Guide to the Human Genome
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Search of human proteins with 16117781

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16117781 F-box and WD repeat domain containing 7 isoform 1
[Homo sapiens]
         (707 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H...  1447   0.0  
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H...  1118   0.0  
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H...  1117   0.0  
gi|48928050 F-box and WD repeat domain containing 11 isoform C [...   241   1e-63
gi|48928048 F-box and WD repeat domain containing 11 isoform A [...   241   1e-63
gi|48928046 F-box and WD repeat domain containing 11 isoform B [...   241   1e-63
gi|4502477 beta-transducin repeat containing protein isoform 2 [...   237   3e-62
gi|16117783 beta-transducin repeat containing protein isoform 1 ...   237   3e-62
gi|32189425 WD repeat domain 69 [Homo sapiens]                        184   3e-46
gi|16554629 WD repeat domain 5 [Homo sapiens]                         169   6e-42
gi|16554627 WD repeat domain 5 [Homo sapiens]                         169   6e-42
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   163   6e-40
gi|157266266 WD repeat domain 86 [Homo sapiens]                       162   8e-40
gi|23199987 WD repeat domain 5B [Homo sapiens]                        160   4e-39
gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]           134   2e-31
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            130   3e-30
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            130   3e-30
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...   125   1e-28
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]         125   1e-28
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...   122   9e-28
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]      122   1e-27
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    121   2e-27
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa...   120   4e-27
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    118   2e-26
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            116   6e-26
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   115   1e-25
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...   114   2e-25
gi|26665869 WD repeat domain 51B [Homo sapiens]                       114   4e-25
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         113   5e-25
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         113   5e-25

>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
           sapiens]
          Length = 707

 Score = 1447 bits (3747), Expect = 0.0
 Identities = 707/707 (100%), Positives = 707/707 (100%)

Query: 1   MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV 60
           MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV
Sbjct: 1   MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVV 60

Query: 61  GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ 120
           GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ
Sbjct: 61  GVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQ 120

Query: 121 ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS 180
           ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS
Sbjct: 121 ESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRS 180

Query: 181 FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM 240
           FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM
Sbjct: 181 FSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKM 240

Query: 241 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 300
           FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD
Sbjct: 241 FQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKD 300

Query: 301 LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR 360
           LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR
Sbjct: 301 LLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHR 360

Query: 361 IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 420
           IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH
Sbjct: 361 IDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGH 420

Query: 421 TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD 480
           TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD
Sbjct: 421 TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRD 480

Query: 481 ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH 540
           ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH
Sbjct: 481 ATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGH 540

Query: 541 TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD 600
           TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD
Sbjct: 541 TNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNAD 600

Query: 601 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 660
           STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL
Sbjct: 601 STVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNL 660

Query: 661 VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK 707
           VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
Sbjct: 661 VTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK 707


>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
           sapiens]
          Length = 627

 Score = 1118 bits (2892), Expect = 0.0
 Identities = 541/541 (100%), Positives = 541/541 (100%)

Query: 167 KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 226
           KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT
Sbjct: 87  KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 146

Query: 227 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 286
           SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
Sbjct: 147 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 206

Query: 287 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 346
           ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF
Sbjct: 207 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 266

Query: 347 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 406
           IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW
Sbjct: 267 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 326

Query: 407 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 466
           SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC
Sbjct: 327 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 386

Query: 467 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 526
           MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW
Sbjct: 387 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 446

Query: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
           DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG
Sbjct: 447 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 506

Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
           MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV
Sbjct: 507 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 566

Query: 647 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 706
           KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM
Sbjct: 567 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 626

Query: 707 K 707
           K
Sbjct: 627 K 627


>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
           sapiens]
          Length = 589

 Score = 1117 bits (2889), Expect = 0.0
 Identities = 540/541 (99%), Positives = 541/541 (100%)

Query: 167 KMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 226
           +MKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT
Sbjct: 49  RMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRIT 108

Query: 227 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 286
           SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK
Sbjct: 109 SVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPK 168

Query: 287 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 346
           ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF
Sbjct: 169 ELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGF 228

Query: 347 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 406
           IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW
Sbjct: 229 IHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVW 288

Query: 407 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 466
           SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC
Sbjct: 289 SAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRC 348

Query: 467 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 526
           MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW
Sbjct: 349 MHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVW 408

Query: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
           DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG
Sbjct: 409 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 468

Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
           MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV
Sbjct: 469 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 528

Query: 647 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 706
           KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM
Sbjct: 529 KLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDM 588

Query: 707 K 707
           K
Sbjct: 589 K 589


>gi|48928050 F-box and WD repeat domain containing 11 isoform C
           [Homo sapiens]
          Length = 542

 Score =  241 bits (616), Expect = 1e-63
 Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)

Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
           +K F  WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP++    +A  +L
Sbjct: 77  IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 136

Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
           S+L+ + L  A   C+ W+ +  + +LW++  +     +PL               K R 
Sbjct: 137 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 196

Query: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
              P   F  S +         I++NWR G     ++  +  +   + CLQ+   +I+SG
Sbjct: 197 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 256

Query: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
             DN++K+W   + +CL+ L GHTG V   Q  + +I++GS+D T++VW+  TGE ++TL
Sbjct: 257 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 316

Query: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
             H   V  +      +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D + +
Sbjct: 317 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 376

Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
           VS + D  +KVW   T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G C+
Sbjct: 377 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 436

Query: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
             L GH+ L   +   +  +VSG  D  +K+WD++            CL+TL    +H  
Sbjct: 437 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 493

Query: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
            V  LQF++  +I+SS D T+ +WD
Sbjct: 494 RVFRLQFDEFQIISSSHDDTILIWD 518



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)

Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
           ++  D  ++SG  D+++KIWD  + +CL+ L G   H  +V CLQ+++  ++T S D TV
Sbjct: 246 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 302

Query: 647 KLWDLKTGEFIRNLV 661
           ++WD+ TGE +  L+
Sbjct: 303 RVWDVNTGEVLNTLI 317



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)

Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
           LQ +Q  +++   V CLQ++   +I+   D ++K+WD  + E ++ L    +G +G V+
Sbjct: 230 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 284


>gi|48928048 F-box and WD repeat domain containing 11 isoform A
           [Homo sapiens]
          Length = 508

 Score =  241 bits (616), Expect = 1e-63
 Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)

Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
           +K F  WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP++    +A  +L
Sbjct: 43  IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 102

Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
           S+L+ + L  A   C+ W+ +  + +LW++  +     +PL               K R 
Sbjct: 103 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 162

Query: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
              P   F  S +         I++NWR G     ++  +  +   + CLQ+   +I+SG
Sbjct: 163 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 222

Query: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
             DN++K+W   + +CL+ L GHTG V   Q  + +I++GS+D T++VW+  TGE ++TL
Sbjct: 223 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 282

Query: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
             H   V  +      +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D + +
Sbjct: 283 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 342

Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
           VS + D  +KVW   T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G C+
Sbjct: 343 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 402

Query: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
             L GH+ L   +   +  +VSG  D  +K+WD++            CL+TL    +H  
Sbjct: 403 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 459

Query: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
            V  LQF++  +I+SS D T+ +WD
Sbjct: 460 RVFRLQFDEFQIISSSHDDTILIWD 484



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)

Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
           ++  D  ++SG  D+++KIWD  + +CL+ L G   H  +V CLQ+++  ++T S D TV
Sbjct: 212 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 268

Query: 647 KLWDLKTGEFIRNLV 661
           ++WD+ TGE +  L+
Sbjct: 269 RVWDVNTGEVLNTLI 283



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)

Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
           LQ +Q  +++   V CLQ++   +I+   D ++K+WD  + E ++ L    +G +G V+
Sbjct: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 250


>gi|48928046 F-box and WD repeat domain containing 11 isoform B
           [Homo sapiens]
          Length = 529

 Score =  241 bits (616), Expect = 1e-63
 Identities = 139/445 (31%), Positives = 230/445 (51%), Gaps = 35/445 (7%)

Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
           +K F  WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP++    +A  +L
Sbjct: 64  IKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENIL 123

Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH-------------IKRRK 340
           S+L+ + L  A   C+ W+ +  + +LW++  +     +PL               K R 
Sbjct: 124 SYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRP 183

Query: 341 VIKP--GFIHSPWKSAYIRQHRIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIVSG 397
              P   F  S +         I++NWR G     ++  +  +   + CLQ+   +I+SG
Sbjct: 184 TDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISG 243

Query: 398 SDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTL 457
             DN++K+W   + +CL+ L GHTG V   Q  + +I++GS+D T++VW+  TGE ++TL
Sbjct: 244 LRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTL 303

Query: 458 YGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGRRV 514
             H   V  +      +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D + +
Sbjct: 304 IHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYI 363

Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCI 574
           VS + D  +KVW   T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G C+
Sbjct: 364 VSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACL 423

Query: 575 HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKHQS 625
             L GH+ L   +   +  +VSG  D  +K+WD++            CL+TL    +H  
Sbjct: 424 RVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLV---EHSG 480

Query: 626 AVTCLQFNKNFVITSSDDGTVKLWD 650
            V  LQF++  +I+SS D T+ +WD
Sbjct: 481 RVFRLQFDEFQIISSSHDDTILIWD 505



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 28/75 (37%), Positives = 49/75 (65%), Gaps = 3/75 (4%)

Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
           ++  D  ++SG  D+++KIWD  + +CL+ L G   H  +V CLQ+++  ++T S D TV
Sbjct: 233 LQYDDEKIISGLRDNSIKIWDKTSLECLKVLTG---HTGSVLCLQYDERVIVTGSSDSTV 289

Query: 647 KLWDLKTGEFIRNLV 661
           ++WD+ TGE +  L+
Sbjct: 290 RVWDVNTGEVLNTLI 304



 Score = 33.5 bits (75), Expect = 0.70
 Identities = 17/59 (28%), Positives = 34/59 (57%), Gaps = 4/59 (6%)

Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
           LQ +Q  +++   V CLQ++   +I+   D ++K+WD  + E ++ L    +G +G V+
Sbjct: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVL----TGHTGSVL 271


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score =  237 bits (604), Expect = 3e-62
 Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)

Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
           +K F+ WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP      +A  +L
Sbjct: 102 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 161

Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 344
           S+L+ K L  A   C+ W  +  D +LW++  +     + L     +RR         KP
Sbjct: 162 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 221

Query: 345 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 395
              ++P  S Y   +         I++NWR G     ++  +      + CLQ+   +IV
Sbjct: 222 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 281

Query: 396 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 455
           SG  DNT+K+W   T +C R L GHTG V   Q  + +II+GS+D T++VW+  TGE ++
Sbjct: 282 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 341

Query: 456 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 512
           TL  H   V  +  +   +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D +
Sbjct: 342 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 401

Query: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 572
            +VS + D  +KVW+  T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G 
Sbjct: 402 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 461

Query: 573 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 623
           C+  L GH+ L   +   +  +VSG  D  +K+WD+             CL+TL    +H
Sbjct: 462 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 518

Query: 624 QSAVTCLQFNKNFVITSSDDGTVKLWD 650
              V  LQF++  +++SS D T+ +WD
Sbjct: 519 SGRVFRLQFDEFQIVSSSHDDTILIWD 545



 Score =  152 bits (385), Expect = 8e-37
 Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)

Query: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 513
           IH     +  V C+   ++++VSG RD T+++WD  T +C  +L GH  +V C+QYD R 
Sbjct: 260 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 319

Query: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 573
           +++G+ D  V+VWD  T   L+TL  H   V  L+F+   +V+ S D SI VWD+ +   
Sbjct: 320 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 379

Query: 574 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
           I     L GH++  + ++  D  +VS + D T+K+W+  T + ++TL G   H+  + CL
Sbjct: 380 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 436

Query: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
           Q+    V++ S D T++LWD++ G  +R L      G   +V  IR  N ++V      +
Sbjct: 437 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 485

Query: 691 GTEETKLLVLD 701
           G  + K+ V D
Sbjct: 486 GAYDGKIKVWD 496



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)

Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
           LQ +   ++    V CLQ++   +++   D T+K+WD  T E  R L    +G +G V+
Sbjct: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 311


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score =  237 bits (604), Expect = 3e-62
 Identities = 145/447 (32%), Positives = 231/447 (51%), Gaps = 37/447 (8%)

Query: 238 LKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKE----LALYVL 293
           +K F+ WS  +++  ++ LI      Q  H+   ++P  QRDFI+ LP      +A  +L
Sbjct: 138 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENIL 197

Query: 294 SFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLH---IKRRK------VIKP 344
           S+L+ K L  A   C+ W  +  D +LW++  +     + L     +RR         KP
Sbjct: 198 SYLDAKSLCAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKP 257

Query: 345 GFIHSPWKSAYIRQH--------RIDTNWRRGELKSPKV-LKGHDDHVITCLQFCGNRIV 395
              ++P  S Y   +         I++NWR G     ++  +      + CLQ+   +IV
Sbjct: 258 PDGNAPPNSFYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKGVYCLQYDDQKIV 317

Query: 396 SGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIH 455
           SG  DNT+K+W   T +C R L GHTG V   Q  + +II+GS+D T++VW+  TGE ++
Sbjct: 318 SGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNTGEMLN 377

Query: 456 TLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYDGR 512
           TL  H   V  +  +   +V+ S+D ++ VWD+ +   +    VL+GH AAV  V +D +
Sbjct: 378 TLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK 437

Query: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 572
            +VS + D  +KVW+  T   + TL GH   +  LQ+    VVSGS D +IR+WD+E G 
Sbjct: 438 YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGA 497

Query: 573 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG---------QCLQTLQGPNKH 623
           C+  L GH+ L   +   +  +VSG  D  +K+WD+             CL+TL    +H
Sbjct: 498 CLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLVAALDPRAPAGTLCLRTLV---EH 554

Query: 624 QSAVTCLQFNKNFVITSSDDGTVKLWD 650
              V  LQF++  +++SS D T+ +WD
Sbjct: 555 SGRVFRLQFDEFQIVSSSHDDTILIWD 581



 Score =  152 bits (385), Expect = 8e-37
 Identities = 84/251 (33%), Positives = 138/251 (54%), Gaps = 17/251 (6%)

Query: 454 IHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR 513
           IH     +  V C+   ++++VSG RD T+++WD  T +C  +L GH  +V C+QYD R 
Sbjct: 296 IHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERV 355

Query: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNC 573
           +++G+ D  V+VWD  T   L+TL  H   V  L+F+   +V+ S D SI VWD+ +   
Sbjct: 356 IITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTD 415

Query: 574 I---HTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
           I     L GH++  + ++  D  +VS + D T+K+W+  T + ++TL G   H+  + CL
Sbjct: 416 ITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNG---HKRGIACL 472

Query: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
           Q+    V++ S D T++LWD++ G  +R L      G   +V  IR  N ++V      +
Sbjct: 473 QYRDRLVVSGSSDNTIRLWDIECGACLRVL-----EGHEELVRCIRFDNKRIV------S 521

Query: 691 GTEETKLLVLD 701
           G  + K+ V D
Sbjct: 522 GAYDGKIKVWD 532



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 4/59 (6%)

Query: 614 LQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVV 672
           LQ +   ++    V CLQ++   +++   D T+K+WD  T E  R L    +G +G V+
Sbjct: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRIL----TGHTGSVL 347


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  184 bits (466), Expect = 3e-46
 Identities = 100/301 (33%), Positives = 172/301 (57%), Gaps = 17/301 (5%)

Query: 374 KVLKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD- 431
           KVLK H   +    L   G+  ++GS D T K+W   +G+ L TL GH   V++    + 
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 432 --NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWD 487
             + I +GS D+T K+W+ ETG+C HT  GHT+ + C+  + +   V +GS D T ++WD
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205

Query: 488 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
           I+ G+ ++ L GH A +  + ++  G R+++G++D  V VWD +T   ++ L GH   + 
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265

Query: 546 SLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGH--QSLTSGMELKDNILVSGNADS 601
           S  F  D   +++GS+D + ++WD   G C+ TLTGH  + L S  +    ++ + +AD 
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325

Query: 602 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLWDLKTGEFIRN 659
           T +I+   T +C+  L+G   H+  ++ + FN   N ++T S D T ++WD +TG+ ++ 
Sbjct: 326 TARIFSAATRKCIAKLEG---HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQV 382

Query: 660 L 660
           L
Sbjct: 383 L 383



 Score =  176 bits (447), Expect = 5e-44
 Identities = 101/300 (33%), Positives = 163/300 (54%), Gaps = 19/300 (6%)

Query: 365 WRRGELKSPKVLKGHDDHVITCLQF---CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHT 421
           W     +    L+GH + V+  + F    G++I +GS D T K+WS  TGKC  T  GHT
Sbjct: 119 WDTASGEELNTLEGHRN-VVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177

Query: 422 GGV--WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSG 477
             +   S   +  ++ +GS D T K+W+ + GE ++TL GH++ +  +  +    R+++G
Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237

Query: 478 SRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 535
           S D T+ VWD +TG+ +++L+GH A +    +  D   +++G+ D   K+WD     C+ 
Sbjct: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVA 297

Query: 536 TLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 591
           TL GH + +    FD  G  + + S D + R++   T  CI  L GH+   S +    + 
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357

Query: 592 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLW 649
           N L++G++D T +IWD +TGQCLQ L+G   H   +    FN   N VIT S D T ++W
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEG---HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score =  108 bits (269), Expect = 2e-23
 Identities = 60/175 (34%), Positives = 98/175 (56%), Gaps = 12/175 (6%)

Query: 496 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--- 550
           VL  H+  +  V  +  G   ++G+YD   K+WD  +   L+TL+GH N VY++ F+   
Sbjct: 87  VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPY 146

Query: 551 GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKIWDI 608
           G  + +GS D + ++W VETG C HT  GH +  +      +  ++ +G+ D+T K+WDI
Sbjct: 147 GDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDI 206

Query: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNF--VITSSDDGTVKLWDLKTGEFIRNLV 661
           + G+ + TL+G   H + +  L FN +   +IT S D TV +WD  TG  +  L+
Sbjct: 207 QNGEEVYTLRG---HSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILI 258


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  169 bits (429), Expect = 6e-42
 Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 446
           G  + S S D  +K+W A  GK  +T+ GH  G+    WSS    N+++S S D+TLK+W
Sbjct: 57  GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114

Query: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
           +  +G+C+ TL GH++ V C + + +   +VSGS D ++R+WD++TG+CL  L  H   V
Sbjct: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174

Query: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 559
             V +  DG  +VS +YD + ++WD  +  CL TL    N   S ++F  +G ++++ +L
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234

Query: 560 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 609
           D ++++WD   G C+ T TGH+          S+T G       +VSG+ D+ V IW+++
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289

Query: 610 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 649
           T + +Q LQG   H   V  T     +N + +++  +D T+KLW
Sbjct: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  145 bits (365), Expect = 2e-34
 Identities = 85/261 (32%), Positives = 141/261 (54%), Gaps = 19/261 (7%)

Query: 416 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHE 471
           TL GHT  V S +   N   + S S D+ +K+W A  G+   T+ GH   +         
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPE 529
             +VS S D TL++WD+ +G+CL  L GH   V C  ++ +   +VSG++D  V++WD +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159

Query: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG 586
           T  CL TL  H++ V ++ F  DG  +VS S D   R+WD  +G C+ TL    +   S 
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219

Query: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-----FVIT 639
           ++   N   +++   D+T+K+WD   G+CL+T  G   H++   C+  N +     ++++
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG---HKNEKYCIFANFSVTGGKWIVS 276

Query: 640 SSDDGTVKLWDLKTGEFIRNL 660
            S+D  V +W+L+T E ++ L
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKL 297



 Score =  107 bits (267), Expect = 4e-23
 Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)

Query: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
           L GH  AV  V++  +G  + S + D ++K+W         T+ GH   +  + +  D  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
            +VS S D ++++WDV +G C+ TL GH +         + N++VSG+ D +V+IWD+KT
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 611 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLV 661
           G+CL+TL     H   V+ + FN++   +++SS DG  ++WD  +G+ ++ L+
Sbjct: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  169 bits (429), Expect = 6e-42
 Identities = 98/284 (34%), Positives = 162/284 (57%), Gaps = 35/284 (12%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQMRDNIIISGSTDRTLKVW 446
           G  + S S D  +K+W A  GK  +T+ GH  G+    WSS    N+++S S D+TLK+W
Sbjct: 57  GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD--SNLLVSASDDKTLKIW 114

Query: 447 NAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAV 504
           +  +G+C+ TL GH++ V C + + +   +VSGS D ++R+WD++TG+CL  L  H   V
Sbjct: 115 DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV 174

Query: 505 RCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYS-LQF--DGIHVVSGSL 559
             V +  DG  +VS +YD + ++WD  +  CL TL    N   S ++F  +G ++++ +L
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATL 234

Query: 560 DTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDNILVSGNADSTVKIWDIK 609
           D ++++WD   G C+ T TGH+          S+T G       +VSG+ D+ V IW+++
Sbjct: 235 DNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG-----KWIVSGSEDNLVYIWNLQ 289

Query: 610 TGQCLQTLQGPNKHQSAV--TCLQFNKNFVITSS--DDGTVKLW 649
           T + +Q LQG   H   V  T     +N + +++  +D T+KLW
Sbjct: 290 TKEIVQKLQG---HTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  145 bits (365), Expect = 2e-34
 Identities = 85/261 (32%), Positives = 141/261 (54%), Gaps = 19/261 (7%)

Query: 416 TLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CMHLHE 471
           TL GHT  V S +   N   + S S D+ +K+W A  G+   T+ GH   +         
Sbjct: 40  TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99

Query: 472 KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKVWDPE 529
             +VS S D TL++WD+ +G+CL  L GH   V C  ++ +   +VSG++D  V++WD +
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVK 159

Query: 530 TETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL-TSG 586
           T  CL TL  H++ V ++ F  DG  +VS S D   R+WD  +G C+ TL    +   S 
Sbjct: 160 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSF 219

Query: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN-----FVIT 639
           ++   N   +++   D+T+K+WD   G+CL+T  G   H++   C+  N +     ++++
Sbjct: 220 VKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG---HKNEKYCIFANFSVTGGKWIVS 276

Query: 640 SSDDGTVKLWDLKTGEFIRNL 660
            S+D  V +W+L+T E ++ L
Sbjct: 277 GSEDNLVYIWNLQTKEIVQKL 297



 Score =  107 bits (267), Expect = 4e-23
 Identities = 56/173 (32%), Positives = 99/173 (57%), Gaps = 11/173 (6%)

Query: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
           L GH  AV  V++  +G  + S + D ++K+W         T+ GH   +  + +  D  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100

Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
            +VS S D ++++WDV +G C+ TL GH +         + N++VSG+ D +V+IWD+KT
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160

Query: 611 GQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRNLV 661
           G+CL+TL     H   V+ + FN++   +++SS DG  ++WD  +G+ ++ L+
Sbjct: 161 GKCLKTLPA---HSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  163 bits (412), Expect = 6e-40
 Identities = 99/291 (34%), Positives = 153/291 (52%), Gaps = 35/291 (12%)

Query: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW--SSQMRDNIIISGSTDRTLKVWNAETG 451
           +VS S+D T+KVW   TG   RTL GHT  V   S      ++ S S D T+K+W+ +  
Sbjct: 123 MVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGF 182

Query: 452 ECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQ- 508
           ECI T++GH   V  + +  +   +VS SRD T+++W+++TG C+    GH   VR V+ 
Sbjct: 183 ECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRP 242

Query: 509 -YDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF------------------ 549
             DG  + S + D  V+VW   T+ C   L+ H + V  + +                  
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302

Query: 550 ----DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTV 603
                G  ++SGS D +I++WDV TG C+ TL GH +   G+        ++S   D T+
Sbjct: 303 KSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTL 362

Query: 604 KIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLK 652
           ++WD K  +C++TL   N H+  VT L F+K   +V+T S D TVK+W+ +
Sbjct: 363 RVWDYKNKRCMKTL---NAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score =  137 bits (344), Expect = 4e-32
 Identities = 84/267 (31%), Positives = 130/267 (48%), Gaps = 31/267 (11%)

Query: 374 KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN 432
           + LKGH D V        G  + S S D T+K+W     +C+RT+ GH   V S  +  N
Sbjct: 144 RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPN 203

Query: 433 --IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDI 488
              I+S S D+T+K+W  +TG C+ T  GH   VR +  ++    + S S D T+RVW +
Sbjct: 204 GDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVV 263

Query: 489 ETGQCLHVLMGHVAAVRCVQY----------------------DGRRVVSGAYDFMVKVW 526
            T +C   L  H   V C+ +                       G  ++SG+ D  +K+W
Sbjct: 264 ATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323

Query: 527 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 584
           D  T  CL TL GH N V  + F   G  ++S + D ++RVWD +   C+ TL  H+   
Sbjct: 324 DVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFV 383

Query: 585 SGMELKDN--ILVSGNADSTVKIWDIK 609
           + ++       +V+G+ D TVK+W+ +
Sbjct: 384 TSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score =  134 bits (336), Expect = 4e-31
 Identities = 83/260 (31%), Positives = 136/260 (52%), Gaps = 35/260 (13%)

Query: 432 NIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 489
           ++++S S D T+KVW+ ETG+   TL GHT +V+ +      K + S S D T+++WD +
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQ 180

Query: 490 TGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN--RV 544
             +C+  + GH   V++V  +  +G  +VS + D  +K+W+ +T  C+ T  GH    R+
Sbjct: 181 GFECIRTMHGHDHNVSSV-AIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRM 239

Query: 545 YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-----------------SLTSGM 587
                DG  + S S D ++RVW V T  C   L  H+                 S  +G 
Sbjct: 240 VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGS 299

Query: 588 ELKDN-----ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITS 640
           E K +      L+SG+ D T+K+WD+ TG CL TL G   H + V  + F+    F+++ 
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---HDNWVRGVLFHSGGKFILSC 356

Query: 641 SDDGTVKLWDLKTGEFIRNL 660
           +DD T+++WD K    ++ L
Sbjct: 357 ADDKTLRVWDYKNKRCMKTL 376



 Score =  125 bits (315), Expect = 1e-28
 Identities = 73/237 (30%), Positives = 122/237 (51%), Gaps = 33/237 (13%)

Query: 455 HTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-- 510
           + L GH S V  +  H     +VS S DAT++VWD ETG     L GH  +V+ + +D  
Sbjct: 102 YALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHS 161

Query: 511 GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDV 568
           G+ + S + D  +K+WD +   C+ T+ GH + V S+    +G H+VS S D +I++W+V
Sbjct: 162 GKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEV 221

Query: 569 ETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 626
           +TG C+ T TGH+     +    +  ++ S + D TV++W + T +C   L+   +H+  
Sbjct: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELR---EHEHV 278

Query: 627 VTCLQFNKN----------------------FVITSSDDGTVKLWDLKTGEFIRNLV 661
           V C+ +                         F+++ S D T+K+WD+ TG  +  LV
Sbjct: 279 VECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV 335


>gi|157266266 WD repeat domain 86 [Homo sapiens]
          Length = 376

 Score =  162 bits (411), Expect = 8e-40
 Identities = 91/286 (31%), Positives = 141/286 (49%), Gaps = 21/286 (7%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAET 450
           G R+++GS+D T ++WS   G+C   L GH   V   Q+ D    + S D T++ W+  T
Sbjct: 27  GQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSADCTIRRWDVLT 86

Query: 451 GECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
           G+C+    GHTS V  + +   ++ S S D T RVW ++ GQ      GH   V  + Y 
Sbjct: 87  GQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYS 146

Query: 511 ----------------GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GI 552
                           G  +V+G+ D   KVW   +  C  TL+GHT  V  L  D  G 
Sbjct: 147 APWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGH 206

Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQ 612
              +GS D +IR WD+ +G  +     H+     +EL + ++ SG+AD TVK W   TG+
Sbjct: 207 TAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGE 266

Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
           C++T      H+  V+ L+++   + T S D   + +D ++GE  R
Sbjct: 267 CVRTF---TAHRRNVSALKYHAGTLFTGSGDACARAFDAQSGELRR 309



 Score =  151 bits (381), Expect = 2e-36
 Identities = 85/306 (27%), Positives = 146/306 (47%), Gaps = 22/306 (7%)

Query: 365 WRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424
           W   + +   +L+GH+ +V  C Q       + S D T++ W  +TG+CL+   GHT  V
Sbjct: 42  WSTADGQCCALLQGHESYVTFC-QLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIV 100

Query: 425 WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK------------ 472
               + +N + S S DRT +VW+ + G+      GH + V  +                 
Sbjct: 101 NRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEA 160

Query: 473 ----RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526
                +V+GS D T +VW + +G C   L GH  AV C+  D  G    +G+ D  ++ W
Sbjct: 161 AAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAW 220

Query: 527 DPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
           D  +   L   + H   V  L+     V SGS D +++ W  +TG C+ T T H+   S 
Sbjct: 221 DILSGEQLRVFREHRGSVICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSA 280

Query: 587 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTV 646
           ++     L +G+ D+  + +D ++G+  +  +G   H   + C+Q +   + T+S DG +
Sbjct: 281 LKYHAGTLFTGSGDACARAFDAQSGELRRVFRG---HTFIINCIQVHGQVLYTASHDGAL 337

Query: 647 KLWDLK 652
           +LWD++
Sbjct: 338 RLWDVR 343



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 50/182 (27%), Positives = 84/182 (46%), Gaps = 21/182 (11%)

Query: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
           G  L V   H   +  +    DG+R+++G+ D   ++W      C   LQGH + V   Q
Sbjct: 5   GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQ 64

Query: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
            +     + S D +IR WDV TG C+    GH S+ + + + +N L S + D T ++W +
Sbjct: 65  LEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSV 124

Query: 609 KTGQCLQTLQGPNKHQSAVTCLQFNK----------------NFVITSSDDGTVKLWDLK 652
             GQ  +  +G   H++ V  L ++                   ++T S DGT K+W + 
Sbjct: 125 DKGQMSREFRG---HRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVA 181

Query: 653 TG 654
           +G
Sbjct: 182 SG 183


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  160 bits (405), Expect = 4e-39
 Identities = 96/299 (32%), Positives = 167/299 (55%), Gaps = 34/299 (11%)

Query: 376 LKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV----WSSQM 429
           L GH +  ++ ++F   G  + S S D  + +W A  GK  +TL GH   +    WSS  
Sbjct: 37  LVGHTE-AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSD- 94

Query: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487
             + ++S S D+TLK+W+  +G+C+ TL GH++ V C + +     ++SGS D T+++W+
Sbjct: 95  -SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153

Query: 488 IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
           ++TG+CL  L  H   V  V ++  G  +VSG+YD + ++WD  +  CL TL    N   
Sbjct: 154 VKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPV 213

Query: 546 S-LQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ----------SLTSGMELKDN 592
           S ++F  +G ++++ +LD ++++WD   G C+ T TGH+          S+T G      
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGG-----K 268

Query: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSS--DDGTVKLW 649
            +VSG+ D+ V IW+++T + +Q LQG      +  C    +N + +++  +D T+KLW
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC-HPTENLIASAALENDKTIKLW 326



 Score =  152 bits (384), Expect = 1e-36
 Identities = 90/265 (33%), Positives = 144/265 (54%), Gaps = 21/265 (7%)

Query: 412 KCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVR--CM 467
           KC  TLVGHT  V S +   N   + S S DR + +W A  G+   TLYGH   +     
Sbjct: 34  KC--TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91

Query: 468 HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKV 525
                R+VS S D TL++WD+ +G+CL  L GH   V C  ++     ++SG++D  VK+
Sbjct: 92  SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKI 151

Query: 526 WDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
           W+ +T  CL TL  H++ V ++ F+  G  +VSGS D   R+WD  +G C+ TL    + 
Sbjct: 152 WEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNP 211

Query: 584 -TSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFN-----KN 635
             S ++   N   +++   D+T+K+WD   G+CL+T  G   H++   C+  N       
Sbjct: 212 PVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG---HKNEKYCIFANFSVTGGK 268

Query: 636 FVITSSDDGTVKLWDLKTGEFIRNL 660
           ++++ S+D  V +W+L+T E ++ L
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKL 293



 Score =  147 bits (372), Expect = 3e-35
 Identities = 87/259 (33%), Positives = 136/259 (52%), Gaps = 17/259 (6%)

Query: 365 WRRGELKSPKVLKGHDDHVI-TCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG 423
           W   + K  K L GH+  +         +R+VS SDD TLK+W   +GKCL+TL GH+  
Sbjct: 68  WGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY 127

Query: 424 VWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSR 479
           V+        N+IISGS D T+K+W  +TG+C+ TL  H+  V  +H +     +VSGS 
Sbjct: 128 VFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSY 187

Query: 480 DATLRVWDIETGQCLHVLM-GHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHT 536
           D   R+WD  +GQCL  L+      V  V++  +G+ +++   D  +K+WD     CL T
Sbjct: 188 DGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKT 247

Query: 537 LQGHTNRVYSLQFD-----GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMEL 589
             GH N  Y +  +     G  +VSGS D  + +W+++T   +  L GH    +++    
Sbjct: 248 YTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307

Query: 590 KDNILVSG--NADSTVKIW 606
            +N++ S     D T+K+W
Sbjct: 308 TENLIASAALENDKTIKLW 326



 Score =  124 bits (312), Expect = 2e-28
 Identities = 71/241 (29%), Positives = 124/241 (51%), Gaps = 8/241 (3%)

Query: 426 SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATL 483
           S   +  + +S S +++ +V          TL GHT  V  +    + + + S S D  +
Sbjct: 6   SRDAKAQLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLI 65

Query: 484 RVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHT 541
            +W    G+    L GH   +  V +  D  R+VS + D  +K+WD  +  CL TL+GH+
Sbjct: 66  IIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHS 125

Query: 542 NRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSG 597
           N V+   F+     ++SGS D ++++W+V+TG C+ TL+ H    S +      +++VSG
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG 185

Query: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFI 657
           + D   +IWD  +GQCL+TL   +    +      N  +++T++ D T+KLWD   G  +
Sbjct: 186 SYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCL 245

Query: 658 R 658
           +
Sbjct: 246 K 246



 Score =  105 bits (261), Expect = 2e-22
 Identities = 56/173 (32%), Positives = 96/173 (55%), Gaps = 11/173 (6%)

Query: 497 LMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGI 552
           L+GH  AV  V++  +G  + S + D ++ +W         TL GH   +  + +  D  
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96

Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT--SGMELKDNILVSGNADSTVKIWDIKT 610
            +VS S D ++++WDV +G C+ TL GH +           N+++SG+ D TVKIW++KT
Sbjct: 97  RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156

Query: 611 GQCLQTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKLWDLKTGEFIRNLV 661
           G+CL+TL     H   V+ + FN   + +++ S DG  ++WD  +G+ ++ LV
Sbjct: 157 GKCLKTLSA---HSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206


>gi|45594312 TNF receptor-associated factor 7 [Homo sapiens]
          Length = 670

 Score =  134 bits (338), Expect = 2e-31
 Identities = 90/281 (32%), Positives = 143/281 (50%), Gaps = 15/281 (5%)

Query: 378 GHDDHV-ITCLQFCGNRIVSGSDDNTLKVW-SAVTGKCLRTLVGHTGGVWSSQMRDNIII 435
           GH   V   C+   G+ + SGS D T+KVW +  T KC +TL GH G V +  ++   + 
Sbjct: 394 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLY 453

Query: 436 SGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLH 495
           SGS D T+ VW+ +  + ++T+  H + V  +      + SGS  A ++VWDI  G  L 
Sbjct: 454 SGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI-VGTELK 511

Query: 496 V---LMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGI 552
           +   L G    VR +      + SG+Y   +K+WD  T  C+H LQ     VYS+     
Sbjct: 512 LKKELTGLNHWVRALVAAQSYLYSGSYQ-TIKIWDIRTLDCIHVLQTSGGSVYSIAVTNH 570

Query: 553 HVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL----KDNILVSGNADSTVKIWDI 608
           H+V G+ +  I VWD+E+   + TLTGH      + +        + S + D ++++W +
Sbjct: 571 HIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSM 630

Query: 609 KTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 649
               C QTL    +HQ +VT L  ++  + + + D TVK+W
Sbjct: 631 DNMICTQTLL---RHQGSVTALAVSRGRLFSGAVDSTVKVW 668



 Score = 89.7 bits (221), Expect = 8e-18
 Identities = 68/217 (31%), Positives = 103/217 (47%), Gaps = 21/217 (9%)

Query: 492 QCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQ 548
           +C    +GH   V   CV   G  + SG+ D  +KVWD   T  C  TL+GH   V +L 
Sbjct: 387 KCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALC 446

Query: 549 FDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
             G  + SGS D +I VWD++    ++T+  H +    +    N+L SG+  + +K+WDI
Sbjct: 447 IQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKA-IKVWDI 505

Query: 609 KTGQCL--QTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESG 666
              +    + L G N    A+   Q      + S    T+K+WD++T + I  L T    
Sbjct: 506 VGTELKLKKELTGLNHWVRALVAAQS----YLYSGSYQTIKIWDIRTLDCIHVLQT---- 557

Query: 667 GSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFD 703
            SGG V+ I  +N  +VC      GT E  + V D +
Sbjct: 558 -SGGSVYSIAVTNHHIVC------GTYENLIHVWDIE 587


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  130 bits (328), Expect = 3e-30
 Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)

Query: 377 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 432
           KGH D  +TC+ F  N  ++ SGS D+ L VW            GH   V       +  
Sbjct: 16  KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 490
           ++ SGS D+T+++W             HT+TVR +H     +  V+ S D T++VW    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
            + L  L  H+  VRC ++  DGR +VS + D  VK+WD  +  C+H+   H   V  + 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 549 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 604
           F   G  + +  +D +++VWDV T   +     H +  +G+      N L++ ++DST+K
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254

Query: 605 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649
           I D+  G+ L TL G   HQ   T + F++   +  +   D  V +W
Sbjct: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)

Query: 459 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 514
           GH   V C+   ++ K++ SGS D+ L VW ++     +   GH  AV CV +   G  +
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 572
            SG+ D  V++W P  +      + HT  V S+ F  DG   V+ S D +++VW      
Sbjct: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136

Query: 573 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
            + +L+ H +     +   +  ++VS + D TVK+WD  + +C+ +     +H   VT +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193

Query: 631 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
            F+ +   +  +  D TVK+WD++T   +++
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 19/250 (7%)

Query: 384 ITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGST 439
           +  + FC  G   V+ SDD T+KVW+    K L +L  H   V  ++   +  +I+S S 
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD 165

Query: 440 DRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVL 497
           D+T+K+W+  + EC+H+   H   V  +  H     + +   D T++VWD+ T + L   
Sbjct: 166 DKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY 225

Query: 498 MGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIH 553
             H AAV  + +   G  +++ + D  +K+ D      L+TL GH     ++ F   G +
Sbjct: 226 QLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEY 285

Query: 554 VVSGSLDTSIRVWD-----VETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDI 608
             SG  D  + VW      V+ G          +L S M    N+ VS   +  + + + 
Sbjct: 286 FASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSM---GNLTVS-ILEQRLTLTED 341

Query: 609 KTGQCLQTLQ 618
           K  QCL+  Q
Sbjct: 342 KLKQCLENQQ 351


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  130 bits (328), Expect = 3e-30
 Identities = 86/287 (29%), Positives = 138/287 (48%), Gaps = 18/287 (6%)

Query: 377 KGHDDHVITCLQFCGN--RIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN-- 432
           KGH D  +TC+ F  N  ++ SGS D+ L VW            GH   V       +  
Sbjct: 16  KGHRD-AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 433 IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIET 490
           ++ SGS D+T+++W             HT+TVR +H     +  V+ S D T++VW    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 491 GQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
            + L  L  H+  VRC ++  DGR +VS + D  VK+WD  +  C+H+   H   V  + 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 549 F--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVK 604
           F   G  + +  +D +++VWDV T   +     H +  +G+      N L++ ++DST+K
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254

Query: 605 IWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649
           I D+  G+ L TL G   HQ   T + F++   +  +   D  V +W
Sbjct: 255 ILDLMEGRLLYTLHG---HQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 59/211 (27%), Positives = 106/211 (50%), Gaps = 13/211 (6%)

Query: 459 GHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRV 514
           GH   V C+   ++ K++ SGS D+ L VW ++     +   GH  AV CV +   G  +
Sbjct: 17  GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76

Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGN 572
            SG+ D  V++W P  +      + HT  V S+ F  DG   V+ S D +++VW      
Sbjct: 77  ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136

Query: 573 CIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
            + +L+ H +     +   +  ++VS + D TVK+WD  + +C+ +     +H   VT +
Sbjct: 137 FLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYV 193

Query: 631 QFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
            F+ +   +  +  D TVK+WD++T   +++
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 224


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score =  125 bits (314), Expect = 1e-28
 Identities = 89/294 (30%), Positives = 147/294 (50%), Gaps = 20/294 (6%)

Query: 374 KVLKGHDDHVITCLQFCGNR-IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSS--QMR 430
           +V+ GH   V       GN+  V+GS D T+K+W   +GK   +L GH   V       R
Sbjct: 198 RVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTR 257

Query: 431 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDI 488
              + S   D+ +K W+ E  + I   +GH S V  + LH     +V+ SRD+T R+WD+
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317

Query: 489 ETGQCLHVLMGH---VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
            T   +H L GH   VA VRC Q    ++++G++D  +++WD        TL  H   V 
Sbjct: 318 RTKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVR 376

Query: 546 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL-KDNILVSGNADST 602
           ++     H    SGS D +I+ W    G+ I  L+GH ++ + + +  D +LVSG  + T
Sbjct: 377 AVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGT 435

Query: 603 VKIWDIKTGQCLQTLQ-----GPNKHQSAVTCLQF--NKNFVITSSDDGTVKLW 649
           + +WD +TG   Q +      G    +S +    F  +++ ++T+  D T+K++
Sbjct: 436 MHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489



 Score =  123 bits (309), Expect = 5e-28
 Identities = 79/254 (31%), Positives = 133/254 (52%), Gaps = 15/254 (5%)

Query: 412 KCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL 469
           K  R + GH G V    +   +   ++GS DRT+K+W+  +G+   +L GH STVR + +
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254

Query: 470 HEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--VVSGAYDFMVKV 525
             +   + S   D  ++ WD+E  + +    GH++AV  +        +V+ + D   ++
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314

Query: 526 WDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSL 583
           WD  T+  +HTL GHTN V +++       +++GS DT+IR+WD+  G    TLT H+  
Sbjct: 315 WDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKS 374

Query: 584 TSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS- 640
              + L  +     SG+ D+ +K W    G  +Q L G   H + +  L  N + V+ S 
Sbjct: 375 VRAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSG---HNAIINTLTVNSDGVLVSG 430

Query: 641 SDDGTVKLWDLKTG 654
           +D+GT+ LWD +TG
Sbjct: 431 ADNGTMHLWDWRTG 444



 Score =  108 bits (269), Expect = 2e-23
 Identities = 71/242 (29%), Positives = 118/242 (48%), Gaps = 16/242 (6%)

Query: 459 GHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRR--V 514
           GH   VRC+ +    +  V+GS D T+++WD+ +G+    L GH++ VR V    R   +
Sbjct: 202 GHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYL 261

Query: 515 VSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN 572
            S   D  VK WD E    +    GH + VY L        +V+ S D++ R+WDV T  
Sbjct: 262 FSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKA 321

Query: 573 CIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCL 630
            +HTL+GH +  + +  +  +  +++G+ D+T+++WD+  G+   TL    K   AV   
Sbjct: 322 SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVL- 380

Query: 631 QFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRN 690
              +++   S     +K W    G FI+NL      G   ++  +   N+  V   G+ N
Sbjct: 381 -HPRHYTFASGSPDNIKQWKFPDGSFIQNL-----SGHNAIINTLTV-NSDGVLVSGADN 433

Query: 691 GT 692
           GT
Sbjct: 434 GT 435



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 53/166 (31%), Positives = 85/166 (51%), Gaps = 7/166 (4%)

Query: 496 VLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--G 551
           V+ GH+  VRC+  +   +  V+G+ D  +K+WD  +     +L GH + V  +      
Sbjct: 199 VISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRS 258

Query: 552 IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNI--LVSGNADSTVKIWDIK 609
            ++ S   D  ++ WD+E    I    GH S   G++L   I  LV+ + DST +IWD++
Sbjct: 259 PYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVR 318

Query: 610 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGE 655
           T   + TL G     + V C Q  +  +IT S D T++LWDL  G+
Sbjct: 319 TKASVHTLSGHTNAVATVRC-QAAEPQIITGSHDTTIRLWDLVAGK 363


>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
          Length = 1051

 Score =  125 bits (314), Expect = 1e-28
 Identities = 95/410 (23%), Positives = 178/410 (43%), Gaps = 52/410 (12%)

Query: 278 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 324
           RDFI  LP  L+ Y+L  L+   L + A   ++W  +A+             + + + + 
Sbjct: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334

Query: 325 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGELKSPKV 375
               GID P +  +  +  P  +         H  WK     ++ + T ++  E +   +
Sbjct: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLI 393

Query: 376 LKGHDDHVITC-----------------LQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-L 417
               ++  + C                 + + G  +++ S +  + +   +  K +    
Sbjct: 394 ----EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEF 449

Query: 418 VGHTGGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVV 475
            GH G V +  +   +N ++SGS D +++ W+ ++G C     GH  T+ CM L + R+V
Sbjct: 450 RGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLV 509

Query: 476 SGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLH 535
           SG RD  ++VWD++TG+CL     H   +   + +   +VS     +VKVW       + 
Sbjct: 510 SGGRDCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVK 568

Query: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNI 593
           TL GH   V  L FD  H++SGS D  +  W +  +   C+     H      + L    
Sbjct: 569 TLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLR 627

Query: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVT-CLQFNKNFVITSSD 642
           ++S  AD  ++I++   G C++ L+   +    ++  +Q N+  V T S+
Sbjct: 628 VISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESN 677



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)

Query: 505 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
           R + Y G  +++ + +  + + D  + +      +GH   V +L    +   ++SGS D 
Sbjct: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475

Query: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
           SIR WD+++G C     GHQ   + M+L  N LVSG  D  VK+WD+ TG+CL+T     
Sbjct: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531

Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 675
           +H+  +   + N  ++++S + G VK+W +   + ++ L    SG  G V       W +
Sbjct: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587

Query: 676 RASNTKLVCAVGSRNGTEETKLL 698
            + +T  +    S  G  E  L+
Sbjct: 588 LSGSTDGLVMAWSMVGKYERCLM 610



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)

Query: 507 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 564
           V  + R V  G Y+  +    WD              NRV  + + G  +++ S +  I 
Sbjct: 391 VLIEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435

Query: 565 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
           + D+     I     GH      + L  ++N L+SG+ D +++ WD+K+G C +   G  
Sbjct: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493

Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
            HQ  +TC+   KN +++   D  VK+WD+ TG+ ++
Sbjct: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score =  122 bits (307), Expect = 9e-28
 Identities = 85/293 (29%), Positives = 137/293 (46%), Gaps = 26/293 (8%)

Query: 380 DDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVW----------SS 427
           DD  I+   F  N   + +       K+WS      L TL GH   V           S 
Sbjct: 230 DDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSL 289

Query: 428 QMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR--DATLRV 485
             +D  + S + D ++K+W+ ++ E +  + GHT  V  +  H      G+   D + R+
Sbjct: 290 DPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRL 349

Query: 486 WDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNR 543
           WD+E  + +    GH   V  + +  DG    +G  D   +VWD  T  C+  L+GH   
Sbjct: 350 WDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKE 409

Query: 544 VYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGME---LKDNILVSGN 598
           +Y + F  +G H+ +GS D + +VWD+    C++T+  HQ+L +G++   +  N L++G 
Sbjct: 410 IYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGA 469

Query: 599 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLW 649
            D+T KIW       L+TL G   H+  V  L  + +   + T S D T KLW
Sbjct: 470 YDNTAKIWTHPGWSPLKTLAG---HEGKVMGLDISSDGQLIATCSYDRTFKLW 519



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 48/179 (26%), Positives = 86/179 (48%), Gaps = 9/179 (5%)

Query: 400 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGS--TDRTLKVWNAETGECIHTL 457
           D + ++W     + +    GH+ GV+      +  ++G+   D   +VW+  TG CI  L
Sbjct: 344 DRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFL 403

Query: 458 YGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD---GR 512
            GH   +  ++       + +GS D T +VWD+   +C++ +  H   V  V+++   G 
Sbjct: 404 EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGN 463

Query: 513 RVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVE 569
            +++GAYD   K+W     + L TL GH  +V  L    DG  + + S D + ++W  E
Sbjct: 464 FLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 59/231 (25%), Positives = 98/231 (42%), Gaps = 45/231 (19%)

Query: 444 KVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA 503
           K+W+      +HTL GH + V  +  H K  VS      L   D+    C          
Sbjct: 256 KLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVS------LDPKDVNLASC---------- 299

Query: 504 VRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
                         A D  VK+W  +++  +  ++GHT RV  + +   G  + +   D 
Sbjct: 300 --------------AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDR 345

Query: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 619
           S R+WD+E    I    GH      +    +  +  +G  D+  ++WD++TG+C+  L+G
Sbjct: 346 SWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEG 405

Query: 620 PNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFI------RNLVT 662
              H   +  + F+ N   + T S D T K+WDL+    +      +NLVT
Sbjct: 406 ---HLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 5/104 (4%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG---GVWSSQMRDNIIISGSTDRTLKVWN 447
           G  I +GS DNT KVW     +C+ T+  H     GV    +  N +++G+ D T K+W 
Sbjct: 419 GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT 478

Query: 448 AETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIE 489
                 + TL GH   V  + +    + + + S D T ++W  E
Sbjct: 479 HPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522


>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
          Length = 752

 Score =  122 bits (306), Expect = 1e-27
 Identities = 90/381 (23%), Positives = 170/381 (44%), Gaps = 43/381 (11%)

Query: 278 RDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAE-------------DNLLWREK 324
           RDFI  LP  L+ Y+L  L+   L + A   ++W  +A+             + + + + 
Sbjct: 275 RDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQG 334

Query: 325 CKEEGIDEPLHIKRRKVIKPGFI---------HSPWKSAYIRQHRIDTNWRRGE-----L 370
               GID P +  +  +  P  +         H  WK     ++ + T ++  E     +
Sbjct: 335 SYTRGID-PNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLM 393

Query: 371 KSPKVLKG-HDDHVIT-------CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRT-LVGHT 421
           +   V  G ++  +++        + + G  +++ S +  + +   +  K +     GH 
Sbjct: 394 EERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHA 453

Query: 422 GGVWSSQM--RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR 479
           G V +  +   +N ++SGS D +++ W+ ++G C     GH  T+ CM L + R+VSG R
Sbjct: 454 GSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGR 513

Query: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQG 539
           D  ++VWD++TG+CL     H   +   + +   +VS     +VKVW       + TL G
Sbjct: 514 DCQVKVWDVDTGKCLKTFR-HKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSG 572

Query: 540 HTNRVYSLQFDGIHVVSGSLDTSIRVWDV--ETGNCIHTLTGHQSLTSGMELKDNILVSG 597
           H   V  L FD  H++SGS D  +  W +  +   C+     H      + L    ++S 
Sbjct: 573 HEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFK-HPKEVLDVSLLFLRVISA 631

Query: 598 NADSTVKIWDIKTGQCLQTLQ 618
            AD  ++I++   G C++ ++
Sbjct: 632 CADGKIRIYNFFNGNCMKVIK 652



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 17/203 (8%)

Query: 505 RCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDT 561
           R + Y G  +++ + +  + + D  + +      +GH   V +L    +   ++SGS D 
Sbjct: 416 RVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDL 475

Query: 562 SIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
           SIR WD+++G C     GHQ   + M+L  N LVSG  D  VK+WD+ TG+CL+T     
Sbjct: 476 SIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF---- 531

Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGV------VWRI 675
           +H+  +   + N  ++++S + G VK+W +   + ++ L    SG  G V       W +
Sbjct: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTL----SGHEGAVKCLFFDQWHL 587

Query: 676 RASNTKLVCAVGSRNGTEETKLL 698
            + +T  +    S  G  E  L+
Sbjct: 588 LSGSTDGLVMAWSMVGKYERCLM 610



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 55/184 (29%), Positives = 91/184 (49%), Gaps = 8/184 (4%)

Query: 362 DTNWRRGELKS---PKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLV 418
           D + R  +LKS    ++  GH    ITC+  C NR+VSG  D  +KVW   TGKCL+T  
Sbjct: 474 DLSIRYWDLKSGVCTRIFGGHQG-TITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTF- 531

Query: 419 GHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGS 478
            H   + ++++ D  I+S      +KVW+    + + TL GH   V+C+   +  ++SGS
Sbjct: 532 RHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGS 591

Query: 479 RDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHT 536
            D  +  W +  G+    LM   H   V  V     RV+S   D  +++++     C+  
Sbjct: 592 TDGLVMAWSM-VGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFFNGNCMKV 650

Query: 537 LQGH 540
           ++ +
Sbjct: 651 IKAN 654



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 23/157 (14%)

Query: 507 VQYDGRRVVSGAYDFMV--KVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIR 564
           V  + R V  G Y+  +    WD              NRV  + + G  +++ S +  I 
Sbjct: 391 VLMEERNVFCGTYNVRILSDTWDQ-------------NRV--IHYSGGDLIAVSSNRKIH 435

Query: 565 VWDVETGNCIHT-LTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPN 621
           + D+     I     GH      + L  ++N L+SG+ D +++ WD+K+G C +   G  
Sbjct: 436 LLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGG-- 493

Query: 622 KHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIR 658
            HQ  +TC+   KN +++   D  VK+WD+ TG+ ++
Sbjct: 494 -HQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLK 529


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  121 bits (304), Expect = 2e-27
 Identities = 66/217 (30%), Positives = 117/217 (53%), Gaps = 11/217 (5%)

Query: 414 LRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470
           L+ +V H   V S    +    ++ +G  D  + +W+     CI +L GHTS V  + L+
Sbjct: 13  LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72

Query: 471 --EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526
             E+ +V+GS+  ++RVWD+E  + L  LMGH A +  + +   G  V SG+ D  +K+W
Sbjct: 73  TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132

Query: 527 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 584
           D   + C+   +GH+  V  L+F  DG  + S + D ++++WD+  G  +    GH    
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192

Query: 585 SGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 619
           + +E   N  +L SG++D T++ WD++  Q +  ++G
Sbjct: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG 229



 Score =  116 bits (291), Expect = 6e-26
 Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNA 448
           G  + +G DD  + +WS     C+ +L GHT  V S ++   + +I++GS   +++VW+ 
Sbjct: 33  GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92

Query: 449 ETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 506
           E  + + TL GH + +  +  H   + V SGS+D  +++WDI    C+    GH  AVRC
Sbjct: 93  EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152

Query: 507 VQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTS 562
           +++  DG+ + S A D  VK+WD      +    GHT  V  ++F  +   + SGS D +
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212

Query: 563 IRVWDVETGNCIHTLTG 579
           IR WD+E    +  + G
Sbjct: 213 IRFWDLEKFQVVSCIEG 229



 Score =  102 bits (254), Expect = 1e-21
 Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 14/210 (6%)

Query: 454 IHTLYGHTSTVRCMHLHE---KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
           +  +  H S V  + L +   + + +G  D  + +W I    C+  L GH + V  V+ +
Sbjct: 13  LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72

Query: 511 GRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVW 566
                +V+G+    ++VWD E    L TL GH   + SL F   G  V SGS DT+I++W
Sbjct: 73  TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132

Query: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
           D+    C+    GH      +    +   L S   D TVK+WD+  G+ +    G   H 
Sbjct: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG---HT 189

Query: 625 SAVTCLQFNKN--FVITSSDDGTVKLWDLK 652
             V  ++F+ N   + + S D T++ WDL+
Sbjct: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 17/213 (7%)

Query: 489 ETGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
           +T   L  ++ H + V  +   +  GR + +G  D  V +W      C+ +L GHT+ V 
Sbjct: 8   KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67

Query: 546 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADS 601
           S++ +     +V+GS   SIRVWD+E    + TL GH++    ++       + SG+ D+
Sbjct: 68  SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127

Query: 602 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
            +K+WDI+   C+   +G   H  AV CL+F+ +  ++ +++DD TVKLWDL  G+ +  
Sbjct: 128 NIKLWDIRRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS- 183

Query: 660 LVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692
               E  G  G V  +     + + A GS + T
Sbjct: 184 ----EFPGHTGPVNVVEFHPNEYLLASGSSDRT 212



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 9/188 (4%)

Query: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NIIISGSTDRTLKVWNAETG 451
           IV+GS   +++VW     K LRTL+GH   + S         + SGS D  +K+W+    
Sbjct: 78  IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137

Query: 452 ECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 509
            C+    GH+  VRC+      K + S + D T+++WD+  G+ +    GH   V  V++
Sbjct: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197

Query: 510 DGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRV 565
                 + SG+ D  ++ WD E    +  ++G    V S+ F  DG  + SG  D S+RV
Sbjct: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256

Query: 566 WDVETGNC 573
           +  E   C
Sbjct: 257 YGWEPERC 264



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 10/174 (5%)

Query: 365 WRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 422
           W     K  + L GH  ++ + L F   G  + SGS D  +K+W      C+    GH+ 
Sbjct: 90  WDLEAAKILRTLMGHKANICS-LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148

Query: 423 GVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGS 478
            V   +   +   + S + D T+K+W+   G+ +    GHT  V  +  H  E  + SGS
Sbjct: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208

Query: 479 RDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFM-VKVWDPE 529
            D T+R WD+E  Q +  + G    VR V +  DG  + SG  D + V  W+PE
Sbjct: 209 SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262


>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
           sapiens]
          Length = 472

 Score =  120 bits (301), Expect = 4e-27
 Identities = 89/300 (29%), Positives = 149/300 (49%), Gaps = 23/300 (7%)

Query: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGG--VWSSQM 429
           K+L GH+  V TC  FC    +++SGS D T+K+W  V G  +R          V  S  
Sbjct: 96  KILSGHEHAVSTC-HFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSIT 154

Query: 430 RDNI-IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE-KRVVSG-SRDATLRVW 486
            D+  +I+ S D+T++ W+ ETG+ +  +   T  V C    + K VVSG   D  + + 
Sbjct: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214

Query: 487 DIETGQCLHVLMGHVA---AVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTL-QGHTN 542
           D E    + V+  H        C   D +RV S + D  +K+WD  ++  L T+ + H+N
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274

Query: 543 RVYS--LQFDGIHVVSGSLDTSIRVWDVETGN------CIHTLTGHQSLTSGMELK--DN 592
            + +    F G  + + S D ++++W+V TG       C+  + GH+   S        +
Sbjct: 275 AISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSS 334

Query: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
            L+SG  D TV IWD+  G    +L+G N     V  +  NK +++++S D T++LW+++
Sbjct: 335 FLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDV-AISNNKKWILSASKDRTMRLWNIE 393



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 78/261 (29%), Positives = 125/261 (47%), Gaps = 24/261 (9%)

Query: 415 RTLVGHTGGVWSSQ--MRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST--VRCMHLH 470
           + L GH   V +    + D  ++SGS D T+K+W+   G  +           V C    
Sbjct: 96  KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITG 155

Query: 471 EK-RVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC-VQYDGRRVVSGA-YDFMVKVWD 527
           +  RV++ S D T+R WD+ETG+ L  +      V C    DG+ VVSG   D  + + D
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIMD 215

Query: 528 PETETCLHTLQGH-TNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLT-GHQSL 583
            E  T +  ++ H T  + S  FD     V S SLD  I++WDV +   + T+T  H + 
Sbjct: 216 AENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNA 275

Query: 584 TSG--MELKDNILVSGNADSTVKIWDIKTGQ------CLQTLQGPNKHQSAVTCLQF--N 633
            S        + L + + D  +KIW++ TG+      C+  +QG   H+ +V+   F  +
Sbjct: 276 ISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQG---HEGSVSSCHFARD 332

Query: 634 KNFVITSSDDGTVKLWDLKTG 654
            +F+I+   D TV +WD+  G
Sbjct: 333 SSFLISGGFDRTVAIWDVAEG 353



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 16/229 (6%)

Query: 457 LYGHTSTVRCMH--LHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAA--VRC-VQYDG 511
           L GH   V   H  + + +++SGS D T+++WD   G  +        A  V C +  D 
Sbjct: 98  LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDS 157

Query: 512 RRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-SLDTSIRVWDV 568
            RV++ +YD  V+ WD ET   L  ++  T  + S +F  DG +VVSG  +D  I + D 
Sbjct: 158 SRVIAASYDKTVRAWDLETGKLLWKVRYDTF-IVSCKFSPDGKYVVSGFDVDHGICIMDA 216

Query: 569 ETGNCIHTLTGH--QSLTSGMELKDNILVSG-NADSTVKIWDIKTGQCLQTLQGPNKHQS 625
           E    +  +  H  +S+TS     D+  V+  + D  +KIWD+ +   L T+   + +  
Sbjct: 217 ENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAI 276

Query: 626 AVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRN---LVTLESGGSGGV 671
           +  C  F+ +F+ TSS D  +K+W++ TGEF RN    VTL  G  G V
Sbjct: 277 SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEF-RNCGACVTLMQGHEGSV 324


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  118 bits (295), Expect = 2e-26
 Identities = 75/227 (33%), Positives = 116/227 (51%), Gaps = 19/227 (8%)

Query: 374 KVLKGHDDHVITCLQFCGNR--IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR- 430
           K+L GH   V     F  +R  ++S S+D T+++WS  T  CL    GH   VW +Q   
Sbjct: 537 KILYGHSGPVYGA-SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSP 595

Query: 431 -DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWD 487
                +SG  DR  ++W  +  + +    GH + V C   H     V +GS D T+R+WD
Sbjct: 596 YGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655

Query: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
           +  G C+ +  GH   +  + +  +GR + +GA D  V +WD      +  L+GHT+ V 
Sbjct: 656 VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVC 715

Query: 546 SLQF--DGIHVVSGSLDTSIRVW-------DVETGNCIHTLTGHQSL 583
           SL+F  DG  + SGS+D ++R+W       D+ET +   T TGH +L
Sbjct: 716 SLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDD-FTTATGHINL 761



 Score =  117 bits (293), Expect = 4e-26
 Identities = 84/268 (31%), Positives = 130/268 (48%), Gaps = 24/268 (8%)

Query: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTL-KVWNAETGE 452
           I  G  D+T++VWS VT K LR++          Q  D  +I   +D  L ++ + +T  
Sbjct: 485 IAGGFADSTVRVWS-VTPKKLRSV---------KQASDLSLIDKESDDVLERIMDEKTAS 534

Query: 453 CIHTLYGHTSTVRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
            +  LYGH+  V        R  ++S S D T+R+W ++T  CL    GH   V   Q+ 
Sbjct: 535 ELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFS 594

Query: 511 --GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVW 566
             G   VSG +D + ++W  +    L    GH   V   +F  +  +V +GS D ++R+W
Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654

Query: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
           DV  GNC+   TGH+     +    N   L +G  D  V +WDI  G  +  L+G   H 
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG---HT 711

Query: 625 SAVTCLQFNKN--FVITSSDDGTVKLWD 650
             V  L+F+++   + + S D TV+LWD
Sbjct: 712 DTVCSLRFSRDGEILASGSMDNTVRLWD 739



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 80/290 (27%), Positives = 132/290 (45%), Gaps = 27/290 (9%)

Query: 413 CLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470
           C  T +    G+ +  + D+  +I  G  D T++VW+  T + + ++   +     + L 
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASD----LSLI 516

Query: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528
           +K     S D   R+ D +T   L +L GH   V    +  D   ++S + D  V++W  
Sbjct: 517 DKE----SDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL 572

Query: 529 ETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
           +T TCL   +GH   V+  QF   G + VSG  D   R+W  +    +    GH +  + 
Sbjct: 573 QTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNC 632

Query: 587 MEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSD 642
                  N + +G+AD TV++WD+  G C++   G   H+  +  L F+ N  F+ T + 
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTG---HKGPIHSLTFSPNGRFLATGAT 689

Query: 643 DGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692
           DG V LWD+  G     L+  E  G    V  +R S    + A GS + T
Sbjct: 690 DGRVLLWDIGHG-----LMVGELKGHTDTVCSLRFSRDGEILASGSMDNT 734



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 98/467 (20%), Positives = 178/467 (38%), Gaps = 56/467 (11%)

Query: 33  MNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSS 92
           + R ++E+Q  Q+    +EH     ++    PR   Q D+  G L     R  +  +   
Sbjct: 317 LKRHLQEKQNNQIWNIVQEHLYI--DIFDGMPRSKQQIDAMVGSLAGEAKREANKSKVFF 374

Query: 93  GNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDL 152
           G  +E E  E    ++DEE E EE   ++      S  S  + +  +             
Sbjct: 375 GLLKEPEI-EVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAP----------- 422

Query: 153 PVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPC-KVSEYTSTTGLVPCSATPTTFGD 211
           P +++  P    + K+ + ++     +   LG      +  YT        +A   T   
Sbjct: 423 PQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDS 482

Query: 212 LRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQV 271
              A G      R+ SV P        K  +S      L  +D+  D         + ++
Sbjct: 483 SLIAGGFADSTVRVWSVTP--------KKLRSVKQASDLSLIDKESDDV-------LERI 527

Query: 272 IEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQ---TCRYWRILAEDNLLWREKCKEE 328
           ++ +   +   L      +Y  SF   ++ L ++    T R W +     L+  +     
Sbjct: 528 MDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK----- 582

Query: 329 GIDEPLHIKRRKVIKPGFIHSPWKSAYIR--QHRIDTNWRRGELKSPKVLKGHDDHVITC 386
           G + P+   +          SP+   ++     R+   W     +  ++  GH   V  C
Sbjct: 583 GHNYPVWDTQ---------FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADV-NC 632

Query: 387 LQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRT 442
            +F    N + +GS D T+++W  + G C+R   GH G + S     N   + +G+TD  
Sbjct: 633 TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGR 692

Query: 443 LKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487
           + +W+   G  +  L GHT TV  +      + + SGS D T+R+WD
Sbjct: 693 VLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  116 bits (291), Expect = 6e-26
 Identities = 75/262 (28%), Positives = 123/262 (46%), Gaps = 15/262 (5%)

Query: 400 DNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTL 457
           D+ L VW            GH   V       +  ++ SGS D+T+++W           
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 458 YGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRR 513
             HT+TVR +H     +  V+ S D T++VW     + L  L  H+  VRC ++  DGR 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 514 VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETG 571
           +VS + D  VK+WD  +  C+H+   H   V  + F   G  + +  +D +++VWDV T 
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181

Query: 572 NCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
             +     H +  +G+      N L++ ++DST+KI D+  G+ L TL G   HQ   T 
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG---HQGPATT 238

Query: 630 LQFNK--NFVITSSDDGTVKLW 649
           + F++   +  +   D  V +W
Sbjct: 239 VAFSRTGEYFASGGSDEQVMVW 260



 Score =  106 bits (264), Expect = 8e-23
 Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 13/241 (5%)

Query: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433
           GH D  +TC+ F   G+ + SGS D T+++W             HT  V S     +   
Sbjct: 21  GHKD-AVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQS 79

Query: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491
            ++ S D+T+KVW     + + +L  H + VRC       + +VS S D T+++WD  + 
Sbjct: 80  FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139

Query: 492 QCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
           +C+H    H   V  V +   G  + +   D  VKVWD  T   L   Q H+  V  L F
Sbjct: 140 ECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199

Query: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ--SLTSGMELKDNILVSGNADSTVKI 605
              G ++++ S D+++++ D+  G  ++TL GHQ  + T           SG +D  V +
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259

Query: 606 W 606
           W
Sbjct: 260 W 260



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 51/188 (27%), Positives = 93/188 (49%), Gaps = 11/188 (5%)

Query: 480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTL 537
           D+ L VW ++     +   GH  AV CV +   G  + SG+ D  V++W P  +      
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 538 QGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--I 593
           + HT  V S+ F  DG   V+ S D +++VW       + +L+ H +     +   +  +
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 594 LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDL 651
           +VS + D TVK+WD  + +C+ +     +H   VT + F+ +   +  +  D TVK+WD+
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYC---EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178

Query: 652 KTGEFIRN 659
           +T   +++
Sbjct: 179 RTHRLLQH 186


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  115 bits (288), Expect = 1e-25
 Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)

Query: 366 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 421
           R   L++P  +L GH+  V  C     G+ + S   D  + +W+ V G C    TL GH+
Sbjct: 51  RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109

Query: 422 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 476
           G V       +  ++ S STD+T+ VW++ETGE +  L GHTS V   +   +    V +
Sbjct: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169

Query: 477 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 535
           GS D T+++WDI     +         +     D   +++SG  D  +KVWD       +
Sbjct: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229

Query: 536 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 583
           T++GH + V   SL  +G +++S ++D ++RVWDV        C+    G+        L
Sbjct: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289

Query: 584 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 641
                   + + +G+AD  V +WD  + + L  L G   H  ++  + F+ +   +I++S
Sbjct: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346

Query: 642 DDGTVKLWDLK 652
            D  + + +++
Sbjct: 347 SDKRLYMGEIQ 357



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)

Query: 574 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 629
           I  L+GH+      +   N   L S   D  + +W++  G C    TL+G   H  AV  
Sbjct: 59  IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114

Query: 630 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660
           L +N +   + ++S D TV +WD +TGE ++ L
Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score =  114 bits (286), Expect = 2e-25
 Identities = 74/280 (26%), Positives = 130/280 (46%), Gaps = 21/280 (7%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 237 GTLLATGSYDGFARIWTK-DGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDA 295

Query: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 296 HTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAI 355

Query: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
           ++D  G  + S + D  +K+W  + + C+H LQ H   +Y++++             + +
Sbjct: 356 KWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLML 415

Query: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
            S S D+++R+WDV+ G CIHTLT HQ     +    +   L SG+ D  V IW+ +TG 
Sbjct: 416 ASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGA 475

Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 476 LVHSYRGTG--GIFEVCWNAAGDKVGASASDGSVCVLDLR 513



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 77/316 (24%), Positives = 121/316 (38%), Gaps = 71/316 (22%)

Query: 375 VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVW-------SAVTGKCLRTLVGHTGGV-- 424
           VL+GH+  V  C      + + SGS D+T ++W       S  T   LR  +   G    
Sbjct: 164 VLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVP 223

Query: 425 ---------WSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR-- 473
                    W+S+    ++ +GS D   ++W  + G    TL  H   +  +  ++K   
Sbjct: 224 SNKDVTSLDWNSE--GTLLATGSYDGFARIWTKD-GNLASTLGQHKGPIFALKWNKKGNF 280

Query: 474 VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYDFMVKVWDPETET 532
           ++S   D T  +WD  TG+       H A    V +       S + D  + V     + 
Sbjct: 281 ILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDR 340

Query: 533 CLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN 592
            + T QGHTN V ++++D                   TGN                    
Sbjct: 341 PIKTFQGHTNEVNAIKWD------------------PTGN-------------------- 362

Query: 593 ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF-------NKNFVITSSD-DG 644
           +L S + D T+KIW +K   C+  LQ  NK    +            N N ++ S+  D 
Sbjct: 363 LLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDS 422

Query: 645 TVKLWDLKTGEFIRNL 660
           TV+LWD+  G  I  L
Sbjct: 423 TVRLWDVDRGICIHTL 438


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  114 bits (284), Expect = 4e-25
 Identities = 75/258 (29%), Positives = 122/258 (47%), Gaps = 15/258 (5%)

Query: 415 RTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--H 470
           R   GH   + S  +  N   + + S D  L +WN +     +   GH   V  +    H
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71

Query: 471 EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDP 528
              + S SRD T+R+W  +          H A VR V +  DG+ + + + D  +KVW  
Sbjct: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131

Query: 529 ETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 586
             +  L++L  HT+ V   +F  DG  +VS S D +I++WD     C++  +      + 
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191

Query: 587 MELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSD 642
           ++   +   + S  +D TVK+WD++  + LQ  Q    H   V C+ F+   N++IT+S 
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ---VHSGGVNCISFHPSGNYLITASS 248

Query: 643 DGTVKLWDLKTGEFIRNL 660
           DGT+K+ DL  G  I  L
Sbjct: 249 DGTLKILDLLEGRLIYTL 266



 Score =  105 bits (262), Expect = 1e-22
 Identities = 71/241 (29%), Positives = 112/241 (46%), Gaps = 13/241 (5%)

Query: 378 GHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--I 433
           GH D V+T +QF   GN + S S D T+++W             HT  V S     +   
Sbjct: 58  GHKD-VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQF 116

Query: 434 IISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETG 491
           + + S D+++KVW+      +++LY HT  VRC       + +VS S D T+++WD    
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK 176

Query: 492 QCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF 549
           QC++     V     V ++  G  + S   D  VKVWD      L   Q H+  V  + F
Sbjct: 177 QCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF 236

Query: 550 --DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNILVSGNADSTVKI 605
              G ++++ S D ++++ D+  G  I+TL GH     T        +  SG AD+ V +
Sbjct: 237 HPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLL 296

Query: 606 W 606
           W
Sbjct: 297 W 297



 Score =  103 bits (257), Expect = 5e-22
 Identities = 81/294 (27%), Positives = 134/294 (45%), Gaps = 26/294 (8%)

Query: 374 KVLKGHDDHVITCLQFC--GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM-- 429
           +  KGH    IT L     G ++ + S D  L +W+          VGH   V S Q   
Sbjct: 12  RYFKGHKA-AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP 70

Query: 430 RDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWD 487
             N++ S S DRT+++W  +          HT+ VR +      + + + S D +++VW 
Sbjct: 71  HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWS 130

Query: 488 IETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
           +   + L+ L  H   VRC ++  DGR +VS + D  +K+WD   + C++          
Sbjct: 131 MYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190

Query: 546 SLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG------MELKDNILVSG 597
            + F+  G  + S   D +++VWDV     ++ L  H  + SG           N L++ 
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQVHSGGVNCISFHPSGNYLITA 246

Query: 598 NADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSD--DGTVKLW 649
           ++D T+KI D+  G+ + TLQG   H   V  + F+K   + +S   D  V LW
Sbjct: 247 SSDGTLKILDLLEGRLIYTLQG---HTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 26/90 (28%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 369 ELKSPKVLKGHDDHV--ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGV 424
           +++  K+L+ +  H   + C+ F   GN +++ S D TLK+   + G+ + TL GHTG V
Sbjct: 214 DVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPV 273

Query: 425 W--SSQMRDNIIISGSTDRTLKVWNAETGE 452
           +  S      +  SG  D  + +W     E
Sbjct: 274 FTVSFSKGGELFASGGADTQVLLWRTNFDE 303


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  113 bits (283), Expect = 5e-25
 Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 249 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 307

Query: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 308 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 367

Query: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
           ++D  G  + S + D  +K+W  + E C+H LQ H   +Y++++             I +
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427

Query: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
            S S D+++R+WD+E G C HTLT HQ     +    +   L SG+ D  V IW+ ++G 
Sbjct: 428 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487

Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 488 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 525



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 79/322 (24%), Positives = 125/322 (38%), Gaps = 77/322 (23%)

Query: 368 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 411
           GE++ P     VL+GH+  V  C      + + SGS D+T ++W+            V  
Sbjct: 165 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 224

Query: 412 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 463
            C+R   GH        T   W++     ++ +GS D   ++W  E G    TL  H   
Sbjct: 225 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 280

Query: 464 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 520
           +  +  + K   ++S   D T  +WD  TG+       H A    V +       S + D
Sbjct: 281 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 340

Query: 521 FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGH 580
             + V     +  + T QGHTN V ++++D                              
Sbjct: 341 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWD------------------------------ 370

Query: 581 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV-------TCLQFN 633
               SGM     +L S + D T+KIW +K   C+  LQ  NK    +            N
Sbjct: 371 ---PSGM-----LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPN 422

Query: 634 KNFVITSSD-DGTVKLWDLKTG 654
            N ++ S+  D TV+LWD++ G
Sbjct: 423 SNIMLASASFDSTVRLWDIERG 444



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)

Query: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 516
           + SGS D+T R+W++     G    +++ H     C++  G  V S              
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 250

Query: 517 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 570
               G+YD   ++W  E      TL  H   +++L+++  G +++S  +D +  +WD  T
Sbjct: 251 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 309

Query: 571 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
           G        H +    ++ ++N    S + D  + +  +   + ++T QG   H + V  
Sbjct: 310 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 366

Query: 630 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 660
           ++++ + ++ +S  DD T+K+W +K    I +L
Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 399



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)

Query: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579
           L+GH + V+   ++ +   + SGS D++ R+W++   +           CI    H +  
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236

Query: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636
           ++ +TS        +L +G+ D   +IW  + G    TL    +H+  +  L++N+  N+
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 292

Query: 637 VITSSDDGTVKLWDLKTGE 655
           ++++  D T  +WD  TGE
Sbjct: 293 ILSAGVDKTTIIWDAHTGE 311



 Score = 33.1 bits (74), Expect = 0.91
 Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)

Query: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 593
           T+ G  NR +S+     H     +D  + +      +    L GH+S           ++
Sbjct: 143 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 195

Query: 594 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 640
           L SG+ DST +IW++               C++           VT L +N N   + T 
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 255

Query: 641 SDDGTVKLW 649
           S DG  ++W
Sbjct: 256 SYDGFARIW 264


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  113 bits (283), Expect = 5e-25
 Identities = 74/280 (26%), Positives = 129/280 (46%), Gaps = 21/280 (7%)

Query: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGSTDRTLKVWNA 448
           G  + +GS D   ++W+   G    TL  H G +++ +   + N I+S   D+T  +W+A
Sbjct: 249 GTLLATGSYDGFARIWTE-DGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDA 307

Query: 449 ETGECIHTLYGHTSTVRCMHLHEKRV-VSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 507
            TGE       H++    +         S S D  + V  +   + +    GH   V  +
Sbjct: 308 HTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAI 367

Query: 508 QYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD-----------GIHV 554
           ++D  G  + S + D  +K+W  + E C+H LQ H   +Y++++             I +
Sbjct: 368 KWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIML 427

Query: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQ 612
            S S D+++R+WD+E G C HTLT HQ     +    +   L SG+ D  V IW+ ++G 
Sbjct: 428 ASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487

Query: 613 CLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLK 652
            + + +G         C     + V  S+ DG+V + DL+
Sbjct: 488 LVHSYRGTG--GIFEVCWNARGDKVGASASDGSVCVLDLR 525



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 79/322 (24%), Positives = 125/322 (38%), Gaps = 77/322 (23%)

Query: 368 GELKSPK----VLKGHDDHVITCL-QFCGNRIVSGSDDNTLKVWSA-----------VTG 411
           GE++ P     VL+GH+  V  C      + + SGS D+T ++W+            V  
Sbjct: 165 GEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLR 224

Query: 412 KCLRTLVGH--------TGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTST 463
            C+R   GH        T   W++     ++ +GS D   ++W  E G    TL  H   
Sbjct: 225 HCIRE-GGHDVPSNKDVTSLDWNTN--GTLLATGSYDGFARIWT-EDGNLASTLGQHKGP 280

Query: 464 VRCMHLHEKR--VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRV-VSGAYD 520
           +  +  + K   ++S   D T  +WD  TG+       H A    V +       S + D
Sbjct: 281 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTD 340

Query: 521 FMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGH 580
             + V     +  + T QGHTN V ++++D                              
Sbjct: 341 MCIHVCRLGCDRPVKTFQGHTNEVNAIKWD------------------------------ 370

Query: 581 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAV-------TCLQFN 633
               SGM     +L S + D T+KIW +K   C+  LQ  NK    +            N
Sbjct: 371 ---PSGM-----LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPN 422

Query: 634 KNFVITSSD-DGTVKLWDLKTG 654
            N ++ S+  D TV+LWD++ G
Sbjct: 423 SNIMLASASFDSTVRLWDIERG 444



 Score = 59.7 bits (143), Expect = 9e-09
 Identities = 47/213 (22%), Positives = 97/213 (45%), Gaps = 35/213 (16%)

Query: 474 VVSGSRDATLRVWDIE---TGQCLHVLMGHVAAVRCVQYDGRRVVS-------------- 516
           + SGS D+T R+W++     G    +++ H     C++  G  V S              
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRH-----CIREGGHDVPSNKDVTSLDWNTNGT 250

Query: 517 ----GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVWDVET 570
               G+YD   ++W  E      TL  H   +++L+++  G +++S  +D +  +WD  T
Sbjct: 251 LLATGSYDGFARIWT-EDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 309

Query: 571 GNCIHTLTGHQSLTSGMELKDNI-LVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
           G        H +    ++ ++N    S + D  + +  +   + ++T QG   H + V  
Sbjct: 310 GEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQG---HTNEVNA 366

Query: 630 LQFNKNFVITSS--DDGTVKLWDLKTGEFIRNL 660
           ++++ + ++ +S  DD T+K+W +K    I +L
Sbjct: 367 IKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 399



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 34/139 (24%), Positives = 68/139 (48%), Gaps = 24/139 (17%)

Query: 537 LQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWDVETGN-----------CI----HTLTG 579
           L+GH + V+   ++ +   + SGS D++ R+W++   +           CI    H +  
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPS 236

Query: 580 HQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NF 636
           ++ +TS        +L +G+ D   +IW  + G    TL    +H+  +  L++N+  N+
Sbjct: 237 NKDVTSLDWNTNGTLLATGSYDGFARIWT-EDGNLASTL---GQHKGPIFALKWNRKGNY 292

Query: 637 VITSSDDGTVKLWDLKTGE 655
           ++++  D T  +WD  TGE
Sbjct: 293 ILSAGVDKTTIIWDAHTGE 311



 Score = 33.1 bits (74), Expect = 0.91
 Identities = 30/129 (23%), Positives = 50/129 (38%), Gaps = 22/129 (17%)

Query: 536 TLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQS--LTSGMELKDNI 593
           T+ G  NR +S+     H     +D  + +      +    L GH+S           ++
Sbjct: 143 TVNGEENRAHSVNN---HAKPMEIDGEVEI----PSSKATVLRGHESEVFICAWNPVSDL 195

Query: 594 LVSGNADSTVKIWDIKTG-----------QCLQTLQGPNKHQSAVTCLQFNKN--FVITS 640
           L SG+ DST +IW++               C++           VT L +N N   + T 
Sbjct: 196 LASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATG 255

Query: 641 SDDGTVKLW 649
           S DG  ++W
Sbjct: 256 SYDGFARIW 264


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,992,977
Number of Sequences: 37866
Number of extensions: 1487365
Number of successful extensions: 39088
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 734
Number of HSP's successfully gapped in prelim test: 595
Number of HSP's that attempted gapping in prelim test: 12908
Number of HSP's gapped (non-prelim): 10937
length of query: 707
length of database: 18,247,518
effective HSP length: 109
effective length of query: 598
effective length of database: 14,120,124
effective search space: 8443834152
effective search space used: 8443834152
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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