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Search of human proteins with 109948304
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
(513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 1028 0.0
gi|16554629 WD repeat domain 5 [Homo sapiens] 145 1e-34
gi|16554627 WD repeat domain 5 [Homo sapiens] 145 1e-34
gi|23199987 WD repeat domain 5B [Homo sapiens] 138 1e-32
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 101 1e-21
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 101 1e-21
gi|26665869 WD repeat domain 51B [Homo sapiens] 100 2e-21
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 99 7e-21
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 99 7e-21
gi|32189425 WD repeat domain 69 [Homo sapiens] 98 2e-20
gi|13376840 WD repeat domain 61 [Homo sapiens] 98 2e-20
gi|157266266 WD repeat domain 86 [Homo sapiens] 93 5e-19
gi|19913369 transducin beta-like 3 [Homo sapiens] 93 5e-19
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 91 2e-18
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 90 4e-18
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 90 6e-18
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 89 1e-17
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 89 1e-17
gi|113865883 WD repeat domain 38 [Homo sapiens] 88 2e-17
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 87 3e-17
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 87 3e-17
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 87 3e-17
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 87 3e-17
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 86 8e-17
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 85 1e-16
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 85 1e-16
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 82 1e-15
gi|21071067 TBP-associated factor 5 [Homo sapiens] 79 8e-15
gi|148727341 serine/threonine kinase receptor associated protein... 79 8e-15
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 79 8e-15
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 1028 bits (2657), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVL 60
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVL
Sbjct: 1 MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVL 60
Query: 61 QAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENL 120
QAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENL
Sbjct: 61 QAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENL 120
Query: 121 LARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP 180
LARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP
Sbjct: 121 LARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPP 180
Query: 181 GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEV 240
GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEV
Sbjct: 181 GMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEV 240
Query: 241 WNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLR 300
WNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLR
Sbjct: 241 WNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLR 300
Query: 301 RFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD 360
RFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD
Sbjct: 301 RFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD 360
Query: 361 GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSN 420
GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSN
Sbjct: 361 GHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSN 420
Query: 421 TVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL 480
TVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL
Sbjct: 421 TVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL 480
Query: 481 TVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
TVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
Sbjct: 481 TVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP 513
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 145 bits (365), Expect = 1e-34
Identities = 90/317 (28%), Positives = 157/317 (49%), Gaps = 21/317 (6%)
Query: 202 PTQLSRHIKFGQKSH---VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 258
P + + +KF H V +FSP+G++L + S D I++W GK K +
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL- 88
Query: 259 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 318
+ + +S D+ +L + + D +K+W + SG+CL+ + HS V C +F+
Sbjct: 89 -------GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQ 140
Query: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
S+ I+S SFD+++RI +K+GK LK HS V+ F +DG I+S+S DG +IW+
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSS 437
+ +C T D S + N ++ + NT+ + + +G+ +++++
Sbjct: 201 ASGQCLKTL------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 438 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN 497
K E G+WI ED ++Y ++ T ++ + L H VI A HP +N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
Query: 498 LIAT--YSEDGLLKLWK 512
+IA+ D +KLWK
Sbjct: 315 IIASAALENDKTIKLWK 331
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 145 bits (365), Expect = 1e-34
Identities = 90/317 (28%), Positives = 157/317 (49%), Gaps = 21/317 (6%)
Query: 202 PTQLSRHIKFGQKSH---VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 258
P + + +KF H V +FSP+G++L + S D I++W GK K +
Sbjct: 30 PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKL- 88
Query: 259 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 318
+ + +S D+ +L + + D +K+W + SG+CL+ + HS V C +F+
Sbjct: 89 -------GISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFCCNFNPQ 140
Query: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
S+ I+S SFD+++RI +K+GK LK HS V+ F +DG I+S+S DG +IW+
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200
Query: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSS 437
+ +C T D S + N ++ + NT+ + + +G+ +++++
Sbjct: 201 ASGQCLKTL------IDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 438 GKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQN 497
K E G+WI ED ++Y ++ T ++ + L H VI A HP +N
Sbjct: 255 HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTEN 314
Query: 498 LIAT--YSEDGLLKLWK 512
+IA+ D +KLWK
Sbjct: 315 IIASAALENDKTIKLWK 331
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 138 bits (347), Expect = 1e-32
Identities = 90/303 (29%), Positives = 148/303 (48%), Gaps = 18/303 (5%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G V +FSP+G++L + S D I +W GK K L N + D A
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH---NLEISDVA----- 90
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
+S D+ L + + D +K+W ++SG+CL+ + HS V C +F+ S+ I+S SFD+T+
Sbjct: 91 WSSDSSRLVSASDDKTLKLWDVRSGKCLKTL-KGHSNYVFCCNFNPPSNLIISGSFDETV 149
Query: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLG 391
+I +K+GK LK HS V+ F G I+S S DG +IW+ + +C T
Sbjct: 150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL---- 205
Query: 392 STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNM-QGQIVRSFSSGKREGGDFVCCAL 450
D S + N ++ + NT+ + + +G+ +++++ K E
Sbjct: 206 --VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFS 263
Query: 451 SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIAT--YSEDGLL 508
G+WI ED ++Y ++ T ++ + L H VI A HP +NLIA+ D +
Sbjct: 264 VTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTI 323
Query: 509 KLW 511
KLW
Sbjct: 324 KLW 326
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 101 bits (252), Expect = 1e-21
Identities = 82/323 (25%), Positives = 133/323 (41%), Gaps = 40/323 (12%)
Query: 189 GKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKI 248
G K +E P ++ G +S V F P +V+ S D I+VW++ TG
Sbjct: 83 GPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDF 142
Query: 249 RKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSK 308
+ LK D+V + F ++LA+ + D IK+W Q +C+R H
Sbjct: 143 ERTLKGHT--------DSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMH-GHDH 193
Query: 309 GVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISAS 368
V+ ++ + I+SAS D+TI++ +++G +K F GH +V QDG I S S
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 369 SDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
+D TV++W + T EC + EH V C +
Sbjct: 254 NDQTVRVWVVATKECKAEL--------------------REHEHVVEC----------IS 283
Query: 429 GQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVI 488
S+SS G + P G ++ D + + TG TL H+ V
Sbjct: 284 WAPESSYSSISEATGSETKKSGKP-GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVR 342
Query: 489 GIAHHPHQNLIATYSEDGLLKLW 511
G+ H I + ++D L++W
Sbjct: 343 GVLFHSGGKFILSCADDKTLRVW 365
Score = 73.9 bits (180), Expect = 3e-13
Identities = 48/198 (24%), Positives = 88/198 (44%), Gaps = 29/198 (14%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G +V P+G ++V+ S D I++W TG K F + V +
Sbjct: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK--------TFTGHREWVRMVR 241
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ---------- 321
++D ++A+ + D ++VW + + +C R H V C+S++ +SS
Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAEL-REHEHVVECISWAPESSYSSISEATGSE 300
Query: 322 ----------ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDG 371
+LS S D+TI++ + +G L GH ++V F G +I+S + D
Sbjct: 301 TKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDK 360
Query: 372 TVKIWNMKTTECSNTFKS 389
T+++W+ K C T +
Sbjct: 361 TLRVWDYKNKRCMKTLNA 378
Score = 68.9 bits (167), Expect = 1e-11
Identities = 43/180 (23%), Positives = 79/180 (43%), Gaps = 13/180 (7%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK----------YQAQDNFM 261
G + V R + DG + + S D + VW T + + +L+ + + ++
Sbjct: 232 GHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYS 291
Query: 262 MMDDAVLCMC--FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
+ +A + L +G++D IK+W + +G CL H V + F
Sbjct: 292 SISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLV-GHDNWVRGVLFHSGG 350
Query: 320 SQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 379
ILS + D+T+R+ K+ + +K H FV F + Y+++ S D TVK+W +
Sbjct: 351 KFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 50.1 bits (118), Expect = 5e-06
Identities = 31/128 (24%), Positives = 62/128 (48%), Gaps = 9/128 (7%)
Query: 206 SRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDD 265
S + + + E + G +L++GS D I++W+ +TG L + D+
Sbjct: 288 SSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL--------VGHDN 339
Query: 266 AVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSA 325
V + F + + + A D ++VW ++ +C++ AH VT L F K + +++
Sbjct: 340 WVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTL-NAHEHFVTSLDFHKTAPYVVTG 398
Query: 326 SFDQTIRI 333
S DQT+++
Sbjct: 399 SVDQTVKV 406
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 101 bits (252), Expect = 1e-21
Identities = 65/197 (32%), Positives = 99/197 (50%), Gaps = 17/197 (8%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLC-M 270
G S VE R + + +V GS G I VW+ KI + L M A +C +
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL---------MGHKANICSL 111
Query: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
F E +A+G+QD IK+W I+ C+ R+ R HS+ V CL FS D + SA+ D T
Sbjct: 112 DFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHT 170
Query: 331 IRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSL 390
+++ L +GK + EF GH+ VN F + + + S SSD T++ W+++ F+ +
Sbjct: 171 VKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE------KFQVV 224
Query: 391 GSTAGTDITVNSVILLP 407
G V SV+ P
Sbjct: 225 SCIEGEPGPVRSVLFNP 241
Score = 69.3 bits (168), Expect = 8e-12
Identities = 47/234 (20%), Positives = 86/234 (36%), Gaps = 52/234 (22%)
Query: 278 MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLK 337
+LATG D ++ +W I C+ H+ V + + I++ S +IR+ L+
Sbjct: 35 LLATGGDDCRVNLWSINKPNCIMSLT-GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 338 SGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTD 397
+ K L+ GH + + F G ++ S S D +K+W+++ C ++
Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRG-------- 145
Query: 398 ITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWI 457
Q VR C SP G+W+
Sbjct: 146 ------------------------------HSQAVR-------------CLRFSPDGKWL 162
Query: 458 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
+D + + GK+ H V + HP++ L+A+ S D ++ W
Sbjct: 163 ASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
Score = 68.9 bits (167), Expect = 1e-11
Identities = 57/235 (24%), Positives = 106/235 (45%), Gaps = 24/235 (10%)
Query: 154 SVVPPSRLMALLG-----QALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRH 208
S+ P+ +M+L G ++++ + L+ G G V D+E K L
Sbjct: 49 SINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQ----SGSIRVWDLEAAKILRTL--- 101
Query: 209 IKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVL 268
G K+++ F P G+++ +GS D I++W+ RK ++ + + AV
Sbjct: 102 --MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR----RKGCVFRYRGH----SQAVR 151
Query: 269 CMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFD 328
C+ FS D + LA+ A D +K+W + +G+ + F H+ V + F + + S S D
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP-GHTGPVNVVEFHPNEYLLASGSSD 210
Query: 329 QTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
+TIR L+ + + G V F DG + S D +++++ + C
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 100 bits (250), Expect = 2e-21
Identities = 73/308 (23%), Positives = 129/308 (41%), Gaps = 19/308 (6%)
Query: 205 LSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD 264
L R+ K G K+ + SP+G+ L T S D F+ +WNF + ++
Sbjct: 10 LERYFK-GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKP--------HARAYRYVGHK 60
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
D V + FS +LA+ ++D +++W F +AH+ V + FS D + +
Sbjct: 61 DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEF-KAHTAPVRSVDFSADGQFLAT 119
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECS 384
AS D++I++ + + L H+ +V A F+ DG I+S S D T+KIW+ +C
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCV 179
Query: 385 NTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGD 444
N F +V + NP + + + + ++ + + G
Sbjct: 180 NNFSD---------SVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGG 230
Query: 445 FVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSE 504
C + P G ++ D L + G+L TL H V ++ L A+
Sbjct: 231 VNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGA 290
Query: 505 DGLLKLWK 512
D + LW+
Sbjct: 291 DTQVLLWR 298
Score = 87.4 bits (215), Expect = 3e-17
Identities = 59/214 (27%), Positives = 101/214 (47%), Gaps = 16/214 (7%)
Query: 199 EKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 258
++F L RH + V CA+FSPDG+ +V+ S D I++W+ TT K Q +
Sbjct: 134 QRFLYSLYRHTHW-----VRCAKFSPDGRLIVSCSEDKTIKIWD-TTNK-------QCVN 180
Query: 259 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 318
NF + F+ +A+ D +KVW ++ + L+ ++ HS GV C+SF
Sbjct: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQ-VHSGGVNCISFHPS 239
Query: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW-- 376
+ +++AS D T++I L G+ + +GH+ V +F++ G S +D V +W
Sbjct: 240 GNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRT 299
Query: 377 NMKTTECSNTFKSLGSTAGTDITVNSVILLPKNP 410
N C K D + + + P+ P
Sbjct: 300 NFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTP 333
Score = 31.6 bits (70), Expect = 1.8
Identities = 18/64 (28%), Positives = 28/64 (43%)
Query: 450 LSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLK 509
LSP G+ + D L ++ H+ V + PH NL+A+ S D ++
Sbjct: 26 LSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVR 85
Query: 510 LWKP 513
LW P
Sbjct: 86 LWIP 89
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 99.4 bits (246), Expect = 7e-21
Identities = 80/309 (25%), Positives = 134/309 (43%), Gaps = 21/309 (6%)
Query: 205 LSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD-NFMMM 263
L RH K G + V C FS + + L +GS+D + VW+ +K Q++ F
Sbjct: 11 LERHFK-GHRDAVTCVDFSINTKQLASGSMDSCLMVWH---------MKPQSRAYRFTGH 60
Query: 264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL 323
DAV C+ FS +LA+G++D +++W + + + RAH+ V + F D +
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 324 SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
+AS D+T+++ K L H ++V A F+ DG I+SAS D TVK+W+ + EC
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 384 SNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGG 443
+++ G V V P NTV + +++ R +
Sbjct: 180 VHSYCEHGG------FVTYVDFHPSG-TCIAAAGMDNTVKVWDVRTH--RLLQHYQLHSA 230
Query: 444 DFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYS 503
+ P G ++ D L + G+L TL H+ +A A+
Sbjct: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 504 EDGLLKLWK 512
D + +WK
Sbjct: 291 SDEQVMVWK 299
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 99.4 bits (246), Expect = 7e-21
Identities = 80/309 (25%), Positives = 134/309 (43%), Gaps = 21/309 (6%)
Query: 205 LSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD-NFMMM 263
L RH K G + V C FS + + L +GS+D + VW+ +K Q++ F
Sbjct: 11 LERHFK-GHRDAVTCVDFSINTKQLASGSMDSCLMVWH---------MKPQSRAYRFTGH 60
Query: 264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL 323
DAV C+ FS +LA+G++D +++W + + + RAH+ V + F D +
Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFV 119
Query: 324 SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
+AS D+T+++ K L H ++V A F+ DG I+SAS D TVK+W+ + EC
Sbjct: 120 TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 384 SNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGG 443
+++ G V V P NTV + +++ R +
Sbjct: 180 VHSYCEHGG------FVTYVDFHPSG-TCIAAAGMDNTVKVWDVRTH--RLLQHYQLHSA 230
Query: 444 DFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYS 503
+ P G ++ D L + G+L TL H+ +A A+
Sbjct: 231 AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGG 290
Query: 504 EDGLLKLWK 512
D + +WK
Sbjct: 291 SDEQVMVWK 299
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 97.8 bits (242), Expect = 2e-20
Identities = 69/298 (23%), Positives = 131/298 (43%), Gaps = 34/298 (11%)
Query: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
+P G + TGS D ++W+ TGK + + ++C+ F+ + ++ATG
Sbjct: 144 NPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE--------IVCLSFNPQSTLVATG 195
Query: 283 AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL 342
+ D K+W IQ+G+ + R HS + LSF+ +I++ SFD T+ + +G+ +
Sbjct: 196 SMDTTAKLWDIQNGEEVYTL-RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV 254
Query: 343 KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS 402
GH + ++ A+F D I++ S D T K+W+ +C T T D ++S
Sbjct: 255 NILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL-----TGHDDEILDS 309
Query: 403 VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR------EG--GDFVCCALSPRG 454
+ + ++ R FS+ R EG G+ + +P+G
Sbjct: 310 CF------------DYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQG 357
Query: 455 EWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
+ D + TG+ + L H ++ A + N++ T S+D ++W+
Sbjct: 358 NHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIWR 415
Score = 89.0 bits (219), Expect = 1e-17
Identities = 70/291 (24%), Positives = 127/291 (43%), Gaps = 27/291 (9%)
Query: 226 GQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT-EMLATGAQ 284
G +TGS D ++W+ +G+ L+ + V + F+ + +ATG+
Sbjct: 104 GSCFITGSYDRTCKLWDTASGEELNTLEGHR--------NVVYAIAFNNPYGDKIATGSF 155
Query: 285 DGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE 344
D K+W +++G+C F R H+ + CLSF+ S+ + + S D T ++ +++G+ +
Sbjct: 156 DKTCKLWSVETGKCYHTF-RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
Query: 345 FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAG-TDITVN-- 401
RGHS+ + +F G II+ S D TV +W+ T N +G A + + N
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNIL--IGHCAEISSASFNWD 272
Query: 402 -SVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCV 460
S+IL + + + +N + + G + + G+ I
Sbjct: 273 CSLILTGSMDKTCKLWDATNGKCVATLTG-----------HDDEILDSCFDYTGKLIATA 321
Query: 461 GEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
D FS T K L HE ++ I+ +P N + T S D ++W
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIW 372
Score = 64.3 bits (155), Expect = 3e-10
Identities = 50/209 (23%), Positives = 90/209 (43%), Gaps = 10/209 (4%)
Query: 304 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQD-GH 362
+AH +T ++ +K S ++ S+D+T ++ SG+ L GH + V F G
Sbjct: 89 KAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGD 148
Query: 363 YIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTV 422
I + S D T K+W+++T +C +TF+ G TA ++ L NP+ +V S
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFR--GHTA-------EIVCLSFNPQSTLVATGSMDT 199
Query: 423 VIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTV 482
Q + + + + + + G+ I D + + TG+ L
Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259
Query: 483 HEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
H ++ + + +LI T S D KLW
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLW 288
Score = 40.0 bits (92), Expect = 0.005
Identities = 19/81 (23%), Positives = 38/81 (46%), Gaps = 8/81 (9%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G + + F+P G +L+TGS D +W+ TG+ + L+ D +
Sbjct: 343 GHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHT--------DEIFSCA 394
Query: 272 FSRDTEMLATGAQDGKIKVWK 292
F+ ++ TG++D ++W+
Sbjct: 395 FNYKGNIVITGSKDNTCRIWR 415
Score = 31.6 bits (70), Expect = 1.8
Identities = 31/169 (18%), Positives = 62/169 (36%), Gaps = 8/169 (4%)
Query: 343 KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS 402
K + H + + G I+ S D T K+W+ + E NT + G V +
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE------GHRNVVYA 139
Query: 403 VILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGE 462
+ NP + S + + + + + + VC + +P+ +
Sbjct: 140 IAF--NNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSM 197
Query: 463 DFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
D + G+ TL H ++I ++ + + I T S D + +W
Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW 246
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 97.8 bits (242), Expect = 2e-20
Identities = 56/166 (33%), Positives = 92/166 (55%), Gaps = 9/166 (5%)
Query: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
FSPD QYL TG+ G + ++ +GK K+ + F +L + +S D + LA+
Sbjct: 114 FSPDSQYLATGTHVGKVNIFGVESGK--KEYSLDTRGKF------ILSIAYSPDGKYLAS 165
Query: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
GA DG I ++ I +G+ L E H+ + L+FS DS +++AS D I+I+ ++
Sbjct: 166 GAIDGIINIFDIATGKLLHTLE-GHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANL 224
Query: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTF 387
GH+S+V F D + +S+SSD +VK+W++ T C +TF
Sbjct: 225 AGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF 270
Score = 75.5 bits (184), Expect = 1e-13
Identities = 49/197 (24%), Positives = 94/197 (47%), Gaps = 16/197 (8%)
Query: 231 TGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKV 290
+ S+D I +W+ GK K + D + + FS D++ LATG GK+ +
Sbjct: 81 SSSLDAHIRLWDLENGKQIKSIDAGPVDAWTL--------AFSPDSQYLATGTHVGKVNI 132
Query: 291 WKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSS 350
+ ++SG+ + K + +++S D + S + D I I + +GK L GH+
Sbjct: 133 FGVESGKKEYSLD-TRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAM 191
Query: 351 FVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNP 410
+ TF+ D +++AS DG +KI++++ + G+ +G V +V P +
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLA------GTLSGHASWVLNVAFCP-DD 244
Query: 411 EHFVVCNRSNTVVIMNM 427
HFV + +V + ++
Sbjct: 245 THFVSSSSDKSVKVWDV 261
Score = 52.0 bits (123), Expect = 1e-06
Identities = 35/127 (27%), Positives = 56/127 (44%), Gaps = 9/127 (7%)
Query: 208 HIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAV 267
H G + FSPD Q LVT S DG+I++++ + L A V
Sbjct: 184 HTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHA--------SWV 235
Query: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
L + F D + + D +KVW + + C+ F H V + ++ + S+I+S
Sbjct: 236 LNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF-FDHQDQVWGVKYNGNGSKIVSVGD 294
Query: 328 DQTIRIH 334
DQ I I+
Sbjct: 295 DQEIHIY 301
Score = 50.8 bits (120), Expect = 3e-06
Identities = 52/253 (20%), Positives = 94/253 (37%), Gaps = 56/253 (22%)
Query: 264 DDAVLCMCFS----RDTEMLATGAQDGKIKVWKIQSGQC-LRRFERAHSKGVTCLSFSKD 318
DDA+ + + ++E + TG+ D +KVWK + + L+ H GV + S
Sbjct: 16 DDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHT 75
Query: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNM 378
S+S D IR+ L++GK +K G V W +
Sbjct: 76 LPIAASSSLDAHIRLWDLENGKQIKSIDA-----------------------GPVDAWTL 112
Query: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSG 438
+ S + GT + ++ + + + + R ++ +
Sbjct: 113 AFSPDSQYLAT-----GTHVGKVNIFGVESGKKEYSLDTRGKFILSI------------- 154
Query: 439 KREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNL 498
A SP G+++ D ++ F TGKL TL H + + P L
Sbjct: 155 ----------AYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQL 204
Query: 499 IATYSEDGLLKLW 511
+ T S+DG +K++
Sbjct: 205 LVTASDDGYIKIY 217
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 93.2 bits (230), Expect = 5e-19
Identities = 72/288 (25%), Positives = 130/288 (45%), Gaps = 44/288 (15%)
Query: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLK-YQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
SPDGQ L+TGS DG +W+ G+ L+ +++ F ++D C
Sbjct: 24 SPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTC---------- 73
Query: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
+ D I+ W + +GQCL+ + R H+ V + + ++Q+ S+S+D+T R+ + G+
Sbjct: 74 -SADCTIRRWDVLTGQCLQVY-RGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQM 129
Query: 342 LKEFRGHSSFVNEATFTQD--------------GHYIISASSDGTVKIWNMKTTECSNTF 387
+EFRGH + V ++ G +++ S+DGT K+W + + C T
Sbjct: 130 SREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTL 189
Query: 388 KSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIM--NMQGQIVRSFSSGKREGGDF 445
+ G T + L+ P H ++ + + G+ +R F + G
Sbjct: 190 R--GHTGAV------LCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVF---REHRGSV 238
Query: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHH 493
+C L R +Y D + C+ TG+ RT T H ++V + +H
Sbjct: 239 ICLELVNR--LVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYH 284
Score = 65.1 bits (157), Expect = 1e-10
Identities = 40/168 (23%), Positives = 74/168 (44%), Gaps = 15/168 (8%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G V C G TGS D I W+ +G+ + + + +C
Sbjct: 191 GHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLR----------VFREHRGSVIC 240
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
++ +G+ D +K W +G+C+R F AH + V+ L + + + + S D
Sbjct: 241 LELVNRLVYSGSADRTVKCWLADTGECVRTFT-AHRRNVSALKYH--AGTLFTGSGDACA 297
Query: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 379
R +SG+ + FRGH+ +N G + +AS DG +++W+++
Sbjct: 298 RAFDAQSGELRRVFRGHTFIIN--CIQVHGQVLYTASHDGALRLWDVR 343
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 4/98 (4%)
Query: 306 HSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ-DGHYI 364
H G+ LS S D ++L+ S D T R+ G+ +GH S+V TF Q +
Sbjct: 14 HRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV---TFCQLEDEAA 70
Query: 365 ISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNS 402
+ S+D T++ W++ T +C ++ S + N+
Sbjct: 71 FTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN 108
Score = 33.1 bits (74), Expect = 0.62
Identities = 12/45 (26%), Positives = 23/45 (51%)
Query: 339 GKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
G L+ H +N + + DG +++ S DGT ++W+ +C
Sbjct: 5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQC 49
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 93.2 bits (230), Expect = 5e-19
Identities = 55/175 (31%), Positives = 87/175 (49%), Gaps = 10/175 (5%)
Query: 219 CARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKD-------LKYQAQDNFMMMDDAVLCMC 271
C+R +LVTGS D +++W + K+ + QAQ D + +
Sbjct: 429 CSRLKES--FLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVA 486
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
+ + ++LATG+QD K+W + Q L F H +G+ C+ FS + +AS D TI
Sbjct: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRGLWCVQFSPMDQVLATASADGTI 545
Query: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
++ L+ LK F GH + V + F G ++S+ SDG VK+W +K EC T
Sbjct: 546 KLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRT 600
Score = 75.9 bits (185), Expect = 8e-14
Identities = 69/308 (22%), Positives = 128/308 (41%), Gaps = 37/308 (12%)
Query: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
SPD + LVT S + W + G + + K + V M F + +LATG
Sbjct: 75 SPDNEVLVTASRALLLAQWAWQEGSVTRLWK-------AIHTAPVATMAFDPTSTLLATG 127
Query: 283 AQDGKIKVWKIQSGQCLRRFERAHSKG----VTCLSFSKDSSQIL--SASFDQTIRIHGL 336
DG ++VW I +R + H +G V ++F D +++L S++ D IR+ L
Sbjct: 128 GCDGAVRVWDI-----VRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATDAAIRVWSL 182
Query: 337 KSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGT 396
+ L H S V F+ DGH ++S+ D IW++++ + + T S
Sbjct: 183 QDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFES---- 238
Query: 397 DITVNSVILLPKNPE----------HFVVCNRSNTVVIMN-MQGQIVRSFSSGKREGGDF 445
V + +LLP+ P +F+ T+ + GQ V + + G +
Sbjct: 239 ---VEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQEL 295
Query: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAH-HPHQNLIATYSE 504
C L+ + D L + + +L++ + ++V+ + P + + S
Sbjct: 296 THCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASN 355
Query: 505 DGLLKLWK 512
LK+++
Sbjct: 356 SPCLKVFE 363
Score = 62.0 bits (149), Expect = 1e-09
Identities = 46/177 (25%), Positives = 73/177 (41%), Gaps = 21/177 (11%)
Query: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTE--ML 279
F P L TG DG + VW+ +++ +F V + F D +L
Sbjct: 117 FDPTSTLLATGGCDGAVRVWDI--------VRHYGTHHFRGSPGVVHLVAFHPDPTRLLL 168
Query: 280 ATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSG 339
+ A D I+VW +Q CL AH VT L+FS D +LS+ D+ I L+S
Sbjct: 169 FSSATDAAIRVWSLQDRSCLAVL-TAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSC 227
Query: 340 KTLKEFRGHSSF----------VNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
+ + S V++ G Y ++A GT+++W + +C T
Sbjct: 228 QATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYT 284
Score = 61.2 bits (147), Expect = 2e-09
Identities = 39/160 (24%), Positives = 74/160 (46%), Gaps = 9/160 (5%)
Query: 217 VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT 276
+ +P+ + L TGS D ++W + Q F + C+ FS
Sbjct: 482 INSVAIAPNDKLLATGSQDRTAKLWALP--------QCQLLGVFSGHRRGLWCVQFSPMD 533
Query: 277 EMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL 336
++LAT + DG IK+W +Q CL+ FE H V ++F +Q+LS+ D +++ +
Sbjct: 534 QVLATASADGTIKLWALQDFSCLKTFE-GHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
Query: 337 KSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
K+ + ++ H V ++ + ++ +SD V +W
Sbjct: 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Score = 55.5 bits (132), Expect = 1e-07
Identities = 37/121 (30%), Positives = 61/121 (50%), Gaps = 11/121 (9%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G + + C +FSP Q L T S DG I++W + F D +VL +
Sbjct: 519 GHRRGLWCVQFSPMDQVLATASADGTIKLWALQ--------DFSCLKTFEGHDASVLKVA 570
Query: 272 F-SRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQT 330
F SR T++L++G+ DG +K+W I++ +C+R + AH V L S+ L+ + D
Sbjct: 571 FVSRGTQLLSSGS-DGLVKLWTIKNNECVRTLD-AHEDKVWGLHCSRLDDHALTGASDSR 628
Query: 331 I 331
+
Sbjct: 629 V 629
Score = 55.1 bits (131), Expect = 2e-07
Identities = 35/134 (26%), Positives = 64/134 (47%), Gaps = 15/134 (11%)
Query: 270 MCFSRDTE-MLATGAQDGKIKVWKI-----------QSGQCL---RRFERAHSKGVTCLS 314
+C SR E L TG+QD +K+W + +G L + +R H K + ++
Sbjct: 427 VCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVA 486
Query: 315 FSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 374
+ + + + S D+T ++ L + L F GH + F+ + +AS+DGT+K
Sbjct: 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIK 546
Query: 375 IWNMKTTECSNTFK 388
+W ++ C TF+
Sbjct: 547 LWALQDFSCLKTFE 560
Score = 48.1 bits (113), Expect = 2e-05
Identities = 66/366 (18%), Positives = 131/366 (35%), Gaps = 82/366 (22%)
Query: 215 SHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY--QAQDNFMMMDDAVLCMCF 272
S V FS DG +++ D +W+ + + + + + ++ ++ V +
Sbjct: 196 SAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGV 255
Query: 273 SRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKG--VTCLSFSKDSSQILSASFDQT 330
T G ++VW+ SGQC+ + G +T + + + +L+A+ D
Sbjct: 256 KSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHN 315
Query: 331 IRIHGLKSGKTLKEFRGHSSFVNEATFT--QDGHYIISASS------------------- 369
+ ++ +S + K+F G+S V + F +D H +++++S
Sbjct: 316 LLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGH 375
Query: 370 ---------------------DGTVKIWNMK-------------------TTECSNTFKS 389
D +V+IW M T CS +S
Sbjct: 376 TDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKES 435
Query: 390 LGSTAGTDITVN----SVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDF 445
T D TV LL KN N +++ Q ++ + D
Sbjct: 436 FLVTGSQDCTVKLWPLPKALLSKNTAP------DNGPILLQAQ-------TTQRCHDKDI 482
Query: 446 VCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSED 505
A++P + + +D ++ +L + H + + + P ++AT S D
Sbjct: 483 NSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASAD 542
Query: 506 GLLKLW 511
G +KLW
Sbjct: 543 GTIKLW 548
Score = 47.8 bits (112), Expect = 2e-05
Identities = 57/238 (23%), Positives = 103/238 (43%), Gaps = 20/238 (8%)
Query: 288 IKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL-KSGKTL--KE 344
+KV+++Q+ C + H+ V L + S + DQ++RI + K+G+ + +
Sbjct: 359 LKVFELQTSAC--QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQ 416
Query: 345 FRGHSSFVNEATFTQ-DGHYIISASSDGTVKIWNM-KTTECSNTFKSLGST---AGT--- 396
GH+ V ++ ++++ S D TVK+W + K NT G A T
Sbjct: 417 GSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQR 476
Query: 397 --DITVNSVILLPKNPEHFVVCNRSNTVVIMNM-QGQIVRSFSSGKREGGDFVCCALSPR 453
D +NSV + P N + ++ T + + Q Q++ FS G R G C SP
Sbjct: 477 CHDKDINSVAIAP-NDKLLATGSQDRTAKLWALPQCQLLGVFS-GHRRG--LWCVQFSPM 532
Query: 454 GEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
+ + D + ++ +T H+ V+ +A + + DGL+KLW
Sbjct: 533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 91.3 bits (225), Expect = 2e-18
Identities = 59/223 (26%), Positives = 107/223 (47%), Gaps = 19/223 (8%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G V S DGQ+ ++GS DG + +W+ TTG + +D VL +
Sbjct: 61 GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKD--------VLSVA 112
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ--ILSASFDQ 329
FS D + +G++D IK+W + +HS+ V+C+ FS +SS I+S +D+
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172
Query: 330 TIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKS 389
+++ L + K GH+ ++N T + DG S DG +W++ N K
Sbjct: 173 LVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDL------NEGKH 226
Query: 390 LGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIV 432
L + G DI +N++ P +++ ++ I +++G+I+
Sbjct: 227 LYTLDGGDI-INALCFSPN--RYWLCAATGPSIKIWDLEGKII 266
Score = 64.7 bits (156), Expect = 2e-10
Identities = 35/105 (33%), Positives = 56/105 (53%), Gaps = 4/105 (3%)
Query: 277 EMLATGAQDGKIKVWKIQSGQCL----RRFERAHSKGVTCLSFSKDSSQILSASFDQTIR 332
+M+ + ++D I +WK+ + +R R HS V+ + S D LS S+D T+R
Sbjct: 29 DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLR 88
Query: 333 IHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
+ L +G T + F GH+ V F+ D I+S S D T+K+WN
Sbjct: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Score = 58.5 bits (140), Expect = 1e-08
Identities = 59/222 (26%), Positives = 96/222 (43%), Gaps = 18/222 (8%)
Query: 299 LRRFERAHSKGVTCLSFSKD-SSQILSASFDQTIRIHGLKSGKT-----LKEFRGHSSFV 352
LR + H+ VT ++ + ILSAS D+TI + L +T + RGHS FV
Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFV 66
Query: 353 NEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEH 412
++ + DG + +S S DGT+++W++ T + F G V SV N
Sbjct: 67 SDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRF------VGHTKDVLSVAFSSDN-RQ 119
Query: 413 FVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCA-LSPRGE--WIYCVGEDFVLYCF 469
V +R T+ + N G V ++ ++V C SP I G D ++ +
Sbjct: 120 IVSGSRDKTIKLWNTLG--VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177
Query: 470 STVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
+ KL+ H + + P +L A+ +DG LW
Sbjct: 178 NLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219
Score = 29.3 bits (64), Expect = 9.0
Identities = 18/67 (26%), Positives = 26/67 (38%), Gaps = 5/67 (7%)
Query: 180 PGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIE 239
P + I GK V ++++E T + +S DGQ L G D +
Sbjct: 254 PSIKIWDLEGKIIVDELKQEVISTSSK-----AEPPQCTSLAWSADGQTLFAGYTDNLVR 308
Query: 240 VWNFTTG 246
VW T G
Sbjct: 309 VWQVTIG 315
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 90.1 bits (222), Expect = 4e-18
Identities = 54/162 (33%), Positives = 82/162 (50%), Gaps = 9/162 (5%)
Query: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
SP Y +GS D +W+F D Y + + D V C+ F ++ LATG
Sbjct: 393 SPYSLYFASGSHDRTARLWSF-------DRTYPLRIYAGHLAD-VDCVKFHPNSNYLATG 444
Query: 283 AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL 342
+ D +++W Q G +R F H V L+FS + + SA DQ +++ L SG
Sbjct: 445 STDKTVRLWSAQQGNSVRLFT-GHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY 503
Query: 343 KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECS 384
KE RGH+ + TF+ D I SAS D +V++W+++ T CS
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCS 545
Score = 79.0 bits (193), Expect = 1e-14
Identities = 80/348 (22%), Positives = 139/348 (39%), Gaps = 38/348 (10%)
Query: 173 QHQGLLPPGMTIDLFRGKAAVKDVEEE--------KFPTQLSRHIKFGQKSHVECARFSP 224
++ GL PP M + + +AA++ ++E T + + + + + A SP
Sbjct: 219 ENNGLEPPDMPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISP 278
Query: 225 DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQ 284
D + L G + I++W+ + K++ + + D + D E G +
Sbjct: 279 DSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILE----EEDDEDDNAGTE 334
Query: 285 DGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKE 344
+ R H V F DSS +LS S D +IR L S
Sbjct: 335 ---------------MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
Query: 345 FRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVI 404
++GH+ V + + Y S S D T ++W+ T + AG V+ V
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIY------AGHLADVDCVK 433
Query: 405 LLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGED 463
P N + + TV + + QG VR F+ + G + A SP G+++ GED
Sbjct: 434 FHP-NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHR---GPVLSLAFSPNGKYLASAGED 489
Query: 464 FVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
L + +G L + L H ++ + P LIA+ S D +++W
Sbjct: 490 QRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
Score = 72.8 bits (177), Expect = 7e-13
Identities = 39/127 (30%), Positives = 66/127 (51%), Gaps = 9/127 (7%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G + V+C +F P+ YL TGS D + +W+ G + F VL +
Sbjct: 424 GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG--------NSVRLFTGHRGPVLSLA 475
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
FS + + LA+ +D ++K+W + SG + R H+ +T L+FS DS I SAS D ++
Sbjct: 476 FSPNGKYLASAGEDQRLKLWDLASGTLYKEL-RGHTDNITSLTFSPDSGLIASASMDNSV 534
Query: 332 RIHGLKS 338
R+ +++
Sbjct: 535 RVWDIRN 541
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 89.7 bits (221), Expect = 6e-18
Identities = 69/294 (23%), Positives = 123/294 (41%), Gaps = 52/294 (17%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G V ++ DG L + S D + VW+ TG+ K LK +F+ C
Sbjct: 107 GHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLK--GHTSFVNS-----CYP 159
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
R +++ TG+ DG +K+W I+ ++ F+ + V ++F+ S QI+S D I
Sbjct: 160 ARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ--VLAVTFNDTSDQIISGGIDNDI 217
Query: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLG 391
++ L+ K RGH+ V + + +G Y++S + D TV++W+++
Sbjct: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP----------- 266
Query: 392 STAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALS 451
PK E V + N + N + ++R C+ S
Sbjct: 267 -------------FAPK--ERCVKIFQGN---VHNFEKNLLR--------------CSWS 294
Query: 452 PRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSED 505
P G I D +Y + T + ++ L H + +A HP + +I + S D
Sbjct: 295 PDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
Score = 65.1 bits (157), Expect = 1e-10
Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 15/167 (8%)
Query: 211 FGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
F V F+ +++G +D I+VW+ K+ ++ A D+V +
Sbjct: 190 FQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA--------DSVTGL 241
Query: 271 CFSRDTEMLATGAQDGKIKVWKIQ----SGQCLRRFE-RAHS--KGVTCLSFSKDSSQIL 323
S + L + A D ++VW ++ +C++ F+ H+ K + S+S D S+I
Sbjct: 242 SLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIA 301
Query: 324 SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSD 370
+ S D+ + + S + L + GH+ +NE F D IISASSD
Sbjct: 302 AGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 88.6 bits (218), Expect = 1e-17
Identities = 72/310 (23%), Positives = 129/310 (41%), Gaps = 20/310 (6%)
Query: 207 RHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQA-----QDNFM 261
R+ FG + V RFSPD + L + S DG +++W+ T+ RK + + +D
Sbjct: 736 RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQE 795
Query: 262 MMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 321
M+ V C +S D + A++ KI ++ I + L H + FS +
Sbjct: 796 DMEVIVKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 854
Query: 322 ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTT 381
+ A + + S + + RGH S+V+ F+ DG +++S D T+++W K
Sbjct: 855 AVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV 914
Query: 382 ECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKRE 441
C N+ L N V++L V + +I GQI
Sbjct: 915 -CKNSAVMLKQEVDVVFQENEVMVL-------AVDHIRRLQLINGRTGQI------DYLT 960
Query: 442 GGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIAT 501
CC LSP ++I E+ + V ++ ++ H+K V I + + +
Sbjct: 961 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1020
Query: 502 YSEDGLLKLW 511
S+D +++W
Sbjct: 1021 SSDDAEIQVW 1030
Score = 87.4 bits (215), Expect = 3e-17
Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 203 TQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMM 262
T LSR + V A FS DGQ + + D ++V+ TG+ ++K
Sbjct: 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH------- 656
Query: 263 MDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322
+D VLC FS D +AT + D K+K+W +G+ + ++ HS+ V C F+ S +
Sbjct: 657 -EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHHL 714
Query: 323 LSA--SFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
L A S D +++ L + GH++ VN F+ D + S S+DGT+K+W+
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 75.9 bits (185), Expect = 8e-14
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 3/124 (2%)
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
DAV CFS D + +A+ D ++V+K ++G+ L +AH V C +FS D I +
Sbjct: 616 DAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRFIAT 674
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISA--SSDGTVKIWNMKTTE 382
S D+ ++I +G+ + + HS VN FT H+++ A SSD +K+W++ E
Sbjct: 675 CSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 734
Query: 383 CSNT 386
C NT
Sbjct: 735 CRNT 738
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/172 (29%), Positives = 78/172 (45%), Gaps = 19/172 (11%)
Query: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
L++ S DG ++VWN TG KD F+ VL S D ++ + D
Sbjct: 1058 LLSWSFDGTVKVWNIITGNKEKD--------FVCHQGTVLSCDISHDATKFSSTSADKTA 1109
Query: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL------ 342
K+W L R H+ V C +FS DS+ + + + IRI + +G+ L
Sbjct: 1110 KIWSFDLLLPLHEL-RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPL 1168
Query: 343 --KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGS 392
+ H +V + F+ DG +ISA G +K WN+ T E S TF + G+
Sbjct: 1169 SEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGT 1218
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 15/175 (8%)
Query: 210 KFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGK--IRKDLKYQAQDNFMMMDDAV 267
+F K V +F+ D + L++ S D I+VWN+ K + + +D ++ + +
Sbjct: 999 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRL 1058
Query: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
L F DG +KVW I +G + F H V S D+++ S S
Sbjct: 1059 LSWSF------------DGTVKVWNIITGNKEKDFV-CHQGTVLSCDISHDATKFSSTSA 1105
Query: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
D+T +I L E RGH+ V + F+ D + + +G ++IWN+ E
Sbjct: 1106 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1160
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 304 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHY 363
R H+ V FS+D +I S D+T+++ ++G+ L E + H V F+ D +
Sbjct: 612 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 671
Query: 364 IISASSDGTVKIWNMKTTECSNTF 387
I + S D VKIWN T E +T+
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTY 695
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 187 FRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTG 246
F +A K + F L H G V C+ FS D L TG +G I +WN + G
Sbjct: 1100 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1159
Query: 247 KIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF 302
++ +++ V +CFS D +ML + G IK W + +G+ + F
Sbjct: 1160 ELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1213
Score = 37.7 bits (86), Expect = 0.025
Identities = 23/75 (30%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Query: 439 KREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDV--IGIAHHPHQ 496
K + +CCA S +I D + ++++TG+L T H + V + H
Sbjct: 654 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 713
Query: 497 NLIATYSEDGLLKLW 511
L+AT S D LKLW
Sbjct: 714 LLLATGSSDCFLKLW 728
Score = 33.5 bits (75), Expect = 0.48
Identities = 20/61 (32%), Positives = 27/61 (44%)
Query: 451 SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKL 510
S G+ I G D L F TG+ + HE +V+ A IAT S D +K+
Sbjct: 624 SEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 683
Query: 511 W 511
W
Sbjct: 684 W 684
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 88.6 bits (218), Expect = 1e-17
Identities = 72/310 (23%), Positives = 129/310 (41%), Gaps = 20/310 (6%)
Query: 207 RHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQA-----QDNFM 261
R+ FG + V RFSPD + L + S DG +++W+ T+ RK + + +D
Sbjct: 725 RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQE 784
Query: 262 MMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 321
M+ V C +S D + A++ KI ++ I + L H + FS +
Sbjct: 785 DMEVIVKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHL 843
Query: 322 ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTT 381
+ A + + S + + RGH S+V+ F+ DG +++S D T+++W K
Sbjct: 844 AVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV 903
Query: 382 ECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKRE 441
C N+ L N V++L V + +I GQI
Sbjct: 904 -CKNSAVMLKQEVDVVFQENEVMVL-------AVDHIRRLQLINGRTGQI------DYLT 949
Query: 442 GGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIAT 501
CC LSP ++I E+ + V ++ ++ H+K V I + + +
Sbjct: 950 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLIS 1009
Query: 502 YSEDGLLKLW 511
S+D +++W
Sbjct: 1010 SSDDAEIQVW 1019
Score = 87.4 bits (215), Expect = 3e-17
Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 203 TQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMM 262
T LSR + V A FS DGQ + + D ++V+ TG+ ++K
Sbjct: 593 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH------- 645
Query: 263 MDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322
+D VLC FS D +AT + D K+K+W +G+ + ++ HS+ V C F+ S +
Sbjct: 646 -EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHHL 703
Query: 323 LSA--SFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
L A S D +++ L + GH++ VN F+ D + S S+DGT+K+W+
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 75.9 bits (185), Expect = 8e-14
Identities = 42/124 (33%), Positives = 68/124 (54%), Gaps = 3/124 (2%)
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
DAV CFS D + +A+ D ++V+K ++G+ L +AH V C +FS D I +
Sbjct: 605 DAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRFIAT 663
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISA--SSDGTVKIWNMKTTE 382
S D+ ++I +G+ + + HS VN FT H+++ A SSD +K+W++ E
Sbjct: 664 CSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 723
Query: 383 CSNT 386
C NT
Sbjct: 724 CRNT 727
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/172 (29%), Positives = 78/172 (45%), Gaps = 19/172 (11%)
Query: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
L++ S DG ++VWN TG KD F+ VL S D ++ + D
Sbjct: 1047 LLSWSFDGTVKVWNIITGNKEKD--------FVCHQGTVLSCDISHDATKFSSTSADKTA 1098
Query: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL------ 342
K+W L R H+ V C +FS DS+ + + + IRI + +G+ L
Sbjct: 1099 KIWSFDLLLPLHEL-RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPL 1157
Query: 343 --KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGS 392
+ H +V + F+ DG +ISA G +K WN+ T E S TF + G+
Sbjct: 1158 SEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGT 1207
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 15/175 (8%)
Query: 210 KFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGK--IRKDLKYQAQDNFMMMDDAV 267
+F K V +F+ D + L++ S D I+VWN+ K + + +D ++ + +
Sbjct: 988 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRL 1047
Query: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
L F DG +KVW I +G + F H V S D+++ S S
Sbjct: 1048 LSWSF------------DGTVKVWNIITGNKEKDFV-CHQGTVLSCDISHDATKFSSTSA 1094
Query: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
D+T +I L E RGH+ V + F+ D + + +G ++IWN+ E
Sbjct: 1095 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1149
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 304 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHY 363
R H+ V FS+D +I S D+T+++ ++G+ L E + H V F+ D +
Sbjct: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 364 IISASSDGTVKIWNMKTTECSNTF 387
I + S D VKIWN T E +T+
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTY 684
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 187 FRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTG 246
F +A K + F L H G V C+ FS D L TG +G I +WN + G
Sbjct: 1089 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1148
Query: 247 KIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF 302
++ +++ V +CFS D +ML + G IK W + +G+ + F
Sbjct: 1149 ELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1202
Score = 37.7 bits (86), Expect = 0.025
Identities = 23/75 (30%), Positives = 35/75 (46%), Gaps = 2/75 (2%)
Query: 439 KREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDV--IGIAHHPHQ 496
K + +CCA S +I D + ++++TG+L T H + V + H
Sbjct: 643 KAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHH 702
Query: 497 NLIATYSEDGLLKLW 511
L+AT S D LKLW
Sbjct: 703 LLLATGSSDCFLKLW 717
Score = 33.5 bits (75), Expect = 0.48
Identities = 20/61 (32%), Positives = 27/61 (44%)
Query: 451 SPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKL 510
S G+ I G D L F TG+ + HE +V+ A IAT S D +K+
Sbjct: 613 SEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKI 672
Query: 511 W 511
W
Sbjct: 673 W 673
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 87.8 bits (216), Expect = 2e-17
Identities = 72/292 (24%), Positives = 133/292 (45%), Gaps = 30/292 (10%)
Query: 207 RHIKF-GQKS-HVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD 264
R +KF GQ V + FSPDGQ L+TGS DG + W +G++ L
Sbjct: 12 RRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHT-------- 63
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
V FS D + A+ + D +++W + +CLR + H + V +SFS DS Q+ S
Sbjct: 64 GPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL-KGHQRSVETVSFSPDSRQLAS 122
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECS 384
+D+ + + ++SG+ L+ GH + + F+ + + + S D TV IW+++ +
Sbjct: 123 GGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPA 182
Query: 385 NTFKSL-GSTAGTD---ITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKR 440
+ ++L G +A + + ++ + + + + +++ ++G + S
Sbjct: 183 VSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS---- 238
Query: 441 EGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAH 492
A SP W+ G ++ + TGK TL K V+ +AH
Sbjct: 239 -------IAFSPDELWLASAGYSRMVKVWDCNTGKCLETL----KGVLDVAH 279
Score = 80.9 bits (198), Expect = 3e-15
Identities = 55/191 (28%), Positives = 90/191 (47%), Gaps = 19/191 (9%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G + VE FSPD + L +G D + +W+ +G++ + L +D+ D
Sbjct: 103 GHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLR-LLVGHRDSIQSSD------- 154
Query: 272 FSRDTEMLATGAQDGKIKVWKIQ------SGQCLRRFERAHSKGVTCLSFSKDSSQILSA 325
FS LATG+ D + +W ++ S Q L HS ++CL +S S + S
Sbjct: 155 FSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE----GHSANISCLCYSA-SGLLASG 209
Query: 326 SFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSN 385
S+D+TI I + L + +GH ++V F+ D ++ SA VK+W+ T +C
Sbjct: 210 SWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
Query: 386 TFKSLGSTAGT 396
T K + A T
Sbjct: 270 TLKGVLDVAHT 280
Score = 70.5 bits (171), Expect = 4e-12
Identities = 41/161 (25%), Positives = 79/161 (49%), Gaps = 7/161 (4%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMC 271
G + ++ + FSP L TGS D + +W+ + + +QA + + C+C
Sbjct: 145 GHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM--VTPAVSHQALEGHSAN---ISCLC 199
Query: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
+S + +LA+G+ D I +WK + L + + H V ++FS D + SA + + +
Sbjct: 200 YSA-SGLLASGSWDKTIHIWKPTTSSLLIQL-KGHVTWVKSIAFSPDELWLASAGYSRMV 257
Query: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGT 372
++ +GK L+ +G + FT DG ++S ++D T
Sbjct: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298
Score = 33.5 bits (75), Expect = 0.48
Identities = 22/72 (30%), Positives = 34/72 (47%)
Query: 440 REGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLI 499
+ GG+ A SP G+ + ED +Y + T +G+L L H V P +L
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 500 ATYSEDGLLKLW 511
A+ S D ++LW
Sbjct: 79 ASASCDCTVRLW 90
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 87.4 bits (215), Expect = 3e-17
Identities = 71/284 (25%), Positives = 128/284 (45%), Gaps = 37/284 (13%)
Query: 264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSK-GVTCLSFSKDSSQI 322
D V + FS + +LATG D ++K+W++ +C + + S G+T + F S +
Sbjct: 322 DGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYL 381
Query: 323 LSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
L+AS D RI + + GHS V A F D I+S S D T+K+W++++
Sbjct: 382 LAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKV 441
Query: 383 CSNTFKSLGSTAGT--------------------DITVNSVI----------LLPKNPEH 412
C T + GS+ DI S++ L NPE
Sbjct: 442 CIKTVFA-GSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPER 500
Query: 413 --FVVCNRSNTVVIMNMQGQIVR-SFSS-GKREGGDFVCCALSPRGEWIYCVGEDFVLYC 468
+ C+R + + +++++ ++ +FS+ G + G D+ SP G ++ + LY
Sbjct: 501 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYI 560
Query: 469 FSTVTGKLERTLT-VHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
+S +TGK+E+ L+ H + +A P + + + + LW
Sbjct: 561 WSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 604
Score = 58.5 bits (140), Expect = 1e-08
Identities = 73/320 (22%), Positives = 132/320 (41%), Gaps = 49/320 (15%)
Query: 135 GSSKEKRRAAIA----QALAGEVSVV---PPSRLMALLGQALK---WQ------QHQGLL 178
GS KE R A A A GEV+ V P SRL+A G + W+ + +G L
Sbjct: 303 GSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSL 362
Query: 179 P---PGMTIDLFRGKAAVKDVEEEKFPTQL-------SRHIKFGQKSHVECARFSPDGQY 228
G+T F + F +++ RH G V A+F D
Sbjct: 363 SGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNAR 422
Query: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
+V+GS D +++W+ + K + + N ++ + + + +G D KI
Sbjct: 423 IVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE-----------QCVMSGHFDKKI 471
Query: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGH 348
+ W I+S +R E +T L + + +++LS S D +++ L++ + F
Sbjct: 472 RFWDIRSESIVREMELLGK--ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAP 529
Query: 349 ----SSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVI 404
S F+ DG Y+ + S++G++ IW++ T + S+ ++N+V
Sbjct: 530 GFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS-----SINAVA 584
Query: 405 LLPKNPEHFVVCNRSNTVVI 424
P H V ++ V+
Sbjct: 585 WSPSG-SHVVSVDKGCKAVL 603
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 87.4 bits (215), Expect = 3e-17
Identities = 71/284 (25%), Positives = 128/284 (45%), Gaps = 37/284 (13%)
Query: 264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSK-GVTCLSFSKDSSQI 322
D V + FS + +LATG D ++K+W++ +C + + S G+T + F S +
Sbjct: 303 DGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYL 362
Query: 323 LSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
L+AS D RI + + GHS V A F D I+S S D T+K+W++++
Sbjct: 363 LAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKV 422
Query: 383 CSNTFKSLGSTAGT--------------------DITVNSVI----------LLPKNPEH 412
C T + GS+ DI S++ L NPE
Sbjct: 423 CIKTVFA-GSSCNDIVCTEQCVMSGHFDKKIRFWDIRSESIVREMELLGKITALDLNPER 481
Query: 413 --FVVCNRSNTVVIMNMQGQIVR-SFSS-GKREGGDFVCCALSPRGEWIYCVGEDFVLYC 468
+ C+R + + +++++ ++ +FS+ G + G D+ SP G ++ + LY
Sbjct: 482 TELLSCSRDDLLKVIDLRTNAIKQTFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYI 541
Query: 469 FSTVTGKLERTLT-VHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
+S +TGK+E+ L+ H + +A P + + + + LW
Sbjct: 542 WSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKAVLW 585
Score = 58.5 bits (140), Expect = 1e-08
Identities = 73/320 (22%), Positives = 132/320 (41%), Gaps = 49/320 (15%)
Query: 135 GSSKEKRRAAIA----QALAGEVSVV---PPSRLMALLGQALK---WQ------QHQGLL 178
GS KE R A A A GEV+ V P SRL+A G + W+ + +G L
Sbjct: 284 GSGKEVRVPATALCVFDAHDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFGEKCEFKGSL 343
Query: 179 P---PGMTIDLFRGKAAVKDVEEEKFPTQL-------SRHIKFGQKSHVECARFSPDGQY 228
G+T F + F +++ RH G V A+F D
Sbjct: 344 SGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNAR 403
Query: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
+V+GS D +++W+ + K + + N ++ + + + +G D KI
Sbjct: 404 IVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTE-----------QCVMSGHFDKKI 452
Query: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGH 348
+ W I+S +R E +T L + + +++LS S D +++ L++ + F
Sbjct: 453 RFWDIRSESIVREMELLGK--ITALDLNPERTELLSCSRDDLLKVIDLRTNAIKQTFSAP 510
Query: 349 ----SSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVI 404
S F+ DG Y+ + S++G++ IW++ T + S+ ++N+V
Sbjct: 511 GFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSS-----SINAVA 565
Query: 405 LLPKNPEHFVVCNRSNTVVI 424
P H V ++ V+
Sbjct: 566 WSPSG-SHVVSVDKGCKAVL 584
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 87.4 bits (215), Expect = 3e-17
Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 203 TQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMM 262
T LSR + V A FS DGQ + + D ++V+ TG+ ++K
Sbjct: 604 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH------- 656
Query: 263 MDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322
+D VLC FS D +AT + D K+K+W +G+ + ++ HS+ V C F+ S +
Sbjct: 657 -EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHHL 714
Query: 323 LSA--SFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
L A S D +++ L + GH++ VN F+ D + S S+DGT+K+W+
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771
Score = 79.0 bits (193), Expect = 1e-14
Identities = 66/261 (25%), Positives = 117/261 (44%), Gaps = 22/261 (8%)
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
DAV CFS D + +A+ D ++V+K ++G+ L +AH V C +FS D I +
Sbjct: 616 DAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRFIAT 674
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISA--SSDGTVKIWNMKTTE 382
S D+ ++I +G+ + + HS VN FT H+++ A SSD +K+W++ E
Sbjct: 675 CSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 734
Query: 383 CSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGK--- 439
C NT G +VN P + + C+ T+ + + R + K
Sbjct: 735 CRNTM------FGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINVKQFF 787
Query: 440 ------REGGDFV--CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIA 491
+E + + CC+ S G I ++ ++ ++T + H V G+
Sbjct: 788 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVM 846
Query: 492 HHPHQNLIATYSEDGLLKLWK 512
P + T S+D ++LW+
Sbjct: 847 FSPDGSSFLTSSDDQTIRLWE 867
Score = 76.3 bits (186), Expect = 6e-14
Identities = 76/354 (21%), Positives = 132/354 (37%), Gaps = 79/354 (22%)
Query: 214 KSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFS 273
+ V C FS D +++ T SVD +++WN TG++ ++ V C F+
Sbjct: 657 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQ--------VNCCHFT 708
Query: 274 RDTE--MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
+ +LATG+ D +K+W + +C R H+ V FS D + S S D T+
Sbjct: 709 NSSHHLLLATGSSDCFLKLWDLNQKEC-RNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 767
Query: 332 RIHGLKSGK-----TLKEF----------------------------------------- 345
++ S +K+F
Sbjct: 768 KLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTD 827
Query: 346 --------RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTD 397
RGH S+V+ F+ DG +++S D T+++W K C N+ L
Sbjct: 828 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVV 886
Query: 398 ITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWI 457
N V++L V + +I GQI CC LSP ++I
Sbjct: 887 FQENEVMVL-------AVDHIRRLQLINGRTGQI------DYLTEAQVSCCCLSPHLQYI 933
Query: 458 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
E+ + V ++ ++ H+K V I + + + S+D +++W
Sbjct: 934 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 987
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/172 (29%), Positives = 78/172 (45%), Gaps = 19/172 (11%)
Query: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
L++ S DG ++VWN TG KD F+ VL S D ++ + D
Sbjct: 1015 LLSWSFDGTVKVWNIITGNKEKD--------FVCHQGTVLSCDISHDATKFSSTSADKTA 1066
Query: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL------ 342
K+W L R H+ V C +FS DS+ + + + IRI + +G+ L
Sbjct: 1067 KIWSFDLLLPLHEL-RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPL 1125
Query: 343 --KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGS 392
+ H +V + F+ DG +ISA G +K WN+ T E S TF + G+
Sbjct: 1126 SEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGT 1175
Score = 69.3 bits (168), Expect = 8e-12
Identities = 48/169 (28%), Positives = 80/169 (47%), Gaps = 11/169 (6%)
Query: 209 IKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVL 268
I + ++ V C SP QY+ G +G IE+ +I +Q++ V
Sbjct: 913 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI-----FQSR---FQHKKTVW 964
Query: 269 CMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFD 328
+ F+ D + L + + D +I+VW Q +C+ F R H + V K +S++LS SFD
Sbjct: 965 HIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLK-NSRLLSWSFD 1021
Query: 329 QTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
T+++ + +G K+F H V + D S S+D T KIW+
Sbjct: 1022 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1070
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 15/175 (8%)
Query: 210 KFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGK--IRKDLKYQAQDNFMMMDDAV 267
+F K V +F+ D + L++ S D I+VWN+ K + + +D ++ + +
Sbjct: 956 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRL 1015
Query: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
L F DG +KVW I +G + F H V S D+++ S S
Sbjct: 1016 LSWSF------------DGTVKVWNIITGNKEKDFV-CHQGTVLSCDISHDATKFSSTSA 1062
Query: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
D+T +I L E RGH+ V + F+ D + + +G ++IWN+ E
Sbjct: 1063 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1117
Score = 62.0 bits (149), Expect = 1e-09
Identities = 55/201 (27%), Positives = 92/201 (45%), Gaps = 38/201 (18%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKD----LKYQA----QDNFMMM 263
G S V FSPDG +T S D I +W T K+ K+ LK + Q+N +M+
Sbjct: 837 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMV 894
Query: 264 -----------------------DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLR 300
+ V C C S + +A G ++G I++ ++ + + +
Sbjct: 895 LAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQ 954
Query: 301 -RFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ 359
RF+ H K V + F+ D ++S+S D I++ + K + RGH V + +
Sbjct: 955 SRFQ--HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLK 1011
Query: 360 DGHYIISASSDGTVKIWNMKT 380
+ ++S S DGTVK+WN+ T
Sbjct: 1012 NSR-LLSWSFDGTVKVWNIIT 1031
Score = 59.7 bits (143), Expect = 6e-09
Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 7/132 (5%)
Query: 207 RHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQ-----AQDNFM 261
R+ FG + V RFSPD + L + S DG +++W+ T+ RK + + +D
Sbjct: 736 RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQE 795
Query: 262 MMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 321
M+ V C +S D + A++ KI +W S + R H V + FS D S
Sbjct: 796 DMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADC-RGHLSWVHGVMFSPDGSS 853
Query: 322 ILSASFDQTIRI 333
L++S DQTIR+
Sbjct: 854 FLTSSDDQTIRL 865
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 304 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHY 363
R H+ V FS+D +I S D+T+++ ++G+ L E + H V F+ D +
Sbjct: 612 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 671
Query: 364 IISASSDGTVKIWNMKTTECSNTF 387
I + S D VKIWN T E +T+
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTY 695
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 187 FRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTG 246
F +A K + F L H G V C+ FS D L TG +G I +WN + G
Sbjct: 1057 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1116
Query: 247 KIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF 302
++ +++ V +CFS D +ML + G IK W + +G+ + F
Sbjct: 1117 ELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1170
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 87.4 bits (215), Expect = 3e-17
Identities = 54/177 (30%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 203 TQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMM 262
T LSR + V A FS DGQ + + D ++V+ TG+ ++K
Sbjct: 593 TNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAH------- 645
Query: 263 MDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQI 322
+D VLC FS D +AT + D K+K+W +G+ + ++ HS+ V C F+ S +
Sbjct: 646 -EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDE-HSEQVNCCHFTNSSHHL 703
Query: 323 LSA--SFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
L A S D +++ L + GH++ VN F+ D + S S+DGT+K+W+
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760
Score = 79.0 bits (193), Expect = 1e-14
Identities = 66/261 (25%), Positives = 117/261 (44%), Gaps = 22/261 (8%)
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
DAV CFS D + +A+ D ++V+K ++G+ L +AH V C +FS D I +
Sbjct: 605 DAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCAFSTDDRFIAT 663
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISA--SSDGTVKIWNMKTTE 382
S D+ ++I +G+ + + HS VN FT H+++ A SSD +K+W++ E
Sbjct: 664 CSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKE 723
Query: 383 CSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGK--- 439
C NT G +VN P + + C+ T+ + + R + K
Sbjct: 724 CRNTM------FGHTNSVNHCRFSP-DDKLLASCSADGTLKLWDATSANERKSINVKQFF 776
Query: 440 ------REGGDFV--CCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIA 491
+E + + CC+ S G I ++ ++ ++T + H V G+
Sbjct: 777 LNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADCRGHLSWVHGVM 835
Query: 492 HHPHQNLIATYSEDGLLKLWK 512
P + T S+D ++LW+
Sbjct: 836 FSPDGSSFLTSSDDQTIRLWE 856
Score = 76.3 bits (186), Expect = 6e-14
Identities = 76/354 (21%), Positives = 132/354 (37%), Gaps = 79/354 (22%)
Query: 214 KSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFS 273
+ V C FS D +++ T SVD +++WN TG++ ++ V C F+
Sbjct: 646 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQ--------VNCCHFT 697
Query: 274 RDTE--MLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
+ +LATG+ D +K+W + +C R H+ V FS D + S S D T+
Sbjct: 698 NSSHHLLLATGSSDCFLKLWDLNQKEC-RNTMFGHTNSVNHCRFSPDDKLLASCSADGTL 756
Query: 332 RIHGLKSGK-----TLKEF----------------------------------------- 345
++ S +K+F
Sbjct: 757 KLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLWNTD 816
Query: 346 --------RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTD 397
RGH S+V+ F+ DG +++S D T+++W K C N+ L
Sbjct: 817 SRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVV 875
Query: 398 ITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWI 457
N V++L V + +I GQI CC LSP ++I
Sbjct: 876 FQENEVMVL-------AVDHIRRLQLINGRTGQI------DYLTEAQVSCCCLSPHLQYI 922
Query: 458 YCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
E+ + V ++ ++ H+K V I + + + S+D +++W
Sbjct: 923 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVW 976
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/172 (29%), Positives = 78/172 (45%), Gaps = 19/172 (11%)
Query: 229 LVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKI 288
L++ S DG ++VWN TG KD F+ VL S D ++ + D
Sbjct: 1004 LLSWSFDGTVKVWNIITGNKEKD--------FVCHQGTVLSCDISHDATKFSSTSADKTA 1055
Query: 289 KVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTL------ 342
K+W L R H+ V C +FS DS+ + + + IRI + +G+ L
Sbjct: 1056 KIWSFDLLLPLHEL-RGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPL 1114
Query: 343 --KEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGS 392
+ H +V + F+ DG +ISA G +K WN+ T E S TF + G+
Sbjct: 1115 SEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGT 1164
Score = 69.3 bits (168), Expect = 8e-12
Identities = 48/169 (28%), Positives = 80/169 (47%), Gaps = 11/169 (6%)
Query: 209 IKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVL 268
I + ++ V C SP QY+ G +G IE+ +I +Q++ V
Sbjct: 902 IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRI-----FQSR---FQHKKTVW 953
Query: 269 CMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFD 328
+ F+ D + L + + D +I+VW Q +C+ F R H + V K +S++LS SFD
Sbjct: 954 HIQFTADEKTLISSSDDAEIQVWNWQLDKCI--FLRGHQETVKDFRLLK-NSRLLSWSFD 1010
Query: 329 QTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWN 377
T+++ + +G K+F H V + D S S+D T KIW+
Sbjct: 1011 GTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1059
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 15/175 (8%)
Query: 210 KFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGK--IRKDLKYQAQDNFMMMDDAV 267
+F K V +F+ D + L++ S D I+VWN+ K + + +D ++ + +
Sbjct: 945 RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRL 1004
Query: 268 LCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASF 327
L F DG +KVW I +G + F H V S D+++ S S
Sbjct: 1005 LSWSF------------DGTVKVWNIITGNKEKDFV-CHQGTVLSCDISHDATKFSSTSA 1051
Query: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTE 382
D+T +I L E RGH+ V + F+ D + + +G ++IWN+ E
Sbjct: 1052 DKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGE 1106
Score = 62.0 bits (149), Expect = 1e-09
Identities = 55/201 (27%), Positives = 92/201 (45%), Gaps = 38/201 (18%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKD----LKYQA----QDNFMMM 263
G S V FSPDG +T S D I +W T K+ K+ LK + Q+N +M+
Sbjct: 826 GHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE--TKKVCKNSAVMLKQEVDVVFQENEVMV 883
Query: 264 -----------------------DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLR 300
+ V C C S + +A G ++G I++ ++ + + +
Sbjct: 884 LAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQ 943
Query: 301 -RFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ 359
RF+ H K V + F+ D ++S+S D I++ + K + RGH V + +
Sbjct: 944 SRFQ--HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCI-FLRGHQETVKDFRLLK 1000
Query: 360 DGHYIISASSDGTVKIWNMKT 380
+ ++S S DGTVK+WN+ T
Sbjct: 1001 NSR-LLSWSFDGTVKVWNIIT 1020
Score = 59.7 bits (143), Expect = 6e-09
Identities = 42/132 (31%), Positives = 65/132 (49%), Gaps = 7/132 (5%)
Query: 207 RHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQ-----AQDNFM 261
R+ FG + V RFSPD + L + S DG +++W+ T+ RK + + +D
Sbjct: 725 RNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQE 784
Query: 262 MMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 321
M+ V C +S D + A++ KI +W S + R H V + FS D S
Sbjct: 785 DMEVIVKCCSWSADGARIMVAAKN-KIFLWNTDSRSKVADC-RGHLSWVHGVMFSPDGSS 842
Query: 322 ILSASFDQTIRI 333
L++S DQTIR+
Sbjct: 843 FLTSSDDQTIRL 854
Score = 54.7 bits (130), Expect = 2e-07
Identities = 28/84 (33%), Positives = 44/84 (52%)
Query: 304 RAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHY 363
R H+ V FS+D +I S D+T+++ ++G+ L E + H V F+ D +
Sbjct: 601 RPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRF 660
Query: 364 IISASSDGTVKIWNMKTTECSNTF 387
I + S D VKIWN T E +T+
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTY 684
Score = 50.4 bits (119), Expect = 4e-06
Identities = 33/116 (28%), Positives = 51/116 (43%), Gaps = 2/116 (1%)
Query: 187 FRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTG 246
F +A K + F L H G V C+ FS D L TG +G I +WN + G
Sbjct: 1046 FSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNG 1105
Query: 247 KIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRF 302
++ +++ V +CFS D +ML + G IK W + +G+ + F
Sbjct: 1106 ELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTF 1159
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 85.9 bits (211), Expect = 8e-17
Identities = 52/178 (29%), Positives = 86/178 (48%), Gaps = 14/178 (7%)
Query: 199 EKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQD 258
+KF LS+HI + V CA+FSPDG+ +V+ S D +++W+ ++ + Y
Sbjct: 97 QKFLFSLSQHINW-----VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVH--SYCEHG 149
Query: 259 NFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKD 318
F+ D F +A D +KVW +++ + L+ ++ HS V LSF
Sbjct: 150 GFVTYVD------FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQ-LHSAAVNGLSFHPS 202
Query: 319 SSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW 376
+ +++AS D T++I L G+ L GH F++ G Y S SD V +W
Sbjct: 203 GNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 82.4 bits (202), Expect = 9e-16
Identities = 69/260 (26%), Positives = 112/260 (43%), Gaps = 21/260 (8%)
Query: 206 SRHIKF-GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMD 264
SR +F G K V C FSP G L +GS D + +W ++ + F
Sbjct: 14 SRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW---VPNVKGE-----STVFRAHT 65
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
V + F D + T + D +KVW + L + H V C FS D I+S
Sbjct: 66 ATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQ-HINWVRCAKFSPDGRLIVS 124
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECS 384
AS D+T+++ S + + + H FV F G I +A D TVK+W+++T
Sbjct: 125 ASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 184
Query: 385 NTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMN-MQGQIVRSFSSGKREGG 443
++ L S A VN + P + + + +T+ I++ M+G+++ + + G
Sbjct: 185 QHYQ-LHSAA-----VNGLSFHPSG-NYLITASSDSTLKILDLMEGRLLYTLHGHQ---G 234
Query: 444 DFVCCALSPRGEWIYCVGED 463
A S GE+ G D
Sbjct: 235 PATTVAFSRTGEYFASGGSD 254
Score = 82.4 bits (202), Expect = 9e-16
Identities = 62/248 (25%), Positives = 106/248 (42%), Gaps = 10/248 (4%)
Query: 265 DAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILS 324
DAV C+ FS +LA+G++D +++W + + + RAH+ V + F D ++
Sbjct: 24 DAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 82
Query: 325 ASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECS 384
AS D+T+++ K L H ++V A F+ DG I+SAS D TVK+W+ + EC
Sbjct: 83 ASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECV 142
Query: 385 NTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGD 444
+++ G V V P NTV + +++ R +
Sbjct: 143 HSYCEHGG------FVTYVDFHPSG-TCIAAAGMDNTVKVWDVRTH--RLLQHYQLHSAA 193
Query: 445 FVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSE 504
+ P G ++ D L + G+L TL H+ +A A+
Sbjct: 194 VNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 505 DGLLKLWK 512
D + +WK
Sbjct: 254 DEQVMVWK 261
Score = 48.5 bits (114), Expect = 1e-05
Identities = 53/216 (24%), Positives = 79/216 (36%), Gaps = 33/216 (15%)
Query: 328 DQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIW--NMK------ 379
D + + +K F GH V F+ GH + S S D TV+IW N+K
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 380 ----TTECSNTFKSLGS---TAGTDITV-------NSVILLPKNPEHFVVCNR---SNTV 422
T S F S G TA D TV + ++V C + +
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 423 VIMNMQGQIVRSFSSGKRE--------GGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTG 474
++ + V+ + RE GG P G I G D + + T
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 475 KLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKL 510
+L + +H V G++ HP N + T S D LK+
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 85.1 bits (209), Expect = 1e-16
Identities = 78/319 (24%), Positives = 149/319 (46%), Gaps = 32/319 (10%)
Query: 200 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
+ P + + + GQ + V RF+ DG Y +T D +++WN G + L+ +
Sbjct: 12 ELPQKRLKTLDCGQGA-VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTL---LRTYSGHG 67
Query: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
+ ++D A S D L +G D + +W + SGQ +R+F R H+ V + F++++
Sbjct: 68 YEVLDAAG-----SFDNSSLCSGGGDKAVVLWDVASGQVVRKF-RGHAGKVNTVQFNEEA 121
Query: 320 SQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 374
+ ILS S D +IR +S + TL E R S V + H I++ S DG V+
Sbjct: 122 TVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSD-----HEILAGSVDGRVR 176
Query: 375 IWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVR 433
++++ + + + G+ IT ++ + +V + +T+ +++ G+++
Sbjct: 177 RYDLRMGQLFSDY------VGSPITCTC---FSRDGQCTLVSSLDSTLRLLDKDTGELLG 227
Query: 434 SFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHH 493
+ K + CC LS R + ED ++ + V G L L V V +A+H
Sbjct: 228 EYKGHKNQEYKLDCC-LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYH 286
Query: 494 PHQNLIATYSEDGLLKLWK 512
P + + T + G ++ W+
Sbjct: 287 PTEPCLLT-AMGGSVQCWR 304
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 85.1 bits (209), Expect = 1e-16
Identities = 78/319 (24%), Positives = 149/319 (46%), Gaps = 32/319 (10%)
Query: 200 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
+ P + + + GQ + V RF+ DG Y +T D +++WN G + L+ +
Sbjct: 12 ELPQKRLKTLDCGQGA-VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTL---LRTYSGHG 67
Query: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
+ ++D A S D L +G D + +W + SGQ +R+F R H+ V + F++++
Sbjct: 68 YEVLDAAG-----SFDNSSLCSGGGDKAVVLWDVASGQVVRKF-RGHAGKVNTVQFNEEA 121
Query: 320 SQILSASFDQTIRIHGLKSGK-----TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVK 374
+ ILS S D +IR +S + TL E R S V + H I++ S DG V+
Sbjct: 122 TVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSVKVSD-----HEILAGSVDGRVR 176
Query: 375 IWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVR 433
++++ + + + G+ IT ++ + +V + +T+ +++ G+++
Sbjct: 177 RYDLRMGQLFSDY------VGSPITCTC---FSRDGQCTLVSSLDSTLRLLDKDTGELLG 227
Query: 434 SFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHH 493
+ K + CC LS R + ED ++ + V G L L V V +A+H
Sbjct: 228 EYKGHKNQEYKLDCC-LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYH 286
Query: 494 PHQNLIATYSEDGLLKLWK 512
P + + T + G ++ W+
Sbjct: 287 PTEPCLLT-AMGGSVQCWR 304
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 82.0 bits (201), Expect = 1e-15
Identities = 75/312 (24%), Positives = 131/312 (41%), Gaps = 23/312 (7%)
Query: 208 HIKFGQKSHVECARFSP-DGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDA 266
H+ G V R P G L++ S+D I++W G+ R+ L+ F+ A
Sbjct: 282 HVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWE-VYGE-RRCLR-----TFIGHSKA 334
Query: 267 VLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ---IL 323
V +CF+ + A D +K+W ++GQC+ RF + K C+ F+ D + +
Sbjct: 335 VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRF--TNRKVPYCVKFNPDEDKQNLFV 392
Query: 324 SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTEC 383
+ D+ I ++SG+ ++E+ H VN F + +S S D ++++W +
Sbjct: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEW---DI 449
Query: 384 SNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQI---VRSFSSGKR 440
FK + A + + L N + + N ++I Q + + G
Sbjct: 450 PVDFKYI---AEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHM 506
Query: 441 EGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQ-NLI 499
G SP ++ + L + T KL H+K IG HPH+ + +
Sbjct: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV 566
Query: 500 ATYSEDGLLKLW 511
T DGL+KLW
Sbjct: 567 ITCGWDGLIKLW 578
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 79.3 bits (194), Expect = 8e-15
Identities = 50/183 (27%), Positives = 88/183 (48%), Gaps = 11/183 (6%)
Query: 196 VEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQ 255
+ +EK ++L I +G V A FSPD YL++ S DG + +W+ T K
Sbjct: 527 IMDEKTASELK--ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH 584
Query: 256 AQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSF 315
N+ + D FS +G D ++W Q LR F H V C F
Sbjct: 585 ---NYPVWDTQ-----FSPYGYYFVSGGHDRVARLWATDHYQPLRIFA-GHLADVNCTRF 635
Query: 316 SKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKI 375
+S+ + + S D+T+R+ + +G ++ F GH ++ TF+ +G ++ + ++DG V +
Sbjct: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLL 695
Query: 376 WNM 378
W++
Sbjct: 696 WDI 698
Score = 68.6 bits (166), Expect = 1e-11
Identities = 57/239 (23%), Positives = 102/239 (42%), Gaps = 25/239 (10%)
Query: 275 DTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH 334
D+ ++A G D ++VW + + LR ++A + K+S +L D+
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKK-LRSVKQASDLSL----IDKESDDVLERIMDE----- 530
Query: 335 GLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA 394
K+ LK GHS V A+F+ D +Y++S+S DGTV++W+++T C +K
Sbjct: 531 --KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK------ 582
Query: 395 GTDITVNSVILLPKNPEHFVVCNRSNTVVIM--NMQGQIVRSFSSGKREGGDFVCCALSP 452
G + V P ++ V + V + Q +R F+ D C P
Sbjct: 583 GHNYPVWDTQFSPYG--YYFVSGGHDRVARLWATDHYQPLRIFAGHL---ADVNCTRFHP 637
Query: 453 RGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
++ D + + + G R T H+ + + P+ +AT + DG + LW
Sbjct: 638 NSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Score = 63.9 bits (154), Expect = 3e-10
Identities = 45/186 (24%), Positives = 80/186 (43%), Gaps = 24/186 (12%)
Query: 225 DGQYLVTGSVDGFIEVWNFTTGKIRK-------DLKYQAQDNFM--MMDD---------- 265
D + G D + VW+ T K+R L + D+ + +MD+
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540
Query: 266 ----AVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQ 321
V FS D L + ++DG +++W +Q+ CL + + H+ V FS
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY-KGHNYPVWDTQFSPYGYY 599
Query: 322 ILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTT 381
+S D+ R+ + L+ F GH + VN F + +Y+ + S+D TV++W++
Sbjct: 600 FVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNG 659
Query: 382 ECSNTF 387
C F
Sbjct: 660 NCVRIF 665
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 79.3 bits (194), Expect = 8e-15
Identities = 79/294 (26%), Positives = 132/294 (44%), Gaps = 30/294 (10%)
Query: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
+P G +L++ DG + TG F+ AV ++D AT
Sbjct: 26 TPYGYFLISACKDGKPMLRQGDTG--------DWIGTFLGHKGAVWGATLNKDATKAATA 77
Query: 283 AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGL-KSGKT 341
A D KVW SG L AH V + F++DS+ +L+ D+ +RI+ L K
Sbjct: 78 AADFTAKVWDAVSGDELMTL--AHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAE 135
Query: 342 LKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVN 401
KE GH+S + +A + + I+SA D TV++W+ T KSL +++V+
Sbjct: 136 PKEISGHTSGIKKALWCSEDKQILSAD-DKTVRLWDHATM---TEVKSLNF----NMSVS 187
Query: 402 SVILLPKNPEHFVVCNRS---NTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIY 458
S+ +P+ + RS ++ V ++ ++SF + +L P E++
Sbjct: 188 SMEYIPEGEILVITYGRSIAFHSAVSLDP----IKSFEAPATINS----ASLHPEKEFLV 239
Query: 459 CVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWK 512
GEDF LY + +G+ + H + + P L A+ SEDG L+LW+
Sbjct: 240 AGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQ 293
Score = 38.9 bits (89), Expect = 0.011
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 212 GQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGK 247
G + C RFSPDG+ +GS DG + +W GK
Sbjct: 263 GHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGK 298
Score = 37.0 bits (84), Expect = 0.043
Identities = 20/87 (22%), Positives = 43/87 (49%), Gaps = 8/87 (9%)
Query: 211 FGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCM 270
F + + A P+ ++LV G D + +++ +G+ + K + C+
Sbjct: 220 FEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHF--------GPIHCV 271
Query: 271 CFSRDTEMLATGAQDGKIKVWKIQSGQ 297
FS D E+ A+G++DG +++W+ G+
Sbjct: 272 RFSPDGELYASGSEDGTLRLWQTVVGK 298
Score = 35.8 bits (81), Expect = 0.096
Identities = 21/67 (31%), Positives = 32/67 (47%), Gaps = 1/67 (1%)
Query: 275 DTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIH 334
+ E L G +D K+ + SG+ L + + H + C+ FS D S S D T+R+
Sbjct: 234 EKEFLVAGGEDFKLYKYDYNSGEELESY-KGHFGPIHCVRFSPDGELYASGSEDGTLRLW 292
Query: 335 GLKSGKT 341
GKT
Sbjct: 293 QTVVGKT 299
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 79.3 bits (194), Expect = 8e-15
Identities = 44/164 (26%), Positives = 84/164 (51%), Gaps = 14/164 (8%)
Query: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
F PD Q + + S+D I++W+ T+ + +A N A+ CF+ L T
Sbjct: 238 FDPDSQRVASVSLDRCIKIWDVTSQATLLTIT-KAHSN------AISNCCFTFSGHFLCT 290
Query: 282 GAQDGKIKVWKIQSGQ------CLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHG 335
+ D +K+W + +G+ C+ + H V+ F++DSS ++S FD+T+ I
Sbjct: 291 SSWDKNLKIWNVHTGEFRNCGACVTLMQ-GHEGSVSSCHFARDSSFLISGGFDRTVAIWD 349
Query: 336 LKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMK 379
+ G +GH+ +V + + + +I+SAS D T+++WN++
Sbjct: 350 VAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIE 393
Score = 72.0 bits (175), Expect = 1e-12
Identities = 49/188 (26%), Positives = 90/188 (47%), Gaps = 12/188 (6%)
Query: 217 VECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDT 276
VEC+ + D ++ S D + W+ TGK+ ++Y D ++ FS D
Sbjct: 149 VECS-ITGDSSRVIAASYDKTVRAWDLETGKLLWKVRY---------DTFIVSCKFSPDG 198
Query: 277 EMLATGAQ-DGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHG 335
+ + +G D I + ++ + + H++ +T F DS ++ S S D+ I+I
Sbjct: 199 KYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWD 258
Query: 336 LKSGKTLKEF-RGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTA 394
+ S TL + HS+ ++ FT GH++ ++S D +KIWN+ T E N +
Sbjct: 259 VTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQ 318
Query: 395 GTDITVNS 402
G + +V+S
Sbjct: 319 GHEGSVSS 326
Score = 72.0 bits (175), Expect = 1e-12
Identities = 53/222 (23%), Positives = 106/222 (47%), Gaps = 28/222 (12%)
Query: 217 VECARFSPDGQYLVTG-SVDGFI---EVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCF 272
V C +FSPDG+Y+V+G VD I + N TT + KD ++ + CF
Sbjct: 190 VSC-KFSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRS----------ITSCCF 238
Query: 273 SRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIR 332
D++ +A+ + D IK+W + S L +AHS ++ F+ + ++S+D+ ++
Sbjct: 239 DPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLK 298
Query: 333 IHGLKSGK------TLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNT 386
I + +G+ + +GH V+ F +D ++IS D TV IW++ +
Sbjct: 299 IWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV-----AEG 353
Query: 387 FKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQ 428
++ L D ++ + + N + + ++ T+ + N++
Sbjct: 354 YRKLSLKGHNDWVMD--VAISNNKKWILSASKDRTMRLWNIE 393
Score = 62.0 bits (149), Expect = 1e-09
Identities = 34/103 (33%), Positives = 57/103 (55%), Gaps = 1/103 (0%)
Query: 264 DDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQIL 323
+ AV F D L +G+ D +K+W G +R FE V S + DSS+++
Sbjct: 102 EHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSSRVI 161
Query: 324 SASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIIS 366
+AS+D+T+R L++GK L + R + +F+ F+ DG Y++S
Sbjct: 162 AASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVS 203
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/106 (31%), Positives = 53/106 (50%), Gaps = 11/106 (10%)
Query: 277 EMLATGAQDGKIKV-WKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHG 335
E L G QD K+ +KI SG H V+ F D +++LS S+D T+++
Sbjct: 80 EKLIWGDQDPLSKIPFKILSG---------HEHAVSTCHFCVDDTKLLSGSYDCTVKLWD 130
Query: 336 LKSGKTLKEFRGHSSF-VNEATFTQDGHYIISASSDGTVKIWNMKT 380
G +++F V E + T D +I+AS D TV+ W+++T
Sbjct: 131 PVDGSVVRDFEHRPKAPVVECSITGDSSRVIAASYDKTVRAWDLET 176
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,497,853
Number of Sequences: 37866
Number of extensions: 785198
Number of successful extensions: 5311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 120
Number of HSP's that attempted gapping in prelim test: 2036
Number of HSP's gapped (non-prelim): 1799
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.