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Search of human proteins with 166295173
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166295173 kin of IRRE like [Homo sapiens]
(757 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166295173 kin of IRRE like [Homo sapiens] 1536 0.0
gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens] 616 e-176
gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens] 571 e-162
gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens] 437 e-122
gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens] 435 e-122
gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens] 392 e-109
gi|4758822 nephrin precursor [Homo sapiens] 114 3e-25
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 107 5e-23
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 106 7e-23
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 106 7e-23
gi|21686977 cell adhesion molecule 4 [Homo sapiens] 104 3e-22
gi|110349719 titin isoform N2-A [Homo sapiens] 102 1e-21
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 100 5e-21
gi|118572606 hemicentin 1 [Homo sapiens] 99 1e-20
gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens] 96 9e-20
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 94 4e-19
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 94 4e-19
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 94 4e-19
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 91 4e-18
gi|71274107 melanoma cell adhesion molecule [Homo sapiens] 87 6e-17
gi|19743806 roundabout 1 isoform b [Homo sapiens] 86 1e-16
gi|4506569 roundabout 1 isoform a [Homo sapiens] 86 1e-16
gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens] 84 4e-16
gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens] 84 5e-16
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 84 6e-16
gi|222352127 sidekick 2 [Homo sapiens] 82 1e-15
gi|224994173 roundabout 1 isoform d [Homo sapiens] 82 2e-15
gi|224994171 roundabout 1 isoform c [Homo sapiens] 82 2e-15
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 82 2e-15
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 82 2e-15
>gi|166295173 kin of IRRE like [Homo sapiens]
Length = 757
Score = 1536 bits (3978), Expect = 0.0
Identities = 757/757 (100%), Positives = 757/757 (100%)
Query: 1 MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLAL 60
MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLAL
Sbjct: 1 MLSLLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLAL 60
Query: 61 GMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPP 120
GMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPP
Sbjct: 61 GMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPP 120
Query: 121 EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET 180
EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET
Sbjct: 121 EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET 180
Query: 181 TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV 240
TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV
Sbjct: 181 TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV 240
Query: 241 VFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVST 300
VFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVST
Sbjct: 241 VFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVST 300
Query: 301 LVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS 360
LVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS
Sbjct: 301 LVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS 360
Query: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPP 420
VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPP
Sbjct: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPP 420
Query: 421 PDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGP 480
PDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGP
Sbjct: 421 PDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGP 480
Query: 481 GTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV 540
GTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV
Sbjct: 481 GTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKV 540
Query: 541 ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKD 600
ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKD
Sbjct: 541 ETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKD 600
Query: 601 PTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASD 660
PTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASD
Sbjct: 601 PTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYSRGPASD 660
Query: 661 YGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTP 720
YGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTP
Sbjct: 661 YGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTP 720
Query: 721 YEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV 757
YEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
Sbjct: 721 YEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV 757
>gi|26006461 kin of IRRE like 3 isoform 1 [Homo sapiens]
Length = 778
Score = 616 bits (1588), Expect = e-176
Identities = 340/760 (44%), Positives = 459/760 (60%), Gaps = 42/760 (5%)
Query: 16 SQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVV 75
++G FSQ+P DQ VV+GQ L C + Y G V W KDGLALG+G+ L ++P+Y VV
Sbjct: 43 NEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV 102
Query: 76 GSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQA 135
G+ +G+++L+I AEL DDA YECQA +AA+RSR A+LTVL+PP+D I GGPVI L+A
Sbjct: 103 GNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA 162
Query: 136 GTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIG 195
G P NLTC A NAKPAA+IIW R G GA S LL+DGKRE+ VS L I+P D++ G
Sbjct: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
Query: 196 RVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGY 255
+ CR+ N+AIP GKETS+ +D+ HPP V LS+EPQ V E V F C A ANP + Y
Sbjct: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQY 282
Query: 256 RWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPK 315
RWAK G +I++A Y T VDY++F+EPVSCEV N +GSTN+S V+V+F PR+ +P+
Sbjct: 283 RWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQ 342
Query: 316 PTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIV 375
D+GSD +C W GNP LT+ W K+ S +VLSN L LKSV Q DAG Y CRA+V
Sbjct: 343 SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV 402
Query: 376 PRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEV 435
PR+G EREV L VNGPPIISS Q+A+ G+ G+++CFI STPPPDRIAW+WKEN LE
Sbjct: 403 PRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLES 462
Query: 436 GTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEER----- 490
GT RYTVE ++ GV+STLTI+N++ ADFQT YNCTAWNSFG T II+L+E+
Sbjct: 463 GTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMK 522
Query: 491 -------EVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETV 543
E +P+ +I G +GA + + +V F R + + K V K DI+VE V
Sbjct: 523 SGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIV 582
Query: 544 NREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTN 603
++EP + E T R F+ D LKQ L + +E +KDPTN
Sbjct: 583 HKEPASGREGEEHSTIKQLMMDR------GEFQQDSVLKQ-LEVLKEEEKEFQNLKDPTN 635
Query: 604 GYYNVRAHEDRPSSRAVLYADYRAPGPARFDGRPSSRLSHSSGYAQLNTYS----RGPAS 659
GYY+V ++ S+ + + + D RP+ + +G + N YS +G
Sbjct: 636 GYYSVNTFKEHHSTPTISLSSCQP------DLRPAGKQRVPTGMSFTNIYSTLSGQGRLY 689
Query: 660 DYGPEPTPPGPAAPAGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERT 719
DYG G ++S E +F ++ + + + S ++
Sbjct: 690 DYGQR-------FVLGMGSSSIELCE--REFQRGSLSDSSSFLDTQC--DSSVSSSGKQD 738
Query: 720 PYEAYDPIGKYATAT--RFSYTSQHSDYGQRFQQRMQTHV 757
Y +D K + ++ +SQ+SD + Q+RMQTHV
Sbjct: 739 GYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV 778
>gi|239787787 kin of IRRE like 3 isoform 2 [Homo sapiens]
Length = 600
Score = 571 bits (1471), Expect = e-162
Identities = 281/524 (53%), Positives = 361/524 (68%), Gaps = 12/524 (2%)
Query: 16 SQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVV 75
++G FSQ+P DQ VV+GQ L C + Y G V W KDGLALG+G+ L ++P+Y VV
Sbjct: 43 NEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV 102
Query: 76 GSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQA 135
G+ +G+++L+I AEL DDA YECQA +AA+RSR A+LTVL+PP+D I GGPVI L+A
Sbjct: 103 GNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRA 162
Query: 136 GTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIG 195
G P NLTC A NAKPAA+IIW R G GA S LL+DGKRE+ VS L I+P D++ G
Sbjct: 163 GDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENG 222
Query: 196 RVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGY 255
+ CR+ N+AIP GKETS+ +D+ HPP V LS+EPQ V E V F C A ANP + Y
Sbjct: 223 QSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQY 282
Query: 256 RWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPK 315
RWAK G +I++A Y T VDY++F+EPVSCEV N +GSTN+S V+V+F PR+ +P+
Sbjct: 283 RWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQ 342
Query: 316 PTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIV 375
D+GSD +C W GNP LT+ W K+ S +VLSN L LKSV Q DAG Y CRA+V
Sbjct: 343 SLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVV 402
Query: 376 PRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEV 435
PR+G EREV L VNGPPIISS Q+A+ G+ G+++CFI STPPPDRIAW+WKEN LE
Sbjct: 403 PRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLES 462
Query: 436 GTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEER----- 490
GT RYTVE ++ GV+STLTI+N++ ADFQT YNCTAWNSFG T II+L+E+
Sbjct: 463 GTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMK 522
Query: 491 -------EVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGS 527
E +P+ +I G +GA + + +V F R + S
Sbjct: 523 SGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRS 566
>gi|145275170 kin of IRRE-like 2 isoform a [Homo sapiens]
Length = 633
Score = 437 bits (1123), Expect = e-122
Identities = 244/624 (39%), Positives = 342/624 (54%), Gaps = 28/624 (4%)
Query: 18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGS 77
G F Q+P D V+ G+ A LPC L Y G+VQWTK GLALG + L W RY + G+
Sbjct: 21 GPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGN 80
Query: 78 ADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGT 137
A GQ++L I EL D+ASYECQAT+A LRSR A+L VL+PPE ++ GGP + L AG
Sbjct: 81 AANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
Query: 138 PHNLTCRAF-NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P NLTCR+ +A+P ++WFRDG +GA LLK+G + S L + P D G
Sbjct: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
F CR+ ++A+P+G++T+I L + +PP VTLS P TVQEGE+V+F CQATA P + GYR
Sbjct: 201 TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYR 260
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP 316
WAKGG + A R E D SF TEPVSCEV N VGS N ST ++V F P + P+P
Sbjct: 261 WAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
Query: 317 TTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVP 376
+ D+G D + +C W GNP +TWT++ VL + L L SV DAG Y CRA
Sbjct: 321 VSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAG 380
Query: 377 RIGV--AEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE 434
G+ E L VN PP++++ A +++C + ++P PD + W+W E FLE
Sbjct: 381 LSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE 440
Query: 435 VGTLERYTVE-------RTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
G+ R+ VE R G G++S L I+ E+DF +NC+A N G G A L
Sbjct: 441 AGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
Query: 488 EEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREP 547
R++LP I A+ L+ + +R K S + L +++ + +
Sbjct: 501 GRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNL-MRIPG-SSDG 558
Query: 548 LTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYN 607
+ E++T S ++ +S ++ + E KDPTNGYY
Sbjct: 559 SSSRGPEEEETGSREDRGPIVHTDHSDL-------------VLEEKGTLETKDPTNGYYK 605
Query: 608 VR--AHEDRPSSRAVLYADYRAPG 629
VR + P SR + +++PG
Sbjct: 606 VRGVSPPASPDSRVTSF-QWKSPG 628
>gi|145275174 kin of IRRE-like 2 isoform c [Homo sapiens]
Length = 708
Score = 435 bits (1118), Expect = e-122
Identities = 239/602 (39%), Positives = 332/602 (55%), Gaps = 25/602 (4%)
Query: 18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGS 77
G F Q+P D V+ G+ A LPC L Y G+VQWTK GLALG + L W RY + G+
Sbjct: 21 GPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGN 80
Query: 78 ADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGT 137
A GQ++L I EL D+ASYECQAT+A LRSR A+L VL+PPE ++ GGP + L AG
Sbjct: 81 AANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGV 140
Query: 138 PHNLTCRAF-NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P NLTCR+ +A+P ++WFRDG +GA LLK+G + S L + P D G
Sbjct: 141 PANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGA 200
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
F CR+ ++A+P+G++T+I L + +PP VTLS P TVQEGE+V+F CQATA P + GYR
Sbjct: 201 TFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYR 260
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP 316
WAKGG + A R E D SF TEPVSCEV N VGS N ST ++V F P + P+P
Sbjct: 261 WAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEP 320
Query: 317 TTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVP 376
+ D+G D + +C W GNP +TWT++ VL + L L SV DAG Y CRA
Sbjct: 321 VSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAG 380
Query: 377 RIGV--AEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLE 434
G+ E L VN PP++++ A +++C + ++P PD + W+W E FLE
Sbjct: 381 LSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLE 440
Query: 435 VGTLERYTVE-------RTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
G+ R+ VE R G G++S L I+ E+DF +NC+A N G G A L
Sbjct: 441 AGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASL 500
Query: 488 EEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTLRKLDIKVETVNREP 547
R++LP I A+ L+ + +R K S + L +++ + +
Sbjct: 501 GRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNL-MRIPG-SSDG 558
Query: 548 LTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYN 607
+ E++T S ++ +S ++ + E KDPTNGYY
Sbjct: 559 SSSRGPEEEETGSREDRGPIVHTDHSDL-------------VLEEKGTLETKDPTNGYYK 605
Query: 608 VR 609
VR
Sbjct: 606 VR 607
>gi|145275172 kin of IRRE-like 2 isoform b [Homo sapiens]
Length = 583
Score = 392 bits (1007), Expect = e-109
Identities = 220/578 (38%), Positives = 314/578 (54%), Gaps = 28/578 (4%)
Query: 64 QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDT 123
+G W RY + G+A GQ++L I EL D+ASYECQAT+A LRSR A+L VL+PPE
Sbjct: 17 RGRAGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAP 76
Query: 124 RIDGGPVILLQAGTPHNLTCRAF-NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV 182
++ GGP + L AG P NLTCR+ +A+P ++WFRDG +GA LLK+G +
Sbjct: 77 QVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVE 136
Query: 183 SQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVF 242
S L + P D G F CR+ ++A+P+G++T+I L + +PP VTLS P TVQEGE+V+F
Sbjct: 137 STLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIF 196
Query: 243 TCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLV 302
CQATA P + GYRWAKGG + A R E D SF TEPVSCEV N VGS N ST +
Sbjct: 197 LCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTAL 256
Query: 303 NVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVT 362
+V F P + P+P + D+G D + +C W GNP +TWT++ VL + L L SV
Sbjct: 257 DVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVG 316
Query: 363 QADAGTYTCRAIVPRIGV--AEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPP 420
DAG Y CRA G+ E L VN PP++++ A +++C + ++P
Sbjct: 317 PEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPA 376
Query: 421 PDRIAWAWKENFLEVGTLERYTVE-------RTNSGSGVLSTLTINNVMEADFQTHYNCT 473
PD + W+W E FLE G+ R+ VE R G G++S L I+ E+DF +NC+
Sbjct: 377 PDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCS 436
Query: 474 AWNSFGPGTAIIQLEEREVLPVGIIAGATIGASILLIFFFIALVFFLYRRRKGSRKDVTL 533
A N G G A L R++LP I A+ L+ + +R K S
Sbjct: 437 ARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQ 496
Query: 534 RKLDIKVETVNREPLTMHSDREDDTASVSTATRVMKAIYSSFKDDVDLKQDLRCDTIDTR 593
+ L +++ + + + E++T S ++ +S ++ +
Sbjct: 497 KNL-MRIPG-SSDGSSSRGPEEEETGSREDRGPIVHTDHSDL-------------VLEEK 541
Query: 594 EEYEMKDPTNGYYNVR--AHEDRPSSRAVLYADYRAPG 629
E KDPTNGYY VR + P SR + +++PG
Sbjct: 542 GTLETKDPTNGYYKVRGVSPPASPDSRVTSF-QWKSPG 578
>gi|4758822 nephrin precursor [Homo sapiens]
Length = 1241
Score = 114 bits (286), Expect = 3e-25
Identities = 89/334 (26%), Positives = 142/334 (42%), Gaps = 21/334 (6%)
Query: 27 PADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLE 86
P + TVV G L C + VQW KDGL LG + +PRYR+ G G+++L
Sbjct: 38 PENLTVVEGASVELRCGVSTPGSAVQWAKDGLLLGPDPRIPGFPRYRLEGDPARGEFHLH 97
Query: 87 ITDAELSDDASYECQATEA----ALRSRRAKLTVLIPPEDTRI--DGGPVILLQAGTPHN 140
I +LSDDA YECQ + L S R L++L+PP+ + + G ++ AG +
Sbjct: 98 IEACDLSDDAEYECQVGRSEMGPELVSPRVILSILVPPKLLLLTPEAGTMVTWVAGQEYV 157
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
+ C + +AKPA I G A+ K T + + P D ++ C
Sbjct: 158 VNCVSGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARVTPRSSDNRQLLVC 217
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTL----SIEPQTVQEGERVVFTCQATANPEILGYR 256
+ + A+ + + S ++V PP + ++ V+ G+ + C A + +
Sbjct: 218 EASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHVRAGQSLELPCVARGGNPLATLQ 277
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPV---------SCEVHNKV--GSTNVSTLVNVH 305
W K G + A + + V S V SCE HN V G+ + V
Sbjct: 278 WLKNGQPVSTAWGTEHTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVT 337
Query: 306 FAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTL 339
F P ++ + +VTL+CV + P L
Sbjct: 338 FPPSAIIILGSASQTENKNVTLSCVSKSSRPRVL 371
Score = 92.0 bits (227), Expect = 2e-18
Identities = 115/499 (23%), Positives = 187/499 (37%), Gaps = 51/499 (10%)
Query: 27 PADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAG--- 81
P Q + AG R L C+ + N + W KD + + L R +GS +
Sbjct: 450 PEGQKLRAGTRVRLVCLAIGGNPEPSLMWYKDSRTVTESR-LPQESRRVHLGSVEKSGST 508
Query: 82 -QYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHN 140
L + + A + C+A + S +L V PP + I L+ G N
Sbjct: 509 FSRELVLVTGPSDNQAKFTCKAGQL---SASTQLAVQFPPTNVTILAN-ASALRPGDALN 564
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
LTC + ++ P + W ++G + EG VA+ K +L+ + D G+ TC
Sbjct: 565 LTCVSVSSNPPVNLSWDKEGERLEG-VAAPPRRAPFKGSAAARSVLLQVSSRDHGQRVTC 623
Query: 201 RSMNEAIPSGKETSIELDV-HHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAK 259
R+ + + + L+V + P + + T E + +ANP + W
Sbjct: 624 RAHSAELRETVSSFYRLNVLYRPEFLGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTF 683
Query: 260 GGFLIEDAHESRYE------------TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFA 307
G+ + A R+ T D + + C+ N G+ ++VH+A
Sbjct: 684 RGYRLSPAGGPRHRILSSGALHLWNVTRADDGLYQ--LHCQ--NSEGTAEARLRLDVHYA 739
Query: 308 PRIVVDPKPTTTDIGSDVTLTCVWVGNP--PLTLTWTK---KDSNMVLSN--------SN 354
P I PT ++G V + C NP P W + + + L + +
Sbjct: 740 PTIRALQDPTEVNVGGSVDIVCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTG 799
Query: 355 QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS--SEAVQYAVRGDG---G 409
+L + A AG Y C A R + L V P + + + A GD
Sbjct: 800 RLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHPTPLTKVAAAGDSTSSA 859
Query: 410 KVECFIGSTPPPDRIAWAWKENFLEVGTLE-RYTVERTNSGSGVLSTLTINNVMEADFQT 468
+ C P I + W +N + + + RYT + G S LTI NV A
Sbjct: 860 TLHCRARGVP---NIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYA 916
Query: 469 HYNCTAWNSFGPGTAIIQL 487
+ CTA N+ G IQL
Sbjct: 917 LFTCTATNALGSDQTNIQL 935
Score = 60.1 bits (144), Expect = 7e-09
Identities = 105/450 (23%), Positives = 173/450 (38%), Gaps = 72/450 (16%)
Query: 31 TVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSAD---AGQYNLEI 87
T VAGQ V+ CV SG + D L GQ + GS + +
Sbjct: 149 TWVAGQEYVVNCV----SGDAKPAPDITILLSGQTISDISANVNEGSQQKLFTVEATARV 204
Query: 88 TDAELSDDASYECQATEAALRSR-RAKLTV--LIPP-----EDTRIDGGPVILLQAGTPH 139
T + C+A+ AL + +A TV L PP E +D G V +AG
Sbjct: 205 TPRSSDNRQLLVCEASSPALEAPIKASFTVNVLFPPGPPVIEWPGLDEGHV---RAGQSL 261
Query: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT 199
L C A P AT+ W ++G ST + + S L++ D G +
Sbjct: 262 ELPCVARGGNPLATLQWLKNGQP-----VSTAWGTEHTQAVARSVLVMTVRPEDHGAQLS 316
Query: 200 CRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAK 259
C + N +E I L V PP+ + + + E + V +C + ++ + RW
Sbjct: 317 CEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQTENKNVTLSCVSKSSRPRVLLRWWL 376
Query: 260 GGFLI----EDAHESRYETNVDYSFFT---------EPVSCEVHNKVGSTNV---STLVN 303
G + E + + ++ S T ++CE ++ + S ++N
Sbjct: 377 GWRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEAFTKETFKKSLILN 436
Query: 304 VHF-APRIVVDPKPTTTDI--GSDVTLTCVWV-GNPPLTLTWTKKDSNMVLSN------- 352
V + A ++ ++ P + G+ V L C+ + GNP +L W KDS V +
Sbjct: 437 VKYPAQKLWIEGPPEGQKLRAGTRVRLVCLAIGGNPEPSLMW-YKDSRTVTESRLPQESR 495
Query: 353 --------------SNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPI-ISS 397
S +L+L + + +TC+A G L V PP ++
Sbjct: 496 RVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA-----GQLSASTQLAVQFPPTNVTI 550
Query: 398 EAVQYAVR-GDGGKVECFIGSTPPPDRIAW 426
A A+R GD + C S+ PP ++W
Sbjct: 551 LANASALRPGDALNLTCVSVSSNPPVNLSW 580
Score = 55.1 bits (131), Expect = 2e-07
Identities = 103/404 (25%), Positives = 147/404 (36%), Gaps = 61/404 (15%)
Query: 16 SQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI---------VQWTKDGLALGMGQGL 66
S TQ P + T++A A+ P LN + + + W K+G L +G+
Sbjct: 534 SASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERL---EGV 590
Query: 67 KAWPRYRVV-GSADAGQYNLEITDAELSDDASYECQATEAALR---SRRAKLTVLIPPED 122
A PR GSA A L+++ + + C+A A LR S +L VL PE
Sbjct: 591 AAPPRRAPFKGSAAARSVLLQVSSRDHGQRVT--CRAHSAELRETVSSFYRLNVLYRPEF 648
Query: 123 TRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV 182
V ++ G + N P A FR +L G
Sbjct: 649 LGEQVLVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALH--- 705
Query: 183 SQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVF 242
L N T D G ++ N E + LDVH+ PT+ +P V G V
Sbjct: 706 ---LWNVTRADDG-LYQLHCQNSE--GTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDI 759
Query: 243 TCQATANPEILG-YRWAKGGFLIEDAHESRYE---------TNVDYSFFTE--PVSCEVH 290
C ANP + G + W + G ED E + ++ + C V
Sbjct: 760 VCTVDANPILPGMFNWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVD 819
Query: 291 NKVGSTNVSTL-VNVHFAPRIVVDPKPTTT-----DIGSDVTLTCVWVGNPPLTLTWTKK 344
N V L + V FAP+ V P P T D S TL C G P + TWTK
Sbjct: 820 NGVAPPARRLLRLVVRFAPQ-VEHPTPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKN 878
Query: 345 DSNMVLS--------------NSNQLLLKSVTQA-DAGTYTCRA 373
+ L +S+ L + +V+ A D +TC A
Sbjct: 879 GVPLDLQDPRYTEHTYHQGGVHSSLLTIANVSAAQDYALFTCTA 922
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 107 bits (266), Expect = 5e-23
Identities = 129/509 (25%), Positives = 197/509 (38%), Gaps = 72/509 (14%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R ++P D V G+ A LPC ++W K+G + ++ PR +
Sbjct: 65 RIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVAT---VREDPRAHRLLLPSG 121
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ I + D+ Y C A A SR A L V + +D R G V++ G
Sbjct: 122 ALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGNVVVA-VG 180
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGT---QQEGAVASTELLKDGKRETTVSQLLINPTDLD 193
P L C P ++ W +DG ++EG + ++ GK L+++ T
Sbjct: 181 EPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRIT----IRGGK-------LMMSHTLKS 229
Query: 194 IGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEIL 253
++ C + N A + + E+ V P+ Q V V F C+ +P
Sbjct: 230 DAGMYVCVASNMA-GERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPR 288
Query: 254 GYRWAKGGFLIEDAH--ESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVN 303
RW K ED RYE D+S + VS C N VG S ++
Sbjct: 289 -LRWRK-----EDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLS 342
Query: 304 VHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL------------- 350
VH P++V P+ G V C GNPP + W K+ S ++L
Sbjct: 343 VHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFS 402
Query: 351 -SNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNG-------PPIISSEAVQY 402
S QL + +V + DAG Y C+A+ + + + L + G P I+ A Q
Sbjct: 403 VSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKAL-LEIKGASLDGLPPVILQGPANQT 461
Query: 403 AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVM 462
V G + C + P P + W +L+ L+ T+ TL I NV
Sbjct: 462 LVLGSSVWLPCRVTGNPQPS-VRWKKDGQWLQGDDLQFKTMAN--------GTLYIANVQ 512
Query: 463 EADFQTHYNCTAWNSFGPGTAIIQLEERE 491
E D Y+C A +S G T L+ RE
Sbjct: 513 EMD-MGFYSCVAKSSTGEATWSGWLKMRE 540
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 106 bits (265), Expect = 7e-23
Identities = 130/491 (26%), Positives = 188/491 (38%), Gaps = 60/491 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ L C + ++W KDG + K PR +
Sbjct: 48 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD---KDDPRSHRMLLPSG 104
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ SY C A SR A L V + +D R + V++ AG
Sbjct: 105 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA-AG 163
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P L C+ P TI W +D + + K+ + +L+I+ T
Sbjct: 164 EPAILECQPPRGHPEPTIYWKKDKVRIDD--------KEERISIRGGKLMISNTRKSDAG 215
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
++TC N + EL V PT Q V E E V F CQ +P+ R
Sbjct: 216 MYTCVGTN-MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VR 273
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFAP 308
W K D RY+ DY+ + C N+VG S + V P
Sbjct: 274 WKKDD---ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 330
Query: 309 RIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------SNSN 354
+ VV P+ G VT C GNP + W K+ S +L S +
Sbjct: 331 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 390
Query: 355 QLLLKSVTQADAGTYTCRAIVPR---IGVAEREVP--LYVNGPPIISSEAVQYAVRGDG- 408
L + ++ ++DAG Y C+A+ + A+ EV L PPII + DG
Sbjct: 391 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 450
Query: 409 GKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQT 468
++C P P I+W KE F G R T++ TL I N+ +D T
Sbjct: 451 ALLKCKATGDPLP-VISWL-KEGFTFPGRDPRATIQEQ-------GTLQIKNLRISDTGT 501
Query: 469 HYNCTAWNSFG 479
Y C A +S G
Sbjct: 502 -YTCVATSSSG 511
Score = 38.9 bits (89), Expect = 0.018
Identities = 45/159 (28%), Positives = 59/159 (37%), Gaps = 18/159 (11%)
Query: 12 SDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAWP 70
S T + +F P DQ V G+ PC N V W K+G + P
Sbjct: 321 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 380
Query: 71 RYRVVGSADAGQYNLEITDAELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGP 129
R S +L IT+ + SD Y CQA T A +A+L V D D P
Sbjct: 381 NSRCSVSPTG---DLTITNIQRSDAGYYICQALTVAGSILAKAQLEV----TDVLTDRPP 433
Query: 130 VILLQAGTPHNLT--------CRAFNAKPAATIIWFRDG 160
I+LQ L C+A P I W ++G
Sbjct: 434 PIILQGPANQTLAVDGTALLKCKA-TGDPLPVISWLKEG 471
Score = 37.0 bits (84), Expect = 0.068
Identities = 28/100 (28%), Positives = 37/100 (37%), Gaps = 16/100 (16%)
Query: 290 HNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------ 343
H G S L F PRIV P G TL C G P T+ W K
Sbjct: 29 HQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE 88
Query: 344 ------KDSNMVLSNSNQLLLKSV----TQADAGTYTCRA 373
+ M+L + + L+ V ++ D G+Y C A
Sbjct: 89 TDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVA 128
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 106 bits (265), Expect = 7e-23
Identities = 130/491 (26%), Positives = 188/491 (38%), Gaps = 60/491 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ L C + ++W KDG + K PR +
Sbjct: 32 RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETD---KDDPRSHRMLLPSG 88
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ SY C A SR A L V + +D R + V++ AG
Sbjct: 89 SLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVA-AG 147
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P L C+ P TI W +D + + K+ + +L+I+ T
Sbjct: 148 EPAILECQPPRGHPEPTIYWKKDKVRIDD--------KEERISIRGGKLMISNTRKSDAG 199
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
++TC N + EL V PT Q V E E V F CQ +P+ R
Sbjct: 200 MYTCVGTN-MVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPT-VR 257
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFAP 308
W K D RY+ DY+ + C N+VG S + V P
Sbjct: 258 WKKDD---ADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPP 314
Query: 309 RIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------SNSN 354
+ VV P+ G VT C GNP + W K+ S +L S +
Sbjct: 315 QFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTG 374
Query: 355 QLLLKSVTQADAGTYTCRAIVPR---IGVAEREVP--LYVNGPPIISSEAVQYAVRGDG- 408
L + ++ ++DAG Y C+A+ + A+ EV L PPII + DG
Sbjct: 375 DLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT 434
Query: 409 GKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQT 468
++C P P I+W KE F G R T++ TL I N+ +D T
Sbjct: 435 ALLKCKATGDPLP-VISWL-KEGFTFPGRDPRATIQEQ-------GTLQIKNLRISDTGT 485
Query: 469 HYNCTAWNSFG 479
Y C A +S G
Sbjct: 486 -YTCVATSSSG 495
Score = 38.9 bits (89), Expect = 0.018
Identities = 45/159 (28%), Positives = 59/159 (37%), Gaps = 18/159 (11%)
Query: 12 SDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAWP 70
S T + +F P DQ V G+ PC N V W K+G + P
Sbjct: 305 SATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQP 364
Query: 71 RYRVVGSADAGQYNLEITDAELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGP 129
R S +L IT+ + SD Y CQA T A +A+L V D D P
Sbjct: 365 NSRCSVSPTG---DLTITNIQRSDAGYYICQALTVAGSILAKAQLEV----TDVLTDRPP 417
Query: 130 VILLQAGTPHNLT--------CRAFNAKPAATIIWFRDG 160
I+LQ L C+A P I W ++G
Sbjct: 418 PIILQGPANQTLAVDGTALLKCKA-TGDPLPVISWLKEG 455
Score = 35.4 bits (80), Expect = 0.20
Identities = 26/91 (28%), Positives = 35/91 (38%), Gaps = 16/91 (17%)
Query: 299 STLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------------KDS 346
S L F PRIV P G TL C G P T+ W K +
Sbjct: 22 SRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSH 81
Query: 347 NMVLSNSNQLLLKSV----TQADAGTYTCRA 373
M+L + + L+ V ++ D G+Y C A
Sbjct: 82 RMLLPSGSLFFLRIVHGRRSKPDEGSYVCVA 112
>gi|21686977 cell adhesion molecule 4 [Homo sapiens]
Length = 388
Score = 104 bits (260), Expect = 3e-22
Identities = 93/328 (28%), Positives = 138/328 (42%), Gaps = 41/328 (12%)
Query: 4 LLVWILTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGM 62
LL+W Q QT + TV G A + C L Y G IV
Sbjct: 12 LLLWAAAAGPGAGQEVQTE------NVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLF 65
Query: 63 GQGLKAWPRYRV-VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPE 121
G +A R + + + ++DA L D+ Y CQ + A LTVL+ PE
Sbjct: 66 FNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPE 125
Query: 122 -------DTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLK 174
+ ++GG V L+C ++PAAT+ W+RD + +G +S E
Sbjct: 126 NPVVEVREQAVEGGEV---------ELSCLVPRSRPAATLRWYRDRKELKGVSSSQE--- 173
Query: 175 DGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSG--KETSIELDVHHPPTVTLSIEPQ 232
+GK + S + D G + C + N+A+PSG K+T LDV + PT +
Sbjct: 174 NGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQA 233
Query: 233 TVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYET-------NVDYSFFTEPV 285
V+EG+ +V TC T NP RW +G + + E+ ET + D +T
Sbjct: 234 VVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYT--- 290
Query: 286 SCEVHNKVGSTNVSTLVNVHFAPRIVVD 313
CE NK G + V V + P VV+
Sbjct: 291 -CEASNKHGHAR-ALYVLVVYDPGAVVE 316
Score = 41.2 bits (95), Expect = 0.004
Identities = 49/219 (22%), Positives = 80/219 (36%), Gaps = 31/219 (14%)
Query: 218 DVHHP-PTVTLSIEPQT--------VQEGERVVFTCQATANPEILGYRWAKGGFLIEDAH 268
D HH T+T+ + P+ EG V +C + RW + ++
Sbjct: 110 DTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVS 169
Query: 269 ESR-----------YETNVDYSFFTEPVSCEVHNKV----GSTNVSTLVNVHFAPRIVVD 313
S+ VD + CE N+ S +++V ++P +
Sbjct: 170 SSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIH 229
Query: 314 PKPTTTDIGSDVTLTCVWVGNP-PLTLTWTKKDSNM---VLSNSNQLLLKSVTQADAGTY 369
G + LTC GNP P + W + + ++ + L L + AD GTY
Sbjct: 230 ASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTY 289
Query: 370 TCRAIVPRIGVAEREVPLYVNGPPII--SSEAVQYAVRG 406
TC A + G A L V P + + +V YA+ G
Sbjct: 290 TCEA-SNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVG 327
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 102 bits (255), Expect = 1e-21
Identities = 117/497 (23%), Positives = 199/497 (40%), Gaps = 54/497 (10%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADAG 81
F ++P Q V R L ++ + + ++W KD L G W D
Sbjct: 4770 FVEKPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWK--------DDT 4821
Query: 82 QYNLEITDAELSDDASYECQ-ATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHN 140
+LE+ A+ +D +Y CQ + + + +A L V PP+ + PV++L+ G
Sbjct: 4822 STSLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIK-KPSPVLVLRNGQSTT 4880
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
C+ P + W+ DG + DG ++ I+ ++ + C
Sbjct: 4881 FECQ-ITGTPKIRVSWYLDGNEITAIQKHGISFIDG-----LATFQISGARVENSGTYVC 4934
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKG 260
+ N+A SIEL V PPT ++P V + V C+ T P W K
Sbjct: 4935 EARNDA--GTASCSIELKVKEPPTFIRELKPVEVVKYSDVELECEVTGTPPF-EVTWLKN 4991
Query: 261 GFLIEDAHESRYETNVDYSFF-----------TEPVSCEVHNKVGSTNVSTLVNVHFAPR 309
I + +Y S F T C V N+ GS + ST V + P
Sbjct: 4992 NREIRSS--KKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPS 5049
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------KDSNMVLS---NSNQLLLKS 360
+ + TTT + S T G+PP+++TW K +D N+ +S + L ++S
Sbjct: 5050 FIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRS 5109
Query: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAV-RGDGGKVECFIGSTP 419
V +G YTC+A GV L V P I +A V D +EC + TP
Sbjct: 5110 VDNGHSGRYTCQA-KNESGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTP 5168
Query: 420 PPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
+ W ++ ++ +++ N+ +++ I +VM+ D Y N FG
Sbjct: 5169 ---ELKVKWLKDGKQIVPSRYFSMSFENN----VASFRIQSVMKQD-SGQYTFKVENDFG 5220
Query: 480 PGT--AIIQLEEREVLP 494
+ A +++ ++ + P
Sbjct: 5221 SSSCDAYLRVLDQNIPP 5237
Score = 85.9 bits (211), Expect = 1e-16
Identities = 127/509 (24%), Positives = 201/509 (39%), Gaps = 89/509 (17%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKD---------GLALGMGQGLKAWPR 71
RF ++ +D + V G+ L + I V W KD + + + + A +
Sbjct: 7493 RFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENI-ATLQ 7551
Query: 72 YRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVI 131
+ V A+AG+Y +I + D EC AT + L T++ PE ++ G
Sbjct: 7552 FSRVEPANAGKYTCQIKN----DAGMQECFATLSVLEPA----TIVEKPESIKVTTGDTC 7603
Query: 132 LLQ---AGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETT----VSQ 184
L+ AGTP T WF+DG EL D K + + VS
Sbjct: 7604 TLECTVAGTPELSTK------------WFKDGK---------ELTSDNKYKISFFNKVSG 7642
Query: 185 L-LINPTDLDIGRVFTCRSMNEAIPSGKET---SIEL-DVHHPPTVTLSIEPQTVQEGER 239
L +IN D G V++ N P GK++ S+++ D PP+ T ++ G
Sbjct: 7643 LKIINVAPSDSG-VYSFEVQN---PVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSS 7698
Query: 240 VVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS-----------CE 288
VV C+ +P I W G I +Y+T + + V+ C
Sbjct: 7699 VVMECKVYGSPPI-SVSWFHEGNEISSGR--KYQTTLTDNTCALTVNMLEESDSGDYTCI 7755
Query: 289 VHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM 348
N GS S + V P V P P G++VT T + G PP +++W K S +
Sbjct: 7756 ATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSEL 7815
Query: 349 V--------LSNS-NQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEA 399
V L +S +L L V + +G YTC + G A LY+ P
Sbjct: 7816 VPGDRCNVSLEDSVAELELFDVDTSQSGEYTC-IVSNEAGKASCTTHLYIKAPAKFVKRL 7874
Query: 400 VQYAV-RGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTI 458
Y++ +G +E TPP I+ WK+N + V +R + T + + +
Sbjct: 7875 NDYSIEKGKPLILEGTFTGTPP---ISVTWKKNGINVTPSQRCNI--TTTEKSAILEIPS 7929
Query: 459 NNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
+ V +A YNC N+ G + Q+
Sbjct: 7930 STVEDAG---QYNCYIENASGKDSCSAQI 7955
Score = 84.0 bits (206), Expect = 5e-16
Identities = 100/391 (25%), Positives = 147/391 (37%), Gaps = 75/391 (19%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLLNYSGIVQ--WTKDGLALGMGQGLKAWPRYRVVGSADA 80
F+++ D G L C LN S +Q W +DG+ L + L+ S
Sbjct: 6177 FARQLKDIEQTVGLPVTLTC-RLNGSAPIQVCWYRDGVLLRDDENLQT--------SFVD 6227
Query: 81 GQYNLEITDAELSDDASYECQATEA-ALRSRRAKLTVLIPPEDTRIDGGPVIL-LQAGTP 138
L+I +LS Y C A+ S A+LT P + D PV + + AG
Sbjct: 6228 NVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAGES 6287
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQE----------GAVASTELLKDGKRETTVSQLLIN 188
+ C A+P I W +D + G +LK GK
Sbjct: 6288 ADFECHVTGAQPMR-ITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKG---------- 6336
Query: 189 PTDLDIGRVFTCRSMNEAIPSGKET-SIELDVHHPPTVTLSIEPQTV-QEGERVVFTCQA 246
D G+ +TC++ N+ GK+ S +L V PP +E V ++GE + C+
Sbjct: 6337 ----DSGQ-YTCQATNDV---GKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKI 6388
Query: 247 TANPEI----------LGYRWAKGGFLIEDA-----HESRYETNVDYSFFTEPVSCEVHN 291
+ +PEI L W I +E+ E + DY CE HN
Sbjct: 6389 SGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYI-------CEAHN 6441
Query: 292 KVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLS 351
VG + ST + V P P P GSDV L C G PP + W K + S
Sbjct: 6442 GVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNS 6501
Query: 352 NSNQLLLK---------SVTQADAGTYTCRA 373
++ K ++ +D G Y C+A
Sbjct: 6502 KKFKITSKHFDTSLHILNLEASDVGEYHCKA 6532
Score = 83.6 bits (205), Expect = 6e-16
Identities = 93/366 (25%), Positives = 148/366 (40%), Gaps = 46/366 (12%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAA-LRS 109
V W KDG + + A RYR+ + G +LEI +++D ++ C+AT + +
Sbjct: 4144 VSWFKDG------KEIAASDRYRI--AFVEGTASLEIIRVDMNDAGNFTCRATNSVGSKD 4195
Query: 110 RRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTC--RAFNAKPAATIIWFRDGTQQEGAV 167
L V PP G +L P + C F TI WF+ G ++ +
Sbjct: 4196 SSGALIVQEPPSFVTKPGSKDVL-----PGSAVCLKSTFQGSTPLTIRWFK-GNKELVSG 4249
Query: 168 ASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTL 227
S + K+ E+++ L+ +D +TC+ N A G E S L V P T
Sbjct: 4250 GSCYITKEAL-ESSLELYLVKTSD---SGTYTCKVSNVA--GGVECSANLFVKEPATFVE 4303
Query: 228 SIEP-QTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYE----------TNV 276
+EP Q +++G+ C+ T P I W I+++ + R T+V
Sbjct: 4304 KLEPSQLLKKGDATQLACKVTGTPPIK-ITWFANDREIKESSKHRMSFVESTAVLRLTDV 4362
Query: 277 DYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPP 336
E + CE N+ GS + S++V V +P + KP DV L G PP
Sbjct: 4363 GIEDSGEYM-CEAQNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPP 4421
Query: 337 LTLTWTK---------KDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPL 387
+TW K K + + L + ADAG Y CR + +G + +
Sbjct: 4422 FEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADAGEYQCR-VTNEVGSSICSARV 4480
Query: 388 YVNGPP 393
+ PP
Sbjct: 4481 TLREPP 4486
Score = 83.6 bits (205), Expect = 6e-16
Identities = 121/503 (24%), Positives = 205/503 (40%), Gaps = 62/503 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R ++P TV G L CV+ + +W KDG + L A ++ +
Sbjct: 6646 RIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDG------RELSADSKHHITFINKV 6699
Query: 81 GQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQ-----A 135
+L+I AE+SD Y + + +S TV + D + + L+
Sbjct: 6700 A--SLKIPCAEMSDKGLYSFEVKNSVGKSN---CTVSVHVSDRIVPPSFIRKLKDVNAIL 6754
Query: 136 GTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET--TVSQLLINPTDLD 193
G L CR + P + + WF+DG + + S + E T++ L+ P+D
Sbjct: 6755 GASVVLECRVSGSAPIS-VGWFQDGNE----IVSGPKCQSSFSENVCTLNLSLLEPSDTG 6809
Query: 194 IGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEIL 253
I +TC + N A E S L V PP+ + + V G + FT P
Sbjct: 6810 I---YTCVAANVA--GSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFK 6864
Query: 254 GYRWAKGGFLI---EDAHESRYETNVDYSFF-TEPV-----SCEVHNKVGSTNVSTLVNV 304
+W KG + E + S + + F +P+ SC V N GS + +T + V
Sbjct: 6865 -VKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFV 6923
Query: 305 HFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKD---------SNMVLSNSNQ 355
V + + GS + L + G PP++++W K + S + S
Sbjct: 6924 KEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTI 6983
Query: 356 LLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP--IISSEAVQYAVRGDGGKVEC 413
L + T D Y+C I G E + V PP I E V+ AV G+ ++C
Sbjct: 6984 LEILESTIEDYAQYSC-LIENEAGQDICEALVSVLEPPYFIEPLEHVE-AVIGEPATLQC 7041
Query: 414 FIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCT 473
+ TP I +W + ++ + Y ++ N+ +++L IN V +D Y+C
Sbjct: 7042 KVDGTP---EIRISWYKEHTKLRSAPAYKMQFKNN----VASLVINKVDHSDV-GEYSCK 7093
Query: 474 AWNSFG--PGTAIIQLEEREVLP 494
A NS G +A++ ++ R++ P
Sbjct: 7094 ADNSVGAVASSAVLVIKARKLPP 7116
Score = 79.3 bits (194), Expect = 1e-14
Identities = 116/503 (23%), Positives = 189/503 (37%), Gaps = 65/503 (12%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLK-------AWPRYRV 74
F +P + G+ C + + I + W KD + G K A
Sbjct: 7214 FDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLK 7273
Query: 75 VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTR-IDGGPVILL 133
VG DAGQY ++ D S A+L V PP + ++ ++
Sbjct: 7274 VGKGDAGQYTCYASNIAGKDSCS--------------AQLGVQEPPRFIKKLEPSRIVKQ 7319
Query: 134 QAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLD 193
T + C+ P ++W++D T+ + + D +V+ L ++ ++
Sbjct: 7320 DEFTRYE--CK-IGGSPEIKVLWYKDETEIQESSKFRMSFVD-----SVAVLEMHNLSVE 7371
Query: 194 IGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANP--E 251
+TC + N A + TS++ V PP P +G V C+ P
Sbjct: 7372 DSGDYTCEAHNAAGSASSSTSLK--VKEPPIFRKKPHPIETLKGADVHLECELQGTPPFH 7429
Query: 252 ILGYR-------WAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNV 304
+ Y+ K + E+ S + NVD + E C+ N VGS + +
Sbjct: 7430 VSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGE-YQCKATNDVGSDTCVGSIAL 7488
Query: 305 HFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSN---------- 354
PR V +T +G +V L G P+++ W K +V + N
Sbjct: 7489 KAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIA 7548
Query: 355 QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAV-RGDGGKVEC 413
L V A+AG YTC+ I G+ E L V P I + V GD +EC
Sbjct: 7549 TLQFSRVEPANAGKYTCQ-IKNDAGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLEC 7607
Query: 414 FIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCT 473
+ TP ++ W ++ E+ + +Y + N SG L I NV +D Y+
Sbjct: 7608 TVAGTP---ELSTKWFKDGKELTSDNKYKISFFNKVSG----LKIINVAPSDSGV-YSFE 7659
Query: 474 AWNSFGPG--TAIIQLEEREVLP 494
N G TA +Q+ +R V P
Sbjct: 7660 VQNPVGKDSCTASLQVSDRTVPP 7682
Score = 77.8 bits (190), Expect = 3e-14
Identities = 101/430 (23%), Positives = 170/430 (39%), Gaps = 40/430 (9%)
Query: 84 NLEITDAELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLT 142
+L ++ E+ D Y CQA +A ++ A L+V P T + I + G P L
Sbjct: 4542 SLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATIT--EEAVSIDVTQGDPATLQ 4599
Query: 143 CRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRS 202
+ F+ T WF+DG QE + S + TVS L I T+ +T
Sbjct: 4600 VK-FSGTKEITAKWFKDG--QELTLGSKYKISV---TDTVSILKIISTEKKDSGEYTFEV 4653
Query: 203 MNEAIPSGKETSIE-LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGG 261
N+ S + I LD+ PP+ T ++ +G + C A + +W K
Sbjct: 4654 QNDVGRSSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLEC-IVAGSHPISIQWFKDD 4712
Query: 262 FLIEDAHESRYETNVDYSFF---------TEPVSCEVHNKVGSTNVSTLVNVHFAPRIVV 312
I + + ++ + + +F + +C NK G S + V P V
Sbjct: 4713 QEISASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVE 4772
Query: 313 DPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL---------SNSNQLLLKSVTQ 363
P+ + + V L + G P+T+ W K + + S L L +
Sbjct: 4773 KPQSQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKA 4832
Query: 364 ADAGTYTCRAIVPRIGVAEREVPLYVNGPP--IISSEAVQYAVRGDGGKVECFIGSTPPP 421
D+GTY C+ + +G A + L+V PP I V G EC I TP
Sbjct: 4833 TDSGTYICQ-LSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTP-- 4889
Query: 422 DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPG 481
+I +W + E+ ++++ + + L+T I+ + T Y C A N G
Sbjct: 4890 -KIRVSWYLDGNEITAIQKHGISFIDG----LATFQISGARVENSGT-YVCEARNDAGTA 4943
Query: 482 TAIIQLEERE 491
+ I+L+ +E
Sbjct: 4944 SCSIELKVKE 4953
Score = 77.0 bits (188), Expect = 6e-14
Identities = 116/508 (22%), Positives = 186/508 (36%), Gaps = 62/508 (12%)
Query: 13 DTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPR 71
D + F++ + V G +L C + S I V W + + G +
Sbjct: 5792 DVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGA------K 5845
Query: 72 YRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR-RAKLTVLIPPEDTRIDGGPV 130
Y+ S + L++ + SD +Y C A A RA LTV PP + + P+
Sbjct: 5846 YQTTFSDNV--CTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVK-EPEPL 5902
Query: 131 ILLQAGTPHNLTCRA-FNAKPAATIIWFRDGTQQEGAVASTELLKDGKR----ETTVSQL 185
+L N+T + P + WFR + EL+K + E TV++L
Sbjct: 5903 EVLPG---KNVTFTSVIRGTPPFKVNWFR---------GARELVKGDRCNIYFEDTVAEL 5950
Query: 186 LINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQ 245
+ D+ +TC N A + T L V P + +V+ G+ ++
Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAGQASCTT--RLFVKEPAAFLKRLSDHSVEPGKSIILEST 6008
Query: 246 ATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFF---------TEPVSCEVHNKVGST 296
T I W K GF I + + T SCE+ N+ G
Sbjct: 6009 YTGTLPI-SVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Query: 297 NVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-------- 348
LV+ P V + +P +G V+L C G P +T++W K D+ +
Sbjct: 6068 VCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRT 6127
Query: 349 -VLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQY----A 403
+N L+ V D+G YTC+A IG A + + + S A Q
Sbjct: 6128 YFTNNVATLVFNKVNINDSGEYTCKA-ENSIGTASSKTVFRIQERQLPPSFARQLKDIEQ 6186
Query: 404 VRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME 463
G + C + + P I W + G L R S ++TL I +
Sbjct: 6187 TVGLPVTLTCRLNGSAP---IQVCWYRD----GVLLRDDENLQTSFVDNVATLKILQT-D 6238
Query: 464 ADFQTHYNCTAWNSFGPGTAIIQLEERE 491
Y+C+A N G ++ +L RE
Sbjct: 6239 LSHSGQYSCSASNPLGTASSSARLTARE 6266
Score = 75.9 bits (185), Expect = 1e-13
Identities = 91/356 (25%), Positives = 137/356 (38%), Gaps = 62/356 (17%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEA-ALRS 109
V W KDG+ L L+ + V L+I + S Y C A+ S
Sbjct: 7147 VSWYKDGVLLKDDANLQTSFVHNVA--------TLQILQTDQSHIGQYNCSASNPLGTAS 7198
Query: 110 RRAKLTVLIPPEDTRIDGGPVIL-LQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVA 168
AKL + D PV + L G C P I W +D
Sbjct: 7199 SSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIK-ITWAKD--------- 7248
Query: 169 STELLKDGKRETTVSQLLINPTDLDIGR----VFTCRSMNEAIPSGKET-SIELDVHHPP 223
+ E+ G + T+ + T L +G+ +TC + N A GK++ S +L V PP
Sbjct: 7249 NREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIA---GKDSCSAQLGVQEPP 7305
Query: 224 TVTLSIEP-QTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA--------------- 267
+EP + V++ E + C+ +PEI W K I+++
Sbjct: 7306 RFIKKLEPSRIVKQDEFTRYECKIGGSPEIK-VLWYKDETEIQESSKFRMSFVDSVAVLE 7364
Query: 268 -HESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVT 326
H E + DY+ CE HN GS + ST + V P P P T G+DV
Sbjct: 7365 MHNLSVEDSGDYT-------CEAHNAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVH 7417
Query: 327 LTCVWVGNPPLTLTWTKKDSNM-------VLSNS--NQLLLKSVTQADAGTYTCRA 373
L C G PP ++W K + ++S + + + +V AD G Y C+A
Sbjct: 7418 LECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKA 7473
Score = 70.5 bits (171), Expect = 6e-12
Identities = 104/466 (22%), Positives = 185/466 (39%), Gaps = 83/466 (17%)
Query: 85 LEITDAELSDDASYECQATE-AALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
+++ + D + C+A A S K+ V PP + P++ +L C
Sbjct: 5481 IQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFP--PIVETLKNAEVSLEC 5538
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSM 203
+ P ++W++D Q + S++ K + S ++N DIG + C++
Sbjct: 5539 E-LSGTPPFEVVWYKDKRQ----LRSSKKYKIASKNFHTSIHILNVDTSDIGE-YHCKAQ 5592
Query: 204 NEAIPSGKETSI-ELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF 262
NE G +T + + + PP + TV GE I +W K
Sbjct: 5593 NEV---GSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIF-VQWLK--- 5645
Query: 263 LIEDAHESRYETNVDYSFF----------TEPVS-----CEVHNKVGST-NVSTLVNVHF 306
E R N+ +F EP + C++ N G N++TL+ +
Sbjct: 5646 --EKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLE- 5702
Query: 307 APRIVVDPK-PTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNS----------NQ 355
P ++V+ P T +G TL C G P L++ W KD ++ S+ +
Sbjct: 5703 -PAVIVEKAGPMTVTVGETCTLECKVAGTPELSVEW-YKDGKLLTSSQKHKFSFYNKISS 5760
Query: 356 LLLKSVTQADAGTYT-----------CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAV 404
L + SV + DAGTYT C A+V V++R VP P V
Sbjct: 5761 LRILSVERQDAGTYTFQVQNNVGKSSCTAVV---DVSDRAVP-----PSFTRRLKNTGGV 5812
Query: 405 RGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEA 464
G +EC + + P I+ AW ++ + +Y +++ + TL +N++ +
Sbjct: 5813 LGASCILECKVAGSSP---ISVAWFHEKTKIVSGAKYQTTFSDN----VCTLQLNSLDSS 5865
Query: 465 DFQTHYNCTAWNSFGPG--TAIIQLEE-----REVLPVGIIAGATI 503
D +Y C A N G A++ ++E +E P+ ++ G +
Sbjct: 5866 D-MGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNV 5910
Score = 70.1 bits (170), Expect = 7e-12
Identities = 115/518 (22%), Positives = 192/518 (37%), Gaps = 56/518 (10%)
Query: 10 TLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQ-WTKDGLALGMGQGLKA 68
T + T ++ F P T G+ A C + I W KDG AL
Sbjct: 3540 TATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPS----- 3594
Query: 69 WPRYRVVGSADAGQYNLEITDAELSDDASYECQATEA-ALRSRRAKLTVLIPPEDTRIDG 127
P +R+ S ++ LE+++ + D Y C+A+ +A+L ++ P + +
Sbjct: 3595 -PNWRI--SDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELIIIDKPHFIK-EL 3650
Query: 128 GPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKR--ETTVSQL 185
PV H L C+ + T+ W +DG + KD K E ++ L
Sbjct: 3651 EPVQSAINKKVH-LECQVDEDRKV-TVTWSKDGQKLPPG-------KDYKICFEDKIATL 3701
Query: 186 LINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQ-EGERVVFTC 244
I L + C + NEA S + V PP+ ++P + GE C
Sbjct: 3702 EIPLAKLKDSGTYVCTASNEA--GSSSCSATVTVREPPSFVKKVDPSYLMLPGESARLHC 3759
Query: 245 QATANPEILGYRWAKGGFLIEDAHESR-YETNVDYSFFTEPV--------SCEVHNKVGS 295
+ +P ++ W K + +++ R Y N + V SCE N VGS
Sbjct: 3760 KLKGSP-VIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGS 3818
Query: 296 TNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ 355
+ ST + + P + +P G++ L C G P ++W K + S +
Sbjct: 3819 DSCSTEIVIKEPPSFIKTLEPADIVRGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYR 3878
Query: 356 LL---------LKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ-YAVR 405
L + S AD G Y C + +G + PP + A+
Sbjct: 3879 LFSQKSLVCLEIFSFNSADVGEYEC-VVANEVGKCGCMATHLLKEPPTFVKKVDDLIALG 3937
Query: 406 GDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEAD 465
G ++ + + P +E E G ++ S S ++ L I +V +
Sbjct: 3938 GQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKM-------SFSNGVAVLIIPDV-QIS 3989
Query: 466 FQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATI 503
F Y C A N G T++ +L +E P II A +
Sbjct: 3990 FGGKYTCLAENEAGSQTSVGELIVKE--PAKIIERAEL 4025
Score = 68.2 bits (165), Expect = 3e-11
Identities = 105/494 (21%), Positives = 183/494 (37%), Gaps = 62/494 (12%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADAG 81
F+++ + ++G V+ C + I V W +G + G+ +Y+ + +
Sbjct: 7684 FTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGR------KYQTTLTDNTC 7737
Query: 82 QYNLEITDAELSDDASYECQATEAALRSR-RAKLTVLIPPEDTRIDGGPVILLQAGTPHN 140
L + E SD Y C AT A A LTV PP + +L T N
Sbjct: 7738 A--LTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVL----TGTN 7791
Query: 141 LTCRAF-NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT 199
+T + P ++ WF+ ++ L+D +V++L + D +T
Sbjct: 7792 VTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLED-----SVAELELFDVDTSQSGEYT 7846
Query: 200 CRSMNEAIPSGKET-SIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
C NEA GK + + L + P + ++++G+ ++ T P I W
Sbjct: 7847 CIVSNEA---GKASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPI-SVTWK 7902
Query: 259 KGGFLIEDAHESRYETNVDYSFFTEPVS---------CEVHNKVGSTNVSTLVNVHFAPR 309
K G + + T + P S C + N G + S + + P
Sbjct: 7903 KNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPY 7962
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQLLLKS 360
V +P +G +L C G P + ++W K D+ + +N L+
Sbjct: 7963 FVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQ 8022
Query: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNG---PPIISSEA--VQYAVRGDGGKVECFI 415
V D+G Y C+A +G L V PP S + VQ V G +C I
Sbjct: 8023 VDINDSGEYICKA-ENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETV-GLPVVFDCAI 8080
Query: 416 GSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEAD--FQTHYNCT 473
+ P I+ +W ++ + + N + L N+ + D Y+CT
Sbjct: 8081 SGSEP---ISVSWYKD-------GKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCT 8130
Query: 474 AWNSFGPGTAIIQL 487
A N G ++ +L
Sbjct: 8131 ATNPIGSASSSARL 8144
Score = 67.4 bits (163), Expect = 5e-11
Identities = 95/417 (22%), Positives = 155/417 (37%), Gaps = 40/417 (9%)
Query: 85 LEITDAELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
L+I + Y CQA E+ + A L V P + ++ + + P L C
Sbjct: 5105 LQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQI--VEKAKSVDVTEKDPMTLEC 5162
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSM 203
P + W +DG Q + + S + + D G+ +T +
Sbjct: 5163 -VVAGTPELKVKWLKDGKQ----IVPSRYFSMSFENNVASFRIQSVMKQDSGQ-YTFKVE 5216
Query: 204 NEAIPSGKETSIE-LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF 262
N+ S + + LD + PP+ T + G + C+ + + I +W K G
Sbjct: 5217 NDFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISA-QWFKDGK 5275
Query: 263 LIEDAHESR---YETNVDYSFF------TEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVD 313
I + + R +E +V T +C+V N G S ++ V P +V
Sbjct: 5276 EISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVK 5335
Query: 314 PKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMV--------LSNSNQLL-LKSVTQA 364
P S V + G PP + W K D +V L S L L SV +
Sbjct: 5336 PGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDAS 5395
Query: 365 DAGTYTCRAIVPRIGVAEREVPLYVNGPP--IISSEAVQYAVRGDGGKVECFIGSTPPPD 422
G YTC + +G L V PP + EA + GD ++EC I +P
Sbjct: 5396 KTGQYTCH-VTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSP--- 5451
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
I W N E+ ++Y + +S ++ + +NN+ D + C A N G
Sbjct: 5452 EIRVVWFRNEHELPASDKYRMTFIDS----VAVIQMNNLSTED-SGDFICEAQNPAG 5503
Score = 65.9 bits (159), Expect = 1e-10
Identities = 98/454 (21%), Positives = 165/454 (36%), Gaps = 72/454 (15%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
+F + D ++ G+ +L I V W K+G+ P R +
Sbjct: 7869 KFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGI--------NVTPSQRCNITTTE 7920
Query: 81 GQYNLEITDAELSDDASYECQATEAALR-SRRAKLTVLIPPEDTRIDGGPVILLQAGTPH 139
LEI + + D Y C A+ + S A++ +L PP + + + G
Sbjct: 7921 KSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVK--QLEPVKVSVGDSA 7978
Query: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT 199
+L C+ P + W++ T+ + T K R V+ L+ N D++ +
Sbjct: 7979 SLQCQLAGT-PEIGVSWYKGDTK----LRPTTTYKMHFRNN-VATLVFNQVDINDSGEYI 8032
Query: 200 CRSMNEAIPSGKETSIELDVHH-PPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
C++ N T + + PP+ + + G VVF C A + E + W
Sbjct: 8033 CKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDC-AISGSEPISVSWY 8091
Query: 259 KGGFLIEDAHESRYETNVDYSFFTEPV---------------SCEVHNKVGSTNVST--- 300
K G ++D+ NV SF SC N +GS + S
Sbjct: 8092 KDGKPLKDS------PNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLI 8145
Query: 301 LVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLS 351
L P + P +G C G P+ ++W K + L
Sbjct: 8146 LTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLE 8205
Query: 352 NSNQLLLKSVTQADAGTYTCRAI--------VPRIGVAEREVPLYVNGPPIIS--SEAVQ 401
NS L + V + D+G YTC A+ ++ + ER +P P SE V+
Sbjct: 8206 NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIP-----PSFTKRLSETVE 8260
Query: 402 YAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEV 435
G+ K+E + + P I AW +N +E+
Sbjct: 8261 -ETEGNSFKLEGRVAGSQP---ITVAWYKNNIEI 8290
Score = 64.7 bits (156), Expect = 3e-10
Identities = 82/348 (23%), Positives = 137/348 (39%), Gaps = 65/348 (18%)
Query: 79 DAGQYNLEITDAELSDDASYECQA-TEAALRSRRAKLTVLIP----PEDTRIDGGPVILL 133
D +Y L + +A D A Y C+A + + + A L+V +P P+ P I+
Sbjct: 3290 DGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIIT 3349
Query: 134 -------QAGTPHNLTCRAFNA-------------KPAA--TIIWFRDGTQQEGAVASTE 171
G P CR KP+ + F D Q E A A E
Sbjct: 3350 PLQDTVTSEGQPARFQCRVSGTDLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE 3409
Query: 172 LLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK-----ETSIELDVHHPPTVT 226
E T + + N +G+V + +++ P E IE+++ P +
Sbjct: 3410 ------DEGTYTFVASNA----VGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIK 3459
Query: 227 LSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA-----HESRYETNVDYSFF 281
IEP V G FTC+ + P + ++W K G I ++ S+Y ++++
Sbjct: 3460 RKIEPLEVALGHLAKFTCEIQSAPNV-RFQWFKAGREIYESDKCSIRSSKYISSLEI-LR 3517
Query: 282 TEPV-----SCEVHNKVGSTNVSTLVNV--HFAPRIVVDPKPTTTDIGSDVTLTCVWVGN 334
T+ V +C+ N+ GS + + + V + P + PK TT +G C G
Sbjct: 3518 TQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGT 3577
Query: 335 PPLTLTWTKKDSNMVLS---------NSNQLLLKSVTQADAGTYTCRA 373
P + W K + + S N + L L ++T D G Y+C+A
Sbjct: 3578 PVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKA 3625
Score = 61.6 bits (148), Expect = 3e-09
Identities = 98/460 (21%), Positives = 167/460 (36%), Gaps = 62/460 (13%)
Query: 25 QEPADQTVVAGQRAVLP----CVLLNYSG----IVQWTKDGLALGMGQGLKAWPRYRVVG 76
QEP G + VLP C+ + G ++W K L G
Sbjct: 4203 QEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYI-------- 4254
Query: 77 SADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDG-GPVILLQA 135
+ +A + +LE+ + SD +Y C+ + A + + T ++ P LL+
Sbjct: 4255 TKEALESSLELYLVKTSDSGTYTCKVSNVA-GGVECSANLFVKEPATFVEKLEPSQLLKK 4313
Query: 136 GTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV--SQLLINPTDLD 193
G L C+ P I WF + E+ + K + S ++ TD+
Sbjct: 4314 GDATQLACKV-TGTPPIKITWFAN---------DREIKESSKHRMSFVESTAVLRLTDVG 4363
Query: 194 I--GRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPE 251
I + C + NEA S + V P T +P V + V+ + P
Sbjct: 4364 IEDSGEYMCEAQNEA--GSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPP 4421
Query: 252 ILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPV-----------SCEVHNKVGSTNVST 300
W K ++ +Y+T + + + C V N+VGS+ S
Sbjct: 4422 F-EITWFKDNTILRSGR--KYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSA 4478
Query: 301 LVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------KDSNMVLSNSN 354
V + P + + T++ G G+ P+T+TW K +D N+ ++ N
Sbjct: 4479 RVTLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFEN 4538
Query: 355 ---QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAV-RGDGGK 410
L L + G Y C+A G+ L V P I+ EAV V +GD
Sbjct: 4539 NVASLYLSGIEVKHDGKYVCQA-KNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPAT 4597
Query: 411 VECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS 450
++ T I W ++ E+ +Y + T++ S
Sbjct: 4598 LQVKFSGT---KEITAKWFKDGQELTLGSKYKISVTDTVS 4634
Score = 61.2 bits (147), Expect = 3e-09
Identities = 96/432 (22%), Positives = 165/432 (38%), Gaps = 48/432 (11%)
Query: 85 LEITDAELSDDASYECQATEAAL-RSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
L I +A D Y C+A S LTV PP T+ PV L+ G+ L C
Sbjct: 6422 LTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQ-KPSPVGALK-GSDVILQC 6479
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSM 203
+ P ++W +D Q V +++ K + S ++N D+G + C++
Sbjct: 6480 E-ISGTPPFEVVWVKDRKQ----VRNSKKFKITSKHFDTSLHILNLEASDVGE-YHCKAT 6533
Query: 204 NEAIPSGKET-SIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKG-G 261
NE G +T S + PP + + G+ V I W K G
Sbjct: 6534 NEV---GSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPI-SVVWLKDRG 6589
Query: 262 FLIEDAHESR--YETNVDYSFFTEPVS-------CEVHNKVGSTNVSTLVNVHFAPRIVV 312
+I ++ +R + N+ P + C++ N G S ++ V RI+
Sbjct: 6590 EVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIE 6649
Query: 313 DPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSN---------QLLLKSVTQ 363
P+P T G+ L CV G P L+ W K + + + L +
Sbjct: 6650 KPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEM 6709
Query: 364 ADAGTYTCRAIVPRIGVAEREVPLYVNG----PPIISSEAVQYAVRGDGGKVECFIGSTP 419
+D G Y+ + +G + V ++V+ P I A+ G +EC + +
Sbjct: 6710 SDKGLYSFE-VKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSA 6768
Query: 420 PPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
P + W N + G + +S S + TL + +++E Y C A N G
Sbjct: 6769 PIS-VGWFQDGNEIVSGP------KCQSSFSENVCTLNL-SLLEPSDTGIYTCVAANVAG 6820
Query: 480 PG--TAIIQLEE 489
+A++ ++E
Sbjct: 6821 SDECSAVLTVQE 6832
Score = 60.1 bits (144), Expect = 7e-09
Identities = 85/347 (24%), Positives = 132/347 (38%), Gaps = 49/347 (14%)
Query: 52 QWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRR 111
QW KDG + +YR+V +LE+ + EL D A+Y C+ + A
Sbjct: 5269 QWFKDGKEISTSA------KYRLV--CHERSVSLEVNNLELEDTANYTCKVSNVAGDDAC 5320
Query: 112 AKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAF-NAKPAATIIWFRDGTQQEGAVAST 170
+ + + P + G QA + +A P I WF+D
Sbjct: 5321 SGILTVKEPPSFLVKPGRQ---QAIPDSTVEFKAILKGTPPFKIKWFKD---------DV 5368
Query: 171 ELLKDGK----RETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVT 226
EL+ K E + S L + D +TC N+ + S T++ L V PP
Sbjct: 5369 ELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTND-VGSDSCTTMLL-VTEPPKFV 5426
Query: 227 LSIEP-QTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDY------- 278
+E + V+ G+ C+ +PEI W + + + + R T +D
Sbjct: 5427 KKLEASKIVKAGDSSRLECKIAGSPEIRVV-WFRNEHELPASDKYRM-TFIDSVAVIQMN 5484
Query: 279 SFFTEPVS---CEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNP 335
+ TE CE N GST+ ST V V P P T ++V+L C G P
Sbjct: 5485 NLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVSLECELSGTP 5544
Query: 336 PLTLTWTKKDSNMVLSNSNQLLLK---------SVTQADAGTYTCRA 373
P + W K + S ++ K +V +D G Y C+A
Sbjct: 5545 PFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKA 5591
Score = 53.5 bits (127), Expect = 7e-07
Identities = 98/442 (22%), Positives = 170/442 (38%), Gaps = 73/442 (16%)
Query: 29 DQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEIT 88
D TV AG+ A C L V+W +G K P +VV ++ + L +
Sbjct: 12204 DVTVTAGETATFDCELSYEDIPVEWYL--------KGKKLEPSDKVVPRSEGKVHTLTLR 12255
Query: 89 DAELSDDASYECQA----TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
D +L D + A T A L + + P ED ++ G +L+
Sbjct: 12256 DVKLEDAGEVQLTAKDFKTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEV------- 12308
Query: 145 AFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN 204
++ A + WF++GT+ + E++ DG+ V +L+I+ + + +TC + +
Sbjct: 12309 ---SRENAKVKWFKNGTEILKS-KKYEIVADGR----VRKLVIHDCTPEDIKTYTCDAKD 12360
Query: 205 EAIPSGKETSIELDVHHPPTVTLSIEPQT---VQEGERVVFTCQATANPEILGYRWAKGG 261
+TS L+V PP V + P T V+E E F C+ + E +W K G
Sbjct: 12361 ------FKTSCNLNV-VPPHVEF-LRPLTDLQVREKEMARFECELSR--ENAKVKWFKDG 12410
Query: 262 FLIEDAHESRYE-----------TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRI 310
I+ +Y+ N SCEV S ++ L +
Sbjct: 12411 AEIKKG--KKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLTVLEEEAVFTKN 12468
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL---------LKSV 361
+ + + + TD + L C V P + W K D ++ + ++L +++
Sbjct: 12469 LANIEVSETD---TIKLVCE-VSKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNA 12524
Query: 362 TQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPP 421
DAG Y CR R + +V ++ IS + G+ + C I P
Sbjct: 12525 HLEDAGNYNCRLPSSR---TDGKVKVHELAAEFISKPQNLEILEGEKAEFVCSISKESFP 12581
Query: 422 DRIAWAWKENFLEVGTLERYTV 443
+ W + LE G ++Y V
Sbjct: 12582 --VQWKRDDKTLESG--DKYDV 12599
Score = 53.1 bits (126), Expect = 9e-07
Identities = 95/436 (21%), Positives = 164/436 (37%), Gaps = 61/436 (13%)
Query: 85 LEITDAELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTR-IDGGPVILLQAGTPHNLT 142
L+ITD ++ D SY C+A + S ++ + PP + ++ ++ GT L
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTLEPADIV---RGTNALLQ 3851
Query: 143 CRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRS 202
C P I WF+D Q + S++ + +++ V + + D+G + C
Sbjct: 3852 CEVSGTGPFE-ISWFKDKKQ----IRSSKKYRLFSQKSLVCLEIFSFNSADVGE-YECVV 3905
Query: 203 MNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF 262
NE G + L PPT ++ G+ V A E + W KG
Sbjct: 3906 ANEVGKCGCMATHLLK--EPPTFVKKVDDLIALGGQTVTLQA-AVRGSEPISVTWMKGQE 3962
Query: 263 LIEDAHESRYETNVDYSFFTEP---------VSCEVHNKVGS-TNVSTLVNVHFAPRIVV 312
+I + + + + + P +C N+ GS T+V L+ V +I+
Sbjct: 3963 VIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELI-VKEPAKIIE 4021
Query: 313 DPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLS---------NSNQLLLKSVTQ 363
+ G TL G P L W K +V S N QL S
Sbjct: 4022 RAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAEL 4081
Query: 364 ADAGTYTCRAIVPRIG---------VAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECF 414
D+G YT I +G V +R++ + P V V G +++C
Sbjct: 4082 HDSGQYTFE-ISNEVGSSSCETTFTVLDRDIAPFFTKP----LRNVDSVVNGT-CRLDCK 4135
Query: 415 IGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTA 474
I + P + +W ++ E+ +RY + G+ L + + + + ++ C A
Sbjct: 4136 IAGSLP---MRVSWFKDGKEIAASDRYRIAFV-EGTASLEIIRV----DMNDAGNFTCRA 4187
Query: 475 WNSFG----PGTAIIQ 486
NS G G I+Q
Sbjct: 4188 TNSVGSKDSSGALIVQ 4203
Score = 50.8 bits (120), Expect = 5e-06
Identities = 90/402 (22%), Positives = 149/402 (37%), Gaps = 65/402 (16%)
Query: 33 VAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAE 91
V G+ A C + I V W KD + G +Y++ S +L + +
Sbjct: 8165 VVGESADFECHVTGTQPIKVSWAKDSREIRSGG------KYQI--SYLENSAHLTVLKVD 8216
Query: 92 LSDDASYECQAT-EAALRSRRAKLTV---LIPPEDTRIDGGPVILLQAGTPHNLTCRAFN 147
D Y C A E S A+L + LIPP T+ V + G L R
Sbjct: 8217 KGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETE-GNSFKLEGRVAG 8275
Query: 148 AKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAI 207
++P T+ W+++ + + ++ E+ K T V Q + ++ ++TC+ N+A
Sbjct: 8276 SQPI-TVAWYKNNIEIQ-PTSNCEITF--KNNTLVLQ--VRKAGMNDAGLYTCKVSNDAG 8329
Query: 208 PSGKETSIEL-DVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIED 266
+ +SI + + PP + P TV EGE V +C + E + +W K G I+
Sbjct: 8330 SALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGS-EPIRIQWLKAGREIKP 8388
Query: 267 AH-------------ESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVD 313
+ E R D + C+ N GS + V + P +
Sbjct: 8389 SDRCSFSFASGTAVLELRDVAKADSGDYV----CKASNVAGSDTTKSKVTIKDKPAVAPA 8444
Query: 314 PKPTTTD-------------IGSDVTLTCV-WVGNPPL-TLTWTKKDSNMV--------- 349
K D + T T + VG P+ + WTK +
Sbjct: 8445 TKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIH 8504
Query: 350 -LSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVN 390
+ +L ++ T+ D+G Y C A G E V L V+
Sbjct: 8505 QKGDEAKLEIRDTTKTDSGLYRCVAFNEH-GEIESNVNLQVD 8545
Score = 50.8 bits (120), Expect = 5e-06
Identities = 83/404 (20%), Positives = 140/404 (34%), Gaps = 61/404 (15%)
Query: 53 WTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALR-SRR 111
WTKDG A+ G K S D G + LEI + SD Y C +A S
Sbjct: 32885 WTKDGKAITQGGKYKL--------SEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSS 32936
Query: 112 AKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTE 171
KLT+ +DT TP + + + + E
Sbjct: 32937 CKLTIKAI-KDTEAQKVSTQKTSEITPQKKA--VVQEEISQKALRSEEIKMSEAKSQEKL 32993
Query: 172 LLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEP 231
LK+ + +S+ + + + ++E I + S E+ H +
Sbjct: 32994 ALKEEASKVLISEEVKKSAATSLEKSI----VHEEITKTSQASEEVRTH--AEIKAFSTQ 33047
Query: 232 QTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHN 291
++ EG+R+V ++ +W G + ++ E RY V S T + H
Sbjct: 33048 MSINEGQRLVLKANIAGATDV---KWVLNGVELTNSEEYRY--GVSGSDQTLTIKQASHR 33102
Query: 292 KVG-----STNVSTLVNVHF----------APRIVVDPKPTTTDIGSDVTLTCVWVGNPP 336
G S +V + AP + P+ + G +V TC G P
Sbjct: 33103 DEGILTCISKTKEGIVKCQYDLTLSKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPS 33162
Query: 337 LTLTWTKKD------SNMVLSNSN---QLLLKSVTQADAGTYTCRA-------------- 373
+ W K + SN+ +S S L +++ + +D+G YT +A
Sbjct: 33163 PEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLM 33222
Query: 374 IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGS 417
++P + REV L +G + +V+ K E S
Sbjct: 33223 VLPLVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSS 33266
Score = 49.7 bits (117), Expect = 1e-05
Identities = 67/328 (20%), Positives = 123/328 (37%), Gaps = 49/328 (14%)
Query: 148 AKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAI 207
++P T+ W +D + + T+ +K K E V +LLI T + +T +
Sbjct: 3082 SEPDITVQWMKDDQELQ----ITDRIKIQK-EKYVHRLLIPSTRMSDAGKYT------VV 3130
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGG----FL 263
G ++ +L V SI+ + VQ E+ + N + + W K G F
Sbjct: 3131 AGGNVSTAKLFVEGRDVRIRSIKKE-VQVIEKQRAVVEFEVNEDDVDAHWYKDGIEINFQ 3189
Query: 264 IEDAHESRYETNVDYSFFTEPVSCEVHNKV-----GSTNVSTLVNVHFAPRIVVDPKPTT 318
+++ H+ E + F +E + ++V+ VN P+++ + +P T
Sbjct: 3190 VQERHKYVVERRIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNAPEPPQVLQELQPVT 3249
Query: 319 TDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL---------SNSNQLLLKSVTQADAGTY 369
G V G P ++W K++ + LLL DA Y
Sbjct: 3250 VQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVY 3309
Query: 370 TCRA---------------IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECF 414
TC A VP + ++E+P+Y P II+ G + +C
Sbjct: 3310 TCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVY--PPAIITPLQDTVTSEGQPARFQCR 3367
Query: 415 IGSTPPPDRIAWAWKENFLEVGTLERYT 442
+ T +++W K+ ++ R T
Sbjct: 3368 VSGTDL--KVSWYSKDKKIKPSRFFRMT 3393
Score = 49.3 bits (116), Expect = 1e-05
Identities = 88/382 (23%), Positives = 146/382 (38%), Gaps = 56/382 (14%)
Query: 10 TLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAW 69
T ++ F + F++ DQTV G AVL C + + V+W K+G + LK+
Sbjct: 12274 THANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRENAKVKWFKNGTEI-----LKS- 12327
Query: 70 PRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGP 129
+Y +V AD L I D D +Y C A + L V +PP + P
Sbjct: 12328 KKYEIV--ADGRVRKLVIHDCTPEDIKTYTCDAKDF---KTSCNLNV-VPPHVEFL--RP 12379
Query: 130 VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQ----- 184
+ LQ ++ A + WF+DG + +K GK+ +S+
Sbjct: 12380 LTDLQVREKEMARFECELSRENAKVKWFKDGAE----------IKKGKKYDIISKGAVRI 12429
Query: 185 LLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTC 244
L+IN LD ++C + A SG T +E + T ++ V E + + C
Sbjct: 12430 LVINKCLLDDEAEYSC-EVRTARTSGMLTVLEEEA----VFTKNLANIEVSETDTIKLVC 12484
Query: 245 QAT-ANPEILGYRWAKGGFLI------EDAHESRYETNVDYSFFTEPVSCEVHNKVGSTN 297
+ + E++ W KG I E E R V + E + ++ S+
Sbjct: 12485 EVSKPGAEVI---WYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAG-NYNCRLPSSR 12540
Query: 298 VSTLVNVH-FAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-------V 349
V VH A + P+ G C + + W + D + V
Sbjct: 12541 TDGKVKVHELAAEFISKPQNLEILEGEKAEFVCS-ISKESFPVQWKRDDKTLESGDKYDV 12599
Query: 350 LSNSNQ--LLLKSVTQADAGTY 369
+++ + L++K T D GTY
Sbjct: 12600 IADGKKRVLVVKDATLQDMGTY 12621
Score = 47.4 bits (111), Expect = 5e-05
Identities = 79/372 (21%), Positives = 132/372 (35%), Gaps = 46/372 (12%)
Query: 83 YNLEITDAELSDDASYEC-QATEAALRSRRAKLTVLIPPEDTR-IDGGPVILLQAGTPHN 140
+NL IT + SD Y+C + E S ++ + PP + I+ +L + T +
Sbjct: 5010 FNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTTTVLKSSATFQS 5069
Query: 141 LTCRAFNAKPAATIIWFRDGT---QQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV 197
P +I W +D + + S +V+ L I D
Sbjct: 5070 TVA----GSPPISITWLKDDQILDEDDNVYISFV--------DSVATLQIRSVDNGHSGR 5117
Query: 198 FTCRSMNEAIPSGKETSIE-LDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+TC++ NE SG E L V P + + V E + + C PE L +
Sbjct: 5118 YTCQAKNE---SGVERCYAFLLVQEPAQIVEKAKSVDVTEKDPMTLECVVAGTPE-LKVK 5173
Query: 257 WAKGGFLIEDAH--ESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNV-- 304
W K G I + +E NV SF + V + +V N GS++ + V
Sbjct: 5174 WLKDGKQIVPSRYFSMSFENNVA-SFRIQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLD 5232
Query: 305 -HFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLS---------NSN 354
+ P +GS + + C G+ P++ W K + S S
Sbjct: 5233 QNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCHERSV 5292
Query: 355 QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECF 414
L + ++ D YTC+ A + P + Q A+ + +
Sbjct: 5293 SLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVEFKAI 5352
Query: 415 IGSTPPPDRIAW 426
+ T PP +I W
Sbjct: 5353 LKGT-PPFKIKW 5363
Score = 43.5 bits (101), Expect = 7e-04
Identities = 50/228 (21%), Positives = 80/228 (35%), Gaps = 21/228 (9%)
Query: 274 TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVG 333
T ++ F E + + + ++ T + AP I + K TT +G L+C VG
Sbjct: 30499 TEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVG 30558
Query: 334 NPPLTLTWTKKDSNMVLS---------NSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE 384
P + W + ++ S ++ L + + Q D G YTC A +G E
Sbjct: 30559 RPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIA-TNEVGEVETS 30617
Query: 385 VPLYVNGPPIISS----EAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLER 440
L + P + Y G ++ P P A W + E
Sbjct: 30618 SKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVP---AMTWFHGQKLLQNSEN 30674
Query: 441 YTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLE 488
T+E T + L + NV Y N FG AI+ +E
Sbjct: 30675 ITIENTEH----YTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVE 30718
Score = 42.7 bits (99), Expect = 0.001
Identities = 67/312 (21%), Positives = 128/312 (41%), Gaps = 42/312 (13%)
Query: 148 AKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAI 207
A P + W RDG + DG + +L+I T LD +T +
Sbjct: 2644 ANPDSKGEWLRDGKHLP-LTNNIRSESDGHKR----RLIIAATKLDDIGEYTYKVATS-- 2696
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA 267
+TS +L V + +++ TV E + VFT + T +P + G +W K G ++E
Sbjct: 2697 ----KTSAKLKVE-AVKIKKTLKNLTVTETQDAVFTVELT-HPNVKGVQWIKNGVVLES- 2749
Query: 268 HESRYETNVDYSFFTEPV-SCEVHN------KVGSTNVSTLVNVHFAPRIVVDPKPTTTD 320
+Y +V + ++ + +C + + ++G S ++V +I+ PK T
Sbjct: 2750 -NEKYAISVKGTIYSLRIKNCAIVDESVYGFRLGRLGASARLHVETV-KIIKKPKDVTAL 2807
Query: 321 IGSDVTLTCVWVGNPPLTLTWTKK-------DSNMVLSNS--NQLLLKSVTQADAGTYTC 371
+ V V V + + + W K D + ++S ++L+L++++ +DAG YT
Sbjct: 2808 ENATVAFE-VSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTA 2866
Query: 372 RAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKEN 431
+G E + L+V I + EC + P W +N
Sbjct: 2867 -----VVGQLECKAKLFVETLHITKTMKNIEVPETKTASFECEVSHFNVPS----MWLKN 2917
Query: 432 FLEVGTLERYTV 443
+E+ E++ +
Sbjct: 2918 GVEIEMSEKFKI 2929
Score = 42.7 bits (99), Expect = 0.001
Identities = 42/186 (22%), Positives = 73/186 (39%), Gaps = 23/186 (12%)
Query: 323 SDVTLTCVWVGNPPLTLTWTKKDSNMVLSNS-----------NQLLLKSVTQADAGTYTC 371
S+ TL C G+P + W ++ ++ +QL++ SVT DA Y
Sbjct: 30943 SNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQV 31002
Query: 372 RAI-----VPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAW 426
RA V E EVP ++ P + +A+RG+ ++ P P I W
Sbjct: 31003 RATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDP-VITW 31061
Query: 427 AWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQ 486
++ ++ + V R+ ++L N +E Y A N FG ++
Sbjct: 31062 QKGQDLIDNNGHYQVIVTRS------FTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVE 31115
Query: 487 LEEREV 492
L+ +V
Sbjct: 31116 LDVADV 31121
Score = 40.4 bits (93), Expect = 0.006
Identities = 31/118 (26%), Positives = 46/118 (38%), Gaps = 13/118 (11%)
Query: 21 TRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
T F + DQTV AV C L V+W ++G + G+ K D
Sbjct: 12823 TEFVEHLEDQTVTEFDDAVFSCQLSREKANVKWYRNGREIKEGKKYKF--------EKDG 12874
Query: 81 GQYNLEITDAELSDDASYECQATEAALRSR----RAKLTVLIPPED-TRIDGGPVILL 133
+ L I D L D+ Y C + R+R + ++ PP+D G V+ L
Sbjct: 12875 SIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFL 12932
Score = 37.7 bits (86), Expect = 0.040
Identities = 46/193 (23%), Positives = 83/193 (43%), Gaps = 17/193 (8%)
Query: 83 YNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLT 142
Y L I DA L D A+Y T + ++ +++ ED RI P+ ++ ++T
Sbjct: 12694 YTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVE-PLKDIETMEKKSVT 12752
Query: 143 CRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRS 202
+ T+ W ++G E+ D + V + T D G F
Sbjct: 12753 FWCKVNRLNVTLKWTKNGE---------EVPFDNRVSYRVDKYKHMLTIKDCG--FPDEG 12801
Query: 203 MNEAIPSGKETSI-ELDVHHPPTVTLS-IEPQTVQEGERVVFTCQATANPEILGYRWAKG 260
+ +G++ S+ EL + PT + +E QTV E + VF+CQ + E +W +
Sbjct: 12802 -EYIVTAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDDAVFSCQLSR--EKANVKWYRN 12858
Query: 261 GFLIEDAHESRYE 273
G I++ + ++E
Sbjct: 12859 GREIKEGKKYKFE 12871
Score = 37.4 bits (85), Expect = 0.052
Identities = 32/127 (25%), Positives = 51/127 (40%), Gaps = 12/127 (9%)
Query: 35 GQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSD 94
G A+ C++ + I W KDG ++ P++R + AD L I D +LSD
Sbjct: 11133 GSSAIFECLVSPSTAITTWMKDG------SNIRESPKHRFI--ADGKDRKLHIIDVQLSD 11184
Query: 95 DASYECQATEA-ALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAAT 153
Y C ++ AKL V P + + G P L+C +
Sbjct: 11185 AGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELNKER---D 11241
Query: 154 IIWFRDG 160
++W +DG
Sbjct: 11242 VVWRKDG 11248
Score = 37.0 bits (84), Expect = 0.068
Identities = 31/113 (27%), Positives = 48/113 (42%), Gaps = 13/113 (11%)
Query: 270 SRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLV-NVHFAPRIVVDPKPTTTDI---GSDV 325
S + V+Y F V+C + N ++ AP I +D T+ I G DV
Sbjct: 27230 SNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIAKAGEDV 27289
Query: 326 TLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQLLLKSVTQADAGTY 369
+ + G PP T+TW K + N+ +S+ L + VT+ D G Y
Sbjct: 27290 QVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKY 27342
Score = 36.6 bits (83), Expect = 0.089
Identities = 62/257 (24%), Positives = 91/257 (35%), Gaps = 51/257 (19%)
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA 267
P GK + + H TVTL G ++ T ++ RW K F
Sbjct: 21359 PPGKPVPLNITRH---TVTLKWAKPEYTGGFKI--TSYIVEKRDLPNGRWLKANF----- 21408
Query: 268 HESRYETNVDYSFFTEPVSCEVH----NKVGS-------TNVSTLVNVHFAPRIVVDPKP 316
+ E S TE + E N G+ ++ T + AP+I VD K
Sbjct: 21409 -SNILENEFTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKF 21467
Query: 317 TTTDI---GSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQLLLKSVTQA 364
T I G L G PP T+ W+K + + S L+ K T+
Sbjct: 21468 KDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRR 21527
Query: 365 DAGTYTCRAIVP--------RIGVAEREVPLYVNGPPIISSEAVQYAVRG------DGG- 409
D+G YT A P + V +R P GP ++ + V DGG
Sbjct: 21528 DSGAYTLTATNPGGFAKHIFNVKVLDRPGP--PEGPLAVTEVTSEKCVLSWFPPLDDGGA 21585
Query: 410 KVECFIGSTPPPDRIAW 426
K++ +I R+AW
Sbjct: 21586 KIDHYIVQKRETSRLAW 21602
Score = 36.2 bits (82), Expect = 0.12
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 9/76 (11%)
Query: 308 PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ---------LLL 358
P +V K T G VTL C G P T+TW ++D + S Q L++
Sbjct: 943 PTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMI 1002
Query: 359 KSVTQADAGTYTCRAI 374
+ D+G +TC A+
Sbjct: 1003 REAFAEDSGRFTCSAV 1018
Score = 35.8 bits (81), Expect = 0.15
Identities = 99/446 (22%), Positives = 159/446 (35%), Gaps = 62/446 (13%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQA-TEAALRS 109
V+WTK G + QG RV + LEI D +D Y C A E
Sbjct: 8485 VKWTK-GKWRQLNQG------GRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIE 8537
Query: 110 RRAKLTVLIPPEDTRIDGG--------PVILLQAGTPHNLTCRAF--NAKPAATIIWFR- 158
L V + +I+G P++ AG + N P + R
Sbjct: 8538 SNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYARM 8597
Query: 159 -DGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIEL 217
T G + + ELLK + E T +L I +I R E + S + L
Sbjct: 8598 YGITDFRGLLQAFELLKQSQEEET-HRLEIE----EIERSERDEKEFEELVSFIQQ--RL 8650
Query: 218 DVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVD 277
P T+ IE QTV + VF N + W KG +E + ++E ++D
Sbjct: 8651 SQTEPVTLIKDIENQTVLKDNDAVFEIDIKINYPEIKLSWYKGTEKLEPS--DKFEISID 8708
Query: 278 YSFFTEPV-SCEVHNKVGSTNVSTLVNVHFAPRIVVDP------KPTTTDIGSDVTLTCV 330
T V +C++ ++ G+ + ++ A V++P + T G T+TC
Sbjct: 8709 GDRHTLRVKNCQLKDQ-GNYRLVCGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQ 8767
Query: 331 WVGNPPLTLTWTK---------KDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVA 381
+ P + W + + V ++L + V D G YTC +
Sbjct: 8768 F-SVPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTC-----KYEDL 8821
Query: 382 EREVPLYVNGPPIISSEAVQYAVRGD--GGKVECFIGSTPPPDRIAWAWKENFLEVGTLE 439
E L + PI ++ +Q V + EC + D W + E+ +
Sbjct: 8822 ETSAELRIEAEPIQFTKRIQNIVVSEHQSATFECEVSF----DDAIVTWYKGPTELTESQ 8877
Query: 440 RYTVERTNSGSGVLSTLTINNVMEAD 465
+Y G +TI+NV D
Sbjct: 8878 KYNFR----NDGRCHYMTIHNVTPDD 8899
Score = 35.8 bits (81), Expect = 0.15
Identities = 26/95 (27%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 286 SCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDI---GSDVTLTCVWVGNPPLTLTWT 342
SCEV + + + T AP + +D T + G+ + L + G P T W+
Sbjct: 28339 SCEVTGTIKAVDRLT------APELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWS 28392
Query: 343 KKDSNMVL-------SNSNQLLLKSVTQADAGTYT 370
K DSN+ L + + L +++ + DAG YT
Sbjct: 28393 KPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYT 28427
Score = 34.7 bits (78), Expect = 0.34
Identities = 24/87 (27%), Positives = 38/87 (43%), Gaps = 16/87 (18%)
Query: 302 VNVHFAPRIVVDPK---PTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLL 358
V+ AP I +D K T G+ + L G P +TWTK D M+L ++ +
Sbjct: 13682 VDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKAD--MILKQDKRITI 13739
Query: 359 KSV-----------TQADAGTYTCRAI 374
++V ++D GTY A+
Sbjct: 13740 ENVPKKSTVTIVDSKRSDTGTYIIEAV 13766
Score = 33.9 bits (76), Expect = 0.57
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 12/95 (12%)
Query: 152 ATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGK 211
A +IW + G + +++ DGK+ L+IN + D V+T A GK
Sbjct: 11513 ANVIWSK-GPDIIKSSDKFDIIADGKKHI----LVINDSQFDDEGVYT------AEVEGK 11561
Query: 212 ETSIELDVHHPPTVTLS-IEPQTVQEGERVVFTCQ 245
+TS L V +S +E QTV+EGE F C+
Sbjct: 11562 KTSARLFVTGIRLKFMSPLEDQTVKEGETATFVCE 11596
Score = 33.9 bits (76), Expect = 0.57
Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 11/95 (11%)
Query: 9 LTLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLK 67
LTLS S F +P Q + GQ + C + S ++W K+ L + + +
Sbjct: 33124 LTLSKELSDAPA--FISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVS 33181
Query: 68 AWPRYRVVGSADAGQYNLEITDAELSDDASYECQA 102
S Y+LEI +A +SD Y +A
Sbjct: 33182 I--------SRSRNVYSLEIRNASVSDSGKYTIKA 33208
Score = 33.5 bits (75), Expect = 0.75
Identities = 58/277 (20%), Positives = 95/277 (34%), Gaps = 54/277 (19%)
Query: 222 PPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA--HESRYETNVDYS 279
PPT+ ++ TV EGE V C + P W + + IE + + +++ +
Sbjct: 942 PPTLVSGLKNVTVIEGESVTLECHISGYPSPT-VTWYREDYQIESSIDFQITFQSGIARL 1000
Query: 280 FFTEP-------VSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWV 332
E +C N+ G+ + S + V + K TT
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEF---EKETTA------------- 1044
Query: 333 GNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP 392
+T +T ++ V S + S+T+ AG E P ++ P
Sbjct: 1045 ----VTEKFTTEEKRFVESRDVVMTDTSLTEEQAGP------------GEPAAPYFITKP 1088
Query: 393 PIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGV 452
VQ V G C +G P P WK++ + + T RY V N +G
Sbjct: 1089 ------VVQKLVEGGSVVFGCQVGGNPKPHVY---WKKSGVPLTTGYRYKVS-YNKQTG- 1137
Query: 453 LSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEE 489
+ ++ AD Y N G +A L E
Sbjct: 1138 -ECKLVISMTFADDAGEYTIVVRNKHGETSASASLLE 1173
Score = 33.1 bits (74), Expect = 0.98
Identities = 26/108 (24%), Positives = 47/108 (43%), Gaps = 9/108 (8%)
Query: 99 ECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFR 158
E + TE A ++ V P T + G + + G L C + P+ T+ W+R
Sbjct: 923 EAKVTETARVPAPVEIPVTPP---TLVSGLKNVTVIEGESVTLECH-ISGYPSPTVTWYR 978
Query: 159 DGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
+ Q E ++ + G +++L+I + FTC ++NEA
Sbjct: 979 EDYQIESSIDFQITFQSG-----IARLMIREAFAEDSGRFTCSAVNEA 1021
Score = 33.1 bits (74), Expect = 0.98
Identities = 34/115 (29%), Positives = 48/115 (41%), Gaps = 17/115 (14%)
Query: 295 STNVSTLVNVHFAPRIVVDPK---PTTTDIGSDVTLTCVWV-GNPPLTLTWTKKDSNMVL 350
ST + + AP IV+DP T G + L + + G P +W+K ++
Sbjct: 20363 STETIICKDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRP 20422
Query: 351 SN---------SNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVP---LYVNGPP 393
S+ S+ L +K T+ DAG YT A P G V L V GPP
Sbjct: 20423 SDITQITSTPTSSMLTIKYATRKDAGEYTITATNP-FGTKVEHVKVTVLDVPGPP 20476
Score = 32.7 bits (73), Expect = 1.3
Identities = 25/122 (20%), Positives = 45/122 (36%), Gaps = 15/122 (12%)
Query: 264 IEDAHESRYETNVDYSFFTEPVSCEVHN------KVGSTNVSTLVNVHFAPRIVVDPKPT 317
+ + ET S + S E+ + + + + + A RI+ P+
Sbjct: 32511 VREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRKIKTTLAARILTKPRSM 32570
Query: 318 TTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL---------LKSVTQADAGT 368
T G +C G P T+TW +K + S +Q+ + SV +D G
Sbjct: 32571 TVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQASDEGN 32630
Query: 369 YT 370
Y+
Sbjct: 32631 YS 32632
Score = 32.3 bits (72), Expect = 1.7
Identities = 22/93 (23%), Positives = 42/93 (45%), Gaps = 7/93 (7%)
Query: 24 SQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKA---WPRYRVVGSA-- 78
S+ DQTV Q AV C + N +W +DG L + +++ + R++ +A
Sbjct: 2623 SKPLTDQTVAESQEAVFECEVANPDSKGEWLRDGKHLPLTNNIRSESDGHKRRLIIAATK 2682
Query: 79 --DAGQYNLEITDAELSDDASYECQATEAALRS 109
D G+Y ++ ++ S E + L++
Sbjct: 2683 LDDIGEYTYKVATSKTSAKLKVEAVKIKKTLKN 2715
Score = 32.3 bits (72), Expect = 1.7
Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 11/108 (10%)
Query: 10 TLSDTFSQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAW 69
T + F G + +F DQTV G+ A C L + V W K+ L +
Sbjct: 11563 TSARLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEKMHVVWFKNDAKLHTSR----- 11617
Query: 70 PRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVL 117
V+ S++ + LE+ + L D + + Q E S A+L VL
Sbjct: 11618 ---TVLISSEGKTHKLEMKEVTLDDISQIKAQVKEL---SSTAQLKVL 11659
Score = 32.0 bits (71), Expect = 2.2
Identities = 39/153 (25%), Positives = 55/153 (35%), Gaps = 23/153 (15%)
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
+TCRA N + GT A T ++KD K SQL L
Sbjct: 1775 ITCRATN----------KYGTDHTSA---TLIVKDEKSLVEESQLPEGRKGLQ-----RI 1816
Query: 201 RSMNEAIPSGKETSIELDVHHP--PTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
+ G T + D P + L EP V EGE F C+ T P+ W
Sbjct: 1817 EELERMAHEGALTGVTTDQKEKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQ-PKVNWY 1875
Query: 259 KGGFLIEDAHESRYETNVDYSFFTEPVSCEVHN 291
G LI + R+ D + + V C+ ++
Sbjct: 1876 LNGQLIRKS--KRFRVRYDGIHYLDIVDCKSYD 1906
Score = 31.6 bits (70), Expect = 2.9
Identities = 35/159 (22%), Positives = 59/159 (37%), Gaps = 24/159 (15%)
Query: 321 IGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLLKSVTQADAGTYTCRA 373
+G + L+ + G P +TW K+D + V ++L +++ D G Y+
Sbjct: 17232 VGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYS--- 17288
Query: 374 IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFL 433
L V P + +V+ V G S D WKE
Sbjct: 17289 -------------LTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLTWKEPLD 17335
Query: 434 EVGT-LERYTVERTNSGSGVLSTLTINNVMEADFQTHYN 471
+ G+ + Y VER + S S L+ + ++ F H N
Sbjct: 17336 DGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLN 17374
Score = 31.6 bits (70), Expect = 2.9
Identities = 21/75 (28%), Positives = 36/75 (48%), Gaps = 10/75 (13%)
Query: 308 PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLS---------NSNQLLL 358
P+I++ P+ T G + + G P T W K + +V S +S+ L++
Sbjct: 18900 PKILM-PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILII 18958
Query: 359 KSVTQADAGTYTCRA 373
K VT+ D+G Y+ A
Sbjct: 18959 KDVTRKDSGYYSLTA 18973
Score = 31.6 bits (70), Expect = 2.9
Identities = 48/233 (20%), Positives = 86/233 (36%), Gaps = 42/233 (18%)
Query: 154 IIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT--CRSMNEAIPSGK 211
I++ +D T+ + +++ D +++ ++L + + V+ CR + I
Sbjct: 31625 ILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVK----GVREVYDYYCRRTMKKIKRRT 31680
Query: 212 ETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDA-HES 270
+T L+ PP TL + +T GE V F T +PE W K G I+ ++
Sbjct: 31681 DTMRLLE--RPPEFTLPLYNKTAYVGENVRFGVTITVHPE-PHVTWYKSGQKIKPGDNDK 31737
Query: 271 RYETNVD---YSFFTEPVSCE--------VHNKVGSTNVSTLVNVHFAPRIVVDPKPTTT 319
+Y D Y V+ + NK G + + V + P PT +
Sbjct: 31738 KYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV------TLHPPPTDS 31791
Query: 320 DI---------------GSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL 357
+ G V G PP TL W K + L + +++
Sbjct: 31792 TLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEII 31844
Score = 31.6 bits (70), Expect = 2.9
Identities = 18/74 (24%), Positives = 33/74 (44%), Gaps = 11/74 (14%)
Query: 308 PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTW--------TKKDSNMVLSNSNQ---L 356
P+I P + D G +T+ C + G P +TW +++ + N++ L
Sbjct: 33329 PKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTL 33388
Query: 357 LLKSVTQADAGTYT 370
++ V + D G YT
Sbjct: 33389 IIMDVQKQDGGLYT 33402
Score = 30.8 bits (68), Expect = 4.9
Identities = 26/105 (24%), Positives = 45/105 (42%), Gaps = 7/105 (6%)
Query: 149 KPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIP 208
+P WF DG Q ++K+ + T S +++ T D G +T + N A
Sbjct: 1483 RPMPETFWFHDGQQIVNDYTHKVVIKE---DGTQSLIIVPATPSDSGE-WTVVAQNRAGR 1538
Query: 209 SGKETSIELD-VHHP--PTVTLSIEPQTVQEGERVVFTCQATANP 250
S + ++ V H P ++ ++EG R+ +AT NP
Sbjct: 1539 SSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNP 1583
Score = 30.8 bits (68), Expect = 4.9
Identities = 24/74 (32%), Positives = 30/74 (40%), Gaps = 6/74 (8%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQA-TEAALRS 109
V W K G + G K + +D G Y L I DDA Y A + S
Sbjct: 31721 VTWYKSGQKIKPGDNDKKY-----TFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDS 31775
Query: 110 RRAKLTVLIPPEDT 123
+AKLTV + P T
Sbjct: 31776 CKAKLTVTLHPPPT 31789
Score = 30.4 bits (67), Expect = 6.4
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 5/65 (7%)
Query: 428 WKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
W + E+ T E YTVE N S LTI N + D Y T N+ G T + L
Sbjct: 17544 WTTDGSEIKTDEHYTVETDNFS----SVLTIKNCLRRD-TGEYQITVSNAAGSKTVAVHL 17598
Query: 488 EEREV 492
+V
Sbjct: 17599 TVLDV 17603
Score = 30.4 bits (67), Expect = 6.4
Identities = 18/66 (27%), Positives = 30/66 (45%), Gaps = 7/66 (10%)
Query: 315 KPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLLKSVTQADAG 367
K T G+ + L G PP +TW+K+ ++ + + L++ V + DAG
Sbjct: 29454 KTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAG 29513
Query: 368 TYTCRA 373
YT A
Sbjct: 29514 KYTIEA 29519
Score = 30.0 bits (66), Expect = 8.3
Identities = 25/113 (22%), Positives = 46/113 (40%), Gaps = 21/113 (18%)
Query: 274 TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDP---------KPTTTDIGSD 324
T +Y F + V NKVG+++ S + A +P K G+
Sbjct: 26149 TGAEYVFRVKSV-----NKVGASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGAS 26203
Query: 325 VTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLLKSVTQADAGTYT 370
T+T + G P + W+K D+++ + L +++ + D+G YT
Sbjct: 26204 FTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYT 26256
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 100 bits (249), Expect = 5e-21
Identities = 108/442 (24%), Positives = 181/442 (40%), Gaps = 42/442 (9%)
Query: 64 QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDT 123
QG K RVV + + L I +A + D Y CQAT+A +++ A + + I + T
Sbjct: 57 QGEKIISTQRVVVQKEGVRSRLTIYNANIEDAGIYRCQATDAKGQTQEATVVLEIYQKLT 116
Query: 124 RIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVS 183
+ + G + CR ++ PA + W ++ ++ +
Sbjct: 117 FREVVSPQEFKQGEDAEVVCRV-SSSPAPAVSWLYH-NEEVTTISDNRFAMLANNNLQI- 173
Query: 184 QLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEP--QTVQEGERVV 241
L IN +D I + C EA I + V+ PP +++ + T + GE +
Sbjct: 174 -LNINKSDEGI---YRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMT 229
Query: 242 FTCQATANPEILGYRWAKGGFLIEDAHE-----SRYETNVDYSFFTE--PVSCEVHNKVG 294
F+C+A+ +PE W + G LIE+ + S E V ++ P C NK G
Sbjct: 230 FSCRASGSPE-PAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAG 288
Query: 295 STNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLS--- 351
+ V P I+ TT + G VTL C G P +TW + +
Sbjct: 289 EDEKQAFLQVFVQPHIIQLKNETTYENG-QVTLVCDAEGEPIPEITWKRAVDGFTFTEGD 347
Query: 352 -------------NSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVN-GPPIISS 397
S+ L +K V +D+G Y C A RIG ++ + L + P IS+
Sbjct: 348 KSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEA-ASRIGGHQKSMYLDIEYAPKFISN 406
Query: 398 EAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT 457
+ + Y+ G+ + C + S PP + W+ + L + ++ ++G ++ L
Sbjct: 407 QTIYYSWEGNPINISCDVKSNPP---ASIHWRRDKLVLPAKNTTNLKTYSTGRKMI--LE 461
Query: 458 INNVMEADFQTHYNCTAWNSFG 479
I + DF YNCTA N G
Sbjct: 462 IAPTSDNDF-GRYNCTATNHIG 482
Score = 64.7 bits (156), Expect = 3e-10
Identities = 69/281 (24%), Positives = 117/281 (41%), Gaps = 41/281 (14%)
Query: 225 VTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLI--------EDAHESR---YE 273
VT+S+ + GE FTC A PE + + +G +I ++ SR Y
Sbjct: 23 VTISLSKVELSVGESKFFTCTAIGEPESIDWYNPQGEKIISTQRVVVQKEGVRSRLTIYN 82
Query: 274 TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAP---RIVVDPKPTTTDIGSDVTLTCV 330
N++ + C+ + G T +T+V + R VV P+ G D + C
Sbjct: 83 ANIEDAGI---YRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFKQ--GEDAEVVCR 137
Query: 331 WVGNPPLTLTW--------TKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAE 382
+P ++W T D+ + +N L + ++ ++D G Y C V G +
Sbjct: 138 VSSSPAPAVSWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEID 197
Query: 383 -REVPLYVNGPPIISSEAVQY---AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTL 438
R++ + VN PP IS + A RG+ C +P P A +W N +
Sbjct: 198 FRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRASGSPEP---AISWFRNGKLIEEN 254
Query: 439 ERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
E+Y ++ +N + LT+ N++ +D Y C A N G
Sbjct: 255 EKYILKGSN------TELTVRNIINSD-GGPYVCRATNKAG 288
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 99.0 bits (245), Expect = 1e-20
Identities = 119/478 (24%), Positives = 184/478 (38%), Gaps = 50/478 (10%)
Query: 27 PADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNL 85
P ++ + VL C+ + + W KDG L RY ++ + L
Sbjct: 3719 PQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA-----RYSILENGF-----L 3768
Query: 86 EITDAELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
I A ++D Y C AT AA RR L V +PP +++ T L C
Sbjct: 3769 HIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQT--TLACE 3826
Query: 145 AFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN 204
A P +I W ++ G + + + ++ R + L+I +D + C N
Sbjct: 3827 ATGI-PKPSINW-----RKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTN 3880
Query: 205 EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF-L 263
A + +++L V PP++ V + V TC A+ P W K G L
Sbjct: 3881 GA--GDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVP-FPSIHWTKNGIRL 3937
Query: 264 IEDAHESRYETNVDYSFFTEPVS------CEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
+ R ++ ++ C N GS + ++VH P I P
Sbjct: 3938 LPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSEL 3997
Query: 318 TTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS-------VTQADAGTYT 370
+ + + L C G P +TW K+ N+ S N +L S + DAGTY
Sbjct: 3998 HVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYM 4057
Query: 371 CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGG-KVECFIGSTPPPDRIAWAWK 429
C A P G A ++ L V PP+IS +Y + D + C PPPD I W K
Sbjct: 4058 CVAQNP-AGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPD-ITW-HK 4114
Query: 430 ENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
+ V ++ + + +SGS L I V D HY C A N G + +L
Sbjct: 4115 DGRAIVESIRQRVL---SSGS-----LQIAFVQPGD-AGHYTCMAANVAGSSSTSTKL 4163
Score = 91.7 bits (226), Expect = 2e-18
Identities = 137/510 (26%), Positives = 201/510 (39%), Gaps = 85/510 (16%)
Query: 18 GTQTRFSQE-PADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVV 75
G Q SQ+ P + +V+AG+ LPC + + I+ W K+ + PR+ +
Sbjct: 1076 GDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFS-----PRHTFL 1130
Query: 76 GSADAGQYNLEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVIL-L 133
S +++IT+ SD Y C AT A +A KL V +PP +I GP L +
Sbjct: 1131 PSG-----SMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPP---KIQRGPKHLKV 1182
Query: 134 QAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET-----TVSQLLIN 188
Q G ++ C A P I W + G+ +L DG+ T+S
Sbjct: 1183 QVGQRVDIPCNA-QGTPLPVITWSKGGST---------MLVDGEHHVSNPDGTLSIDQAT 1232
Query: 189 PTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQ---TVQE---GERVVF 242
P+D I +TC + N I ET I L V PPTV +EP T QE +R+ F
Sbjct: 1233 PSDAGI---YTCVATN--IAGTDETEITLHVQEPPTVE-DLEPPYNTTFQERVANQRIEF 1286
Query: 243 TCQATANPEILGYRWAKGG----------FLIEDAHESRYETNVDYSFFTEPVSCEVHNK 292
C A P+ +W G ++ED + Y C N+
Sbjct: 1287 PCPAKGTPKPT-IKWLHNGRELTGREPGISILEDGTLLVIASVTPYD--NGEYICVAVNE 1343
Query: 293 VGSTNVSTLVNVHFAPRIVVDPKPTTTDIG----SDVTLTCVWVGNPPLTLTW------- 341
G+T + VH P V+ K T++ L C G P + W
Sbjct: 1344 AGTTERKYNLKVHVPP--VIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQV 1401
Query: 342 TKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS---- 397
T+ + ++N L L T DAG Y+C+AI G +++ + V PP I
Sbjct: 1402 TESSTIQTVNNGKILKLFRATPEDAGRYSCKAI-NIAGTSQKYFNIDVLVPPTIIGTNFP 1460
Query: 398 EAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT 457
V + D +EC + TP PD I W L +G VE + G L
Sbjct: 1461 NEVSVVLNRDVA-LECQVKGTPFPD-IHWFKDGKPLFLGD---PNVELLDRG----QVLH 1511
Query: 458 INNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
+ N D + Y CT N+ G I+L
Sbjct: 1512 LKNARRND-KGRYQCTVSNAAGKQAKDIKL 1540
Score = 89.0 bits (219), Expect = 2e-17
Identities = 117/448 (26%), Positives = 172/448 (38%), Gaps = 60/448 (13%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAA-LRS 109
+ W KDG A+ R RV+ S +L+I + D Y C A A S
Sbjct: 4110 ITWHKDGRAIVESI------RQRVLSSG-----SLQIAFVQPGDAGHYTCMAANVAGSSS 4158
Query: 110 RRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVAS 169
KLTV +PP +G + + L C A + P I W +D V
Sbjct: 4159 TSTKLTVHVPPRIRSTEGHYTV--NENSQAILPCVA-DGIPTPAINWKKDN------VLL 4209
Query: 170 TELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKET-SIELDVHHPPTVTLS 228
LL E +L++ L+ +TC + N A G++T ++ L VH PT T
Sbjct: 4210 ANLLGKYTAEP-YGELILENVVLEDSGFYTCVANNAA---GEDTHTVSLTVHVLPTFTEL 4265
Query: 229 IEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS-- 286
++ +GE++ +C+AT P + W +I +S N E VS
Sbjct: 4266 PGDVSLNKGEQLRLSCKATGIP-LPKLTWTFNNNIIPAHFDS---VNGHSELVIERVSKE 4321
Query: 287 ------CEVHNKVGSTNVSTLVNVHFAPRIVVD-PKPTTTDIGSDVTLTCVWVGNPPLTL 339
C N VG V V P D P +G + L C G+P T+
Sbjct: 4322 DSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTI 4381
Query: 340 TWTKKDSNMVLSN------SNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP 393
W +K ++ +S+ + L + DAG YTC A GV ER + L + PP
Sbjct: 4382 QWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVA-TNEAGVVERSMSLTLQSPP 4440
Query: 394 IISSEAVQYAVRGDGGKV--ECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSG 451
II+ E V+ + GGK+ C P P W + +R V NS
Sbjct: 4441 IITLEPVETVINA-GGKIILNCQATGEPQP---TITWSRQGHSISWDDRVNVLSNNS--- 4493
Query: 452 VLSTLTINNVMEADFQTHYNCTAWNSFG 479
L I + + D + + C A N G
Sbjct: 4494 ----LYIADAQKED-TSEFECVARNLMG 4516
Score = 88.2 bits (217), Expect = 3e-17
Identities = 123/478 (25%), Positives = 193/478 (40%), Gaps = 64/478 (13%)
Query: 24 SQEPADQTVVAGQRAVLPCVLLNYSGI----VQWTKDGLALGMGQGLKAWPRYRVVGSAD 79
+ EP D V AV+ C SG+ + WTK+G+ L L YR++ S
Sbjct: 3900 ADEPTDFLVTKHAPAVITCTA---SGVPFPSIHWTKNGIRL-----LPRGDGYRILSSGA 3951
Query: 80 AGQYNLEITDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPVILLQAGTP 138
+EI +L+ Y C A AA + R L V PP ++L P
Sbjct: 3952 -----IEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILN--NP 4004
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
L C A P+ I W ++G + + +L G L I+ + +
Sbjct: 4005 ILLPCEA-TGTPSPFITWQKEGINVNTSGRNHAVLPSGG-------LQISRAVREDAGTY 4056
Query: 199 TCRSMNEAIPSGKETS-IELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
C + N P+G I+L+V PP ++ ++ + + + +C+A P W
Sbjct: 4057 MCVAQN---PAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPP-DITW 4112
Query: 258 AKGGFLIEDAHESRYETNVDYSF-FTEP-----VSCEVHNKVGSTNVSTLVNVHFAPRIV 311
K G I ++ R ++ F +P +C N GS++ ST + VH PRI
Sbjct: 4113 HKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIR 4172
Query: 312 VDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSN---------SNQLLLKSVT 362
T + S L CV G P + W KKD N++L+N +L+L++V
Sbjct: 4173 STEGHYTVNENSQAILPCVADGIPTPAINW-KKD-NVLLANLLGKYTAEPYGELILENVV 4230
Query: 363 QADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAV-RGDGGKVECFIGSTPPP 421
D+G YTC A G V L V+ P + ++ +G+ ++ C P P
Sbjct: 4231 LEDSGFYTCVA-NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289
Query: 422 DRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
++ W + N + +S +G S L I V + D T Y CTA NS G
Sbjct: 4290 -KLTWTFNNNIIPA---------HFDSVNG-HSELVIERVSKEDSGT-YVCTAENSVG 4335
Score = 87.4 bits (215), Expect = 4e-17
Identities = 108/430 (25%), Positives = 164/430 (38%), Gaps = 55/430 (12%)
Query: 27 PADQTVVAGQRAVLPCVLLNYSGIVQ--WTKDGLALGMGQGLKAWPRYRVVGSADAGQYN 84
P+ V+ GQ+ LPC LL + I + W K+ L + R GS
Sbjct: 896 PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITV----RSDGS------- 944
Query: 85 LEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
L I +L D Y C A+ A + + +V++ T G ++ G P L C+
Sbjct: 945 LHIERVQLQDGGEYTCVASNVAGTNNKTT-SVVVHVLPTIQHGQQILSTIEGIPVTLPCK 1003
Query: 145 AFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN 204
A + P ++IW + G + A DG S +++P + G + C + N
Sbjct: 1004 A-SGNPKPSVIWSKKGELISTSSAKFSAGADG------SLYVVSPGGEESGE-YVCTATN 1055
Query: 205 EAIPSGKETSIELDVHHPPTVT-----LSIEPQ---TVQEGERVVFTCQATANPEILGYR 256
A + ++L V+ P V LS + +V GE V C+ + P +
Sbjct: 1056 TA--GYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPI-IT 1112
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS-------CEVHNKVGSTNVSTLVNVHFAPR 309
WAK LI TE + C N G+ + +NVH P+
Sbjct: 1113 WAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPK 1172
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-------LLLKSVT 362
I PK +G V + C G P +TW+K S M++ + L + T
Sbjct: 1173 IQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQAT 1232
Query: 363 QADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS------SEAVQYAVRGDGGKVECFIG 416
+DAG YTC A G E E+ L+V PP + + Q V + C
Sbjct: 1233 PSDAGIYTCVA-TNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAK 1291
Query: 417 STPPPDRIAW 426
TP P I W
Sbjct: 1292 GTPKP-TIKW 1300
Score = 87.4 bits (215), Expect = 4e-17
Identities = 101/390 (25%), Positives = 158/390 (40%), Gaps = 41/390 (10%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110
+ W KDG + G K R L I A++S+ Y C A A +
Sbjct: 1766 IMWLKDGQLIDERDGFKILLNGR----------KLVIAQAQVSNTGLYRCMAANTAGDHK 1815
Query: 111 RA-KLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVAS 169
+ ++TV +PP + G ++ P L C A N P +I W +D A +
Sbjct: 1816 KEFEVTVHVPPT-IKSSGLSERVVVKYKPVALQCIA-NGIPNPSITWLKDDQPVNTAQGN 1873
Query: 170 TELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLS- 228
++ G R +++ L+ D GR +TC + N A + I+L VH PP++ +
Sbjct: 1874 LKIQSSG-RVLQIAKTLLE----DAGR-YTCVATNAA--GETQQHIQLHVHEPPSLEDAG 1925
Query: 229 -IEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYET-----NVDYSFFT 282
+ +TV V C+A NP + W K L+ + + +++ + +
Sbjct: 1926 KMLNETVLVSNPVQLECKAAGNP-VPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQIS 1984
Query: 283 EP--VSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLT 340
+ C N G+T + + VH AP I + + V L C G P +LT
Sbjct: 1985 DAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLT 2044
Query: 341 WTKKDSNM--------VLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP 392
W K S + VLS L L S +D G YTC A V G +R++ L V P
Sbjct: 2045 WLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVA-VNAAGEKQRDIDLRVYVP 2103
Query: 393 PIISSEAVQYAVR-GDGGKVECFIGSTPPP 421
P I E +V ++ C + PPP
Sbjct: 2104 PNIMGEEQNVSVLISQAVELLCQSDAIPPP 2133
Score = 86.7 bits (213), Expect = 7e-17
Identities = 106/449 (23%), Positives = 168/449 (37%), Gaps = 55/449 (12%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110
+ + ++G+ LG+ Q LK ++ NL+I LSD+ YEC A +A R
Sbjct: 461 LSFVRNGVTLGVDQYLK-----------ESASVNLDIAKVTLSDEGFYECIAVSSAGTGR 509
Query: 111 -RAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVAS 169
+ V PP ++ + + G LTC +A + W R+
Sbjct: 510 AQTFFDVSEPPPVIQVPNN--VTVTPGERAVLTCLIISAVD-YNLTWQRNDRDVR----- 561
Query: 170 TELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSI 229
L + R T++ L + + M + S+ L V PP VT+
Sbjct: 562 ---LAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMP 618
Query: 230 EPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS--- 286
+ Q+ G V C AT P+ W I +H RY D + F + +
Sbjct: 619 KNQSFTGGSEVSIMCSATGYPK-PKIAWTVNDMFIVGSH--RYRMTSDGTLFIKNAAPKD 675
Query: 287 -----CEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTW 341
C N G+ ++ + AP+++V +G + C G PP + W
Sbjct: 676 AGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKW 735
Query: 342 TKKDSNMVLSN-------SNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPI 394
K D + S L ++ DAG YTC AI G A ++ L V PP+
Sbjct: 736 FKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAI-NEAGRATGKITLDVGSPPV 794
Query: 395 ISSEAVQYAVR-GDGGKVECFIGSTPPPDRIAWAWKEN---FLEVGTLERYTVERTNSGS 450
E ++ G + C++ P P I W +N F ++ + RT +
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYVQGYPEP-TIKWRRLDNMPIFSRPFSVSSISQLRTGA-- 851
Query: 451 GVLSTLTINNVMEADFQTHYNCTAWNSFG 479
L I N+ +D T Y C A N FG
Sbjct: 852 -----LFILNLWASDKGT-YICEAENQFG 874
Score = 86.3 bits (212), Expect = 1e-16
Identities = 114/481 (23%), Positives = 176/481 (36%), Gaps = 59/481 (12%)
Query: 31 TVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
TV+ G + C+ + W +DG LG+ L V L++
Sbjct: 3446 TVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMV----------LQLLK 3495
Query: 90 AELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNA 148
AE D Y C A+ EA S+ L VL PP + I + P LTC A +
Sbjct: 3496 AETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIA-SG 3554
Query: 149 KPAATIIWFRDG-----TQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSM 203
PA + W +DG T Q + E+L+ + D GR +TC +
Sbjct: 3555 IPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVE-----------DTGR-YTCLAS 3602
Query: 204 NEAIPSGKETSIELDVHHPPTVTLSIEPQ--TVQEGERVVFTCQATANPEILGYRWAKGG 261
+ A KE + VH PP + + EP+ TV +V C++ A P + W + G
Sbjct: 3603 SPAGDDDKEYLVR--VHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV-ITWLRNG 3659
Query: 262 FLIEDAHESRYETNVDYSFF-------TEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDP 314
++ R + Y T +C N G T ++ V+ P I P
Sbjct: 3660 ERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGP 3719
Query: 315 KPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSN--------SNQLLLKSVTQADA 366
+ + L C+ G P +TW +KD ++ N + L ++S D
Sbjct: 3720 QSLVILLNKSTVLECIAEGVPTPRITW-RKDGAVLAGNHARYSILENGFLHIQSAHVTDT 3778
Query: 367 GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKVECFIGSTPPPDRIAW 426
G Y C A G R + L V+ PP I+ V + + P I W
Sbjct: 3779 GRYLCMA-TNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINW 3837
Query: 427 AWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQ 486
+ L V + + +SGS V+ + ++ D Y CT N G +
Sbjct: 3838 RKNGHLLNVDQ-NQNSYRLLSSGSLVIISPSV------DDTATYECTVTNGAGDDKRTVD 3890
Query: 487 L 487
L
Sbjct: 3891 L 3891
Score = 85.9 bits (211), Expect = 1e-16
Identities = 108/414 (26%), Positives = 168/414 (40%), Gaps = 67/414 (16%)
Query: 48 SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAAL 107
S + W KDG Q LK+ + A + L+I +A++SD Y C A+ A
Sbjct: 2703 SASLSWYKDG------QPLKSDDHVNIA----ANGHTLQIKEAQISDTGRYTCVASNIAG 2752
Query: 108 RSR-RAKLTVLIPPE-----------DTRIDGGPVILLQAGTPHNLTCRAFNAKPAATII 155
+ + +PP DT +G ++ P +L C NA P T+
Sbjct: 2753 EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVI-INNPISLYCET-NAAPPPTLT 2810
Query: 156 WFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSI 215
W++DG + L+ G R + + + D GR +TC ++NEA E S+
Sbjct: 2811 WYKDGHPLTS--SDKVLILPGGRVLQIPRAKVE----DAGR-YTCVAVNEA----GEDSL 2859
Query: 216 ELDVH--HPPTVTLS----IEPQTVQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAH 268
+ DV PP + + E TV + + C ++ +P W K G L+ED H
Sbjct: 2860 QYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRN-SWQKDGQPLLEDDH 2918
Query: 269 ESRYETNVDYSFFTEPVS------CEVHNKVGSTNVSTLVNVHFAPRIVVDPKP--TTTD 320
++ C N GS +NVH P V+ PK T
Sbjct: 2919 HKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPS-VIGPKSENLTVV 2977
Query: 321 IGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKS--------VTQADAGTYTCR 372
+ + ++LTC G PP L+W K + + L N+N L++ +D G YTC
Sbjct: 2978 VNNFISLTCEVSGFPPPDLSWLKNEQPIKL-NTNTLIVPGGRTLQIIRAKVSDGGEYTCI 3036
Query: 373 AIVPRIGVAEREVPLYVNGPPII-----SSEAVQYAVRGDGGKVECFIGSTPPP 421
AI + G ++++ L V PP I S +V G +EC + PPP
Sbjct: 3037 AI-NQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPP 3089
Score = 85.1 bits (209), Expect = 2e-16
Identities = 120/495 (24%), Positives = 197/495 (39%), Gaps = 67/495 (13%)
Query: 24 SQEPADQTVVAGQRAVLPCVLLNYSGIVQ-WTKDGLALGMGQGLKAWPRYRVVGSADAGQ 82
S P + TV+ + A++ C+ W KDG L K R+
Sbjct: 2876 SDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRI-------- 2927
Query: 83 YNLEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPV---ILLQAGTP 138
L+I + +++D Y C A A +++ L V +PP GP + +
Sbjct: 2928 --LQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI----GPKSENLTVVVNNF 2981
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
+LTC + P + W ++ +Q + + L+ G R + + ++ G +
Sbjct: 2982 ISLTCEV-SGFPPPDLSWLKN--EQPIKLNTNTLIVPGGRTLQIIRAKVSD-----GGEY 3033
Query: 199 TCRSMNEAIPSGKETSIELDVHHPPTV----TLSIEPQTVQEGERVVFTCQATANPEILG 254
TC ++N+A S K+ S L V+ PP++ + S+ V+EG V C++ A P +
Sbjct: 3034 TCIAINQAGESKKKFS--LTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPV- 3090
Query: 255 YRWAKGGFLIEDAHESRYETNVDYSFF---------TEPVSCEVHNKVGSTNVSTLVNVH 305
W K G +I ++ + E D T C N G + + +NV+
Sbjct: 3091 ITWYKNGRMITES--THVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVY 3148
Query: 306 FAPRIVVDPKPTTTD-IGSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQ 355
P I + + I + VTLTC G PP T+ W K + +LS ++
Sbjct: 3149 VPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSK 3208
Query: 356 LLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR---GDGGKVE 412
L + +D+G YTC A G A++ L + PP ++ + V G+ ++
Sbjct: 3209 LQIARSQHSDSGNYTCIASNME-GKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELV 3267
Query: 413 CFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNC 472
C P P I W + G ER V S +G STL I + +D Y C
Sbjct: 3268 CNANGIPTP-LIQWLKDGKPIASGETERIRV----SANG--STLNIYGALTSD-TGKYTC 3319
Query: 473 TAWNSFGPGTAIIQL 487
A N G I L
Sbjct: 3320 VATNPAGEEDRIFNL 3334
Score = 80.5 bits (197), Expect = 5e-15
Identities = 109/406 (26%), Positives = 168/406 (41%), Gaps = 54/406 (13%)
Query: 19 TQTRFSQEPADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGS 77
T T P + V G+ L C + V W KDG L +G++
Sbjct: 2291 TITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEI--------- 2341
Query: 78 ADAGQYNLEITDAELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPV-ILLQA 135
D G L++ + +SD Y C A A + ++ L+V PP P I +
Sbjct: 2342 LDEGHI-LQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVE 2400
Query: 136 GTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIG 195
+LTC A + P +I WF+DG + S +L G+ L + T ++
Sbjct: 2401 KNSVSLTCEA-SGIPLPSITWFKDGWPVSLS-NSVRILSGGR------MLRLMQTTMEDA 2452
Query: 196 RVFTCRSMNEAIPSGKETSI-ELDVHHPPTVT--LSIEPQTVQEGERVVFTCQATANPEI 252
+TC N A G+E I L V PP + ++E V+E + V TC+ T NP +
Sbjct: 2453 GQYTCVVRNAA---GEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNP-V 2508
Query: 253 LGYRWAKGGFLIED--AHE----SRYE--TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNV 304
W K G +++ AH R+ TNV T +C + G + S +NV
Sbjct: 2509 PEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPH-TGRYTCLASSPAGHKSRSFSLNV 2567
Query: 305 HFAPRIVV-----DPKPTTTDIGSDVTLTCVWVGNPPLTLTW----TKKDSN---MVLSN 352
+P I +P+ T + S +L C PP T+TW T +SN +L
Sbjct: 2568 FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPG 2627
Query: 353 SNQLLLKSVTQADAGTYTCRAIVPRIG--VAEREVPLYVNGPPIIS 396
L + + + +AG Y+C A G + EV +Y+ PPII+
Sbjct: 2628 GRTLQILNAQEDNAGRYSCVA-TNEAGEMIKHYEVKVYI--PPIIN 2670
Score = 79.7 bits (195), Expect = 9e-15
Identities = 113/496 (22%), Positives = 189/496 (38%), Gaps = 69/496 (13%)
Query: 27 PADQTVVAGQRAVLPCVLLNYS-GIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNL 85
P + +VV + L C + + W KDG L +G P ++ D GQ L
Sbjct: 1460 PNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGD-----PNVELL---DRGQV-L 1510
Query: 86 EITDAELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPV---ILLQAGTPHNL 141
+ +A +D Y+C + AA +++ KLT+ IPP I GG V I + + L
Sbjct: 1511 HLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPS---IKGGNVTTDISVLINSLIKL 1567
Query: 142 TCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCR 201
C P I W++DG + ++S++ L K + L I + +TC
Sbjct: 1568 ECET-RGLPMPAITWYKDG---QPIMSSSQALYIDKGQ----YLHIPRAQVSDSATYTCH 1619
Query: 202 SMNEAIPSGKETSIELDVHHPPTVTLSIEP---QTVQEGERVVFTCQATANPEILGYRWA 258
N A E S +DV+ PP + ++ + V + C+A NP + W
Sbjct: 1620 VANVA--GTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI-LTWL 1676
Query: 259 KGGFLIE-------DAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIV 311
K G ++ +A + E C + G + V+V P I
Sbjct: 1677 KDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIE 1736
Query: 312 VDPKPT--TTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVLSNSNQLLLKSVT 362
+ + + + + L C G+PP T+ W K +D +L N +L++
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQ 1796
Query: 363 QADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAV--QYAVRGDGGKVECFIGSTPP 420
++ G Y C A G ++E + V+ PP I S + + V+ ++C P
Sbjct: 1797 VSNTGLYRCMA-ANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPN 1855
Query: 421 PDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVME-----ADFQTHYNCTAW 475
P I W + + N+ G L + V++ + Y C A
Sbjct: 1856 PS-ITWLKDD-------------QPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVAT 1901
Query: 476 NSFGPGTAIIQLEERE 491
N+ G IQL E
Sbjct: 1902 NAAGETQQHIQLHVHE 1917
Score = 77.4 bits (189), Expect = 5e-14
Identities = 78/319 (24%), Positives = 123/319 (38%), Gaps = 34/319 (10%)
Query: 191 DLDIGRV-------FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFT 243
+LDI +V + C +++ A +T DV PP V TV GER V T
Sbjct: 483 NLDIAKVTLSDEGFYECIAVSSAGTGRAQTFF--DVSEPPPVIQVPNNVTVTPGERAVLT 540
Query: 244 CQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGS 295
C + + W + + A +R T + S + V C V ++ GS
Sbjct: 541 CLIISAVDY-NLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGS 599
Query: 296 TNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMV------ 349
+ S + V P++ V PK + GS+V++ C G P + WT D +V
Sbjct: 600 SAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR 659
Query: 350 LSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGG 409
+++ L +K+ DAG Y C A + Y+ P ++ ++ GD
Sbjct: 660 MTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDIT 719
Query: 410 KVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTH 469
+EC PPP W + LE+ ++ +L L I + D
Sbjct: 720 VMECKTSGIPPPQ---VKWFKGDLELRPSTFLIID------PLLGLLKIQETQDLD-AGD 769
Query: 470 YNCTAWNSFGPGTAIIQLE 488
Y C A N G T I L+
Sbjct: 770 YTCVAINEAGRATGKITLD 788
Score = 77.4 bits (189), Expect = 5e-14
Identities = 108/424 (25%), Positives = 161/424 (37%), Gaps = 54/424 (12%)
Query: 85 LEITDAELSDDASYECQATEAALRS-RRAKLTVLIPPEDTRIDGGP--VILLQAGTPHNL 141
L I AE+SD Y C+A A R + L V +PP I+G VI+ P L
Sbjct: 3115 LHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS---IEGPEREVIVETISNPVTL 3171
Query: 142 TCRAFNAKPAATIIWFRDGTQQEGAVA-STELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
TC A P TI W ++ + E + + +L G S+L I + +TC
Sbjct: 3172 TCDATGIPPP-TIAWLKNHKRIENSDSLEVRILSGG------SKLQIARSQHSDSGNYTC 3224
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQE--GERVVFTCQATANPEILGYRWA 258
+ N + K + + V PP+V + P V GE V C A P L +W
Sbjct: 3225 IASNMEGKAQKYYFLSIQV--PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPL-IQWL 3281
Query: 259 KGGFLIEDAHESRYETNVDYSFF---------TEPVSCEVHNKVGSTNVSTLVNVHFAPR 309
K G I R + + S T +C N G + +NV+ P
Sbjct: 3282 KDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT 3341
Query: 310 I---VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL-------LK 359
I + + T + + + + C G PP + W K + LS+ +LL +
Sbjct: 3342 IRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIV 3401
Query: 360 SVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP----IISSEAVQYAVRGDGGKVECFI 415
+D YTC A R GV + L V PP + +E + ++G + C
Sbjct: 3402 RAQVSDVAVYTCVA-SNRAGVDNKHYNLQVFAPPNMDNSMGTEEIT-VLKGSSTSMACIT 3459
Query: 416 GSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAW 475
TP P + AW + +G TV S G++ L E + Y C A
Sbjct: 3460 DGTPAP---SMAWLRDGQPLGLDAHLTV----STHGMVLQLL---KAETEDSGKYTCIAS 3509
Query: 476 NSFG 479
N G
Sbjct: 3510 NEAG 3513
Score = 73.6 bits (179), Expect = 7e-13
Identities = 108/431 (25%), Positives = 169/431 (39%), Gaps = 50/431 (11%)
Query: 85 LEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
L+I + + D Y C A A R+ K+T+ + I + ++ G+ L C
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRAT-GKITLDVGSPPVFIQEPADVSMEIGSNVTLPCY 815
Query: 145 AFNAKPAATIIWFRDGTQ----QEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
P TI W R + +V+S L+ G + ++N D G + C
Sbjct: 816 V-QGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG------ALFILNLWASDKG-TYIC 867
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKG 260
+ N+ ET++ + P + +S V EG+++ C A I RW K
Sbjct: 868 EAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKN 927
Query: 261 GFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVV 312
++ D S E V +C N G+ N +T V VH P I
Sbjct: 928 SAML--LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQH 985
Query: 313 DPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNS-------NQLLLKSVTQAD 365
+ +T G VTL C GNP ++ W+KK + S++ L + S +
Sbjct: 986 GQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEE 1045
Query: 366 AGTYTCRAIVPRIGVAEREVPLYVNGPP--------IISSEAVQYAV-RGDGGKVECFIG 416
+G Y C A G A+R+V L V P + + V+ +V G+ + C +
Sbjct: 1046 SGEYVCTA-TNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVK 1104
Query: 417 STPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWN 476
S PPP I WA KE L R+T + S + T T ++ M Y C A N
Sbjct: 1105 SLPPP-IITWA-KETQLISPFSPRHTFLPSGS-MKITETRTSDSGM-------YLCVATN 1154
Query: 477 SFGPGTAIIQL 487
G T ++L
Sbjct: 1155 IAGNVTQAVKL 1165
Score = 73.2 bits (178), Expect = 9e-13
Identities = 120/480 (25%), Positives = 177/480 (36%), Gaps = 65/480 (13%)
Query: 28 ADQTVVAGQRAVLPCVLLNYSGI----VQWTKDGLALGMGQG-LKAWPRYRVVGSADAGQ 82
+++ VV + L C+ +GI + W KD + QG LK RV
Sbjct: 1834 SERVVVKYKPVALQCIA---NGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV-------- 1882
Query: 83 YNLEITDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPVI--LLQAGTPH 139
L+I L D Y C AT AA +++ +L V PP + D G ++ + P
Sbjct: 1883 --LQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPP--SLEDAGKMLNETVLVSNPV 1938
Query: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVF 198
L C+A P I W++D G+ + T L + Q++ I + ++
Sbjct: 1939 QLECKAAG-NPVPVITWYKDNRLLSGSTSMTFLNR--------GQIIDIESAQISDAGIY 1989
Query: 199 TCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
C ++N A E L VH P+++ S V V C+A P W
Sbjct: 1990 KCVAINSA--GATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAP-SLTWL 2046
Query: 259 KGGFLIEDAHESRYE---------TNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPR 309
K G + T+ S T +C N G + V+ P
Sbjct: 2047 KDGSPVSSFSNGLQVLSGGRILALTSAQISD-TGRYTCVAVNAAGEKQRDIDLRVYVPPN 2105
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTW-------TKKDSNMVLSNSNQLLLKSVT 362
I+ + + + I V L C PP TLTW KK + N + L ++
Sbjct: 2106 IMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQ 2165
Query: 363 QADAGTYTCRAIVPRIGVAEREVPLYVNGPPII--SSEAVQYAV-RGDGGKVECFIGSTP 419
D G YTC A G E+ + + PP I S E Q V G+ + C P
Sbjct: 2166 VQDTGRYTCEA-TNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIP 2224
Query: 420 PPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
PP+ I WK+ V T V R SG L ++ E Y+C A N G
Sbjct: 2225 PPNLI---WKKKGSPVLTDSMGRV-RILSGGRQLQI----SIAEKSDAALYSCVASNVAG 2276
Score = 70.1 bits (170), Expect = 7e-12
Identities = 97/424 (22%), Positives = 166/424 (39%), Gaps = 50/424 (11%)
Query: 25 QEPADQTVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQY 83
Q P + TV G+RAVL C++++ + W ++ + + + R R + +
Sbjct: 524 QVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPA----RIRTLANL----- 574
Query: 84 NLEITDAELSDDASYECQ-ATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLT 142
+LE+ + +D Y C ++E + LTV PP+ T + G+ ++
Sbjct: 575 SLELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFT--GGSEVSIM 632
Query: 143 CRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLI-NPTDLDIGRVFTCR 201
C A P I W T + + + R T+ L I N D G ++ C
Sbjct: 633 CSA-TGYPKPKIAW----TVNDMFIVGSHRY----RMTSDGTLFIKNAAPKDAG-IYGCL 682
Query: 202 SMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGG 261
+ N A + K+ S + P + + E V G+ V C+ + P +W KG
Sbjct: 683 ASNSA-GTDKQNSTLRYIEAPKLMVVQSE-LLVALGDITVMECKTSGIPPPQ-VKWFKGD 739
Query: 262 -------FLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDP 314
FLI D + +C N+ G ++V P + +P
Sbjct: 740 LELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQEP 799
Query: 315 KPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLS-----------NSNQLLLKSVTQ 363
+ +IGS+VTL C G P T+ W + D+ + S + L + ++
Sbjct: 800 ADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWA 859
Query: 364 ADAGTYTCRAIVPRIGVAEREVPLYVNG---PPIISSEAVQYAVRGDGGKVEC-FIGSTP 419
+D GTY C A + G + E + V G P I S +V + G + C + P
Sbjct: 860 SDKGTYICEA-ENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNP 918
Query: 420 PPDR 423
P+R
Sbjct: 919 IPER 922
Score = 64.7 bits (156), Expect = 3e-10
Identities = 80/360 (22%), Positives = 132/360 (36%), Gaps = 44/360 (12%)
Query: 31 TVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYN-LEIT 88
TV +A+LPCV + + W KD + L ++G A Y L +
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLA-----------NLLGKYTAEPYGELILE 4227
Query: 89 DAELSDDASYECQATEAALR-SRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFN 147
+ L D Y C A AA + LTV + P T + G + L G L+C+A
Sbjct: 4228 NVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGD--VSLNKGEQLRLSCKATG 4285
Query: 148 AKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAI 207
P + W T + + +G S+L+I + + C + N
Sbjct: 4286 I-PLPKLTW----TFNNNIIPAHFDSVNGH-----SELVIERVSKEDSGTYVCTAENSV- 4334
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTVQE--GERVVFTCQATANPEILGYRWAKGGFLIE 265
G +I P V P E G + C+ +P +W + G IE
Sbjct: 4335 --GFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPT-IQWNRKGVDIE 4391
Query: 266 DAHESRYETNVDYSFF------TEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTT 319
+H R N + + +C N+ G S + + P I ++P T
Sbjct: 4392 ISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVI 4451
Query: 320 DIGSDVTLTCVWVGNPPLTLTWTKK------DSNMVLSNSNQLLLKSVTQADAGTYTCRA 373
+ G + L C G P T+TW+++ D + + ++N L + + D + C A
Sbjct: 4452 NAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVA 4511
Score = 64.3 bits (155), Expect = 4e-10
Identities = 97/405 (23%), Positives = 153/405 (37%), Gaps = 51/405 (12%)
Query: 48 SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAAL 107
S I+ W KD + + ++ ++ L++ A D Y C+A A
Sbjct: 1389 SPIIMWYKDNVQVTESSTIQTVNNGKI----------LKLFRATPEDAGRYSCKAINIAG 1438
Query: 108 RSRRA-KLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGA 166
S++ + VL+PP + + + L C+ P I WF+DG
Sbjct: 1439 TSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPLFLG 1497
Query: 167 VASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPT-- 224
+ ELL G+ L N D GR + C N A K+ I+L ++ PP+
Sbjct: 1498 DPNVELLDRGQ-----VLHLKNARRNDKGR-YQCTVSNAAGKQAKD--IKLTIYIPPSIK 1549
Query: 225 ---VTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFF 281
VT I +V + C+ P + W K G I + ++ Y Y
Sbjct: 1550 GGNVTTDI---SVLINSLIKLECETRGLP-MPAITWYKDGQPIMSSSQALYIDKGQYLHI 1605
Query: 282 -------TEPVSCEVHNKVGSTNVSTLVNVHFAPRI---VVDPKPTTTDIGSDVTLTCVW 331
+ +C V N G+ S V+V+ P I + P I +TL C
Sbjct: 1606 PRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKA 1665
Query: 332 VGNPPLTLTWTK-------KDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE 384
GNP LTW K D+ + + +L + S + D G Y C A G E +
Sbjct: 1666 AGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVA-TSVAGEKEIK 1724
Query: 385 VPLYVNGPPII--SSEAVQYAVRGDG-GKVECFIGSTPPPDRIAW 426
+ V PP I E + V + +++C + +PPP I W
Sbjct: 1725 YEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPP-TIMW 1768
Score = 53.5 bits (127), Expect = 7e-07
Identities = 88/387 (22%), Positives = 135/387 (34%), Gaps = 68/387 (17%)
Query: 25 QEPADQTVVAGQRAVLPCVLLNYSGI----VQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
+ P + +VV L C SGI + W KDG + + ++ +
Sbjct: 2391 RSPENISVVEKNSVSLTC---EASGIPLPSITWFKDGWPVSLSNSVRIL----------S 2437
Query: 81 GQYNLEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTPH 139
G L + + D Y C AA R+ L+VL+PP + + ++
Sbjct: 2438 GGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSV 2497
Query: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFT 199
LTC P I W +DG + A + G R ++ + + T GR +T
Sbjct: 2498 TLTCEV-TGNPVPEITWHKDGQPLQEDEAHHII--SGGRFLQITNVQVPHT----GR-YT 2549
Query: 200 CRSMNEAIPSGKETSIELDVHHPPTVTL-----SIEPQTVQEGERVVFTCQATANPEILG 254
C + + A K S L+V PT+ + E TV C+A + P
Sbjct: 2550 CLASSPA--GHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPAT- 2606
Query: 255 YRWAKGGFLIEDAHESRY-------------ETNVDYSFFTEPVSCEVHNKVGSTNVSTL 301
W K G +E R E N SC N+ G
Sbjct: 2607 ITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGR------YSCVATNEAGEMIKHYE 2660
Query: 302 VNVHFAPRIV--------VDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDS 346
V V+ P I + PK + + +TL C P +L+W K D
Sbjct: 2661 VKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDH 2720
Query: 347 NMVLSNSNQLLLKSVTQADAGTYTCRA 373
+ +N + L +K +D G YTC A
Sbjct: 2721 VNIAANGHTLQIKEAQISDTGRYTCVA 2747
>gi|54607031 immunoglobulin superfamily, member 4D [Homo sapiens]
Length = 437
Score = 96.3 bits (238), Expect = 9e-20
Identities = 92/330 (27%), Positives = 153/330 (46%), Gaps = 26/330 (7%)
Query: 17 QGTQTRFSQEPADQ--TVVAGQRAVLPC-VLLNYSGIVQWTKDGLALGMGQGLKAWPRYR 73
+G+Q +F P Q TVV G A+L C V N + +QW+ KA R
Sbjct: 22 KGSQGQF---PLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNR 78
Query: 74 V-VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDG--GPV 130
+ + A + ++ ++D LSD+ Y C +++ +A LTVL PE +I G PV
Sbjct: 79 IELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPV 138
Query: 131 ILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET-TVSQLLINP 189
+ G LTC+ +KPAA I WF++ + + E +D R+T TVS L
Sbjct: 139 M---EGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKE--EDANRKTFTVSSTLDFR 193
Query: 190 TD-LDIGRVFTCRSMNEAIPSGKETSIE-LDVHHPPTVTLSIEPQTVQEGERVVFTCQAT 247
D D G CR +E++ + + +++ L++H+ P+V + QEG+ ++ TC++
Sbjct: 194 VDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESK 253
Query: 248 ANPEILGYRWAKGGFLIEDAHE---SRYETNVDYSFFTE--PVSCEVHNKVGSTNVSTLV 302
P W K G + D S E N+ + T+ CE N +G ++ ++
Sbjct: 254 GKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVL 313
Query: 303 NVHFAPRIV----VDPKPTTTDIGSDVTLT 328
VH P + + P TT + + V +T
Sbjct: 314 IVHDVPNTLLPTTIIPSLTTATVTTTVAIT 343
Score = 58.5 bits (140), Expect = 2e-08
Identities = 68/294 (23%), Positives = 114/294 (38%), Gaps = 32/294 (10%)
Query: 123 TRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTV 182
T ++GG IL ++ T ++ PA ++F D EL++ E ++
Sbjct: 35 TVVEGGTAILTCRVDQNDNTSLQWS-NPAQQTLYFDDKKALRDN--RIELVRASWHELSI 91
Query: 183 SQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVF 242
S ++ L +TC + + K L V P ++ P V EG+ +
Sbjct: 92 S---VSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSP--VMEGDLMQL 146
Query: 243 TCQATANPEILGYRWAKGGFLIEDAH--------------ESRYETNVDYSFFTEPVSCE 288
TC+ + + RW K I+D S + VD S V C
Sbjct: 147 TCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICR 206
Query: 289 V-HNKVGSTN--VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNP-PLTLTWTK- 343
V H + +T ++ +H+ P + + P G + LTC G P P + WTK
Sbjct: 207 VDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKD 266
Query: 344 ----KDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP 393
D + ++ + +L + + + D GTY C A IG + E L V+ P
Sbjct: 267 GGELPDPDRMVVSGRELNILFLNKTDNGTYRCEA-TNTIGQSSAEYVLIVHDVP 319
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 94.4 bits (233), Expect = 4e-19
Identities = 121/463 (26%), Positives = 189/463 (40%), Gaps = 60/463 (12%)
Query: 31 TVVAGQRAVLPC-VLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
T + LPC V + + V W KD AL +G+ + P G + L++
Sbjct: 1757 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP----------GTHTLQLGR 1806
Query: 90 AELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGP--VILLQAGTPHNLTCRAF 146
A LSD Y C+A AA R ++ +L+VL+PP + GP +L++ G L+C
Sbjct: 1807 ARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET- 1865
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
+A P T+ W++DG Q T+ L+ G+R L I + +++C+ N A
Sbjct: 1866 DALPEPTVTWYKDG-QPLVLAQRTQALRGGQR------LEIQEAQVSDKGLYSCKVSNVA 1918
Query: 207 IPSGKETSIELDVHHPPTVTLSIEPQTVQE--GERVVFTCQATANPEILGYRWAKGGFLI 264
+ + + L V PPT + + +TV + G +V TC + P W K +
Sbjct: 1919 GEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMPV 1974
Query: 265 ED-------AHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
E + R + + +C N +V V APRI
Sbjct: 1975 ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR 2034
Query: 318 TTDI--GSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQLLLKSVTQADA 366
+ G +V L C G PP + W K S + + L+LK + +DA
Sbjct: 2035 EHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2094
Query: 367 GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEA----VQYAVRGDGGKVECFIGSTPPPD 422
G YTC A P G R + V PP I A + G+ + C + +PP
Sbjct: 2095 GAYTCVAHNP-AGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP-- 2151
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEAD 465
I +W ++ L + +R + GSG TL I+ V AD
Sbjct: 2152 -IHVSWLKDGLPLPLSQRTLLH----GSG--HTLRISKVQLAD 2187
Score = 89.4 bits (220), Expect = 1e-17
Identities = 122/486 (25%), Positives = 181/486 (37%), Gaps = 51/486 (10%)
Query: 27 PADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNL 85
P V Q A+LPC +V W KD + L PR+ ++ +L
Sbjct: 2488 PPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRS-----PRFEILPEG-----SL 2537
Query: 86 EITDAELSDDASYECQATEAALRSRRAK-LTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
I D Y C A+ +A R+ + L VL PP + L A TP L C
Sbjct: 2538 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN--LTLTAHTPALLPCE 2595
Query: 145 AFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN 204
A + P ++W++DG + + L + R + LL+ F C N
Sbjct: 2596 A-SGSPKPLVVWWKDGQKLD-----FRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN 2649
Query: 205 EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
E + + ++ VH PPT+ TV VV TC +T P W+K G +
Sbjct: 2650 EVGEAHR--LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSWSKAGAQL 2706
Query: 265 EDAHESRY--------ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP 316
A S Y E +C N G + + V +P + P
Sbjct: 2707 -GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSV 2765
Query: 317 TTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL------LKSVTQADAGTYT 370
+V L C G P T+TW K+ N+ S Q+L + + DAG Y
Sbjct: 2766 VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYL 2825
Query: 371 CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYA-VRGDGGKVECFIGSTPPPDRIAWAWK 429
C A G A + L V PP+I + + G + C +P P+ I W K
Sbjct: 2826 CIA-KNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPN-ITWD-K 2882
Query: 430 ENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEE 489
+ G ++T++ + L + N+ D T Y CTA N+ G + L
Sbjct: 2883 DGQPVSGAEGKFTIQPSGE-------LLVKNLEGQDAGT-YTCTAENAVGRARRRVHLTI 2934
Query: 490 REVLPV 495
VLPV
Sbjct: 2935 L-VLPV 2939
Score = 88.2 bits (217), Expect = 3e-17
Identities = 126/504 (25%), Positives = 198/504 (39%), Gaps = 64/504 (12%)
Query: 26 EPADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYN 84
E + +VVA + L C ++ W KDG L PR V SAD
Sbjct: 885 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE--------PRPGVHLSADKAL-- 934
Query: 85 LEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
L++ A++ D Y C+A A RS + L V + P + + ++ G P +L+C
Sbjct: 935 LQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFP-LRESHTLTVREGHPTSLSC 993
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVFTCRS 202
P I W +DG G A + + + V +LL + L +TC
Sbjct: 994 EC-RGVPFPKISWRKDGQPLPGEGAGLQHV------SAVGRLLYLGQAQLAQEGTYTCEC 1046
Query: 203 MNEAIPSGKETSIELDVHHPPTVTLSIEPQT----VQEGERVVFTCQATANPEILGYRW- 257
N + ++L+VH PP + EP T VQ+G + C AT P W
Sbjct: 1047 SN--VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL-ECNATGKPPPT-VTWE 1102
Query: 258 -------AKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRI 310
A+ G +++ +S + + T SC N G ++V P +
Sbjct: 1103 RDGQPVGAELGLQLQNQGQSLHVERAQAAH-TGRYSCVAENLAGRAERKFELSVLVPPEL 1161
Query: 311 VVDPKPTTT---DIGSDVTLTCVWVGNPPLTLTW-------TKKDSNMVLSNSNQLLLKS 360
+ D P T + S +TL C +G PP + W + + +L+ L +
Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQ 1221
Query: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR---GDGGKVECFIGS 417
+ D+G Y+C A G A R + V PP I +E ++ ++ G + C +
Sbjct: 1222 TQEQDSGLYSCLA-SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTG 1280
Query: 418 TPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNS 477
P P ++ W F + L R S GVL + N+ A HY+C A N+
Sbjct: 1281 HPQP-KLTW-----FKDGRPLARGDAHHI-SPDGVLLQVLQANLSSAG---HYSCIAANA 1330
Query: 478 FGPGTAIIQLEEREVLPVGIIAGA 501
G T QL +L I+ GA
Sbjct: 1331 VGEKTKHFQLS--VLLAPTILGGA 1352
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/420 (26%), Positives = 172/420 (40%), Gaps = 48/420 (11%)
Query: 31 TVVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
TV A L C L N + W ++GL PR +V+ + GQ L+++
Sbjct: 1665 TVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS------PRLQVL---EDGQV-LQVST 1714
Query: 90 AELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNA 148
AE++D ASY C A +A + L V +PP +D V + + +L C +A
Sbjct: 1715 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI-LNSSVSLPCDV-HA 1772
Query: 149 KPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIP 208
P + W++D Q ++ L G + + ++ + + +TC ++N A
Sbjct: 1773 HPNPEVTWYKD--SQALSLGEEVFLLPGTHTLQLGRARLSDSGM-----YTCEALNAA-- 1823
Query: 209 SGKETSIELDVHHPPTVTLSIE-PQ---TVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
+ ++L V PP + PQ V+ G++ V +C+ A PE W K G +
Sbjct: 1824 GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYKDGQPL 1882
Query: 265 EDAHES-------RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
A + R E SC+V N G V T P +PK
Sbjct: 1883 VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA-VRTFTLTVQVPPTFENPKTE 1941
Query: 318 TTD--IGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLLKSVTQADAGT 368
T GS + LTC G P T+TW K + V+S +L L + A AGT
Sbjct: 1942 TVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT 2001
Query: 369 YTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ--YAVRGDGGKVECFIGSTPPPDRIAW 426
YTC A + + V + P I SS + + + G +++C PPPD +AW
Sbjct: 2002 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAW 2060
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/485 (25%), Positives = 185/485 (38%), Gaps = 62/485 (12%)
Query: 24 SQEPADQTVVAGQRAVLPCVLLNYSGI----VQWTKDGLALGM-GQGLKAWPRYRVVGSA 78
+ + D TV VL C + +GI V W+K G LG G G YRV S
Sbjct: 2669 ADDQTDFTVTMMAPVVLTC---HSTGIPAPTVSWSKAGAQLGARGSG------YRVSPSG 2719
Query: 79 DAGQYNLEITDAELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPVILLQAGT 137
LEI A Y C A +A + + LTV P + V+ A
Sbjct: 2720 A-----LEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS--VVRAVAEE 2772
Query: 138 PHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV 197
L C A + P TI W ++G V ST++L G QL I +
Sbjct: 2773 EVLLPCEA-SGIPRPTITWQKEGLNVATGV-STQVLPGG-------QLRIAHASPEDAGN 2823
Query: 198 FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
+ C + N A + +T + + V PP + + + EG C+A +PE W
Sbjct: 2824 YLCIAKNSAGSAMGKTRLVVQV--PPVIENGLPDLSTTEGSHAFLPCKARGSPEP-NITW 2880
Query: 258 AKGGFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPR 309
K G + A E ++ + + +C N VG + + P
Sbjct: 2881 DKDGQPVSGA-EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV 2939
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-----LLLKSVTQA 364
P + +G + L C G+P + WT D + S Q L +V++
Sbjct: 2940 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE 2999
Query: 365 DAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKV--ECFIGSTPPPD 422
D+GTY C A R+G + ++V P++ EA Y V GG + +C + P PD
Sbjct: 3000 DSGTYVCWA-ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 3058
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGT 482
I W K+ G+ R+ ++ +LTI+ E D Y C A N G
Sbjct: 3059 -IHWI-KDGLPLRGSHLRHQLQN--------GSLTIHRT-ERDDAGRYQCLAENEMGVAK 3107
Query: 483 AIIQL 487
++ L
Sbjct: 3108 KVVIL 3112
Score = 80.5 bits (197), Expect = 5e-15
Identities = 99/392 (25%), Positives = 144/392 (36%), Gaps = 39/392 (9%)
Query: 69 WPRYRVVGSADA-------GQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPE 121
W R +V DA G++ L++ +D Y C A AA S V I
Sbjct: 2424 WHRDGIVLQEDAHTQFPERGRF-LQLQALSTADSGDYSCTARNAA-GSTSVAFRVEIHTV 2481
Query: 122 DTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETT 181
T G P + + L C+A + PA + W +D + E+L +G
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS---- 2536
Query: 182 VSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVV 241
L I P + C + N A +L V PP + S T+ +
Sbjct: 2537 ---LRIQPVLAQDAGHYLCLASNSA--GSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPAL 2591
Query: 242 FTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFF-TEP-------VSCEVHNKV 293
C+A+ +P+ L W G L + Y + T P C V N+V
Sbjct: 2592 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 2651
Query: 294 GSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDS 346
G + V VH P I D T + + V LTC G P T++W+K + S
Sbjct: 2652 GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGS 2711
Query: 347 NMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS-EAVQYAVR 405
+S S L + AG YTC A GVA + V L V P++ +V AV
Sbjct: 2712 GYRVSPSGALEIGQALPIHAGRYTCSA-RNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 2770
Query: 406 GDGGKVECFIGSTPPPDRIAWAWKENFLEVGT 437
+ + C P P W++ L V T
Sbjct: 2771 EEEVLLPCEASGIPRP---TITWQKEGLNVAT 2799
Score = 76.6 bits (187), Expect = 8e-14
Identities = 110/451 (24%), Positives = 171/451 (37%), Gaps = 44/451 (9%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110
V W KDG LG G P R D G +L + SD +Y C A A
Sbjct: 2058 VAWLKDGSPLGQDMG----PHLRFY--LDGG--SLVLKGLRASDAGAYTCVAHNPAGEDA 2109
Query: 111 RAK-LTVLIPPEDTR-IDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVA 168
R + VL+PP + DG ++ + G + C P + W +DG
Sbjct: 2110 RLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPPIHVSWLKDGLPLP---L 2165
Query: 169 STELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLS 228
S L G T L I+ L +FTC + + A + + ++++ V P V
Sbjct: 2166 SQRTLLHGSGHT----LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV---PPVLEP 2218
Query: 229 IEPQT---VQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAHESRYETNVDY--SFFT 282
+E Q V G V C+A P L W K G L+ + E ++ + +
Sbjct: 2219 VEFQNDVVVVRGSLVELPCEARGVPLPL-VSWMKDGEPLLSQSLEQGPSLQLEAVGAGDS 2277
Query: 283 EPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDI--GSDVTLTCVWVGNPPLTLT 340
SC ++ G + V P I +PT + G+ + L C G P +T
Sbjct: 2278 GTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT 2337
Query: 341 WTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP-IISSEA 399
W K + +N + + DAG YTC A P G E+ + V PP I+
Sbjct: 2338 WHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESP-AGAIEKSFRVRVQAPPNIVGPRG 2396
Query: 400 VQYAVRGDGGK--VECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT 457
++ V G+ +EC + + P P +I W L+ ++ LST
Sbjct: 2397 PRFVVGLAPGQLVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTAD 2455
Query: 458 INNVMEADFQTHYNCTAWNSFGPGTAIIQLE 488
+ Y+CTA N+ G + ++E
Sbjct: 2456 SGD---------YSCTARNAAGSTSVAFRVE 2477
Score = 75.5 bits (184), Expect = 2e-13
Identities = 103/414 (24%), Positives = 163/414 (39%), Gaps = 66/414 (15%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110
+ W KDG L +VV + Q L++ A+ SD Y C+A+ A +
Sbjct: 343 ITWFKDGALLPTST--------KVVYTRGGRQ--LQLGRAQSSDAGVYTCKASNAVGAAE 392
Query: 111 RA-KLTVLIPPEDTRIDGGP-VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVA 168
+A +L V +PP G P V+ AG P L C A P+ T+ W +G VA
Sbjct: 393 KATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVA-RGHPSPTLSWHHEGLP----VA 447
Query: 169 STELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLS 228
+ + + ET S L + +++C + + A + + S+E+ V V
Sbjct: 448 ESN---ESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEG 504
Query: 229 IEPQTVQEGERVVFTCQATANP--------------EILGYRWAKGGFLIEDAHESRYET 274
+ T G+ + CQA+ +P E+ G + A G + H
Sbjct: 505 LGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDH-----V 559
Query: 275 NVDYSFFTEPVSCEVHNKVGSTNVSTLVNVH--FAPRIVVDP---------KPTTTDIGS 323
+D+S +C+ N+ G+ V+VH +AP ++ P ++
Sbjct: 560 ELDHSGL---FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAAC 616
Query: 324 DVTLTCVWVGN--PPLTLTWTKKDS--------NMVLSNSNQLLLKSVTQADAGTYTCRA 373
D + W + PPL W S + S L ++ V D G YTC A
Sbjct: 617 DPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTC-A 675
Query: 374 IVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGG-KVECFIGSTPPPDRIAW 426
G ++REV L V PP I V AV + +EC PPPD ++W
Sbjct: 676 ATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPD-VSW 728
Score = 70.1 bits (170), Expect = 7e-12
Identities = 123/525 (23%), Positives = 202/525 (38%), Gaps = 105/525 (20%)
Query: 24 SQEPADQ--TVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
+++ AD+ TV L C L + S + W KDG + ++ P
Sbjct: 1352 AEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP---------- 1401
Query: 81 GQYNLEITDAELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTRIDG-GPVILLQAGTP 138
G + L+I +A+ D Y C T E + + VLIPP ++ D G V + + T
Sbjct: 1402 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 1461
Query: 139 HNLT----CRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDI 194
N T C ++ A P TI W++DG Q + ++L +G+ L I PT +
Sbjct: 1462 VNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQVSD 1513
Query: 195 GRVFTCRSMNEAIPSGKETSIELDVHHPPTVT-----------LSIEPQT---------V 234
+ C + N A ++ ++ + V PP LS E + +
Sbjct: 1514 SGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1571
Query: 235 QEGERVVFTCQATA--NPEILGYRW------------AKGGF-----LIEDAHESRYETN 275
E C A P++ YR +GG L+ + RY
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY--- 1628
Query: 276 VDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP----TTTDIGSDVTLTCVW 331
SC+ N+VG + + V P I+ D + T + S V+L C
Sbjct: 1629 ----------SCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPA 1678
Query: 332 VGNPPLTLTW-------TKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE 384
+GNP T++W + VL + L + + ADA +Y C A + G AE+
Sbjct: 1679 LGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA-ENQAGSAEKL 1737
Query: 385 VPLYVNGPPIISSEAVQY--AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYT 442
L V PP I+ ++ A+ + C + + P P+ + W L +G E +
Sbjct: 1738 FTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLGE-EVFL 1795
Query: 443 VERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
+ T+ TL + +D Y C A N+ G ++QL
Sbjct: 1796 LPGTH-------TLQLGRARLSD-SGMYTCEALNAAGRDQKLVQL 1832
Score = 67.4 bits (163), Expect = 5e-11
Identities = 100/366 (27%), Positives = 142/366 (38%), Gaps = 43/366 (11%)
Query: 85 LEITDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPV---ILLQAGTPHN 140
L+I +L D+ Y C AT A S+R L VL+PP I+ GPV +L A
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASV--T 713
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
L C A + P + WF+ G Q + + DG+ L I L + C
Sbjct: 714 LECLA-SGVPPPDVSWFK-GHQPVSSWMGVTVSVDGR------VLRIEQAQLSDAGSYRC 765
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTLSIE-PQTVQEGERVVFTCQATANPEILGYRWAK 259
+ N A E L V+ PP +TL P V V TC AT P W K
Sbjct: 766 VASNVA--GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 822
Query: 260 GGFLIEDAHESRYETNVDYSFFTEP---------VSCEVHNKVGSTNVSTLVNVHFAPRI 310
G + A + T SC + VG ++ VH P I
Sbjct: 823 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 882
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-----VLSNSNQLLLKSVTQA- 364
+ + + V L C PP L+W K + V ++++ LL+ V +A
Sbjct: 883 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ-VDRAD 941
Query: 365 --DAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS-SEAVQYAVR-GDGGKVECFIGSTPP 420
DAG YTC A+ + G +E+ L V P+ E+ VR G + C P
Sbjct: 942 VWDAGHYTCEAL-NQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPF 1000
Query: 421 PDRIAW 426
P +I+W
Sbjct: 1001 P-KISW 1005
Score = 66.6 bits (161), Expect = 8e-11
Identities = 92/381 (24%), Positives = 140/381 (36%), Gaps = 43/381 (11%)
Query: 29 DQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEI 87
D + G A LPC + W KDG + +G ++ + S + NLE
Sbjct: 2855 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEG-----KFTIQPSGELLVKNLEG 2909
Query: 88 TDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAF 146
DA +Y C A A R+RR LT+L+ P T + G + L G L C A
Sbjct: 2910 QDA-----GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAA- 2961
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
P I W T + V +DG +T+ + ++ D + C + N
Sbjct: 2962 RGSPTPRIGW----TVNDRPVTEGVSEQDGG--STLQRAAVSRED---SGTYVCWAENRV 3012
Query: 207 IPSGKETSIE-LDVHHPPTVTLSIEPQTVQE-GERVVFTCQATANPEILGYRWAKGGFLI 264
G+ ++ + V P + V+ G + C +P + W K G +
Sbjct: 3013 ---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPL 3068
Query: 265 EDAHESRYETNVDYSFFTEP------VSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTT 318
+H N + C N++G ++ + AP V+P+ T
Sbjct: 3069 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3128
Query: 319 TDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSN------SNQLLLKSVTQADAGTYTCR 372
G DV L C G P T+ W + + S L L++V DAGTY C
Sbjct: 3129 VRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCV 3188
Query: 373 AIVPRIGVAEREVPLYVNGPP 393
A +G A L V G P
Sbjct: 3189 A-HNLLGSATARAFLVVRGEP 3208
Score = 65.1 bits (157), Expect = 2e-10
Identities = 96/371 (25%), Positives = 148/371 (39%), Gaps = 51/371 (13%)
Query: 48 SGIVQWTKDGLALGMG--QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEA 105
S + W KDG + GL+ +P RV L + A SD Y C A A
Sbjct: 815 SPTLMWLKDGNPVSPAGTPGLQVFPGGRV----------LTLASARASDSGRYSCVAVSA 864
Query: 106 ALRSRR-AKLTVLIPPEDTRIDGGPV-ILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQ 163
R+ L V +PP I G + + + A L C++ +A P + W++DG
Sbjct: 865 VGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQS-HAMPPPVLSWWKDGRPL 920
Query: 164 EGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHP 222
E + G + LL ++ D+ +TC ++N+A S K ++ + V P
Sbjct: 921 EP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVA-P 971
Query: 223 PTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAHESRYETNVDYSFF 281
TV+EG +C+ P W K G L + ++ + V +
Sbjct: 972 VFPLRESHTLTVREGHPTSLSCECRGVP-FPKISWRKDGQPLPGEGAGLQHVSAVGRLLY 1030
Query: 282 TEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVVDPK--PTTTDIGSD--VTLTC 329
+CE N VG+++ + VH P+I P+ PT + D TL C
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI-AGPREPPTQVSVVQDGVATLEC 1089
Query: 330 VWVGNPPLTLTWTK------KDSNMVLSNSNQLL-LKSVTQADAGTYTCRAIVPRIGVAE 382
G PP T+TW + + + L N Q L ++ A G Y+C A G AE
Sbjct: 1090 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA-ENLAGRAE 1148
Query: 383 REVPLYVNGPP 393
R+ L V PP
Sbjct: 1149 RKFELSVLVPP 1159
Score = 61.2 bits (147), Expect = 3e-09
Identities = 105/453 (23%), Positives = 160/453 (35%), Gaps = 80/453 (17%)
Query: 80 AGQYNLEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTP 138
AG + L++T + D Y C A+ A +RR + VL+PP D VI + G
Sbjct: 1212 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQT 1271
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
+L C P + WF+DG A + DG L + +L +
Sbjct: 1272 AHLMCNV-TGHPQPKLTWFKDGRPLARGDAH-HISPDGVL------LQVLQANLSSAGHY 1323
Query: 199 TCRSMNEAIPSGKETS-IELDVHHPPTVTLSIEPQ-----TVQEGERVVFTCQATANPEI 252
+C + N G++T +L V PT+ E TV + C+A A P
Sbjct: 1324 SCIAANAV---GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSP 1380
Query: 253 LGYRWAKGGFLIEDAHESRYETNV-----------DYSFFTEPVSCEVHNKVGSTNVSTL 301
W K G E + + D +T C V N++G +
Sbjct: 1381 -NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYT----CVVTNELGEAVKNYH 1435
Query: 302 VNVHFAPRIVVDP-------KPTTTDIGSDVTLTCVWVGNPPLTLTW-------TKKDSN 347
V V P I D K T + S +TL C PP T+ W T
Sbjct: 1436 VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 1495
Query: 348 MVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS--------EA 399
VL L ++ +D+G Y C A G +++ + + PP+ E
Sbjct: 1496 QVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 1554
Query: 400 VQYAVRGDGGKVE-------------CFIGSTPPPDRIAWAWKENFLEVGTLERYTVERT 446
+ GG E C + PPPD + W ++ L G + +V +
Sbjct: 1555 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPLSAG--DEVSVLQ- 1610
Query: 447 NSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
G VL ++ A+ Y+C A N G
Sbjct: 1611 --GGRVLQI----PLVRAENAGRYSCKASNEVG 1637
Score = 60.5 bits (145), Expect = 6e-09
Identities = 90/398 (22%), Positives = 143/398 (35%), Gaps = 60/398 (15%)
Query: 33 VAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAE 91
VAG+ L CV + S + W +GL + R GS L +
Sbjct: 418 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNE----SRLETDGSV------LRLESPG 467
Query: 92 LSDDASYECQATEAALRS-RRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKP 150
+ Y C A+ A + + + V +PP+ +G + G P L C+A + P
Sbjct: 468 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSP 526
Query: 151 AATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSG 210
TI W ++G E +A ++ G + L I+ +LD +F C++ NEA +G
Sbjct: 527 VPTIQWLQNGRPAE-ELAGVQVASQG------TTLHIDHVELDHSGLFACQATNEAGTAG 579
Query: 211 KETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEI-----------LGYRWAK 259
E + + P V L + G + A +P + L W
Sbjct: 580 AEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS 638
Query: 260 GGFLIEDAHESRYETNVDYSFFTEP--------------VSCEVHNKVGSTNVSTLVNVH 305
G L + T + ++ P +C N G + + V
Sbjct: 639 PGSLWGE------PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL 692
Query: 306 FAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLL 358
P I P + VTL C+ G PP ++W K + V + L +
Sbjct: 693 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 752
Query: 359 KSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS 396
+ +DAG+Y C A G E L VN PP I+
Sbjct: 753 EQAQLSDAGSYRCVA-SNVAGSTELRYGLRVNVPPRIT 789
Score = 57.0 bits (136), Expect = 6e-08
Identities = 79/303 (26%), Positives = 125/303 (41%), Gaps = 35/303 (11%)
Query: 208 PSGKET-SIELDVHHPPTVTLSIEPQ--TVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
P+G++ +L VH PPT+ S E V E V C+A P W K G L+
Sbjct: 294 PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NITWFKDGALL 352
Query: 265 EDAHESRY-------ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVD---P 314
+ + Y + S +C+ N VG+ +T ++V+ P I P
Sbjct: 353 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRP 412
Query: 315 KPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-------LLLKSVTQADAG 367
G V L CV G+P TL+W + + SN ++ L L+S +A +G
Sbjct: 413 YVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSG 472
Query: 368 TYTCRAIVPRIGVAEREVPLYVNGPP-IISSEAVQY--AVRGDGGKVECFIGSTPPPDRI 424
Y+C A P G A + + V PP ++ +E + + G ++ C +P P I
Sbjct: 473 LYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVP-TI 530
Query: 425 AWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAI 484
W E E V+ + G +TL I++V E D + C A N G A
Sbjct: 531 QWLQNGRPAE----ELAGVQVASQG----TTLHIDHV-ELDHSGLFACQATNEAGTAGAE 581
Query: 485 IQL 487
+++
Sbjct: 582 VEV 584
Score = 46.2 bits (108), Expect = 1e-04
Identities = 35/98 (35%), Positives = 46/98 (46%), Gaps = 4/98 (4%)
Query: 64 QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQAT-EAALRSRRAKLTVLIPPED 122
+G + P + G A + +L + +D YECQAT E SRRAKL V +PP
Sbjct: 38 KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP-S 96
Query: 123 TRIDGGPV-ILLQAGTPHNLTCRAFNAKPAATIIWFRD 159
R DG + AG L C A N P I+W +D
Sbjct: 97 IREDGRKANVSGMAGQSLTLECDA-NGFPVPEIVWLKD 133
Score = 43.1 bits (100), Expect = 0.001
Identities = 37/121 (30%), Positives = 50/121 (41%), Gaps = 20/121 (16%)
Query: 324 DVTLT-------CVWVGNPPLTLTWTKKDSN--------MVLSNSNQLLLKSVTQADAGT 368
DV LT C G P +TW K S+ + + L L SV+ AD+G
Sbjct: 12 DVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGD 71
Query: 369 YTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGK---VECFIGSTPPPDRIA 425
Y C+A +G R L V PP I + + V G G+ +EC P P+ I
Sbjct: 72 YECQA-TNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPE-IV 129
Query: 426 W 426
W
Sbjct: 130 W 130
Score = 38.1 bits (87), Expect = 0.030
Identities = 42/133 (31%), Positives = 53/133 (39%), Gaps = 15/133 (11%)
Query: 322 GSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQ---------ADAGTYTCR 372
G+DV L C G P + WT KD VL L ++ Q D G Y C
Sbjct: 232 GADVELQCWTSGVPTPQVEWT-KDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCV 290
Query: 373 AIVPRIGVAEREVPLYVNGPPII--SSEAVQYAVRGDG-GKVECFIGSTPPPDRIAWAWK 429
A P G R+ L V+ PP I S+E + AV D ++ C P P+ I W
Sbjct: 291 AFSP-AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPN-ITWFKD 348
Query: 430 ENFLEVGTLERYT 442
L T YT
Sbjct: 349 GALLPTSTKVVYT 361
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 94.4 bits (233), Expect = 4e-19
Identities = 121/463 (26%), Positives = 189/463 (40%), Gaps = 60/463 (12%)
Query: 31 TVVAGQRAVLPC-VLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
T + LPC V + + V W KD AL +G+ + P G + L++
Sbjct: 2948 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP----------GTHTLQLGR 2997
Query: 90 AELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGP--VILLQAGTPHNLTCRAF 146
A LSD Y C+A AA R ++ +L+VL+PP + GP +L++ G L+C
Sbjct: 2998 ARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET- 3056
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
+A P T+ W++DG Q T+ L+ G+R L I + +++C+ N A
Sbjct: 3057 DALPEPTVTWYKDG-QPLVLAQRTQALRGGQR------LEIQEAQVSDKGLYSCKVSNVA 3109
Query: 207 IPSGKETSIELDVHHPPTVTLSIEPQTVQE--GERVVFTCQATANPEILGYRWAKGGFLI 264
+ + + L V PPT + + +TV + G +V TC + P W K +
Sbjct: 3110 GEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMPV 3165
Query: 265 ED-------AHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
E + R + + +C N +V V APRI
Sbjct: 3166 ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR 3225
Query: 318 TTDI--GSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQLLLKSVTQADA 366
+ G +V L C G PP + W K S + + L+LK + +DA
Sbjct: 3226 EHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 3285
Query: 367 GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEA----VQYAVRGDGGKVECFIGSTPPPD 422
G YTC A P G R + V PP I A + G+ + C + +PP
Sbjct: 3286 GAYTCVAHNP-AGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP-- 3342
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEAD 465
I +W ++ L + +R + GSG TL I+ V AD
Sbjct: 3343 -IHVSWLKDGLPLPLSQRTLLH----GSG--HTLRISKVQLAD 3378
Score = 90.9 bits (224), Expect = 4e-18
Identities = 104/431 (24%), Positives = 170/431 (39%), Gaps = 42/431 (9%)
Query: 79 DAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
++G + EI A +++ +YEC A A + RAK +++ ++ P + + G
Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRA-GTGRAKAQIVVTDPPPQLVPAPNVTVSPGET 533
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
L+CR P + W RD + L D E + I PTD G +
Sbjct: 534 AVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVAQLADLSLEISG----IIPTD---GGRY 585
Query: 199 TCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
C + N S+ L V P V++ Q +G V +C A+ P W+
Sbjct: 586 QCVASN--ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP-TPHISWS 642
Query: 259 KGGFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRI 310
+ +++ +SR + + + V SC+ N+VG+ + + P +
Sbjct: 643 RESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 700
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL----SNSNQLLLKSVTQADA 366
+G + L C G PP + W + M+L S+S +L + + + DA
Sbjct: 701 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDA 760
Query: 367 GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR-GDGGKVECFIGSTPPPDRIA 425
GTYTCRA V +G A E+ L V P ++ V G + C PPP +
Sbjct: 761 GTYTCRA-VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVT 818
Query: 426 WAWKEN---FLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGT 482
W + L +G + +SG L +V D Q Y C A N FG
Sbjct: 819 WRRGDGQPLGLRLGAGRGSRSRQPDSG-----VLFFESVAPED-QAPYVCEARNVFGK-- 870
Query: 483 AIIQLEEREVL 493
+Q E R ++
Sbjct: 871 --VQAEARLIV 879
Score = 89.4 bits (220), Expect = 1e-17
Identities = 122/486 (25%), Positives = 181/486 (37%), Gaps = 51/486 (10%)
Query: 27 PADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNL 85
P V Q A+LPC +V W KD + L PR+ ++ +L
Sbjct: 3679 PPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRS-----PRFEILPEG-----SL 3728
Query: 86 EITDAELSDDASYECQATEAALRSRRAK-LTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
I D Y C A+ +A R+ + L VL PP + L A TP L C
Sbjct: 3729 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN--LTLTAHTPALLPCE 3786
Query: 145 AFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN 204
A + P ++W++DG + + L + R + LL+ F C N
Sbjct: 3787 A-SGSPKPLVVWWKDGQKLD-----FRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN 3840
Query: 205 EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
E + + ++ VH PPT+ TV VV TC +T P W+K G +
Sbjct: 3841 EVGEAHR--LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSWSKAGAQL 3897
Query: 265 EDAHESRY--------ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP 316
A S Y E +C N G + + V +P + P
Sbjct: 3898 -GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSV 3956
Query: 317 TTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL------LKSVTQADAGTYT 370
+V L C G P T+TW K+ N+ S Q+L + + DAG Y
Sbjct: 3957 VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYL 4016
Query: 371 CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYA-VRGDGGKVECFIGSTPPPDRIAWAWK 429
C A G A + L V PP+I + + G + C +P P+ I W K
Sbjct: 4017 CIA-KNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPN-ITWD-K 4073
Query: 430 ENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEE 489
+ G ++T++ + L + N+ D T Y CTA N+ G + L
Sbjct: 4074 DGQPVSGAEGKFTIQPSGE-------LLVKNLEGQDAGT-YTCTAENAVGRARRRVHLTI 4125
Query: 490 REVLPV 495
VLPV
Sbjct: 4126 L-VLPV 4130
Score = 86.3 bits (212), Expect = 1e-16
Identities = 125/504 (24%), Positives = 197/504 (39%), Gaps = 64/504 (12%)
Query: 26 EPADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYN 84
E + +VVA + L C ++ W KDG L PR V SAD
Sbjct: 2076 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE--------PRPGVHLSADKAL-- 2125
Query: 85 LEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
L++ A++ D Y C+A A S + L V + P + + ++ G P +L+C
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHTLTVREGHPTSLSC 2184
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVFTCRS 202
P I W +DG G A + + + V +LL + L +TC
Sbjct: 2185 EC-RGVPFPKISWRKDGQPLPGEGAGLQHV------SAVGRLLYLGQAQLAQEGTYTCEC 2237
Query: 203 MNEAIPSGKETSIELDVHHPPTVTLSIEPQT----VQEGERVVFTCQATANPEILGYRW- 257
N + ++L+VH PP + EP T VQ+G + C AT P W
Sbjct: 2238 SN--VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL-ECNATGKPPPT-VTWE 2293
Query: 258 -------AKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRI 310
A+ G +++ +S + + T SC N G ++V P +
Sbjct: 2294 RDGQPVGAELGLQLQNQGQSLHVERAQAAH-TGRYSCVAENLAGRAERKFELSVLVPPEL 2352
Query: 311 VVDPKPTTT---DIGSDVTLTCVWVGNPPLTLTW-------TKKDSNMVLSNSNQLLLKS 360
+ D P T + S +TL C +G PP + W + + +L+ L +
Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQ 2412
Query: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR---GDGGKVECFIGS 417
+ D+G Y+C A G A R + V PP I +E ++ ++ G + C +
Sbjct: 2413 TQEQDSGLYSCLA-SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTG 2471
Query: 418 TPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNS 477
P P ++ W F + L R S GVL + N+ A HY+C A N+
Sbjct: 2472 HPQP-KLTW-----FKDGRPLARGDAHHI-SPDGVLLQVLQANLSSAG---HYSCIAANA 2521
Query: 478 FGPGTAIIQLEEREVLPVGIIAGA 501
G T QL +L I+ GA
Sbjct: 2522 VGEKTKHFQLS--VLLAPTILGGA 2543
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/420 (26%), Positives = 172/420 (40%), Gaps = 48/420 (11%)
Query: 31 TVVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
TV A L C L N + W ++GL PR +V+ + GQ L+++
Sbjct: 2856 TVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS------PRLQVL---EDGQV-LQVST 2905
Query: 90 AELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNA 148
AE++D ASY C A +A + L V +PP +D V + + +L C +A
Sbjct: 2906 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI-LNSSVSLPCDV-HA 2963
Query: 149 KPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIP 208
P + W++D Q ++ L G + + ++ + + +TC ++N A
Sbjct: 2964 HPNPEVTWYKD--SQALSLGEEVFLLPGTHTLQLGRARLSDSGM-----YTCEALNAA-- 3014
Query: 209 SGKETSIELDVHHPPTVTLSIE-PQ---TVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
+ ++L V PP + PQ V+ G++ V +C+ A PE W K G +
Sbjct: 3015 GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYKDGQPL 3073
Query: 265 EDAHES-------RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
A + R E SC+V N G V T P +PK
Sbjct: 3074 VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA-VRTFTLTVQVPPTFENPKTE 3132
Query: 318 TTD--IGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLLKSVTQADAGT 368
T GS + LTC G P T+TW K + V+S +L L + A AGT
Sbjct: 3133 TVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT 3192
Query: 369 YTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ--YAVRGDGGKVECFIGSTPPPDRIAW 426
YTC A + + V + P I SS + + + G +++C PPPD +AW
Sbjct: 3193 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAW 3251
Score = 85.1 bits (209), Expect = 2e-16
Identities = 122/485 (25%), Positives = 185/485 (38%), Gaps = 62/485 (12%)
Query: 24 SQEPADQTVVAGQRAVLPCVLLNYSGI----VQWTKDGLALGM-GQGLKAWPRYRVVGSA 78
+ + D TV VL C + +GI V W+K G LG G G YRV S
Sbjct: 3860 ADDQTDFTVTMMAPVVLTC---HSTGIPAPTVSWSKAGAQLGARGSG------YRVSPSG 3910
Query: 79 DAGQYNLEITDAELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPVILLQAGT 137
LEI A Y C A +A + + LTV P + V+ A
Sbjct: 3911 A-----LEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS--VVRAVAEE 3963
Query: 138 PHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV 197
L C A + P TI W ++G V ST++L G QL I +
Sbjct: 3964 EVLLPCEA-SGIPRPTITWQKEGLNVATGV-STQVLPGG-------QLRIAHASPEDAGN 4014
Query: 198 FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
+ C + N A + +T + + V PP + + + EG C+A +PE W
Sbjct: 4015 YLCIAKNSAGSAMGKTRLVVQV--PPVIENGLPDLSTTEGSHAFLPCKARGSPEP-NITW 4071
Query: 258 AKGGFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPR 309
K G + A E ++ + + +C N VG + + P
Sbjct: 4072 DKDGQPVSGA-EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV 4130
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-----LLLKSVTQA 364
P + +G + L C G+P + WT D + S Q L +V++
Sbjct: 4131 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE 4190
Query: 365 DAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKV--ECFIGSTPPPD 422
D+GTY C A R+G + ++V P++ EA Y V GG + +C + P PD
Sbjct: 4191 DSGTYVCWA-ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 4249
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGT 482
I W K+ G+ R+ ++ +LTI+ E D Y C A N G
Sbjct: 4250 -IHWI-KDGLPLRGSHLRHQLQN--------GSLTIHRT-ERDDAGRYQCLAENEMGVAK 4298
Query: 483 AIIQL 487
++ L
Sbjct: 4299 KVVIL 4303
Score = 80.5 bits (197), Expect = 5e-15
Identities = 99/392 (25%), Positives = 144/392 (36%), Gaps = 39/392 (9%)
Query: 69 WPRYRVVGSADA-------GQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPE 121
W R +V DA G++ L++ +D Y C A AA S V I
Sbjct: 3615 WHRDGIVLQEDAHTQFPERGRF-LQLQALSTADSGDYSCTARNAA-GSTSVAFRVEIHTV 3672
Query: 122 DTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETT 181
T G P + + L C+A + PA + W +D + E+L +G
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS---- 3727
Query: 182 VSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVV 241
L I P + C + N A +L V PP + S T+ +
Sbjct: 3728 ---LRIQPVLAQDAGHYLCLASNSA--GSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPAL 3782
Query: 242 FTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFF-TEP-------VSCEVHNKV 293
C+A+ +P+ L W G L + Y + T P C V N+V
Sbjct: 3783 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 3842
Query: 294 GSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDS 346
G + V VH P I D T + + V LTC G P T++W+K + S
Sbjct: 3843 GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGS 3902
Query: 347 NMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS-EAVQYAVR 405
+S S L + AG YTC A GVA + V L V P++ +V AV
Sbjct: 3903 GYRVSPSGALEIGQALPIHAGRYTCSA-RNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 3961
Query: 406 GDGGKVECFIGSTPPPDRIAWAWKENFLEVGT 437
+ + C P P W++ L V T
Sbjct: 3962 EEEVLLPCEASGIPRP---TITWQKEGLNVAT 3990
Score = 78.6 bits (192), Expect = 2e-14
Identities = 111/475 (23%), Positives = 185/475 (38%), Gaps = 65/475 (13%)
Query: 31 TVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
TV G+ AVL C +L + + W +D L G RV AD +LEI+
Sbjct: 527 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-------RVAQLADL---SLEISG 576
Query: 90 AELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAK 149
+D Y+C A+ A +R + ++ I Q G ++C A +
Sbjct: 577 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSA-SGY 634
Query: 150 PAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQ--LLINPTDLDIGRVFTCRSMNEAI 207
P I W R+ ++ L++ R +Q L+I + ++C++ NE +
Sbjct: 635 PTPHISWSRE----------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE-V 683
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATA--NPEILGYRWAKGGFLIE 265
+ +ET + L PP+V+ V GE V C+A+ P ++ W +GG +
Sbjct: 684 GTDQET-VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI---WYRGGLEMI 739
Query: 266 DAHESRYETNVDYSFFTE----PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDI 321
A E + E +C N++G + + V AP++ P+ T ++
Sbjct: 740 LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL 799
Query: 322 GSDVTLTCVWVGNPPLTLTWTKKD-------------SNMVLSNSNQLLLKSVTQADAGT 368
G L C G PP T+TW + D S +S L +SV D
Sbjct: 800 GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 859
Query: 369 YTCRAIVPRIGVAEREVPLYVNG---PPIISSEAVQYAVRGDGGKVECFI-GSTPPPDRI 424
Y C A G + E L V G P I SS + G + C + P P+R
Sbjct: 860 YVCEA-RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER- 917
Query: 425 AWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
W ++ + R+++ S L ++ ++ + Y+C A N+ G
Sbjct: 918 --HWLKDGRPLPPGSRHSIRADGS-------LHLDRALQ-EHAGRYSCVATNTAG 962
Score = 77.4 bits (189), Expect = 5e-14
Identities = 93/379 (24%), Positives = 138/379 (36%), Gaps = 43/379 (11%)
Query: 32 VVAGQRAVLPCVLLNYSGI----VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEI 87
V G+ AVL C SG+ V W + GL + ++ + L I
Sbjct: 709 VAVGEEAVLVC---EASGVPPPRVIWYRGGLEM-------------ILAPEGSSSGKLRI 752
Query: 88 TDAELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAF 146
A+ D +Y C+A E S +L V P+ T + + ++ G L CRA
Sbjct: 753 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD--VTVELGRSALLACRA- 809
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
+P T+ W R Q G R+ L + + C + N
Sbjct: 810 TGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 868
Query: 207 IPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIED 266
E + + H PP + S V EG+ V C A + W K G +
Sbjct: 869 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 928
Query: 267 AHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTT 318
SR+ D S + SC N GS + + V PRI
Sbjct: 929 G--SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI 986
Query: 319 TDIGSDVTLTCVWVGNPPLTLTWTKKDSNMV-------LSNSNQLLLKSVTQADAGTYTC 371
T+ G +L CV G P T+TWTK+ + + +S LL+ + DAG Y C
Sbjct: 987 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 1046
Query: 372 RAIVPRIGVAEREVPLYVN 390
A +G + +E+ L VN
Sbjct: 1047 TA-TNTVGFSSQEMRLSVN 1064
Score = 76.6 bits (187), Expect = 8e-14
Identities = 110/451 (24%), Positives = 171/451 (37%), Gaps = 44/451 (9%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110
V W KDG LG G P R D G +L + SD +Y C A A
Sbjct: 3249 VAWLKDGSPLGQDMG----PHLRFY--LDGG--SLVLKGLRASDAGAYTCVAHNPAGEDA 3300
Query: 111 RAK-LTVLIPPEDTR-IDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVA 168
R + VL+PP + DG ++ + G + C P + W +DG
Sbjct: 3301 RLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPPIHVSWLKDGLPLP---L 3356
Query: 169 STELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLS 228
S L G T L I+ L +FTC + + A + + ++++ V P V
Sbjct: 3357 SQRTLLHGSGHT----LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV---PPVLEP 3409
Query: 229 IEPQT---VQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAHESRYETNVDY--SFFT 282
+E Q V G V C+A P L W K G L+ + E ++ + +
Sbjct: 3410 VEFQNDVVVVRGSLVELPCEARGVPLPL-VSWMKDGEPLLSQSLEQGPSLQLEAVGAGDS 3468
Query: 283 EPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDI--GSDVTLTCVWVGNPPLTLT 340
SC ++ G + V P I +PT + G+ + L C G P +T
Sbjct: 3469 GTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT 3528
Query: 341 WTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP-IISSEA 399
W K + +N + + DAG YTC A P G E+ + V PP I+
Sbjct: 3529 WHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESP-AGAIEKSFRVRVQAPPNIVGPRG 3587
Query: 400 VQYAVRGDGGK--VECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT 457
++ V G+ +EC + + P P +I W L+ ++ LST
Sbjct: 3588 PRFVVGLAPGQLVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTAD 3646
Query: 458 INNVMEADFQTHYNCTAWNSFGPGTAIIQLE 488
+ Y+CTA N+ G + ++E
Sbjct: 3647 SGD---------YSCTARNAAGSTSVAFRVE 3668
Score = 72.0 bits (175), Expect = 2e-12
Identities = 122/492 (24%), Positives = 193/492 (39%), Gaps = 56/492 (11%)
Query: 28 ADQTVVAGQRAVLPCVLLNYS-GIVQWTKDGLALGMGQGLKA------WPRYRVVGSADA 80
A+ + +AGQ L C + + W KD +G+ G W + D
Sbjct: 1308 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 1367
Query: 81 GQYNLEITDAELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPH 139
GQ +L + D Y C+A +A R L VL PP +L AG
Sbjct: 1368 GQ-SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 1426
Query: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDL-DIGRVF 198
L C + P + W +D ++ +DG+ L I + + D GR +
Sbjct: 1427 ELQCWT-SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ------VLRITGSHVGDEGR-Y 1478
Query: 199 TCRSMNEAIPSGKET-SIELDVHHPPTVTLSIEPQ--TVQEGERVVFTCQATANPEILGY 255
C + + P+G++ +L VH PPT+ S E V E V C+A P
Sbjct: 1479 QCVAFS---PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NI 1534
Query: 256 RWAKGGFLIEDAHESRY-------ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAP 308
W K G L+ + + Y + S +C+ N VG+ +T ++V+ P
Sbjct: 1535 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 1594
Query: 309 RIVVD---PKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-------LLL 358
I P G V L CV G+P TL+W + + SN ++ L L
Sbjct: 1595 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRL 1654
Query: 359 KSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP-IISSEAVQY--AVRGDGGKVECFI 415
+S +A +G Y+C A P G A + + V PP ++ +E + + G ++ C
Sbjct: 1655 ESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 1713
Query: 416 GSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAW 475
+P P I W E E V+ + G +TL I++V E D + C A
Sbjct: 1714 SGSPVP-TIQWLQNGRPAE----ELAGVQVASQG----TTLHIDHV-ELDHSGLFACQAT 1763
Query: 476 NSFGPGTAIIQL 487
N G A +++
Sbjct: 1764 NEAGTAGAEVEV 1775
Score = 70.9 bits (172), Expect = 4e-12
Identities = 93/399 (23%), Positives = 148/399 (37%), Gaps = 70/399 (17%)
Query: 69 WPRYRVVGSADAGQYNLEITDAELSDDASYECQATE-AALRSRRAKLTVLIPPEDTRIDG 127
W Y ++ S +L + ++ D YEC A+ A S R L V +PP+ +
Sbjct: 1073 WEEYGLLPSG-----SLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQ---VQP 1124
Query: 128 GP-VILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLL 186
GP V+ + G +L C A P + W +DG +G + R +
Sbjct: 1125 GPRVLKVLVGEALDLNCVA-EGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIRTS------ 1177
Query: 187 INPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPP----TVTLSIEPQTVQEGERVVF 242
D GR + C + N A E +EL V PP T + + E +
Sbjct: 1178 ------DAGR-YRCEASNSAGVDAWE--VELRVLEPPHWGADETSGLLERVAGENASLPC 1228
Query: 243 TCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVG 294
+ T P++ W KG + + S F VS C+ N+VG
Sbjct: 1229 PARGTPKPQV---TWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 1285
Query: 295 STNVSTLVNVHFAPRIVVDPKPTTTD--IGSDVTLTC----------VWVGNPPLT---- 338
ST+ + V+ P I D + G +TL C VW+ + L
Sbjct: 1286 STSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPL 1345
Query: 339 --------LTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVN 390
L W + + +L L + + D+G Y+CRA + G A+R+ L V
Sbjct: 1346 GWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA-ENQAGTAQRDFHLLVL 1404
Query: 391 GPPIISSEAVQYAVRGDGG---KVECFIGSTPPPDRIAW 426
PP + V G G +++C+ P P ++ W
Sbjct: 1405 TPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTP-QVEW 1442
Score = 70.1 bits (170), Expect = 7e-12
Identities = 123/525 (23%), Positives = 202/525 (38%), Gaps = 105/525 (20%)
Query: 24 SQEPADQ--TVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
+++ AD+ TV L C L + S + W KDG + ++ P
Sbjct: 2543 AEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP---------- 2592
Query: 81 GQYNLEITDAELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTRIDG-GPVILLQAGTP 138
G + L+I +A+ D Y C T E + + VLIPP ++ D G V + + T
Sbjct: 2593 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTK 2652
Query: 139 HNLT----CRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDI 194
N T C ++ A P TI W++DG Q + ++L +G+ L I PT +
Sbjct: 2653 VNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQVSD 2704
Query: 195 GRVFTCRSMNEAIPSGKETSIELDVHHPPTVT-----------LSIEPQT---------V 234
+ C + N A ++ ++ + V PP LS E + +
Sbjct: 2705 SGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTEYREI 2762
Query: 235 QEGERVVFTCQATA--NPEILGYRW------------AKGGF-----LIEDAHESRYETN 275
E C A P++ YR +GG L+ + RY
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY--- 2819
Query: 276 VDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP----TTTDIGSDVTLTCVW 331
SC+ N+VG + + V P I+ D + T + S V+L C
Sbjct: 2820 ----------SCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPA 2869
Query: 332 VGNPPLTLTW-------TKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE 384
+GNP T++W + VL + L + + ADA +Y C A + G AE+
Sbjct: 2870 LGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA-ENQAGSAEKL 2928
Query: 385 VPLYVNGPPIISSEAVQY--AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYT 442
L V PP I+ ++ A+ + C + + P P+ + W L +G E +
Sbjct: 2929 FTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLGE-EVFL 2986
Query: 443 VERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
+ T+ TL + +D Y C A N+ G ++QL
Sbjct: 2987 LPGTH-------TLQLGRARLSD-SGMYTCEALNAAGRDQKLVQL 3023
Score = 67.4 bits (163), Expect = 5e-11
Identities = 100/366 (27%), Positives = 142/366 (38%), Gaps = 43/366 (11%)
Query: 85 LEITDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPV---ILLQAGTPHN 140
L+I +L D+ Y C AT A S+R L VL+PP I+ GPV +L A
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASV--T 1904
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
L C A + P + WF+ G Q + + DG+ L I L + C
Sbjct: 1905 LECLA-SGVPPPDVSWFK-GHQPVSSWMGVTVSVDGR------VLRIEQAQLSDAGSYRC 1956
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTLSIE-PQTVQEGERVVFTCQATANPEILGYRWAK 259
+ N A E L V+ PP +TL P V V TC AT P W K
Sbjct: 1957 VASNVA--GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 2013
Query: 260 GGFLIEDAHESRYETNVDYSFFTEP---------VSCEVHNKVGSTNVSTLVNVHFAPRI 310
G + A + T SC + VG ++ VH P I
Sbjct: 2014 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 2073
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-----VLSNSNQLLLKSVTQA- 364
+ + + V L C PP L+W K + V ++++ LL+ V +A
Sbjct: 2074 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ-VDRAD 2132
Query: 365 --DAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS-SEAVQYAVR-GDGGKVECFIGSTPP 420
DAG YTC A+ + G +E+ L V P+ E+ VR G + C P
Sbjct: 2133 VWDAGHYTCEAL-NQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPF 2191
Query: 421 PDRIAW 426
P +I+W
Sbjct: 2192 P-KISW 2196
Score = 66.6 bits (161), Expect = 8e-11
Identities = 92/381 (24%), Positives = 140/381 (36%), Gaps = 43/381 (11%)
Query: 29 DQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEI 87
D + G A LPC + W KDG + +G ++ + S + NLE
Sbjct: 4046 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEG-----KFTIQPSGELLVKNLEG 4100
Query: 88 TDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAF 146
DA +Y C A A R+RR LT+L+ P T + G + L G L C A
Sbjct: 4101 QDA-----GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAA- 4152
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
P I W T + V +DG +T+ + ++ D + C + N
Sbjct: 4153 RGSPTPRIGW----TVNDRPVTEGVSEQDGG--STLQRAAVSRED---SGTYVCWAENRV 4203
Query: 207 IPSGKETSIE-LDVHHPPTVTLSIEPQTVQE-GERVVFTCQATANPEILGYRWAKGGFLI 264
G+ ++ + V P + V+ G + C +P + W K G +
Sbjct: 4204 ---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPL 4259
Query: 265 EDAHESRYETNVDYSFFTEP------VSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTT 318
+H N + C N++G ++ + AP V+P+ T
Sbjct: 4260 RGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 4319
Query: 319 TDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSN------SNQLLLKSVTQADAGTYTCR 372
G DV L C G P T+ W + + S L L++V DAGTY C
Sbjct: 4320 VRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCV 4379
Query: 373 AIVPRIGVAEREVPLYVNGPP 393
A +G A L V G P
Sbjct: 4380 A-HNLLGSATARAFLVVRGEP 4399
Score = 65.1 bits (157), Expect = 2e-10
Identities = 96/371 (25%), Positives = 148/371 (39%), Gaps = 51/371 (13%)
Query: 48 SGIVQWTKDGLALGMG--QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEA 105
S + W KDG + GL+ +P RV L + A SD Y C A A
Sbjct: 2006 SPTLMWLKDGNPVSPAGTPGLQVFPGGRV----------LTLASARASDSGRYSCVAVSA 2055
Query: 106 ALRSRR-AKLTVLIPPEDTRIDGGPV-ILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQ 163
R+ L V +PP I G + + + A L C++ +A P + W++DG
Sbjct: 2056 VGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQS-HAMPPPVLSWWKDGRPL 2111
Query: 164 EGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHP 222
E + G + LL ++ D+ +TC ++N+A S K ++ + V P
Sbjct: 2112 EP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA-P 2162
Query: 223 PTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAHESRYETNVDYSFF 281
TV+EG +C+ P W K G L + ++ + V +
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSCECRGVP-FPKISWRKDGQPLPGEGAGLQHVSAVGRLLY 2221
Query: 282 TEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVVDPK--PTTTDIGSD--VTLTC 329
+CE N VG+++ + VH P+I P+ PT + D TL C
Sbjct: 2222 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI-AGPREPPTQVSVVQDGVATLEC 2280
Query: 330 VWVGNPPLTLTWTK------KDSNMVLSNSNQLL-LKSVTQADAGTYTCRAIVPRIGVAE 382
G PP T+TW + + + L N Q L ++ A G Y+C A G AE
Sbjct: 2281 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA-ENLAGRAE 2339
Query: 383 REVPLYVNGPP 393
R+ L V PP
Sbjct: 2340 RKFELSVLVPP 2350
Score = 61.2 bits (147), Expect = 3e-09
Identities = 105/453 (23%), Positives = 160/453 (35%), Gaps = 80/453 (17%)
Query: 80 AGQYNLEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTP 138
AG + L++T + D Y C A+ A +RR + VL+PP D VI + G
Sbjct: 2403 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQT 2462
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
+L C P + WF+DG A + DG L + +L +
Sbjct: 2463 AHLMCNV-TGHPQPKLTWFKDGRPLARGDAH-HISPDGVL------LQVLQANLSSAGHY 2514
Query: 199 TCRSMNEAIPSGKETS-IELDVHHPPTVTLSIEPQ-----TVQEGERVVFTCQATANPEI 252
+C + N G++T +L V PT+ E TV + C+A A P
Sbjct: 2515 SCIAANAV---GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSP 2571
Query: 253 LGYRWAKGGFLIEDAHESRYETNV-----------DYSFFTEPVSCEVHNKVGSTNVSTL 301
W K G E + + D +T C V N++G +
Sbjct: 2572 -NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYT----CVVTNELGEAVKNYH 2626
Query: 302 VNVHFAPRIVVDP-------KPTTTDIGSDVTLTCVWVGNPPLTLTW-------TKKDSN 347
V V P I D K T + S +TL C PP T+ W T
Sbjct: 2627 VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 2686
Query: 348 MVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS--------EA 399
VL L ++ +D+G Y C A G +++ + + PP+ E
Sbjct: 2687 QVLGEGRLLQIQPTQVSDSGRYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 2745
Query: 400 VQYAVRGDGGKVE-------------CFIGSTPPPDRIAWAWKENFLEVGTLERYTVERT 446
+ GG E C + PPPD + W ++ L G + +V +
Sbjct: 2746 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPLSAG--DEVSVLQ- 2801
Query: 447 NSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
G VL ++ A+ Y+C A N G
Sbjct: 2802 --GGRVLQI----PLVRAENAGRYSCKASNEVG 2828
Score = 60.5 bits (145), Expect = 6e-09
Identities = 90/398 (22%), Positives = 143/398 (35%), Gaps = 60/398 (15%)
Query: 33 VAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAE 91
VAG+ L CV + S + W +GL + R GS L +
Sbjct: 1609 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNE----SRLETDGSV------LRLESPG 1658
Query: 92 LSDDASYECQATEAALRS-RRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKP 150
+ Y C A+ A + + + V +PP+ +G + G P L C+A + P
Sbjct: 1659 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSP 1717
Query: 151 AATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSG 210
TI W ++G E +A ++ G + L I+ +LD +F C++ NEA +G
Sbjct: 1718 VPTIQWLQNGRPAE-ELAGVQVASQG------TTLHIDHVELDHSGLFACQATNEAGTAG 1770
Query: 211 KETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEI-----------LGYRWAK 259
E + + P V L + G + A +P + L W
Sbjct: 1771 AEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS 1829
Query: 260 GGFLIEDAHESRYETNVDYSFFTEP--------------VSCEVHNKVGSTNVSTLVNVH 305
G L + T + ++ P +C N G + + V
Sbjct: 1830 PGSLWGE------PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL 1883
Query: 306 FAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLL 358
P I P + VTL C+ G PP ++W K + V + L +
Sbjct: 1884 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 1943
Query: 359 KSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS 396
+ +DAG+Y C A G E L VN PP I+
Sbjct: 1944 EQAQLSDAGSYRCVA-SNVAGSTELRYGLRVNVPPRIT 1980
Score = 58.9 bits (141), Expect = 2e-08
Identities = 110/453 (24%), Positives = 172/453 (37%), Gaps = 73/453 (16%)
Query: 32 VVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDA 90
V+ G+ L CV N + W+KDG+ L G+G + + + ++DAG+Y
Sbjct: 1131 VLVGEALDLNCVAEGNPEPQLSWSKDGVVL-QGRGPQGSVHFAAIRTSDAGRY------- 1182
Query: 91 ELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAK 149
C+A+ +A + + +L VL PP + ++ AG +L C A
Sbjct: 1183 --------RCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPA-RGT 1233
Query: 150 PAATIIWFRDGTQQE--GAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAI 207
P + W R G E +L++G S L + + D G + C++ NE
Sbjct: 1234 PKPQVTW-RKGPSSEPLHGQPGVAVLEEG------SLFLASVSPADSGD-YECQATNEVG 1285
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTV--QEGERVVFTCQATA--NPEIL---------- 253
+ + +L V+ PP++ V G+ + C A PEI+
Sbjct: 1286 STSRRA--KLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGV 1343
Query: 254 -----GYRW-----AKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVN 303
GY W GG + D +S + + + SC N+ G+ +
Sbjct: 1344 PLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG-DSGLYSCRAENQAGTAQRDFHLL 1402
Query: 304 VHFAPRIV--VDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSV 361
V P ++ + G+DV L C G P + WT KD VL L ++
Sbjct: 1403 VLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWT-KDRQPVLPGGPHLQVQED 1461
Query: 362 TQ---------ADAGTYTCRAIVPRIGVAEREVPLYVNGPPII--SSEAVQYAVRGDG-G 409
Q D G Y C A P G R+ L V+ PP I S+E + AV D
Sbjct: 1462 GQVLRITGSHVGDEGRYQCVAFSP-AGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLV 1520
Query: 410 KVECFIGSTPPPDRIAWAWKENFLEVGTLERYT 442
++ C P P+ I W L T YT
Sbjct: 1521 QLLCEARGVPTPN-ITWFKDGALLPTSTKVVYT 1552
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/235 (22%), Positives = 82/235 (34%), Gaps = 23/235 (9%)
Query: 287 CEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDS 346
C ++ G+ + V P +V T G L+C +G P LTW +
Sbjct: 496 CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR 555
Query: 347 NMVLSNSN-------QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS-SE 398
+ S L + + D G Y C A GV V L V P +S
Sbjct: 556 VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN-GVTRASVWLLVREAPQVSIHT 614
Query: 399 AVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTI 458
+ Q+ +G KV C P P I+W+ + L+ E + TL I
Sbjct: 615 SSQHFSQGVEVKVSCSASGYPTP-HISWSRESQALQ---------EDSRIHVDAQGTLII 664
Query: 459 NNVMEADFQTHYNCTAWNSFGPGTAIIQL---EEREVLPVGIIAGATIGASILLI 510
V D +Y+C A N G + L + V V + +G +L+
Sbjct: 665 QGVAPED-AGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 718
Score = 41.6 bits (96), Expect = 0.003
Identities = 57/240 (23%), Positives = 85/240 (35%), Gaps = 26/240 (10%)
Query: 18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTK-DGLALGMGQGLKAWPRYRVV 75
G + ++ P D TV G+ A+L C V W + DG LG+ G R R
Sbjct: 783 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR-- 840
Query: 76 GSADAGQYNLEITDAELSDDASYECQATEA---ALRSRRAKLTVLIPPEDTRIDGGPVIL 132
D+G E E D A Y C+A R +T PP+ P +
Sbjct: 841 -QPDSGVLFFESVAPE--DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA--SSAPTVR 895
Query: 133 LQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET--TVSQLLINPT 190
+ G P +L C +P W +DG L G R + L ++
Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERHWLKDGRP----------LPPGSRHSIRADGSLHLDRA 945
Query: 191 DLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANP 250
+ ++C + N A + +EL V PP + + EG C A+ P
Sbjct: 946 LQEHAGRYSCVATNTA--GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVP 1003
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 94.4 bits (233), Expect = 4e-19
Identities = 121/463 (26%), Positives = 189/463 (40%), Gaps = 60/463 (12%)
Query: 31 TVVAGQRAVLPC-VLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
T + LPC V + + V W KD AL +G+ + P G + L++
Sbjct: 1666 TAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP----------GTHTLQLGR 1715
Query: 90 AELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGP--VILLQAGTPHNLTCRAF 146
A LSD Y C+A AA R ++ +L+VL+PP + GP +L++ G L+C
Sbjct: 1716 ARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCET- 1774
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
+A P T+ W++DG Q T+ L+ G+R L I + +++C+ N A
Sbjct: 1775 DALPEPTVTWYKDG-QPLVLAQRTQALRGGQR------LEIQEAQVSDKGLYSCKVSNVA 1827
Query: 207 IPSGKETSIELDVHHPPTVTLSIEPQTVQE--GERVVFTCQATANPEILGYRWAKGGFLI 264
+ + + L V PPT + + +TV + G +V TC + P W K +
Sbjct: 1828 GEAVR--TFTLTVQVPPTFE-NPKTETVSQVAGSPLVLTCDVSGVPAPT-VTWLKDRMPV 1883
Query: 265 ED-------AHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
E + R + + +C N +V V APRI
Sbjct: 1884 ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR 1943
Query: 318 TTDI--GSDVTLTCVWVGNPPLTLTWTKKDSNM---------VLSNSNQLLLKSVTQADA 366
+ G +V L C G PP + W K S + + L+LK + +DA
Sbjct: 1944 EHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA 2003
Query: 367 GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEA----VQYAVRGDGGKVECFIGSTPPPD 422
G YTC A P G R + V PP I A + G+ + C + +PP
Sbjct: 2004 GAYTCVAHNP-AGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP-- 2060
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEAD 465
I +W ++ L + +R + GSG TL I+ V AD
Sbjct: 2061 -IHVSWLKDGLPLPLSQRTLLH----GSG--HTLRISKVQLAD 2096
Score = 89.4 bits (220), Expect = 1e-17
Identities = 122/486 (25%), Positives = 181/486 (37%), Gaps = 51/486 (10%)
Query: 27 PADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNL 85
P V Q A+LPC +V W KD + L PR+ ++ +L
Sbjct: 2397 PPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRS-----PRFEILPEG-----SL 2446
Query: 86 EITDAELSDDASYECQATEAALRSRRAK-LTVLIPPEDTRIDGGPVILLQAGTPHNLTCR 144
I D Y C A+ +A R+ + L VL PP + L A TP L C
Sbjct: 2447 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN--LTLTAHTPALLPCE 2504
Query: 145 AFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMN 204
A + P ++W++DG + + L + R + LL+ F C N
Sbjct: 2505 A-SGSPKPLVVWWKDGQKLD-----FRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSN 2558
Query: 205 EAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
E + + ++ VH PPT+ TV VV TC +T P W+K G +
Sbjct: 2559 EVGEAHR--LYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPT-VSWSKAGAQL 2615
Query: 265 EDAHESRY--------ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP 316
A S Y E +C N G + + V +P + P
Sbjct: 2616 -GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSV 2674
Query: 317 TTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLL------LKSVTQADAGTYT 370
+V L C G P T+TW K+ N+ S Q+L + + DAG Y
Sbjct: 2675 VRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYL 2734
Query: 371 CRAIVPRIGVAEREVPLYVNGPPIISSEAVQYA-VRGDGGKVECFIGSTPPPDRIAWAWK 429
C A G A + L V PP+I + + G + C +P P+ I W K
Sbjct: 2735 CIA-KNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPN-ITWD-K 2791
Query: 430 ENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEE 489
+ G ++T++ + L + N+ D T Y CTA N+ G + L
Sbjct: 2792 DGQPVSGAEGKFTIQPSGE-------LLVKNLEGQDAGT-YTCTAENAVGRARRRVHLTI 2843
Query: 490 REVLPV 495
VLPV
Sbjct: 2844 L-VLPV 2848
Score = 85.9 bits (211), Expect = 1e-16
Identities = 125/504 (24%), Positives = 196/504 (38%), Gaps = 64/504 (12%)
Query: 26 EPADQTVVAGQRAVLPCVLLNYSG-IVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYN 84
E + +VVA + L C ++ W KDG L PR V SAD
Sbjct: 794 EELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE--------PRPGVHLSADKAL-- 843
Query: 85 LEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
L++ A++ D Y C+A A S + L V + P + + ++ G P L+C
Sbjct: 844 LQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHTLTVREGHPTRLSC 902
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVFTCRS 202
P I W +DG G A + + + V +LL + L +TC
Sbjct: 903 EC-RGVPFPKISWRKDGQPLPGEGAGLQHV------SAVGRLLYLGQAQLAQEGTYTCEC 955
Query: 203 MNEAIPSGKETSIELDVHHPPTVTLSIEPQT----VQEGERVVFTCQATANPEILGYRW- 257
N + ++L+VH PP + EP T VQ+G + C AT P W
Sbjct: 956 SN--VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATL-ECNATGKPPPT-VTWE 1011
Query: 258 -------AKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRI 310
A+ G +++ +S + + T SC N G ++V P +
Sbjct: 1012 RDGQPVGAELGLQLQNQGQSLHVERAQAAH-TGRYSCVAENLAGRAERKFELSVLVPPEL 1070
Query: 311 VVDPKPTTT---DIGSDVTLTCVWVGNPPLTLTW-------TKKDSNMVLSNSNQLLLKS 360
+ D P T + S +TL C +G PP + W + + +L+ L +
Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQ 1130
Query: 361 VTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR---GDGGKVECFIGS 417
+ D+G Y+C A G A R + V PP I +E ++ ++ G + C +
Sbjct: 1131 TQEQDSGLYSCLA-SNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTG 1189
Query: 418 TPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNS 477
P P ++ W F + L R S GVL + N+ A HY+C A N+
Sbjct: 1190 HPQP-KLTW-----FKDGRPLARGDAHHI-SPDGVLLQVLQANLSSAG---HYSCIAANA 1239
Query: 478 FGPGTAIIQLEEREVLPVGIIAGA 501
G T QL +L I+ GA
Sbjct: 1240 VGEKTKHFQLS--VLLAPTILGGA 1261
Score = 85.5 bits (210), Expect = 2e-16
Identities = 110/420 (26%), Positives = 172/420 (40%), Gaps = 48/420 (11%)
Query: 31 TVVAGQRAVLPCVLL-NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
TV A L C L N + W ++GL PR +V+ + GQ L+++
Sbjct: 1574 TVNASSTVSLQCPALGNPVPTISWLQNGLPFSPS------PRLQVL---EDGQV-LQVST 1623
Query: 90 AELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNA 148
AE++D ASY C A +A + L V +PP +D V + + +L C +A
Sbjct: 1624 AEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAI-LNSSVSLPCDV-HA 1681
Query: 149 KPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIP 208
P + W++D Q ++ L G + + ++ + + +TC ++N A
Sbjct: 1682 HPNPEVTWYKD--SQALSLGEEVFLLPGTHTLQLGRARLSDSGM-----YTCEALNAA-- 1732
Query: 209 SGKETSIELDVHHPPTVTLSIE-PQ---TVQEGERVVFTCQATANPEILGYRWAKGGFLI 264
+ ++L V PP + PQ V+ G++ V +C+ A PE W K G +
Sbjct: 1733 GRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPT-VTWYKDGQPL 1791
Query: 265 EDAHES-------RYETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPT 317
A + R E SC+V N G V T P +PK
Sbjct: 1792 VLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA-VRTFTLTVQVPPTFENPKTE 1850
Query: 318 TTD--IGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLLKSVTQADAGT 368
T GS + LTC G P T+TW K + V+S +L L + A AGT
Sbjct: 1851 TVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGT 1910
Query: 369 YTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQ--YAVRGDGGKVECFIGSTPPPDRIAW 426
YTC A + + V + P I SS + + + G +++C PPPD +AW
Sbjct: 1911 YTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPD-VAW 1969
Score = 84.7 bits (208), Expect = 3e-16
Identities = 122/485 (25%), Positives = 184/485 (37%), Gaps = 62/485 (12%)
Query: 24 SQEPADQTVVAGQRAVLPCVLLNYSGI----VQWTKDGLALGM-GQGLKAWPRYRVVGSA 78
+ + D TV VL C + +GI V W+K G LG G G YRV S
Sbjct: 2578 ADDQTDFTVTMMAPVVLTC---HSTGIPAPTVSWSKAGAQLGARGSG------YRVSPSG 2628
Query: 79 DAGQYNLEITDAELSDDASYECQATEAA-LRSRRAKLTVLIPPEDTRIDGGPVILLQAGT 137
LEI A Y C A +A + + LTV P + V+ A
Sbjct: 2629 A-----LEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPS--VVRAVAEE 2681
Query: 138 PHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRV 197
L C A + P TI W ++G V ST++L G QL I +
Sbjct: 2682 EVLLPCEA-SGIPRPTITWQKEGLNVATGV-STQVLPGG-------QLRIAHASPEDAGN 2732
Query: 198 FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
+ C + N A + +T + + V PP + + + EG C+A +PE W
Sbjct: 2733 YLCIAKNSAGSAMGKTRLVVQV--PPVIENGLPDLSTTEGSHAFLPCKARGSPEP-NITW 2789
Query: 258 AKGGFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPR 309
K G + A E ++ + + +C N VG + + P
Sbjct: 2790 DKDGQPVSGA-EGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPV 2848
Query: 310 IVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-----LLLKSVTQA 364
P + +G + L C G+P + WT D + S Q L +V++
Sbjct: 2849 FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSRE 2908
Query: 365 DAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDGGKV--ECFIGSTPPPD 422
D+GTY C A R+G + ++V P++ EA Y V GG + +C + P PD
Sbjct: 2909 DSGTYVCWA-ENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPD 2967
Query: 423 RIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGT 482
I W K+ G+ R+ ++ +LTI E D Y C A N G
Sbjct: 2968 -IHWI-KDGLPLRGSHLRHQLQN--------GSLTIRRT-ERDDAGRYQCLAENEMGVAK 3016
Query: 483 AIIQL 487
++ L
Sbjct: 3017 KVVIL 3021
Score = 80.5 bits (197), Expect = 5e-15
Identities = 99/392 (25%), Positives = 144/392 (36%), Gaps = 39/392 (9%)
Query: 69 WPRYRVVGSADA-------GQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPE 121
W R +V DA G++ L++ +D Y C A AA S V I
Sbjct: 2333 WHRDGIVLQEDAHTQFPERGRF-LQLQALSTADSGDYSCTARNAA-GSTSVAFRVEIHTV 2390
Query: 122 DTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETT 181
T G P + + L C+A + PA + W +D + E+L +G
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQA-DGVPAPLVSWRKDRVPLDPRSPRFEILPEGS---- 2445
Query: 182 VSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVV 241
L I P + C + N A +L V PP + S T+ +
Sbjct: 2446 ---LRIQPVLAQDAGHYLCLASNSA--GSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPAL 2500
Query: 242 FTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFF-TEP-------VSCEVHNKV 293
C+A+ +P+ L W G L + Y + T P C V N+V
Sbjct: 2501 LPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEV 2560
Query: 294 GSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDS 346
G + V VH P I D T + + V LTC G P T++W+K + S
Sbjct: 2561 GEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGS 2620
Query: 347 NMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS-EAVQYAVR 405
+S S L + AG YTC A GVA + V L V P++ +V AV
Sbjct: 2621 GYRVSPSGALEIGQALPIHAGRYTCSA-RNSAGVAHKHVFLTVQASPVVKPLPSVVRAVA 2679
Query: 406 GDGGKVECFIGSTPPPDRIAWAWKENFLEVGT 437
+ + C P P W++ L V T
Sbjct: 2680 EEEVLLPCEASGIPRP---TITWQKEGLNVAT 2708
Score = 76.6 bits (187), Expect = 8e-14
Identities = 110/451 (24%), Positives = 171/451 (37%), Gaps = 44/451 (9%)
Query: 51 VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSR 110
V W KDG LG G P R D G +L + SD +Y C A A
Sbjct: 1967 VAWLKDGSPLGQDMG----PHLRFY--LDGG--SLVLKGLRASDAGAYTCVAHNPAGEDA 2018
Query: 111 RAK-LTVLIPPEDTR-IDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVA 168
R + VL+PP + DG ++ + G + C P + W +DG
Sbjct: 2019 RLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPV-RGSPPIHVSWLKDGLPLP---L 2074
Query: 169 STELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLS 228
S L G T L I+ L +FTC + + A + + ++++ V P V
Sbjct: 2075 SQRTLLHGSGHT----LRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV---PPVLEP 2127
Query: 229 IEPQT---VQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAHESRYETNVDY--SFFT 282
+E Q V G V C+A P L W K G L+ + E ++ + +
Sbjct: 2128 VEFQNDVVVVRGSLVELPCEARGVPLPL-VSWMKDGEPLLSQSLEQGPSLQLEAVGAGDS 2186
Query: 283 EPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDI--GSDVTLTCVWVGNPPLTLT 340
SC ++ G + V P I +PT + G+ + L C G P +T
Sbjct: 2187 GTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNIT 2246
Query: 341 WTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP-IISSEA 399
W K + +N + + DAG YTC A P G E+ + V PP I+
Sbjct: 2247 WHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESP-AGAIEKSFRVRVQAPPNIVGPRG 2305
Query: 400 VQYAVRGDGGK--VECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLT 457
++ V G+ +EC + + P P +I W L+ ++ LST
Sbjct: 2306 PRFVVGLAPGQLVLECSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALSTAD 2364
Query: 458 INNVMEADFQTHYNCTAWNSFGPGTAIIQLE 488
+ Y+CTA N+ G + ++E
Sbjct: 2365 SGD---------YSCTARNAAGSTSVAFRVE 2386
Score = 72.0 bits (175), Expect = 2e-12
Identities = 122/492 (24%), Positives = 193/492 (39%), Gaps = 56/492 (11%)
Query: 28 ADQTVVAGQRAVLPCVLLNYS-GIVQWTKDGLALGMGQGLKA------WPRYRVVGSADA 80
A+ + +AGQ L C + + W KD +G+ G W + D
Sbjct: 26 ANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDE 85
Query: 81 GQYNLEITDAELSDDASYECQA-TEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPH 139
GQ +L + D Y C+A +A R L VL PP +L AG
Sbjct: 86 GQ-SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADV 144
Query: 140 NLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDL-DIGRVF 198
L C + P + W +D ++ +DG+ L I + + D GR +
Sbjct: 145 ELQCWT-SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ------VLRITGSHVGDEGR-Y 196
Query: 199 TCRSMNEAIPSGKET-SIELDVHHPPTVTLSIEPQ--TVQEGERVVFTCQATANPEILGY 255
C + + P+G++ +L VH PPT+ S E V E V C+A P
Sbjct: 197 QCVAFS---PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTP-NI 252
Query: 256 RWAKGGFLIEDAHESRY-------ETNVDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAP 308
W K G L+ + + Y + S +C+ N VG+ +T ++V+ P
Sbjct: 253 TWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP 312
Query: 309 RIVVD---PKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQ-------LLL 358
I P G V L CV G+P TL+W + + SN ++ L L
Sbjct: 313 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRL 372
Query: 359 KSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPP-IISSEAVQY--AVRGDGGKVECFI 415
+S +A +G Y+C A P G A + + V PP ++ +E + + G ++ C
Sbjct: 373 ESPGEASSGLYSCVASSP-AGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA 431
Query: 416 GSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAW 475
+P P I W E E V+ + G +TL I++V E D + C A
Sbjct: 432 SGSPVP-TIQWLQNGRPAE----ELAGVQVASQG----TTLHIDHV-ELDHSGLFACQAT 481
Query: 476 NSFGPGTAIIQL 487
N G A +++
Sbjct: 482 NEAGTAGAEVEV 493
Score = 70.1 bits (170), Expect = 7e-12
Identities = 120/525 (22%), Positives = 200/525 (38%), Gaps = 105/525 (20%)
Query: 24 SQEPADQ--TVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
+++ AD+ TV L C L + S + W KDG + ++ P
Sbjct: 1261 AEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP---------- 1310
Query: 81 GQYNLEITDAELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTRID-----GGPVILLQ 134
G + L+I +A+ D Y C T E + + VLIPP ++ D G + +
Sbjct: 1311 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTK 1370
Query: 135 AGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDI 194
+ L C ++ A P TI W++DG Q + ++L +G+ L I PT +
Sbjct: 1371 VNSTLTLECESW-AVPPPTIRWYKDG-QPVTPSSRLQVLGEGRL------LQIQPTQVSD 1422
Query: 195 GRVFTCRSMNEAIPSGKETSIELDVHHPPTVT-----------LSIEPQT---------V 234
+ C + N A ++ ++ + V PP LS E + +
Sbjct: 1423 SGRYLCVATNVAGEDDQDFNVLIQV--PPMFQKVGDFSAAFEILSREEEARGGVTEYREI 1480
Query: 235 QEGERVVFTCQATA--NPEILGYRW------------AKGGF-----LIEDAHESRYETN 275
E C A P++ YR +GG L+ + RY
Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRY--- 1537
Query: 276 VDYSFFTEPVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKP----TTTDIGSDVTLTCVW 331
SC+ N+VG + + V P I+ D + T + S V+L C
Sbjct: 1538 ----------SCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPA 1587
Query: 332 VGNPPLTLTW-------TKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE 384
+GNP T++W + VL + L + + ADA +Y C A + G AE+
Sbjct: 1588 LGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVA-ENQAGSAEKL 1646
Query: 385 VPLYVNGPPIISSEAVQY--AVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYT 442
L V PP I+ ++ A+ + C + + P P+ + W L +G E +
Sbjct: 1647 FTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPE-VTWYKDSQALSLGE-EVFL 1704
Query: 443 VERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
+ T+ TL + +D Y C A N+ G ++QL
Sbjct: 1705 LPGTH-------TLQLGRARLSD-SGMYTCEALNAAGRDQKLVQL 1741
Score = 68.2 bits (165), Expect = 3e-11
Identities = 100/366 (27%), Positives = 143/366 (39%), Gaps = 43/366 (11%)
Query: 85 LEITDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPV---ILLQAGTPHN 140
L+I +L D+ Y C AT A S+R L VL+PP I+ GPV +L A
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPN---IEPGPVNKAVLENASV--T 622
Query: 141 LTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTC 200
L C A + P + WF+ G Q + + DG+ L I L + C
Sbjct: 623 LECLA-SGVPPPDVSWFK-GHQPVSSWMGVTVSVDGR------VLRIEQAQLSDAGSYRC 674
Query: 201 RSMNEAIPSGKETSIELDVHHPPTVTLSIE-PQTVQEGERVVFTCQATANPEILGYRWAK 259
+ N A E L V+ PP +TL P V V TC AT P W K
Sbjct: 675 VASNVA--GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT-LMWLK 731
Query: 260 GGFLIEDAHESRYETNVDYSFFTEP---------VSCEVHNKVGSTNVSTLVNVHFAPRI 310
G + A + T SC + VG ++ VH P I
Sbjct: 732 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 791
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-----VLSNSNQLLLKSVTQA- 364
+ + + V L C PP L+W K + V ++++ LL+ V +A
Sbjct: 792 LGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQ-VDRAD 850
Query: 365 --DAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS-SEAVQYAVR-GDGGKVECFIGSTPP 420
DAG YTC A+ + G +E+ L V P+ E+ VR G ++ C P
Sbjct: 851 VWDAGHYTCEAL-NQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPF 909
Query: 421 PDRIAW 426
P +I+W
Sbjct: 910 P-KISW 914
Score = 65.9 bits (159), Expect = 1e-10
Identities = 92/381 (24%), Positives = 140/381 (36%), Gaps = 43/381 (11%)
Query: 29 DQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEI 87
D + G A LPC + W KDG + +G ++ + S + NLE
Sbjct: 2764 DLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEG-----KFTIQPSGELLVKNLEG 2818
Query: 88 TDAELSDDASYECQATEAALRSRR-AKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAF 146
DA +Y C A A R+RR LT+L+ P T + G + L G L C A
Sbjct: 2819 QDA-----GTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRL--GDRLWLRCAA- 2870
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
P I W T + V +DG +T+ + ++ D + C + N
Sbjct: 2871 RGSPTPRIGW----TVNDRPVTEGVSEQDGG--STLQRAAVSRED---SGTYVCWAENRV 2921
Query: 207 IPSGKETSIE-LDVHHPPTVTLSIEPQTVQE-GERVVFTCQATANPEILGYRWAKGGFLI 264
G+ ++ + V P + V+ G + C +P + W K G +
Sbjct: 2922 ---GRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDP-VPDIHWIKDGLPL 2977
Query: 265 EDAHESRYETNVDYSFFTEP------VSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTT 318
+H N + C N++G ++ + AP V+P+ T
Sbjct: 2978 RGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMT 3037
Query: 319 TDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSN------SNQLLLKSVTQADAGTYTCR 372
G DV L C G P T+ W + + S L L++V DAGTY C
Sbjct: 3038 VRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCV 3097
Query: 373 AIVPRIGVAEREVPLYVNGPP 393
A +G A L V G P
Sbjct: 3098 A-HNLLGSATARAFLVVRGEP 3117
Score = 64.7 bits (156), Expect = 3e-10
Identities = 96/371 (25%), Positives = 148/371 (39%), Gaps = 51/371 (13%)
Query: 48 SGIVQWTKDGLALGMG--QGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEA 105
S + W KDG + GL+ +P RV L + A SD Y C A A
Sbjct: 724 SPTLMWLKDGNPVSPAGTPGLQVFPGGRV----------LTLASARASDSGRYSCVAVSA 773
Query: 106 ALRSRR-AKLTVLIPPEDTRIDGGPV-ILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQ 163
R+ L V +PP I G + + + A L C++ +A P + W++DG
Sbjct: 774 VGEDRQDVVLQVHMPPS---ILGEELNVSVVANESVALECQS-HAMPPPVLSWWKDGRPL 829
Query: 164 EGAVASTELLKDGKRETTVSQLL-INPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHP 222
E + G + LL ++ D+ +TC ++N+A S K ++ + V P
Sbjct: 830 EP--------RPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA-P 880
Query: 223 PTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGF-LIEDAHESRYETNVDYSFF 281
TV+EG +C+ P W K G L + ++ + V +
Sbjct: 881 VFPLRESHTLTVREGHPTRLSCECRGVP-FPKISWRKDGQPLPGEGAGLQHVSAVGRLLY 939
Query: 282 TEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVVDPK--PTTTDIGSD--VTLTC 329
+CE N VG+++ + VH P+I P+ PT + D TL C
Sbjct: 940 LGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQI-AGPREPPTQVSVVQDGVATLEC 998
Query: 330 VWVGNPPLTLTWTK------KDSNMVLSNSNQLL-LKSVTQADAGTYTCRAIVPRIGVAE 382
G PP T+TW + + + L N Q L ++ A G Y+C A G AE
Sbjct: 999 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA-ENLAGRAE 1057
Query: 383 REVPLYVNGPP 393
R+ L V PP
Sbjct: 1058 RKFELSVLVPP 1068
Score = 61.6 bits (148), Expect = 3e-09
Identities = 103/449 (22%), Positives = 161/449 (35%), Gaps = 72/449 (16%)
Query: 80 AGQYNLEITDAELSDDASYECQATEAALRSRRA-KLTVLIPPEDTRIDGGPVILLQAGTP 138
AG + L++T + D Y C A+ A +RR + VL+PP D VI + G
Sbjct: 1121 AGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQT 1180
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
+L C P + WF+DG A + DG L + +L +
Sbjct: 1181 AHLMCNV-TGHPQPKLTWFKDGRPLARGDAH-HISPDGVL------LQVLQANLSSAGHY 1232
Query: 199 TCRSMNEAIPSGKETS-IELDVHHPPTVTLSIEPQ-----TVQEGERVVFTCQATANPEI 252
+C + N G++T +L V PT+ E TV + C+A A P
Sbjct: 1233 SCIAANAV---GEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSP 1289
Query: 253 LGYRWAKGGFLIEDAHESRYETNV-----------DYSFFTEPVSCEVHNKVGSTNVSTL 301
W K G E + + D +T V+ E+ V + +V L
Sbjct: 1290 -NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVL 1348
Query: 302 VNVHFA---PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTW-------TKKDSNMVLS 351
+ + P V K T + S +TL C PP T+ W T VL
Sbjct: 1349 IPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLG 1408
Query: 352 NSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISS--------EAVQYA 403
L ++ +D+G Y C A G +++ + + PP+ E +
Sbjct: 1409 EGRLLQIQPTQVSDSGRYLCVA-TNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSRE 1467
Query: 404 VRGDGGKVE-------------CFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGS 450
GG E C + PPPD + W ++ L G + +V + G
Sbjct: 1468 EEARGGVTEYREIVENNPAYLYCDTNAIPPPD-LTWYREDQPLSAG--DEVSVLQ---GG 1521
Query: 451 GVLSTLTINNVMEADFQTHYNCTAWNSFG 479
VL ++ A+ Y+C A N G
Sbjct: 1522 RVLQI----PLVRAENAGRYSCKASNEVG 1546
Score = 60.5 bits (145), Expect = 6e-09
Identities = 90/398 (22%), Positives = 143/398 (35%), Gaps = 60/398 (15%)
Query: 33 VAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAE 91
VAG+ L CV + S + W +GL + R GS L +
Sbjct: 327 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNE----SRLETDGSV------LRLESPG 376
Query: 92 LSDDASYECQATEAALRS-RRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKP 150
+ Y C A+ A + + + V +PP+ +G + G P L C+A + P
Sbjct: 377 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSP 435
Query: 151 AATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSG 210
TI W ++G E +A ++ G + L I+ +LD +F C++ NEA +G
Sbjct: 436 VPTIQWLQNGRPAE-ELAGVQVASQG------TTLHIDHVELDHSGLFACQATNEAGTAG 488
Query: 211 KETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEI-----------LGYRWAK 259
E + + P V L + G + A +P + L W
Sbjct: 489 AEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCS 547
Query: 260 GGFLIEDAHESRYETNVDYSFFTEP--------------VSCEVHNKVGSTNVSTLVNVH 305
G L + T + ++ P +C N G + + V
Sbjct: 548 PGSLWGE------PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL 601
Query: 306 FAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNM-------VLSNSNQLLL 358
P I P + VTL C+ G PP ++W K + V + L +
Sbjct: 602 VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRI 661
Query: 359 KSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS 396
+ +DAG+Y C A G E L VN PP I+
Sbjct: 662 EQAQLSDAGSYRCVA-SNVAGSTELRYGLRVNVPPRIT 698
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 90.9 bits (224), Expect = 4e-18
Identities = 104/431 (24%), Positives = 170/431 (39%), Gaps = 42/431 (9%)
Query: 79 DAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
++G + EI A +++ +YEC A A + RAK +++ ++ P + + G
Sbjct: 358 ESGNSSWEILRASKAEEGTYECTAVSRA-GTGRAKAQIVVTDPPPQLVPAPNVTVSPGET 416
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
L+CR P + W RD + L D E + I PTD G +
Sbjct: 417 AVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVAQLADLSLEISG----IIPTD---GGRY 468
Query: 199 TCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
C + N S+ L V P V++ Q +G V +C A+ P W+
Sbjct: 469 QCVASN--ANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYP-TPHISWS 525
Query: 259 KGGFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRI 310
+ +++ +SR + + + V SC+ N+VG+ + + P +
Sbjct: 526 RESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 583
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL----SNSNQLLLKSVTQADA 366
+G + L C G PP + W + M+L S+S +L + + + DA
Sbjct: 584 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDA 643
Query: 367 GTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR-GDGGKVECFIGSTPPPDRIA 425
GTYTCRA V +G A E+ L V P ++ V G + C PPP +
Sbjct: 644 GTYTCRA-VNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPP-TVT 701
Query: 426 WAWKEN---FLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGT 482
W + L +G + +SG L +V D Q Y C A N FG
Sbjct: 702 WRRGDGQPLGLRLGAGRGSRSRQPDSG-----VLFFESVAPED-QAPYVCEARNVFGK-- 753
Query: 483 AIIQLEEREVL 493
+Q E R ++
Sbjct: 754 --VQAEARLIV 762
Score = 86.7 bits (213), Expect = 7e-17
Identities = 116/476 (24%), Positives = 174/476 (36%), Gaps = 61/476 (12%)
Query: 32 VVAGQRAVLPCVLLNYSGI----VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEI 87
V G+ AVL C SG+ V W + GL + ++ + L I
Sbjct: 592 VAVGEEAVLVC---EASGVPPPRVIWYRGGLEM-------------ILAPEGSSSGKLRI 635
Query: 88 TDAELSDDASYECQAT-EAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAF 146
A+ D +Y C+A E S +L V P+ T + + ++ G L CRA
Sbjct: 636 PAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRD--VTVELGRSALLACRA- 692
Query: 147 NAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSMNEA 206
+P T+ W R Q G R+ L + + C + N
Sbjct: 693 TGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
Query: 207 IPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIED 266
E + + H PP + S V EG+ V C A + W K G +
Sbjct: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 811
Query: 267 AHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTT 318
SR+ D S + SC N GS + + V PRI
Sbjct: 812 G--SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI 869
Query: 319 TDIGSDVTLTCVWVGNPPLTLTWTKKDSNMV-------LSNSNQLLLKSVTQADAGTYTC 371
T+ G +L CV G P T+TWTK+ + + +S LL+ + DAG Y C
Sbjct: 870 TNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 929
Query: 372 RAIVPRIGVAEREVPLYVNGPPIISSEAVQ--------YAVRGDGGKVECFIGSTPPPDR 423
A +G + +E+ L VN P I + A G+ ++C +PPP
Sbjct: 930 TA-TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPP-L 987
Query: 424 IAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
+ W K++ RY + SGS L+ + + + HY CTA N G
Sbjct: 988 VTWT-KDSRPVPPITNRYGL--LPSGSLRLAQVQVGD------SGHYECTASNPAG 1034
Score = 78.6 bits (192), Expect = 2e-14
Identities = 111/475 (23%), Positives = 185/475 (38%), Gaps = 65/475 (13%)
Query: 31 TVVAGQRAVLPCVLLNYSGI-VQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITD 89
TV G+ AVL C +L + + W +D L G RV AD +LEI+
Sbjct: 410 TVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTG-------RVAQLADL---SLEISG 459
Query: 90 AELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAK 149
+D Y+C A+ A +R + ++ I Q G ++C A +
Sbjct: 460 IIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSA-SGY 517
Query: 150 PAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQ--LLINPTDLDIGRVFTCRSMNEAI 207
P I W R+ ++ L++ R +Q L+I + ++C++ NE +
Sbjct: 518 PTPHISWSRE----------SQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNE-V 566
Query: 208 PSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATA--NPEILGYRWAKGGFLIE 265
+ +ET + L PP+V+ V GE V C+A+ P ++ W +GG +
Sbjct: 567 GTDQET-VTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVI---WYRGGLEMI 622
Query: 266 DAHESRYETNVDYSFFTE----PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDI 321
A E + E +C N++G + + V AP++ P+ T ++
Sbjct: 623 LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVEL 682
Query: 322 GSDVTLTCVWVGNPPLTLTWTKKD-------------SNMVLSNSNQLLLKSVTQADAGT 368
G L C G PP T+TW + D S +S L +SV D
Sbjct: 683 GRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP 742
Query: 369 YTCRAIVPRIGVAEREVPLYVNG---PPIISSEAVQYAVRGDGGKVECFI-GSTPPPDRI 424
Y C A G + E L V G P I SS + G + C + P P+R
Sbjct: 743 YVCEA-RNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPER- 800
Query: 425 AWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFG 479
W ++ + R+++ S L ++ ++ + Y+C A N+ G
Sbjct: 801 --HWLKDGRPLPPGSRHSIRADGS-------LHLDRALQ-EHAGRYSCVATNTAG 845
Score = 71.6 bits (174), Expect = 2e-12
Identities = 100/395 (25%), Positives = 142/395 (35%), Gaps = 46/395 (11%)
Query: 18 GTQTRFSQEPADQTVVAGQRAVLPCVLLNYSG-IVQWTK-DGLALGMGQGLKAWPRYRVV 75
G + ++ P D TV G+ A+L C V W + DG LG+ G R R
Sbjct: 666 GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR-- 723
Query: 76 GSADAGQYNLEITDAELSDDASYECQATEA---ALRSRRAKLTVLIPPEDTRIDGGPVIL 132
D+G E E D A Y C+A R +T PP+ P +
Sbjct: 724 -QPDSGVLFFESVAPE--DQAPYVCEARNVFGKVQAEARLIVTGHAPPQIA--SSAPTVR 778
Query: 133 LQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDL 192
+ G P +L C +P W +DG + + DG S L
Sbjct: 779 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPG-SRHSIRADG------SLHLDRALQE 831
Query: 193 DIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEI 252
GR ++C + N A + +EL V PP + + EG C A+ P
Sbjct: 832 HAGR-YSCVATNTA--GSQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAP 888
Query: 253 LGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVS-------CEVHNKVGSTNVSTLVNVH 305
W K + + +P + C N VG ++ ++V+
Sbjct: 889 T-ITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVN 947
Query: 306 FAPRIVVD-------PKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMV--------L 350
PRI ++ P T G +VTL C G+PP +TWTK DS V L
Sbjct: 948 TKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK-DSRPVPPITNRYGL 1006
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREV 385
S L L V D+G Y C A P + R V
Sbjct: 1007 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYV 1041
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/235 (22%), Positives = 82/235 (34%), Gaps = 23/235 (9%)
Query: 287 CEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDS 346
C ++ G+ + V P +V T G L+C +G P LTW +
Sbjct: 379 CTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR 438
Query: 347 NMVLSNSN-------QLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIIS-SE 398
+ S L + + D G Y C A GV V L V P +S
Sbjct: 439 VLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN-GVTRASVWLLVREAPQVSIHT 497
Query: 399 AVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTI 458
+ Q+ +G KV C P P I+W+ + L+ E + TL I
Sbjct: 498 SSQHFSQGVEVKVSCSASGYPTP-HISWSRESQALQ---------EDSRIHVDAQGTLII 547
Query: 459 NNVMEADFQTHYNCTAWNSFGPGTAIIQL---EEREVLPVGIIAGATIGASILLI 510
V D +Y+C A N G + L + V V + +G +L+
Sbjct: 548 QGVAPED-AGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLV 601
>gi|71274107 melanoma cell adhesion molecule [Homo sapiens]
Length = 646
Score = 87.0 bits (214), Expect = 6e-17
Identities = 143/600 (23%), Positives = 229/600 (38%), Gaps = 98/600 (16%)
Query: 24 SQEPADQTVVA--GQRAVLPCVLLNYSGI---VQWT---KDGLAL----GMGQGLKAWPR 71
+++PA + V G A+L C L G V W K+ L GQG
Sbjct: 28 AEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGE 87
Query: 72 YRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPV- 130
Y S L +T D+ + CQ + R +L V PE+ I P+
Sbjct: 88 YEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLG 147
Query: 131 ILLQAGTPHNL-TCRAFNAKPAATIIWFRDGT-----QQEGAVASTELLKDGKRETTVSQ 184
I + + P + TC N P +IW+++G + + S++ ++ T S
Sbjct: 148 IPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSI 207
Query: 185 LLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHP---PT--VTLSIEPQ-TVQEGE 238
L D F C +N +PSG +V P PT V L +EP ++EG+
Sbjct: 208 LKAQLVKEDKDAQFYCE-LNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGD 266
Query: 239 RVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVHNKVG--ST 296
RV C A NP + +K +A E TN + EP E +
Sbjct: 267 RVEIRCLADGNPPP-HFSISKQNPSTREAEEET--TNDNGVLVLEPARKEHSGRYECQGL 323
Query: 297 NVSTLVN---------VHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSN 347
++ T+++ V++ + V P GS +TLTC + L W ++++
Sbjct: 324 DLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETG 383
Query: 348 MVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAERE--VPLYVNGPPIISSEAVQYAVR 405
VL L L + + G Y C A VP I R V + + GPP ++ + + V+
Sbjct: 384 QVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVK 443
Query: 406 GDGG-KVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEA 464
+ + C P P +W N GT E+ VLSTL + E
Sbjct: 444 ENMVLNLSCEASGHPRP---TISWNVN----GTAS----EQDQDPQRVLSTLNVLVTPEL 492
Query: 465 DFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAS------------------ 506
+T CTA N G T+I+ LE + + + T G S
Sbjct: 493 -LETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERK 551
Query: 507 -----------------ILLIFFFIALVFFLYRR-----RKGSRKDVTL---RKLDIKVE 541
IL++ A+++FLY++ R+ ++++TL RK ++ VE
Sbjct: 552 LPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVE 611
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/438 (23%), Positives = 160/438 (36%), Gaps = 51/438 (11%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ A L C + ++W K G + K PR +
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD---KDDPRSHRMLLPSG 86
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ Y C A S A L V I +D R + V ++ G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-MVAVG 145
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P + C+ P TI W +DG+ + KD + +L+I T
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDD--------KDERITIRGGKLMITYTRKSDAG 197
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+ C N E + EL V P+ V + F C+A +P + R
Sbjct: 198 KYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVR 255
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFAP 308
W K + +SRYE D++ V+ C N VG S + V P
Sbjct: 256 WRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
Query: 309 RIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------SNSN 354
VV P+ +G VT C GNP + W ++ S +L S +
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 355 QLLLKSVTQADAGTYTCR------AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDG 408
L + +V ++D G Y C+ +I+ + + +V + PP+I V V DG
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV-IADRPPPVIRQGPVNQTVAVDG 431
Query: 409 GKVECFIGSTPPPDRIAW 426
V + + P I W
Sbjct: 432 TFVLSCVATGSPVPTILW 449
Score = 65.1 bits (157), Expect = 2e-10
Identities = 96/386 (24%), Positives = 134/386 (34%), Gaps = 59/386 (15%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
F Q P+D V G+ AV+ C + + W KDG L R + G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGG--- 184
Query: 81 GQYNLEITDAELSDDASYECQATEAA--LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
L IT SD Y C T S A+LTVL P + + +
Sbjct: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
R P T+ W +D EL K L I +
Sbjct: 242 FKCEARG---DPVPTVRWRKD---------DGELPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 199 TCRSMNEAIPSGK-ETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
TC + N GK E S L V PP + Q V G V F C+AT NP+ +
Sbjct: 290 TCVAENMV---GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 346
Query: 258 AKGGFLIEDAHE-----SRYE---------TNVDYSFFTEPVSCEVHNKVGST------N 297
+G + +++ SR+ TNV S + C+ N GS
Sbjct: 347 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI-CQTLNVAGSIITKAYLE 405
Query: 298 VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVL 350
V+ ++ P I P T + L+CV G+P T+ W K +DS +
Sbjct: 406 VTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ 465
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVP 376
+ L ++ D G YTC A P
Sbjct: 466 LENGVLQIRYAKLGDTGRYTCIASTP 491
Score = 34.7 bits (78), Expect = 0.34
Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 16/91 (17%)
Query: 299 STLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------------KDS 346
S L F PRIV P G TL C G P T+ W K +
Sbjct: 20 SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 79
Query: 347 NMVLSNSNQLLLKSV----TQADAGTYTCRA 373
M+L + + L+ V ++ D G Y C A
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVA 110
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/438 (23%), Positives = 160/438 (36%), Gaps = 51/438 (11%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ A L C + ++W K G + K PR +
Sbjct: 69 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD---KDDPRSHRMLLPSG 125
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ Y C A S A L V I +D R + V ++ G
Sbjct: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-MVAVG 184
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P + C+ P TI W +DG+ + KD + +L+I T
Sbjct: 185 EPAVMECQPPRGHPEPTISWKKDGSPLDD--------KDERITIRGGKLMITYTRKSDAG 236
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+ C N E + EL V P+ V + F C+A +P + R
Sbjct: 237 KYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVR 294
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFAP 308
W K + +SRYE D++ V+ C N VG S + V P
Sbjct: 295 WRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Query: 309 RIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------SNSN 354
VV P+ +G VT C GNP + W ++ S +L S +
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 355 QLLLKSVTQADAGTYTCR------AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVRGDG 408
L + +V ++D G Y C+ +I+ + + +V + PP+I V V DG
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV-IADRPPPVIRQGPVNQTVAVDG 470
Query: 409 GKVECFIGSTPPPDRIAW 426
V + + P I W
Sbjct: 471 TFVLSCVATGSPVPTILW 488
Score = 65.1 bits (157), Expect = 2e-10
Identities = 96/386 (24%), Positives = 134/386 (34%), Gaps = 59/386 (15%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
F Q P+D V G+ AV+ C + + W KDG L R + G
Sbjct: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGG--- 223
Query: 81 GQYNLEITDAELSDDASYECQATEAA--LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
L IT SD Y C T S A+LTVL P + + +
Sbjct: 224 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 280
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
R P T+ W +D EL K L I +
Sbjct: 281 FKCEARG---DPVPTVRWRKD---------DGELPKSRYEIRDDHTLKIRKVTAGDMGSY 328
Query: 199 TCRSMNEAIPSGK-ETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
TC + N GK E S L V PP + Q V G V F C+AT NP+ +
Sbjct: 329 TCVAENMV---GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 385
Query: 258 AKGGFLIEDAHE-----SRYE---------TNVDYSFFTEPVSCEVHNKVGST------N 297
+G + +++ SR+ TNV S + C+ N GS
Sbjct: 386 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI-CQTLNVAGSIITKAYLE 444
Query: 298 VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVL 350
V+ ++ P I P T + L+CV G+P T+ W K +DS +
Sbjct: 445 VTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ 504
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVP 376
+ L ++ D G YTC A P
Sbjct: 505 LENGVLQIRYAKLGDTGRYTCIASTP 530
Score = 37.7 bits (86), Expect = 0.040
Identities = 31/106 (29%), Positives = 40/106 (37%), Gaps = 17/106 (16%)
Query: 284 PVSCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK 343
P S N +G T S L F PRIV P G TL C G P T+ W K
Sbjct: 45 PTSDNDDNSLGYTG-SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 103
Query: 344 ------------KDSNMVLSNSNQLLLKSV----TQADAGTYTCRA 373
+ M+L + + L+ V ++ D G Y C A
Sbjct: 104 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVA 149
>gi|187608363 cell adhesion molecule 3 isoform 2 [Homo sapiens]
Length = 398
Score = 84.3 bits (207), Expect = 4e-16
Identities = 69/268 (25%), Positives = 124/268 (46%), Gaps = 12/268 (4%)
Query: 3 SLLVWILTLSDTFSQG----TQTRFSQEPADQTVVAGQRAVLPCVLLNYS-GIVQWTKDG 57
SLL+ +L + ++ G +Q +D+TVVAG VL C + ++ +QW+
Sbjct: 7 SLLLLLLLFACCWAPGGANLSQDDSQPWTSDETVVAGGTVVLKCQVKDHEDSSLQWSNPA 66
Query: 58 ---LALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKL 114
L G + L+ R ++V S + ++ I++ L+D+ Y C +R+ ++ +
Sbjct: 67 QQTLYFGEKRALRD-NRIQLVTSTPH-ELSISISNVALADEGEYTCSIFTMPVRTAKSLV 124
Query: 115 TVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLK 174
TVL P+ I G L + T L C++ +KPAA + W + + G +
Sbjct: 125 TVLGIPQKPIITGYKSSLREKDTA-TLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDP 183
Query: 175 DGKRETTVSQLLINPTDLDIGRVFTCRSMNEAIPSG-KETSIELDVHHPPTVTLSIEPQT 233
+GK T S + T D G C +E++ + TS ++V + PT + +P
Sbjct: 184 NGKTFTVSSSVTFQVTREDDGASIVCSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPH 243
Query: 234 VQEGERVVFTCQATANPEILGYRWAKGG 261
+EG++++ C+ NP Y W K G
Sbjct: 244 PREGQKLLLHCEGRGNPVPQQYLWEKEG 271
Score = 54.3 bits (129), Expect = 4e-07
Identities = 66/307 (21%), Positives = 124/307 (40%), Gaps = 30/307 (9%)
Query: 121 EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET 180
++T + GG V+L H + ++ PA ++F G ++ +L+ E
Sbjct: 37 DETVVAGGTVVLKCQVKDHEDSSLQWS-NPAQQTLYF--GEKRALRDNRIQLVTSTPHEL 93
Query: 181 TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV 240
++S + N D G +TC + + K L + P +T +++E +
Sbjct: 94 SIS--ISNVALADEGE-YTCSIFTMPVRTAKSLVTVLGIPQKPIITGY--KSSLREKDTA 148
Query: 241 VFTCQATANPEILGYRWAKGGFLI--------EDAHESRYETNVDYSFFTE------PVS 286
CQ++ + W KG + ED + + + +F +
Sbjct: 149 TLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIV 208
Query: 287 CEVHN---KVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNP-PLTLTWT 342
C V++ K + S + V + P ++ P P G + L C GNP P W
Sbjct: 209 CSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWE 268
Query: 343 KKDS--NMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP-PIISSEA 399
K+ S + ++ + L+ + ++D+GTY C A +G + L VN P P+ SS +
Sbjct: 269 KEGSVPPLKMTQESALIFPFLNKSDSGTYGCTA-TSNMGSYKAYYTLNVNDPSPVPSSSS 327
Query: 400 VQYAVRG 406
+A+ G
Sbjct: 328 TYHAIIG 334
>gi|11056046 cell adhesion molecule 3 isoform 1 [Homo sapiens]
Length = 432
Score = 84.0 bits (206), Expect = 5e-16
Identities = 63/239 (26%), Positives = 112/239 (46%), Gaps = 8/239 (3%)
Query: 28 ADQTVVAGQRAVLPCVLLNYS-GIVQWTKDG---LALGMGQGLKAWPRYRVVGSADAGQY 83
+D+TVVAG VL C + ++ +QW+ L G + L+ R ++V S +
Sbjct: 70 SDETVVAGGTVVLKCQVKDHEDSSLQWSNPAQQTLYFGEKRALRD-NRIQLVTSTPH-EL 127
Query: 84 NLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTC 143
++ I++ L+D+ Y C +R+ ++ +TVL P+ I G L + T L C
Sbjct: 128 SISISNVALADEGEYTCSIFTMPVRTAKSLVTVLGIPQKPIITGYKSSLREKDTA-TLNC 186
Query: 144 RAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVFTCRSM 203
++ +KPAA + W + + G + +GK T S + T D G C
Sbjct: 187 QSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIVCSVN 246
Query: 204 NEAIPSG-KETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGG 261
+E++ + TS ++V + PT + +P +EG++++ C+ NP Y W K G
Sbjct: 247 HESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWEKEG 305
Score = 54.3 bits (129), Expect = 4e-07
Identities = 66/307 (21%), Positives = 124/307 (40%), Gaps = 30/307 (9%)
Query: 121 EDTRIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRET 180
++T + GG V+L H + ++ PA ++F G ++ +L+ E
Sbjct: 71 DETVVAGGTVVLKCQVKDHEDSSLQWS-NPAQQTLYF--GEKRALRDNRIQLVTSTPHEL 127
Query: 181 TVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERV 240
++S + N D G +TC + + K L + P +T +++E +
Sbjct: 128 SIS--ISNVALADEGE-YTCSIFTMPVRTAKSLVTVLGIPQKPIITGY--KSSLREKDTA 182
Query: 241 VFTCQATANPEILGYRWAKGGFLI--------EDAHESRYETNVDYSFFTE------PVS 286
CQ++ + W KG + ED + + + +F +
Sbjct: 183 TLNCQSSGSKPAARLTWRKGDQELHGEPTRIQEDPNGKTFTVSSSVTFQVTREDDGASIV 242
Query: 287 CEVHN---KVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNP-PLTLTWT 342
C V++ K + S + V + P ++ P P G + L C GNP P W
Sbjct: 243 CSVNHESLKGADRSTSQRIEVLYTPTAMIRPDPPHPREGQKLLLHCEGRGNPVPQQYLWE 302
Query: 343 KKDS--NMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGP-PIISSEA 399
K+ S + ++ + L+ + ++D+GTY C A +G + L VN P P+ SS +
Sbjct: 303 KEGSVPPLKMTQESALIFPFLNKSDSGTYGCTA-TSNMGSYKAYYTLNVNDPSPVPSSSS 361
Query: 400 VQYAVRG 406
+A+ G
Sbjct: 362 TYHAIIG 368
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 83.6 bits (205), Expect = 6e-16
Identities = 79/323 (24%), Positives = 133/323 (41%), Gaps = 27/323 (8%)
Query: 79 DAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
++G + EI A +++ +YEC A A + RAK +++ ++ P + + G
Sbjct: 474 ESGNSSWEILRASKAEEGTYECTAVSRA-GTGRAKAQIVVTDPPPQLVPAPNVTVSPGET 532
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
L+CR P + W RD + L D E + I PTD G +
Sbjct: 533 AVLSCRVLGEAPY-NLTWVRDWRVLPASTGRVAQLADLSLEISG----IIPTD---GGRY 584
Query: 199 TCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWA 258
C + N S+ L V P V++ Q +G V +C A+ P W+
Sbjct: 585 QCVASNAN--GVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP-HISWS 641
Query: 259 KGGFLIEDAHESRYETNVDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRI 310
+ +++ +SR + + + V SC+ N+VG+ + + P +
Sbjct: 642 RESQALQE--DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV 699
Query: 311 VVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL----SNSNQLLLKSVTQADA 366
+G + L C G PP + W + M+L S+S +L + + + DA
Sbjct: 700 SAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDA 759
Query: 367 GTYTCRAIVPRIGVAEREVPLYV 389
GTYTCRA V +G A E+ L V
Sbjct: 760 GTYTCRA-VNELGDASAEIQLAV 781
Score = 71.2 bits (173), Expect = 3e-12
Identities = 74/288 (25%), Positives = 112/288 (38%), Gaps = 33/288 (11%)
Query: 216 ELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGGFLIEDAHESRYETN 275
++ V PP + TV GE V +C+ W + + + A R
Sbjct: 509 QIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPY-NLTWVRD-WRVLPASTGRVAQL 566
Query: 276 VDYSFFTEPV--------SCEVHNKVGSTNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTL 327
D S + C N G T S + V AP++ + G +V +
Sbjct: 567 ADLSLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKV 626
Query: 328 TCVWVGNPPLTLTWTKK------DSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVA 381
+C G P ++W+++ DS + + L+++ V DAG Y+C+A +G
Sbjct: 627 SCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQA-TNEVGTD 685
Query: 382 EREVPLYVNGPPIISS-EAVQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLER 440
+ V LY PP +S+ AV G+ + C PPP R+ W G LE
Sbjct: 686 QETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPP-RVIWYR-------GGLEM 737
Query: 441 YTV-ERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQL 487
E ++SG L I E D T Y C A N G +A IQL
Sbjct: 738 ILAPEGSSSGK-----LRIPAAQERDAGT-YTCRAVNELGDASAEIQL 779
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 82.4 bits (202), Expect = 1e-15
Identities = 124/504 (24%), Positives = 191/504 (37%), Gaps = 63/504 (12%)
Query: 23 FSQEPADQTVVAGQRAVL--PCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVV----G 76
F + Q+V G+ AV+ P + V W +DG + + +V
Sbjct: 115 FEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTV 174
Query: 77 SADAGQYNLE-ITDAELSDDASYECQATEAALRSRRAKL--TVLIPPEDTRIDGGPVILL 133
+ DAG+Y ++ + D + S T + + T++IPP++T + G
Sbjct: 175 APDAGRYYVQAVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT---- 230
Query: 134 QAGTPHNLTCRAFNAKPAAT--IIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTD 191
+ L C A NA+P IIW +DG G ++ D R T+ NPT
Sbjct: 231 ---SEVTLECVA-NARPLIKLHIIWKKDGVLLSGGIS------DHNRRLTIP----NPTG 276
Query: 192 LDIGRVFTCRSM--NEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVV-FTCQATA 248
D G + C ++ + ++PS + L V PP E E E+VV CQA
Sbjct: 277 SDAG-YYECEAVLRSSSVPSVVRGAY-LSVLEPPQFVKEPERHITAEMEKVVDIPCQAKG 334
Query: 249 NPEILGYRWAKGGFLIEDAHESRYETNVDYSFF--------TEPVSCEVHNKVGSTNVST 300
P W K ++E +R+ D T C N G ST
Sbjct: 335 VPPP-SITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTST 393
Query: 301 LVNV-HFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSN------- 352
+ V AP I P +T G V L C G P +TW K + + +
Sbjct: 394 YLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFT 453
Query: 353 ---SNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAV-QYAVRGDG 408
S LL+ +DAGTYTC A R GV E L V I+ Q ++G
Sbjct: 454 PLESGSLLISPTHISDAGTYTCLATNSR-GVDEASADLVVWARTRITKPPQDQSVIKGTQ 512
Query: 409 GKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQT 468
+ C + + P I + W+++ +GT + +GS L I+ D T
Sbjct: 513 ASMVCGV-THDPRVTIRYIWEKDGATLGTESHPRIRLDRNGS-----LHISQTWSGDIGT 566
Query: 469 HYNCTAWNSFGPGTAIIQLEEREV 492
Y C ++ G + L R++
Sbjct: 567 -YTCRVISAGGNDSRSAHLRVRQL 589
Score = 34.7 bits (78), Expect = 0.34
Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 13/101 (12%)
Query: 20 QTRFSQEPADQTVVAGQRAVLPCVLLNYSGIV---QWTKDGLALGMGQGLKAWPRYRVVG 76
+TR ++ P DQ+V+ G +A + C + + + W KDG L G ++ PR R+
Sbjct: 495 RTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGATL----GTESHPRIRLDR 550
Query: 77 SADAGQYNLEITDAELSDDASYECQATEAALR-SRRAKLTV 116
+ +L I+ D +Y C+ A SR A L V
Sbjct: 551 NG-----SLHISQTWSGDIGTYTCRVISAGGNDSRSAHLRV 586
Score = 30.8 bits (68), Expect = 4.9
Identities = 40/172 (23%), Positives = 70/172 (40%), Gaps = 12/172 (6%)
Query: 226 TLSIEPQTVQEGERVVFTCQATANPEILGYRWAKGG-FLIEDAHESRYE-TNVDYSFFTE 283
T + Q EG R+V TC A + L ++W L + + E RY T++D +
Sbjct: 30 TEPVRTQVHLEGNRLVLTCMAEGSWP-LEFKWLHNNRELTKFSLEYRYMITSLDRT-HAG 87
Query: 284 PVSCEVHNKVGS-TNVSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGN-PPLTLTW 341
C V N++G+ T V V + K + G + + + P +TW
Sbjct: 88 FYRCIVRNRMGALLQRQTEVQVAYMGSFEEGEKHQSVSHGEAAVIRAPRIASFPQPQVTW 147
Query: 342 TK------KDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPL 387
+ S + ++ N L++ S DAG Y +A+ + G + P+
Sbjct: 148 FRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDKNGDNKTSQPI 199
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 81.6 bits (200), Expect = 2e-15
Identities = 104/441 (23%), Positives = 160/441 (36%), Gaps = 54/441 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ A L C + ++W K G + K PR +
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD---KDDPRSHRMLLPSG 86
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ Y C A S A L V I +D R + V ++ G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-MVAVG 145
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P + C+ P TI W +DG+ + KD + +L+I T
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDD--------KDERITIRGGKLMITYTRKSDAG 197
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+ C N E + EL V P+ V + F C+A +P + R
Sbjct: 198 KYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVR 255
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFA- 307
W K + +SRYE D++ V+ C N VG S + V
Sbjct: 256 WRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 308 --PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------S 351
P VV P+ +G VT C GNP + W ++ S +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 352 NSNQLLLKSVTQADAGTYTCR------AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR 405
+ L + +V ++D G Y C+ +I+ + + +V + PP+I V V
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV-IADRPPPVIRQGPVNQTVA 431
Query: 406 GDGGKVECFIGSTPPPDRIAW 426
DG V + + P I W
Sbjct: 432 VDGTFVLSCVATGSPVPTILW 452
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/386 (23%), Positives = 133/386 (34%), Gaps = 56/386 (14%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
F Q P+D V G+ AV+ C + + W KDG L R + G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGG--- 184
Query: 81 GQYNLEITDAELSDDASYECQATEAA--LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
L IT SD Y C T S A+LTVL P + + +
Sbjct: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
R P T+ W +D EL K L I +
Sbjct: 242 FKCEARG---DPVPTVRWRKD---------DGELPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 199 TCRSMNEAIPSGKETSIELDV-HHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
TC + N + ++ + V PP + Q V G V F C+AT NP+ +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 258 AKGGFLIEDAHE-----SRYE---------TNVDYSFFTEPVSCEVHNKVGST------N 297
+G + +++ SR+ TNV S + C+ N GS
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI-CQTLNVAGSIITKAYLE 408
Query: 298 VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVL 350
V+ ++ P I P T + L+CV G+P T+ W K +DS +
Sbjct: 409 VTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ 468
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVP 376
+ L ++ D G YTC A P
Sbjct: 469 LENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 34.7 bits (78), Expect = 0.34
Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 16/91 (17%)
Query: 299 STLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------------KDS 346
S L F PRIV P G TL C G P T+ W K +
Sbjct: 20 SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 79
Query: 347 NMVLSNSNQLLLKSV----TQADAGTYTCRA 373
M+L + + L+ V ++ D G Y C A
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVA 110
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 81.6 bits (200), Expect = 2e-15
Identities = 104/441 (23%), Positives = 160/441 (36%), Gaps = 54/441 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ A L C + ++W K G + K PR +
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD---KDDPRSHRMLLPSG 86
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ Y C A S A L V I +D R + V ++ G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-MVAVG 145
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P + C+ P TI W +DG+ + KD + +L+I T
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDD--------KDERITIRGGKLMITYTRKSDAG 197
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+ C N E + EL V P+ V + F C+A +P + R
Sbjct: 198 KYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVR 255
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFA- 307
W K + +SRYE D++ V+ C N VG S + V
Sbjct: 256 WRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 308 --PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------S 351
P VV P+ +G VT C GNP + W ++ S +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 352 NSNQLLLKSVTQADAGTYTCR------AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR 405
+ L + +V ++D G Y C+ +I+ + + +V + PP+I V V
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV-IADRPPPVIRQGPVNQTVA 431
Query: 406 GDGGKVECFIGSTPPPDRIAW 426
DG V + + P I W
Sbjct: 432 VDGTFVLSCVATGSPVPTILW 452
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/386 (23%), Positives = 133/386 (34%), Gaps = 56/386 (14%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
F Q P+D V G+ AV+ C + + W KDG L R + G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGG--- 184
Query: 81 GQYNLEITDAELSDDASYECQATEAA--LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
L IT SD Y C T S A+LTVL P + + +
Sbjct: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
R P T+ W +D EL K L I +
Sbjct: 242 FKCEARG---DPVPTVRWRKD---------DGELPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 199 TCRSMNEAIPSGKETSIELDV-HHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
TC + N + ++ + V PP + Q V G V F C+AT NP+ +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 258 AKGGFLIEDAHE-----SRYE---------TNVDYSFFTEPVSCEVHNKVGST------N 297
+G + +++ SR+ TNV S + C+ N GS
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI-CQTLNVAGSIITKAYLE 408
Query: 298 VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVL 350
V+ ++ P I P T + L+CV G+P T+ W K +DS +
Sbjct: 409 VTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ 468
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVP 376
+ L ++ D G YTC A P
Sbjct: 469 LENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 34.7 bits (78), Expect = 0.34
Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 16/91 (17%)
Query: 299 STLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------------KDS 346
S L F PRIV P G TL C G P T+ W K +
Sbjct: 20 SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 79
Query: 347 NMVLSNSNQLLLKSV----TQADAGTYTCRA 373
M+L + + L+ V ++ D G Y C A
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVA 110
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 81.6 bits (200), Expect = 2e-15
Identities = 104/441 (23%), Positives = 160/441 (36%), Gaps = 54/441 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ A L C + ++W K G + K PR +
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD---KDDPRSHRMLLPSG 86
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ Y C A S A L V I +D R + V ++ G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-MVAVG 145
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P + C+ P TI W +DG+ + KD + +L+I T
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDD--------KDERITIRGGKLMITYTRKSDAG 197
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+ C N E + EL V P+ V + F C+A +P + R
Sbjct: 198 KYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVR 255
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFA- 307
W K + +SRYE D++ V+ C N VG S + V
Sbjct: 256 WRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 308 --PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------S 351
P VV P+ +G VT C GNP + W ++ S +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 352 NSNQLLLKSVTQADAGTYTCR------AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR 405
+ L + +V ++D G Y C+ +I+ + + +V + PP+I V V
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV-IADRPPPVIRQGPVNQTVA 431
Query: 406 GDGGKVECFIGSTPPPDRIAW 426
DG V + + P I W
Sbjct: 432 VDGTFVLSCVATGSPVPTILW 452
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/386 (23%), Positives = 133/386 (34%), Gaps = 56/386 (14%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
F Q P+D V G+ AV+ C + + W KDG L R + G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGG--- 184
Query: 81 GQYNLEITDAELSDDASYECQATEAA--LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
L IT SD Y C T S A+LTVL P + + +
Sbjct: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
R P T+ W +D EL K L I +
Sbjct: 242 FKCEARG---DPVPTVRWRKD---------DGELPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 199 TCRSMNEAIPSGKETSIELDV-HHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
TC + N + ++ + V PP + Q V G V F C+AT NP+ +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 258 AKGGFLIEDAHE-----SRYE---------TNVDYSFFTEPVSCEVHNKVGST------N 297
+G + +++ SR+ TNV S + C+ N GS
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI-CQTLNVAGSIITKAYLE 408
Query: 298 VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVL 350
V+ ++ P I P T + L+CV G+P T+ W K +DS +
Sbjct: 409 VTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ 468
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVP 376
+ L ++ D G YTC A P
Sbjct: 469 LENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 34.7 bits (78), Expect = 0.34
Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 16/91 (17%)
Query: 299 STLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------------KDS 346
S L F PRIV P G TL C G P T+ W K +
Sbjct: 20 SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 79
Query: 347 NMVLSNSNQLLLKSV----TQADAGTYTCRA 373
M+L + + L+ V ++ D G Y C A
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVA 110
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 81.6 bits (200), Expect = 2e-15
Identities = 104/441 (23%), Positives = 160/441 (36%), Gaps = 54/441 (12%)
Query: 22 RFSQEPADQTVVAGQRAVLPCVLLNY-SGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
R + P+D V G+ A L C + ++W K G + K PR +
Sbjct: 30 RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETD---KDDPRSHRMLLPSG 86
Query: 81 GQYNLEITDAELS--DDASYECQATE--AALRSRRAKLTVLIPPEDTRIDGGPVILLQAG 136
+ L I S D+ Y C A S A L V I +D R + V ++ G
Sbjct: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV-MVAVG 145
Query: 137 TPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGR 196
P + C+ P TI W +DG+ + KD + +L+I T
Sbjct: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDD--------KDERITIRGGKLMITYTRKSDAG 197
Query: 197 VFTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYR 256
+ C N E + EL V P+ V + F C+A +P + R
Sbjct: 198 KYVCVGTNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP-VPTVR 255
Query: 257 WAKGGFLIEDAHESRYETNVDYSFFTEPVS--------CEVHNKVGSTNVSTLVNVHFA- 307
W K + +SRYE D++ V+ C N VG S + V
Sbjct: 256 WRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGS 312
Query: 308 --PRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVL--------------S 351
P VV P+ +G VT C GNP + W ++ S +L S
Sbjct: 313 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 372
Query: 352 NSNQLLLKSVTQADAGTYTCR------AIVPRIGVAEREVPLYVNGPPIISSEAVQYAVR 405
+ L + +V ++D G Y C+ +I+ + + +V + PP+I V V
Sbjct: 373 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV-IADRPPPVIRQGPVNQTVA 431
Query: 406 GDGGKVECFIGSTPPPDRIAW 426
DG V + + P I W
Sbjct: 432 VDGTFVLSCVATGSPVPTILW 452
Score = 60.5 bits (145), Expect = 6e-09
Identities = 91/386 (23%), Positives = 133/386 (34%), Gaps = 56/386 (14%)
Query: 23 FSQEPADQTVVAGQRAVLPCVLL--NYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADA 80
F Q P+D V G+ AV+ C + + W KDG L R + G
Sbjct: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-----ERITIRGG--- 184
Query: 81 GQYNLEITDAELSDDASYECQATEAA--LRSRRAKLTVLIPPEDTRIDGGPVILLQAGTP 138
L IT SD Y C T S A+LTVL P + + +
Sbjct: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
Query: 139 HNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELLKDGKRETTVSQLLINPTDLDIGRVF 198
R P T+ W +D EL K L I +
Sbjct: 242 FKCEARG---DPVPTVRWRKD---------DGELPKSRYEIRDDHTLKIRKVTAGDMGSY 289
Query: 199 TCRSMNEAIPSGKETSIELDV-HHPPTVTLSIEPQTVQEGERVVFTCQATANPEILGYRW 257
TC + N + ++ + V PP + Q V G V F C+AT NP+ +
Sbjct: 290 TCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWR 349
Query: 258 AKGGFLIEDAHE-----SRYE---------TNVDYSFFTEPVSCEVHNKVGST------N 297
+G + +++ SR+ TNV S + C+ N GS
Sbjct: 350 REGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI-CQTLNVAGSIITKAYLE 408
Query: 298 VSTLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK-------KDSNMVL 350
V+ ++ P I P T + L+CV G+P T+ W K +DS +
Sbjct: 409 VTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ 468
Query: 351 SNSNQLLLKSVTQADAGTYTCRAIVP 376
+ L ++ D G YTC A P
Sbjct: 469 LENGVLQIRYAKLGDTGRYTCIASTP 494
Score = 34.7 bits (78), Expect = 0.34
Identities = 26/91 (28%), Positives = 34/91 (37%), Gaps = 16/91 (17%)
Query: 299 STLVNVHFAPRIVVDPKPTTTDIGSDVTLTCVWVGNPPLTLTWTK------------KDS 346
S L F PRIV P G TL C G P T+ W K +
Sbjct: 20 SRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSH 79
Query: 347 NMVLSNSNQLLLKSV----TQADAGTYTCRA 373
M+L + + L+ V ++ D G Y C A
Sbjct: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVA 110
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,132,928
Number of Sequences: 37866
Number of extensions: 1653706
Number of successful extensions: 9597
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 131
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 6686
Number of HSP's gapped (non-prelim): 2022
length of query: 757
length of database: 18,247,518
effective HSP length: 110
effective length of query: 647
effective length of database: 14,082,258
effective search space: 9111220926
effective search space used: 9111220926
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.