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Search of human proteins with 16554629
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16554629 WD repeat domain 5 [Homo sapiens]
(334 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16554629 WD repeat domain 5 [Homo sapiens] 690 0.0
gi|16554627 WD repeat domain 5 [Homo sapiens] 690 0.0
gi|23199987 WD repeat domain 5B [Homo sapiens] 587 e-168
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 187 1e-47
gi|32189425 WD repeat domain 69 [Homo sapiens] 186 2e-47
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 172 5e-43
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 169 2e-42
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 169 2e-42
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 169 2e-42
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 156 3e-38
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 156 3e-38
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 153 2e-37
gi|26665869 WD repeat domain 51B [Homo sapiens] 149 3e-36
gi|21071067 TBP-associated factor 5 [Homo sapiens] 146 3e-35
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 145 6e-35
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 139 3e-33
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 138 8e-33
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 136 3e-32
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 136 3e-32
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 135 5e-32
gi|113865883 WD repeat domain 38 [Homo sapiens] 134 1e-31
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 132 3e-31
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 132 3e-31
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 127 2e-29
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 126 2e-29
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 126 2e-29
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 126 2e-29
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 124 2e-28
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 123 2e-28
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 123 2e-28
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 690 bits (1780), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
Sbjct: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
Query: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
Sbjct: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
Sbjct: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 690 bits (1780), Expect = 0.0
Identities = 334/334 (100%), Positives = 334/334 (100%)
Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
Sbjct: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
Query: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
Sbjct: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
Sbjct: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334
TDVVISTACHPTENIIASAALENDKTIKLWKSDC
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 587 bits (1514), Expect = e-168
Identities = 284/333 (85%), Positives = 302/333 (90%), Gaps = 4/333 (1%)
Query: 1 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
MAT+E + A+AQ SSSA QSK P PNYALK TL GHT+AVSSVKFSPNGEWL
Sbjct: 1 MATKESRD----AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWL 56
Query: 61 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
ASSSAD+LI IWGAYDGK+EKT+ GH L ISDVAWSSDS+ LVSASDDKTLK+WDV SGK
Sbjct: 57 ASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGK 116
Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
CLKTLKGHSNYVFCCNFNP SNLI+SGSFDE+V+IW+VKTGKCLKTL AHSDPVSAVHFN
Sbjct: 117 CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN 176
Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
GSLIVS SYDGLCRIWD ASGQCLKTL+DDDNPPVSFVKFSPNGKYIL ATLDNTLKL
Sbjct: 177 CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL 236
Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
WDYS+G+CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 237 WDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 296
Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSD 333
TDVVIS ACHPTEN+IASAALENDKTIKLW S+
Sbjct: 297 TDVVISAACHPTENLIASAALENDKTIKLWMSN 329
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 187 bits (474), Expect = 1e-47
Identities = 100/313 (31%), Positives = 165/313 (52%), Gaps = 24/313 (7%)
Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
K+ L+GH V+ V F P + S+S D IK+W G FE+T+ GH + D+++
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
LL S S D T+K+WD +C++T+ GH + V P + IVS S D+++++W+
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--- 214
V+TG C+KT H + V V N+DG+LI S S D R+W A+ +C L + ++
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 215 -----PPVSFVKFS-----------PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258
P S+ S G ++L+ + D T+K+WD S G CL T GH N
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340
Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
+ + +GGK+I+S ++D + +W+ + K ++ L H V S H T + +
Sbjct: 341 VRGVLFH---SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVT 397
Query: 319 AALENDKTIKLWK 331
++ D+T+K+W+
Sbjct: 398 GSV--DQTVKVWE 408
Score = 84.7 bits (208), Expect = 1e-16
Identities = 36/103 (34%), Positives = 62/103 (60%)
Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
G +L S S DK IK+W G T+ GH + V + S ++S +DDKTL++WD
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
+ +C+KTL H ++V +F+ + +V+GS D++V++W+ +
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 186 bits (473), Expect = 2e-47
Identities = 100/293 (34%), Positives = 161/293 (54%), Gaps = 7/293 (2%)
Query: 40 TLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
TL GH V ++ F+ P G+ +A+ S DK K+W GK T GH I ++++
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
S L+ + S D T K+WD+ +G+ + TL+GHS + +FN + I++GSFD +V +WD
Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248
Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
TG+ + L H +S+ FN D SLI++ S D C++WD +G+C+ TL D+ +
Sbjct: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308
Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
F GK I A+ D T +++ + KC+ GH+ E I N G +++GS
Sbjct: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364
Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
D IW+ QT + +Q L+GHTD + S A + NI+ + + D T ++W+
Sbjct: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIWR 415
Score = 175 bits (443), Expect = 6e-44
Identities = 91/291 (31%), Positives = 161/291 (55%), Gaps = 7/291 (2%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD-S 99
L H +++V + +G + S D+ K+W G+ T+ GH+ + +A+++
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147
Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
+ + + S DKT K+W V +GKC T +GH+ + C +FNPQS L+ +GS D + ++WD++
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207
Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
G+ + TL HS + ++ FN G I++ S+D +WD +G+ + LI +S
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI-GHCAEISS 266
Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
F+ + IL ++D T KLWD + GKC+ T TGH +E + + F T GK I + S
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYT-GKLIATASA 323
Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
D I++ T++ + KL+GH + + +P N + + + +DKT ++W
Sbjct: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIW 372
Score = 136 bits (343), Expect = 2e-32
Identities = 72/229 (31%), Positives = 120/229 (52%), Gaps = 5/229 (2%)
Query: 17 PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
P + AT S T K N +TL GH+ + S+ F+ +G+ + + S D + +W
Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
Query: 73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
A G+ + GH IS +++ D +L+++ S DKT K+WD ++GKC+ TL GH + +
Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
F+ LI + S D + RI+ T KC+ L H +S + FN G+ +++ S D
Sbjct: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366
Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
RIWD +GQCL+ L + + F+ G ++ + DNT ++W
Sbjct: 367 KTARIWDAQTGQCLQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 105 bits (262), Expect = 6e-23
Identities = 58/169 (34%), Positives = 88/169 (52%), Gaps = 5/169 (2%)
Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
K L AH P++ V N+ GS ++ SYD C++WDTASG+ L TL N + +P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
G I + D T KLW GKC T+ GH E C+ N T + +GS D
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST---LVATGSMDTTAK 202
Query: 285 IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
+W++Q E V L+GH+ +IS + + + + I + + D T+ +W +D
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDAD 249
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 172 bits (435), Expect = 5e-43
Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%)
Query: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71
A + Q TP + Q+ P A L+GH V KF PNG LAS+ D+LI +
Sbjct: 34 AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92
Query: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
W Y D T+ GH + ++ +++D ++L SAS DKT+ +WD +G+ +K LKGH++
Sbjct: 93 WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152
Query: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187
+V C PQ L+ +GS D +V++WD++ ++T ++ V AV FN I+
Sbjct: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII 209
Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244
S D ++WD + T+ + V+ + S G Y+L+ +DNT+++WD
Sbjct: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
Query: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301
K +C+K + G H EK + ++S G K I +GS D VY+W+ ++ I+ KL GH
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327
Query: 302 DVVISTACHPTENIIASAA 320
+ A HP E II SA+
Sbjct: 328 GSINEVAFHPDEPIIISAS 346
Score = 109 bits (273), Expect = 3e-24
Identities = 61/208 (29%), Positives = 107/208 (51%), Gaps = 9/208 (4%)
Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD 182
L GH V+CC F+P + + S FD + +W+V G C TL HS V +H+N D
Sbjct: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
GS++ S+S D +WD+ +G+ +K L + S + + + D T+KLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302
K ++T+ +N + F+ T + I+SG DN + +W+L+ ++ ++GH D
Sbjct: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
Query: 303 VVISTACHPTENIIASAALENDKTIKLW 330
V + + + S A++N T+++W
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 169 bits (429), Expect = 2e-42
Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)
Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
G + S S D +K+W A GK +T+ GH G+ WSS N+++S S D+TLK+W
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 328
Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
+ +G+C+ TL GH++ V C + + + +VSGS D ++R+WD++TG+CL L H V
Sbjct: 329 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 386
Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
V + DG +VS +YD + ++WD + CL TL N S ++F +G ++++ +L
Sbjct: 387 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 441
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
D ++++WD G C+ T TGH+ S+T G +VSG+ D+ V IW+++
Sbjct: 442 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 491
Query: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
T + +Q LQG H V T +N + +++ +D T+KLW
Sbjct: 492 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 531
Score = 143 bits (360), Expect = 2e-34
Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 17/259 (6%)
Query: 72 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
W + K K + GH + N +VS SDD TLK+W +GKCL+TL GH+
Sbjct: 247 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305
Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
V+ + N+I+SGS D ++++W+ +TG+C+ TL H+ V +H + +VS S
Sbjct: 306 VWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSR 361
Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 362 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 418
Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 419 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 471
Query: 312 TENIIASAALENDKTIKLW 330
+NI+ S D T+K+W
Sbjct: 472 KDNILVSG--NADSTVKIW 488
Score = 107 bits (267), Expect = 1e-23
Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
L GH AV V++ +G + S + D ++K+W T+ GH + + + D
Sbjct: 379 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 434
Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
+VS S D ++++WDV +G C+ TL GH + + N++VSG+ D +V+IWD+KT
Sbjct: 435 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 492
Query: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
G+CL+TL H V+ + FN+ + +++SS DG ++WD +G+ ++ L+
Sbjct: 493 GQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLV 543
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 169 bits (429), Expect = 2e-42
Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)
Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
G + S S D +K+W A GK +T+ GH G+ WSS N+++S S D+TLK+W
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 446
Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
+ +G+C+ TL GH++ V C + + + +VSGS D ++R+WD++TG+CL L H V
Sbjct: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
V + DG +VS +YD + ++WD + CL TL N S ++F +G ++++ +L
Sbjct: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 559
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
D ++++WD G C+ T TGH+ S+T G +VSG+ D+ V IW+++
Sbjct: 560 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 609
Query: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
T + +Q LQG H V T +N + +++ +D T+KLW
Sbjct: 610 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 649
Score = 143 bits (360), Expect = 2e-34
Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 17/259 (6%)
Query: 72 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
W + K K + GH + N +VS SDD TLK+W +GKCL+TL GH+
Sbjct: 365 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
V+ + N+I+SGS D ++++W+ +TG+C+ TL H+ V +H + +VS S
Sbjct: 424 VWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSR 479
Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 480 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 537 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 589
Query: 312 TENIIASAALENDKTIKLW 330
+NI+ S D T+K+W
Sbjct: 590 KDNILVSG--NADSTVKIW 606
Score = 107 bits (267), Expect = 1e-23
Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
L GH AV V++ +G + S + D ++K+W T+ GH + + + D
Sbjct: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
+VS S D ++++WDV +G C+ TL GH + + N++VSG+ D +V+IWD+KT
Sbjct: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
Query: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
G+CL+TL H V+ + FN+ + +++SS DG ++WD +G+ ++ L+
Sbjct: 611 GQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLV 661
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 169 bits (429), Expect = 2e-42
Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)
Query: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
G + S S D +K+W A GK +T+ GH G+ WSS N+++S S D+TLK+W
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 366
Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
+ +G+C+ TL GH++ V C + + + +VSGS D ++R+WD++TG+CL L H V
Sbjct: 367 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424
Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
V + DG +VS +YD + ++WD + CL TL N S ++F +G ++++ +L
Sbjct: 425 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 479
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
D ++++WD G C+ T TGH+ S+T G +VSG+ D+ V IW+++
Sbjct: 480 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 529
Query: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
T + +Q LQG H V T +N + +++ +D T+KLW
Sbjct: 530 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 569
Score = 143 bits (360), Expect = 2e-34
Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 17/259 (6%)
Query: 72 WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
W + K K + GH + N +VS SDD TLK+W +GKCL+TL GH+
Sbjct: 285 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343
Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
V+ + N+I+SGS D ++++W+ +TG+C+ TL H+ V +H + +VS S
Sbjct: 344 VWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSR 399
Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
D R+WD +GQCL L+ V V++ +G+ +++ D +K+WD CL T
Sbjct: 400 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 456
Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
GH N Y + + G +VSGS D + +W+++T + L GH +++
Sbjct: 457 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 509
Query: 312 TENIIASAALENDKTIKLW 330
+NI+ S D T+K+W
Sbjct: 510 KDNILVSG--NADSTVKIW 526
Score = 107 bits (267), Expect = 1e-23
Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
L GH AV V++ +G + S + D ++K+W T+ GH + + + D
Sbjct: 417 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 472
Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
+VS S D ++++WDV +G C+ TL GH + + N++VSG+ D +V+IWD+KT
Sbjct: 473 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 530
Query: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
G+CL+TL H V+ + FN+ + +++SS DG ++WD +G+ ++ L+
Sbjct: 531 GQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLV 581
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 156 bits (394), Expect = 3e-38
Identities = 102/312 (32%), Positives = 165/312 (52%), Gaps = 13/312 (4%)
Query: 25 QSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83
+ KP P + P LK TL AV +V+F+ +G + + +DK +K+W G +T
Sbjct: 5 EPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63
Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143
SGH + D A S D++ L S DK + +WDV+SG+ ++ +GH+ V FN ++ +
Sbjct: 64 SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123
Query: 144 IVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
I+SGS D S+R WD ++ + ++TL D VS+V + I++ S DG R +D
Sbjct: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLR 181
Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
GQ + P++ FS +G+ L ++LD+TL+L D G+ L Y GHKN++Y
Sbjct: 182 MGQLFSDYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
+ S +VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 239 LDCCLS-ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAM- 296
Query: 322 ENDKTIKLWKSD 333
+++ W+ +
Sbjct: 297 --GGSVQCWREE 306
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 156 bits (394), Expect = 3e-38
Identities = 102/312 (32%), Positives = 165/312 (52%), Gaps = 13/312 (4%)
Query: 25 QSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83
+ KP P + P LK TL AV +V+F+ +G + + +DK +K+W G +T
Sbjct: 5 EPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63
Query: 84 SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143
SGH + D A S D++ L S DK + +WDV+SG+ ++ +GH+ V FN ++ +
Sbjct: 64 SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123
Query: 144 IVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
I+SGS D S+R WD ++ + ++TL D VS+V + I++ S DG R +D
Sbjct: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLR 181
Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
GQ + P++ FS +G+ L ++LD+TL+L D G+ L Y GHKN++Y
Sbjct: 182 MGQLFSDYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238
Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
+ S +VS SED V+ W+L + L + VV S A HPTE + +A
Sbjct: 239 LDCCLS-ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAM- 296
Query: 322 ENDKTIKLWKSD 333
+++ W+ +
Sbjct: 297 --GGSVQCWREE 306
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 153 bits (386), Expect = 2e-37
Identities = 90/252 (35%), Positives = 139/252 (55%), Gaps = 8/252 (3%)
Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVA 94
A +FT GH AV+ V FSP+G LAS S DK ++IW + K E T+ H + V
Sbjct: 16 AYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVH 72
Query: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
+ SD V+ASDDKT+K+W K L +L H N+V C F+P LIVS S D++V+
Sbjct: 73 FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 132
Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
+WD + +C+ + H V+ V F+ G+ I ++ D ++WD + + L+ +
Sbjct: 133 LWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-YQLHS 191
Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
V+ + F P+G Y++ A+ D+TLK+ D +G+ L T GH+ + FS T G++
Sbjct: 192 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYF 248
Query: 275 VSGSEDNLVYIW 286
SG D V +W
Sbjct: 249 ASGGSDEQVMVW 260
Score = 117 bits (292), Expect = 2e-26
Identities = 76/268 (28%), Positives = 130/268 (48%), Gaps = 6/268 (2%)
Query: 66 DKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
D + +W +GHK ++ V +S +LL S S DKT++IW +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
+ H+ V +F V+ S D++V++W K L +L H + V F+ DG L
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
IVS+S D ++WD +S +C+ + + V++V F P+G I AA +DNT+K+WD
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
+ L+ Y H + + S G ++++ S D+ + I +L ++ L GH
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPS---GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237
Query: 306 STACHPTENIIASAALENDKTIKLWKSD 333
+ A T AS +D+ + +WKS+
Sbjct: 238 TVAFSRTGEYFASGG--SDEQVMVWKSN 263
Score = 45.1 bits (105), Expect = 9e-05
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 7/98 (7%)
Query: 234 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
+D+ L +W +TGHK+ C+ NFS G + SGS D V IW K
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCV--NFS-PSGHLLASGSRDKTVRIWVPNVKGE 57
Query: 294 VQKLQGHTDVVIST-ACHPTENIIASAALENDKTIKLW 330
+ HT V S C ++ + ++ +DKT+K+W
Sbjct: 58 STVFRAHTATVRSVHFCSDGQSFVTAS---DDKTVKVW 92
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 149 bits (377), Expect = 3e-36
Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 6/291 (2%)
Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
GH A++S+ SPNG+ LA++S D + +W GHK ++ V +S NLL
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
SAS D+T+++W K H+ V +F+ + + S D+S+++W + +
Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222
L +L H+ V F+ DG LIVS S D +IWDT + QC+ D +FV F
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN-FSDSVGFANFVDF 194
Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
+P+G I +A D T+K+WD K L+ Y H CI + S G ++++ S D
Sbjct: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251
Query: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
+ I +L ++ LQGHT V + + + AS D + LW+++
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300
Score = 147 bits (372), Expect = 1e-35
Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 6/260 (2%)
Query: 35 YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDV 93
+A + GH V+SV+FSP+G LAS+S D+ +++W GKF + H + V
Sbjct: 50 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSV 108
Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
+S+D L +AS+DK++K+W + + L +L H+++V C F+P LIVS S D+++
Sbjct: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168
Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
+IWD +C+ + V FN G+ I S+ D ++WD + L+
Sbjct: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVH 227
Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
+ V+ + F P+G Y++ A+ D TLK+ D +G+ + T GH + + +FS GG+
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGEL 284
Query: 274 IVSGSEDNLVYIWNLQTKEI 293
SG D V +W E+
Sbjct: 285 FASGGADTQVLLWRTNFDEL 304
Score = 118 bits (295), Expect = 8e-27
Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%)
Query: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
D E+ GHK I+ + S + L +AS D L +W+ GH + V
Sbjct: 7 DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66
Query: 136 NFNPQSNLIVSGSFDESVRIW-DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
F+P NL+ S S D +VR+W K GK AH+ PV +V F+ DG + ++S D
Sbjct: 67 QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125
Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
++W + L +L + V KFSP+G+ I++ + D T+K+WD + +C+ ++
Sbjct: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183
Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
+ + F +F+ G I S D V +W+++ +++Q Q H+ V + HP+ N
Sbjct: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241
Query: 315 IIASAALENDKTIKL 329
+ +A+ +D T+K+
Sbjct: 242 YLITAS--SDGTLKI 254
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 146 bits (368), Expect = 3e-35
Identities = 86/292 (29%), Positives = 147/292 (50%), Gaps = 17/292 (5%)
Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
+T + +++V + + +A AD +++W K + V +SD
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASD 512
Query: 99 SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
+L+ SDD +I D + LK L GHS V+ +F+P N ++S S D +VR+W +
Sbjct: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572
Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
+T CL H+ PV F+ G VS +D + R+W T Q L+ + V+
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVN 631
Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
+F PN Y+ + D T++LWD G C++ +TGHK + + FS G+++ +G+
Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGA 688
Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
D V +W++ +V +L+GHTD V S I+AS +++N T++LW
Sbjct: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLW 738
Score = 122 bits (305), Expect = 6e-28
Identities = 66/223 (29%), Positives = 106/223 (47%), Gaps = 7/223 (3%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
L GH+ V FSP+ +L SSS D +++W GH + D +S
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
VS D+ ++W + L+ GH V C F+P SN + +GS D +VR+WDV
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
G C++ H P+ ++ F+ +G + + + DG +WD G + L V +
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGHTDTVCSL 717
Query: 221 KFSPNGKYILAATLDNTLKLWDYSKG------KCLKTYTGHKN 257
+FS +G+ + + ++DNT++LWD K T TGH N
Sbjct: 718 RFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760
Score = 115 bits (289), Expect = 4e-26
Identities = 68/242 (28%), Positives = 115/242 (47%), Gaps = 4/242 (1%)
Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
K + SVK + + + S D L +I K + GH + ++S D N L+S+
Sbjct: 502 KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS 561
Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
S+D T+++W + + CL KGH+ V+ F+P VSG D R+W + L+
Sbjct: 562 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621
Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
H V+ F+ + + + + S D R+WD +G C++ + P+ + FSPN
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPN 680
Query: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
G+++ D + LWD G + GH + + FS G+ + SGS DN V +
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL--RFS-RDGEILASGSMDNTVRL 737
Query: 286 WN 287
W+
Sbjct: 738 WD 739
Score = 109 bits (272), Expect = 4e-24
Identities = 53/192 (27%), Positives = 95/192 (49%), Gaps = 3/192 (1%)
Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
GH V +FSP G + S D++ ++W + + +GH ++ + +SN +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642
Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
+ S D+T+++WDV +G C++ GH + F+P + +G+ D V +WD+ G
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702
Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVSFVK 221
+ L H+D V ++ F+RDG ++ S S D R+WD + L+T DD +
Sbjct: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760
Query: 222 FSPNGKYILAAT 233
N + +L T
Sbjct: 761 LPENSQELLLGT 772
Score = 89.4 bits (220), Expect = 4e-18
Identities = 49/174 (28%), Positives = 86/174 (49%), Gaps = 24/174 (13%)
Query: 42 AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
AGH V+ +F PN ++A+ SAD+ +++W +G + +GHK I + +S +
Sbjct: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683
Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKT 160
L + + D + +WD+ G + LKGH++ V F+ ++ SGS D +VR+WD +K
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743
Query: 161 GKCLKT-----------LPAHSD------------PVSAVHFNRDGSLIVSSSY 191
+ L+T LP +S PV +HF R ++ + +Y
Sbjct: 744 FEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/198 (25%), Positives = 79/198 (39%), Gaps = 35/198 (17%)
Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-------------------DTASG 203
C T ++AV D SLI D R+W D S
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
Query: 204 QCLKTLIDD-----------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
L+ ++D+ + PV FSP+ Y+L+++ D T++LW CL Y
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
GH Y ++ G + VSG D + +W + ++ GH V T HP
Sbjct: 582 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638
Query: 313 ENIIASAALENDKTIKLW 330
N +A+ + D+T++LW
Sbjct: 639 SNYVATGSA--DRTVRLW 654
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 145 bits (365), Expect = 6e-35
Identities = 90/317 (28%), Positives = 157/317 (49%), Gaps = 21/317 (6%)
Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL- 88
P + + +KF H V +FSP+G++L + S D I++W GK K +
Sbjct: 202 PTQLSRHIKFGQKSH---VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 258
Query: 89 -------GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQ 140
+ + +S D+ +L + + D +K+W + SG+CL+ + HS V C +F+
Sbjct: 259 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 318
Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
S+ I+S SFD+++RI +K+GK LK HS V+ F +DG I+S+S DG +IW+
Sbjct: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
Query: 201 ASGQCLKTL------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
+ +C T D S + N ++ + NT+ + + +G+ +++++
Sbjct: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSS 437
Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
K E G+WI ED ++Y ++ T ++ + L H VI A HP +N
Sbjct: 438 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN 497
Query: 315 IIASAALENDKTIKLWK 331
+IA+ D +KLWK
Sbjct: 498 LIAT--YSEDGLLKLWK 512
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 139 bits (351), Expect = 3e-33
Identities = 90/327 (27%), Positives = 159/327 (48%), Gaps = 22/327 (6%)
Query: 21 SSATQSKPTPVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
+SA +K P P + L ++GH V + P +W + SAD+ IKIW
Sbjct: 174 NSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL 233
Query: 75 YDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC 134
GK + +++GH + V S+ S L S +DK +K WD+ K ++ GH + V+
Sbjct: 234 ASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYG 293
Query: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
+ +P +++V+ S D + RIWDV+T + TL H++ V+ V I++ S+D
Sbjct: 294 LDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTT 353
Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
R+WD +G+ TL + V V P Y A+ + +K W + G ++ +G
Sbjct: 354 IRLWDLVAGKTRVTL-TNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSG 411
Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VIS 306
H I +V +VSG+++ +++W+ +T Q++ G D + +
Sbjct: 412 HN----AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467
Query: 307 TACHPTENIIASAALENDKTIKLWKSD 333
A +E+ + +A E DKTIK+++ D
Sbjct: 468 CAFDQSESRLLTA--EADKTIKVYRED 492
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 138 bits (347), Expect = 8e-33
Identities = 89/315 (28%), Positives = 152/315 (48%), Gaps = 7/315 (2%)
Query: 16 QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75
QP P+ + ++ +P K +Y LK H VS V P+ + L S D+L K+ G
Sbjct: 323 QPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLP 382
Query: 76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
T GH +SD + + L ++S D T+K+WD+ G C+ T +GHS V+ C
Sbjct: 383 KCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSC 442
Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
++ N + S S D++ +IWDV + +C TL H+D V+++ F + +++SS D
Sbjct: 443 TWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
IWD +G C ++L + ++ F P G I + KLWD+ K L +
Sbjct: 503 SIWDARTGICEQSLYGHMH-SINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSID 559
Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
NF + G+ + S + ++++ +L++ EI KL GH + + I
Sbjct: 560 IGPSPGNEVNFD-SSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEI 617
Query: 316 IASAALENDKTIKLW 330
+ S +D T++ W
Sbjct: 618 LFSGG--SDGTVRTW 630
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 136 bits (342), Expect = 3e-32
Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)
Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89
P + +L+ GH AV+ V FS N + LAS S D + +W +GHK
Sbjct: 4 PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
++ V +S +LL S S DKT++IW + + H+ V +F V+ S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
D++V++W K L +L H + V F+ DG LIVS+S D ++WD +S +C+ +
Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
+ V++V F P+G I AA +DNT+K+WD + L+ Y H + + S
Sbjct: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240
Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
G ++++ S D+ + I +L ++ L GH + A T AS +D+ + +
Sbjct: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297
Query: 330 WKSD 333
WKS+
Sbjct: 298 WKSN 301
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 136 bits (342), Expect = 3e-32
Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)
Query: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89
P + +L+ GH AV+ V FS N + LAS S D + +W +GHK
Sbjct: 4 PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63
Query: 90 ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
++ V +S +LL S S DKT++IW + + H+ V +F V+ S
Sbjct: 64 VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123
Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
D++V++W K L +L H + V F+ DG LIVS+S D ++WD +S +C+ +
Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
+ V++V F P+G I AA +DNT+K+WD + L+ Y H + + S
Sbjct: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240
Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
G ++++ S D+ + I +L ++ L GH + A T AS +D+ + +
Sbjct: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297
Query: 330 WKSD 333
WKS+
Sbjct: 298 WKSN 301
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 135 bits (340), Expect = 5e-32
Identities = 79/299 (26%), Positives = 143/299 (47%), Gaps = 13/299 (4%)
Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL- 101
G + +S FSPN + LA++ L K+W D T+ GH + + + S +
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288
Query: 102 -------LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
L S + D ++K+W + S + + ++GH+ V ++P + + +D S R
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348
Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
+WD++ + + HS V + F++DGSL + D R+WD +G+C+ ++
Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-MFLEGHL 407
Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
+ + FSPNG +I + DNT K+WD + +C+ T H+N F G ++
Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIHGNFL 465
Query: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
++G+ DN IW ++ L GH V+ +IA+ + D+T KLW ++
Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLWMAE 522
Score = 126 bits (317), Expect = 2e-29
Identities = 74/263 (28%), Positives = 127/263 (48%), Gaps = 13/263 (4%)
Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEW--------LASSSADKLIKIWGAYDGKFEKTIS 84
P+ L TL GH V ++ F P LAS +AD +K+W + I
Sbjct: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320
Query: 85 GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
GH + ++ V W L + D++ ++WD+ + + + +GHS V+ F+ +L
Sbjct: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380
Query: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
+G D R+WD++TG+C+ L H + ++F+ +G I + S D C++WD +
Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440
Query: 205 CLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263
C+ T+ N V+ VKF P +G ++L DNT K+W + LKT GH+ + +
Sbjct: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496
Query: 264 ANFSVTGGKWIVSGSEDNLVYIW 286
+ G+ I + S D +W
Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519
Score = 32.3 bits (72), Expect = 0.61
Identities = 15/42 (35%), Positives = 24/42 (57%)
Query: 33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
P ++ TLAGH V + S +G+ +A+ S D+ K+W A
Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 134 bits (337), Expect = 1e-31
Identities = 79/285 (27%), Positives = 139/285 (48%), Gaps = 8/285 (2%)
Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
H V+S FSP+G+ L + S D + W G+ + GH + +S D +L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79
Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
SAS D T+++WDV+ KCL+ LKGH V +F+P S + SG +D+ V +WDV++G+
Sbjct: 80 SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139
Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDDNPPVSFVK 221
L+ L H D + + F+ + + + S+D IWD + ++ + +S +
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSED 280
+S +G + + + D T+ +W + L GH K F+ + W+ S
Sbjct: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLASAGYS 254
Query: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325
+V +W+ T + ++ L+G DV + A P I+ S A + +
Sbjct: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299
Score = 133 bits (335), Expect = 2e-31
Identities = 83/251 (33%), Positives = 130/251 (51%), Gaps = 16/251 (6%)
Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
L + L GHT V +FSP+G AS+S D +++W K + + GH+ + V++S
Sbjct: 55 LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114
Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
DS L S DK + +WDV SG+ L+ L GH + + +F+P N + +GS+D +V IW
Sbjct: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174
Query: 157 D---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
D V + L HS +S + ++ G L+ S S+D IW + L L
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---- 229
Query: 214 NPPVSFVK---FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVT 269
V++VK FSP+ ++ +A +K+WD + GKCL+T G + + C F
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TP 285
Query: 270 GGKWIVSGSED 280
GK +VSG+ D
Sbjct: 286 DGKILVSGAAD 296
Score = 127 bits (319), Expect = 1e-29
Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 12/257 (4%)
Query: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
K H ++ A+S D +L++ S+D + W+ SG+ L L GH+ V C F+P
Sbjct: 15 KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74
Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
+L S S D +VR+WDV KCL+ L H V V F+ D + S +D +WD
Sbjct: 75 GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKN 257
SGQ L+ L+ + FSP + + D+T+ +WD + + GH
Sbjct: 135 QSGQMLRLLV-GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317
C+ +S +G + SGS D ++IW T ++ +L+GH V S A P E +A
Sbjct: 194 NISCLC--YSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLA 249
Query: 318 SAALENDKTIKLWKSDC 334
SA + +K+W DC
Sbjct: 250 SAGY--SRMVKVW--DC 262
Score = 97.1 bits (240), Expect = 2e-20
Identities = 54/167 (32%), Positives = 92/167 (55%), Gaps = 6/167 (3%)
Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
+K H V++ F+ DG ++++ S DG W+T SGQ L L PV F +FS
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72
Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
P+G +A+ D T++LWD ++ KCL+ GH+ + +FS + + SG D V
Sbjct: 73 PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129
Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
+W++Q+ ++++ L GH D + S+ PT N +A+ + D T+ +W
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174
Score = 79.7 bits (195), Expect = 3e-15
Identities = 42/114 (36%), Positives = 63/114 (55%), Gaps = 1/114 (0%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
L GH+ +S + +S +G LAS S DK I IW + GH + +A+S D
Sbjct: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL 246
Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
L SA + +K+WD ++GKCL+TLKG + C F P ++VSG+ D++ R
Sbjct: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 51.6 bits (122), Expect = 1e-06
Identities = 26/75 (34%), Positives = 41/75 (54%)
Query: 36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
+L L GH V S+ FSP+ WLAS+ +++K+W GK +T+ G A+
Sbjct: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283
Query: 96 SSDSNLLVSASDDKT 110
+ D +LVS + D+T
Sbjct: 284 TPDGKILVSGAADQT 298
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 132 bits (333), Expect = 3e-31
Identities = 84/299 (28%), Positives = 145/299 (48%), Gaps = 15/299 (5%)
Query: 42 AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDS 99
+GHTK VS+V+ P +G L S S D IK+W Y + + +T GH + D+ +++
Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344
Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIW 156
+SA+ D+ LK+WD +G+C+ +C FNP + NL V+G D+ + W
Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQW 403
Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
D+++G+ ++ H V+ + F + VS+S D R+W+ K + +
Sbjct: 404 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463
Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKW 273
+ V SPNGK++ ++DN + ++ L K + GH Y +FS +
Sbjct: 464 MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSY 522
Query: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP--TENIIASAALENDKTIKLW 330
++SG + + IW+ +T ++ + + H V I HP T +I D IKLW
Sbjct: 523 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 132 bits (333), Expect = 3e-31
Identities = 89/307 (28%), Positives = 153/307 (49%), Gaps = 32/307 (10%)
Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
+L GH++AV SV FSP G++LAS S D ++ W T GH+ + ++WS D
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168
Query: 100 NLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNF-----NPQSNLIVSGSFDESV 153
L S + + +WD S+GK + +TL GHS ++ ++ NP+ + S S D SV
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
RIWD G+C + L H+ V+ + + DG L+ S+S D ++W G +TL
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL---- 283
Query: 214 NPPVSFVKFSPNGKYI--LAATLDNTLKLWDYSKGKCL---KTYTGHKNE-KYCIFANFS 267
+G ++ +A + D L+ + + + G E K + ++
Sbjct: 284 ---------QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334
Query: 268 VTGGKW---IVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323
+ G+ +VSGS+D +++W+ + K+ + ++ GH ++ P I+ASA+
Sbjct: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF-- 392
Query: 324 DKTIKLW 330
DK+IKLW
Sbjct: 393 DKSIKLW 399
Score = 130 bits (326), Expect = 2e-30
Identities = 89/341 (26%), Positives = 154/341 (45%), Gaps = 54/341 (15%)
Query: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-FEKTISGHKLGISDVAW-- 95
FT GH V S+ +SP+G LAS + I +W GK +T++GH I+ ++W
Sbjct: 150 FTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209
Query: 96 ---SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
+ + + S+S D +++IWD ++G+C + L GH+ V C + L+ S S D +
Sbjct: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRT 268
Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRD---------------------GSL------ 185
+++W G +TL H V+ + + D GSL
Sbjct: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328
Query: 186 ---------------IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230
+VS S D +W A + T + ++ V FSP+ + +
Sbjct: 329 ALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388
Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
+A+ D ++KLWD GK L + GH Y I + + +VSGS D+ + +W+++
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS---ADSRLLVSGSSDSTLKVWDVKA 445
Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
+++ L GH D V + P +AS DK +++W+
Sbjct: 446 QKLAMDLPGHADEVYAVDWSPDGQRVASGG--KDKCLRIWR 484
Score = 90.5 bits (223), Expect = 2e-18
Identities = 52/208 (25%), Positives = 100/208 (48%), Gaps = 10/208 (4%)
Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
+C +L+GHS V F+P + SGS D +VR WD+ T T H V ++ +
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-----SPNGKYILAATL 234
+ DG + S +G +WD ++G+ + + + ++ + + +P +Y+ +++
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
D ++++WD + G+C + TGH C+ G + S S+D + +W +
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCL----RWGGDGLLYSASQDRTIKVWRAHDGVLC 280
Query: 295 QKLQGHTDVVISTACHPTENIIASAALE 322
+ LQGH V +T T+ + + A E
Sbjct: 281 RTLQGHGHWV-NTMALSTDYALRTGAFE 307
Score = 51.2 bits (121), Expect = 1e-06
Identities = 48/217 (22%), Positives = 89/217 (41%), Gaps = 29/217 (13%)
Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS------ 190
F + ++ FD V I + L A DP+ F D ++ S
Sbjct: 21 FQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQ 80
Query: 191 -----------YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239
Y A +C +L + + V V FSP GKY+ + + D T++
Sbjct: 81 AVETEKVLDIIYQPQAIFRVRAVTRCTSSL-EGHSEAVISVAFSPTGKYLASGSGDTTVR 139
Query: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQ 298
WD S T GH++ + + ++S G K + SG ++ + +W+ T K++ + L
Sbjct: 140 FWDLSTETPHFTCKGHRH--WVLSISWSPDGRK-LASGCKNGQILLWDPSTGKQVGRTLA 196
Query: 299 GHTDVVISTACHPTE-----NIIASAALENDKTIKLW 330
GH+ + + P +AS++ D ++++W
Sbjct: 197 GHSKWITGLSWEPLHANPECRYVASSS--KDGSVRIW 231
Score = 34.7 bits (78), Expect = 0.12
Identities = 15/36 (41%), Positives = 22/36 (61%)
Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
L L GH V +V +SP+G+ +AS DK ++IW
Sbjct: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 127 bits (318), Expect = 2e-29
Identities = 77/263 (29%), Positives = 129/263 (49%), Gaps = 15/263 (5%)
Query: 46 KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
K V+S+ ++ G LA+ S D +IW DG T+ HK I + W+ N ++SA
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284
Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
DKT IWD +G+ + HS ++ +N S S D + + + + +K
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343
Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
T H++ V+A+ ++ G+L+ S S D +IW C+ L N + +K+SP
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL-QAHNKEIYTIKWSPT 402
Query: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
G + +A+ D+T++LWD +G C+ T T H+ Y + + G+++ S
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS---PDGRYLAS 459
Query: 277 GSEDNLVYIWNLQTKEIVQKLQG 299
GS D V+IWN QT +V +G
Sbjct: 460 GSFDKCVHIWNTQTGALVHSYRG 482
Score = 123 bits (309), Expect = 2e-28
Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 11/227 (4%)
Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
L TL H + ++K++ G ++ S+ DK IW A+ G+ ++ H DV W
Sbjct: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317
Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
S+ N S S D + + + + +KT +GH+N V ++P NL+ S S D +++IW
Sbjct: 318 SN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376
Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207
+K C+ L AH+ + + ++ G ++ S+S+D R+WD G C+
Sbjct: 377 SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH 436
Query: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
TL P S V FSP+G+Y+ + + D + +W+ G + +Y G
Sbjct: 437 TLTKHQEPVYS-VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482
Score = 104 bits (259), Expect = 1e-22
Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 24/221 (10%)
Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-----------CLKT----LPA 169
L+GH + VF C +NP S+L+ SGS D + RIW++ C++ +P+
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224
Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229
+ D V+++ +N +G+L+ + SYDG RIW T G TL P+ +K++ G +I
Sbjct: 225 NKD-VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTL-GQHKGPIFALKWNKKGNFI 281
Query: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289
L+A +D T +WD G+ + + H + + T S S D +++ L
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT----FASCSTDMCIHVCKLG 337
Query: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
++ QGHT+ V + PT N++AS + +D T+K+W
Sbjct: 338 QDRPIKTFQGHTNEVNAIKWDPTGNLLASCS--DDMTLKIW 376
Score = 57.8 bits (138), Expect = 1e-08
Identities = 35/128 (27%), Positives = 62/128 (48%), Gaps = 10/128 (7%)
Query: 41 LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
L H K + ++K+SP G LAS+S D +++W G T++ H+ +
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446
Query: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
VA+S D L S S DK + IW+ +G + + +G C +N + + + + D
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC-WNAAGDKVGASASDG 505
Query: 152 SVRIWDVK 159
SV + D++
Sbjct: 506 SVCVLDLR 513
Score = 48.9 bits (115), Expect = 6e-06
Identities = 26/77 (33%), Positives = 43/77 (55%), Gaps = 1/77 (1%)
Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
TL H + V SV FSP+G +LAS S DK + IW G + G GI +V W++
Sbjct: 437 TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG-GIFEVCWNAAG 495
Query: 100 NLLVSASDDKTLKIWDV 116
+ + +++ D ++ + D+
Sbjct: 496 DKVGASASDGSVCVLDL 512
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 126 bits (317), Expect = 2e-29
Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 306
Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++
Sbjct: 307 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 364
Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V
Sbjct: 365 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 417
Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 418 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 468
Score = 112 bits (280), Expect = 5e-25
Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)
Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 355 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 412
Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 413 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 468
Query: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
D++ CL+TL HS V + F D I+SSS+D IWD
Sbjct: 469 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 518
Score = 108 bits (271), Expect = 5e-24
Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)
Query: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+
Sbjct: 251 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 308
Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
+G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 366
Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
+ V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ +
Sbjct: 367 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 421
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ
Sbjct: 422 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 471
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 126 bits (317), Expect = 2e-29
Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272
Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++
Sbjct: 273 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330
Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V
Sbjct: 331 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 383
Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 384 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 434
Score = 112 bits (280), Expect = 5e-25
Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)
Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378
Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 379 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434
Query: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
D++ CL+TL HS V + F D I+SSS+D IWD
Sbjct: 435 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484
Score = 108 bits (271), Expect = 5e-24
Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)
Query: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+
Sbjct: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 274
Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
+G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332
Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
+ V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ +
Sbjct: 333 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 387
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ
Sbjct: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 437
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 126 bits (317), Expect = 2e-29
Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)
Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
D ++S D ++KIWD +S +CLK L GH+ V C ++ + +IV+GS D +VR+WD
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293
Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
V TG+ L TL H++ V +H L+V+ S D +WD AS L+ ++
Sbjct: 294 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351
Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
V+ V F + KYI++A+ D T+K+W S + ++T GHK C+ + +V
Sbjct: 352 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 404
Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
SGS DN + +W+++ ++ L+GH ++V C +N I++ A D IK+W
Sbjct: 405 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 455
Score = 112 bits (280), Expect = 5e-25
Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)
Query: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
L+ L GH AV+ V F + +++ S+S D+ IK+W +F +T++GHK GI+ + +
Sbjct: 342 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399
Query: 97 SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
L+VS S D T+++WD+ G CL+ L+GH V C F+ + IVSG++D +++W
Sbjct: 400 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455
Query: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
D++ CL+TL HS V + F D I+SSS+D IWD
Sbjct: 456 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505
Score = 108 bits (271), Expect = 5e-24
Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)
Query: 58 EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
E + S D IKIW + K ++GH + + + D ++V+ S D T+++WDV+
Sbjct: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 295
Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
+G+ L TL H+ V F+ + L+V+ S D S+ +WD+ + + + L H V
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353
Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
+ V F D IVS+S D ++W T++ + ++TL + ++ +++ + +++ +
Sbjct: 354 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 408
Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
DNT++LWD G CL+ GH+ CI F N K IVSG+ D + +W+LQ
Sbjct: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 458
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 124 bits (310), Expect = 2e-28
Identities = 83/300 (27%), Positives = 145/300 (48%), Gaps = 17/300 (5%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDS 99
L+GH AVS+ F + L S S D +K+W DG + K + + + + DS
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157
Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWDV 158
+ +++AS DKT++ WD+ +GK L ++ + ++ C F+P +VSG D + I D
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216
Query: 159 KTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
+ + + H + +++ F+ D + S S D +IWD S L T+ + +
Sbjct: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276
Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTG 270
S F+ +G ++ ++ D LK+W+ G+ C+ GH+ C FA S
Sbjct: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333
Query: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
+++SG D V IW++ L+GH D V+ A + I SA+ D+T++LW
Sbjct: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390
Score = 111 bits (278), Expect = 8e-25
Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 10/204 (4%)
Query: 48 VSSVKFSPNGEWLASS-SADKLIKIWGAYDGKFEKTISGHKL-GISDVAWSSDSNLLVSA 105
+ S KFSP+G+++ S D I I A + I H I+ + DS + S
Sbjct: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248
Query: 106 SDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-- 162
S D+ +KIWDV+S L T+ K HSN + C F + + + S+D++++IW+V TG+
Sbjct: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308
Query: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
C+ + H VS+ HF RD S ++S +D IWD A G K + N V
Sbjct: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367
Query: 219 FVKFSPNGKYILAATLDNTLKLWD 242
V S N K+IL+A+ D T++LW+
Sbjct: 368 DVAISNNKKWILSASKDRTMRLWN 391
Score = 100 bits (249), Expect = 2e-21
Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 7/163 (4%)
Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102
HT++++S F P+ + +AS S D+ IKIW TI+ H IS+ ++ + L
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
Query: 103 VSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
++S DK LKIW+V +G+ C+ ++GH V C+F S+ ++SG FD +V IW
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
DV G +L H+D V V + + I+S+S D R+W+
Sbjct: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
Score = 81.6 bits (200), Expect = 9e-16
Identities = 40/122 (32%), Positives = 72/122 (59%), Gaps = 6/122 (4%)
Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97
H+ A+S+ F+ +G +L +SS DK +KIW + G+F + GH+ +S ++
Sbjct: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331
Query: 98 DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
DS+ L+S D+T+ IWDV+ G +LKGH+++V + I+S S D ++R+W+
Sbjct: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391
Query: 158 VK 159
++
Sbjct: 392 IE 393
Score = 75.5 bits (184), Expect = 6e-14
Identities = 67/261 (25%), Positives = 106/261 (40%), Gaps = 61/261 (23%)
Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH-SDPVSAVHFNR 181
K L GH + V C+F ++SGS+D +V++WD G ++ PV
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155
Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL----------- 230
D S ++++SYD R WD +G+ L + D + KFSP+GKY++
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTF--IVSCKFSPDGKYVVSGFDVDHGICI 213
Query: 231 ---------------------------------AATLDNTLKLWDYSKGKCLKTYT-GHK 256
+ +LD +K+WD + L T T H
Sbjct: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273
Query: 257 NE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------VQKLQGHTDVVISTAC 309
N C F FS G ++ + S D + IWN+ T E V +QGH V ++C
Sbjct: 274 NAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV--SSC 327
Query: 310 HPTENIIASAALENDKTIKLW 330
H + + D+T+ +W
Sbjct: 328 HFARDSSFLISGGFDRTVAIW 348
Score = 56.2 bits (134), Expect = 4e-08
Identities = 24/76 (31%), Positives = 46/76 (60%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
+ GH +VSS F+ + +L S D+ + IW +G + ++ GH + DVA S++
Sbjct: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376
Query: 101 LLVSASDDKTLKIWDV 116
++SAS D+T+++W++
Sbjct: 377 WILSASKDRTMRLWNI 392
Score = 33.5 bits (75), Expect = 0.27
Identities = 13/35 (37%), Positives = 21/35 (60%)
Query: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
K +L GH V V S N +W+ S+S D+ +++W
Sbjct: 356 KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 123 bits (309), Expect = 2e-28
Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 19/275 (6%)
Query: 27 KPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85
K T + NY + + L GH+ VS V S +G++ S S D +++W G + G
Sbjct: 44 KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103
Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN- 142
H + VA+SSD+ +VS S DKT+K+W+ + G C T++ HS +V C F+P S+
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSN 162
Query: 143 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
+IVS +D+ V++W++ K H+ ++ V + DGSL S DG +WD
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-------TG 254
G+ L TL D ++ + FSPN +Y L A ++K+WD +GK + T
Sbjct: 223 EGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTS 278
Query: 255 HKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
K E C +S G + + +G DNLV +W +
Sbjct: 279 SKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312
Score = 112 bits (281), Expect = 4e-25
Identities = 86/282 (30%), Positives = 141/282 (50%), Gaps = 20/282 (7%)
Query: 37 LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90
L+ TL GH V+ + +P + + S+S DK I +W G ++ + GH +
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
Query: 91 SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
SDV SSD +S S D TL++WD+++G + GH+ V F+ + IVSGS D
Sbjct: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126
Query: 151 ESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCL 206
+++++W+ G C T+ +HS+ VS V F N +IVS +D L ++W+ A+ + L
Sbjct: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184
Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
KT ++ V SP+G + D LWD ++GK L T G I
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239
Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
+ ++ + + + IW+L+ K IV +L+ VIST+
Sbjct: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELK---QEVISTS 278
Score = 86.7 bits (213), Expect = 3e-17
Identities = 63/214 (29%), Positives = 100/214 (46%), Gaps = 11/214 (5%)
Query: 124 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 177
TLKGH+ +V PQ ++I+S S D+++ +W + G + L HS VS V
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
+ DG +S S+DG R+WD +G + + +S V FS + + I++ + D T
Sbjct: 70 VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128
Query: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQK 296
+KLW+ + G C T + ++ FS IVS D LV +WNL ++
Sbjct: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187
Query: 297 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
GHT + + P ++ AS D LW
Sbjct: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219
Score = 47.4 bits (111), Expect = 2e-05
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 10/109 (9%)
Query: 229 ILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
IL+A+ D T+ +W ++ G + GH + + + + G++ +SGS D +
Sbjct: 31 ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS---SDGQFALSGSWDGTL 87
Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
+W+L T ++ GHT V+S A I S + DKTIKLW +
Sbjct: 88 RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS--RDKTIKLWNT 134
Score = 44.7 bits (104), Expect = 1e-04
Identities = 36/137 (26%), Positives = 61/137 (44%), Gaps = 11/137 (8%)
Query: 34 NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
N LK GHT +++V SP+G AS D +W +GK T+ G + I+ +
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239
Query: 94 AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-------GHSNYVFCCN--FNPQSNLI 144
+S + L +A+ ++KIWD+ + LK + C + ++ +
Sbjct: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Query: 145 VSGSFDESVRIWDVKTG 161
+G D VR+W V G
Sbjct: 299 FAGYTDNLVRVWQVTIG 315
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 123 bits (309), Expect = 2e-28
Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%)
Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
HT AV FS +G+ +AS ADK ++++ A G+ I H+ + A+S+D +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161
+ S DK +KIW+ +G+ + T HS V CC+F S+ L+ +GS D +++WD+
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213
+C T+ H++ V+ F+ D L+ S S DG ++WD S K++ ++D
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793
Query: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267
+ + +S +G I+ A N + L+D ++ G + +TGH + +YC +FS
Sbjct: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 849
Query: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327
+V+ S+ V +WN ++ V +GH V P + +++ +D+TI
Sbjct: 850 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 906
Query: 328 KLWKS 332
+LW++
Sbjct: 907 RLWET 911
Score = 103 bits (258), Expect = 2e-22
Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%)
Query: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
H + +S D + S DKTL+++ +G+ L +K H + V CC F+ I
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203
+ S D+ V+IW+ TG+ + T HS+ V+ HF L+ + S D ++WD
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733
Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253
+C T+ N V+ +FSP+ K + + + D TLKLWD + K+
Sbjct: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792
Query: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
E ++S G + +V+ N ++++++ T ++ ++ I
Sbjct: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 850
Query: 313 ENIIASAALENDKTIKLWKSD 333
+N +A AL + ++LW +D
Sbjct: 851 QNHLAVVAL-SQYCVELWNTD 870
Score = 93.6 bits (231), Expect = 2e-19
Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
+ H V FS + ++A+ S DK +KIW + G+ T H ++ +++ S+
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712
Query: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
LL + S D LK+WD++ +C T+ GH+N V C F+P L+ S S D ++++WD
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
Query: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
+ K++ DP V ++ DG+ I+ ++ + + ++D +
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 831
Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265
L + + + + FSP + A ++LW+ + GH + + +
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 889
Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321
FS G ++ S S+D + +W +TK++ + L+ DVV EN + A+
Sbjct: 890 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 940
Query: 322 ENDKTIKL 329
++ + ++L
Sbjct: 941 DHIRRLQL 948
Score = 86.3 bits (212), Expect = 4e-17
Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%)
Query: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92
T+ GHT +V+ +FSP+ + LAS SAD +K+W A K+I+ + L + D
Sbjct: 738 TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797
Query: 93 ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
+WS+D ++ A+ +K +SG + GH + + C+F+PQ++L V
Sbjct: 798 EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 857
Query: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201
V +W+ + + H V V F+ DGS ++SS D R+W+T
Sbjct: 858 ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 917
Query: 202 SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230
S LK +D +N VS SP+ +YI
Sbjct: 918 SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977
Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
+ +++ + + ++ HK + I F+ K ++S S+D + +WN Q
Sbjct: 978 FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1034
Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
+ + L+GH + V +++ + D T+K+W
Sbjct: 1035 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1070
Score = 80.1 bits (196), Expect = 3e-15
Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)
Query: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
L GH + V + N L S S D +K+W G EK H+ + S D+
Sbjct: 1040 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1098
Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
S S DKT KIW L L+GH+ V C F+ S L+ +G + +RIW+V
Sbjct: 1099 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158
Query: 161 GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208
G+ L S+ +A H F+ DG +++S+ G + W+ +G+ +T
Sbjct: 1159 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1212
Score = 73.2 bits (178), Expect = 3e-13
Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)
Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
++ H++ V+ F+ I S D++++++ +TG+ L + AH D V F+ D
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670
Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242
I + S D +IW++ +G+ + T D+ + V+ F+ + ++L AT D LKLWD
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
Query: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
++ +C T GH N +C F+ K + S S D + +W+
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771
Score = 70.1 bits (170), Expect = 3e-12
Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%)
Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
GH + FSP + + +++W GH + V +S D +
Sbjct: 838 GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897
Query: 103 VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131
+++SDD+T+++W+ V + L+ + G +
Sbjct: 898 LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957
Query: 132 ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
V CC +P I G + ++ I ++ + ++ H V + F D
Sbjct: 958 YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017
Query: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
++SSS D ++W+ +C+ + V + N + +L+ + D T+K+W+
Sbjct: 1018 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074
Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
G K + H+ + T S S D IW+ + +L+GH V
Sbjct: 1075 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1131
Query: 306 STACHPTENIIASAALENDKTIKLW 330
+A ++A+ +++ I++W
Sbjct: 1132 CSAFSVDSTLLATG--DDNGEIRIW 1154
Score = 61.6 bits (148), Expect = 9e-10
Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%)
Query: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82
GH V V FSP+G +SS D+ I++W D F++
Sbjct: 880 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939
Query: 83 ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
I+G + +S S + ++ ++I ++ + + ++
Sbjct: 940 VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999
Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
H V+ F ++S S D +++W+ + KC+ L H + V ++ L
Sbjct: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1058
Query: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
+ S S+DG ++W+ +G K + +S S + + + D T K+W +
Sbjct: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1116
Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
L GH C+ + + +G ++ + IWN+ E++
Sbjct: 1117 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162
Score = 57.0 bits (136), Expect = 2e-08
Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)
Query: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102
H V S S + +S+SADK KIW ++D + GH + A+S DS LL
Sbjct: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1142
Query: 103 VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
+ D+ ++IW+VS+G+ L + H +V F+P +++S ++
Sbjct: 1143 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1200
Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
W+V TG+ +T + + +H + D V+ G+ I T
Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1246
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,681,486
Number of Sequences: 37866
Number of extensions: 597517
Number of successful extensions: 6469
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 303
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 1669
Number of HSP's gapped (non-prelim): 1845
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.