Search of human proteins with 156564405

Search of human proteins with 156564405

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|156564405 catalytic phosphatidylinositol 3-kinase delta
[Homo sapiens]
         (1044 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo...  2127   0.0  
gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo sa...  1184   0.0  
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept...   743   0.0  
gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypept...   498   e-141
gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptid...   363   e-100
gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide...   357   2e-98
gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptid...   296   9e-80
gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapi...   180   5e-45
gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 ...   112   2e-24
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ...   112   2e-24
gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo sa...   100   9e-21
gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase...    75   4e-13
gi|13654237 protein kinase, DNA-activated, catalytic polypeptide...    73   2e-12
gi|4826730 FK506 binding protein 12-rapamycin associated protein...    64   1e-09
gi|126032350 protein kinase, DNA-activated, catalytic polypeptid...    61   5e-09
gi|113430845 PREDICTED: similar to protein kinase, DNA-activated...    61   5e-09
gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]     53   2e-06
gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]     53   2e-06
gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, pa...    53   2e-06
gi|157266317 ataxia telangiectasia and Rad3 related protein [Hom...    48   4e-05
gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad...    48   4e-05
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]            42   0.003
gi|38016202 SATB homeobox 2 [Homo sapiens]                             33   1.4  
gi|15559211 RE1-silencing transcription factor [Homo sapiens]          33   1.8  
gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]    33   1.8  
gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo sapi...    33   1.8  
gi|38569495 ELL associated factor 1 [Homo sapiens]                     33   1.8  
gi|46409514 hypothetical protein LOC400360 [Homo sapiens]              32   2.4  
gi|169213965 PREDICTED: similar to hCG1645909 [Homo sapiens]           31   5.3  
gi|239751822 PREDICTED: similar to hCG1645909 [Homo sapiens]           31   5.3  

>gi|156564405 catalytic phosphatidylinositol 3-kinase delta [Homo
            sapiens]
          Length = 1044

 Score = 2127 bits (5511), Expect = 0.0
 Identities = 1044/1044 (100%), Positives = 1044/1044 (100%)

Query: 1    MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH 60
            MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH
Sbjct: 1    MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH 60

Query: 61   MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL 120
            MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
Sbjct: 61   MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL 120

Query: 121  IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP 180
            IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP
Sbjct: 121  IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP 180

Query: 181  GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT 240
            GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
Sbjct: 181  GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT 240

Query: 241  LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR 300
            LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
Sbjct: 241  LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR 300

Query: 301  AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS 360
            AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
Sbjct: 301  AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS 360

Query: 361  SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW 420
            SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
Sbjct: 361  SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW 420

Query: 421  ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP 480
            ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP
Sbjct: 421  ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP 480

Query: 481  HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE 540
            HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE
Sbjct: 481  HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE 540

Query: 541  HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL 600
            HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
Sbjct: 541  HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL 600

Query: 601  RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV 660
            RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
Sbjct: 601  RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV 660

Query: 661  ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR 720
            ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR
Sbjct: 661  ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR 720

Query: 721  QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN 780
            QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN
Sbjct: 721  QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN 780

Query: 781  GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN 840
            GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN
Sbjct: 781  GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN 840

Query: 841  KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM 900
            KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
Sbjct: 841  KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM 900

Query: 901  IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC 960
            IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
Sbjct: 901  IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC 960

Query: 961  ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN 1020
            ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
Sbjct: 961  ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN 1020

Query: 1021 EALRESWKTKVNWLAHNVSKDNRQ 1044
            EALRESWKTKVNWLAHNVSKDNRQ
Sbjct: 1021 EALRESWKTKVNWLAHNVSKDNRQ 1044


>gi|5453894 catalytic phosphatidylinositol 3-kinase beta [Homo
            sapiens]
          Length = 1070

 Score = 1184 bits (3064), Expect = 0.0
 Identities = 607/1069 (56%), Positives = 780/1069 (72%), Gaps = 32/1069 (2%)

Query: 1    MPPGVDCPMEFWTKEE----NQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYE 56
            MPP +   ++ W  +     + S+ VDFLLPTG+Y+   V R A +S IKQ+LW +    
Sbjct: 7    MPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY 66

Query: 57   PLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQ 116
            P+F++L   ++Y+F C+NQTA  +ELEDE RRLCDV+PFLPVL+LV R  D  +KL +S+
Sbjct: 67   PMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKL-DSK 125

Query: 117  ISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQ 176
            I +LIGKGLHEFDSL DPEVN+FR KM +F EE       L W  WL+ ++P + EPS  
Sbjct: 126  IGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSI- 184

Query: 177  TWGPGTL--RLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVE 234
               P  L  +L    L+V V FE  ++ F+FQVS    P+ +   A++K+ T+  +    
Sbjct: 185  ---PENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEV 241

Query: 235  QPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQ--SNP 292
             P DY LQV+GR EY++G +PL QFQYI +C+ +   PH  +V    I  M +++  +  
Sbjct: 242  SPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIE 301

Query: 293  APQVQKPRAKPPPIPAKKPSSVS-LWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGN 351
            A   +     P P+P KK   +S +W    PF+I L++G+K+N +E +K+ V+AGLFHG 
Sbjct: 302  AAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGT 361

Query: 352  EMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTK--- 408
            E+LCKT+ SSEVS  ++ +W + LEFDINICDLPRMARLCFA+YAV++K K  +STK   
Sbjct: 362  ELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTIN 421

Query: 409  -------KKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRS 461
                   +K+ K   P+AW N M+FD+K QL+TG+  L+ W S PDE  E+LNP GTV++
Sbjct: 422  PSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQT 481

Query: 462  NPNTDSAAALLICLPEVAPHPVYYPALEKILELGRH---SECVHVTEEEQLQ----LREI 514
            NP T++A AL +  PE    P YYP  +KI+E       S+  +V+     +    L+EI
Sbjct: 482  NPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLPVLKEI 541

Query: 515  LERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPEL 574
            L+R    +L E+E DL+W LR + +E FP++L +LLL  KWNK EDVAQ+  LL  WP+L
Sbjct: 542  LDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKL 601

Query: 575  PVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLL 634
            P   ALELLDF++PD +V  +A+  LR+++D+EL QYLLQLVQVLKYE +LDC L++FLL
Sbjct: 602  PPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLL 661

Query: 635  DRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKA 694
            +RAL NR+IG FLFWHLRSE+H+P+V+++FG+ILEAYCRGS  HMKVL KQ EAL+KLK 
Sbjct: 662  ERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKT 721

Query: 695  LNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDS 754
            LN  +KL++ K  + + KE MH C++Q AY EALS LQSPL+P  +L+E+ VE+C +MDS
Sbjct: 722  LNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDS 781

Query: 755  KMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYG 814
            KMKPLW++Y+N+  G   SVG+IFKNGDDLRQDMLTLQM++LMD+LWK+ GLDLRM PYG
Sbjct: 782  KMKPLWLVYNNKVFGED-SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG 840

Query: 815  CLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEE 874
            CL TGDR+GLIEVV  S+TIA+IQLN SN+AA AAFNKDALLNWLK  N G+ LDRAIEE
Sbjct: 841  CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE 900

Query: 875  FTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFIL 934
            FTLSCAGYCVA+YVLGIGDRHSDNIM++++GQLFHIDFGH LGNFK+KFGI RERVPFIL
Sbjct: 901  FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL 960

Query: 935  TYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKD 994
            TYDF+HVIQQGKT N+EKF RFR  CE AY ILRRHG LF+ LFALM  AGLPEL+  KD
Sbjct: 961  TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD 1020

Query: 995  IQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNR 1043
            IQYLKDSLALGK+EEEALK F+ KF+EALRESW TKVNW+AH V KD R
Sbjct: 1021 IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYR 1069


>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
            [Homo sapiens]
          Length = 1068

 Score =  743 bits (1919), Expect = 0.0
 Identities = 430/1063 (40%), Positives = 616/1063 (57%), Gaps = 60/1063 (5%)

Query: 20   VVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQ 79
            ++V+ LLP G+ +     R A L TIK  L+  A+  PL  +L    +Y+F  + Q AE+
Sbjct: 20   ILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAER 79

Query: 80   QELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDF 139
            +E  DE RRLCD++ F P L+++   G+R +K++N +I   IG  + EFD + DPEV DF
Sbjct: 80   EEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDF 139

Query: 140  RAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVN----VK 195
            R  +   C+EA   R      +   Y +P  +E S +       +L    ++V     V 
Sbjct: 140  RRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVS 199

Query: 196  FEGSEESFTFQVSTKDVPLALMACALRKK-------ATVFRQPLVEQPEDYTLQVNGRHE 248
                ++ +T +++   VP  ++A A+RKK       +   +  ++E    Y L+V G  E
Sbjct: 200  PNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDE 259

Query: 249  YLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPA 308
            Y    YPL Q++YI SC+  G  P+L ++   S+ +         P   +  +   P   
Sbjct: 260  YFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMN 319

Query: 309  KKPSSVSLWSLEQPFRIELIQGSKVNADERM--KLVVQAGLFHGNEMLCKTVSSSEVSVC 366
             + S+ SLW +    RI+++  + VN + R   K+ V+ G++HG E LC  V++  V  C
Sbjct: 320  GETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVP-C 378

Query: 367  SEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLF 426
            S P W + L +DI I DLPR ARLC ++ +V          +K +K+  CP+AW N+ LF
Sbjct: 379  SNPRWNEWLNYDIYIPDLPRAARLCLSICSV--------KGRKGAKEEHCPLAWGNINLF 430

Query: 427  DYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYP 486
            DY D L +G+  L +WP VP    +LLNP G   SNPN ++    L    +     V +P
Sbjct: 431  DYTDTLVSGKMALNLWP-VPHGLEDLLNPIGVTGSNPNKETPCLELEF--DWFSSVVKFP 487

Query: 487  ALEKILE----------------------LGRHSECVHVTEEEQLQLREILERRGSGELY 524
             +  I E                      L R +E   + E ++ QL+ I  R    E+ 
Sbjct: 488  DMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNE---LRENDKEQLKAISTRDPLSEIT 544

Query: 525  EHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLD 584
            E EKD +W  RH      PE L +LLL  KWN  ++VAQM  L+  WP +    A+ELLD
Sbjct: 545  EQEKDFLWSHRHYCVT-IPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLD 603

Query: 585  FSFPDCHVGSFAIKSLRK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKI 643
             ++PD  V  FA++ L K LTDD+L QYL+QLVQVLKYE YLD  L +FLL +AL N++I
Sbjct: 604  CNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRI 663

Query: 644  GHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSS 703
            GHF FWHL+SEMH  +V+ RFGL+LE+YCR    ++K L +Q EA+ KL  L D +K   
Sbjct: 664  GHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEK 723

Query: 704  Q-KTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIM 762
            + +T K Q K L+   MR+  +++AL    SPL+P+  L  + +E+C  M S  +PLW+ 
Sbjct: 724  KDETQKVQMKFLVEQ-MRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLN 782

Query: 763  YSNEEAGSG---GSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTG 819
            + N +  S     +  IIFKNGDDLRQDMLTLQ+I++M+ +W+ +GLDLRM PYGCL  G
Sbjct: 783  WENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIG 842

Query: 820  DRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSC 879
            D  GLIEVV  S TI  IQ  K  +     FN   L  WLK KN GE  D AI+ FT SC
Sbjct: 843  DCVGLIEVVRNSHTIMQIQC-KGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSC 901

Query: 880  AGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFV 939
            AGYCVAT++LGIGDRH+ NIM+++ GQLFHIDFGHFL + K KFG  RERVPF+LT DF+
Sbjct: 902  AGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFL 961

Query: 940  HVIQQG--KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQY 997
             VI +G  +   + +FERF+  C +AY  +R+H  LF++LF++M  +G+PEL    DI Y
Sbjct: 962  IVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAY 1021

Query: 998  LKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040
            ++ +LAL KTE+EAL++F  + N+A    W TK++W+ H + +
Sbjct: 1022 IRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQ 1064


>gi|21237725 phosphoinositide-3-kinase, catalytic, gamma polypeptide
            [Homo sapiens]
          Length = 1102

 Score =  498 bits (1283), Expect = e-141
 Identities = 310/883 (35%), Positives = 476/883 (53%), Gaps = 61/883 (6%)

Query: 199  SEESFTFQVSTKDVPLALMAC---ALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYP 255
            S  S T +VS  D P A++      + KK ++   P  +  +D+ L+V GR EYL G  P
Sbjct: 227  STTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETP 286

Query: 256  LCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPI--------- 306
            +  FQ++  CL +G   H+ +             + P P + + R +  P+         
Sbjct: 287  IKNFQWVRHCLKNGEEIHVVL------------DTPPDPALDEVRKEEWPLVDDCTGVTG 334

Query: 307  ----------PAKKPSSVSLWSLEQPFRIELIQGSKVNADER---MKLVVQAGLFHGNEM 353
                        +   +VSLW  ++ FR++ I+G  +    R   + + V+A + HG ++
Sbjct: 335  YHEQLTIHGKDHESVFTVSLWDCDRKFRVK-IRGIDIPVLPRNTDLTVFVEANIQHGQQV 393

Query: 354  LCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYA----VIEKAKKARSTKK 409
            LC+  +S +     E +W   LEF I I DLP+ A L   +Y      +     A S   
Sbjct: 394  LCQRRTSPK-PFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSS 452

Query: 410  KSKKADCPIAWANLMLFDYKDQLKTGERCLYMW--PSVPDEKGELLNPTGTVRSNPNTDS 467
            +SK     + + NL+L D++  L+ GE  L+MW      +++G       T  +NP+ ++
Sbjct: 453  ESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKEN 512

Query: 468  AAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHE 527
            + ++ I L     HP+  P  +   +         +  + + QL  I+       L   +
Sbjct: 513  SMSISILLDNYC-HPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAED 571

Query: 528  KDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCS---WPE--LPVLSALEL 582
            K+L+W  R+E  +H P+A  +L    KW + E VA+   LL     W +  L V   ++L
Sbjct: 572  KELLWHFRYESLKH-PKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQL 630

Query: 583  LDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRK 642
            LD +F D +V + A++ L  L DD++  YLLQLVQ +K+E Y D  L +FLL R L N++
Sbjct: 631  LDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKR 690

Query: 643  IGHFLFWHLRSEM-HVPSVALRFGLILEAYCRG-STHHMKVLMKQGEALSKLKALNDFVK 700
            IGHFLFW LRSE+        RF +ILEAY RG  T  +    +Q + +  L+ +   +K
Sbjct: 691  IGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIK 750

Query: 701  LSSQKTPKPQTKELMHLCMRQEAYLEAL--SHLQSPLDPSTLLAEVCVEQCTFMDSKMKP 758
              S +     ++ +  L  + E    +      + P DP      + +E+C  M SK KP
Sbjct: 751  SLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKP 810

Query: 759  LWIMY--SNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCL 816
            LW+ +  ++  A S  ++GIIFK+GDDLRQDML LQ++++M+ +W+ E LDL + PYGC+
Sbjct: 811  LWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCI 870

Query: 817  PTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNP-GEALDRAIEEF 875
             TGD+ G+IE+V  + TIA IQ  +S +  T AF  + L +WLK K+P  E    A+E F
Sbjct: 871  STGDKIGMIEIVKDATTIAKIQ--QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERF 928

Query: 876  TLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILT 935
              SCAGYCVAT+VLGIGDRH+DNIMI E+G LFHIDFGH LGN+K+  GIN+ERVPF+LT
Sbjct: 929  VYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLT 988

Query: 936  YDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDI 995
             DF+ V+       S  F++F+  C +AY  LR H  L + LF++M   G+P+L+  +DI
Sbjct: 989  PDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDI 1048

Query: 996  QYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNV 1038
            +Y++D+L +GK EE+A K+F  +      + W  + NW  H V
Sbjct: 1049 EYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLV 1091


>gi|157671929 phosphoinositide-3-kinase, class 2 alpha polypeptide
            [Homo sapiens]
          Length = 1686

 Score =  363 bits (932), Expect = e-100
 Identities = 240/708 (33%), Positives = 372/708 (52%), Gaps = 25/708 (3%)

Query: 340  KLVVQAGLFHGNEMLCKTVSSSEVSVCSEPV----WKQRLEFDINICDLPRMARLCFALY 395
            K  +   L H  + L K + S +V           W + + F I I  LP  + L   L+
Sbjct: 706  KYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLF 765

Query: 396  AVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNP 455
             ++ ++  +     K +K    +   +L LFD+K  L  G + LY+W S         + 
Sbjct: 766  GILNQSSGSSPDSNKQRKGPEALGKVSLPLFDFKRFLTCGTKLLYLWTS-----SHTNSV 820

Query: 456  TGTVRSNPNTDSAAALLICLPEVAPHPVYY-PALEKILELGRHSECVHVTEEEQLQLREI 514
             GTV           L +  P  A   +Y  P +++ +    + E +    + + +L +I
Sbjct: 821  PGTVTKKGYVMERIVLQVDFPSPAFDIIYTTPQVDRSIIQQHNLETLE--NDIKGKLLDI 878

Query: 515  LERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPEL 574
            L +  S  L + +K  +W+ R+   +H P  L ++L      K  ++A+   LL  WP L
Sbjct: 879  LHKDSSLGLSKEDKAFLWEKRYYCFKH-PNCLPKILASAPNWKWVNLAKTYSLLHQWPAL 937

Query: 575  PVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLL 634
              L ALELLD  F D  V S A+  +  ++DDEL   L Q VQ LKYE YL+  L +FLL
Sbjct: 938  YPLIALELLDSKFADQEVRSLAVTWIEAISDDELTDLLPQFVQALKYEIYLNSSLVQFLL 997

Query: 635  DRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCR-GSTHHMKVLMKQGEALSKLK 693
             RAL N +I H L+W L+  +H    + R+  +L A    G     + L+KQ + +  L 
Sbjct: 998  SRALGNIQIAHNLYWLLKDALHDVQFSTRYEHVLGALLSVGGKRLREELLKQTKLVQLLG 1057

Query: 694  ALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMD 753
             + + V+ +S    +   +  M    R +++ +  +  + PL PS +  E+ ++ C+F  
Sbjct: 1058 GVAEKVRQASGSARQVVLQRSME---RVQSFFQK-NKCRLPLKPSLVAKELNIKSCSFFS 1113

Query: 754  SKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPY 813
            S   PL +   N +   G  + ++FK G+DLRQDML LQMI++MD +W +EGLDLRM  +
Sbjct: 1114 SNAVPLKVTMVNADP-MGEEINVMFKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIF 1172

Query: 814  GCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEA-LDRAI 872
             CL TG   G++E+V  SDT+  IQ+       T +F    L  WL+  NP E   ++A 
Sbjct: 1173 KCLSTGRDRGMVELVPASDTLRKIQVE---YGVTGSFKDKPLAEWLRKYNPSEEEYEKAS 1229

Query: 873  EEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPF 932
            E F  SCAG CVATYVLGI DRH+DNIM+R +G +FHIDFG FLG+ +      R+R PF
Sbjct: 1230 ENFIYSCAGCCVATYVLGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFKRDRAPF 1289

Query: 933  ILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCS 992
            +LT D  +VI  G+   + +F+ F   C +AY ++R+   LFL+L +LM  +GLPEL+  
Sbjct: 1290 VLTSDMAYVINGGE-KPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSI 1348

Query: 993  KDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040
            +D++Y++D+L    T+ EA   F  +  E+   S  TK N+  HN+++
Sbjct: 1349 QDLKYVRDALQPQTTDAEATIFF-TRLIESSLGSIATKFNFFIHNLAQ 1395


>gi|194097347 phosphoinositide-3-kinase, class 2 beta polypeptide
            [Homo sapiens]
          Length = 1634

 Score =  357 bits (917), Expect = 2e-98
 Identities = 288/991 (29%), Positives = 466/991 (47%), Gaps = 112/991 (11%)

Query: 114  NSQISLLIGKGL-HEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLE 172
            +S + LLI + L +  D L + +V DF  K C   EE    +  LG   ++QY     ++
Sbjct: 398  SSTVDLLIYQTLCYTHDDLRNVDVGDFVLKPCGL-EEFLQNKHALGSHEYIQYCRKFDID 456

Query: 173  PSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPL 232
               Q      +R     L   V  + S  +  + V  ++ P+         K T+ RQ L
Sbjct: 457  IRLQLMEQKVVRSD---LARTVNDDQSPSTLNYLVHLQERPV---------KQTISRQAL 504

Query: 233  VEQPEDYTLQVNGRHEYLY--GSYPLC------QFQYICSCLHSGLTPHLTMVHSSSILA 284
                + Y  +V+    +L   G +PL         + IC+ L +  TP +T   +     
Sbjct: 505  SLLFDTYHNEVDA---FLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALN----- 556

Query: 285  MRDEQSNPAPQVQKPRA-KPPPIPAKKPSSVSLWSLEQPFRIELIQ-------------- 329
                Q  P P   +P+  K P + A + +   +        ++L++              
Sbjct: 557  ----QLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAV 612

Query: 330  -GSK------------------VNADERMKLV---------VQAGLFHGNEMLCKTVSSS 361
             GS+                  V A  R+ ++         +   L HG + LC  + + 
Sbjct: 613  PGSRKHDLVQEACHFARSLAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTR 672

Query: 362  EVSVCSEP----VWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCP 417
                        VW Q++ F + +  LPR   LC  LYA+      + S   K ++    
Sbjct: 673  RAHFSKYLFHLIVWDQQICFPVQVNRLPRETLLCATLYALPIPPPGSSSEANKQRRVPEA 732

Query: 418  IAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRS-NPNTDSAAALLICLP 476
            + W    LF+++  L  G + L +WP+  +      NP+    + N +   +  L I  P
Sbjct: 733  LGWVTTPLFNFRQVLTCGRKLLGLWPATQE------NPSARWSAPNFHQPDSVILQIDFP 786

Query: 477  EVAPHPVYY-PALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLR 535
              A    +  P  +K        E   + EE+Q +L++I+++     L + +K  +W+ R
Sbjct: 787  TSAFDIKFTSPPGDKF---SPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLWEKR 843

Query: 536  HEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSF 595
            +            L     W +   +  +  LL  W  +    AL LL  +FPD  V   
Sbjct: 844  YYCHSEVSSLPLVLASAPSW-EWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRM 902

Query: 596  AIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEM 655
            A++ +  L+D EL  YL QLVQ LKYE YLD  L +FLL RA+++ ++ H+ FW L+  +
Sbjct: 903  AVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGL 962

Query: 656  HVPSVALRFGLILEAY--CRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQ-KTPKPQTK 712
                 ++R+  +L A   C G     K L ++      L  +N   KL+ Q +   P  +
Sbjct: 963  KDSQFSIRYQYLLAALLCCCG-----KGLREEFNRQCWL--VNALAKLAQQVREAAPSAR 1015

Query: 713  E-LMHLCMRQEAYLEALS-HLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGS 770
            + ++   + +     AL+   + PL PS L+  +    C++ +S   PL + + N +   
Sbjct: 1016 QGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLSFQNVDP-L 1074

Query: 771  GGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLR 830
            G ++ +IFK GDDLRQDMLTLQMI++M  +W QEGLD+RM  + C  TG   G++E++  
Sbjct: 1075 GENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPN 1134

Query: 831  SDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGE-ALDRAIEEFTLSCAGYCVATYVL 889
            ++T+  IQ+       T +F    L +WL+  NPGE   ++A+E F  SCAG CVATYVL
Sbjct: 1135 AETLRKIQVEHG---VTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYVL 1191

Query: 890  GIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNN 949
            GI DRH+DNIM++ +G +FHIDFG FLG+ +    I R+R PF+ T D  +VI  G    
Sbjct: 1192 GICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVI-NGGDKP 1250

Query: 950  SEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEE 1009
            S +F  F   C +AY ++R+H  LFL+L  LM + G+PELS  +D++Y+ D+L    TE 
Sbjct: 1251 SSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEA 1310

Query: 1010 EALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040
             A  +F  +  E+   S  TK+N+  HN+++
Sbjct: 1311 NATTYF-TRLIESSLGSVATKLNFFIHNLAQ 1340


>gi|194353959 phosphoinositide-3-kinase, class 2 gamma polypeptide
            [Homo sapiens]
          Length = 1445

 Score =  296 bits (757), Expect = 9e-80
 Identities = 215/675 (31%), Positives = 333/675 (49%), Gaps = 40/675 (5%)

Query: 371  WKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKD 430
            W  R+ F + I  LPR + L   L+ +      A             +AW  L LF  K+
Sbjct: 539  WVHRINFPLEIKSLPRESMLTVKLFGIACATNNANL-----------LAWTCLPLFP-KE 586

Query: 431  QLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEK 490
            +   G   L+      +   E++ P     S P   S   L I  P      +   + E 
Sbjct: 587  KSILGSM-LFSMTLQSEPPVEMITPGVWDVSQP---SPVTLQIDFPATGWEYMKPDSEEN 642

Query: 491  ILELGRH-SECV-HVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALAR 548
               L     EC+ H+    Q Q   +L         E +K  +W  R             
Sbjct: 643  RSNLEEPLKECIKHIARLSQKQTPLLLS--------EEKKRYLWFYRFYCNNENCSLPLV 694

Query: 549  LLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDEL 608
            L     W++   V++M  +L  W     L AL LL  SFPD  +   A++ L  L +DEL
Sbjct: 695  LGSAPGWDERT-VSEMHTILRRWTFSQPLEALGLLTSSFPDQEIRKVAVQQLDNLLNDEL 753

Query: 609  FQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLIL 668
             +YL QLVQ +K+E  L+  L + LL R+L + ++ H L+W L++  +       +  +L
Sbjct: 754  LEYLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLL 813

Query: 669  EA--YCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLE 726
             A  +C G   + +   +Q      +K L D  +     +   + + L     R E + +
Sbjct: 814  AALQFCAGKALNDEFSKEQ----KLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQ 869

Query: 727  ALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQ 786
             ++    PL+P+  +  +  + C++  S   PL I + N     G ++ IIFK GDDLRQ
Sbjct: 870  DVNTCHLPLNPALCIKGIDHDACSYFTSNALPLKITFINANP-MGKNISIIFKAGDDLRQ 928

Query: 787  DMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAA 846
            DML LQ+IQ+MD +W QEGLD++M  Y CL TG   GL+++V  + T+A I  +   +  
Sbjct: 929  DMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPDAVTLAKIHRHSGLIGP 988

Query: 847  TAAFNKDALLNWLKSKNPGEA-LDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESG 905
                 ++ +  W    N  +A  ++A+  F  SCAG+CV T++LG+ DRH+DNIM+ +SG
Sbjct: 989  ---LKENTIKKWFSQHNHLKADYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSG 1045

Query: 906  QLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYT 965
             +FHIDFG FLG+ +T  GI R+R PFI T +  + I +G   N + F+ F   C RAY 
Sbjct: 1046 HMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEG-GKNPQHFQDFVELCCRAYN 1104

Query: 966  ILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRE 1025
            I+R+H  L L+L  +M  AGLPELS  +D++Y+ ++L    T+ EA  HF  K  E+L E
Sbjct: 1105 IIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKESL-E 1163

Query: 1026 SWKTKVNWLAHNVSK 1040
             +  K+N L H +++
Sbjct: 1164 CFPVKLNNLIHTLAQ 1178


>gi|34761064 catalytic phosphatidylinositol 3-kinase 3 [Homo sapiens]
          Length = 887

 Score =  180 bits (457), Expect = 5e-45
 Identities = 121/421 (28%), Positives = 213/421 (50%), Gaps = 46/421 (10%)

Query: 625  LDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMK 684
            L+ +L  FL+ RA  N  + ++L+W++  E        R     E Y        + L+K
Sbjct: 471  LEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLK 530

Query: 685  QGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAY-------------------L 725
              +++  +++L     L++Q+T   +   LM    R+                      L
Sbjct: 531  GDKSVRVMRSL-----LAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNL 585

Query: 726  EALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLR 785
              +  +  PL+P   +  +  E  T   S + P  + +  E+   GG   +IFK+GDDLR
Sbjct: 586  SDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTED---GGKYPVIFKHGDDLR 642

Query: 786  QDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMA 845
            QD L LQ+I LMD L ++E LDL++TPY  L T  + G ++ + +S  +A +   + ++ 
Sbjct: 643  QDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFI-QSVPVAEVLDTEGSI- 700

Query: 846  ATAAFNKDALLNWLKSKN-PGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRES 904
                  ++    +  S+N P       ++ +  SCAGYCV TY+LG+GDRH DN+++ ++
Sbjct: 701  ------QNFFRKYAPSENGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKT 754

Query: 905  GQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAY 964
            G+LFHIDFG+ LG        + + +P  +  +   V   G T  SE+++ FR  C  A+
Sbjct: 755  GKLFHIDFGYILGR-------DPKPLPPPMKLNKEMVEGMGGT-QSEQYQEFRKQCYTAF 806

Query: 965  TILRRHGLLFLHLFALMRAAGLPELSCSKD--IQYLKDSLALGKTEEEALKHFRVKFNEA 1022
              LRR+  L L+LF+LM  A +P+++   D  ++ ++D   L  ++EEA+ + +   +E+
Sbjct: 807  LHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866

Query: 1023 L 1023
            +
Sbjct: 867  V 867



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 43/117 (36%), Positives = 65/117 (55%), Gaps = 1/117 (0%)

Query: 510 QLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLC 569
           QL  I+    + +L   E+DLVWK R+ +     +AL + L    W+  ++  Q L LL 
Sbjct: 295 QLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQ-EKALTKFLKCVNWDLPQEAKQALELLG 353

Query: 570 SWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLD 626
            W  + V  +LELL   + +  V  +A+  LR+  D++L  YLLQLVQ LKYE++ D
Sbjct: 354 KWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDD 410



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 40/189 (21%), Positives = 66/189 (34%), Gaps = 34/189 (17%)

Query: 341 LVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEK 400
           L V   +F   + L   V +S  +  +   W + L+  +   DLPR A++   ++ V   
Sbjct: 57  LYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGP 116

Query: 401 AKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVR 460
            K              P+    + LF      + G   L +WP+V  +  E     G   
Sbjct: 117 GKAV------------PVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTKTPGRTS 164

Query: 461 SNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREI-----L 515
           S  + D  +                  L K+ +  R    V V   ++L  REI      
Sbjct: 165 STLSEDQMS-----------------RLAKLTKAHRQGHMVKVDWLDRLTFREIEMINES 207

Query: 516 ERRGSGELY 524
           E+R S  +Y
Sbjct: 208 EKRSSNFMY 216


>gi|4505807 phosphatidylinositol 4-kinase type 3 alpha isoform 1 [Homo
            sapiens]
          Length = 854

 Score =  112 bits (279), Expect = 2e-24
 Identities = 123/506 (24%), Positives = 205/506 (40%), Gaps = 59/506 (11%)

Query: 543  PEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRK 602
            PEA+    LVT      D  ++ ++LC  P  P            P      + +K LR 
Sbjct: 339  PEAIK--FLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRS 396

Query: 603  LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVAL 662
               D +  Y+ Q+VQ L+Y+      + +++L  A  ++ + H   W++++ +++     
Sbjct: 397  FPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGH 454

Query: 663  R----FGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLC 718
            +     G +L+      T  +    K      +    N    +S+   P P+  E    C
Sbjct: 455  QKDPDIGDLLDQLVEEITGSLSGPAKDFYQ-REFDFFNKITNVSAIIKPYPKGDERKKAC 513

Query: 719  MRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMY--------------- 763
            +   + ++       P +P  ++ ++  +  T M S  K  ++                 
Sbjct: 514  LSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEG 573

Query: 764  ------SNEEAGSGGSVG-------IIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRM 810
                  S +E  +  + G        IFK GDD RQDML LQ+I L   +++  GLDL +
Sbjct: 574  LRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFV 633

Query: 811  TPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAA-----TAAFNKDALLNWLKSKNPG 865
             PY  + T    G+IE +   D  +  QL +          T  +  ++ L         
Sbjct: 634  FPYRVVATAPGCGVIECI--PDCTSRDQLGRQTDFGMYDYFTRQYGDESTL--------- 682

Query: 866  EALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGI 925
             A  +A   F  S A Y +  ++L I DRH+ NIM+ + G + HIDFG     F++  G 
Sbjct: 683  -AFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGG 738

Query: 926  NRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAG 985
            N    P I   D + +I  GK   +  F+ F   C R Y  +R +    + L  LM   G
Sbjct: 739  NLGWEPDIKLTDEMVMIMGGKM-EATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 797

Query: 986  LPELSCSKDIQYLKDSLALGKTEEEA 1011
            LP     + I+ LK   +   TE EA
Sbjct: 798  LPCFR-GQTIKLLKHRFSPNMTEREA 822


>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
            [Homo sapiens]
          Length = 2044

 Score =  112 bits (279), Expect = 2e-24
 Identities = 123/506 (24%), Positives = 205/506 (40%), Gaps = 59/506 (11%)

Query: 543  PEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRK 602
            PEA+    LVT      D  ++ ++LC  P  P            P      + +K LR 
Sbjct: 1529 PEAIK--FLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRS 1586

Query: 603  LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVAL 662
               D +  Y+ Q+VQ L+Y+      + +++L  A  ++ + H   W++++ +++     
Sbjct: 1587 FPPDAILFYIPQIVQALRYDKM--GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGH 1644

Query: 663  R----FGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLC 718
            +     G +L+      T  +    K      +    N    +S+   P P+  E    C
Sbjct: 1645 QKDPDIGDLLDQLVEEITGSLSGPAKDFYQ-REFDFFNKITNVSAIIKPYPKGDERKKAC 1703

Query: 719  MRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMY--------------- 763
            +   + ++       P +P  ++ ++  +  T M S  K  ++                 
Sbjct: 1704 LSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEG 1763

Query: 764  ------SNEEAGSGGSVG-------IIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRM 810
                  S +E  +  + G        IFK GDD RQDML LQ+I L   +++  GLDL +
Sbjct: 1764 LRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFV 1823

Query: 811  TPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAA-----TAAFNKDALLNWLKSKNPG 865
             PY  + T    G+IE +   D  +  QL +          T  +  ++ L         
Sbjct: 1824 FPYRVVATAPGCGVIECI--PDCTSRDQLGRQTDFGMYDYFTRQYGDESTL--------- 1872

Query: 866  EALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGI 925
             A  +A   F  S A Y +  ++L I DRH+ NIM+ + G + HIDFG     F++  G 
Sbjct: 1873 -AFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM---FESSPGG 1928

Query: 926  NRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAG 985
            N    P I   D + +I  GK   +  F+ F   C R Y  +R +    + L  LM   G
Sbjct: 1929 NLGWEPDIKLTDEMVMIMGGKM-EATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTG 1987

Query: 986  LPELSCSKDIQYLKDSLALGKTEEEA 1011
            LP     + I+ LK   +   TE EA
Sbjct: 1988 LPCFR-GQTIKLLKHRFSPNMTEREA 2012


>gi|4505809 catalytic phosphatidylinositol 4-kinase beta [Homo
            sapiens]
          Length = 828

 Score =  100 bits (248), Expect = 9e-21
 Identities = 69/238 (28%), Positives = 118/238 (49%), Gaps = 13/238 (5%)

Query: 774  VGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDT 833
            + +I K GDDLRQ++L  Q+++ +  +W+QE + L + PY  L     +G+IE V+ + +
Sbjct: 571  LSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVS 630

Query: 834  IANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGD 893
            I  ++  +S ++    F ++            EA   A   F  SCAGYC+  Y+L + D
Sbjct: 631  IHQVK-KQSQLSLLDYFLQE------HGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKD 683

Query: 894  RHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKF 953
            RH+ NI++   G + HIDFG  L +     G   E   F LT +FV V+      + + F
Sbjct: 684  RHNGNILLDAEGHIIHIDFGFILSSSPRNLGF--ETSAFKLTTEFVDVM---GGLDGDMF 738

Query: 954  ERFRGYCERAYTILRRHGLLFLHLFALM-RAAGLPELSCSKDIQYLKDSLALGKTEEE 1010
              ++    +     R+H    + +  +M + + LP    S  I+ LK+   +  TEE+
Sbjct: 739  NYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQ 796


>gi|239757646 PREDICTED: similar to phosphatidylinositol 4-kinase
           type 3 alpha [Homo sapiens]
          Length = 286

 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 50/142 (35%), Positives = 71/142 (50%), Gaps = 17/142 (11%)

Query: 777 IFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIAN 836
           IFK GDD RQDML LQ+I L   +++  GLDL + PY  + T    G+IE +   D  + 
Sbjct: 54  IFKLGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECI--PDCTSR 111

Query: 837 IQLNKSNMAA-----TAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGI 891
            QL +          T  +  ++ L          A  +A   F  S A Y +  ++L I
Sbjct: 112 DQLGRQTDFGMYDYFTRQYGDESTL----------AFQQARYNFIRSMAAYSLLLFLLQI 161

Query: 892 GDRHSDNIMIRESGQLFHIDFG 913
            DRH+ NIM+ + G + HIDFG
Sbjct: 162 KDRHNGNIMLDKKGHIIHIDFG 183


>gi|13654237 protein kinase, DNA-activated, catalytic polypeptide
            isoform 1 [Homo sapiens]
          Length = 4128

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 68/252 (26%), Positives = 107/252 (42%), Gaps = 60/252 (23%)

Query: 747  EQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGL 806
            E+ T M S  +P  I+    +         + K G+DLRQD    Q+ Q+M+ +  Q+  
Sbjct: 3724 ERVTVMASLRRPKRIIIRGHDEREHP---FLVKGGEDLRQDQRVEQLFQVMNGILAQDSA 3780

Query: 807  ----DLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALL------ 856
                 L++  Y  +P   R GLIE +  + T+ ++ LN  +    AA+  D         
Sbjct: 3781 CSQRALQLRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYK 3840

Query: 857  NWL-------------------------------KSKNPGEALDRAI------------- 872
            +WL                               +SK P + L RA              
Sbjct: 3841 DWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLAL 3900

Query: 873  -EEFTLSCAGYCVATYVLGIGDRHSDNIMI-RESGQLFHIDFGHFLGNFKTKFGINRERV 930
               F  S A  C++ ++LGIGDRH +N M+  E+G +  IDFGH  G+  T+F    E +
Sbjct: 3901 RSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGS-ATQFLPVPELM 3959

Query: 931  PFILTYDFVHVI 942
            PF LT  F++++
Sbjct: 3960 PFRLTRQFINLM 3971


>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
            [Homo sapiens]
          Length = 2549

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 74/261 (28%), Positives = 108/261 (41%), Gaps = 59/261 (22%)

Query: 754  SKMKP--LWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLR-- 809
            SK +P  L +M SN     G     + K  +DLRQD   +Q+  L++ L   +   LR  
Sbjct: 2165 SKQRPRKLTLMGSN-----GHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN 2219

Query: 810  --MTPYGCLPTGDRTGLIEVVLRSDTI--------------ANIQ--------------- 838
              +  Y  +P    +GLI  V   DT+               NI+               
Sbjct: 2220 LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT 2279

Query: 839  -LNKSNMAATAAFNKD----ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGD 893
             + K  +   A  N      A L WLKS +     DR    +T S A   +  Y+LG+GD
Sbjct: 2280 LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTN-YTRSLAVMSMVGYILGLGD 2338

Query: 894  RHSDNIMI-RESGQLFHIDFGHF--LGNFKTKFGINRERVPFILTYDFVHVIQ-QGKTNN 949
            RH  N+M+ R SG++ HIDFG    +   + KF    E++PF LT    + ++  G   N
Sbjct: 2339 RHPSNLMLDRLSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTRMLTNAMEVTGLDGN 2395

Query: 950  SEKFERFRGYCERAYTILRRH 970
                  +R  C     +LR H
Sbjct: 2396 ------YRITCHTVMEVLREH 2410


>gi|126032350 protein kinase, DNA-activated, catalytic polypeptide
            isoform 2 [Homo sapiens]
          Length = 4097

 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 60/222 (27%), Positives = 95/222 (42%), Gaps = 31/222 (13%)

Query: 747  EQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGL 806
            E+ T M S  +P  I+    +         + K G+DLRQD    Q+ Q+M+ +  Q+  
Sbjct: 3724 ERVTVMASLRRPKRIIIRGHDEREHP---FLVKGGEDLRQDQRVEQLFQVMNGILAQDSA 3780

Query: 807  ----DLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDA-------L 855
                 L++  Y  +P              D +  +   K ++ A     K A        
Sbjct: 3781 CSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMS-GKHDVGAYMLMYKGANRTETVTS 3839

Query: 856  LNWLKSKNPGEALDRAI--------------EEFTLSCAGYCVATYVLGIGDRHSDNIMI 901
                +SK P + L RA                 F  S A  C++ ++LGIGDRH +N M+
Sbjct: 3840 FRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV 3899

Query: 902  -RESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVI 942
              E+G +  IDFGH  G+  T+F    E +PF LT  F++++
Sbjct: 3900 AMETGGVIGIDFGHAFGS-ATQFLPVPELMPFRLTRQFINLM 3940


>gi|113430845 PREDICTED: similar to protein kinase, DNA-activated,
            catalytic polypeptide [Homo sapiens]
          Length = 4096

 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 60/222 (27%), Positives = 95/222 (42%), Gaps = 31/222 (13%)

Query: 747  EQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGL 806
            E+ T M S  +P  I+    +         + K G+DLRQD    Q+ Q+M+ +  Q+  
Sbjct: 3723 ERVTVMASLRRPKRIIIRGHDEREHP---FLVKGGEDLRQDQRVEQLFQVMNGILAQDSA 3779

Query: 807  ----DLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDA-------L 855
                 L++  Y  +P              D +  +   K ++ A     K A        
Sbjct: 3780 CSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMS-GKHDVGAYMLMYKGANRTETVTS 3838

Query: 856  LNWLKSKNPGEALDRAI--------------EEFTLSCAGYCVATYVLGIGDRHSDNIMI 901
                +SK P + L RA                 F  S A  C++ ++LGIGDRH +N M+
Sbjct: 3839 FRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMV 3898

Query: 902  -RESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVI 942
              E+G +  IDFGH  G+  T+F    E +PF LT  F++++
Sbjct: 3899 AMETGGVIGIDFGHAFGS-ATQFLPVPELMPFRLTRQFINLM 3939


>gi|20336199 ataxia telangiectasia mutated isoform 2 [Homo sapiens]
          Length = 1708

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 63/232 (27%), Positives = 94/232 (40%), Gaps = 47/232 (20%)

Query: 777  IFKNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTGLIEVVLRSD 832
            + K  DDLRQD +  Q+ Q+ + L ++        L +  Y  +P   R+G++E    + 
Sbjct: 1367 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 1426

Query: 833  TIANIQLNKSNMAAT-------AAFNKDALLNWLKSKNPGEA------------------ 867
             I    +N  + A         +AF     +  ++ K+  E                   
Sbjct: 1427 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 1486

Query: 868  -----LDRAIE-----EFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDFGHFL 916
                 LD AI       +T S A   +  Y+LG+GDRH  NI+I E S +L HID G  +
Sbjct: 1487 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 1544

Query: 917  GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
               + K     E VPF LT D V     G T     F R    CE+   ++R
Sbjct: 1545 AFEQGKILPTPETVPFRLTRDIVD--GMGITGVEGVFRR---CCEKTMEVMR 1591


>gi|71902540 ataxia telangiectasia mutated isoform 1 [Homo sapiens]
          Length = 3056

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 63/232 (27%), Positives = 94/232 (40%), Gaps = 47/232 (20%)

Query: 777  IFKNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTGLIEVVLRSD 832
            + K  DDLRQD +  Q+ Q+ + L ++        L +  Y  +P   R+G++E    + 
Sbjct: 2715 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2774

Query: 833  TIANIQLNKSNMAAT-------AAFNKDALLNWLKSKNPGEA------------------ 867
             I    +N  + A         +AF     +  ++ K+  E                   
Sbjct: 2775 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2834

Query: 868  -----LDRAIE-----EFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDFGHFL 916
                 LD AI       +T S A   +  Y+LG+GDRH  NI+I E S +L HID G  +
Sbjct: 2835 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 2892

Query: 917  GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
               + K     E VPF LT D V     G T     F R    CE+   ++R
Sbjct: 2893 AFEQGKILPTPETVPFRLTRDIVD--GMGITGVEGVFRR---CCEKTMEVMR 2939


>gi|169218268 PREDICTED: similar to Serine-protein kinase ATM, partial
            [Homo sapiens]
          Length = 2934

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 63/232 (27%), Positives = 94/232 (40%), Gaps = 47/232 (20%)

Query: 777  IFKNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTGLIEVVLRSD 832
            + K  DDLRQD +  Q+ Q+ + L ++        L +  Y  +P   R+G++E    + 
Sbjct: 2593 LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTV 2652

Query: 833  TIANIQLNKSNMAAT-------AAFNKDALLNWLKSKNPGEA------------------ 867
             I    +N  + A         +AF     +  ++ K+  E                   
Sbjct: 2653 PIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYF 2712

Query: 868  -----LDRAIE-----EFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDFGHFL 916
                 LD AI       +T S A   +  Y+LG+GDRH  NI+I E S +L HID G  +
Sbjct: 2713 CMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG--V 2770

Query: 917  GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
               + K     E VPF LT D V     G T     F R    CE+   ++R
Sbjct: 2771 AFEQGKILPTPETVPFRLTRDIVD--GMGITGVEGVFRR---CCEKTMEVMR 2817


>gi|157266317 ataxia telangiectasia and Rad3 related protein [Homo
            sapiens]
          Length = 2644

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 58/236 (24%), Positives = 102/236 (43%), Gaps = 43/236 (18%)

Query: 769  GSGGSVGIIF-KNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTG 823
            GS G   I+  K  DDLR+D   ++   L++   +++      +L +  Y  +P  D  G
Sbjct: 2316 GSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECG 2375

Query: 824  LIEVVLRSDTIANI---------------QLNKSNMAATAAFNKDALL--NWLKSKNPGE 866
            +IE V  +  +  I               +L +  +  +AA ++   +   +L  ++P  
Sbjct: 2376 IIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPI 2435

Query: 867  ALDRAIEEFT------LSCAGYCVAT-------YVLGIGDRHSDNIMIRE-SGQLFHIDF 912
              +  +  F        S + YC +T       Y+LG+GDRH +NI+    +G+  H+DF
Sbjct: 2436 FHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF 2495

Query: 913  GHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
                   +T F +  E VPF LT++ V+ +    T        FR  CE    ++R
Sbjct: 2496 NCLFNKGET-FEV-PEIVPFRLTHNMVNGMGPMGTEG-----LFRRACEVTMRLMR 2544


>gi|169165926 PREDICTED: similar to ataxia telangiectasia and Rad3
           related protein, partial [Homo sapiens]
          Length = 386

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 58/236 (24%), Positives = 102/236 (43%), Gaps = 43/236 (18%)

Query: 769 GSGGSVGIIF-KNGDDLRQDMLTLQMIQLMDVLWKQEG----LDLRMTPYGCLPTGDRTG 823
           GS G   I+  K  DDLR+D   ++   L++   +++      +L +  Y  +P  D  G
Sbjct: 58  GSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECG 117

Query: 824 LIEVVLRSDTIANI---------------QLNKSNMAATAAFNKDALL--NWLKSKNPGE 866
           +IE V  +  +  I               +L +  +  +AA ++   +   +L  ++P  
Sbjct: 118 IIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPI 177

Query: 867 ALDRAIEEFT------LSCAGYCVAT-------YVLGIGDRHSDNIMIRE-SGQLFHIDF 912
             +  +  F        S + YC +T       Y+LG+GDRH +NI+    +G+  H+DF
Sbjct: 178 FHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDF 237

Query: 913 GHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILR 968
                  +T F +  E VPF LT++ V+ +    T        FR  CE    ++R
Sbjct: 238 NCLFNKGET-FEV-PEIVPFRLTHNMVNGMGPMGTEG-----LFRRACEVTMRLMR 286


>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
          Length = 3661

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 9/113 (7%)

Query: 858  WLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMI-RESGQLFHIDFGHFL 916
            W     P E   R  + +  S A   +  Y++G+GDRH DN++I   +G++ HID+    
Sbjct: 2301 WSSCTTPDEWW-RVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCF 2359

Query: 917  GNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRR 969
               K K     E+VPF +T +    +  G T        FR  CE+   I+RR
Sbjct: 2360 E--KGKSLRVPEKVPFRMTQNIETAL--GVTGVEGV---FRLSCEQVLHIMRR 2405


>gi|38016202 SATB homeobox 2 [Homo sapiens]
          Length = 733

 Score = 33.1 bits (74), Expect = 1.4
 Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 7/61 (11%)

Query: 267 HSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIP-------AKKPSSVSLWSL 319
           HS    H+  +    +  +  +QS PA +   PR + PP P       AKKP S +  SL
Sbjct: 564 HSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRTKISL 623

Query: 320 E 320
           E
Sbjct: 624 E 624


>gi|15559211 RE1-silencing transcription factor [Homo sapiens]
          Length = 1097

 Score = 32.7 bits (73), Expect = 1.8
 Identities = 29/111 (26%), Positives = 56/111 (50%), Gaps = 8/111 (7%)

Query: 270 LTPHLTMVHSSSILAMRDEQSNPAPQVQK-PRAKPPPIPAKKPSSVSLWSLEQPFRIELI 328
           L+P + +V    +   + E S P   VQK P  + PP P + P  +   S + P R +  
Sbjct: 765 LSPPIEVVQKEPV---QMELSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLRKDKK 821

Query: 329 QGSKVNADERMK--LVVQAGLFHGNE--MLCKTVSSSEVSVCSEPVWKQRL 375
           + S + ++   K  ++++ GL    +  +L ++VS+ ++S  S P+ K+ L
Sbjct: 822 EKSNMQSERARKEQVLIEVGLVPVKDSWLLKESVSTEDLSPPSPPLPKENL 872


>gi|7382480 Rho GTPase activating protein 6 isoform 4 [Homo sapiens]
          Length = 771

 Score = 32.7 bits (73), Expect = 1.8
 Identities = 25/83 (30%), Positives = 33/83 (39%), Gaps = 8/83 (9%)

Query: 279 SSSILAMRDEQSNPAPQVQKPRAK-------PPPIPAK-KPSSVSLWSLEQPFRIELIQG 330
           S S L +   QS   PQ Q+P          PPP P   KP++ + W    P  +E    
Sbjct: 647 SESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTD 706

Query: 331 SKVNADERMKLVVQAGLFHGNEM 353
               A ER + V Q  L   N +
Sbjct: 707 QGGQAAEREQQVTQKKLSSANSL 729


>gi|95091875 Rho GTPase activating protein 6 isoform 1 [Homo
           sapiens]
          Length = 974

 Score = 32.7 bits (73), Expect = 1.8
 Identities = 25/83 (30%), Positives = 33/83 (39%), Gaps = 8/83 (9%)

Query: 279 SSSILAMRDEQSNPAPQVQKPRAK-------PPPIPAK-KPSSVSLWSLEQPFRIELIQG 330
           S S L +   QS   PQ Q+P          PPP P   KP++ + W    P  +E    
Sbjct: 850 SESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGPPEGVETPTD 909

Query: 331 SKVNADERMKLVVQAGLFHGNEM 353
               A ER + V Q  L   N +
Sbjct: 910 QGGQAAEREQQVTQKKLSSANSL 932


>gi|38569495 ELL associated factor 1 [Homo sapiens]
          Length = 268

 Score = 32.7 bits (73), Expect = 1.8
 Identities = 18/66 (27%), Positives = 29/66 (43%), Gaps = 1/66 (1%)

Query: 260 QYICSCLHSGLTPHLTMVHSSS-ILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWS 318
           +Y+   L S +    T    SS I A  ++Q    PQ  +P   PPP+P + P+   +  
Sbjct: 96  EYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPTRPPQTSQPPPPPPPMPFRAPTKPPVGP 155

Query: 319 LEQPFR 324
              P +
Sbjct: 156 KTSPLK 161


>gi|46409514 hypothetical protein LOC400360 [Homo sapiens]
          Length = 183

 Score = 32.3 bits (72), Expect = 2.4
 Identities = 28/109 (25%), Positives = 48/109 (44%), Gaps = 4/109 (3%)

Query: 647 LFWHLRSEMHVPSVALRFGLIL--EAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQ 704
           LF HLR+  H+  + LRF  I   E   R  T H   +++Q    +KL+    + ++ ++
Sbjct: 48  LFLHLRATHHMTELPLRFLYIALSEMTFREQTSHQ--IIQQMSLSNKLEQNQLYGEVINK 105

Query: 705 KTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMD 753
           +T  P     + L   Q+       ++ S     T+LA+ C  Q    D
Sbjct: 106 ETDNPVISSGLTLLFAQKPQSPGWKNMSSTKRVCTILADSCRAQAHAAD 154


>gi|169213965 PREDICTED: similar to hCG1645909 [Homo sapiens]
          Length = 591

 Score = 31.2 bits (69), Expect = 5.3
 Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 16/75 (21%)

Query: 359 SSSEVSVCSEPVWKQRLEFDINICDLPRMA-----------RLCFALYAVIEKAKKARST 407
           SSS     SEP+WKQR +   N    P  +           RL   L A  +KA K +  
Sbjct: 415 SSSSEDSDSEPLWKQREDMQANPVGTPGSSEEDEDTTWTPTRLASPLLAAEKKATKGQVA 474

Query: 408 K-----KKSKKADCP 417
           +     K+ KK  CP
Sbjct: 475 RAPVKPKEKKKGPCP 489


>gi|239751822 PREDICTED: similar to hCG1645909 [Homo sapiens]
          Length = 591

 Score = 31.2 bits (69), Expect = 5.3
 Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 16/75 (21%)

Query: 359 SSSEVSVCSEPVWKQRLEFDINICDLPRMA-----------RLCFALYAVIEKAKKARST 407
           SSS     SEP+WKQR +   N    P  +           RL   L A  +KA K +  
Sbjct: 415 SSSSEDSDSEPLWKQREDMQANPVGTPGSSEEDEDTTWTPTRLASPLLAAEKKATKGQVA 474

Query: 408 K-----KKSKKADCP 417
           +     K+ KK  CP
Sbjct: 475 RAPVKPKEKKKGPCP 489


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,614,576
Number of Sequences: 37866
Number of extensions: 1944689
Number of successful extensions: 6191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 6086
Number of HSP's gapped (non-prelim): 69
length of query: 1044
length of database: 18,247,518
effective HSP length: 112
effective length of query: 932
effective length of database: 14,006,526
effective search space: 13054082232
effective search space used: 13054082232
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.