLTTVTITVLDINDNPPVF-----------ERRDYLVTVPE-DTSPGTQVL---AVFAT 3261
Query: 278 DGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPM--TFLLLVKGQQADL-AR 334
D G N I Y I GN G F I+P +G ++V+ + + F L+V+ + A
Sbjct: 3262 SKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPAL 3321
Query: 335 YSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSD 394
+V V + +PP+F Q +Y + V+ +DA + + A+D + S
Sbjct: 3322 SAVATVNINLTDVNDNPPKFSQDVY---------SAVISEDALVGDSVILLIAEDVD-SQ 3371
Query: 395 LNSAITYRITN 405
N I + I N
Sbjct: 3372 PNGQIHFSIVN 3382
Score = 60.1 bits (144), Expect = 6e-09
Identities = 85/342 (24%), Positives = 138/342 (40%), Gaps = 28/342 (8%)
Query: 39 VEENTNVTEPLVDIHV--PEGQEVTLGALS-TPFA-FRIQGNQLFLNVTP--DYEEKSLL 92
V E+ + P++ I+ PEGQ + + PF F I + L V DYE S
Sbjct: 2195 VNEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAY 2254
Query: 93 EAQLLCQSGGTLV-TQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQA 151
+ + T ++ V + V DVNDN P F T + E + + + V+ + A
Sbjct: 2255 KLTIRASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDA 2314
Query: 152 EDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGE 211
D + + ++ Y + + T ++DYF + S + L R LD + T L VR +
Sbjct: 2315 -DSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTA-RMLDHELVQHCT--LKVRSI--D 2368
Query: 212 NVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRP 271
+ PS ++ + + + + PP F + + YV A P GH +
Sbjct: 2369 SGFPSLSSEVLVHIYISDVNDNPPVFNQLIY-ESYVSELA------PRGHFVTC------ 2415
Query: 272 GPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQAD 331
+ A D D + YSI GN +F++ SG +T++ M L + +D
Sbjct: 2416 --VQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSD 2473
Query: 332 LARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
S QV + + A P F Q Y V AG V
Sbjct: 2474 GLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKV 2515
Score = 52.4 bits (124), Expect = 1e-06
Identities = 102/417 (24%), Positives = 155/417 (37%), Gaps = 58/417 (13%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE+ + + + G VTQ V VSV DVNDN+P + ED N ++
Sbjct: 2991 DREEQDIYFLNITA-TDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIIL 3049
Query: 145 PETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLL 204
++ A+D D + +G S++F + L+ LD P + L+
Sbjct: 3050 ---KVSAKDADIGSNGYIRYSLYGSGNSEFF--LDPESGELKTLALLDRERIP--VYSLM 3102
Query: 205 VRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGY-VCIQAQYHGAVPTGHIL 263
+ T G + + L + + PP F SD Y C+ +
Sbjct: 3103 AKATDGGG----RFCQSNIHLILEDVNDNPPVFS----SDHYNTCVYE---------NTA 3145
Query: 264 PSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----RSVPSPM 319
L+ R + A D D GIN+ ++YS+ + G F I SG + + R S
Sbjct: 3146 TKALLTR---VQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSY 3201
Query: 320 TFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAP 379
+ Q + S+T VT+ + +PP F +R Y TV G V A
Sbjct: 3202 NISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFAT 3261
Query: 380 SQPLRIQAQDPEFSDLNSAITYRI---TNHSHFRME----GEVVLTTTTLAQAGAFYAEV 432
S+ + N+ ITY I F++ G V FY V
Sbjct: 3262 SKDI----------GTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVV 3311
Query: 433 EAHNTVT---SGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVDMAALGGVLGALLL 486
EA + T S AT I + PP S+D +V+ AL G LL+
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKF----SQDVYSAVISEDALVGDSVILLI 3364
Score = 47.0 bits (110), Expect = 6e-05
Identities = 65/280 (23%), Positives = 110/280 (39%), Gaps = 34/280 (12%)
Query: 101 GGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDIL 160
G +L + V ++VLD+NDN P F + + V EDT P TQ+ A DI
Sbjct: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTS------PGTQVLAVFATSKDI- 3265
Query: 161 FYTLQEMT----AGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPS 216
T E+T +G ++ + + LD+ F+L+V G P+
Sbjct: 3266 -GTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDY--ELCKRFYLVVEAKDGGT--PA 3320
Query: 217 HTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYA 276
+A AT+ +N+ + PP F Q Y + ++ ++L + A
Sbjct: 3321 LSAVATVNINLTDVNDNPPKF-----------SQDVYSAVISEDALVGDSVIL----LIA 3365
Query: 277 EDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLVKGQQADL-A 333
ED D N I +SI G+ + F + P G + V + + + LLV+ + + A
Sbjct: 3366 EDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPA 3425
Query: 334 RYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
S V ++ + P F Y + G +
Sbjct: 3426 MSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSI 3465
Score = 44.3 bits (103), Expect = 4e-04
Identities = 66/304 (21%), Positives = 113/304 (37%), Gaps = 81/304 (26%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRV-EEDTKVNSTVIPETQLQAEDRDK------------ 156
V V VLD NDN P+FP K +I++ E D K P + A DRD+
Sbjct: 1240 VVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGE--PIYRAFAFDRDEGPNAEISYSIVD 1297
Query: 157 --DDILFY---------TLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLV 205
DD F+ + ++ TAG+ D ++ +V
Sbjct: 1298 GNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIKAV------------------------- 1332
Query: 206 RDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPS 265
+N P ++TA L + + PP +P TF + + Y+ V
Sbjct: 1333 -----DNGRPQKSSTARLHIEWIKKP--PPSPIPLTFDEPF------YNFTVMESD---- 1375
Query: 266 PLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLV 325
R I + N P+ + I GN + F G + +A+ + + + +
Sbjct: 1376 ----RVTEIVGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNM 1431
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
+ D +VTQV ++ + + P F Q Y T++ +D ++ L+I
Sbjct: 1432 SVEVTDGTNVAVTQVFIKVLDNNDNGPEFSQPNYDVTIS---------EDVLPDTEILQI 1482
Query: 386 QAQD 389
+A D
Sbjct: 1483 EATD 1486
Score = 43.1 bits (100), Expect = 8e-04
Identities = 74/370 (20%), Positives = 145/370 (39%), Gaps = 50/370 (13%)
Query: 106 TQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQ 165
+++ V + + +VNDN+P F + + D V + T + A D D+ +++ Y
Sbjct: 560 SEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHI---TAVSAIDIDELELVKY--- 613
Query: 166 EMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVL 225
++ +G F ++ + L+L + L N F L + T GEN+ + +++
Sbjct: 614 KIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLH 673
Query: 226 NVVPAD------------------LRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
V + ++ DG++ + PS +
Sbjct: 674 GKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDV 733
Query: 268 VLRPG--------PIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPM 319
++ I A D D G N ++++I GN + F I ++G L V +
Sbjct: 734 AVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREH 793
Query: 320 TFLLLVKGQQADLA---RYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDA 376
T L L+ DL + S +T+ A + P F Q Y + +G G +
Sbjct: 794 TDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEI--- 850
Query: 377 AAPSQPLRIQAQDPEFSDLNSAITYRI-TNHSHFRME---GEVVLTTTTLAQAGAFYA-E 431
++++A+D + N +TY + T+ F + G V + ++ A Y+ +
Sbjct: 851 ------IQVEARDKDLGS-NGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLK 903
Query: 432 VEAHNTVTSG 441
+EA + SG
Sbjct: 904 IEARDKAESG 913
Score = 43.1 bits (100), Expect = 8e-04
Identities = 64/293 (21%), Positives = 117/293 (39%), Gaps = 48/293 (16%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVF---VSVLDVNDN--APEFPFKTKEIRVEEDTKV 139
DYE++ + + G V+ V V V+DVN+N P FP V+E++++
Sbjct: 999 DYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRI 1058
Query: 140 NSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNM 199
++V+ T + ED +D + Y++++ FS+ + + D +R M
Sbjct: 1059 GTSVLQVTA-RDEDSGRDGEIQYSIRD--GSGLGRFSIDDESG----VITAADILDRETM 1111
Query: 200 -TFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVP 258
++WL V T V P ++ Y+ ++ A
Sbjct: 1112 GSYWLTVYATD-RGVVPLYSTIEV-----------------------YIEVEDVNDNAPL 1147
Query: 259 TGHILPSPLVLRPGP-------IYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
T + P+V+ P I AED D N+ + Y I GN F I+ +G +T
Sbjct: 1148 TSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITT 1207
Query: 312 -ARSVPSPMT---FLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYR 360
+R + FL + + S V V+ + + P+FP+++Y+
Sbjct: 1208 TSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ 1260
Score = 43.1 bits (100), Expect = 8e-04
Identities = 58/226 (25%), Positives = 92/226 (40%), Gaps = 26/226 (11%)
Query: 104 LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYT 163
L + + V++ V DVNDNAP V E++ + +VI Q+QAED D T
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI---QIQAEDPDSSSNEKLT 1184
Query: 164 LQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
+ + ++F++ R LD ++ + V D G + + S T +
Sbjct: 1185 YRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDG-GPSPKQS---TIWV 1240
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIY---AEDGD 280
V+ V+ + P F + Y +P R PIY A D D
Sbjct: 1241 VVQVLDENDNKPQFP-----------EKVYQIKLPE-----RDRKKRGEPIYRAFAFDRD 1284
Query: 281 RGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVK 326
G N I YSI GN +G F I P +G ++ + + +L +K
Sbjct: 1285 EGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTIK 1330
Score = 40.8 bits (94), Expect = 0.004
Identities = 68/304 (22%), Positives = 120/304 (39%), Gaps = 44/304 (14%)
Query: 112 VSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGA 171
++V D NDN+P F + + + E + + + +I Q++A D+D T +T
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII---QVEARDKDLGSNGEVTYSVLT--D 873
Query: 172 SDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPAD 231
+ F++ S D+ LD + N + + RD E + + L V D
Sbjct: 874 TQQFAINSSTGIVYVADQ-LDRESKANYSLKIEARD----KAESGQQLFSVVTLKVFLDD 928
Query: 232 LR--PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIY 289
+ P F+P ++S + +P G ++ + D D G+ + Y
Sbjct: 929 VNDCSPAFIPSSYS-------VKVLEDLPVGTVI--------AWLETHDPDLGLGGQVRY 973
Query: 290 SIFRGNVNGTFIIHPDSGNLTVARSVPSP------MTFLLLVKGQQADLARYSVTQVTVE 343
S+ + NG F I SG + +++ + +T KG+ L+ S +V V
Sbjct: 974 SLV-NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVV 1032
Query: 344 AVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRI 403
V P FP G+V + G V L++ A+D E S + I Y I
Sbjct: 1033 DVNENLHTPYFPDFAVVGSVKENSRIGTSV---------LQVTARD-EDSGRDGEIQYSI 1082
Query: 404 TNHS 407
+ S
Sbjct: 1083 RDGS 1086
Score = 39.3 bits (90), Expect = 0.011
Identities = 74/304 (24%), Positives = 116/304 (38%), Gaps = 40/304 (13%)
Query: 103 TLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFY 162
+L +++ V + + DVNDN P F E V E V T +QA D D D F
Sbjct: 2373 SLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV---TCVQASDADSSD--FD 2427
Query: 163 TLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATAT 222
L+ +D S + ++ + + +R + L V + G T+TA
Sbjct: 2428 RLEYSILSGNDRTSFLMDSKSGV-ITLSNHRKQRMEPLYSLNVSVSDG-----LFTSTAQ 2481
Query: 223 LVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRG 282
+ + V+ A+L P F T+ A+ V G + + A DGD G
Sbjct: 2482 VHIRVLGANLYSPAFSQSTYV-------AEVRENVAAG--------TKVIHVRATDGDPG 2526
Query: 283 INQPIIYSIFRGNVNGTFIIHPDSGNLT---VARSVPSPMTFLLLVKGQQADLARYSVTQ 339
I Y+I F+I + +T + R P + V+ R +
Sbjct: 2527 TYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENPLEGDVSIFVRALDGG-GRTTFCT 2585
Query: 340 VTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAI 399
V V V + P+F YR +V G G +V ++QA DP+ NS I
Sbjct: 2586 VRVIVVDENDNAPQFMTVEYRASVRADVGRGHLV---------TQVQAIDPD-DGANSRI 2635
Query: 400 TYRI 403
TY +
Sbjct: 2636 TYSL 2639
Score = 36.2 bits (82), Expect = 0.097
Identities = 44/207 (21%), Positives = 81/207 (39%), Gaps = 24/207 (11%)
Query: 109 RVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMT 168
+V +S+ D ND+ PEF + V E V ++V+ + A D+DK + + T +
Sbjct: 457 QVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVL---TVSASDKDKGENGYITYSIAS 513
Query: 169 AGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVV 228
+ +++ + LDF P + +++ G H + + + +
Sbjct: 514 LNLLPF--VINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYR--HESEVNVTIRIG 569
Query: 229 PADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPII 288
+ P F + C + GHI + A D D + +
Sbjct: 570 NVNDNSPLF------EKVACQGVISYDFPVGGHIT---------AVSAIDIDE--LELVK 612
Query: 289 YSIFRGNVNGTFIIHPDSGNLTVARSV 315
Y I GN G F ++PDSG L + +S+
Sbjct: 613 YKIISGNELGFFYLNPDSGVLQLKKSL 639
Score = 36.2 bits (82), Expect = 0.097
Identities = 84/400 (21%), Positives = 153/400 (38%), Gaps = 57/400 (14%)
Query: 40 EENTNVTEPLVDIHVPE--GQEVTLGALSTPFAFRIQGNQLFLNVTP---DYEEKSLLEA 94
E NTN+T+ + V + + L+ F+I+ + T D EE+ L E
Sbjct: 1993 ENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYE- 2051
Query: 95 QLLCQSGGTL----VTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQ 150
L+ ++ L V ++ V V++ D+NDN+P F V+ D + + + T +
Sbjct: 2052 -LVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAID 2110
Query: 151 AEDRDKDDILFYTLQEMTAGASDYFSL-VSVNRPALRLDRPLDFYERPNMTF--WLLVRD 207
+D+ + + Y LQ+ DY ++ N + L + + N+ + +L +D
Sbjct: 2111 -KDKGPNGEVTYVLQD------DYGHFEINPNSGNVILKEAFN-SDLSNIEYGVTILAKD 2162
Query: 208 TPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
++ S T+V +P P++ D
Sbjct: 2163 GGKPSLSTSVELPITIVNKAMPV-FDKPFYTASVNED----------------------- 2198
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKG 327
+ PI + + Q IIY I G+ F I D+G L V + +T +
Sbjct: 2199 IRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTI 2258
Query: 328 QQADLARYSVTQVTVEAVA--AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
+ +D + +VTV+ + +PP F Q Y T++ + G V Q + I
Sbjct: 2259 RASDALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPV------LQVVSI 2312
Query: 386 QAQDPEFSDLNSAI---TYRITNHSHFRMEGEVVLTTTTL 422
A ++ I TY T++ H ++LT L
Sbjct: 2313 DADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARML 2352
Score = 34.7 bits (78), Expect = 0.28
Identities = 64/288 (22%), Positives = 101/288 (35%), Gaps = 38/288 (13%)
Query: 36 IFEVEENTNVTEPLVDIHVPEGQEVTLGALS----TPFA---FRIQGNQLFLNVTPDYEE 88
+ EV EN ++ + +G T G +S FA F I N + T +
Sbjct: 2502 VAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVIT-TERLDR 2560
Query: 89 KSLLEAQLL----CQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
++ LE + GG T V V V+D NDNAP+F V D V
Sbjct: 2561 ENPLEGDVSIFVRALDGGGRTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVT 2620
Query: 145 PETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLL 204
+ +D I + E + +D L+ ++ + +F + N
Sbjct: 2621 QVQAIDPDDGANSRITYSLYSEASVSVAD---LLEIDPDNGWMVTKGNFNQLKNTVLSFF 2677
Query: 205 VRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGY---VCIQAQYHGAVPTGH 261
V+ G P + + ++V+P P FLP Y + V T
Sbjct: 2678 VKAVDGG--IPVKHSLIPVYIHVLP----PETFLPSFTQSQYSFTIAEDTAIGSTVDTLR 2731
Query: 262 ILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNL 309
ILPS V +G+R N N G F+I ++G +
Sbjct: 2732 ILPSQNVW----FSTVNGERPEN----------NKGGIFVIEQETGTI 2765
Score = 33.9 bits (76), Expect = 0.48
Identities = 74/368 (20%), Positives = 140/368 (38%), Gaps = 53/368 (14%)
Query: 96 LLCQSGGTLVTQLRVFVSVLDVNDNAPEF--PFKTKEIRVEEDTKVNSTVIPETQLQAED 153
+L + GG V + + VN P F PF T V ED ++N+ ++ + A
Sbjct: 2158 ILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTAS--VNEDIRMNTPIL---SINATS 2212
Query: 154 RDKDDILFYTLQEMTAGASDYFSLVSV--NRPALRLDRPLDFYERPNMTFWLLVRDTPGE 211
+ I++ + D F ++ + L++ PLD+ + L +R
Sbjct: 2213 PEGQGIIYIIID------GDPFKQFNIDFDTGVLKVVSPLDY--EVTSAYKLTIR---AS 2261
Query: 212 NVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRP 271
+ A T+ L V + PP F Q Y+ + ++ +P++
Sbjct: 2262 DALTGARAEVTVDLLVNDVNDNPPIF-----------DQPTYNTTLSEASLIGTPVL--- 2307
Query: 272 GPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPD--SGNLTVARSVPSPMTFLLLVKGQQ 329
+ + D D N+ + Y I + N T H D SG + AR + + +K +
Sbjct: 2308 -QVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRS 2366
Query: 330 ADLARYSVTQ---VTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQ 386
D S++ V + +PP F Q +Y V+ A G V +Q
Sbjct: 2367 IDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFV---------TCVQ 2417
Query: 387 AQDPEFSDLNSAITYRI---TNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTA 443
A D + SD + + Y I + + F M+ + + T + + + +V+ G
Sbjct: 2418 ASDADSSDFD-RLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLF 2476
Query: 444 TTVIEIQV 451
T+ ++ +
Sbjct: 2477 TSTAQVHI 2484
Score = 32.3 bits (72), Expect = 1.4
Identities = 64/302 (21%), Positives = 112/302 (37%), Gaps = 44/302 (14%)
Query: 101 GGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDIL 160
G L +V + VLD+ND P F T + + E T + ++V T A+ +
Sbjct: 135 GEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFY 194
Query: 161 FYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTAT 220
+Y ++ D FS V + L L++ E+ +L D G + ++ +
Sbjct: 195 YYFKNKV-----DLFS-VHPTSGVISLSGRLNYDEKNRYDLEILAVDR-GMKLYGNNGVS 247
Query: 221 ATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPS-PLVLRPGPIYA--- 276
+T L YV I+ + + PT H++ P L P YA
Sbjct: 248 STAKL--------------------YVHIE-RINEHAPTIHVVTHVPFSLEKEPTYAVVT 286
Query: 277 -EDGDRGINQPI-IYSIFRGNVNGTFIIHPDSGNLTVAR----------SVPSPMTFLLL 324
+D D G N I SI G+ F + + L + S P L
Sbjct: 287 VDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
Query: 325 VKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLR 384
K + + ++ V + P RF + +Y +++ + GVVV +P+
Sbjct: 347 AKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID 406
Query: 385 IQ 386
++
Sbjct: 407 VE 408
Score = 30.8 bits (68), Expect = 4.1
Identities = 47/214 (21%), Positives = 79/214 (36%), Gaps = 47/214 (21%)
Query: 104 LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYT 163
+V + V + VLD+NDN P F + + + E V + + TQ++A D D
Sbjct: 2794 IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKL---TQVRAIDMD-------- 2842
Query: 164 LQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
A +SL S ++P ++ ++ + + T W+ + H T
Sbjct: 2843 ---WGANGQVTYSLHSDSQP----EKVMEAFNIDSNTGWISTLK------DLDHETDPTF 2889
Query: 224 VLNVVPADLRPPWFLPCTF----------SDGYVCIQAQYHGAVPTGHILPSPLVLRPGP 273
+VV +DL + L T + V Q Y G V PG
Sbjct: 2890 TFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESD--------PPGE 2941
Query: 274 IYA-----EDGDRGINQPIIYSIFRGNVNGTFII 302
+ A + +N+ + Y I GN G F +
Sbjct: 2942 VVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFAL 2975
Score = 30.0 bits (66), Expect = 7.0
Identities = 33/119 (27%), Positives = 46/119 (38%), Gaps = 16/119 (13%)
Query: 289 YSIFRGNVNGTFIIHPDSGNLTVARSVPSPM--TFLLLVKGQQADLARYSVTQVTVEAVA 346
Y + G F I+P SG + AR + + + L V ++ DL QVT+
Sbjct: 409 YKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK----AQVTISIED 464
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITN 405
A P F Q LY V G V L + A D + + N ITY I +
Sbjct: 465 ANDHTPEFQQPLYDAYVNESVPVGTSV---------LTVSASDKDKGE-NGYITYSIAS 513
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo
sapiens]
Length = 1915
Score = 70.5 bits (171), Expect = 5e-12
Identities = 80/317 (25%), Positives = 133/317 (41%), Gaps = 35/317 (11%)
Query: 105 VTQLRVFVSVLDVNDNAPEFPFKTKEIRVE-EDTKVNSTVIPETQLQAEDRD------KD 157
V Q+ S V D P + ++V+ + KV + + E ++ DR+ K
Sbjct: 90 VKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 158 DILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTP-----GEN 212
+ + T+ E+T + F+ S + A +D + PN +++ P +N
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDID------DGPNGQIEYVIQYNPDDPDRAQN 203
Query: 213 VEPSHTATATLVLNVVPADLRPPWFLPCTF-SDGYVCIQAQYHGAVP---TGHILPSPLV 268
+ T T TL ++V+ D P FLPC + C Y A+P T L +P++
Sbjct: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL-NPII 262
Query: 269 LRPGPIYAEDGDRGINQP-----IIYSIFRGNVNGT---FIIHPDSGNLTVARSVPSPM- 319
+ P PI A D DR I P I+YSI G F +HP + L++ V
Sbjct: 263 VTP-PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFH 321
Query: 320 -TFLLLVKGQQADLARY-SVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAA 377
F L++K +Q + + + +E + P F Y+G + A G + D+
Sbjct: 322 QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 381
Query: 378 APSQPLRIQAQDPEFSD 394
+ PLRI A D + D
Sbjct: 382 NLTSPLRIVALDKDIED 398
Score = 67.4 bits (163), Expect = 4e-11
Identities = 107/423 (25%), Positives = 167/423 (39%), Gaps = 71/423 (16%)
Query: 82 VTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
V D+ +K L + +G L + + +LD N+ +P F + + + E V +
Sbjct: 316 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 375
Query: 142 TVIPETQLQ------AEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPA----LRLDRPL 191
T+ L A D+D +D E+ +DY S+ +V + L L +P+
Sbjct: 376 TISDSLNLTSPLRIVALDKDIEDT---KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPV 432
Query: 192 DFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQA 251
D E+ TF + D E+ EP + + V+ A+ P F ++ D YV
Sbjct: 433 DREEQQTYTFSITAFDGVQES-EP-----VIVNIQVMDANDNTPTFPEISY-DVYVYTD- 484
Query: 252 QYHGAVPTGHILPSPLVLRPG----PIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSG 307
+RPG + A D D G N I Y I G G FII+ +G
Sbjct: 485 -----------------MRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTG 526
Query: 308 NLTVARSVPSPMTFLLLVKGQQADLA-----RYSVTQVTVEAVAAAG-SPPRFPQRLYRG 361
+T+A V + + Q AD A R S+ V +E + SPPRFPQ +Y
Sbjct: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 362 TVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTT 421
++ G V+ L +QA D E +ITY I N R+ + TT
Sbjct: 587 EISEAMRVGAVL---------LNLQATDRE----GDSITYAIENGDPQRV-FNLSETTGI 632
Query: 422 LAQAGAFYAE--------VEAHNTVTSGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVD 473
L A E + A + GT+T + I V++ + P + SVV+
Sbjct: 633 LTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVE 692
Query: 474 MAA 476
A
Sbjct: 693 EEA 695
Score = 47.4 bits (111), Expect = 4e-05
Identities = 107/436 (24%), Positives = 163/436 (37%), Gaps = 78/436 (17%)
Query: 71 FRIQGN-QLFLNVTPDYEEKSLLEAQLLCQSGGTLV--TQLRVFVSVLDVNDNAPEFPFK 127
FRI N ++ V + E + E ++ G + L + + VLD++DN+P F
Sbjct: 726 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 785
Query: 128 TKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRL 187
T + VEE+ +T++ Q++A+D D + Y ++ +F + L L
Sbjct: 786 TYTVLVEENLPAGTTIL---QIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSL 839
Query: 188 DRPLDFYERP----NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFS 243
R LD+ P ++TF + D G P AT T++ V + PP F
Sbjct: 840 LRSLDYEAFPDQEASITFLVEAFDIYG--TMPPGIATVTVI--VKDMNDYPPVF------ 889
Query: 244 DGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD-------------RGINQPIIYS 290
+ Y G V + +P+ +YAED D + P S
Sbjct: 890 -----SKRIYKGMVAPDAVKGTPIT----TVYAEDADPPGLPASRVRYRVDDVQFPYPAS 940
Query: 291 IFRGNVNGTFIIHPDSGN-LTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE-AVAAA 348
IF + DSG +T P T LV D + TV+ V
Sbjct: 941 IFE--------VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 992
Query: 349 GSPPRFPQRLYR-----GTVARGAGAGVVVKDAAAPSQPL---RIQAQDPEFSDLNSAIT 400
G PRF Q YR +G GV+ AAA +Q + + + + +N+
Sbjct: 993 GEIPRFTQEEYRPPPVSELATKGTMVGVI--SAAAINQSIVYSIVSGNEEDTFGINN--- 1047
Query: 401 YRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHN---TVTSGTATTVIEIQVSEQEPP 457
IT + + T+ + + A EV N S TA IEIQ PP
Sbjct: 1048 --ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1105
Query: 458 STG-----GGPSEDKR 468
GG SED R
Sbjct: 1106 VFQKKFYIGGVSEDAR 1121
Score = 40.4 bits (93), Expect = 0.005
Identities = 73/383 (19%), Positives = 149/383 (38%), Gaps = 48/383 (12%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVT--------LGALSTPFAFRIQGNQLFLNVTP--DYEE 88
+ ++ N+T PL + + + E T L ++ F G +L + D EE
Sbjct: 377 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 436
Query: 89 KSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ 148
+ + G + V + V+D NDN P FP + ++ V D + +VI T
Sbjct: 437 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 496
Query: 149 LQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDT 208
+ A++ +I + E+ GA F +++ + + ++ T+ L V+
Sbjct: 497 VDADEGSNGEITY----EILVGAQGDF-IINKTTGLITIAPGVEMI--VGRTYALTVQAA 549
Query: 209 PGENVEPSHTATATLVLNVVPADLR-PPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ T+ + V+P + + PP F +S + A+ G +L +
Sbjct: 550 DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS-------LEISEAMRVGAVLLN-- 600
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT--FLLLV 325
+ A D + I Y+I G+ F + +G LT+ +++ T ++L++
Sbjct: 601 ------LQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILII 651
Query: 326 KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRI 385
S V + + P F L R + V + A + ++
Sbjct: 652 TASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPR---------NLSVVEEEANAFVGQV 702
Query: 386 QAQDPEFSDLNSAITYRITNHSH 408
+A DP+ + +N + Y + N ++
Sbjct: 703 KATDPD-AGINGQVHYSLGNFNN 724
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 519 FDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGG----APEPPA 569
F+N A P+ + P+P P P+ P PA APP SP P PP+
Sbjct: 1691 FENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPS 1745
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 67.4 bits (163), Expect = 4e-11
Identities = 74/288 (25%), Positives = 131/288 (45%), Gaps = 35/288 (12%)
Query: 103 TLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFY 162
T+ TQ+ +F+ + ++N + P+F E+RV +DT ++ ++QA D+DK L Y
Sbjct: 1428 TIATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELL---RVQAIDQDKGKSLIY 1483
Query: 163 TLQ-EMTAGASDYFSLVSVNRPALRLDRPLDFYERPNM-TFWLLVRDTPGENVEPSHTAT 220
T+ G++ F L + + + + LD P+ T ++VRD P
Sbjct: 1484 TIHGSQDPGSASLFQLDPSSGVLVTVGK-LDLGSGPSQHTLTVMVRDQE----IPIKRNF 1538
Query: 221 ATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD 280
+ ++V +L PP F Q Y +VP I P +L+ + A D D
Sbjct: 1539 VWVTIHVEDGNLHPPRFT-----------QLHYEASVPDT-IAPGTELLQ---VRAMDAD 1583
Query: 281 RGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP----SPMTFLLLVKGQ-QADLARY 335
RG+N + YS+ +GN G F I+ G +T+A+ + +P T L VK + Q +
Sbjct: 1584 RGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHT--LTVKAEDQGSPQWH 1641
Query: 336 SVTQVTVEAVAAAGSPPRFPQRLYRGTVARG--AGAGVVVKDAAAPSQ 381
+ V + + S P F + Y + G+ +++ A +PS+
Sbjct: 1642 DLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSE 1689
Score = 60.8 bits (146), Expect = 4e-09
Identities = 77/324 (23%), Positives = 135/324 (41%), Gaps = 42/324 (12%)
Query: 92 LEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQA 151
+EA+ G L + + +++ DVNDN+P+ + ++V ED + + T L A
Sbjct: 893 VEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVL---TFLDA 949
Query: 152 EDRDKDDI--LFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP--NMTFWLLVRD 207
D D + Y L + GA F V + AL L+R LDF R N++ W
Sbjct: 950 SDPDLGPAGEVRYVLMD---GAHGTFR-VDLMTGALILERELDFERRAGYNLSLWASDGG 1005
Query: 208 TPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
P H L +N +L PP F Q Q P+G + +
Sbjct: 1006 RPLARRTLCHVEVIVLDVN---ENLHPPHFASFVH-------QGQVQENSPSG----TQV 1051
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT---FLLL 324
++ + A+D D G++ + Y + G F I+ D+G + + +L +
Sbjct: 1052 IV----VAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTV 1107
Query: 325 VKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLR 384
+ + + SVT+V +E A +PP+ Q ++ ++ A G V L+
Sbjct: 1108 LAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV---------LQ 1158
Query: 385 IQAQDPEFSDLNSAITYRITNHSH 408
+ A DP+ S +T+ IT+ ++
Sbjct: 1159 LDAWDPD-SSSKGKLTFNITSGNY 1181
Score = 60.8 bits (146), Expect = 4e-09
Identities = 86/322 (26%), Positives = 126/322 (39%), Gaps = 38/322 (11%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D E K + GG Q + + V DVNDNAP F + V ++T V T +
Sbjct: 3074 DRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTV-KTPV 3132
Query: 145 PETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLL 204
+ D+ + + Y+L + G +FS + +RL++PL RP L
Sbjct: 3133 AVVFARDPDQGANAQVVYSLPDSAEG---HFS-IDATTGVIRLEKPLQV--RPQAPLELT 3186
Query: 205 VRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILP 264
VR + P T T+ ++VV + P FL S +Q A P +L
Sbjct: 3187 VRASDLGTPIPLST-LGTVTVSVVGLEDYLPVFLNTEHS-----VQVP-EDAPPGTEVLQ 3239
Query: 265 SPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV---PSPMTF 321
+ RPG + Y + GN G F + +G L V S+ SP F
Sbjct: 3240 LATLTRPGA-----------EKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYF 3288
Query: 322 LLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQ 381
L + +++ + VT V V P+FPQ Y V A G V+
Sbjct: 3289 LSIECSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVI-------- 3340
Query: 382 PLRIQAQDPEFSDLNSAITYRI 403
L + A D E LNS ITY +
Sbjct: 3341 -LTVSATD-EDGPLNSDITYSL 3360
Score = 60.1 bits (144), Expect = 6e-09
Identities = 81/366 (22%), Positives = 147/366 (40%), Gaps = 44/366 (12%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTA 169
V VSV+ + D P F ++V ED + V+ L +K T + +
Sbjct: 3204 VTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAEK------TGYRVVS 3257
Query: 170 GASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVP 229
G + L ++ LDF P ++L + + S + T+++N+
Sbjct: 3258 GNEQGRFRLDARTGILYVNASLDFETSPK--YFLSIECS--RKSSSSLSDVTTVMVNITD 3313
Query: 230 ADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIY 289
+ P F +S + + L ++L + A D D +N I Y
Sbjct: 3314 VNEHRPQFPQDPYSTRVL------------ENALVGDVILT---VSATDEDGPLNSDITY 3358
Query: 290 SIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLAR---YSVTQVTVEAVA 346
S+ GN G F IHP G L VA+++ +K + D + + T + ++
Sbjct: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
Query: 347 AAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRIT-- 404
+PPRF Q Y TV + G S+ L++ DP+ + ++RIT
Sbjct: 3419 VNDNPPRFFQLNYSTTVQENSPIG---------SKVLQLILSDPDSPENGPPYSFRITKG 3469
Query: 405 -NHSHFRM--EGEVVLTTTTLAQAGAFY-AEVEAHNT-VTSGTATTVIEIQVSEQEPPST 459
N S FR+ +G +V +A +Y +++A ++ + ++ T + + V+EQ +
Sbjct: 3470 NNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAP 3529
Query: 460 GGGPSE 465
P E
Sbjct: 3530 SALPLE 3535
Score = 53.9 bits (128), Expect = 5e-07
Identities = 71/318 (22%), Positives = 125/318 (39%), Gaps = 39/318 (12%)
Query: 38 EVEENTNVTEPLVDIHVPEGQEVTL----GALSTPFAFRIQGNQLFLNVTPDYEEKSLLE 93
E+ E+ V P++ + EVT G F+ + D+E+ S +
Sbjct: 1668 EIPESIPVGSPILLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQ 1727
Query: 94 AQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQ----L 149
++ + T + V V ++D NDNAP F T ++ E + S ++ + +
Sbjct: 1728 LKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVI 1787
Query: 150 QAEDRDKD--DILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRD 207
A D DK+ +L Y + E A F + + L + +D+ P+ F + V D
Sbjct: 1788 HASDSDKEANSLLVYKILEPEALK---FFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHD 1844
Query: 208 TPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPL 267
+ A ++++V + PP F Q + G I P
Sbjct: 1845 QGSPVLFAPR--PAQVIIHVRDVNDSPPRF------------SEQIYEVAIVGPIHPGME 1890
Query: 268 VLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKG 327
+L + A D D +N YSI GN + IHP +G+++V ++ L ++
Sbjct: 1891 LLM---VRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLTIRA 1943
Query: 328 -----QQADLARYSVTQV 340
Q L + S+TQV
Sbjct: 1944 SDGLYQDTALVKISLTQV 1961
Score = 48.5 bits (114), Expect = 2e-05
Identities = 85/386 (22%), Positives = 155/386 (40%), Gaps = 53/386 (13%)
Query: 39 VEENTNVTEPLVDIHVPEGQEVTLGALSTPFA-----FRIQG--NQLFLNVTPDYEEKSL 91
+++ T + L + + T GA++ FA FRI + L DY+ +
Sbjct: 2079 IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYTYFRIDPYLGDISLKKPFDYQALNK 2138
Query: 92 LEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQA 151
+++ + GGT Q V V N + P F ++RV E+ + + ++ QA
Sbjct: 2139 YHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLFQSPYYKVRVPENITLYTPIL---HTQA 2195
Query: 152 EDRDKDDILFYTLQE--MTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTP 209
+ +++ ++E + +D+ + V L + PLD+ + F + DT
Sbjct: 2196 RSPEGLRLIYNIVEEEPLMLFTTDFKTGV------LTVTGPLDYESKTKHVFTVRATDT- 2248
Query: 210 GENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVL 269
+ AT+ + V + PP TFS Q Y ++ G +P++
Sbjct: 2249 ----ALGSFSEATVEVLVEDVNDNPP-----TFS------QLVYTTSISEGLPAQTPVI- 2292
Query: 270 RPGPIYAEDGDRGINQPIIYSIFR--GNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKG 327
+ A D D G N+ + Y I +V+ F I+ +G ++ + + VK
Sbjct: 2293 ---QLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKV 2349
Query: 328 QQADLARYSVTQVTVEAVAAA---GSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLR 384
+ D +T T+ V + +PP F Q Y V+ A G +V L+
Sbjct: 2350 RAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLV---------LK 2400
Query: 385 IQAQDPEFSDLNSAITYRITNHSHFR 410
+QA DP+ D S + Y I + + R
Sbjct: 2401 VQAIDPDSRD-TSRLEYLILSGNQDR 2425
Score = 47.0 bits (110), Expect = 6e-05
Identities = 82/346 (23%), Positives = 131/346 (37%), Gaps = 45/346 (13%)
Query: 69 FAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLV---TQLRVFVSVLDVNDNA--PE 123
F + L L D+E ++ L GG + T V V VLDVN+N P
Sbjct: 972 FRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPH 1031
Query: 124 FPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSL---VSV 180
F + +V+E++ + VI Q +D D L Y L+ T A+ FS+ +
Sbjct: 1032 FASFVHQGQVQENSPSGTQVIV-VAAQDDDSGLDGELQYFLRAGTGLAA--FSINQDTGM 1088
Query: 181 NRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPC 240
+ LDR Y +WL V +V S + + + V A+ PP
Sbjct: 1089 IQTLAPLDREFASY------YWLTVLAVDRGSVPLS--SVTEVYIEVTDANDNPPQMSQA 1140
Query: 241 TFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTF 300
F Y IQ +P+ + A D D + ++I GN G F
Sbjct: 1141 VF---YPSIQED------------APVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
Query: 301 IIHPDSGNLTVARSVP---SPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQR 357
+IHP +G L+ A+ + L + + + S ++V V + +PP F +
Sbjct: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
Query: 358 LYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRI 403
L+ + +P R+ A D + LN +TY I
Sbjct: 1246 LFNVRLPERL-------SPVSPGPVYRLVASDLD-EGLNGRVTYSI 1283
Score = 46.6 bits (109), Expect = 7e-05
Identities = 66/275 (24%), Positives = 108/275 (39%), Gaps = 25/275 (9%)
Query: 106 TQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYT 163
++ V V V DVNDN P F + E + VI QL A D+D ++ + Y
Sbjct: 2254 SEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVI---QLLASDQDSGRNRDVSYQ 2310
Query: 164 LQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
+ E + S +F ++ + + + LD+ + + F + VR + +P T +
Sbjct: 2311 IVEDGSDVSKFFQ-INGSTGEMSTVQELDYEAQQH--FHVKVRAM--DKGDPPLTGETLV 2365
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGI 283
V+NV + PP F + +A GH LVL+ + A D D
Sbjct: 2366 VVNVSDINDNPPEFRQPQY-------EANVSELATCGH-----LVLK---VQAIDPDSRD 2410
Query: 284 NQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVE 343
+ Y I GN + F I+ SG +++ + ++ +D + V +
Sbjct: 2411 TSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYIN 2470
Query: 344 AVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAA 378
A P F Q LY +A A G V D A
Sbjct: 2471 TTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLA 2505
Score = 45.8 bits (107), Expect = 1e-04
Identities = 89/484 (18%), Positives = 178/484 (36%), Gaps = 75/484 (15%)
Query: 38 EVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLN----------VTPDYE 87
E+ EN V ++D+ + G + ++ + +N + +
Sbjct: 2489 ELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENS 2548
Query: 88 EKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPET 147
+ ++ +++ + GG V V + + D NDN P+F + ++ + +S VI
Sbjct: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
Query: 148 QLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRD 207
A++ D+ + E D + V +++ L E + F++ +D
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLV--KDVIEINPVTG-VVKVKDSLVGLENQTLDFFIKAQD 2665
Query: 208 TPGENVEPSHTATATLVLNVVPADLRPPWFLP--CTFSDGYVCIQAQYHGAVPTGHILPS 265
P + + L VVP + P F TFS + G V
Sbjct: 2666 ----GGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKA------ 2715
Query: 266 PLVLRPGPIYAEDGDRGINQPIIYSIFRG-----NVNGTFIIHPDSGNLTVARSVPSPMT 320
+ A+D P+IYS+ RG N +G F + PD+G + V + + T
Sbjct: 2716 --------VAAQD-------PVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHEST 2760
Query: 321 FLLLVKG-----QQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKD 375
L + Q D+ S+ V ++ + P F Y+ + G V
Sbjct: 2761 KLYQIDVMAHCLQNTDVV--SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV-- 2816
Query: 376 AAAPSQPLRIQAQDPEFSDLNSAITYRITN------HSHFRMEGEVVLTTT------TLA 423
+++ A D + + + ++YR++ H F ++ E TT
Sbjct: 2817 -------IQVTAIDKD-TGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETC 2868
Query: 424 QAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTGGGPSEDKRFSVVDMAALGGVLGA 483
Q F+ H ++ ++++ +++ E + SE+ R SVV+ + G ++
Sbjct: 2869 QTYHFHVVAYDHGQTIQLSSQALVQVSITD-ENDNAPRFASEEYRGSVVENSEPGELVAT 2927
Query: 484 LLLL 487
L L
Sbjct: 2928 LKTL 2931
Score = 43.9 bits (102), Expect = 5e-04
Identities = 69/273 (25%), Positives = 106/273 (38%), Gaps = 30/273 (10%)
Query: 112 VSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGA 171
V+V D NDNAP FP ++ + EDT+V +T+ T A+ D + YTL T
Sbjct: 808 VNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVR-YTLLSPT--- 863
Query: 172 SDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPAD 231
+ FSL + L + LD P + RD P + H + L + D
Sbjct: 864 -EKFSLHPLT-GELVVTGHLDRESEPRYILKVEARDQPSK----GHQLFSVTDLIITLED 917
Query: 232 LRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSI 291
+ + CI H + LP VL + A D D G + Y +
Sbjct: 918 VN---------DNSPQCITE--HNRLKVPEDLPPGTVLT--FLDASDPDLGPAGEVRYVL 964
Query: 292 FRGNVNGTFIIHPDSGNLTVARSVP----SPMTFLLLVKGQQADLARYSVTQVTVEAVAA 347
G +GTF + +G L + R + + L LAR ++ V V +
Sbjct: 965 MDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDV 1023
Query: 348 AGS--PPRFPQRLYRGTVARGAGAGVVVKDAAA 378
+ PP F +++G V + +G V AA
Sbjct: 1024 NENLHPPHFASFVHQGQVQENSPSGTQVIVVAA 1056
Score = 43.5 bits (101), Expect = 6e-04
Identities = 70/347 (20%), Positives = 130/347 (37%), Gaps = 50/347 (14%)
Query: 107 QLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQE 166
++ +F+ + ++NDN P F + +D V +++ + + D D++ +
Sbjct: 547 EVSIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSAI-----DVDELQNLKYEI 601
Query: 167 MTAGASDYFSL------VSVNRPALRLD--RPLDF-----------YERPNMTFWLLVRD 207
++ +YF L +S+ RP + L +P + Y P +V+D
Sbjct: 602 VSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKD 661
Query: 208 TPGE--------NVEPSHTATATLVLNVVPADLRPPWFLPC-TFSDGYVCIQAQYHGAVP 258
E V T T + + + F T+ + Q + H
Sbjct: 662 PHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQS 721
Query: 259 TGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSP 318
+ P+ + A D D G N ++Y I GN G F I ++G LTVA +
Sbjct: 722 IDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYE 781
Query: 319 MTFLLLVKGQQADLA---RYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKD 375
T ++ DL + S +TV + PRFP Y+ T++ G + +
Sbjct: 782 ATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGGYQLTISEDTEVGTTIAE 841
Query: 376 AAAPSQPLRIQAQDPEFSDLNSAITYRITN----HSHFRMEGEVVLT 418
+ +D + D N + Y + + S + GE+V+T
Sbjct: 842 ---------LTTKDADSED-NGRVRYTLLSPTEKFSLHPLTGELVVT 878
Score = 41.2 bits (95), Expect = 0.003
Identities = 55/257 (21%), Positives = 98/257 (38%), Gaps = 26/257 (10%)
Query: 57 GQEVTLGALSTPFAFRIQGNQLFLNVTPDYEE--KSLLEAQLLCQSGGTLVTQLRVFVSV 114
G V G F + L++N + D+E K L + +S +L V V++
Sbjct: 3252 GYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNI 3311
Query: 115 LDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDY 174
DVN++ P+FP RV E+ V ++ + + DI + + G +
Sbjct: 3312 TDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLG---H 3368
Query: 175 FSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRP 234
F+ + + L++ + LD + + + L D+ P H T + + V + P
Sbjct: 3369 FT-IHPKKGELQVAKALDREQASSYSLKLRATDS---GQPPLHEDT-DIAIQVADVNDNP 3423
Query: 235 PWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGIN-QPIIYSIFR 293
P F +S +Q SP+ + + D D N P + I +
Sbjct: 3424 PRFFQLNYS---TTVQEN------------SPIGSKVLQLILSDPDSPENGPPYSFRITK 3468
Query: 294 GNVNGTFIIHPDSGNLT 310
GN F + PD +T
Sbjct: 3469 GNNGSAFRVTPDGWLVT 3485
Score = 40.0 bits (92), Expect = 0.007
Identities = 66/303 (21%), Positives = 116/303 (38%), Gaps = 54/303 (17%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI-------PETQLQAEDRDKDDILFY 162
V + V + +AP F + + E V S ++ E + + +KD +
Sbjct: 1646 VIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREGNKDGVF-- 1703
Query: 163 TLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATAT 222
+ Y L+S + +LD +E+ + ++ L +R G N+ + T
Sbjct: 1704 -------SMNSYSGLISTQK---KLD-----HEKIS-SYQLKIR---GSNMAGAFT-DVM 1743
Query: 223 LVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRG 282
+V++++ + P FL TF G + A + + + P I+A D D+
Sbjct: 1744 VVVDIIDENDNAPMFLKSTFV-GQISEAAPLYSMIMDKNN-------NPFVIHASDSDKE 1795
Query: 283 INQPIIYSIFRGNVNGTFIIHPDSGNLTVA-----RSVPSPMTFLLLVKGQQAD-LARYS 336
N ++Y I F I P G LT+ S+PS F + V Q + L
Sbjct: 1796 ANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPS-FQFCVYVHDQGSPVLFAPR 1854
Query: 337 VTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLN 396
QV + SPPRF +++Y V + P L + E S++N
Sbjct: 1855 PAQVIIHVRDVNDSPPRFSEQIYE----------VAIVGPIHPGMELLMVRASDEDSEVN 1904
Query: 397 SAI 399
+I
Sbjct: 1905 YSI 1907
Score = 36.6 bits (83), Expect = 0.075
Identities = 63/287 (21%), Positives = 110/287 (38%), Gaps = 31/287 (10%)
Query: 100 SGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDI 159
S G + V + VLDVNDN+P+ +V ED ++ ++ A D D D
Sbjct: 2987 SDGKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFIL---KVSATDLDTDTN 3043
Query: 160 LFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTA 219
T GA ++ + + L LD ER ++ F L+ + T G +
Sbjct: 3044 AQITYSLHGPGAHEF--KLDPHTGELTTLTALD-RERKDV-FNLVAKATDG----GGRSC 3095
Query: 220 TATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDG 279
A + L+V + P F P C A + + +P+ + ++A D
Sbjct: 3096 QADITLHVEDVNDNAPRFFPSH------CAVAVFDNTT-----VKTPVAV----VFARDP 3140
Query: 280 DRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV----PSPMTFLLLVKGQQADLARY 335
D+G N ++YS+ + G F I +G + + + + +P+ + +
Sbjct: 3141 DQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
Query: 336 SVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQP 382
++ VTV V P F + V A G V A ++P
Sbjct: 3200 TLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRP 3246
Score = 30.8 bits (68), Expect = 4.1
Identities = 34/140 (24%), Positives = 58/140 (41%), Gaps = 20/140 (14%)
Query: 274 IYAEDGDRGINQPIIYSIFR---GNVNGTFIIHPDSGNLTVARSVPSP--MTFLLLV--- 325
+ A D D G + + Y + NV+ F I +SG +T + + T+ V
Sbjct: 2819 VTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY 2878
Query: 326 -KGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLR 384
GQ L+ ++ QV++ + PRF YRG+V + G +V
Sbjct: 2879 DHGQTIQLSSQALVQVSI--TDENDNAPRFASEEYRGSVVENSEPGELV---------AT 2927
Query: 385 IQAQDPEFSDLNSAITYRIT 404
++ D + S+ N +T IT
Sbjct: 2928 LKTLDADISEQNRQVTCYIT 2947
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 67.0 bits (162), Expect = 5e-11
Identities = 87/316 (27%), Positives = 131/316 (41%), Gaps = 35/316 (11%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
DYE K+ +L GT L + + V+VLDVND AP F E V+E+
Sbjct: 1228 DYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEF 1287
Query: 143 VIPETQLQAEDRDKDDILFYTLQ-EMTAGASDYFSLVSVNRPALRLDRP--LDFYERPNM 199
V T+++A DRD + LQ E+ GAS F L +N + LD +
Sbjct: 1288 V---TRVEALDRDSG--VNSKLQFEIMPGAS--FELFEINSDTGEVVTTTILDREIQEVF 1340
Query: 200 TFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPT 259
T +LVRD PS ++T T++ V + P F+ ++ ++ Q V T
Sbjct: 1341 TLRVLVRD----GGFPSLSSTTTILCTVEDENDHAPEFIVSSYD--IEVLENQEPEVVYT 1394
Query: 260 GHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPM 319
+ A D D G N+ + Y I GN + F I+ SG L+ R++
Sbjct: 1395 --------------VLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALDREQ 1440
Query: 320 T---FLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDA 376
L+++ D R SV + V + A P FP Y+ +V A G VV
Sbjct: 1441 ISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVL 1500
Query: 377 AAPSQPLRIQAQDPEF 392
+A + + Q F
Sbjct: 1501 SAVDKDEGLNGQTEYF 1516
Score = 56.2 bits (134), Expect = 9e-08
Identities = 88/360 (24%), Positives = 137/360 (38%), Gaps = 53/360 (14%)
Query: 78 LFLNVTPDYEEKS-LLEAQLLCQSGGTLVTQLRVFVS--VLDVNDNAPEFPFKTKEIRVE 134
LFL+ DYE S L + L VF+S V D ND++P F + I VE
Sbjct: 1006 LFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVE 1065
Query: 135 EDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYF------SLVSVNRPALRLD 188
E+ + + V + + + Y ++ G + + +LV+V+R
Sbjct: 1066 ENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSR------ 1119
Query: 189 RPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVC 248
LD P + + D NV + T + ++ + P F+ +F + +V
Sbjct: 1120 --LDRESIPTVILTVTASDQ-AVNVTDRRLRSLTAQIVILDVNDHNPTFI--SFPNAHV- 1173
Query: 249 IQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGN 308
V G ++ I A D D G N + YSI GN N TF++ SG
Sbjct: 1174 -----KEDVTVGSLVHH--------ITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGL 1220
Query: 309 LTVARSVPSPMT---FLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVAR 365
LT + M L ++ A S +TV + P F Q LY +V
Sbjct: 1221 LTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKE 1280
Query: 366 GAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRM------EGEVVLTT 419
G V R++A D + S +NS + + I + F + GEVV TT
Sbjct: 1281 NQNPGEFV---------TRVEALDRD-SGVNSKLQFEIMPGASFELFEINSDTGEVVTTT 1330
Score = 50.8 bits (120), Expect = 4e-06
Identities = 69/309 (22%), Positives = 124/309 (40%), Gaps = 41/309 (13%)
Query: 108 LRVFVSVLDVNDNAPEF----PFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYT 163
+ V+VSV D+NDN P F P K ++V E VN V T + A+D D+ + T
Sbjct: 823 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLV---TTVFAKDPDEGNNAEVT 879
Query: 164 LQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
+ +SD+F + N +R L + RP+ ++ D + V P A +
Sbjct: 880 YSVSSEDSSDHFK-IDANNGEIRTTTILSYDYRPSYRMSVIATD---QGVPPLQ-GQAVV 934
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDG-DRG 282
+ V+P S G + + ++ P+ ++ I + D +
Sbjct: 935 NIQVIP------------LSKGRAIMSQNIRHLIIPENLKPTKIM---SLIKSSDHLQQH 979
Query: 283 INQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMT----FLLLVKGQQADLARYSVT 338
N + +SI + +G F I +G+L +++ + T F ++ +L+ S
Sbjct: 980 YNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTV 1039
Query: 339 QVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSA 398
++++ P F L +V G +V A+D + S LNS
Sbjct: 1040 FLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLV---------YVFNAKDDDGSFLNSR 1090
Query: 399 ITYRITNHS 407
I Y I +H+
Sbjct: 1091 IQYYIESHN 1099
Score = 49.3 bits (116), Expect = 1e-05
Identities = 73/303 (24%), Positives = 120/303 (39%), Gaps = 35/303 (11%)
Query: 41 ENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQS 100
ENT V ++ + V + + ++ G + L+ + D E + E +L
Sbjct: 2126 ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLH-SLDREASASHELVILASD 2184
Query: 101 GGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDD 158
G L + + + VLDVNDN P F + V+E T + S + T + A DRD
Sbjct: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI---TVVSANDRDTGS 2241
Query: 159 ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHT 218
++ +F L N L L +PLD+ + T + D E H
Sbjct: 2242 HAEIIYNIISGNEKGHFYL-EENTGVLYLIKPLDYEKMTKFTLTVQASD-----AEKKHF 2295
Query: 219 ATATLVLNVVPADLRPPWFLPCTFS---------DGYVC-IQAQYHGAVPTGHI---LPS 265
+ A + ++V+ + P F+ +FS +C I A A P G + + S
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
Query: 266 PLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGN---LTVARSVPSPMTFL 322
P L G Y D D + P+ G+++ I+ ++GN LTV T
Sbjct: 2356 PCFLTHGMSY--DHDLFLIDPL-----TGDIHAKQILDYENGNKYCLTVQAKDKGDATAS 2408
Query: 323 LLV 325
L+V
Sbjct: 2409 LVV 2411
Score = 47.4 bits (111), Expect = 4e-05
Identities = 58/256 (22%), Positives = 106/256 (41%), Gaps = 32/256 (12%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTA 169
V + + D+N+ APEF K+ + + ED V ST++ + + + ++ + Y++ ++
Sbjct: 2080 VEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSI--ISG 2137
Query: 170 GASDYFSLVS---------VNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTAT 220
+ + F + + L L LD + +L D+ P ++T
Sbjct: 2138 NSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC----PPLSST 2193
Query: 221 ATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGD 280
A + + V+ + PP F YH V L S + + + A D D
Sbjct: 2194 AVISIQVLDVNDNPPNF-----------SSLSYHTHVKESTPLGSHITV----VSANDRD 2238
Query: 281 RGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP-SPMT-FLLLVKGQQADLARYSVT 338
G + IIY+I GN G F + ++G L + + + MT F L V+ A+ +S
Sbjct: 2239 TGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFSFA 2298
Query: 339 QVTVEAVAAAGSPPRF 354
V V + P+F
Sbjct: 2299 VVFVSVLDDNDHAPQF 2314
Score = 43.9 bits (102), Expect = 5e-04
Identities = 58/214 (27%), Positives = 95/214 (44%), Gaps = 33/214 (15%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQE--M 167
VFVSVLD ND+AP+F F + V E+ ++ST+ L + ++ + + +
Sbjct: 2300 VFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFL 2359
Query: 168 TAGAS---DYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLV 224
T G S D F L+ + + LD YE N + G+ ATA+LV
Sbjct: 2360 THGMSYDHDLF-LIDPLTGDIHAKQILD-YENGNKYCLTVQAKDKGD-------ATASLV 2410
Query: 225 L--NVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRG 282
+ ++ D P F Q QY +P + L+ G + A D D G
Sbjct: 2411 VWVDIEGIDEFEPIFT-----------QDQYFFTLPEKN-KDRQLI---GRVEASDADAG 2455
Query: 283 INQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP 316
I+ I+YS+ G + F ++ +GN+ + R++P
Sbjct: 2456 IDGVILYSL--GTSSPFFSVNKTNGNIYLIRALP 2487
Score = 41.6 bits (96), Expect = 0.002
Identities = 85/385 (22%), Positives = 153/385 (39%), Gaps = 62/385 (16%)
Query: 98 CQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRD-- 155
C G+ T + + V V DVNDN P ++ + ++ N T + ++A+D D
Sbjct: 1557 CSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTV---IVRADDLDLG 1613
Query: 156 KDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTF---WLLVRDTPGEN 212
+ + ++ E S+ S++ + + F + P+ + WL ++ T +
Sbjct: 1614 PNGTVVFSFAETQ-------SMFSID----KYTGEIQFQQNPSSEYFPIWLQLKVT--DQ 1660
Query: 213 VEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPG 272
P+ T T LV+++ D++ +FS Y G V + +V
Sbjct: 1661 GIPARTTTGLLVIHMEGEDVK------ISFS------HHLYKGLVTENCEAGTSIVTVKA 1708
Query: 273 PIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADL 332
+A D I + YSIF GN +G + SG LTV P + F + + Q L
Sbjct: 1709 --FAPD---SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKE--PKFLDFEVRNEVQLIVL 1761
Query: 333 ARYS----VTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQ 388
A S +V V + P F Q +Y+ +V+ + + +++ A
Sbjct: 1762 AESSGHRAYCKVAVLIQDENDNSPCFEQSIYQASVS---------ESQLYNAHVIQVFAT 1812
Query: 389 DPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGT------ 442
D + S LN I Y I + + L+ +A Y +++ + T
Sbjct: 1813 DLD-SGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPR 1871
Query: 443 --ATTVIEIQVSEQEPPSTGGGPSE 465
TTVI++QV++ + PSE
Sbjct: 1872 LSNTTVIKVQVTDINDNAPAFLPSE 1896
Score = 39.3 bits (90), Expect = 0.011
Identities = 48/199 (24%), Positives = 86/199 (43%), Gaps = 33/199 (16%)
Query: 38 EVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLL 97
+ E N +EP+ ++ G L F+ + + D+E + ++ +
Sbjct: 400 KAREPLNSSEPIF-------YRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 452
Query: 98 CQSGGT-LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQL---QAED 153
Q G + V ++V+DVNDN P F +R ++ +++ T P T L +AED
Sbjct: 453 AQLGSAPACSSTEVNITVMDVNDNHPAF------LRTSDEIRISQTTPPGTALYLARAED 506
Query: 154 RD--KDDILFYTLQEMTAGASDYFSLVSVNRP--ALRLDRPLDFYERPNMTFWLLVRDTP 209
RD ++ ++ Y++ AS + +++R L L+ L E+ +T L D
Sbjct: 507 RDSGRNGLIRYSI------ASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAED-- 558
Query: 210 GENVEPSHTATATLVLNVV 228
+ H A LVL VV
Sbjct: 559 ----QGVHPQAALLVLTVV 573
Score = 37.0 bits (84), Expect = 0.057
Identities = 32/99 (32%), Positives = 47/99 (47%), Gaps = 6/99 (6%)
Query: 67 TPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQ-SGGTLVTQLRVFVSVLDVNDNAPEFP 125
T FA + L T D+EE + E +LL Q S T+ + V VLDVNDN P F
Sbjct: 1936 TKFAIDQNTGVVVLVKTLDFEE--MTEYELLIQISDSVHYTEGALVVRVLDVNDNPPVFS 1993
Query: 126 FKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTL 164
++ V E V +V+ L A D + ++ + Y +
Sbjct: 1994 QDFYQVTVPESIPVGYSVL---TLSATDLESNENISYRI 2029
Score = 36.6 bits (83), Expect = 0.075
Identities = 69/312 (22%), Positives = 117/312 (37%), Gaps = 44/312 (14%)
Query: 37 FEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQL 96
+ +E + T P + IH G VT+ L R + L VT + ++ + +L
Sbjct: 1093 YYIESHNPGTNPFL-IHPSFGTLVTVSRLD-----RESIPTVILTVTASDQAVNVTDRRL 1146
Query: 97 LCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDK 156
L + +LDVND+ P F V+ED V S V T ++
Sbjct: 1147 ---------RSLTAQIVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRN 1196
Query: 157 DDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPS 216
+ + L +G + ++ + L PLD+ + +L D + P+
Sbjct: 1197 GKVTYSIL----SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALD----DGTPA 1248
Query: 217 HTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYA 276
+++ TL + V+ + P F Q Y +V P V R + A
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFK-----------QHLYEASVKENQ-NPGEFVTR---VEA 1293
Query: 277 EDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----RSVPSPMTFLLLVK-GQQAD 331
D D G+N + + I G F I+ D+G + R + T +LV+ G
Sbjct: 1294 LDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPS 1353
Query: 332 LARYSVTQVTVE 343
L+ + TVE
Sbjct: 1354 LSSTTTILCTVE 1365
Score = 32.7 bits (73), Expect = 1.1
Identities = 19/73 (26%), Positives = 33/73 (45%), Gaps = 2/73 (2%)
Query: 284 NQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQADLARYSVTQVT 341
++PI Y I G++ G F IHP G + + + + +L V+ Q S T+V
Sbjct: 408 SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVN 467
Query: 342 VEAVAAAGSPPRF 354
+ + + P F
Sbjct: 468 ITVMDVNDNHPAF 480
Score = 30.0 bits (66), Expect = 7.0
Identities = 23/104 (22%), Positives = 38/104 (36%), Gaps = 3/104 (2%)
Query: 66 STPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLC---QSGGTLVTQLRVFVSVLDVNDNAP 122
S F R ++L DYE ++ + G V V V D NDN+P
Sbjct: 631 SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVRVWDENDNSP 690
Query: 123 EFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQE 166
F ++VEE + T + + +L++ L +
Sbjct: 691 TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSD 734
>gi|14277682 protocadherin gamma subfamily C, 4 isoform 2 precursor
[Homo sapiens]
Length = 871
Score = 64.7 bits (156), Expect = 3e-10
Identities = 89/357 (24%), Positives = 143/357 (40%), Gaps = 56/357 (15%)
Query: 19 RPPGTMAQAQYCSVNKDIFEVEENT---NVTEPLVDIHVPEGQEV-TLGALST------- 67
R G+ A Q+CS+ D+ +V +N VT L + PE E T+ AL +
Sbjct: 323 RDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTL--PESAEPGTVVALISVQDPDSG 380
Query: 68 -------------PFAFRIQGNQLFLNVTP---DYEEKSLLEAQLLCQSGGT--LVTQLR 109
PFA + F VT D E KS + + G L T
Sbjct: 381 SNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRT 440
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDK--DDILFYTLQE- 166
+F+++ DVNDN P F ++ E+ V E+ + + L A D D + ++ Y+L E
Sbjct: 441 IFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLL---CSLAASDPDSGLNALISYSLLEP 497
Query: 167 --MTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLV 224
AS + SL + A+ R D+ + + F + RD P ++T T+
Sbjct: 498 RNRDVSASSFISL-NPQTGAVHATRSFDYEQTQTLQFEVQARD----RGNPPLSSTVTVR 552
Query: 225 LNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGIN 284
L V+ + P L G +C QA +V GH++ + A D D G N
Sbjct: 553 LFVLDLNDNAPAVLRPRARPGSLCPQA-LPPSVGAGHLITK--------VTAVDLDSGYN 603
Query: 285 QPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPS---PMTFLLLVKGQQADLARYSVT 338
+ Y + F + +G + A +P+ P +++VK + SVT
Sbjct: 604 AWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVT 660
Score = 50.1 bits (118), Expect = 7e-06
Identities = 84/373 (22%), Positives = 141/373 (37%), Gaps = 59/373 (15%)
Query: 109 RVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMT 168
R V ++DVND+AP FP R + D ++ P + E D+ ++
Sbjct: 118 RAEVEIVDVNDHAPRFP------RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYR 171
Query: 169 AGASDYFSLVSVNR------PALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATAT 222
++++F+L R P L L++PLD + L++ G N P + TA
Sbjct: 172 LSSNEHFALDVKKRSDGSLVPELLLEKPLD--REKQSDYRLVLTAVDGGN--PPRSGTAE 227
Query: 223 LVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRG 282
L ++V+ + P F ++ + + P G +L + A D D G
Sbjct: 228 LRVSVLDVNDNAPAFQQSSY-------RISVLESAPAGMVLIQ--------LNASDPDLG 272
Query: 283 INQPIIYSIFRGN----VNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQ-ADLARY 335
+ + + F G+ V F +HP +G LT+ + S + V+ + A
Sbjct: 273 PSGNVTF-YFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAME 331
Query: 336 SVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDL 395
+ V+ + + P GT+ A G VV I QDP+ S
Sbjct: 332 QHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVV---------ALISVQDPD-SGS 381
Query: 396 NSAITYRITNH------SHFRMEGEVVLTTTTLAQAGAFY----AEVEAHNTVTSGTATT 445
N ++ RI +H S FR + +V +A + Y +A N S T
Sbjct: 382 NGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTI 441
Query: 446 VIEIQVSEQEPPS 458
+ I PPS
Sbjct: 442 FLNISDVNDNPPS 454
Score = 39.7 bits (91), Expect = 0.009
Identities = 45/138 (32%), Positives = 55/138 (39%), Gaps = 13/138 (9%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGGTL----VTQLRVFVSVLDVNDNAPEFPFKTKEIR 132
+L L D E++S L GG +LRV SVLDVNDNAP F + I
Sbjct: 193 ELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV--SVLDVNDNAPAFQQSSYRIS 250
Query: 133 VEEDTKVNSTVIPETQLQAEDRD---KDDILFYTLQEMTAGASDYFSLVSVNRPALRLDR 189
V E +I QL A D D ++ FY + FSL L L
Sbjct: 251 VLESAPAGMVLI---QLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSL-HPTTGKLTLLG 306
Query: 190 PLDFYERPNMTFWLLVRD 207
PLDF F + RD
Sbjct: 307 PLDFESENYYEFDVRARD 324
>gi|11128025 protocadherin gamma subfamily C, 4 isoform 1 precursor
[Homo sapiens]
Length = 938
Score = 64.7 bits (156), Expect = 3e-10
Identities = 89/357 (24%), Positives = 143/357 (40%), Gaps = 56/357 (15%)
Query: 19 RPPGTMAQAQYCSVNKDIFEVEENT---NVTEPLVDIHVPEGQEV-TLGALST------- 67
R G+ A Q+CS+ D+ +V +N VT L + PE E T+ AL +
Sbjct: 323 RDGGSPAMEQHCSLRVDLLDVNDNAPYITVTSELGTL--PESAEPGTVVALISVQDPDSG 380
Query: 68 -------------PFAFRIQGNQLFLNVTP---DYEEKSLLEAQLLCQSGGT--LVTQLR 109
PFA + F VT D E KS + + G L T
Sbjct: 381 SNGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRT 440
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDK--DDILFYTLQE- 166
+F+++ DVNDN P F ++ E+ V E+ + + L A D D + ++ Y+L E
Sbjct: 441 IFLNISDVNDNPPSFFQRSHEVFVPENNRPGDLL---CSLAASDPDSGLNALISYSLLEP 497
Query: 167 --MTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLV 224
AS + SL + A+ R D+ + + F + RD P ++T T+
Sbjct: 498 RNRDVSASSFISL-NPQTGAVHATRSFDYEQTQTLQFEVQARD----RGNPPLSSTVTVR 552
Query: 225 LNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGIN 284
L V+ + P L G +C QA +V GH++ + A D D G N
Sbjct: 553 LFVLDLNDNAPAVLRPRARPGSLCPQA-LPPSVGAGHLITK--------VTAVDLDSGYN 603
Query: 285 QPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPS---PMTFLLLVKGQQADLARYSVT 338
+ Y + F + +G + A +P+ P +++VK + SVT
Sbjct: 604 AWVSYQLLEAPDPSLFAVSRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVT 660
Score = 50.1 bits (118), Expect = 7e-06
Identities = 84/373 (22%), Positives = 141/373 (37%), Gaps = 59/373 (15%)
Query: 109 RVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMT 168
R V ++DVND+AP FP R + D ++ P + E D+ ++
Sbjct: 118 RAEVEIVDVNDHAPRFP------RQQLDLEIGEAAPPGQRFPLEKAQDADVGSNSISSYR 171
Query: 169 AGASDYFSLVSVNR------PALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATAT 222
++++F+L R P L L++PLD + L++ G N P + TA
Sbjct: 172 LSSNEHFALDVKKRSDGSLVPELLLEKPLD--REKQSDYRLVLTAVDGGN--PPRSGTAE 227
Query: 223 LVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRG 282
L ++V+ + P F ++ + + P G +L + A D D G
Sbjct: 228 LRVSVLDVNDNAPAFQQSSY-------RISVLESAPAGMVLIQ--------LNASDPDLG 272
Query: 283 INQPIIYSIFRGN----VNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQ-ADLARY 335
+ + + F G+ V F +HP +G LT+ + S + V+ + A
Sbjct: 273 PSGNVTF-YFSGHTPDRVRNLFSLHPTTGKLTLLGPLDFESENYYEFDVRARDGGSPAME 331
Query: 336 SVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDL 395
+ V+ + + P GT+ A G VV I QDP+ S
Sbjct: 332 QHCSLRVDLLDVNDNAPYITVTSELGTLPESAEPGTVV---------ALISVQDPD-SGS 381
Query: 396 NSAITYRITNH------SHFRMEGEVVLTTTTLAQAGAFY----AEVEAHNTVTSGTATT 445
N ++ RI +H S FR + +V +A + Y +A N S T
Sbjct: 382 NGDVSLRIPDHLPFALKSAFRNQFSLVTAGPLDREAKSSYDIMVTASDAGNPPLSTHRTI 441
Query: 446 VIEIQVSEQEPPS 458
+ I PPS
Sbjct: 442 FLNISDVNDNPPS 454
Score = 39.7 bits (91), Expect = 0.009
Identities = 45/138 (32%), Positives = 55/138 (39%), Gaps = 13/138 (9%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGGTL----VTQLRVFVSVLDVNDNAPEFPFKTKEIR 132
+L L D E++S L GG +LRV SVLDVNDNAP F + I
Sbjct: 193 ELLLEKPLDREKQSDYRLVLTAVDGGNPPRSGTAELRV--SVLDVNDNAPAFQQSSYRIS 250
Query: 133 VEEDTKVNSTVIPETQLQAEDRD---KDDILFYTLQEMTAGASDYFSLVSVNRPALRLDR 189
V E +I QL A D D ++ FY + FSL L L
Sbjct: 251 VLESAPAGMVLI---QLNASDPDLGPSGNVTFYFSGHTPDRVRNLFSL-HPTTGKLTLLG 306
Query: 190 PLDFYERPNMTFWLLVRD 207
PLDF F + RD
Sbjct: 307 PLDFESENYYEFDVRARD 324
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 63.9 bits (154), Expect = 4e-10
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 24/229 (10%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
D E++ +L + G L + + VFVS++D NDN+P F + V E+ + T
Sbjct: 561 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGT 620
Query: 143 VIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFW 202
V T + D + L E D S V RP + DR ++ + TF+
Sbjct: 621 VGLITVTDPDYGDNSAVTLSILDENDDFTID--SQTGVIRPNISFDRE----KQESYTFY 674
Query: 203 LLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHI 262
+ D G V S +++A + +NVV + P F+ ++ Y + +P+ +
Sbjct: 675 VKAED--GGRV--SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELV-------LPSTN- 722
Query: 263 LPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
P +V + + A D D G+N + YSI GN F I ++GN+T+
Sbjct: 723 -PGTVVFQ---VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 767
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 15/139 (10%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGG------TLVTQLRVFVSVLDVNDNAPEFPFKTKE 130
QL + D EEK ++ + GG T + Q VSV D NDN P F E
Sbjct: 232 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQ----VSVTDTNDNHPVFKETEIE 287
Query: 131 IRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYTLQEMTAGASDYFSLVSVNRPALRLD 188
+ + E+ V ++V TQL A D D ++ + ++ + + + ++ + +
Sbjct: 288 VSIPENAPVGTSV---TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 344
Query: 189 RPLDFYERPNMTFWLLVRD 207
PLD E PN +L D
Sbjct: 345 EPLDREETPNHKLLVLASD 363
Score = 38.5 bits (88), Expect = 0.020
Identities = 87/392 (22%), Positives = 142/392 (36%), Gaps = 56/392 (14%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE + +L GG + + V V+V DVNDN P + + DT V S I
Sbjct: 348 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENI 406
Query: 145 PETQ----LQAEDRDKDD---ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP 197
P + D+D D + +T E+ FS N+ L LD+
Sbjct: 407 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS----NQFLLENAAYLDYESTK 462
Query: 198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV 257
LL D +P +A L + V + P F+ +V + ++
Sbjct: 463 EYAIKLLAADAG----KPPLNQSAMLFIKVKDENDNAP-----VFTQSFVTV------SI 507
Query: 258 PTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----R 313
P + L+ + A D D G N I Y + + F + +G LTV R
Sbjct: 508 PENNSPGIQLM----KVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDR 562
Query: 314 SVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
F +L K +VT V V + + P F Y+ V V
Sbjct: 563 EKEDKYLFTILAKDNGVPPLTSNVT-VFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 621
Query: 374 KDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-HSHFRMEGEVVLTTTTLA------QAG 426
I DP++ D NSA+T I + + F ++ + + ++ ++
Sbjct: 622 G---------LITVTDPDYGD-NSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 671
Query: 427 AFYAEVEAHNTV--TSGTATTVIEIQVSEQEP 456
FY + E V +S T+ + V++ +P
Sbjct: 672 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 703
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 48 PLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
PL+ I G+ T GA RI +L + D +E +L LV
Sbjct: 105 PLIRIEEDTGEIFTTGA-------RIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV-- 155
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
++ + D+NDNAP FP I + E++ +NS
Sbjct: 156 -KIRFLIEDINDNAPLFPATVINISIPENSAINS 188
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 63.9 bits (154), Expect = 4e-10
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 24/229 (10%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
D E++ +L + G L + + VFVS++D NDN+P F + V E+ + T
Sbjct: 561 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGT 620
Query: 143 VIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFW 202
V T + D + L E D S V RP + DR ++ + TF+
Sbjct: 621 VGLITVTDPDYGDNSAVTLSILDENDDFTID--SQTGVIRPNISFDRE----KQESYTFY 674
Query: 203 LLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHI 262
+ D G V S +++A + +NVV + P F+ ++ Y + +P+ +
Sbjct: 675 VKAED--GGRV--SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELV-------LPSTN- 722
Query: 263 LPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
P +V + + A D D G+N + YSI GN F I ++GN+T+
Sbjct: 723 -PGTVVFQ---VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 767
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 15/139 (10%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGG------TLVTQLRVFVSVLDVNDNAPEFPFKTKE 130
QL + D EEK ++ + GG T + Q VSV D NDN P F E
Sbjct: 232 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQ----VSVTDTNDNHPVFKETEIE 287
Query: 131 IRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYTLQEMTAGASDYFSLVSVNRPALRLD 188
+ + E+ V ++V TQL A D D ++ + ++ + + + ++ + +
Sbjct: 288 VSIPENAPVGTSV---TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 344
Query: 189 RPLDFYERPNMTFWLLVRD 207
PLD E PN +L D
Sbjct: 345 EPLDREETPNHKLLVLASD 363
Score = 38.5 bits (88), Expect = 0.020
Identities = 87/392 (22%), Positives = 142/392 (36%), Gaps = 56/392 (14%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE + +L GG + + V V+V DVNDN P + + DT V S I
Sbjct: 348 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENI 406
Query: 145 PETQ----LQAEDRDKDD---ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP 197
P + D+D D + +T E+ FS N+ L LD+
Sbjct: 407 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS----NQFLLENAAYLDYESTK 462
Query: 198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV 257
LL D +P +A L + V + P F+ +V + ++
Sbjct: 463 EYAIKLLAADAG----KPPLNQSAMLFIKVKDENDNAP-----VFTQSFVTV------SI 507
Query: 258 PTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----R 313
P + L+ + A D D G N I Y + + F + +G LTV R
Sbjct: 508 PENNSPGIQLM----KVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDR 562
Query: 314 SVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
F +L K +VT V V + + P F Y+ V V
Sbjct: 563 EKEDKYLFTILAKDNGVPPLTSNVT-VFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 621
Query: 374 KDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-HSHFRMEGEVVLTTTTLA------QAG 426
I DP++ D NSA+T I + + F ++ + + ++ ++
Sbjct: 622 G---------LITVTDPDYGD-NSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 671
Query: 427 AFYAEVEAHNTV--TSGTATTVIEIQVSEQEP 456
FY + E V +S T+ + V++ +P
Sbjct: 672 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 703
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 48 PLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
PL+ I G+ T GA RI +L + D +E +L LV
Sbjct: 105 PLIRIEEDTGEIFTTGA-------RIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV-- 155
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
++ + D+NDNAP FP I + E++ +NS
Sbjct: 156 -KIRFLIEDINDNAPLFPATVINISIPENSAINS 188
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 63.9 bits (154), Expect = 4e-10
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 24/229 (10%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
D E++ +L + G L + + VFVS++D NDN+P F + V E+ + T
Sbjct: 550 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGT 609
Query: 143 VIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFW 202
V T + D + L E D S V RP + DR ++ + TF+
Sbjct: 610 VGLITVTDPDYGDNSAVTLSILDENDDFTID--SQTGVIRPNISFDRE----KQESYTFY 663
Query: 203 LLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHI 262
+ D G V S +++A + +NVV + P F+ ++ Y + +P+ +
Sbjct: 664 VKAED--GGRV--SRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELV-------LPSTN- 711
Query: 263 LPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
P +V + + A D D G+N + YSI GN F I ++GN+T+
Sbjct: 712 -PGTVVFQ---VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 756
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 15/139 (10%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGG------TLVTQLRVFVSVLDVNDNAPEFPFKTKE 130
QL + D EEK ++ + GG T + Q VSV D NDN P F E
Sbjct: 221 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQ----VSVTDTNDNHPVFKETEIE 276
Query: 131 IRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYTLQEMTAGASDYFSLVSVNRPALRLD 188
+ + E+ V ++V TQL A D D ++ + ++ + + + ++ + +
Sbjct: 277 VSIPENAPVGTSV---TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 333
Query: 189 RPLDFYERPNMTFWLLVRD 207
PLD E PN +L D
Sbjct: 334 EPLDREETPNHKLLVLASD 352
Score = 38.5 bits (88), Expect = 0.020
Identities = 87/392 (22%), Positives = 142/392 (36%), Gaps = 56/392 (14%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE + +L GG + + V V+V DVNDN P + + DT V S I
Sbjct: 337 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENI 395
Query: 145 PETQ----LQAEDRDKDD---ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP 197
P + D+D D + +T E+ FS N+ L LD+
Sbjct: 396 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS----NQFLLENAAYLDYESTK 451
Query: 198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV 257
LL D +P +A L + V + P F+ +V + ++
Sbjct: 452 EYAIKLLAADAG----KPPLNQSAMLFIKVKDENDNAP-----VFTQSFVTV------SI 496
Query: 258 PTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----R 313
P + L+ + A D D G N I Y + + F + +G LTV R
Sbjct: 497 PENNSPGIQLM----KVSATDADSGPNAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDR 551
Query: 314 SVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
F +L K +VT V V + + P F Y+ V V
Sbjct: 552 EKEDKYLFTILAKDNGVPPLTSNVT-VFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTV 610
Query: 374 KDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-HSHFRMEGEVVLTTTTLA------QAG 426
I DP++ D NSA+T I + + F ++ + + ++ ++
Sbjct: 611 G---------LITVTDPDYGD-NSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 660
Query: 427 AFYAEVEAHNTV--TSGTATTVIEIQVSEQEP 456
FY + E V +S T+ + V++ +P
Sbjct: 661 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 692
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 48 PLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
PL+ I G+ T GA RI +L + D +E +L LV
Sbjct: 94 PLIRIEEDTGEIFTTGA-------RIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV-- 144
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
++ + D+NDNAP FP I + E++ +NS
Sbjct: 145 -KIRFLIEDINDNAPLFPATVINISIPENSAINS 177
>gi|7661662 protocadherin beta 5 precursor [Homo sapiens]
Length = 795
Score = 63.9 bits (154), Expect = 4e-10
Identities = 63/235 (26%), Positives = 104/235 (44%), Gaps = 35/235 (14%)
Query: 88 EKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPET 147
E +L QLL ++ V + + + D+ND+APEFP K +++ E T+ P T
Sbjct: 100 EPCILHFQLLLENP---VQFFQTDLQLTDINDHAPEFPEKEMLLKIPESTQ------PGT 150
Query: 148 QLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNR------PALRLDRPLDFYERPNMTF 201
+ DI T+Q T + +F + + NR P L LD+ LD ERP ++
Sbjct: 151 VFPLKIAQDFDIGSNTVQNYTISPNSHFHVATHNRGDGRKYPELVLDKALDREERPELSL 210
Query: 202 WLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGH 261
L D P + T T+ + V+ + P FL Q+ Y VP
Sbjct: 211 TLTALD----GGAPPRSGTTTIRIVVLDNNDNAPEFL-----------QSFYEVQVPENS 255
Query: 262 ILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGN-VNGTFIIHPDSGNLTVARSV 315
L S +V+ + A D D G + Y++F+G+ V F+I + + + R++
Sbjct: 256 PLNSLVVV----VSARDLDAGAYGSVAYALFQGDEVTQPFVIDEKTAEIRLKRAL 306
Score = 43.1 bits (100), Expect = 8e-04
Identities = 58/270 (21%), Positives = 99/270 (36%), Gaps = 44/270 (16%)
Query: 56 EGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVL 115
+G EVT PF + ++ L D+E +++ GG L + V + V+
Sbjct: 283 QGDEVT-----QPFVIDEKTAEIRLKRALDFEATPYYNVEIVATDGGGLSGKCTVAIEVV 337
Query: 116 DVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQE-----MTAG 170
DVNDNAPE T E+ TV+ + D + + ++Q +
Sbjct: 338 DVNDNAPELTMSTLSSPTPENAP--ETVVAVFSVSDPDSGDNGRMICSIQNDLPFLLKPT 395
Query: 171 ASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPA 230
++++LV+ R LD + + V D ++ H T V+ +
Sbjct: 396 LKNFYTLVT--------QRTLDRESQAEYNITITVTDMGTPRLKTEHNIT------VLVS 441
Query: 231 DLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYS 290
D+ P Y + + P HI G + A D D G N + YS
Sbjct: 442 DVNDN--APAFTQTSYTLFVRENNS--PALHI---------GSVSATDRDSGTNAQVTYS 488
Query: 291 IF-----RGNVNGTFIIHPDSGNLTVARSV 315
+ + I+ D+G+L RS+
Sbjct: 489 LLPPQNPHLRLASLVSINADNGHLFALRSL 518
Score = 43.1 bits (100), Expect = 8e-04
Identities = 73/305 (23%), Positives = 117/305 (38%), Gaps = 38/305 (12%)
Query: 83 TPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVN 140
T D E ++ + GT L T+ + V V DVNDNAP F + + V E+ N
Sbjct: 407 TLDRESQAEYNITITVTDMGTPRLKTEHNITVLVSDVNDNAPAFTQTSYTLFVREN---N 463
Query: 141 STVIPETQLQAEDRDK--DDILFYTLQEMTAGASDYFSLVSVNRPALRLD--RPLDFYER 196
S + + A DRD + + Y+L SLVS+N L R LD+
Sbjct: 464 SPALHIGSVSATDRDSGTNAQVTYSLLPPQNPHLRLASLVSINADNGHLFALRSLDYEAL 523
Query: 197 PNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGA 256
F + D P+ ++ A + + V+ A+ P+ L + C + A
Sbjct: 524 QAFEFRVGATDRGS----PALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAA 579
Query: 257 VPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVP 316
P G+++ + A DGD G N + Y + + G F + +G + AR +
Sbjct: 580 EP-GYLVTK--------VVAVDGDSGQNAWLSYQLLKATEPGLFSMWAHNGEVRTARLL- 629
Query: 317 SPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDA 376
+ D A++ + V V G PPR + G +
Sbjct: 630 -----------SERDAAKHRL----VVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPE 674
Query: 377 AAPSQ 381
AAP+Q
Sbjct: 675 AAPAQ 679
Score = 41.6 bits (96), Expect = 0.002
Identities = 41/140 (29%), Positives = 61/140 (43%), Gaps = 13/140 (9%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGGTL----VTQLRVFVSVLDVNDNAPEFPFKTKEIR 132
+L L+ D EE+ L L GG T +R+ V LD NDNAPEF E++
Sbjct: 193 ELVLDKALDREERPELSLTLTALDGGAPPRSGTTTIRIVV--LDNNDNAPEFLQSFYEVQ 250
Query: 133 VEEDTKVNSTVIPETQLQAEDRDKD--DILFYTLQEMTAGASDYFSLVSVNRPALRLDRP 190
V E++ +NS V+ + A D D + Y L + + ++ +RL R
Sbjct: 251 VPENSPLNSLVV---VVSARDLDAGAYGSVAYALFQGDEVTQPF--VIDEKTAEIRLKRA 305
Query: 191 LDFYERPNMTFWLLVRDTPG 210
LDF P ++ D G
Sbjct: 306 LDFEATPYYNVEIVATDGGG 325
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 63.5 bits (153), Expect = 6e-10
Identities = 82/342 (23%), Positives = 143/342 (41%), Gaps = 49/342 (14%)
Query: 69 FAFRIQGNQLFLNVTPDYEEKSL----LEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEF 124
F F+I + ++ V + + + + + + + + V ++VLDVNDN P F
Sbjct: 628 FPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVF 687
Query: 125 PFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAG-ASDYFSLVSVNRP 183
T E+R+ ED V S+V+ LQA DRD + ++ Y ++T G + F+L S
Sbjct: 688 TQPTYELRLNEDAAVGSSVL---TLQARDRDANSVITY---QLTGGNTRNRFALSSQRGG 741
Query: 184 AL-RLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTF 242
L L PLD+ + + L V + G + + TA +++NV A+ P F
Sbjct: 742 GLITLALPLDY--KQEQQYVLAVTASDG-----TRSHTAHVLINVTDANTHRP-----VF 789
Query: 243 SDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFII 302
+ + V T + A D D G N I Y I + F I
Sbjct: 790 QSSHYTVSVSEDRPVGTS----------IATLSANDEDTGENARITYVI--QDPVPQFRI 837
Query: 303 HPDSGNLTVARSV--PSPMTFLLLVKGQQADLARYS-VTQVTVEAVAAAGSPPRFPQRLY 359
PDSG + + + + + L + Q + + S T + + + A + P+F Y
Sbjct: 838 DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFY 897
Query: 360 RGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITY 401
+G+ + +DA + L++ A D + S N + Y
Sbjct: 898 QGS---------IFEDAPPSTSILQVSATDRD-SGPNGRLLY 929
Score = 57.8 bits (138), Expect = 3e-08
Identities = 97/400 (24%), Positives = 155/400 (38%), Gaps = 63/400 (15%)
Query: 87 EEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPE 146
E + L+EA ++ G L V++ V D NDN P+F + ++V ED +N+ V+
Sbjct: 422 EYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL-- 479
Query: 147 TQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVR 206
++QA DRD+ ++ + F L S++ L + PLDF + + + +
Sbjct: 480 -RVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLS-GILDVINPLDFEDVQKYSLSIKAQ 537
Query: 207 DTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSP 266
D P ++ + + V+ + P F+ F QA VP G+ P
Sbjct: 538 D---GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPF-------QATVLENVPLGY----P 583
Query: 267 LVLRPGPIYAEDGDRGINQPIIY------SIFRGNVNG-----------TFIIHPDSGNL 309
+V I A D D G N + Y S F G + F IH SG +
Sbjct: 584 VV----HIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
Query: 310 TVARSVPSPMTFLLLVKGQQADLA---RYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARG 366
TV + + D S T V++ + + P F Q Y +
Sbjct: 640 TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-- 697
Query: 367 AGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRIT---NHSHFRMEGEVVLTTTTLA 423
+DAA S L +QA+D D NS ITY++T + F + + TLA
Sbjct: 698 -------EDAAVGSSVLTLQARD---RDANSVITYQLTGGNTRNRFALSSQRGGGLITLA 747
Query: 424 ------QAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPP 457
Q + V A + S TA +I + + P
Sbjct: 748 LPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRP 787
Score = 52.0 bits (123), Expect = 2e-06
Identities = 81/300 (27%), Positives = 119/300 (39%), Gaps = 36/300 (12%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTA 169
+ V V D ND++P F RV E+ +V V+ ++A DRD I +
Sbjct: 339 ITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLT---IRASDRDSP-INANLRYRVLG 394
Query: 170 GASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVP 229
GA D F L + + + LD E + D G N P +ATAT+ + V
Sbjct: 395 GAWDVFQL-NESSGVVSTRAVLDREEAAEYQLLVEANDQ-GRNPGPL-SATATVYIEVED 451
Query: 230 ADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIY 289
+ P FS+ +Q + T VLR + A D D+G N I Y
Sbjct: 452 ENDNYP-----QFSEQNYVVQVPEDVGLNTA-------VLR---VQATDRDQGQNAAIHY 496
Query: 290 SIFRGNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQADLARY--SVTQVTVEAV 345
SI GNV G F +H SG L V + + L +K Q S V+V+ +
Sbjct: 497 SILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVL 556
Query: 346 AAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITN 405
+ P F ++ TV G V + IQA D + S N+ + YR+ +
Sbjct: 557 DVNDNEPIFVSSPFQATVLENVPLGYPV---------VHIQAVDAD-SGENARLHYRLVD 606
Score = 46.2 bits (108), Expect = 9e-05
Identities = 58/212 (27%), Positives = 93/212 (43%), Gaps = 24/212 (11%)
Query: 104 LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYT 163
L + + V++LD+NDNAP F E+ VEE+ V S V +++A D D+
Sbjct: 979 LSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVV---AKIRANDPDEGPNAQIM 1035
Query: 164 LQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
Q + +F L +N LR LDF R + L+V+ T V + AT+
Sbjct: 1036 YQIVEGDMRHFFQLDLLNGD-LRAMVELDFEVR--REYVLVVQATSAPLV-----SRATV 1087
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGI 283
+ +V + PP LP F + + PTG I G I A D D +
Sbjct: 1088 HILLVDQNDNPP-VLP-DFQILFNNYVTNKSNSFPTGVI---------GCIPAHDPD--V 1134
Query: 284 NQPIIYSIFRGNVNGTFIIHPDSGNLTVARSV 315
+ + Y+ +GN ++ P +G L ++R +
Sbjct: 1135 SDSLNYTFVQGNELRLLLLDPATGELQLSRDL 1166
>gi|11056065 protocadherin gamma subfamily A, 6 isoform 1 precursor
[Homo sapiens]
Length = 932
Score = 63.5 bits (153), Expect = 6e-10
Identities = 82/340 (24%), Positives = 136/340 (40%), Gaps = 54/340 (15%)
Query: 20 PPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAF-RIQGN-- 76
PPGT+ +F+V + + LV +P S PF + GN
Sbjct: 361 PPGTVIA---------LFQVFDRDSGLNGLVTCSIPR---------SLPFELEKSVGNYY 402
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVE 134
+L N D EE L + GT L T+ + ++V D NDN P FP + + V
Sbjct: 403 RLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVL 462
Query: 135 EDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPA--LRLDRPLD 192
E+ +++ L D D++ + Y+L E T + S VS+N L R D
Sbjct: 463 ENNPRGASIFSVNALD-PDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFD 521
Query: 193 FYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQ 252
+ + ++ W+ D+ G+ S+ + + VL+ D P P +DG ++
Sbjct: 522 YEQLRDLQLWVTASDS-GDPPLSSNVSLSLFVLD--QNDNAPEILYPALPTDGSTGVELA 578
Query: 253 YHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA 312
A P G+++ + A D D G N + Y + + + G F + +G + A
Sbjct: 579 PRSAEP-GYLVTK--------VVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA 629
Query: 313 RSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPP 352
R++ L R ++ Q V AV G PP
Sbjct: 630 RAL----------------LDRDALKQSLVVAVQDHGQPP 653
Score = 44.7 bits (104), Expect = 3e-04
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 45/254 (17%)
Query: 22 GTMAQAQYCSVNKDIFEVEENTNV-TEPLVDIHVPEGQEVTLGALSTPFAFRIQG----- 75
G ++ + + +V +NT + T+P+ + VPE V L+ + +G
Sbjct: 218 GDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEV 277
Query: 76 -----------NQLF-LNVTP---------DYEEKSLLEAQLLCQSGGTLVTQLRVFVSV 114
+Q+F LNV DYE+ S E + + G L + +V +++
Sbjct: 278 TYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITI 337
Query: 115 LDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQ-----EMTA 169
LDVNDN PE T R ++ TVI Q+ D + ++ ++ E+
Sbjct: 338 LDVNDNVPEV-VVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEK 396
Query: 170 GASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVP 229
+Y+ LV+ LDR F N+T + TP P T T + LNV
Sbjct: 397 SVGNYYRLVT----NAALDREEVFLY--NITVTATDKGTP-----PLSTET-IISLNVAD 444
Query: 230 ADLRPPWFLPCTFS 243
+ PP F ++S
Sbjct: 445 TNDNPPTFPHSSYS 458
Score = 40.0 bits (92), Expect = 0.007
Identities = 78/378 (20%), Positives = 145/378 (38%), Gaps = 74/378 (19%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTA 169
V V ++D+NDN P F ++ E + K+ P ++ + D+ +LQ
Sbjct: 119 VEVEIVDINDNTPRF------LKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKL 172
Query: 170 GASDYFSLVSVNR------PALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
+ +FS+ + P L L+ LD R + LV T + +P ++ A +
Sbjct: 173 SGNSHFSVDVQSEAHGPKYPELVLEGTLD---REGEAVYRLVL-TAMDGGDPVRSSVAQI 228
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGI 283
++ V+ + P F Q Y +VP + +P++ + A D D G+
Sbjct: 229 LVTVLDVNDNTPMF-----------TQPVYRVSVPENLPVGTPVL----AVTATDQDEGV 273
Query: 284 NQPIIYSIFR--GNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQA----DLARY 335
+ + YS + ++ F ++ +G ++ + ++ + L V+ + D A+
Sbjct: 274 HGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKV 333
Query: 336 SVTQVTV-----EAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDP 390
+T + V E V +GS T+A A G V+ Q D
Sbjct: 334 LITILDVNDNVPEVVVTSGS----------RTIAESAPPGTVI---------ALFQVFDR 374
Query: 391 EFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGT-------- 442
+ S LN +T I F +E V + A EV +N + T
Sbjct: 375 D-SGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLS 433
Query: 443 ATTVIEIQVSE--QEPPS 458
T+I + V++ PP+
Sbjct: 434 TETIISLNVADTNDNPPT 451
>gi|14196474 protocadherin gamma subfamily A, 6 isoform 2 precursor
[Homo sapiens]
Length = 818
Score = 63.5 bits (153), Expect = 6e-10
Identities = 82/340 (24%), Positives = 136/340 (40%), Gaps = 54/340 (15%)
Query: 20 PPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAF-RIQGN-- 76
PPGT+ +F+V + + LV +P S PF + GN
Sbjct: 361 PPGTVIA---------LFQVFDRDSGLNGLVTCSIPR---------SLPFELEKSVGNYY 402
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVE 134
+L N D EE L + GT L T+ + ++V D NDN P FP + + V
Sbjct: 403 RLVTNAALDREEVFLYNITVTATDKGTPPLSTETIISLNVADTNDNPPTFPHSSYSVYVL 462
Query: 135 EDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPA--LRLDRPLD 192
E+ +++ L D D++ + Y+L E T + S VS+N L R D
Sbjct: 463 ENNPRGASIFSVNALD-PDVDQNAQVSYSLAEDTLQGAPLSSYVSINSDTGILYALRSFD 521
Query: 193 FYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQ 252
+ + ++ W+ D+ G+ S+ + + VL+ D P P +DG ++
Sbjct: 522 YEQLRDLQLWVTASDS-GDPPLSSNVSLSLFVLD--QNDNAPEILYPALPTDGSTGVELA 578
Query: 253 YHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA 312
A P G+++ + A D D G N + Y + + + G F + +G + A
Sbjct: 579 PRSAEP-GYLVTK--------VVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTA 629
Query: 313 RSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPP 352
R++ L R ++ Q V AV G PP
Sbjct: 630 RAL----------------LDRDALKQSLVVAVQDHGQPP 653
Score = 44.7 bits (104), Expect = 3e-04
Identities = 62/254 (24%), Positives = 103/254 (40%), Gaps = 45/254 (17%)
Query: 22 GTMAQAQYCSVNKDIFEVEENTNV-TEPLVDIHVPEGQEVTLGALSTPFAFRIQG----- 75
G ++ + + +V +NT + T+P+ + VPE V L+ + +G
Sbjct: 218 GDPVRSSVAQILVTVLDVNDNTPMFTQPVYRVSVPENLPVGTPVLAVTATDQDEGVHGEV 277
Query: 76 -----------NQLF-LNVTP---------DYEEKSLLEAQLLCQSGGTLVTQLRVFVSV 114
+Q+F LNV DYE+ S E + + G L + +V +++
Sbjct: 278 TYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKVLITI 337
Query: 115 LDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQ-----EMTA 169
LDVNDN PE T R ++ TVI Q+ D + ++ ++ E+
Sbjct: 338 LDVNDNVPEV-VVTSGSRTIAESAPPGTVIALFQVFDRDSGLNGLVTCSIPRSLPFELEK 396
Query: 170 GASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVP 229
+Y+ LV+ LDR F N+T + TP P T T + LNV
Sbjct: 397 SVGNYYRLVT----NAALDREEVFLY--NITVTATDKGTP-----PLSTET-IISLNVAD 444
Query: 230 ADLRPPWFLPCTFS 243
+ PP F ++S
Sbjct: 445 TNDNPPTFPHSSYS 458
Score = 40.0 bits (92), Expect = 0.007
Identities = 78/378 (20%), Positives = 145/378 (38%), Gaps = 74/378 (19%)
Query: 110 VFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTA 169
V V ++D+NDN P F ++ E + K+ P ++ + D+ +LQ
Sbjct: 119 VEVEIVDINDNTPRF------LKEELEVKILENAAPSSRFPLMEVYDPDVGMNSLQGFKL 172
Query: 170 GASDYFSLVSVNR------PALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATL 223
+ +FS+ + P L L+ LD R + LV T + +P ++ A +
Sbjct: 173 SGNSHFSVDVQSEAHGPKYPELVLEGTLD---REGEAVYRLVL-TAMDGGDPVRSSVAQI 228
Query: 224 VLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGI 283
++ V+ + P F Q Y +VP + +P++ + A D D G+
Sbjct: 229 LVTVLDVNDNTPMF-----------TQPVYRVSVPENLPVGTPVL----AVTATDQDEGV 273
Query: 284 NQPIIYSIFR--GNVNGTFIIHPDSGNLTVARSV--PSPMTFLLLVKGQQA----DLARY 335
+ + YS + ++ F ++ +G ++ + ++ + L V+ + D A+
Sbjct: 274 HGEVTYSFVKITEKISQIFCLNVLTGEISTSANLDYEDSSFYELGVEARDGPGLRDRAKV 333
Query: 336 SVTQVTV-----EAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDP 390
+T + V E V +GS T+A A G V+ Q D
Sbjct: 334 LITILDVNDNVPEVVVTSGS----------RTIAESAPPGTVI---------ALFQVFDR 374
Query: 391 EFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGT-------- 442
+ S LN +T I F +E V + A EV +N + T
Sbjct: 375 D-SGLNGLVTCSIPRSLPFELEKSVGNYYRLVTNAALDREEVFLYNITVTATDKGTPPLS 433
Query: 443 ATTVIEIQVSE--QEPPS 458
T+I + V++ PP+
Sbjct: 434 TETIISLNVADTNDNPPT 451
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 62.4 bits (150), Expect = 1e-09
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 26/230 (11%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
D E++ +L + G L + + VFVS++D NDN+P F V E+ + T
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGT 588
Query: 143 VIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFW 202
V T + D + L E D S V RP + DR ++ + TF+
Sbjct: 589 VGLITVTDPDYGDNSAVTLSILDENDDFTID--SQTGVIRPNISFDRE----KQESYTFY 642
Query: 203 LLVRDTPGENVEPSHTATATLVLNVVPA-DLRPPWFLPCTFSDGYVCIQAQYHGAVPTGH 261
+ D G V S +++A + +NVV D +P + +P + Y +P+ +
Sbjct: 643 VKAED--GGRV--SRSSSAKVTINVVDVNDNKPVFIVPPS--------NCSYELVLPSTN 690
Query: 262 ILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
P +V + + A D D G+N + YSI GN F I ++GN+T+
Sbjct: 691 --PGTVVFQ---VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 15/139 (10%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGG------TLVTQLRVFVSVLDVNDNAPEFPFKTKE 130
QL + D EEK ++ + GG T + Q VSV D NDN P F E
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQ----VSVTDTNDNHPVFKETEIE 255
Query: 131 IRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYTLQEMTAGASDYFSLVSVNRPALRLD 188
+ + E+ V ++V TQL A D D ++ + ++ + + + ++ + +
Sbjct: 256 VSIPENAPVGTSV---TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 189 RPLDFYERPNMTFWLLVRD 207
PLD E PN +L D
Sbjct: 313 EPLDREETPNHKLLVLASD 331
Score = 37.7 bits (86), Expect = 0.033
Identities = 88/392 (22%), Positives = 143/392 (36%), Gaps = 56/392 (14%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE + +L GG + + V V+V DVNDN P + + DT V S I
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENI 374
Query: 145 PETQ----LQAEDRDKDD---ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP 197
P + D+D D + +T E+ FS N+ L LD+
Sbjct: 375 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS----NQFLLETAAYLDYESTK 430
Query: 198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV 257
LL D +P +A L + V + P F+ +V + ++
Sbjct: 431 EYAIKLLAADAG----KPPLNQSAMLFIKVKDENDNAP-----VFTQSFVTV------SI 475
Query: 258 PTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----R 313
P + SP ++ + A D D G N I Y + + F + +G LTV R
Sbjct: 476 PENN---SP-GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 314 SVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
F +L K +VT V V + + P F Y V V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNVT-VFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 374 KDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-HSHFRMEGEVVLTTTTLA------QAG 426
I DP++ D NSA+T I + + F ++ + + ++ ++
Sbjct: 590 G---------LITVTDPDYGD-NSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 639
Query: 427 AFYAEVEAHNTV--TSGTATTVIEIQVSEQEP 456
FY + E V +S T+ + V++ +P
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 48 PLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
PL+ I G+ T GA RI +L + D +E +L LV
Sbjct: 73 PLIRIEEDTGEIFTTGA-------RIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV-- 123
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
++ + D+NDNAP FP I + E++ +NS
Sbjct: 124 -KIRFLIEDINDNAPLFPATVINISIPENSAINS 156
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 62.4 bits (150), Expect = 1e-09
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 26/230 (11%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
D E++ +L + G L + + VFVS++D NDN+P F V E+ + T
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGT 588
Query: 143 VIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFW 202
V T + D + L E D S V RP + DR ++ + TF+
Sbjct: 589 VGLITVTDPDYGDNSAVTLSILDENDDFTID--SQTGVIRPNISFDRE----KQESYTFY 642
Query: 203 LLVRDTPGENVEPSHTATATLVLNVVPA-DLRPPWFLPCTFSDGYVCIQAQYHGAVPTGH 261
+ D G V S +++A + +NVV D +P + +P + Y +P+ +
Sbjct: 643 VKAED--GGRV--SRSSSAKVTINVVDVNDNKPVFIVPPS--------NCSYELVLPSTN 690
Query: 262 ILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
P +V + + A D D G+N + YSI GN F I ++GN+T+
Sbjct: 691 --PGTVVFQ---VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 15/139 (10%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGG------TLVTQLRVFVSVLDVNDNAPEFPFKTKE 130
QL + D EEK ++ + GG T + Q VSV D NDN P F E
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQ----VSVTDTNDNHPVFKETEIE 255
Query: 131 IRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYTLQEMTAGASDYFSLVSVNRPALRLD 188
+ + E+ V ++V TQL A D D ++ + ++ + + + ++ + +
Sbjct: 256 VSIPENAPVGTSV---TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 189 RPLDFYERPNMTFWLLVRD 207
PLD E PN +L D
Sbjct: 313 EPLDREETPNHKLLVLASD 331
Score = 37.7 bits (86), Expect = 0.033
Identities = 88/392 (22%), Positives = 143/392 (36%), Gaps = 56/392 (14%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE + +L GG + + V V+V DVNDN P + + DT V S I
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENI 374
Query: 145 PETQ----LQAEDRDKDD---ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP 197
P + D+D D + +T E+ FS N+ L LD+
Sbjct: 375 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS----NQFLLETAAYLDYESTK 430
Query: 198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV 257
LL D +P +A L + V + P F+ +V + ++
Sbjct: 431 EYAIKLLAADAG----KPPLNQSAMLFIKVKDENDNAP-----VFTQSFVTV------SI 475
Query: 258 PTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----R 313
P + SP ++ + A D D G N I Y + + F + +G LTV R
Sbjct: 476 PENN---SP-GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 314 SVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
F +L K +VT V V + + P F Y V V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNVT-VFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 374 KDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-HSHFRMEGEVVLTTTTLA------QAG 426
I DP++ D NSA+T I + + F ++ + + ++ ++
Sbjct: 590 G---------LITVTDPDYGD-NSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 639
Query: 427 AFYAEVEAHNTV--TSGTATTVIEIQVSEQEP 456
FY + E V +S T+ + V++ +P
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 48 PLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
PL+ I G+ T GA RI +L + D +E +L LV
Sbjct: 73 PLIRIEEDTGEIFTTGA-------RIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV-- 123
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
++ + D+NDNAP FP I + E++ +NS
Sbjct: 124 -KIRFLIEDINDNAPLFPATVINISIPENSAINS 156
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 62.4 bits (150), Expect = 1e-09
Identities = 62/230 (26%), Positives = 102/230 (44%), Gaps = 26/230 (11%)
Query: 85 DYEEKSLLEAQLLCQSGGT--LVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNST 142
D E++ +L + G L + + VFVS++D NDN+P F V E+ + T
Sbjct: 529 DREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGT 588
Query: 143 VIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFW 202
V T + D + L E D S V RP + DR ++ + TF+
Sbjct: 589 VGLITVTDPDYGDNSAVTLSILDENDDFTID--SQTGVIRPNISFDRE----KQESYTFY 642
Query: 203 LLVRDTPGENVEPSHTATATLVLNVVPA-DLRPPWFLPCTFSDGYVCIQAQYHGAVPTGH 261
+ D G V S +++A + +NVV D +P + +P + Y +P+ +
Sbjct: 643 VKAED--GGRV--SRSSSAKVTINVVDVNDNKPVFIVPPS--------NCSYELVLPSTN 690
Query: 262 ILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTV 311
P +V + + A D D G+N + YSI GN F I ++GN+T+
Sbjct: 691 --PGTVVFQ---VIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITL 735
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/139 (26%), Positives = 60/139 (43%), Gaps = 15/139 (10%)
Query: 77 QLFLNVTPDYEEKSLLEAQLLCQSGG------TLVTQLRVFVSVLDVNDNAPEFPFKTKE 130
QL + D EEK ++ + GG T + Q VSV D NDN P F E
Sbjct: 200 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQ----VSVTDTNDNHPVFKETEIE 255
Query: 131 IRVEEDTKVNSTVIPETQLQAEDRD--KDDILFYTLQEMTAGASDYFSLVSVNRPALRLD 188
+ + E+ V ++V TQL A D D ++ + ++ + + + ++ + +
Sbjct: 256 VSIPENAPVGTSV---TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIK 312
Query: 189 RPLDFYERPNMTFWLLVRD 207
PLD E PN +L D
Sbjct: 313 EPLDREETPNHKLLVLASD 331
Score = 37.7 bits (86), Expect = 0.033
Identities = 88/392 (22%), Positives = 143/392 (36%), Gaps = 56/392 (14%)
Query: 85 DYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVI 144
D EE + +L GG + + V V+V DVNDN P + + DT V S I
Sbjct: 316 DREETPNHKLLVLASDGGLMPARAMVLVNVTDVNDNVPSIDIR-YIVNPVNDTVVLSENI 374
Query: 145 PETQ----LQAEDRDKDD---ILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERP 197
P + D+D D + +T E+ FS N+ L LD+
Sbjct: 375 PLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFS----NQFLLETAAYLDYESTK 430
Query: 198 NMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAV 257
LL D +P +A L + V + P F+ +V + ++
Sbjct: 431 EYAIKLLAADAG----KPPLNQSAMLFIKVKDENDNAP-----VFTQSFVTV------SI 475
Query: 258 PTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVA----R 313
P + SP ++ + A D D G N I Y + + F + +G LTV R
Sbjct: 476 PENN---SP-GIQLTKVSAMDADSGPNAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDR 530
Query: 314 SVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVV 373
F +L K +VT V V + + P F Y V V
Sbjct: 531 EKEDKYLFTILAKDNGVPPLTSNVT-VFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTV 589
Query: 374 KDAAAPSQPLRIQAQDPEFSDLNSAITYRITN-HSHFRMEGEVVLTTTTLA------QAG 426
I DP++ D NSA+T I + + F ++ + + ++ ++
Sbjct: 590 G---------LITVTDPDYGD-NSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESY 639
Query: 427 AFYAEVEAHNTV--TSGTATTVIEIQVSEQEP 456
FY + E V +S T+ + V++ +P
Sbjct: 640 TFYVKAEDGGRVSRSSSAKVTINVVDVNDNKP 671
Score = 32.3 bits (72), Expect = 1.4
Identities = 27/94 (28%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 48 PLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQ 107
PL+ I G+ T GA RI +L + D +E +L LV
Sbjct: 73 PLIRIEEDTGEIFTTGA-------RIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV-- 123
Query: 108 LRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNS 141
++ + D+NDNAP FP I + E++ +NS
Sbjct: 124 -KIRFLIEDINDNAPLFPATVINISIPENSAINS 156
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,433,321
Number of Sequences: 37866
Number of extensions: 1824334
Number of successful extensions: 28971
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 516
Number of HSP's successfully gapped in prelim test: 769
Number of HSP's that attempted gapping in prelim test: 15456
Number of HSP's gapped (non-prelim): 9848
length of query: 651
length of database: 18,247,518
effective HSP length: 109
effective length of query: 542
effective length of database: 14,120,124
effective search space: 7653107208
effective search space used: 7653107208
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.