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Search of human proteins with 157738649
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
(916 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 1762 0.0
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 1040 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 540 e-153
gi|14249342 internexin neuronal intermediate filament protein, a... 409 e-114
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 403 e-112
gi|62414289 vimentin [Homo sapiens] 346 6e-95
gi|21264345 peripherin [Homo sapiens] 325 2e-88
gi|55749932 desmin [Homo sapiens] 322 1e-87
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 315 2e-85
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 313 4e-85
gi|4504919 keratin 8 [Homo sapiens] 226 1e-58
gi|153791158 keratin 75 [Homo sapiens] 213 7e-55
gi|67782365 keratin 7 [Homo sapiens] 207 4e-53
gi|4557701 keratin 17 [Homo sapiens] 204 2e-52
gi|155969697 keratin 6C [Homo sapiens] 203 7e-52
gi|119395754 keratin 5 [Homo sapiens] 202 9e-52
gi|24430192 keratin 16 [Homo sapiens] 201 3e-51
gi|119703753 keratin 6B [Homo sapiens] 201 3e-51
gi|5031839 keratin 6A [Homo sapiens] 200 4e-51
gi|195972866 keratin 10 [Homo sapiens] 200 6e-51
gi|109255249 keratin 4 [Homo sapiens] 199 1e-50
gi|15431316 keratin, hair, basic, 4 [Homo sapiens] 198 2e-50
gi|15431310 keratin 14 [Homo sapiens] 197 4e-50
gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo sap... 196 8e-50
gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo sap... 196 8e-50
gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo sap... 196 8e-50
gi|27477127 keratin 82 [Homo sapiens] 196 8e-50
gi|14318422 keratin 86 [Homo sapiens] 196 8e-50
gi|4504935 keratin 85 [Homo sapiens] 195 1e-49
gi|169790853 keratin, hair, basic, 1 [Homo sapiens] 194 2e-49
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 1762 bits (4563), Expect = 0.0
Identities = 916/916 (100%), Positives = 916/916 (100%)
Query: 1 MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPR 60
MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPR
Sbjct: 1 MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPR 60
Query: 61 LAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVH 120
LAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVH
Sbjct: 61 LAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVH 120
Query: 121 YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE 180
YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE
Sbjct: 121 YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE 180
Query: 181 DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE 240
DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE
Sbjct: 181 DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE 240
Query: 241 EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT 300
EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT
Sbjct: 241 EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT 300
Query: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ 360
EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ
Sbjct: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ 360
Query: 361 DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSIT 420
DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSIT
Sbjct: 361 DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSIT 420
Query: 421 GPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEEL 480
GPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEEL
Sbjct: 421 GPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEEL 480
Query: 481 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED 540
AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED
Sbjct: 481 AVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEED 540
Query: 541 EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600
EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE
Sbjct: 541 EGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEE 600
Query: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP 660
LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP 660
Query: 661 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 720
VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK
Sbjct: 661 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 720
Query: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 780
KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE
Sbjct: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 780
Query: 781 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 840
GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD
Sbjct: 781 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 840
Query: 841 EKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV 900
EKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV
Sbjct: 841 EKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKV 900
Query: 901 EKVTSHAIVKEVTQSD 916
EKVTSHAIVKEVTQSD
Sbjct: 901 EKVTSHAIVKEVTQSD 916
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 1040 bits (2688), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 377 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 436
MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI
Sbjct: 1 MARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKI 60
Query: 437 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 496
QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE
Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 497 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 556
EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
Query: 557 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 616
GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP 240
Query: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 676
VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE 300
Query: 677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 736
KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES
Sbjct: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAES 360
Query: 737 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 796
PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR
Sbjct: 361 PVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
Query: 797 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 856
KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK
Sbjct: 421 KEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTK 480
Query: 857 TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 916
TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD
Sbjct: 481 TVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEKVTSHAIVKEVTQSD 540
Score = 78.6 bits (192), Expect = 3e-14
Identities = 126/524 (24%), Positives = 200/524 (38%), Gaps = 82/524 (15%)
Query: 248 QIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNK 307
+++A + V+ K + T +++ +S++E + EE + EAAE+ +
Sbjct: 64 KVEAPKLKVQHKFVEEIIEETKVEDEKSEME---EALTAITEELAVSMKEEKKEAAEEKE 120
Query: 308 EAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLE 367
E + +EE+A + +++ + E++ G KE E Q EE D + D ++
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQ----EEEEEEDEGAKSDQAEEGG 176
Query: 368 NELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHR 427
+E G+ + K + E EGEE
Sbjct: 177 SEKEGS---------------SEKEEGEQEEGETEAEAEGEEAEAK-------------- 207
Query: 428 PPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEE 487
++ KVE +V K EE++ + KVE + + EE S
Sbjct: 208 ---------EEKKVEEKSEEVATK--EELVADAKVEKPEKAKSPVPKSPVEEKGKS--PV 254
Query: 488 KKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ 547
K EEK + P + KSPV + EE+G+ + EE+ + KS
Sbjct: 255 PKSPVEEKGKSPVPKSPVEEKGKSPVPKSP---VEEKGKSPVSKSPVEEKAKSPVPKSPV 311
Query: 548 AEEGGSEKEGSSE-KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAK 606
E + G E KEE E+E E E + E+ E K + E+K E KEE VA+
Sbjct: 312 EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV- 370
Query: 607 VEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 666
V + K + K +E+GK + E+ G + +KG K + G+
Sbjct: 371 VTITKSVKVHLEKE-TKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGE 429
Query: 667 SPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE----APKEEKV--EK 720
K VE++ K KG +EEE+ V +P +EK +K
Sbjct: 430 VE-GKEEVEQETKE-----------------KGSGREEEKGVVTNGLDLSPADEKKGGDK 471
Query: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE 764
EEK V K E E ITKSV V + E EE
Sbjct: 472 SEEK---VVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEE 512
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 540 bits (1392), Expect = e-153
Identities = 402/973 (41%), Positives = 546/973 (56%), Gaps = 118/973 (12%)
Query: 25 SRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQSSSLL 84
+R + SSGF S W+R S S+VS+S R + A +S+ SLD +L
Sbjct: 37 TRSAAGSSSGFHS--WTRTSVSSVSASPSR--------FRGAGAASSTDSLD-----TLS 81
Query: 85 NGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHA 144
NG G SRS EKEQLQ LNDRFAGYI+KV LE N+ +E E ALRQ+QA +
Sbjct: 82 NGPEGCMVAVATSRS-EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRS 140
Query: 145 QLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIR 204
+G+ Y++E+RE+R + + + Q++L+ +HL EDI +++R ++EAR R++ EAA R
Sbjct: 141 AMGELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAAR 200
Query: 205 ALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQAS-----HITVERK 259
AL + +EA +V+L KK Q+LQ+E +LR +H+EEV +LL QIQ S + E +
Sbjct: 201 ALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETR 260
Query: 260 DYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAE 319
D LK D+++AL+EIR+QLE H+ Q+ Q+EEWF+ R +L+EAA+ N +A+RSA+EEI E
Sbjct: 261 DALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITE 320
Query: 320 YRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMAR 379
YRRQLQ+++ ELE+++ TK+SLERQ S++E+RH D++SYQ+ IQQL+ ELR TKWEMA
Sbjct: 321 YRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAA 380
Query: 380 HLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKP 439
LREYQDLLNVKMALDIEIAAYRKLLEGEE R G I L P I S K
Sbjct: 381 QLREYQDLLNVKMALDIEIAAYRKLLEGEECRIG--FGPIPFSLPEGLPKIPSVSTHIKV 438
Query: 440 KVEAPKLKVQHK------FVEEIIEETKVEDEKSEMEEALTAITE-ELAVSMKEEKKEAA 492
K E K+KV K VEE EET+V +E +E EE E + +EE+ E
Sbjct: 439 KSE-EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 493 EEKEEEPEAEEEEVAAK--KSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
EE+ + P AEE K KSPVK A E + ++EE E + E AKS EE
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 551 GGSEKEGSS-EKEEGE---------------QEEGETEAEAEGEEAEAKEEKKVEEKSEE 594
S E S EKEE + +EE ++ AEA+ E +AK K E KS
Sbjct: 558 AKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE-KAKSPVKEEAKSPA 616
Query: 595 VA---TKEELVADAKVEKPEKAKSPV---------PKSPVEEKGKSP-VPKSPVE----- 636
A KEE + A+V+ PEKAKSP KSP +E+ KSP KSPV+
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS 676
Query: 637 -EKGKSPV---------PKSPVEEKGKSP-VPKSPVEEKGKSP-VSKSPVEEKAKSP-VP 683
EK KSPV KSPV+E+ KSP KSPV+E+ KSP +KSPV+E+AK+P
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA 736
Query: 684 KSPVEEAKSKAEVGKGEQK----EEEEKEVKEAPKEE------KVEKKEEKP--KDVPEK 731
KSPV+E E K +K + + E K KEE K +K + P ++V
Sbjct: 737 KSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSP 796
Query: 732 KKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQ-------QEKEKEKAGGEGGSE 784
+KA+SP+KE+A A I K K ++ KEE KP + ++ E+EKA +E
Sbjct: 797 EKAKSPLKEDAKAPEKEIPK--KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE 854
Query: 785 EEGSDKGAKGSRKEDIAVNGEVEGKEE--VEQETKEKGSGREEE----KGVVTNGLDLSP 838
E+ K + +KE A +VE K+E VE+ + K ++EE K V T +
Sbjct: 855 EKKDSKKEEAPKKE--APKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPA 912
Query: 839 ADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTK 898
E K K +EK V K E D K +K + E ++T EEK + K
Sbjct: 913 KVEVKEDAKPKEKTEVAK------KEPDDAKAKEPSKPAEKKEAAPEKKDTKEEK--AKK 964
Query: 899 KVEKVTSHAIVKE 911
EK + A KE
Sbjct: 965 PEEKPKTEAKAKE 977
Score = 122 bits (307), Expect = 1e-27
Identities = 205/861 (23%), Positives = 327/861 (37%), Gaps = 152/861 (17%)
Query: 97 SRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQAS-HAQLGDAYDQEI- 154
+R + +++ Q L + GY+ + H +++ E+ +IQ QA A+ DA ++
Sbjct: 212 ARVDLQKKAQALQEE-CGYLRRHH--QEEVGELLGQIQGSGAAQAQMQAETRDALKCDVT 268
Query: 155 ---RELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIE 211
RE+RA LE H + + RL E + + I R+ ++
Sbjct: 269 SALREIRAQLE--GHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQ 326
Query: 212 EASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALK 271
+ L SL+ + + L H+ ++A IQ L ++
Sbjct: 327 ARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ----------LDAELRNTKW 376
Query: 272 EIRSQLESHSDQ-NMHQAEEWFKCRYAKLTEAAEQN--------------------KEAI 310
E+ +QL + D N+ A + Y KL E E I
Sbjct: 377 EMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHI 436
Query: 311 RSAKEEIAEYRRQLQSKSI----ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQL 366
+ EE + + + +++ + E + T+E E + + +E + ++ ++
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE--EEA 494
Query: 367 ENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTH 426
E TK A + + + + A K E EE + S
Sbjct: 495 EGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPA 554
Query: 427 RPPITISSKIQKPKVEAPKLKVQHKFVEEII----EETKVEDEKSEMEEALTAITEELAV 482
+ + + P+ E K + K E+ EE K E E+A + + EE
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614
Query: 483 S------MKEEKKEAAE----EKEEEPEAEEEEVAAK---------KSPVKATAPEVKEE 523
+KEE K AE EK + P EE + K KSP KA +P E
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGS-EKEGSSEKEEGE---------QEEGETEA 573
+ ++ + + E + E AKS EE S EK S KEE + +EE +T
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPE 734
Query: 574 EAEG---EEAEAKEEKKVEEKSE---------EVATKEELVADA-------------KVE 608
+A+ EEA++ E+ K EK++ + KEE + A +V+
Sbjct: 735 KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVK 794
Query: 609 KPEKAKSPVPKS--------PVEEKGKSPV--PKSPVEEKGKSPVPKSPVEEKGKSPVPK 658
PEKAKSP+ + P +E+ KSPV + P E K K P PK EEK P
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP-PKKAEEEK----APA 849
Query: 659 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 718
+P E+ K S EE K PK VEE K A E PKE KV
Sbjct: 850 TPKTEEKKD----SKKEEAPKKEAPKPKVEEKKEPA---------------VEKPKESKV 890
Query: 719 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAG 778
E K+E+ +D KKK +P KE V+V + + KE+ + ++E + KA
Sbjct: 891 EAKKEEAED---KKKVPTPEKEAPA--------KVEVKEDAKPKEKTEVAKKEPDDAKAK 939
Query: 779 GEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSP 838
E+ K KE+ A E + K E + + +K +E K S
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSS 999
Query: 839 ADEKKGGDKSEEKVVVTKTVE 859
D+K K EK K +
Sbjct: 1000 TDQK--DSKPPEKATEDKAAK 1018
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 409 bits (1052), Expect = e-114
Identities = 240/498 (48%), Positives = 338/498 (67%), Gaps = 26/498 (5%)
Query: 8 LGNPSAYRRVTETRSSFS-RVSGSPSSG-FRSQSWSRGSPSTVSSSYKRSMLAPRLAYSS 65
L + S+YR+V S S R+SG+ +G FRSQS SR + ++ ++ S L LAY
Sbjct: 9 LCSSSSYRKVFGDGSRLSARLSGAGGAGGFRSQSLSRSNVASSAACSSASSLGLGLAYRR 68
Query: 66 AMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQ 125
A LD SQ+++ N +YK+ R+NEKEQLQGLNDRFA +IEKVH LE Q
Sbjct: 69 P---PASDGLDLSQAAARTN-------EYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQ 118
Query: 126 NKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRL 185
N+ +EAE+ ALRQ+ A +++G+ + +E+R+LRA LE + ++Q L+ D L E++ RL
Sbjct: 119 NRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERDGLAEEVQRL 178
Query: 186 KERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADL 245
+ R EEE+R R+ E A++A ++D++ A+L +++L+KKV+SL DE+AF+R H+EEVA+L
Sbjct: 179 RARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAEL 238
Query: 246 LAQIQASHITVERKDYL--KTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAA 303
LA +QAS D K D+++AL+EIR+Q ES + +N+ AEEW+K ++A L E A
Sbjct: 239 LATLQASSQAAAEVDVTVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQA 298
Query: 304 EQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTI 363
++ EAIR+++EEI EYRRQLQ+++IE+E +RG ESLERQ+ ++EERH+ +++ YQD+I
Sbjct: 299 ARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSI 358
Query: 364 QQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITG-- 421
QLEN+LR TK EMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFST SI+G
Sbjct: 359 GQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLN 418
Query: 422 ----PLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEK-SEMEEALTAI 476
P Y PP +S+ K LK + EE E +KV +K S++ E+ I
Sbjct: 419 PLPNPSYL-LPPRILSATTSKVSSTGLSLKKE----EEEEEASKVASKKTSQIGESFEEI 473
Query: 477 TEELAVSMKEEKKEAAEE 494
EE +S K+ +K EE
Sbjct: 474 LEETVISTKKTEKSNIEE 491
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 403 bits (1036), Expect = e-112
Identities = 245/563 (43%), Positives = 352/563 (62%), Gaps = 24/563 (4%)
Query: 2 SYTLDSLGNPSAYRRVTET-RSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPR 60
S++ + + S RR ET R S V S+ RS S +P + S S +RS +
Sbjct: 3 SFSYEPYYSTSYKRRYVETPRVHISSVRSGYSTA-RSAYSSYSAPVSSSLSVRRSYSS-- 59
Query: 61 LAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVH 120
SS L + +LD SQ +++ N D K R+ EK QLQ LNDRFA +IE+VH
Sbjct: 60 ---SSGSLMPSLENLDLSQVAAISN-------DLKSIRTQEKAQLQDLNDRFASFIERVH 109
Query: 121 YLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEE 180
LEQQNK +EAE+ LRQK + ++ Y+QEIR+LR E +EK +Q + + LEE
Sbjct: 110 ELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEE 169
Query: 181 DIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEE 240
+ L+ R+EEE R+D E + RK +EA+L + EL+K++ SL DE++FL+ HEE
Sbjct: 170 TLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEE 229
Query: 241 EVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLT 300
E+A+L AQIQ + I+VE D K D+S ALK+IR+Q E + +NM AEEWFK R+ LT
Sbjct: 230 EIAELQAQIQYAQISVEM-DVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLT 288
Query: 301 EAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQ 360
E+A +N +A+R+AK+E++E RR L++K++E+E+ RG E+LE+QL ++E++ N D+S+ Q
Sbjct: 289 ESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQ 348
Query: 361 DTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS-TFAGSI 419
DTI +LENELR TK EMAR+L+EYQDLLNVKMALDIEIAAYRKLLEGEETR S T GSI
Sbjct: 349 DTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSI 408
Query: 420 TGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEE 479
T Y+ + S + + + + + V++E+ E+EE + A E
Sbjct: 409 TSG-YSQSSQVFGRSAYGGLQTSSYLMSTRS---FPSYYTSHVQEEQIEVEETIEAAKAE 464
Query: 480 LAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE 539
A + EA EE++++ EAEEEE A ++ K + E KEEE E EEG+E +E E
Sbjct: 465 EAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAE 524
Query: 540 DEGAKSDQAEEGGSEKEGSSEKE 562
+E ++ EG E++ + +K+
Sbjct: 525 EE----EKKVEGAGEEQAAKKKD 543
Score = 64.3 bits (155), Expect = 5e-10
Identities = 98/495 (19%), Positives = 193/495 (38%), Gaps = 68/495 (13%)
Query: 266 ISTALKEIRSQ----LESHSD------QNMHQAEEWFKCRYAKLTEAAEQNKEAIRSA-- 313
IS LK IR+Q L+ +D + +H+ E+ K A+L +++ E R
Sbjct: 79 ISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRAL 138
Query: 314 -KEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRG 372
++EI + R + + E ++++G +E LE L +++ R+ ++ S +D +L +G
Sbjct: 139 YEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKG 198
Query: 373 TKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITI 432
E A E + ++ M EI+ +K+ E E I++
Sbjct: 199 AD-EAALARAELEKRIDSLMD---EISFLKKVHEEEIAELQA---------QIQYAQISV 245
Query: 433 SSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAA 492
+ KP + A ++ ++ E + +++ + + T +TE +A
Sbjct: 246 EMDVTKPDLSAALKDIRAQY--EKLAAKNMQNAEEWFKSRFTVLTE------------SA 291
Query: 493 EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGG 552
+ + A ++EV+ + +KA E++ G E E Q +E E+ + A ++
Sbjct: 292 AKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTI 351
Query: 553 SEKEGSSEKEEGEQEEGETEAE-------------------AEGEEAEAKEEKKVEEKSE 593
++ E + E E + EGEE V +
Sbjct: 352 NKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTS-VGSITS 410
Query: 594 EVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK 653
+ ++ + + + + S V + +E + + + EE
Sbjct: 411 GYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVE--ETIEAAKAEEAKD 468
Query: 654 SPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGE------QKEEEEK 707
P + EE+ K E + K EEAK + E G+GE + EEEEK
Sbjct: 469 EPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEK 528
Query: 708 EVKEAPKEEKVEKKE 722
+V+ A +E+ +KK+
Sbjct: 529 KVEGAGEEQAAKKKD 543
Score = 47.0 bits (110), Expect = 8e-05
Identities = 36/123 (29%), Positives = 57/123 (46%), Gaps = 33/123 (26%)
Query: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 762
+EE+ EV+E + K E+ +++P P + +AE K++ AE E+E
Sbjct: 448 QEEQIEVEETIEAAKAEEAKDEP---PSEGEAEEEEKDKEEAE------------EEEAA 492
Query: 763 EEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSG 822
EE + ++E E+ K EGG EEG E KE E+E K +G+G
Sbjct: 493 EEEEAAKEESEEAKEEEEGGEGEEGE------------------ETKEAEEEEKKVEGAG 534
Query: 823 REE 825
E+
Sbjct: 535 EEQ 537
Score = 30.8 bits (68), Expect = 6.0
Identities = 21/87 (24%), Positives = 37/87 (42%), Gaps = 1/87 (1%)
Query: 785 EEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKG 844
EE + K++ GE E +EE ++E E+ EEE+ + +E
Sbjct: 455 EETIEAAKAEEAKDEPPSEGEAE-EEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGE 513
Query: 845 GDKSEEKVVVTKTVEKITSEGGDGATK 871
G++ EE + +K+ G + A K
Sbjct: 514 GEEGEETKEAEEEEKKVEGAGEEQAAK 540
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 346 bits (887), Expect = 6e-95
Identities = 190/414 (45%), Positives = 289/414 (69%), Gaps = 22/414 (5%)
Query: 12 SAYRRVTETRSSFSRVSGSPSSGFRS-QSWSRGS---PSTVSSSYKRS--------MLAP 59
S+YRR+ + SR S S S S +++S GS PST S Y S A
Sbjct: 9 SSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAV 68
Query: 60 RLAYSSAMLSSAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKV 119
RL S + + S+DFS + ++ ++K +R+NEK +LQ LNDRFA YI+KV
Sbjct: 69 RLRSSVPGVRLLQDSVDFSLADAI-------NTEFKNTRTNEKVELQELNDRFANYIDKV 121
Query: 120 HYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLE 179
+LEQQNK + AE++ L+ + S +LGD Y++E+RELR ++ + ++KA+V+++ D+L
Sbjct: 122 RFLEQQNKILLAELEQLKGQGKS--RLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLA 179
Query: 180 EDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHE 239
EDI RL+E+ +EE R++ E +++ R+D++ ASL +++L++KV+SLQ+E+AFL+ HE
Sbjct: 180 EDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHE 239
Query: 240 EEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKL 299
EE+ +L AQIQ H+ ++ D K D++ AL+++R Q ES + +N+ +AEEW+K ++A L
Sbjct: 240 EEIQELQAQIQEQHVQID-VDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADL 298
Query: 300 TEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSY 359
+EAA +N +A+R AK+E EYRRQ+QS + E+++++GT ESLERQ+ ++EE + ++Y
Sbjct: 299 SEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANY 358
Query: 360 QDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS 413
QDTI +L++E++ K EMARHLREYQDLLNVKMALDIEIA YRKLLEGEE+R S
Sbjct: 359 QDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRIS 412
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 325 bits (832), Expect = 2e-88
Identities = 196/472 (41%), Positives = 297/472 (62%), Gaps = 32/472 (6%)
Query: 12 SAYRRVTETRSSFSRVSGSPSSGFR-SQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSS 70
++YRR S S + S SS R S S GS S SS S +PR A + A+L
Sbjct: 15 TSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSASPSSSVRLGSFRSPR-AGAGALLRL 73
Query: 71 AESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIE 130
LDFS + +L ++ +RSNEK++LQ LNDRFA +IEKV +LEQQN +
Sbjct: 74 PSERLDFSMAEAL-------NQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALR 126
Query: 131 AEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFE 190
E+ R ++ + A QE+RELR LE++ E+ +VQ++ D L ED+ LK+R E
Sbjct: 127 GELSQARGQEPARAD--QLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLE 184
Query: 191 EEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQ 250
EE R R+D E + RKD+++A+L ++EL++K++SL DE+ FL+ HEEE+ DL ++
Sbjct: 185 EETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVE 244
Query: 251 ASHIT-VERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEA 309
+ + VE + +K +++ AL++IR+Q ES + +N+ +AEEW+K +YA L++AA +N EA
Sbjct: 245 SQQVQQVEVEATVKPELTAALRDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEA 304
Query: 310 IRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENE 369
+R AK+E+ E RRQ+QS + E++ +RGT E+L RQL ++EE+ + YQ +LE E
Sbjct: 305 LRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEE 364
Query: 370 LRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPP 429
LR K EMARHLREYQ+LLNVKMALDIEIA YRKLLEGEE+R S P+++
Sbjct: 365 LRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISV-------PVHSF--- 414
Query: 430 ITISSKIQKPKVEAPKLKVQHKFV---------EEIIEETKVEDEKSEMEEA 472
+++ K P+VE P+ K V E++ E++ ++++SE++++
Sbjct: 415 ASLNIKTTVPEVEPPQDSHSRKTVLIKTIETRNGEVVTESQ-KEQRSELDKS 465
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 322 bits (824), Expect = 1e-87
Identities = 185/479 (38%), Positives = 299/479 (62%), Gaps = 25/479 (5%)
Query: 1 MSYTLDSLGNPSAYRRVTETRSSFSRVSGSPSSGF-RSQSWSRGSPSTVSSSYKR----- 54
MS S S+YRR F S S F R+ S+GS S+V+S +
Sbjct: 1 MSQAYSSSQRVSSYRRTFGGAPGFPLGSPLSSPVFPRAGFGSKGSSSSVTSRVYQVSRTS 60
Query: 55 -------SMLAPRLAYSSAMLS-SAESSLDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQ 106
S+ A RL + S A LDFS + ++ ++ +R+NEK +LQ
Sbjct: 61 GGAGGLGSLRASRLGTTRTPSSYGAGELLDFSLADAV-------NQEFLTTRTNEKVELQ 113
Query: 107 GLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNH 166
LNDRFA YIEKV +LEQQN + AE+ L+ ++ + ++ + Y++E+RELR +E++ +
Sbjct: 114 ELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPT--RVAELYEEELRELRRQVEVLTN 171
Query: 167 EKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQS 226
++A+V ++ D+L +D+ RLK + +EE +L+++ E + A R D++ A+L +++L+++++S
Sbjct: 172 QRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLERRIES 231
Query: 227 LQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMH 286
L +E+AFL+ HEEE+ +L AQ+Q + VE D K D++ AL++IR+Q E+ + +N+
Sbjct: 232 LNEEIAFLKKVHEEEIRELQAQLQEQQVQVEM-DMSKPDLTAALRDIRAQYETIAAKNIS 290
Query: 287 QAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLS 346
+AEEW+K + + LT+AA +N +A+R AK+E+ EYR Q+QS + E+++++GT +SL RQ+
Sbjct: 291 EAEEWYKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMR 350
Query: 347 DIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLE 406
++E+R + S YQD I +LE E+R K EMARHLREYQDLLNVKMALD+EIA YRKLLE
Sbjct: 351 ELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLE 410
Query: 407 GEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDE 465
GEE+R + + + + P S++ K K ++ + E + E T+ + E
Sbjct: 411 GEESRINLPIQTYSALNFRETSPEQRGSEVHTKKTVMIK-TIETRDGEVVSEATQQQHE 468
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 315 bits (806), Expect = 2e-85
Identities = 175/395 (44%), Positives = 261/395 (66%), Gaps = 23/395 (5%)
Query: 75 LDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQ 134
+DFS + +L G +K +R++E+ ++ LNDRFA YIEKV +LEQQNK + AE+
Sbjct: 50 VDFSLAGALNAG-------FKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELN 102
Query: 135 ALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194
LR K+ + +L D Y E+RELR L+ + A+++++ D+L +D+ ++++ ++E
Sbjct: 103 QLRAKEPT--KLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETN 160
Query: 195 LRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHI 254
LR + E + A R++ +EA+L +++L++K++SL++E+ FLR HEEEV +L Q+ +
Sbjct: 161 LRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQV 220
Query: 255 TVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAK 314
VE D K D++ ALKEIR+Q E+ + NMH+AEEW++ ++A LT+AA +N E +R AK
Sbjct: 221 HVEL-DVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAK 279
Query: 315 EEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTK 374
E +YRRQLQS + +LES+RGT ESLERQ+ + EERH + +SYQ+ + +LE E + K
Sbjct: 280 HEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLK 339
Query: 375 WEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISS 434
EMARHL+EYQDLLNVK+ALDIEIA YRKLLEGEE R IT P+ T +
Sbjct: 340 DEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENR-------ITIPVQTFSNLQIRET 392
Query: 435 KIQKPKVEAPKLK--VQHKFVE----EIIEETKVE 463
+ V LK + K VE E+I+E+K E
Sbjct: 393 SLDTKSVSEGHLKRNIVVKTVEMRDGEVIKESKQE 427
Score = 38.9 bits (89), Expect = 0.022
Identities = 59/306 (19%), Positives = 127/306 (41%), Gaps = 32/306 (10%)
Query: 295 RYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNH 354
R ++ E E N + S E++ +Q ++ + EL +R + + +L+D+ +
Sbjct: 66 RASERAEMMELN-DRFASYIEKVRFLEQQNKALAAELNQLRAKEPT---KLADVYQAELR 121
Query: 355 DLSSYQDTIQ----QLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEET 410
+L D + +LE E ++A ++ QD N+++ + +AAYR+ E +E
Sbjct: 122 ELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQ--EADEA 179
Query: 411 RFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEME 470
+ + + KI+ + E L+ H EE + E + + + ++
Sbjct: 180 TLAR---------------LDLERKIESLEEEIRFLRKIH---EEEVRELQEQLARQQVH 221
Query: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
L +L ++KE + + EE +K + + A + E ++ +
Sbjct: 222 VELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAA--ARNAELLRQAK 279
Query: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
+ + + D G+ + S E++ EQEE A +EA A+ E++ +
Sbjct: 280 HEANDYRRQLQSLTCDLESLRGTNE--SLERQMREQEERHVREAASYQEALARLEEEGQS 337
Query: 591 KSEEVA 596
+E+A
Sbjct: 338 LKDEMA 343
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 313 bits (803), Expect = 4e-85
Identities = 160/339 (47%), Positives = 240/339 (70%), Gaps = 10/339 (2%)
Query: 75 LDFSQSSSLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQ 134
+DFS + +L G +K +R++E+ ++ LNDRFA YIEKV +LEQQNK + AE+
Sbjct: 50 VDFSLAGALNAG-------FKETRASERAEMMELNDRFASYIEKVRFLEQQNKALAAELN 102
Query: 135 ALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR 194
LR K+ + +L D Y E+RELR L+ + A+++++ D+L +D+ ++++ ++E
Sbjct: 103 QLRAKEPT--KLADVYQAELRELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETN 160
Query: 195 LRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHI 254
LR + E + A R++ +EA+L +++L++K++SL++E+ FLR HEEEV +L Q+ +
Sbjct: 161 LRLEAENNLAAYRQEADEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQV 220
Query: 255 TVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAK 314
VE D K D++ ALKEIR+Q E+ + NMH+AEEW++ ++A LT+AA +N E +R AK
Sbjct: 221 HVEL-DVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAK 279
Query: 315 EEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTK 374
E +YRRQLQS + +LES+RGT ESLERQ+ + EERH + +SYQ+ + +LE E + K
Sbjct: 280 HEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLK 339
Query: 375 WEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFS 413
EMARHL+EYQDLLNVK+ALDIEIA YRKLLEGEE R +
Sbjct: 340 DEMARHLQEYQDLLNVKLALDIEIATYRKLLEGEENRIT 378
Score = 38.9 bits (89), Expect = 0.022
Identities = 59/306 (19%), Positives = 127/306 (41%), Gaps = 32/306 (10%)
Query: 295 RYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNH 354
R ++ E E N + S E++ +Q ++ + EL +R + + +L+D+ +
Sbjct: 66 RASERAEMMELN-DRFASYIEKVRFLEQQNKALAAELNQLRAKEPT---KLADVYQAELR 121
Query: 355 DLSSYQDTIQ----QLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEET 410
+L D + +LE E ++A ++ QD N+++ + +AAYR+ E +E
Sbjct: 122 ELRLRLDQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQ--EADEA 179
Query: 411 RFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEME 470
+ + + KI+ + E L+ H EE + E + + + ++
Sbjct: 180 TLAR---------------LDLERKIESLEEEIRFLRKIH---EEEVRELQEQLARQQVH 221
Query: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
L +L ++KE + + EE +K + + A + E ++ +
Sbjct: 222 VELDVAKPDLTAALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAA--ARNAELLRQAK 279
Query: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
+ + + D G+ + S E++ EQEE A +EA A+ E++ +
Sbjct: 280 HEANDYRRQLQSLTCDLESLRGTNE--SLERQMREQEERHVREAASYQEALARLEEEGQS 337
Query: 591 KSEEVA 596
+E+A
Sbjct: 338 LKDEMA 343
>gi|4504919 keratin 8 [Homo sapiens]
Length = 483
Score = 226 bits (575), Expect = 1e-58
Identities = 131/415 (31%), Positives = 231/415 (55%), Gaps = 36/415 (8%)
Query: 20 TRSSFSRVSGSPSSGFRSQSWSRGSPSTVSSSYKRSMLAPRLAYSSAMLSSAESSLDFSQ 79
T+ S+ +VS S F S+S++ G S +SSS ++S S+ L
Sbjct: 6 TQKSY-KVSTSGPRAFSSRSYTSGPGSRISSS----------SFSRVGSSNFRGGLGGGY 54
Query: 80 SSSLLNGGSGPGG--------------------DYKLSRSNEKEQLQGLNDRFAGYIEKV 119
G SG GG + + R+ EKEQ++ LN++FA +I+KV
Sbjct: 55 G-----GASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKV 109
Query: 120 HYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLE 179
+LEQQNK +E + L+Q++ + + + + ++ I LR LE + EK +++ + +++
Sbjct: 110 RFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQ 169
Query: 180 EDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHE 239
+ K ++E+E R + E ++KD++EA + KVEL+ +++ L DE+ FLR +E
Sbjct: 170 GLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYE 229
Query: 240 EEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKL 299
EE+ +L +QI + + + + D+ + + E+++Q E ++++ +AE ++ +Y +L
Sbjct: 230 EEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEEL 289
Query: 300 TEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSY 359
A ++ + +R K EI+E R + E+E ++G + SLE ++D E+R +
Sbjct: 290 QSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDA 349
Query: 360 QDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFST 414
+ +LE L+ K +MAR LREYQ+L+NVK+ALDIEIA YRKLLEGEE+R +
Sbjct: 350 NAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLES 404
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 213 bits (542), Expect = 7e-55
Identities = 114/319 (35%), Positives = 196/319 (61%), Gaps = 4/319 (1%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHA---QLGDAYDQEI 154
R+ E+EQ++ LN++FA +I+KV +LEQQNK +E + AL Q+Q S L +D
Sbjct: 146 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETK-WALLQEQGSRTVRQNLEPLFDSYT 204
Query: 155 RELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEAS 214
ELR LE + E+ +++ + ++++ + K R+E+E R E AL+KD++ A
Sbjct: 205 SELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAY 264
Query: 215 LVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIR 274
+ KVEL+ KV+SL +E+ F+ S + E++ L Q+ + + + + D+ + + E++
Sbjct: 265 MNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVK 324
Query: 275 SQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESV 334
+Q E ++++ +AE W++ +Y +L A ++ + +R+ K+EI+E R +Q E++SV
Sbjct: 325 AQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSV 384
Query: 335 RGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMAL 394
+ SL+ ++D E+R L + + LE L+ K +MAR LREYQ+L+N+K+AL
Sbjct: 385 KKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLAL 444
Query: 395 DIEIAAYRKLLEGEETRFS 413
D+EIA YRKLLEGEE R S
Sbjct: 445 DVEIATYRKLLEGEECRLS 463
>gi|67782365 keratin 7 [Homo sapiens]
Length = 469
Score = 207 bits (527), Expect = 4e-53
Identities = 109/317 (34%), Positives = 193/317 (60%), Gaps = 1/317 (0%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALR-QKQASHAQLGDAYDQEIRE 156
R E EQ++ LN++FA +I+KV +LEQQNK +E + L+ QK A ++L D ++ +I
Sbjct: 88 RQEESEQIKTLNNKFASFIDKVRFLEQQNKLLETKWTLLQEQKSAKSSRLPDIFEAQIAG 147
Query: 157 LRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLV 216
LR LE + + +++ + +++ + K ++E+E R E L+KD++ A +
Sbjct: 148 LRGQLEALQVDGGRLEAELRSMQDVVEDFKNKYEDEINHRTAAENEFVVLKKDVDAAYMS 207
Query: 217 KVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQ 276
KVEL+ KV +L DE+ FLR+ +E E+ +L +QI + + + + D+ + E+++Q
Sbjct: 208 KVELEAKVDALNDEINFLRTLNETELTELQSQISDTSVVLSMDNSRSLDLDGIIAEVKAQ 267
Query: 277 LESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRG 336
E + + +AE W++ ++ L A ++ + +R+ + EI+E R +Q E+++++
Sbjct: 268 YEEMAKCSRAEAEAWYQTKFETLQAQAGKHGDDLRNTRNEISEMNRAIQRLQAEIDNIKN 327
Query: 337 TKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDI 396
+ LE +++ EER L + ++LE L+ K +MAR LREYQ+L++VK+ALDI
Sbjct: 328 QRAKLEAAIAEAEERGELALKDARAKQEELEAALQRGKQDMARQLREYQELMSVKLALDI 387
Query: 397 EIAAYRKLLEGEETRFS 413
EIA YRKLLEGEE+R +
Sbjct: 388 EIATYRKLLEGEESRLA 404
>gi|4557701 keratin 17 [Homo sapiens]
Length = 432
Score = 204 bits (520), Expect = 2e-52
Identities = 146/425 (34%), Positives = 220/425 (51%), Gaps = 16/425 (3%)
Query: 35 FRSQSWSRGSPSTVSSSYKRSM-LAPRLAYSSAMLSSAE---SSLDFSQSSSLLNGGSGP 90
F S S +GS S + S L+ L S L SA S+L S SS + GSG
Sbjct: 8 FTSSSSIKGSSGLGGGSSRTSCRLSGGLGAGSCRLGSAGGLGSTLGGSSYSSCYSFGSGG 67
Query: 91 G------GDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQA-SH 143
G G L EK +Q LNDR A Y++KV LE+ N E+E +I+ Q+QA
Sbjct: 68 GYGSSFGGVDGLLAGGEKATMQNLNDRLASYLDKVRALEEANTELEVKIRDWYQRQAPGP 127
Query: 144 AQLGDAYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAI 203
A+ Y + I EL+ + + A + L D+ + +FE E LR EA I
Sbjct: 128 ARDYSQYYRTIEELQNKILTATVDNANILLQIDNARLAADDFRTKFETEQALRLSVEADI 187
Query: 204 RALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLK 263
LR+ ++E +L + +L+ ++++L++E+A+L+ NHEEE+ L Q+ I VE
Sbjct: 188 NGLRRVLDELTLARADLEMQIENLKEELAYLKKNHEEEMNALRGQV-GGEINVEMDAAPG 246
Query: 264 TDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQ 323
D+S L E+R Q E +++N AE+WF + +L N E ++S K EI+E RR
Sbjct: 247 VDLSRILNEMRDQYEKMAEKNRKDAEDWFFSKTEELNREVATNSELVQSGKSEISELRRT 306
Query: 324 LQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLRE 383
+Q+ IEL+S K SLE L++ E R+ LS Q I +E +L + EM + +E
Sbjct: 307 MQALEIELQSQLSMKASLEGNLAETENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQE 366
Query: 384 YQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEA 443
Y+ LL+VK L+ EIA YR+LLEGE+ + + T R TI ++Q KV +
Sbjct: 367 YKILLDVKTRLEQEIATYRRLLEGEDAHLTQYKKEPV----TTRQVRTIVEEVQDGKVIS 422
Query: 444 PKLKV 448
+ +V
Sbjct: 423 SREQV 427
Score = 35.4 bits (80), Expect = 0.25
Identities = 73/330 (22%), Positives = 121/330 (36%), Gaps = 61/330 (18%)
Query: 331 LESVRGTKES---LERQLSDIEERHN----HDLSSYQDTIQQLENELRGTKWEMARHLRE 383
L+ VR +E+ LE ++ D +R D S Y TI++L+N++ + A L +
Sbjct: 99 LDKVRALEEANTELEVKIRDWYQRQAPGPARDYSQYYRTIEELQNKILTATVDNANILLQ 158
Query: 384 YQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISS-----KIQK 438
N ++A D +R E E+ + I G L +T++ +I+
Sbjct: 159 ID---NARLAAD----DFRTKFETEQALRLSVEADING-LRRVLDELTLARADLEMQIEN 210
Query: 439 PKVEAPKLKVQHKFVEEIIE-----ETKVE-----------------DEKSEMEEALTAI 476
K E LK H+ + E VE D+ +M E
Sbjct: 211 LKEELAYLKKNHEEEMNALRGQVGGEINVEMDAAPGVDLSRILNEMRDQYEKMAEKNRKD 270
Query: 477 TEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE 536
E+ S EE E ++ + E++ + ++A E++ + K EG E
Sbjct: 271 AEDWFFSKTEELNREVATNSELVQSGKSEISELRRTMQALEIELQSQLSMKASLEGNLAE 330
Query: 537 EEEDE-----------GAKSDQAEEGGSEKEGSSE--------KEEGEQEEGETEAEAEG 577
E G+ +Q + E E ++ K EQE EG
Sbjct: 331 TENRYCVQLSQIQGLIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEG 390
Query: 578 EEAEAKEEKKVEEKSEEVATKEELVADAKV 607
E+A + KK + +V T E V D KV
Sbjct: 391 EDAHLTQYKKEPVTTRQVRTIVEEVQDGKV 420
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 203 bits (516), Expect = 7e-52
Identities = 104/318 (32%), Positives = 194/318 (61%), Gaps = 2/318 (0%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQK--QASHAQLGDAYDQEIR 155
R+ E+EQ++ LN++FA +I+KV +LEQQNK ++ + L+++ + L ++Q I
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 156 ELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASL 215
LR L+ + E+ ++ + ++++ + LK ++E+E R E L+KD++ A +
Sbjct: 220 NLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYM 279
Query: 216 VKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRS 275
KVEL K +L DE+ FLR+ ++ E++ + I + + + + D+ + + E+++
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKA 339
Query: 276 QLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVR 335
Q E + ++ +AE W++ +Y +L A ++ + +R+ K+EIAE R +Q E++ V+
Sbjct: 340 QYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVK 399
Query: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALD 395
SL+ ++D E+R L ++ ++ LE+ L+ K ++AR L+EYQ+L+NVK+ALD
Sbjct: 400 KQCASLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALD 459
Query: 396 IEIAAYRKLLEGEETRFS 413
+EIA YRKLLEGEE R +
Sbjct: 460 VEIATYRKLLEGEECRLN 477
>gi|119395754 keratin 5 [Homo sapiens]
Length = 590
Score = 202 bits (515), Expect = 9e-52
Identities = 104/328 (31%), Positives = 197/328 (60%), Gaps = 5/328 (1%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQK--QASHAQLGDAYDQEIR 155
R+ E+EQ++ LN++FA +I+KV +LEQQNK ++ + L+++ + L ++Q I
Sbjct: 165 RTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 224
Query: 156 ELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASL 215
LR L+ + E+ ++ + ++++ + K ++E+E R E L+KD++ A +
Sbjct: 225 NLRRQLDSIVGERGRLDSELRNMQDLVEDFKNKYEDEINKRTTAENEFVMLKKDVDAAYM 284
Query: 216 VKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRS 275
KVEL+ KV +L DE+ F++ + E++ + + + + + + D+ + + E+++
Sbjct: 285 NKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVKA 344
Query: 276 QLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVR 335
Q E ++++ +AE W++ +Y +L + A ++ + +R+ K EI+E R +Q E+++V+
Sbjct: 345 QYEEIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRAEIDNVK 404
Query: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALD 395
+L+ ++D E+R L ++ + +LE L+ K +MAR LREYQ+L+N K+ALD
Sbjct: 405 KQCANLQNAIADAEQRGELALKDARNKLAELEEALQKAKQDMARLLREYQELMNTKLALD 464
Query: 396 IEIAAYRKLLEGEETRFSTFAGSITGPL 423
+EIA YRKLLEGEE R S G GP+
Sbjct: 465 VEIATYRKLLEGEECRLS---GEGVGPV 489
>gi|24430192 keratin 16 [Homo sapiens]
Length = 473
Score = 201 bits (511), Expect = 3e-51
Identities = 134/367 (36%), Positives = 197/367 (53%), Gaps = 10/367 (2%)
Query: 86 GGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQA-SHA 144
GG GGD L S EK +Q LNDR A Y++KV LE+ N ++E +I+ Q+Q S
Sbjct: 103 GGGFAGGDGLLVGS-EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEI 161
Query: 145 QLGDAYDQEIRELRATLEMVNHEKAQ--VQLDSDHLEEDIHRLKERFEEEARLRDDTEAA 202
+ Y + I +LR + E AQ +Q+D+ L D R K +E E LR EA
Sbjct: 162 KDYSPYFKTIEDLRNKIIAATIENAQPILQIDNARLAADDFRTK--YEHELALRQTVEAD 219
Query: 203 IRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYL 262
+ LR+ ++E +L + +L+ +++ L++E+A+LR NHEEE+ L Q + VE
Sbjct: 220 VNGLRRVLDELTLARTDLEMQIEGLKEELAYLRKNHEEEMLALRGQT-GGDVNVEMDAAP 278
Query: 263 KTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRR 322
D+S L E+R Q E +++N AE WF + +L + N E ++S++ E+ E RR
Sbjct: 279 GVDLSRILNEMRDQYEQMAEKNRRDAETWFLSKTEELNKEVASNSELVQSSRSEVTELRR 338
Query: 323 QLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLR 382
LQ IEL+S K SLE L + + R+ LS Q I +E +L + EM + +
Sbjct: 339 VLQGLEIELQSQLSMKASLENSLEETKGRYCMQLSQIQGLIGSVEEQLAQLRCEMEQQSQ 398
Query: 383 EYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVE 442
EYQ LL+VK L+ EIA YR+LLEGE+ S+ S G Y+ R T SS +
Sbjct: 399 EYQILLDVKTRLEQEIATYRRLLEGEDAHLSSQQAS--GQSYSSREVFT-SSSSSSSRQT 455
Query: 443 APKLKVQ 449
P LK Q
Sbjct: 456 RPILKEQ 462
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 201 bits (511), Expect = 3e-51
Identities = 103/318 (32%), Positives = 194/318 (61%), Gaps = 2/318 (0%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQK--QASHAQLGDAYDQEIR 155
R+ E+EQ++ LN++FA +I+KV +LEQQNK ++ + L+++ + L ++Q I
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 156 ELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASL 215
LR L+ + E+ ++ + ++++ + LK ++E+E R E L+KD++ A +
Sbjct: 220 NLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDAAYM 279
Query: 216 VKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRS 275
KVEL K +L DE+ FLR+ ++ E++ + I + + + + D+ + + E+++
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKA 339
Query: 276 QLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVR 335
Q E + ++ +AE W++ +Y +L A ++ + +R+ K+EIAE R +Q E++ V+
Sbjct: 340 QYEEIAQRSRAEAESWYQTKYEELQITAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVK 399
Query: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALD 395
+L+ ++D E+R L ++ ++ LE+ L+ K ++AR L+EYQ+L+NVK+ALD
Sbjct: 400 KQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALD 459
Query: 396 IEIAAYRKLLEGEETRFS 413
+EIA YRKLLEGEE R +
Sbjct: 460 VEIATYRKLLEGEECRLN 477
>gi|5031839 keratin 6A [Homo sapiens]
Length = 564
Score = 200 bits (509), Expect = 4e-51
Identities = 103/318 (32%), Positives = 192/318 (60%), Gaps = 2/318 (0%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQK--QASHAQLGDAYDQEIR 155
R+ E+EQ++ LN++FA +I+KV +LEQQNK +E + L+++ + L ++Q I
Sbjct: 160 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWTLLQEQGTKTVRQNLEPLFEQYIN 219
Query: 156 ELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASL 215
LR L+ + E+ ++ + +++ + K ++E+E R E L+KD++ A +
Sbjct: 220 NLRRQLDSIVGERGRLDSELRGMQDLVEDFKNKYEDEINKRTAAENEFVTLKKDVDAAYM 279
Query: 216 VKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRS 275
KVEL K +L DE+ FLR+ ++ E++ + I + + + + D+ + + E+++
Sbjct: 280 NKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSVVLSMDNNRNLDLDSIIAEVKA 339
Query: 276 QLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVR 335
Q E + ++ +AE W++ +Y +L A ++ + +R+ K+EIAE R +Q E++ V+
Sbjct: 340 QYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVK 399
Query: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALD 395
+L+ ++D E+R L ++ ++ LE+ L+ K ++AR L+EYQ+L+NVK+ALD
Sbjct: 400 KQCANLQAAIADAEQRGEMALKDAKNKLEGLEDALQKAKQDLARLLKEYQELMNVKLALD 459
Query: 396 IEIAAYRKLLEGEETRFS 413
+EIA YRKLLEGEE R +
Sbjct: 460 VEIATYRKLLEGEECRLN 477
>gi|195972866 keratin 10 [Homo sapiens]
Length = 584
Score = 200 bits (508), Expect = 6e-51
Identities = 125/329 (37%), Positives = 183/329 (55%), Gaps = 11/329 (3%)
Query: 87 GSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQL 146
G G GGD L NEK +Q LNDR A Y++KV LE+ N E+E +I+ +K + Q
Sbjct: 132 GGGFGGDGGLLSGNEKVTMQNLNDRLASYLDKVRALEESNYELEGKIKEWYEKHGNSHQ- 190
Query: 147 GDAYD-----QEIRELRATLEMVNHEKAQV--QLDSDHLEEDIHRLKERFEEEARLRDDT 199
G+ D + I +L+ + + + A + Q+D+ L D RLK +E E LR
Sbjct: 191 GEPRDYSKYYKTIDDLKNQILNLTTDNANILLQIDNARLAADDFRLK--YENEVALRQSV 248
Query: 200 EAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERK 259
EA I LR+ ++E +L K +L+ +++SL +E+A+L+ NHEEE+ DL + + VE
Sbjct: 249 EADINGLRRVLDELTLTKADLEMQIESLTEELAYLKKNHEEEMKDL-RNVSTGDVNVEMN 307
Query: 260 DYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAE 319
D++ L +RSQ E ++QN AE WF + +LT + N E I S K EI E
Sbjct: 308 AAPGVDLTQLLNNMRSQYEQLAEQNRKDAEAWFNEKSKELTTEIDNNIEQISSYKSEITE 367
Query: 320 YRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMAR 379
RR +Q+ IEL+S K+SLE L++ E R+ LS Q I LE +L+ + E
Sbjct: 368 LRRNVQALEIELQSQLALKQSLEASLAETEGRYCVQLSQIQAQISALEEQLQQIRAETEC 427
Query: 380 HLREYQDLLNVKMALDIEIAAYRKLLEGE 408
EYQ LL++K+ L+ EI YR LLEGE
Sbjct: 428 QNTEYQQLLDIKIRLENEIQTYRSLLEGE 456
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 199 bits (506), Expect = 1e-50
Identities = 107/318 (33%), Positives = 191/318 (60%), Gaps = 2/318 (0%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQA--SHAQLGDAYDQEIR 155
R+ E+EQ++ LN++FA +I+KV +LEQQNK +E + L+Q+ S L ++ +
Sbjct: 208 RTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLS 267
Query: 156 ELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASL 215
LR L+ + ++K ++Q + +++ + K ++EEE R E L+KD++ A L
Sbjct: 268 VLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYL 327
Query: 216 VKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRS 275
KVEL+ KV SL DE+ FL+ ++ E++ + + + + + + D+ + + E+R+
Sbjct: 328 NKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRA 387
Query: 276 QLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVR 335
Q E + ++ +AE ++ + +L + +Q+ + +++ K EIAE R +Q E+E+++
Sbjct: 388 QYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIK 447
Query: 336 GTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALD 395
++L+ ++D E+R + L +LE L+ K E+AR LREYQ+L++VK+ALD
Sbjct: 448 KQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALD 507
Query: 396 IEIAAYRKLLEGEETRFS 413
IEIA YRKLLEGEE R S
Sbjct: 508 IEIATYRKLLEGEEYRMS 525
>gi|15431316 keratin, hair, basic, 4 [Homo sapiens]
Length = 600
Score = 198 bits (504), Expect = 2e-50
Identities = 104/322 (32%), Positives = 192/322 (59%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ +EKEQ++ LN++FA +I+KV +LEQQNK +E + L++++ + L ++ I L
Sbjct: 162 KKDEKEQIKTLNNKFASFIDKVRFLEQQNKLLETKWSFLQEQKCIRSNLEPLFESYITNL 221
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R LE++ ++A++Q + +HL++ + K+++EEE R + E AL+KD++ A + K
Sbjct: 222 RRQLEVLVSDQARLQAERNHLQDVLEGFKKKYEEEVVCRANAENEFVALKKDVDAAFMNK 281
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V +L E+ FL++ + EE+ L + I + + V+ + ++ + E+++Q
Sbjct: 282 SDLEANVDTLTQEIDFLKTLYMEEIQLLQSHISETSVIVKMDNSRDLNLDGIIAEVKAQY 341
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
E + ++ AE W++ +Y ++ A Q+ + +R+ + EI E R +Q E+E +
Sbjct: 342 EEVARRSRADAEAWYQTKYEEMQVTAGQHCDNLRNIRNEINELTRLIQRLKAEIEHAKAQ 401
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
+ LE +++ E++ LS + + LE L+ K +MAR L EYQ+L+N K+ LDIE
Sbjct: 402 RAKLEAAVAEAEQQGEATLSDAKCKLADLECALQQAKQDMARQLCEYQELMNAKLGLDIE 461
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE+R G +
Sbjct: 462 IATYRRLLEGEESRLCEGVGPV 483
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 197 bits (501), Expect = 4e-50
Identities = 120/331 (36%), Positives = 186/331 (56%), Gaps = 5/331 (1%)
Query: 86 GGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQ 145
GG GGD L S EK +Q LNDR A Y++KV LE+ N ++E +I+ Q+Q A+
Sbjct: 101 GGGFAGGDGLLVGS-EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRP-AE 158
Query: 146 LGD--AYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAI 203
+ D Y + I +LR + + A V L D+ + ++E E LR EA I
Sbjct: 159 IKDYSPYFKTIEDLRNKILTATVDNANVLLQIDNARLAADDFRTKYETELNLRMSVEADI 218
Query: 204 RALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLK 263
LR+ ++E +L + +L+ +++SL++E+A+L+ NHEEE+ L Q+ + VE
Sbjct: 219 NGLRRVLDELTLARADLEMQIESLKEELAYLKKNHEEEMNALRGQV-GGDVNVEMDAAPG 277
Query: 264 TDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQ 323
D+S L E+R Q E +++N AEEWF + +L N E ++S K EI+E RR
Sbjct: 278 VDLSRILNEMRDQYEKMAEKNRKDAEEWFFTKTEELNREVATNSELVQSGKSEISELRRT 337
Query: 324 LQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLRE 383
+Q+ IEL+S K SLE L + + R+ L+ Q+ I +E +L + EM + +E
Sbjct: 338 MQNLEIELQSQLSMKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQE 397
Query: 384 YQDLLNVKMALDIEIAAYRKLLEGEETRFST 414
Y+ LL+VK L+ EIA YR+LLEGE+ S+
Sbjct: 398 YKILLDVKTRLEQEIATYRRLLEGEDAHLSS 428
>gi|239755818 PREDICTED: hypothetical protein isoform 2 [Homo
sapiens]
Length = 486
Score = 196 bits (498), Expect = 8e-50
Identities = 106/322 (32%), Positives = 185/322 (57%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ EKEQ++ LN RFA +I+KV +LEQQNK +E ++Q + ++ + L ++ I L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R E V + ++ + +H++E + K+++EEE LR E AL+KD++ A L K
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V++L E+ FLR +EEE+ L + I + + V+ + ++ + EI++Q
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ ++ +AE W++ + ++ ++ E +R KEEI E R +Q + E+E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
LE ++ E++ LS + + +LE L+ K +MA +REYQ+++N K+ LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R GS+
Sbjct: 403 IATYRRLLEGEEQRLCEGVGSV 424
>gi|239755816 PREDICTED: hypothetical protein isoform 1 [Homo
sapiens]
Length = 486
Score = 196 bits (498), Expect = 8e-50
Identities = 106/322 (32%), Positives = 185/322 (57%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ EKEQ++ LN RFA +I+KV +LEQQNK +E ++Q + ++ + L ++ I L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R E V + ++ + +H++E + K+++EEE LR E AL+KD++ A L K
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V++L E+ FLR +EEE+ L + I + + V+ + ++ + EI++Q
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ ++ +AE W++ + ++ ++ E +R KEEI E R +Q + E+E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
LE ++ E++ LS + + +LE L+ K +MA +REYQ+++N K+ LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R GS+
Sbjct: 403 IATYRRLLEGEEQRLCEGVGSV 424
>gi|239755814 PREDICTED: hypothetical protein isoform 3 [Homo
sapiens]
Length = 486
Score = 196 bits (498), Expect = 8e-50
Identities = 106/322 (32%), Positives = 185/322 (57%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ EKEQ++ LN RFA +I+KV +LEQQNK +E ++Q + ++ + L ++ I L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R E V + ++ + +H++E + K+++EEE LR E AL+KD++ A L K
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V++L E+ FLR +EEE+ L + I + + V+ + ++ + EI++Q
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ ++ +AE W++ + ++ ++ E +R KEEI E R +Q + E+E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
LE ++ E++ LS + + +LE L+ K +MA +REYQ+++N K+ LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R GS+
Sbjct: 403 IATYRRLLEGEEQRLCEGVGSV 424
>gi|27477127 keratin 82 [Homo sapiens]
Length = 513
Score = 196 bits (498), Expect = 8e-50
Identities = 105/322 (32%), Positives = 191/322 (59%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ +EKEQ++ LN+RFA +I KV +LEQ+NK +E + ++Q++ + ++ I L
Sbjct: 117 KRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRCCQTNIEPIFEGYISAL 176
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R L+ V+ ++ +++ + L+ + K+++EEE LR E AL+KD++ A L+K
Sbjct: 177 RRQLDCVSGDRVRLESELCSLQAALEGYKKKYEEELSLRPCVENEFVALKKDVDTAFLMK 236
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ ++L E+ FL+S +EEE+ L +QI + + V+ + + D+ + EI++Q
Sbjct: 237 ADLETNAEALVQEIDFLKSLYEEEICLLQSQISETSVIVKMDNSRELDVDGIIAEIKAQY 296
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ + ++ +AE W++CRY +L A + + +R+ K EI E + +Q E E+V+
Sbjct: 297 DDIASRSKAEAEAWYQCRYEELRVTAGNHCDNLRNRKNEILEMNKLIQRLQQETENVKAQ 356
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
+ LE +++ E++ L+ + + LE L+ K +MA L+EYQ+++N K+ LDIE
Sbjct: 357 RCKLEGAIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIE 416
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R G +
Sbjct: 417 IATYRRLLEGEEHRLCEGIGPV 438
>gi|14318422 keratin 86 [Homo sapiens]
Length = 486
Score = 196 bits (498), Expect = 8e-50
Identities = 106/322 (32%), Positives = 185/322 (57%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ EKEQ++ LN RFA +I+KV +LEQQNK +E ++Q + ++ + L ++ I L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R E V + ++ + +H++E + K+++EEE LR E AL+KD++ A L K
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V++L E+ FLR +EEE+ L + I + + V+ + ++ + EI++Q
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ ++ +AE W++ + ++ ++ E +R KEEI E R +Q + E+E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
LE ++ E++ LS + + +LE L+ K +MA +REYQ+++N K+ LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R GS+
Sbjct: 403 IATYRRLLEGEEQRLCEGVGSV 424
>gi|4504935 keratin 85 [Homo sapiens]
Length = 507
Score = 195 bits (496), Expect = 1e-49
Identities = 106/322 (32%), Positives = 186/322 (57%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ EKEQ++ LN RFA +I+KV +LEQQNK +E + Q + ++ + L + I L
Sbjct: 120 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKWQFYQNQRCCESNLEPLFSGYIETL 179
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R E V + ++ + +H++E + K+++EEE LR E L+KD++ A L K
Sbjct: 180 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVALRATAENEFVVLKKDVDCAYLRK 239
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V++L +E +FLR +EEE+ L A I + + V+ + ++ + EI++Q
Sbjct: 240 SDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDCIIAEIKAQY 299
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ + ++ +AE W++ + ++ ++ E +R KEEI E R +Q + E+E+ +
Sbjct: 300 DDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEIENAKCQ 359
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
+ LE +++ E++ LS + + +LE L+ K +MA L+EYQ+++N K+ LDIE
Sbjct: 360 RAKLEAAVAEAEQQGEAALSDARCKLAELEGALQKAKQDMACLLKEYQEVMNSKLGLDIE 419
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R GS+
Sbjct: 420 IATYRRLLEGEEHRLCEGVGSV 441
>gi|169790853 keratin, hair, basic, 1 [Homo sapiens]
Length = 505
Score = 194 bits (494), Expect = 2e-49
Identities = 105/322 (32%), Positives = 185/322 (57%)
Query: 98 RSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIREL 157
+ EKEQ++ LN RFA +I+KV +LEQQNK +E ++Q + ++ + L ++ I L
Sbjct: 103 KQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETL 162
Query: 158 RATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVK 217
R E V + ++ + +H++E + K+++EEE LR E AL+KD++ A L K
Sbjct: 163 RREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRK 222
Query: 218 VELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQL 277
+L+ V++L E+ FLR +EEE+ L + I + + V+ + ++ + EI++Q
Sbjct: 223 SDLEANVEALIQEIDFLRRLYEEEILILQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQY 282
Query: 278 ESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGT 337
+ ++ +AE W++ + ++ ++ E +R KEEI E R +Q + E+E+ +
Sbjct: 283 DDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQ 342
Query: 338 KESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIE 397
LE ++ E++ LS + + +LE L+ K +MA +REYQ+++N K+ LDIE
Sbjct: 343 NSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIE 402
Query: 398 IAAYRKLLEGEETRFSTFAGSI 419
IA YR+LLEGEE R G++
Sbjct: 403 IATYRRLLEGEEQRLCEGIGAV 424
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.298 0.120 0.305
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,316,953
Number of Sequences: 37866
Number of extensions: 2306952
Number of successful extensions: 103127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1641
Number of HSP's successfully gapped in prelim test: 2019
Number of HSP's that attempted gapping in prelim test: 13308
Number of HSP's gapped (non-prelim): 27479
length of query: 916
length of database: 18,247,518
effective HSP length: 111
effective length of query: 805
effective length of database: 14,044,392
effective search space: 11305735560
effective search space used: 11305735560
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.