Guide to the Human Genome
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Search of human proteins with 163965434

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|163965434 dapper, antagonist of beta-catenin, homolog 2
[Homo sapiens]
         (774 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|163965434 dapper, antagonist of beta-catenin, homolog 2 [Homo...  1576   0.0  
gi|24158478 dapper 1 isoform 1 [Homo sapiens]                         179   1e-44
gi|118498364 dapper 1 isoform 2 [Homo sapiens]                        105   1e-22
gi|182507165 thymus expressed gene 3-like [Homo sapiens]               84   6e-16
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    52   2e-06
gi|144953905 hypothetical protein LOC55138 [Homo sapiens]              52   2e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    49   2e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    47   9e-05
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    46   2e-04
gi|150170670 piccolo isoform 2 [Homo sapiens]                          46   2e-04
gi|150378539 piccolo isoform 1 [Homo sapiens]                          46   2e-04
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                   45   2e-04
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       44   6e-04
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       42   0.002
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    41   0.004
gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Ho...    41   0.005
gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Ho...    41   0.005
gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Ho...    41   0.005
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    41   0.005
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    41   0.005
gi|188536004 zinc finger protein 469 [Homo sapiens]                    41   0.005
gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]      41   0.005
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               41   0.005
gi|156151396 heterogeneous nuclear ribonucleoprotein R isoform 3...    40   0.006
gi|156151394 heterogeneous nuclear ribonucleoprotein R isoform 1...    40   0.006
gi|156151392 heterogeneous nuclear ribonucleoprotein R isoform 4...    40   0.006
gi|5031755 heterogeneous nuclear ribonucleoprotein R isoform 2 [...    40   0.006
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    40   0.008
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    40   0.008
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]            40   0.008

>gi|163965434 dapper, antagonist of beta-catenin, homolog 2 [Homo
           sapiens]
          Length = 774

 Score = 1576 bits (4080), Expect = 0.0
 Identities = 774/774 (100%), Positives = 774/774 (100%)

Query: 1   MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCG 60
           MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCG
Sbjct: 1   MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCG 60

Query: 61  PHGLHGPEQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDS 120
           PHGLHGPEQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDS
Sbjct: 61  PHGLHGPEQQLEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDS 120

Query: 121 DSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVD 180
           DSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVD
Sbjct: 121 DSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVD 180

Query: 181 ETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAE 240
           ETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAE
Sbjct: 181 ETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAE 240

Query: 241 LLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGG 300
           LLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGG
Sbjct: 241 LLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGG 300

Query: 301 PSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHA 360
           PSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHA
Sbjct: 301 PSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHA 360

Query: 361 ASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSL 420
           ASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSL
Sbjct: 361 ASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSL 420

Query: 421 PEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFAH 480
           PEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFAH
Sbjct: 421 PEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFAH 480

Query: 481 PSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWP 540
           PSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWP
Sbjct: 481 PSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWP 540

Query: 541 TGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQALFPFEASLLTS 600
           TGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQALFPFEASLLTS
Sbjct: 541 TGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQALFPFEASLLTS 600

Query: 601 VARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSD 660
           VARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSD
Sbjct: 601 VARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSD 660

Query: 661 SEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYV 720
           SEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYV
Sbjct: 661 SEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYV 720

Query: 721 AAGHAELAWTQEAPVSSGPLLSPVPKLCRIKASKALKKKIRRFQPTALKVMTMV 774
           AAGHAELAWTQEAPVSSGPLLSPVPKLCRIKASKALKKKIRRFQPTALKVMTMV
Sbjct: 721 AAGHAELAWTQEAPVSSGPLLSPVPKLCRIKASKALKKKIRRFQPTALKVMTMV 774


>gi|24158478 dapper 1 isoform 1 [Homo sapiens]
          Length = 836

 Score =  179 bits (453), Expect = 1e-44
 Identities = 241/872 (27%), Positives = 348/872 (39%), Gaps = 176/872 (20%)

Query: 9   GSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCGPHGLHGPE 68
           G A  +R+R   R  A  AGL EL+ LR  Q+  VRGAL        AAP     L    
Sbjct: 35  GEADTERQRTRERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGELLGEAA 94

Query: 69  QQ-------LEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDSD 121
           Q+       LE  +  L++QL+ LR++D GL   L +LD QIS L+LDV   S E L++D
Sbjct: 95  QRSRLEEKFLEENILLLRKQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETD 154

Query: 122 SRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVDE 181
           SRPSSGFYE+SDG S SLS S  SV S+ +S S  S        +A  S+ D  P+S D 
Sbjct: 155 SRPSSGFYELSDGASGSLSNSSNSVFSECLS-SCHSSTCFCSPLEATLSLSDGCPKSADL 213

Query: 182 TTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAEL 241
             +  ++    E+ A   G+V            R +ST   +                  
Sbjct: 214 IGLLEYKEGHCEDQA--SGAV-----------CRSLSTPQFN------------------ 242

Query: 242 LGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGGP 301
                  +D+   V +PKY+ DLVS+ G +VY YPSPLHAVA+QSP+F+L       G P
Sbjct: 243 ------SLDVIADV-NPKYQCDLVSKNGNDVYRYPSPLHAVAVQSPMFLLC----LTGNP 291

Query: 302 SFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGE-------Q 354
              RE  R     + I  G  L+A   +  + +     LW    P+   + +       Q
Sbjct: 292 L--REEDRLGNHASDICGGSELDA--VKTDSSLPSPSSLWSASHPSSSKKMDGYILSLVQ 347

Query: 355 GPLRHAASPSPQRQGGWSTDGG----GRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMP 410
                  +  P+         G    G + V APG   +G     + + +      G   
Sbjct: 348 KKTHPVRTNKPRTSVNADPTKGLLRNGSVCVRAPGGVSQGNSVNLKNSKQACLPSGGIPS 407

Query: 411 LEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKS 470
           L     + S P++ SK S +             SK    P     G  + +  S+ L K+
Sbjct: 408 LN--NGTFSPPKQWSKESKA---------EQAESKRVPLPEGCPSGAASDLQ-SKHLPKT 455

Query: 471 PSPASGHFAH---------PSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRP 521
             PAS   A          P  +A L    PK   E   R P         QPL  + + 
Sbjct: 456 AKPASQEHARCSAIGTGESPKESAQLSGASPK---ESPSRGPAPPQENKVVQPLKKMSQK 512

Query: 522 EGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCS-ESTLYPMPVLVP------ 574
                 P  +       +P     ++ RPAL +++ G S S E         +P      
Sbjct: 513 NSLQGVPPATPPLLSTAFP-----VEERPALDFKSEGSSQSLEEAHLVKAQFIPGQQPSV 567

Query: 575 --------LAVAPQESHRTSAQALFPFEASLLT----SVARRKHRRWQSTVEISARARLA 622
                   + V    S +    AL   E  L T    + A  K  R+   ++ + + + A
Sbjct: 568 RLHRGHRNMGVVKNSSLKHRGPALQGLENGLPTVREKTRAGSKKCRFPDDLDTNKKLKKA 627

Query: 623 SC--------PESNL-GPPRPVARRAGGPL-ARGRPSLVRQDAYTRSD------------ 660
           S         PE+ + G P     RAG      GR ++V +  + R+D            
Sbjct: 628 SSKGRKSGGGPEAGVPGRPAGGGHRAGSRAHGHGREAVVAKPKHKRTDYRRWKSSAEISY 687

Query: 661 ---------------------------------SEPSKHSAECDPRFPSVIPETSEGESS 687
                                            +  S++SAEC+  F S + +TSE E S
Sbjct: 688 EEALRRARRGRRENVGLYPAPVPLPYASPYAYVASDSEYSAECESLFHSTVVDTSEDEQS 747

Query: 688 DHTTNRFGDRESSSSDEEGGAQS---RDCDLALGYVAAGHAELAWTQEAPVSSGPLL--S 742
           ++TTN FGD ESS S+ E   +S    D + + G +    ++   T      + P L   
Sbjct: 748 NYTTNCFGDSESSVSEGEFVGESTTTSDSEESGGLI---WSQFVQTLPIQTVTAPDLHNH 804

Query: 743 PVPKLCRIKASKALKKKIRRFQPTALKVMTMV 774
           P     +IKAS  LKKKI RF+  +LK+MT V
Sbjct: 805 PAKTFVKIKASHNLKKKILRFRSGSLKLMTTV 836


>gi|118498364 dapper 1 isoform 2 [Homo sapiens]
          Length = 799

 Score =  105 bits (263), Expect = 1e-22
 Identities = 77/179 (43%), Positives = 98/179 (54%), Gaps = 8/179 (4%)

Query: 9   GSAGWDRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCGPHGLHGPE 68
           G A  +R+R   R  A  AGL EL+ LR  Q+  VRGAL        AAP     L    
Sbjct: 35  GEADTERQRTRERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGELLGEAA 94

Query: 69  QQ-------LEAALAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDSD 121
           Q+       LE  +  L++QL+ LR++D GL   L +LD QIS L+LDV   S E L++D
Sbjct: 95  QRSRLEEKFLEENILLLRKQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETD 154

Query: 122 SRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVD 180
           SRPSSGFYE+SDG S SLS S  SV S+ +S S  S        +A  S+ D  P+S D
Sbjct: 155 SRPSSGFYELSDGASGSLSNSSNSVFSECLS-SCHSSTCFCSPLEATLSLSDGCPKSAD 212



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 155/617 (25%), Positives = 232/617 (37%), Gaps = 130/617 (21%)

Query: 257 DPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNT 316
           +PKY+ DLVS+ G +VY YPSPLHAVA+QSP+F+L       G P   RE  R     + 
Sbjct: 214 NPKYQCDLVSKNGNDVYRYPSPLHAVAVQSPMFLLC----LTGNPL--REEDRLGNHASD 267

Query: 317 IQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGE-------QGPLRHAASPSPQRQG 369
           I  G  L+A   +  + +     LW    P+   + +       Q       +  P+   
Sbjct: 268 ICGGSELDA--VKTDSSLPSPSSLWSASHPSSSKKMDGYILSLVQKKTHPVRTNKPRTSV 325

Query: 370 GWSTDGG----GRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGS 425
                 G    G + V APG   +G     + + +      G   L     + S P++ S
Sbjct: 326 NADPTKGLLRNGSVCVRAPGGVSQGNSVNLKNSKQACLPSGGIPSLN--NGTFSPPKQWS 383

Query: 426 KPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFAH----- 480
           K S +             SK    P     G  + +  S+ L K+  PAS   A      
Sbjct: 384 KESKA---------EQAESKRVPLPEGCPSGAASDLQ-SKHLPKTAKPASQEHARCSAIG 433

Query: 481 ----PSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDP 536
               P  +A L    PK   E   R P         QPL  + +       P  +     
Sbjct: 434 TGESPKESAQLSGASPK---ESPSRGPAPPQENKVVQPLKKMSQKNSLQGVPPATPPLLS 490

Query: 537 AHWPTGRGGLQRRPALAWEAPGRSCS-ESTLYPMPVLVP--------------LAVAPQE 581
             +P     ++ RPAL +++ G S S E         +P              + V    
Sbjct: 491 TAFP-----VEERPALDFKSEGSSQSLEEAHLVKAQFIPGQQPSVRLHRGHRNMGVVKNS 545

Query: 582 SHRTSAQALFPFEASLLT----SVARRKHRRWQSTVEISARARLASC--------PESNL 629
           S +    AL   E  L T    + A  K  R+   ++ + + + AS         PE+ +
Sbjct: 546 SLKHRGPALQGLENGLPTVREKTRAGSKKCRFPDDLDTNKKLKKASSKGRKSGGGPEAGV 605

Query: 630 -GPPRPVARRAGGPL-ARGRPSLVRQDAYTRSD--------------------------- 660
            G P     RAG      GR ++V +  + R+D                           
Sbjct: 606 PGRPAGGGHRAGSRAHGHGREAVVAKPKHKRTDYRRWKSSAEISYEEALRRARRGRRENV 665

Query: 661 ------------------SEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSS 702
                             +  S++SAEC+  F S + +TSE E S++TTN FGD ESS S
Sbjct: 666 GLYPAPVPLPYASPYAYVASDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVS 725

Query: 703 DEEGGAQS---RDCDLALGYVAAGHAELAWTQEAPVSSGPLL--SPVPKLCRIKASKALK 757
           + E   +S    D + + G +    ++   T      + P L   P     +IKAS  LK
Sbjct: 726 EGEFVGESTTTSDSEESGGLI---WSQFVQTLPIQTVTAPDLHNHPAKTFVKIKASHNLK 782

Query: 758 KKIRRFQPTALKVMTMV 774
           KKI RF+  +LK+MT V
Sbjct: 783 KKILRFRSGSLKLMTTV 799


>gi|182507165 thymus expressed gene 3-like [Homo sapiens]
          Length = 629

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 205/794 (25%), Positives = 270/794 (34%), Gaps = 209/794 (26%)

Query: 14  DRRRLGARLRAAFAGLQELQGLRATQQERVRGALALQPPPAPAAPCGPHGLHGPEQQLEA 73
           +R RL   L  + AGL EL  LR  Q+ RV+ AL L  P    A          ++   A
Sbjct: 12  ERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDADEDEDAAA 71

Query: 74  A---LAALQEQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEALDSDSRPSSGFYE 130
           A    AAL+EQL  L     GL   L Q   Q+  L L+ G      L+ +S  SSGFYE
Sbjct: 72  ARRAAAALEEQLEALP----GLVWDLGQ---QLGDLSLESG-----GLEQESGRSSGFYE 119

Query: 131 --MSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVDETTVPAWR 188
              S GG  S  ++         S S G L P     + R      RP+S+ + +     
Sbjct: 120 DPSSTGGPDSPPSTFCGDSGFSGSSSYGRLGP----SEPRGIYASERPKSLGDAS----- 170

Query: 189 PQATEE-GARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGLLCQ 247
           P A E  GAR       A  P     P P + G             +A + AE       
Sbjct: 171 PSAPEVVGAR-------AAVPRSFSAPYPTAGGSAG---------PEACSSAE------- 207

Query: 248 GVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKET--PQRGGPSFPR 305
                              +     +  PSPLHAVA++SP       T  P  GG   P 
Sbjct: 208 ------------------RRARAGPFLTPSPLHAVAMRSPRPCGRPPTDSPDAGGAGRPL 249

Query: 306 ES-------PRGPAGLNTIQTGPV-LEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPL 357
           +         R   G    +T P   + GP R  +          R+ P   S    G  
Sbjct: 250 DGYISALLRRRRRRGAGQPRTSPGGADGGPRRQNSV---------RQRPPDASPSP-GSA 299

Query: 358 RHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQS 417
           R A  PS +R GG  T        +A   E E  P                     P   
Sbjct: 300 RPAREPSLERVGGHPTSPAALSRAWASSWESEAAPE--------------------PAAP 339

Query: 418 GSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGH 477
            + P     P+   ++           KAQ  P AQ   RG    P R   + P      
Sbjct: 340 PAAPSPPDSPAEGRLV-----------KAQYIPGAQAATRG---LPGRAARRKP------ 379

Query: 478 FAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPA 537
                        PP ++   +++SP  +  R A +      R   A A+ +        
Sbjct: 380 -------------PPLTRGRSVEQSPPRERPRAAGR------RGRMAEASGR-------- 412

Query: 538 HWPTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLA-----VAPQESHRTSAQALFP 592
                RG  + R A       RS SE++L      VP        A +E  R       P
Sbjct: 413 -----RGSPRARKA------SRSQSETSLLGRASAVPSGPPKYPTAEREEPRPPRPRRGP 461

Query: 593 FEASLLTSVARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVR 652
             A  L + A    RRW+ST EI A           + P  P AR  G   +   P    
Sbjct: 462 --APTLAAQAAGSCRRWRSTAEIDA------ADGRRVRPRAPAARVPGPGPSPSAPQRRL 513

Query: 653 QDAYTRSDSEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGA---Q 709
                 SDSE S              P    G +       +G+ ESS+S+ E  A    
Sbjct: 514 LYGCAGSDSECSAGRLG---------PLGRRGPAGG-VGGGYGESESSASEGESPAFSSA 563

Query: 710 SRDCDLALGYVAAGHAELAWTQEAPVSS---------GPLLSPVPKLCRIKASKALKKKI 760
           S D D        G   L W Q+   ++         G    P     +IKAS ALKKKI
Sbjct: 564 SSDSD--------GSGGLVWPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKKI 615

Query: 761 RRFQPTALKVMTMV 774
            RF+  +LKVMT V
Sbjct: 616 LRFRSGSLKVMTTV 629


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 90/337 (26%), Positives = 119/337 (35%), Gaps = 75/337 (22%)

Query: 294 ETPQRGGPSFPRESP------RGPAGLNTIQTGPVLEAGPARARAYIDRL----LHLWGR 343
           E+  R GP+     P      R P   NT   GPV   G A        L    L +   
Sbjct: 72  ESAPRAGPTRTSRPPASGRGERAPPAKNT-SPGPVSSPGRASGTTRPGPLGQKGLRISAE 130

Query: 344 ETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAG---- 399
           ET A+G   E  P R A S   +R     T          PG        +SR AG    
Sbjct: 131 ETVARGKATE-APKRSALSAGARRDTSGPT----------PGTPSPAMARRSRAAGTEVG 179

Query: 400 --RGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGR 457
             R  P  +   P EGP++S S   E S                PS  A++ PSA   G 
Sbjct: 180 LPRPAPSARPRPPTEGPRKSVSSASEHS-------------TTEPSPAARRRPSA---GG 223

Query: 458 GNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLL 517
           G     SR L  S +P S     P+ +     G P++ A      P  K L+  R P + 
Sbjct: 224 GLQRPASRSLSSSATPLSS----PARSGPSARGTPRAPAH--PSQPKPKGLQALRPPQVT 277

Query: 518 LDRPEGAH----------AAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSE---- 563
             R + A           A P PS    P+  P+    LQ  P+     P ++ +     
Sbjct: 278 PPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPS----LQTLPSPPATPPSQATTSLGSP 333

Query: 564 -----STLYPMPVLVPLAVAPQESHRTSAQALFPFEA 595
                 +  P P L PLA  P ++    A AL P +A
Sbjct: 334 TLQATHSFLPSPPLSPLATPPPQA--PPALALPPLQA 368



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 90/384 (23%), Positives = 119/384 (30%), Gaps = 57/384 (14%)

Query: 123 RPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPSMGDWRPRSVDET 182
           RPS+G   +    S SLS+S   + S   S       P A AH ++P     +P+ +   
Sbjct: 218 RPSAGG-GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP-----KPKGLQAL 271

Query: 183 TVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELL 242
             P   P             +DA    G     P++T       P+ +     SA   L 
Sbjct: 272 RPPQVTPPR-----------KDAAPALGPLSSSPLAT-------PSPSAPPSPSAPPSL- 312

Query: 243 GLLCQGVDIPLHVPDPKYRQDLVS---QGGREVYPYPSPLHAVALQSPLFVLTKETPQRG 299
               Q +  P   P  +    L S   Q      P P PL  +A   P        P   
Sbjct: 313 ----QTLPSPPATPPSQATTSLGSPTLQATHSFLPSP-PLSPLATPPPQAPPALALPPLQ 367

Query: 300 GPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRH 359
            P  P  SP            P+    P    A    LL       P   S   Q P   
Sbjct: 368 APPSPPASP---------PLSPLATPSPQAPNALAVHLLQAPFSPPP---SPPVQAPFSP 415

Query: 360 AASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGS 419
            ASP P              L   P +     PA    +    P  Q   PL  P    +
Sbjct: 416 PASP-PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLA 474

Query: 420 LPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGHFA 479
            P   + P+           A+P  +A  +P A   G+    SPS  L  SP       A
Sbjct: 475 KPPPQAPPA----------LATPPLQALPSPPASFPGQAPF-SPSASLPMSPLATPPPQA 523

Query: 480 HPSFAASLKMGPPKSKAEKIKRSP 503
            P  AA L   PP   A    ++P
Sbjct: 524 PPVLAAPLLQVPPSPPASPTLQAP 547


>gi|144953905 hypothetical protein LOC55138 [Homo sapiens]
          Length = 464

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 88/371 (23%), Positives = 132/371 (35%), Gaps = 61/371 (16%)

Query: 337 LLHLWGRETPAKGSEGEQGP------LRHAASPSP---------------QRQGGWSTDG 375
           LLH++ R+ P K    ++G       LR A+ P P                R     +D 
Sbjct: 117 LLHIFSRKPPEKPLPNQKGSTESSDYLRVASGPMPVHTTSKRPRVDPVLSDRSATEMSDR 176

Query: 376 GGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRE 435
           G  L   +P R+     + S G           +P    +  G  P    KP++S     
Sbjct: 177 GSVLASLSPLRKASLSSSSSLGPKERQTGAAADIPQTAVRHQGPEPLLVVKPTHS----- 231

Query: 436 TMVQASPSSKAQQTPSA--QDYGRGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPK 493
                SP+   ++ P A  + +G    +SP    DK P+  S     P+   SL +G   
Sbjct: 232 -----SPAGGCREVPQAASKTHGLLQAVSPQAQ-DKRPAVTSQP-CPPAATHSLGLGSNL 284

Query: 494 SKAEKIKRS---PMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRP 550
           S     KRS   P+   L F ++P L      G    P+ +++      P     LQ  P
Sbjct: 285 SFGPGAKRSAPAPIQACLNFPKKPRL------GPFQIPESAIQGGELGAPEN---LQPPP 335

Query: 551 ALAWEAPGRSCSESTLYPMPVL------------VPLAVAPQESHRTSAQALFPFEASLL 598
           A     P  S    T  P  VL            +P A A   SH  +A         L 
Sbjct: 336 AATELGPRTSPQTGTRTPAQVLSGDRQPPHSRPCLPTAQACTMSHHPAAS--HDGAQPLR 393

Query: 599 TSVARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTR 658
               R ++ RW S++  +        P + L     V+ ++ GP  R  PS++ +D    
Sbjct: 394 VLFRRLENGRWSSSLLTAPSFHSPEKPGAFLAQSPHVSEKSEGPCVRVPPSVLYEDLQVP 453

Query: 659 SDSEPSKHSAE 669
           S SE S    E
Sbjct: 454 SSSEDSDSDLE 464


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 81/303 (26%), Positives = 108/303 (35%), Gaps = 57/303 (18%)

Query: 295 TPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQ 354
           T  R   S P  S RG        T P   + P RA              T   G  G++
Sbjct: 85  TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASG------------TTRPGPLGQK 132

Query: 355 GPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPA----------QSRGAG----- 399
           G LR +A  +  R  G +T+   R  + A  R D  GP           +SR AG     
Sbjct: 133 G-LRISAEETVAR--GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189

Query: 400 -RGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRG 458
            R  P  +   P EGP++S S   E S                PS  A++ PSA   G G
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHS-------------TTEPSPAARRRPSA---GGG 233

Query: 459 NIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLL 518
                SR L  S +P S     P+ +     G P++ A      P  K L+  R P +  
Sbjct: 234 LQRPASRSLSSSATPLSS----PARSGPSARGTPRAPAH--PSQPKPKGLQALRPPQVTP 287

Query: 519 DRPEGAHAAPQPSLEWDPAHWPTGRGGLQRR--PALAWEAPGRSCSESTLYPMPVLVPLA 576
            R + A A     L   P   P+    LQ +  P L       S +     P+P+  P  
Sbjct: 288 PRKDAAPAL--GPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345

Query: 577 VAP 579
            AP
Sbjct: 346 SAP 348



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 96/391 (24%), Positives = 122/391 (31%), Gaps = 41/391 (10%)

Query: 123 RPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGSLLPVAQAHKARPS---MGDWRPRSV 179
           RPS+G   +    S SLS+S   + S   S       P A AH ++P    +   RP  V
Sbjct: 227 RPSAGG-GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQV 285

Query: 180 D---ETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTG-DLDRALPADTGLQKA 235
               +   PA  P ++   A P  S     Q   T    P S+      A P        
Sbjct: 286 TPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345

Query: 236 SADAELLGLLCQGVDIPLHVPDPKYRQDLVS---QGGREVYPYPSPLHAVALQSPLFVLT 292
           SA   L     Q +  P   P  +    L S   Q      P P PL  +A   P     
Sbjct: 346 SAPPSL-----QTLPSPPATPPSQATTSLGSPTLQATHSFLPSP-PLSPLATPPPQAPPA 399

Query: 293 KETPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEG 352
              P    P  P  SP            P+    P    A    LL       P   S  
Sbjct: 400 LALPPLQAPPSPPASP---------PLSPLATPSPQAPNALAVHLLQAPFSPPP---SPP 447

Query: 353 EQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLE 412
            Q P    ASP P              L   P +     PA    +    P  Q   PL 
Sbjct: 448 VQAPFSPPASP-PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA 506

Query: 413 GPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPS 472
            P    + P   + P+           A+P  +A  +P A   G+    SPS  L  SP 
Sbjct: 507 APPLQLAKPPPQAPPA----------LATPPLQALPSPPASFPGQAPF-SPSASLPMSPL 555

Query: 473 PASGHFAHPSFAASLKMGPPKSKAEKIKRSP 503
                 A P  AA L   PP   A    ++P
Sbjct: 556 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 84/304 (27%), Positives = 112/304 (36%), Gaps = 62/304 (20%)

Query: 295 TPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQ 354
           T  R   S P  S RG        T P   + P RA              T   G  G++
Sbjct: 85  TSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASG------------TTRPGPLGQK 132

Query: 355 GPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPA----------QSRGAG----- 399
           G LR +A  +  R  G +T+   R  + A  R D  GP           +SR AG     
Sbjct: 133 G-LRISAEETVAR--GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 189

Query: 400 -RGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRG 458
            R  P  +   P EGP++S S   E S                PS  A++ PSA   G G
Sbjct: 190 PRPAPSARPRPPTEGPRKSVSSASEHS-------------TTEPSPAARRRPSA---GGG 233

Query: 459 NIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLL 518
                SR L  S +P S     P+ +     G P++ A      P  K L+  R P +  
Sbjct: 234 LQRPASRSLSSSATPLSS----PARSGPSARGTPRAPAH--PSQPKPKGLQALRPPQVTP 287

Query: 519 DRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCS--ESTLYPMPVL-VPL 575
            R + A A     L   P   P+   G + RP      P  + +   +TL P P L  PL
Sbjct: 288 PRKDAAPAL--GPLSSSPLATPS-PSGTKARPV---PPPDNAATPLPATLPPSPPLATPL 341

Query: 576 AVAP 579
            +AP
Sbjct: 342 PLAP 345



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 95/382 (24%), Positives = 126/382 (32%), Gaps = 55/382 (14%)

Query: 271 EVYPYPSPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNT--IQTGPVLEAGP- 327
           E  P P+P    A  SPL     ETP     S     P+ P  L +  +Q  P     P 
Sbjct: 559 ETPPCPAPCPLQAPPSPLTTPPPETPS----SIATPPPQAPPALASPPLQGLPSPPLSPL 614

Query: 328 ARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGRE 387
           A         L L   + P   S     PL   A+PSPQ     +       L+ AP   
Sbjct: 615 ATPPPQAPPXLALPPLQAPP--SPPASPPLSPLATPSPQAPNALAVH-----LLQAPFSP 667

Query: 388 DEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQ 447
               P Q+  +    P          P    + P   + P  S       V  SP +   
Sbjct: 668 PPSPPVQAPFSPPASP----------PVSPSATPPSQAPP--SLAAPPLQVPPSPPASPP 715

Query: 448 QTPSAQDYGRGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKV 507
            +PSA    +      +  L   PSP +     PS     ++ PP   A  ++  P    
Sbjct: 716 MSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRV-PPLLAAPPLQVPPSPP- 773

Query: 508 LRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRS-CSESTL 566
              A  P+  L +P     AP P+L   P         LQ  P+     PG++  S S  
Sbjct: 774 ---ASLPMSPLAKP--PPQAP-PALATPP---------LQALPSPPASFPGQAPFSPSAS 818

Query: 567 YPMPVLVPLAVAPQESHRTSAQALFPF----EASLLTSVARRKHRRWQSTVEISARARLA 622
            PM    PLA  P ++    A  L        AS      RR       T     R  LA
Sbjct: 819 LPMS---PLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLA 875

Query: 623 SCPESNLGPPRPVARRAGGPLA 644
             P    GPP P +R     L+
Sbjct: 876 LAP----GPPPPPSRSPSSTLS 893


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 76/339 (22%), Positives = 122/339 (35%), Gaps = 49/339 (14%)

Query: 264 LVSQGGREVYPYPSPLH-AVALQSPLFVLTKETPQRGGPSFPRE-SPRGPAGLN------ 315
           LV+ G   + P P P      +Q+P FV     P    PS P   +P  PA         
Sbjct: 217 LVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPA 276

Query: 316 --TIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQRQGGWST 373
             T+   P   AGP  A   +           PA    G  G    A +P+P   G    
Sbjct: 277 PATLARPPGHPAGPPTAAPAVP---------PPAAAQNG--GSAGAAPAPAPAAGGPAGV 325

Query: 374 DG----GGRLLVFAPG-------REDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPE 422
            G    G      APG       R  +  P  ++     GP       + GP   G+LP 
Sbjct: 326 SGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPS 385

Query: 423 EGSKPSNSCVLRETMVQASPSSKAQ---QTPSAQDYGRGNIISPSRMLDKSPSPASGHFA 479
             + P  +      + + +  +  Q   +TP+A   G    ++P+ +  + P P      
Sbjct: 386 PAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQ---- 441

Query: 480 HPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHW 539
           +P+   + ++ P       + RS   ++L   +Q L  +     AHA PQ ++   PA  
Sbjct: 442 NPTNIQNFQLPP----GMVLVRSENGQLLMIPQQALAQMQAQ--AHAQPQTTMAPRPA-T 494

Query: 540 PTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVA 578
           PT    +Q       +APG       + P  ++  ++ A
Sbjct: 495 PTSAPPVQISTV---QAPGTPIIARQVTPTTIIKQVSQA 530


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 75/297 (25%), Positives = 102/297 (34%), Gaps = 53/297 (17%)

Query: 185 PAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGL 244
           PA     T+  A+ PG+V+   QP GT  P     G   +     TG +K S++      
Sbjct: 332 PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPA-KPPAQQTGSEKPSSEQPGPKA 390

Query: 245 LCQGVDI---PLHVPDPKYRQDLVSQGGREVYPYPSPL-HAVALQSPLFVL--TKETPQR 298
           L Q   +   P   P P   +    Q G      P PL     LQSP      TK   Q+
Sbjct: 391 LAQPPGVGKTPAQQPGPA--KPPTQQVGT-----PKPLAQQPGLQSPAKAPGPTKTPVQQ 443

Query: 299 GGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLR 358
            GP        GP   +  QTGP                        PAK    + GP  
Sbjct: 444 PGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG---------------PAKPPPQQPGP-- 486

Query: 359 HAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSG 418
             A P PQ+ G                      P+Q  G+ +  PQQ G      PQQ G
Sbjct: 487 --AKPPPQQPGSAKP------------------PSQQPGSTKPPPQQPGPAK-PSPQQPG 525

Query: 419 SLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPAS 475
           S      +P ++    +    A PS++    P +Q  G G  + P  +   +  P S
Sbjct: 526 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT-GSGKPLQPPTVSPSAKQPPS 581



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 71/321 (22%), Positives = 109/321 (33%), Gaps = 62/321 (19%)

Query: 153  PSLGSLLPVAQAHKARPSMGDWRPRSVDETT------VPAWRPQATEEGARPPGSVEDAG 206
            PS     PVA     +P M       V  ++      +P+ + Q+  E    P    D+ 
Sbjct: 741  PSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800

Query: 207  QPWGTFWPRPVSTGDLD-RALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLV 265
            +P  +F P        D +A+P      + ++D++++             P P       
Sbjct: 801  KPSQSFPPTGEKVSPFDSKAIP------RPASDSKIISH-----------PGPSSE---- 839

Query: 266  SQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTI-QTGPVLE 324
            S+G ++V P          + P    TK +P+      P+ SP  P    T  QT P  +
Sbjct: 840  SKGQKQVDPVQKK------EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQ 893

Query: 325  AGPARARAYIDRLLHLWG-----RETPAKGSEGEQGPL-RHAASPSPQRQGGWSTDGGGR 378
              P          L+L       +  P    E   G L    AS   Q     ST G   
Sbjct: 894  QSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG--- 950

Query: 379  LLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKP----SNSCVLR 434
                 PG   + GP        G P +Q   P + P   G     G  P     +  V +
Sbjct: 951  ----QPGPHSQSGP--------GAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK 998

Query: 435  ETMVQASP--SSKAQQTPSAQ 453
            ET   A+     KA+Q P+ +
Sbjct: 999  ETKAPAAEKLEPKAEQAPTVK 1019


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 75/297 (25%), Positives = 102/297 (34%), Gaps = 53/297 (17%)

Query: 185 PAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGL 244
           PA     T+  A+ PG+V+   QP GT  P     G   +     TG +K S++      
Sbjct: 332 PAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPA-KPPAQQTGSEKPSSEQPGPKA 390

Query: 245 LCQGVDI---PLHVPDPKYRQDLVSQGGREVYPYPSPL-HAVALQSPLFVL--TKETPQR 298
           L Q   +   P   P P   +    Q G      P PL     LQSP      TK   Q+
Sbjct: 391 LAQPPGVGKTPAQQPGPA--KPPTQQVGT-----PKPLAQQPGLQSPAKAPGPTKTPVQQ 443

Query: 299 GGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLR 358
            GP        GP   +  QTGP                        PAK    + GP  
Sbjct: 444 PGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG---------------PAKPPPQQPGP-- 486

Query: 359 HAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSG 418
             A P PQ+ G                      P+Q  G+ +  PQQ G      PQQ G
Sbjct: 487 --AKPPPQQPGSAKP------------------PSQQPGSTKPPPQQPGPAK-PSPQQPG 525

Query: 419 SLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPAS 475
           S      +P ++    +    A PS++    P +Q  G G  + P  +   +  P S
Sbjct: 526 STKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQT-GSGKPLQPPTVSPSAKQPPS 581



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 71/321 (22%), Positives = 109/321 (33%), Gaps = 62/321 (19%)

Query: 153  PSLGSLLPVAQAHKARPSMGDWRPRSVDETT------VPAWRPQATEEGARPPGSVEDAG 206
            PS     PVA     +P M       V  ++      +P+ + Q+  E    P    D+ 
Sbjct: 741  PSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTDSA 800

Query: 207  QPWGTFWPRPVSTGDLD-RALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLV 265
            +P  +F P        D +A+P      + ++D++++             P P       
Sbjct: 801  KPSQSFPPTGEKVSPFDSKAIP------RPASDSKIISH-----------PGPSSE---- 839

Query: 266  SQGGREVYPYPSPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTI-QTGPVLE 324
            S+G ++V P          + P    TK +P+      P+ SP  P    T  QT P  +
Sbjct: 840  SKGQKQVDPVQKK------EEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQ 893

Query: 325  AGPARARAYIDRLLHLWG-----RETPAKGSEGEQGPL-RHAASPSPQRQGGWSTDGGGR 378
              P          L+L       +  P    E   G L    AS   Q     ST G   
Sbjct: 894  QSPKPQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAG--- 950

Query: 379  LLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKP----SNSCVLR 434
                 PG   + GP        G P +Q   P + P   G     G  P     +  V +
Sbjct: 951  ----QPGPHSQSGP--------GAPMKQAPAPSQPPTSQGPPKSTGQAPPAPAKSIPVKK 998

Query: 435  ETMVQASP--SSKAQQTPSAQ 453
            ET   A+     KA+Q P+ +
Sbjct: 999  ETKAPAAEKLEPKAEQAPTVK 1019


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 77/339 (22%), Positives = 118/339 (34%), Gaps = 32/339 (9%)

Query: 412  EGPQQSGSLPEEGSKPSNSCVLRETM---VQASPSSKAQQTPSAQDYGRGNIISPSRMLD 468
            E  + +     EG     S  + E +   +Q S SS    +PS+         SP +   
Sbjct: 996  EDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPR-----TSPCQSPT 1050

Query: 469  KSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAP 528
             S  P       PS A S   GPP +++  I   P   + +      L   RP       
Sbjct: 1051 ISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVA 1110

Query: 529  QPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQ 588
             P+    P   P   G  Q  P      PG +   +    +P    +  APQ   R SA 
Sbjct: 1111 PPTRPAPPQRPPPPSGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAG 1170

Query: 589  ALFPFEASLLTSVARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRP 648
             L P   S  +  +     +  + +    + + A  P+S+L PP    +    P+A   P
Sbjct: 1171 RLTPESQSKTSETS-----KGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMP 1225

Query: 649  -SLVRQDAYTRSDSEPSKHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSDEEGG 707
             S  + +  T     P   S+   P   S  P+      SD      G RES    +   
Sbjct: 1226 QSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQVKTNGISD------GKRESPLKIDPFE 1279

Query: 708  AQSRDCDLALGYVAAGHAELAWTQEAPVSSGPLLSPVPK 746
                  DL+   +A   A+L+      V + P+ +P PK
Sbjct: 1280 ------DLSFNLLAVSKAQLS------VQTSPVPTPDPK 1306


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 60/216 (27%), Positives = 78/216 (36%), Gaps = 39/216 (18%)

Query: 296 PQRGGPSFP-RESPRG---------PAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRET 345
           PQR GP    R  P+G         PAG    Q  P   + P +  +         GR++
Sbjct: 474 PQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQS 533

Query: 346 -PAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQ 404
            P  G  G     R  ASPSPQRQ G       +  V  P       P ++ GA  GG Q
Sbjct: 534 RPVAGGPGAPPAARPPASPSPQRQAG-PPQATRQTSVSGP------APPKASGAPPGGQQ 586

Query: 405 QQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPS 464
           +QG  P + P  +G        P+        + +  P +  Q  PS    G G    P 
Sbjct: 587 RQG-PPQKPPGPAG--------PTRQASQAGPVPRTGPPTTQQPRPS----GPGPAGRPK 633

Query: 465 RMLDKSPS--------PASGHFAHPSFAASLKMGPP 492
             L + PS         A+G   HP   AS     P
Sbjct: 634 PQLAQKPSQDVPPPATAAAGGPPHPQLKASPAQAQP 669



 Score = 37.4 bits (85), Expect = 0.053
 Identities = 60/230 (26%), Positives = 82/230 (35%), Gaps = 40/230 (17%)

Query: 356 PLRHAASPSPQRQGGWSTDGGGRL-LVFAPGREDEGGPAQSRGAGRGGPQQQGYMP-LEG 413
           P +     SP R     T   G L L     ++  G PAQ R   +GGP Q G  P  +G
Sbjct: 419 PRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQG 478

Query: 414 PQQSGSLPEEGSK------PSNSCVLRETMVQASPSSKAQQ-----TPSAQDYGRGNIIS 462
           P      P +G +      P     L + +   SP+S  QQ      P  Q  GR     
Sbjct: 479 PPLQQRPPPQGQQHLSGLGPPAGSPLPQRL--PSPTSAPQQPASQAAPPTQGQGR----- 531

Query: 463 PSRMLDKSPS--PASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDR 520
            SR +   P   PA+   A PS     + GPP++  +     P                 
Sbjct: 532 QSRPVAGGPGAPPAARPPASPS--PQRQAGPPQATRQTSVSGPAP--------------- 574

Query: 521 PEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTLYPMP 570
           P+ + A P       P   P G  G  R+ + A   P R+   +T  P P
Sbjct: 575 PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVP-RTGPPTTQQPRP 623


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 59/214 (27%), Positives = 78/214 (36%), Gaps = 36/214 (16%)

Query: 296 PQRGGPSFP-RESPRG---------PAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRET 345
           PQR GP    R  P+G         PAG    Q  P   + P +  +         GR++
Sbjct: 474 PQRQGPPLQQRPPPQGQQHLSGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQS 533

Query: 346 -PAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQ 404
            P  G  G     R  ASPSPQRQ G       +  V  P       P ++ GA  GG Q
Sbjct: 534 RPVAGGPGAPPAARPPASPSPQRQAG-PPQATRQTSVSGP------APPKASGAPPGGQQ 586

Query: 405 QQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPS 464
           +QG  P + P  +G        P+        + +  P +  Q  PS    G G    P 
Sbjct: 587 RQG-PPQKPPGPAG--------PTRQASQAGPVPRTGPPTTQQPRPS----GPGPAGRPK 633

Query: 465 RMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEK 498
             L + PS        P  A +   GPP  +  K
Sbjct: 634 PQLAQKPSQDV-----PPPATAAAGGPPHPQLNK 662



 Score = 37.4 bits (85), Expect = 0.053
 Identities = 60/230 (26%), Positives = 82/230 (35%), Gaps = 40/230 (17%)

Query: 356 PLRHAASPSPQRQGGWSTDGGGRL-LVFAPGREDEGGPAQSRGAGRGGPQQQGYMP-LEG 413
           P +     SP R     T   G L L     ++  G PAQ R   +GGP Q G  P  +G
Sbjct: 419 PRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQG 478

Query: 414 PQQSGSLPEEGSK------PSNSCVLRETMVQASPSSKAQQ-----TPSAQDYGRGNIIS 462
           P      P +G +      P     L + +   SP+S  QQ      P  Q  GR     
Sbjct: 479 PPLQQRPPPQGQQHLSGLGPPAGSPLPQRL--PSPTSAPQQPASQAAPPTQGQGR----- 531

Query: 463 PSRMLDKSPS--PASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDR 520
            SR +   P   PA+   A PS     + GPP++  +     P                 
Sbjct: 532 QSRPVAGGPGAPPAARPPASPS--PQRQAGPPQATRQTSVSGPAP--------------- 574

Query: 521 PEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTLYPMP 570
           P+ + A P       P   P G  G  R+ + A   P R+   +T  P P
Sbjct: 575 PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVP-RTGPPTTQQPRP 623


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 132/614 (21%), Positives = 200/614 (32%), Gaps = 90/614 (14%)

Query: 162  AQAHKARPSMGDWRPRSVDETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGD 221
            A A  A   +G   PR     T PA    A   G + P     + +   +   +      
Sbjct: 575  ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 634

Query: 222  LDRALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHA 281
            + +A     GLQ  +A   + G L QG    L    P      V+Q   E          
Sbjct: 635  VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVL----PGKTGPTVTQVKAEKQ-------- 682

Query: 282  VALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLW 341
                       +++      S   E+   PA + T       +A PA ARA         
Sbjct: 683  -----------EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--------- 722

Query: 342  GRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGR- 400
                 AKG+    G +  AA+ + QR             V  P R  +     +RG    
Sbjct: 723  ---PSAKGTISAPGKVVTAAAQAKQRSPS---------KVKPPVRNPQNSTVLARGPASV 770

Query: 401  ---GGPQQQGYMPLEGPQQ-SGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
               G           GP++ SGS  EE      +    ET+ Q  PS K  Q  +A    
Sbjct: 771  PSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA----ETLAQVKPSGKTHQIRAALAPA 826

Query: 457  RGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIK---RSPMDKVLRFARQ 513
            +    SP +    +P   +G    PS A + K     S +E+      +P         +
Sbjct: 827  KE---SPRKGAAPTPPGKTG----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 879

Query: 514  PLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCS-----ESTLYP 568
            P L+   P  + A P  +    PA     +     R A A E+  RS S     E  +  
Sbjct: 880  PPLIFVDPNRSPAGPAAT----PAQ---AQAASTPRKARASESTARSSSSESEDEDVIPA 932

Query: 569  MPVLVP-----LAVAPQESHRTSAQALFPFEASLLTSVARRKHRRWQSTVEISARARLAS 623
               L P     +   P    R + +A     +S   S      ++ +      ++   AS
Sbjct: 933  TQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPAS 992

Query: 624  CP--ESNLGPPRPVARRAGGPLARGRPSLVRQDAY-TRSDSEPSKHSAECD-------PR 673
             P  ++ L      A  A  P+AR +PS     A  T   + P   S +         P+
Sbjct: 993  LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK 1052

Query: 674  FPSVIPETSEGESSDHTTNRFGDRESSSSDEEGGAQSRDCDLALGYVAAGHAELAWTQEA 733
             P V   T   ESSD + +       S  D EG   ++     +G   +    L     A
Sbjct: 1053 LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAA 1112

Query: 734  PVSSGPLLSPVPKL 747
              S   +++P   L
Sbjct: 1113 ESSEDDVVAPSQSL 1126


>gi|98985810 alpha 1 type XI collagen isoform B preproprotein [Homo
            sapiens]
          Length = 1818

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 73/264 (27%), Positives = 92/264 (34%), Gaps = 46/264 (17%)

Query: 193  EEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGLLCQGVDIP 252
            + G   P     A  P G   P+  S GD     P + G Q         G        P
Sbjct: 893  QRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPG--------P 944

Query: 253  LHVPDPKYRQDLVSQGGR--------EVYPYPSPLHAVALQSPLFVLTKETP---QRGGP 301
               P P  +  L    G+        +  P P P   V  Q P    T ET    +RG P
Sbjct: 945  KGPPGPPGKDGLPGHPGQRGETGFQGKTGP-PGPGGVVGPQGP----TGETGPIGERGHP 999

Query: 302  SFP----RESPRGPAGLNTIQTGPVLEA-----GPARARAYIDRLLHLWGRETPA-KGSE 351
              P     +   G AG    +  P  +      GPA  R +         +  P  KG E
Sbjct: 1000 GPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGE 1059

Query: 352  GEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA-GRGGPQ------ 404
            G QGP     SP  +   G +   G   L   PG +   GPA  +GA G  GPQ      
Sbjct: 1060 GPQGPPGPVGSPGERGSAGTAGPIG---LPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRD 1116

Query: 405  -QQGYMPLEGPQ-QSGSLPEEGSK 426
              QG + L GP   +GS  E+G K
Sbjct: 1117 GVQGPVGLPGPAGPAGSPGEDGDK 1140



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 37/135 (27%), Positives = 52/135 (38%), Gaps = 21/135 (15%)

Query: 306 ESPRGPAGLNTIQTGPVLEAGPA-----RARAYIDRLLHLWGRETPA--------KGSEG 352
           + P GP G    + GP  + GP+     + +  +  L    GR+ P          G+ G
Sbjct: 822 DGPEGPKG----RAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANG 877

Query: 353 EQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLE 412
           E+G    A  P P+ Q G +   G R    A G   + GP  + G G G P   G    +
Sbjct: 878 EKGARGVAGKPGPRGQRGPTGPRGSR---GARGPTGKPGPKGTSG-GDGPPGPPGERGPQ 933

Query: 413 GPQQSGSLPEEGSKP 427
           GPQ     P     P
Sbjct: 934 GPQGPVGFPGPKGPP 948



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 6/73 (8%)

Query: 4   PGGPPGSAGWDRRR-----LGARLRAAFAGLQELQGLRATQQERVRGALA-LQPPPAPAA 57
           P GPPG  G D  R     +G R     AG + L G R T     +  +A +  PP P  
Sbjct: 632 PQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKG 691

Query: 58  PCGPHGLHGPEQQ 70
             GP G  GP  Q
Sbjct: 692 NMGPQGEPGPPGQ 704



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 45/170 (26%), Positives = 60/170 (35%), Gaps = 40/170 (23%)

Query: 256  PDPKYRQDLVSQGGRE-VYPYPSPLHAVALQSPLFVLTKETPQRG--------GPSFPRE 306
            P P+ +Q +  Q G E    +P P   + LQ     L     ++G        GP  P  
Sbjct: 1182 PGPRGQQGMFGQKGDEGARGFPGPPGPIGLQG----LPGPPGEKGENGDVGPMGPPGP-P 1236

Query: 307  SPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQ 366
             PRGP G N    GP    GP  +   +              G  GE+G    A +P P 
Sbjct: 1237 GPRGPQGPNGAD-GP---QGPPGSVGSV--------------GGVGEKGEPGEAGNPGPP 1278

Query: 367  RQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGP 414
             + G     G R      G + E GP  + G    +G P   G     GP
Sbjct: 1279 GEAGVGGPKGER------GEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGP 1322



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 36/120 (30%), Positives = 43/120 (35%), Gaps = 9/120 (7%)

Query: 300 GPSFPR--ESPRGPAGLNTIQTGPVLEAG---PARARAYIDRLLHLWGRETPAKGSEGEQ 354
           GP  PR  + P GP G    +  P  + G   P    A  DR           KG  GE+
Sbjct: 571 GPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGER 630

Query: 355 GPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGP 414
           GP      P      G   + G R L   PG     G    RG   G P Q G   ++GP
Sbjct: 631 GPQGPPGPPGDDGMRGEDGEIGPRGL---PGEAGPRGLLGPRGT-PGAPGQPGMAGVDGP 686



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 50/201 (24%), Positives = 67/201 (33%), Gaps = 32/201 (15%)

Query: 300  GPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRH 359
            G   P+ +P GP G      GP  E GPA               +    G +GE G    
Sbjct: 1312 GDDGPKGNP-GPVGFPG-DPGPPGEPGPAG--------------QDGVGGDKGEDGDPGQ 1355

Query: 360  AASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGPQQS 417
               P P  + G     G R    A G E   G   ++G     G P + G +  +GP  +
Sbjct: 1356 PGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGP--A 1413

Query: 418  GSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGH 477
            G    EG +     V      Q  P +  Q  P       G +  P     K    + G 
Sbjct: 1414 GKPGPEGLRGIPGPVGE----QGLPGAAGQDGPP------GPMGPPGLPGLKGDPGSKGE 1463

Query: 478  FAHPSFAASLKMGPPKSKAEK 498
              HP     +  GPP  + EK
Sbjct: 1464 KGHPGLIGLI--GPPGEQGEK 1482


>gi|98985808 alpha 1 type XI collagen isoform C preproprotein [Homo
            sapiens]
          Length = 1767

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 73/264 (27%), Positives = 92/264 (34%), Gaps = 46/264 (17%)

Query: 193  EEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGLLCQGVDIP 252
            + G   P     A  P G   P+  S GD     P + G Q         G        P
Sbjct: 842  QRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPG--------P 893

Query: 253  LHVPDPKYRQDLVSQGGR--------EVYPYPSPLHAVALQSPLFVLTKETP---QRGGP 301
               P P  +  L    G+        +  P P P   V  Q P    T ET    +RG P
Sbjct: 894  KGPPGPPGKDGLPGHPGQRGETGFQGKTGP-PGPGGVVGPQGP----TGETGPIGERGHP 948

Query: 302  SFP----RESPRGPAGLNTIQTGPVLEA-----GPARARAYIDRLLHLWGRETPA-KGSE 351
              P     +   G AG    +  P  +      GPA  R +         +  P  KG E
Sbjct: 949  GPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGE 1008

Query: 352  GEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA-GRGGPQ------ 404
            G QGP     SP  +   G +   G   L   PG +   GPA  +GA G  GPQ      
Sbjct: 1009 GPQGPPGPVGSPGERGSAGTAGPIG---LPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRD 1065

Query: 405  -QQGYMPLEGPQ-QSGSLPEEGSK 426
              QG + L GP   +GS  E+G K
Sbjct: 1066 GVQGPVGLPGPAGPAGSPGEDGDK 1089



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 37/135 (27%), Positives = 52/135 (38%), Gaps = 21/135 (15%)

Query: 306 ESPRGPAGLNTIQTGPVLEAGPA-----RARAYIDRLLHLWGRETPA--------KGSEG 352
           + P GP G    + GP  + GP+     + +  +  L    GR+ P          G+ G
Sbjct: 771 DGPEGPKG----RAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANG 826

Query: 353 EQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLE 412
           E+G    A  P P+ Q G +   G R    A G   + GP  + G G G P   G    +
Sbjct: 827 EKGARGVAGKPGPRGQRGPTGPRGSR---GARGPTGKPGPKGTSG-GDGPPGPPGERGPQ 882

Query: 413 GPQQSGSLPEEGSKP 427
           GPQ     P     P
Sbjct: 883 GPQGPVGFPGPKGPP 897



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 6/73 (8%)

Query: 4   PGGPPGSAGWDRRR-----LGARLRAAFAGLQELQGLRATQQERVRGALA-LQPPPAPAA 57
           P GPPG  G D  R     +G R     AG + L G R T     +  +A +  PP P  
Sbjct: 581 PQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKG 640

Query: 58  PCGPHGLHGPEQQ 70
             GP G  GP  Q
Sbjct: 641 NMGPQGEPGPPGQ 653



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 45/170 (26%), Positives = 60/170 (35%), Gaps = 40/170 (23%)

Query: 256  PDPKYRQDLVSQGGRE-VYPYPSPLHAVALQSPLFVLTKETPQRG--------GPSFPRE 306
            P P+ +Q +  Q G E    +P P   + LQ     L     ++G        GP  P  
Sbjct: 1131 PGPRGQQGMFGQKGDEGARGFPGPPGPIGLQG----LPGPPGEKGENGDVGPMGPPGP-P 1185

Query: 307  SPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQ 366
             PRGP G N    GP    GP  +   +              G  GE+G    A +P P 
Sbjct: 1186 GPRGPQGPNGAD-GP---QGPPGSVGSV--------------GGVGEKGEPGEAGNPGPP 1227

Query: 367  RQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGP 414
             + G     G R      G + E GP  + G    +G P   G     GP
Sbjct: 1228 GEAGVGGPKGER------GEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGP 1271



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 36/120 (30%), Positives = 43/120 (35%), Gaps = 9/120 (7%)

Query: 300 GPSFPR--ESPRGPAGLNTIQTGPVLEAG---PARARAYIDRLLHLWGRETPAKGSEGEQ 354
           GP  PR  + P GP G    +  P  + G   P    A  DR           KG  GE+
Sbjct: 520 GPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGER 579

Query: 355 GPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGP 414
           GP      P      G   + G R L   PG     G    RG   G P Q G   ++GP
Sbjct: 580 GPQGPPGPPGDDGMRGEDGEIGPRGL---PGEAGPRGLLGPRGT-PGAPGQPGMAGVDGP 635



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 50/201 (24%), Positives = 67/201 (33%), Gaps = 32/201 (15%)

Query: 300  GPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRH 359
            G   P+ +P GP G      GP  E GPA               +    G +GE G    
Sbjct: 1261 GDDGPKGNP-GPVGFPG-DPGPPGEPGPAG--------------QDGVGGDKGEDGDPGQ 1304

Query: 360  AASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGPQQS 417
               P P  + G     G R    A G E   G   ++G     G P + G +  +GP  +
Sbjct: 1305 PGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGP--A 1362

Query: 418  GSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGH 477
            G    EG +     V      Q  P +  Q  P       G +  P     K    + G 
Sbjct: 1363 GKPGPEGLRGIPGPVGE----QGLPGAAGQDGPP------GPMGPPGLPGLKGDPGSKGE 1412

Query: 478  FAHPSFAASLKMGPPKSKAEK 498
              HP     +  GPP  + EK
Sbjct: 1413 KGHPGLIGLI--GPPGEQGEK 1431


>gi|98985806 alpha 1 type XI collagen isoform A preproprotein [Homo
            sapiens]
          Length = 1806

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 73/264 (27%), Positives = 92/264 (34%), Gaps = 46/264 (17%)

Query: 193  EEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGLLCQGVDIP 252
            + G   P     A  P G   P+  S GD     P + G Q         G        P
Sbjct: 881  QRGPTGPRGSRGARGPTGKPGPKGTSGGDGPPGPPGERGPQGPQGPVGFPG--------P 932

Query: 253  LHVPDPKYRQDLVSQGGR--------EVYPYPSPLHAVALQSPLFVLTKETP---QRGGP 301
               P P  +  L    G+        +  P P P   V  Q P    T ET    +RG P
Sbjct: 933  KGPPGPPGKDGLPGHPGQRGETGFQGKTGP-PGPGGVVGPQGP----TGETGPIGERGHP 987

Query: 302  SFP----RESPRGPAGLNTIQTGPVLEA-----GPARARAYIDRLLHLWGRETPA-KGSE 351
              P     +   G AG    +  P  +      GPA  R +         +  P  KG E
Sbjct: 988  GPPGPPGEQGLPGAAGKEGAKGDPGPQGISGKDGPAGLRGFPGERGLPGAQGAPGLKGGE 1047

Query: 352  GEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA-GRGGPQ------ 404
            G QGP     SP  +   G +   G   L   PG +   GPA  +GA G  GPQ      
Sbjct: 1048 GPQGPPGPVGSPGERGSAGTAGPIG---LPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRD 1104

Query: 405  -QQGYMPLEGPQ-QSGSLPEEGSK 426
              QG + L GP   +GS  E+G K
Sbjct: 1105 GVQGPVGLPGPAGPAGSPGEDGDK 1128



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 37/135 (27%), Positives = 52/135 (38%), Gaps = 21/135 (15%)

Query: 306 ESPRGPAGLNTIQTGPVLEAGPA-----RARAYIDRLLHLWGRETPA--------KGSEG 352
           + P GP G    + GP  + GP+     + +  +  L    GR+ P          G+ G
Sbjct: 810 DGPEGPKG----RAGPTGDPGPSGQAGEKGKLGVPGLPGYPGRQGPKGSTGFPGFPGANG 865

Query: 353 EQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLE 412
           E+G    A  P P+ Q G +   G R    A G   + GP  + G G G P   G    +
Sbjct: 866 EKGARGVAGKPGPRGQRGPTGPRGSR---GARGPTGKPGPKGTSG-GDGPPGPPGERGPQ 921

Query: 413 GPQQSGSLPEEGSKP 427
           GPQ     P     P
Sbjct: 922 GPQGPVGFPGPKGPP 936



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 26/73 (35%), Positives = 31/73 (42%), Gaps = 6/73 (8%)

Query: 4   PGGPPGSAGWDRRR-----LGARLRAAFAGLQELQGLRATQQERVRGALA-LQPPPAPAA 57
           P GPPG  G D  R     +G R     AG + L G R T     +  +A +  PP P  
Sbjct: 620 PQGPPGPPGDDGMRGEDGEIGPRGLPGEAGPRGLLGPRGTPGAPGQPGMAGVDGPPGPKG 679

Query: 58  PCGPHGLHGPEQQ 70
             GP G  GP  Q
Sbjct: 680 NMGPQGEPGPPGQ 692



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 45/170 (26%), Positives = 60/170 (35%), Gaps = 40/170 (23%)

Query: 256  PDPKYRQDLVSQGGRE-VYPYPSPLHAVALQSPLFVLTKETPQRG--------GPSFPRE 306
            P P+ +Q +  Q G E    +P P   + LQ     L     ++G        GP  P  
Sbjct: 1170 PGPRGQQGMFGQKGDEGARGFPGPPGPIGLQG----LPGPPGEKGENGDVGPMGPPGP-P 1224

Query: 307  SPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQ 366
             PRGP G N    GP    GP  +   +              G  GE+G    A +P P 
Sbjct: 1225 GPRGPQGPNGAD-GP---QGPPGSVGSV--------------GGVGEKGEPGEAGNPGPP 1266

Query: 367  RQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGP 414
             + G     G R      G + E GP  + G    +G P   G     GP
Sbjct: 1267 GEAGVGGPKGER------GEKGEAGPPGAAGPPGAKGPPGDDGPKGNPGP 1310



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 36/120 (30%), Positives = 43/120 (35%), Gaps = 9/120 (7%)

Query: 300 GPSFPR--ESPRGPAGLNTIQTGPVLEAG---PARARAYIDRLLHLWGRETPAKGSEGEQ 354
           GP  PR  + P GP G    +  P  + G   P    A  DR           KG  GE+
Sbjct: 559 GPQGPRGVQGPPGPTGKPGKRGRPGADGGRGMPGEPGAKGDRGFDGLPGLPGDKGHRGER 618

Query: 355 GPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGP 414
           GP      P      G   + G R L   PG     G    RG   G P Q G   ++GP
Sbjct: 619 GPQGPPGPPGDDGMRGEDGEIGPRGL---PGEAGPRGLLGPRGT-PGAPGQPGMAGVDGP 674



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 50/201 (24%), Positives = 67/201 (33%), Gaps = 32/201 (15%)

Query: 300  GPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRH 359
            G   P+ +P GP G      GP  E GPA               +    G +GE G    
Sbjct: 1300 GDDGPKGNP-GPVGFPG-DPGPPGEPGPAG--------------QDGVGGDKGEDGDPGQ 1343

Query: 360  AASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGPQQS 417
               P P  + G     G R    A G E   G   ++G     G P + G +  +GP  +
Sbjct: 1344 PGPPGPSGEAGPPGPPGKRGPPGAAGAEGRQGEKGAKGEAGAEGPPGKTGPVGPQGP--A 1401

Query: 418  GSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASGH 477
            G    EG +     V      Q  P +  Q  P       G +  P     K    + G 
Sbjct: 1402 GKPGPEGLRGIPGPVGE----QGLPGAAGQDGPP------GPMGPPGLPGLKGDPGSKGE 1451

Query: 478  FAHPSFAASLKMGPPKSKAEK 498
              HP     +  GPP  + EK
Sbjct: 1452 KGHPGLIGLI--GPPGEQGEK 1470


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 1487

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 43/134 (32%), Positives = 49/134 (36%), Gaps = 20/134 (14%)

Query: 299 GGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLR 358
           G P FP   PRGP G     TGP+   G                 E    G +GEQGP  
Sbjct: 429 GAPGFP--GPRGPPGPQGA-TGPLGPKGQTG--------------EPGIAGFKGEQGPKG 471

Query: 359 HAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA--GRGGPQQQGYM-PLEGPQ 415
                 PQ   G + + G R     PG     GP   RGA   RG P Q G   P   P 
Sbjct: 472 EPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPG 531

Query: 416 QSGSLPEEGSKPSN 429
           + G     G K +N
Sbjct: 532 ERGPSGLAGPKGAN 545



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 26/111 (23%)

Query: 298 RGGPSFPRES-PRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGP 356
           RG P    E+ P GPAG           AGP  A             +  AKG +GE G 
Sbjct: 818 RGAPGERGETGPPGPAGF----------AGPPGADG-----------QPGAKGEQGEAGQ 856

Query: 357 LRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG----AGRGGP 403
              A +P PQ   G     G   +    G     GP  + G    AGR GP
Sbjct: 857 KGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGP 907



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 38/129 (29%), Positives = 48/129 (37%), Gaps = 33/129 (25%)

Query: 299 GGPSFPRESPR-GPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPL 357
           G   FP  + R GP G N    GP    GP+             G++ P KG+ G+ GP 
Sbjct: 894 GATGFPGAAGRVGPPGSNG-NPGPPGPPGPS-------------GKDGP-KGARGDSGPP 938

Query: 358 RHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA-GRGGPQ----QQGYMPLE 412
             A  P  Q   G             PG + E G     GA G  GPQ    Q+G + L 
Sbjct: 939 GRAGEPGLQGPAG------------PPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLP 986

Query: 413 GPQQSGSLP 421
           G +     P
Sbjct: 987 GQRGERGFP 995



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 7/65 (10%)

Query: 4   PGGPPGSAGWDRRRLGARLRAAFAGL--QELQGLRATQQERVRGALALQPPPAPAAPCGP 61
           P GPPG  G     LG    A  AG   ++  G +    +   G +  + PP PA   GP
Sbjct: 166 PPGPPGPPG-----LGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGP 220

Query: 62  HGLHG 66
            G  G
Sbjct: 221 QGFQG 225



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 32/104 (30%), Positives = 40/104 (38%), Gaps = 28/104 (26%)

Query: 308 PRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQR 367
           P GP GL     G     GPA A                A+G++G+ GP   A  P P  
Sbjct: 322 PMGPRGL----PGERGRTGPAGAAG--------------ARGNDGQPGP---AGPPGPVG 360

Query: 368 QGGWSTDGGGRLLVFAPGREDEGGPAQSRG-AGRGGPQQQGYMP 410
             G     G      APG + E GP  +RG  G  GP+ +   P
Sbjct: 361 PAGGPGFPG------APGAKGEAGPTGARGPEGAQGPRGEPGTP 398



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 37/120 (30%), Positives = 44/120 (36%), Gaps = 22/120 (18%)

Query: 300 GPSFPRESPRGPAGLNTIQTGPVL--EAGPARARAYIDRLLHLWGRETPAKGSEGEQGPL 357
           GP+ P   P GPAG       P    EAGP                 T A+G EG QGP 
Sbjct: 351 GPAGP-PGPVGPAGGPGFPGAPGAKGEAGP-----------------TGARGPEGAQGPR 392

Query: 358 RHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGPQ 415
               +P      G S + G   +  A G     G A + G    RG P  QG     GP+
Sbjct: 393 GEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPK 452



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 27/80 (33%), Positives = 30/80 (37%), Gaps = 17/80 (21%)

Query: 4    PGGPPGSAGWDRRRLGARLR------AAFAGLQELQGLRATQQERV----------RGAL 47
            P GP G  G DR   GA+        A   G+Q  QG R  + E            RG  
Sbjct: 1078 PAGPTGKQG-DRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFT 1136

Query: 48   ALQPPPAPAAPCGPHGLHGP 67
             LQ  P P  P G  G  GP
Sbjct: 1137 GLQGLPGPPGPSGDQGASGP 1156



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 42/158 (26%), Positives = 53/158 (33%), Gaps = 34/158 (21%)

Query: 297 QRGGPSFPRE--SPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQ 354
           Q+G P   ++   P+GP G      GP  E GP   R          G   P +G +GE 
Sbjct: 105 QKGEPGDIKDIVGPKGPPG----PQGPAGEQGPRGDRGDKGEK----GAPGP-RGRDGEP 155

Query: 355 GPLRHAASPSP---------------QRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG-A 398
           G   +   P P               Q  GG+    GG  L    G     GP    G A
Sbjct: 156 GTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPA 215

Query: 399 GRGGPQ-------QQGYMPLEGPQQSGSLPEEGSKPSN 429
           G  GPQ       + G   + GP      P    KP +
Sbjct: 216 GAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGD 253


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 1418

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 43/134 (32%), Positives = 49/134 (36%), Gaps = 20/134 (14%)

Query: 299 GGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLR 358
           G P FP   PRGP G     TGP+   G                 E    G +GEQGP  
Sbjct: 360 GAPGFP--GPRGPPGPQGA-TGPLGPKGQTG--------------EPGIAGFKGEQGPKG 402

Query: 359 HAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA--GRGGPQQQGYM-PLEGPQ 415
                 PQ   G + + G R     PG     GP   RGA   RG P Q G   P   P 
Sbjct: 403 EPGPAGPQGAPGPAGEEGKRGARGEPGGVGPIGPPGERGAPGNRGFPGQDGLAGPKGAPG 462

Query: 416 QSGSLPEEGSKPSN 429
           + G     G K +N
Sbjct: 463 ERGPSGLAGPKGAN 476



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 34/111 (30%), Positives = 40/111 (36%), Gaps = 26/111 (23%)

Query: 298 RGGPSFPRES-PRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGP 356
           RG P    E+ P GPAG           AGP  A             +  AKG +GE G 
Sbjct: 749 RGAPGERGETGPPGPAGF----------AGPPGADG-----------QPGAKGEQGEAGQ 787

Query: 357 LRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG----AGRGGP 403
              A +P PQ   G     G   +    G     GP  + G    AGR GP
Sbjct: 788 KGDAGAPGPQGPSGAPGPQGPTGVTGPKGARGAQGPPGATGFPGAAGRVGP 838



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 38/129 (29%), Positives = 48/129 (37%), Gaps = 33/129 (25%)

Query: 299 GGPSFPRESPR-GPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPL 357
           G   FP  + R GP G N    GP    GP+             G++ P KG+ G+ GP 
Sbjct: 825 GATGFPGAAGRVGPPGSNG-NPGPPGPPGPS-------------GKDGP-KGARGDSGPP 869

Query: 358 RHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA-GRGGPQ----QQGYMPLE 412
             A  P  Q   G             PG + E G     GA G  GPQ    Q+G + L 
Sbjct: 870 GRAGEPGLQGPAG------------PPGEKGEPGDDGPSGAEGPPGPQGLAGQRGIVGLP 917

Query: 413 GPQQSGSLP 421
           G +     P
Sbjct: 918 GQRGERGFP 926



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 7/65 (10%)

Query: 4   PGGPPGSAGWDRRRLGARLRAAFAGL--QELQGLRATQQERVRGALALQPPPAPAAPCGP 61
           P GPPG  G     LG    A  AG   ++  G +    +   G +  + PP PA   GP
Sbjct: 97  PPGPPGPPG-----LGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPAGAPGP 151

Query: 62  HGLHG 66
            G  G
Sbjct: 152 QGFQG 156



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 32/104 (30%), Positives = 40/104 (38%), Gaps = 28/104 (26%)

Query: 308 PRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQR 367
           P GP GL     G     GPA A                A+G++G+ GP   A  P P  
Sbjct: 253 PMGPRGL----PGERGRTGPAGAAG--------------ARGNDGQPGP---AGPPGPVG 291

Query: 368 QGGWSTDGGGRLLVFAPGREDEGGPAQSRG-AGRGGPQQQGYMP 410
             G     G      APG + E GP  +RG  G  GP+ +   P
Sbjct: 292 PAGGPGFPG------APGAKGEAGPTGARGPEGAQGPRGEPGTP 329



 Score = 31.2 bits (69), Expect = 3.8
 Identities = 37/120 (30%), Positives = 44/120 (36%), Gaps = 22/120 (18%)

Query: 300 GPSFPRESPRGPAGLNTIQTGPVL--EAGPARARAYIDRLLHLWGRETPAKGSEGEQGPL 357
           GP+ P   P GPAG       P    EAGP                 T A+G EG QGP 
Sbjct: 282 GPAGP-PGPVGPAGGPGFPGAPGAKGEAGP-----------------TGARGPEGAQGPR 323

Query: 358 RHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG--AGRGGPQQQGYMPLEGPQ 415
               +P      G S + G   +  A G     G A + G    RG P  QG     GP+
Sbjct: 324 GEPGTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPK 383



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 27/80 (33%), Positives = 30/80 (37%), Gaps = 17/80 (21%)

Query: 4    PGGPPGSAGWDRRRLGARLR------AAFAGLQELQGLRATQQERV----------RGAL 47
            P GP G  G DR   GA+        A   G+Q  QG R  + E            RG  
Sbjct: 1009 PAGPTGKQG-DRGEAGAQGPMGPSGPAGARGIQGPQGPRGDKGEAGEPGERGLKGHRGFT 1067

Query: 48   ALQPPPAPAAPCGPHGLHGP 67
             LQ  P P  P G  G  GP
Sbjct: 1068 GLQGLPGPPGPSGDQGASGP 1087



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 42/158 (26%), Positives = 53/158 (33%), Gaps = 34/158 (21%)

Query: 297 QRGGPSFPRE--SPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQ 354
           Q+G P   ++   P+GP G      GP  E GP   R          G   P +G +GE 
Sbjct: 36  QKGEPGDIKDIVGPKGPPG----PQGPAGEQGPRGDRGDKGEK----GAPGP-RGRDGEP 86

Query: 355 GPLRHAASPSP---------------QRQGGWSTDGGGRLLVFAPGREDEGGPAQSRG-A 398
           G   +   P P               Q  GG+    GG  L    G     GP    G A
Sbjct: 87  GTPGNPGPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGGAQLGVMQGPMGPMGPRGPPGPA 146

Query: 399 GRGGPQ-------QQGYMPLEGPQQSGSLPEEGSKPSN 429
           G  GPQ       + G   + GP      P    KP +
Sbjct: 147 GAPGPQGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGD 184


>gi|188536004 zinc finger protein 469 [Homo sapiens]
          Length = 3925

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 73/320 (22%), Positives = 102/320 (31%), Gaps = 29/320 (9%)

Query: 349 GSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGY 408
           GS+G  G       P  +     S+ GG   L    G  D G      G  +      G 
Sbjct: 516 GSQGALGTAGKTPGPREKLPAVRSSQGGSPALFTYNGMTDPGAQPLFFGVAQPQVSPHGT 575

Query: 409 MPLEGPQQSGSLPEEGSKPSNSC-VLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRML 467
             L  P+  G+ P E   PS +      T    SP S +   PS+++      + PS   
Sbjct: 576 PSLPPPRVVGASPSESPLPSPATNTAGSTCSSLSPMSSSPANPSSEESQLPGPLGPSAFF 635

Query: 468 --DKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAH 525
                P      F  P    SL   P   + E  K  P       A      L+     H
Sbjct: 636 HPPTHPQETGSPFPSPEPPHSL---PTHYQPEPAKAFPFPADGLGAEGAFQCLEETPFPH 692

Query: 526 AAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGR--SCSESTLYPMPVLVPLAVAPQESH 583
             P+            GRGGLQ  P      P    S S ++L  + VL+      +   
Sbjct: 693 EGPE-----------VGRGGLQGFPRAPPPYPTHHFSLSSASLDQLDVLLTCRQCDRNYS 741

Query: 584 RTSAQALFPFEASLLTSVARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPL 643
             +A         LL + A+  H+R            L S P +    PR  A    G L
Sbjct: 742 SLAAFLAHRQFCGLLLARAKDGHQR------SPGPPGLPSPPAA----PRVPADAHAGLL 791

Query: 644 ARGRPSLVRQDAYTRSDSEP 663
           +  +  L+  DA      +P
Sbjct: 792 SHAKTFLLAGDAQAEGKDDP 811



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 54/228 (23%), Positives = 76/228 (33%), Gaps = 31/228 (13%)

Query: 284  LQSPLFVLTKETPQRGGP--SFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLW 341
            LQ    V +      GGP  +F + S   PAG  +        + P++A  +        
Sbjct: 3616 LQKEKEVSSSHMVSEGGPRGTFHKGSATKPAGCQSSSKDRSAASTPSKALKFPVHPRKAV 3675

Query: 342  GRETP---AKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGA 398
            G   P   A+G+E    P    A P P  QG                    G P      
Sbjct: 3676 GSLAPGELARGTENGMKPATPKAKPGPSSQGS-------------------GSPRPGTKT 3716

Query: 399  GRGGPQQQGYMPLEGPQQS--GSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
            G GG Q Q   P  G  QS   + P + S PS S        +A   S  +    A + G
Sbjct: 3717 G-GGSQPQ---PASGQLQSETATTPAKPSFPSRSPAPERLPARAQAKSCTKGPREAGEQG 3772

Query: 457  RGNIISPSRMLDKSPSPASGHFAHPSFAASL-KMGPPKSKAEKIKRSP 503
                + P    + S     G    P+ + S+   G   S  +K  R+P
Sbjct: 3773 PHGSLGPKEKGESSTKRKKGQVPGPARSESVGSFGRAPSAPDKPPRTP 3820



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 123/581 (21%), Positives = 187/581 (32%), Gaps = 109/581 (18%)

Query: 131  MSDGGSCSLSTSCASVCSDHISPSLGSLL---PVAQAHKARPSMGDWRPRSVD------- 180
            + D  +C+ S + A+    H+  SLG L    P+    +A+  +G   P S         
Sbjct: 2079 VGDLAACAPSPTSAA----HMPCSLGPLPREDPLTSPSRAQGGLGGQLPASPSCRDPPGP 2134

Query: 181  ---ETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASA 237
                   PAW P    +G +   +  D G       P  ++T   D   P +        
Sbjct: 2135 QQLLACSPAWAPLEEADGVQ---ATTDTGAEDSPVAPPSLTTSPCD---PKEA------- 2181

Query: 238  DAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHAVALQSPLFVLTKETPQ 297
               L G L QG   PL  P                +P P  + AV         + +TP+
Sbjct: 2182 ---LAGCLLQGEGSPLEDPSS--------------WP-PGSVSAVTCTH-----SGDTPK 2218

Query: 298  RGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRL-LHLWGRETPAKGSEGEQGP 356
                  P +S +       +   P     P  A A    + +   G  +   G E + G 
Sbjct: 2219 DSTLRIPEDSRK-----EKLWESPGRATSPPLAGAVSPSVAVRATGLSSTPTGDEAQAG- 2272

Query: 357  LRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQGYMPLEGPQQ 416
             R    P PQ +G        R+    P       P+ +   G    Q    +P E P  
Sbjct: 2273 -RGLPGPDPQSRGAPPHTNPDRM----PRGHSSYSPSNTARLGHREGQAVTAVPTEPPTL 2327

Query: 417  SGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDKSPSPASG 476
             G+ P+     S +C+  E       SSK  + P   + GR       R+   S     G
Sbjct: 2328 QGAGPD-----SPACLEGEM----GTSSKEPEDPGTPETGRSGATKMPRVTCPSTGLGLG 2378

Query: 477  HFAHPSFAAS-LKMGPPKSKAEKIKRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWD 535
                PS  AS  +   P+S      ++P    L     P  L  R  G    P  +   +
Sbjct: 2379 RTTAPSSTASDFQSDSPQSHRNASHQTPQGDPL----GPQDLKQRSRGYKKKPAST---E 2431

Query: 536  PAHW----PTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTSAQALF 591
               W    P G    +   A     PG S  ++  +      P   AP E    +  A  
Sbjct: 2432 NGQWKGQAPHGPVTCEVCAASFRSGPGLSRHKARKHR-----PHPGAPAEPSPAALPAQQ 2486

Query: 592  PFE--ASLLTSVARRKHRRWQSTVEISARARLASCPESNLGPPRPVARRAGGPLARGRPS 649
            P E  A       ++ HR       +S + R    P  + G P  V +    P A+G   
Sbjct: 2487 PLEPLAQKCQPPRKKSHR-------VSGKER----PNHSRGDPSHVTQ---PPPAQGSKE 2532

Query: 650  LVRQDAYTRSDS--EPSKHSAECDPRFPSVIPETSEGESSD 688
            ++R      S     PS    E D + P+  P   +    +
Sbjct: 2533 VLRAPGSPHSQQLHPPSPTEHEVDVKTPASKPRPDQAREDE 2573


>gi|91208423 thyroid receptor-interacting protein 6 [Homo sapiens]
          Length = 476

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 67/242 (27%), Positives = 87/242 (35%), Gaps = 43/242 (17%)

Query: 189 PQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLD--RALPADTG-LQKASADAELLGLL 245
           P  +E+  + PG  ED G  W        S G L   + LPAD G L+  S DAE+  L 
Sbjct: 48  PLPSEQCYQAPGGPEDRGPAWVG------SHGVLQHTQGLPADRGGLRPGSLDAEIDLLS 101

Query: 246 CQGVDIPLHVPDPKYRQDLVSQGGREVY-PYPSPLHAVALQSPLFVLTKETPQRGGPSFP 304
               ++         R D      R+ Y P P P +      P           GGP+  
Sbjct: 102 STLAELNGGRGHASRRPD------RQAYEPPPPPAYRTGSLKPNPASPLPASPYGGPT-- 153

Query: 305 RESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPS 364
                 PA   T  T     AGPA     +     + G   P +G+    GPL     P 
Sbjct: 154 ------PASYTTAST----PAGPAFP-VQVKVAQPVRGCGPPRRGASQASGPLPGPHFPL 202

Query: 365 PQRQGGWSTDGGGRLLVFAPG---REDEGGPAQSRGAGRGGPQQQGYMPLEGPQQSGSLP 421
           P           GR  V+ PG   + + G  A+   AG  GP  +G     GPQ   S P
Sbjct: 203 P-----------GRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGGEHGPQVPLSQP 251

Query: 422 EE 423
            E
Sbjct: 252 PE 253


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 40.8 bits (94), Expect = 0.005
 Identities = 68/270 (25%), Positives = 97/270 (35%), Gaps = 53/270 (19%)

Query: 189 PQATEEGARPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKASADAELLGLLCQG 248
           P  T+    PPG     G P     P  +  G      P   G+Q   +   L+GL  +G
Sbjct: 734 PPGTQGMQGPPGPRGMQGPPH----PHGIQGG------PGSQGIQGPVSQGPLMGLNPRG 783

Query: 249 VDIPLHVPDPKYRQDLVSQGGREVYPY-----PSPLHAVALQSPLFVLTKET-------P 296
           +  P   P P+  Q    QG    +P      P P   +    P  +   +        P
Sbjct: 784 MQGP---PGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPP 840

Query: 297 QRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEGEQGP 356
            +G    P +  RGP G  + Q  P    GP   +  +       G++ PA+G    QGP
Sbjct: 841 PQGSMLGPPQELRGPPGSQSQQGPPQGSLGPP-PQGGMQGPPGPQGQQNPARGPHPSQGP 899

Query: 357 L--RHAASP-------SPQRQGGWST------------DGGGRLLVFAPGREDEGGPAQS 395
           +  +   +P       +P  Q G ST               GR+    PG+    GP  +
Sbjct: 900 IPFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQ----GPGPN 955

Query: 396 RGAGRGGP-QQQGYMPLEGPQQSGSLPEEG 424
           +G  RG P    G M     +QSG  PE G
Sbjct: 956 KGDSRGPPNHHMGPMSERRHEQSGG-PEHG 984



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 66/281 (23%), Positives = 96/281 (34%), Gaps = 38/281 (13%)

Query: 274 PYPSPLHAVALQSPLFVLTKETPQRGGPSFPR-ESPRGPAGLNTIQT--GPVLEAGPARA 330
           P   PLH      P   +  + PQ      PR +   GP G+       GP+   GP   
Sbjct: 637 PQGPPLHQGG-GGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGP 695

Query: 331 RAYIDRLLHLWGRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEG 390
           +       H+       +G  G QG +     P PQ   G     G + +   PG     
Sbjct: 696 QGSSGPQGHMG-----PQGPPGPQGHIGPQGPPGPQGHLGPQGPPGTQGMQGPPGPRGMQ 750

Query: 391 GPAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTP 450
           GP    G  +GGP  QG   ++GP   G  P  G  P          +Q  P  +  Q P
Sbjct: 751 GPPHPHGI-QGGPGSQG---IQGPVSQG--PLMGLNPRG--------MQGPPGPRENQGP 796

Query: 451 SAQDYGRGNIISPSRMLDKSPSPASGHFAH-------PSFAASLKMGPPKSK----AEKI 499
           + Q    G+   P  M  + P P  G   H       P     ++  PP+       +++
Sbjct: 797 APQGMIMGH--PPQEM--RGPHPPGGLLGHGPQEMRGPQEIRGMQGPPPQGSMLGPPQEL 852

Query: 500 KRSPMDKVLRFARQPLLLLDRPEGAHAAPQPSLEWDPAHWP 540
           +  P  +  +   Q  L      G    P P  + +PA  P
Sbjct: 853 RGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGP 893


>gi|156151396 heterogeneous nuclear ribonucleoprotein R isoform 3
           [Homo sapiens]
          Length = 535

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/109 (32%), Positives = 48/109 (44%), Gaps = 19/109 (17%)

Query: 348 KGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQG 407
           +G  G   P R   +P P+ + G+S  G       AP     G P  SRG GRGGP QQ 
Sbjct: 408 RGGRGAPPPPRGRGAPPPRGRAGYSQRG-------AP----LGPPRGSRG-GRGGPAQQ- 454

Query: 408 YMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
                  +  GS    G++  N    R+      P SK +QT + Q++G
Sbjct: 455 ------QRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWG 497


>gi|156151394 heterogeneous nuclear ribonucleoprotein R isoform 1
           [Homo sapiens]
          Length = 636

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/109 (32%), Positives = 48/109 (44%), Gaps = 19/109 (17%)

Query: 348 KGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQG 407
           +G  G   P R   +P P+ + G+S  G       AP     G P  SRG GRGGP QQ 
Sbjct: 509 RGGRGAPPPPRGRGAPPPRGRAGYSQRG-------AP----LGPPRGSRG-GRGGPAQQ- 555

Query: 408 YMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
                  +  GS    G++  N    R+      P SK +QT + Q++G
Sbjct: 556 ------QRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWG 598


>gi|156151392 heterogeneous nuclear ribonucleoprotein R isoform 4
           [Homo sapiens]
          Length = 532

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/109 (32%), Positives = 48/109 (44%), Gaps = 19/109 (17%)

Query: 348 KGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQG 407
           +G  G   P R   +P P+ + G+S  G       AP     G P  SRG GRGGP QQ 
Sbjct: 405 RGGRGAPPPPRGRGAPPPRGRAGYSQRG-------AP----LGPPRGSRG-GRGGPAQQ- 451

Query: 408 YMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
                  +  GS    G++  N    R+      P SK +QT + Q++G
Sbjct: 452 ------QRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWG 494


>gi|5031755 heterogeneous nuclear ribonucleoprotein R isoform 2
           [Homo sapiens]
          Length = 633

 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/109 (32%), Positives = 48/109 (44%), Gaps = 19/109 (17%)

Query: 348 KGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGRGGPQQQG 407
           +G  G   P R   +P P+ + G+S  G       AP     G P  SRG GRGGP QQ 
Sbjct: 506 RGGRGAPPPPRGRGAPPPRGRAGYSQRG-------AP----LGPPRGSRG-GRGGPAQQ- 552

Query: 408 YMPLEGPQQSGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
                  +  GS    G++  N    R+      P SK +QT + Q++G
Sbjct: 553 ------QRGRGSRGSRGNRGGNVGGKRKADGYNQPDSKRRQTNNQQNWG 595


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 129/579 (22%), Positives = 191/579 (32%), Gaps = 92/579 (15%)

Query: 162  AQAHKARPSMGDWRPRSVDETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGD 221
            A A  A   +G   PR     T PA    A   G + P     + +   +   +      
Sbjct: 652  ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711

Query: 222  LDRALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHA 281
            + +A     GLQ  +A   + G L QG    L    P      V+Q   E          
Sbjct: 712  VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVL----PGKTGPTVTQVKAEKQ-------- 759

Query: 282  VALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLW 341
                       +++      S   E+   PA + T       +A PA ARA         
Sbjct: 760  -----------EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--------- 799

Query: 342  GRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGR- 400
                 AKG+    G +  AA+ + QR             V  P R  +     +RG    
Sbjct: 800  ---PSAKGTISAPGKVVTAAAQAKQRSPS---------KVKPPVRNPQNSTVLARGPASV 847

Query: 401  ---GGPQQQGYMPLEGPQQ-SGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
               G           GP++ SGS  EE      +    ET+ Q  PS K  Q  +A    
Sbjct: 848  PSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA----ETLAQVKPSGKTHQIRAALAPA 903

Query: 457  RGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIK---RSPMDKVLRFARQ 513
            +    SP +    +P   +G    PS A + K     S +E+      +P         +
Sbjct: 904  KE---SPRKGAAPTPPGKTG----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 956

Query: 514  PLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCS-----ESTLYP 568
            P L+   P  + A P  +    PA     +     R A A E+  RS S     E  +  
Sbjct: 957  PPLIFVDPNRSPAGPAAT----PAQ---AQAASTPRKARASESTARSSSSESEDEDVIPA 1009

Query: 569  MPVLVP-----LAVAPQESHRTSAQALFPFEASLLTSVARRKHRRWQSTVEISARARLAS 623
               L P     +   P    R + +A     +S   S      ++ +      ++   AS
Sbjct: 1010 TQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPAS 1069

Query: 624  CP--ESNLGPPRPVARRAGGPLARGRPSLVRQDAY-TRSDSEPSKHSAECD-------PR 673
             P  ++ L      A  A  P+AR +PS     A  T   + P   S +         P+
Sbjct: 1070 LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK 1129

Query: 674  FPSVIPETSEGESSDHTTNRFGDRESSSSDEEG--GAQS 710
             P V   T   ESSD + +       S  D EG  GA+S
Sbjct: 1130 LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKS 1168



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 67/300 (22%), Positives = 102/300 (34%), Gaps = 54/300 (18%)

Query: 324 EAGPARARAYI---DRLLHLWGRETPAKGSEGE---QGPLRHAASPSPQRQGGWSTDGG- 376
           E  PA  R+ +   +++L +     PAKG+ G+     P   A + + Q + G   +   
Sbjct: 281 EEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSE 340

Query: 377 -----------------GRLLVFAPGREDEGGPAQS-------RGAGRGGPQQQGYMPLE 412
                              L   A G+  + G A +       +GA    P + G  P  
Sbjct: 341 SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG--PAV 398

Query: 413 GPQQSGSLPEEGSKPSN-SCVLRETMVQASPSSKAQQT-----PSAQDYGRGNIISPSRM 466
              Q+G   E+    S  S    E   QA PS KA Q      P+ +   +G   +P R 
Sbjct: 399 AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458

Query: 467 LDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVLRFARQPLL-----LLDRP 521
               P+ A          +        S  E +      +V    + P +     +   P
Sbjct: 459 T--GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGP 516

Query: 522 EGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQE 581
            G  A P P  +  PA  P+ + G        WE    S SE +       VP AVAP +
Sbjct: 517 LGKGAGPVPPGKVGPAT-PSAQVG-------KWEEDSESSSEESSDSSDGEVPTAVAPAQ 568


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 129/579 (22%), Positives = 191/579 (32%), Gaps = 92/579 (15%)

Query: 162  AQAHKARPSMGDWRPRSVDETTVPAWRPQATEEGARPPGSVEDAGQPWGTFWPRPVSTGD 221
            A A  A   +G   PR     T PA    A   G + P     + +   +   +      
Sbjct: 575  ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 634

Query: 222  LDRALPADTGLQKASADAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYPYPSPLHA 281
            + +A     GLQ  +A   + G L QG    L    P      V+Q   E          
Sbjct: 635  VGQAKSVGKGLQVKAASVPVKGSLGQGTAPVL----PGKTGPTVTQVKAEKQ-------- 682

Query: 282  VALQSPLFVLTKETPQRGGPSFPRESPRGPAGLNTIQTGPVLEAGPARARAYIDRLLHLW 341
                       +++      S   E+   PA + T       +A PA ARA         
Sbjct: 683  -----------EDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARA--------- 722

Query: 342  GRETPAKGSEGEQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGGPAQSRGAGR- 400
                 AKG+    G +  AA+ + QR             V  P R  +     +RG    
Sbjct: 723  ---PSAKGTISAPGKVVTAAAQAKQRSPS---------KVKPPVRNPQNSTVLARGPASV 770

Query: 401  ---GGPQQQGYMPLEGPQQ-SGSLPEEGSKPSNSCVLRETMVQASPSSKAQQTPSAQDYG 456
               G           GP++ SGS  EE      +    ET+ Q  PS K  Q  +A    
Sbjct: 771  PSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA----ETLAQVKPSGKTHQIRAALAPA 826

Query: 457  RGNIISPSRMLDKSPSPASGHFAHPSFAASLKMGPPKSKAEKIK---RSPMDKVLRFARQ 513
            +    SP +    +P   +G    PS A + K     S +E+      +P         +
Sbjct: 827  KE---SPRKGAAPTPPGKTG----PSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIK 879

Query: 514  PLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCS-----ESTLYP 568
            P L+   P  + A P  +    PA     +     R A A E+  RS S     E  +  
Sbjct: 880  PPLIFVDPNRSPAGPAAT----PAQ---AQAASTPRKARASESTARSSSSESEDEDVIPA 932

Query: 569  MPVLVP-----LAVAPQESHRTSAQALFPFEASLLTSVARRKHRRWQSTVEISARARLAS 623
               L P     +   P    R + +A     +S   S      ++ +      ++   AS
Sbjct: 933  TQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPAS 992

Query: 624  CP--ESNLGPPRPVARRAGGPLARGRPSLVRQDAY-TRSDSEPSKHSAECD-------PR 673
             P  ++ L      A  A  P+AR +PS     A  T   + P   S +         P+
Sbjct: 993  LPLTQAALKVLAQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPK 1052

Query: 674  FPSVIPETSEGESSDHTTNRFGDRESSSSDEEG--GAQS 710
             P V   T   ESSD + +       S  D EG  GA+S
Sbjct: 1053 LPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKS 1091


>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
          Length = 1444

 Score = 40.0 bits (92), Expect = 0.008
 Identities = 65/269 (24%), Positives = 100/269 (37%), Gaps = 42/269 (15%)

Query: 467 LDKSPSPAS----GHFAHPSFAASLKMGPPKSKAEKIKRSPMDK-------VLRFARQPL 515
           L+K P+P      G  A    +++L+  P +++AE +    MD+       +    +Q L
Sbjct: 602 LEKRPNPEKVVEEGREAGEMESSTLQESP-RARAEAVLLHEMDEDDLANALIWPEIQQEL 660

Query: 516 LLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQRRPALAWEAPGRSCSESTLYPMPVLVPL 575
            +++  E   + P P+L+  P   P     L   P +  E PG     S  +P PV  PL
Sbjct: 661 KIIESEEELSSLPPPALKTSPIQ-PILESSLG--PFIPSEPPGSLPCGS--FPAPVSTPL 715

Query: 576 AVAPQESHRTSAQA---------------LFPFEASLLT-SVARRKHRRWQSTVEISARA 619
            V  ++    S Q                L P  ASL    +   +    Q+TVE+    
Sbjct: 716 EVWTRDPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGG-- 773

Query: 620 RLASCPESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSDSEPS-KHSAECDPRFPSVI 678
                   NL PP P A     PL    P L+ +    R DS    +     D       
Sbjct: 774 ------PGNLSPPLPPAPPPPTPLEESTPVLLSKGGPEREDSSRKLRTDLYIDQLKSQDS 827

Query: 679 PETSEGESSDHTTNRFGDRESSSSDEEGG 707
           PE S     +  T R  D+++S +    G
Sbjct: 828 PEISSLCQGEEATPRHSDKQNSKNAASEG 856


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,499,058
Number of Sequences: 37866
Number of extensions: 2323097
Number of successful extensions: 10068
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 353
Number of HSP's that attempted gapping in prelim test: 8776
Number of HSP's gapped (non-prelim): 1722
length of query: 774
length of database: 18,247,518
effective HSP length: 110
effective length of query: 664
effective length of database: 14,082,258
effective search space: 9350619312
effective search space used: 9350619312
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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