Guide to the Human Genome
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Search of human proteins with 16554627

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16554627 WD repeat domain 5 [Homo sapiens]
         (334 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16554629 WD repeat domain 5 [Homo sapiens]                         690   0.0  
gi|16554627 WD repeat domain 5 [Homo sapiens]                         690   0.0  
gi|23199987 WD repeat domain 5B [Homo sapiens]                        587   e-168
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   187   1e-47
gi|32189425 WD repeat domain 69 [Homo sapiens]                        186   2e-47
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   172   5e-43
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...   169   2e-42
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...   169   2e-42
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...   169   2e-42
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ...   156   3e-38
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s...   156   3e-38
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            153   2e-37
gi|26665869 WD repeat domain 51B [Homo sapiens]                       149   3e-36
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    146   3e-35
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ...   145   6e-35
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...   139   3e-33
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]      138   8e-33
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            136   3e-32
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            136   3e-32
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   135   5e-32
gi|113865883 WD repeat domain 38 [Homo sapiens]                       134   1e-31
gi|7706657 cell division cycle 40 homolog [Homo sapiens]              132   3e-31
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           132   3e-31
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   127   2e-29
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...   126   2e-29
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...   126   2e-29
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...   126   2e-29
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   124   2e-28
gi|5174447 guanine nucleotide binding protein (G protein), beta ...   123   2e-28
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...   123   2e-28

>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  690 bits (1780), Expect = 0.0
 Identities = 334/334 (100%), Positives = 334/334 (100%)

Query: 1   MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
           MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
Sbjct: 1   MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60

Query: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
           ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
Sbjct: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120

Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
           CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
Sbjct: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180

Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
           RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240

Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
           WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300

Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334
           TDVVISTACHPTENIIASAALENDKTIKLWKSDC
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  690 bits (1780), Expect = 0.0
 Identities = 334/334 (100%), Positives = 334/334 (100%)

Query: 1   MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
           MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL
Sbjct: 1   MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60

Query: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
           ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK
Sbjct: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120

Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
           CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
Sbjct: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180

Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
           RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL
Sbjct: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240

Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
           WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300

Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334
           TDVVISTACHPTENIIASAALENDKTIKLWKSDC
Sbjct: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 334


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  587 bits (1514), Expect = e-168
 Identities = 284/333 (85%), Positives = 302/333 (90%), Gaps = 4/333 (1%)

Query: 1   MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 60
           MAT+E +     A+AQ   SSSA QSK  P  PNYALK TL GHT+AVSSVKFSPNGEWL
Sbjct: 1   MATKESRD----AKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWL 56

Query: 61  ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 120
           ASSSAD+LI IWGAYDGK+EKT+ GH L ISDVAWSSDS+ LVSASDDKTLK+WDV SGK
Sbjct: 57  ASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGK 116

Query: 121 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 180
           CLKTLKGHSNYVFCCNFNP SNLI+SGSFDE+V+IW+VKTGKCLKTL AHSDPVSAVHFN
Sbjct: 117 CLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFN 176

Query: 181 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 240
             GSLIVS SYDGLCRIWD ASGQCLKTL+DDDNPPVSFVKFSPNGKYIL ATLDNTLKL
Sbjct: 177 CSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL 236

Query: 241 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 300
           WDYS+G+CLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH
Sbjct: 237 WDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 296

Query: 301 TDVVISTACHPTENIIASAALENDKTIKLWKSD 333
           TDVVIS ACHPTEN+IASAALENDKTIKLW S+
Sbjct: 297 TDVVISAACHPTENLIASAALENDKTIKLWMSN 329


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  187 bits (474), Expect = 1e-47
 Identities = 100/313 (31%), Positives = 165/313 (52%), Gaps = 24/313 (7%)

Query: 38  KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
           K+ L+GH   V+ V F P    + S+S D  IK+W    G FE+T+ GH   + D+++  
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160

Query: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
              LL S S D T+K+WD    +C++T+ GH + V      P  + IVS S D+++++W+
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220

Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN--- 214
           V+TG C+KT   H + V  V  N+DG+LI S S D   R+W  A+ +C   L + ++   
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280

Query: 215 -----PPVSFVKFS-----------PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258
                P  S+   S             G ++L+ + D T+K+WD S G CL T  GH N 
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340

Query: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
              +  +   +GGK+I+S ++D  + +W+ + K  ++ L  H   V S   H T   + +
Sbjct: 341 VRGVLFH---SGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVT 397

Query: 319 AALENDKTIKLWK 331
            ++  D+T+K+W+
Sbjct: 398 GSV--DQTVKVWE 408



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 36/103 (34%), Positives = 62/103 (60%)

Query: 57  GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
           G +L S S DK IK+W    G    T+ GH   +  V + S    ++S +DDKTL++WD 
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367

Query: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
            + +C+KTL  H ++V   +F+  +  +V+GS D++V++W+ +
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  186 bits (473), Expect = 2e-47
 Identities = 100/293 (34%), Positives = 161/293 (54%), Gaps = 7/293 (2%)

Query: 40  TLAGHTKAVSSVKFS-PNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
           TL GH   V ++ F+ P G+ +A+ S DK  K+W    GK   T  GH   I  ++++  
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188

Query: 99  SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
           S L+ + S D T K+WD+ +G+ + TL+GHS  +   +FN   + I++GSFD +V +WD 
Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDA 248

Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
            TG+ +  L  H   +S+  FN D SLI++ S D  C++WD  +G+C+ TL   D+  + 
Sbjct: 249 DTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILD 308

Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
              F   GK I  A+ D T +++  +  KC+    GH+ E   I  N     G  +++GS
Sbjct: 309 SC-FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFN---PQGNHLLTGS 364

Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
            D    IW+ QT + +Q L+GHTD + S A +   NI+ + +   D T ++W+
Sbjct: 365 SDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGS--KDNTCRIWR 415



 Score =  175 bits (443), Expect = 6e-44
 Identities = 91/291 (31%), Positives = 161/291 (55%), Gaps = 7/291 (2%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD-S 99
           L  H   +++V  + +G    + S D+  K+W    G+   T+ GH+  +  +A+++   
Sbjct: 88  LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYG 147

Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159
           + + + S DKT K+W V +GKC  T +GH+  + C +FNPQS L+ +GS D + ++WD++
Sbjct: 148 DKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ 207

Query: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219
            G+ + TL  HS  + ++ FN  G  I++ S+D    +WD  +G+ +  LI      +S 
Sbjct: 208 NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI-GHCAEISS 266

Query: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 279
             F+ +   IL  ++D T KLWD + GKC+ T TGH +E   + + F  T GK I + S 
Sbjct: 267 ASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDE--ILDSCFDYT-GKLIATASA 323

Query: 280 DNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
           D    I++  T++ + KL+GH   +   + +P  N + + +  +DKT ++W
Sbjct: 324 DGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGS--SDKTARIW 372



 Score =  136 bits (343), Expect = 2e-32
 Identities = 72/229 (31%), Positives = 120/229 (52%), Gaps = 5/229 (2%)

Query: 17  PTPSSSATQSKPTPVK----PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
           P  +  AT S  T  K     N    +TL GH+  + S+ F+ +G+ + + S D  + +W
Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246

Query: 73  GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132
            A  G+    + GH   IS  +++ D +L+++ S DKT K+WD ++GKC+ TL GH + +
Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306

Query: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 192
               F+    LI + S D + RI+   T KC+  L  H   +S + FN  G+ +++ S D
Sbjct: 307 LDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSD 366

Query: 193 GLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
              RIWD  +GQCL+ L +     +    F+  G  ++  + DNT ++W
Sbjct: 367 KTARIWDAQTGQCLQVL-EGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score =  105 bits (262), Expect = 6e-23
 Identities = 58/169 (34%), Positives = 88/169 (52%), Gaps = 5/169 (2%)

Query: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224
           K L AH  P++ V  N+ GS  ++ SYD  C++WDTASG+ L TL    N   +    +P
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 225 NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 284
            G  I   + D T KLW    GKC  T+ GH  E  C+  N   T    + +GS D    
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQST---LVATGSMDTTAK 202

Query: 285 IWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
           +W++Q  E V  L+GH+  +IS + + + + I + +   D T+ +W +D
Sbjct: 203 LWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF--DHTVVVWDAD 249


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  172 bits (435), Expect = 5e-43
 Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%)

Query: 12  AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71
           A + Q TP +   Q+ P       A    L+GH   V   KF PNG  LAS+  D+LI +
Sbjct: 34  AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92

Query: 72  WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
           W  Y D     T+ GH   + ++ +++D ++L SAS DKT+ +WD  +G+ +K LKGH++
Sbjct: 93  WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152

Query: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187
           +V  C      PQ  L+ +GS D +V++WD++    ++T   ++  V AV FN     I+
Sbjct: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII 209

Query: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244
           S   D   ++WD    +   T+    +  V+ +  S  G Y+L+  +DNT+++WD     
Sbjct: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268

Query: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301
            K +C+K + G  H  EK  +  ++S  G K I +GS D  VY+W+  ++ I+ KL GH 
Sbjct: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327

Query: 302 DVVISTACHPTENIIASAA 320
             +   A HP E II SA+
Sbjct: 328 GSINEVAFHPDEPIIISAS 346



 Score =  109 bits (273), Expect = 3e-24
 Identities = 61/208 (29%), Positives = 107/208 (51%), Gaps = 9/208 (4%)

Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD 182
           L GH   V+CC F+P  + + S  FD  + +W+V  G C    TL  HS  V  +H+N D
Sbjct: 62  LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120

Query: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
           GS++ S+S D    +WD+ +G+ +K L    +   S        + +   + D T+KLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180

Query: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302
             K   ++T+   +N    +   F+ T  + I+SG  DN + +W+L+  ++   ++GH D
Sbjct: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236

Query: 303 VVISTACHPTENIIASAALENDKTIKLW 330
            V   +     + + S A++N  T+++W
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score =  169 bits (429), Expect = 2e-42
 Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)

Query: 57  GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
           G  + S S D  +K+W A  GK  +T+ GH  G+    WSS    N+++S S D+TLK+W
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 328

Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
           +  +G+C+ TL GH++ V C + + +   +VSGS D ++R+WD++TG+CL  L  H   V
Sbjct: 329 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 386

Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
             V +  DG  +VS +YD + ++WD  +  CL TL    N   S ++F  +G ++++ +L
Sbjct: 387 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 441

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
           D ++++WD   G C+ T TGH+          S+T G       +VSG+ D+ V IW+++
Sbjct: 442 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 491

Query: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
           T + +Q LQG   H   V  T     +N + +++  +D T+KLW
Sbjct: 492 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 531



 Score =  143 bits (360), Expect = 2e-34
 Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 17/259 (6%)

Query: 72  WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
           W   + K  K + GH   +         N +VS SDD TLK+W   +GKCL+TL GH+  
Sbjct: 247 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 305

Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
           V+      + N+I+SGS D ++++W+ +TG+C+ TL  H+  V  +H +     +VS S 
Sbjct: 306 VWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSR 361

Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
           D   R+WD  +GQCL  L+      V  V++  +G+ +++   D  +K+WD     CL T
Sbjct: 362 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 418

Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
             GH N  Y +  +     G  +VSGS D  + +W+++T   +  L GH    +++    
Sbjct: 419 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 471

Query: 312 TENIIASAALENDKTIKLW 330
            +NI+ S     D T+K+W
Sbjct: 472 KDNILVSG--NADSTVKIW 488



 Score =  107 bits (267), Expect = 1e-23
 Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           L GH  AV  V++  +G  + S + D ++K+W         T+ GH   +  + +  D  
Sbjct: 379 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 434

Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
            +VS S D ++++WDV +G C+ TL GH +         + N++VSG+ D +V+IWD+KT
Sbjct: 435 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 492

Query: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
           G+CL+TL     H   V+ + FN+  + +++SS DG  ++WD  +G+ ++ L+
Sbjct: 493 GQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLV 543


>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score =  169 bits (429), Expect = 2e-42
 Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)

Query: 57  GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
           G  + S S D  +K+W A  GK  +T+ GH  G+    WSS    N+++S S D+TLK+W
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 446

Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
           +  +G+C+ TL GH++ V C + + +   +VSGS D ++R+WD++TG+CL  L  H   V
Sbjct: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504

Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
             V +  DG  +VS +YD + ++WD  +  CL TL    N   S ++F  +G ++++ +L
Sbjct: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 559

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
           D ++++WD   G C+ T TGH+          S+T G       +VSG+ D+ V IW+++
Sbjct: 560 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 609

Query: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
           T + +Q LQG   H   V  T     +N + +++  +D T+KLW
Sbjct: 610 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 649



 Score =  143 bits (360), Expect = 2e-34
 Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 17/259 (6%)

Query: 72  WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
           W   + K  K + GH   +         N +VS SDD TLK+W   +GKCL+TL GH+  
Sbjct: 365 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423

Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
           V+      + N+I+SGS D ++++W+ +TG+C+ TL  H+  V  +H +     +VS S 
Sbjct: 424 VWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSR 479

Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
           D   R+WD  +GQCL  L+      V  V++  +G+ +++   D  +K+WD     CL T
Sbjct: 480 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536

Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
             GH N  Y +  +     G  +VSGS D  + +W+++T   +  L GH    +++    
Sbjct: 537 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 589

Query: 312 TENIIASAALENDKTIKLW 330
            +NI+ S     D T+K+W
Sbjct: 590 KDNILVSG--NADSTVKIW 606



 Score =  107 bits (267), Expect = 1e-23
 Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           L GH  AV  V++  +G  + S + D ++K+W         T+ GH   +  + +  D  
Sbjct: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552

Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
            +VS S D ++++WDV +G C+ TL GH +         + N++VSG+ D +V+IWD+KT
Sbjct: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610

Query: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
           G+CL+TL     H   V+ + FN+  + +++SS DG  ++WD  +G+ ++ L+
Sbjct: 611 GQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLV 661


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score =  169 bits (429), Expect = 2e-42
 Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)

Query: 57  GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114
           G  + S S D  +K+W A  GK  +T+ GH  G+    WSS    N+++S S D+TLK+W
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 366

Query: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174
           +  +G+C+ TL GH++ V C + + +   +VSGS D ++R+WD++TG+CL  L  H   V
Sbjct: 367 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 424

Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
             V +  DG  +VS +YD + ++WD  +  CL TL    N   S ++F  +G ++++ +L
Sbjct: 425 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 479

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289
           D ++++WD   G C+ T TGH+          S+T G       +VSG+ D+ V IW+++
Sbjct: 480 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 529

Query: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330
           T + +Q LQG   H   V  T     +N + +++  +D T+KLW
Sbjct: 530 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 569



 Score =  143 bits (360), Expect = 2e-34
 Identities = 83/259 (32%), Positives = 135/259 (52%), Gaps = 17/259 (6%)

Query: 72  WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY 131
           W   + K  K + GH   +         N +VS SDD TLK+W   +GKCL+TL GH+  
Sbjct: 285 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 343

Query: 132 VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSY 191
           V+      + N+I+SGS D ++++W+ +TG+C+ TL  H+  V  +H +     +VS S 
Sbjct: 344 VWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSR 399

Query: 192 DGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 251
           D   R+WD  +GQCL  L+      V  V++  +G+ +++   D  +K+WD     CL T
Sbjct: 400 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 456

Query: 252 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
             GH N  Y +  +     G  +VSGS D  + +W+++T   +  L GH    +++    
Sbjct: 457 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 509

Query: 312 TENIIASAALENDKTIKLW 330
            +NI+ S     D T+K+W
Sbjct: 510 KDNILVSG--NADSTVKIW 526



 Score =  107 bits (267), Expect = 1e-23
 Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           L GH  AV  V++  +G  + S + D ++K+W         T+ GH   +  + +  D  
Sbjct: 417 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 472

Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
            +VS S D ++++WDV +G C+ TL GH +         + N++VSG+ D +V+IWD+KT
Sbjct: 473 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 530

Query: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
           G+CL+TL     H   V+ + FN+  + +++SS DG  ++WD  +G+ ++ L+
Sbjct: 531 GQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRNLV 581


>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score =  156 bits (394), Expect = 3e-38
 Identities = 102/312 (32%), Positives = 165/312 (52%), Gaps = 13/312 (4%)

Query: 25  QSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83
           + KP P + P   LK TL     AV +V+F+ +G +  +  +DK +K+W    G   +T 
Sbjct: 5   EPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63

Query: 84  SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143
           SGH   + D A S D++ L S   DK + +WDV+SG+ ++  +GH+  V    FN ++ +
Sbjct: 64  SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123

Query: 144 IVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
           I+SGS D S+R WD ++ +   ++TL    D VS+V  +     I++ S DG  R +D  
Sbjct: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLR 181

Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
            GQ     +     P++   FS +G+  L ++LD+TL+L D   G+ L  Y GHKN++Y 
Sbjct: 182 MGQLFSDYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238

Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
           +    S      +VS SED  V+ W+L    +   L   + VV S A HPTE  + +A  
Sbjct: 239 LDCCLS-ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAM- 296

Query: 322 ENDKTIKLWKSD 333
               +++ W+ +
Sbjct: 297 --GGSVQCWREE 306


>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
           sapiens]
          Length = 315

 Score =  156 bits (394), Expect = 3e-38
 Identities = 102/312 (32%), Positives = 165/312 (52%), Gaps = 13/312 (4%)

Query: 25  QSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI 83
           + KP P + P   LK TL     AV +V+F+ +G +  +  +DK +K+W    G   +T 
Sbjct: 5   EPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTY 63

Query: 84  SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNL 143
           SGH   + D A S D++ L S   DK + +WDV+SG+ ++  +GH+  V    FN ++ +
Sbjct: 64  SGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATV 123

Query: 144 IVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
           I+SGS D S+R WD ++ +   ++TL    D VS+V  +     I++ S DG  R +D  
Sbjct: 124 ILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVS--DHEILAGSVDGRVRRYDLR 181

Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
            GQ     +     P++   FS +G+  L ++LD+TL+L D   G+ L  Y GHKN++Y 
Sbjct: 182 MGQLFSDYV---GSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYKGHKNQEYK 238

Query: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL 321
           +    S      +VS SED  V+ W+L    +   L   + VV S A HPTE  + +A  
Sbjct: 239 LDCCLS-ERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTAM- 296

Query: 322 ENDKTIKLWKSD 333
               +++ W+ +
Sbjct: 297 --GGSVQCWREE 306


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  153 bits (386), Expect = 2e-37
 Identities = 90/252 (35%), Positives = 139/252 (55%), Gaps = 8/252 (3%)

Query: 36  ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVA 94
           A +FT  GH  AV+ V FSP+G  LAS S DK ++IW   + K E T+   H   +  V 
Sbjct: 16  AYRFT--GHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVH 72

Query: 95  WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
           + SD    V+ASDDKT+K+W     K L +L  H N+V C  F+P   LIVS S D++V+
Sbjct: 73  FCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVK 132

Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
           +WD  + +C+ +   H   V+ V F+  G+ I ++  D   ++WD  + + L+      +
Sbjct: 133 LWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-YQLHS 191

Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
             V+ + F P+G Y++ A+ D+TLK+ D  +G+ L T  GH+     +   FS T G++ 
Sbjct: 192 AAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTV--AFSRT-GEYF 248

Query: 275 VSGSEDNLVYIW 286
            SG  D  V +W
Sbjct: 249 ASGGSDEQVMVW 260



 Score =  117 bits (292), Expect = 2e-26
 Identities = 76/268 (28%), Positives = 130/268 (48%), Gaps = 6/268 (2%)

Query: 66  DKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
           D  + +W           +GHK  ++ V +S   +LL S S DKT++IW  +        
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 126 KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
           + H+  V   +F       V+ S D++V++W     K L +L  H + V    F+ DG L
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 186 IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
           IVS+S D   ++WD +S +C+ +  +     V++V F P+G  I AA +DNT+K+WD   
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180

Query: 246 GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
            + L+ Y  H      +  + S   G ++++ S D+ + I +L    ++  L GH     
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPS---GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPAT 237

Query: 306 STACHPTENIIASAALENDKTIKLWKSD 333
           + A   T    AS    +D+ + +WKS+
Sbjct: 238 TVAFSRTGEYFASGG--SDEQVMVWKSN 263



 Score = 45.1 bits (105), Expect = 9e-05
 Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 7/98 (7%)

Query: 234 LDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI 293
           +D+ L +W          +TGHK+   C+  NFS   G  + SGS D  V IW    K  
Sbjct: 1   MDSCLMVWHMKPQSRAYRFTGHKDAVTCV--NFS-PSGHLLASGSRDKTVRIWVPNVKGE 57

Query: 294 VQKLQGHTDVVIST-ACHPTENIIASAALENDKTIKLW 330
               + HT  V S   C   ++ + ++   +DKT+K+W
Sbjct: 58  STVFRAHTATVRSVHFCSDGQSFVTAS---DDKTVKVW 92


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  149 bits (377), Expect = 3e-36
 Identities = 90/291 (30%), Positives = 145/291 (49%), Gaps = 6/291 (2%)

Query: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
           GH  A++S+  SPNG+ LA++S D  + +W            GHK  ++ V +S   NLL
Sbjct: 16  GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75

Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
            SAS D+T+++W           K H+  V   +F+     + + S D+S+++W +   +
Sbjct: 76  ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135

Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 222
            L +L  H+  V    F+ DG LIVS S D   +IWDT + QC+     D     +FV F
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNN-FSDSVGFANFVDF 194

Query: 223 SPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
           +P+G  I +A  D T+K+WD    K L+ Y  H     CI  + S   G ++++ S D  
Sbjct: 195 NPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPS---GNYLITASSDGT 251

Query: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
           + I +L    ++  LQGHT  V + +      + AS     D  + LW+++
Sbjct: 252 LKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA--DTQVLLWRTN 300



 Score =  147 bits (372), Expect = 1e-35
 Identities = 82/260 (31%), Positives = 138/260 (53%), Gaps = 6/260 (2%)

Query: 35  YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-GAYDGKFEKTISGHKLGISDV 93
           +A  +   GH   V+SV+FSP+G  LAS+S D+ +++W     GKF +    H   +  V
Sbjct: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE-FKAHTAPVRSV 108

Query: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESV 153
            +S+D   L +AS+DK++K+W +   + L +L  H+++V C  F+P   LIVS S D+++
Sbjct: 109 DFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTI 168

Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
           +IWD    +C+          + V FN  G+ I S+  D   ++WD    + L+      
Sbjct: 169 KIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH-YQVH 227

Query: 214 NPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW 273
           +  V+ + F P+G Y++ A+ D TLK+ D  +G+ + T  GH    + +  +FS  GG+ 
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV--SFS-KGGEL 284

Query: 274 IVSGSEDNLVYIWNLQTKEI 293
             SG  D  V +W     E+
Sbjct: 285 FASGGADTQVLLWRTNFDEL 304



 Score =  118 bits (295), Expect = 8e-27
 Identities = 74/255 (29%), Positives = 129/255 (50%), Gaps = 8/255 (3%)

Query: 76  DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
           D   E+   GHK  I+ +  S +   L +AS D  L +W+           GH + V   
Sbjct: 7   DPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSV 66

Query: 136 NFNPQSNLIVSGSFDESVRIW-DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
            F+P  NL+ S S D +VR+W   K GK      AH+ PV +V F+ DG  + ++S D  
Sbjct: 67  QFSPHGNLLASASRDRTVRLWIPDKRGK-FSEFKAHTAPVRSVDFSADGQFLATASEDKS 125

Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
            ++W     + L +L    +  V   KFSP+G+ I++ + D T+K+WD +  +C+  ++ 
Sbjct: 126 IKVWSMYRQRFLYSLYRHTH-WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS- 183

Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
             +  +  F +F+   G  I S   D  V +W+++  +++Q  Q H+  V   + HP+ N
Sbjct: 184 -DSVGFANFVDFN-PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241

Query: 315 IIASAALENDKTIKL 329
            + +A+  +D T+K+
Sbjct: 242 YLITAS--SDGTLKI 254


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  146 bits (368), Expect = 3e-35
 Identities = 86/292 (29%), Positives = 147/292 (50%), Gaps = 17/292 (5%)

Query: 39  FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
           +T     + +++V  + +   +A   AD  +++W     K           +  V  +SD
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKK-----------LRSVKQASD 512

Query: 99  SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
            +L+   SDD   +I D  +   LK L GHS  V+  +F+P  N ++S S D +VR+W +
Sbjct: 513 LSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572

Query: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
           +T  CL     H+ PV    F+  G   VS  +D + R+W T   Q L+ +       V+
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR-IFAGHLADVN 631

Query: 219 FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGS 278
             +F PN  Y+   + D T++LWD   G C++ +TGHK   + +   FS   G+++ +G+
Sbjct: 632 CTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL--TFS-PNGRFLATGA 688

Query: 279 EDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
            D  V +W++    +V +L+GHTD V S        I+AS +++N  T++LW
Sbjct: 689 TDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDN--TVRLW 738



 Score =  122 bits (305), Expect = 6e-28
 Identities = 66/223 (29%), Positives = 106/223 (47%), Gaps = 7/223 (3%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           L GH+  V    FSP+  +L SSS D  +++W            GH   + D  +S    
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598

Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
             VS   D+  ++W     + L+   GH   V C  F+P SN + +GS D +VR+WDV  
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658

Query: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
           G C++    H  P+ ++ F+ +G  + + + DG   +WD   G  +  L       V  +
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL-KGHTDTVCSL 717

Query: 221 KFSPNGKYILAATLDNTLKLWDYSKG------KCLKTYTGHKN 257
           +FS +G+ + + ++DNT++LWD  K           T TGH N
Sbjct: 718 RFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHIN 760



 Score =  115 bits (289), Expect = 4e-26
 Identities = 68/242 (28%), Positives = 115/242 (47%), Gaps = 4/242 (1%)

Query: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
           K + SVK + +   +   S D L +I         K + GH   +   ++S D N L+S+
Sbjct: 502 KKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSS 561

Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
           S+D T+++W + +  CL   KGH+  V+   F+P     VSG  D   R+W     + L+
Sbjct: 562 SEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLR 621

Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
               H   V+   F+ + + + + S D   R+WD  +G C++ +      P+  + FSPN
Sbjct: 622 IFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVR-IFTGHKGPIHSLTFSPN 680

Query: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285
           G+++     D  + LWD   G  +    GH +    +   FS   G+ + SGS DN V +
Sbjct: 681 GRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSL--RFS-RDGEILASGSMDNTVRL 737

Query: 286 WN 287
           W+
Sbjct: 738 WD 739



 Score =  109 bits (272), Expect = 4e-24
 Identities = 53/192 (27%), Positives = 95/192 (49%), Gaps = 3/192 (1%)

Query: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
           GH   V   +FSP G +  S   D++ ++W     +  +  +GH   ++   +  +SN +
Sbjct: 583 GHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYV 642

Query: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK 162
            + S D+T+++WDV +G C++   GH   +    F+P    + +G+ D  V +WD+  G 
Sbjct: 643 ATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL 702

Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG-QCLKTLIDDDNPPVSFVK 221
            +  L  H+D V ++ F+RDG ++ S S D   R+WD     + L+T  DD       + 
Sbjct: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLET--DDFTTATGHIN 760

Query: 222 FSPNGKYILAAT 233
              N + +L  T
Sbjct: 761 LPENSQELLLGT 772



 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 49/174 (28%), Positives = 86/174 (49%), Gaps = 24/174 (13%)

Query: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101
           AGH   V+  +F PN  ++A+ SAD+ +++W   +G   +  +GHK  I  + +S +   
Sbjct: 624 AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRF 683

Query: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD-VKT 160
           L + + D  + +WD+  G  +  LKGH++ V    F+    ++ SGS D +VR+WD +K 
Sbjct: 684 LATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKA 743

Query: 161 GKCLKT-----------LPAHSD------------PVSAVHFNRDGSLIVSSSY 191
            + L+T           LP +S             PV  +HF R   ++ + +Y
Sbjct: 744 FEDLETDDFTTATGHINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVLAAGAY 797



 Score = 68.2 bits (165), Expect = 1e-11
 Identities = 50/198 (25%), Positives = 79/198 (39%), Gaps = 35/198 (17%)

Query: 163 CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW-------------------DTASG 203
           C  T       ++AV    D SLI     D   R+W                   D  S 
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521

Query: 204 QCLKTLIDD-----------DNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
             L+ ++D+            + PV    FSP+  Y+L+++ D T++LW      CL  Y
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581

Query: 253 TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
            GH    Y ++       G + VSG  D +  +W     + ++   GH   V  T  HP 
Sbjct: 582 KGH---NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPN 638

Query: 313 ENIIASAALENDKTIKLW 330
            N +A+ +   D+T++LW
Sbjct: 639 SNYVATGSA--DRTVRLW 654


>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
           sapiens]
          Length = 513

 Score =  145 bits (365), Expect = 6e-35
 Identities = 90/317 (28%), Positives = 157/317 (49%), Gaps = 21/317 (6%)

Query: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL- 88
           P + +  +KF    H   V   +FSP+G++L + S D  I++W    GK  K +      
Sbjct: 202 PTQLSRHIKFGQKSH---VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 258

Query: 89  -------GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQ 140
                   +  + +S D+ +L + + D  +K+W + SG+CL+   + HS  V C +F+  
Sbjct: 259 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 318

Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
           S+ I+S SFD+++RI  +K+GK LK    HS  V+   F +DG  I+S+S DG  +IW+ 
Sbjct: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378

Query: 201 ASGQCLKTL------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
            + +C  T          D    S +    N ++ +     NT+ + +  +G+ +++++ 
Sbjct: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSS 437

Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
            K E            G+WI    ED ++Y ++  T ++ + L  H   VI  A HP +N
Sbjct: 438 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN 497

Query: 315 IIASAALENDKTIKLWK 331
           +IA+     D  +KLWK
Sbjct: 498 LIAT--YSEDGLLKLWK 512


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score =  139 bits (351), Expect = 3e-33
 Identities = 90/327 (27%), Positives = 159/327 (48%), Gaps = 22/327 (6%)

Query: 21  SSATQSKPTPVKPN------YALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
           +SA  +K  P  P       + L   ++GH   V  +   P  +W  + SAD+ IKIW  
Sbjct: 174 NSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL 233

Query: 75  YDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC 134
             GK + +++GH   +  V  S+ S  L S  +DK +K WD+   K ++   GH + V+ 
Sbjct: 234 ASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYG 293

Query: 135 CNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGL 194
            + +P  +++V+ S D + RIWDV+T   + TL  H++ V+ V        I++ S+D  
Sbjct: 294 LDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTT 353

Query: 195 CRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
            R+WD  +G+   TL  +    V  V   P   Y  A+   + +K W +  G  ++  +G
Sbjct: 354 IRLWDLVAGKTRVTL-TNHKKSVRAVVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSG 411

Query: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-----GHTDV---VIS 306
           H      I    +V     +VSG+++  +++W+ +T    Q++      G  D    + +
Sbjct: 412 HN----AIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFA 467

Query: 307 TACHPTENIIASAALENDKTIKLWKSD 333
            A   +E+ + +A  E DKTIK+++ D
Sbjct: 468 CAFDQSESRLLTA--EADKTIKVYRED 492


>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
          Length = 631

 Score =  138 bits (347), Expect = 8e-33
 Identities = 89/315 (28%), Positives = 152/315 (48%), Gaps = 7/315 (2%)

Query: 16  QPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAY 75
           QP P+ + ++   +P K +Y LK     H   VS V   P+ + L S   D+L K+ G  
Sbjct: 323 QPNPNLNVSKESLSPAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLP 382

Query: 76  DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCC 135
                 T  GH   +SD  +    + L ++S D T+K+WD+  G C+ T +GHS  V+ C
Sbjct: 383 KCNVLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSC 442

Query: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
            ++   N + S S D++ +IWDV + +C  TL  H+D V+++ F    + +++SS D   
Sbjct: 443 TWHSCGNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502

Query: 196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGH 255
            IWD  +G C ++L    +  ++   F P G  I +       KLWD+   K L   +  
Sbjct: 503 SIWDARTGICEQSLYGHMH-SINDAIFDPRGHMIASCDACGVTKLWDFR--KLLPIVSID 559

Query: 256 KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
                    NF  + G+ +   S + ++++ +L++ EI  KL GH +   +        I
Sbjct: 560 IGPSPGNEVNFD-SSGRVLAQASGNGVIHLLDLKSGEI-HKLMGHENEAHTVVFSHDGEI 617

Query: 316 IASAALENDKTIKLW 330
           + S    +D T++ W
Sbjct: 618 LFSGG--SDGTVRTW 630


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  136 bits (342), Expect = 3e-32
 Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)

Query: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89
           P   + +L+    GH  AV+ V FS N + LAS S D  + +W           +GHK  
Sbjct: 4   PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63

Query: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
           ++ V +S   +LL S S DKT++IW  +        + H+  V   +F       V+ S 
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123

Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
           D++V++W     K L +L  H + V    F+ DG LIVS+S D   ++WD +S +C+ + 
Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183

Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
            +     V++V F P+G  I AA +DNT+K+WD    + L+ Y  H      +  + S  
Sbjct: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240

Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
            G ++++ S D+ + I +L    ++  L GH     + A   T    AS    +D+ + +
Sbjct: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297

Query: 330 WKSD 333
           WKS+
Sbjct: 298 WKSN 301


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  136 bits (342), Expect = 3e-32
 Identities = 90/304 (29%), Positives = 149/304 (49%), Gaps = 6/304 (1%)

Query: 30  PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLG 89
           P   + +L+    GH  AV+ V FS N + LAS S D  + +W           +GHK  
Sbjct: 4   PCAEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDA 63

Query: 90  ISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSF 149
           ++ V +S   +LL S S DKT++IW  +        + H+  V   +F       V+ S 
Sbjct: 64  VTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASD 123

Query: 150 DESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL 209
           D++V++W     K L +L  H + V    F+ DG LIVS+S D   ++WD +S +C+ + 
Sbjct: 124 DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSY 183

Query: 210 IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVT 269
            +     V++V F P+G  I AA +DNT+K+WD    + L+ Y  H      +  + S  
Sbjct: 184 CEHGG-FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPS-- 240

Query: 270 GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKL 329
            G ++++ S D+ + I +L    ++  L GH     + A   T    AS    +D+ + +
Sbjct: 241 -GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG--SDEQVMV 297

Query: 330 WKSD 333
           WKS+
Sbjct: 298 WKSN 301


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  135 bits (340), Expect = 5e-32
 Identities = 79/299 (26%), Positives = 143/299 (47%), Gaps = 13/299 (4%)

Query: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL- 101
           G  + +S   FSPN + LA++    L K+W   D     T+ GH   +  + +   S + 
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS 288

Query: 102 -------LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
                  L S + D ++K+W + S + +  ++GH+  V    ++P    + +  +D S R
Sbjct: 289 LDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWR 348

Query: 155 IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDN 214
           +WD++  + +     HS  V  + F++DGSL  +   D   R+WD  +G+C+   ++   
Sbjct: 349 LWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCI-MFLEGHL 407

Query: 215 PPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWI 274
             +  + FSPNG +I   + DNT K+WD  + +C+ T   H+N        F    G ++
Sbjct: 408 KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQN--LVTGVKFEPIHGNFL 465

Query: 275 VSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSD 333
           ++G+ DN   IW       ++ L GH   V+         +IA+ +   D+T KLW ++
Sbjct: 466 LTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSY--DRTFKLWMAE 522



 Score =  126 bits (317), Expect = 2e-29
 Identities = 74/263 (28%), Positives = 127/263 (48%), Gaps = 13/263 (4%)

Query: 33  PNYALKFTLAGHTKAVSSVKFSPNGEW--------LASSSADKLIKIWGAYDGKFEKTIS 84
           P+  L  TL GH   V ++ F P            LAS +AD  +K+W     +    I 
Sbjct: 261 PDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIE 320

Query: 85  GHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144
           GH + ++ V W      L +   D++ ++WD+ + + +   +GHS  V+   F+   +L 
Sbjct: 321 GHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLA 380

Query: 145 VSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ 204
            +G  D   R+WD++TG+C+  L  H   +  ++F+ +G  I + S D  C++WD    +
Sbjct: 381 GTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRR 440

Query: 205 CLKTLIDDDNPPVSFVKFSP-NGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIF 263
           C+ T+    N  V+ VKF P +G ++L    DNT K+W +     LKT  GH+ +   + 
Sbjct: 441 CVYTIPAHQN-LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGK---VM 496

Query: 264 ANFSVTGGKWIVSGSEDNLVYIW 286
                + G+ I + S D    +W
Sbjct: 497 GLDISSDGQLIATCSYDRTFKLW 519



 Score = 32.3 bits (72), Expect = 0.61
 Identities = 15/42 (35%), Positives = 24/42 (57%)

Query: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA 74
           P ++   TLAGH   V  +  S +G+ +A+ S D+  K+W A
Sbjct: 480 PGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMA 521


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  134 bits (337), Expect = 1e-31
 Identities = 79/285 (27%), Positives = 139/285 (48%), Gaps = 8/285 (2%)

Query: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
           H   V+S  FSP+G+ L + S D  +  W    G+    + GH   +    +S D +L  
Sbjct: 20  HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFA 79

Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC 163
           SAS D T+++WDV+  KCL+ LKGH   V   +F+P S  + SG +D+ V +WDV++G+ 
Sbjct: 80  SASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQM 139

Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD--TASGQCLKTLIDDDNPPVSFVK 221
           L+ L  H D + +  F+   + + + S+D    IWD    +       ++  +  +S + 
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199

Query: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKN-EKYCIFANFSVTGGKWIVSGSED 280
           +S +G  + + + D T+ +W  +    L    GH    K   F+   +    W+ S    
Sbjct: 200 YSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL----WLASAGYS 254

Query: 281 NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325
            +V +W+  T + ++ L+G  DV  + A  P   I+ S A +  +
Sbjct: 255 RMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTR 299



 Score =  133 bits (335), Expect = 2e-31
 Identities = 83/251 (33%), Positives = 130/251 (51%), Gaps = 16/251 (6%)

Query: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
           L + L GHT  V   +FSP+G   AS+S D  +++W     K  + + GH+  +  V++S
Sbjct: 55  LLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 114

Query: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
            DS  L S   DK + +WDV SG+ L+ L GH + +   +F+P  N + +GS+D +V IW
Sbjct: 115 PDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIW 174

Query: 157 D---VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
           D   V      + L  HS  +S + ++  G L+ S S+D    IW   +   L  L    
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQL---- 229

Query: 214 NPPVSFVK---FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY-CIFANFSVT 269
              V++VK   FSP+  ++ +A     +K+WD + GKCL+T  G  +  + C F      
Sbjct: 230 KGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF----TP 285

Query: 270 GGKWIVSGSED 280
            GK +VSG+ D
Sbjct: 286 DGKILVSGAAD 296



 Score =  127 bits (319), Expect = 1e-29
 Identities = 80/257 (31%), Positives = 124/257 (48%), Gaps = 12/257 (4%)

Query: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140
           K    H   ++  A+S D  +L++ S+D  +  W+  SG+ L  L GH+  V  C F+P 
Sbjct: 15  KFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPD 74

Query: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
            +L  S S D +VR+WDV   KCL+ L  H   V  V F+ D   + S  +D    +WD 
Sbjct: 75  GHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134

Query: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD---YSKGKCLKTYTGHKN 257
            SGQ L+ L+      +    FSP    +   + D+T+ +WD    +     +   GH  
Sbjct: 135 QSGQMLRLLV-GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193

Query: 258 EKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317
              C+   +S +G   + SGS D  ++IW   T  ++ +L+GH   V S A  P E  +A
Sbjct: 194 NISCLC--YSASG--LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLA 249

Query: 318 SAALENDKTIKLWKSDC 334
           SA     + +K+W  DC
Sbjct: 250 SAGY--SRMVKVW--DC 262



 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 54/167 (32%), Positives = 92/167 (55%), Gaps = 6/167 (3%)

Query: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
           +K    H   V++  F+ DG ++++ S DG    W+T SGQ L  L      PV F +FS
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL-GGHTGPVKFCRFS 72

Query: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
           P+G    +A+ D T++LWD ++ KCL+   GH+     +  +FS    + + SG  D  V
Sbjct: 73  PDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV--SFS-PDSRQLASGGWDKRV 129

Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
            +W++Q+ ++++ L GH D + S+   PT N +A+ +   D T+ +W
Sbjct: 130 MLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSW--DSTVHIW 174



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 42/114 (36%), Positives = 63/114 (55%), Gaps = 1/114 (0%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           L GH+  +S + +S +G  LAS S DK I IW          + GH   +  +A+S D  
Sbjct: 188 LEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDEL 246

Query: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
            L SA   + +K+WD ++GKCL+TLKG  +    C F P   ++VSG+ D++ R
Sbjct: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 26/75 (34%), Positives = 41/75 (54%)

Query: 36  ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAW 95
           +L   L GH   V S+ FSP+  WLAS+   +++K+W    GK  +T+ G        A+
Sbjct: 224 SLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAF 283

Query: 96  SSDSNLLVSASDDKT 110
           + D  +LVS + D+T
Sbjct: 284 TPDGKILVSGAADQT 298


>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
          Length = 579

 Score =  132 bits (333), Expect = 3e-31
 Identities = 84/299 (28%), Positives = 145/299 (48%), Gaps = 15/299 (5%)

Query: 42  AGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAY-DGKFEKTISGHKLGISDVAWSSDS 99
           +GHTK VS+V+  P +G  L S S D  IK+W  Y + +  +T  GH   + D+ +++  
Sbjct: 285 SGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAG 344

Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNP---QSNLIVSGSFDESVRIW 156
              +SA+ D+ LK+WD  +G+C+          +C  FNP   + NL V+G  D+ +  W
Sbjct: 345 TQFLSAAYDRYLKLWDTETGQCISRFTNRK-VPYCVKFNPDEDKQNLFVAGMSDKKIVQW 403

Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPP 216
           D+++G+ ++    H   V+ + F  +    VS+S D   R+W+       K + +     
Sbjct: 404 DIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS 463

Query: 217 VSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL---KTYTGHKNEKYCIFANFSVTGGKW 273
           +  V  SPNGK++   ++DN + ++       L   K + GH    Y    +FS     +
Sbjct: 464 MPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFS-PDMSY 522

Query: 274 IVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP--TENIIASAALENDKTIKLW 330
           ++SG  +  + IW+ +T ++  + + H  V I    HP  T  +I       D  IKLW
Sbjct: 523 VISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGW---DGLIKLW 578


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  132 bits (333), Expect = 3e-31
 Identities = 89/307 (28%), Positives = 153/307 (49%), Gaps = 32/307 (10%)

Query: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
           +L GH++AV SV FSP G++LAS S D  ++ W         T  GH+  +  ++WS D 
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDG 168

Query: 100 NLLVSASDDKTLKIWDVSSGKCL-KTLKGHSNYVFCCNF-----NPQSNLIVSGSFDESV 153
             L S   +  + +WD S+GK + +TL GHS ++   ++     NP+   + S S D SV
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228

Query: 154 RIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDD 213
           RIWD   G+C + L  H+  V+ + +  DG L+ S+S D   ++W    G   +TL    
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTL---- 283

Query: 214 NPPVSFVKFSPNGKYI--LAATLDNTLKLWDYSKGKCL---KTYTGHKNE-KYCIFANFS 267
                      +G ++  +A + D  L+   +   +     +   G   E K    + ++
Sbjct: 284 ---------QGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYN 334

Query: 268 VTGGKW---IVSGSEDNLVYIWN-LQTKEIVQKLQGHTDVVISTACHPTENIIASAALEN 323
           +  G+    +VSGS+D  +++W+  + K+ + ++ GH  ++      P   I+ASA+   
Sbjct: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF-- 392

Query: 324 DKTIKLW 330
           DK+IKLW
Sbjct: 393 DKSIKLW 399



 Score =  130 bits (326), Expect = 2e-30
 Identities = 89/341 (26%), Positives = 154/341 (45%), Gaps = 54/341 (15%)

Query: 39  FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGK-FEKTISGHKLGISDVAW-- 95
           FT  GH   V S+ +SP+G  LAS   +  I +W    GK   +T++GH   I+ ++W  
Sbjct: 150 FTCKGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209

Query: 96  ---SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152
              + +   + S+S D +++IWD ++G+C + L GH+  V C  +     L+ S S D +
Sbjct: 210 LHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWG-GDGLLYSASQDRT 268

Query: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRD---------------------GSL------ 185
           +++W    G   +TL  H   V+ +  + D                     GSL      
Sbjct: 269 IKVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKER 328

Query: 186 ---------------IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL 230
                          +VS S D    +W  A  +   T +      ++ V FSP+ + + 
Sbjct: 329 ALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVA 388

Query: 231 AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
           +A+ D ++KLWD   GK L +  GH    Y I  +      + +VSGS D+ + +W+++ 
Sbjct: 389 SASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWS---ADSRLLVSGSSDSTLKVWDVKA 445

Query: 291 KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWK 331
           +++   L GH D V +    P    +AS     DK +++W+
Sbjct: 446 QKLAMDLPGHADEVYAVDWSPDGQRVASGG--KDKCLRIWR 484



 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 52/208 (25%), Positives = 100/208 (48%), Gaps = 10/208 (4%)

Query: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHF 179
           +C  +L+GHS  V    F+P    + SGS D +VR WD+ T     T   H   V ++ +
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164

Query: 180 NRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF-----SPNGKYILAATL 234
           + DG  + S   +G   +WD ++G+ +   +   +  ++ + +     +P  +Y+ +++ 
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSK 224

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
           D ++++WD + G+C +  TGH     C+       G   + S S+D  + +W      + 
Sbjct: 225 DGSVRIWDTTAGRCERILTGHTQSVTCL----RWGGDGLLYSASQDRTIKVWRAHDGVLC 280

Query: 295 QKLQGHTDVVISTACHPTENIIASAALE 322
           + LQGH   V +T    T+  + + A E
Sbjct: 281 RTLQGHGHWV-NTMALSTDYALRTGAFE 307



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 48/217 (22%), Positives = 89/217 (41%), Gaps = 29/217 (13%)

Query: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSS------ 190
           F  +   ++   FD  V I   +       L A  DP+    F  D  ++ S        
Sbjct: 21  FQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLGKTLESQ 80

Query: 191 -----------YDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLK 239
                      Y         A  +C  +L +  +  V  V FSP GKY+ + + D T++
Sbjct: 81  AVETEKVLDIIYQPQAIFRVRAVTRCTSSL-EGHSEAVISVAFSPTGKYLASGSGDTTVR 139

Query: 240 LWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT-KEIVQKLQ 298
            WD S      T  GH++  + +  ++S  G K + SG ++  + +W+  T K++ + L 
Sbjct: 140 FWDLSTETPHFTCKGHRH--WVLSISWSPDGRK-LASGCKNGQILLWDPSTGKQVGRTLA 196

Query: 299 GHTDVVISTACHPTE-----NIIASAALENDKTIKLW 330
           GH+  +   +  P         +AS++   D ++++W
Sbjct: 197 GHSKWITGLSWEPLHANPECRYVASSS--KDGSVRIW 231



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 15/36 (41%), Positives = 22/36 (61%)

Query: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
           L   L GH   V +V +SP+G+ +AS   DK ++IW
Sbjct: 448 LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  127 bits (318), Expect = 2e-29
 Identities = 77/263 (29%), Positives = 129/263 (49%), Gaps = 15/263 (5%)

Query: 46  KAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105
           K V+S+ ++  G  LA+ S D   +IW   DG    T+  HK  I  + W+   N ++SA
Sbjct: 226 KDVTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTLGQHKGPIFALKWNKKGNFILSA 284

Query: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165
             DKT  IWD  +G+  +    HS      ++   +N   S S D  + +  +   + +K
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRPIK 343

Query: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225
           T   H++ V+A+ ++  G+L+ S S D   +IW      C+  L    N  +  +K+SP 
Sbjct: 344 TFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDL-QAHNKEIYTIKWSPT 402

Query: 226 GK---------YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS 276
           G           + +A+ D+T++LWD  +G C+ T T H+   Y +  +     G+++ S
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFS---PDGRYLAS 459

Query: 277 GSEDNLVYIWNLQTKEIVQKLQG 299
           GS D  V+IWN QT  +V   +G
Sbjct: 460 GSFDKCVHIWNTQTGALVHSYRG 482



 Score =  123 bits (309), Expect = 2e-28
 Identities = 65/227 (28%), Positives = 114/227 (50%), Gaps = 11/227 (4%)

Query: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
           L  TL  H   + ++K++  G ++ S+  DK   IW A+ G+ ++    H     DV W 
Sbjct: 258 LASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 317

Query: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
           S+ N   S S D  + +  +   + +KT +GH+N V    ++P  NL+ S S D +++IW
Sbjct: 318 SN-NTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW 376

Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGS---------LIVSSSYDGLCRIWDTASGQCLK 207
            +K   C+  L AH+  +  + ++  G          ++ S+S+D   R+WD   G C+ 
Sbjct: 377 SMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIH 436

Query: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
           TL     P  S V FSP+G+Y+ + + D  + +W+   G  + +Y G
Sbjct: 437 TLTKHQEPVYS-VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRG 482



 Score =  104 bits (259), Expect = 1e-22
 Identities = 66/221 (29%), Positives = 113/221 (51%), Gaps = 24/221 (10%)

Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-----------CLKT----LPA 169
           L+GH + VF C +NP S+L+ SGS D + RIW++               C++     +P+
Sbjct: 165 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPS 224

Query: 170 HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYI 229
           + D V+++ +N +G+L+ + SYDG  RIW T  G    TL      P+  +K++  G +I
Sbjct: 225 NKD-VTSLDWNSEGTLLATGSYDGFARIW-TKDGNLASTL-GQHKGPIFALKWNKKGNFI 281

Query: 230 LAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQ 289
           L+A +D T  +WD   G+  + +  H      +    + T      S S D  +++  L 
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT----FASCSTDMCIHVCKLG 337

Query: 290 TKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
               ++  QGHT+ V +    PT N++AS +  +D T+K+W
Sbjct: 338 QDRPIKTFQGHTNEVNAIKWDPTGNLLASCS--DDMTLKIW 376



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 35/128 (27%), Positives = 62/128 (48%), Gaps = 10/128 (7%)

Query: 41  LAGHTKAVSSVKFSPNGE---------WLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
           L  H K + ++K+SP G           LAS+S D  +++W    G    T++ H+  + 
Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVY 446

Query: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
            VA+S D   L S S DK + IW+  +G  + + +G       C +N   + + + + D 
Sbjct: 447 SVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVC-WNAAGDKVGASASDG 505

Query: 152 SVRIWDVK 159
           SV + D++
Sbjct: 506 SVCVLDLR 513



 Score = 48.9 bits (115), Expect = 6e-06
 Identities = 26/77 (33%), Positives = 43/77 (55%), Gaps = 1/77 (1%)

Query: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
           TL  H + V SV FSP+G +LAS S DK + IW    G    +  G   GI +V W++  
Sbjct: 437 TLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTG-GIFEVCWNAAG 495

Query: 100 NLLVSASDDKTLKIWDV 116
           + + +++ D ++ + D+
Sbjct: 496 DKVGASASDGSVCVLDL 512


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score =  126 bits (317), Expect = 2e-29
 Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)

Query: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
           D   ++S   D ++KIWD +S +CLK L GH+  V C  ++ +  +IV+GS D +VR+WD
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 306

Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
           V TG+ L TL  H++ V  +H      L+V+ S D    +WD AS     L+ ++     
Sbjct: 307 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 364

Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
            V+ V F  + KYI++A+ D T+K+W  S  + ++T  GHK    C+         + +V
Sbjct: 365 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 417

Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
           SGS DN + +W+++    ++ L+GH ++V    C   +N  I++ A    D  IK+W
Sbjct: 418 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 468



 Score =  112 bits (280), Expect = 5e-25
 Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)

Query: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
           L+  L GH  AV+ V F  + +++ S+S D+ IK+W     +F +T++GHK GI+ + + 
Sbjct: 355 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 412

Query: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
               L+VS S D T+++WD+  G CL+ L+GH   V C  F+  +  IVSG++D  +++W
Sbjct: 413 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 468

Query: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
           D++            CL+TL  HS  V  + F  D   I+SSS+D    IWD
Sbjct: 469 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 518



 Score =  108 bits (271), Expect = 5e-24
 Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)

Query: 58  EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
           E + S   D  IKIW     +  K ++GH   +  + +  D  ++V+ S D T+++WDV+
Sbjct: 251 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 308

Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
           +G+ L TL  H+  V    F+  + L+V+ S D S+ +WD+ +   +   + L  H   V
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 366

Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
           + V F  D   IVS+S D   ++W T++ + ++TL +     ++ +++    + +++ + 
Sbjct: 367 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 421

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
           DNT++LWD   G CL+   GH+    CI F N      K IVSG+ D  + +W+LQ
Sbjct: 422 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 471


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score =  126 bits (317), Expect = 2e-29
 Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)

Query: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
           D   ++S   D ++KIWD +S +CLK L GH+  V C  ++ +  +IV+GS D +VR+WD
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 272

Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
           V TG+ L TL  H++ V  +H      L+V+ S D    +WD AS     L+ ++     
Sbjct: 273 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 330

Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
            V+ V F  + KYI++A+ D T+K+W  S  + ++T  GHK    C+         + +V
Sbjct: 331 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 383

Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
           SGS DN + +W+++    ++ L+GH ++V    C   +N  I++ A    D  IK+W
Sbjct: 384 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 434



 Score =  112 bits (280), Expect = 5e-25
 Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)

Query: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
           L+  L GH  AV+ V F  + +++ S+S D+ IK+W     +F +T++GHK GI+ + + 
Sbjct: 321 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 378

Query: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
               L+VS S D T+++WD+  G CL+ L+GH   V C  F+  +  IVSG++D  +++W
Sbjct: 379 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 434

Query: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
           D++            CL+TL  HS  V  + F  D   I+SSS+D    IWD
Sbjct: 435 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484



 Score =  108 bits (271), Expect = 5e-24
 Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)

Query: 58  EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
           E + S   D  IKIW     +  K ++GH   +  + +  D  ++V+ S D T+++WDV+
Sbjct: 217 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 274

Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
           +G+ L TL  H+  V    F+  + L+V+ S D S+ +WD+ +   +   + L  H   V
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 332

Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
           + V F  D   IVS+S D   ++W T++ + ++TL +     ++ +++    + +++ + 
Sbjct: 333 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 387

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
           DNT++LWD   G CL+   GH+    CI F N      K IVSG+ D  + +W+LQ
Sbjct: 388 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 437


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score =  126 bits (317), Expect = 2e-29
 Identities = 79/237 (33%), Positives = 130/237 (54%), Gaps = 21/237 (8%)

Query: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
           D   ++S   D ++KIWD +S +CLK L GH+  V C  ++ +  +IV+GS D +VR+WD
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDER--VIVTGSSDSTVRVWD 293

Query: 158 VKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQ--CLKTLIDDDNP 215
           V TG+ L TL  H++ V  +H      L+V+ S D    +WD AS     L+ ++     
Sbjct: 294 VNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRA 351

Query: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275
            V+ V F  + KYI++A+ D T+K+W  S  + ++T  GHK    C+         + +V
Sbjct: 352 AVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR-----DRLVV 404

Query: 276 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN--IIASAALENDKTIKLW 330
           SGS DN + +W+++    ++ L+GH ++V    C   +N  I++ A    D  IK+W
Sbjct: 405 SGSSDNTIRLWDIECGACLRVLEGHEELV---RCIRFDNKRIVSGA---YDGKIKVW 455



 Score =  112 bits (280), Expect = 5e-25
 Identities = 62/172 (36%), Positives = 98/172 (56%), Gaps = 17/172 (9%)

Query: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWS 96
           L+  L GH  AV+ V F  + +++ S+S D+ IK+W     +F +T++GHK GI+ + + 
Sbjct: 342 LRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYR 399

Query: 97  SDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
               L+VS S D T+++WD+  G CL+ L+GH   V C  F+  +  IVSG++D  +++W
Sbjct: 400 D--RLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFD--NKRIVSGAYDGKIKVW 455

Query: 157 DVKTG---------KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
           D++            CL+TL  HS  V  + F  D   I+SSS+D    IWD
Sbjct: 456 DLQAALDPRAPASTLCLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505



 Score =  108 bits (271), Expect = 5e-24
 Identities = 71/236 (30%), Positives = 126/236 (53%), Gaps = 19/236 (8%)

Query: 58  EWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVS 117
           E + S   D  IKIW     +  K ++GH   +  + +  D  ++V+ S D T+++WDV+
Sbjct: 238 EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDSTVRVWDVN 295

Query: 118 SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCL---KTLPAHSDPV 174
           +G+ L TL  H+  V    F+  + L+V+ S D S+ +WD+ +   +   + L  H   V
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAV 353

Query: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234
           + V F  D   IVS+S D   ++W T++ + ++TL +     ++ +++    + +++ + 
Sbjct: 354 NVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTL-NGHKRGIACLQY--RDRLVVSGSS 408

Query: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCI-FANFSVTGGKWIVSGSEDNLVYIWNLQ 289
           DNT++LWD   G CL+   GH+    CI F N      K IVSG+ D  + +W+LQ
Sbjct: 409 DNTIRLWDIECGACLRVLEGHEELVRCIRFDN------KRIVSGAYDGKIKVWDLQ 458


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score =  124 bits (310), Expect = 2e-28
 Identities = 83/300 (27%), Positives = 145/300 (48%), Gaps = 17/300 (5%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH-KLGISDVAWSSDS 99
           L+GH  AVS+  F  +   L S S D  +K+W   DG   +      K  + + + + DS
Sbjct: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157

Query: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG-SFDESVRIWDV 158
           + +++AS DKT++ WD+ +GK L  ++ +  ++  C F+P    +VSG   D  + I D 
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGICIMDA 216

Query: 159 KTGKCLKTLPAH-SDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPV 217
           +    +  +  H +  +++  F+ D   + S S D   +IWD  S   L T+    +  +
Sbjct: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276

Query: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGK------CLKTYTGHKNE-KYCIFANFSVTG 270
           S   F+ +G ++  ++ D  LK+W+   G+      C+    GH+     C FA  S   
Sbjct: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDS--- 333

Query: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
             +++SG  D  V IW++        L+GH D V+  A    +  I SA+   D+T++LW
Sbjct: 334 -SFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSAS--KDRTMRLW 390



 Score =  111 bits (278), Expect = 8e-25
 Identities = 70/204 (34%), Positives = 107/204 (52%), Gaps = 10/204 (4%)

Query: 48  VSSVKFSPNGEWLASS-SADKLIKIWGAYDGKFEKTISGHKL-GISDVAWSSDSNLLVSA 105
           + S KFSP+G+++ S    D  I I  A +      I  H    I+   +  DS  + S 
Sbjct: 189 IVSCKFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASV 248

Query: 106 SDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGK-- 162
           S D+ +KIWDV+S   L T+ K HSN +  C F    + + + S+D++++IW+V TG+  
Sbjct: 249 SLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFR 308

Query: 163 ----CLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS 218
               C+  +  H   VS+ HF RD S ++S  +D    IWD A G   K  +   N  V 
Sbjct: 309 NCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGY-RKLSLKGHNDWVM 367

Query: 219 FVKFSPNGKYILAATLDNTLKLWD 242
            V  S N K+IL+A+ D T++LW+
Sbjct: 368 DVAISNNKKWILSASKDRTMRLWN 391



 Score =  100 bits (249), Expect = 2e-21
 Identities = 56/163 (34%), Positives = 90/163 (55%), Gaps = 7/163 (4%)

Query: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS-GHKLGISDVAWSSDSNLL 102
           HT++++S  F P+ + +AS S D+ IKIW         TI+  H   IS+  ++   + L
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288

Query: 103 VSASDDKTLKIWDVSSGK------CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW 156
            ++S DK LKIW+V +G+      C+  ++GH   V  C+F   S+ ++SG FD +V IW
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348

Query: 157 DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 199
           DV  G    +L  H+D V  V  + +   I+S+S D   R+W+
Sbjct: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391



 Score = 81.6 bits (200), Expect = 9e-16
 Identities = 40/122 (32%), Positives = 72/122 (59%), Gaps = 6/122 (4%)

Query: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKT------ISGHKLGISDVAWSS 97
           H+ A+S+  F+ +G +L +SS DK +KIW  + G+F         + GH+  +S   ++ 
Sbjct: 272 HSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFAR 331

Query: 98  DSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 157
           DS+ L+S   D+T+ IWDV+ G    +LKGH+++V     +     I+S S D ++R+W+
Sbjct: 332 DSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWN 391

Query: 158 VK 159
           ++
Sbjct: 392 IE 393



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 67/261 (25%), Positives = 106/261 (40%), Gaps = 61/261 (23%)

Query: 123 KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAH-SDPVSAVHFNR 181
           K L GH + V  C+F      ++SGS+D +V++WD   G  ++        PV       
Sbjct: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155

Query: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL----------- 230
           D S ++++SYD   R WD  +G+ L  +  D    +   KFSP+GKY++           
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTF--IVSCKFSPDGKYVVSGFDVDHGICI 213

Query: 231 ---------------------------------AATLDNTLKLWDYSKGKCLKTYT-GHK 256
                                            + +LD  +K+WD +    L T T  H 
Sbjct: 214 MDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHS 273

Query: 257 NE-KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEI------VQKLQGHTDVVISTAC 309
           N    C F  FS   G ++ + S D  + IWN+ T E       V  +QGH   V  ++C
Sbjct: 274 NAISNCCF-TFS---GHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV--SSC 327

Query: 310 HPTENIIASAALENDKTIKLW 330
           H   +     +   D+T+ +W
Sbjct: 328 HFARDSSFLISGGFDRTVAIW 348



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 24/76 (31%), Positives = 46/76 (60%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           + GH  +VSS  F+ +  +L S   D+ + IW   +G  + ++ GH   + DVA S++  
Sbjct: 317 MQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKK 376

Query: 101 LLVSASDDKTLKIWDV 116
            ++SAS D+T+++W++
Sbjct: 377 WILSASKDRTMRLWNI 392



 Score = 33.5 bits (75), Expect = 0.27
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 38  KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
           K +L GH   V  V  S N +W+ S+S D+ +++W
Sbjct: 356 KLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLW 390


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score =  123 bits (309), Expect = 2e-28
 Identities = 89/275 (32%), Positives = 141/275 (51%), Gaps = 19/275 (6%)

Query: 27  KPTPVKPNYAL-KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISG 85
           K T  + NY + +  L GH+  VS V  S +G++  S S D  +++W    G   +   G
Sbjct: 44  KLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVG 103

Query: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFNPQSN- 142
           H   +  VA+SSD+  +VS S DKT+K+W+ + G C  T++   HS +V C  F+P S+ 
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSN 162

Query: 143 -LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
            +IVS  +D+ V++W++   K       H+  ++ V  + DGSL  S   DG   +WD  
Sbjct: 163 PIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222

Query: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY-------TG 254
            G+ L TL  D    ++ + FSPN +Y L A    ++K+WD  +GK +          T 
Sbjct: 223 EGKHLYTL--DGGDIINALCFSPN-RYWLCAATGPSIKIWDL-EGKIIVDELKQEVISTS 278

Query: 255 HKNEK-YCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
            K E   C    +S  G + + +G  DNLV +W +
Sbjct: 279 SKAEPPQCTSLAWSADG-QTLFAGYTDNLVRVWQV 312



 Score =  112 bits (281), Expect = 4e-25
 Identities = 86/282 (30%), Positives = 141/282 (50%), Gaps = 20/282 (7%)

Query: 37  LKFTLAGHTKAVSSVKFSPN-GEWLASSSADKLIKIWGAYD-----GKFEKTISGHKLGI 90
           L+ TL GH   V+ +  +P   + + S+S DK I +W         G  ++ + GH   +
Sbjct: 7   LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66

Query: 91  SDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFD 150
           SDV  SSD    +S S D TL++WD+++G   +   GH+  V    F+  +  IVSGS D
Sbjct: 67  SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRD 126

Query: 151 ESVRIWDVKTGKCLKTL--PAHSDPVSAVHF--NRDGSLIVSSSYDGLCRIWDTASGQCL 206
           +++++W+   G C  T+   +HS+ VS V F  N    +IVS  +D L ++W+ A+ + L
Sbjct: 127 KTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCK-L 184

Query: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
           KT        ++ V  SP+G    +   D    LWD ++GK L T  G       I    
Sbjct: 185 KTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGD-----IINAL 239

Query: 267 SVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTA 308
             +  ++ +  +    + IW+L+ K IV +L+     VIST+
Sbjct: 240 CFSPNRYWLCAATGPSIKIWDLEGKIIVDELK---QEVISTS 278



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 63/214 (29%), Positives = 100/214 (46%), Gaps = 11/214 (5%)

Query: 124 TLKGHSNYVFCCNFNPQ-SNLIVSGSFDESVRIW-----DVKTGKCLKTLPAHSDPVSAV 177
           TLKGH+ +V      PQ  ++I+S S D+++ +W     +   G   + L  HS  VS V
Sbjct: 10  TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69

Query: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT 237
             + DG   +S S+DG  R+WD  +G   +  +      +S V FS + + I++ + D T
Sbjct: 70  VISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLS-VAFSSDNRQIVSGSRDKT 128

Query: 238 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGK-WIVSGSEDNLVYIWNLQTKEIVQK 296
           +KLW+ + G C  T     + ++     FS       IVS   D LV +WNL   ++   
Sbjct: 129 IKLWN-TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTN 187

Query: 297 LQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
             GHT  + +    P  ++ AS     D    LW
Sbjct: 188 HIGHTGYLNTVTVSPDGSLCASGG--KDGQAMLW 219



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 10/109 (9%)

Query: 229 ILAATLDNTLKLWDYSK-----GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283
           IL+A+ D T+ +W  ++     G   +   GH +    +  +   + G++ +SGS D  +
Sbjct: 31  ILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVIS---SDGQFALSGSWDGTL 87

Query: 284 YIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKS 332
            +W+L T    ++  GHT  V+S A       I S +   DKTIKLW +
Sbjct: 88  RLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS--RDKTIKLWNT 134



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 36/137 (26%), Positives = 61/137 (44%), Gaps = 11/137 (8%)

Query: 34  NYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
           N  LK    GHT  +++V  SP+G   AS   D    +W   +GK   T+ G  + I+ +
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI-INAL 239

Query: 94  AWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK-------GHSNYVFCCN--FNPQSNLI 144
            +S +   L +A+   ++KIWD+     +  LK         +    C +  ++     +
Sbjct: 240 CFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298

Query: 145 VSGSFDESVRIWDVKTG 161
            +G  D  VR+W V  G
Sbjct: 299 FAGYTDNLVRVWQVTIG 315


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
           sapiens]
          Length = 1248

 Score =  123 bits (309), Expect = 2e-28
 Identities = 86/305 (28%), Positives = 156/305 (51%), Gaps = 23/305 (7%)

Query: 44  HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLV 103
           HT AV    FS +G+ +AS  ADK ++++ A  G+    I  H+  +   A+S+D   + 
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673

Query: 104 SASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSN--LIVSGSFDESVRIWDVKTG 161
           + S DK +KIW+  +G+ + T   HS  V CC+F   S+  L+ +GS D  +++WD+   
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733

Query: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--------IDDD 213
           +C  T+  H++ V+   F+ D  L+ S S DG  ++WD  S    K++        ++D 
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDP 793

Query: 214 NPPVSFV----KFSPNGKYILAATLDNTLKLWD-YSKGKCLKTYTGHKNE-KYCIFANFS 267
              +  +     +S +G  I+ A   N + L+D ++ G   + +TGH +  +YC   +FS
Sbjct: 794 QEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIHTSGLLGEIHTGHHSTIQYC---DFS 849

Query: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327
                 +V+ S+   V +WN  ++  V   +GH   V      P  +   +++  +D+TI
Sbjct: 850 PQNHLAVVALSQ-YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS--DDQTI 906

Query: 328 KLWKS 332
           +LW++
Sbjct: 907 RLWET 911



 Score =  103 bits (258), Expect = 2e-22
 Identities = 65/261 (24%), Positives = 119/261 (45%), Gaps = 17/261 (6%)

Query: 86  HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIV 145
           H   +    +S D   + S   DKTL+++   +G+ L  +K H + V CC F+     I 
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673

Query: 146 SGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS--LIVSSSYDGLCRIWDTASG 203
           + S D+ V+IW+  TG+ + T   HS+ V+  HF       L+ + S D   ++WD    
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733

Query: 204 QCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYT---------- 253
           +C  T+    N  V+  +FSP+ K + + + D TLKLWD +     K+            
Sbjct: 734 ECRNTMFGHTN-SVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLED 792

Query: 254 -GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT 312
                E      ++S  G + +V+    N ++++++ T  ++ ++       I       
Sbjct: 793 PQEDMEVIVKCCSWSADGARIMVAAK--NKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSP 850

Query: 313 ENIIASAALENDKTIKLWKSD 333
           +N +A  AL +   ++LW +D
Sbjct: 851 QNHLAVVAL-SQYCVELWNTD 870



 Score = 93.6 bits (231), Expect = 2e-19
 Identities = 72/308 (23%), Positives = 142/308 (46%), Gaps = 31/308 (10%)

Query: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
           +  H   V    FS +  ++A+ S DK +KIW +  G+   T   H   ++   +++ S+
Sbjct: 653 IKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSH 712

Query: 101 --LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
             LL + S D  LK+WD++  +C  T+ GH+N V  C F+P   L+ S S D ++++WD 
Sbjct: 713 HLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772

Query: 159 KTGKCLKTLPAH------SDP-------VSAVHFNRDGSLIVSSSYDGLCRIWDTASGQC 205
            +    K++          DP       V    ++ DG+ I+ ++ + +  ++D  +   
Sbjct: 773 TSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIF-LFDIHTSGL 831

Query: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFAN 265
           L  +    +  + +  FSP     + A     ++LW+      +    GH +  + +   
Sbjct: 832 LGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVM-- 889

Query: 266 FSVTGGKWIVSGSEDNLVYIWNLQTKEIVQK----LQGHTDVVISTACHPTENIIASAAL 321
           FS  G  ++ S S+D  + +W  +TK++ +     L+   DVV        EN +   A+
Sbjct: 890 FSPDGSSFLTS-SDDQTIRLW--ETKKVCKNSAVMLKQEVDVVFQ------ENEVMVLAV 940

Query: 322 ENDKTIKL 329
           ++ + ++L
Sbjct: 941 DHIRRLQL 948



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 81/340 (23%), Positives = 145/340 (42%), Gaps = 56/340 (16%)

Query: 40   TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHK--LGISD----- 92
            T+ GHT +V+  +FSP+ + LAS SAD  +K+W A      K+I+  +  L + D     
Sbjct: 738  TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDM 797

Query: 93   ------VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
                   +WS+D   ++ A+ +K       +SG   +   GH + +  C+F+PQ++L V 
Sbjct: 798  EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVV 857

Query: 147  GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA----- 201
                  V +W+  +   +     H   V  V F+ DGS  ++SS D   R+W+T      
Sbjct: 858  ALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKN 917

Query: 202  SGQCLKTLID---DDN----------------------------PPVSFVKFSPNGKYIL 230
            S   LK  +D    +N                              VS    SP+ +YI 
Sbjct: 918  SAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIA 977

Query: 231  AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT 290
                +  +++ +    +  ++   HK   + I   F+    K ++S S+D  + +WN Q 
Sbjct: 978  FGDENGAIEILELVNNRIFQSRFQHKKTVWHI--QFT-ADEKTLISSSDDAEIQVWNWQL 1034

Query: 291  KEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
             + +  L+GH + V          +++ +    D T+K+W
Sbjct: 1035 DKCI-FLRGHQETVKDFRLLKNSRLLSWSF---DGTVKVW 1070



 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 52/176 (29%), Positives = 80/176 (45%), Gaps = 11/176 (6%)

Query: 41   LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
            L GH + V   +   N   L S S D  +K+W    G  EK    H+  +     S D+ 
Sbjct: 1040 LRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDAT 1098

Query: 101  LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
               S S DKT KIW       L  L+GH+  V C  F+  S L+ +G  +  +RIW+V  
Sbjct: 1099 KFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158

Query: 161  GKCLKTLPAHSDPVSAVH--------FNRDGSLIVSSSYDGLCRIWDTASGQCLKT 208
            G+ L      S+  +A H        F+ DG +++S+   G  + W+  +G+  +T
Sbjct: 1159 GELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQT 1212



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 46/166 (27%), Positives = 85/166 (51%), Gaps = 8/166 (4%)

Query: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGS 184
           ++ H++ V+   F+     I S   D++++++  +TG+ L  + AH D V    F+ D  
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDR 670

Query: 185 LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAT--LDNTLKLWD 242
            I + S D   +IW++ +G+ + T  D+ +  V+   F+ +  ++L AT   D  LKLWD
Sbjct: 671 FIATCSVDKKVKIWNSMTGELVHT-YDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729

Query: 243 YSKGKCLKTYTGHKNE-KYCIFANFSVTGGKWIVSGSEDNLVYIWN 287
            ++ +C  T  GH N   +C F+       K + S S D  + +W+
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFS----PDDKLLASCSADGTLKLWD 771



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 60/325 (18%), Positives = 123/325 (37%), Gaps = 45/325 (13%)

Query: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
            GH   +    FSP       + +   +++W            GH   +  V +S D +  
Sbjct: 838  GHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSF 897

Query: 103  VSASDDKTLKIWD-----------------------------VSSGKCLKTLKGHSNY-- 131
            +++SDD+T+++W+                             V   + L+ + G +    
Sbjct: 898  LTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQID 957

Query: 132  ------VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
                  V CC  +P    I  G  + ++ I ++   +  ++   H   V  + F  D   
Sbjct: 958  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017

Query: 186  IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
            ++SSS D   ++W+    +C+   +      V   +   N + +L+ + D T+K+W+   
Sbjct: 1018 LISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIIT 1074

Query: 246  GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVI 305
            G   K +  H+        +   T      S S D    IW+      + +L+GH   V 
Sbjct: 1075 GNKEKDFVCHQGTVLSCDISHDATK---FSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1131

Query: 306  STACHPTENIIASAALENDKTIKLW 330
             +A      ++A+   +++  I++W
Sbjct: 1132 CSAFSVDSTLLATG--DDNGEIRIW 1154



 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 55/289 (19%), Positives = 111/289 (38%), Gaps = 43/289 (14%)

Query: 43   GHTKAVSSVKFSPNGEWLASSSADKLIKIWGA--------------YDGKFEKT------ 82
            GH   V  V FSP+G    +SS D+ I++W                 D  F++       
Sbjct: 880  GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLA 939

Query: 83   ---------ISGH--------KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL 125
                     I+G         +  +S    S     +    ++  ++I ++ + +  ++ 
Sbjct: 940  VDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSR 999

Query: 126  KGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSL 185
              H   V+   F      ++S S D  +++W+ +  KC+  L  H + V      ++  L
Sbjct: 1000 FQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLKNSRL 1058

Query: 186  IVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
            + S S+DG  ++W+  +G   K  +      +S    S +     + + D T K+W +  
Sbjct: 1059 L-SWSFDGTVKVWNIITGNKEKDFVCHQGTVLS-CDISHDATKFSSTSADKTAKIWSFDL 1116

Query: 246  GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
               L    GH     C+  +        + +G ++  + IWN+   E++
Sbjct: 1117 LLPLHELRGHNG---CVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELL 1162



 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 44/166 (26%), Positives = 76/166 (45%), Gaps = 12/166 (7%)

Query: 44   HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE-KTISGHKLGISDVAWSSDSNLL 102
            H   V S   S +    +S+SADK  KIW ++D       + GH   +   A+S DS LL
Sbjct: 1084 HQGTVLSCDISHDATKFSSTSADKTAKIW-SFDLLLPLHELRGHNGCVRCSAFSVDSTLL 1142

Query: 103  VSASDDKTLKIWDVSSGKCL--------KTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
             +  D+  ++IW+VS+G+ L        +    H  +V    F+P   +++S      ++
Sbjct: 1143 ATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIK 1200

Query: 155  IWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
             W+V TG+  +T   +   +  +H + D    V+    G+  I  T
Sbjct: 1201 WWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQT 1246


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,681,486
Number of Sequences: 37866
Number of extensions: 597517
Number of successful extensions: 6469
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 303
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 1669
Number of HSP's gapped (non-prelim): 1845
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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