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Search of human proteins with 148833504
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
(1332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 2630 0.0
gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] 1236 0.0
gi|87196343 PDZ domain containing 2 [Homo sapiens] 229 1e-59
gi|148746189 multiple PDZ domain protein [Homo sapiens] 95 5e-19
gi|112382257 InaD-like [Homo sapiens] 83 2e-15
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 82 3e-15
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 82 3e-15
gi|45827729 scribble isoform b [Homo sapiens] 81 8e-15
gi|45827731 scribble isoform a [Homo sapiens] 81 8e-15
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 80 1e-14
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 80 1e-14
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 78 5e-14
gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 77 8e-14
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 77 1e-13
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 77 1e-13
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 76 2e-13
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 75 3e-13
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 75 5e-13
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 75 5e-13
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 74 9e-13
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 74 9e-13
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 74 9e-13
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 74 9e-13
gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 74 1e-12
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 72 3e-12
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 71 6e-12
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 70 1e-11
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 70 1e-11
gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 68 7e-11
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 66 3e-10
>gi|148833504 interleukin 16 isoform 2 [Homo sapiens]
Length = 1332
Score = 2630 bits (6817), Expect = 0.0
Identities = 1332/1332 (100%), Positives = 1332/1332 (100%)
Query: 1 MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS 60
MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS
Sbjct: 1 MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS 60
Query: 61 VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA 120
VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA
Sbjct: 61 VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA 120
Query: 121 QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL 180
QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL
Sbjct: 121 QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL 180
Query: 181 DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 240
DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG
Sbjct: 181 DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 240
Query: 241 PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR 300
PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR
Sbjct: 241 PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR 300
Query: 301 TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK 360
TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK
Sbjct: 301 TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK 360
Query: 361 EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE 420
EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE
Sbjct: 361 EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE 420
Query: 421 VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES 480
VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES
Sbjct: 421 VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES 480
Query: 481 SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS 540
SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS
Sbjct: 481 SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS 540
Query: 541 THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP 600
THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP
Sbjct: 541 THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP 600
Query: 601 PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC 660
PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC
Sbjct: 601 PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC 660
Query: 661 PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC 720
PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC
Sbjct: 661 PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC 720
Query: 721 IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK 780
IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK
Sbjct: 721 IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK 780
Query: 781 KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR 840
KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR
Sbjct: 781 KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR 840
Query: 841 QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP 900
QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP
Sbjct: 841 QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP 900
Query: 901 EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP 960
EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP
Sbjct: 901 EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP 960
Query: 961 SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE 1020
SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE
Sbjct: 961 SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE 1020
Query: 1021 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS 1080
GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS
Sbjct: 1021 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS 1080
Query: 1081 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT 1140
VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT
Sbjct: 1081 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT 1140
Query: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200
VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP
Sbjct: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200
Query: 1201 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP 1260
EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP
Sbjct: 1201 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP 1260
Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS 1320
LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS
Sbjct: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS 1320
Query: 1321 LQSKETTAAGDS 1332
LQSKETTAAGDS
Sbjct: 1321 LQSKETTAAGDS 1332
>gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens]
Length = 631
Score = 1236 bits (3197), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 702 MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 761
MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL
Sbjct: 1 MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 60
Query: 762 DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 821
DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA
Sbjct: 61 DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 120
Query: 822 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 881
SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG
Sbjct: 121 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 180
Query: 882 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 941
RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL
Sbjct: 181 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 240
Query: 942 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 1001
LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS
Sbjct: 241 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 300
Query: 1002 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 1061
LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL
Sbjct: 301 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 360
Query: 1062 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 1121
TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG
Sbjct: 361 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 420
Query: 1122 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 1181
AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI
Sbjct: 421 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 480
Query: 1182 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 1241
LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS
Sbjct: 481 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 540
Query: 1242 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301
AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW
Sbjct: 541 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600
Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
NIIKALPDGPVTIVIRRKSLQSKETTAAGDS
Sbjct: 601 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631
Score = 84.3 bits (207), Expect = 7e-16
Identities = 64/225 (28%), Positives = 113/225 (50%), Gaps = 24/225 (10%)
Query: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277
+L K + GLGFS+ GG D I ++ +F G A+ +G +Q+G+E+L +NG+S+ G
Sbjct: 414 ILHKEEGAGLGFSLAGGADLENKVITVH--RVFPNGLASQEGTIQKGNEVLSINGKSLKG 471
Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337
TH DAL +QA++ + V +LT P L+SST S A
Sbjct: 472 TTHHDALAILRQAREPRQAVIVTRKLT----------PEAMPDLNSST------DSAASA 515
Query: 338 SPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAH 394
S ++ +S + V+L+K AG+G + G S+ + ++ ++ + G+ +
Sbjct: 516 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLT---INRIFKGAASE 572
Query: 395 LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
++ GDEI+++ + + LT E + I+ GPV I++ R
Sbjct: 573 QSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617
Score = 64.3 bits (155), Expect = 7e-10
Identities = 38/107 (35%), Positives = 58/107 (54%), Gaps = 2/107 (1%)
Query: 196 SLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAA 255
S S A V +A+V + V ++ + GLGFS+ GGK S++G + + IF G A+
Sbjct: 514 SASAASDVSVESTAEATVCT--VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 571
Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302
+Q GDEIL+L G +M GLT +A K G +T+ +R +
Sbjct: 572 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618
Score = 35.8 bits (81), Expect = 0.28
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 358 LQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417
L KE G GLG L + I VH + P +A +G ++ G+E++ I+ + T
Sbjct: 415 LHKEEGAGLGFSLAGGADLEN-KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473
Query: 418 LNEVYTILSHCDPGPVPIIVSRHPDPQ 444
++ IL +IV+R P+
Sbjct: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 229 bits (585), Expect = 1e-59
Identities = 154/395 (38%), Positives = 216/395 (54%), Gaps = 23/395 (5%)
Query: 173 RKSLSQQLDCPAGKAAG--TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFS 230
+ SL Q LD + + TRSLST Q+ P ++ SVIS I L K + KGLGFS
Sbjct: 541 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS 600
Query: 231 IVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
I GG+D I G +GI+VKTIF G+AA DGRL+EGDEIL++NG + GLT Q+A+ FKQ
Sbjct: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660
Query: 291 KKGLLTLTVRTRLTAPP----SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ GL LTVRT+L +P S +H+S + ++S + S S S T
Sbjct: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG-SSSSLGRKTP 719
Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIV 406
P RI++EV+L KE VGLGIG C + GI++H+L+PGSVA ++ L GD+I+
Sbjct: 720 GPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779
Query: 407 EISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKE 466
E++ V L++V+ ILS C PGPV +++ RHP+P+VSEQ++ E +A++ KE
Sbjct: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQE--SKE 837
Query: 467 RHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPH---RRAQKVMIRSSSDSSYMSGSPGG 523
+ G S + +L E E + H M+ S D +
Sbjct: 838 ANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDH------- 890
Query: 524 SPGSG--SAEKPSSDVDISTH-SPSLPLAREPVVL 555
PGSG ++E+ S STH P P A V L
Sbjct: 891 -PGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL 924
Score = 208 bits (530), Expect = 2e-53
Identities = 177/526 (33%), Positives = 264/526 (50%), Gaps = 60/526 (11%)
Query: 833 SSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKP-LGKHEEGRF-SGLLGR- 889
S+S S++QRI SFE ++ D+ + P ++KP +G+ G SG LG
Sbjct: 2329 STSFFSVKQRIKSFENLANA---DRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHP 2385
Query: 890 -GAAPTLVPQQPEQVLSSGSPAASEARD--PGVSESPPP-----GRQPNQKTLPPGPDPL 941
AA L+ + LSS S SEA P +++SP RQ +T G D
Sbjct: 2386 GDAAARLLRRS----LSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSE 2441
Query: 942 LRL------LSTQAEESQGPVLKMPS--QRARSFPLTRSQSCETKLL-----DEKTSKLY 988
L+ + T PV + S + + P++RS+ E + L D+ S+ Y
Sbjct: 2442 LKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDY 2501
Query: 989 SISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGS------AET-- 1040
S S+ + K+ L I+ ++P P G S + GS AET
Sbjct: 2502 SAGP--SAVLFKTEL----EITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPS 2555
Query: 1041 SALDTGFSL-NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099
SA DTG + +L R ++ L + GD LQS S + S + LI+E K
Sbjct: 2556 SASDTGEAAQDLPFRRSWSVNLDQLLVSA-GDQQRLQSVLSSVG--SKSTILTLIQEAKA 2612
Query: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 1159
E + + +L+++EG+GLGFS+AGG D+E K ITVHRVF G ASQEGT+ +G
Sbjct: 2613 QSENE----EDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRG 2668
Query: 1160 NEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAA 1219
+ +LS+NG SL G H + L +L QA+ + A++V +K + P +A
Sbjct: 2669 DFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLL 2728
Query: 1220 SDVSV-------ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 1272
S ++ S A V + K SAGLG SL+GGK S+ GD PL I R++KG A+
Sbjct: 2729 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAA 2788
Query: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
EQ+ ++ GDEIL + G + GL F+AWNI+K++P+GPV ++IR+
Sbjct: 2789 EQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834
Score = 90.5 bits (223), Expect = 1e-17
Identities = 69/232 (29%), Positives = 112/232 (48%), Gaps = 27/232 (11%)
Query: 1111 IHVTILHKEEGAGLGFSLAGGADL--ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
I + L+KE+G GLGFS+AGG D I V +FPNG A+++G +++G+E+L +NG
Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643
Query: 1169 SLKGTTHHDALAILRQARE-----PRQAVIVTRKLTPEAMP-------DLNSSTDSAASA 1216
+KG T +A+ +Q R + +V+ LTP + P N +T ASA
Sbjct: 644 PIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA 703
Query: 1217 SAASDVSVESTAEAT-------VCTVTLEK---MSAGLGFSLEGGKGSLHGDKPLTINRI 1266
+ + S S T V VTL K + G+G + S G + I+ +
Sbjct: 704 GGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSL 760
Query: 1267 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
G+ ++ + GD+IL++ ++ + I+ P GPV +VI R
Sbjct: 761 APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812
Score = 79.7 bits (195), Expect = 2e-14
Identities = 69/228 (30%), Positives = 106/228 (46%), Gaps = 19/228 (8%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
IVL + + GLGFS+ GG D P I V +F+ GAA+ +G + GD +L +NG S+A
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTD--VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLC--RSLSSSTCITKDSSSF 334
GL H + L+ QA+ L V + P + PP + L S I +
Sbjct: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLE---- 2736
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSV 392
P S A + + VEV L+ AG+GL + G SV + + + G
Sbjct: 2737 ----PGIGRSVAVHD-ALCVEV-LKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGA 2787
Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRH 440
A G + GDEI+ I+ P+ L + + I+ GPV +++ +H
Sbjct: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKH 2835
Score = 62.4 bits (150), Expect = 3e-09
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 5/112 (4%)
Query: 223 QAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQD 282
++ GLG + GG+ S P I V + GGAA DGRL GDE+L +NG + GL+H++
Sbjct: 340 ESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399
Query: 283 ALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
A+ + A G++ L V ++ + L S +SL T +D SS+
Sbjct: 400 AVAILRSA-TGMVQLVVASKENSAEDLLRLTS----KSLPDLTSSVEDVSSW 446
Score = 60.8 bits (146), Expect = 8e-09
Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%)
Query: 1119 EEGAGLGFSLAGGADLENK--VITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
+E GLG ++GG + I V +V G A ++G + G+E+L ING L G +H
Sbjct: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398
Query: 1177 DALAILRQAREPRQAVIVTR--------KLTPEAMPDLNSSTDSAAS 1215
+A+AILR A Q V+ ++ +LT +++PDL SS + +S
Sbjct: 399 EAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445
Score = 52.4 bits (124), Expect = 3e-06
Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 6/165 (3%)
Query: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAA 1214
++++ NE++ NG L + R R+ ++ + + ST S +
Sbjct: 514 SVEEYNELMVRNGDP-----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568
Query: 1215 SASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQ 1274
+ S + + ++ + EK GLGFS+ GG+ + G + + IF ++ +
Sbjct: 569 TTQVESPWRLIRPSVISIIGLYKEK-GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627
Query: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
++ GDEIL + G ++GLT EA + K + G + +R K
Sbjct: 628 DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672
Score = 46.6 bits (109), Expect = 2e-04
Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
L K S GLG + GG+GS + + ++ +G A+ + + GDE+L + G + GL+
Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
Query: 1297 RFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
EA I+++ G V +V+ K +++
Sbjct: 397 HEEAVAILRS-ATGMVQLVVASKENSAED 424
Score = 30.8 bits (68), Expect = 9.1
Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 1/57 (1%)
Query: 382 IFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVS 438
I V + G AH DGRL GDE++ I+ + L+ E IL G V ++V+
Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSA-TGMVQLVVA 416
Score = 30.8 bits (68), Expect = 9.1
Identities = 72/331 (21%), Positives = 109/331 (32%), Gaps = 48/331 (14%)
Query: 493 EKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREP 552
E S P R K RS + GSP SPG +A P S S P
Sbjct: 1263 ENPSQPASPRVTKCKARSPVRLPH-EGSP--SPGEKAAAPPDYSKTRSASETSTPHNTRR 1319
Query: 553 VV-----------LSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSK-PKPP 600
V ++ A + LP + E R P K + P SS+ P
Sbjct: 1320 VAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLL 1379
Query: 601 PRKYFKSDSDPQKSLE-----ERENSSCS--SGHTPPTCGQEA--RELLPLLLPQEDTAG 651
S PQ SL + +C SGH P +E+ ++ + + +A
Sbjct: 1380 EGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAA 1439
Query: 652 RSPSASAGCPGP-----------GIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQA 700
RSPS+ G G G G + E PG + +SP + P + A
Sbjct: 1440 RSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSP-RRAWAAGAPAYPQWA 1498
Query: 701 RMDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPK 760
D+ D ++ + +S S H + G D T P
Sbjct: 1499 SQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFH-----------EDSTSLSGLGDSTEPS 1547
Query: 761 LDTANGTPKVYKSADSSTVKKGPPVAPKPAW 791
L + G + S+D ++ + P + + W
Sbjct: 1548 LSSMYGDAE-DSSSDPESLTEAPRASARDGW 1577
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 94.7 bits (234), Expect = 5e-19
Identities = 65/219 (29%), Positives = 113/219 (51%), Gaps = 7/219 (3%)
Query: 1103 ATLKQLDGIHVTILHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGN 1160
A ++ G+ + K LG S+AGG + L + I + + P G+A+Q ++ G+
Sbjct: 1823 ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGD 1882
Query: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 1220
+++I G S +G TH A+ +L+ A + +V S+ S + +
Sbjct: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLT 1942
Query: 1221 DVSV--ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-KGAASEQSET 1277
S+ + ++TLE+ GLGFS+ GG GS HGD P+ + +F KGAASE
Sbjct: 1943 SSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGR- 2001
Query: 1278 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316
++ GD+I+ + G +++G+T EA I+K G VT+++
Sbjct: 2002 LKRGDQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039
Score = 92.8 bits (229), Expect = 2e-18
Identities = 69/211 (32%), Positives = 113/211 (53%), Gaps = 26/211 (12%)
Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM-AG 277
L+K + GLGFS+VG + G +GI+V+ I G A DGRL+E D+IL +NG+++
Sbjct: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199
Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337
+THQ A+ ++AK + + R L P L +SP + RS S+++ I+ S+
Sbjct: 200 ITHQQAISILQKAKDTVQLVIARGSL---PQL---VSPIVSRSPSAASTISAHSN----- 248
Query: 338 SPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDG 397
P+ +++ M + L + G GLG G+ +G+ V T+ PG VA G
Sbjct: 249 ----PV-----HWQHMETIELVND-GSGLGFGIIGGK----ATGVIVKTILPGGVADQHG 294
Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
RL GD I++I D+ + ++ +V +L C
Sbjct: 295 RLCSGDHILKIGDTDLAGMSSEQVAQVLRQC 325
Score = 83.6 bits (205), Expect = 1e-15
Identities = 44/84 (52%), Positives = 62/84 (73%), Gaps = 2/84 (2%)
Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
+I L +G GLGFSIVGG S +G + IYVKT+FA GAA+ DGRL+ GD+I+ +NG+S+
Sbjct: 1958 SITLERGP-DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSL 2016
Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299
G+TH++A+ K+ KG +TL V
Sbjct: 2017 EGVTHEEAVAILKRT-KGTVTLMV 2039
Score = 81.6 bits (200), Expect = 4e-15
Identities = 74/258 (28%), Positives = 113/258 (43%), Gaps = 51/258 (19%)
Query: 173 RKSLSQQLDCP-AGKAAGTSRPTRSLSTAQLVQPSGGLQASVI----SNIVLMKGQAKGL 227
+K+ SQ L P +G S S S+ + S +I + I + KG+ GL
Sbjct: 1581 KKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRT-GL 1639
Query: 228 GFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKF 287
G SIVGG D++ G I I+ ++ GAA DGRL GD+ILE+NG + TH +A+
Sbjct: 1640 GLSIVGGSDTLLGAIIIH--EVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697
Query: 288 KQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAK 347
+Q + R RLT + +C +L+
Sbjct: 1698 RQTPQ-------RVRLTLYRDEAPYKEEEVCDTLT------------------------- 1725
Query: 348 PNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVE 407
+ LQK+ G GLG+ S+ + +G+FV + G +A DGRL GD+I+
Sbjct: 1726 --------IELQKKPGKGLGL---SIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILM 1774
Query: 408 ISDSPVHCLTLNEVYTIL 425
++ V T V +L
Sbjct: 1775 VNGEDVRNATQEAVAALL 1792
Score = 79.3 bits (194), Expect = 2e-14
Identities = 62/226 (27%), Positives = 98/226 (43%), Gaps = 15/226 (6%)
Query: 1114 TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
TI +G+GLGF + GG + + V + P G+A Q G + G+ +L I L G
Sbjct: 257 TIELVNDGSGLGFGIIGG---KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGM 313
Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS---DVSVESTAEA 1230
+ +LRQ + +I + P T S++ S D S + E+
Sbjct: 314 SSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEES 373
Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-----KGAASEQSETVQPGDEIL 1285
V L K GLG ++ G GDK L + IF K +A E +Q GD+I+
Sbjct: 374 ETFDVELTKNVQGLGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
Query: 1286 QLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
+ GT +QG T +A +++ + ++RR Q E + D
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSRED 475
Score = 78.2 bits (191), Expect = 5e-14
Identities = 65/230 (28%), Positives = 113/230 (49%), Gaps = 14/230 (6%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I L KG + GLG S+ G KD + +++ I GAA DGRLQ DE+LE+NG+ +
Sbjct: 1351 IELEKGHS-GLGLSLAGNKDR--SRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILY 1407
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTR-LTAPPSLC-SHLSPPLCRSLSSSTCITKDSSSF 334
G +HQ+A K A + + +R + ++C + PL S+S + +
Sbjct: 1408 GRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPL---PSNSENLQNKETEP 1464
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAH 394
+ + A + + +++ + + L K+ G GLGI + +SG+ + +L+ VA
Sbjct: 1465 TVTTSDAAVDLS--SFKNVQHLELPKDQG-GLGIAISEE---DTLSGVIIKSLTEHGVAA 1518
Query: 395 LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 444
DGRL+ GD+I+ + D V + + ++L I + +PD Q
Sbjct: 1519 TDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQ 1568
Score = 75.9 bits (185), Expect = 2e-13
Identities = 69/277 (24%), Positives = 125/277 (45%), Gaps = 33/277 (11%)
Query: 1030 EDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEE 1089
E+ AA A D +N +LR+ T D+ + Q+ Q V L +E
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATH--------DEAINVLRQTPQRVRLTLYRDE 1712
Query: 1090 LKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGL 1149
+E +V D T++ L K+ G GLG S+ G + + + V + G+
Sbjct: 1713 AP--YKEEEVCDTLTIE---------LQKKPGKGLGLSIVGKRN--DTGVFVSDIVKGGI 1759
Query: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209
A +G + +G+++L +NG+ ++ T A+L+ + L+ P SS
Sbjct: 1760 ADADGRLMQGDQILMVNGEDVRNATQEAVAALLK---------VSEGSLSSFTFPLSGSS 1810
Query: 1210 TDSAASASAASDVSVESTAEATVCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268
T + +S+ + TV ++K + LG S+ GG GS GD P+ I +
Sbjct: 1811 TSESLESSSKKNALASEIQGLR--TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1868
Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ Q++ ++ GD I+ + GT+ +G+T +A N++K
Sbjct: 1869 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905
Score = 72.4 bits (176), Expect = 3e-12
Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 35/201 (17%)
Query: 1101 DEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGN 1160
D AT + G TI + GLG S+ GG+D I +H V+ G A ++G + G+
Sbjct: 1616 DPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGD 1675
Query: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 1220
++L +NG L+ TH +A+ +LRQ TP+ + L D A
Sbjct: 1676 QILEVNGIDLRKATHDEAINVLRQ--------------TPQRV-RLTLYRDEA------- 1713
Query: 1221 DVSVESTAEATVC-TVTLE---KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
E VC T+T+E K GLG S+ G + D + ++ I KG ++
Sbjct: 1714 -----PYKEEEVCDTLTIELQKKPGKGLGLSIVGKR----NDTGVFVSDIVKGGIADADG 1764
Query: 1277 TVQPGDEILQLGGTAMQGLTR 1297
+ GD+IL + G ++ T+
Sbjct: 1765 RLMQGDQILMVNGEDVRNATQ 1785
Score = 72.4 bits (176), Expect = 3e-12
Identities = 69/239 (28%), Positives = 100/239 (41%), Gaps = 39/239 (16%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I L K KGLG SIVG ++ G++V I GG A ADGRL +GD+IL +NGE +
Sbjct: 1726 IELQKKPGKGLGLSIVGKRNDT----GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
T Q+A+ + +G L S + PL S S+S + S AL
Sbjct: 1782 NAT-QEAVAALLKVSEGSL---------------SSFTFPLSGS-STSESLESSSKKNAL 1824
Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
S + T + + + GVG +G VP IF+ + P VA
Sbjct: 1825 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLG--DVP-------IFIAMMHPTGVAAQT 1875
Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCD---------PGPVPIIVSRHPDPQVS 446
+LR GD IV I + +T + +L + G V ++ +P S
Sbjct: 1876 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASS 1934
Score = 64.3 bits (155), Expect = 7e-10
Identities = 69/275 (25%), Positives = 114/275 (41%), Gaps = 26/275 (9%)
Query: 171 SNRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASV-----ISNIVLMKGQAK 225
+ +++++ L G + + P ST++ ++ S A + + + KG
Sbjct: 1783 ATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTD 1842
Query: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
LG SI GG S G + I++ + G AA +L+ GD I+ + G S G+TH A+
Sbjct: 1843 SLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVN 1902
Query: 286 KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIST 345
K A + V + + H P SLS T +SS + P
Sbjct: 1903 LLKNASGSIEMQVVAGGDVSV--VTGHQQEPASSSLS----FTGLTSSSIFQDDLGP--- 1953
Query: 346 AKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVAHLDGRLRCG 402
P + S+ E G G+G V + G I+V T+ A DGRL+ G
Sbjct: 1954 --PQCK-----SITLERGPD-GLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRG 2005
Query: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437
D+I+ ++ + +T E IL G V ++V
Sbjct: 2006 DQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039
Score = 62.4 bits (150), Expect = 3e-09
Identities = 90/407 (22%), Positives = 160/407 (39%), Gaps = 47/407 (11%)
Query: 55 GIFHSSVQLADTSEA-GPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSRE 113
GIF S+ + E G + D +A + LQ N + R T R
Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463
Query: 114 KPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSA--APTDRQPYSLCS 171
+ E S + A + N++ + ++ DF + ++ PT+ + Y L S
Sbjct: 464 MKQEAELMSREDVTKDA--DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLS 521
Query: 172 NRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSI 231
+ + D +AA ++ R + G+ ++ V + GLG S+
Sbjct: 522 --AEIEEIEDAQKQEAALLTKWQRIM----------GINYEIVVAHVSKFSENSGLGISL 569
Query: 232 VGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAK 291
++ G +++++ G G+L GDE+LE+NG ++ G HQD + K+
Sbjct: 570 ----EATVGHH--FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
Query: 292 KGLLTLTVRTRLTAPPSLCSHL-SPPLC-----------------RSLSSSTCITKDSSS 333
+ V R T PP+ S L S LC S + + +
Sbjct: 624 --IEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAG 681
Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEA-GVGLGIGLCSVPYFQCISGIFVHTLSPGSV 392
+ E AP++ + + + L+K + G+G I P + I + +L PG +
Sbjct: 682 QSTEEVQAPLAMWEAGIQ---HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738
Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
A DGRL GD ++ ++D + +L E L G V I V++
Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785
Score = 62.4 bits (150), Expect = 3e-09
Identities = 72/299 (24%), Positives = 119/299 (39%), Gaps = 49/299 (16%)
Query: 1065 KEDDDGDHSSLQSGQSVISLLSSEE----LKKLIEEVKVLD--EATL----KQLDGIH-- 1112
KE+ + D L S ++ L + EE L IEE++ EA L +++ GI+
Sbjct: 491 KENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYE 550
Query: 1113 VTILHKE---EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 1169
+ + H E +GLG SL + V P G G + G+E+L +NG +
Sbjct: 551 IVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
Query: 1170 LKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL----------------------- 1206
L G H D + IL++ V R + P +L
Sbjct: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
Query: 1207 NSSTDSAASASAASDVSVESTA------EATVCTVTLEKMSAGLGFSLEGGKGSLH-GDK 1259
+S T+ A + S E EA + + LEK S GLGFS+ + +
Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAST 726
Query: 1260 PLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
+ I + G +E+ + PGD ++ + ++ + EA +K P G V I + +
Sbjct: 727 VIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785
Score = 58.9 bits (141), Expect = 3e-08
Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 68/314 (21%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS----IYGPI--GIYVKTIFAGGAAAADGRLQEGDEILEL 270
+ L + +K LG SIVGG+ G + GI++K + A +G L+ GD I+E+
Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
Query: 271 NGESMAGLTHQDALQKFKQAKKGLL----TLTVRTRLTAPPSLCSHLSP--------PLC 318
+G + +H+ A++ ++A ++ ++ R R + PSL +L P P
Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFA 1271
Query: 319 RSLSSSTCITKDSSSFALESPSAPISTAKP-----------------NYRIMVEVSLQKE 361
SL + K S E AP+ + P +I +V + E
Sbjct: 1272 DSLQINA--DKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE 1329
Query: 362 AGV--------------------------GLGIGLCSVPYFQCISGIFVHTLSPGSVAHL 395
G GLG+ L +S +F+ + P A
Sbjct: 1330 FGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMS-VFIVGIDPNGAAGK 1388
Query: 396 DGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVA 455
DGRL+ DE++EI+ ++ + +I+ C P V II R+ D + Q+
Sbjct: 1389 DGRLQIADELLEINGQILYGRSHQNASSIIK-CAPSKVKIIFIRNKD---AVNQMAVCPG 1444
Query: 456 QAVENTKFGKERHQ 469
AVE E Q
Sbjct: 1445 NAVEPLPSNSENLQ 1458
Score = 58.9 bits (141), Expect = 3e-08
Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 18/197 (9%)
Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170
+H+ L K +GLG SLAG D + + + PNG A ++G +Q +E+L ING+ L
Sbjct: 1348 LHMIELEKGH-SGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRK--------LTPEAMPDLNSSTDSAASAS----- 1217
G +H +A +I++ A + + + K A+ L S++++ +
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466
Query: 1218 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 1277
SD +V+ ++ V + L K GLG ++ + +L G + I + + +
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSG---VIIKSLTEHGVAATDGR 1522
Query: 1278 VQPGDEILQLGGTAMQG 1294
++ GD+IL + + G
Sbjct: 1523 LKVGDQILAVDDEIVVG 1539
Score = 58.5 bits (140), Expect = 4e-08
Identities = 64/266 (24%), Positives = 111/266 (41%), Gaps = 47/266 (17%)
Query: 225 KGLGFSIVGG-KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
+GLG +I G D P GI+VK+I A DGR+Q GD+I+ ++G ++ G T+Q A
Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444
Query: 284 LQKFKQAKKGLLTLTVRTRLTAPPSLCSH--------LSPPLCRSLSSS-------TCIT 328
++ + + +L +R + L S LSP + + T
Sbjct: 445 VEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSST 504
Query: 329 KDSSSFALESPSAPISTAK-----------------------PNYRIMVEVSLQKEAGVG 365
++++ E P+ +A+ NY I+V + G
Sbjct: 505 RNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSG 564
Query: 366 LGIGLCSVPYFQCISGIFVHTLSP-GSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTI 424
LGI L + + F+ ++ P G V H G+L GDE++E++ + +V I
Sbjct: 565 LGISLEAT-----VGHHFIRSVLPEGPVGH-SGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 425 LSHCDPGPVPIIVSRHPDPQVSEQQL 450
L P V ++ R P ++ +L
Sbjct: 619 LKEL-PIEVTMVCCRRTVPPTTQSEL 643
Score = 55.8 bits (133), Expect = 3e-07
Identities = 74/303 (24%), Positives = 123/303 (40%), Gaps = 41/303 (13%)
Query: 172 NRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASV-------ISNIVLMKGQA 224
N+ +++Q CP + +L + A+V + ++ L K Q
Sbjct: 1432 NKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG 1491
Query: 225 KGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDAL 284
GLG +I +D++ G I +K++ G AA DGRL+ GD+IL ++ E + G + +
Sbjct: 1492 -GLGIAI-SEEDTLSGVI---IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFI 1546
Query: 285 QKFKQAKKGLLTLTVRTR---LTAPPSLCSHLSPPLCRSLSS---------------STC 326
K AK + LT+ A PS S S S +T
Sbjct: 1547 SLLKTAKM-TVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605
Query: 327 ITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG-IFVH 385
+ + FA + + PI P +E+S + G+GL V + G I +H
Sbjct: 1606 RSSTPAIFASDPATCPII---PGCETTIEISKGRT-----GLGLSIVGGSDTLLGAIIIH 1657
Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445
+ A DGRL GD+I+E++ + T +E +L P V + + R P
Sbjct: 1658 EVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ-TPQRVRLTLYRDEAPYK 1716
Query: 446 SEQ 448
E+
Sbjct: 1717 EEE 1719
Score = 55.5 bits (132), Expect = 3e-07
Identities = 55/238 (23%), Positives = 112/238 (47%), Gaps = 34/238 (14%)
Query: 1116 LHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
L K++G GLG +++ L +I + +G+A+ +G ++ G+++L+++ + + G
Sbjct: 1486 LPKDQG-GLGIAISEEDTLSGVIIK--SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDL---------NSST------------DSAA 1214
+++L+ A+ + I +A+P NSS +S
Sbjct: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602
Query: 1215 SASAASDVSVESTAEATV-----CTVTLE--KMSAGLGFSLEGGKGSLHGDKPLTINRIF 1267
+ S +S ++ ++ AT C T+E K GLG S+ GG +L G + I+ ++
Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG--AIIIHEVY 1660
Query: 1268 KGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
+ A+ + + GD+IL++ G ++ T EA N+++ P V + + R KE
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ-RVRLTLYRDEAPYKE 1717
Score = 49.7 bits (117), Expect = 2e-05
Identities = 36/111 (32%), Positives = 59/111 (53%), Gaps = 3/111 (2%)
Query: 198 STAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIY-GPIGIYVKTIFAGGAAA 256
ST ++ P +A I +I L KG +KGLGFSI+ +D I I ++++ GG A
Sbjct: 683 STEEVQAPLAMWEAG-IQHIELEKG-SKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAE 740
Query: 257 ADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 307
DGRL GD ++ +N ++ + ++A++ K A G + + V L P
Sbjct: 741 KDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
Score = 48.5 bits (114), Expect = 4e-05
Identities = 61/245 (24%), Positives = 98/245 (40%), Gaps = 28/245 (11%)
Query: 184 AGKAAGTSRPTRSLS-TAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI 242
AGK + SL+ A+ V + S I + KG + LG ++ KD +
Sbjct: 975 AGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSS-LGMTVSANKDGL---- 1029
Query: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302
G+ V++I GGA + DGR+ GD IL +N ES +T+ A + + L+ ++
Sbjct: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR--RHSLIGPDIKIT 1087
Query: 303 LTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAP------------ISTAKPNY 350
P L + + SS + P P +TA N+
Sbjct: 1088 Y-VPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNW 1146
Query: 351 RIMVEVSLQKEAGVGLGIGLCS-------VPYFQCISGIFVHTLSPGSVAHLDGRLRCGD 403
V L +E LGI + + + + GIF+ + S A +G L+ GD
Sbjct: 1147 NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGD 1206
Query: 404 EIVEI 408
IVE+
Sbjct: 1207 RIVEV 1211
Score = 44.7 bits (104), Expect = 6e-04
Identities = 60/279 (21%), Positives = 102/279 (36%), Gaps = 71/279 (25%)
Query: 1095 EEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEG 1154
EE + D K + G+ +TI G LE I V + + +G
Sbjct: 371 EESETFDVELTKNVQGLGITIA----------GYIGDKKLEPSGIFVKSITKSSAVEHDG 420
Query: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQARE-----------PRQAVIVTRK------ 1197
IQ G+++++++G +L+G T+ A+ +LR + ++A +++R+
Sbjct: 421 RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA 480
Query: 1198 -LTP----------EAMPDLNSSTDS--------------AASASAASDVSVESTA---- 1228
L+P E D SST + +A D + A
Sbjct: 481 DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540
Query: 1229 ---------EATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ 1279
E V V+ ++GLG SLE G I + S +
Sbjct: 541 WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHF------IRSVLPEGPVGHSGKLF 594
Query: 1280 PGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
GDE+L++ G + G + NI+K LP + RR
Sbjct: 595 SGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRR 633
Score = 43.1 bits (100), Expect = 0.002
Identities = 36/147 (24%), Positives = 60/147 (40%), Gaps = 16/147 (10%)
Query: 1200 PEAMPDLNSSTDSAASASAASDVSVES--------------TAEATVCTVTLEKMSAGLG 1245
P A ++ S ++++ + DV E T + + LEK +GLG
Sbjct: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361
Query: 1246 FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
SL G K + I I A+ + +Q DE+L++ G + G + A +IIK
Sbjct: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
Query: 1306 ALPDGPVTIVIRRKSLQSKETTAAGDS 1332
P I IR K ++ G++
Sbjct: 1420 CAPSKVKIIFIRNKDAVNQMAVCPGNA 1446
Score = 40.4 bits (93), Expect = 0.011
Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 2/86 (2%)
Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGL 1295
L+ S GLGFS+ G + G+ + + I +G+ + + ++ D+IL + G A+ Q +
Sbjct: 141 LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200
Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSL 1321
T +A +I++ D V +VI R SL
Sbjct: 201 THQQAISILQKAKD-TVQLVIARGSL 225
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 83.2 bits (204), Expect = 2e-15
Identities = 68/238 (28%), Positives = 108/238 (45%), Gaps = 33/238 (13%)
Query: 210 QASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILE 269
Q I I + + GLGFS+V + G + I+VK + G A D RL+E D+IL
Sbjct: 128 QGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILA 187
Query: 270 LNGESM-AGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCIT 328
+N + ++HQ A+ +Q L + R + T
Sbjct: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH-----------------------T 224
Query: 329 KDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLS 388
K S+S +L + P + + + EV L + G GLG G+ SG+ V T+
Sbjct: 225 KSSTSSSLNDTTLPETVC---WGHVEEVELIND-GSGLGFGIVGGK----TSGVVVRTIV 276
Query: 389 PGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVS 446
PG +A DGRL+ GD I++I + V +T +V +L +C V ++V+R P +S
Sbjct: 277 PGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG-NSVRMLVARDPAGDIS 333
Score = 80.9 bits (198), Expect = 8e-15
Identities = 70/223 (31%), Positives = 106/223 (47%), Gaps = 47/223 (21%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I + KG++ GLG SIVGGKD+ I I+ ++ GAAA DGRL GD+ILE+NG +
Sbjct: 1438 IEISKGRS-GLGLSIVGGKDTPLNAIVIH--EVYEEGAAARDGRLWAGDQILEVNGVDLR 1494
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
+H++A+ +Q + + RL + +D + +
Sbjct: 1495 NSSHEEAITALRQTPQ-------KVRLV----------------------VYRDEAHYRD 1525
Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
E N I V LQK+AG GLG+ S+ + SG+F+ + G A LD
Sbjct: 1526 EE----------NLEIF-PVDLQKKAGRGLGL---SIVGKRNGSGVFISDIVKGGAADLD 1571
Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
GRL GD+I+ ++ + + V TIL C G V + + R
Sbjct: 1572 GRLIQGDQILSVNGEDMRNASQETVATILK-CAQGLVQLEIGR 1613
Score = 77.8 bits (190), Expect = 6e-14
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 24/203 (11%)
Query: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285
GLGF IVGGK S G+ V+TI GG A DGRLQ GD IL++ G ++ G+T + Q
Sbjct: 257 GLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311
Query: 286 KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIST 345
+ +VR + P+ ++PP +L + + A + P + S
Sbjct: 312 VLRNCGN-----SVRMLVARDPAGDISVTPPAPAALPVAL------PTVASKGPGSDSSL 360
Query: 346 AKPNYRIMVEVSLQKEAGVGLGI---GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCG 402
+ V L ++ G LGI G + SGI+V ++ PGS A+ +G ++
Sbjct: 361 FE-----TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415
Query: 403 DEIVEISDSPVHCLTLNEVYTIL 425
D+IV + + ++V +L
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVL 438
Score = 77.0 bits (188), Expect = 1e-13
Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 46/345 (13%)
Query: 978 KLLDEKTSKLYSISSQVSSAVMKS------LLCLPSSISCAQTPCIPKEGASPTSSSNED 1031
+LL+ LY S Q +SA++K+ L+ + + + Q P S + SS ED
Sbjct: 1286 ELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIED 1345
Query: 1032 SAAN---GSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSE 1088
+ S E +++ G L E + +++ K+ S S + ++ SS
Sbjct: 1346 QSGTEPISSEEDGSVEVGIK-QLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSY 1404
Query: 1089 ELKKL-------IEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITV 1141
+ +D AT + G + I + +GLG S+ GG D I +
Sbjct: 1405 HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVI 1464
Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPE 1201
H V+ G A+++G + G+++L +NG L+ ++H +A+ LRQ + + V+
Sbjct: 1465 HEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY------- 1517
Query: 1202 AMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKP 1260
+ + V L+K + GLG S+ G +
Sbjct: 1518 -----------------RDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNG----SG 1556
Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ I+ I KG A++ + GD+IL + G M+ ++ I+K
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
Score = 73.9 bits (180), Expect = 9e-13
Identities = 55/215 (25%), Positives = 97/215 (45%), Gaps = 22/215 (10%)
Query: 1120 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179
+G+GLGF + GG + + V + P GLA ++G +Q G+ +L I G +++G T
Sbjct: 254 DGSGLGFGIVGG---KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310
Query: 1180 AILRQ---------AREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 1230
+LR AR+P + V TP A L + + AS SD S+ T
Sbjct: 311 QVLRNCGNSVRMLVARDPAGDISV----TPPAPAALPVALPTVASKGPGSDSSLFETYNV 366
Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKP--LTINRIFKGAASEQSETVQPGDEILQLG 1288
+ + K LG + G G+ H + + + I G+A+ + +Q D+I+ +
Sbjct: 367 EL----VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422
Query: 1289 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 1323
G +QG + +++ ++RRK+ S
Sbjct: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457
Score = 67.8 bits (164), Expect = 7e-11
Identities = 62/269 (23%), Positives = 121/269 (44%), Gaps = 27/269 (10%)
Query: 1041 SALDTGFSLNLSELREYTEG-LTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099
S F + L +T+G +T ++S++ L +E+ +I+++
Sbjct: 69 SDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQM-- 126
Query: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAG--GADLENKVITVHRVFPNGLASQEGTIQ 1157
A +Q++ I + + GLGFS+ +L I V V P +A ++ ++
Sbjct: 127 ---AQGRQIEYIDI---ERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK 180
Query: 1158 KGNEVLSINGKSL-KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
+ +++L+IN L + +H A+A+L+Q + ++ + T S+ S+
Sbjct: 181 ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPV----------HTKSSTSS 230
Query: 1217 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
S E+ V V L +GLGF + GGK S + + I G +++
Sbjct: 231 SLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDG 285
Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+Q GD IL++GGT +QG+T + +++
Sbjct: 286 RLQTGDHILKIGGTNVQGMTSEQVAQVLR 314
Score = 65.5 bits (158), Expect = 3e-10
Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 29/232 (12%)
Query: 1101 DEATLKQLDGIHV--TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQK 1158
DEA + + + + L K+ G GLG S+ G + + + + G A +G + +
Sbjct: 1519 DEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQ 1576
Query: 1159 GNEVLSINGKSLKGTTHHDALAILRQAREPRQAVI--------VTRKLTPEAMPDLNSST 1210
G+++LS+NG+ ++ + IL+ A+ Q I + + T + S
Sbjct: 1577 GDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSA 1636
Query: 1211 DSAASASAA---------------SDVSVESTA-EATVCTVTLEK-MSAGLGFSLEGGKG 1253
S+ S A SD S +++ + TV + + +S LG S+ GG+G
Sbjct: 1637 HSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696
Query: 1254 SLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
S GD P+ I I + +++ ++ GD I+ + G + GL+ + N++K
Sbjct: 1697 SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748
Score = 63.9 bits (154), Expect = 1e-09
Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 29/226 (12%)
Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGL 278
L K +GLG SIVG ++ G+++ I GGAA DGRL +GD+IL +NGE M
Sbjct: 1536 LQKKAGRGLGLSIVGKRNGS----GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591
Query: 279 THQDALQKFKQAKKGLLTLTV---------RTRLTAPPSLCSHLSPPLCRSLSSSTCITK 329
+ Q+ + + +GL+ L + R T+ S S S S + IT
Sbjct: 1592 S-QETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITG 1650
Query: 330 DSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC--------SVPYFQCISG 381
+ + S P V + +E LGI + +P
Sbjct: 1651 LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIP------- 1703
Query: 382 IFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
+F+ + VA +L+ GD IV I+ P+ L+ +V +L +
Sbjct: 1704 VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Score = 62.0 bits (149), Expect = 4e-09
Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 73/301 (24%)
Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
+I+ ++ GLG S+ G KD + I+V I G AAADGR++ GDE+LE+N + +
Sbjct: 1238 HIIELEKDKNGLGLSLAGNKDR--SRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 276 AGLTHQDALQKFKQAKKGLLTLTVR-----TRLTAPPSLCSHLSPPLCRSLSSSTCITK- 329
G +HQ+A K A + + +R ++ P SP S + I+
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355
Query: 330 -------------DSSSFAL-------------------ESPSAPIST------------ 345
+S SF L E P AP S+
Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415
Query: 346 --------------AKPNYRIMVEVSLQKEAGVGLGI-GLCSVPYFQCISGIFVHTLSPG 390
P +++E+S + +G+GL I G P ++ I +H +
Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEIS-KGRSGLGLSIVGGKDTP----LNAIVIHEVYEE 1470
Query: 391 SVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQL 450
A DGRL GD+I+E++ + + E T L P V ++V R E+ L
Sbjct: 1471 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQ-TPQKVRLVVYRDEAHYRDEENL 1529
Query: 451 K 451
+
Sbjct: 1530 E 1530
Score = 56.6 bits (135), Expect = 2e-07
Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 10/129 (7%)
Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170
+H+ L K++ GLG SLAG D I V + P G A+ +G ++ G+E+L IN + L
Sbjct: 1237 LHIIELEKDKN-GLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRK-------LTPEAMPDLNSSTDSAASASAASDVS 1223
G +H +A AI++ A + V + + +TP +P +SS S S +S
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP--SSSPSSIEDQSGTEPIS 1353
Query: 1224 VESTAEATV 1232
E V
Sbjct: 1354 SEEDGSVEV 1362
Score = 56.2 bits (134), Expect = 2e-07
Identities = 46/196 (23%), Positives = 85/196 (43%), Gaps = 11/196 (5%)
Query: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200
+ + G G +Q +E+L +NG L G + +A++ L++ P V R
Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDD 642
Query: 1201 EAMPDLNSSTDSAASASAAS---DVSVESTAEATVCT-------VTLEKMSAGLGFSLEG 1250
EA D T+++ + DV+ E + + V L K GLGFS+
Sbjct: 643 EASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD 702
Query: 1251 GKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD 1309
+ L + + + R + +E+S + PGD ++ + + + EA I+KA+P
Sbjct: 703 YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPP 762
Query: 1310 GPVTIVIRRKSLQSKE 1325
G V + I + ++ E
Sbjct: 763 GLVHLGICKPLVEDNE 778
Score = 54.7 bits (130), Expect = 6e-07
Identities = 30/89 (33%), Positives = 50/89 (56%), Gaps = 1/89 (1%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LG SI GG+ S G I +++ I A G AA +L+ GD I+ +NG+ + GL+H D +
Sbjct: 1687 LGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNL 1746
Query: 287 FKQA-KKGLLTLTVRTRLTAPPSLCSHLS 314
K A + +L + T ++A + ++S
Sbjct: 1747 LKNAYGRIILQVVADTNISAIAAQLENMS 1775
Score = 53.5 bits (127), Expect = 1e-06
Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 47/254 (18%)
Query: 227 LGFSIVGGKDSIYGPI------GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTH 280
LG SIVGG+ I GI++K + A L+ GD+ILE++G + +H
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138
Query: 281 QDALQKFKQAKKGLL----TLTVRTRL----------------------------TAPPS 308
+A++ K A ++ +L+ R+ TAPP
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198
Query: 309 LCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI 368
+ PP ++L+ + ++ +F + + I + L+K+ GLG+
Sbjct: 1199 M---KLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHI---IELEKDKN-GLGL 1251
Query: 369 GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
L +S IFV ++P A DGR+R GDE++EI++ ++ + I+
Sbjct: 1252 SLAGNKDRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTA 1310
Query: 429 DPGPVPIIVSRHPD 442
P V ++ R+ D
Sbjct: 1311 -PSKVKLVFIRNED 1323
Score = 50.8 bits (120), Expect = 8e-06
Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 65/316 (20%)
Query: 183 PAGKAAGTSRPTRSLSTA--QLVQPSGGLQASVIS--NIVLMKGQAKGLGFSIVG--GKD 236
PAG + T +L A + G +S+ N+ L++ + LG IVG G
Sbjct: 328 PAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTS 387
Query: 237 SIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLT 296
GIYVK+I G AA +G +Q D+I+ ++G ++ G + D ++ + A + +
Sbjct: 388 HTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447
Query: 297 LTVRTRLTA------PPS----LCSHLSPP---LCRSLSSSTCI-------------TKD 330
VR + ++ PPS + L PP L ++ + T + K+
Sbjct: 448 TLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKN 507
Query: 331 SSSFALES----PSAPISTAK--------PNYRIMV---------EVSLQKEA------G 363
+ ALE P +P + K P+Y +MV + LQK +
Sbjct: 508 DNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHT 567
Query: 364 VGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYT 423
+ LG+ + S IS I +S G V L G L+ DE++E++ ++ + E +
Sbjct: 568 LRLGVEVDSFDGHHYISSI----VSGGPVDTL-GLLQPEDELLEVNGMQLYGKSRREAVS 622
Query: 424 ILSHCDPGPVPIIVSR 439
L P P ++ R
Sbjct: 623 FLKEVPP-PFTLVCCR 637
Score = 50.1 bits (118), Expect = 1e-05
Identities = 50/254 (19%), Positives = 96/254 (37%), Gaps = 52/254 (20%)
Query: 1116 LHKEEGAGLGFSLAGGADL--------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
+ +E LG S+ GG + E K I + +V + A + ++ G+++L ++G
Sbjct: 1071 IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSG 1130
Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS---------- 1217
L+ +H +A+ ++ A P ++ + TP +P++++ +
Sbjct: 1131 VDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEK 1190
Query: 1218 ----------------AASDVSVESTAE----------------ATVCTVTLEKMSAGLG 1245
A +D S E+ E + + LEK GLG
Sbjct: 1191 RQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLG 1250
Query: 1246 FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
SL G K + + I + ++ GDE+L++ + G + A IIK
Sbjct: 1251 LSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308
Query: 1306 ALPDGPVTIVIRRK 1319
P + IR +
Sbjct: 1309 TAPSKVKLVFIRNE 1322
Score = 46.6 bits (109), Expect = 2e-04
Identities = 47/190 (24%), Positives = 76/190 (40%), Gaps = 7/190 (3%)
Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLT 304
Y+ +I +GG G LQ DE+LE+NG + G + ++A+ K+ + R
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 305 APPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEA-G 363
S+ P + T + + E ++ P +I V L K+ G
Sbjct: 642 DEASVD---EPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKI---VELVKDCKG 695
Query: 364 VGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYT 423
+G I P S I + +L VA G L GD +V +++ + +L E
Sbjct: 696 LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVE 755
Query: 424 ILSHCDPGPV 433
IL PG V
Sbjct: 756 ILKAVPPGLV 765
Score = 43.9 bits (102), Expect = 0.001
Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 1116 LHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLK 1171
L +++G LG + G E I V + P A G IQ +++++++G +++
Sbjct: 368 LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427
Query: 1172 GTTHHDALAILRQAREPRQAVIVTRKLTPEAMP 1204
G +HD + +LR A + +V RK + P
Sbjct: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSP 460
Score = 41.6 bits (96), Expect = 0.005
Identities = 21/72 (29%), Positives = 44/72 (61%), Gaps = 2/72 (2%)
Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
+++E LG S+AGG + L + + + + +G+A++ ++ G+ ++SING+ L G
Sbjct: 1679 INRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738
Query: 1174 THHDALAILRQA 1185
+H D + +L+ A
Sbjct: 1739 SHADVVNLLKNA 1750
Score = 37.0 bits (84), Expect = 0.13
Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 8/86 (9%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPL---TINRIFKGAASEQSETVQPGDEILQLGGTA 1291
+ + K +GLG S+ GGK D PL I+ +++ A+ + + GD+IL++ G
Sbjct: 1438 IEISKGRSGLGLSIVGGK-----DTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492
Query: 1292 MQGLTRFEAWNIIKALPDGPVTIVIR 1317
++ + EA ++ P +V R
Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYR 1518
Score = 36.6 bits (83), Expect = 0.17
Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 1/84 (1%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYV-KTIFAGGAAAADGRLQEGDEILELNGESM 275
IV + KGLGFSI+ +D + + V +++ A G A G L GD ++ +N +
Sbjct: 686 IVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745
Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299
+ +A++ K GL+ L +
Sbjct: 746 DNTSLAEAVEILKAVPPGLVHLGI 769
Score = 34.7 bits (78), Expect = 0.63
Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 1218 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 1277
A D + AE + L + LG ++ G + I+ I G +
Sbjct: 544 ATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHY------ISSIVSGGPVDTLGL 597
Query: 1278 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
+QP DE+L++ G + G +R EA + +K +P P T+V R+
Sbjct: 598 LQPEDELLEVNGMQLYGKSRREAVSFLKEVPP-PFTLVCCRR 638
Score = 33.1 bits (74), Expect = 1.8
Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 26/137 (18%)
Query: 1050 NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD 1109
++ E R L E + D + D ++ + ++L S E K++E VK
Sbjct: 645 SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEV--KIVELVK----------- 691
Query: 1110 GIHVTILHKEEGAGLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166
+ GLGFS+ D VI + + +G+A + G + G+ ++S+N
Sbjct: 692 ----------DCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741
Query: 1167 GKSLKGTTHHDALAILR 1183
L T+ +A+ IL+
Sbjct: 742 EYCLDNTSLAEAVEILK 758
Score = 31.6 bits (70), Expect = 5.3
Identities = 17/90 (18%), Positives = 49/90 (54%), Gaps = 2/90 (2%)
Query: 1241 SAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGLTRFE 1299
+ GLGFS+ + G + + + G+ +++ + ++ D+IL + T + Q ++ +
Sbjct: 142 TGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201
Query: 1300 AWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329
A +++ G + +++ R+ + +K +T++
Sbjct: 202 AIALLQQ-TTGSLRLIVAREPVHTKSSTSS 230
>gi|119120907 par-3 partitioning defective 3 homolog B isoform a
[Homo sapiens]
Length = 1104
Score = 82.0 bits (201), Expect = 3e-15
Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%)
Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
+K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
++ + + K+G V R H P R L D + +LE+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491
Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397
+ ++ E+ L GLG+ L + + GIF+ ++ G A DG
Sbjct: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
Query: 398 RLRCGDEIVEIS 409
RLR D+++ ++
Sbjct: 543 RLRMNDQLIAVN 554
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)
Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V +
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257
+P +L D A +S+E++ + T + SAGLG SL+G K G
Sbjct: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522
Query: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310
D + I I G A+ + ++ D+++ + G ++ G + EA ++ G
Sbjct: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582
Query: 1311 PVTIVIRRKSLQSKETTA 1328
+ +VI R+ + E A
Sbjct: 583 MIQLVILRRPERPMEDPA 600
Score = 63.5 bits (153), Expect = 1e-09
Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
I L + GLG S+ G K G +GI++K+I GGAA DGRL+ D+++ +NGES+
Sbjct: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
Query: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326
G ++ +A++ +++ +G++ L + R P P+ C S P + ++
Sbjct: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618
Query: 327 ITKDSSSFALESPSAPISTAKP 348
++ + + L P+ T P
Sbjct: 619 TSRRNDNSILH----PLGTCSP 636
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
DA A L+Q + PR + + +P P + S A +
Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
+ E ++++ G ++VI R+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469
Score = 45.4 bits (106), Expect = 4e-04
Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%)
Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
+ T L P S ++ V + G+ LG +V S+ G I G++++ I +
Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242
Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
+G E + I+++N + T A F+QA K L L + R S+
Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302
Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
L+ PP+ +L+ + D+S+ + SP P KP
Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362
Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+ + +++ L+K G+G V I G IFV + P
Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
A DGRL+ GD I+E++ V T E+ +L G +V + ++LK
Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479
>gi|119120903 par-3 partitioning defective 3 homolog B isoform c
[Homo sapiens]
Length = 1136
Score = 82.0 bits (201), Expect = 3e-15
Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%)
Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
+K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
++ + + K+G V R H P R L D + +LE+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491
Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397
+ ++ E+ L GLG+ L + + GIF+ ++ G A DG
Sbjct: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542
Query: 398 RLRCGDEIVEIS 409
RLR D+++ ++
Sbjct: 543 RLRMNDQLIAVN 554
Score = 71.2 bits (173), Expect = 6e-12
Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%)
Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V +
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257
+P +L D A +S+E++ + T + SAGLG SL+G K G
Sbjct: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522
Query: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310
D + I I G A+ + ++ D+++ + G ++ G + EA ++ G
Sbjct: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582
Query: 1311 PVTIVIRRKSLQSKETTA 1328
+ +VI R+ + E A
Sbjct: 583 MIQLVILRRPERPMEDPA 600
Score = 63.5 bits (153), Expect = 1e-09
Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
I L + GLG S+ G K G +GI++K+I GGAA DGRL+ D+++ +NGES+
Sbjct: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558
Query: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326
G ++ +A++ +++ +G++ L + R P P+ C S P + ++
Sbjct: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618
Query: 327 ITKDSSSFALESPSAPISTAKP 348
++ + + L P+ T P
Sbjct: 619 TSRRNDNSILH----PLGTCSP 636
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
DA A L+Q + PR + + +P P + S A +
Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
+ E ++++ G ++VI R+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469
Score = 45.4 bits (106), Expect = 4e-04
Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%)
Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
+ T L P S ++ V + G+ LG +V S+ G I G++++ I +
Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242
Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
+G E + I+++N + T A F+QA K L L + R S+
Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302
Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
L+ PP+ +L+ + D+S+ + SP P KP
Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362
Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+ + +++ L+K G+G V I G IFV + P
Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
A DGRL+ GD I+E++ V T E+ +L G +V + ++LK
Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 80.9 bits (198), Expect = 8e-15
Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%)
Query: 801 NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 860
+R S + L P A+ E G RA+ S ++ S E S P
Sbjct: 443 SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497
Query: 861 RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 914
QP SG PL EE R S G R +A T+ +PE + + EA
Sbjct: 498 ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551
Query: 915 RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 973
G E Q + T+ D LL + EE Q +P R R L R
Sbjct: 552 TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606
Query: 974 SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 1026
+ K K + IS + +LL + P P +P +
Sbjct: 607 TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657
Query: 1027 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 1086
E+ GS + + E R E + +ED +G ++ S SV +
Sbjct: 658 QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709
Query: 1087 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 1141
+ LIE ++ +E + +TIL + GLG S+AGG +++ I +
Sbjct: 710 DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760
Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 1188
RV G A++ G ++ G+++L +NG +L+G HH+A+ LR A EP
Sbjct: 761 SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819
Query: 1189 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 1247
AV +T L PE D S + + ES V L + GLGFS
Sbjct: 820 ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875
Query: 1248 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 1289
+ GGKGS GD + ++RI +G A+ ++ T+Q GD +L + G
Sbjct: 876 IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920
Score = 75.1 bits (183), Expect = 4e-13
Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 17/240 (7%)
Query: 216 NIVLMKGQAKGLGFSIVGGKDSI---YGPIGIYVKTIFAGGAAAADGRLQEGDEILELNG 272
++ + +GLGFSI GGK S G GI+V I GGAA G LQ GD +L +NG
Sbjct: 861 HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920
Query: 273 ESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAPPSLCSHLSPPLCR-SLSSSTCITKD 330
+ H A+ A + L R PPS H SPP + +S T T
Sbjct: 921 VDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980
Query: 331 SSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGL------CSVPYFQCISGIFV 384
+PS + + Y + E+ L + AG LG+ + S P+ G+F+
Sbjct: 981 VPGLPSLAPSLLAAALEGPYPV-EEIRLPR-AGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038
Query: 385 HTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE-VYTILSHCDPGPVPIIVSRHPDP 443
+ P +A G LR GD I+ ++ V T E V +L C + ++V R P P
Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAP 1095
Score = 72.0 bits (175), Expect = 4e-12
Identities = 115/503 (22%), Positives = 180/503 (35%), Gaps = 97/503 (19%)
Query: 227 LGFSIVGGKDSIYGPIGI-----YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
LG SIVGG D P G+ ++ + G AA G L+ GD IL +NG+ + THQ
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQ 1072
Query: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341
+A+ + L +L VR R APP L CI K
Sbjct: 1073 EAVSALLRPCLEL-SLLVR-RDPAPPGL-------------RELCIQK------------ 1105
Query: 342 PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRC 401
P R+ + + G G P GIF+ +SP A DGRLR
Sbjct: 1106 -----APGERLGISIR-------GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153
Query: 402 GDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENT 461
G ++E++ + LT E +L ++ + S E + N
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF---EASTDAALEVSPGVIANP 1210
Query: 462 KFGKERHQWSLEGVKRLESS------------------WHGRPTLEKEREKNSAPPHRRA 503
H+ SLE + ++ W T R RA
Sbjct: 1211 FAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRA 1270
Query: 504 QKVMIRSSSDSSYMSGSPGG----SPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIAS 559
+ + S SG+ GG SP S S ++P S ++ A ++ +
Sbjct: 1271 LAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYR-AFAAVPT 1329
Query: 560 SRLPQES---PPLPESRDSHPPLRLK---KSFEILVRKPMSSKPKPPPRKYFKSDSDPQK 613
S P+++ PP P S L + K FE+ VR P + + PP++ +D +
Sbjct: 1330 SHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQA---EGPPKRVSLVGADDLR 1386
Query: 614 SLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSST 673
++E E Q+ ++L + A A G +G + +
Sbjct: 1387 KMQEEEARKLQ---------QKRAQML------REAAEAGAEARLALDGETLGEEEQE-- 1429
Query: 674 EGEPGWRRASPVTQTSPIKHPLL 696
+ +P W SP ++ SP P L
Sbjct: 1430 DEQPPWASPSPTSRQSPASPPPL 1452
Score = 70.9 bits (172), Expect = 8e-12
Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 22/237 (9%)
Query: 223 QAKGLGFSIVGGKDSIY---GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
Q GLG SI GGK S GI++ + G AA G ++ GD++LE+NG ++ G
Sbjct: 734 QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAE 792
Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
H +A++ + A + R R+ P + + PL S ++ L P
Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVT--ITPLRPEDDYS---PRERRGGGLRLP 847
Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAHLDG 397
P + P + V + E G+G I G S PY +GIFV ++ G AH G
Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907
Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDP-----------GPVPIIVSRHPDP 443
L+ GD ++ I+ V + ++L+ P GP+P H P
Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964
Score = 59.7 bits (143), Expect = 2e-08
Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%)
Query: 1112 HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166
HV L + E GLGFS+AGG + I V R+ G A + GT+Q G+ VLSIN
Sbjct: 861 HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919
Query: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 1217
G + H A+++L A P A+++ R+ L P +P + T + A+ S
Sbjct: 920 GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978
Query: 1218 ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 1265
A S ++ V + L + LG S+ G GS H P +
Sbjct: 979 PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036
Query: 1266 -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
+ +G A+ ++ GD IL + G ++ T EA + + P +++++RR
Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091
Score = 51.6 bits (122), Expect = 5e-06
Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%)
Query: 1070 GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 1125
GD +GQ V E + L+ L+ + L + D G+ + K G LG
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112
Query: 1126 FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
S+ GGA D ++ I + +V P G A ++G ++ G +L +N +SL G TH +
Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 1217
A+ +LR V LT +STD+A S
Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203
Score = 49.7 bits (117), Expect = 2e-05
Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYG------PIGIYVKTIFAGGAAAADGRLQEGDEI 267
+ + + K + LG SI GG G GI++ + GAA DGRL+ G +
Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRL 1157
Query: 268 LELNGESMAGLTHQDALQKFKQAKKGLLTL 297
LE+N +S+ GLTH +A+Q + L L
Sbjct: 1158 LEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%)
Query: 1215 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 1270
S A+++ +E + E T+T+ + + GLG S+ GGKGS D+ + I+R+ +
Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767
Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 1300
+ ++ V+ GD++L++ G A+QG EA
Sbjct: 768 PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 80.9 bits (198), Expect = 8e-15
Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%)
Query: 801 NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 860
+R S + L P A+ E G RA+ S ++ S E S P
Sbjct: 443 SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497
Query: 861 RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 914
QP SG PL EE R S G R +A T+ +PE + + EA
Sbjct: 498 ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551
Query: 915 RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 973
G E Q + T+ D LL + EE Q +P R R L R
Sbjct: 552 TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606
Query: 974 SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 1026
+ K K + IS + +LL + P P +P +
Sbjct: 607 TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657
Query: 1027 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 1086
E+ GS + + E R E + +ED +G ++ S SV +
Sbjct: 658 QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709
Query: 1087 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 1141
+ LIE ++ +E + +TIL + GLG S+AGG +++ I +
Sbjct: 710 DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760
Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 1188
RV G A++ G ++ G+++L +NG +L+G HH+A+ LR A EP
Sbjct: 761 SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819
Query: 1189 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 1247
AV +T L PE D S + + ES V L + GLGFS
Sbjct: 820 ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875
Query: 1248 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 1289
+ GGKGS GD + ++RI +G A+ ++ T+Q GD +L + G
Sbjct: 876 IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920
Score = 75.1 bits (183), Expect = 4e-13
Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 17/240 (7%)
Query: 216 NIVLMKGQAKGLGFSIVGGKDSI---YGPIGIYVKTIFAGGAAAADGRLQEGDEILELNG 272
++ + +GLGFSI GGK S G GI+V I GGAA G LQ GD +L +NG
Sbjct: 861 HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920
Query: 273 ESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAPPSLCSHLSPPLCR-SLSSSTCITKD 330
+ H A+ A + L R PPS H SPP + +S T T
Sbjct: 921 VDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980
Query: 331 SSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGL------CSVPYFQCISGIFV 384
+PS + + Y + E+ L + AG LG+ + S P+ G+F+
Sbjct: 981 VPGLPSLAPSLLAAALEGPYPV-EEIRLPR-AGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038
Query: 385 HTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE-VYTILSHCDPGPVPIIVSRHPDP 443
+ P +A G LR GD I+ ++ V T E V +L C + ++V R P P
Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAP 1095
Score = 72.0 bits (175), Expect = 4e-12
Identities = 115/503 (22%), Positives = 180/503 (35%), Gaps = 97/503 (19%)
Query: 227 LGFSIVGGKDSIYGPIGI-----YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
LG SIVGG D P G+ ++ + G AA G L+ GD IL +NG+ + THQ
Sbjct: 1014 LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQ 1072
Query: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341
+A+ + L +L VR R APP L CI K
Sbjct: 1073 EAVSALLRPCLEL-SLLVR-RDPAPPGL-------------RELCIQK------------ 1105
Query: 342 PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRC 401
P R+ + + G G P GIF+ +SP A DGRLR
Sbjct: 1106 -----APGERLGISIR-------GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153
Query: 402 GDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENT 461
G ++E++ + LT E +L ++ + S E + N
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF---EASTDAALEVSPGVIANP 1210
Query: 462 KFGKERHQWSLEGVKRLESS------------------WHGRPTLEKEREKNSAPPHRRA 503
H+ SLE + ++ W T R RA
Sbjct: 1211 FAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRA 1270
Query: 504 QKVMIRSSSDSSYMSGSPGG----SPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIAS 559
+ + S SG+ GG SP S S ++P S ++ A ++ +
Sbjct: 1271 LAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYR-AFAAVPT 1329
Query: 560 SRLPQES---PPLPESRDSHPPLRLK---KSFEILVRKPMSSKPKPPPRKYFKSDSDPQK 613
S P+++ PP P S L + K FE+ VR P + + PP++ +D +
Sbjct: 1330 SHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQA---EGPPKRVSLVGADDLR 1386
Query: 614 SLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSST 673
++E E Q+ ++L + A A G +G + +
Sbjct: 1387 KMQEEEARKLQ---------QKRAQML------REAAEAGAEARLALDGETLGEEEQE-- 1429
Query: 674 EGEPGWRRASPVTQTSPIKHPLL 696
+ +P W SP ++ SP P L
Sbjct: 1430 DEQPPWASPSPTSRQSPASPPPL 1452
Score = 70.9 bits (172), Expect = 8e-12
Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 22/237 (9%)
Query: 223 QAKGLGFSIVGGKDSIY---GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
Q GLG SI GGK S GI++ + G AA G ++ GD++LE+NG ++ G
Sbjct: 734 QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAE 792
Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339
H +A++ + A + R R+ P + + PL S ++ L P
Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVT--ITPLRPEDDYS---PRERRGGGLRLP 847
Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAHLDG 397
P + P + V + E G+G I G S PY +GIFV ++ G AH G
Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907
Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDP-----------GPVPIIVSRHPDP 443
L+ GD ++ I+ V + ++L+ P GP+P H P
Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964
Score = 59.7 bits (143), Expect = 2e-08
Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%)
Query: 1112 HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166
HV L + E GLGFS+AGG + I V R+ G A + GT+Q G+ VLSIN
Sbjct: 861 HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919
Query: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 1217
G + H A+++L A P A+++ R+ L P +P + T + A+ S
Sbjct: 920 GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978
Query: 1218 ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 1265
A S ++ V + L + LG S+ G GS H P +
Sbjct: 979 PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036
Query: 1266 -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
+ +G A+ ++ GD IL + G ++ T EA + + P +++++RR
Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091
Score = 51.6 bits (122), Expect = 5e-06
Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%)
Query: 1070 GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 1125
GD +GQ V E + L+ L+ + L + D G+ + K G LG
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112
Query: 1126 FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
S+ GGA D ++ I + +V P G A ++G ++ G +L +N +SL G TH +
Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 1217
A+ +LR V LT +STD+A S
Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203
Score = 49.7 bits (117), Expect = 2e-05
Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYG------PIGIYVKTIFAGGAAAADGRLQEGDEI 267
+ + + K + LG SI GG G GI++ + GAA DGRL+ G +
Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRL 1157
Query: 268 LELNGESMAGLTHQDALQKFKQAKKGLLTL 297
LE+N +S+ GLTH +A+Q + L L
Sbjct: 1158 LEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%)
Query: 1215 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 1270
S A+++ +E + E T+T+ + + GLG S+ GGKGS D+ + I+R+ +
Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767
Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 1300
+ ++ V+ GD++L++ G A+QG EA
Sbjct: 768 PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 80.1 bits (196), Expect = 1e-14
Identities = 70/246 (28%), Positives = 106/246 (43%), Gaps = 14/246 (5%)
Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
I I L+KG KGLGFSI GG I G IYV I GGAA DG+LQ GD++L +N
Sbjct: 317 IMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325
+ +TH++A+ K K T APP + + S P+ +S S+
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
Query: 326 CITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVH 385
+ + +S A SP + + GLG + + GIF+
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG---GEDGEGIFIS 492
Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445
+ G A L G LR GD I+ ++ + + + L + G IV+++ +
Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEY 550
Query: 446 SEQQLK 451
S + K
Sbjct: 551 SRFEAK 556
Score = 71.6 bits (174), Expect = 5e-12
Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ G A+Q+G ++ + +L +N ++ TH
Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + + RK E + ++ L
Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD++L + ++ +
Sbjct: 323 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382
Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
T EA +K D V + S+ + A D
Sbjct: 383 THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418
Score = 63.9 bits (154), Expect = 1e-09
Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N
Sbjct: 225 ITLERGNS-GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
+ +TH A++ K+A ++ L V+ R
Sbjct: 284 VRDVTHSKAVEALKEA-GSIVRLYVKRR-------------------------------- 310
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
KP ++E+ L K GLG + Q I G I+V + G
Sbjct: 311 ------------KPVSEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
AH DG+L+ GD+++ +++ + +T E T L +
Sbjct: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKN 393
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ TH +A
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387
Query: 1179 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 1215
+ L+ + + + P +M PD+ +S+ + AS
Sbjct: 388 VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443
Query: 1216 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 1271
+ S VS + + V L + S GLGF++ GG+ + + I+ I G
Sbjct: 444 PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499
Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
++ S ++ GD I+ + ++ + +A +K
Sbjct: 500 ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 49.7 bits (117), Expect = 2e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
+LH+ GLGF++ GG D E I + + G A G ++KG+ ++S+N L+ +
Sbjct: 468 VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A A L+ A QAV + + PE
Sbjct: 525 HEQAAAALKNA---GQAVTIVAQYRPE 548
Score = 44.7 bits (104), Expect = 6e-04
Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%)
Query: 1188 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 1247
P + ++ + P + +TDS + + + + E +TLE+ ++GLGFS
Sbjct: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237
Query: 1248 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ GG + H D + I +I G A+ Q ++ D IL++ ++ +T +A +K
Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297
Query: 1306 ALPDGPVTIVIRRKSLQSK 1324
V RRK + K
Sbjct: 298 EAGSIVRLYVKRRKPVSEK 316
Score = 32.0 bits (71), Expect = 4.1
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E++L++ +G+G I G P+ S IF+ + G A DGRLR D I+ +++
Sbjct: 224 EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283
Query: 413 VHCLT 417
V +T
Sbjct: 284 VRDVT 288
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 80.1 bits (196), Expect = 1e-14
Identities = 70/246 (28%), Positives = 106/246 (43%), Gaps = 14/246 (5%)
Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
I I L+KG KGLGFSI GG I G IYV I GGAA DG+LQ GD++L +N
Sbjct: 317 IMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375
Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325
+ +TH++A+ K K T APP + + S P+ +S S+
Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435
Query: 326 CITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVH 385
+ + +S A SP + + GLG + + GIF+
Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG---GEDGEGIFIS 492
Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445
+ G A L G LR GD I+ ++ + + + L + G IV+++ +
Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEY 550
Query: 446 SEQQLK 451
S + K
Sbjct: 551 SRFEAK 556
Score = 71.6 bits (174), Expect = 5e-12
Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ G A+Q+G ++ + +L +N ++ TH
Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + + RK E + ++ L
Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD++L + ++ +
Sbjct: 323 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382
Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
T EA +K D V + S+ + A D
Sbjct: 383 THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418
Score = 63.9 bits (154), Expect = 1e-09
Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N
Sbjct: 225 ITLERGNS-GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
+ +TH A++ K+A ++ L V+ R
Sbjct: 284 VRDVTHSKAVEALKEA-GSIVRLYVKRR-------------------------------- 310
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
KP ++E+ L K GLG + Q I G I+V + G
Sbjct: 311 ------------KPVSEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
AH DG+L+ GD+++ +++ + +T E T L +
Sbjct: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKN 393
Score = 57.0 bits (136), Expect = 1e-07
Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ TH +A
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387
Query: 1179 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 1215
+ L+ + + + P +M PD+ +S+ + AS
Sbjct: 388 VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443
Query: 1216 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 1271
+ S VS + + V L + S GLGF++ GG+ + + I+ I G
Sbjct: 444 PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499
Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
++ S ++ GD I+ + ++ + +A +K
Sbjct: 500 ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 49.7 bits (117), Expect = 2e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
+LH+ GLGF++ GG D E I + + G A G ++KG+ ++S+N L+ +
Sbjct: 468 VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A A L+ A QAV + + PE
Sbjct: 525 HEQAAAALKNA---GQAVTIVAQYRPE 548
Score = 44.7 bits (104), Expect = 6e-04
Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%)
Query: 1188 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 1247
P + ++ + P + +TDS + + + + E +TLE+ ++GLGFS
Sbjct: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237
Query: 1248 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ GG + H D + I +I G A+ Q ++ D IL++ ++ +T +A +K
Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297
Query: 1306 ALPDGPVTIVIRRKSLQSK 1324
V RRK + K
Sbjct: 298 EAGSIVRLYVKRRKPVSEK 316
Score = 32.0 bits (71), Expect = 4.1
Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E++L++ +G+G I G P+ S IF+ + G A DGRLR D I+ +++
Sbjct: 224 EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283
Query: 413 VHCLT 417
V +T
Sbjct: 284 VRDVT 288
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 78.2 bits (191), Expect = 5e-14
Identities = 75/233 (32%), Positives = 101/233 (43%), Gaps = 41/233 (17%)
Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
+ I L KG KGLGFSI GG I G IYV I GGAA DGRLQ GD +L +N
Sbjct: 140 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198
Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325
S+ +TH++A+ K K G T T PP + SPP+ L S
Sbjct: 199 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 258
Query: 326 CITKD-SSSFALESPS--API------------------STAKPNYRIMVEVSLQKE--- 361
T + +S SP +PI +T +P+ + VSL+ E
Sbjct: 259 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRK 318
Query: 362 -----AGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
GLG + + GIFV + G A L G L+ GD+I+ ++
Sbjct: 319 VVLHKGSTGLGFNIVG---GEDGEGIFVSFILAGGPADLSGELQRGDQILSVN 368
Score = 70.5 bits (171), Expect = 1e-11
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ P G A+++G ++ + +L +N + +H
Sbjct: 55 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 114
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + R P L TV + L
Sbjct: 115 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 145
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I G A+++ +Q GD +L + +++ +
Sbjct: 146 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205
Query: 1296 TRFEAWNIIK 1305
T EA I+K
Sbjct: 206 THEEAVAILK 215
Score = 64.7 bits (156), Expect = 6e-10
Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
I L +G + GLGFSI GG D+ I GI++ I GGAAA DGRL+ D IL +N
Sbjct: 48 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
++ ++H A++ K+A ++ L VR R
Sbjct: 107 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 133
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+P +VE+ L K GLG + Q I G I+V + G
Sbjct: 134 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
A DGRL+ GD ++ +++ + +T E IL +
Sbjct: 181 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%)
Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244
TS S +T Q PS LQ +V +VL KG GLGF+IVGG+D GI
Sbjct: 290 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 341
Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
+V I AGG A G LQ GD+IL +NG + G +H+ A K A
Sbjct: 342 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387
Score = 60.1 bits (144), Expect = 1e-08
Identities = 56/239 (23%), Positives = 98/239 (41%), Gaps = 60/239 (25%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+ +L +N SL+ TH +A
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210
Query: 1179 LAILRQARE----------------PRQAVIVTRKLTP-----------------EAMPD 1205
+AIL+ E P +T +P ++P
Sbjct: 211 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP 270
Query: 1206 L-------------------NSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGF 1246
+ + S S A+ + + + E V L K S GLGF
Sbjct: 271 ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF 330
Query: 1247 SLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
++ GG+ + + ++ I G ++ S +Q GD+IL + G ++G + +A +K
Sbjct: 331 NIVGGEDG----EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
+LHK GLGF++ GG D E I V + G A G +Q+G+++LS+NG L+G +
Sbjct: 320 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A A L+ A Q V + + PE
Sbjct: 377 HEQAAAALKGA---GQTVTIIAQYQPE 400
Score = 38.9 bits (89), Expect = 0.033
Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
+TLE+ ++GLGFS+ GG + H GD P + I +I G A+ + ++ D IL++ +
Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107
Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
++ +A +K V + +RR+
Sbjct: 108 SEVSHSKAVEALKE-AGSIVRLYVRRR 133
Score = 35.0 bits (79), Expect = 0.48
Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 3/81 (3%)
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSV 392
A++ P++ + Y E++L++ +G+G I G P+ GIF+ + PG
Sbjct: 28 AMQHAFIPVNGTEIEYEFE-EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGA 86
Query: 393 AHLDGRLRCGDEIVEISDSPV 413
A DGRLR D I+ +++ V
Sbjct: 87 AAEDGRLRVNDCILRVNEVDV 107
>gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens]
Length = 1066
Score = 77.4 bits (189), Expect = 8e-14
Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 38/277 (13%)
Query: 205 PSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-----YGPIGIYVKTIFAGGAAAADG 259
P GG S +++ + LGF+I+GG+ S+ GI+V I G AA +G
Sbjct: 237 PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296
Query: 260 RLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL----LTLTVRTRLTAPPSLCSHLSP 315
LQ D I+E+NG ++ TH A++ FK AK+ + L T RT++ PPS +
Sbjct: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT 356
Query: 316 -----------PLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRI------------ 352
+SS + D E PSA PN I
Sbjct: 357 GTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAH-EYYDPNDYIGDIHQEMDREEL 415
Query: 353 -MVEVSLQK-EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISD 410
+ EV L + + LG+ +C + GI++ + P S+A DGR+R GD I++I+
Sbjct: 416 ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475
Query: 411 SPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
V E +L+ + ++++R P+ Q+ E
Sbjct: 476 IEVQ--NREEAVALLTSEENKNFSLLIAR-PELQLDE 509
Score = 49.3 bits (116), Expect = 2e-05
Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 10/118 (8%)
Query: 1115 ILHKEEGAGLGFSLAGGADL-------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
+LH++ G+ LGF++ GG ++ I V ++ +G A++EG +Q + ++ +NG
Sbjct: 251 VLHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309
Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
+ L TH A+ + A+EP V+ + TP S +D++ E
Sbjct: 310 RDLSRATHDQAVEAFKTAKEP--IVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFE 365
Score = 35.4 bits (80), Expect = 0.37
Identities = 18/74 (24%), Positives = 42/74 (56%), Gaps = 3/74 (4%)
Query: 1124 LGFSLAGGADLENKV-ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAIL 1182
LG ++ D E+ + I + + PN +A+++G I++G+ ++ ING ++ +A+A+L
Sbjct: 431 LGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING--IEVQNREEAVALL 488
Query: 1183 RQAREPRQAVIVTR 1196
++++ R
Sbjct: 489 TSEENKNFSLLIAR 502
Score = 34.3 bits (77), Expect = 0.82
Identities = 23/109 (21%), Positives = 51/109 (46%), Gaps = 6/109 (5%)
Query: 1229 EATVCTVTLEKMSAGLGFSLEGGKGSL-----HGDKPLTINRIFKGAASEQSETVQPGDE 1283
E T+ L + S LGF++ GG+ S+ + + +++I + + +Q D
Sbjct: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303
Query: 1284 ILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
I+++ G + T +A K + P+ + + R++ ++K T +S
Sbjct: 304 IIEVNGRDLSRATHDQAVEAFKTAKE-PIVVQVLRRTPRTKMFTPPSES 351
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 77.0 bits (188), Expect = 1e-13
Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 22/215 (10%)
Query: 211 ASVISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEIL 268
A + I L+KG KGLGFSI GG I G IYV I GGAA DGRLQ GD+IL
Sbjct: 198 AEKVMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
Query: 269 ELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
+N + + H+DA+ K K + + APP + + S L +S
Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 316
Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKE--------AGVGLGIGLCSVP 374
S+ + D + +P++P + ++ E + +E GLG +
Sbjct: 317 HSSYLGTDYPT--AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG-- 372
Query: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
+ GIF+ + G A L G LR GD+I+ ++
Sbjct: 373 -GEDGEGIFISFILAGGPADLSGELRKGDQILSVN 406
Score = 71.6 bits (174), Expect = 5e-12
Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ P G A+Q+G ++ + +L +N ++ TH
Sbjct: 116 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + ++ RK E V + L
Sbjct: 176 AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 206
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD+IL + ++ +
Sbjct: 207 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 266
Query: 1296 TRFEAWNIIK 1305
+A +K
Sbjct: 267 MHEDAVAALK 276
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ H DA
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271
Query: 1179 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 1218
+A L+ + +P A + P+ + D+ S S+
Sbjct: 272 VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 331
Query: 1219 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
A D+ E + + + S GLGF++ GG+ + + I+ I G
Sbjct: 332 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 387
Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
++ S ++ GD+IL + G ++ + +A +K VTI+ + K
Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 436
Score = 60.8 bits (146), Expect = 8e-09
Identities = 71/259 (27%), Positives = 105/259 (40%), Gaps = 64/259 (24%)
Query: 168 SLCSNRKSLSQQLDCPAGKAAGTSRPTRS------LSTAQLVQPSGGLQAS------VIS 215
SL ++K Q D P + + P ++ ++T L P LQ +
Sbjct: 48 SLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYE 107
Query: 216 NIVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N
Sbjct: 108 EITLERGNS-GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166
Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333
+ +TH A++ K+A ++ L V R
Sbjct: 167 DVREVTHSAAVEALKEA-GSIVRLYVMRR------------------------------- 194
Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPG 390
KP ++E+ L K GLG + Q I G I+V + G
Sbjct: 195 -------------KPPAEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 240
Query: 391 SVAHLDGRLRCGDEIVEIS 409
AH DGRL+ GD+I+ ++
Sbjct: 241 GAAHKDGRLQIGDKILAVN 259
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
IV+ +G GLGF+IVGG+D GI++ I AGG A G L++GD+IL +NG +
Sbjct: 357 IVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
Query: 277 GLTHQDALQKFKQA 290
+H+ A K A
Sbjct: 412 NASHEQAAIALKNA 425
Score = 48.9 bits (115), Expect = 3e-05
Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
++H+ GLGF++ GG D E I + + G A G ++KG+++LS+NG L+ +
Sbjct: 358 VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 414
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A L+ A Q V + + PE
Sbjct: 415 HEQAAIALKNA---GQTVTIIAQYKPE 438
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
+TLE+ ++GLGFS+ GG + H GD P + I +I G A+ Q ++ D IL + +
Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168
Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
+ +T A +K V+RRK
Sbjct: 169 REVTHSAAVEALKEAGSIVRLYVMRRK 195
Score = 33.9 bits (76), Expect = 1.1
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E++L++ +G+G I G P+ IF+ + PG A DGRLR D I+ +++
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
V +T + L V + V R P ++K
Sbjct: 168 VREVTHSAAVEALKEAG-SIVRLYVMRRKPPAEKVMEIK 205
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 77.0 bits (188), Expect = 1e-13
Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 22/215 (10%)
Query: 211 ASVISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEIL 268
A + I L+KG KGLGFSI GG I G IYV I GGAA DGRLQ GD+IL
Sbjct: 152 AEKVMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210
Query: 269 ELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
+N + + H+DA+ K K + + APP + + S L +S
Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 270
Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKE--------AGVGLGIGLCSVP 374
S+ + D + +P++P + ++ E + +E GLG +
Sbjct: 271 HSSYLGTDYPT--AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG-- 326
Query: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
+ GIF+ + G A L G LR GD+I+ ++
Sbjct: 327 -GEDGEGIFISFILAGGPADLSGELRKGDQILSVN 360
Score = 71.6 bits (174), Expect = 5e-12
Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ P G A+Q+G ++ + +L +N ++ TH
Sbjct: 70 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + ++ RK E V + L
Sbjct: 130 AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 160
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD+IL + ++ +
Sbjct: 161 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 220
Query: 1296 TRFEAWNIIK 1305
+A +K
Sbjct: 221 MHEDAVAALK 230
Score = 62.8 bits (151), Expect = 2e-09
Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ H DA
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225
Query: 1179 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 1218
+A L+ + +P A + P+ + D+ S S+
Sbjct: 226 VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 285
Query: 1219 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
A D+ E + + + S GLGF++ GG+ + + I+ I G
Sbjct: 286 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 341
Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
++ S ++ GD+IL + G ++ + +A +K VTI+ + K
Sbjct: 342 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 390
Score = 60.5 bits (145), Expect = 1e-08
Identities = 59/198 (29%), Positives = 84/198 (42%), Gaps = 52/198 (26%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N
Sbjct: 63 ITLERGNS-GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
+ +TH A++ K+A ++ L V R
Sbjct: 122 VREVTHSAAVEALKEA-GSIVRLYVMRR-------------------------------- 148
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
KP ++E+ L K GLG + Q I G I+V + G
Sbjct: 149 ------------KPPAEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 195
Query: 392 VAHLDGRLRCGDEIVEIS 409
AH DGRL+ GD+I+ ++
Sbjct: 196 AAHKDGRLQIGDKILAVN 213
Score = 56.2 bits (134), Expect = 2e-07
Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
IV+ +G GLGF+IVGG+D GI++ I AGG A G L++GD+IL +NG +
Sbjct: 311 IVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
Query: 277 GLTHQDALQKFKQA 290
+H+ A K A
Sbjct: 366 NASHEQAAIALKNA 379
Score = 48.9 bits (115), Expect = 3e-05
Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
++H+ GLGF++ GG D E I + + G A G ++KG+++LS+NG L+ +
Sbjct: 312 VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A L+ A Q V + + PE
Sbjct: 369 HEQAAIALKNA---GQTVTIIAQYKPE 392
Score = 42.7 bits (99), Expect = 0.002
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
+TLE+ ++GLGFS+ GG + H GD P + I +I G A+ Q ++ D IL + +
Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122
Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
+ +T A +K V+RRK
Sbjct: 123 REVTHSAAVEALKEAGSIVRLYVMRRK 149
Score = 33.9 bits (76), Expect = 1.1
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E++L++ +G+G I G P+ IF+ + PG A DGRLR D I+ +++
Sbjct: 62 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121
Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451
V +T + L V + V R P ++K
Sbjct: 122 VREVTHSAAVEALKEAG-SIVRLYVMRRKPPAEKVMEIK 159
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 76.3 bits (186), Expect = 2e-13
Identities = 71/235 (30%), Positives = 105/235 (44%), Gaps = 23/235 (9%)
Query: 183 PAGK--AAGTSRPTRSLSTAQLVQPSGGLQASVIS---NIVLMKGQAKGLGFSIVGGKDS 237
P+GK +A S P ST S G I NI L KG +GLGFSI +
Sbjct: 427 PSGKPPSAPASAPQNVFSTTV----SSGYNTKKIGKRLNIQLKKG-TEGLGFSITSRDVT 481
Query: 238 IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAK-KGLLT 296
I G IYVK I GAA DGRL+ GD ++E+NG + G + ++ + + K +G ++
Sbjct: 482 IGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVS 541
Query: 297 LTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEV 356
L V + A P + S I K++ + + P T + + EV
Sbjct: 542 LLVFRQEDA-------FHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTRE---FLTFEV 591
Query: 357 SLQKEAGVGLGIGLCS--VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
L GLG+ + GIFV ++ G A DGRLR D+++ ++
Sbjct: 592 PLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVN 646
Score = 70.9 bits (172), Expect = 8e-12
Identities = 41/122 (33%), Positives = 70/122 (57%), Gaps = 7/122 (5%)
Query: 202 LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-YGPIGIYVKTIFAGGAAAADGR 260
+V G + + + L + GLG S+ G + + +GI+VK+I GGAA+ DGR
Sbjct: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635
Query: 261 LQEGDEILELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLS 314
L+ D+++ +NGES+ G T+QDA++ +++ K+G++ L V R++ L S S
Sbjct: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695
Query: 315 PP 316
PP
Sbjct: 696 PP 697
Score = 66.2 bits (160), Expect = 2e-10
Identities = 57/242 (23%), Positives = 110/242 (45%), Gaps = 25/242 (10%)
Query: 1110 GIHVTILHKEEGAGLGFSLA------GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
G + I K+ GLGFS+ GG+ I V + P G A Q+G ++ G+ ++
Sbjct: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGS----APIYVKNILPRGAAIQDGRLKAGDRLI 512
Query: 1164 SINGKSLKGTTHHDALAILRQAR-EPRQAVIVTRKLTPEAMPDLNS--STDSAASASAAS 1220
+NG L G + + +++LR + E +++V R+ +LN+ S + A
Sbjct: 513 EVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAE 572
Query: 1221 DVSVESTAEATVCTVTLE-----KMSAGLGFSLEGGKG-SLHGDKPLTINRIFKGAASEQ 1274
D + T + T +T E SAGLG S++G + H D + + I G A+ +
Sbjct: 573 DEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASK 632
Query: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------GPVTIVIRRKSLQSKETTA 1328
++ D+++ + G ++ G T +A ++ G + +++ R+ + E +
Sbjct: 633 DGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692
Query: 1329 AG 1330
G
Sbjct: 693 PG 694
Score = 49.3 bits (116), Expect = 2e-05
Identities = 31/99 (31%), Positives = 52/99 (52%), Gaps = 8/99 (8%)
Query: 1095 EEVKVLDEATLKQLDGIHVTI-----LHKEEGAGLGFSLAGGADLENKV---ITVHRVFP 1146
+E K DE + DG + L+ AGLG S+ G EN I V +
Sbjct: 567 KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIIN 626
Query: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185
G AS++G ++ ++++++NG+SL G T+ DA+ LR++
Sbjct: 627 GGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665
Score = 38.5 bits (88), Expect = 0.043
Identities = 61/272 (22%), Positives = 101/272 (37%), Gaps = 71/272 (26%)
Query: 229 FSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFK 288
FS GG+ +G+ VK + GG A + +E D I+ +N + + A F+
Sbjct: 291 FSARGGRT-----LGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFR 345
Query: 289 QAKK------------------------------------------------GLLTLTVR 300
QA + GL T+
Sbjct: 346 QAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRA 405
Query: 301 TRLTAPP------SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMV 354
RL PP S H + P + S+ ++ S + S+ +T K R+ +
Sbjct: 406 PRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTV---SSGYNTKKIGKRLNI 462
Query: 355 EVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVAHLDGRLRCGDEIVEISDS 411
++ K+ GLG + S I G I+V + P A DGRL+ GD ++E++
Sbjct: 463 QL---KKGTEGLGFSITSRDV--TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517
Query: 412 PVHCLTLNEVYTIL-SHCDPGPVPIIVSRHPD 442
+ + EV ++L S G V ++V R D
Sbjct: 518 DLVGKSQEEVVSLLRSTKMEGTVSLLVFRQED 549
>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
Length = 1076
Score = 75.5 bits (184), Expect = 3e-13
Identities = 84/322 (26%), Positives = 140/322 (43%), Gaps = 46/322 (14%)
Query: 1006 PSSISCAQTPCIPKE--GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTE 1063
P + IP+E G++ ++ G + +D +S LR+ G
Sbjct: 33 PDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQ---GGIA 89
Query: 1064 AKED--DDGDHSSLQSG--------QSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHV 1113
A+ D D GD+ +G +ISLL + + ++E L +++ I
Sbjct: 90 ARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFR 149
Query: 1114 TI---LHKEEGAGLGFSLAGGA-DLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSING 1167
T+ LHKE G GF + GGA D NK + + V P G A +EGTI+ G+ +LS++G
Sbjct: 150 TVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208
Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVEST 1227
L GTTH +A++IL+Q + A+++ + S DS A+AS V V T
Sbjct: 209 IRLLGTTHAEAMSILKQCGQ-EAALLIEYDV---------SVMDSVATASGPLLVEVAKT 258
Query: 1228 AEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQL 1287
A++ M + + I++I + +++ + GD IL +
Sbjct: 259 PGASLGVALTTSMCC--------------NKQVIVIDKIKSASIADRCGALHVGDHILSI 304
Query: 1288 GGTAMQGLTRFEAWNIIKALPD 1309
GT+M+ T EA + D
Sbjct: 305 DGTSMEYCTLAEATQFLANTTD 326
Score = 70.5 bits (171), Expect = 1e-11
Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 31/230 (13%)
Query: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
++ G V L K+EG LG +++GG D + K V + G+A++ + G+ + ++
Sbjct: 46 EEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLDVGDYIKAV 104
Query: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
NG +L H + +++L+ E R + V +L P VSV+
Sbjct: 105 NGINLAKFRHDEIISLLKNVGE-RVVLEVEYELPP---------------------VSVQ 142
Query: 1226 -STAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDK----PLTINRIFKGAASEQSETVQP 1280
S+ VTL K GF + GG H D+ P+ I + G +++ T++P
Sbjct: 143 GSSVIFRTVEVTLHKEGNTFGFVIRGGA---HDDRNKSRPVVITCVRPGGPADREGTIKP 199
Query: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330
GD +L + G + G T EA +I+K ++ S+ TA+G
Sbjct: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/244 (20%), Positives = 111/244 (45%), Gaps = 37/244 (15%)
Query: 1088 EELKKLIEEVKVLDEATLK----------QLDGIHVTILHKEEGAGLGFSLAGGADLE-N 1136
EE +L+ + + + TL+ G L K+ LG +++ + +
Sbjct: 486 EEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPG 545
Query: 1137 KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR 1196
+ + + +A + GT++ G+++L+I+ L + DA+ IL+Q + +V
Sbjct: 546 DPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-----LVKL 600
Query: 1197 KLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLH 1256
K+ D ++S + +S A + TV L++ LG ++ G +
Sbjct: 601 KIRK----DEDNSDEQESSG-------------AIIYTVELKRYGGPLGITISGTEEPFD 643
Query: 1257 GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316
P+ I+ + KG +E++ + GD IL + ++++G EA ++++ + VT+ I
Sbjct: 644 ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ-MAGETVTLKI 699
Query: 1317 RRKS 1320
++++
Sbjct: 700 KKQT 703
Score = 48.1 bits (113), Expect = 5e-05
Identities = 69/322 (21%), Positives = 120/322 (37%), Gaps = 54/322 (16%)
Query: 154 MTKKSAAPTDRQPYSLCS-NRKSLSQQLDCPAGKAAGTSRPTRSL---STAQLVQPSGGL 209
+ S +PT YSL S N +L + L + + R + S+ L + GL
Sbjct: 350 LVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGL 409
Query: 210 QASVI----SNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFAGGAAAADGRLQ 262
V+ + +VL G G + G +++ P + I A A G LQ
Sbjct: 410 AGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPP--LISYIEADSPAERCGVLQ 467
Query: 263 EGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
GD ++ +NG T ++A Q + + ++T + L + + P S
Sbjct: 468 IGDRVMAINGIPTEDSTFEEASQLLRDS-----SITSKVTLEIEFDVAESVIP------S 516
Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGI 382
S T V L K+ V LGI + S + +
Sbjct: 517 SGT----------------------------FHVKLPKKHNVELGITISSPSSRKPGDPL 548
Query: 383 FVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD 442
+ + GSVAH G L GD+++ I + + ++ + IL C+ + + R +
Sbjct: 549 VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE--DLVKLKIRKDE 606
Query: 443 PQVSEQQLKEAVAQAVENTKFG 464
EQ+ A+ VE ++G
Sbjct: 607 DNSDEQESSGAIIYTVELKRYG 628
Score = 46.2 bits (108), Expect = 2e-04
Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 24/181 (13%)
Query: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209
A + G +Q G+ V++ING + +T +A +LR + +T K+T E D+
Sbjct: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-------ITSKVTLEIEFDV--- 509
Query: 1210 TDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269
+S +S V + +K + LG ++ GD PL I+ I KG
Sbjct: 510 AESVIPSSGTFHVKLP------------KKHNVELGITISSPSSRKPGD-PLVISDIKKG 556
Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329
+ + ++ T++ GD++L + + + +A I++ D V + IR+ S E ++
Sbjct: 557 SVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-LVKLKIRKDEDNSDEQESS 615
Query: 1330 G 1330
G
Sbjct: 616 G 616
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 10/153 (6%)
Query: 1071 DHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG-IHVTILHKEEGAGLGFSLA 1129
D+ S++ ++ E+L KL + K D + ++ G I T+ K G LG +++
Sbjct: 580 DNCSMEDAVQILQ--QCEDLVKL-KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITIS 636
Query: 1130 GGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPR 1189
G + + +I + + GLA + G I G+ +L+IN SLKG +A+ +L+ A E
Sbjct: 637 GTEEPFDPII-ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-- 693
Query: 1190 QAVIVTRKLTPEAMPDLNSSTDSAASASAASDV 1222
VT K+ + SS +S SD+
Sbjct: 694 ---TVTLKIKKQTDAQSASSPKKFPISSHLSDL 723
Score = 41.6 bits (96), Expect = 0.005
Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%)
Query: 1088 EELKKLIE-EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP 1146
+E LIE +V V+D ++ G + + K GA LG +L +VI + ++
Sbjct: 228 QEAALLIEYDVSVMD--SVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKS 285
Query: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAM--P 1204
+A + G + G+ +LSI+G S++ T +A L + + I+ T A+ P
Sbjct: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGP 345
Query: 1205 DLNSSTDSAASASAASDVSVESTAEATV 1232
D + S+ S ++ S S+ S T+
Sbjct: 346 DHAALVSSSFSPTSMSAYSLSSLNMGTL 373
Score = 37.7 bits (86), Expect = 0.074
Identities = 56/243 (23%), Positives = 93/243 (38%), Gaps = 44/243 (18%)
Query: 187 AAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYV 246
A+ T P +L+ + P ++V+ LMK + LG ++ GG D P V
Sbjct: 27 ASQTKPPDGALAVRRQSIPEEFKGSTVVE---LMKKEGTTLGLTVSGGIDKDGKP---RV 80
Query: 247 KTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAP 306
+ GG AA +L GD I +NG ++A H + + K + ++ L V L
Sbjct: 81 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV-LEVEYEL--- 136
Query: 307 PSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGV-G 365
PP+ S+ S+ I + VEV+L KE G
Sbjct: 137 --------PPV--SVQGSSVIFR-----------------------TVEVTLHKEGNTFG 163
Query: 366 LGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTIL 425
I + + + + PG A +G ++ GD ++ + + T E +IL
Sbjct: 164 FVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223
Query: 426 SHC 428
C
Sbjct: 224 KQC 226
Score = 35.4 bits (80), Expect = 0.37
Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277
V +K LG +I G ++ + PI + ++ GG A G + GD IL +N S+ G
Sbjct: 622 VELKRYGGPLGITISGTEEP-FDPI--IISSLTKGGLAERTGAIHIGDRILAINSSSLKG 678
Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332
+A+ + A + +TL ++ + T S S P+ LS + +DSS
Sbjct: 679 KPLSEAIHLLQMAGE-TVTLKIK-KQTDAQSASSPKKFPISSHLSDLGDVEEDSS 731
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 74.7 bits (182), Expect = 5e-13
Identities = 78/309 (25%), Positives = 128/309 (41%), Gaps = 21/309 (6%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LGFS+ GG ++ GIYVK+I GG AA +G++ +GD +L+++G + GLTH+ A+Q
Sbjct: 938 LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 997
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ + L + R+ S C S + S + + S P P S
Sbjct: 998 LTGPGQ-VARLVLERRVPR--------STQQCPSANDSMGDERTAVSLVTALPGRPSSCV 1048
Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----ISGIFVHTLSPGSVAHLDGRLRCG 402
EV L+K A GLG + C + + L PG A +G + G
Sbjct: 1049 SVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAG 1107
Query: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTK 462
D I+ ++ L EV +L P V +++ R P + E + + + + +
Sbjct: 1108 DIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCRPPPGALPELEQEWQTPELSADKE 1166
Query: 463 FGKERHQWSLEG-VKRLESSWHGRPTLEKE-----REKNSAPPHRRAQKVMIRSSSDSSY 516
F + S + E SW + + R ++S R AQ R +S
Sbjct: 1167 FTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASS 1226
Query: 517 MSGSPGGSP 525
++ SP P
Sbjct: 1227 LTHSPESHP 1235
Score = 72.4 bits (176), Expect = 3e-12
Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%)
Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
I+ L KE+G LGFS+ GG + I V + P G A++EG I +G+ +L ++G
Sbjct: 926 IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984
Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 1222
L G TH A+ L + + V+ R P + S+ DS A +
Sbjct: 985 ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1042
Query: 1223 ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
S S + V L+K + GLGFS +E S + I R+F G +E++
Sbjct: 1043 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1102
Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
+ GD IL + G + +GL E ++++ P VT+++ R
Sbjct: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1143
Score = 52.4 bits (124), Expect = 3e-06
Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
DG + K+ GLGFS + L++ ++ + R+FP A + G I G+ +L
Sbjct: 1052 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1111
Query: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206
++NG+S +G + L +LR A P++ ++ + P A+P+L
Sbjct: 1112 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1152
Score = 48.1 bits (113), Expect = 5e-05
Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 55/300 (18%)
Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
I + L + +G GF I G+ S GI++ +I GG A ++ G +IL LN
Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810
Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI------ 327
S+ G T A++ + + + + +++ + + +SS+ +
Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQG 870
Query: 328 -----TKDSSSFALESPSAPISTAKPNYRIMVE-------------------------VS 357
T+D E A + + P R + V
Sbjct: 871 SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 930
Query: 358 LQKEAGVGLGIGL-----CSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
L KE G LG + SVPY GI+V ++ PG A +G++ GD ++++
Sbjct: 931 LVKEDGT-LGFSVTGGINTSVPY----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVI 985
Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSL 472
+ LT + L+ PG V +V P+ S QQ A N G ER SL
Sbjct: 986 LCGLTHKQAVQCLT--GPGQVARLVLERRVPR-STQQCPSA------NDSMGDERTAVSL 1036
Score = 45.1 bits (105), Expect = 5e-04
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%)
Query: 1232 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 1290
+ VTL++ G GF + G+ S D + I+ I G +E+++T++PG +IL L
Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810
Query: 1291 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 1321
+++G T A +I+ PD I+ + K +
Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 841
Score = 45.1 bits (105), Expect = 5e-04
Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%)
Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
L ++ G GF + G + + I + + P G A + TI+ G ++L++N SL+G
Sbjct: 756 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 815
Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 1216
T + A+ +++ + + + +I K PD SSTD S S
Sbjct: 816 TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 875
Query: 1217 SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 1243
+ D + E A V C + ++SAG
Sbjct: 876 TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 935
Query: 1244 --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301
LGFS+ GG + + + I G + + + GD +LQ+ G + GLT +A
Sbjct: 936 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995
Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
+ ++ RR +++ +A DS
Sbjct: 996 QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1026
Score = 30.8 bits (68), Expect = 9.1
Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Query: 351 RIMVEVSLQKEAGVGLGIGLCSVPYF-QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
R +V V+L+++ G G + Y Q GIF+ ++ PG A ++ G +I+ ++
Sbjct: 749 REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 808
Query: 410 DSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
+ T N ++ + P + +I+S+
Sbjct: 809 HISLEGFTFNMAVRMIQN-SPDNIELIISQ 837
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 74.7 bits (182), Expect = 5e-13
Identities = 78/309 (25%), Positives = 128/309 (41%), Gaps = 21/309 (6%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LGFS+ GG ++ GIYVK+I GG AA +G++ +GD +L+++G + GLTH+ A+Q
Sbjct: 960 LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 1019
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ + L + R+ S C S + S + + S P P S
Sbjct: 1020 LTGPGQ-VARLVLERRVPR--------STQQCPSANDSMGDERTAVSLVTALPGRPSSCV 1070
Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----ISGIFVHTLSPGSVAHLDGRLRCG 402
EV L+K A GLG + C + + L PG A +G + G
Sbjct: 1071 SVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAG 1129
Query: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTK 462
D I+ ++ L EV +L P V +++ R P + E + + + + +
Sbjct: 1130 DIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCRPPPGALPELEQEWQTPELSADKE 1188
Query: 463 FGKERHQWSLEG-VKRLESSWHGRPTLEKE-----REKNSAPPHRRAQKVMIRSSSDSSY 516
F + S + E SW + + R ++S R AQ R +S
Sbjct: 1189 FTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASS 1248
Query: 517 MSGSPGGSP 525
++ SP P
Sbjct: 1249 LTHSPESHP 1257
Score = 72.4 bits (176), Expect = 3e-12
Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%)
Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
I+ L KE+G LGFS+ GG + I V + P G A++EG I +G+ +L ++G
Sbjct: 948 IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 1006
Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 1222
L G TH A+ L + + V+ R P + S+ DS A +
Sbjct: 1007 ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1064
Query: 1223 ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 1276
S S + V L+K + GLGFS +E S + I R+F G +E++
Sbjct: 1065 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1124
Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318
+ GD IL + G + +GL E ++++ P VT+++ R
Sbjct: 1125 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1165
Score = 52.4 bits (124), Expect = 3e-06
Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%)
Query: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163
DG + K+ GLGFS + L++ ++ + R+FP A + G I G+ +L
Sbjct: 1074 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1133
Query: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206
++NG+S +G + L +LR A P++ ++ + P A+P+L
Sbjct: 1134 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1174
Score = 48.1 bits (113), Expect = 5e-05
Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 55/300 (18%)
Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
I + L + +G GF I G+ S GI++ +I GG A ++ G +IL LN
Sbjct: 773 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832
Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI------ 327
S+ G T A++ + + + + +++ + + +SS+ +
Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQG 892
Query: 328 -----TKDSSSFALESPSAPISTAKPNYRIMVE-------------------------VS 357
T+D E A + + P R + V
Sbjct: 893 SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 952
Query: 358 LQKEAGVGLGIGL-----CSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
L KE G LG + SVPY GI+V ++ PG A +G++ GD ++++
Sbjct: 953 LVKEDGT-LGFSVTGGINTSVPY----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVI 1007
Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSL 472
+ LT + L+ PG V +V P+ S QQ A N G ER SL
Sbjct: 1008 LCGLTHKQAVQCLT--GPGQVARLVLERRVPR-STQQCPSA------NDSMGDERTAVSL 1058
Score = 45.1 bits (105), Expect = 5e-04
Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%)
Query: 1232 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 1290
+ VTL++ G GF + G+ S D + I+ I G +E+++T++PG +IL L
Sbjct: 773 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832
Query: 1291 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 1321
+++G T A +I+ PD I+ + K +
Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 863
Score = 45.1 bits (105), Expect = 5e-04
Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%)
Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
L ++ G GF + G + + I + + P G A + TI+ G ++L++N SL+G
Sbjct: 778 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 837
Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 1216
T + A+ +++ + + + +I K PD SSTD S S
Sbjct: 838 TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 897
Query: 1217 SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 1243
+ D + E A V C + ++SAG
Sbjct: 898 TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 957
Query: 1244 --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301
LGFS+ GG + + + I G + + + GD +LQ+ G + GLT +A
Sbjct: 958 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 1017
Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332
+ ++ RR +++ +A DS
Sbjct: 1018 QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1048
Score = 30.8 bits (68), Expect = 9.1
Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Query: 351 RIMVEVSLQKEAGVGLGIGLCSVPYF-QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
R +V V+L+++ G G + Y Q GIF+ ++ PG A ++ G +I+ ++
Sbjct: 771 REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 830
Query: 410 DSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439
+ T N ++ + P + +I+S+
Sbjct: 831 HISLEGFTFNMAVRMIQN-SPDNIELIISQ 859
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 73.9 bits (180), Expect = 9e-13
Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 35/223 (15%)
Query: 1115 ILHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170
I+ + +GLGFS+AGG D ++ I + ++ P G A+ +G + + VL +N +
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 1230
H A+ L++A + V+ R+ PE
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRRRQPPPE----------------------------- 222
Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLG 1288
T+ V L K GLGFS+ GG G+ H GD + I +I +G A+++ +Q GD +L +
Sbjct: 223 TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282
Query: 1289 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331
T +Q + EA +K D V + SL + A D
Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPD 325
Score = 71.6 bits (174), Expect = 5e-12
Identities = 68/221 (30%), Positives = 96/221 (43%), Gaps = 33/221 (14%)
Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
I + L+KG KGLGFSI GG I G IY+ I GGAA DGRLQ GD +L +N
Sbjct: 224 IMEVNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282
Query: 272 GESMAGLTHQDALQKFKQ---------AKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322
++ + H++A+ K AK G L L + APP S + +S
Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHL---NDMYAPPDYASTFTALADNHIS 339
Query: 323 SSTCI----TKDSSSFALESPSAPISTAKPNYRIMV----------EVSLQKEAGVGLGI 368
++ + +S P P + P R M+ ++ L K GLG
Sbjct: 340 HNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHK-GSTGLGF 398
Query: 369 GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
+ + GIFV + G A L G LR GD I+ ++
Sbjct: 399 NIVG---GEDGEGIFVSFILAGGPADLSGELRRGDRILSVN 436
Score = 60.8 bits (146), Expect = 8e-09
Identities = 57/200 (28%), Positives = 88/200 (44%), Gaps = 52/200 (26%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPI--GIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
IVL +G + GLGFSI GG D+ + P GI++ I GGAAA DGRL D +L +N
Sbjct: 132 IVLERGNS-GLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
++ + H A++ K+A ++ L VR R P ++
Sbjct: 191 VSEVVHSRAVEALKEAGP-VVRLVVRRRQPPPETI------------------------- 224
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+EV+L K GLG + Q I G I++ + G
Sbjct: 225 -------------------MEVNLLK-GPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGG 264
Query: 392 VAHLDGRLRCGDEIVEISDS 411
A DGRL+ GD ++ ++++
Sbjct: 265 AAQKDGRLQIGDRLLAVNNT 284
Score = 60.1 bits (144), Expect = 1e-08
Identities = 34/74 (45%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I+L KG GLGF+IVGG+D GI+V I AGG A G L+ GD IL +NG ++
Sbjct: 387 IILHKGST-GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 277 GLTHQDALQKFKQA 290
TH+ A K+A
Sbjct: 442 NATHEQAAAALKRA 455
Score = 54.7 bits (130), Expect = 6e-07
Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 49/235 (20%)
Query: 1123 GLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG + + I + ++ G A ++G +Q G+ +L++N +L+ H +A
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294
Query: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE--------STAEA 1230
+A L+ + + K + D+ + D A++ +A +D + E+
Sbjct: 295 VASLKNTSD--MVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVES 352
Query: 1231 TVC------------------------------TVTLEKMSAGLGFSLEGGKGSLHGDKP 1260
V + L K S GLGF++ GG+ +
Sbjct: 353 KVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG----EG 408
Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIV 1315
+ ++ I G ++ S ++ GD IL + G ++ T +A +K VTIV
Sbjct: 409 IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS-VTIV 462
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
ILHK GLGF++ GG D E I V + G A G +++G+ +LS+NG +L+ T
Sbjct: 388 ILHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A A L++A Q+V + + PE
Sbjct: 445 HEQAAAALKRA---GQSVTIVAQYRPE 468
Score = 36.2 bits (82), Expect = 0.22
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 2/92 (2%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E+ L++ +G+G I G P+ GIF+ + PG A +DGRL D ++ +++
Sbjct: 131 EIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190
Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 444
V + + L P ++ R P P+
Sbjct: 191 VSEVVHSRAVEALKEAGPVVRLVVRRRQPPPE 222
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 73.9 bits (180), Expect = 9e-13
Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)
Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110
+S++ +Y++ + D+ +SS Q Q+ SS K + K D
Sbjct: 1118 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1175
Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
V + + LG S+ GG + + + I V V P G A +G I KG+ VL++NG
Sbjct: 1176 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233
Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215
SL+G TH A+ LR Q+ ++ V VT + T + D N+
Sbjct: 1234 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1290
Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271
+ V S E V L K S+GLGFS + + + ++F G
Sbjct: 1291 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1350
Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ +S + GD IL++ G +++GL++ E + ++
Sbjct: 1351 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384
Score = 71.6 bits (174), Expect = 5e-12
Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ A++
Sbjct: 1187 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1246
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ + V L S S P+ + C D ++ +T
Sbjct: 1247 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1296
Query: 347 KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397
+Y + EV L K + GLG +P S + V L PG A G
Sbjct: 1297 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1355
Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452
++ GD I++++ + + L+ EV + L P V +++ R P P++ L +
Sbjct: 1356 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1414
Query: 453 AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512
+ AQ + N+ K+ Q S V++ SS + + +K P RR S
Sbjct: 1415 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1468
Query: 513 DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569
+ ++ S + S+ + S+ V + P ++E + ++ PQ+ P
Sbjct: 1469 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1526
Query: 570 PESRDSHP 577
PE DS+P
Sbjct: 1527 PEFEDSNP 1534
Score = 58.2 bits (139), Expect = 5e-08
Identities = 44/155 (28%), Positives = 82/155 (52%), Gaps = 9/155 (5%)
Query: 217 IVLMKGQAK-GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
+V +K AK GLGF I+GG+ +GI++ ++ GG A DG L+ GD ++ +N S+
Sbjct: 902 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961
Query: 276 AGLTHQDALQKFKQAKKGLLTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332
G++H A++ + A + +TL + + +++ PS HL+ + + S+ + +DS
Sbjct: 962 EGVSHHAAIEILQNAPED-VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS- 1018
Query: 333 SFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLG 367
A++S S ++ R + E S G+ G
Sbjct: 1019 --AIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1051
Score = 52.8 bits (125), Expect = 2e-06
Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N +
Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
+TH DA+ + A K TVR + L
Sbjct: 1653 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1678
Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++
Sbjct: 1679 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1731
Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
G L+ D I ++ +TL EV L P V + +R+ P V K +
Sbjct: 1732 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1788
Query: 457 AVENTK 462
A ++TK
Sbjct: 1789 APKSTK 1794
Score = 52.4 bits (124), Expect = 3e-06
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)
Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
L K+ GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G
Sbjct: 905 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964
Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228
+HH A+ IL+ A E VI K +P N + +S D +++S++
Sbjct: 965 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1024
Query: 1229 E 1229
+
Sbjct: 1025 K 1025
Score = 48.9 bits (115), Expect = 3e-05
Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ +
Sbjct: 1702 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1759
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ L+ R L PS RS S+ TK + S+++ S S P T
Sbjct: 1760 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1811
Query: 347 KPNY 350
++
Sbjct: 1812 NDSF 1815
Score = 44.3 bits (103), Expect = 8e-04
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG
Sbjct: 891 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 950
Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
D ++ + +++G++ A I++ P+ ++ + K SK
Sbjct: 951 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 993
Score = 41.2 bits (95), Expect = 0.007
Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%)
Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414
V+L+K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ +
Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962
Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
++ + IL + P V +++S+ P ++S+
Sbjct: 963 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 993
Score = 40.8 bits (94), Expect = 0.009
Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
+KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T
Sbjct: 1698 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
+ L + + K T +P + SS SA SA
Sbjct: 1755 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1789
Score = 39.7 bits (91), Expect = 0.020
Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)
Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
+T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N +
Sbjct: 1598 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1653
Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
TH DA+ +LR A + + VI + P +PD+
Sbjct: 1654 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1693
Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
T+T K LGFSL GG SL+ + + I+ I + + +Q D I
Sbjct: 1694 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1742
Query: 1287 LGGTAMQGLT 1296
+ G + QG+T
Sbjct: 1743 VNGVSTQGMT 1752
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/91 (23%), Positives = 40/91 (43%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294
V L K LG S+ GG + + + + A+E + GD +L + G +++G
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237
Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
T +A ++ ++ + +S SKE
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1268
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 73.9 bits (180), Expect = 9e-13
Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)
Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110
+S++ +Y++ + D+ +SS Q Q+ SS K + K D
Sbjct: 1309 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1366
Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
V + + LG S+ GG + + + I V V P G A +G I KG+ VL++NG
Sbjct: 1367 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1424
Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215
SL+G TH A+ LR Q+ ++ V VT + T + D N+
Sbjct: 1425 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1481
Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271
+ V S E V L K S+GLGFS + + + ++F G
Sbjct: 1482 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1541
Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ +S + GD IL++ G +++GL++ E + ++
Sbjct: 1542 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575
Score = 71.6 bits (174), Expect = 5e-12
Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ A++
Sbjct: 1378 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1437
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ + V L S S P+ + C D ++ +T
Sbjct: 1438 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1487
Query: 347 KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397
+Y + EV L K + GLG +P S + V L PG A G
Sbjct: 1488 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546
Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452
++ GD I++++ + + L+ EV + L P V +++ R P P++ L +
Sbjct: 1547 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1605
Query: 453 AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512
+ AQ + N+ K+ Q S V++ SS + + +K P RR S
Sbjct: 1606 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1659
Query: 513 DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569
+ ++ S + S+ + S+ V + P ++E + ++ PQ+ P
Sbjct: 1660 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1717
Query: 570 PESRDSHP 577
PE DS+P
Sbjct: 1718 PEFEDSNP 1725
Score = 58.5 bits (140), Expect = 4e-08
Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 26/256 (10%)
Query: 126 LFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPA- 184
L K HQ +RS++ S+ KS A +R P +S S ++ P
Sbjct: 999 LVGKPSHQMSRSDAESLAGVTKLN-----NSKSVASLNRSPER--RKHESDSSSIEDPGQ 1051
Query: 185 GKAAGTSRPTRSLSTAQLVQPSGGL---QASVISN------IVLMKGQAK-GLGFSIVGG 234
G + + S++Q+ + + S++S+ +V +K AK GLGF I+GG
Sbjct: 1052 AYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111
Query: 235 KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL 294
+ +GI++ ++ GG A DG L+ GD ++ +N S+ G++H A++ + A +
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPED- 1170
Query: 295 LTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYR 351
+TL + + +++ PS HL+ + + S+ + +DS A++S S ++ R
Sbjct: 1171 VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS---AIDSSSKDHHWSRGTLR 1226
Query: 352 IMVEVSLQKEAGVGLG 367
+ E S G+ G
Sbjct: 1227 HISENSFGPSGGLREG 1242
Score = 52.8 bits (125), Expect = 2e-06
Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N +
Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
+TH DA+ + A K TVR + L
Sbjct: 1844 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1869
Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++
Sbjct: 1870 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1922
Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
G L+ D I ++ +TL EV L P V + +R+ P V K +
Sbjct: 1923 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1979
Query: 457 AVENTK 462
A ++TK
Sbjct: 1980 APKSTK 1985
Score = 52.4 bits (124), Expect = 3e-06
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)
Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
L K+ GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228
+HH A+ IL+ A E VI K +P N + +S D +++S++
Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215
Query: 1229 E 1229
+
Sbjct: 1216 K 1216
Score = 48.9 bits (115), Expect = 3e-05
Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ +
Sbjct: 1893 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1950
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ L+ R L PS RS S+ TK + S+++ S S P T
Sbjct: 1951 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2002
Query: 347 KPNY 350
++
Sbjct: 2003 NDSF 2006
Score = 44.3 bits (103), Expect = 8e-04
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141
Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
D ++ + +++G++ A I++ P+ ++ + K SK
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184
Score = 41.2 bits (95), Expect = 0.007
Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%)
Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414
V+L+K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
++ + IL + P V +++S+ P ++S+
Sbjct: 1154 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 1184
Score = 40.8 bits (94), Expect = 0.009
Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
+KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T
Sbjct: 1889 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
+ L + + K T +P + SS SA SA
Sbjct: 1946 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1980
Score = 39.7 bits (91), Expect = 0.020
Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)
Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
+T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N +
Sbjct: 1789 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1844
Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
TH DA+ +LR A + + VI + P +PD+
Sbjct: 1845 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1884
Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
T+T K LGFSL GG SL+ + + I+ I + + +Q D I
Sbjct: 1885 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1933
Query: 1287 LGGTAMQGLT 1296
+ G + QG+T
Sbjct: 1934 VNGVSTQGMT 1943
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/91 (23%), Positives = 40/91 (43%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294
V L K LG S+ GG + + + + A+E + GD +L + G +++G
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428
Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
T +A ++ ++ + +S SKE
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1459
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 73.9 bits (180), Expect = 9e-13
Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%)
Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110
+S++ +Y++ + D+ +SS Q Q+ SS K + K D
Sbjct: 1290 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1347
Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
V + + LG S+ GG + + + I V V P G A +G I KG+ VL++NG
Sbjct: 1348 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405
Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215
SL+G TH A+ LR Q+ ++ V VT + T + D N+
Sbjct: 1406 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1462
Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271
+ V S E V L K S+GLGFS + + + ++F G
Sbjct: 1463 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1522
Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+ +S + GD IL++ G +++GL++ E + ++
Sbjct: 1523 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556
Score = 71.6 bits (174), Expect = 5e-12
Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ A++
Sbjct: 1359 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1418
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ + V L S S P+ + C D ++ +T
Sbjct: 1419 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1468
Query: 347 KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397
+Y + EV L K + GLG +P S + V L PG A G
Sbjct: 1469 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1527
Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452
++ GD I++++ + + L+ EV + L P V +++ R P P++ L +
Sbjct: 1528 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1586
Query: 453 AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512
+ AQ + N+ K+ Q S V++ SS + + +K P RR S
Sbjct: 1587 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1640
Query: 513 DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569
+ ++ S + S+ + S+ V + P ++E + ++ PQ+ P
Sbjct: 1641 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1698
Query: 570 PESRDSHP 577
PE DS+P
Sbjct: 1699 PEFEDSNP 1706
Score = 58.2 bits (139), Expect = 5e-08
Identities = 44/155 (28%), Positives = 82/155 (52%), Gaps = 9/155 (5%)
Query: 217 IVLMKGQAK-GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
+V +K AK GLGF I+GG+ +GI++ ++ GG A DG L+ GD ++ +N S+
Sbjct: 1074 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133
Query: 276 AGLTHQDALQKFKQAKKGLLTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332
G++H A++ + A + +TL + + +++ PS HL+ + + S+ + +DS
Sbjct: 1134 EGVSHHAAIEILQNAPED-VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS- 1190
Query: 333 SFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLG 367
A++S S ++ R + E S G+ G
Sbjct: 1191 --AIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1223
Score = 53.9 bits (128), Expect = 1e-06
Identities = 47/179 (26%), Positives = 84/179 (46%), Gaps = 22/179 (12%)
Query: 1073 SSLQSGQSVISLLSSEELKKL-IEEVKVLDEATLKQLDGIH------------VTILHKE 1119
+ L + +SV SL S E +K + + D LD +H +T+++ +
Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078
Query: 1120 EGA--GLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
+ A GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G +H
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138
Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTAE 1229
H A+ IL+ A E VI K +P N + +S D +++S+++
Sbjct: 1139 HAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSK 1197
Score = 52.8 bits (125), Expect = 2e-06
Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N +
Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
+TH DA+ + A K TVR + L
Sbjct: 1825 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1850
Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++
Sbjct: 1851 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1903
Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
G L+ D I ++ +TL EV L P V + +R+ P V K +
Sbjct: 1904 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1960
Query: 457 AVENTK 462
A ++TK
Sbjct: 1961 APKSTK 1966
Score = 48.9 bits (115), Expect = 3e-05
Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ +
Sbjct: 1874 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1931
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ L+ R L PS RS S+ TK + S+++ S S P T
Sbjct: 1932 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1983
Query: 347 KPNY 350
++
Sbjct: 1984 NDSF 1987
Score = 45.4 bits (106), Expect = 4e-04
Identities = 38/149 (25%), Positives = 73/149 (48%), Gaps = 4/149 (2%)
Query: 301 TRLTAPPSLCS-HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQ 359
T+L S+ S + SP + S S+ I ++ L+ S R + V+L+
Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078
Query: 360 KEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTL 418
K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ + ++
Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138
Query: 419 NEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
+ IL + P V +++S+ P ++S+
Sbjct: 1139 HAAIEILQNA-PEDVTLVISQ-PKEKISK 1165
Score = 44.3 bits (103), Expect = 8e-04
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG
Sbjct: 1063 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122
Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
D ++ + +++G++ A I++ P+ ++ + K SK
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1165
Score = 40.8 bits (94), Expect = 0.009
Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
+KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T
Sbjct: 1870 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
+ L + + K T +P + SS SA SA
Sbjct: 1927 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1961
Score = 39.7 bits (91), Expect = 0.020
Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)
Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
+T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N +
Sbjct: 1770 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1825
Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
TH DA+ +LR A + + VI + P +PD+
Sbjct: 1826 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1865
Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
T+T K LGFSL GG SL+ + + I+ I + + +Q D I
Sbjct: 1866 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1914
Query: 1287 LGGTAMQGLT 1296
+ G + QG+T
Sbjct: 1915 VNGVSTQGMT 1924
Score = 33.5 bits (75), Expect = 1.4
Identities = 21/91 (23%), Positives = 40/91 (43%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294
V L K LG S+ GG + + + + A+E + GD +L + G +++G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409
Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
T +A ++ ++ + +S SKE
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1440
>gi|157388993 synaptojanin 2 binding protein [Homo sapiens]
Length = 145
Score = 73.6 bits (179), Expect = 1e-12
Identities = 42/80 (52%), Positives = 52/80 (65%), Gaps = 3/80 (3%)
Query: 226 GLGFSIVGGKDSIY--GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
GLGF+IVGG D Y GIYV I GAAA DGRLQEGD+IL +NG+ + L HQDA
Sbjct: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81
Query: 284 LQKFKQAKKGLLTLTVRTRL 303
+ F+ A ++L V+ RL
Sbjct: 82 VDLFRNAGYA-VSLRVQHRL 100
Score = 56.6 bits (135), Expect = 2e-07
Identities = 27/68 (39%), Positives = 44/68 (64%), Gaps = 4/68 (5%)
Query: 1122 AGLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGF++ GG D + + I V R+ NG A+ +G +Q+G+++LS+NG+ LK H D
Sbjct: 21 SGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQD 80
Query: 1178 ALAILRQA 1185
A+ + R A
Sbjct: 81 AVDLFRNA 88
Score = 32.0 bits (71), Expect = 4.1
Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409
E++L + +G+G I G Y SGI+V + A LDGRL+ GD+I+ ++
Sbjct: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVN 69
>gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens]
Length = 1141
Score = 72.4 bits (176), Expect = 3e-12
Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 27/194 (13%)
Query: 1119 EEGAGLGFSLAGGADLE---NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175
+EG GF L GGA + ++ + + V P G A +EG+++ G+ +LS++G L G +H
Sbjct: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309
Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTV 1235
ALA LRQ + TP D+ A+AS V + T
Sbjct: 310 ATALATLRQCSHEALFQVEYDVATP----------DTVANASGPLMVEIVKTP------- 352
Query: 1236 TLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
+ LG SL SL +TI+RI + ++S + PGD IL + GT+M+
Sbjct: 353 -----GSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405
Query: 1296 TRFEAWNIIKALPD 1309
+ EA ++ ++ +
Sbjct: 406 SLLEATKLLASISE 419
Score = 63.9 bits (154), Expect = 1e-09
Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 22/196 (11%)
Query: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165
++ GI V L K+EG+ LG +++GG D + K V + P GLA++ + G+ + S+
Sbjct: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196
Query: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225
NG L H + + +L+ E R + V +L P A P+ N +
Sbjct: 197 NGIHLTRLRHDEIITLLKNVGE-RVVLEVEYELPPPA-PENNPRI-------------IS 241
Query: 1226 STAEATVCTVTLEKMSAGLGFSLEGG-KGSLHGDKPLTINRIFKGAASEQSETVQPGDEI 1284
T + V+L K GF L GG H +PL + + G +++ +++ GD +
Sbjct: 242 KTVD-----VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296
Query: 1285 LQLGGTAMQGLTRFEA 1300
L + G + G + A
Sbjct: 297 LSVDGIPLHGASHATA 312
Score = 51.6 bits (122), Expect = 5e-06
Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 28/229 (12%)
Query: 1092 KLIEEVKV-LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLA 1150
K++ EV+ + E+ + HV L K+ LG +++ + + + + + +A
Sbjct: 634 KVVLEVEFDVAESVIPSSGTFHVK-LPKKRSVELGITISSASRKRGEPLIISDIKKGSVA 692
Query: 1151 SQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSST 1210
+ GT++ G+++L+I+ L DA+ ILRQ + +V K+ + ++
Sbjct: 693 HRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED-----LVKLKIRKD-----EDNS 742
Query: 1211 DSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGA 1270
D + A S TV L++ LG ++ G + P+ I+ + K
Sbjct: 743 DELETTGAVS------------YTVELKRYGGPLGITISGTEEPF---DPIVISGLTKRG 787
Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319
+E++ + GD IL + +++G EA ++++ + VT+ I+++
Sbjct: 788 LAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGE-TVTLKIKKQ 835
Score = 49.3 bits (116), Expect = 2e-05
Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%)
Query: 1122 AGLGFSLAGGADLENKVIT---VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
+G G L GG + + V + P+ A + G +Q G+ VLSING + + T +A
Sbjct: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622
Query: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLE 1238
+LR A + V L D A S +S T +
Sbjct: 623 NQLLRDAALAHKVV-------------LEVEFDVAESVIPSS---------GTFHVKLPK 660
Query: 1239 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 1298
K S LG ++ S +PL I+ I KG+ + ++ T++PGD++L + +
Sbjct: 661 KRSVELGITI--SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718
Query: 1299 EAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330
+A I++ D V + IR+ S E G
Sbjct: 719 DAVQILRQCED-LVKLKIRKDEDNSDELETTG 749
Score = 43.5 bits (101), Expect = 0.001
Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 53/275 (19%)
Query: 201 QLVQPSGGLQASVISNIVLMKGQAKGLGFSIV---GGKDSIYGPIGIYVKTIFAGGAAAA 257
+L P+ +IS V + +G F V G + + + + + GG A
Sbjct: 227 ELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADR 286
Query: 258 DGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPL 317
+G L+ GD +L ++G + G +H AL +Q CSH
Sbjct: 287 EGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------------------CSH----- 321
Query: 318 CRSLSSSTCITKDSSSFALESPSA-PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYF 376
+ F +E A P + A + +MVE+ K G LGI L +
Sbjct: 322 -------------EALFQVEYDVATPDTVANASGPLMVEIV--KTPGSALGISLTTTS-L 365
Query: 377 QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV-HCLTLNEVYTILSHCDPGPVPI 435
+ S I + + P SV G L GD I+ I + + HC L + S + + I
Sbjct: 366 RNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425
Query: 436 IVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQW 470
+ P PQ S++ L+ + V + ++ H+W
Sbjct: 426 L----PVPQ-SQRPLRP--QRQVVKVQRSEQLHRW 453
Score = 41.2 bits (95), Expect = 0.007
Identities = 25/92 (27%), Positives = 43/92 (46%)
Query: 1096 EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 1155
E V T+ G + + K G+ LG SL + VIT+ R+ P + + G
Sbjct: 328 EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGA 387
Query: 1156 IQKGNEVLSINGKSLKGTTHHDALAILRQARE 1187
+ G+ +LSI+G S++ + +A +L E
Sbjct: 388 LHPGDHILSIDGTSMEHCSLLEATKLLASISE 419
Score = 39.7 bits (91), Expect = 0.020
Identities = 63/273 (23%), Positives = 101/273 (36%), Gaps = 48/273 (17%)
Query: 196 SLSTAQ-LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFA 251
SLS A V P G + + + +VL G G + GG +++ P V I
Sbjct: 533 SLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPP--LVCFIEP 590
Query: 252 GGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCS 311
A G LQ GD +L +NG + T ++A Q + A L + L +
Sbjct: 591 DSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDA-----ALAHKVVLEVEFDVAE 645
Query: 312 HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC 371
+ P SS T V L K+ V LGI +
Sbjct: 646 SVIP------SSGT----------------------------FHVKLPKKRSVELGITIS 671
Query: 372 SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPG 431
S + + + + GSVAH G L GD+++ I + + + + IL C+
Sbjct: 672 SASRKRG-EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCE-- 728
Query: 432 PVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFG 464
+ + R + E + AV+ VE ++G
Sbjct: 729 DLVKLKIRKDEDNSDELETTGAVSYTVELKRYG 761
Score = 36.2 bits (82), Expect = 0.22
Identities = 51/217 (23%), Positives = 78/217 (35%), Gaps = 42/217 (19%)
Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273
I+ + L+K + LG +I GG D P V + GG AA L GD I +NG
Sbjct: 143 ITVVELIKKEGSTLGLTISGGTDKDGKP---RVSNLRPGGLAARSDLLNIGDYIRSVNGI 199
Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333
+ L H + + K + ++ L V L P +P + S T
Sbjct: 200 HLTRLRHDEIITLLKNVGERVV-LEVEYELPPP-------APENNPRIISKT-------- 243
Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG--IFVHTLSPGS 391
V+VSL KE G G L + + + + PG
Sbjct: 244 --------------------VDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGG 282
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428
A +G L+ GD ++ + P+H + L C
Sbjct: 283 PADREGSLKVGDRLLSVDGIPLHGASHATALATLRQC 319
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 71.2 bits (173), Expect = 6e-12
Identities = 59/213 (27%), Positives = 93/213 (43%), Gaps = 28/213 (13%)
Query: 1110 GIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 1169
GI VT+L + G G I V V P G A +G I KG+ VL++NG S
Sbjct: 1379 GISVTVLFDKGGVNTSVRHGG--------IYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1430
Query: 1170 LKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
L+G TH A+ LR Q+ ++ V VT + T + D N+
Sbjct: 1431 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEKV 1487
Query: 1217 SAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAAS 1272
+ V S E V L K S+GLGFS + + + ++F G +
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547
Query: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
+S + GD IL++ G +++GL++ E + ++
Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580
Score = 65.5 bits (158), Expect = 3e-10
Identities = 91/373 (24%), Positives = 156/373 (41%), Gaps = 42/373 (11%)
Query: 227 LGFSIV-----GGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281
LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+
Sbjct: 1378 LGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1437
Query: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341
A++ + + V L S S P+ + C D ++
Sbjct: 1438 QAVETLRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKV 1487
Query: 342 PISTAKPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSV 392
+T +Y + EV L K + GLG +P S + V L PG
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1546
Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQ 449
A G++ GD I++++ + + L+ EV + L P V +++ R P P++
Sbjct: 1547 AAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTAL 1605
Query: 450 LK--EAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVM 507
L ++ AQ + N+ K+ Q S V++ SS + + +K P RR
Sbjct: 1606 LTPLQSPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSD 1659
Query: 508 IRSSSDSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQ 564
S + ++ S + S+ + S+ V + P ++E + ++ PQ
Sbjct: 1660 SSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQ 1717
Query: 565 ESPPLPESRDSHP 577
+ P PE DS+P
Sbjct: 1718 KIPNKPEFEDSNP 1730
Score = 58.5 bits (140), Expect = 4e-08
Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 26/256 (10%)
Query: 126 LFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPA- 184
L K HQ +RS++ S+ KS A +R P +S S ++ P
Sbjct: 999 LVGKPSHQMSRSDAESLAGVTKLN-----NSKSVASLNRSPER--RKHESDSSSIEDPGQ 1051
Query: 185 GKAAGTSRPTRSLSTAQLVQPSGGL---QASVISN------IVLMKGQAK-GLGFSIVGG 234
G + + S++Q+ + + S++S+ +V +K AK GLGF I+GG
Sbjct: 1052 AYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111
Query: 235 KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL 294
+ +GI++ ++ GG A DG L+ GD ++ +N S+ G++H A++ + A +
Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPED- 1170
Query: 295 LTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYR 351
+TL + + +++ PS HL+ + + S+ + +DS A++S S ++ R
Sbjct: 1171 VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS---AIDSSSKDHHWSRGTLR 1226
Query: 352 IMVEVSLQKEAGVGLG 367
+ E S G+ G
Sbjct: 1227 HISENSFGPSGGLREG 1242
Score = 52.8 bits (125), Expect = 2e-06
Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%)
Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276
I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N +
Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848
Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336
+TH DA+ + A K TVR + L
Sbjct: 1849 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1874
Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396
E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++
Sbjct: 1875 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1927
Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456
G L+ D I ++ +TL EV L P V + +R+ P V K +
Sbjct: 1928 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1984
Query: 457 AVENTK 462
A ++TK
Sbjct: 1985 APKSTK 1990
Score = 52.4 bits (124), Expect = 3e-06
Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%)
Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173
L K+ GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228
+HH A+ IL+ A E VI K +P N + +S D +++S++
Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215
Query: 1229 E 1229
+
Sbjct: 1216 K 1216
Score = 48.9 bits (115), Expect = 3e-05
Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%)
Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286
LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ +
Sbjct: 1898 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1955
Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346
+ L+ R L PS RS S+ TK + S+++ S S P T
Sbjct: 1956 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2007
Query: 347 KPNY 350
++
Sbjct: 2008 NDSF 2011
Score = 44.3 bits (103), Expect = 8e-04
Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281
S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141
Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324
D ++ + +++G++ A I++ P+ ++ + K SK
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184
Score = 41.2 bits (95), Expect = 0.007
Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%)
Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414
V+L+K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ +
Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153
Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447
++ + IL + P V +++S+ P ++S+
Sbjct: 1154 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 1184
Score = 40.8 bits (94), Expect = 0.009
Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%)
Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176
+KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T
Sbjct: 1894 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216
+ L + + K T +P + SS SA SA
Sbjct: 1951 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1985
Score = 39.7 bits (91), Expect = 0.020
Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%)
Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
+T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N +
Sbjct: 1794 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1849
Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
TH DA+ +LR A + + VI + P +PD+
Sbjct: 1850 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1889
Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286
T+T K LGFSL GG SL+ + + I+ I + + +Q D I
Sbjct: 1890 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1938
Query: 1287 LGGTAMQGLT 1296
+ G + QG+T
Sbjct: 1939 VNGVSTQGMT 1948
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 70.5 bits (171), Expect = 1e-11
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ P G A+++G ++ + +L +N + +H
Sbjct: 211 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 270
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + R P L TV + L
Sbjct: 271 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 301
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I G A+++ +Q GD +L + +++ +
Sbjct: 302 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 361
Query: 1296 TRFEAWNIIK 1305
T EA I+K
Sbjct: 362 THEEAVAILK 371
Score = 68.2 bits (165), Expect = 5e-11
Identities = 48/118 (40%), Positives = 58/118 (49%), Gaps = 9/118 (7%)
Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
+ I L KG KGLGFSI GG I G IYV I GGAA DGRLQ GD +L +N
Sbjct: 296 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354
Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323
S+ +TH++A+ K K G T T PP + SPP+ L S
Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 412
Score = 64.7 bits (156), Expect = 6e-10
Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
I L +G + GLGFSI GG D+ I GI++ I GGAAA DGRL+ D IL +N
Sbjct: 204 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
++ ++H A++ K+A ++ L VR R
Sbjct: 263 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 289
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+P +VE+ L K GLG + Q I G I+V + G
Sbjct: 290 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 336
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
A DGRL+ GD ++ +++ + +T E IL +
Sbjct: 337 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 372
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%)
Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244
TS S +T Q PS LQ +V +VL KG GLGF+IVGG+D GI
Sbjct: 498 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 549
Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
+V I AGG A G LQ GD+IL +NG + G +H+ A K A
Sbjct: 550 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
+LHK GLGF++ GG D E I V + G A G +Q+G+++LS+NG L+G +
Sbjct: 528 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A A L+ A Q V + + PE
Sbjct: 585 HEQAAAALKGA---GQTVTIIAQYQPE 608
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+ +L +N SL+ TH +A
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366
Query: 1179 LAILRQARE 1187
+AIL+ E
Sbjct: 367 VAILKNTSE 375
Score = 38.9 bits (89), Expect = 0.033
Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
+TLE+ ++GLGFS+ GG + H GD P + I +I G A+ + ++ D IL++ +
Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263
Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
++ +A +K V + +RR+
Sbjct: 264 SEVSHSKAVEALKE-AGSIVRLYVRRR 289
Score = 38.5 bits (88), Expect = 0.043
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%)
Query: 1209 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268
S S A+ + + + E V L K S GLGF++ GG+ + + ++ I
Sbjct: 501 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 556
Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
G ++ S +Q GD+IL + G ++G + +A +K
Sbjct: 557 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593
Score = 33.9 bits (76), Expect = 1.1
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E++L++ +G+G I G P+ GIF+ + PG A DGRLR D I+ +++
Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262
Query: 413 V 413
V
Sbjct: 263 V 263
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 70.5 bits (171), Expect = 1e-11
Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%)
Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177
+GLGFS+AGG D ++ I + ++ P G A+++G ++ + +L +N + +H
Sbjct: 106 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 165
Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237
A+ L++A + R P L TV + L
Sbjct: 166 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 196
Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295
K GLGFS+ GG G+ H GD + + +I G A+++ +Q GD +L + +++ +
Sbjct: 197 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 256
Query: 1296 TRFEAWNIIK 1305
T EA I+K
Sbjct: 257 THEEAVAILK 266
Score = 68.2 bits (165), Expect = 5e-11
Identities = 48/118 (40%), Positives = 58/118 (49%), Gaps = 9/118 (7%)
Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271
+ I L KG KGLGFSI GG I G IYV I GGAA DGRLQ GD +L +N
Sbjct: 191 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249
Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323
S+ +TH++A+ K K G T T PP + SPP+ L S
Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 307
Score = 64.7 bits (156), Expect = 6e-10
Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%)
Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274
I L +G + GLGFSI GG D+ I GI++ I GGAAA DGRL+ D IL +N
Sbjct: 99 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157
Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334
++ ++H A++ K+A ++ L VR R
Sbjct: 158 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 184
Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+P +VE+ L K GLG + Q I G I+V + G
Sbjct: 185 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 231
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427
A DGRL+ GD ++ +++ + +T E IL +
Sbjct: 232 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 267
Score = 63.5 bits (153), Expect = 1e-09
Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%)
Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244
TS S +T Q PS LQ +V +VL KG GLGF+IVGG+D GI
Sbjct: 393 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 444
Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290
+V I AGG A G LQ GD+IL +NG + G +H+ A K A
Sbjct: 445 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 490
Score = 54.7 bits (130), Expect = 6e-07
Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174
+LHK GLGF++ GG D E I V + G A G +Q+G+++LS+NG L+G +
Sbjct: 423 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479
Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201
H A A L+ A Q V + + PE
Sbjct: 480 HEQAAAALKGA---GQTVTIIAQYQPE 503
Score = 50.4 bits (119), Expect = 1e-05
Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%)
Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178
GLGFS+AGG ++ I V ++ G A ++G +Q G+ +L +N SL+ TH +A
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261
Query: 1179 LAILRQARE 1187
+AIL+ E
Sbjct: 262 VAILKNTSE 270
Score = 38.9 bits (89), Expect = 0.033
Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%)
Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292
+TLE+ ++GLGFS+ GG + H GD P + I +I G A+ + ++ D IL++ +
Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158
Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319
++ +A +K V + +RR+
Sbjct: 159 SEVSHSKAVEALKE-AGSIVRLYVRRR 184
Score = 38.5 bits (88), Expect = 0.043
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%)
Query: 1209 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268
S S A+ + + + E V L K S GLGF++ GG+ + + ++ I
Sbjct: 396 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 451
Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305
G ++ S +Q GD+IL + G ++G + +A +K
Sbjct: 452 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488
Score = 33.9 bits (76), Expect = 1.1
Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 2/61 (3%)
Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412
E++L++ +G+G I G P+ GIF+ + PG A DGRLR D I+ +++
Sbjct: 98 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157
Query: 413 V 413
V
Sbjct: 158 V 158
>gi|119120897 par-3 partitioning defective 3 homolog B isoform b
[Homo sapiens]
Length = 1143
Score = 67.8 bits (164), Expect = 7e-11
Identities = 33/74 (44%), Positives = 46/74 (62%)
Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279
+K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 280 HQDALQKFKQAKKG 293
++ + + K+G
Sbjct: 446 QEELVAMLRSTKQG 459
Score = 46.2 bits (108), Expect = 2e-04
Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%)
Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236
DA A L+Q + PR + + +P P + S A +
Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385
Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296
L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T
Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445
Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319
+ E ++++ G ++VI R+
Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469
Score = 45.1 bits (105), Expect = 5e-04
Identities = 19/66 (28%), Positives = 36/66 (54%)
Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198
I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V +
Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469
Query: 1199 TPEAMP 1204
+P
Sbjct: 470 EGHFLP 475
Score = 43.9 bits (102), Expect = 0.001
Identities = 65/286 (22%), Positives = 109/286 (38%), Gaps = 48/286 (16%)
Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255
+ T L P S ++ V + G+ LG +V S+ G I G++++ I +
Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242
Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311
+G E + I+++N + T A F+QA K L L + R S+
Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302
Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348
L+ PP+ +L+ + D+S+ + SP P KP
Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362
Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391
+ + +++ L+K G+G V I G IFV + P
Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419
Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437
A DGRL+ GD I+E++ V T E+ +L G +V
Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465
Score = 31.6 bits (70), Expect = 5.3
Identities = 10/33 (30%), Positives = 26/33 (78%)
Query: 1153 EGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185
+G ++ ++++++NG+SL G ++H+A+ LR++
Sbjct: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511
>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
Length = 728
Score = 65.9 bits (159), Expect = 3e-10
Identities = 58/218 (26%), Positives = 104/218 (47%), Gaps = 18/218 (8%)
Query: 1113 VTILHKEEGAGLGFSLAGGA-----DLENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167
V + K+ G LG ++AGGA DL VI+V P G+ S++G I+ G+ +L+++G
Sbjct: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE---PGGVISRDGRIKTGDILLNVDG 563
Query: 1168 KSLKGTTHHDALAILRQAREPRQA-VIVTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226
L + +A+A+L++ + ++ P+ ++ DS + + SD S
Sbjct: 564 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSW 623
Query: 1227 TA--EATVCT-----VTLEKMSAG-LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETV 1278
E C + L + +AG LGF + GG +G+KP I I +G + +
Sbjct: 624 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683
Query: 1279 QPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316
+ GD +L + G + G+ ++K L G +T+ I
Sbjct: 684 RCGDILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 720
Score = 60.8 bits (146), Expect = 8e-09
Identities = 49/196 (25%), Positives = 91/196 (46%), Gaps = 17/196 (8%)
Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGL 278
+ K + LG ++ GG + IYV ++ GG + DGR++ GD +L ++G + +
Sbjct: 510 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 569
Query: 279 THQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALES 338
+ +A+ K+ ++ + + P CS SP +L S+ + S S
Sbjct: 570 SRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS--SP---AALDSNHNMAPPSD----WS 620
Query: 339 PSAPISTAKPN--YRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVA 393
PS + P Y V + AG +G C V ++ +G F+ ++ G+ A
Sbjct: 621 PSWVMWLELPRCLYNCKDIVLRRNTAG---SLGFCIVGGYEEYNGNKPFFIKSIVEGTPA 677
Query: 394 HLDGRLRCGDEIVEIS 409
+ DGR+RCGD ++ ++
Sbjct: 678 YNDGRIRCGDILLAVN 693
Score = 58.9 bits (141), Expect = 3e-08
Identities = 33/84 (39%), Positives = 49/84 (58%), Gaps = 1/84 (1%)
Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275
+IVL + A LGF IVGG + G ++K+I G A DGR++ GD +L +NG S
Sbjct: 638 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697
Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299
+G+ H L + + KG +TLT+
Sbjct: 698 SGMIHA-CLARLLKELKGRITLTI 720
Score = 55.1 bits (131), Expect = 4e-07
Identities = 49/225 (21%), Positives = 95/225 (42%), Gaps = 11/225 (4%)
Query: 1109 DGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168
D HV + LG L D + + V G+A + G +++ + VL+ING
Sbjct: 378 DSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDRVLAINGH 435
Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKL---TPEAMPDLNSSTDSAASASAASDVSVE 1225
L+ + A A L QA E R ++V+R++ +P+ + +++ + S +
Sbjct: 436 DLRYGSPESA-AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP 494
Query: 1226 STAEATVC----TVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQP 1280
T+ V ++K LG ++ GG D P+ + + G + ++
Sbjct: 495 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKT 554
Query: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325
GD +L + G + ++R EA ++K V + K + +E
Sbjct: 555 GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599
Score = 45.1 bits (105), Expect = 5e-04
Identities = 37/188 (19%), Positives = 80/188 (42%), Gaps = 19/188 (10%)
Query: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302
G+++ + GG A G+L+E D +L +NG + + + A + +++ + + R
Sbjct: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQV 464
Query: 303 LTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMV----EVSL 358
P + +S+ P +T KP + + V++
Sbjct: 465 RQRSPDIFQEAG--------------WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNI 510
Query: 359 QKEAGVGLGIGLC-SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417
QK+ G LG+ + + + I+V ++ PG V DGR++ GD ++ + + ++
Sbjct: 511 QKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVS 570
Query: 418 LNEVYTIL 425
+E +L
Sbjct: 571 RSEAVALL 578
Score = 40.8 bits (94), Expect = 0.009
Identities = 25/76 (32%), Positives = 44/76 (57%), Gaps = 3/76 (3%)
Query: 224 AKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283
++ L +VGG ++ + I ++ I+ G A DGRL GD IL++NG ++ + H A
Sbjct: 283 SESLSIRLVGGSETPL--VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340
Query: 284 LQKFKQAKKGLLTLTV 299
++ +Q + +L LTV
Sbjct: 341 VRLLRQPCQ-VLWLTV 355
Score = 39.3 bits (90), Expect = 0.025
Identities = 17/72 (23%), Positives = 37/72 (51%)
Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172
+ I + L L GG++ I + ++ +G+ +++G + G+ +L +NG +
Sbjct: 275 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334
Query: 1173 TTHHDALAILRQ 1184
H+ A+ +LRQ
Sbjct: 335 VPHNYAVRLLRQ 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,596,013
Number of Sequences: 37866
Number of extensions: 3117173
Number of successful extensions: 16242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 602
Number of HSP's that attempted gapping in prelim test: 13027
Number of HSP's gapped (non-prelim): 3424
length of query: 1332
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1218
effective length of database: 13,930,794
effective search space: 16967707092
effective search space used: 16967707092
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.