BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|148833504 interleukin 16 isoform 2 [Homo sapiens] (1332 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|148833504 interleukin 16 isoform 2 [Homo sapiens] 2630 0.0 gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] 1236 0.0 gi|87196343 PDZ domain containing 2 [Homo sapiens] 229 1e-59 gi|148746189 multiple PDZ domain protein [Homo sapiens] 95 5e-19 gi|112382257 InaD-like [Homo sapiens] 83 2e-15 gi|119120907 par-3 partitioning defective 3 homolog B isoform a ... 82 3e-15 gi|119120903 par-3 partitioning defective 3 homolog B isoform c ... 82 3e-15 gi|45827729 scribble isoform b [Homo sapiens] 81 8e-15 gi|45827731 scribble isoform a [Homo sapiens] 81 8e-15 gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 80 1e-14 gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 80 1e-14 gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 78 5e-14 gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] 77 8e-14 gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 77 1e-13 gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 77 1e-13 gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 76 2e-13 gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 75 3e-13 gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 75 5e-13 gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 75 5e-13 gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 74 9e-13 gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 74 9e-13 gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 74 9e-13 gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 74 9e-13 gi|157388993 synaptojanin 2 binding protein [Homo sapiens] 74 1e-12 gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 72 3e-12 gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 71 6e-12 gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 70 1e-11 gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 70 1e-11 gi|119120897 par-3 partitioning defective 3 homolog B isoform b ... 68 7e-11 gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] 66 3e-10 >gi|148833504 interleukin 16 isoform 2 [Homo sapiens] Length = 1332 Score = 2630 bits (6817), Expect = 0.0 Identities = 1332/1332 (100%), Positives = 1332/1332 (100%) Query: 1 MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS 60 MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS Sbjct: 1 MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSS 60 Query: 61 VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA 120 VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA Sbjct: 61 VQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEA 120 Query: 121 QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL 180 QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL Sbjct: 121 QSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQL 180 Query: 181 DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 240 DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG Sbjct: 181 DCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYG 240 Query: 241 PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR 300 PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR Sbjct: 241 PIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVR 300 Query: 301 TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK 360 TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK Sbjct: 301 TRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQK 360 Query: 361 EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE 420 EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE Sbjct: 361 EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE 420 Query: 421 VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES 480 VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES Sbjct: 421 VYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLES 480 Query: 481 SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS 540 SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS Sbjct: 481 SWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDIS 540 Query: 541 THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP 600 THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP Sbjct: 541 THSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPP 600 Query: 601 PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC 660 PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC Sbjct: 601 PRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGC 660 Query: 661 PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC 720 PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC Sbjct: 661 PGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDC 720 Query: 721 IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK 780 IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK Sbjct: 721 IKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVK 780 Query: 781 KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR 840 KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR Sbjct: 781 KGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIR 840 Query: 841 QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP 900 QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP Sbjct: 841 QRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQP 900 Query: 901 EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP 960 EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP Sbjct: 901 EQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMP 960 Query: 961 SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE 1020 SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE Sbjct: 961 SQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKE 1020 Query: 1021 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS 1080 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS Sbjct: 1021 GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQS 1080 Query: 1081 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT 1140 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT Sbjct: 1081 VISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVIT 1140 Query: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP Sbjct: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200 Query: 1201 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP 1260 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP Sbjct: 1201 EAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKP 1260 Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS 1320 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS Sbjct: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKS 1320 Query: 1321 LQSKETTAAGDS 1332 LQSKETTAAGDS Sbjct: 1321 LQSKETTAAGDS 1332 >gi|27262655 interleukin 16 isoform 1 precursor [Homo sapiens] Length = 631 Score = 1236 bits (3197), Expect = 0.0 Identities = 631/631 (100%), Positives = 631/631 (100%) Query: 702 MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 761 MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL Sbjct: 1 MDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKL 60 Query: 762 DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 821 DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA Sbjct: 61 DTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPA 120 Query: 822 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 881 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG Sbjct: 121 SREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEG 180 Query: 882 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 941 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL Sbjct: 181 RFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPL 240 Query: 942 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 1001 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS Sbjct: 241 LRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKS 300 Query: 1002 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 1061 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL Sbjct: 301 LLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGL 360 Query: 1062 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 1121 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG Sbjct: 361 TEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEG 420 Query: 1122 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 1181 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI Sbjct: 421 AGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAI 480 Query: 1182 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 1241 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS Sbjct: 481 LRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMS 540 Query: 1242 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW Sbjct: 541 AGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 600 Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS Sbjct: 601 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 631 Score = 84.3 bits (207), Expect = 7e-16 Identities = 64/225 (28%), Positives = 113/225 (50%), Gaps = 24/225 (10%) Query: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277 +L K + GLGFS+ GG D I ++ +F G A+ +G +Q+G+E+L +NG+S+ G Sbjct: 414 ILHKEEGAGLGFSLAGGADLENKVITVH--RVFPNGLASQEGTIQKGNEVLSINGKSLKG 471 Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337 TH DAL +QA++ + V +LT P L+SST S A Sbjct: 472 TTHHDALAILRQAREPRQAVIVTRKLT----------PEAMPDLNSST------DSAASA 515 Query: 338 SPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAH 394 S ++ +S + V+L+K AG+G + G S+ + ++ ++ + G+ + Sbjct: 516 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLT---INRIFKGAASE 572 Query: 395 LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439 ++ GDEI+++ + + LT E + I+ GPV I++ R Sbjct: 573 QSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 617 Score = 64.3 bits (155), Expect = 7e-10 Identities = 38/107 (35%), Positives = 58/107 (54%), Gaps = 2/107 (1%) Query: 196 SLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAA 255 S S A V +A+V + V ++ + GLGFS+ GGK S++G + + IF G A+ Sbjct: 514 SASAASDVSVESTAEATVCT--VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 571 Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302 +Q GDEIL+L G +M GLT +A K G +T+ +R + Sbjct: 572 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 618 Score = 35.8 bits (81), Expect = 0.28 Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 1/87 (1%) Query: 358 LQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417 L KE G GLG L + I VH + P +A +G ++ G+E++ I+ + T Sbjct: 415 LHKEEGAGLGFSLAGGADLEN-KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 473 Query: 418 LNEVYTILSHCDPGPVPIIVSRHPDPQ 444 ++ IL +IV+R P+ Sbjct: 474 HHDALAILRQAREPRQAVIVTRKLTPE 500 >gi|87196343 PDZ domain containing 2 [Homo sapiens] Length = 2839 Score = 229 bits (585), Expect = 1e-59 Identities = 154/395 (38%), Positives = 216/395 (54%), Gaps = 23/395 (5%) Query: 173 RKSLSQQLDCPAGKAAG--TSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFS 230 + SL Q LD + + TRSLST Q+ P ++ SVIS I L K + KGLGFS Sbjct: 541 KHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFS 600 Query: 231 IVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290 I GG+D I G +GI+VKTIF G+AA DGRL+EGDEIL++NG + GLT Q+A+ FKQ Sbjct: 601 IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660 Query: 291 KKGLLTLTVRTRLTAPP----SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + GL LTVRT+L +P S +H+S + ++S + S S S T Sbjct: 661 RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEG-SSSSLGRKTP 719 Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIV 406 P RI++EV+L KE VGLGIG C + GI++H+L+PGSVA ++ L GD+I+ Sbjct: 720 GPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQIL 779 Query: 407 EISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKE 466 E++ V L++V+ ILS C PGPV +++ RHP+P+VSEQ++ E +A++ KE Sbjct: 780 EVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQE--SKE 837 Query: 467 RHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPH---RRAQKVMIRSSSDSSYMSGSPGG 523 + G S + +L E E + H M+ S D + Sbjct: 838 ANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDH------- 890 Query: 524 SPGSG--SAEKPSSDVDISTH-SPSLPLAREPVVL 555 PGSG ++E+ S STH P P A V L Sbjct: 891 -PGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTL 924 Score = 208 bits (530), Expect = 2e-53 Identities = 177/526 (33%), Positives = 264/526 (50%), Gaps = 60/526 (11%) Query: 833 SSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKP-LGKHEEGRF-SGLLGR- 889 S+S S++QRI SFE ++ D+ + P ++KP +G+ G SG LG Sbjct: 2329 STSFFSVKQRIKSFENLANA---DRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSLGHP 2385 Query: 890 -GAAPTLVPQQPEQVLSSGSPAASEARD--PGVSESPPP-----GRQPNQKTLPPGPDPL 941 AA L+ + LSS S SEA P +++SP RQ +T G D Sbjct: 2386 GDAAARLLRRS----LSSCSENQSEAGTLLPQMAKSPSIMTLTISRQNPPETSSKGSDSE 2441 Query: 942 LRL------LSTQAEESQGPVLKMPS--QRARSFPLTRSQSCETKLL-----DEKTSKLY 988 L+ + T PV + S + + P++RS+ E + L D+ S+ Y Sbjct: 2442 LKKSLGPLGIPTPTMTLASPVKRNKSSVRHTQPSPVSRSKLQELRALSMPDLDKLCSEDY 2501 Query: 989 SISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGS------AET-- 1040 S S+ + K+ L I+ ++P P G S + GS AET Sbjct: 2502 SAGP--SAVLFKTEL----EITPRRSPGPPAGGVSCPEKGGNRACPGGSGPKTSAAETPS 2555 Query: 1041 SALDTGFSL-NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099 SA DTG + +L R ++ L + GD LQS S + S + LI+E K Sbjct: 2556 SASDTGEAAQDLPFRRSWSVNLDQLLVSA-GDQQRLQSVLSSVG--SKSTILTLIQEAKA 2612 Query: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKG 1159 E + + +L+++EG+GLGFS+AGG D+E K ITVHRVF G ASQEGT+ +G Sbjct: 2613 QSENE----EDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRG 2668 Query: 1160 NEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAA 1219 + +LS+NG SL G H + L +L QA+ + A++V +K + P +A Sbjct: 2669 DFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLL 2728 Query: 1220 SDVSV-------ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAAS 1272 S ++ S A V + K SAGLG SL+GGK S+ GD PL I R++KG A+ Sbjct: 2729 SRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAA 2788 Query: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 EQ+ ++ GDEIL + G + GL F+AWNI+K++P+GPV ++IR+ Sbjct: 2789 EQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRK 2834 Score = 90.5 bits (223), Expect = 1e-17 Identities = 69/232 (29%), Positives = 112/232 (48%), Gaps = 27/232 (11%) Query: 1111 IHVTILHKEEGAGLGFSLAGGADL--ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 I + L+KE+G GLGFS+AGG D I V +FPNG A+++G +++G+E+L +NG Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643 Query: 1169 SLKGTTHHDALAILRQARE-----PRQAVIVTRKLTPEAMP-------DLNSSTDSAASA 1216 +KG T +A+ +Q R + +V+ LTP + P N +T ASA Sbjct: 644 PIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASA 703 Query: 1217 SAASDVSVESTAEAT-------VCTVTLEK---MSAGLGFSLEGGKGSLHGDKPLTINRI 1266 + + S S T V VTL K + G+G + S G + I+ + Sbjct: 704 GGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPG---IYIHSL 760 Query: 1267 FKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 G+ ++ + GD+IL++ ++ + I+ P GPV +VI R Sbjct: 761 APGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812 Score = 79.7 bits (195), Expect = 2e-14 Identities = 69/228 (30%), Positives = 106/228 (46%), Gaps = 19/228 (8%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 IVL + + GLGFS+ GG D P I V +F+ GAA+ +G + GD +L +NG S+A Sbjct: 2623 IVLNRKEGSGLGFSVAGGTD--VEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLA 2680 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLC--RSLSSSTCITKDSSSF 334 GL H + L+ QA+ L V + P + PP + L S I + Sbjct: 2681 GLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLE---- 2736 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSV 392 P S A + + VEV L+ AG+GL + G SV + + + G Sbjct: 2737 ----PGIGRSVAVHD-ALCVEV-LKTSAGLGLSLDGGKSSV---TGDGPLVIKRVYKGGA 2787 Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRH 440 A G + GDEI+ I+ P+ L + + I+ GPV +++ +H Sbjct: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLIRKH 2835 Score = 62.4 bits (150), Expect = 3e-09 Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 5/112 (4%) Query: 223 QAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQD 282 ++ GLG + GG+ S P I V + GGAA DGRL GDE+L +NG + GL+H++ Sbjct: 340 ESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399 Query: 283 ALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 A+ + A G++ L V ++ + L S +SL T +D SS+ Sbjct: 400 AVAILRSA-TGMVQLVVASKENSAEDLLRLTS----KSLPDLTSSVEDVSSW 446 Score = 60.8 bits (146), Expect = 8e-09 Identities = 37/107 (34%), Positives = 59/107 (55%), Gaps = 10/107 (9%) Query: 1119 EEGAGLGFSLAGGADLENK--VITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176 +E GLG ++GG + I V +V G A ++G + G+E+L ING L G +H Sbjct: 339 KESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHE 398 Query: 1177 DALAILRQAREPRQAVIVTR--------KLTPEAMPDLNSSTDSAAS 1215 +A+AILR A Q V+ ++ +LT +++PDL SS + +S Sbjct: 399 EAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS 445 Score = 52.4 bits (124), Expect = 3e-06 Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 6/165 (3%) Query: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAA 1214 ++++ NE++ NG L + R R+ ++ + + ST S + Sbjct: 514 SVEEYNELMVRNGDP-----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLS 568 Query: 1215 SASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQ 1274 + S + + ++ + EK GLGFS+ GG+ + G + + IF ++ + Sbjct: 569 TTQVESPWRLIRPSVISIIGLYKEK-GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAE 627 Query: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319 ++ GDEIL + G ++GLT EA + K + G + +R K Sbjct: 628 DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTK 672 Score = 46.6 bits (109), Expect = 2e-04 Identities = 26/89 (29%), Positives = 48/89 (53%), Gaps = 1/89 (1%) Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296 L K S GLG + GG+GS + + ++ +G A+ + + GDE+L + G + GL+ Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396 Query: 1297 RFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325 EA I+++ G V +V+ K +++ Sbjct: 397 HEEAVAILRS-ATGMVQLVVASKENSAED 424 Score = 30.8 bits (68), Expect = 9.1 Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 1/57 (1%) Query: 382 IFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVS 438 I V + G AH DGRL GDE++ I+ + L+ E IL G V ++V+ Sbjct: 361 IVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSA-TGMVQLVVA 416 Score = 30.8 bits (68), Expect = 9.1 Identities = 72/331 (21%), Positives = 109/331 (32%), Gaps = 48/331 (14%) Query: 493 EKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREP 552 E S P R K RS + GSP SPG +A P S S P Sbjct: 1263 ENPSQPASPRVTKCKARSPVRLPH-EGSP--SPGEKAAAPPDYSKTRSASETSTPHNTRR 1319 Query: 553 VV-----------LSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSK-PKPP 600 V ++ A + LP + E R P K + P SS+ P Sbjct: 1320 VAALRGAGPGAEGMTPAGAVLPGDPLTSQEQRQGAPGNHSKALEMTGIHAPESSQEPSLL 1379 Query: 601 PRKYFKSDSDPQKSLE-----ERENSSCS--SGHTPPTCGQEA--RELLPLLLPQEDTAG 651 S PQ SL + +C SGH P +E+ ++ + + +A Sbjct: 1380 EGADSVSSRAPQASLSMLPSTDNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDASAA 1439 Query: 652 RSPSASAGCPGP-----------GIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQA 700 RSPS+ G G G G + E PG + +SP + P + A Sbjct: 1440 RSPSSQTGDSGSQEGSAQGHPPAGAGGGSSCRAEPVPGGQTSSP-RRAWAAGAPAYPQWA 1498 Query: 701 RMDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPK 760 D+ D ++ + +S S H + G D T P Sbjct: 1499 SQPSVLDSINPDKHFTVNKNFLSNYSRNFSSFH-----------EDSTSLSGLGDSTEPS 1547 Query: 761 LDTANGTPKVYKSADSSTVKKGPPVAPKPAW 791 L + G + S+D ++ + P + + W Sbjct: 1548 LSSMYGDAE-DSSSDPESLTEAPRASARDGW 1577 >gi|148746189 multiple PDZ domain protein [Homo sapiens] Length = 2041 Score = 94.7 bits (234), Expect = 5e-19 Identities = 65/219 (29%), Positives = 113/219 (51%), Gaps = 7/219 (3%) Query: 1103 ATLKQLDGIHVTILHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGN 1160 A ++ G+ + K LG S+AGG + L + I + + P G+A+Q ++ G+ Sbjct: 1823 ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGD 1882 Query: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 1220 +++I G S +G TH A+ +L+ A + +V S+ S + + Sbjct: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLT 1942 Query: 1221 DVSV--ESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-KGAASEQSET 1277 S+ + ++TLE+ GLGFS+ GG GS HGD P+ + +F KGAASE Sbjct: 1943 SSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGR- 2001 Query: 1278 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316 ++ GD+I+ + G +++G+T EA I+K G VT+++ Sbjct: 2002 LKRGDQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039 Score = 92.8 bits (229), Expect = 2e-18 Identities = 69/211 (32%), Positives = 113/211 (53%), Gaps = 26/211 (12%) Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM-AG 277 L+K + GLGFS+VG + G +GI+V+ I G A DGRL+E D+IL +NG+++ Sbjct: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199 Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALE 337 +THQ A+ ++AK + + R L P L +SP + RS S+++ I+ S+ Sbjct: 200 ITHQQAISILQKAKDTVQLVIARGSL---PQL---VSPIVSRSPSAASTISAHSN----- 248 Query: 338 SPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDG 397 P+ +++ M + L + G GLG G+ +G+ V T+ PG VA G Sbjct: 249 ----PV-----HWQHMETIELVND-GSGLGFGIIGGK----ATGVIVKTILPGGVADQHG 294 Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428 RL GD I++I D+ + ++ +V +L C Sbjct: 295 RLCSGDHILKIGDTDLAGMSSEQVAQVLRQC 325 Score = 83.6 bits (205), Expect = 1e-15 Identities = 44/84 (52%), Positives = 62/84 (73%), Gaps = 2/84 (2%) Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 +I L +G GLGFSIVGG S +G + IYVKT+FA GAA+ DGRL+ GD+I+ +NG+S+ Sbjct: 1958 SITLERGP-DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSL 2016 Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299 G+TH++A+ K+ KG +TL V Sbjct: 2017 EGVTHEEAVAILKRT-KGTVTLMV 2039 Score = 81.6 bits (200), Expect = 4e-15 Identities = 74/258 (28%), Positives = 113/258 (43%), Gaps = 51/258 (19%) Query: 173 RKSLSQQLDCP-AGKAAGTSRPTRSLSTAQLVQPSGGLQASVI----SNIVLMKGQAKGL 227 +K+ SQ L P +G S S S+ + S +I + I + KG+ GL Sbjct: 1581 KKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRT-GL 1639 Query: 228 GFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKF 287 G SIVGG D++ G I I+ ++ GAA DGRL GD+ILE+NG + TH +A+ Sbjct: 1640 GLSIVGGSDTLLGAIIIH--EVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697 Query: 288 KQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAK 347 +Q + R RLT + +C +L+ Sbjct: 1698 RQTPQ-------RVRLTLYRDEAPYKEEEVCDTLT------------------------- 1725 Query: 348 PNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVE 407 + LQK+ G GLG+ S+ + +G+FV + G +A DGRL GD+I+ Sbjct: 1726 --------IELQKKPGKGLGL---SIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILM 1774 Query: 408 ISDSPVHCLTLNEVYTIL 425 ++ V T V +L Sbjct: 1775 VNGEDVRNATQEAVAALL 1792 Score = 79.3 bits (194), Expect = 2e-14 Identities = 62/226 (27%), Positives = 98/226 (43%), Gaps = 15/226 (6%) Query: 1114 TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 TI +G+GLGF + GG + + V + P G+A Q G + G+ +L I L G Sbjct: 257 TIELVNDGSGLGFGIIGG---KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGM 313 Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS---DVSVESTAEA 1230 + +LRQ + +I + P T S++ S D S + E+ Sbjct: 314 SSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEES 373 Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIF-----KGAASEQSETVQPGDEIL 1285 V L K GLG ++ G GDK L + IF K +A E +Q GD+I+ Sbjct: 374 ETFDVELTKNVQGLGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429 Query: 1286 QLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331 + GT +QG T +A +++ + ++RR Q E + D Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSRED 475 Score = 78.2 bits (191), Expect = 5e-14 Identities = 65/230 (28%), Positives = 113/230 (49%), Gaps = 14/230 (6%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I L KG + GLG S+ G KD + +++ I GAA DGRLQ DE+LE+NG+ + Sbjct: 1351 IELEKGHS-GLGLSLAGNKDR--SRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILY 1407 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTR-LTAPPSLC-SHLSPPLCRSLSSSTCITKDSSSF 334 G +HQ+A K A + + +R + ++C + PL S+S + + Sbjct: 1408 GRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPL---PSNSENLQNKETEP 1464 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAH 394 + + A + + +++ + + L K+ G GLGI + +SG+ + +L+ VA Sbjct: 1465 TVTTSDAAVDLS--SFKNVQHLELPKDQG-GLGIAISEE---DTLSGVIIKSLTEHGVAA 1518 Query: 395 LDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 444 DGRL+ GD+I+ + D V + + ++L I + +PD Q Sbjct: 1519 TDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQ 1568 Score = 75.9 bits (185), Expect = 2e-13 Identities = 69/277 (24%), Positives = 125/277 (45%), Gaps = 33/277 (11%) Query: 1030 EDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEE 1089 E+ AA A D +N +LR+ T D+ + Q+ Q V L +E Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATH--------DEAINVLRQTPQRVRLTLYRDE 1712 Query: 1090 LKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGL 1149 +E +V D T++ L K+ G GLG S+ G + + + V + G+ Sbjct: 1713 AP--YKEEEVCDTLTIE---------LQKKPGKGLGLSIVGKRN--DTGVFVSDIVKGGI 1759 Query: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209 A +G + +G+++L +NG+ ++ T A+L+ + L+ P SS Sbjct: 1760 ADADGRLMQGDQILMVNGEDVRNATQEAVAALLK---------VSEGSLSSFTFPLSGSS 1810 Query: 1210 TDSAASASAASDVSVESTAEATVCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268 T + +S+ + TV ++K + LG S+ GG GS GD P+ I + Sbjct: 1811 TSESLESSSKKNALASEIQGLR--TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHP 1868 Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + Q++ ++ GD I+ + GT+ +G+T +A N++K Sbjct: 1869 TGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905 Score = 72.4 bits (176), Expect = 3e-12 Identities = 57/201 (28%), Positives = 91/201 (45%), Gaps = 35/201 (17%) Query: 1101 DEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGN 1160 D AT + G TI + GLG S+ GG+D I +H V+ G A ++G + G+ Sbjct: 1616 DPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGD 1675 Query: 1161 EVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAAS 1220 ++L +NG L+ TH +A+ +LRQ TP+ + L D A Sbjct: 1676 QILEVNGIDLRKATHDEAINVLRQ--------------TPQRV-RLTLYRDEA------- 1713 Query: 1221 DVSVESTAEATVC-TVTLE---KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276 E VC T+T+E K GLG S+ G + D + ++ I KG ++ Sbjct: 1714 -----PYKEEEVCDTLTIELQKKPGKGLGLSIVGKR----NDTGVFVSDIVKGGIADADG 1764 Query: 1277 TVQPGDEILQLGGTAMQGLTR 1297 + GD+IL + G ++ T+ Sbjct: 1765 RLMQGDQILMVNGEDVRNATQ 1785 Score = 72.4 bits (176), Expect = 3e-12 Identities = 69/239 (28%), Positives = 100/239 (41%), Gaps = 39/239 (16%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I L K KGLG SIVG ++ G++V I GG A ADGRL +GD+IL +NGE + Sbjct: 1726 IELQKKPGKGLGLSIVGKRNDT----GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336 T Q+A+ + +G L S + PL S S+S + S AL Sbjct: 1782 NAT-QEAVAALLKVSEGSL---------------SSFTFPLSGS-STSESLESSSKKNAL 1824 Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396 S + T + + + GVG +G VP IF+ + P VA Sbjct: 1825 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLG--DVP-------IFIAMMHPTGVAAQT 1875 Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCD---------PGPVPIIVSRHPDPQVS 446 +LR GD IV I + +T + +L + G V ++ +P S Sbjct: 1876 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASS 1934 Score = 64.3 bits (155), Expect = 7e-10 Identities = 69/275 (25%), Positives = 114/275 (41%), Gaps = 26/275 (9%) Query: 171 SNRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASV-----ISNIVLMKGQAK 225 + +++++ L G + + P ST++ ++ S A + + + KG Sbjct: 1783 ATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTD 1842 Query: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285 LG SI GG S G + I++ + G AA +L+ GD I+ + G S G+TH A+ Sbjct: 1843 SLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVN 1902 Query: 286 KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIST 345 K A + V + + H P SLS T +SS + P Sbjct: 1903 LLKNASGSIEMQVVAGGDVSV--VTGHQQEPASSSLS----FTGLTSSSIFQDDLGP--- 1953 Query: 346 AKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVAHLDGRLRCG 402 P + S+ E G G+G V + G I+V T+ A DGRL+ G Sbjct: 1954 --PQCK-----SITLERGPD-GLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRG 2005 Query: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437 D+I+ ++ + +T E IL G V ++V Sbjct: 2006 DQIIAVNGQSLEGVTHEEAVAILKR-TKGTVTLMV 2039 Score = 62.4 bits (150), Expect = 3e-09 Identities = 90/407 (22%), Positives = 160/407 (39%), Gaps = 47/407 (11%) Query: 55 GIFHSSVQLADTSEA-GPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSRE 113 GIF S+ + E G + D +A + LQ N + R T R Sbjct: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463 Query: 114 KPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSA--APTDRQPYSLCS 171 + E S + A + N++ + ++ DF + ++ PT+ + Y L S Sbjct: 464 MKQEAELMSREDVTKDA--DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLS 521 Query: 172 NRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSI 231 + + D +AA ++ R + G+ ++ V + GLG S+ Sbjct: 522 --AEIEEIEDAQKQEAALLTKWQRIM----------GINYEIVVAHVSKFSENSGLGISL 569 Query: 232 VGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAK 291 ++ G +++++ G G+L GDE+LE+NG ++ G HQD + K+ Sbjct: 570 ----EATVGHH--FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623 Query: 292 KGLLTLTVRTRLTAPPSLCSHL-SPPLC-----------------RSLSSSTCITKDSSS 333 + V R T PP+ S L S LC S + + + Sbjct: 624 --IEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAG 681 Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEA-GVGLGIGLCSVPYFQCISGIFVHTLSPGSV 392 + E AP++ + + + L+K + G+G I P + I + +L PG + Sbjct: 682 QSTEEVQAPLAMWEAGIQ---HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGI 738 Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439 A DGRL GD ++ ++D + +L E L G V I V++ Sbjct: 739 AEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785 Score = 62.4 bits (150), Expect = 3e-09 Identities = 72/299 (24%), Positives = 119/299 (39%), Gaps = 49/299 (16%) Query: 1065 KEDDDGDHSSLQSGQSVISLLSSEE----LKKLIEEVKVLD--EATL----KQLDGIH-- 1112 KE+ + D L S ++ L + EE L IEE++ EA L +++ GI+ Sbjct: 491 KENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYE 550 Query: 1113 VTILHKE---EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 1169 + + H E +GLG SL + V P G G + G+E+L +NG + Sbjct: 551 IVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606 Query: 1170 LKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL----------------------- 1206 L G H D + IL++ V R + P +L Sbjct: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666 Query: 1207 NSSTDSAASASAASDVSVESTA------EATVCTVTLEKMSAGLGFSLEGGKGSLH-GDK 1259 +S T+ A + S E EA + + LEK S GLGFS+ + + Sbjct: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAST 726 Query: 1260 PLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 + I + G +E+ + PGD ++ + ++ + EA +K P G V I + + Sbjct: 727 VIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785 Score = 58.9 bits (141), Expect = 3e-08 Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 68/314 (21%) Query: 217 IVLMKGQAKGLGFSIVGGKDS----IYGPI--GIYVKTIFAGGAAAADGRLQEGDEILEL 270 + L + +K LG SIVGG+ G + GI++K + A +G L+ GD I+E+ Sbjct: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211 Query: 271 NGESMAGLTHQDALQKFKQAKKGLL----TLTVRTRLTAPPSLCSHLSP--------PLC 318 +G + +H+ A++ ++A ++ ++ R R + PSL +L P P Sbjct: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFA 1271 Query: 319 RSLSSSTCITKDSSSFALESPSAPISTAKP-----------------NYRIMVEVSLQKE 361 SL + K S E AP+ + P +I +V + E Sbjct: 1272 DSLQINA--DKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE 1329 Query: 362 AGV--------------------------GLGIGLCSVPYFQCISGIFVHTLSPGSVAHL 395 G GLG+ L +S +F+ + P A Sbjct: 1330 FGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMS-VFIVGIDPNGAAGK 1388 Query: 396 DGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVA 455 DGRL+ DE++EI+ ++ + +I+ C P V II R+ D + Q+ Sbjct: 1389 DGRLQIADELLEINGQILYGRSHQNASSIIK-CAPSKVKIIFIRNKD---AVNQMAVCPG 1444 Query: 456 QAVENTKFGKERHQ 469 AVE E Q Sbjct: 1445 NAVEPLPSNSENLQ 1458 Score = 58.9 bits (141), Expect = 3e-08 Identities = 49/197 (24%), Positives = 93/197 (47%), Gaps = 18/197 (9%) Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170 +H+ L K +GLG SLAG D + + + PNG A ++G +Q +E+L ING+ L Sbjct: 1348 LHMIELEKGH-SGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406 Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRK--------LTPEAMPDLNSSTDSAASAS----- 1217 G +H +A +I++ A + + + K A+ L S++++ + Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466 Query: 1218 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 1277 SD +V+ ++ V + L K GLG ++ + +L G + I + + + Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSG---VIIKSLTEHGVAATDGR 1522 Query: 1278 VQPGDEILQLGGTAMQG 1294 ++ GD+IL + + G Sbjct: 1523 LKVGDQILAVDDEIVVG 1539 Score = 58.5 bits (140), Expect = 4e-08 Identities = 64/266 (24%), Positives = 111/266 (41%), Gaps = 47/266 (17%) Query: 225 KGLGFSIVGG-KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283 +GLG +I G D P GI+VK+I A DGR+Q GD+I+ ++G ++ G T+Q A Sbjct: 385 QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQA 444 Query: 284 LQKFKQAKKGLLTLTVRTRLTAPPSLCSH--------LSPPLCRSLSSS-------TCIT 328 ++ + + +L +R + L S LSP + + T Sbjct: 445 VEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSST 504 Query: 329 KDSSSFALESPSAPISTAK-----------------------PNYRIMVEVSLQKEAGVG 365 ++++ E P+ +A+ NY I+V + G Sbjct: 505 RNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSG 564 Query: 366 LGIGLCSVPYFQCISGIFVHTLSP-GSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTI 424 LGI L + + F+ ++ P G V H G+L GDE++E++ + +V I Sbjct: 565 LGISLEAT-----VGHHFIRSVLPEGPVGH-SGKLFSGDELLEVNGITLLGENHQDVVNI 618 Query: 425 LSHCDPGPVPIIVSRHPDPQVSEQQL 450 L P V ++ R P ++ +L Sbjct: 619 LKEL-PIEVTMVCCRRTVPPTTQSEL 643 Score = 55.8 bits (133), Expect = 3e-07 Identities = 74/303 (24%), Positives = 123/303 (40%), Gaps = 41/303 (13%) Query: 172 NRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASV-------ISNIVLMKGQA 224 N+ +++Q CP + +L + A+V + ++ L K Q Sbjct: 1432 NKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG 1491 Query: 225 KGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDAL 284 GLG +I +D++ G I +K++ G AA DGRL+ GD+IL ++ E + G + + Sbjct: 1492 -GLGIAI-SEEDTLSGVI---IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFI 1546 Query: 285 QKFKQAKKGLLTLTVRTR---LTAPPSLCSHLSPPLCRSLSS---------------STC 326 K AK + LT+ A PS S S S +T Sbjct: 1547 SLLKTAKM-TVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605 Query: 327 ITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG-IFVH 385 + + FA + + PI P +E+S + G+GL V + G I +H Sbjct: 1606 RSSTPAIFASDPATCPII---PGCETTIEISKGRT-----GLGLSIVGGSDTLLGAIIIH 1657 Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445 + A DGRL GD+I+E++ + T +E +L P V + + R P Sbjct: 1658 EVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ-TPQRVRLTLYRDEAPYK 1716 Query: 446 SEQ 448 E+ Sbjct: 1717 EEE 1719 Score = 55.5 bits (132), Expect = 3e-07 Identities = 55/238 (23%), Positives = 112/238 (47%), Gaps = 34/238 (14%) Query: 1116 LHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175 L K++G GLG +++ L +I + +G+A+ +G ++ G+++L+++ + + G Sbjct: 1486 LPKDQG-GLGIAISEEDTLSGVIIK--SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542 Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDL---------NSST------------DSAA 1214 +++L+ A+ + I +A+P NSS +S Sbjct: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602 Query: 1215 SASAASDVSVESTAEATV-----CTVTLE--KMSAGLGFSLEGGKGSLHGDKPLTINRIF 1267 + S +S ++ ++ AT C T+E K GLG S+ GG +L G + I+ ++ Sbjct: 1603 NTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG--AIIIHEVY 1660 Query: 1268 KGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325 + A+ + + GD+IL++ G ++ T EA N+++ P V + + R KE Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ-RVRLTLYRDEAPYKE 1717 Score = 49.7 bits (117), Expect = 2e-05 Identities = 36/111 (32%), Positives = 59/111 (53%), Gaps = 3/111 (2%) Query: 198 STAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIY-GPIGIYVKTIFAGGAAA 256 ST ++ P +A I +I L KG +KGLGFSI+ +D I I ++++ GG A Sbjct: 683 STEEVQAPLAMWEAG-IQHIELEKG-SKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAE 740 Query: 257 ADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPP 307 DGRL GD ++ +N ++ + ++A++ K A G + + V L P Sbjct: 741 KDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791 Score = 48.5 bits (114), Expect = 4e-05 Identities = 61/245 (24%), Positives = 98/245 (40%), Gaps = 28/245 (11%) Query: 184 AGKAAGTSRPTRSLS-TAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI 242 AGK + SL+ A+ V + S I + KG + LG ++ KD + Sbjct: 975 AGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSS-LGMTVSANKDGL---- 1029 Query: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302 G+ V++I GGA + DGR+ GD IL +N ES +T+ A + + L+ ++ Sbjct: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR--RHSLIGPDIKIT 1087 Query: 303 LTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAP------------ISTAKPNY 350 P L + + SS + P P +TA N+ Sbjct: 1088 Y-VPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNW 1146 Query: 351 RIMVEVSLQKEAGVGLGIGLCS-------VPYFQCISGIFVHTLSPGSVAHLDGRLRCGD 403 V L +E LGI + + + + GIF+ + S A +G L+ GD Sbjct: 1147 NQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGD 1206 Query: 404 EIVEI 408 IVE+ Sbjct: 1207 RIVEV 1211 Score = 44.7 bits (104), Expect = 6e-04 Identities = 60/279 (21%), Positives = 102/279 (36%), Gaps = 71/279 (25%) Query: 1095 EEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEG 1154 EE + D K + G+ +TI G LE I V + + +G Sbjct: 371 EESETFDVELTKNVQGLGITIA----------GYIGDKKLEPSGIFVKSITKSSAVEHDG 420 Query: 1155 TIQKGNEVLSINGKSLKGTTHHDALAILRQARE-----------PRQAVIVTRK------ 1197 IQ G+++++++G +L+G T+ A+ +LR + ++A +++R+ Sbjct: 421 RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA 480 Query: 1198 -LTP----------EAMPDLNSSTDS--------------AASASAASDVSVESTA---- 1228 L+P E D SST + +A D + A Sbjct: 481 DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540 Query: 1229 ---------EATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQ 1279 E V V+ ++GLG SLE G I + S + Sbjct: 541 WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHF------IRSVLPEGPVGHSGKLF 594 Query: 1280 PGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 GDE+L++ G + G + NI+K LP + RR Sbjct: 595 SGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRR 633 Score = 43.1 bits (100), Expect = 0.002 Identities = 36/147 (24%), Positives = 60/147 (40%), Gaps = 16/147 (10%) Query: 1200 PEAMPDLNSSTDSAASASAASDVSVES--------------TAEATVCTVTLEKMSAGLG 1245 P A ++ S ++++ + DV E T + + LEK +GLG Sbjct: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361 Query: 1246 FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 SL G K + I I A+ + +Q DE+L++ G + G + A +IIK Sbjct: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419 Query: 1306 ALPDGPVTIVIRRKSLQSKETTAAGDS 1332 P I IR K ++ G++ Sbjct: 1420 CAPSKVKIIFIRNKDAVNQMAVCPGNA 1446 Score = 40.4 bits (93), Expect = 0.011 Identities = 27/86 (31%), Positives = 48/86 (55%), Gaps = 2/86 (2%) Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGL 1295 L+ S GLGFS+ G + G+ + + I +G+ + + ++ D+IL + G A+ Q + Sbjct: 141 LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200 Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSL 1321 T +A +I++ D V +VI R SL Sbjct: 201 THQQAISILQKAKD-TVQLVIARGSL 225 >gi|112382257 InaD-like [Homo sapiens] Length = 1801 Score = 83.2 bits (204), Expect = 2e-15 Identities = 68/238 (28%), Positives = 108/238 (45%), Gaps = 33/238 (13%) Query: 210 QASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILE 269 Q I I + + GLGFS+V + G + I+VK + G A D RL+E D+IL Sbjct: 128 QGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILA 187 Query: 270 LNGESM-AGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCIT 328 +N + ++HQ A+ +Q L + R + T Sbjct: 188 INHTPLDQNISHQQAIALLQQTTGSLRLIVAREPVH-----------------------T 224 Query: 329 KDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLS 388 K S+S +L + P + + + EV L + G GLG G+ SG+ V T+ Sbjct: 225 KSSTSSSLNDTTLPETVC---WGHVEEVELIND-GSGLGFGIVGGK----TSGVVVRTIV 276 Query: 389 PGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVS 446 PG +A DGRL+ GD I++I + V +T +V +L +C V ++V+R P +S Sbjct: 277 PGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCG-NSVRMLVARDPAGDIS 333 Score = 80.9 bits (198), Expect = 8e-15 Identities = 70/223 (31%), Positives = 106/223 (47%), Gaps = 47/223 (21%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I + KG++ GLG SIVGGKD+ I I+ ++ GAAA DGRL GD+ILE+NG + Sbjct: 1438 IEISKGRS-GLGLSIVGGKDTPLNAIVIH--EVYEEGAAARDGRLWAGDQILEVNGVDLR 1494 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336 +H++A+ +Q + + RL + +D + + Sbjct: 1495 NSSHEEAITALRQTPQ-------KVRLV----------------------VYRDEAHYRD 1525 Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396 E N I V LQK+AG GLG+ S+ + SG+F+ + G A LD Sbjct: 1526 EE----------NLEIF-PVDLQKKAGRGLGL---SIVGKRNGSGVFISDIVKGGAADLD 1571 Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439 GRL GD+I+ ++ + + V TIL C G V + + R Sbjct: 1572 GRLIQGDQILSVNGEDMRNASQETVATILK-CAQGLVQLEIGR 1613 Score = 77.8 bits (190), Expect = 6e-14 Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 24/203 (11%) Query: 226 GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQ 285 GLGF IVGGK S G+ V+TI GG A DGRLQ GD IL++ G ++ G+T + Q Sbjct: 257 GLGFGIVGGKTS-----GVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQ 311 Query: 286 KFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPIST 345 + +VR + P+ ++PP +L + + A + P + S Sbjct: 312 VLRNCGN-----SVRMLVARDPAGDISVTPPAPAALPVAL------PTVASKGPGSDSSL 360 Query: 346 AKPNYRIMVEVSLQKEAGVGLGI---GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCG 402 + V L ++ G LGI G + SGI+V ++ PGS A+ +G ++ Sbjct: 361 FE-----TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVN 415 Query: 403 DEIVEISDSPVHCLTLNEVYTIL 425 D+IV + + ++V +L Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVL 438 Score = 77.0 bits (188), Expect = 1e-13 Identities = 77/345 (22%), Positives = 142/345 (41%), Gaps = 46/345 (13%) Query: 978 KLLDEKTSKLYSISSQVSSAVMKS------LLCLPSSISCAQTPCIPKEGASPTSSSNED 1031 +LL+ LY S Q +SA++K+ L+ + + + Q P S + SS ED Sbjct: 1286 ELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIED 1345 Query: 1032 SAAN---GSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSE 1088 + S E +++ G L E + +++ K+ S S + ++ SS Sbjct: 1346 QSGTEPISSEEDGSVEVGIK-QLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSY 1404 Query: 1089 ELKKL-------IEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITV 1141 + +D AT + G + I + +GLG S+ GG D I + Sbjct: 1405 HSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVI 1464 Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPE 1201 H V+ G A+++G + G+++L +NG L+ ++H +A+ LRQ + + V+ Sbjct: 1465 HEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY------- 1517 Query: 1202 AMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKP 1260 + + V L+K + GLG S+ G + Sbjct: 1518 -----------------RDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNG----SG 1556 Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + I+ I KG A++ + GD+IL + G M+ ++ I+K Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601 Score = 73.9 bits (180), Expect = 9e-13 Identities = 55/215 (25%), Positives = 97/215 (45%), Gaps = 22/215 (10%) Query: 1120 EGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDAL 1179 +G+GLGF + GG + + V + P GLA ++G +Q G+ +L I G +++G T Sbjct: 254 DGSGLGFGIVGG---KTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVA 310 Query: 1180 AILRQ---------AREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 1230 +LR AR+P + V TP A L + + AS SD S+ T Sbjct: 311 QVLRNCGNSVRMLVARDPAGDISV----TPPAPAALPVALPTVASKGPGSDSSLFETYNV 366 Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLHGDKP--LTINRIFKGAASEQSETVQPGDEILQLG 1288 + + K LG + G G+ H + + + I G+A+ + +Q D+I+ + Sbjct: 367 EL----VRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422 Query: 1289 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQS 1323 G +QG + +++ ++RRK+ S Sbjct: 423 GVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSS 457 Score = 67.8 bits (164), Expect = 7e-11 Identities = 62/269 (23%), Positives = 121/269 (44%), Gaps = 27/269 (10%) Query: 1041 SALDTGFSLNLSELREYTEG-LTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKV 1099 S F + L +T+G +T ++S++ L +E+ +I+++ Sbjct: 69 SDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVIQQM-- 126 Query: 1100 LDEATLKQLDGIHVTILHKEEGAGLGFSLAG--GADLENKVITVHRVFPNGLASQEGTIQ 1157 A +Q++ I + + GLGFS+ +L I V V P +A ++ ++ Sbjct: 127 ---AQGRQIEYIDI---ERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLK 180 Query: 1158 KGNEVLSINGKSL-KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216 + +++L+IN L + +H A+A+L+Q + ++ + T S+ S+ Sbjct: 181 ENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAREPV----------HTKSSTSS 230 Query: 1217 SAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSE 1276 S E+ V V L +GLGF + GGK S + + I G +++ Sbjct: 231 SLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTS-----GVVVRTIVPGGLADRDG 285 Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 +Q GD IL++GGT +QG+T + +++ Sbjct: 286 RLQTGDHILKIGGTNVQGMTSEQVAQVLR 314 Score = 65.5 bits (158), Expect = 3e-10 Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 29/232 (12%) Query: 1101 DEATLKQLDGIHV--TILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQK 1158 DEA + + + + L K+ G GLG S+ G + + + + G A +G + + Sbjct: 1519 DEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRN--GSGVFISDIVKGGAADLDGRLIQ 1576 Query: 1159 GNEVLSINGKSLKGTTHHDALAILRQAREPRQAVI--------VTRKLTPEAMPDLNSST 1210 G+++LS+NG+ ++ + IL+ A+ Q I + + T + S Sbjct: 1577 GDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSA 1636 Query: 1211 DSAASASAA---------------SDVSVESTA-EATVCTVTLEK-MSAGLGFSLEGGKG 1253 S+ S A SD S +++ + TV + + +S LG S+ GG+G Sbjct: 1637 HSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRG 1696 Query: 1254 SLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 S GD P+ I I + +++ ++ GD I+ + G + GL+ + N++K Sbjct: 1697 SPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748 Score = 63.9 bits (154), Expect = 1e-09 Identities = 60/226 (26%), Positives = 95/226 (42%), Gaps = 29/226 (12%) Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGL 278 L K +GLG SIVG ++ G+++ I GGAA DGRL +GD+IL +NGE M Sbjct: 1536 LQKKAGRGLGLSIVGKRNGS----GVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNA 1591 Query: 279 THQDALQKFKQAKKGLLTLTV---------RTRLTAPPSLCSHLSPPLCRSLSSSTCITK 329 + Q+ + + +GL+ L + R T+ S S S S + IT Sbjct: 1592 S-QETVATILKCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITG 1650 Query: 330 DSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC--------SVPYFQCISG 381 + + S P V + +E LGI + +P Sbjct: 1651 LQNLVGTKRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIP------- 1703 Query: 382 IFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427 +F+ + VA +L+ GD IV I+ P+ L+ +V +L + Sbjct: 1704 VFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749 Score = 62.0 bits (149), Expect = 4e-09 Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 73/301 (24%) Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 +I+ ++ GLG S+ G KD + I+V I G AAADGR++ GDE+LE+N + + Sbjct: 1238 HIIELEKDKNGLGLSLAGNKDR--SRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295 Query: 276 AGLTHQDALQKFKQAKKGLLTLTVR-----TRLTAPPSLCSHLSPPLCRSLSSSTCITK- 329 G +HQ+A K A + + +R ++ P SP S + I+ Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSE 1355 Query: 330 -------------DSSSFAL-------------------ESPSAPIST------------ 345 +S SF L E P AP S+ Sbjct: 1356 EDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYG 1415 Query: 346 --------------AKPNYRIMVEVSLQKEAGVGLGI-GLCSVPYFQCISGIFVHTLSPG 390 P +++E+S + +G+GL I G P ++ I +H + Sbjct: 1416 GFQAPLSVDPATCPIVPGQEMIIEIS-KGRSGLGLSIVGGKDTP----LNAIVIHEVYEE 1470 Query: 391 SVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQL 450 A DGRL GD+I+E++ + + E T L P V ++V R E+ L Sbjct: 1471 GAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQ-TPQKVRLVVYRDEAHYRDEENL 1529 Query: 451 K 451 + Sbjct: 1530 E 1530 Score = 56.6 bits (135), Expect = 2e-07 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 10/129 (7%) Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170 +H+ L K++ GLG SLAG D I V + P G A+ +G ++ G+E+L IN + L Sbjct: 1237 LHIIELEKDKN-GLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295 Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRK-------LTPEAMPDLNSSTDSAASASAASDVS 1223 G +H +A AI++ A + V + + +TP +P +SS S S +S Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVP--SSSPSSIEDQSGTEPIS 1353 Query: 1224 VESTAEATV 1232 E V Sbjct: 1354 SEEDGSVEV 1362 Score = 56.2 bits (134), Expect = 2e-07 Identities = 46/196 (23%), Positives = 85/196 (43%), Gaps = 11/196 (5%) Query: 1141 VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTP 1200 + + G G +Q +E+L +NG L G + +A++ L++ P V R Sbjct: 583 ISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDD 642 Query: 1201 EAMPDLNSSTDSAASASAAS---DVSVESTAEATVCT-------VTLEKMSAGLGFSLEG 1250 EA D T+++ + DV+ E + + V L K GLGFS+ Sbjct: 643 EASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD 702 Query: 1251 GKGSLHGDKPLTINR-IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD 1309 + L + + + R + +E+S + PGD ++ + + + EA I+KA+P Sbjct: 703 YQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPP 762 Query: 1310 GPVTIVIRRKSLQSKE 1325 G V + I + ++ E Sbjct: 763 GLVHLGICKPLVEDNE 778 Score = 54.7 bits (130), Expect = 6e-07 Identities = 30/89 (33%), Positives = 50/89 (56%), Gaps = 1/89 (1%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LG SI GG+ S G I +++ I A G AA +L+ GD I+ +NG+ + GL+H D + Sbjct: 1687 LGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNL 1746 Query: 287 FKQA-KKGLLTLTVRTRLTAPPSLCSHLS 314 K A + +L + T ++A + ++S Sbjct: 1747 LKNAYGRIILQVVADTNISAIAAQLENMS 1775 Score = 53.5 bits (127), Expect = 1e-06 Identities = 60/254 (23%), Positives = 107/254 (42%), Gaps = 47/254 (18%) Query: 227 LGFSIVGGKDSIYGPI------GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTH 280 LG SIVGG+ I GI++K + A L+ GD+ILE++G + +H Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138 Query: 281 QDALQKFKQAKKGLL----TLTVRTRL----------------------------TAPPS 308 +A++ K A ++ +L+ R+ TAPP Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198 Query: 309 LCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGI 368 + PP ++L+ + ++ +F + + I + L+K+ GLG+ Sbjct: 1199 M---KLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHI---IELEKDKN-GLGL 1251 Query: 369 GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428 L +S IFV ++P A DGR+R GDE++EI++ ++ + I+ Sbjct: 1252 SLAGNKDRSRMS-IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTA 1310 Query: 429 DPGPVPIIVSRHPD 442 P V ++ R+ D Sbjct: 1311 -PSKVKLVFIRNED 1323 Score = 50.8 bits (120), Expect = 8e-06 Identities = 77/316 (24%), Positives = 132/316 (41%), Gaps = 65/316 (20%) Query: 183 PAGKAAGTSRPTRSLSTA--QLVQPSGGLQASVIS--NIVLMKGQAKGLGFSIVG--GKD 236 PAG + T +L A + G +S+ N+ L++ + LG IVG G Sbjct: 328 PAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTS 387 Query: 237 SIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLT 296 GIYVK+I G AA +G +Q D+I+ ++G ++ G + D ++ + A + + Sbjct: 388 HTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHL 447 Query: 297 LTVRTRLTA------PPS----LCSHLSPP---LCRSLSSSTCI-------------TKD 330 VR + ++ PPS + L PP L ++ + T + K+ Sbjct: 448 TLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKN 507 Query: 331 SSSFALES----PSAPISTAK--------PNYRIMV---------EVSLQKEA------G 363 + ALE P +P + K P+Y +MV + LQK + Sbjct: 508 DNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHT 567 Query: 364 VGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYT 423 + LG+ + S IS I +S G V L G L+ DE++E++ ++ + E + Sbjct: 568 LRLGVEVDSFDGHHYISSI----VSGGPVDTL-GLLQPEDELLEVNGMQLYGKSRREAVS 622 Query: 424 ILSHCDPGPVPIIVSR 439 L P P ++ R Sbjct: 623 FLKEVPP-PFTLVCCR 637 Score = 50.1 bits (118), Expect = 1e-05 Identities = 50/254 (19%), Positives = 96/254 (37%), Gaps = 52/254 (20%) Query: 1116 LHKEEGAGLGFSLAGGADL--------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167 + +E LG S+ GG + E K I + +V + A + ++ G+++L ++G Sbjct: 1071 IFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSG 1130 Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS---------- 1217 L+ +H +A+ ++ A P ++ + TP +P++++ + Sbjct: 1131 VDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEK 1190 Query: 1218 ----------------AASDVSVESTAE----------------ATVCTVTLEKMSAGLG 1245 A +D S E+ E + + LEK GLG Sbjct: 1191 RQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLG 1250 Query: 1246 FSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 SL G K + + I + ++ GDE+L++ + G + A IIK Sbjct: 1251 LSLAGNKD--RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIK 1308 Query: 1306 ALPDGPVTIVIRRK 1319 P + IR + Sbjct: 1309 TAPSKVKLVFIRNE 1322 Score = 46.6 bits (109), Expect = 2e-04 Identities = 47/190 (24%), Positives = 76/190 (40%), Gaps = 7/190 (3%) Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLT 304 Y+ +I +GG G LQ DE+LE+NG + G + ++A+ K+ + R Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641 Query: 305 APPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEA-G 363 S+ P + T + + E ++ P +I V L K+ G Sbjct: 642 DEASVD---EPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKI---VELVKDCKG 695 Query: 364 VGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYT 423 +G I P S I + +L VA G L GD +V +++ + +L E Sbjct: 696 LGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVE 755 Query: 424 ILSHCDPGPV 433 IL PG V Sbjct: 756 ILKAVPPGLV 765 Score = 43.9 bits (102), Expect = 0.001 Identities = 24/93 (25%), Positives = 45/93 (48%), Gaps = 4/93 (4%) Query: 1116 LHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLK 1171 L +++G LG + G E I V + P A G IQ +++++++G +++ Sbjct: 368 LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQ 427 Query: 1172 GTTHHDALAILRQAREPRQAVIVTRKLTPEAMP 1204 G +HD + +LR A + +V RK + P Sbjct: 428 GFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSP 460 Score = 41.6 bits (96), Expect = 0.005 Identities = 21/72 (29%), Positives = 44/72 (61%), Gaps = 2/72 (2%) Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 +++E LG S+AGG + L + + + + +G+A++ ++ G+ ++SING+ L G Sbjct: 1679 INRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGL 1738 Query: 1174 THHDALAILRQA 1185 +H D + +L+ A Sbjct: 1739 SHADVVNLLKNA 1750 Score = 37.0 bits (84), Expect = 0.13 Identities = 23/86 (26%), Positives = 43/86 (50%), Gaps = 8/86 (9%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPL---TINRIFKGAASEQSETVQPGDEILQLGGTA 1291 + + K +GLG S+ GGK D PL I+ +++ A+ + + GD+IL++ G Sbjct: 1438 IEISKGRSGLGLSIVGGK-----DTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVD 1492 Query: 1292 MQGLTRFEAWNIIKALPDGPVTIVIR 1317 ++ + EA ++ P +V R Sbjct: 1493 LRNSSHEEAITALRQTPQKVRLVVYR 1518 Score = 36.6 bits (83), Expect = 0.17 Identities = 24/84 (28%), Positives = 42/84 (50%), Gaps = 1/84 (1%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYV-KTIFAGGAAAADGRLQEGDEILELNGESM 275 IV + KGLGFSI+ +D + + V +++ A G A G L GD ++ +N + Sbjct: 686 IVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCL 745 Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299 + +A++ K GL+ L + Sbjct: 746 DNTSLAEAVEILKAVPPGLVHLGI 769 Score = 34.7 bits (78), Expect = 0.63 Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 7/102 (6%) Query: 1218 AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSET 1277 A D + AE + L + LG ++ G + I+ I G + Sbjct: 544 ATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHY------ISSIVSGGPVDTLGL 597 Query: 1278 VQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319 +QP DE+L++ G + G +R EA + +K +P P T+V R+ Sbjct: 598 LQPEDELLEVNGMQLYGKSRREAVSFLKEVPP-PFTLVCCRR 638 Score = 33.1 bits (74), Expect = 1.8 Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 26/137 (18%) Query: 1050 NLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD 1109 ++ E R L E + D + D ++ + ++L S E K++E VK Sbjct: 645 SVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEV--KIVELVK----------- 691 Query: 1110 GIHVTILHKEEGAGLGFSLAG---GADLENKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166 + GLGFS+ D VI + + +G+A + G + G+ ++S+N Sbjct: 692 ----------DCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVN 741 Query: 1167 GKSLKGTTHHDALAILR 1183 L T+ +A+ IL+ Sbjct: 742 EYCLDNTSLAEAVEILK 758 Score = 31.6 bits (70), Expect = 5.3 Identities = 17/90 (18%), Positives = 49/90 (54%), Gaps = 2/90 (2%) Query: 1241 SAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAM-QGLTRFE 1299 + GLGFS+ + G + + + G+ +++ + ++ D+IL + T + Q ++ + Sbjct: 142 TGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQ 201 Query: 1300 AWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329 A +++ G + +++ R+ + +K +T++ Sbjct: 202 AIALLQQ-TTGSLRLIVAREPVHTKSSTSS 230 >gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo sapiens] Length = 1104 Score = 82.0 bits (201), Expect = 3e-15 Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%) Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279 +K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339 ++ + + K+G V R H P R L D + +LE+ Sbjct: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491 Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397 + ++ E+ L GLG+ L + + GIF+ ++ G A DG Sbjct: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542 Query: 398 RLRCGDEIVEIS 409 RLR D+++ ++ Sbjct: 543 RLRMNDQLIAVN 554 Score = 71.2 bits (173), Expect = 6e-12 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%) Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198 I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V + Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 Query: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257 +P +L D A +S+E++ + T + SAGLG SL+G K G Sbjct: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522 Query: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310 D + I I G A+ + ++ D+++ + G ++ G + EA ++ G Sbjct: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582 Query: 1311 PVTIVIRRKSLQSKETTA 1328 + +VI R+ + E A Sbjct: 583 MIQLVILRRPERPMEDPA 600 Score = 63.5 bits (153), Expect = 1e-09 Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 I L + GLG S+ G K G +GI++K+I GGAA DGRL+ D+++ +NGES+ Sbjct: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558 Query: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326 G ++ +A++ +++ +G++ L + R P P+ C S P + ++ Sbjct: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618 Query: 327 ITKDSSSFALESPSAPISTAKP 348 ++ + + L P+ T P Sbjct: 619 TSRRNDNSILH----PLGTCSP 636 Score = 46.2 bits (108), Expect = 2e-04 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%) Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236 DA A L+Q + PR + + +P P + S A + Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385 Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296 L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319 + E ++++ G ++VI R+ Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469 Score = 45.4 bits (106), Expect = 4e-04 Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%) Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255 + T L P S ++ V + G+ LG +V S+ G I G++++ I + Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242 Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311 +G E + I+++N + T A F+QA K L L + R S+ Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302 Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348 L+ PP+ +L+ + D+S+ + SP P KP Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362 Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 + + +++ L+K G+G V I G IFV + P Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451 A DGRL+ GD I+E++ V T E+ +L G +V + ++LK Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479 >gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo sapiens] Length = 1136 Score = 82.0 bits (201), Expect = 3e-15 Identities = 59/192 (30%), Positives = 90/192 (46%), Gaps = 25/192 (13%) Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279 +K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339 ++ + + K+G V R H P R L D + +LE+ Sbjct: 446 QEELVAMLRSTKQGETASLVIARQE------GHFLP---RELKGE----PDCCALSLET- 491 Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCIS--GIFVHTLSPGSVAHLDG 397 + ++ E+ L GLG+ L + + GIF+ ++ G A DG Sbjct: 492 ---------SEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDG 542 Query: 398 RLRCGDEIVEIS 409 RLR D+++ ++ Sbjct: 543 RLRMNDQLIAVN 554 Score = 71.2 bits (173), Expect = 6e-12 Identities = 51/198 (25%), Positives = 94/198 (47%), Gaps = 15/198 (7%) Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198 I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V + Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 Query: 1199 TPEAMP-DLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHG 1257 +P +L D A +S+E++ + T + SAGLG SL+G K G Sbjct: 470 EGHFLPRELKGEPDCCA-------LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETG 522 Query: 1258 -DKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------G 1310 D + I I G A+ + ++ D+++ + G ++ G + EA ++ G Sbjct: 523 TDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRG 582 Query: 1311 PVTIVIRRKSLQSKETTA 1328 + +VI R+ + E A Sbjct: 583 MIQLVILRRPERPMEDPA 600 Score = 63.5 bits (153), Expect = 1e-09 Identities = 40/142 (28%), Positives = 73/142 (51%), Gaps = 14/142 (9%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGP-IGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 I L + GLG S+ G K G +GI++K+I GGAA DGRL+ D+++ +NGES+ Sbjct: 499 IPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESL 558 Query: 276 AGLTHQDALQKFKQAK------KGLLTLTVRTRLTAP---PSLCSHLSPPLCRSLSSSTC 326 G ++ +A++ +++ +G++ L + R P P+ C S P + ++ Sbjct: 559 LGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVT 618 Query: 327 ITKDSSSFALESPSAPISTAKP 348 ++ + + L P+ T P Sbjct: 619 TSRRNDNSILH----PLGTCSP 636 Score = 46.2 bits (108), Expect = 2e-04 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%) Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236 DA A L+Q + PR + + +P P + S A + Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385 Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296 L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319 + E ++++ G ++VI R+ Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469 Score = 45.4 bits (106), Expect = 4e-04 Identities = 67/300 (22%), Positives = 114/300 (38%), Gaps = 48/300 (16%) Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255 + T L P S ++ V + G+ LG +V S+ G I G++++ I + Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242 Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311 +G E + I+++N + T A F+QA K L L + R S+ Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302 Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348 L+ PP+ +L+ + D+S+ + SP P KP Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362 Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 + + +++ L+K G+G V I G IFV + P Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451 A DGRL+ GD I+E++ V T E+ +L G +V + ++LK Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQEGHFLPRELK 479 >gi|45827729 scribble isoform b [Homo sapiens] Length = 1630 Score = 80.9 bits (198), Expect = 8e-15 Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%) Query: 801 NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 860 +R S + L P A+ E G RA+ S ++ S E S P Sbjct: 443 SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497 Query: 861 RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 914 QP SG PL EE R S G R +A T+ +PE + + EA Sbjct: 498 ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551 Query: 915 RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 973 G E Q + T+ D LL + EE Q +P R R L R Sbjct: 552 TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606 Query: 974 SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 1026 + K K + IS + +LL + P P +P + Sbjct: 607 TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657 Query: 1027 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 1086 E+ GS + + E R E + +ED +G ++ S SV + Sbjct: 658 QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709 Query: 1087 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 1141 + LIE ++ +E + +TIL + GLG S+AGG +++ I + Sbjct: 710 DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760 Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 1188 RV G A++ G ++ G+++L +NG +L+G HH+A+ LR A EP Sbjct: 761 SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819 Query: 1189 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 1247 AV +T L PE D S + + ES V L + GLGFS Sbjct: 820 ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875 Query: 1248 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 1289 + GGKGS GD + ++RI +G A+ ++ T+Q GD +L + G Sbjct: 876 IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920 Score = 75.1 bits (183), Expect = 4e-13 Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 17/240 (7%) Query: 216 NIVLMKGQAKGLGFSIVGGKDSI---YGPIGIYVKTIFAGGAAAADGRLQEGDEILELNG 272 ++ + +GLGFSI GGK S G GI+V I GGAA G LQ GD +L +NG Sbjct: 861 HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920 Query: 273 ESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAPPSLCSHLSPPLCR-SLSSSTCITKD 330 + H A+ A + L R PPS H SPP + +S T T Sbjct: 921 VDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980 Query: 331 SSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGL------CSVPYFQCISGIFV 384 +PS + + Y + E+ L + AG LG+ + S P+ G+F+ Sbjct: 981 VPGLPSLAPSLLAAALEGPYPV-EEIRLPR-AGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038 Query: 385 HTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE-VYTILSHCDPGPVPIIVSRHPDP 443 + P +A G LR GD I+ ++ V T E V +L C + ++V R P P Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAP 1095 Score = 72.0 bits (175), Expect = 4e-12 Identities = 115/503 (22%), Positives = 180/503 (35%), Gaps = 97/503 (19%) Query: 227 LGFSIVGGKDSIYGPIGI-----YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281 LG SIVGG D P G+ ++ + G AA G L+ GD IL +NG+ + THQ Sbjct: 1014 LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQ 1072 Query: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341 +A+ + L +L VR R APP L CI K Sbjct: 1073 EAVSALLRPCLEL-SLLVR-RDPAPPGL-------------RELCIQK------------ 1105 Query: 342 PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRC 401 P R+ + + G G P GIF+ +SP A DGRLR Sbjct: 1106 -----APGERLGISIR-------GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153 Query: 402 GDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENT 461 G ++E++ + LT E +L ++ + S E + N Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF---EASTDAALEVSPGVIANP 1210 Query: 462 KFGKERHQWSLEGVKRLESS------------------WHGRPTLEKEREKNSAPPHRRA 503 H+ SLE + ++ W T R RA Sbjct: 1211 FAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRA 1270 Query: 504 QKVMIRSSSDSSYMSGSPGG----SPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIAS 559 + + S SG+ GG SP S S ++P S ++ A ++ + Sbjct: 1271 LAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYR-AFAAVPT 1329 Query: 560 SRLPQES---PPLPESRDSHPPLRLK---KSFEILVRKPMSSKPKPPPRKYFKSDSDPQK 613 S P+++ PP P S L + K FE+ VR P + + PP++ +D + Sbjct: 1330 SHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQA---EGPPKRVSLVGADDLR 1386 Query: 614 SLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSST 673 ++E E Q+ ++L + A A G +G + + Sbjct: 1387 KMQEEEARKLQ---------QKRAQML------REAAEAGAEARLALDGETLGEEEQE-- 1429 Query: 674 EGEPGWRRASPVTQTSPIKHPLL 696 + +P W SP ++ SP P L Sbjct: 1430 DEQPPWASPSPTSRQSPASPPPL 1452 Score = 70.9 bits (172), Expect = 8e-12 Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 22/237 (9%) Query: 223 QAKGLGFSIVGGKDSIY---GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279 Q GLG SI GGK S GI++ + G AA G ++ GD++LE+NG ++ G Sbjct: 734 QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAE 792 Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339 H +A++ + A + R R+ P + + PL S ++ L P Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVT--ITPLRPEDDYS---PRERRGGGLRLP 847 Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAHLDG 397 P + P + V + E G+G I G S PY +GIFV ++ G AH G Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907 Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDP-----------GPVPIIVSRHPDP 443 L+ GD ++ I+ V + ++L+ P GP+P H P Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964 Score = 59.7 bits (143), Expect = 2e-08 Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%) Query: 1112 HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166 HV L + E GLGFS+AGG + I V R+ G A + GT+Q G+ VLSIN Sbjct: 861 HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919 Query: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 1217 G + H A+++L A P A+++ R+ L P +P + T + A+ S Sbjct: 920 GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978 Query: 1218 ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 1265 A S ++ V + L + LG S+ G GS H P + Sbjct: 979 PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036 Query: 1266 -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 + +G A+ ++ GD IL + G ++ T EA + + P +++++RR Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091 Score = 51.6 bits (122), Expect = 5e-06 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%) Query: 1070 GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 1125 GD +GQ V E + L+ L+ + L + D G+ + K G LG Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112 Query: 1126 FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 S+ GGA D ++ I + +V P G A ++G ++ G +L +N +SL G TH + Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 1217 A+ +LR V LT +STD+A S Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203 Score = 49.7 bits (117), Expect = 2e-05 Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYG------PIGIYVKTIFAGGAAAADGRLQEGDEI 267 + + + K + LG SI GG G GI++ + GAA DGRL+ G + Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRL 1157 Query: 268 LELNGESMAGLTHQDALQKFKQAKKGLLTL 297 LE+N +S+ GLTH +A+Q + L L Sbjct: 1158 LEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187 Score = 43.1 bits (100), Expect = 0.002 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%) Query: 1215 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 1270 S A+++ +E + E T+T+ + + GLG S+ GGKGS D+ + I+R+ + Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767 Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 1300 + ++ V+ GD++L++ G A+QG EA Sbjct: 768 PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796 >gi|45827731 scribble isoform a [Homo sapiens] Length = 1655 Score = 80.9 bits (198), Expect = 8e-15 Identities = 136/525 (25%), Positives = 206/525 (39%), Gaps = 83/525 (15%) Query: 801 NRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQ 860 +R S + L P A+ E G RA+ S ++ S E S P Sbjct: 443 SRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACP----- 497 Query: 861 RLSLQPSSGEAAKPLGKHEEGRFSGLLG-----RGAAPTLVPQQPEQVLSSGSPAAS-EA 914 QP SG PL EE R S G R +A T+ +PE + + EA Sbjct: 498 ---CQPDSGS---PLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEA 551 Query: 915 RDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPV-LKMPSQRARSFPLTRSQ 973 G E Q + T+ D LL + EE Q +P R R L R Sbjct: 552 TTAGGEEDAEEDYQ--EPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQR---LIRKD 606 Query: 974 SCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIP-------KEGASPTS 1026 + K K + IS + +LL + P P +P + Sbjct: 607 TPHYK-------KHFKISKLPQPEAVVALL--QGMQPDGEGPVAPGGWHNGPHAPWAPRA 657 Query: 1027 SSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLS 1086 E+ GS + + E R E + +ED +G ++ S SV + Sbjct: 658 QKEEEEEEEGSPQEEEEEEE-----EENRAEEEEASTEEEDKEG---AVVSAPSVKGVSF 709 Query: 1087 SEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADL-----ENKVITV 1141 + LIE ++ +E + +TIL + GLG S+AGG +++ I + Sbjct: 710 DQANNLLIEPARIEEEE-------LTLTILRQT--GGLGISIAGGKGSTPYKGDDEGIFI 760 Query: 1142 HRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAR-------------EP 1188 RV G A++ G ++ G+++L +NG +L+G HH+A+ LR A EP Sbjct: 761 SRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEP 819 Query: 1189 RQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT-LEKMSAGLGFS 1247 AV +T L PE D S + + ES V L + GLGFS Sbjct: 820 ENAVTIT-PLRPE---DDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFS 875 Query: 1248 LEGGKGSL---HGDKPLTINRIFKGAASEQSETVQPGDEILQLGG 1289 + GGKGS GD + ++RI +G A+ ++ T+Q GD +L + G Sbjct: 876 IAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920 Score = 75.1 bits (183), Expect = 4e-13 Identities = 73/240 (30%), Positives = 105/240 (43%), Gaps = 17/240 (7%) Query: 216 NIVLMKGQAKGLGFSIVGGKDSI---YGPIGIYVKTIFAGGAAAADGRLQEGDEILELNG 272 ++ + +GLGFSI GGK S G GI+V I GGAA G LQ GD +L +NG Sbjct: 861 HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSING 920 Query: 273 ESMAGLTHQDALQKFKQAKKGLLTLTVR-TRLTAPPSLCSHLSPPLCR-SLSSSTCITKD 330 + H A+ A + L R PPS H SPP + +S T T Sbjct: 921 VDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPG 980 Query: 331 SSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGL------CSVPYFQCISGIFV 384 +PS + + Y + E+ L + AG LG+ + S P+ G+F+ Sbjct: 981 VPGLPSLAPSLLAAALEGPYPV-EEIRLPR-AGGPLGLSIVGGSDHSSHPFGVQEPGVFI 1038 Query: 385 HTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNE-VYTILSHCDPGPVPIIVSRHPDP 443 + P +A G LR GD I+ ++ V T E V +L C + ++V R P P Sbjct: 1039 SKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAP 1095 Score = 72.0 bits (175), Expect = 4e-12 Identities = 115/503 (22%), Positives = 180/503 (35%), Gaps = 97/503 (19%) Query: 227 LGFSIVGGKDSIYGPIGI-----YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281 LG SIVGG D P G+ ++ + G AA G L+ GD IL +NG+ + THQ Sbjct: 1014 LGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQ 1072 Query: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341 +A+ + L +L VR R APP L CI K Sbjct: 1073 EAVSALLRPCLEL-SLLVR-RDPAPPGL-------------RELCIQK------------ 1105 Query: 342 PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRC 401 P R+ + + G G P GIF+ +SP A DGRLR Sbjct: 1106 -----APGERLGISIR-------GGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153 Query: 402 GDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENT 461 G ++E++ + LT E +L ++ + S E + N Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGF---EASTDAALEVSPGVIANP 1210 Query: 462 KFGKERHQWSLEGVKRLESS------------------WHGRPTLEKEREKNSAPPHRRA 503 H+ SLE + ++ W T R RA Sbjct: 1211 FAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRA 1270 Query: 504 QKVMIRSSSDSSYMSGSPGG----SPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIAS 559 + + S SG+ GG SP S S ++P S ++ A ++ + Sbjct: 1271 LAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYR-AFAAVPT 1329 Query: 560 SRLPQES---PPLPESRDSHPPLRLK---KSFEILVRKPMSSKPKPPPRKYFKSDSDPQK 613 S P+++ PP P S L + K FE+ VR P + + PP++ +D + Sbjct: 1330 SHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQA---EGPPKRVSLVGADDLR 1386 Query: 614 SLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSST 673 ++E E Q+ ++L + A A G +G + + Sbjct: 1387 KMQEEEARKLQ---------QKRAQML------REAAEAGAEARLALDGETLGEEEQE-- 1429 Query: 674 EGEPGWRRASPVTQTSPIKHPLL 696 + +P W SP ++ SP P L Sbjct: 1430 DEQPPWASPSPTSRQSPASPPPL 1452 Score = 70.9 bits (172), Expect = 8e-12 Identities = 65/237 (27%), Positives = 101/237 (42%), Gaps = 22/237 (9%) Query: 223 QAKGLGFSIVGGKDSIY---GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279 Q GLG SI GGK S GI++ + G AA G ++ GD++LE+NG ++ G Sbjct: 734 QTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAE 792 Query: 280 HQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESP 339 H +A++ + A + R R+ P + + PL S ++ L P Sbjct: 793 HHEAVEALRGAGTAVQMRVWRERMVEPENAVT--ITPLRPEDDYS---PRERRGGGLRLP 847 Query: 340 SAPISTAKPNYRIMVEVSLQKEAGVGLGI--GLCSVPYFQCISGIFVHTLSPGSVAHLDG 397 P + P + V + E G+G I G S PY +GIFV ++ G AH G Sbjct: 848 LLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAG 907 Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDP-----------GPVPIIVSRHPDP 443 L+ GD ++ I+ V + ++L+ P GP+P H P Sbjct: 908 TLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964 Score = 59.7 bits (143), Expect = 2e-08 Identities = 65/238 (27%), Positives = 105/238 (44%), Gaps = 38/238 (15%) Query: 1112 HVTILHKEEGAGLGFSLAGGADLE-----NKVITVHRVFPNGLASQEGTIQKGNEVLSIN 1166 HV L + E GLGFS+AGG + I V R+ G A + GT+Q G+ VLSIN Sbjct: 861 HVACLARSE-RGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSIN 919 Query: 1167 GKSLKGTTHHDALAILRQAREPRQAVIVTRK----LTPEAMPDLNSSTDSAASAS----- 1217 G + H A+++L A P A+++ R+ L P +P + T + A+ S Sbjct: 920 GVDVTEARHDHAVSLL-TAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTAT 978 Query: 1218 ---------AASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINR--- 1265 A S ++ V + L + LG S+ G GS H P + Sbjct: 979 PGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVG--GSDHSSHPFGVQEPGV 1036 Query: 1266 -----IFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 + +G A+ ++ GD IL + G ++ T EA + + P +++++RR Sbjct: 1037 FISKVLPRGLAARSG--LRVGDRILAVNGQDVRDATHQEAVSAL-LRPCLELSLLVRR 1091 Score = 51.6 bits (122), Expect = 5e-06 Identities = 45/160 (28%), Positives = 70/160 (43%), Gaps = 23/160 (14%) Query: 1070 GDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLD----GIHVTILHKEEGAGLG 1125 GD +GQ V E + L+ L+ + L + D G+ + K G LG Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPC--LELSLLVRRDPAPPGLRELCIQKAPGERLG 1112 Query: 1126 FSLAGGA--------DLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 S+ GGA D ++ I + +V P G A ++G ++ G +L +N +SL G TH + Sbjct: 1113 ISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASAS 1217 A+ +LR V LT +STD+A S Sbjct: 1173 AVQLLRS---------VGDTLTVLVCDGFEASTDAALEVS 1203 Score = 49.7 bits (117), Expect = 2e-05 Identities = 30/90 (33%), Positives = 45/90 (50%), Gaps = 6/90 (6%) Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYG------PIGIYVKTIFAGGAAAADGRLQEGDEI 267 + + + K + LG SI GG G GI++ + GAA DGRL+ G + Sbjct: 1098 LRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRL 1157 Query: 268 LELNGESMAGLTHQDALQKFKQAKKGLLTL 297 LE+N +S+ GLTH +A+Q + L L Sbjct: 1158 LEVNQQSLLGLTHGEAVQLLRSVGDTLTVL 1187 Score = 43.1 bits (100), Expect = 0.002 Identities = 28/90 (31%), Positives = 52/90 (57%), Gaps = 5/90 (5%) Query: 1215 SASAASDVSVE-STAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGA 1270 S A+++ +E + E T+T+ + + GLG S+ GGKGS D+ + I+R+ + Sbjct: 708 SFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEG 767 Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEA 1300 + ++ V+ GD++L++ G A+QG EA Sbjct: 768 PAARAG-VRVGDKLLEVNGVALQGAEHHEA 796 >gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] Length = 904 Score = 80.1 bits (196), Expect = 1e-14 Identities = 70/246 (28%), Positives = 106/246 (43%), Gaps = 14/246 (5%) Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271 I I L+KG KGLGFSI GG I G IYV I GGAA DG+LQ GD++L +N Sbjct: 317 IMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375 Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325 + +TH++A+ K K T APP + + S P+ +S S+ Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435 Query: 326 CITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVH 385 + + +S A SP + + GLG + + GIF+ Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG---GEDGEGIFIS 492 Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445 + G A L G LR GD I+ ++ + + + L + G IV+++ + Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEY 550 Query: 446 SEQQLK 451 S + K Sbjct: 551 SRFEAK 556 Score = 71.6 bits (174), Expect = 5e-12 Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ G A+Q+G ++ + +L +N ++ TH Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + + RK E + ++ L Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD++L + ++ + Sbjct: 323 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382 Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331 T EA +K D V + S+ + A D Sbjct: 383 THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418 Score = 63.9 bits (154), Expect = 1e-09 Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%) Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N Sbjct: 225 ITLERGNS-GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 + +TH A++ K+A ++ L V+ R Sbjct: 284 VRDVTHSKAVEALKEA-GSIVRLYVKRR-------------------------------- 310 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 KP ++E+ L K GLG + Q I G I+V + G Sbjct: 311 ------------KPVSEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427 AH DG+L+ GD+++ +++ + +T E T L + Sbjct: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKN 393 Score = 57.0 bits (136), Expect = 1e-07 Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ TH +A Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387 Query: 1179 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 1215 + L+ + + + P +M PD+ +S+ + AS Sbjct: 388 VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443 Query: 1216 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 1271 + S VS + + V L + S GLGF++ GG+ + + I+ I G Sbjct: 444 PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499 Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 ++ S ++ GD I+ + ++ + +A +K Sbjct: 500 ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533 Score = 49.7 bits (117), Expect = 2e-05 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 +LH+ GLGF++ GG D E I + + G A G ++KG+ ++S+N L+ + Sbjct: 468 VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A A L+ A QAV + + PE Sbjct: 525 HEQAAAALKNA---GQAVTIVAQYRPE 548 Score = 44.7 bits (104), Expect = 6e-04 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%) Query: 1188 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 1247 P + ++ + P + +TDS + + + + E +TLE+ ++GLGFS Sbjct: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237 Query: 1248 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + GG + H D + I +I G A+ Q ++ D IL++ ++ +T +A +K Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297 Query: 1306 ALPDGPVTIVIRRKSLQSK 1324 V RRK + K Sbjct: 298 EAGSIVRLYVKRRKPVSEK 316 Score = 32.0 bits (71), Expect = 4.1 Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E++L++ +G+G I G P+ S IF+ + G A DGRLR D I+ +++ Sbjct: 224 EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283 Query: 413 VHCLT 417 V +T Sbjct: 284 VRDVT 288 >gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] Length = 926 Score = 80.1 bits (196), Expect = 1e-14 Identities = 70/246 (28%), Positives = 106/246 (43%), Gaps = 14/246 (5%) Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271 I I L+KG KGLGFSI GG I G IYV I GGAA DG+LQ GD++L +N Sbjct: 317 IMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVN 375 Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325 + +TH++A+ K K T APP + + S P+ +S S+ Sbjct: 376 NVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435 Query: 326 CITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVH 385 + + +S A SP + + GLG + + GIF+ Sbjct: 436 FLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVG---GEDGEGIFIS 492 Query: 386 TLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQV 445 + G A L G LR GD I+ ++ + + + L + G IV+++ + Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNA--GQAVTIVAQYRPEEY 550 Query: 446 SEQQLK 451 S + K Sbjct: 551 SRFEAK 556 Score = 71.6 bits (174), Expect = 5e-12 Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 35/216 (16%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ G A+Q+G ++ + +L +N ++ TH Sbjct: 232 SGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSK 291 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + + RK E + ++ L Sbjct: 292 AVEALKEAGSIVRLYVKRRKPVSEKIMEIK-----------------------------L 322 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD++L + ++ + Sbjct: 323 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEV 382 Query: 1296 TRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331 T EA +K D V + S+ + A D Sbjct: 383 THEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPD 418 Score = 63.9 bits (154), Expect = 1e-09 Identities = 61/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%) Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N Sbjct: 225 ITLERGNS-GLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 + +TH A++ K+A ++ L V+ R Sbjct: 284 VRDVTHSKAVEALKEA-GSIVRLYVKRR-------------------------------- 310 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 KP ++E+ L K GLG + Q I G I+V + G Sbjct: 311 ------------KPVSEKIMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427 AH DG+L+ GD+++ +++ + +T E T L + Sbjct: 358 AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKN 393 Score = 57.0 bits (136), Expect = 1e-07 Identities = 50/214 (23%), Positives = 96/214 (44%), Gaps = 39/214 (18%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ TH +A Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387 Query: 1179 LAILRQAREPRQAVIVTRKLTPEAM--------PDLNSSTD---------------SAAS 1215 + L+ + + + P +M PD+ +S+ + AS Sbjct: 388 VTALKNTSD----FVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPAS 443 Query: 1216 ASAASDVSVESTAEATVCT----VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAA 1271 + S VS + + V L + S GLGF++ GG+ + + I+ I G Sbjct: 444 PARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDG----EGIFISFILAGGP 499 Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 ++ S ++ GD I+ + ++ + +A +K Sbjct: 500 ADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533 Score = 49.7 bits (117), Expect = 2e-05 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 +LH+ GLGF++ GG D E I + + G A G ++KG+ ++S+N L+ + Sbjct: 468 VLHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDRIISVNSVDLRAAS 524 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A A L+ A QAV + + PE Sbjct: 525 HEQAAAALKNA---GQAVTIVAQYRPE 548 Score = 44.7 bits (104), Expect = 6e-04 Identities = 34/139 (24%), Positives = 63/139 (45%), Gaps = 6/139 (4%) Query: 1188 PRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFS 1247 P + ++ + P + +TDS + + + + E +TLE+ ++GLGFS Sbjct: 182 PAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEE----ITLERGNSGLGFS 237 Query: 1248 LEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + GG + H D + I +I G A+ Q ++ D IL++ ++ +T +A +K Sbjct: 238 IAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALK 297 Query: 1306 ALPDGPVTIVIRRKSLQSK 1324 V RRK + K Sbjct: 298 EAGSIVRLYVKRRKPVSEK 316 Score = 32.0 bits (71), Expect = 4.1 Identities = 21/65 (32%), Positives = 35/65 (53%), Gaps = 2/65 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E++L++ +G+G I G P+ S IF+ + G A DGRLR D I+ +++ Sbjct: 224 EITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVD 283 Query: 413 VHCLT 417 V +T Sbjct: 284 VRDVT 288 >gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] Length = 749 Score = 78.2 bits (191), Expect = 5e-14 Identities = 75/233 (32%), Positives = 101/233 (43%), Gaps = 41/233 (17%) Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271 + I L KG KGLGFSI GG I G IYV I GGAA DGRLQ GD +L +N Sbjct: 140 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 198 Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSST 325 S+ +TH++A+ K K G T T PP + SPP+ L S Sbjct: 199 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGN 258 Query: 326 CITKD-SSSFALESPS--API------------------STAKPNYRIMVEVSLQKE--- 361 T + +S SP +PI +T +P+ + VSL+ E Sbjct: 259 NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRK 318 Query: 362 -----AGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 GLG + + GIFV + G A L G L+ GD+I+ ++ Sbjct: 319 VVLHKGSTGLGFNIVG---GEDGEGIFVSFILAGGPADLSGELQRGDQILSVN 368 Score = 70.5 bits (171), Expect = 1e-11 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ P G A+++G ++ + +L +N + +H Sbjct: 55 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 114 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + R P L TV + L Sbjct: 115 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 145 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I G A+++ +Q GD +L + +++ + Sbjct: 146 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 205 Query: 1296 TRFEAWNIIK 1305 T EA I+K Sbjct: 206 THEEAVAILK 215 Score = 64.7 bits (156), Expect = 6e-10 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%) Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 I L +G + GLGFSI GG D+ I GI++ I GGAAA DGRL+ D IL +N Sbjct: 48 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 ++ ++H A++ K+A ++ L VR R Sbjct: 107 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 133 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 +P +VE+ L K GLG + Q I G I+V + G Sbjct: 134 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427 A DGRL+ GD ++ +++ + +T E IL + Sbjct: 181 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 216 Score = 63.5 bits (153), Expect = 1e-09 Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%) Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244 TS S +T Q PS LQ +V +VL KG GLGF+IVGG+D GI Sbjct: 290 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 341 Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290 +V I AGG A G LQ GD+IL +NG + G +H+ A K A Sbjct: 342 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 387 Score = 60.1 bits (144), Expect = 1e-08 Identities = 56/239 (23%), Positives = 98/239 (41%), Gaps = 60/239 (25%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+ +L +N SL+ TH +A Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210 Query: 1179 LAILRQARE----------------PRQAVIVTRKLTP-----------------EAMPD 1205 +AIL+ E P +T +P ++P Sbjct: 211 VAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPP 270 Query: 1206 L-------------------NSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGF 1246 + + S S A+ + + + E V L K S GLGF Sbjct: 271 ISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGF 330 Query: 1247 SLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 ++ GG+ + + ++ I G ++ S +Q GD+IL + G ++G + +A +K Sbjct: 331 NIVGGEDG----EGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385 Score = 54.7 bits (130), Expect = 6e-07 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 +LHK GLGF++ GG D E I V + G A G +Q+G+++LS+NG L+G + Sbjct: 320 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 376 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A A L+ A Q V + + PE Sbjct: 377 HEQAAAALKGA---GQTVTIIAQYQPE 400 Score = 38.9 bits (89), Expect = 0.033 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292 +TLE+ ++GLGFS+ GG + H GD P + I +I G A+ + ++ D IL++ + Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107 Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319 ++ +A +K V + +RR+ Sbjct: 108 SEVSHSKAVEALKE-AGSIVRLYVRRR 133 Score = 35.0 bits (79), Expect = 0.48 Identities = 24/81 (29%), Positives = 42/81 (51%), Gaps = 3/81 (3%) Query: 335 ALESPSAPISTAKPNYRIMVEVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSV 392 A++ P++ + Y E++L++ +G+G I G P+ GIF+ + PG Sbjct: 28 AMQHAFIPVNGTEIEYEFE-EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGA 86 Query: 393 AHLDGRLRCGDEIVEISDSPV 413 A DGRLR D I+ +++ V Sbjct: 87 AAEDGRLRVNDCILRVNEVDV 107 >gi|57529737 PDZ domain containing ring finger 3 [Homo sapiens] Length = 1066 Score = 77.4 bits (189), Expect = 8e-14 Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 38/277 (13%) Query: 205 PSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-----YGPIGIYVKTIFAGGAAAADG 259 P GG S +++ + LGF+I+GG+ S+ GI+V I G AA +G Sbjct: 237 PPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEG 296 Query: 260 RLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL----LTLTVRTRLTAPPSLCSHLSP 315 LQ D I+E+NG ++ TH A++ FK AK+ + L T RT++ PPS + Sbjct: 297 GLQIHDRIIEVNGRDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPPSESQLVDT 356 Query: 316 -----------PLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRI------------ 352 +SS + D E PSA PN I Sbjct: 357 GTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPSAH-EYYDPNDYIGDIHQEMDREEL 415 Query: 353 -MVEVSLQK-EAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISD 410 + EV L + + LG+ +C + GI++ + P S+A DGR+R GD I++I+ Sbjct: 416 ELEEVDLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING 475 Query: 411 SPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447 V E +L+ + ++++R P+ Q+ E Sbjct: 476 IEVQ--NREEAVALLTSEENKNFSLLIAR-PELQLDE 509 Score = 49.3 bits (116), Expect = 2e-05 Identities = 30/118 (25%), Positives = 57/118 (48%), Gaps = 10/118 (8%) Query: 1115 ILHKEEGAGLGFSLAGGADL-------ENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167 +LH++ G+ LGF++ GG ++ I V ++ +G A++EG +Q + ++ +NG Sbjct: 251 VLHRDSGS-LGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNG 309 Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225 + L TH A+ + A+EP V+ + TP S +D++ E Sbjct: 310 RDLSRATHDQAVEAFKTAKEP--IVVQVLRRTPRTKMFTPPSESQLVDTGTQTDITFE 365 Score = 35.4 bits (80), Expect = 0.37 Identities = 18/74 (24%), Positives = 42/74 (56%), Gaps = 3/74 (4%) Query: 1124 LGFSLAGGADLENKV-ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAIL 1182 LG ++ D E+ + I + + PN +A+++G I++G+ ++ ING ++ +A+A+L Sbjct: 431 LGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQING--IEVQNREEAVALL 488 Query: 1183 RQAREPRQAVIVTR 1196 ++++ R Sbjct: 489 TSEENKNFSLLIAR 502 Score = 34.3 bits (77), Expect = 0.82 Identities = 23/109 (21%), Positives = 51/109 (46%), Gaps = 6/109 (5%) Query: 1229 EATVCTVTLEKMSAGLGFSLEGGKGSL-----HGDKPLTINRIFKGAASEQSETVQPGDE 1283 E T+ L + S LGF++ GG+ S+ + + +++I + + +Q D Sbjct: 244 ETKSLTLVLHRDSGSLGFNIIGGRPSVDNHDGSSSEGIFVSKIVDSGPAAKEGGLQIHDR 303 Query: 1284 ILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332 I+++ G + T +A K + P+ + + R++ ++K T +S Sbjct: 304 IIEVNGRDLSRATHDQAVEAFKTAKE-PIVVQVLRRTPRTKMFTPPSES 351 >gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens] Length = 767 Score = 77.0 bits (188), Expect = 1e-13 Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 22/215 (10%) Query: 211 ASVISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEIL 268 A + I L+KG KGLGFSI GG I G IYV I GGAA DGRLQ GD+IL Sbjct: 198 AEKVMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256 Query: 269 ELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322 +N + + H+DA+ K K + + APP + + S L +S Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 316 Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKE--------AGVGLGIGLCSVP 374 S+ + D + +P++P + ++ E + +E GLG + Sbjct: 317 HSSYLGTDYPT--AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG-- 372 Query: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 + GIF+ + G A L G LR GD+I+ ++ Sbjct: 373 -GEDGEGIFISFILAGGPADLSGELRKGDQILSVN 406 Score = 71.6 bits (174), Expect = 5e-12 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ P G A+Q+G ++ + +L +N ++ TH Sbjct: 116 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 175 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + ++ RK E V + L Sbjct: 176 AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 206 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD+IL + ++ + Sbjct: 207 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 266 Query: 1296 TRFEAWNIIK 1305 +A +K Sbjct: 267 MHEDAVAALK 276 Score = 62.8 bits (151), Expect = 2e-09 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ H DA Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271 Query: 1179 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 1218 +A L+ + +P A + P+ + D+ S S+ Sbjct: 272 VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 331 Query: 1219 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269 A D+ E + + + S GLGF++ GG+ + + I+ I G Sbjct: 332 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 387 Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319 ++ S ++ GD+IL + G ++ + +A +K VTI+ + K Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 436 Score = 60.8 bits (146), Expect = 8e-09 Identities = 71/259 (27%), Positives = 105/259 (40%), Gaps = 64/259 (24%) Query: 168 SLCSNRKSLSQQLDCPAGKAAGTSRPTRS------LSTAQLVQPSGGLQAS------VIS 215 SL ++K Q D P + + P ++ ++T L P LQ + Sbjct: 48 SLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYE 107 Query: 216 NIVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273 I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N Sbjct: 108 EITLERGNS-GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166 Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333 + +TH A++ K+A ++ L V R Sbjct: 167 DVREVTHSAAVEALKEA-GSIVRLYVMRR------------------------------- 194 Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPG 390 KP ++E+ L K GLG + Q I G I+V + G Sbjct: 195 -------------KPPAEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 240 Query: 391 SVAHLDGRLRCGDEIVEIS 409 AH DGRL+ GD+I+ ++ Sbjct: 241 GAAHKDGRLQIGDKILAVN 259 Score = 56.2 bits (134), Expect = 2e-07 Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 5/74 (6%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 IV+ +G GLGF+IVGG+D GI++ I AGG A G L++GD+IL +NG + Sbjct: 357 IVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411 Query: 277 GLTHQDALQKFKQA 290 +H+ A K A Sbjct: 412 NASHEQAAIALKNA 425 Score = 48.9 bits (115), Expect = 3e-05 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 ++H+ GLGF++ GG D E I + + G A G ++KG+++LS+NG L+ + Sbjct: 358 VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 414 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A L+ A Q V + + PE Sbjct: 415 HEQAAIALKNA---GQTVTIIAQYKPE 438 Score = 42.7 bits (99), Expect = 0.002 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292 +TLE+ ++GLGFS+ GG + H GD P + I +I G A+ Q ++ D IL + + Sbjct: 109 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168 Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319 + +T A +K V+RRK Sbjct: 169 REVTHSAAVEALKEAGSIVRLYVMRRK 195 Score = 33.9 bits (76), Expect = 1.1 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E++L++ +G+G I G P+ IF+ + PG A DGRLR D I+ +++ Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167 Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451 V +T + L V + V R P ++K Sbjct: 168 VREVTHSAAVEALKEAG-SIVRLYVMRRKPPAEKVMEIK 205 >gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sapiens] Length = 721 Score = 77.0 bits (188), Expect = 1e-13 Identities = 66/215 (30%), Positives = 98/215 (45%), Gaps = 22/215 (10%) Query: 211 ASVISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEIL 268 A + I L+KG KGLGFSI GG I G IYV I GGAA DGRLQ GD+IL Sbjct: 152 AEKVMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210 Query: 269 ELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322 +N + + H+DA+ K K + + APP + + S L +S Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEIS 270 Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKE--------AGVGLGIGLCSVP 374 S+ + D + +P++P + ++ E + +E GLG + Sbjct: 271 HSSYLGTDYPT--AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG-- 326 Query: 375 YFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 + GIF+ + G A L G LR GD+I+ ++ Sbjct: 327 -GEDGEGIFISFILAGGPADLSGELRKGDQILSVN 360 Score = 71.6 bits (174), Expect = 5e-12 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 35/190 (18%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ P G A+Q+G ++ + +L +N ++ TH Sbjct: 70 SGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSA 129 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + ++ RK E V + L Sbjct: 130 AVEALKEAGSIVRLYVMRRKPPAE-----------------------------KVMEIKL 160 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I +G A+ + +Q GD+IL + ++ + Sbjct: 161 IKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDV 220 Query: 1296 TRFEAWNIIK 1305 +A +K Sbjct: 221 MHEDAVAALK 230 Score = 62.8 bits (151), Expect = 2e-09 Identities = 54/230 (23%), Positives = 100/230 (43%), Gaps = 38/230 (16%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+++L++N L+ H DA Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225 Query: 1179 LAILR--------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASA------------ 1218 +A L+ + +P A + P+ + D+ S S+ Sbjct: 226 VAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTP 285 Query: 1219 ---------ASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269 A D+ E + + + S GLGF++ GG+ + + I+ I G Sbjct: 286 TSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDG----EGIFISFILAG 341 Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319 ++ S ++ GD+IL + G ++ + +A +K VTI+ + K Sbjct: 342 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ-TVTIIAQYK 390 Score = 60.5 bits (145), Expect = 1e-08 Identities = 59/198 (29%), Positives = 84/198 (42%), Gaps = 52/198 (26%) Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 I L +G + GLGFSI GG D+ I I++ I GGAAA DGRL+ D IL +N Sbjct: 63 ITLERGNS-GLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 + +TH A++ K+A ++ L V R Sbjct: 122 VREVTHSAAVEALKEA-GSIVRLYVMRR-------------------------------- 148 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 KP ++E+ L K GLG + Q I G I+V + G Sbjct: 149 ------------KPPAEKVMEIKLIK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGG 195 Query: 392 VAHLDGRLRCGDEIVEIS 409 AH DGRL+ GD+I+ ++ Sbjct: 196 AAHKDGRLQIGDKILAVN 213 Score = 56.2 bits (134), Expect = 2e-07 Identities = 31/74 (41%), Positives = 44/74 (59%), Gaps = 5/74 (6%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 IV+ +G GLGF+IVGG+D GI++ I AGG A G L++GD+IL +NG + Sbjct: 311 IVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365 Query: 277 GLTHQDALQKFKQA 290 +H+ A K A Sbjct: 366 NASHEQAAIALKNA 379 Score = 48.9 bits (115), Expect = 3e-05 Identities = 28/87 (32%), Positives = 46/87 (52%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 ++H+ GLGF++ GG D E I + + G A G ++KG+++LS+NG L+ + Sbjct: 312 VIHRGS-TGLGFNIVGGEDGEG--IFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A L+ A Q V + + PE Sbjct: 369 HEQAAIALKNA---GQTVTIIAQYKPE 392 Score = 42.7 bits (99), Expect = 0.002 Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 2/87 (2%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292 +TLE+ ++GLGFS+ GG + H GD P + I +I G A+ Q ++ D IL + + Sbjct: 63 ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122 Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319 + +T A +K V+RRK Sbjct: 123 REVTHSAAVEALKEAGSIVRLYVMRRK 149 Score = 33.9 bits (76), Expect = 1.1 Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E++L++ +G+G I G P+ IF+ + PG A DGRLR D I+ +++ Sbjct: 62 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 121 Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLK 451 V +T + L V + V R P ++K Sbjct: 122 VREVTHSAAVEALKEAG-SIVRLYVMRRKPPAEKVMEIK 159 >gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] Length = 1356 Score = 76.3 bits (186), Expect = 2e-13 Identities = 71/235 (30%), Positives = 105/235 (44%), Gaps = 23/235 (9%) Query: 183 PAGK--AAGTSRPTRSLSTAQLVQPSGGLQASVIS---NIVLMKGQAKGLGFSIVGGKDS 237 P+GK +A S P ST S G I NI L KG +GLGFSI + Sbjct: 427 PSGKPPSAPASAPQNVFSTTV----SSGYNTKKIGKRLNIQLKKG-TEGLGFSITSRDVT 481 Query: 238 IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAK-KGLLT 296 I G IYVK I GAA DGRL+ GD ++E+NG + G + ++ + + K +G ++ Sbjct: 482 IGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVS 541 Query: 297 LTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEV 356 L V + A P + S I K++ + + P T + + EV Sbjct: 542 LLVFRQEDA-------FHPRELNAEPSQMQIPKETKAEDEDIVLTPDGTRE---FLTFEV 591 Query: 357 SLQKEAGVGLGIGLCS--VPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 L GLG+ + GIFV ++ G A DGRLR D+++ ++ Sbjct: 592 PLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVN 646 Score = 70.9 bits (172), Expect = 8e-12 Identities = 41/122 (33%), Positives = 70/122 (57%), Gaps = 7/122 (5%) Query: 202 LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSI-YGPIGIYVKTIFAGGAAAADGR 260 +V G + + + L + GLG S+ G + + +GI+VK+I GGAA+ DGR Sbjct: 576 IVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGR 635 Query: 261 LQEGDEILELNGESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLS 314 L+ D+++ +NGES+ G T+QDA++ +++ K+G++ L V R++ L S S Sbjct: 636 LRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGS 695 Query: 315 PP 316 PP Sbjct: 696 PP 697 Score = 66.2 bits (160), Expect = 2e-10 Identities = 57/242 (23%), Positives = 110/242 (45%), Gaps = 25/242 (10%) Query: 1110 GIHVTILHKEEGAGLGFSLA------GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163 G + I K+ GLGFS+ GG+ I V + P G A Q+G ++ G+ ++ Sbjct: 457 GKRLNIQLKKGTEGLGFSITSRDVTIGGS----APIYVKNILPRGAAIQDGRLKAGDRLI 512 Query: 1164 SINGKSLKGTTHHDALAILRQAR-EPRQAVIVTRKLTPEAMPDLNS--STDSAASASAAS 1220 +NG L G + + +++LR + E +++V R+ +LN+ S + A Sbjct: 513 EVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKAE 572 Query: 1221 DVSVESTAEATVCTVTLE-----KMSAGLGFSLEGGKG-SLHGDKPLTINRIFKGAASEQ 1274 D + T + T +T E SAGLG S++G + H D + + I G A+ + Sbjct: 573 DEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASK 632 Query: 1275 SETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPD------GPVTIVIRRKSLQSKETTA 1328 ++ D+++ + G ++ G T +A ++ G + +++ R+ + E + Sbjct: 633 DGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692 Query: 1329 AG 1330 G Sbjct: 693 PG 694 Score = 49.3 bits (116), Expect = 2e-05 Identities = 31/99 (31%), Positives = 52/99 (52%), Gaps = 8/99 (8%) Query: 1095 EEVKVLDEATLKQLDGIHVTI-----LHKEEGAGLGFSLAGGADLENKV---ITVHRVFP 1146 +E K DE + DG + L+ AGLG S+ G EN I V + Sbjct: 567 KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIIN 626 Query: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185 G AS++G ++ ++++++NG+SL G T+ DA+ LR++ Sbjct: 627 GGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665 Score = 38.5 bits (88), Expect = 0.043 Identities = 61/272 (22%), Positives = 101/272 (37%), Gaps = 71/272 (26%) Query: 229 FSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFK 288 FS GG+ +G+ VK + GG A + +E D I+ +N + + A F+ Sbjct: 291 FSARGGRT-----LGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFR 345 Query: 289 QAKK------------------------------------------------GLLTLTVR 300 QA + GL T+ Sbjct: 346 QAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRA 405 Query: 301 TRLTAPP------SLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMV 354 RL PP S H + P + S+ ++ S + S+ +T K R+ + Sbjct: 406 PRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTV---SSGYNTKKIGKRLNI 462 Query: 355 EVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVAHLDGRLRCGDEIVEISDS 411 ++ K+ GLG + S I G I+V + P A DGRL+ GD ++E++ Sbjct: 463 QL---KKGTEGLGFSITSRDV--TIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGV 517 Query: 412 PVHCLTLNEVYTIL-SHCDPGPVPIIVSRHPD 442 + + EV ++L S G V ++V R D Sbjct: 518 DLVGKSQEEVVSLLRSTKMEGTVSLLVFRQED 549 >gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens] Length = 1076 Score = 75.5 bits (184), Expect = 3e-13 Identities = 84/322 (26%), Positives = 140/322 (43%), Gaps = 46/322 (14%) Query: 1006 PSSISCAQTPCIPKE--GASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTE 1063 P + IP+E G++ ++ G + +D +S LR+ G Sbjct: 33 PDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQ---GGIA 89 Query: 1064 AKED--DDGDHSSLQSG--------QSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHV 1113 A+ D D GD+ +G +ISLL + + ++E L +++ I Sbjct: 90 ARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFR 149 Query: 1114 TI---LHKEEGAGLGFSLAGGA-DLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSING 1167 T+ LHKE G GF + GGA D NK + + V P G A +EGTI+ G+ +LS++G Sbjct: 150 TVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDG 208 Query: 1168 KSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVEST 1227 L GTTH +A++IL+Q + A+++ + S DS A+AS V V T Sbjct: 209 IRLLGTTHAEAMSILKQCGQ-EAALLIEYDV---------SVMDSVATASGPLLVEVAKT 258 Query: 1228 AEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQL 1287 A++ M + + I++I + +++ + GD IL + Sbjct: 259 PGASLGVALTTSMCC--------------NKQVIVIDKIKSASIADRCGALHVGDHILSI 304 Query: 1288 GGTAMQGLTRFEAWNIIKALPD 1309 GT+M+ T EA + D Sbjct: 305 DGTSMEYCTLAEATQFLANTTD 326 Score = 70.5 bits (171), Expect = 1e-11 Identities = 59/230 (25%), Positives = 103/230 (44%), Gaps = 31/230 (13%) Query: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165 ++ G V L K+EG LG +++GG D + K V + G+A++ + G+ + ++ Sbjct: 46 EEFKGSTVVELMKKEGTTLGLTVSGGIDKDGKP-RVSNLRQGGIAARSDQLDVGDYIKAV 104 Query: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225 NG +L H + +++L+ E R + V +L P VSV+ Sbjct: 105 NGINLAKFRHDEIISLLKNVGE-RVVLEVEYELPP---------------------VSVQ 142 Query: 1226 -STAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDK----PLTINRIFKGAASEQSETVQP 1280 S+ VTL K GF + GG H D+ P+ I + G +++ T++P Sbjct: 143 GSSVIFRTVEVTLHKEGNTFGFVIRGGA---HDDRNKSRPVVITCVRPGGPADREGTIKP 199 Query: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330 GD +L + G + G T EA +I+K ++ S+ TA+G Sbjct: 200 GDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASG 249 Score = 50.1 bits (118), Expect = 1e-05 Identities = 49/244 (20%), Positives = 111/244 (45%), Gaps = 37/244 (15%) Query: 1088 EELKKLIEEVKVLDEATLK----------QLDGIHVTILHKEEGAGLGFSLAGGADLE-N 1136 EE +L+ + + + TL+ G L K+ LG +++ + + Sbjct: 486 EEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPG 545 Query: 1137 KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTR 1196 + + + +A + GT++ G+++L+I+ L + DA+ IL+Q + +V Sbjct: 546 DPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-----LVKL 600 Query: 1197 KLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLH 1256 K+ D ++S + +S A + TV L++ LG ++ G + Sbjct: 601 KIRK----DEDNSDEQESSG-------------AIIYTVELKRYGGPLGITISGTEEPFD 643 Query: 1257 GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316 P+ I+ + KG +E++ + GD IL + ++++G EA ++++ + VT+ I Sbjct: 644 ---PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQ-MAGETVTLKI 699 Query: 1317 RRKS 1320 ++++ Sbjct: 700 KKQT 703 Score = 48.1 bits (113), Expect = 5e-05 Identities = 69/322 (21%), Positives = 120/322 (37%), Gaps = 54/322 (16%) Query: 154 MTKKSAAPTDRQPYSLCS-NRKSLSQQLDCPAGKAAGTSRPTRSL---STAQLVQPSGGL 209 + S +PT YSL S N +L + L + + R + S+ L + GL Sbjct: 350 LVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGL 409 Query: 210 QASVI----SNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFAGGAAAADGRLQ 262 V+ + +VL G G + G +++ P + I A A G LQ Sbjct: 410 AGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPP--LISYIEADSPAERCGVLQ 467 Query: 263 EGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322 GD ++ +NG T ++A Q + + ++T + L + + P S Sbjct: 468 IGDRVMAINGIPTEDSTFEEASQLLRDS-----SITSKVTLEIEFDVAESVIP------S 516 Query: 323 SSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGI 382 S T V L K+ V LGI + S + + Sbjct: 517 SGT----------------------------FHVKLPKKHNVELGITISSPSSRKPGDPL 548 Query: 383 FVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD 442 + + GSVAH G L GD+++ I + + ++ + IL C+ + + R + Sbjct: 549 VISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCE--DLVKLKIRKDE 606 Query: 443 PQVSEQQLKEAVAQAVENTKFG 464 EQ+ A+ VE ++G Sbjct: 607 DNSDEQESSGAIIYTVELKRYG 628 Score = 46.2 bits (108), Expect = 2e-04 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 24/181 (13%) Query: 1150 ASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSS 1209 A + G +Q G+ V++ING + +T +A +LR + +T K+T E D+ Sbjct: 460 AERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSS-------ITSKVTLEIEFDV--- 509 Query: 1210 TDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKG 1269 +S +S V + +K + LG ++ GD PL I+ I KG Sbjct: 510 AESVIPSSGTFHVKLP------------KKHNVELGITISSPSSRKPGD-PLVISDIKKG 556 Query: 1270 AASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAA 1329 + + ++ T++ GD++L + + + +A I++ D V + IR+ S E ++ Sbjct: 557 SVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCED-LVKLKIRKDEDNSDEQESS 615 Query: 1330 G 1330 G Sbjct: 616 G 616 Score = 42.7 bits (99), Expect = 0.002 Identities = 42/153 (27%), Positives = 73/153 (47%), Gaps = 10/153 (6%) Query: 1071 DHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG-IHVTILHKEEGAGLGFSLA 1129 D+ S++ ++ E+L KL + K D + ++ G I T+ K G LG +++ Sbjct: 580 DNCSMEDAVQILQ--QCEDLVKL-KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITIS 636 Query: 1130 GGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPR 1189 G + + +I + + GLA + G I G+ +L+IN SLKG +A+ +L+ A E Sbjct: 637 GTEEPFDPII-ISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGE-- 693 Query: 1190 QAVIVTRKLTPEAMPDLNSSTDSAASASAASDV 1222 VT K+ + SS +S SD+ Sbjct: 694 ---TVTLKIKKQTDAQSASSPKKFPISSHLSDL 723 Score = 41.6 bits (96), Expect = 0.005 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 5/148 (3%) Query: 1088 EELKKLIE-EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFP 1146 +E LIE +V V+D ++ G + + K GA LG +L +VI + ++ Sbjct: 228 QEAALLIEYDVSVMD--SVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKS 285 Query: 1147 NGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAM--P 1204 +A + G + G+ +LSI+G S++ T +A L + + I+ T A+ P Sbjct: 286 ASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGP 345 Query: 1205 DLNSSTDSAASASAASDVSVESTAEATV 1232 D + S+ S ++ S S+ S T+ Sbjct: 346 DHAALVSSSFSPTSMSAYSLSSLNMGTL 373 Score = 37.7 bits (86), Expect = 0.074 Identities = 56/243 (23%), Positives = 93/243 (38%), Gaps = 44/243 (18%) Query: 187 AAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYV 246 A+ T P +L+ + P ++V+ LMK + LG ++ GG D P V Sbjct: 27 ASQTKPPDGALAVRRQSIPEEFKGSTVVE---LMKKEGTTLGLTVSGGIDKDGKP---RV 80 Query: 247 KTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAP 306 + GG AA +L GD I +NG ++A H + + K + ++ L V L Sbjct: 81 SNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV-LEVEYEL--- 136 Query: 307 PSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGV-G 365 PP+ S+ S+ I + VEV+L KE G Sbjct: 137 --------PPV--SVQGSSVIFR-----------------------TVEVTLHKEGNTFG 163 Query: 366 LGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTIL 425 I + + + + PG A +G ++ GD ++ + + T E +IL Sbjct: 164 FVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSIL 223 Query: 426 SHC 428 C Sbjct: 224 KQC 226 Score = 35.4 bits (80), Expect = 0.37 Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 5/115 (4%) Query: 218 VLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAG 277 V +K LG +I G ++ + PI + ++ GG A G + GD IL +N S+ G Sbjct: 622 VELKRYGGPLGITISGTEEP-FDPI--IISSLTKGGLAERTGAIHIGDRILAINSSSLKG 678 Query: 278 LTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332 +A+ + A + +TL ++ + T S S P+ LS + +DSS Sbjct: 679 KPLSEAIHLLQMAGE-TVTLKIK-KQTDAQSASSPKKFPISSHLSDLGDVEEDSS 731 >gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sapiens] Length = 1287 Score = 74.7 bits (182), Expect = 5e-13 Identities = 78/309 (25%), Positives = 128/309 (41%), Gaps = 21/309 (6%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LGFS+ GG ++ GIYVK+I GG AA +G++ +GD +L+++G + GLTH+ A+Q Sbjct: 938 LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 997 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + + L + R+ S C S + S + + S P P S Sbjct: 998 LTGPGQ-VARLVLERRVPR--------STQQCPSANDSMGDERTAVSLVTALPGRPSSCV 1048 Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----ISGIFVHTLSPGSVAHLDGRLRCG 402 EV L+K A GLG + C + + L PG A +G + G Sbjct: 1049 SVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAG 1107 Query: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTK 462 D I+ ++ L EV +L P V +++ R P + E + + + + + Sbjct: 1108 DIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCRPPPGALPELEQEWQTPELSADKE 1166 Query: 463 FGKERHQWSLEG-VKRLESSWHGRPTLEKE-----REKNSAPPHRRAQKVMIRSSSDSSY 516 F + S + E SW + + R ++S R AQ R +S Sbjct: 1167 FTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASS 1226 Query: 517 MSGSPGGSP 525 ++ SP P Sbjct: 1227 LTHSPESHP 1235 Score = 72.4 bits (176), Expect = 3e-12 Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%) Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 I+ L KE+G LGFS+ GG + I V + P G A++EG I +G+ +L ++G Sbjct: 926 IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 984 Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 1222 L G TH A+ L + + V+ R P + S+ DS A + Sbjct: 985 ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1042 Query: 1223 ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 1276 S S + V L+K + GLGFS +E S + I R+F G +E++ Sbjct: 1043 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1102 Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 + GD IL + G + +GL E ++++ P VT+++ R Sbjct: 1103 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1143 Score = 52.4 bits (124), Expect = 3e-06 Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%) Query: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163 DG + K+ GLGFS + L++ ++ + R+FP A + G I G+ +L Sbjct: 1052 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1111 Query: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206 ++NG+S +G + L +LR A P++ ++ + P A+P+L Sbjct: 1112 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1152 Score = 48.1 bits (113), Expect = 5e-05 Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 55/300 (18%) Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273 I + L + +G GF I G+ S GI++ +I GG A ++ G +IL LN Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810 Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI------ 327 S+ G T A++ + + + + +++ + + +SS+ + Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQG 870 Query: 328 -----TKDSSSFALESPSAPISTAKPNYRIMVE-------------------------VS 357 T+D E A + + P R + V Sbjct: 871 SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 930 Query: 358 LQKEAGVGLGIGL-----CSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 L KE G LG + SVPY GI+V ++ PG A +G++ GD ++++ Sbjct: 931 LVKEDGT-LGFSVTGGINTSVPY----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVI 985 Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSL 472 + LT + L+ PG V +V P+ S QQ A N G ER SL Sbjct: 986 LCGLTHKQAVQCLT--GPGQVARLVLERRVPR-STQQCPSA------NDSMGDERTAVSL 1036 Score = 45.1 bits (105), Expect = 5e-04 Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%) Query: 1232 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 1290 + VTL++ G GF + G+ S D + I+ I G +E+++T++PG +IL L Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810 Query: 1291 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 1321 +++G T A +I+ PD I+ + K + Sbjct: 811 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 841 Score = 45.1 bits (105), Expect = 5e-04 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%) Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 L ++ G GF + G + + I + + P G A + TI+ G ++L++N SL+G Sbjct: 756 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 815 Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 1216 T + A+ +++ + + + +I K PD SSTD S S Sbjct: 816 TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 875 Query: 1217 SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 1243 + D + E A V C + ++SAG Sbjct: 876 TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 935 Query: 1244 --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301 LGFS+ GG + + + I G + + + GD +LQ+ G + GLT +A Sbjct: 936 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995 Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332 + ++ RR +++ +A DS Sbjct: 996 QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1026 Score = 30.8 bits (68), Expect = 9.1 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 2/90 (2%) Query: 351 RIMVEVSLQKEAGVGLGIGLCSVPYF-QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 R +V V+L+++ G G + Y Q GIF+ ++ PG A ++ G +I+ ++ Sbjct: 749 REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 808 Query: 410 DSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439 + T N ++ + P + +I+S+ Sbjct: 809 HISLEGFTFNMAVRMIQN-SPDNIELIISQ 837 >gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sapiens] Length = 1309 Score = 74.7 bits (182), Expect = 5e-13 Identities = 78/309 (25%), Positives = 128/309 (41%), Gaps = 21/309 (6%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LGFS+ GG ++ GIYVK+I GG AA +G++ +GD +L+++G + GLTH+ A+Q Sbjct: 960 LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQC 1019 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + + L + R+ S C S + S + + S P P S Sbjct: 1020 LTGPGQ-VARLVLERRVPR--------STQQCPSANDSMGDERTAVSLVTALPGRPSSCV 1070 Query: 347 KPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQC----ISGIFVHTLSPGSVAHLDGRLRCG 402 EV L+K A GLG + C + + L PG A +G + G Sbjct: 1071 SVTDGPKFEVKLKKNAN-GLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAG 1129 Query: 403 DEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTK 462 D I+ ++ L EV +L P V +++ R P + E + + + + + Sbjct: 1130 DIILAVNGRSTEGLIFQEVLHLLRGA-PQEVTLLLCRPPPGALPELEQEWQTPELSADKE 1188 Query: 463 FGKERHQWSLEG-VKRLESSWHGRPTLEKE-----REKNSAPPHRRAQKVMIRSSSDSSY 516 F + S + E SW + + R ++S R AQ R +S Sbjct: 1189 FTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASS 1248 Query: 517 MSGSPGGSP 525 ++ SP P Sbjct: 1249 LTHSPESHP 1257 Score = 72.4 bits (176), Expect = 3e-12 Identities = 64/222 (28%), Positives = 103/222 (46%), Gaps = 18/222 (8%) Query: 1111 IHVTILHKEEGAGLGFSLAGGADLENKV--ITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 I+ L KE+G LGFS+ GG + I V + P G A++EG I +G+ +L ++G Sbjct: 948 IYFVELVKEDGT-LGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGV 1006 Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDV------ 1222 L G TH A+ L + + V+ R P + S+ DS A + Sbjct: 1007 ILCGLTHKQAVQCLTGPGQVARLVLERR--VPRSTQQCPSANDSMGDERTAVSLVTALPG 1064 Query: 1223 ---SVESTAEATVCTVTLEKMSAGLGFS---LEGGKGSLHGDKPLTINRIFKGAASEQSE 1276 S S + V L+K + GLGFS +E S + I R+F G +E++ Sbjct: 1065 RPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENG 1124 Query: 1277 TVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRR 1318 + GD IL + G + +GL E ++++ P VT+++ R Sbjct: 1125 AIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQ-EVTLLLCR 1165 Score = 52.4 bits (124), Expect = 3e-06 Identities = 30/103 (29%), Positives = 55/103 (53%), Gaps = 7/103 (6%) Query: 1109 DGIHVTILHKEEGAGLGFSLA-----GGADLENKVITVHRVFPNGLASQEGTIQKGNEVL 1163 DG + K+ GLGFS + L++ ++ + R+FP A + G I G+ +L Sbjct: 1074 DGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIIL 1133 Query: 1164 SINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDL 1206 ++NG+S +G + L +LR A P++ ++ + P A+P+L Sbjct: 1134 AVNGRSTEGLIFQEVLHLLRGA--PQEVTLLLCRPPPGALPEL 1174 Score = 48.1 bits (113), Expect = 5e-05 Identities = 69/300 (23%), Positives = 114/300 (38%), Gaps = 55/300 (18%) Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273 I + L + +G GF I G+ S GI++ +I GG A ++ G +IL LN Sbjct: 773 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832 Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCI------ 327 S+ G T A++ + + + + +++ + + +SS+ + Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQG 892 Query: 328 -----TKDSSSFALESPSAPISTAKPNYRIMVE-------------------------VS 357 T+D E A + + P R + V Sbjct: 893 SLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVE 952 Query: 358 LQKEAGVGLGIGL-----CSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 L KE G LG + SVPY GI+V ++ PG A +G++ GD ++++ Sbjct: 953 LVKEDGT-LGFSVTGGINTSVPY----GGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVI 1007 Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSL 472 + LT + L+ PG V +V P+ S QQ A N G ER SL Sbjct: 1008 LCGLTHKQAVQCLT--GPGQVARLVLERRVPR-STQQCPSA------NDSMGDERTAVSL 1058 Score = 45.1 bits (105), Expect = 5e-04 Identities = 27/91 (29%), Positives = 49/91 (53%), Gaps = 1/91 (1%) Query: 1232 VCTVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGT 1290 + VTL++ G GF + G+ S D + I+ I G +E+++T++PG +IL L Sbjct: 773 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 832 Query: 1291 AMQGLTRFEAWNIIKALPDGPVTIVIRRKSL 1321 +++G T A +I+ PD I+ + K + Sbjct: 833 SLEGFTFNMAVRMIQNSPDNIELIISQSKGV 863 Score = 45.1 bits (105), Expect = 5e-04 Identities = 59/271 (21%), Positives = 105/271 (38%), Gaps = 54/271 (19%) Query: 1116 LHKEEGAGLGFSLAGG--ADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 L ++ G GF + G + + I + + P G A + TI+ G ++L++N SL+G Sbjct: 778 LKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGF 837 Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPDLN---------SSTD--------SAASA 1216 T + A+ +++ + + + +I K PD SSTD S S Sbjct: 838 TFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSH 897 Query: 1217 SAASDVSVESTAEATV----------------------CTVTLEKMSAG----------- 1243 + D + E A V C + ++SAG Sbjct: 898 TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKED 957 Query: 1244 --LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAW 1301 LGFS+ GG + + + I G + + + GD +LQ+ G + GLT +A Sbjct: 958 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 1017 Query: 1302 NIIKALPDGPVTIVIRRKSLQSKETTAAGDS 1332 + ++ RR +++ +A DS Sbjct: 1018 QCLTGPGQVARLVLERRVPRSTQQCPSANDS 1048 Score = 30.8 bits (68), Expect = 9.1 Identities = 21/90 (23%), Positives = 44/90 (48%), Gaps = 2/90 (2%) Query: 351 RIMVEVSLQKEAGVGLGIGLCSVPYF-QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 R +V V+L+++ G G + Y Q GIF+ ++ PG A ++ G +I+ ++ Sbjct: 771 REIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALN 830 Query: 410 DSPVHCLTLNEVYTILSHCDPGPVPIIVSR 439 + T N ++ + P + +I+S+ Sbjct: 831 HISLEGFTFNMAVRMIQN-SPDNIELIISQ 859 >gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens] Length = 817 Score = 73.9 bits (180), Expect = 9e-13 Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 35/223 (15%) Query: 1115 ILHKEEGAGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSL 1170 I+ + +GLGFS+AGG D ++ I + ++ P G A+ +G + + VL +N + Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191 Query: 1171 KGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEA 1230 H A+ L++A + V+ R+ PE Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRRRQPPPE----------------------------- 222 Query: 1231 TVCTVTLEKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLG 1288 T+ V L K GLGFS+ GG G+ H GD + I +I +G A+++ +Q GD +L + Sbjct: 223 TIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282 Query: 1289 GTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGD 1331 T +Q + EA +K D V + SL + A D Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPD 325 Score = 71.6 bits (174), Expect = 5e-12 Identities = 68/221 (30%), Positives = 96/221 (43%), Gaps = 33/221 (14%) Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271 I + L+KG KGLGFSI GG I G IY+ I GGAA DGRLQ GD +L +N Sbjct: 224 IMEVNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVN 282 Query: 272 GESMAGLTHQDALQKFKQ---------AKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLS 322 ++ + H++A+ K AK G L L + APP S + +S Sbjct: 283 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHL---NDMYAPPDYASTFTALADNHIS 339 Query: 323 SSTCI----TKDSSSFALESPSAPISTAKPNYRIMV----------EVSLQKEAGVGLGI 368 ++ + +S P P + P R M+ ++ L K GLG Sbjct: 340 HNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHK-GSTGLGF 398 Query: 369 GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 + + GIFV + G A L G LR GD I+ ++ Sbjct: 399 NIVG---GEDGEGIFVSFILAGGPADLSGELRRGDRILSVN 436 Score = 60.8 bits (146), Expect = 8e-09 Identities = 57/200 (28%), Positives = 88/200 (44%), Gaps = 52/200 (26%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPI--GIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 IVL +G + GLGFSI GG D+ + P GI++ I GGAAA DGRL D +L +N Sbjct: 132 IVLERGNS-GLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 ++ + H A++ K+A ++ L VR R P ++ Sbjct: 191 VSEVVHSRAVEALKEAGP-VVRLVVRRRQPPPETI------------------------- 224 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 +EV+L K GLG + Q I G I++ + G Sbjct: 225 -------------------MEVNLLK-GPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGG 264 Query: 392 VAHLDGRLRCGDEIVEISDS 411 A DGRL+ GD ++ ++++ Sbjct: 265 AAQKDGRLQIGDRLLAVNNT 284 Score = 60.1 bits (144), Expect = 1e-08 Identities = 34/74 (45%), Positives = 44/74 (59%), Gaps = 5/74 (6%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I+L KG GLGF+IVGG+D GI+V I AGG A G L+ GD IL +NG ++ Sbjct: 387 IILHKGST-GLGFNIVGGEDGE----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441 Query: 277 GLTHQDALQKFKQA 290 TH+ A K+A Sbjct: 442 NATHEQAAAALKRA 455 Score = 54.7 bits (130), Expect = 6e-07 Identities = 53/235 (22%), Positives = 99/235 (42%), Gaps = 49/235 (20%) Query: 1123 GLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG + + I + ++ G A ++G +Q G+ +L++N +L+ H +A Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294 Query: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE--------STAEA 1230 +A L+ + + K + D+ + D A++ +A +D + E+ Sbjct: 295 VASLKNTSD--MVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVES 352 Query: 1231 TVC------------------------------TVTLEKMSAGLGFSLEGGKGSLHGDKP 1260 V + L K S GLGF++ GG+ + Sbjct: 353 KVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG----EG 408 Query: 1261 LTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIV 1315 + ++ I G ++ S ++ GD IL + G ++ T +A +K VTIV Sbjct: 409 IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQS-VTIV 462 Score = 54.7 bits (130), Expect = 6e-07 Identities = 33/87 (37%), Positives = 49/87 (56%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 ILHK GLGF++ GG D E I V + G A G +++G+ +LS+NG +L+ T Sbjct: 388 ILHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNAT 444 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A A L++A Q+V + + PE Sbjct: 445 HEQAAAALKRA---GQSVTIVAQYRPE 468 Score = 36.2 bits (82), Expect = 0.22 Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 2/92 (2%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E+ L++ +G+G I G P+ GIF+ + PG A +DGRL D ++ +++ Sbjct: 131 EIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVD 190 Query: 413 VHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQ 444 V + + L P ++ R P P+ Sbjct: 191 VSEVVHSRAVEALKEAGPVVRLVVRRRQPPPE 222 >gi|18375648 protein tyrosine phosphatase, non-receptor type 13 isoform 3 [Homo sapiens] Length = 2294 Score = 73.9 bits (180), Expect = 9e-13 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%) Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110 +S++ +Y++ + D+ +SS Q Q+ SS K + K D Sbjct: 1118 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1175 Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 V + + LG S+ GG + + + I V V P G A +G I KG+ VL++NG Sbjct: 1176 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233 Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215 SL+G TH A+ LR Q+ ++ V VT + T + D N+ Sbjct: 1234 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1290 Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271 + V S E V L K S+GLGFS + + + ++F G Sbjct: 1291 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1350 Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + +S + GD IL++ G +++GL++ E + ++ Sbjct: 1351 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1384 Score = 71.6 bits (174), Expect = 5e-12 Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ A++ Sbjct: 1187 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1246 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + + V L S S P+ + C D ++ +T Sbjct: 1247 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1296 Query: 347 KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397 +Y + EV L K + GLG +P S + V L PG A G Sbjct: 1297 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1355 Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452 ++ GD I++++ + + L+ EV + L P V +++ R P P++ L + Sbjct: 1356 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1414 Query: 453 AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512 + AQ + N+ K+ Q S V++ SS + + +K P RR S Sbjct: 1415 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1468 Query: 513 DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569 + ++ S + S+ + S+ V + P ++E + ++ PQ+ P Sbjct: 1469 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1526 Query: 570 PESRDSHP 577 PE DS+P Sbjct: 1527 PEFEDSNP 1534 Score = 58.2 bits (139), Expect = 5e-08 Identities = 44/155 (28%), Positives = 82/155 (52%), Gaps = 9/155 (5%) Query: 217 IVLMKGQAK-GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 +V +K AK GLGF I+GG+ +GI++ ++ GG A DG L+ GD ++ +N S+ Sbjct: 902 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 961 Query: 276 AGLTHQDALQKFKQAKKGLLTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332 G++H A++ + A + +TL + + +++ PS HL+ + + S+ + +DS Sbjct: 962 EGVSHHAAIEILQNAPED-VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS- 1018 Query: 333 SFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLG 367 A++S S ++ R + E S G+ G Sbjct: 1019 --AIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1051 Score = 52.8 bits (125), Expect = 2e-06 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N + Sbjct: 1598 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1652 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336 +TH DA+ + A K TVR + L Sbjct: 1653 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1678 Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396 E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++ Sbjct: 1679 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1731 Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456 G L+ D I ++ +TL EV L P V + +R+ P V K + Sbjct: 1732 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1788 Query: 457 AVENTK 462 A ++TK Sbjct: 1789 APKSTK 1794 Score = 52.4 bits (124), Expect = 3e-06 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%) Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 L K+ GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G Sbjct: 905 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964 Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228 +HH A+ IL+ A E VI K +P N + +S D +++S++ Sbjct: 965 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1024 Query: 1229 E 1229 + Sbjct: 1025 K 1025 Score = 48.9 bits (115), Expect = 3e-05 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ + Sbjct: 1702 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1759 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + L+ R L PS RS S+ TK + S+++ S S P T Sbjct: 1760 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1811 Query: 347 KPNY 350 ++ Sbjct: 1812 NDSF 1815 Score = 44.3 bits (103), Expect = 8e-04 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281 S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG Sbjct: 891 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 950 Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324 D ++ + +++G++ A I++ P+ ++ + K SK Sbjct: 951 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 993 Score = 41.2 bits (95), Expect = 0.007 Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%) Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414 V+L+K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ + Sbjct: 903 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 962 Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447 ++ + IL + P V +++S+ P ++S+ Sbjct: 963 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 993 Score = 40.8 bits (94), Expect = 0.009 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176 +KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T Sbjct: 1698 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1754 Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216 + L + + K T +P + SS SA SA Sbjct: 1755 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1789 Score = 39.7 bits (91), Expect = 0.020 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%) Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172 +T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N + Sbjct: 1598 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1653 Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226 TH DA+ +LR A + + VI + P +PD+ Sbjct: 1654 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1693 Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286 T+T K LGFSL GG SL+ + + I+ I + + +Q D I Sbjct: 1694 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1742 Query: 1287 LGGTAMQGLT 1296 + G + QG+T Sbjct: 1743 VNGVSTQGMT 1752 Score = 33.5 bits (75), Expect = 1.4 Identities = 21/91 (23%), Positives = 40/91 (43%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294 V L K LG S+ GG + + + + A+E + GD +L + G +++G Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237 Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325 T +A ++ ++ + +S SKE Sbjct: 1238 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1268 >gi|18375646 protein tyrosine phosphatase, non-receptor type 13 isoform 1 [Homo sapiens] Length = 2485 Score = 73.9 bits (180), Expect = 9e-13 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%) Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110 +S++ +Y++ + D+ +SS Q Q+ SS K + K D Sbjct: 1309 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1366 Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 V + + LG S+ GG + + + I V V P G A +G I KG+ VL++NG Sbjct: 1367 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1424 Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215 SL+G TH A+ LR Q+ ++ V VT + T + D N+ Sbjct: 1425 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1481 Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271 + V S E V L K S+GLGFS + + + ++F G Sbjct: 1482 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1541 Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + +S + GD IL++ G +++GL++ E + ++ Sbjct: 1542 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1575 Score = 71.6 bits (174), Expect = 5e-12 Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ A++ Sbjct: 1378 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1437 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + + V L S S P+ + C D ++ +T Sbjct: 1438 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1487 Query: 347 KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397 +Y + EV L K + GLG +P S + V L PG A G Sbjct: 1488 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1546 Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452 ++ GD I++++ + + L+ EV + L P V +++ R P P++ L + Sbjct: 1547 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1605 Query: 453 AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512 + AQ + N+ K+ Q S V++ SS + + +K P RR S Sbjct: 1606 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1659 Query: 513 DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569 + ++ S + S+ + S+ V + P ++E + ++ PQ+ P Sbjct: 1660 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1717 Query: 570 PESRDSHP 577 PE DS+P Sbjct: 1718 PEFEDSNP 1725 Score = 58.5 bits (140), Expect = 4e-08 Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 26/256 (10%) Query: 126 LFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPA- 184 L K HQ +RS++ S+ KS A +R P +S S ++ P Sbjct: 999 LVGKPSHQMSRSDAESLAGVTKLN-----NSKSVASLNRSPER--RKHESDSSSIEDPGQ 1051 Query: 185 GKAAGTSRPTRSLSTAQLVQPSGGL---QASVISN------IVLMKGQAK-GLGFSIVGG 234 G + + S++Q+ + + S++S+ +V +K AK GLGF I+GG Sbjct: 1052 AYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111 Query: 235 KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL 294 + +GI++ ++ GG A DG L+ GD ++ +N S+ G++H A++ + A + Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPED- 1170 Query: 295 LTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYR 351 +TL + + +++ PS HL+ + + S+ + +DS A++S S ++ R Sbjct: 1171 VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS---AIDSSSKDHHWSRGTLR 1226 Query: 352 IMVEVSLQKEAGVGLG 367 + E S G+ G Sbjct: 1227 HISENSFGPSGGLREG 1242 Score = 52.8 bits (125), Expect = 2e-06 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N + Sbjct: 1789 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1843 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336 +TH DA+ + A K TVR + L Sbjct: 1844 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1869 Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396 E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++ Sbjct: 1870 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1922 Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456 G L+ D I ++ +TL EV L P V + +R+ P V K + Sbjct: 1923 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1979 Query: 457 AVENTK 462 A ++TK Sbjct: 1980 APKSTK 1985 Score = 52.4 bits (124), Expect = 3e-06 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%) Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 L K+ GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155 Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228 +HH A+ IL+ A E VI K +P N + +S D +++S++ Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215 Query: 1229 E 1229 + Sbjct: 1216 K 1216 Score = 48.9 bits (115), Expect = 3e-05 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ + Sbjct: 1893 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1950 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + L+ R L PS RS S+ TK + S+++ S S P T Sbjct: 1951 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2002 Query: 347 KPNY 350 ++ Sbjct: 2003 NDSF 2006 Score = 44.3 bits (103), Expect = 8e-04 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281 S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141 Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324 D ++ + +++G++ A I++ P+ ++ + K SK Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184 Score = 41.2 bits (95), Expect = 0.007 Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%) Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414 V+L+K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ + Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153 Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447 ++ + IL + P V +++S+ P ++S+ Sbjct: 1154 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 1184 Score = 40.8 bits (94), Expect = 0.009 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176 +KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T Sbjct: 1889 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1945 Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216 + L + + K T +P + SS SA SA Sbjct: 1946 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1980 Score = 39.7 bits (91), Expect = 0.020 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%) Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172 +T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N + Sbjct: 1789 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1844 Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226 TH DA+ +LR A + + VI + P +PD+ Sbjct: 1845 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1884 Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286 T+T K LGFSL GG SL+ + + I+ I + + +Q D I Sbjct: 1885 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1933 Query: 1287 LGGTAMQGLT 1296 + G + QG+T Sbjct: 1934 VNGVSTQGMT 1943 Score = 33.5 bits (75), Expect = 1.4 Identities = 21/91 (23%), Positives = 40/91 (43%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294 V L K LG S+ GG + + + + A+E + GD +L + G +++G Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428 Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325 T +A ++ ++ + +S SKE Sbjct: 1429 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1459 >gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform 2 [Homo sapiens] Length = 2466 Score = 73.9 bits (180), Expect = 9e-13 Identities = 70/274 (25%), Positives = 119/274 (43%), Gaps = 26/274 (9%) Query: 1051 LSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDG 1110 +S++ +Y++ + D+ +SS Q Q+ SS K + K D Sbjct: 1290 ISDVTDYSD--RGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI 1347 Query: 1111 IHVTILHKEEGAGLGFSLAGGAD--LENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 V + + LG S+ GG + + + I V V P G A +G I KG+ VL++NG Sbjct: 1348 FEVELAKNDNS--LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405 Query: 1169 SLKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAAS 1215 SL+G TH A+ LR Q+ ++ V VT + T + D N+ Sbjct: 1406 SLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEK 1462 Query: 1216 ASAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAA 1271 + V S E V L K S+GLGFS + + + ++F G Sbjct: 1463 VKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1522 Query: 1272 SEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 + +S + GD IL++ G +++GL++ E + ++ Sbjct: 1523 AAESGKIDVGDVILKVNGASLKGLSQQEVISALR 1556 Score = 71.6 bits (174), Expect = 5e-12 Identities = 91/368 (24%), Positives = 156/368 (42%), Gaps = 37/368 (10%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ A++ Sbjct: 1359 LGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVET 1418 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + + V L S S P+ + C D ++ +T Sbjct: 1419 LRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKVKKTTQ 1468 Query: 347 KPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSVAHLDG 397 +Y + EV L K + GLG +P S + V L PG A G Sbjct: 1469 VKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESG 1527 Query: 398 RLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQLK--E 452 ++ GD I++++ + + L+ EV + L P V +++ R P P++ L + Sbjct: 1528 KIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTALLTPLQ 1586 Query: 453 AVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSS 512 + AQ + N+ K+ Q S V++ SS + + +K P RR S Sbjct: 1587 SPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSDSSGSG 1640 Query: 513 DSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPL 569 + ++ S + S+ + S+ V + P ++E + ++ PQ+ P Sbjct: 1641 EDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQKIPNK 1698 Query: 570 PESRDSHP 577 PE DS+P Sbjct: 1699 PEFEDSNP 1706 Score = 58.2 bits (139), Expect = 5e-08 Identities = 44/155 (28%), Positives = 82/155 (52%), Gaps = 9/155 (5%) Query: 217 IVLMKGQAK-GLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 +V +K AK GLGF I+GG+ +GI++ ++ GG A DG L+ GD ++ +N S+ Sbjct: 1074 LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSL 1133 Query: 276 AGLTHQDALQKFKQAKKGLLTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSS 332 G++H A++ + A + +TL + + +++ PS HL+ + + S+ + +DS Sbjct: 1134 EGVSHHAAIEILQNAPED-VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS- 1190 Query: 333 SFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLG 367 A++S S ++ R + E S G+ G Sbjct: 1191 --AIDSSSKDHHWSRGTLRHISENSFGPSGGLREG 1223 Score = 53.9 bits (128), Expect = 1e-06 Identities = 47/179 (26%), Positives = 84/179 (46%), Gaps = 22/179 (12%) Query: 1073 SSLQSGQSVISLLSSEELKKL-IEEVKVLDEATLKQLDGIH------------VTILHKE 1119 + L + +SV SL S E +K + + D LD +H +T+++ + Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078 Query: 1120 EGA--GLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175 + A GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G +H Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138 Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTAE 1229 H A+ IL+ A E VI K +P N + +S D +++S+++ Sbjct: 1139 HAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSK 1197 Score = 52.8 bits (125), Expect = 2e-06 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N + Sbjct: 1770 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1824 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336 +TH DA+ + A K TVR + L Sbjct: 1825 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1850 Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396 E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++ Sbjct: 1851 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1903 Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456 G L+ D I ++ +TL EV L P V + +R+ P V K + Sbjct: 1904 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1960 Query: 457 AVENTK 462 A ++TK Sbjct: 1961 APKSTK 1966 Score = 48.9 bits (115), Expect = 3e-05 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ + Sbjct: 1874 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1931 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + L+ R L PS RS S+ TK + S+++ S S P T Sbjct: 1932 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 1983 Query: 347 KPNY 350 ++ Sbjct: 1984 NDSF 1987 Score = 45.4 bits (106), Expect = 4e-04 Identities = 38/149 (25%), Positives = 73/149 (48%), Gaps = 4/149 (2%) Query: 301 TRLTAPPSLCS-HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQ 359 T+L S+ S + SP + S S+ I ++ L+ S R + V+L+ Sbjct: 1019 TKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLK 1078 Query: 360 KEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTL 418 K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ + ++ Sbjct: 1079 KDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSH 1138 Query: 419 NEVYTILSHCDPGPVPIIVSRHPDPQVSE 447 + IL + P V +++S+ P ++S+ Sbjct: 1139 HAAIEILQNA-PEDVTLVISQ-PKEKISK 1165 Score = 44.3 bits (103), Expect = 8e-04 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281 S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG Sbjct: 1063 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122 Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324 D ++ + +++G++ A I++ P+ ++ + K SK Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1165 Score = 40.8 bits (94), Expect = 0.009 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176 +KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T Sbjct: 1870 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1926 Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216 + L + + K T +P + SS SA SA Sbjct: 1927 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1961 Score = 39.7 bits (91), Expect = 0.020 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%) Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172 +T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N + Sbjct: 1770 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1825 Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226 TH DA+ +LR A + + VI + P +PD+ Sbjct: 1826 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1865 Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286 T+T K LGFSL GG SL+ + + I+ I + + +Q D I Sbjct: 1866 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1914 Query: 1287 LGGTAMQGLT 1296 + G + QG+T Sbjct: 1915 VNGVSTQGMT 1924 Score = 33.5 bits (75), Expect = 1.4 Identities = 21/91 (23%), Positives = 40/91 (43%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQG 1294 V L K LG S+ GG + + + + A+E + GD +L + G +++G Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409 Query: 1295 LTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325 T +A ++ ++ + +S SKE Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKE 1440 >gi|157388993 synaptojanin 2 binding protein [Homo sapiens] Length = 145 Score = 73.6 bits (179), Expect = 1e-12 Identities = 42/80 (52%), Positives = 52/80 (65%), Gaps = 3/80 (3%) Query: 226 GLGFSIVGGKDSIY--GPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283 GLGF+IVGG D Y GIYV I GAAA DGRLQEGD+IL +NG+ + L HQDA Sbjct: 22 GLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQDA 81 Query: 284 LQKFKQAKKGLLTLTVRTRL 303 + F+ A ++L V+ RL Sbjct: 82 VDLFRNAGYA-VSLRVQHRL 100 Score = 56.6 bits (135), Expect = 2e-07 Identities = 27/68 (39%), Positives = 44/68 (64%), Gaps = 4/68 (5%) Query: 1122 AGLGFSLAGGADLE----NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGF++ GG D + + I V R+ NG A+ +G +Q+G+++LS+NG+ LK H D Sbjct: 21 SGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVNGQDLKNLLHQD 80 Query: 1178 ALAILRQA 1185 A+ + R A Sbjct: 81 AVDLFRNA 88 Score = 32.0 bits (71), Expect = 4.1 Identities = 20/57 (35%), Positives = 32/57 (56%), Gaps = 2/57 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEIS 409 E++L + +G+G I G Y SGI+V + A LDGRL+ GD+I+ ++ Sbjct: 13 EINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQEGDKILSVN 69 >gi|122937249 glutamate receptor interacting protein 2 [Homo sapiens] Length = 1141 Score = 72.4 bits (176), Expect = 3e-12 Identities = 56/194 (28%), Positives = 91/194 (46%), Gaps = 27/194 (13%) Query: 1119 EEGAGLGFSLAGGADLE---NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTH 1175 +EG GF L GGA + ++ + + V P G A +EG+++ G+ +LS++G L G +H Sbjct: 250 KEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASH 309 Query: 1176 HDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTV 1235 ALA LRQ + TP D+ A+AS V + T Sbjct: 310 ATALATLRQCSHEALFQVEYDVATP----------DTVANASGPLMVEIVKTP------- 352 Query: 1236 TLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 + LG SL SL +TI+RI + ++S + PGD IL + GT+M+ Sbjct: 353 -----GSALGISLT--TTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHC 405 Query: 1296 TRFEAWNIIKALPD 1309 + EA ++ ++ + Sbjct: 406 SLLEATKLLASISE 419 Score = 63.9 bits (154), Expect = 1e-09 Identities = 52/196 (26%), Positives = 90/196 (45%), Gaps = 22/196 (11%) Query: 1106 KQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSI 1165 ++ GI V L K+EG+ LG +++GG D + K V + P GLA++ + G+ + S+ Sbjct: 138 EEFRGITVVELIKKEGSTLGLTISGGTDKDGKP-RVSNLRPGGLAARSDLLNIGDYIRSV 196 Query: 1166 NGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVE 1225 NG L H + + +L+ E R + V +L P A P+ N + Sbjct: 197 NGIHLTRLRHDEIITLLKNVGE-RVVLEVEYELPPPA-PENNPRI-------------IS 241 Query: 1226 STAEATVCTVTLEKMSAGLGFSLEGG-KGSLHGDKPLTINRIFKGAASEQSETVQPGDEI 1284 T + V+L K GF L GG H +PL + + G +++ +++ GD + Sbjct: 242 KTVD-----VSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRL 296 Query: 1285 LQLGGTAMQGLTRFEA 1300 L + G + G + A Sbjct: 297 LSVDGIPLHGASHATA 312 Score = 51.6 bits (122), Expect = 5e-06 Identities = 48/229 (20%), Positives = 105/229 (45%), Gaps = 28/229 (12%) Query: 1092 KLIEEVKV-LDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLA 1150 K++ EV+ + E+ + HV L K+ LG +++ + + + + + +A Sbjct: 634 KVVLEVEFDVAESVIPSSGTFHVK-LPKKRSVELGITISSASRKRGEPLIISDIKKGSVA 692 Query: 1151 SQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSST 1210 + GT++ G+++L+I+ L DA+ ILRQ + +V K+ + ++ Sbjct: 693 HRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCED-----LVKLKIRKD-----EDNS 742 Query: 1211 DSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGA 1270 D + A S TV L++ LG ++ G + P+ I+ + K Sbjct: 743 DELETTGAVS------------YTVELKRYGGPLGITISGTEEPF---DPIVISGLTKRG 787 Query: 1271 ASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRK 1319 +E++ + GD IL + +++G EA ++++ + VT+ I+++ Sbjct: 788 LAERTGAIHVGDRILAINNVSLKGRPLSEAIHLLQVAGE-TVTLKIKKQ 835 Score = 49.3 bits (116), Expect = 2e-05 Identities = 54/212 (25%), Positives = 88/212 (41%), Gaps = 28/212 (13%) Query: 1122 AGLGFSLAGGADLENKVIT---VHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 +G G L GG + + V + P+ A + G +Q G+ VLSING + + T +A Sbjct: 563 SGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEA 622 Query: 1179 LAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLE 1238 +LR A + V L D A S +S T + Sbjct: 623 NQLLRDAALAHKVV-------------LEVEFDVAESVIPSS---------GTFHVKLPK 660 Query: 1239 KMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRF 1298 K S LG ++ S +PL I+ I KG+ + ++ T++PGD++L + + Sbjct: 661 KRSVELGITI--SSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPME 718 Query: 1299 EAWNIIKALPDGPVTIVIRRKSLQSKETTAAG 1330 +A I++ D V + IR+ S E G Sbjct: 719 DAVQILRQCED-LVKLKIRKDEDNSDELETTG 749 Score = 43.5 bits (101), Expect = 0.001 Identities = 64/275 (23%), Positives = 107/275 (38%), Gaps = 53/275 (19%) Query: 201 QLVQPSGGLQASVISNIVLMKGQAKGLGFSIV---GGKDSIYGPIGIYVKTIFAGGAAAA 257 +L P+ +IS V + +G F V G + + + + + GG A Sbjct: 227 ELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTYVRPGGPADR 286 Query: 258 DGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPL 317 +G L+ GD +L ++G + G +H AL +Q CSH Sbjct: 287 EGSLKVGDRLLSVDGIPLHGASHATALATLRQ--------------------CSH----- 321 Query: 318 CRSLSSSTCITKDSSSFALESPSA-PISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYF 376 + F +E A P + A + +MVE+ K G LGI L + Sbjct: 322 -------------EALFQVEYDVATPDTVANASGPLMVEIV--KTPGSALGISLTTTS-L 365 Query: 377 QCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPV-HCLTLNEVYTILSHCDPGPVPI 435 + S I + + P SV G L GD I+ I + + HC L + S + + I Sbjct: 366 RNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEATKLLASISEKVRLEI 425 Query: 436 IVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQW 470 + P PQ S++ L+ + V + ++ H+W Sbjct: 426 L----PVPQ-SQRPLRP--QRQVVKVQRSEQLHRW 453 Score = 41.2 bits (95), Expect = 0.007 Identities = 25/92 (27%), Positives = 43/92 (46%) Query: 1096 EVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGT 1155 E V T+ G + + K G+ LG SL + VIT+ R+ P + + G Sbjct: 328 EYDVATPDTVANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGA 387 Query: 1156 IQKGNEVLSINGKSLKGTTHHDALAILRQARE 1187 + G+ +LSI+G S++ + +A +L E Sbjct: 388 LHPGDHILSIDGTSMEHCSLLEATKLLASISE 419 Score = 39.7 bits (91), Expect = 0.020 Identities = 63/273 (23%), Positives = 101/273 (36%), Gaps = 48/273 (17%) Query: 196 SLSTAQ-LVQPSGGLQASVISNIVLMKGQAKGLGFSIVGG---KDSIYGPIGIYVKTIFA 251 SLS A V P G + + + +VL G G + GG +++ P V I Sbjct: 533 SLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPP--LVCFIEP 590 Query: 252 GGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCS 311 A G LQ GD +L +NG + T ++A Q + A L + L + Sbjct: 591 DSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDA-----ALAHKVVLEVEFDVAE 645 Query: 312 HLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLC 371 + P SS T V L K+ V LGI + Sbjct: 646 SVIP------SSGT----------------------------FHVKLPKKRSVELGITIS 671 Query: 372 SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPG 431 S + + + + GSVAH G L GD+++ I + + + + IL C+ Sbjct: 672 SASRKRG-EPLIISDIKKGSVAHRTGTLEPGDKLLAIDNIRLDNCPMEDAVQILRQCE-- 728 Query: 432 PVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFG 464 + + R + E + AV+ VE ++G Sbjct: 729 DLVKLKIRKDEDNSDELETTGAVSYTVELKRYG 761 Score = 36.2 bits (82), Expect = 0.22 Identities = 51/217 (23%), Positives = 78/217 (35%), Gaps = 42/217 (19%) Query: 214 ISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGE 273 I+ + L+K + LG +I GG D P V + GG AA L GD I +NG Sbjct: 143 ITVVELIKKEGSTLGLTISGGTDKDGKP---RVSNLRPGGLAARSDLLNIGDYIRSVNGI 199 Query: 274 SMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSS 333 + L H + + K + ++ L V L P +P + S T Sbjct: 200 HLTRLRHDEIITLLKNVGERVV-LEVEYELPPP-------APENNPRIISKT-------- 243 Query: 334 FALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG--IFVHTLSPGS 391 V+VSL KE G G L + + + + PG Sbjct: 244 --------------------VDVSLYKE-GNSFGFVLRGGAHEDGHKSRPLVLTYVRPGG 282 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHC 428 A +G L+ GD ++ + P+H + L C Sbjct: 283 PADREGSLKVGDRLLSVDGIPLHGASHATALATLRQC 319 >gi|18375650 protein tyrosine phosphatase, non-receptor type 13 isoform 4 [Homo sapiens] Length = 2490 Score = 71.2 bits (173), Expect = 6e-12 Identities = 59/213 (27%), Positives = 93/213 (43%), Gaps = 28/213 (13%) Query: 1110 GIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKS 1169 GI VT+L + G G I V V P G A +G I KG+ VL++NG S Sbjct: 1379 GISVTVLFDKGGVNTSVRHGG--------IYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1430 Query: 1170 LKGTTHHDALAILR-------------QAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216 L+G TH A+ LR Q+ ++ V VT + T + D N+ Sbjct: 1431 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCT---LSDQNAQGQGPEKV 1487 Query: 1217 SAASDVSVES-TAEATVCTVTLEKMSAGLGFSLEGGKGSLH---GDKPLTINRIFKGAAS 1272 + V S E V L K S+GLGFS + + + ++F G + Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547 Query: 1273 EQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 +S + GD IL++ G +++GL++ E + ++ Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALR 1580 Score = 65.5 bits (158), Expect = 3e-10 Identities = 91/373 (24%), Positives = 156/373 (41%), Gaps = 42/373 (11%) Query: 227 LGFSIV-----GGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQ 281 LG S+ GG ++ GIYVK + GAA +DGR+ +GD +L +NG S+ G TH+ Sbjct: 1378 LGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1437 Query: 282 DALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSA 341 A++ + + V L S S P+ + C D ++ Sbjct: 1438 QAVETLRNTGQ-----VVHLLLEKGQSPTSKEHVPV-----TPQCTLSDQNAQGQGPEKV 1487 Query: 342 PISTAKPNYRIMV-----EVSLQKEAGVGLGIGLCS----VPYFQCISGIFVHTLSPGSV 392 +T +Y + EV L K + GLG +P S + V L PG Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSS-GLGFSFSREDNLIPEQINASIVRVKKLFPGQP 1546 Query: 393 AHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPD---PQVSEQQ 449 A G++ GD I++++ + + L+ EV + L P V +++ R P P++ Sbjct: 1547 AAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAP-EVFLLLCRPPPGVLPEIDTAL 1605 Query: 450 LK--EAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVM 507 L ++ AQ + N+ K+ Q S V++ SS + + +K P RR Sbjct: 1606 LTPLQSPAQVLPNS--SKDSSQPSC--VEQSTSS--DENEMSDKSKKQCKSPSRRDSYSD 1659 Query: 508 IRSSSDSSYMSGSPGGSPGSGSA---EKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQ 564 S + ++ S + S+ + S+ V + P ++E + ++ PQ Sbjct: 1660 SSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTM--FYYPQ 1717 Query: 565 ESPPLPESRDSHP 577 + P PE DS+P Sbjct: 1718 KIPNKPEFEDSNP 1730 Score = 58.5 bits (140), Expect = 4e-08 Identities = 64/256 (25%), Positives = 120/256 (46%), Gaps = 26/256 (10%) Query: 126 LFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPA- 184 L K HQ +RS++ S+ KS A +R P +S S ++ P Sbjct: 999 LVGKPSHQMSRSDAESLAGVTKLN-----NSKSVASLNRSPER--RKHESDSSSIEDPGQ 1051 Query: 185 GKAAGTSRPTRSLSTAQLVQPSGGL---QASVISN------IVLMKGQAK-GLGFSIVGG 234 G + + S++Q+ + + S++S+ +V +K AK GLGF I+GG Sbjct: 1052 AYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGG 1111 Query: 235 KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGL 294 + +GI++ ++ GG A DG L+ GD ++ +N S+ G++H A++ + A + Sbjct: 1112 EKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPED- 1170 Query: 295 LTLTV---RTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYR 351 +TL + + +++ PS HL+ + + S+ + +DS A++S S ++ R Sbjct: 1171 VTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYM-QDS---AIDSSSKDHHWSRGTLR 1226 Query: 352 IMVEVSLQKEAGVGLG 367 + E S G+ G Sbjct: 1227 HISENSFGPSGGLREG 1242 Score = 52.8 bits (125), Expect = 2e-06 Identities = 61/246 (24%), Positives = 100/246 (40%), Gaps = 49/246 (19%) Query: 217 IVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMA 276 I L+K + LGF++ G I G YV + A +DGRL+ GD ++++N + Sbjct: 1794 ITLIKSEKGSLGFTVTKGNQRI----GCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVT 1848 Query: 277 GLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFAL 336 +TH DA+ + A K TVR + L Sbjct: 1849 NMTHTDAVNLLRAASK-----TVRLVI-----------------------------GRVL 1874 Query: 337 ESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLD 396 E P P+ P+ + ++ KE LG LC + +++ ++P SVA ++ Sbjct: 1875 ELPRIPM---LPHLLPDITLTCNKEE---LGFSLCG-GHDSLYQVVYISDINPRSVAAIE 1927 Query: 397 GRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQ 456 G L+ D I ++ +TL EV L P V + +R+ P V K + Sbjct: 1928 GNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLV-LKATRNDLPVVPSS--KRSAVS 1984 Query: 457 AVENTK 462 A ++TK Sbjct: 1985 APKSTK 1990 Score = 52.4 bits (124), Expect = 3e-06 Identities = 35/121 (28%), Positives = 60/121 (49%), Gaps = 7/121 (5%) Query: 1116 LHKEEGAGLGFSLAGGADLE--NKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGT 1173 L K+ GLGF + GG + + I + V P G A +G ++ G+ ++S+N SL+G Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155 Query: 1174 THHDALAILRQAREPRQAVIVTRKLTPEAMPD-----LNSSTDSAASASAASDVSVESTA 1228 +HH A+ IL+ A E VI K +P N + +S D +++S++ Sbjct: 1156 SHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSS 1215 Query: 1229 E 1229 + Sbjct: 1216 K 1216 Score = 48.9 bits (115), Expect = 3e-05 Identities = 38/124 (30%), Positives = 57/124 (45%), Gaps = 10/124 (8%) Query: 227 LGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQK 286 LGFS+ GG DS+Y + Y+ I AA +G LQ D I +NG S G+T ++ + Sbjct: 1898 LGFSLCGGHDSLYQVV--YISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRA 1955 Query: 287 FKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTA 346 + L+ R L PS RS S+ TK + S+++ S S P T Sbjct: 1956 LDMSLPSLVLKATRNDLPVVPS--------SKRSAVSAPKSTKGNGSYSVGSCSQPALTP 2007 Query: 347 KPNY 350 ++ Sbjct: 2008 NDSF 2011 Score = 44.3 bits (103), Expect = 8e-04 Identities = 25/103 (24%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 1223 SVESTAEATVCTVTLEKMSA-GLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPG 1281 S+ S+ E + V L+K + GLGF + GG+ D + I+ + G ++ ++PG Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141 Query: 1282 DEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSK 1324 D ++ + +++G++ A I++ P+ ++ + K SK Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISK 1184 Score = 41.2 bits (95), Expect = 0.007 Identities = 26/93 (27%), Positives = 52/93 (55%), Gaps = 3/93 (3%) Query: 356 VSLQKEAGVGLGIGLCSVPYFQCIS-GIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVH 414 V+L+K+A GLG + + GIF+ +++PG A LDG L+ GD ++ ++ + Sbjct: 1094 VNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLE 1153 Query: 415 CLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSE 447 ++ + IL + P V +++S+ P ++S+ Sbjct: 1154 GVSHHAAIEILQNA-PEDVTLVISQ-PKEKISK 1184 Score = 40.8 bits (94), Expect = 0.009 Identities = 32/100 (32%), Positives = 49/100 (49%), Gaps = 8/100 (8%) Query: 1117 HKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHH 1176 +KEE LGFSL GG D +V+ + + P +A+ EG +Q + + +NG S +G T Sbjct: 1894 NKEE---LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLE 1950 Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASA 1216 + L + + K T +P + SS SA SA Sbjct: 1951 EVNRALDMSLPS-----LVLKATRNDLPVVPSSKRSAVSA 1985 Score = 39.7 bits (91), Expect = 0.020 Identities = 47/190 (24%), Positives = 82/190 (43%), Gaps = 41/190 (21%) Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172 +T++ E+G+ LGF++ G + VH V + A +G ++ G+ ++ +N + Sbjct: 1794 ITLIKSEKGS-LGFTVTKGN--QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN 1849 Query: 1173 TTHHDALAILRQAREPRQAVI------VTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226 TH DA+ +LR A + + VI + P +PD+ Sbjct: 1850 MTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDI-------------------- 1889 Query: 1227 TAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQ 1286 T+T K LGFSL GG SL+ + + I+ I + + +Q D I Sbjct: 1890 -------TLTCNKEE--LGFSLCGGHDSLY--QVVYISDINPRSVAAIEGNLQLLDVIHY 1938 Query: 1287 LGGTAMQGLT 1296 + G + QG+T Sbjct: 1939 VNGVSTQGMT 1948 >gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] Length = 975 Score = 70.5 bits (171), Expect = 1e-11 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ P G A+++G ++ + +L +N + +H Sbjct: 211 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 270 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + R P L TV + L Sbjct: 271 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 301 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I G A+++ +Q GD +L + +++ + Sbjct: 302 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 361 Query: 1296 TRFEAWNIIK 1305 T EA I+K Sbjct: 362 THEEAVAILK 371 Score = 68.2 bits (165), Expect = 5e-11 Identities = 48/118 (40%), Positives = 58/118 (49%), Gaps = 9/118 (7%) Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271 + I L KG KGLGFSI GG I G IYV I GGAA DGRLQ GD +L +N Sbjct: 296 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 354 Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323 S+ +TH++A+ K K G T T PP + SPP+ L S Sbjct: 355 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 412 Score = 64.7 bits (156), Expect = 6e-10 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%) Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 I L +G + GLGFSI GG D+ I GI++ I GGAAA DGRL+ D IL +N Sbjct: 204 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 ++ ++H A++ K+A ++ L VR R Sbjct: 263 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 289 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 +P +VE+ L K GLG + Q I G I+V + G Sbjct: 290 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 336 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427 A DGRL+ GD ++ +++ + +T E IL + Sbjct: 337 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 372 Score = 63.5 bits (153), Expect = 1e-09 Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%) Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244 TS S +T Q PS LQ +V +VL KG GLGF+IVGG+D GI Sbjct: 498 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 549 Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290 +V I AGG A G LQ GD+IL +NG + G +H+ A K A Sbjct: 550 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 595 Score = 54.7 bits (130), Expect = 6e-07 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 +LHK GLGF++ GG D E I V + G A G +Q+G+++LS+NG L+G + Sbjct: 528 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 584 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A A L+ A Q V + + PE Sbjct: 585 HEQAAAALKGA---GQTVTIIAQYQPE 608 Score = 50.4 bits (119), Expect = 1e-05 Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+ +L +N SL+ TH +A Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366 Query: 1179 LAILRQARE 1187 +AIL+ E Sbjct: 367 VAILKNTSE 375 Score = 38.9 bits (89), Expect = 0.033 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292 +TLE+ ++GLGFS+ GG + H GD P + I +I G A+ + ++ D IL++ + Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263 Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319 ++ +A +K V + +RR+ Sbjct: 264 SEVSHSKAVEALKE-AGSIVRLYVRRR 289 Score = 38.5 bits (88), Expect = 0.043 Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%) Query: 1209 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268 S S A+ + + + E V L K S GLGF++ GG+ + + ++ I Sbjct: 501 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 556 Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 G ++ S +Q GD+IL + G ++G + +A +K Sbjct: 557 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593 Score = 33.9 bits (76), Expect = 1.1 Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 2/61 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E++L++ +G+G I G P+ GIF+ + PG A DGRLR D I+ +++ Sbjct: 203 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 262 Query: 413 V 413 V Sbjct: 263 V 263 >gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] Length = 870 Score = 70.5 bits (171), Expect = 1e-11 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 35/190 (18%) Query: 1122 AGLGFSLAGGADL----ENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHD 1177 +GLGFS+AGG D ++ I + ++ P G A+++G ++ + +L +N + +H Sbjct: 106 SGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSK 165 Query: 1178 ALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTL 1237 A+ L++A + R P L TV + L Sbjct: 166 AVEALKEAGS------IVRLYVRRRRPILE-----------------------TVVEIKL 196 Query: 1238 EKMSAGLGFSLEGGKGSLH--GDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGL 1295 K GLGFS+ GG G+ H GD + + +I G A+++ +Q GD +L + +++ + Sbjct: 197 FKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEV 256 Query: 1296 TRFEAWNIIK 1305 T EA I+K Sbjct: 257 THEEAVAILK 266 Score = 68.2 bits (165), Expect = 5e-11 Identities = 48/118 (40%), Positives = 58/118 (49%), Gaps = 9/118 (7%) Query: 214 ISNIVLMKGQAKGLGFSIVGG--KDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELN 271 + I L KG KGLGFSI GG I G IYV I GGAA DGRLQ GD +L +N Sbjct: 191 VVEIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVN 249 Query: 272 GESMAGLTHQDALQKFKQA------KKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSS 323 S+ +TH++A+ K K G T T PP + SPP+ L S Sbjct: 250 NYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLS 307 Score = 64.7 bits (156), Expect = 6e-10 Identities = 62/216 (28%), Positives = 93/216 (43%), Gaps = 52/216 (24%) Query: 217 IVLMKGQAKGLGFSIVGGKDS--IYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGES 274 I L +G + GLGFSI GG D+ I GI++ I GGAAA DGRL+ D IL +N Sbjct: 99 ITLERGNS-GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157 Query: 275 MAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSF 334 ++ ++H A++ K+A ++ L VR R Sbjct: 158 VSEVSHSKAVEALKEA-GSIVRLYVRRR-------------------------------- 184 Query: 335 ALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 +P +VE+ L K GLG + Q I G I+V + G Sbjct: 185 ------------RPILETVVEIKLFK-GPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 231 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSH 427 A DGRL+ GD ++ +++ + +T E IL + Sbjct: 232 AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKN 267 Score = 63.5 bits (153), Expect = 1e-09 Identities = 45/106 (42%), Positives = 56/106 (52%), Gaps = 13/106 (12%) Query: 190 TSRPTRSLSTAQLVQPSGGLQASVI-----SNIVLMKGQAKGLGFSIVGGKDSIYGPIGI 244 TS S +T Q PS LQ +V +VL KG GLGF+IVGG+D GI Sbjct: 393 TSHSQHSTATRQ---PSMTLQRAVSLEGEPRKVVLHKGST-GLGFNIVGGEDGE----GI 444 Query: 245 YVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQA 290 +V I AGG A G LQ GD+IL +NG + G +H+ A K A Sbjct: 445 FVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGA 490 Score = 54.7 bits (130), Expect = 6e-07 Identities = 33/87 (37%), Positives = 48/87 (55%), Gaps = 6/87 (6%) Query: 1115 ILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTT 1174 +LHK GLGF++ GG D E I V + G A G +Q+G+++LS+NG L+G + Sbjct: 423 VLHKGS-TGLGFNIVGGEDGEG--IFVSFILAGGPADLSGELQRGDQILSVNGIDLRGAS 479 Query: 1175 HHDALAILRQAREPRQAVIVTRKLTPE 1201 H A A L+ A Q V + + PE Sbjct: 480 HEQAAAALKGA---GQTVTIIAQYQPE 503 Score = 50.4 bits (119), Expect = 1e-05 Identities = 26/69 (37%), Positives = 41/69 (59%), Gaps = 4/69 (5%) Query: 1123 GLGFSLAGGADLEN----KVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDA 1178 GLGFS+AGG ++ I V ++ G A ++G +Q G+ +L +N SL+ TH +A Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261 Query: 1179 LAILRQARE 1187 +AIL+ E Sbjct: 262 VAILKNTSE 270 Score = 38.9 bits (89), Expect = 0.033 Identities = 26/87 (29%), Positives = 48/87 (55%), Gaps = 3/87 (3%) Query: 1235 VTLEKMSAGLGFSLEGGKGSLH-GDKP-LTINRIFKGAASEQSETVQPGDEILQLGGTAM 1292 +TLE+ ++GLGFS+ GG + H GD P + I +I G A+ + ++ D IL++ + Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158 Query: 1293 QGLTRFEAWNIIKALPDGPVTIVIRRK 1319 ++ +A +K V + +RR+ Sbjct: 159 SEVSHSKAVEALKE-AGSIVRLYVRRR 184 Score = 38.5 bits (88), Expect = 0.043 Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 4/97 (4%) Query: 1209 STDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFK 1268 S S A+ + + + E V L K S GLGF++ GG+ + + ++ I Sbjct: 396 SQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG----EGIFVSFILA 451 Query: 1269 GAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIK 1305 G ++ S +Q GD+IL + G ++G + +A +K Sbjct: 452 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488 Score = 33.9 bits (76), Expect = 1.1 Identities = 21/61 (34%), Positives = 34/61 (55%), Gaps = 2/61 (3%) Query: 355 EVSLQK-EAGVGLGI-GLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSP 412 E++L++ +G+G I G P+ GIF+ + PG A DGRLR D I+ +++ Sbjct: 98 EITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 157 Query: 413 V 413 V Sbjct: 158 V 158 >gi|119120897 par-3 partitioning defective 3 homolog B isoform b [Homo sapiens] Length = 1143 Score = 67.8 bits (164), Expect = 7e-11 Identities = 33/74 (44%), Positives = 46/74 (62%) Query: 220 MKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLT 279 +K +GLGF++V SI+GP I+VK I GAA DGRLQ GD ILE+NG + G T Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 Query: 280 HQDALQKFKQAKKG 293 ++ + + K+G Sbjct: 446 QEELVAMLRSTKQG 459 Score = 46.2 bits (108), Expect = 2e-04 Identities = 36/144 (25%), Positives = 63/144 (43%), Gaps = 17/144 (11%) Query: 1177 DALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVT 1236 DA A L+Q + PR + + +P P + S A + Sbjct: 342 DASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG----------------SNKNAKKIKID 385 Query: 1237 LEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLT 1296 L+K GLGF++ S+HG P+ + I A+ + +Q GD IL++ G + G T Sbjct: 386 LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRT 445 Query: 1297 RFEAWNIIKALPDG-PVTIVIRRK 1319 + E ++++ G ++VI R+ Sbjct: 446 QEELVAMLRSTKQGETASLVIARQ 469 Score = 45.1 bits (105), Expect = 5e-04 Identities = 19/66 (28%), Positives = 36/66 (54%) Query: 1139 ITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKL 1198 I V + P G A ++G +Q G+ +L +NG+ + G T + +A+LR ++ A +V + Sbjct: 410 IFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLVIARQ 469 Query: 1199 TPEAMP 1204 +P Sbjct: 470 EGHFLP 475 Score = 43.9 bits (102), Expect = 0.001 Identities = 65/286 (22%), Positives = 109/286 (38%), Gaps = 48/286 (16%) Query: 197 LSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPI-GIYVKTIFAGGAA 255 + T L P S ++ V + G+ LG +V S+ G I G++++ I + Sbjct: 183 VQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRS 242 Query: 256 AADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKG----LLTLTVRTRLTAPPSLCS 311 +G E + I+++N + T A F+QA K L L + R S+ Sbjct: 243 KREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYEKSVIG 302 Query: 312 HLS--------------PPL-------CRSLSSSTCITKDSSSFALE--SPSAPISTAKP 348 L+ PP+ +L+ + D+S+ + SP P KP Sbjct: 303 SLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKP 362 Query: 349 NYRIM--------------VEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGS 391 + + +++ L+K G+G V I G IFV + P Sbjct: 363 SSPSLSPLMGFGSNKNAKKIKIDLKKGPE---GLGFTVVTRDSSIHGPGPIFVKNILPKG 419 Query: 392 VAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIV 437 A DGRL+ GD I+E++ V T E+ +L G +V Sbjct: 420 AAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465 Score = 31.6 bits (70), Expect = 5.3 Identities = 10/33 (30%), Positives = 26/33 (78%) Query: 1153 EGTIQKGNEVLSINGKSLKGTTHHDALAILRQA 1185 +G ++ ++++++NG+SL G ++H+A+ LR++ Sbjct: 479 DGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 511 >gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens] Length = 728 Score = 65.9 bits (159), Expect = 3e-10 Identities = 58/218 (26%), Positives = 104/218 (47%), Gaps = 18/218 (8%) Query: 1113 VTILHKEEGAGLGFSLAGGA-----DLENKVITVHRVFPNGLASQEGTIQKGNEVLSING 1167 V + K+ G LG ++AGGA DL VI+V P G+ S++G I+ G+ +L+++G Sbjct: 507 VVNIQKDPGESLGMTVAGGASHREWDLPIYVISVE---PGGVISRDGRIKTGDILLNVDG 563 Query: 1168 KSLKGTTHHDALAILRQAREPRQA-VIVTRKLTPEAMPDLNSSTDSAASASAASDVSVES 1226 L + +A+A+L++ + ++ P+ ++ DS + + SD S Sbjct: 564 VELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSW 623 Query: 1227 TA--EATVCT-----VTLEKMSAG-LGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETV 1278 E C + L + +AG LGF + GG +G+KP I I +G + + Sbjct: 624 VMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683 Query: 1279 QPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVI 1316 + GD +L + G + G+ ++K L G +T+ I Sbjct: 684 RCGDILLAVNGRSTSGMIHACLARLLKEL-KGRITLTI 720 Score = 60.8 bits (146), Expect = 8e-09 Identities = 49/196 (25%), Positives = 91/196 (46%), Gaps = 17/196 (8%) Query: 219 LMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGL 278 + K + LG ++ GG + IYV ++ GG + DGR++ GD +L ++G + + Sbjct: 510 IQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEV 569 Query: 279 THQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALES 338 + +A+ K+ ++ + + P CS SP +L S+ + S S Sbjct: 570 SRSEAVALLKRTSSSIVLKALEVKEYEPQEDCS--SP---AALDSNHNMAPPSD----WS 620 Query: 339 PSAPISTAKPN--YRIMVEVSLQKEAGVGLGIGLCSVPYFQCISG---IFVHTLSPGSVA 393 PS + P Y V + AG +G C V ++ +G F+ ++ G+ A Sbjct: 621 PSWVMWLELPRCLYNCKDIVLRRNTAG---SLGFCIVGGYEEYNGNKPFFIKSIVEGTPA 677 Query: 394 HLDGRLRCGDEIVEIS 409 + DGR+RCGD ++ ++ Sbjct: 678 YNDGRIRCGDILLAVN 693 Score = 58.9 bits (141), Expect = 3e-08 Identities = 33/84 (39%), Positives = 49/84 (58%), Gaps = 1/84 (1%) Query: 216 NIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESM 275 +IVL + A LGF IVGG + G ++K+I G A DGR++ GD +L +NG S Sbjct: 638 DIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRST 697 Query: 276 AGLTHQDALQKFKQAKKGLLTLTV 299 +G+ H L + + KG +TLT+ Sbjct: 698 SGMIHA-CLARLLKELKGRITLTI 720 Score = 55.1 bits (131), Expect = 4e-07 Identities = 49/225 (21%), Positives = 95/225 (42%), Gaps = 11/225 (4%) Query: 1109 DGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGK 1168 D HV + LG L D + + V G+A + G +++ + VL+ING Sbjct: 378 DSFHVILNKSSPEEQLGIKLVRKVDEPG--VFIFNVLDGGVAYRHGQLEENDRVLAINGH 435 Query: 1169 SLKGTTHHDALAILRQAREPRQAVIVTRKL---TPEAMPDLNSSTDSAASASAASDVSVE 1225 L+ + A A L QA E R ++V+R++ +P+ + +++ + S + Sbjct: 436 DLRYGSPESA-AHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP 494 Query: 1226 STAEATVC----TVTLEK-MSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQP 1280 T+ V ++K LG ++ GG D P+ + + G + ++ Sbjct: 495 KPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKT 554 Query: 1281 GDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKE 1325 GD +L + G + ++R EA ++K V + K + +E Sbjct: 555 GDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQE 599 Score = 45.1 bits (105), Expect = 5e-04 Identities = 37/188 (19%), Positives = 80/188 (42%), Gaps = 19/188 (10%) Query: 243 GIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTR 302 G+++ + GG A G+L+E D +L +NG + + + A + +++ + + R Sbjct: 405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQV 464 Query: 303 LTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMV----EVSL 358 P + +S+ P +T KP + + V++ Sbjct: 465 RQRSPDIFQEAG--------------WNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNI 510 Query: 359 QKEAGVGLGIGLC-SVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLT 417 QK+ G LG+ + + + I+V ++ PG V DGR++ GD ++ + + ++ Sbjct: 511 QKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVS 570 Query: 418 LNEVYTIL 425 +E +L Sbjct: 571 RSEAVALL 578 Score = 40.8 bits (94), Expect = 0.009 Identities = 25/76 (32%), Positives = 44/76 (57%), Gaps = 3/76 (3%) Query: 224 AKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDA 283 ++ L +VGG ++ + I ++ I+ G A DGRL GD IL++NG ++ + H A Sbjct: 283 SESLSIRLVGGSETPL--VHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYA 340 Query: 284 LQKFKQAKKGLLTLTV 299 ++ +Q + +L LTV Sbjct: 341 VRLLRQPCQ-VLWLTV 355 Score = 39.3 bits (90), Expect = 0.025 Identities = 17/72 (23%), Positives = 37/72 (51%) Query: 1113 VTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKG 1172 + I + L L GG++ I + ++ +G+ +++G + G+ +L +NG + Sbjct: 275 IKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 334 Query: 1173 TTHHDALAILRQ 1184 H+ A+ +LRQ Sbjct: 335 VPHNYAVRLLRQ 346 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.310 0.127 0.361 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 57,596,013 Number of Sequences: 37866 Number of extensions: 3117173 Number of successful extensions: 16242 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 160 Number of HSP's successfully gapped in prelim test: 602 Number of HSP's that attempted gapping in prelim test: 13027 Number of HSP's gapped (non-prelim): 3424 length of query: 1332 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1218 effective length of database: 13,930,794 effective search space: 16967707092 effective search space used: 16967707092 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.