Guide to the Human Genome
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Search of human proteins with 148833504

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
         (1332 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148833504 interleukin 16 isoform 2 [Homo sapiens]                 2630   0.0  
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]        1236   0.0  
gi|87196343 PDZ domain containing 2 [Homo sapiens]                    229   1e-59
gi|148746189 multiple PDZ domain protein [Homo sapiens]                95   5e-19
gi|112382257 InaD-like [Homo sapiens]                                  83   2e-15
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ...    82   3e-15
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ...    82   3e-15
gi|45827729 scribble isoform b [Homo sapiens]                          81   8e-15
gi|45827731 scribble isoform a [Homo sapiens]                          81   8e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]           80   1e-14
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]           80   1e-14
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      78   5e-14
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]         77   8e-14
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    77   1e-13
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    77   1e-13
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]    76   2e-13
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    75   3e-13
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...    75   5e-13
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa...    75   5e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    74   9e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    74   9e-13
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    74   9e-13
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    74   9e-13
gi|157388993 synaptojanin 2 binding protein [Homo sapiens]             74   1e-12
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    72   3e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    71   6e-12
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      70   1e-11
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       70   1e-11
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ...    68   7e-11
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]       66   3e-10

>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
          Length = 1332

 Score = 2630 bits (6817), Expect = 0.0
 Identities = 1332/1332 (100%), Positives = 1332/1332 (100%)

Query: 1    MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS 60
            MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS
Sbjct: 1    MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS 60

Query: 61   VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA 120
            VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA
Sbjct: 61   VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA 120

Query: 121  QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL 180
            QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL
Sbjct: 121  QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL 180

Query: 181  DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 240
            DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG
Sbjct: 181  DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 240

Query: 241  PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR 300
            PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR
Sbjct: 241  PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR 300

Query: 301  TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK 360
            TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK
Sbjct: 301  TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK 360

Query: 361  EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE 420
            EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE
Sbjct: 361  EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE 420

Query: 421  VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES 480
            VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES
Sbjct: 421  VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES 480

Query: 481  SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS 540
            SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS
Sbjct: 481  SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS 540

Query: 541  THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP 600
            THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP
Sbjct: 541  THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP 600

Query: 601  PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC 660
            PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC
Sbjct: 601  PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC 660

Query: 661  PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC 720
            PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC
Sbjct: 661  PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC 720

Query: 721  IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK 780
            IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK
Sbjct: 721  IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK 780

Query: 781  KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR 840
            KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR
Sbjct: 781  KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR 840

Query: 841  QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP 900
            QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP
Sbjct: 841  QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP 900

Query: 901  EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP 960
            EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP
Sbjct: 901  EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP 960

Query: 961  SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE 1020
            SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE
Sbjct: 961  SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE 1020

Query: 1021 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS 1080
            GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS
Sbjct: 1021 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS 1080

Query: 1081 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT 1140
            VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT
Sbjct: 1081 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT 1140

Query: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200
            VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP
Sbjct: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200

Query: 1201 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP 1260
            EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP
Sbjct: 1201 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP 1260

Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS 1320
            LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS
Sbjct: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS 1320

Query: 1321 LQSKETTAAGDS 1332
            LQSKETTAAGDS
Sbjct: 1321 LQSKETTAAGDS 1332


>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
          Length = 631

 Score = 1236 bits (3197), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 702  MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 761
            MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL
Sbjct: 1    MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 60

Query: 762  DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 821
            DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA
Sbjct: 61   DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 120

Query: 822  SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 881
            SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG
Sbjct: 121  SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 180

Query: 882  RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 941
            RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL
Sbjct: 181  RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 240

Query: 942  LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 1001
            LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS
Sbjct: 241  LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 300

Query: 1002 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 1061
            LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL
Sbjct: 301  LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 360

Query: 1062 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 1121
            TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG
Sbjct: 361  TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 420

Query: 1122 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 1181
            AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI
Sbjct: 421  AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 480

Query: 1182 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 1241
            LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS
Sbjct: 481  LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 540

Query: 1242 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301
            AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW
Sbjct: 541  AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600

Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
            NIIKALPDGPVTIVIRRKSLQSKETTAAGDS
Sbjct: 601  NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631



 Score = 84.3 bits (207), Expect = 7e-16
 Identities = 64/225 (28%), Positives = 113/225 (50%), Gaps = 24/225 (10%)

Query: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277
           +L K +  GLGFS+ GG D     I ++   +F  G A+ +G +Q+G+E+L +NG+S+ G
Sbjct: 414 ILHKEEGAGLGFSLAGGADLENKVITVH--RVFPNGLASQEGTIQKGNEVLSINGKSLKG 471

Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337
            TH DAL   +QA++    + V  +LT          P     L+SST       S A  
Sbjct: 472 TTHHDALAILRQAREPRQAVIVTRKLT----------PEAMPDLNSST------DSAASA 515

Query: 338 SPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAH 394
           S ++ +S        +  V+L+K  AG+G  +  G  S+   + ++   ++ +  G+ + 
Sbjct: 516 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLT---INRIFKGAASE 572

Query: 395 LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
               ++ GDEI+++  + +  LT  E + I+     GPV I++ R
Sbjct: 573 QSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 38/107 (35%), Positives = 58/107 (54%), Gaps = 2/107 (1%)

Query: 196 SLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAA 255
           S S A  V      +A+V +  V ++  + GLGFS+ GGK S++G   + +  IF G A+
Sbjct: 514 SASAASDVSVESTAEATVCT--VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 571

Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302
                +Q GDEIL+L G +M GLT  +A    K    G +T+ +R +
Sbjct: 572 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 1/87 (1%)

Query: 358 LQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417
           L KE G GLG  L      +    I VH + P  +A  +G ++ G+E++ I+   +   T
Sbjct: 415 LHKEEGAGLGFSLAGGADLEN-KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473

Query: 418 LNEVYTILSHCDPGPVPIIVSRHPDPQ 444
            ++   IL         +IV+R   P+
Sbjct: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score =  229 bits (585), Expect = 1e-59
 Identities = 154/395 (38%), Positives = 216/395 (54%), Gaps = 23/395 (5%)

Query: 173 RKSLSQQLDCPAGKAAG--TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFS 230
           + SL Q LD  +         + TRSLST Q+  P   ++ SVIS I L K + KGLGFS
Sbjct: 541 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS 600

Query: 231 IVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
           I GG+D I G +GI+VKTIF  G+AA DGRL+EGDEIL++NG  + GLT Q+A+  FKQ 
Sbjct: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660

Query: 291 KKGLLTLTVRTRLTAPP----SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
           + GL  LTVRT+L +P     S  +H+S     + ++S   +   S     S S    T 
Sbjct: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG-SSSSLGRKTP 719

Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIV 406
            P  RI++EV+L KE  VGLGIG C +       GI++H+L+PGSVA ++  L  GD+I+
Sbjct: 720 GPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779

Query: 407 EISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKE 466
           E++   V    L++V+ ILS C PGPV +++ RHP+P+VSEQ++ E +A++       KE
Sbjct: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQE--SKE 837

Query: 467 RHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPH---RRAQKVMIRSSSDSSYMSGSPGG 523
            +     G      S   + +L  E E +    H         M+  S D  +       
Sbjct: 838 ANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDH------- 890

Query: 524 SPGSG--SAEKPSSDVDISTH-SPSLPLAREPVVL 555
            PGSG  ++E+ S     STH  P  P A   V L
Sbjct: 891 -PGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL 924



 Score =  208 bits (530), Expect = 2e-53
 Identities = 177/526 (33%), Positives = 264/526 (50%), Gaps = 60/526 (11%)

Query: 833  SSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKP-LGKHEEGRF-SGLLGR- 889
            S+S  S++QRI SFE   ++   D+   +    P    ++KP +G+   G   SG LG  
Sbjct: 2329 STSFFSVKQRIKSFENLANA---DRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHP 2385

Query: 890  -GAAPTLVPQQPEQVLSSGSPAASEARD--PGVSESPPP-----GRQPNQKTLPPGPDPL 941
              AA  L+ +     LSS S   SEA    P +++SP        RQ   +T   G D  
Sbjct: 2386 GDAAARLLRRS----LSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSE 2441

Query: 942  LRL------LSTQAEESQGPVLKMPS--QRARSFPLTRSQSCETKLL-----DEKTSKLY 988
            L+       + T       PV +  S  +  +  P++RS+  E + L     D+  S+ Y
Sbjct: 2442 LKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDY 2501

Query: 989  SISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGS------AET-- 1040
            S     S+ + K+ L     I+  ++P  P  G S        +   GS      AET  
Sbjct: 2502 SAGP--SAVLFKTEL----EITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPS 2555

Query: 1041 SALDTGFSL-NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099
            SA DTG +  +L   R ++  L +      GD   LQS  S +   S   +  LI+E K 
Sbjct: 2556 SASDTGEAAQDLPFRRSWSVNLDQLLVSA-GDQQRLQSVLSSVG--SKSTILTLIQEAKA 2612

Query: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 1159
              E      + +   +L+++EG+GLGFS+AGG D+E K ITVHRVF  G ASQEGT+ +G
Sbjct: 2613 QSENE----EDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRG 2668

Query: 1160 NEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAA 1219
            + +LS+NG SL G  H + L +L QA+  + A++V +K   +  P       +A      
Sbjct: 2669 DFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLL 2728

Query: 1220 SDVSV-------ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 1272
            S  ++        S A      V + K SAGLG SL+GGK S+ GD PL I R++KG A+
Sbjct: 2729 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAA 2788

Query: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
            EQ+  ++ GDEIL + G  + GL  F+AWNI+K++P+GPV ++IR+
Sbjct: 2789 EQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 69/232 (29%), Positives = 112/232 (48%), Gaps = 27/232 (11%)

Query: 1111 IHVTILHKEEGAGLGFSLAGGADL--ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
            I +  L+KE+G GLGFS+AGG D       I V  +FPNG A+++G +++G+E+L +NG 
Sbjct: 584  ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643

Query: 1169 SLKGTTHHDALAILRQARE-----PRQAVIVTRKLTPEAMP-------DLNSSTDSAASA 1216
             +KG T  +A+   +Q R        +  +V+  LTP + P         N +T   ASA
Sbjct: 644  PIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA 703

Query: 1217 SAASDVSVESTAEAT-------VCTVTLEK---MSAGLGFSLEGGKGSLHGDKPLTINRI 1266
              + + S  S    T       V  VTL K   +  G+G      + S  G   + I+ +
Sbjct: 704  GGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSL 760

Query: 1267 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
              G+ ++    +  GD+IL++    ++     +   I+   P GPV +VI R
Sbjct: 761  APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 69/228 (30%), Positives = 106/228 (46%), Gaps = 19/228 (8%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            IVL + +  GLGFS+ GG D    P  I V  +F+ GAA+ +G +  GD +L +NG S+A
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTD--VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLC--RSLSSSTCITKDSSSF 334
            GL H + L+   QA+     L V  +    P   +   PP    + L S   I  +    
Sbjct: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLE---- 2736

Query: 335  ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSV 392
                P    S A  +  + VEV L+  AG+GL +  G  SV        + +  +  G  
Sbjct: 2737 ----PGIGRSVAVHD-ALCVEV-LKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGA 2787

Query: 393  AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRH 440
            A   G +  GDEI+ I+  P+  L   + + I+     GPV +++ +H
Sbjct: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKH 2835



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 5/112 (4%)

Query: 223 QAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQD 282
           ++ GLG  + GG+ S   P  I V  +  GGAA  DGRL  GDE+L +NG  + GL+H++
Sbjct: 340 ESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399

Query: 283 ALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           A+   + A  G++ L V ++  +   L    S    +SL   T   +D SS+
Sbjct: 400 AVAILRSA-TGMVQLVVASKENSAEDLLRLTS----KSLPDLTSSVEDVSSW 446



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)

Query: 1119 EEGAGLGFSLAGGADLENK--VITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
            +E  GLG  ++GG   +     I V +V   G A ++G +  G+E+L ING  L G +H 
Sbjct: 339  KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398

Query: 1177 DALAILRQAREPRQAVIVTR--------KLTPEAMPDLNSSTDSAAS 1215
            +A+AILR A    Q V+ ++        +LT +++PDL SS +  +S
Sbjct: 399  EAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 6/165 (3%)

Query: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAA 1214
            ++++ NE++  NG           L + R  R+     ++      +    +  ST S +
Sbjct: 514  SVEEYNELMVRNGDP-----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568

Query: 1215 SASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQ 1274
            +    S   +   +  ++  +  EK   GLGFS+ GG+  + G   + +  IF   ++ +
Sbjct: 569  TTQVESPWRLIRPSVISIIGLYKEK-GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627

Query: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
               ++ GDEIL + G  ++GLT  EA +  K +  G   + +R K
Sbjct: 628  DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 1/89 (1%)

Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
            L K S GLG  + GG+GS      + + ++ +G A+ +   +  GDE+L + G  + GL+
Sbjct: 337  LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396

Query: 1297 RFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
              EA  I+++   G V +V+  K   +++
Sbjct: 397  HEEAVAILRS-ATGMVQLVVASKENSAED 424



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 1/57 (1%)

Query: 382 IFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVS 438
           I V  +  G  AH DGRL  GDE++ I+   +  L+  E   IL     G V ++V+
Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSA-TGMVQLVVA 416



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 72/331 (21%), Positives = 109/331 (32%), Gaps = 48/331 (14%)

Query: 493  EKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREP 552
            E  S P   R  K   RS     +  GSP  SPG  +A  P      S    S P     
Sbjct: 1263 ENPSQPASPRVTKCKARSPVRLPH-EGSP--SPGEKAAAPPDYSKTRSASETSTPHNTRR 1319

Query: 553  VV-----------LSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSK-PKPP 600
            V            ++ A + LP +     E R   P    K      +  P SS+ P   
Sbjct: 1320 VAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLL 1379

Query: 601  PRKYFKSDSDPQKSLE-----ERENSSCS--SGHTPPTCGQEA--RELLPLLLPQEDTAG 651
                  S   PQ SL      +    +C   SGH  P   +E+   ++   +   + +A 
Sbjct: 1380 EGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAA 1439

Query: 652  RSPSASAGCPGP-----------GIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQA 700
            RSPS+  G  G            G G  +    E  PG + +SP  +      P   + A
Sbjct: 1440 RSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSP-RRAWAAGAPAYPQWA 1498

Query: 701  RMDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPK 760
                  D+   D    ++    + +S   S  H            +     G  D T P 
Sbjct: 1499 SQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFH-----------EDSTSLSGLGDSTEPS 1547

Query: 761  LDTANGTPKVYKSADSSTVKKGPPVAPKPAW 791
            L +  G  +   S+D  ++ + P  + +  W
Sbjct: 1548 LSSMYGDAE-DSSSDPESLTEAPRASARDGW 1577


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 94.7 bits (234), Expect = 5e-19
 Identities = 65/219 (29%), Positives = 113/219 (51%), Gaps = 7/219 (3%)

Query: 1103 ATLKQLDGIHVTILHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGN 1160
            A   ++ G+    + K     LG S+AGG  + L +  I +  + P G+A+Q   ++ G+
Sbjct: 1823 ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGD 1882

Query: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 1220
             +++I G S +G TH  A+ +L+ A    +  +V                 S+ S +  +
Sbjct: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLT 1942

Query: 1221 DVSV--ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-KGAASEQSET 1277
              S+  +        ++TLE+   GLGFS+ GG GS HGD P+ +  +F KGAASE    
Sbjct: 1943 SSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGR- 2001

Query: 1278 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316
            ++ GD+I+ + G +++G+T  EA  I+K    G VT+++
Sbjct: 2002 LKRGDQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 69/211 (32%), Positives = 113/211 (53%), Gaps = 26/211 (12%)

Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM-AG 277
           L+K  + GLGFS+VG +    G +GI+V+ I  G  A  DGRL+E D+IL +NG+++   
Sbjct: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199

Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337
           +THQ A+   ++AK  +  +  R  L   P L   +SP + RS S+++ I+  S+     
Sbjct: 200 ITHQQAISILQKAKDTVQLVIARGSL---PQL---VSPIVSRSPSAASTISAHSN----- 248

Query: 338 SPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDG 397
               P+     +++ M  + L  + G GLG G+         +G+ V T+ PG VA   G
Sbjct: 249 ----PV-----HWQHMETIELVND-GSGLGFGIIGGK----ATGVIVKTILPGGVADQHG 294

Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
           RL  GD I++I D+ +  ++  +V  +L  C
Sbjct: 295 RLCSGDHILKIGDTDLAGMSSEQVAQVLRQC 325



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 44/84 (52%), Positives = 62/84 (73%), Gaps = 2/84 (2%)

Query: 216  NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
            +I L +G   GLGFSIVGG  S +G + IYVKT+FA GAA+ DGRL+ GD+I+ +NG+S+
Sbjct: 1958 SITLERGP-DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSL 2016

Query: 276  AGLTHQDALQKFKQAKKGLLTLTV 299
             G+TH++A+   K+  KG +TL V
Sbjct: 2017 EGVTHEEAVAILKRT-KGTVTLMV 2039



 Score = 81.6 bits (200), Expect = 4e-15
 Identities = 74/258 (28%), Positives = 113/258 (43%), Gaps = 51/258 (19%)

Query: 173  RKSLSQQLDCP-AGKAAGTSRPTRSLSTAQLVQPSGGLQASVI----SNIVLMKGQAKGL 227
            +K+ SQ L  P +G     S    S S+   +  S      +I    + I + KG+  GL
Sbjct: 1581 KKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRT-GL 1639

Query: 228  GFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKF 287
            G SIVGG D++ G I I+   ++  GAA  DGRL  GD+ILE+NG  +   TH +A+   
Sbjct: 1640 GLSIVGGSDTLLGAIIIH--EVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697

Query: 288  KQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAK 347
            +Q  +       R RLT       +    +C +L+                         
Sbjct: 1698 RQTPQ-------RVRLTLYRDEAPYKEEEVCDTLT------------------------- 1725

Query: 348  PNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVE 407
                    + LQK+ G GLG+   S+   +  +G+FV  +  G +A  DGRL  GD+I+ 
Sbjct: 1726 --------IELQKKPGKGLGL---SIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILM 1774

Query: 408  ISDSPVHCLTLNEVYTIL 425
            ++   V   T   V  +L
Sbjct: 1775 VNGEDVRNATQEAVAALL 1792



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 62/226 (27%), Positives = 98/226 (43%), Gaps = 15/226 (6%)

Query: 1114 TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            TI    +G+GLGF + GG   +   + V  + P G+A Q G +  G+ +L I    L G 
Sbjct: 257  TIELVNDGSGLGFGIIGG---KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGM 313

Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS---DVSVESTAEA 1230
            +      +LRQ     + +I    +     P     T S++  S      D S +   E+
Sbjct: 314  SSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEES 373

Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-----KGAASEQSETVQPGDEIL 1285
                V L K   GLG ++ G      GDK L  + IF     K +A E    +Q GD+I+
Sbjct: 374  ETFDVELTKNVQGLGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429

Query: 1286 QLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
             + GT +QG T  +A  +++      +  ++RR   Q  E  +  D
Sbjct: 430  AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSRED 475



 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 65/230 (28%), Positives = 113/230 (49%), Gaps = 14/230 (6%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I L KG + GLG S+ G KD     + +++  I   GAA  DGRLQ  DE+LE+NG+ + 
Sbjct: 1351 IELEKGHS-GLGLSLAGNKDR--SRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILY 1407

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTR-LTAPPSLC-SHLSPPLCRSLSSSTCITKDSSSF 334
            G +HQ+A    K A   +  + +R +      ++C  +   PL    S+S  +    +  
Sbjct: 1408 GRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPL---PSNSENLQNKETEP 1464

Query: 335  ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAH 394
             + +  A +  +  +++ +  + L K+ G GLGI +        +SG+ + +L+   VA 
Sbjct: 1465 TVTTSDAAVDLS--SFKNVQHLELPKDQG-GLGIAISEE---DTLSGVIIKSLTEHGVAA 1518

Query: 395  LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 444
             DGRL+ GD+I+ + D  V    + +  ++L          I + +PD Q
Sbjct: 1519 TDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQ 1568



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 69/277 (24%), Positives = 125/277 (45%), Gaps = 33/277 (11%)

Query: 1030 EDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEE 1089
            E+ AA       A D    +N  +LR+ T         D+  +   Q+ Q V   L  +E
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATH--------DEAINVLRQTPQRVRLTLYRDE 1712

Query: 1090 LKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGL 1149
                 +E +V D  T++         L K+ G GLG S+ G  +  +  + V  +   G+
Sbjct: 1713 AP--YKEEEVCDTLTIE---------LQKKPGKGLGLSIVGKRN--DTGVFVSDIVKGGI 1759

Query: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209
            A  +G + +G+++L +NG+ ++  T     A+L+         +    L+    P   SS
Sbjct: 1760 ADADGRLMQGDQILMVNGEDVRNATQEAVAALLK---------VSEGSLSSFTFPLSGSS 1810

Query: 1210 TDSAASASAASDVSVESTAEATVCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268
            T  +  +S+  +            TV ++K  +  LG S+ GG GS  GD P+ I  +  
Sbjct: 1811 TSESLESSSKKNALASEIQGLR--TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1868

Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
               + Q++ ++ GD I+ + GT+ +G+T  +A N++K
Sbjct: 1869 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 35/201 (17%)

Query: 1101 DEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGN 1160
            D AT   + G   TI   +   GLG S+ GG+D     I +H V+  G A ++G +  G+
Sbjct: 1616 DPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGD 1675

Query: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 1220
            ++L +NG  L+  TH +A+ +LRQ              TP+ +  L    D A       
Sbjct: 1676 QILEVNGIDLRKATHDEAINVLRQ--------------TPQRV-RLTLYRDEA------- 1713

Query: 1221 DVSVESTAEATVC-TVTLE---KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
                    E  VC T+T+E   K   GLG S+ G +     D  + ++ I KG  ++   
Sbjct: 1714 -----PYKEEEVCDTLTIELQKKPGKGLGLSIVGKR----NDTGVFVSDIVKGGIADADG 1764

Query: 1277 TVQPGDEILQLGGTAMQGLTR 1297
             +  GD+IL + G  ++  T+
Sbjct: 1765 RLMQGDQILMVNGEDVRNATQ 1785



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 69/239 (28%), Positives = 100/239 (41%), Gaps = 39/239 (16%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I L K   KGLG SIVG ++      G++V  I  GG A ADGRL +GD+IL +NGE + 
Sbjct: 1726 IELQKKPGKGLGLSIVGKRNDT----GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
              T Q+A+    +  +G L               S  + PL  S S+S  +   S   AL
Sbjct: 1782 NAT-QEAVAALLKVSEGSL---------------SSFTFPLSGS-STSESLESSSKKNAL 1824

Query: 337  ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
             S    + T +        + +    GVG  +G   VP       IF+  + P  VA   
Sbjct: 1825 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLG--DVP-------IFIAMMHPTGVAAQT 1875

Query: 397  GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCD---------PGPVPIIVSRHPDPQVS 446
             +LR GD IV I  +    +T  +   +L +            G V ++     +P  S
Sbjct: 1876 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASS 1934



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 69/275 (25%), Positives = 114/275 (41%), Gaps = 26/275 (9%)

Query: 171  SNRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASV-----ISNIVLMKGQAK 225
            + +++++  L    G  +  + P    ST++ ++ S    A       +  + + KG   
Sbjct: 1783 ATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTD 1842

Query: 226  GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
             LG SI GG  S  G + I++  +   G AA   +L+ GD I+ + G S  G+TH  A+ 
Sbjct: 1843 SLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVN 1902

Query: 286  KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIST 345
              K A   +    V     +   +  H   P   SLS     T  +SS   +    P   
Sbjct: 1903 LLKNASGSIEMQVVAGGDVSV--VTGHQQEPASSSLS----FTGLTSSSIFQDDLGP--- 1953

Query: 346  AKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVAHLDGRLRCG 402
              P  +     S+  E G   G+G   V  +    G   I+V T+     A  DGRL+ G
Sbjct: 1954 --PQCK-----SITLERGPD-GLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRG 2005

Query: 403  DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437
            D+I+ ++   +  +T  E   IL     G V ++V
Sbjct: 2006 DQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 90/407 (22%), Positives = 160/407 (39%), Gaps = 47/407 (11%)

Query: 55  GIFHSSVQLADTSEA-GPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSRE 113
           GIF  S+  +   E  G   + D  +A +   LQ   N +     R        T   R 
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463

Query: 114 KPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSA--APTDRQPYSLCS 171
              + E  S   +   A    +  N++ +     ++ DF  + ++    PT+ + Y L S
Sbjct: 464 MKQEAELMSREDVTKDA--DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLS 521

Query: 172 NRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSI 231
               + +  D    +AA  ++  R +          G+   ++   V    +  GLG S+
Sbjct: 522 --AEIEEIEDAQKQEAALLTKWQRIM----------GINYEIVVAHVSKFSENSGLGISL 569

Query: 232 VGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAK 291
               ++  G    +++++   G     G+L  GDE+LE+NG ++ G  HQD +   K+  
Sbjct: 570 ----EATVGHH--FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623

Query: 292 KGLLTLTVRTRLTAPPSLCSHL-SPPLC-----------------RSLSSSTCITKDSSS 333
             +    V  R T PP+  S L S  LC                  S +    +    + 
Sbjct: 624 --IEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAG 681

Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEA-GVGLGIGLCSVPYFQCISGIFVHTLSPGSV 392
            + E   AP++  +   +    + L+K + G+G  I     P     + I + +L PG +
Sbjct: 682 QSTEEVQAPLAMWEAGIQ---HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738

Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
           A  DGRL  GD ++ ++D  +   +L E    L     G V I V++
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 72/299 (24%), Positives = 119/299 (39%), Gaps = 49/299 (16%)

Query: 1065 KEDDDGDHSSLQSGQSVISLLSSEE----LKKLIEEVKVLD--EATL----KQLDGIH-- 1112
            KE+ + D   L S ++   L + EE    L   IEE++     EA L    +++ GI+  
Sbjct: 491  KENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYE 550

Query: 1113 VTILHKE---EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 1169
            + + H     E +GLG SL            +  V P G     G +  G+E+L +NG +
Sbjct: 551  IVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606

Query: 1170 LKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL----------------------- 1206
            L G  H D + IL++       V   R + P    +L                       
Sbjct: 607  LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666

Query: 1207 NSSTDSAASASAASDVSVESTA------EATVCTVTLEKMSAGLGFSLEGGKGSLH-GDK 1259
            +S T+    A   +  S E         EA +  + LEK S GLGFS+   +  +     
Sbjct: 667  SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAST 726

Query: 1260 PLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
             + I  +  G  +E+   + PGD ++ +    ++  +  EA   +K  P G V I + +
Sbjct: 727  VIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 68/314 (21%)

Query: 217  IVLMKGQAKGLGFSIVGGKDS----IYGPI--GIYVKTIFAGGAAAADGRLQEGDEILEL 270
            + L +  +K LG SIVGG+        G +  GI++K +     A  +G L+ GD I+E+
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211

Query: 271  NGESMAGLTHQDALQKFKQAKKGLL----TLTVRTRLTAPPSLCSHLSP--------PLC 318
            +G  +   +H+ A++  ++A   ++    ++  R R +  PSL  +L P        P  
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFA 1271

Query: 319  RSLSSSTCITKDSSSFALESPSAPISTAKP-----------------NYRIMVEVSLQKE 361
             SL  +    K  S    E   AP+ +  P                   +I  +V  + E
Sbjct: 1272 DSLQINA--DKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE 1329

Query: 362  AGV--------------------------GLGIGLCSVPYFQCISGIFVHTLSPGSVAHL 395
             G                           GLG+ L        +S +F+  + P   A  
Sbjct: 1330 FGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMS-VFIVGIDPNGAAGK 1388

Query: 396  DGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVA 455
            DGRL+  DE++EI+   ++  +     +I+  C P  V II  R+ D   +  Q+     
Sbjct: 1389 DGRLQIADELLEINGQILYGRSHQNASSIIK-CAPSKVKIIFIRNKD---AVNQMAVCPG 1444

Query: 456  QAVENTKFGKERHQ 469
             AVE      E  Q
Sbjct: 1445 NAVEPLPSNSENLQ 1458



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 18/197 (9%)

Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170
            +H+  L K   +GLG SLAG  D     + +  + PNG A ++G +Q  +E+L ING+ L
Sbjct: 1348 LHMIELEKGH-SGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406

Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRK--------LTPEAMPDLNSSTDSAASAS----- 1217
             G +H +A +I++ A    + + +  K            A+  L S++++  +       
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466

Query: 1218 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 1277
              SD +V+ ++   V  + L K   GLG ++   + +L G   + I  + +   +     
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSG---VIIKSLTEHGVAATDGR 1522

Query: 1278 VQPGDEILQLGGTAMQG 1294
            ++ GD+IL +    + G
Sbjct: 1523 LKVGDQILAVDDEIVVG 1539



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 64/266 (24%), Positives = 111/266 (41%), Gaps = 47/266 (17%)

Query: 225 KGLGFSIVGG-KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
           +GLG +I G   D    P GI+VK+I    A   DGR+Q GD+I+ ++G ++ G T+Q A
Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444

Query: 284 LQKFKQAKKGLLTLTVRTRLTAPPSLCSH--------LSPPLCRSLSSS-------TCIT 328
           ++  +   + +L   +R  +     L S         LSP     +  +          T
Sbjct: 445 VEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSST 504

Query: 329 KDSSSFALESPSAPISTAK-----------------------PNYRIMVEVSLQKEAGVG 365
           ++++    E    P+ +A+                        NY I+V    +     G
Sbjct: 505 RNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSG 564

Query: 366 LGIGLCSVPYFQCISGIFVHTLSP-GSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTI 424
           LGI L +      +   F+ ++ P G V H  G+L  GDE++E++   +      +V  I
Sbjct: 565 LGISLEAT-----VGHHFIRSVLPEGPVGH-SGKLFSGDELLEVNGITLLGENHQDVVNI 618

Query: 425 LSHCDPGPVPIIVSRHPDPQVSEQQL 450
           L    P  V ++  R   P  ++ +L
Sbjct: 619 LKEL-PIEVTMVCCRRTVPPTTQSEL 643



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 74/303 (24%), Positives = 123/303 (40%), Gaps = 41/303 (13%)

Query: 172  NRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASV-------ISNIVLMKGQA 224
            N+ +++Q   CP          + +L   +         A+V       + ++ L K Q 
Sbjct: 1432 NKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG 1491

Query: 225  KGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDAL 284
             GLG +I   +D++ G I   +K++   G AA DGRL+ GD+IL ++ E + G   +  +
Sbjct: 1492 -GLGIAI-SEEDTLSGVI---IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFI 1546

Query: 285  QKFKQAKKGLLTLTVRTR---LTAPPSLCSHLSPPLCRSLSS---------------STC 326
               K AK   + LT+        A PS     S     S  S               +T 
Sbjct: 1547 SLLKTAKM-TVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605

Query: 327  ITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG-IFVH 385
             +   + FA +  + PI    P     +E+S  +      G+GL  V     + G I +H
Sbjct: 1606 RSSTPAIFASDPATCPII---PGCETTIEISKGRT-----GLGLSIVGGSDTLLGAIIIH 1657

Query: 386  TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445
             +     A  DGRL  GD+I+E++   +   T +E   +L    P  V + + R   P  
Sbjct: 1658 EVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ-TPQRVRLTLYRDEAPYK 1716

Query: 446  SEQ 448
             E+
Sbjct: 1717 EEE 1719



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 55/238 (23%), Positives = 112/238 (47%), Gaps = 34/238 (14%)

Query: 1116 LHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
            L K++G GLG +++    L   +I    +  +G+A+ +G ++ G+++L+++ + + G   
Sbjct: 1486 LPKDQG-GLGIAISEEDTLSGVIIK--SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542

Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDL---------NSST------------DSAA 1214
               +++L+ A+   +  I       +A+P           NSS             +S  
Sbjct: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602

Query: 1215 SASAASDVSVESTAEATV-----CTVTLE--KMSAGLGFSLEGGKGSLHGDKPLTINRIF 1267
            + S +S  ++ ++  AT      C  T+E  K   GLG S+ GG  +L G   + I+ ++
Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG--AIIIHEVY 1660

Query: 1268 KGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
            +  A+ +   +  GD+IL++ G  ++  T  EA N+++  P   V + + R     KE
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ-RVRLTLYRDEAPYKE 1717



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 36/111 (32%), Positives = 59/111 (53%), Gaps = 3/111 (2%)

Query: 198 STAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIY-GPIGIYVKTIFAGGAAA 256
           ST ++  P    +A  I +I L KG +KGLGFSI+  +D I      I ++++  GG A 
Sbjct: 683 STEEVQAPLAMWEAG-IQHIELEKG-SKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAE 740

Query: 257 ADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 307
            DGRL  GD ++ +N  ++   + ++A++  K A  G + + V   L   P
Sbjct: 741 KDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 61/245 (24%), Positives = 98/245 (40%), Gaps = 28/245 (11%)

Query: 184  AGKAAGTSRPTRSLS-TAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI 242
            AGK +       SL+  A+ V      + S    I + KG +  LG ++   KD +    
Sbjct: 975  AGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSS-LGMTVSANKDGL---- 1029

Query: 243  GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302
            G+ V++I  GGA + DGR+  GD IL +N ES   +T+  A    +  +  L+   ++  
Sbjct: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR--RHSLIGPDIKIT 1087

Query: 303  LTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAP------------ISTAKPNY 350
               P          L +       +   SS    + P  P             +TA  N+
Sbjct: 1088 Y-VPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNW 1146

Query: 351  RIMVEVSLQKEAGVGLGIGLCS-------VPYFQCISGIFVHTLSPGSVAHLDGRLRCGD 403
                 V L +E    LGI +         +   + + GIF+  +   S A  +G L+ GD
Sbjct: 1147 NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGD 1206

Query: 404  EIVEI 408
             IVE+
Sbjct: 1207 RIVEV 1211



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 60/279 (21%), Positives = 102/279 (36%), Gaps = 71/279 (25%)

Query: 1095 EEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEG 1154
            EE +  D    K + G+ +TI              G   LE   I V  +  +     +G
Sbjct: 371  EESETFDVELTKNVQGLGITIA----------GYIGDKKLEPSGIFVKSITKSSAVEHDG 420

Query: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQARE-----------PRQAVIVTRK------ 1197
             IQ G+++++++G +L+G T+  A+ +LR   +            ++A +++R+      
Sbjct: 421  RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA 480

Query: 1198 -LTP----------EAMPDLNSSTDS--------------AASASAASDVSVESTA---- 1228
             L+P          E   D  SST +              +A      D   +  A    
Sbjct: 481  DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540

Query: 1229 ---------EATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ 1279
                     E  V  V+    ++GLG SLE   G         I  +        S  + 
Sbjct: 541  WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHF------IRSVLPEGPVGHSGKLF 594

Query: 1280 PGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
             GDE+L++ G  + G    +  NI+K LP     +  RR
Sbjct: 595  SGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRR 633



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 36/147 (24%), Positives = 60/147 (40%), Gaps = 16/147 (10%)

Query: 1200 PEAMPDLNSSTDSAASASAASDVSVES--------------TAEATVCTVTLEKMSAGLG 1245
            P A  ++ S    ++++  + DV  E               T    +  + LEK  +GLG
Sbjct: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361

Query: 1246 FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
             SL G K        + I  I    A+ +   +Q  DE+L++ G  + G +   A +IIK
Sbjct: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419

Query: 1306 ALPDGPVTIVIRRKSLQSKETTAAGDS 1332
              P     I IR K   ++     G++
Sbjct: 1420 CAPSKVKIIFIRNKDAVNQMAVCPGNA 1446



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 2/86 (2%)

Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGL 1295
            L+  S GLGFS+ G +    G+  + +  I +G+ + +   ++  D+IL + G A+ Q +
Sbjct: 141  LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200

Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSL 1321
            T  +A +I++   D  V +VI R SL
Sbjct: 201  THQQAISILQKAKD-TVQLVIARGSL 225


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 68/238 (28%), Positives = 108/238 (45%), Gaps = 33/238 (13%)

Query: 210 QASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILE 269
           Q   I  I + +    GLGFS+V  +    G + I+VK +  G  A  D RL+E D+IL 
Sbjct: 128 QGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILA 187

Query: 270 LNGESM-AGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCIT 328
           +N   +   ++HQ A+   +Q    L  +  R  +                        T
Sbjct: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH-----------------------T 224

Query: 329 KDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLS 388
           K S+S +L   + P +     +  + EV L  + G GLG G+         SG+ V T+ 
Sbjct: 225 KSSTSSSLNDTTLPETVC---WGHVEEVELIND-GSGLGFGIVGGK----TSGVVVRTIV 276

Query: 389 PGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVS 446
           PG +A  DGRL+ GD I++I  + V  +T  +V  +L +C    V ++V+R P   +S
Sbjct: 277 PGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG-NSVRMLVARDPAGDIS 333



 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 70/223 (31%), Positives = 106/223 (47%), Gaps = 47/223 (21%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I + KG++ GLG SIVGGKD+    I I+   ++  GAAA DGRL  GD+ILE+NG  + 
Sbjct: 1438 IEISKGRS-GLGLSIVGGKDTPLNAIVIH--EVYEEGAAARDGRLWAGDQILEVNGVDLR 1494

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
              +H++A+   +Q  +       + RL                       + +D + +  
Sbjct: 1495 NSSHEEAITALRQTPQ-------KVRLV----------------------VYRDEAHYRD 1525

Query: 337  ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
            E           N  I   V LQK+AG GLG+   S+   +  SG+F+  +  G  A LD
Sbjct: 1526 EE----------NLEIF-PVDLQKKAGRGLGL---SIVGKRNGSGVFISDIVKGGAADLD 1571

Query: 397  GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
            GRL  GD+I+ ++   +   +   V TIL  C  G V + + R
Sbjct: 1572 GRLIQGDQILSVNGEDMRNASQETVATILK-CAQGLVQLEIGR 1613



 Score = 77.8 bits (190), Expect = 6e-14
 Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 24/203 (11%)

Query: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
           GLGF IVGGK S     G+ V+TI  GG A  DGRLQ GD IL++ G ++ G+T +   Q
Sbjct: 257 GLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311

Query: 286 KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIST 345
             +         +VR  +   P+    ++PP   +L  +        + A + P +  S 
Sbjct: 312 VLRNCGN-----SVRMLVARDPAGDISVTPPAPAALPVAL------PTVASKGPGSDSSL 360

Query: 346 AKPNYRIMVEVSLQKEAGVGLGI---GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCG 402
            +        V L ++ G  LGI   G     +    SGI+V ++ PGS A+ +G ++  
Sbjct: 361 FE-----TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415

Query: 403 DEIVEISDSPVHCLTLNEVYTIL 425
           D+IV +    +     ++V  +L
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVL 438



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 46/345 (13%)

Query: 978  KLLDEKTSKLYSISSQVSSAVMKS------LLCLPSSISCAQTPCIPKEGASPTSSSNED 1031
            +LL+     LY  S Q +SA++K+      L+ + +  +  Q    P    S + SS ED
Sbjct: 1286 ELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIED 1345

Query: 1032 SAAN---GSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSE 1088
             +      S E  +++ G    L E   +   +++ K+       S  S +  ++  SS 
Sbjct: 1346 QSGTEPISSEEDGSVEVGIK-QLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSY 1404

Query: 1089 ELKKL-------IEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITV 1141
                         +    +D AT   + G  + I   +  +GLG S+ GG D     I +
Sbjct: 1405 HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVI 1464

Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPE 1201
            H V+  G A+++G +  G+++L +NG  L+ ++H +A+  LRQ  +  + V+        
Sbjct: 1465 HEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY------- 1517

Query: 1202 AMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKP 1260
                               +          +  V L+K +  GLG S+ G +        
Sbjct: 1518 -----------------RDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNG----SG 1556

Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            + I+ I KG A++    +  GD+IL + G  M+  ++     I+K
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 55/215 (25%), Positives = 97/215 (45%), Gaps = 22/215 (10%)

Query: 1120 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179
            +G+GLGF + GG   +   + V  + P GLA ++G +Q G+ +L I G +++G T     
Sbjct: 254  DGSGLGFGIVGG---KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310

Query: 1180 AILRQ---------AREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 1230
             +LR          AR+P   + V    TP A   L  +  + AS    SD S+  T   
Sbjct: 311  QVLRNCGNSVRMLVARDPAGDISV----TPPAPAALPVALPTVASKGPGSDSSLFETYNV 366

Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKP--LTINRIFKGAASEQSETVQPGDEILQLG 1288
             +    + K    LG  + G  G+ H  +   + +  I  G+A+  +  +Q  D+I+ + 
Sbjct: 367  EL----VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422

Query: 1289 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 1323
            G  +QG    +   +++         ++RRK+  S
Sbjct: 423  GVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457



 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 62/269 (23%), Positives = 121/269 (44%), Gaps = 27/269 (10%)

Query: 1041 SALDTGFSLNLSELREYTEG-LTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099
            S     F  +   L  +T+G +T        ++S++         L +E+   +I+++  
Sbjct: 69   SDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQM-- 126

Query: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAG--GADLENKVITVHRVFPNGLASQEGTIQ 1157
               A  +Q++ I +    +    GLGFS+      +L    I V  V P  +A ++  ++
Sbjct: 127  ---AQGRQIEYIDI---ERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK 180

Query: 1158 KGNEVLSINGKSL-KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
            + +++L+IN   L +  +H  A+A+L+Q     + ++    +           T S+ S+
Sbjct: 181  ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPV----------HTKSSTSS 230

Query: 1217 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
            S       E+     V  V L    +GLGF + GGK S      + +  I  G  +++  
Sbjct: 231  SLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDG 285

Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
             +Q GD IL++GGT +QG+T  +   +++
Sbjct: 286  RLQTGDHILKIGGTNVQGMTSEQVAQVLR 314



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 29/232 (12%)

Query: 1101 DEATLKQLDGIHV--TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQK 1158
            DEA  +  + + +    L K+ G GLG S+ G  +     + +  +   G A  +G + +
Sbjct: 1519 DEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQ 1576

Query: 1159 GNEVLSINGKSLKGTTHHDALAILRQAREPRQAVI--------VTRKLTPEAMPDLNSST 1210
            G+++LS+NG+ ++  +      IL+ A+   Q  I         + + T +       S 
Sbjct: 1577 GDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSA 1636

Query: 1211 DSAASASAA---------------SDVSVESTA-EATVCTVTLEK-MSAGLGFSLEGGKG 1253
             S+   S A               SD S +++  +    TV + + +S  LG S+ GG+G
Sbjct: 1637 HSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696

Query: 1254 SLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            S  GD P+ I  I     + +++ ++ GD I+ + G  + GL+  +  N++K
Sbjct: 1697 SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 29/226 (12%)

Query: 219  LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGL 278
            L K   +GLG SIVG ++      G+++  I  GGAA  DGRL +GD+IL +NGE M   
Sbjct: 1536 LQKKAGRGLGLSIVGKRNGS----GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591

Query: 279  THQDALQKFKQAKKGLLTLTV---------RTRLTAPPSLCSHLSPPLCRSLSSSTCITK 329
            + Q+ +    +  +GL+ L +           R T+  S  S  S       S +  IT 
Sbjct: 1592 S-QETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITG 1650

Query: 330  DSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC--------SVPYFQCISG 381
              +    +  S P             V + +E    LGI +          +P       
Sbjct: 1651 LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIP------- 1703

Query: 382  IFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
            +F+  +    VA    +L+ GD IV I+  P+  L+  +V  +L +
Sbjct: 1704 VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 73/301 (24%)

Query: 216  NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
            +I+ ++    GLG S+ G KD     + I+V  I   G AAADGR++ GDE+LE+N + +
Sbjct: 1238 HIIELEKDKNGLGLSLAGNKDR--SRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295

Query: 276  AGLTHQDALQKFKQAKKGLLTLTVR-----TRLTAPPSLCSHLSPPLCRSLSSSTCITK- 329
             G +HQ+A    K A   +  + +R      ++   P      SP      S +  I+  
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355

Query: 330  -------------DSSSFAL-------------------ESPSAPIST------------ 345
                         +S SF L                   E P AP S+            
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415

Query: 346  --------------AKPNYRIMVEVSLQKEAGVGLGI-GLCSVPYFQCISGIFVHTLSPG 390
                            P   +++E+S +  +G+GL I G    P    ++ I +H +   
Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEIS-KGRSGLGLSIVGGKDTP----LNAIVIHEVYEE 1470

Query: 391  SVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQL 450
              A  DGRL  GD+I+E++   +   +  E  T L    P  V ++V R       E+ L
Sbjct: 1471 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQ-TPQKVRLVVYRDEAHYRDEENL 1529

Query: 451  K 451
            +
Sbjct: 1530 E 1530



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 10/129 (7%)

Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170
            +H+  L K++  GLG SLAG  D     I V  + P G A+ +G ++ G+E+L IN + L
Sbjct: 1237 LHIIELEKDKN-GLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295

Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRK-------LTPEAMPDLNSSTDSAASASAASDVS 1223
             G +H +A AI++ A    + V +  +       +TP  +P  +SS  S    S    +S
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP--SSSPSSIEDQSGTEPIS 1353

Query: 1224 VESTAEATV 1232
             E      V
Sbjct: 1354 SEEDGSVEV 1362



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 46/196 (23%), Positives = 85/196 (43%), Gaps = 11/196 (5%)

Query: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200
            +  +   G     G +Q  +E+L +NG  L G +  +A++ L++   P   V   R    
Sbjct: 583  ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDD 642

Query: 1201 EAMPDLNSSTDSAASASAAS---DVSVESTAEATVCT-------VTLEKMSAGLGFSLEG 1250
            EA  D    T+++   +      DV+ E   +  +         V L K   GLGFS+  
Sbjct: 643  EASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD 702

Query: 1251 GKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD 1309
             +  L   + + + R +     +E+S  + PGD ++ +    +   +  EA  I+KA+P 
Sbjct: 703  YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPP 762

Query: 1310 GPVTIVIRRKSLQSKE 1325
            G V + I +  ++  E
Sbjct: 763  GLVHLGICKPLVEDNE 778



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 30/89 (33%), Positives = 50/89 (56%), Gaps = 1/89 (1%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LG SI GG+ S  G I +++  I A G AA   +L+ GD I+ +NG+ + GL+H D +  
Sbjct: 1687 LGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNL 1746

Query: 287  FKQA-KKGLLTLTVRTRLTAPPSLCSHLS 314
             K A  + +L +   T ++A  +   ++S
Sbjct: 1747 LKNAYGRIILQVVADTNISAIAAQLENMS 1775



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 47/254 (18%)

Query: 227  LGFSIVGGKDSIYGPI------GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTH 280
            LG SIVGG+  I          GI++K +     A     L+ GD+ILE++G  +   +H
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138

Query: 281  QDALQKFKQAKKGLL----TLTVRTRL----------------------------TAPPS 308
             +A++  K A   ++    +L+   R+                            TAPP 
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198

Query: 309  LCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI 368
            +     PP  ++L+  +   ++  +F  +      +       I   + L+K+   GLG+
Sbjct: 1199 M---KLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHI---IELEKDKN-GLGL 1251

Query: 369  GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
             L        +S IFV  ++P   A  DGR+R GDE++EI++  ++  +      I+   
Sbjct: 1252 SLAGNKDRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTA 1310

Query: 429  DPGPVPIIVSRHPD 442
             P  V ++  R+ D
Sbjct: 1311 -PSKVKLVFIRNED 1323



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 65/316 (20%)

Query: 183 PAGKAAGTSRPTRSLSTA--QLVQPSGGLQASVIS--NIVLMKGQAKGLGFSIVG--GKD 236
           PAG  + T     +L  A   +     G  +S+    N+ L++   + LG  IVG  G  
Sbjct: 328 PAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTS 387

Query: 237 SIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLT 296
                 GIYVK+I  G AA  +G +Q  D+I+ ++G ++ G  + D ++  + A + +  
Sbjct: 388 HTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447

Query: 297 LTVRTRLTA------PPS----LCSHLSPP---LCRSLSSSTCI-------------TKD 330
             VR + ++      PPS    +   L PP   L  ++ + T +              K+
Sbjct: 448 TLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKN 507

Query: 331 SSSFALES----PSAPISTAK--------PNYRIMV---------EVSLQKEA------G 363
            +  ALE     P +P +  K        P+Y +MV         +  LQK +       
Sbjct: 508 DNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHT 567

Query: 364 VGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYT 423
           + LG+ + S      IS I    +S G V  L G L+  DE++E++   ++  +  E  +
Sbjct: 568 LRLGVEVDSFDGHHYISSI----VSGGPVDTL-GLLQPEDELLEVNGMQLYGKSRREAVS 622

Query: 424 ILSHCDPGPVPIIVSR 439
            L    P P  ++  R
Sbjct: 623 FLKEVPP-PFTLVCCR 637



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 50/254 (19%), Positives = 96/254 (37%), Gaps = 52/254 (20%)

Query: 1116 LHKEEGAGLGFSLAGGADL--------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
            + +E    LG S+ GG  +        E K I + +V  +  A +   ++ G+++L ++G
Sbjct: 1071 IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSG 1130

Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS---------- 1217
              L+  +H +A+  ++ A  P   ++ +   TP  +P++++  +                
Sbjct: 1131 VDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEK 1190

Query: 1218 ----------------AASDVSVESTAE----------------ATVCTVTLEKMSAGLG 1245
                            A +D S E+  E                  +  + LEK   GLG
Sbjct: 1191 RQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLG 1250

Query: 1246 FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
             SL G K        + +  I     +     ++ GDE+L++    + G +   A  IIK
Sbjct: 1251 LSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308

Query: 1306 ALPDGPVTIVIRRK 1319
              P     + IR +
Sbjct: 1309 TAPSKVKLVFIRNE 1322



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 47/190 (24%), Positives = 76/190 (40%), Gaps = 7/190 (3%)

Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLT 304
           Y+ +I +GG     G LQ  DE+LE+NG  + G + ++A+   K+       +  R    
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641

Query: 305 APPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEA-G 363
              S+     P    +    T +  +      E     ++   P  +I   V L K+  G
Sbjct: 642 DEASVD---EPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKI---VELVKDCKG 695

Query: 364 VGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYT 423
           +G  I     P     S I + +L    VA   G L  GD +V +++  +   +L E   
Sbjct: 696 LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVE 755

Query: 424 ILSHCDPGPV 433
           IL    PG V
Sbjct: 756 ILKAVPPGLV 765



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 4/93 (4%)

Query: 1116 LHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLK 1171
            L +++G  LG  + G        E   I V  + P   A   G IQ  +++++++G +++
Sbjct: 368  LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427

Query: 1172 GTTHHDALAILRQAREPRQAVIVTRKLTPEAMP 1204
            G  +HD + +LR A +     +V RK +    P
Sbjct: 428  GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSP 460



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 21/72 (29%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            +++E    LG S+AGG  + L +  + +  +  +G+A++   ++ G+ ++SING+ L G 
Sbjct: 1679 INRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738

Query: 1174 THHDALAILRQA 1185
            +H D + +L+ A
Sbjct: 1739 SHADVVNLLKNA 1750



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 8/86 (9%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPL---TINRIFKGAASEQSETVQPGDEILQLGGTA 1291
            + + K  +GLG S+ GGK     D PL    I+ +++  A+ +   +  GD+IL++ G  
Sbjct: 1438 IEISKGRSGLGLSIVGGK-----DTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492

Query: 1292 MQGLTRFEAWNIIKALPDGPVTIVIR 1317
            ++  +  EA   ++  P     +V R
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYR 1518



 Score = 36.6 bits (83), Expect = 0.17
 Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 1/84 (1%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYV-KTIFAGGAAAADGRLQEGDEILELNGESM 275
           IV +    KGLGFSI+  +D +     + V +++ A G A   G L  GD ++ +N   +
Sbjct: 686 IVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745

Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299
              +  +A++  K    GL+ L +
Sbjct: 746 DNTSLAEAVEILKAVPPGLVHLGI 769



 Score = 34.7 bits (78), Expect = 0.63
 Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 7/102 (6%)

Query: 1218 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 1277
            A  D  +   AE    +  L   +  LG  ++   G  +      I+ I  G   +    
Sbjct: 544  ATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHY------ISSIVSGGPVDTLGL 597

Query: 1278 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
            +QP DE+L++ G  + G +R EA + +K +P  P T+V  R+
Sbjct: 598  LQPEDELLEVNGMQLYGKSRREAVSFLKEVPP-PFTLVCCRR 638



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 26/137 (18%)

Query: 1050 NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD 1109
            ++ E R     L E + D + D ++ +     ++L S E   K++E VK           
Sbjct: 645  SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEV--KIVELVK----------- 691

Query: 1110 GIHVTILHKEEGAGLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166
                      +  GLGFS+       D    VI +  +  +G+A + G +  G+ ++S+N
Sbjct: 692  ----------DCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741

Query: 1167 GKSLKGTTHHDALAILR 1183
               L  T+  +A+ IL+
Sbjct: 742  EYCLDNTSLAEAVEILK 758



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 17/90 (18%), Positives = 49/90 (54%), Gaps = 2/90 (2%)

Query: 1241 SAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGLTRFE 1299
            + GLGFS+   +    G   + +  +  G+ +++ + ++  D+IL +  T + Q ++  +
Sbjct: 142  TGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201

Query: 1300 AWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329
            A  +++    G + +++ R+ + +K +T++
Sbjct: 202  AIALLQQ-TTGSLRLIVAREPVHTKSSTSS 230


>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
           [Homo sapiens]
          Length = 1104

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%)

Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
           +K   +GLGF++V    SI+GP  I+VK I   GAA  DGRLQ GD ILE+NG  + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
            ++ +   +  K+G     V  R         H  P   R L        D  + +LE+ 
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491

Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397
                    + ++  E+ L      GLG+ L      +  +  GIF+ ++  G  A  DG
Sbjct: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542

Query: 398 RLRCGDEIVEIS 409
           RLR  D+++ ++
Sbjct: 543 RLRMNDQLIAVN 554



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)

Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
            I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 410  IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469

Query: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257
                +P +L    D  A       +S+E++ + T      +  SAGLG SL+G K    G
Sbjct: 470  EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522

Query: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310
             D  + I  I  G A+ +   ++  D+++ + G ++ G +  EA   ++          G
Sbjct: 523  TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582

Query: 1311 PVTIVIRRKSLQSKETTA 1328
             + +VI R+  +  E  A
Sbjct: 583  MIQLVILRRPERPMEDPA 600



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
           I L    + GLG S+ G K    G  +GI++K+I  GGAA  DGRL+  D+++ +NGES+
Sbjct: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558

Query: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326
            G ++ +A++  +++       +G++ L +  R   P   P+ C   S P   +  ++  
Sbjct: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618

Query: 327 ITKDSSSFALESPSAPISTAKP 348
            ++ + +  L     P+ T  P
Sbjct: 619 TSRRNDNSILH----PLGTCSP 636



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
            DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 342  DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385

Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
            L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 386  LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
            + E   ++++   G   ++VI R+
Sbjct: 446  QEELVAMLRSTKQGETASLVIARQ 469



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%)

Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
           + T  L  P      S ++  V + G+   LG  +V    S+ G I G++++ I     +
Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242

Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
             +G   E + I+++N   +   T   A   F+QA K     L  L  + R     S+  
Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302

Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
            L+              PP+         +L+ +     D+S+   +  SP  P    KP
Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362

Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
           +   +              +++ L+K      G+G   V     I G   IFV  + P  
Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
            A  DGRL+ GD I+E++   V   T  E+  +L     G    +V    +     ++LK
Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479


>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
           [Homo sapiens]
          Length = 1136

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%)

Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
           +K   +GLGF++V    SI+GP  I+VK I   GAA  DGRLQ GD ILE+NG  + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
            ++ +   +  K+G     V  R         H  P   R L        D  + +LE+ 
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491

Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397
                    + ++  E+ L      GLG+ L      +  +  GIF+ ++  G  A  DG
Sbjct: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542

Query: 398 RLRCGDEIVEIS 409
           RLR  D+++ ++
Sbjct: 543 RLRMNDQLIAVN 554



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)

Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
            I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 410  IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469

Query: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257
                +P +L    D  A       +S+E++ + T      +  SAGLG SL+G K    G
Sbjct: 470  EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522

Query: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310
             D  + I  I  G A+ +   ++  D+++ + G ++ G +  EA   ++          G
Sbjct: 523  TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582

Query: 1311 PVTIVIRRKSLQSKETTA 1328
             + +VI R+  +  E  A
Sbjct: 583  MIQLVILRRPERPMEDPA 600



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
           I L    + GLG S+ G K    G  +GI++K+I  GGAA  DGRL+  D+++ +NGES+
Sbjct: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558

Query: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326
            G ++ +A++  +++       +G++ L +  R   P   P+ C   S P   +  ++  
Sbjct: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618

Query: 327 ITKDSSSFALESPSAPISTAKP 348
            ++ + +  L     P+ T  P
Sbjct: 619 TSRRNDNSILH----PLGTCSP 636



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
            DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 342  DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385

Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
            L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 386  LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
            + E   ++++   G   ++VI R+
Sbjct: 446  QEELVAMLRSTKQGETASLVIARQ 469



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%)

Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
           + T  L  P      S ++  V + G+   LG  +V    S+ G I G++++ I     +
Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242

Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
             +G   E + I+++N   +   T   A   F+QA K     L  L  + R     S+  
Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302

Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
            L+              PP+         +L+ +     D+S+   +  SP  P    KP
Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362

Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
           +   +              +++ L+K      G+G   V     I G   IFV  + P  
Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
            A  DGRL+ GD I+E++   V   T  E+  +L     G    +V    +     ++LK
Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%)

Query: 801  NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 860
            +R S  + L  P        A+ E  G   RA+   S ++    S E   S   P     
Sbjct: 443  SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497

Query: 861  RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 914
                QP SG    PL   EE R S   G     R +A T+   +PE   +     +  EA
Sbjct: 498  ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551

Query: 915  RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 973
               G  E      Q  + T+    D LL     + EE Q      +P  R R   L R  
Sbjct: 552  TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606

Query: 974  SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 1026
            +   K       K + IS       + +LL         + P  P           +P +
Sbjct: 607  TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657

Query: 1027 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 1086
               E+    GS +    +        E R   E  +  +ED +G   ++ S  SV  +  
Sbjct: 658  QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709

Query: 1087 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 1141
             +    LIE  ++ +E        + +TIL +    GLG S+AGG        +++ I +
Sbjct: 710  DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760

Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 1188
             RV   G A++ G ++ G+++L +NG +L+G  HH+A+  LR A              EP
Sbjct: 761  SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819

Query: 1189 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 1247
              AV +T  L PE   D  S  +          +  ES        V  L +   GLGFS
Sbjct: 820  ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875

Query: 1248 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 1289
            + GGKGS     GD  + ++RI +G A+ ++ T+Q GD +L + G
Sbjct: 876  IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 17/240 (7%)

Query: 216  NIVLMKGQAKGLGFSIVGGKDSI---YGPIGIYVKTIFAGGAAAADGRLQEGDEILELNG 272
            ++  +    +GLGFSI GGK S     G  GI+V  I  GGAA   G LQ GD +L +NG
Sbjct: 861  HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920

Query: 273  ESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAPPSLCSHLSPPLCR-SLSSSTCITKD 330
              +    H  A+     A   +  L  R      PPS   H SPP    + +S T  T  
Sbjct: 921  VDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980

Query: 331  SSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGL------CSVPYFQCISGIFV 384
                   +PS   +  +  Y +  E+ L + AG  LG+ +       S P+     G+F+
Sbjct: 981  VPGLPSLAPSLLAAALEGPYPV-EEIRLPR-AGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038

Query: 385  HTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE-VYTILSHCDPGPVPIIVSRHPDP 443
              + P  +A   G LR GD I+ ++   V   T  E V  +L  C    + ++V R P P
Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAP 1095



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 115/503 (22%), Positives = 180/503 (35%), Gaps = 97/503 (19%)

Query: 227  LGFSIVGGKDSIYGPIGI-----YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
            LG SIVGG D    P G+     ++  +   G AA  G L+ GD IL +NG+ +   THQ
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQ 1072

Query: 282  DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341
            +A+    +    L +L VR R  APP L                CI K            
Sbjct: 1073 EAVSALLRPCLEL-SLLVR-RDPAPPGL-------------RELCIQK------------ 1105

Query: 342  PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRC 401
                  P  R+ + +        G   G    P      GIF+  +SP   A  DGRLR 
Sbjct: 1106 -----APGERLGISIR-------GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153

Query: 402  GDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENT 461
            G  ++E++   +  LT  E   +L         ++       + S     E     + N 
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF---EASTDAALEVSPGVIANP 1210

Query: 462  KFGKERHQWSLEGVKRLESS------------------WHGRPTLEKEREKNSAPPHRRA 503
                  H+ SLE +  ++                    W    T    R         RA
Sbjct: 1211 FAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRA 1270

Query: 504  QKVMIRSSSDSSYMSGSPGG----SPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIAS 559
               +  + S     SG+ GG    SP S S ++P S         ++  A      ++ +
Sbjct: 1271 LAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYR-AFAAVPT 1329

Query: 560  SRLPQES---PPLPESRDSHPPLRLK---KSFEILVRKPMSSKPKPPPRKYFKSDSDPQK 613
            S  P+++   PP P    S   L  +   K FE+ VR P +   + PP++     +D  +
Sbjct: 1330 SHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQA---EGPPKRVSLVGADDLR 1386

Query: 614  SLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSST 673
             ++E E              Q+  ++L       + A     A     G  +G + +   
Sbjct: 1387 KMQEEEARKLQ---------QKRAQML------REAAEAGAEARLALDGETLGEEEQE-- 1429

Query: 674  EGEPGWRRASPVTQTSPIKHPLL 696
            + +P W   SP ++ SP   P L
Sbjct: 1430 DEQPPWASPSPTSRQSPASPPPL 1452



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 22/237 (9%)

Query: 223 QAKGLGFSIVGGKDSIY---GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
           Q  GLG SI GGK S        GI++  +   G AA  G ++ GD++LE+NG ++ G  
Sbjct: 734 QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAE 792

Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
           H +A++  + A   +     R R+  P +  +    PL      S    ++     L  P
Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVT--ITPLRPEDDYS---PRERRGGGLRLP 847

Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAHLDG 397
             P  +  P  +  V    + E G+G  I  G  S PY    +GIFV  ++ G  AH  G
Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907

Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDP-----------GPVPIIVSRHPDP 443
            L+ GD ++ I+   V     +   ++L+   P           GP+P     H  P
Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%)

Query: 1112 HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166
            HV  L + E  GLGFS+AGG         +  I V R+   G A + GT+Q G+ VLSIN
Sbjct: 861  HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919

Query: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 1217
            G  +    H  A+++L  A  P  A+++ R+    L P  +P  +  T + A+ S     
Sbjct: 920  GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978

Query: 1218 ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 1265
                     A S ++        V  + L +    LG S+ G  GS H   P  +     
Sbjct: 979  PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036

Query: 1266 -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
                 + +G A+     ++ GD IL + G  ++  T  EA + +   P   +++++RR
Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%)

Query: 1070 GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 1125
            GD     +GQ V      E +  L+     L+ + L + D    G+    + K  G  LG
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112

Query: 1126 FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
             S+ GGA        D  ++ I + +V P G A ++G ++ G  +L +N +SL G TH +
Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 1217
            A+ +LR          V   LT        +STD+A   S
Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 214  ISNIVLMKGQAKGLGFSIVGGKDSIYG------PIGIYVKTIFAGGAAAADGRLQEGDEI 267
            +  + + K   + LG SI GG     G        GI++  +   GAA  DGRL+ G  +
Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRL 1157

Query: 268  LELNGESMAGLTHQDALQKFKQAKKGLLTL 297
            LE+N +S+ GLTH +A+Q  +     L  L
Sbjct: 1158 LEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%)

Query: 1215 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 1270
            S   A+++ +E +  E    T+T+ + + GLG S+ GGKGS      D+ + I+R+ +  
Sbjct: 708  SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767

Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 1300
             + ++  V+ GD++L++ G A+QG    EA
Sbjct: 768  PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 80.9 bits (198), Expect = 8e-15
 Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%)

Query: 801  NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 860
            +R S  + L  P        A+ E  G   RA+   S ++    S E   S   P     
Sbjct: 443  SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497

Query: 861  RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 914
                QP SG    PL   EE R S   G     R +A T+   +PE   +     +  EA
Sbjct: 498  ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551

Query: 915  RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 973
               G  E      Q  + T+    D LL     + EE Q      +P  R R   L R  
Sbjct: 552  TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606

Query: 974  SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 1026
            +   K       K + IS       + +LL         + P  P           +P +
Sbjct: 607  TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657

Query: 1027 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 1086
               E+    GS +    +        E R   E  +  +ED +G   ++ S  SV  +  
Sbjct: 658  QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709

Query: 1087 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 1141
             +    LIE  ++ +E        + +TIL +    GLG S+AGG        +++ I +
Sbjct: 710  DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760

Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 1188
             RV   G A++ G ++ G+++L +NG +L+G  HH+A+  LR A              EP
Sbjct: 761  SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819

Query: 1189 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 1247
              AV +T  L PE   D  S  +          +  ES        V  L +   GLGFS
Sbjct: 820  ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875

Query: 1248 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 1289
            + GGKGS     GD  + ++RI +G A+ ++ T+Q GD +L + G
Sbjct: 876  IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 17/240 (7%)

Query: 216  NIVLMKGQAKGLGFSIVGGKDSI---YGPIGIYVKTIFAGGAAAADGRLQEGDEILELNG 272
            ++  +    +GLGFSI GGK S     G  GI+V  I  GGAA   G LQ GD +L +NG
Sbjct: 861  HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920

Query: 273  ESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAPPSLCSHLSPPLCR-SLSSSTCITKD 330
              +    H  A+     A   +  L  R      PPS   H SPP    + +S T  T  
Sbjct: 921  VDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980

Query: 331  SSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGL------CSVPYFQCISGIFV 384
                   +PS   +  +  Y +  E+ L + AG  LG+ +       S P+     G+F+
Sbjct: 981  VPGLPSLAPSLLAAALEGPYPV-EEIRLPR-AGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038

Query: 385  HTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE-VYTILSHCDPGPVPIIVSRHPDP 443
              + P  +A   G LR GD I+ ++   V   T  E V  +L  C    + ++V R P P
Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAP 1095



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 115/503 (22%), Positives = 180/503 (35%), Gaps = 97/503 (19%)

Query: 227  LGFSIVGGKDSIYGPIGI-----YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
            LG SIVGG D    P G+     ++  +   G AA  G L+ GD IL +NG+ +   THQ
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQ 1072

Query: 282  DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341
            +A+    +    L +L VR R  APP L                CI K            
Sbjct: 1073 EAVSALLRPCLEL-SLLVR-RDPAPPGL-------------RELCIQK------------ 1105

Query: 342  PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRC 401
                  P  R+ + +        G   G    P      GIF+  +SP   A  DGRLR 
Sbjct: 1106 -----APGERLGISIR-------GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153

Query: 402  GDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENT 461
            G  ++E++   +  LT  E   +L         ++       + S     E     + N 
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF---EASTDAALEVSPGVIANP 1210

Query: 462  KFGKERHQWSLEGVKRLESS------------------WHGRPTLEKEREKNSAPPHRRA 503
                  H+ SLE +  ++                    W    T    R         RA
Sbjct: 1211 FAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRA 1270

Query: 504  QKVMIRSSSDSSYMSGSPGG----SPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIAS 559
               +  + S     SG+ GG    SP S S ++P S         ++  A      ++ +
Sbjct: 1271 LAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYR-AFAAVPT 1329

Query: 560  SRLPQES---PPLPESRDSHPPLRLK---KSFEILVRKPMSSKPKPPPRKYFKSDSDPQK 613
            S  P+++   PP P    S   L  +   K FE+ VR P +   + PP++     +D  +
Sbjct: 1330 SHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQA---EGPPKRVSLVGADDLR 1386

Query: 614  SLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSST 673
             ++E E              Q+  ++L       + A     A     G  +G + +   
Sbjct: 1387 KMQEEEARKLQ---------QKRAQML------REAAEAGAEARLALDGETLGEEEQE-- 1429

Query: 674  EGEPGWRRASPVTQTSPIKHPLL 696
            + +P W   SP ++ SP   P L
Sbjct: 1430 DEQPPWASPSPTSRQSPASPPPL 1452



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 22/237 (9%)

Query: 223 QAKGLGFSIVGGKDSIY---GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
           Q  GLG SI GGK S        GI++  +   G AA  G ++ GD++LE+NG ++ G  
Sbjct: 734 QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAE 792

Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
           H +A++  + A   +     R R+  P +  +    PL      S    ++     L  P
Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVT--ITPLRPEDDYS---PRERRGGGLRLP 847

Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAHLDG 397
             P  +  P  +  V    + E G+G  I  G  S PY    +GIFV  ++ G  AH  G
Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907

Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDP-----------GPVPIIVSRHPDP 443
            L+ GD ++ I+   V     +   ++L+   P           GP+P     H  P
Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%)

Query: 1112 HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166
            HV  L + E  GLGFS+AGG         +  I V R+   G A + GT+Q G+ VLSIN
Sbjct: 861  HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919

Query: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 1217
            G  +    H  A+++L  A  P  A+++ R+    L P  +P  +  T + A+ S     
Sbjct: 920  GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978

Query: 1218 ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 1265
                     A S ++        V  + L +    LG S+ G  GS H   P  +     
Sbjct: 979  PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036

Query: 1266 -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
                 + +G A+     ++ GD IL + G  ++  T  EA + +   P   +++++RR
Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%)

Query: 1070 GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 1125
            GD     +GQ V      E +  L+     L+ + L + D    G+    + K  G  LG
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112

Query: 1126 FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
             S+ GGA        D  ++ I + +V P G A ++G ++ G  +L +N +SL G TH +
Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 1217
            A+ +LR          V   LT        +STD+A   S
Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 214  ISNIVLMKGQAKGLGFSIVGGKDSIYG------PIGIYVKTIFAGGAAAADGRLQEGDEI 267
            +  + + K   + LG SI GG     G        GI++  +   GAA  DGRL+ G  +
Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRL 1157

Query: 268  LELNGESMAGLTHQDALQKFKQAKKGLLTL 297
            LE+N +S+ GLTH +A+Q  +     L  L
Sbjct: 1158 LEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%)

Query: 1215 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 1270
            S   A+++ +E +  E    T+T+ + + GLG S+ GGKGS      D+ + I+R+ +  
Sbjct: 708  SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767

Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 1300
             + ++  V+ GD++L++ G A+QG    EA
Sbjct: 768  PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 70/246 (28%), Positives = 106/246 (43%), Gaps = 14/246 (5%)

Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
           I  I L+KG  KGLGFSI GG     I G   IYV  I  GGAA  DG+LQ GD++L +N
Sbjct: 317 IMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375

Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325
              +  +TH++A+   K        K    T        APP + +  S P+   +S S+
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435

Query: 326 CITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVH 385
            + +  +S A  SP +                +      GLG  +      +   GIF+ 
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG---GEDGEGIFIS 492

Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445
            +  G  A L G LR GD I+ ++   +   +  +    L +   G    IV+++   + 
Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEY 550

Query: 446 SEQQLK 451
           S  + K
Sbjct: 551 SRFEAK 556



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++   G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 232  SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A    +  +  RK   E + ++                              L
Sbjct: 292  AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD++L +    ++ +
Sbjct: 323  IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382

Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
            T  EA   +K   D     V +  S+   +  A  D
Sbjct: 383  THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)

Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           I L +G + GLGFSI GG D+  I     I++  I  GGAAA DGRL+  D IL +N   
Sbjct: 225 ITLERGNS-GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           +  +TH  A++  K+A   ++ L V+ R                                
Sbjct: 284 VRDVTHSKAVEALKEA-GSIVRLYVKRR-------------------------------- 310

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                       KP    ++E+ L K    GLG  +      Q I G   I+V  +  G 
Sbjct: 311 ------------KPVSEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
            AH DG+L+ GD+++ +++  +  +T  E  T L +
Sbjct: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKN 393



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+  TH +A
Sbjct: 328  GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 1179 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 1215
            +  L+   +     +  +   P +M        PD+ +S+                + AS
Sbjct: 388  VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443

Query: 1216 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 1271
             +  S VS     +  +      V L + S GLGF++ GG+      + + I+ I  G  
Sbjct: 444  PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499

Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            ++ S  ++ GD I+ +    ++  +  +A   +K
Sbjct: 500  ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            +LH+    GLGF++ GG D E   I +  +   G A   G ++KG+ ++S+N   L+  +
Sbjct: 468  VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A A L+ A    QAV +  +  PE
Sbjct: 525  HEQAAAALKNA---GQAVTIVAQYRPE 548



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%)

Query: 1188 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 1247
            P +  ++   +     P +  +TDS  + +  +    +   E     +TLE+ ++GLGFS
Sbjct: 182  PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237

Query: 1248 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            + GG  + H   D  + I +I  G A+ Q   ++  D IL++    ++ +T  +A   +K
Sbjct: 238  IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297

Query: 1306 ALPDGPVTIVIRRKSLQSK 1324
                     V RRK +  K
Sbjct: 298  EAGSIVRLYVKRRKPVSEK 316



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E++L++  +G+G  I G    P+    S IF+  +  G  A  DGRLR  D I+ +++  
Sbjct: 224 EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283

Query: 413 VHCLT 417
           V  +T
Sbjct: 284 VRDVT 288


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 70/246 (28%), Positives = 106/246 (43%), Gaps = 14/246 (5%)

Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
           I  I L+KG  KGLGFSI GG     I G   IYV  I  GGAA  DG+LQ GD++L +N
Sbjct: 317 IMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375

Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325
              +  +TH++A+   K        K    T        APP + +  S P+   +S S+
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435

Query: 326 CITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVH 385
            + +  +S A  SP +                +      GLG  +      +   GIF+ 
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG---GEDGEGIFIS 492

Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445
            +  G  A L G LR GD I+ ++   +   +  +    L +   G    IV+++   + 
Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEY 550

Query: 446 SEQQLK 451
           S  + K
Sbjct: 551 SRFEAK 556



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++   G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 232  SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A    +  +  RK   E + ++                              L
Sbjct: 292  AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD++L +    ++ +
Sbjct: 323  IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382

Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
            T  EA   +K   D     V +  S+   +  A  D
Sbjct: 383  THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)

Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           I L +G + GLGFSI GG D+  I     I++  I  GGAAA DGRL+  D IL +N   
Sbjct: 225 ITLERGNS-GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           +  +TH  A++  K+A   ++ L V+ R                                
Sbjct: 284 VRDVTHSKAVEALKEA-GSIVRLYVKRR-------------------------------- 310

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                       KP    ++E+ L K    GLG  +      Q I G   I+V  +  G 
Sbjct: 311 ------------KPVSEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
            AH DG+L+ GD+++ +++  +  +T  E  T L +
Sbjct: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKN 393



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+  TH +A
Sbjct: 328  GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 1179 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 1215
            +  L+   +     +  +   P +M        PD+ +S+                + AS
Sbjct: 388  VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443

Query: 1216 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 1271
             +  S VS     +  +      V L + S GLGF++ GG+      + + I+ I  G  
Sbjct: 444  PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499

Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            ++ S  ++ GD I+ +    ++  +  +A   +K
Sbjct: 500  ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            +LH+    GLGF++ GG D E   I +  +   G A   G ++KG+ ++S+N   L+  +
Sbjct: 468  VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A A L+ A    QAV +  +  PE
Sbjct: 525  HEQAAAALKNA---GQAVTIVAQYRPE 548



 Score = 44.7 bits (104), Expect = 6e-04
 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%)

Query: 1188 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 1247
            P +  ++   +     P +  +TDS  + +  +    +   E     +TLE+ ++GLGFS
Sbjct: 182  PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237

Query: 1248 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            + GG  + H   D  + I +I  G A+ Q   ++  D IL++    ++ +T  +A   +K
Sbjct: 238  IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297

Query: 1306 ALPDGPVTIVIRRKSLQSK 1324
                     V RRK +  K
Sbjct: 298  EAGSIVRLYVKRRKPVSEK 316



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E++L++  +G+G  I G    P+    S IF+  +  G  A  DGRLR  D I+ +++  
Sbjct: 224 EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283

Query: 413 VHCLT 417
           V  +T
Sbjct: 284 VRDVT 288


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 75/233 (32%), Positives = 101/233 (43%), Gaps = 41/233 (17%)

Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
           +  I L KG  KGLGFSI GG     I G   IYV  I  GGAA  DGRLQ GD +L +N
Sbjct: 140 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198

Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325
             S+  +TH++A+   K        K G  T    T    PP +    SPP+   L S  
Sbjct: 199 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 258

Query: 326 CITKD-SSSFALESPS--API------------------STAKPNYRIMVEVSLQKE--- 361
             T +  +S    SP   +PI                  +T +P+  +   VSL+ E   
Sbjct: 259 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRK 318

Query: 362 -----AGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
                   GLG  +      +   GIFV  +  G  A L G L+ GD+I+ ++
Sbjct: 319 VVLHKGSTGLGFNIVG---GEDGEGIFVSFILAGGPADLSGELQRGDQILSVN 368



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++ P G A+++G ++  + +L +N   +   +H  
Sbjct: 55   SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 114

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A        + R       P L                        TV  + L
Sbjct: 115  AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 145

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I  G A+++   +Q GD +L +   +++ +
Sbjct: 146  FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205

Query: 1296 TRFEAWNIIK 1305
            T  EA  I+K
Sbjct: 206  THEEAVAILK 215



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)

Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           I L +G + GLGFSI GG D+  I    GI++  I  GGAAA DGRL+  D IL +N   
Sbjct: 48  ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           ++ ++H  A++  K+A   ++ L VR R                                
Sbjct: 107 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 133

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                       +P    +VE+ L K    GLG  +      Q I G   I+V  +  G 
Sbjct: 134 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
            A  DGRL+ GD ++ +++  +  +T  E   IL +
Sbjct: 181 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%)

Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244
           TS    S +T Q   PS  LQ +V        +VL KG   GLGF+IVGG+D      GI
Sbjct: 290 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 341

Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
           +V  I AGG A   G LQ GD+IL +NG  + G +H+ A    K A
Sbjct: 342 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 56/239 (23%), Positives = 98/239 (41%), Gaps = 60/239 (25%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+ +L +N  SL+  TH +A
Sbjct: 151  GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210

Query: 1179 LAILRQARE----------------PRQAVIVTRKLTP-----------------EAMPD 1205
            +AIL+   E                P     +T   +P                  ++P 
Sbjct: 211  VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP 270

Query: 1206 L-------------------NSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGF 1246
            +                   + S  S A+   +  +    + E     V L K S GLGF
Sbjct: 271  ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF 330

Query: 1247 SLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            ++ GG+      + + ++ I  G  ++ S  +Q GD+IL + G  ++G +  +A   +K
Sbjct: 331  NIVGGEDG----EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            +LHK    GLGF++ GG D E   I V  +   G A   G +Q+G+++LS+NG  L+G +
Sbjct: 320  VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A A L+ A    Q V +  +  PE
Sbjct: 377  HEQAAAALKGA---GQTVTIIAQYQPE 400



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
            +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ +   ++  D IL++    +
Sbjct: 48   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107

Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
              ++  +A   +K      V + +RR+
Sbjct: 108  SEVSHSKAVEALKE-AGSIVRLYVRRR 133



 Score = 35.0 bits (79), Expect = 0.48
 Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 3/81 (3%)

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSV 392
           A++    P++  +  Y    E++L++  +G+G  I G    P+     GIF+  + PG  
Sbjct: 28  AMQHAFIPVNGTEIEYEFE-EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGA 86

Query: 393 AHLDGRLRCGDEIVEISDSPV 413
           A  DGRLR  D I+ +++  V
Sbjct: 87  AAEDGRLRVNDCILRVNEVDV 107


>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
          Length = 1066

 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 38/277 (13%)

Query: 205 PSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-----YGPIGIYVKTIFAGGAAAADG 259
           P GG      S  +++   +  LGF+I+GG+ S+         GI+V  I   G AA +G
Sbjct: 237 PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296

Query: 260 RLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL----LTLTVRTRLTAPPSLCSHLSP 315
            LQ  D I+E+NG  ++  TH  A++ FK AK+ +    L  T RT++  PPS    +  
Sbjct: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT 356

Query: 316 -----------PLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRI------------ 352
                           +SS +    D      E PSA      PN  I            
Sbjct: 357 GTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAH-EYYDPNDYIGDIHQEMDREEL 415

Query: 353 -MVEVSLQK-EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISD 410
            + EV L +  +   LG+ +C     +   GI++  + P S+A  DGR+R GD I++I+ 
Sbjct: 416 ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475

Query: 411 SPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
             V      E   +L+  +     ++++R P+ Q+ E
Sbjct: 476 IEVQ--NREEAVALLTSEENKNFSLLIAR-PELQLDE 509



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 10/118 (8%)

Query: 1115 ILHKEEGAGLGFSLAGGADL-------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
            +LH++ G+ LGF++ GG           ++ I V ++  +G A++EG +Q  + ++ +NG
Sbjct: 251  VLHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309

Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
            + L   TH  A+   + A+EP   V+   + TP        S          +D++ E
Sbjct: 310  RDLSRATHDQAVEAFKTAKEP--IVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFE 365



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 18/74 (24%), Positives = 42/74 (56%), Gaps = 3/74 (4%)

Query: 1124 LGFSLAGGADLENKV-ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAIL 1182
            LG ++    D E+ + I +  + PN +A+++G I++G+ ++ ING  ++     +A+A+L
Sbjct: 431  LGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING--IEVQNREEAVALL 488

Query: 1183 RQAREPRQAVIVTR 1196
                    ++++ R
Sbjct: 489  TSEENKNFSLLIAR 502



 Score = 34.3 bits (77), Expect = 0.82
 Identities = 23/109 (21%), Positives = 51/109 (46%), Gaps = 6/109 (5%)

Query: 1229 EATVCTVTLEKMSAGLGFSLEGGKGSL-----HGDKPLTINRIFKGAASEQSETVQPGDE 1283
            E    T+ L + S  LGF++ GG+ S+        + + +++I     + +   +Q  D 
Sbjct: 244  ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303

Query: 1284 ILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
            I+++ G  +   T  +A    K   + P+ + + R++ ++K  T   +S
Sbjct: 304  IIEVNGRDLSRATHDQAVEAFKTAKE-PIVVQVLRRTPRTKMFTPPSES 351


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 22/215 (10%)

Query: 211 ASVISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEIL 268
           A  +  I L+KG  KGLGFSI GG     I G   IYV  I  GGAA  DGRLQ GD+IL
Sbjct: 198 AEKVMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256

Query: 269 ELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
            +N   +  + H+DA+   K        K    +    +   APP + +  S  L   +S
Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 316

Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKE--------AGVGLGIGLCSVP 374
            S+ +  D  +    +P++P   +     ++ E  + +E           GLG  +    
Sbjct: 317 HSSYLGTDYPT--AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG-- 372

Query: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
             +   GIF+  +  G  A L G LR GD+I+ ++
Sbjct: 373 -GEDGEGIFISFILAGGPADLSGELRKGDQILSVN 406



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++ P G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 116  SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A    +  ++ RK   E                              V  + L
Sbjct: 176  AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 206

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD+IL +    ++ +
Sbjct: 207  IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 266

Query: 1296 TRFEAWNIIK 1305
               +A   +K
Sbjct: 267  MHEDAVAALK 276



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+   H DA
Sbjct: 212  GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 1179 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 1218
            +A L+        +  +P  A +      P+     +   D+  S S+            
Sbjct: 272  VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 331

Query: 1219 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
                     A D+  E         + + + S GLGF++ GG+      + + I+ I  G
Sbjct: 332  TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 387

Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
              ++ S  ++ GD+IL + G  ++  +  +A   +K      VTI+ + K
Sbjct: 388  GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 436



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 71/259 (27%), Positives = 105/259 (40%), Gaps = 64/259 (24%)

Query: 168 SLCSNRKSLSQQLDCPAGKAAGTSRPTRS------LSTAQLVQPSGGLQAS------VIS 215
           SL  ++K   Q  D P  + +    P ++      ++T  L  P   LQ +         
Sbjct: 48  SLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYE 107

Query: 216 NIVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
            I L +G + GLGFSI GG D+  I     I++  I  GGAAA DGRL+  D IL +N  
Sbjct: 108 EITLERGNS-GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166

Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333
            +  +TH  A++  K+A   ++ L V  R                               
Sbjct: 167 DVREVTHSAAVEALKEA-GSIVRLYVMRR------------------------------- 194

Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPG 390
                        KP    ++E+ L K    GLG  +      Q I G   I+V  +  G
Sbjct: 195 -------------KPPAEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 240

Query: 391 SVAHLDGRLRCGDEIVEIS 409
             AH DGRL+ GD+I+ ++
Sbjct: 241 GAAHKDGRLQIGDKILAVN 259



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 5/74 (6%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
           IV+ +G   GLGF+IVGG+D      GI++  I AGG A   G L++GD+IL +NG  + 
Sbjct: 357 IVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411

Query: 277 GLTHQDALQKFKQA 290
             +H+ A    K A
Sbjct: 412 NASHEQAAIALKNA 425



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            ++H+    GLGF++ GG D E   I +  +   G A   G ++KG+++LS+NG  L+  +
Sbjct: 358  VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 414

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A   L+ A    Q V +  +  PE
Sbjct: 415  HEQAAIALKNA---GQTVTIIAQYKPE 438



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
            +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ Q   ++  D IL +    +
Sbjct: 109  ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168

Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
            + +T   A   +K         V+RRK
Sbjct: 169  REVTHSAAVEALKEAGSIVRLYVMRRK 195



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E++L++  +G+G  I G    P+      IF+  + PG  A  DGRLR  D I+ +++  
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167

Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
           V  +T +     L       V + V R   P     ++K
Sbjct: 168 VREVTHSAAVEALKEAG-SIVRLYVMRRKPPAEKVMEIK 205


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 22/215 (10%)

Query: 211 ASVISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEIL 268
           A  +  I L+KG  KGLGFSI GG     I G   IYV  I  GGAA  DGRLQ GD+IL
Sbjct: 152 AEKVMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210

Query: 269 ELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
            +N   +  + H+DA+   K        K    +    +   APP + +  S  L   +S
Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 270

Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKE--------AGVGLGIGLCSVP 374
            S+ +  D  +    +P++P   +     ++ E  + +E           GLG  +    
Sbjct: 271 HSSYLGTDYPT--AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG-- 326

Query: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
             +   GIF+  +  G  A L G LR GD+I+ ++
Sbjct: 327 -GEDGEGIFISFILAGGPADLSGELRKGDQILSVN 360



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++ P G A+Q+G ++  + +L +N   ++  TH  
Sbjct: 70   SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A    +  ++ RK   E                              V  + L
Sbjct: 130  AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 160

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I +G A+ +   +Q GD+IL +    ++ +
Sbjct: 161  IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 220

Query: 1296 TRFEAWNIIK 1305
               +A   +K
Sbjct: 221  MHEDAVAALK 230



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+++L++N   L+   H DA
Sbjct: 166  GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225

Query: 1179 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 1218
            +A L+        +  +P  A +      P+     +   D+  S S+            
Sbjct: 226  VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 285

Query: 1219 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
                     A D+  E         + + + S GLGF++ GG+      + + I+ I  G
Sbjct: 286  TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 341

Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
              ++ S  ++ GD+IL + G  ++  +  +A   +K      VTI+ + K
Sbjct: 342  GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 390



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 59/198 (29%), Positives = 84/198 (42%), Gaps = 52/198 (26%)

Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           I L +G + GLGFSI GG D+  I     I++  I  GGAAA DGRL+  D IL +N   
Sbjct: 63  ITLERGNS-GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           +  +TH  A++  K+A   ++ L V  R                                
Sbjct: 122 VREVTHSAAVEALKEA-GSIVRLYVMRR-------------------------------- 148

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                       KP    ++E+ L K    GLG  +      Q I G   I+V  +  G 
Sbjct: 149 ------------KPPAEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 195

Query: 392 VAHLDGRLRCGDEIVEIS 409
            AH DGRL+ GD+I+ ++
Sbjct: 196 AAHKDGRLQIGDKILAVN 213



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 5/74 (6%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
           IV+ +G   GLGF+IVGG+D      GI++  I AGG A   G L++GD+IL +NG  + 
Sbjct: 311 IVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365

Query: 277 GLTHQDALQKFKQA 290
             +H+ A    K A
Sbjct: 366 NASHEQAAIALKNA 379



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            ++H+    GLGF++ GG D E   I +  +   G A   G ++KG+++LS+NG  L+  +
Sbjct: 312  VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A   L+ A    Q V +  +  PE
Sbjct: 369  HEQAAIALKNA---GQTVTIIAQYKPE 392



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
            +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ Q   ++  D IL +    +
Sbjct: 63   ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122

Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
            + +T   A   +K         V+RRK
Sbjct: 123  REVTHSAAVEALKEAGSIVRLYVMRRK 149



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E++L++  +G+G  I G    P+      IF+  + PG  A  DGRLR  D I+ +++  
Sbjct: 62  EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121

Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
           V  +T +     L       V + V R   P     ++K
Sbjct: 122 VREVTHSAAVEALKEAG-SIVRLYVMRRKPPAEKVMEIK 159


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 71/235 (30%), Positives = 105/235 (44%), Gaps = 23/235 (9%)

Query: 183 PAGK--AAGTSRPTRSLSTAQLVQPSGGLQASVIS---NIVLMKGQAKGLGFSIVGGKDS 237
           P+GK  +A  S P    ST      S G     I    NI L KG  +GLGFSI     +
Sbjct: 427 PSGKPPSAPASAPQNVFSTTV----SSGYNTKKIGKRLNIQLKKG-TEGLGFSITSRDVT 481

Query: 238 IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAK-KGLLT 296
           I G   IYVK I   GAA  DGRL+ GD ++E+NG  + G + ++ +   +  K +G ++
Sbjct: 482 IGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVS 541

Query: 297 LTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEV 356
           L V  +  A         P    +  S   I K++ +   +    P  T +    +  EV
Sbjct: 542 LLVFRQEDA-------FHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTRE---FLTFEV 591

Query: 357 SLQKEAGVGLGIGLCS--VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
            L      GLG+ +            GIFV ++  G  A  DGRLR  D+++ ++
Sbjct: 592 PLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVN 646



 Score = 70.9 bits (172), Expect = 8e-12
 Identities = 41/122 (33%), Positives = 70/122 (57%), Gaps = 7/122 (5%)

Query: 202 LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-YGPIGIYVKTIFAGGAAAADGR 260
           +V    G +  +   + L    + GLG S+ G +    +  +GI+VK+I  GGAA+ DGR
Sbjct: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635

Query: 261 LQEGDEILELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLS 314
           L+  D+++ +NGES+ G T+QDA++  +++      K+G++ L V  R++    L S  S
Sbjct: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695

Query: 315 PP 316
           PP
Sbjct: 696 PP 697



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 57/242 (23%), Positives = 110/242 (45%), Gaps = 25/242 (10%)

Query: 1110 GIHVTILHKEEGAGLGFSLA------GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
            G  + I  K+   GLGFS+       GG+      I V  + P G A Q+G ++ G+ ++
Sbjct: 457  GKRLNIQLKKGTEGLGFSITSRDVTIGGS----APIYVKNILPRGAAIQDGRLKAGDRLI 512

Query: 1164 SINGKSLKGTTHHDALAILRQAR-EPRQAVIVTRKLTPEAMPDLNS--STDSAASASAAS 1220
             +NG  L G +  + +++LR  + E   +++V R+       +LN+  S       + A 
Sbjct: 513  EVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAE 572

Query: 1221 DVSVESTAEATVCTVTLE-----KMSAGLGFSLEGGKG-SLHGDKPLTINRIFKGAASEQ 1274
            D  +  T + T   +T E       SAGLG S++G +    H D  + +  I  G A+ +
Sbjct: 573  DEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASK 632

Query: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------GPVTIVIRRKSLQSKETTA 1328
               ++  D+++ + G ++ G T  +A   ++          G + +++ R+  +  E  +
Sbjct: 633  DGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692

Query: 1329 AG 1330
             G
Sbjct: 693  PG 694



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 31/99 (31%), Positives = 52/99 (52%), Gaps = 8/99 (8%)

Query: 1095 EEVKVLDEATLKQLDGIHVTI-----LHKEEGAGLGFSLAGGADLENKV---ITVHRVFP 1146
            +E K  DE  +   DG    +     L+    AGLG S+ G    EN     I V  +  
Sbjct: 567  KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIIN 626

Query: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185
             G AS++G ++  ++++++NG+SL G T+ DA+  LR++
Sbjct: 627  GGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 61/272 (22%), Positives = 101/272 (37%), Gaps = 71/272 (26%)

Query: 229 FSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFK 288
           FS  GG+      +G+ VK +  GG A  +   +E D I+ +N   +     + A   F+
Sbjct: 291 FSARGGRT-----LGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFR 345

Query: 289 QAKK------------------------------------------------GLLTLTVR 300
           QA +                                                GL T+   
Sbjct: 346 QAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRA 405

Query: 301 TRLTAPP------SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMV 354
            RL  PP      S   H + P  +  S+     ++  S  +   S+  +T K   R+ +
Sbjct: 406 PRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTV---SSGYNTKKIGKRLNI 462

Query: 355 EVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVAHLDGRLRCGDEIVEISDS 411
           ++   K+   GLG  + S      I G   I+V  + P   A  DGRL+ GD ++E++  
Sbjct: 463 QL---KKGTEGLGFSITSRDV--TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517

Query: 412 PVHCLTLNEVYTIL-SHCDPGPVPIIVSRHPD 442
            +   +  EV ++L S    G V ++V R  D
Sbjct: 518 DLVGKSQEEVVSLLRSTKMEGTVSLLVFRQED 549


>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
          Length = 1076

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 84/322 (26%), Positives = 140/322 (43%), Gaps = 46/322 (14%)

Query: 1006 PSSISCAQTPCIPKE--GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTE 1063
            P      +   IP+E  G++      ++    G   +  +D      +S LR+   G   
Sbjct: 33   PDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQ---GGIA 89

Query: 1064 AKED--DDGDHSSLQSG--------QSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHV 1113
            A+ D  D GD+    +G          +ISLL +   + ++E    L   +++    I  
Sbjct: 90   ARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFR 149

Query: 1114 TI---LHKEEGAGLGFSLAGGA-DLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSING 1167
            T+   LHKE G   GF + GGA D  NK   + +  V P G A +EGTI+ G+ +LS++G
Sbjct: 150  TVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208

Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVEST 1227
              L GTTH +A++IL+Q  +   A+++   +         S  DS A+AS    V V  T
Sbjct: 209  IRLLGTTHAEAMSILKQCGQ-EAALLIEYDV---------SVMDSVATASGPLLVEVAKT 258

Query: 1228 AEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQL 1287
              A++       M                  + + I++I   + +++   +  GD IL +
Sbjct: 259  PGASLGVALTTSMCC--------------NKQVIVIDKIKSASIADRCGALHVGDHILSI 304

Query: 1288 GGTAMQGLTRFEAWNIIKALPD 1309
             GT+M+  T  EA   +    D
Sbjct: 305  DGTSMEYCTLAEATQFLANTTD 326



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 31/230 (13%)

Query: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
            ++  G  V  L K+EG  LG +++GG D + K   V  +   G+A++   +  G+ + ++
Sbjct: 46   EEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLDVGDYIKAV 104

Query: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
            NG +L    H + +++L+   E R  + V  +L P                     VSV+
Sbjct: 105  NGINLAKFRHDEIISLLKNVGE-RVVLEVEYELPP---------------------VSVQ 142

Query: 1226 -STAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDK----PLTINRIFKGAASEQSETVQP 1280
             S+       VTL K     GF + GG    H D+    P+ I  +  G  +++  T++P
Sbjct: 143  GSSVIFRTVEVTLHKEGNTFGFVIRGGA---HDDRNKSRPVVITCVRPGGPADREGTIKP 199

Query: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330
            GD +L + G  + G T  EA +I+K        ++    S+     TA+G
Sbjct: 200  GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 49/244 (20%), Positives = 111/244 (45%), Gaps = 37/244 (15%)

Query: 1088 EELKKLIEEVKVLDEATLK----------QLDGIHVTILHKEEGAGLGFSLAGGADLE-N 1136
            EE  +L+ +  +  + TL+             G     L K+    LG +++  +  +  
Sbjct: 486  EEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPG 545

Query: 1137 KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR 1196
              + +  +    +A + GT++ G+++L+I+   L   +  DA+ IL+Q  +     +V  
Sbjct: 546  DPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-----LVKL 600

Query: 1197 KLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLH 1256
            K+      D ++S +  +S              A + TV L++    LG ++ G +    
Sbjct: 601  KIRK----DEDNSDEQESSG-------------AIIYTVELKRYGGPLGITISGTEEPFD 643

Query: 1257 GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316
               P+ I+ + KG  +E++  +  GD IL +  ++++G    EA ++++ +    VT+ I
Sbjct: 644  ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ-MAGETVTLKI 699

Query: 1317 RRKS 1320
            ++++
Sbjct: 700  KKQT 703



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 69/322 (21%), Positives = 120/322 (37%), Gaps = 54/322 (16%)

Query: 154 MTKKSAAPTDRQPYSLCS-NRKSLSQQLDCPAGKAAGTSRPTRSL---STAQLVQPSGGL 209
           +   S +PT    YSL S N  +L + L   + +     R  +     S+  L   + GL
Sbjct: 350 LVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGL 409

Query: 210 QASVI----SNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFAGGAAAADGRLQ 262
              V+    + +VL      G G  + G     +++  P    +  I A   A   G LQ
Sbjct: 410 AGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPP--LISYIEADSPAERCGVLQ 467

Query: 263 EGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
            GD ++ +NG      T ++A Q  + +     ++T +  L     +   + P      S
Sbjct: 468 IGDRVMAINGIPTEDSTFEEASQLLRDS-----SITSKVTLEIEFDVAESVIP------S 516

Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGI 382
           S T                              V L K+  V LGI + S    +    +
Sbjct: 517 SGT----------------------------FHVKLPKKHNVELGITISSPSSRKPGDPL 548

Query: 383 FVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD 442
            +  +  GSVAH  G L  GD+++ I +  +   ++ +   IL  C+   +  +  R  +
Sbjct: 549 VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE--DLVKLKIRKDE 606

Query: 443 PQVSEQQLKEAVAQAVENTKFG 464
               EQ+   A+   VE  ++G
Sbjct: 607 DNSDEQESSGAIIYTVELKRYG 628



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 24/181 (13%)

Query: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209
            A + G +Q G+ V++ING   + +T  +A  +LR +        +T K+T E   D+   
Sbjct: 460  AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-------ITSKVTLEIEFDV--- 509

Query: 1210 TDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
             +S   +S    V +             +K +  LG ++        GD PL I+ I KG
Sbjct: 510  AESVIPSSGTFHVKLP------------KKHNVELGITISSPSSRKPGD-PLVISDIKKG 556

Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329
            + + ++ T++ GD++L +    +   +  +A  I++   D  V + IR+    S E  ++
Sbjct: 557  SVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-LVKLKIRKDEDNSDEQESS 615

Query: 1330 G 1330
            G
Sbjct: 616  G 616



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 10/153 (6%)

Query: 1071 DHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG-IHVTILHKEEGAGLGFSLA 1129
            D+ S++    ++     E+L KL +  K  D +  ++  G I  T+  K  G  LG +++
Sbjct: 580  DNCSMEDAVQILQ--QCEDLVKL-KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITIS 636

Query: 1130 GGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPR 1189
            G  +  + +I +  +   GLA + G I  G+ +L+IN  SLKG    +A+ +L+ A E  
Sbjct: 637  GTEEPFDPII-ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-- 693

Query: 1190 QAVIVTRKLTPEAMPDLNSSTDSAASASAASDV 1222
                VT K+  +      SS      +S  SD+
Sbjct: 694  ---TVTLKIKKQTDAQSASSPKKFPISSHLSDL 723



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)

Query: 1088 EELKKLIE-EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP 1146
            +E   LIE +V V+D  ++    G  +  + K  GA LG +L        +VI + ++  
Sbjct: 228  QEAALLIEYDVSVMD--SVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKS 285

Query: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAM--P 1204
              +A + G +  G+ +LSI+G S++  T  +A   L    +  +  I+    T  A+  P
Sbjct: 286  ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGP 345

Query: 1205 DLNSSTDSAASASAASDVSVESTAEATV 1232
            D  +   S+ S ++ S  S+ S    T+
Sbjct: 346  DHAALVSSSFSPTSMSAYSLSSLNMGTL 373



 Score = 37.7 bits (86), Expect = 0.074
 Identities = 56/243 (23%), Positives = 93/243 (38%), Gaps = 44/243 (18%)

Query: 187 AAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYV 246
           A+ T  P  +L+  +   P     ++V+    LMK +   LG ++ GG D    P    V
Sbjct: 27  ASQTKPPDGALAVRRQSIPEEFKGSTVVE---LMKKEGTTLGLTVSGGIDKDGKP---RV 80

Query: 247 KTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAP 306
             +  GG AA   +L  GD I  +NG ++A   H + +   K   + ++ L V   L   
Sbjct: 81  SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV-LEVEYEL--- 136

Query: 307 PSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGV-G 365
                   PP+  S+  S+ I +                        VEV+L KE    G
Sbjct: 137 --------PPV--SVQGSSVIFR-----------------------TVEVTLHKEGNTFG 163

Query: 366 LGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTIL 425
             I   +         + +  + PG  A  +G ++ GD ++ +    +   T  E  +IL
Sbjct: 164 FVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223

Query: 426 SHC 428
             C
Sbjct: 224 KQC 226



 Score = 35.4 bits (80), Expect = 0.37
 Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 5/115 (4%)

Query: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277
           V +K     LG +I G ++  + PI   + ++  GG A   G +  GD IL +N  S+ G
Sbjct: 622 VELKRYGGPLGITISGTEEP-FDPI--IISSLTKGGLAERTGAIHIGDRILAINSSSLKG 678

Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332
               +A+   + A +  +TL ++ + T   S  S    P+   LS    + +DSS
Sbjct: 679 KPLSEAIHLLQMAGE-TVTLKIK-KQTDAQSASSPKKFPISSHLSDLGDVEEDSS 731


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 78/309 (25%), Positives = 128/309 (41%), Gaps = 21/309 (6%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LGFS+ GG ++     GIYVK+I  GG AA +G++ +GD +L+++G  + GLTH+ A+Q 
Sbjct: 938  LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 997

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
                 + +  L +  R+          S   C S + S    + + S     P  P S  
Sbjct: 998  LTGPGQ-VARLVLERRVPR--------STQQCPSANDSMGDERTAVSLVTALPGRPSSCV 1048

Query: 347  KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----ISGIFVHTLSPGSVAHLDGRLRCG 402
                    EV L+K A  GLG     +    C       + +  L PG  A  +G +  G
Sbjct: 1049 SVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAG 1107

Query: 403  DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTK 462
            D I+ ++      L   EV  +L    P  V +++ R P   + E + +    +   + +
Sbjct: 1108 DIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCRPPPGALPELEQEWQTPELSADKE 1166

Query: 463  FGKERHQWSLEG-VKRLESSWHGRPTLEKE-----REKNSAPPHRRAQKVMIRSSSDSSY 516
            F +     S    +   E SW    + +       R ++S    R AQ    R    +S 
Sbjct: 1167 FTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASS 1226

Query: 517  MSGSPGGSP 525
            ++ SP   P
Sbjct: 1227 LTHSPESHP 1235



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%)

Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
            I+   L KE+G  LGFS+ GG +       I V  + P G A++EG I +G+ +L ++G 
Sbjct: 926  IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984

Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 1222
             L G TH  A+  L    +  + V+  R   P +     S+ DS      A  +      
Sbjct: 985  ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1042

Query: 1223 ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
               S  S  +     V L+K + GLGFS   +E    S      + I R+F G  +E++ 
Sbjct: 1043 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1102

Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
             +  GD IL + G + +GL   E  ++++  P   VT+++ R
Sbjct: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1143



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%)

Query: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
            DG    +  K+   GLGFS         + L++ ++ + R+FP   A + G I  G+ +L
Sbjct: 1052 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1111

Query: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206
            ++NG+S +G    + L +LR A  P++  ++  +  P A+P+L
Sbjct: 1112 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1152



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 55/300 (18%)

Query: 214  ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
            I  + L +   +G GF I  G+ S     GI++ +I  GG A     ++ G +IL LN  
Sbjct: 751  IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810

Query: 274  SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI------ 327
            S+ G T   A++  + +   +  +  +++     +     +      +SS+  +      
Sbjct: 811  SLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQG 870

Query: 328  -----TKDSSSFALESPSAPISTAKPNYRIMVE-------------------------VS 357
                 T+D      E   A + +  P  R  +                          V 
Sbjct: 871  SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 930

Query: 358  LQKEAGVGLGIGL-----CSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
            L KE G  LG  +      SVPY     GI+V ++ PG  A  +G++  GD ++++    
Sbjct: 931  LVKEDGT-LGFSVTGGINTSVPY----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVI 985

Query: 413  VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSL 472
            +  LT  +    L+   PG V  +V     P+ S QQ   A      N   G ER   SL
Sbjct: 986  LCGLTHKQAVQCLT--GPGQVARLVLERRVPR-STQQCPSA------NDSMGDERTAVSL 1036



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 1232 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 1290
            +  VTL++    G GF +  G+ S   D  + I+ I  G  +E+++T++PG +IL L   
Sbjct: 751  IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810

Query: 1291 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 1321
            +++G T   A  +I+  PD    I+ + K +
Sbjct: 811  SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 841



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%)

Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            L ++   G GF +  G  +   +  I +  + P G A +  TI+ G ++L++N  SL+G 
Sbjct: 756  LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 815

Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 1216
            T + A+ +++ + +  + +I   K      PD           SSTD        S  S 
Sbjct: 816  TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 875

Query: 1217 SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 1243
            +   D + E    A V                      C  +  ++SAG           
Sbjct: 876  TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 935

Query: 1244 --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301
              LGFS+ GG  +      + +  I  G  + +   +  GD +LQ+ G  + GLT  +A 
Sbjct: 936  GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995

Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
              +         ++ RR    +++  +A DS
Sbjct: 996  QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1026



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 2/90 (2%)

Query: 351 RIMVEVSLQKEAGVGLGIGLCSVPYF-QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
           R +V V+L+++   G G  +    Y  Q   GIF+ ++ PG  A     ++ G +I+ ++
Sbjct: 749 REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 808

Query: 410 DSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
              +   T N    ++ +  P  + +I+S+
Sbjct: 809 HISLEGFTFNMAVRMIQN-SPDNIELIISQ 837


>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
            sapiens]
          Length = 1309

 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 78/309 (25%), Positives = 128/309 (41%), Gaps = 21/309 (6%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LGFS+ GG ++     GIYVK+I  GG AA +G++ +GD +L+++G  + GLTH+ A+Q 
Sbjct: 960  LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 1019

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
                 + +  L +  R+          S   C S + S    + + S     P  P S  
Sbjct: 1020 LTGPGQ-VARLVLERRVPR--------STQQCPSANDSMGDERTAVSLVTALPGRPSSCV 1070

Query: 347  KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----ISGIFVHTLSPGSVAHLDGRLRCG 402
                    EV L+K A  GLG     +    C       + +  L PG  A  +G +  G
Sbjct: 1071 SVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAG 1129

Query: 403  DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTK 462
            D I+ ++      L   EV  +L    P  V +++ R P   + E + +    +   + +
Sbjct: 1130 DIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCRPPPGALPELEQEWQTPELSADKE 1188

Query: 463  FGKERHQWSLEG-VKRLESSWHGRPTLEKE-----REKNSAPPHRRAQKVMIRSSSDSSY 516
            F +     S    +   E SW    + +       R ++S    R AQ    R    +S 
Sbjct: 1189 FTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASS 1248

Query: 517  MSGSPGGSP 525
            ++ SP   P
Sbjct: 1249 LTHSPESHP 1257



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%)

Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
            I+   L KE+G  LGFS+ GG +       I V  + P G A++EG I +G+ +L ++G 
Sbjct: 948  IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 1006

Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 1222
             L G TH  A+  L    +  + V+  R   P +     S+ DS      A  +      
Sbjct: 1007 ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1064

Query: 1223 ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
               S  S  +     V L+K + GLGFS   +E    S      + I R+F G  +E++ 
Sbjct: 1065 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1124

Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
             +  GD IL + G + +GL   E  ++++  P   VT+++ R
Sbjct: 1125 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1165



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%)

Query: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
            DG    +  K+   GLGFS         + L++ ++ + R+FP   A + G I  G+ +L
Sbjct: 1074 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1133

Query: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206
            ++NG+S +G    + L +LR A  P++  ++  +  P A+P+L
Sbjct: 1134 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1174



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 55/300 (18%)

Query: 214  ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
            I  + L +   +G GF I  G+ S     GI++ +I  GG A     ++ G +IL LN  
Sbjct: 773  IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832

Query: 274  SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI------ 327
            S+ G T   A++  + +   +  +  +++     +     +      +SS+  +      
Sbjct: 833  SLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQG 892

Query: 328  -----TKDSSSFALESPSAPISTAKPNYRIMVE-------------------------VS 357
                 T+D      E   A + +  P  R  +                          V 
Sbjct: 893  SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 952

Query: 358  LQKEAGVGLGIGL-----CSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
            L KE G  LG  +      SVPY     GI+V ++ PG  A  +G++  GD ++++    
Sbjct: 953  LVKEDGT-LGFSVTGGINTSVPY----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVI 1007

Query: 413  VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSL 472
            +  LT  +    L+   PG V  +V     P+ S QQ   A      N   G ER   SL
Sbjct: 1008 LCGLTHKQAVQCLT--GPGQVARLVLERRVPR-STQQCPSA------NDSMGDERTAVSL 1058



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%)

Query: 1232 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 1290
            +  VTL++    G GF +  G+ S   D  + I+ I  G  +E+++T++PG +IL L   
Sbjct: 773  IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832

Query: 1291 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 1321
            +++G T   A  +I+  PD    I+ + K +
Sbjct: 833  SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 863



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%)

Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            L ++   G GF +  G  +   +  I +  + P G A +  TI+ G ++L++N  SL+G 
Sbjct: 778  LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 837

Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 1216
            T + A+ +++ + +  + +I   K      PD           SSTD        S  S 
Sbjct: 838  TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 897

Query: 1217 SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 1243
            +   D + E    A V                      C  +  ++SAG           
Sbjct: 898  TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 957

Query: 1244 --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301
              LGFS+ GG  +      + +  I  G  + +   +  GD +LQ+ G  + GLT  +A 
Sbjct: 958  GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 1017

Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
              +         ++ RR    +++  +A DS
Sbjct: 1018 QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1048



 Score = 30.8 bits (68), Expect = 9.1
 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 2/90 (2%)

Query: 351 RIMVEVSLQKEAGVGLGIGLCSVPYF-QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
           R +V V+L+++   G G  +    Y  Q   GIF+ ++ PG  A     ++ G +I+ ++
Sbjct: 771 REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 830

Query: 410 DSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
              +   T N    ++ +  P  + +I+S+
Sbjct: 831 HISLEGFTFNMAVRMIQN-SPDNIELIISQ 859


>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
          Length = 817

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 35/223 (15%)

Query: 1115 ILHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170
            I+ +   +GLGFS+AGG D     ++  I + ++ P G A+ +G +   + VL +N   +
Sbjct: 132  IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 1230
                H  A+  L++A    + V+  R+  PE                             
Sbjct: 192  SEVVHSRAVEALKEAGPVVRLVVRRRQPPPE----------------------------- 222

Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLG 1288
            T+  V L K   GLGFS+ GG G+ H  GD  + I +I +G A+++   +Q GD +L + 
Sbjct: 223  TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282

Query: 1289 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
             T +Q +   EA   +K   D     V +  SL   +  A  D
Sbjct: 283  NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPD 325



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 68/221 (30%), Positives = 96/221 (43%), Gaps = 33/221 (14%)

Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
           I  + L+KG  KGLGFSI GG     I G   IY+  I  GGAA  DGRLQ GD +L +N
Sbjct: 224 IMEVNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282

Query: 272 GESMAGLTHQDALQKFKQ---------AKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
             ++  + H++A+   K          AK G L L     + APP   S  +      +S
Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHL---NDMYAPPDYASTFTALADNHIS 339

Query: 323 SSTCI----TKDSSSFALESPSAPISTAKPNYRIMV----------EVSLQKEAGVGLGI 368
            ++ +      +S       P  P +   P  R M+          ++ L K    GLG 
Sbjct: 340 HNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHK-GSTGLGF 398

Query: 369 GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
            +      +   GIFV  +  G  A L G LR GD I+ ++
Sbjct: 399 NIVG---GEDGEGIFVSFILAGGPADLSGELRRGDRILSVN 436



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 57/200 (28%), Positives = 88/200 (44%), Gaps = 52/200 (26%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPI--GIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           IVL +G + GLGFSI GG D+ + P   GI++  I  GGAAA DGRL   D +L +N   
Sbjct: 132 IVLERGNS-GLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           ++ + H  A++  K+A   ++ L VR R   P ++                         
Sbjct: 191 VSEVVHSRAVEALKEAGP-VVRLVVRRRQPPPETI------------------------- 224

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                              +EV+L K    GLG  +      Q I G   I++  +  G 
Sbjct: 225 -------------------MEVNLLK-GPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGG 264

Query: 392 VAHLDGRLRCGDEIVEISDS 411
            A  DGRL+ GD ++ ++++
Sbjct: 265 AAQKDGRLQIGDRLLAVNNT 284



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 34/74 (45%), Positives = 44/74 (59%), Gaps = 5/74 (6%)

Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
           I+L KG   GLGF+IVGG+D      GI+V  I AGG A   G L+ GD IL +NG ++ 
Sbjct: 387 IILHKGST-GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441

Query: 277 GLTHQDALQKFKQA 290
             TH+ A    K+A
Sbjct: 442 NATHEQAAAALKRA 455



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 49/235 (20%)

Query: 1123 GLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   +    +  I + ++   G A ++G +Q G+ +L++N  +L+   H +A
Sbjct: 235  GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294

Query: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE--------STAEA 1230
            +A L+   +     +   K     + D+ +  D A++ +A +D  +            E+
Sbjct: 295  VASLKNTSD--MVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVES 352

Query: 1231 TVC------------------------------TVTLEKMSAGLGFSLEGGKGSLHGDKP 1260
             V                                + L K S GLGF++ GG+      + 
Sbjct: 353  KVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG----EG 408

Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIV 1315
            + ++ I  G  ++ S  ++ GD IL + G  ++  T  +A   +K      VTIV
Sbjct: 409  IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS-VTIV 462



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            ILHK    GLGF++ GG D E   I V  +   G A   G +++G+ +LS+NG +L+  T
Sbjct: 388  ILHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A A L++A    Q+V +  +  PE
Sbjct: 445  HEQAAAALKRA---GQSVTIVAQYRPE 468



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 2/92 (2%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E+ L++  +G+G  I G    P+     GIF+  + PG  A +DGRL   D ++ +++  
Sbjct: 131 EIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190

Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 444
           V  +  +     L    P    ++  R P P+
Sbjct: 191 VSEVVHSRAVEALKEAGPVVRLVVRRRQPPPE 222


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)

Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110
            +S++ +Y++      + D+  +SS Q  Q+     SS          K    +  K  D 
Sbjct: 1118 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1175

Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
              V +   +    LG S+ GG +  + +  I V  V P G A  +G I KG+ VL++NG 
Sbjct: 1176 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233

Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215
            SL+G TH  A+  LR             Q+   ++ V VT + T   + D N+       
Sbjct: 1234 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1290

Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271
                + V   S   E     V L K S+GLGFS       +        + + ++F G  
Sbjct: 1291 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1350

Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            + +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1351 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LG S+ GG ++     GIYVK +   GAA +DGR+ +GD +L +NG S+ G TH+ A++ 
Sbjct: 1187 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1246

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
             +   +      V   L    S  S    P+     +  C   D ++          +T 
Sbjct: 1247 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1296

Query: 347  KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397
              +Y  +      EV L K +  GLG         +P     S + V  L PG  A   G
Sbjct: 1297 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1355

Query: 398  RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452
            ++  GD I++++ + +  L+  EV + L    P  V +++ R P    P++    L   +
Sbjct: 1356 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1414

Query: 453  AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512
            + AQ + N+   K+  Q S   V++  SS      +  + +K    P RR        S 
Sbjct: 1415 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1468

Query: 513  DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569
            +   ++     S  + S+   +  S+ V  +      P ++E  + ++     PQ+ P  
Sbjct: 1469 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1526

Query: 570  PESRDSHP 577
            PE  DS+P
Sbjct: 1527 PEFEDSNP 1534



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 44/155 (28%), Positives = 82/155 (52%), Gaps = 9/155 (5%)

Query: 217  IVLMKGQAK-GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
            +V +K  AK GLGF I+GG+      +GI++ ++  GG A  DG L+ GD ++ +N  S+
Sbjct: 902  LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961

Query: 276  AGLTHQDALQKFKQAKKGLLTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332
             G++H  A++  + A +  +TL +   + +++  PS   HL+  +   +  S+ + +DS 
Sbjct: 962  EGVSHHAAIEILQNAPED-VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS- 1018

Query: 333  SFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLG 367
              A++S S     ++   R + E S     G+  G
Sbjct: 1019 --AIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1051



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I L+K +   LGF++  G   I    G YV  +     A +DGRL+ GD ++++N   + 
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
             +TH DA+   + A K     TVR  +                                L
Sbjct: 1653 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1678

Query: 337  ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
            E P  P+    P+    + ++  KE    LG  LC   +      +++  ++P SVA ++
Sbjct: 1679 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1731

Query: 397  GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
            G L+  D I  ++      +TL EV   L    P  V +  +R+  P V     K +   
Sbjct: 1732 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1788

Query: 457  AVENTK 462
            A ++TK
Sbjct: 1789 APKSTK 1794



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)

Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            L K+   GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G 
Sbjct: 905  LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964

Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228
            +HH A+ IL+ A E    VI   K     +P       N   +    +S   D +++S++
Sbjct: 965  SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1024

Query: 1229 E 1229
            +
Sbjct: 1025 K 1025



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LGFS+ GG DS+Y  +  Y+  I     AA +G LQ  D I  +NG S  G+T ++  + 
Sbjct: 1702 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1759

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
               +   L+    R  L   PS          RS  S+   TK + S+++ S S P  T 
Sbjct: 1760 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1811

Query: 347  KPNY 350
              ++
Sbjct: 1812 NDSF 1815



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 891  SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 950

Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 951  DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 993



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%)

Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414
           V+L+K+A  GLG  +        +  GIF+ +++PG  A LDG L+ GD ++ ++   + 
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962

Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
            ++ +    IL +  P  V +++S+ P  ++S+
Sbjct: 963 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 993



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1698 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1755 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1789



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1598 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1653

Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1654 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1693

Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1694 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1742

Query: 1287 LGGTAMQGLT 1296
            + G + QG+T
Sbjct: 1743 VNGVSTQGMT 1752



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 21/91 (23%), Positives = 40/91 (43%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294
            V L K    LG S+ GG  +      + +  +    A+E    +  GD +L + G +++G
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237

Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
             T  +A   ++        ++ + +S  SKE
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1268


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)

Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110
            +S++ +Y++      + D+  +SS Q  Q+     SS          K    +  K  D 
Sbjct: 1309 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1366

Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
              V +   +    LG S+ GG +  + +  I V  V P G A  +G I KG+ VL++NG 
Sbjct: 1367 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1424

Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215
            SL+G TH  A+  LR             Q+   ++ V VT + T   + D N+       
Sbjct: 1425 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1481

Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271
                + V   S   E     V L K S+GLGFS       +        + + ++F G  
Sbjct: 1482 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1541

Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            + +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1542 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LG S+ GG ++     GIYVK +   GAA +DGR+ +GD +L +NG S+ G TH+ A++ 
Sbjct: 1378 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1437

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
             +   +      V   L    S  S    P+     +  C   D ++          +T 
Sbjct: 1438 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1487

Query: 347  KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397
              +Y  +      EV L K +  GLG         +P     S + V  L PG  A   G
Sbjct: 1488 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546

Query: 398  RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452
            ++  GD I++++ + +  L+  EV + L    P  V +++ R P    P++    L   +
Sbjct: 1547 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1605

Query: 453  AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512
            + AQ + N+   K+  Q S   V++  SS      +  + +K    P RR        S 
Sbjct: 1606 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1659

Query: 513  DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569
            +   ++     S  + S+   +  S+ V  +      P ++E  + ++     PQ+ P  
Sbjct: 1660 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1717

Query: 570  PESRDSHP 577
            PE  DS+P
Sbjct: 1718 PEFEDSNP 1725



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 26/256 (10%)

Query: 126  LFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPA- 184
            L  K  HQ +RS++ S+              KS A  +R P       +S S  ++ P  
Sbjct: 999  LVGKPSHQMSRSDAESLAGVTKLN-----NSKSVASLNRSPER--RKHESDSSSIEDPGQ 1051

Query: 185  GKAAGTSRPTRSLSTAQLVQPSGGL---QASVISN------IVLMKGQAK-GLGFSIVGG 234
                G +  +   S++Q+      +   + S++S+      +V +K  AK GLGF I+GG
Sbjct: 1052 AYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111

Query: 235  KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL 294
            +      +GI++ ++  GG A  DG L+ GD ++ +N  S+ G++H  A++  + A +  
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPED- 1170

Query: 295  LTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYR 351
            +TL +   + +++  PS   HL+  +   +  S+ + +DS   A++S S     ++   R
Sbjct: 1171 VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS---AIDSSSKDHHWSRGTLR 1226

Query: 352  IMVEVSLQKEAGVGLG 367
             + E S     G+  G
Sbjct: 1227 HISENSFGPSGGLREG 1242



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I L+K +   LGF++  G   I    G YV  +     A +DGRL+ GD ++++N   + 
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
             +TH DA+   + A K     TVR  +                                L
Sbjct: 1844 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1869

Query: 337  ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
            E P  P+    P+    + ++  KE    LG  LC   +      +++  ++P SVA ++
Sbjct: 1870 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1922

Query: 397  GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
            G L+  D I  ++      +TL EV   L    P  V +  +R+  P V     K +   
Sbjct: 1923 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1979

Query: 457  AVENTK 462
            A ++TK
Sbjct: 1980 APKSTK 1985



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)

Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            L K+   GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G 
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155

Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228
            +HH A+ IL+ A E    VI   K     +P       N   +    +S   D +++S++
Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215

Query: 1229 E 1229
            +
Sbjct: 1216 K 1216



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LGFS+ GG DS+Y  +  Y+  I     AA +G LQ  D I  +NG S  G+T ++  + 
Sbjct: 1893 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1950

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
               +   L+    R  L   PS          RS  S+   TK + S+++ S S P  T 
Sbjct: 1951 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2002

Query: 347  KPNY 350
              ++
Sbjct: 2003 NDSF 2006



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%)

Query: 356  VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414
            V+L+K+A  GLG  +        +  GIF+ +++PG  A LDG L+ GD ++ ++   + 
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153

Query: 415  CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
             ++ +    IL +  P  V +++S+ P  ++S+
Sbjct: 1154 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 1184



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1889 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1946 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1980



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1789 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1844

Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1845 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1884

Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1885 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1933

Query: 1287 LGGTAMQGLT 1296
            + G + QG+T
Sbjct: 1934 VNGVSTQGMT 1943



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 21/91 (23%), Positives = 40/91 (43%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294
            V L K    LG S+ GG  +      + +  +    A+E    +  GD +L + G +++G
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428

Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
             T  +A   ++        ++ + +S  SKE
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1459


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)

Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110
            +S++ +Y++      + D+  +SS Q  Q+     SS          K    +  K  D 
Sbjct: 1290 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1347

Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
              V +   +    LG S+ GG +  + +  I V  V P G A  +G I KG+ VL++NG 
Sbjct: 1348 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405

Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215
            SL+G TH  A+  LR             Q+   ++ V VT + T   + D N+       
Sbjct: 1406 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1462

Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271
                + V   S   E     V L K S+GLGFS       +        + + ++F G  
Sbjct: 1463 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1522

Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            + +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1523 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LG S+ GG ++     GIYVK +   GAA +DGR+ +GD +L +NG S+ G TH+ A++ 
Sbjct: 1359 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1418

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
             +   +      V   L    S  S    P+     +  C   D ++          +T 
Sbjct: 1419 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1468

Query: 347  KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397
              +Y  +      EV L K +  GLG         +P     S + V  L PG  A   G
Sbjct: 1469 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1527

Query: 398  RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452
            ++  GD I++++ + +  L+  EV + L    P  V +++ R P    P++    L   +
Sbjct: 1528 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1586

Query: 453  AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512
            + AQ + N+   K+  Q S   V++  SS      +  + +K    P RR        S 
Sbjct: 1587 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1640

Query: 513  DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569
            +   ++     S  + S+   +  S+ V  +      P ++E  + ++     PQ+ P  
Sbjct: 1641 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1698

Query: 570  PESRDSHP 577
            PE  DS+P
Sbjct: 1699 PEFEDSNP 1706



 Score = 58.2 bits (139), Expect = 5e-08
 Identities = 44/155 (28%), Positives = 82/155 (52%), Gaps = 9/155 (5%)

Query: 217  IVLMKGQAK-GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
            +V +K  AK GLGF I+GG+      +GI++ ++  GG A  DG L+ GD ++ +N  S+
Sbjct: 1074 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133

Query: 276  AGLTHQDALQKFKQAKKGLLTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332
             G++H  A++  + A +  +TL +   + +++  PS   HL+  +   +  S+ + +DS 
Sbjct: 1134 EGVSHHAAIEILQNAPED-VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS- 1190

Query: 333  SFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLG 367
              A++S S     ++   R + E S     G+  G
Sbjct: 1191 --AIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1223



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 47/179 (26%), Positives = 84/179 (46%), Gaps = 22/179 (12%)

Query: 1073 SSLQSGQSVISLLSSEELKKL-IEEVKVLDEATLKQLDGIH------------VTILHKE 1119
            + L + +SV SL  S E +K   +   + D      LD +H            +T+++ +
Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078

Query: 1120 EGA--GLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
            + A  GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G +H
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138

Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTAE 1229
            H A+ IL+ A E    VI   K     +P       N   +    +S   D +++S+++
Sbjct: 1139 HAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSK 1197



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I L+K +   LGF++  G   I    G YV  +     A +DGRL+ GD ++++N   + 
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
             +TH DA+   + A K     TVR  +                                L
Sbjct: 1825 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1850

Query: 337  ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
            E P  P+    P+    + ++  KE    LG  LC   +      +++  ++P SVA ++
Sbjct: 1851 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1903

Query: 397  GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
            G L+  D I  ++      +TL EV   L    P  V +  +R+  P V     K +   
Sbjct: 1904 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1960

Query: 457  AVENTK 462
            A ++TK
Sbjct: 1961 APKSTK 1966



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LGFS+ GG DS+Y  +  Y+  I     AA +G LQ  D I  +NG S  G+T ++  + 
Sbjct: 1874 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1931

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
               +   L+    R  L   PS          RS  S+   TK + S+++ S S P  T 
Sbjct: 1932 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1983

Query: 347  KPNY 350
              ++
Sbjct: 1984 NDSF 1987



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 38/149 (25%), Positives = 73/149 (48%), Gaps = 4/149 (2%)

Query: 301  TRLTAPPSLCS-HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQ 359
            T+L    S+ S + SP   +  S S+ I     ++ L+      S      R +  V+L+
Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078

Query: 360  KEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTL 418
            K+A  GLG  +        +  GIF+ +++PG  A LDG L+ GD ++ ++   +  ++ 
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138

Query: 419  NEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
            +    IL +  P  V +++S+ P  ++S+
Sbjct: 1139 HAAIEILQNA-PEDVTLVISQ-PKEKISK 1165



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 1063 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122

Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1165



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1870 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1927 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1961



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1770 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1825

Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1826 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1865

Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1866 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1914

Query: 1287 LGGTAMQGLT 1296
            + G + QG+T
Sbjct: 1915 VNGVSTQGMT 1924



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 21/91 (23%), Positives = 40/91 (43%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294
            V L K    LG S+ GG  +      + +  +    A+E    +  GD +L + G +++G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409

Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
             T  +A   ++        ++ + +S  SKE
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1440


>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
          Length = 145

 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 42/80 (52%), Positives = 52/80 (65%), Gaps = 3/80 (3%)

Query: 226 GLGFSIVGGKDSIY--GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
           GLGF+IVGG D  Y     GIYV  I   GAAA DGRLQEGD+IL +NG+ +  L HQDA
Sbjct: 22  GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81

Query: 284 LQKFKQAKKGLLTLTVRTRL 303
           +  F+ A    ++L V+ RL
Sbjct: 82  VDLFRNAGYA-VSLRVQHRL 100



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 27/68 (39%), Positives = 44/68 (64%), Gaps = 4/68 (5%)

Query: 1122 AGLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGF++ GG D +    +  I V R+  NG A+ +G +Q+G+++LS+NG+ LK   H D
Sbjct: 21   SGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQD 80

Query: 1178 ALAILRQA 1185
            A+ + R A
Sbjct: 81   AVDLFRNA 88



 Score = 32.0 bits (71), Expect = 4.1
 Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
           E++L +  +G+G  I G     Y    SGI+V  +     A LDGRL+ GD+I+ ++
Sbjct: 13  EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVN 69


>gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens]
          Length = 1141

 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 27/194 (13%)

Query: 1119 EEGAGLGFSLAGGADLE---NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
            +EG   GF L GGA  +   ++ + +  V P G A +EG+++ G+ +LS++G  L G +H
Sbjct: 250  KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309

Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTV 1235
              ALA LRQ        +     TP          D+ A+AS    V +  T        
Sbjct: 310  ATALATLRQCSHEALFQVEYDVATP----------DTVANASGPLMVEIVKTP------- 352

Query: 1236 TLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
                  + LG SL     SL     +TI+RI   +  ++S  + PGD IL + GT+M+  
Sbjct: 353  -----GSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405

Query: 1296 TRFEAWNIIKALPD 1309
            +  EA  ++ ++ +
Sbjct: 406  SLLEATKLLASISE 419



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 22/196 (11%)

Query: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
            ++  GI V  L K+EG+ LG +++GG D + K   V  + P GLA++   +  G+ + S+
Sbjct: 138  EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196

Query: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
            NG  L    H + + +L+   E R  + V  +L P A P+ N                + 
Sbjct: 197  NGIHLTRLRHDEIITLLKNVGE-RVVLEVEYELPPPA-PENNPRI-------------IS 241

Query: 1226 STAEATVCTVTLEKMSAGLGFSLEGG-KGSLHGDKPLTINRIFKGAASEQSETVQPGDEI 1284
             T +     V+L K     GF L GG     H  +PL +  +  G  +++  +++ GD +
Sbjct: 242  KTVD-----VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296

Query: 1285 LQLGGTAMQGLTRFEA 1300
            L + G  + G +   A
Sbjct: 297  LSVDGIPLHGASHATA 312



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 28/229 (12%)

Query: 1092 KLIEEVKV-LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLA 1150
            K++ EV+  + E+ +      HV  L K+    LG +++  +    + + +  +    +A
Sbjct: 634  KVVLEVEFDVAESVIPSSGTFHVK-LPKKRSVELGITISSASRKRGEPLIISDIKKGSVA 692

Query: 1151 SQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSST 1210
             + GT++ G+++L+I+   L      DA+ ILRQ  +     +V  K+  +       ++
Sbjct: 693  HRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED-----LVKLKIRKD-----EDNS 742

Query: 1211 DSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGA 1270
            D   +  A S             TV L++    LG ++ G +       P+ I+ + K  
Sbjct: 743  DELETTGAVS------------YTVELKRYGGPLGITISGTEEPF---DPIVISGLTKRG 787

Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
             +E++  +  GD IL +   +++G    EA ++++   +  VT+ I+++
Sbjct: 788  LAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGE-TVTLKIKKQ 835



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%)

Query: 1122 AGLGFSLAGGADLENKVIT---VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            +G G  L GG      + +   V  + P+  A + G +Q G+ VLSING + +  T  +A
Sbjct: 563  SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622

Query: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLE 1238
              +LR A    + V             L    D A S   +S          T      +
Sbjct: 623  NQLLRDAALAHKVV-------------LEVEFDVAESVIPSS---------GTFHVKLPK 660

Query: 1239 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 1298
            K S  LG ++     S    +PL I+ I KG+ + ++ T++PGD++L +    +      
Sbjct: 661  KRSVELGITI--SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718

Query: 1299 EAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330
            +A  I++   D  V + IR+    S E    G
Sbjct: 719  DAVQILRQCED-LVKLKIRKDEDNSDELETTG 749



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 53/275 (19%)

Query: 201 QLVQPSGGLQASVISNIVLMKGQAKGLGFSIV---GGKDSIYGPIGIYVKTIFAGGAAAA 257
           +L  P+      +IS  V +    +G  F  V   G  +  +    + +  +  GG A  
Sbjct: 227 ELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADR 286

Query: 258 DGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPL 317
           +G L+ GD +L ++G  + G +H  AL   +Q                    CSH     
Sbjct: 287 EGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------------------CSH----- 321

Query: 318 CRSLSSSTCITKDSSSFALESPSA-PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYF 376
                         + F +E   A P + A  +  +MVE+   K  G  LGI L +    
Sbjct: 322 -------------EALFQVEYDVATPDTVANASGPLMVEIV--KTPGSALGISLTTTS-L 365

Query: 377 QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV-HCLTLNEVYTILSHCDPGPVPI 435
           +  S I +  + P SV    G L  GD I+ I  + + HC  L     + S  +   + I
Sbjct: 366 RNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425

Query: 436 IVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQW 470
           +    P PQ S++ L+    + V   +  ++ H+W
Sbjct: 426 L----PVPQ-SQRPLRP--QRQVVKVQRSEQLHRW 453



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 25/92 (27%), Positives = 43/92 (46%)

Query: 1096 EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 1155
            E  V    T+    G  +  + K  G+ LG SL   +     VIT+ R+ P  +  + G 
Sbjct: 328  EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGA 387

Query: 1156 IQKGNEVLSINGKSLKGTTHHDALAILRQARE 1187
            +  G+ +LSI+G S++  +  +A  +L    E
Sbjct: 388  LHPGDHILSIDGTSMEHCSLLEATKLLASISE 419



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 63/273 (23%), Positives = 101/273 (36%), Gaps = 48/273 (17%)

Query: 196 SLSTAQ-LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFA 251
           SLS A   V P G +  +  + +VL      G G  + GG    +++  P    V  I  
Sbjct: 533 SLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPP--LVCFIEP 590

Query: 252 GGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCS 311
              A   G LQ GD +L +NG +    T ++A Q  + A      L  +  L     +  
Sbjct: 591 DSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDA-----ALAHKVVLEVEFDVAE 645

Query: 312 HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC 371
            + P      SS T                              V L K+  V LGI + 
Sbjct: 646 SVIP------SSGT----------------------------FHVKLPKKRSVELGITIS 671

Query: 372 SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPG 431
           S    +    + +  +  GSVAH  G L  GD+++ I +  +    + +   IL  C+  
Sbjct: 672 SASRKRG-EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCE-- 728

Query: 432 PVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFG 464
            +  +  R  +    E +   AV+  VE  ++G
Sbjct: 729 DLVKLKIRKDEDNSDELETTGAVSYTVELKRYG 761



 Score = 36.2 bits (82), Expect = 0.22
 Identities = 51/217 (23%), Positives = 78/217 (35%), Gaps = 42/217 (19%)

Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
           I+ + L+K +   LG +I GG D    P    V  +  GG AA    L  GD I  +NG 
Sbjct: 143 ITVVELIKKEGSTLGLTISGGTDKDGKP---RVSNLRPGGLAARSDLLNIGDYIRSVNGI 199

Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333
            +  L H + +   K   + ++ L V   L  P       +P     + S T        
Sbjct: 200 HLTRLRHDEIITLLKNVGERVV-LEVEYELPPP-------APENNPRIISKT-------- 243

Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG--IFVHTLSPGS 391
                               V+VSL KE G   G  L    +        + +  + PG 
Sbjct: 244 --------------------VDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGG 282

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
            A  +G L+ GD ++ +   P+H  +       L  C
Sbjct: 283 PADREGSLKVGDRLLSVDGIPLHGASHATALATLRQC 319


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 59/213 (27%), Positives = 93/213 (43%), Gaps = 28/213 (13%)

Query: 1110 GIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 1169
            GI VT+L  + G        G        I V  V P G A  +G I KG+ VL++NG S
Sbjct: 1379 GISVTVLFDKGGVNTSVRHGG--------IYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1430

Query: 1170 LKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
            L+G TH  A+  LR             Q+   ++ V VT + T   + D N+        
Sbjct: 1431 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEKV 1487

Query: 1217 SAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAAS 1272
               + V   S   E     V L K S+GLGFS       +        + + ++F G  +
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547

Query: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
             +S  +  GD IL++ G +++GL++ E  + ++
Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 91/373 (24%), Positives = 156/373 (41%), Gaps = 42/373 (11%)

Query: 227  LGFSIV-----GGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
            LG S+      GG ++     GIYVK +   GAA +DGR+ +GD +L +NG S+ G TH+
Sbjct: 1378 LGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1437

Query: 282  DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341
             A++  +   +      V   L    S  S    P+     +  C   D ++        
Sbjct: 1438 QAVETLRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKV 1487

Query: 342  PISTAKPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSV 392
              +T   +Y  +      EV L K +  GLG         +P     S + V  L PG  
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1546

Query: 393  AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQ 449
            A   G++  GD I++++ + +  L+  EV + L    P  V +++ R P    P++    
Sbjct: 1547 AAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTAL 1605

Query: 450  LK--EAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVM 507
            L   ++ AQ + N+   K+  Q S   V++  SS      +  + +K    P RR     
Sbjct: 1606 LTPLQSPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSD 1659

Query: 508  IRSSSDSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQ 564
               S +   ++     S  + S+   +  S+ V  +      P ++E  + ++     PQ
Sbjct: 1660 SSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQ 1717

Query: 565  ESPPLPESRDSHP 577
            + P  PE  DS+P
Sbjct: 1718 KIPNKPEFEDSNP 1730



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 26/256 (10%)

Query: 126  LFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPA- 184
            L  K  HQ +RS++ S+              KS A  +R P       +S S  ++ P  
Sbjct: 999  LVGKPSHQMSRSDAESLAGVTKLN-----NSKSVASLNRSPER--RKHESDSSSIEDPGQ 1051

Query: 185  GKAAGTSRPTRSLSTAQLVQPSGGL---QASVISN------IVLMKGQAK-GLGFSIVGG 234
                G +  +   S++Q+      +   + S++S+      +V +K  AK GLGF I+GG
Sbjct: 1052 AYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111

Query: 235  KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL 294
            +      +GI++ ++  GG A  DG L+ GD ++ +N  S+ G++H  A++  + A +  
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPED- 1170

Query: 295  LTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYR 351
            +TL +   + +++  PS   HL+  +   +  S+ + +DS   A++S S     ++   R
Sbjct: 1171 VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS---AIDSSSKDHHWSRGTLR 1226

Query: 352  IMVEVSLQKEAGVGLG 367
             + E S     G+  G
Sbjct: 1227 HISENSFGPSGGLREG 1242



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)

Query: 217  IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
            I L+K +   LGF++  G   I    G YV  +     A +DGRL+ GD ++++N   + 
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848

Query: 277  GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
             +TH DA+   + A K     TVR  +                                L
Sbjct: 1849 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1874

Query: 337  ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
            E P  P+    P+    + ++  KE    LG  LC   +      +++  ++P SVA ++
Sbjct: 1875 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1927

Query: 397  GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
            G L+  D I  ++      +TL EV   L    P  V +  +R+  P V     K +   
Sbjct: 1928 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1984

Query: 457  AVENTK 462
            A ++TK
Sbjct: 1985 APKSTK 1990



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)

Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
            L K+   GLGF + GG  +   +  I +  V P G A  +G ++ G+ ++S+N  SL+G 
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155

Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228
            +HH A+ IL+ A E    VI   K     +P       N   +    +S   D +++S++
Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215

Query: 1229 E 1229
            +
Sbjct: 1216 K 1216



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)

Query: 227  LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
            LGFS+ GG DS+Y  +  Y+  I     AA +G LQ  D I  +NG S  G+T ++  + 
Sbjct: 1898 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1955

Query: 287  FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
               +   L+    R  L   PS          RS  S+   TK + S+++ S S P  T 
Sbjct: 1956 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2007

Query: 347  KPNY 350
              ++
Sbjct: 2008 NDSF 2011



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)

Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
            S+ S+ E  +  V L+K +  GLGF + GG+     D  + I+ +  G  ++    ++PG
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
            D ++ +   +++G++   A  I++  P+    ++ + K   SK
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%)

Query: 356  VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414
            V+L+K+A  GLG  +        +  GIF+ +++PG  A LDG L+ GD ++ ++   + 
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153

Query: 415  CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
             ++ +    IL +  P  V +++S+ P  ++S+
Sbjct: 1154 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 1184



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)

Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
            +KEE   LGFSL GG D   +V+ +  + P  +A+ EG +Q  + +  +NG S +G T  
Sbjct: 1894 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
            +    L  +        +  K T   +P + SS  SA SA
Sbjct: 1951 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1985



 Score = 39.7 bits (91), Expect = 0.020
 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)

Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
            +T++  E+G+ LGF++  G   +     VH V  +  A  +G ++ G+ ++ +N   +  
Sbjct: 1794 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1849

Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
             TH DA+ +LR A +  + VI          + P  +PD+                    
Sbjct: 1850 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1889

Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
                   T+T  K    LGFSL GG  SL+  + + I+ I   + +     +Q  D I  
Sbjct: 1890 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1938

Query: 1287 LGGTAMQGLT 1296
            + G + QG+T
Sbjct: 1939 VNGVSTQGMT 1948


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++ P G A+++G ++  + +L +N   +   +H  
Sbjct: 211  SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 270

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A        + R       P L                        TV  + L
Sbjct: 271  AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 301

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I  G A+++   +Q GD +L +   +++ +
Sbjct: 302  FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 361

Query: 1296 TRFEAWNIIK 1305
            T  EA  I+K
Sbjct: 362  THEEAVAILK 371



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 48/118 (40%), Positives = 58/118 (49%), Gaps = 9/118 (7%)

Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
           +  I L KG  KGLGFSI GG     I G   IYV  I  GGAA  DGRLQ GD +L +N
Sbjct: 296 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354

Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323
             S+  +TH++A+   K        K G  T    T    PP +    SPP+   L S
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 412



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)

Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           I L +G + GLGFSI GG D+  I    GI++  I  GGAAA DGRL+  D IL +N   
Sbjct: 204 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           ++ ++H  A++  K+A   ++ L VR R                                
Sbjct: 263 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 289

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                       +P    +VE+ L K    GLG  +      Q I G   I+V  +  G 
Sbjct: 290 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 336

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
            A  DGRL+ GD ++ +++  +  +T  E   IL +
Sbjct: 337 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 372



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%)

Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244
           TS    S +T Q   PS  LQ +V        +VL KG   GLGF+IVGG+D      GI
Sbjct: 498 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 549

Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
           +V  I AGG A   G LQ GD+IL +NG  + G +H+ A    K A
Sbjct: 550 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            +LHK    GLGF++ GG D E   I V  +   G A   G +Q+G+++LS+NG  L+G +
Sbjct: 528  VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A A L+ A    Q V +  +  PE
Sbjct: 585  HEQAAAALKGA---GQTVTIIAQYQPE 608



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+ +L +N  SL+  TH +A
Sbjct: 307  GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366

Query: 1179 LAILRQARE 1187
            +AIL+   E
Sbjct: 367  VAILKNTSE 375



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
            +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ +   ++  D IL++    +
Sbjct: 204  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263

Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
              ++  +A   +K      V + +RR+
Sbjct: 264  SEVSHSKAVEALKE-AGSIVRLYVRRR 289



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%)

Query: 1209 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268
            S  S A+   +  +    + E     V L K S GLGF++ GG+      + + ++ I  
Sbjct: 501  SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 556

Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            G  ++ S  +Q GD+IL + G  ++G +  +A   +K
Sbjct: 557  GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 2/61 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E++L++  +G+G  I G    P+     GIF+  + PG  A  DGRLR  D I+ +++  
Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262

Query: 413 V 413
           V
Sbjct: 263 V 263


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)

Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
            +GLGFS+AGG D     ++  I + ++ P G A+++G ++  + +L +N   +   +H  
Sbjct: 106  SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 165

Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
            A+  L++A        + R       P L                        TV  + L
Sbjct: 166  AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 196

Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
             K   GLGFS+ GG G+ H  GD  + + +I  G A+++   +Q GD +L +   +++ +
Sbjct: 197  FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 256

Query: 1296 TRFEAWNIIK 1305
            T  EA  I+K
Sbjct: 257  THEEAVAILK 266



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 48/118 (40%), Positives = 58/118 (49%), Gaps = 9/118 (7%)

Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
           +  I L KG  KGLGFSI GG     I G   IYV  I  GGAA  DGRLQ GD +L +N
Sbjct: 191 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249

Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323
             S+  +TH++A+   K        K G  T    T    PP +    SPP+   L S
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 307



 Score = 64.7 bits (156), Expect = 6e-10
 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)

Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
           I L +G + GLGFSI GG D+  I    GI++  I  GGAAA DGRL+  D IL +N   
Sbjct: 99  ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157

Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
           ++ ++H  A++  K+A   ++ L VR R                                
Sbjct: 158 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 184

Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
                       +P    +VE+ L K    GLG  +      Q I G   I+V  +  G 
Sbjct: 185 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 231

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
            A  DGRL+ GD ++ +++  +  +T  E   IL +
Sbjct: 232 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 267



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%)

Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244
           TS    S +T Q   PS  LQ +V        +VL KG   GLGF+IVGG+D      GI
Sbjct: 393 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 444

Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
           +V  I AGG A   G LQ GD+IL +NG  + G +H+ A    K A
Sbjct: 445 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 490



 Score = 54.7 bits (130), Expect = 6e-07
 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)

Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
            +LHK    GLGF++ GG D E   I V  +   G A   G +Q+G+++LS+NG  L+G +
Sbjct: 423  VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479

Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
            H  A A L+ A    Q V +  +  PE
Sbjct: 480  HEQAAAALKGA---GQTVTIIAQYQPE 503



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%)

Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
            GLGFS+AGG   ++      I V ++   G A ++G +Q G+ +L +N  SL+  TH +A
Sbjct: 202  GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261

Query: 1179 LAILRQARE 1187
            +AIL+   E
Sbjct: 262  VAILKNTSE 270



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)

Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
            +TLE+ ++GLGFS+ GG  + H GD P + I +I  G A+ +   ++  D IL++    +
Sbjct: 99   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158

Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
              ++  +A   +K      V + +RR+
Sbjct: 159  SEVSHSKAVEALKE-AGSIVRLYVRRR 184



 Score = 38.5 bits (88), Expect = 0.043
 Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%)

Query: 1209 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268
            S  S A+   +  +    + E     V L K S GLGF++ GG+      + + ++ I  
Sbjct: 396  SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 451

Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
            G  ++ S  +Q GD+IL + G  ++G +  +A   +K
Sbjct: 452  GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 2/61 (3%)

Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
           E++L++  +G+G  I G    P+     GIF+  + PG  A  DGRLR  D I+ +++  
Sbjct: 98  EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157

Query: 413 V 413
           V
Sbjct: 158 V 158


>gi|119120897 par-3 partitioning defective 3 homolog B isoform b
           [Homo sapiens]
          Length = 1143

 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 33/74 (44%), Positives = 46/74 (62%)

Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
           +K   +GLGF++V    SI+GP  I+VK I   GAA  DGRLQ GD ILE+NG  + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 280 HQDALQKFKQAKKG 293
            ++ +   +  K+G
Sbjct: 446 QEELVAMLRSTKQG 459



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)

Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
            DA A L+Q + PR   +  +  +P   P +                   S   A    + 
Sbjct: 342  DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385

Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
            L+K   GLGF++     S+HG  P+ +  I    A+ +   +Q GD IL++ G  + G T
Sbjct: 386  LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445

Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
            + E   ++++   G   ++VI R+
Sbjct: 446  QEELVAMLRSTKQGETASLVIARQ 469



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 19/66 (28%), Positives = 36/66 (54%)

Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
            I V  + P G A ++G +Q G+ +L +NG+ + G T  + +A+LR  ++   A +V  + 
Sbjct: 410  IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469

Query: 1199 TPEAMP 1204
                +P
Sbjct: 470  EGHFLP 475



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 65/286 (22%), Positives = 109/286 (38%), Gaps = 48/286 (16%)

Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
           + T  L  P      S ++  V + G+   LG  +V    S+ G I G++++ I     +
Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242

Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
             +G   E + I+++N   +   T   A   F+QA K     L  L  + R     S+  
Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302

Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
            L+              PP+         +L+ +     D+S+   +  SP  P    KP
Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362

Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
           +   +              +++ L+K      G+G   V     I G   IFV  + P  
Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419

Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437
            A  DGRL+ GD I+E++   V   T  E+  +L     G    +V
Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465



 Score = 31.6 bits (70), Expect = 5.3
 Identities = 10/33 (30%), Positives = 26/33 (78%)

Query: 1153 EGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185
            +G ++  ++++++NG+SL G ++H+A+  LR++
Sbjct: 479  DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 58/218 (26%), Positives = 104/218 (47%), Gaps = 18/218 (8%)

Query: 1113 VTILHKEEGAGLGFSLAGGA-----DLENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
            V  + K+ G  LG ++AGGA     DL   VI+V    P G+ S++G I+ G+ +L+++G
Sbjct: 507  VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE---PGGVISRDGRIKTGDILLNVDG 563

Query: 1168 KSLKGTTHHDALAILRQAREPRQA-VIVTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
              L   +  +A+A+L++         +  ++  P+      ++ DS  + +  SD S   
Sbjct: 564  VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSW 623

Query: 1227 TA--EATVCT-----VTLEKMSAG-LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETV 1278
                E   C      + L + +AG LGF + GG    +G+KP  I  I +G  +     +
Sbjct: 624  VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683

Query: 1279 QPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316
            + GD +L + G +  G+       ++K L  G +T+ I
Sbjct: 684  RCGDILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 720



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 49/196 (25%), Positives = 91/196 (46%), Gaps = 17/196 (8%)

Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGL 278
           + K   + LG ++ GG       + IYV ++  GG  + DGR++ GD +L ++G  +  +
Sbjct: 510 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 569

Query: 279 THQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALES 338
           +  +A+   K+    ++   +  +   P   CS  SP    +L S+  +   S      S
Sbjct: 570 SRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS--SP---AALDSNHNMAPPSD----WS 620

Query: 339 PSAPISTAKPN--YRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVA 393
           PS  +    P   Y     V  +  AG    +G C V  ++  +G    F+ ++  G+ A
Sbjct: 621 PSWVMWLELPRCLYNCKDIVLRRNTAG---SLGFCIVGGYEEYNGNKPFFIKSIVEGTPA 677

Query: 394 HLDGRLRCGDEIVEIS 409
           + DGR+RCGD ++ ++
Sbjct: 678 YNDGRIRCGDILLAVN 693



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 33/84 (39%), Positives = 49/84 (58%), Gaps = 1/84 (1%)

Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
           +IVL +  A  LGF IVGG +   G    ++K+I  G  A  DGR++ GD +L +NG S 
Sbjct: 638 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697

Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299
           +G+ H   L +  +  KG +TLT+
Sbjct: 698 SGMIHA-CLARLLKELKGRITLTI 720



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 49/225 (21%), Positives = 95/225 (42%), Gaps = 11/225 (4%)

Query: 1109 DGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
            D  HV +        LG  L    D     + +  V   G+A + G +++ + VL+ING 
Sbjct: 378  DSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDRVLAINGH 435

Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKL---TPEAMPDLNSSTDSAASASAASDVSVE 1225
             L+  +   A A L QA E R  ++V+R++   +P+   +   +++ + S       +  
Sbjct: 436  DLRYGSPESA-AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP 494

Query: 1226 STAEATVC----TVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQP 1280
                 T+      V ++K     LG ++ GG      D P+ +  +  G    +   ++ 
Sbjct: 495  KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKT 554

Query: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
            GD +L + G  +  ++R EA  ++K      V   +  K  + +E
Sbjct: 555  GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 37/188 (19%), Positives = 80/188 (42%), Gaps = 19/188 (10%)

Query: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302
           G+++  +  GG A   G+L+E D +L +NG  +   + + A    + +++ +  +  R  
Sbjct: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQV 464

Query: 303 LTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMV----EVSL 358
               P +                    +S+      P    +T KP +  +      V++
Sbjct: 465 RQRSPDIFQEAG--------------WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNI 510

Query: 359 QKEAGVGLGIGLC-SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417
           QK+ G  LG+ +     + +    I+V ++ PG V   DGR++ GD ++ +    +  ++
Sbjct: 511 QKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVS 570

Query: 418 LNEVYTIL 425
            +E   +L
Sbjct: 571 RSEAVALL 578



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 25/76 (32%), Positives = 44/76 (57%), Gaps = 3/76 (3%)

Query: 224 AKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
           ++ L   +VGG ++    + I ++ I+  G  A DGRL  GD IL++NG  ++ + H  A
Sbjct: 283 SESLSIRLVGGSETPL--VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340

Query: 284 LQKFKQAKKGLLTLTV 299
           ++  +Q  + +L LTV
Sbjct: 341 VRLLRQPCQ-VLWLTV 355



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 17/72 (23%), Positives = 37/72 (51%)

Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
            + I   +    L   L GG++     I +  ++ +G+ +++G +  G+ +L +NG  +  
Sbjct: 275  IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334

Query: 1173 TTHHDALAILRQ 1184
              H+ A+ +LRQ
Sbjct: 335  VPHNYAVRLLRQ 346


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,596,013
Number of Sequences: 37866
Number of extensions: 3117173
Number of successful extensions: 16242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 602
Number of HSP's that attempted gapping in prelim test: 13027
Number of HSP's gapped (non-prelim): 3424
length of query: 1332
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1218
effective length of database: 13,930,794
effective search space: 16967707092
effective search space used: 16967707092
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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