Search of human proteins with 148746189

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|148746189 multiple PDZ domain protein [Homo sapiens]
         (2041 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|148746189 multiple PDZ domain protein [Homo sapiens]              3986   0.0  
gi|112382257 InaD-like [Homo sapiens]                                 897   0.0  
gi|24025688 ligand of numb-protein X 2 [Homo sapiens]                 223   1e-57
gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]      209   2e-53
gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]      209   2e-53
gi|45827729 scribble isoform b [Homo sapiens]                         150   1e-35
gi|45827731 scribble isoform a [Homo sapiens]                         150   1e-35
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...   139   3e-32
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...   139   3e-32
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...   139   3e-32
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                     139   4e-32
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                      139   4e-32
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]          138   6e-32
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]          138   6e-32
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...   134   9e-31
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...   131   6e-30
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...   129   3e-29
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...   129   3e-29
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...   127   1e-28
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...   127   1e-28
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...   125   3e-28
gi|87196343 PDZ domain containing 2 [Homo sapiens]                    124   1e-27
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...   123   2e-27
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                     122   4e-27
gi|218505835 membrane-associated guanylate kinase-related  3 iso...   122   5e-27
gi|155969695 membrane-associated guanylate kinase-related  3 iso...   122   5e-27
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]   114   7e-25
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...   109   3e-23
gi|119120907 par-3 partitioning defective 3 homolog B isoform a ...   107   9e-23
gi|119120903 par-3 partitioning defective 3 homolog B isoform c ...   107   9e-23

>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 3986 bits (10337), Expect = 0.0
 Identities = 2041/2041 (100%), Positives = 2041/2041 (100%)

Query: 1    MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKD 60
            MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKD
Sbjct: 1    MLEAIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKD 60

Query: 61   QVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACD 120
            QVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACD
Sbjct: 61   QVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACD 120

Query: 121  EFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDG 180
            EFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDG
Sbjct: 121  EFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDG 180

Query: 181  RLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAA 240
            RLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAA
Sbjct: 181  RLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAA 240

Query: 241  STISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGD 300
            STISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGD
Sbjct: 241  STISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGD 300

Query: 301  HILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPE 360
            HILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPE
Sbjct: 301  HILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPE 360

Query: 361  LRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDG 420
            LRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDG
Sbjct: 361  LRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDG 420

Query: 421  RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA 480
            RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA
Sbjct: 421  RIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDA 480

Query: 481  DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540
            DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK
Sbjct: 481  DLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540

Query: 541  WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELL 600
            WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELL
Sbjct: 541  WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELL 600

Query: 601  EVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVD 660
            EVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVD
Sbjct: 601  EVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVD 660

Query: 661  LGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDP 720
            LGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDP
Sbjct: 661  LGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDP 720

Query: 721  IDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVR 780
            IDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVR
Sbjct: 721  IDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVR 780

Query: 781  IGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDEST 840
            IGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDEST
Sbjct: 781  IGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDEST 840

Query: 841  FESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSL 900
            FESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSL
Sbjct: 841  FESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSL 900

Query: 901  EELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSE 960
            EELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSE
Sbjct: 901  EELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSE 960

Query: 961  VISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGM 1020
            VISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGM
Sbjct: 961  VISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGM 1020

Query: 1021 TVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLI 1080
            TVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLI
Sbjct: 1021 TVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLI 1080

Query: 1081 GPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQN 1140
            GPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQN
Sbjct: 1081 GPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQN 1140

Query: 1141 TAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNG 1200
            TAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNG
Sbjct: 1141 TAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNG 1200

Query: 1201 TLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYP 1260
            TLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYP
Sbjct: 1201 TLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYP 1260

Query: 1261 KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKI 1320
            KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKI
Sbjct: 1261 KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKI 1320

Query: 1321 SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGI 1380
            SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGI
Sbjct: 1321 SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGI 1380

Query: 1381 DPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMA 1440
            DPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMA
Sbjct: 1381 DPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMA 1440

Query: 1441 VCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEE 1500
            VCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEE
Sbjct: 1441 VCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEE 1500

Query: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
            DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI
Sbjct: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560

Query: 1561 HAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATC 1620
            HAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATC
Sbjct: 1561 HAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATC 1620

Query: 1621 PIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEV 1680
            PIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEV
Sbjct: 1621 PIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEV 1680

Query: 1681 NGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSI 1740
            NGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSI
Sbjct: 1681 NGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSI 1740

Query: 1741 VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLS 1800
            VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLS
Sbjct: 1741 VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLS 1800

Query: 1801 SFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVP 1860
            SFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVP
Sbjct: 1801 SFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVP 1860

Query: 1861 IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1920
            IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD
Sbjct: 1861 IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1920

Query: 1921 VSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH 1980
            VSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH
Sbjct: 1921 VSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH 1980

Query: 1981 GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
            GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL
Sbjct: 1981 GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040

Query: 2041 S 2041
            S
Sbjct: 2041 S 2041


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score =  897 bits (2317), Expect = 0.0
 Identities = 684/1964 (34%), Positives = 1002/1964 (51%), Gaps = 327/1964 (16%)

Query: 4    AIDKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVN 63
            A DK + L   +RL+ KL+E+GD +  +KLS+    L+SPLF+QIL+LQ S++QLK Q+N
Sbjct: 6    ATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLN 65

Query: 64   -IATSATSNIEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEF 122
             I +  ++N +++    L      ++ N +     NN  +  L  P  P +      ++F
Sbjct: 66   HIPSDCSANFDFSR-KGLLVFTDGSITNGNVHRPSNNSTVSGLF-PWTPKLGN----EDF 119

Query: 123  DQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRL 182
            + +I+ MAQGR +E  ++ +P +GGLGFSVV LRS+N G++ IFV+++Q GSVA RD RL
Sbjct: 120  NSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRL 179

Query: 183  KETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAAST 242
            KE DQILAIN   LDQ I+HQQAI++LQ+   +++L++AR        P+ ++S S +S+
Sbjct: 180  KENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR-------EPVHTKS-STSSS 231

Query: 243  ISAHSNP--VHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGD 300
            ++  + P  V W H+E +EL+NDGSGLGFGI+GGK +GV+V+TI+PGG+AD+ GRL +GD
Sbjct: 232  LNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDGRLQTGD 291

Query: 301  HILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT----APTALGITLSSSPT 356
            HILKIG T++ GM+SEQVAQVLR CGN V++++AR    + +    AP AL + L   PT
Sbjct: 292  HILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVAL---PT 348

Query: 357  STPELRVDASTQKGEES---ETFDVELT-KNVQGLGITIAGYIGDKKL-EPSGIFVKSIT 411
                    AS   G +S   ET++VEL  K+ Q LGI I GY+G     E SGI+VKSI 
Sbjct: 349  V-------ASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSII 401

Query: 412  KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR-------GM 464
              SA  H+G IQ+ D+I+AVDG N+QGF N   VEVLR+ GQ V LTL+RR        +
Sbjct: 402  PGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPL 461

Query: 465  KQEAELMSREDVTKDADLSPVNASIIKENYE-KDEDF---LSSTRNTNILPTEEEGYPLL 520
            +  ++  +  +  K   L    A   + N + +DE+    + + +N NI   E       
Sbjct: 462  EPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALE------- 514

Query: 521  SAEIEEIEDAQKQEAALLTKWQRIMGINYEIVV----------AHVSKFSE-----NSGL 565
              ++E++ D+ + E  L ++W+ ++G +YE++V          A + K+S+        L
Sbjct: 515  --KLEKVPDSPENE--LKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRL 570

Query: 566  GISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE 625
            G+ +++  GHH+I S++  GPV   G L   DELLEVNG+ L G++ ++ V+ LKE+P  
Sbjct: 571  GVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPP 630

Query: 626  VTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTE 685
             T+VCCRR      ++ +D     +  L E   VD    + + E +D             
Sbjct: 631  FTLVCCRRLF--DDEASVDEPRRTETSLPE-TEVDHNMDVNTEEDDD------------- 674

Query: 686  EVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRL 745
                 LA+W   ++ +EL K  KGLGFSILDYQDP+DP  +VI+IRSLV  G+AE+ G L
Sbjct: 675  ---GELALWSPEVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGL 731

Query: 746  LPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEG-----YVSAKE 800
            LPGDRL+ VN+  L+N+SL EAVE LK  P G V +G+ KPL    EE      + S+ E
Sbjct: 732  LPGDRLVSVNEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNE 791

Query: 801  D--SFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQAS 858
            D   F    H    + + + P         G  D     E   + P+     S +S Q  
Sbjct: 792  DKTEFSGTIHDINSSLILEAP--------KGFRDEPYFKEELVDEPFLDLGKSFHSQQKE 843

Query: 859  ILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPS 918
            I                   S    ++ E     + ++    E L  +     QD   PS
Sbjct: 844  IEQ-----------------SKEAWEMHEFLTPRLQEMDEEREMLVDEEYELYQD---PS 883

Query: 919  VDISMGPASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKG 978
              + + P S   I + TP  ++             E H  ++ +   E PS   ++    
Sbjct: 884  PSMELYPLS--HIQEATPVPSV------------NELHFGTQWLHDNE-PSESQEARTGR 928

Query: 979  SEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIH 1038
            + Y  E        E VM +N   ES   ++   +GNS  G     + + L  + ++ + 
Sbjct: 929  TVYSQEAQPYGYCPENVMKENFVMESLP-SVPSTEGNSQQGR--FDDLENLNSLAKTSLD 985

Query: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITY-VPAEHLEEF 1097
             G I  D                                 + GP + I   V A+  E+ 
Sbjct: 986  LGMIPND---------------------------------VQGPSLLIDLPVVAQRREQE 1012

Query: 1098 KISLGQ-QSGRVMALDIFSSYTG-------RDIPELPEREEGEGEESELQNTAYSNWNQP 1149
             + L Q Q+ RV++    S+YTG        D  ELPEREEGEGEE+      +S+W  P
Sbjct: 1013 DLPLYQHQATRVISK--ASAYTGMLSSRYATDTCELPEREEGEGEET----PNFSHWGPP 1066

Query: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
            R VE++REP+ SLGISIVGG+ +  RL NGE ++GIFIK VLEDSPAGK   LK GD+I+
Sbjct: 1067 RIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL 1126

Query: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNP 1269
            EV G+DL++ASH +AVEAI+ AGNPVVF+VQS+ + PR  P      N++ K N  + N 
Sbjct: 1127 EVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIP------NVHNKANKITGNQ 1180

Query: 1270 FADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDK-ED 1328
                   N D    + + +    P   +PPP                   ++ D D+ E+
Sbjct: 1181 -------NQDTQEKKEKRQGTAPPPMKLPPP----------------YKALTDDSDENEE 1217

Query: 1329 EFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGK 1388
            E  ++ + IR+RY  L GELH+IELEK  +GLGLSLAGNKDRSRMS+F+VGI+P G A  
Sbjct: 1218 EDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAA 1277

Query: 1389 DGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVE 1448
            DGR++I DELLEIN QILYGRSHQNAS+IIK APSKVK++FIRN+DAVNQMAV P     
Sbjct: 1278 DGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPS 1337

Query: 1449 PLPSNSENLQNKETEPTVTTSDAAVDL--------SSFKNVQHLELPKDQGGLGIAISEE 1500
              PS+ E+     TEP  +  D +V++         SFK +   ++ + +    ++ S +
Sbjct: 1338 SSPSSIED--QSGTEPISSEEDGSVEVGIKQLPESESFK-LAVSQMKQQKYPTKVSFSSQ 1394

Query: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
            +     +  + + H   A           L+VD       P ++ I  +   +  + L+I
Sbjct: 1395 EI---PLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSI 1451

Query: 1561 --HAENPDSQAV-----PSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIF 1613
                + P +  V        A A  G      Q L V          +RN+S        
Sbjct: 1452 VGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEV------NGVDLRNSSHEEAITAL 1505

Query: 1614 ASDPATCPIIP-------GCETTIEI------SKGRTGLGLSIVGGSDTLLGAIIIHEVY 1660
               P    ++          E  +EI       K   GLGLSIVG  +     + I ++ 
Sbjct: 1506 RQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNG--SGVFISDIV 1563

Query: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR---------- 1710
            + GAA  DGRL  GDQIL VNG D+R A+ +    +L+     V+L + R          
Sbjct: 1564 KGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAGSWTSAR 1623

Query: 1711 --------------------------------------DEAPYKEEEVCDTLTIELQKKP 1732
                                                  D +        +  T+E+ ++ 
Sbjct: 1624 TTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTVEINREL 1683

Query: 1733 GKGLGLSIVGKR----NDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAV 1788
               LG+SI G R     D  VF++ I   G+A    +L  GD+I+ +NG+ +   +   V
Sbjct: 1684 SDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADV 1743

Query: 1789 AALLK----------VSEGSLSSFTFPLSGSSTSESLESSSKKN 1822
              LLK          V++ ++S+    L   ST   L S + ++
Sbjct: 1744 VNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPTAEH 1787



 Score =  423 bits (1088), Expect = e-118
 Identities = 274/690 (39%), Positives = 384/690 (55%), Gaps = 126/690 (18%)

Query: 1360 LGLSLAGNKD--------RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411
            LG+S+ G +              +FI  +  +  AGK   L+  D++LE++G  L   SH
Sbjct: 1079 LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASH 1138

Query: 1412 QNASSIIKCAPSKV----------------------KIIFIRNKDAVNQMAVCPGNAVEP 1449
              A   IK A + V                      KI   +N+D   +     G A  P
Sbjct: 1139 SEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPP 1198

Query: 1450 LP------SNSENLQNKETEPTVTTSDAAVDLSSFKNVQHL-ELPKDQGGLGIAIS--EE 1500
            +       + +++    E E   T        +      H+ EL KD+ GLG++++  ++
Sbjct: 1199 MKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKD 1258

Query: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLT- 1559
             +   + +  +   G AA DGR+++GD++L ++++I+ G   +   +++KTA   VKL  
Sbjct: 1259 RSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVF 1318

Query: 1560 IHAENPDSQA------VPSAAGAASGEKKNSSQSLMVPQSGS--------PEPESIR--- 1602
            I  E+  +Q       VPS++  +S E ++ ++ +   + GS        PE ES +   
Sbjct: 1319 IRNEDAVNQMAVTPFPVPSSS-PSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAV 1377

Query: 1603 -----------------------NTSRSSTPAIFAS----------DPATCPIIPGCETT 1629
                                    +S  ST A F            DPATCPI+PG E  
Sbjct: 1378 SQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMI 1437

Query: 1630 IEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKAT 1689
            IEISKGR+GLGLSIVGG DT L AI+IHEVYEEGAA +DGRLWAGDQILEVNG+DLR ++
Sbjct: 1438 IEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSS 1497

Query: 1690 HDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGV 1749
            H+EAI  LRQTPQ+VRL +YRDEA Y++EE  +   ++LQKK G+GLGLSIVGKRN +GV
Sbjct: 1498 HEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKRNGSGV 1557

Query: 1750 FVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSL---------S 1800
            F+SDIVKGG AD DGRL+QGDQIL VNGED+RNA+QE VA +LK ++G +          
Sbjct: 1558 FISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLRAG 1617

Query: 1801 SFTFPLSGSSTSESLESSSKKN---ALASEIQGL-----------------------RTV 1834
            S+T   + S  S+  + S+  +   + A  I GL                       RTV
Sbjct: 1618 SWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNSGTDMEPRTV 1677

Query: 1835 EMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEG 1894
            E+ +  +D+LGISIAGG GSPLGD+P+FIAM+  +GVAA+TQKL+VGDRIV+I G   +G
Sbjct: 1678 EINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDG 1737

Query: 1895 MTHTQAVNLLKNASGSIEMQVVAGGDVSVV 1924
            ++H   VNLLKNA G I +QVVA  ++S +
Sbjct: 1738 LSHADVVNLLKNAYGRIILQVVADTNISAI 1767



 Score =  124 bits (312), Expect = 7e-28
 Identities = 106/341 (31%), Positives = 165/341 (48%), Gaps = 52/341 (15%)

Query: 1731 KPGKGLGLSIVGKRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEA 1787
            K   GLGLSIVG ++     + + ++ + G A  DGRL  GDQIL VNG D+RN++ +EA
Sbjct: 1442 KGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEA 1501

Query: 1788 VAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGIS 1847
            + AL +  +          +     E+LE              +  V+++K     LG+S
Sbjct: 1502 ITALRQTPQKVRLVVYRDEAHYRDEENLE--------------IFPVDLQKKAGRGLGLS 1547

Query: 1848 IAG---GVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLL 1904
            I G   G G       +FI+ +   G A    +L  GD+I+++ G      +      +L
Sbjct: 1548 IVGKRNGSG-------VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATIL 1600

Query: 1905 KNASGSIEMQVV---AGGDVSVVTGHQ-----QEPASSSLS------FTGLTS------- 1943
            K A G +++++    AG   S  T  Q     Q+ A SS         TGL +       
Sbjct: 1601 KCAQGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRV 1660

Query: 1944 SSIFQDDLGP---PQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDG 2000
            S   Q + G    P+   I  E   D LG SI GG GSP GD+P+++  + A G A+   
Sbjct: 1661 SDPSQKNSGTDMEPRTVEINRELS-DALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQ 1719

Query: 2001 RLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2041
            +LK GD+I+++NGQ L+G++H + V +LK   G + L V++
Sbjct: 1720 KLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVVA 1760



 Score =  117 bits (292), Expect = 2e-25
 Identities = 94/328 (28%), Positives = 159/328 (48%), Gaps = 25/328 (7%)

Query: 1726 IELQKKPGKGLGLSIVGKRNDT----GVFVSDIVKGGIADADGRLMQGDQILMVNGEDV- 1780
            I++++    GLG S+V  R+       +FV D+  G +AD D RL + DQIL +N   + 
Sbjct: 135  IDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLD 194

Query: 1781 RNATQEAVAALLKVSEGSLSSFTF--PL-SGSSTSESLESSSKKNALA-SEIQGLRTVEM 1836
            +N + +   ALL+ + GSL       P+ + SSTS SL  ++    +    ++ +  +  
Sbjct: 195  QNISHQQAIALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVCWGHVEEVELIND 254

Query: 1837 KKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMT 1896
              G    LG  I GG  S      + +  + P G+A +  +L+ GD I+ I GT+ +GMT
Sbjct: 255  GSG----LGFGIVGGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305

Query: 1897 HTQAVNLLKNASGSIEMQVVA--GGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP 1954
              Q   +L+N   S+ M V     GD+SV       PA+  ++   + S     D     
Sbjct: 306  SEQVAQVLRNCGNSVRMLVARDPAGDISVTP---PAPAALPVALPTVASKGPGSDSSLFE 362

Query: 1955 QCKSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVN 2012
                  + +    LG  IVG  G+ H G+   IYVK++    AA  +G ++  D+I+AV+
Sbjct: 363  TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVD 422

Query: 2013 GQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
            G +++G  + + V +L+     V L ++
Sbjct: 423  GVNIQGFANHDVVEVLRNAGQVVHLTLV 450



 Score =  114 bits (285), Expect = 1e-24
 Identities = 161/704 (22%), Positives = 291/704 (41%), Gaps = 97/704 (13%)

Query: 1347 ELHMIELEKGHSG-LGLSLAGNKDRS--RMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            ++  I++E+  +G LG S+   + ++  ++ +F+  + P   A +D RL+  D++L IN 
Sbjct: 131  QIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINH 190

Query: 1404 QIL-YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
              L    SHQ A ++++     +++I  R               V    S S +L +   
Sbjct: 191  TPLDQNISHQQAIALLQQTTGSLRLIVAREP-------------VHTKSSTSSSLNDTTL 237

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
              TV           + +V+ +EL  D  GLG  I    T SGV+++++   G+A  DGR
Sbjct: 238  PETVC----------WGHVEEVELINDGSGLGFGIVGGKT-SGVVVRTIVPGGLADRDGR 286

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
            L+ GD IL +    V G   E+   +L+    +V++ + A +P        AG  S    
Sbjct: 287  LQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLV-ARDP--------AGDIS---- 333

Query: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLS 1642
                  + P + +  P ++        P + +  P +   +        + K    LG+ 
Sbjct: 334  ------VTPPAPAALPVAL--------PTVASKGPGSDSSLFETYNVELVRKDGQSLGIR 379

Query: 1643 IVGGSDTL----LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLR 1698
            IVG   T        I +  +    AA  +G +   D+I+ V+G++++   + + + VLR
Sbjct: 380  IVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLR 439

Query: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGG 1758
               Q V LTL R +          + T  L+    +G   ++V       +F++  V+  
Sbjct: 440  NAGQVVHLTLVRRKT--------SSSTSPLEPPSDRG---TVVEPLKPPALFLTGAVETE 488

Query: 1759 IADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS---EGSLSSFTFPLSGSSTSESL 1815
              + DG     D+ +    + ++N   +A+  L KV    E  L S    L G      +
Sbjct: 489  -TNVDGE----DEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVMV 543

Query: 1816 ESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQT 1875
             +   + A  +E+Q       K  P  +L +    GV     D   +I+ +   G     
Sbjct: 544  ATLDTQIADDAELQKYS----KLLPIHTLRL----GVEVDSFDGHHYISSIVSGGPVDTL 595

Query: 1876 QKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM---QVVAGGDVSVVTGHQQEPA 1932
              L+  D ++ + G    G +  +AV+ LK       +   + +   + SV    + E +
Sbjct: 596  GLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRRTETS 655

Query: 1933 SSSLSFTGLTSSSIFQDDLGP-----PQCKSITLERGPDGLGFSIVGGYGSPHGDLP--I 1985
                        +  +DD G      P+ K + L +   GLGFSI+  Y  P       I
Sbjct: 656  LPETEVDHNMDVNTEEDDDGELALWSPEVKIVELVKDCKGLGFSILD-YQDPLDPTRSVI 714

Query: 1986 YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK 2029
             ++++ A G A   G L  GD++++VN   L+  +  EAV ILK
Sbjct: 715  VIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILK 758



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 129/600 (21%), Positives = 231/600 (38%), Gaps = 135/600 (22%)

Query: 1479 KNVQHLELPKDQ-GGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVD 1533
            + ++++++ +   GGLG ++    S+      + +K +    VA  D RLK  DQILA++
Sbjct: 130  RQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAIN 189

Query: 1534 DEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQS 1593
                   P+++ IS                    QA+      A  ++   S  L+V + 
Sbjct: 190  HT-----PLDQNIS------------------HQQAI------ALLQQTTGSLRLIVAR- 219

Query: 1594 GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGA 1653
                 E +   S +S+     + P T  +  G    +E+    +GLG  IVGG  +    
Sbjct: 220  -----EPVHTKSSTSSSLNDTTLPET--VCWGHVEEVELINDGSGLGFGIVGGKTS---G 269

Query: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA 1713
            +++  +   G A +DGRL  GD IL++ G +++  T ++   VLR     VR+ + RD A
Sbjct: 270  VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPA 329

Query: 1714 ------------------------PYKEEEVCDTLTIELQKKPGKGLGLSIVG------K 1743
                                    P  +  + +T  +EL +K G+ LG+ IVG       
Sbjct: 330  GDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHT 389

Query: 1744 RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFT 1803
               +G++V  I+ G  A  +G +   D+I+ V+G +++      V  +L+ + G +   T
Sbjct: 390  GEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLR-NAGQVVHLT 448

Query: 1804 FPLSGSSTSES-LESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIF 1862
                 +S+S S LE  S +                            G V  PL    +F
Sbjct: 449  LVRRKTSSSTSPLEPPSDR----------------------------GTVVEPLKPPALF 480

Query: 1863 IAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVS 1922
            +     T      +   + +RI T+   + + +   + V            + + G D  
Sbjct: 481  LTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYE 540

Query: 1923 VVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSI----TLERGPDGLGFSIVGGYGS 1978
            V+                 T  +   DD    +   +    TL  G +      V  +  
Sbjct: 541  VMVA---------------TLDTQIADDAELQKYSKLLPIHTLRLGVE------VDSFDG 579

Query: 1979 PHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
             H     Y+ ++ + G     G L+  D+++ VNG  L G +  EAV+ LK      TL+
Sbjct: 580  HH-----YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634



 Score = 96.3 bits (238), Expect = 3e-19
 Identities = 72/246 (29%), Positives = 122/246 (49%), Gaps = 21/246 (8%)

Query: 1795 SEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGS 1854
            S  S  S  FP +    +E   S  ++ A   +I+    +++++  T  LG S+      
Sbjct: 99   SNNSTVSGLFPWTPKLGNEDFNSVIQQMAQGRQIE---YIDIERPSTGGLGFSVVALRSQ 155

Query: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTE-GMTHTQAVNLLKNASGSIEM 1913
             LG V IF+  + P  VA + Q+L+  D+I+ I  T  +  ++H QA+ LL+  +GS+ +
Sbjct: 156  NLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRL 215

Query: 1914 QVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIV 1973
             +VA   V     H +   SSSL+ T L  +  +         + + L     GLGF IV
Sbjct: 216  -IVAREPV-----HTKSSTSSSLNDTTLPETVCWG------HVEEVELINDGSGLGFGIV 263

Query: 1974 GGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKG 2033
            GG  S      + V+T+   G A  DGRL+ GD I+ + G +++G+T E+   +L+    
Sbjct: 264  GGKTSG-----VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGN 318

Query: 2034 TVTLMV 2039
            +V ++V
Sbjct: 319  SVRMLV 324



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 114/453 (25%), Positives = 177/453 (39%), Gaps = 144/453 (31%)

Query: 1726 IELQKKPGKGLGLSIVGKRNDT----------GVFVSDIVKGGIADADGRLMQGDQILMV 1775
            +E+ ++P   LG+SIVG +             G+F+  +++   A     L  GD+IL V
Sbjct: 1069 VEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEV 1128

Query: 1776 NGEDVRNATQ-EAVAALLKVSEG------SLSSF----------TFPLSGSSTSESLESS 1818
            +G D++NA+  EAV A+            SLSS              ++G+   ++ E  
Sbjct: 1129 SGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKK 1188

Query: 1819 SKKNALA-----------------------------------SEIQG-LRTVEMKKGPTD 1842
             K+   A                                   +++ G L  +E++K   +
Sbjct: 1189 EKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDK-N 1247

Query: 1843 SLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQ--- 1899
             LG+S+AG        + IF+  ++P G AA   ++R+GD ++ I      G +H     
Sbjct: 1248 GLGLSLAGN--KDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASA 1305

Query: 1900 ------------------AVNLL--------KNASGSIEMQ-----VVAGGDVSVVTGHQ 1928
                              AVN +         ++  SIE Q     + +  D SV  G +
Sbjct: 1306 IIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIK 1365

Query: 1929 QEPASSS----------------LSFTG-----------------LTSSSIFQDDLG--- 1952
            Q P S S                +SF+                   T    FQ  L    
Sbjct: 1366 QLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDP 1425

Query: 1953 ------PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGD 2006
                  P Q   I + +G  GLG SIVGG  +P     I +  V+ +GAA+ DGRL  GD
Sbjct: 1426 ATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLN--AIVIHEVYEEGAAARDGRLWAGD 1483

Query: 2007 QIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            QI+ VNG  L   +HEEA+  L++T   V L+V
Sbjct: 1484 QILEVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 77/296 (26%), Positives = 124/296 (41%), Gaps = 60/296 (20%)

Query: 1800 SSFTFPLSGSSTSESLESSSKKNALASEIQGL------RTVEMKKGPTDSLGISIAGGV- 1852
            S++T  LS    +++ E   ++     E          R VE+ + P  SLGISI GG  
Sbjct: 1029 SAYTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQT 1088

Query: 1853 -------GSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905
                   G  L    IFI  +     A +T  L+ GD+I+ + G   +  +H++AV  +K
Sbjct: 1089 VIKRLKNGEELKG--IFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK 1146

Query: 1906 NASGSIEMQVVA-----------GGDVSVVTGHQQE---------------PASSSLSFT 1939
            NA   +   V +               + +TG+Q +               P      + 
Sbjct: 1147 NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYK 1206

Query: 1940 GLTSSS-------IFQD--------DLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLP 1984
             LT  S        F D        DL P +   I LE+  +GLG S+ G        + 
Sbjct: 1207 ALTDDSDENEEEDAFTDQKIRQRYADL-PGELHIIELEKDKNGLGLSLAGN--KDRSRMS 1263

Query: 1985 IYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
            I+V  +  +G A+ DGR++ GD+++ +N Q L G +H+ A AI+K     V L+ +
Sbjct: 1264 IFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI 1319



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 7/96 (7%)

Query: 1952 GPPQCKSITLERGPDGLGFSIVGGYGS----PHGD--LPIYVKTVFAKGAASEDGRLKRG 2005
            GPP+   I  E     LG SIVGG        +G+    I++K V     A +   LK G
Sbjct: 1064 GPPRIVEIFREPNVS-LGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTG 1122

Query: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVLS 2041
            D+I+ V+G  L+  +H EAV  +K     V  +V S
Sbjct: 1123 DKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQS 1158


>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
          Length = 690

 Score =  223 bits (568), Expect = 1e-57
 Identities = 168/513 (32%), Positives = 260/513 (50%), Gaps = 60/513 (11%)

Query: 1575 GAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISK 1634
            GA   E+  +S SL    + S EP         S  A     P + P   G  TTIEI +
Sbjct: 184  GAVPVERHLTSASL---STWSEEPGLDNPAFEESAGADTTQQPLSLP--EGEITTIEIHR 238

Query: 1635 GRT--GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
                  LG+SIVGG++T L  I+I EVY +G   +DGRL AGDQIL+VN  ++   +H+ 
Sbjct: 239  SNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNY 298

Query: 1693 AINVLRQTPQRVRLTLYRD-----------EAPYKEEEVCDTLTIELQKKP-GKGLGLSI 1740
            A  VL Q    + LT+ R+           ++    EE+     + L K+  G+ LG+ +
Sbjct: 299  ARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEI---FQVALHKRDSGEQLGIKL 355

Query: 1741 VGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLS 1800
            V + ++ GVF+ D+++GG+A  DGRL   D++L +NG D++  T E  A +++ S G   
Sbjct: 356  VRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQAS-GERV 414

Query: 1801 SFTFPLSG--------------SSTSES-------LESSSKKNALASEIQGLRTVEMKKG 1839
            + T    G              SS+S+           SS K+         + + +KK 
Sbjct: 415  NLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKE 474

Query: 1840 PTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQ 1899
            P +SLG+++AGG GS  G++PIF+  + P G  A+  +++ GD ++ I G     ++H++
Sbjct: 475  PHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSE 534

Query: 1900 AVNLLKNASGS-------IEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLG 1952
            AV +LK ++ S       +E+Q+V           +++P++ S +    + S  +   LG
Sbjct: 535  AVAMLKASAASPAVALKALEVQIVE----EATQNAEEQPSTFSENEYDASWSPSWVMWLG 590

Query: 1953 PPQ----CKSITLERGPDGL-GFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQ 2007
             P     C  I L R   G  GFSIVGGY   H + P ++KT+     A  DGRLK GD 
Sbjct: 591  LPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDM 650

Query: 2008 IIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
            I+AVNG S  G++H   V +LK  +  VTL V+
Sbjct: 651  IVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683



 Score =  119 bits (299), Expect = 2e-26
 Identities = 114/491 (23%), Positives = 190/491 (38%), Gaps = 101/491 (20%)

Query: 1483 HLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
            H   P  Q G+ I    E  L  ++I+ +   GV A DGRL  GDQIL V++  +     
Sbjct: 237  HRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSH 296

Query: 1543 EKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIR 1602
                ++L     T+ LT+  E        + + + S  ++    +L    SG  E   I+
Sbjct: 297  NYARAVLSQPCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSG--EQLGIK 354

Query: 1603 NTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEE 1662
               R+  P +F                                          I ++ E 
Sbjct: 355  LVRRTDEPGVF------------------------------------------ILDLLEG 372

Query: 1663 GAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV-- 1720
            G A +DGRL + D++L +NG DL+  T + A  +++ + +RV LT+ R   P     +  
Sbjct: 373  GLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGNTIRE 432

Query: 1721 -------------------------------CDTLTIELQKKPGKGLGLSIVG----KRN 1745
                                           C    I ++K+P + LG+++ G    K  
Sbjct: 433  AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSG 492

Query: 1746 DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGS----LSS 1801
            +  +FV+ +   G    DGR+ +GD +L +NG D+ N +     A+LK S  S    L +
Sbjct: 493  ELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKA 552

Query: 1802 FTFPLSGSSTSESLESSSKKN----------------ALASEIQGLRTVEMKKGPTDSLG 1845
                +   +T  + E  S  +                 L S +     + +++    S G
Sbjct: 553  LEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWG 612

Query: 1846 ISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905
             SI GG      + P FI  +     A    +L+ GD IV + G ST GM+H+  V +LK
Sbjct: 613  FSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLK 672

Query: 1906 NASGSIEMQVV 1916
                 + + V+
Sbjct: 673  EQRNKVTLTVI 683



 Score =  117 bits (294), Expect = 9e-26
 Identities = 127/490 (25%), Positives = 212/490 (43%), Gaps = 63/490 (12%)

Query: 148 LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAIS 207
           LG S+VG        + I +QE+    V  RDGRL   DQIL +N   +   ++H  A +
Sbjct: 245 LGISIVG--GNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISN-VSHNYARA 301

Query: 208 ILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGL 267
           +L +  +T+ L + R            R  + A   S  ++P        +   + G  L
Sbjct: 302 VLSQPCNTLHLTVLRER----------RFGNRAHNHSDSNSPREEIFQVALHKRDSGEQL 351

Query: 268 GFGIIGGK-ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG 326
           G  ++      GV +  +L GG+A Q GRL S D +L I   DL   + E  AQ+++  G
Sbjct: 352 GIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASG 411

Query: 327 NRVKLMIAR-GAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV- 384
            RV L IAR G  +        G   SSS   TP       +   + ++    +  K++ 
Sbjct: 412 ERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQ-EKHIT 470

Query: 385 ------QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
                 + LG+T+AG  G K  E   IFV S+     +  DGRI+ GD ++ ++G +L  
Sbjct: 471 VKKEPHESLGMTVAGGRGSKSGE-LPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529

Query: 439 FTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDE 498
            ++ +AV +L+ +  +  + L      +  E+   E+ T++A+  P   S   EN E D 
Sbjct: 530 LSHSEAVAMLKASAASPAVAL------KALEVQIVEEATQNAEEQP---STFSEN-EYDA 579

Query: 499 DFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSK 558
            +  S      LP          + +    D   + + L +    I+G            
Sbjct: 580 SWSPSWVMWLGLP----------STLHSCHDIVLRRSYLGSWGFSIVG------------ 617

Query: 559 FSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
                  G     T    FI++++   P  + G+L  GD ++ VNG++ +G +H  +V +
Sbjct: 618 -------GYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPM 670

Query: 619 LKELPIEVTM 628
           LKE   +VT+
Sbjct: 671 LKEQRNKVTL 680



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 173/717 (24%), Positives = 275/717 (38%), Gaps = 186/717 (25%)

Query: 879  SSPPKDVIENSCDPVLDLHMSLE---ELYTQNLLQRQDENTPSVDISMGPASGFTINDYT 935
            SS  KDV++  CD  L+ H+        + +  L+R+  +    +I     +G T+ D  
Sbjct: 117  SSVCKDVMQR-CD--LEAHLKNRCPGASHRRVALERRKTSRTQAEIEN--ENGPTLLD-- 169

Query: 936  PANAIEQQYECENT-IVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAEC 994
            PA  +  + +C  T  V  E HL S  +S+      L + A        E+S+ A   + 
Sbjct: 170  PAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNPA-------FEESAGADTTQ- 221

Query: 995  VMLQNVSKESFE-RTINIAKGNS--SLGMTVSANKDG--LGMIVRSIIHGGAISRDGRIA 1049
               Q +S    E  TI I + N    LG+++    +   + ++++ +   G I+RDGR+ 
Sbjct: 222  ---QPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLL 278

Query: 1050 IGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVM 1109
             GD IL +N  +  +V++  ARA+L +             P   L               
Sbjct: 279  AGDQILQVNNYNISNVSHNYARAVLSQ-------------PCNTLH-------------- 311

Query: 1110 ALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR----RVELWREPSKSLGIS 1165
                        +  L ER  G    +      +S+ N PR    +V L +  S      
Sbjct: 312  ------------LTVLRERRFGNRAHN------HSDSNSPREEIFQVALHKRDS------ 347

Query: 1166 IVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAV 1225
               G  +G +L       G+FI  +LE   A ++G L   DR++ ++G DL+  + E A 
Sbjct: 348  ---GEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAA 404

Query: 1226 EAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQS 1285
            + I+ +G      V   I RP K P P   + +    N SS+               SQ 
Sbjct: 405  QIIQASGE----RVNLTIARPGK-PQPG--NTIREAGNHSSS---------------SQH 442

Query: 1286 ESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLT 1345
             +           PPP  +      D TQ    +                          
Sbjct: 443  HT-----------PPPYYSRPSSHKDLTQCVTCQ-------------------------- 465

Query: 1346 GELHMIELEKGHSGLGLSLAGNK--DRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
             E H+   ++ H  LG+++AG +      + +F+  + P+G   +DGR++  D LL ING
Sbjct: 466  -EKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNING 524

Query: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSN--SENLQNKE 1461
              L   SH  A +++K +                  A  P  A++ L      E  QN E
Sbjct: 525  IDLTNLSHSEAVAMLKAS------------------AASPAVALKALEVQIVEEATQNAE 566

Query: 1462 TEPTVTTSDAAVDLS-SFKNVQHLELPKD-------------QGGLGIAI----SEEDTL 1503
             +P+ T S+   D S S   V  L LP                G  G +I     E  T 
Sbjct: 567  EQPS-TFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTN 625

Query: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
                IK++     A  DGRLK GD I+AV+    VG      + +LK  +  V LT+
Sbjct: 626  QPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 88/331 (26%), Positives = 145/331 (43%), Gaps = 40/331 (12%)

Query: 162 ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
           E G+F+ ++ EG +A +DGRL   D++LAING  L    T + A  I+Q + + V L IA
Sbjct: 361 EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYG-TPELAAQIIQASGERVNLTIA 419

Query: 222 RGSLPQLVSPIVSRSPSAASTISAHSNPVHW-----QHMETIELVN-----------DGS 265
           R   PQ  + I  R     S+ S H  P  +      H +  + V               
Sbjct: 420 RPGKPQPGNTI--REAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHE 477

Query: 266 GLGFGIIGGKATG-----VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
            LG  + GG+ +      + V ++ P G   + GR+  GD +L I   DL  +S  +   
Sbjct: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537

Query: 321 VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKG---------E 371
           +L+   +     +A  A+E +    A        P++  E   DAS              
Sbjct: 538 MLK--ASAASPAVALKALEVQIVEEATQ-NAEEQPSTFSENEYDASWSPSWVMWLGLPST 594

Query: 372 ESETFDVELTKNVQGL-GITIAG-YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
                D+ L ++  G  G +I G Y  +   +P   F+K+I   +   +DGR++ GD I+
Sbjct: 595 LHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQP--FFIKTIVLGTPAYYDGRLKCGDMIV 652

Query: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM 460
           AV+G +  G ++   V +L+     V LT++
Sbjct: 653 AVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 92/373 (24%), Positives = 158/373 (42%), Gaps = 37/373 (9%)

Query: 1347 ELHMIELEKGHSG--LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQ 1404
            E+  + L K  SG  LG+ L    D     VFI+ +   G A +DGRL   D +L ING 
Sbjct: 336  EIFQVALHKRDSGEQLGIKLVRRTDEP--GVFILDLLEGGLAAQDGRLSSNDRVLAINGH 393

Query: 1405 ILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEP 1464
             L   + + A+ II+ +  +V +   R           PGN +    ++S + Q+    P
Sbjct: 394  DLKYGTPELAAQIIQASGERVNLTIARPGKPQ------PGNTIREAGNHSSSSQHHTPPP 447

Query: 1465 TVTTSDAAVDLSSFKNVQ--HLELPKD-QGGLGIAIS-EEDTLSG---VIIKSLTEHGVA 1517
              +   +  DL+     Q  H+ + K+    LG+ ++    + SG   + + S+  HG  
Sbjct: 448  YYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCL 507

Query: 1518 ATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAA 1577
            A DGR+K GD +L ++   +      + +++LK +  +  + + A   + Q V  A   A
Sbjct: 508  ARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPAVALKA--LEVQIVEEATQNA 565

Query: 1578 SGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRT 1637
              +    S             E+  + S S +  ++   P+T   +  C   +       
Sbjct: 566  EEQPSTFS-------------ENEYDASWSPSWVMWLGLPST---LHSCHDIVLRRSYLG 609

Query: 1638 GLGLSIVGG--SDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAIN 1695
              G SIVGG   +       I  +     A  DGRL  GD I+ VNG+     +H   + 
Sbjct: 610  SWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVP 669

Query: 1696 VLRQTPQRVRLTL 1708
            +L++   +V LT+
Sbjct: 670  MLKEQRNKVTLTV 682



 Score = 74.7 bits (182), Expect = 9e-13
 Identities = 66/224 (29%), Positives = 95/224 (42%), Gaps = 27/224 (12%)

Query: 131 QGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILA 190
           Q +H+ V    K P   LG +V G R    GEL IFV  +       RDGR+K  D +L 
Sbjct: 465 QEKHITV---KKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLN 521

Query: 191 INGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPV 250
           ING  L   ++H +A+++L KA      V  +    Q+V      +    ST S +    
Sbjct: 522 INGIDL-TNLSHSEAVAML-KASAASPAVALKALEVQIVEEATQNAEEQPSTFSENEYDA 579

Query: 251 HWQHM--------ETIELVND--------GSGLGFGIIGGKATG-----VIVKTILPGGV 289
            W            T+   +D        GS  GF I+GG           +KTI+ G  
Sbjct: 580 SWSPSWVMWLGLPSTLHSCHDIVLRRSYLGS-WGFSIVGGYEENHTNQPFFIKTIVLGTP 638

Query: 290 ADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
           A   GRL  GD I+ +      GMS   +  +L++  N+V L +
Sbjct: 639 AYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTV 682



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 98/450 (21%), Positives = 171/450 (38%), Gaps = 122/450 (27%)

Query: 1002 KESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
            +E F+  ++       LG+ +    D  G+ +  ++ GG  ++DGR++  D +L+IN   
Sbjct: 335  EEIFQVALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAIN--- 391

Query: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121
                               G D+K          E    + Q SG  + L I  +  G+ 
Sbjct: 392  -------------------GHDLKY------GTPELAAQIIQASGERVNLTI--ARPGKP 424

Query: 1122 IPELPEREEGEGEESELQNTAYSNWNQP--------------RRVELWREPSKSLGISIV 1167
             P    RE G    S   +T    +++P              + + + +EP +SLG+++ 
Sbjct: 425  QPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVA 484

Query: 1168 GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEA 1227
            GGRG  S    GE+   IF+  V       ++G +K GD ++ ++G+DL + SH +AV  
Sbjct: 485  GGRGSKS----GEL--PIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAM 538

Query: 1228 IR-KAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSE 1286
            ++  A +P V +                                  +L++   +  +Q+ 
Sbjct: 539  LKASAASPAVAL---------------------------------KALEVQIVEEATQNA 565

Query: 1287 SEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTG 1346
             E             PS F+E                    +E+  SW      +  L  
Sbjct: 566  EE------------QPSTFSE--------------------NEYDASWSPSWVMWLGLPS 593

Query: 1347 ELHM---IELEKGHSG-LGLSLAG--NKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLE 1400
             LH    I L + + G  G S+ G   ++ +    FI  I     A  DGRL+  D ++ 
Sbjct: 594  TLHSCHDIVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVA 653

Query: 1401 INGQILYGRSHQNASSIIKCAPSKVKIIFI 1430
            +NG    G SH     ++K   +KV +  I
Sbjct: 654  VNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 35/123 (28%), Positives = 61/123 (49%), Gaps = 8/123 (6%)

Query: 667 SSETEDPVL--AMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSK--GLGFSILDYQDPID 722
           S+ +E+P L     +     +  Q PL++ E  I  IE+ + +    LG SI+   +   
Sbjct: 198 STWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNET-- 255

Query: 723 PASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIG 782
                I+I+ +   G+  +DGRLL GD+++ VN+ N+ N S   A  A+   P  T+ + 
Sbjct: 256 -PLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYA-RAVLSQPCNTLHLT 313

Query: 783 VAK 785
           V +
Sbjct: 314 VLR 316



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 56/232 (24%), Positives = 81/232 (34%), Gaps = 38/232 (16%)

Query: 552 VVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
           V  H     E  G+ +         FI  +L  G     G+L S D +L +NG  L    
Sbjct: 340 VALHKRDSGEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGT 399

Query: 612 HQDVVNILKELPIEVTMVCCR--RTVPPTTQSELDSLDLCDIELTEKP-------HVDLG 662
            +    I++     V +   R  +  P  T  E  +        T  P       H DL 
Sbjct: 400 PELAAQIIQASGERVNLTIARPGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLT 459

Query: 663 EFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPID 722
           + +   E    V          +E    L M  AG       +GSK              
Sbjct: 460 QCVTCQEKHITV---------KKEPHESLGMTVAG------GRGSKS------------- 491

Query: 723 PASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
                I + S+ P G   +DGR+  GD L+ +N ++L N S  EAV  LK +
Sbjct: 492 -GELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKAS 542



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 60/269 (22%), Positives = 106/269 (39%), Gaps = 60/269 (22%)

Query: 550 EIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
           EI    + + +    LGIS+    E  + +  I+ V  +G +   G+L +GD++L+VN  
Sbjct: 230 EITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNY 289

Query: 606 TLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFI 665
            +   +H     +L +              P  T           + LT       G   
Sbjct: 290 NISNVSHNYARAVLSQ--------------PCNT-----------LHLTVLRERRFGNRA 324

Query: 666 GSSETEDPVLAMTDAGQSTEEV-QAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPA 724
            +          +D+    EE+ Q  L   ++G Q          LG  ++   D  +P 
Sbjct: 325 HNH---------SDSNSPREEIFQVALHKRDSGEQ----------LGIKLVRRTD--EPG 363

Query: 725 STVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVA 784
              + I  L+ GG+A +DGRL   DR++ +N  +L+  + E A + ++ A    V + +A
Sbjct: 364 ---VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQ-ASGERVNLTIA 419

Query: 785 KPLPLSP-----EEGYVSAKEDSFLYPPH 808
           +P    P     E G  S+       PP+
Sbjct: 420 RPGKPQPGNTIREAGNHSSSSQHHTPPPY 448


>gi|187607085 ligand of numb-protein X 1 isoform a [Homo sapiens]
          Length = 728

 Score =  209 bits (533), Expect = 2e-53
 Identities = 152/488 (31%), Positives = 248/488 (50%), Gaps = 64/488 (13%)

Query: 1603 NTSRSSTPAIFASDPATCPIIPGCE-TTIEISKGRTGLGLSI--VGGSDTLLGAIIIHEV 1659
            N+  ++ P +F   P    +IP  E T+I+I++      LSI  VGGS+T L  III  +
Sbjct: 250  NSENTTAPEVF---PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHI 306

Query: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRD-------- 1711
            Y +G   +DGRL  GD IL+VNG+D+    H+ A+ +LRQ  Q + LT+ R+        
Sbjct: 307  YRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN 366

Query: 1712 -EAPYKEEEVCDTLTIELQK-KPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQG 1769
             +AP       D+  + L K  P + LG+ +V K ++ GVF+ +++ GG+A   G+L + 
Sbjct: 367  GQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEN 426

Query: 1770 DQILMVNGEDVRNATQEAVAALLKVSEGSL-----------SSFTFPLSGSSTSESL--- 1815
            D++L +NG D+R  + E+ A L++ SE  +           S   F  +G +++ S    
Sbjct: 427  DRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG 486

Query: 1816 --ESSSKKNALASEIQ-GLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVA 1872
              E S+    L   I    + V ++K P +SLG+++AGG      D+PI++  + P GV 
Sbjct: 487  PGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVI 546

Query: 1873 AQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPA 1932
            ++  +++ GD ++ + G     ++ ++AV LLK  S SI ++      + V     QE  
Sbjct: 547  SRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKA-----LEVKEYEPQEDC 601

Query: 1933 SSSLSFTGLTSSSIFQDDLGPP------------------QCKSITLERGPDG-LGFSIV 1973
            SS  +            ++ PP                   CK I L R   G LGF IV
Sbjct: 602  SSPAALDS-------NHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV 654

Query: 1974 GGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKG 2033
            GGY   +G+ P ++K++     A  DGR++ GD ++AVNG+S  G+ H     +LK  KG
Sbjct: 655  GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKG 714

Query: 2034 TVTLMVLS 2041
             +TL ++S
Sbjct: 715  RITLTIVS 722



 Score =  117 bits (294), Expect = 9e-26
 Identities = 117/518 (22%), Positives = 199/518 (38%), Gaps = 98/518 (18%)

Query: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLT 1512
            NSEN    E  P +       +++S K +  ++ P +   + +    E  L  +II+ + 
Sbjct: 250  NSENTTAPEVFPRLYHLIPDGEITSIK-INRVD-PSESLSIRLVGGSETPLVHIIIQHIY 307

Query: 1513 EHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPS 1572
              GV A DGRL  GD IL V+   +   P    + LL+     + LT+  E         
Sbjct: 308  RDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE--------- 358

Query: 1573 AAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
                   +K  S  +   P +  P  +S       S+P                      
Sbjct: 359  -------QKFRSRNNGQAPDAYRPRDDSFHVILNKSSP---------------------- 389

Query: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
                  LG+ +V   D     + I  V + G A + G+L   D++L +NG DLR  + + 
Sbjct: 390  ---EEQLGIKLVRKVDE--PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPES 444

Query: 1693 AINVLRQTPQRVRLTLYRD------------------------------EAPYKEEEVCD 1722
            A ++++ + +RV L + R                                 P      C 
Sbjct: 445  AAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCH 504

Query: 1723 TLTIELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
               + +QK PG+ LG+++ G    +  D  ++V  +  GG+   DGR+  GD +L V+G 
Sbjct: 505  EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 564

Query: 1779 DVRNATQEAVAALLKVSEGSLSSFTF------PLSGSSTSESLESSSKKN---------- 1822
            ++   ++    ALLK +  S+           P    S+  +L+S+              
Sbjct: 565  ELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWV 624

Query: 1823 ---ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
                L   +   + + +++    SLG  I GG     G+ P FI  +     A    ++R
Sbjct: 625  MWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIR 684

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVA 1917
             GD ++ + G ST GM H     LLK   G I + +V+
Sbjct: 685  CGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 722



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 85/328 (25%), Positives = 153/328 (46%), Gaps = 38/328 (11%)

Query: 162 ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
           E G+F+  + +G VA+R G+L+E D++LAING  L    + + A  ++Q ++  V LV++
Sbjct: 403 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHLVVS 461

Query: 222 RGSLPQLVSPIV------------SRSPSAASTISAHSNPVHWQHMETIELVND-GSGLG 268
           R    +  SP +            S  P   S      +P    H + + +  D G  LG
Sbjct: 462 RQVRQR--SPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLG 519

Query: 269 FGIIGGKA-----TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
             + GG +       + V ++ PGGV  + GR+ +GD +L +   +L  +S  +   +L+
Sbjct: 520 MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579

Query: 324 QCGNRVKLMIAR----GAIEERTAPTALGITLSSSPTS--TPELRVDASTQKGEESETFD 377
           +  + + L           E+ ++P AL    + +P S  +P   +     +   +   D
Sbjct: 580 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN-CKD 638

Query: 378 VELTKNVQG-LGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
           + L +N  G LG  I G    Y G+K       F+KSI + +   +DGRI+ GD ++AV+
Sbjct: 639 IVLRRNTAGSLGFCIVGGYEEYNGNKPF-----FIKSIVEGTPAYNDGRIRCGDILLAVN 693

Query: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLM 460
           G +  G  +     +L+     + LT++
Sbjct: 694 GRSTSGMIHACLARLLKELKGRITLTIV 721



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 90/362 (24%), Positives = 153/362 (42%), Gaps = 43/362 (11%)

Query: 144 PSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
           PS  L   +VG        + I +Q I    V  RDGRL   D IL +NG  +   + H 
Sbjct: 282 PSESLSIRLVG--GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN-VPHN 338

Query: 204 QAISILQKAKDTVQLVIAR---------GSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
            A+ +L++    + L + R         G  P    P       +   I   S+P     
Sbjct: 339 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRP----RDDSFHVILNKSSPEEQLG 394

Query: 255 METIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
           ++ +  V++              GV +  +L GGVA +HG+L   D +L I   DL   S
Sbjct: 395 IKLVRKVDE-------------PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 441

Query: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
            E  A +++    RV L+++R  + +R+         +S+ + +P     ++T K     
Sbjct: 442 PESAAHLIQASERRVHLVVSR-QVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPT 500

Query: 375 TFDVELTKNVQ-----GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
               E   N+Q      LG+T+AG    ++ +   I+V S+     +  DGRI+ GD ++
Sbjct: 501 ITCHEKVVNIQKDPGESLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILL 559

Query: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM-------RRGMKQEAELMSREDVTKDADL 482
            VDG  L   +  +AV +L+ T  +++L  +       +      A L S  ++   +D 
Sbjct: 560 NVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDW 619

Query: 483 SP 484
           SP
Sbjct: 620 SP 621



 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 113/499 (22%), Positives = 199/499 (39%), Gaps = 95/499 (19%)

Query: 1346 GELHMIELEK--GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            GE+  I++ +      L + L G  +   + + I  I  +G   +DGRL   D +L++NG
Sbjct: 270  GEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNG 329

Query: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
              +    H  A  +++     + +  +R +   ++      +A  P   +   + NK + 
Sbjct: 330  MDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSS- 388

Query: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRL 1523
                                   P++Q  LGI +  +    GV I ++ + GVA   G+L
Sbjct: 389  -----------------------PEEQ--LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQL 423

Query: 1524 KVGDQILAVD-DEIVVGYPIEKFISLLKTAKMTVKLTIHAE-NPDSQAVPSAAGAASGEK 1581
            +  D++LA++  ++  G P E    L++ ++  V L +  +    S  +   AG  S   
Sbjct: 424  EENDRVLAINGHDLRYGSP-ESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN-- 480

Query: 1582 KNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKG-RTGLG 1640
                       S SP P    NT +   P I      TC      E  + I K     LG
Sbjct: 481  ----------GSWSPGPGERSNTPKPLHPTI------TCH-----EKVVNIQKDPGESLG 519

Query: 1641 LSIVGGSDTLLGAIIIHEVYEE--GAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLR 1698
            +++ GG+      + I+ +  E  G   +DGR+  GD +L V+G++L + +  EA+ +L+
Sbjct: 520  MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 579

Query: 1699 QTPQRVRLTLYRDEAPYKEEEVCDT---------------------------------LT 1725
            +T   + L    +   Y+ +E C +                                   
Sbjct: 580  RTSSSIVLKAL-EVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKD 638

Query: 1726 IELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
            I L++     LG  IVG       +   F+  IV+G  A  DGR+  GD +L VNG    
Sbjct: 639  IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 698

Query: 1782 NATQEAVAALLKVSEGSLS 1800
                  +A LLK  +G ++
Sbjct: 699  GMIHACLARLLKELKGRIT 717



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 87/362 (24%), Positives = 143/362 (39%), Gaps = 47/362 (12%)

Query: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
            LG+ L    D     VFI  +   G A + G+L+  D +L ING  L   S ++A+ +I+
Sbjct: 393  LGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 450

Query: 1420 CAPSKVKIIFI-----RNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
             +  +V ++       R+ D   +       +  P P    N   K   PT+T  +  V+
Sbjct: 451  ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP-KPLHPTITCHEKVVN 509

Query: 1475 LSSFKNVQHLELPKDQG-GLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQI 1529
            +            KD G  LG+ +    S  +    + + S+   GV + DGR+K GD +
Sbjct: 510  IQ-----------KDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDIL 558

Query: 1530 LAVDDEIVVGYPIEKFISLLK-TAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL 1588
            L VD   +      + ++LLK T+   V   +  +  + Q   S+  A      +S+ ++
Sbjct: 559  LNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAAL-----DSNHNM 613

Query: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
              P   SP         R                +  C+  +        LG  IVGG +
Sbjct: 614  APPSDWSPSWVMWLELPR---------------CLYNCKDIVLRRNTAGSLGFCIVGGYE 658

Query: 1649 TLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
               G     I  + E   A  DGR+  GD +L VNG       H     +L++   R+ L
Sbjct: 659  EYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718

Query: 1707 TL 1708
            T+
Sbjct: 719  TI 720



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 55/220 (25%), Positives = 98/220 (44%), Gaps = 23/220 (10%)

Query: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
           H +V  + K P   LG +V G  S    +L I+V  ++ G V  RDGR+K  D +L ++G
Sbjct: 504 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 563

Query: 194 QALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQ 253
             L + ++  +A+++L++   ++  V+    + +        SP+A  +    + P  W 
Sbjct: 564 VELTE-VSRSEAVALLKRTSSSI--VLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWS 620

Query: 254 HMETIELV---------------NDGSGLGFGIIGGKA-----TGVIVKTILPGGVADQH 293
               + L                N    LGF I+GG           +K+I+ G  A   
Sbjct: 621 PSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYND 680

Query: 294 GRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
           GR+  GD +L +     +GM    +A++L++   R+ L I
Sbjct: 681 GRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 103/537 (19%), Positives = 205/537 (38%), Gaps = 108/537 (20%)

Query: 258 IELVNDGSGLGFGIIGGKATG---VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
           I  V+    L   ++GG  T    +I++ I   GV  + GRL  GD ILK+   D++ + 
Sbjct: 277 INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP 336

Query: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
                ++LRQ    + L + R   E++      G                A        +
Sbjct: 337 HNYAVRLLRQPCQVLWLTVMR---EQKFRSRNNG---------------QAPDAYRPRDD 378

Query: 375 TFDVELTKNV--QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
           +F V L K+   + LGI +      +K++  G+F+ ++         G+++  D+++A++
Sbjct: 379 SFHVILNKSSPEEQLGIKLV-----RKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAIN 433

Query: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKE 492
           G +L+  + + A  +++ + + V L + R+  ++  ++        +   SP        
Sbjct: 434 GHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG------- 486

Query: 493 NYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIV 552
                             P E    P             K     +T  ++++ I  +  
Sbjct: 487 ------------------PGERSNTP-------------KPLHPTITCHEKVVNIQKD-- 513

Query: 553 VAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
                       LG+++     H       ++ SV P G +   G++ +GD LL V+G+ 
Sbjct: 514 --------PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVE 565

Query: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
           L   +  + V +LK     +                L +L++ + E    P  D      
Sbjct: 566 LTEVSRSEAVALLKRTSSSIV---------------LKALEVKEYE----PQEDCSSPAA 606

Query: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKG-LGFSILDYQDPIDPAS 725
                +       +      ++ P  ++    + I L + + G LGF I+   +  +  +
Sbjct: 607 LDSNHNMAPPSDWSPSWVMWLELPRCLYNC--KDIVLRRNTAGSLGFCIVGGYEEYN-GN 663

Query: 726 TVIIIRSLVPGGIAEKDGRLLPGDRLMFVN---DVNLENSSLEEAVEALKGAPSGTV 779
               I+S+V G  A  DGR+  GD L+ VN      + ++ L   ++ LKG  + T+
Sbjct: 664 KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 63/241 (26%), Positives = 105/241 (43%), Gaps = 28/241 (11%)

Query: 1006 ERTINIAKG-NSSLGMTVSANKD----GLGMIVRSIIHGGAISRDGRIAIGDCILSINEE 1060
            E+ +NI K    SLGMTV+         L + V S+  GG ISRDGRI  GD +L+++  
Sbjct: 505  EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 564

Query: 1061 STISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGR 1120
                V+ ++A A+L+R S        + +  + LE  +    +      ALD     +  
Sbjct: 565  ELTEVSRSEAVALLKRTS--------SSIVLKALEVKEYEPQEDCSSPAALD-----SNH 611

Query: 1121 DIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGE 1180
            ++    +         EL    Y+     + + L R  + SLG  IVG    G    NG 
Sbjct: 612  NMAPPSDWSPSWVMWLELPRCLYN----CKDIVLRRNTAGSLGFCIVG----GYEEYNGN 663

Query: 1181 VMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
              +  FIK ++E +PA  +G ++ GD ++ V+G       H      +++    +   + 
Sbjct: 664  --KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 721

Query: 1241 S 1241
            S
Sbjct: 722  S 722



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 83/431 (19%), Positives = 160/431 (37%), Gaps = 90/431 (20%)

Query: 1003 ESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            +SF   +N +     LG+ +    D  G+ + +++ GG   R G++   D +L+IN    
Sbjct: 378  DSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHD- 436

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
            +   + ++ A    H +   + ++  V +  + +    + Q++G         +  G   
Sbjct: 437  LRYGSPESAA----HLIQASERRVHLVVSRQVRQRSPDIFQEAG--------WNSNGSWS 484

Query: 1123 PELPEREEGEGEESELQNTAYSNWN-QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
            P       G GE S      +       + V + ++P +SLG+++ GG       S+ E 
Sbjct: 485  P-------GPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGG------ASHREW 531

Query: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS 1241
               I++  V       ++G +K GD ++ VDG++L + S  +AV  +++  + +V     
Sbjct: 532  DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL---- 587

Query: 1242 IINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPP 1301
                                                  KA    E EP++   CS P   
Sbjct: 588  --------------------------------------KALEVKEYEPQED--CSSP--- 604

Query: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361
                A + S+H  +  S          ++  SW    E    L     ++        LG
Sbjct: 605  ----AALDSNHNMAPPS----------DWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLG 650

Query: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
              + G  +        FI  I     A  DGR++  D LL +NG+   G  H   + ++K
Sbjct: 651  FCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLK 710

Query: 1420 CAPSKVKIIFI 1430
                ++ +  +
Sbjct: 711  ELKGRITLTIV 721



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 13/217 (5%)

Query: 1351 IELEKGHSGLGLSLAGNKDRSR--MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
            I+ + G S LG+++AG        + ++++ ++P G   +DGR++  D LL ++G  L  
Sbjct: 510  IQKDPGES-LGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTE 568

Query: 1409 RSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPT-VT 1467
             S   A +++K   S + +  +  K+   Q   C   A   L SN       +  P+ V 
Sbjct: 569  VSRSEAVALLKRTSSSIVLKALEVKEYEPQ-EDCSSPAA--LDSNHNMAPPSDWSPSWVM 625

Query: 1468 TSDAAVDLSSFKNVQHLELPKDQGGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRL 1523
              +    L + K++  +      G LG  I     E +      IKS+ E   A  DGR+
Sbjct: 626  WLELPRCLYNCKDI--VLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 683

Query: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
            + GD +LAV+     G        LLK  K  + LTI
Sbjct: 684  RCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 720



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 26/74 (35%), Positives = 42/74 (56%), Gaps = 8/74 (10%)

Query: 1157 EPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
            +PS+SL I +VGG        +   +  I I+H+  D    ++G L PGD I++V+GMD+
Sbjct: 281  DPSESLSIRLVGG--------SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 332

Query: 1217 RDASHEQAVEAIRK 1230
             +  H  AV  +R+
Sbjct: 333  SNVPHNYAVRLLRQ 346



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 51/210 (24%)

Query: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVP 1090
            +I++ I   G I+RDGR+  GD IL +N                         + I+ VP
Sbjct: 301  IIIQHIYRDGVIARDGRLLPGDIILKVN------------------------GMDISNVP 336

Query: 1091 AEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR 1150
                  + + L +Q  +V+ L +      R       R  G+  +      AY   +   
Sbjct: 337  ----HNYAVRLLRQPCQVLWLTVMREQKFRS------RNNGQAPD------AYRPRDDSF 380

Query: 1151 RVELWRE-PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
             V L +  P + LGI +V  R +           G+FI +VL+   A ++G L+  DR++
Sbjct: 381  HVILNKSSPEEQLGIKLV--RKVDEP--------GVFIFNVLDGGVAYRHGQLEENDRVL 430

Query: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
             ++G DLR  S E A   I+ +   V  +V
Sbjct: 431  AINGHDLRYGSPESAAHLIQASERRVHLVV 460



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 5/88 (5%)

Query: 550 EIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
           EI    +++   +  L I L    E  + H  I+ +  +G +   G+L  GD +L+VNG+
Sbjct: 271 EITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGM 330

Query: 606 TLLGENHQDVVNILKELPIEVTMVCCRR 633
            +    H   V +L++ P +V  +   R
Sbjct: 331 DISNVPHNYAVRLLRQ-PCQVLWLTVMR 357


>gi|187607071 ligand of numb-protein X 1 isoform b [Homo sapiens]
          Length = 632

 Score =  209 bits (533), Expect = 2e-53
 Identities = 152/488 (31%), Positives = 248/488 (50%), Gaps = 64/488 (13%)

Query: 1603 NTSRSSTPAIFASDPATCPIIPGCE-TTIEISKGRTGLGLSI--VGGSDTLLGAIIIHEV 1659
            N+  ++ P +F   P    +IP  E T+I+I++      LSI  VGGS+T L  III  +
Sbjct: 154  NSENTTAPEVF---PRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHI 210

Query: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRD-------- 1711
            Y +G   +DGRL  GD IL+VNG+D+    H+ A+ +LRQ  Q + LT+ R+        
Sbjct: 211  YRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNN 270

Query: 1712 -EAPYKEEEVCDTLTIELQK-KPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQG 1769
             +AP       D+  + L K  P + LG+ +V K ++ GVF+ +++ GG+A   G+L + 
Sbjct: 271  GQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEEN 330

Query: 1770 DQILMVNGEDVRNATQEAVAALLKVSEGSL-----------SSFTFPLSGSSTSESL--- 1815
            D++L +NG D+R  + E+ A L++ SE  +           S   F  +G +++ S    
Sbjct: 331  DRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG 390

Query: 1816 --ESSSKKNALASEIQ-GLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVA 1872
              E S+    L   I    + V ++K P +SLG+++AGG      D+PI++  + P GV 
Sbjct: 391  PGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVI 450

Query: 1873 AQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPA 1932
            ++  +++ GD ++ + G     ++ ++AV LLK  S SI ++      + V     QE  
Sbjct: 451  SRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKA-----LEVKEYEPQEDC 505

Query: 1933 SSSLSFTGLTSSSIFQDDLGPP------------------QCKSITLERGPDG-LGFSIV 1973
            SS  +            ++ PP                   CK I L R   G LGF IV
Sbjct: 506  SSPAALDS-------NHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIV 558

Query: 1974 GGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKG 2033
            GGY   +G+ P ++K++     A  DGR++ GD ++AVNG+S  G+ H     +LK  KG
Sbjct: 559  GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKG 618

Query: 2034 TVTLMVLS 2041
             +TL ++S
Sbjct: 619  RITLTIVS 626



 Score =  117 bits (294), Expect = 9e-26
 Identities = 117/518 (22%), Positives = 199/518 (38%), Gaps = 98/518 (18%)

Query: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLT 1512
            NSEN    E  P +       +++S K +  ++ P +   + +    E  L  +II+ + 
Sbjct: 154  NSENTTAPEVFPRLYHLIPDGEITSIK-INRVD-PSESLSIRLVGGSETPLVHIIIQHIY 211

Query: 1513 EHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPS 1572
              GV A DGRL  GD IL V+   +   P    + LL+     + LT+  E         
Sbjct: 212  RDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMRE--------- 262

Query: 1573 AAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEI 1632
                   +K  S  +   P +  P  +S       S+P                      
Sbjct: 263  -------QKFRSRNNGQAPDAYRPRDDSFHVILNKSSP---------------------- 293

Query: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
                  LG+ +V   D     + I  V + G A + G+L   D++L +NG DLR  + + 
Sbjct: 294  ---EEQLGIKLVRKVDE--PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPES 348

Query: 1693 AINVLRQTPQRVRLTLYRD------------------------------EAPYKEEEVCD 1722
            A ++++ + +RV L + R                                 P      C 
Sbjct: 349  AAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCH 408

Query: 1723 TLTIELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
               + +QK PG+ LG+++ G    +  D  ++V  +  GG+   DGR+  GD +L V+G 
Sbjct: 409  EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 468

Query: 1779 DVRNATQEAVAALLKVSEGSLSSFTF------PLSGSSTSESLESSSKKN---------- 1822
            ++   ++    ALLK +  S+           P    S+  +L+S+              
Sbjct: 469  ELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWV 528

Query: 1823 ---ALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
                L   +   + + +++    SLG  I GG     G+ P FI  +     A    ++R
Sbjct: 529  MWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIR 588

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVA 1917
             GD ++ + G ST GM H     LLK   G I + +V+
Sbjct: 589  CGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVS 626



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 85/328 (25%), Positives = 153/328 (46%), Gaps = 38/328 (11%)

Query: 162 ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
           E G+F+  + +G VA+R G+L+E D++LAING  L    + + A  ++Q ++  V LV++
Sbjct: 307 EPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYG-SPESAAHLIQASERRVHLVVS 365

Query: 222 RGSLPQLVSPIV------------SRSPSAASTISAHSNPVHWQHMETIELVND-GSGLG 268
           R    +  SP +            S  P   S      +P    H + + +  D G  LG
Sbjct: 366 RQVRQR--SPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLG 423

Query: 269 FGIIGGKA-----TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
             + GG +       + V ++ PGGV  + GR+ +GD +L +   +L  +S  +   +L+
Sbjct: 424 MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483

Query: 324 QCGNRVKLMIAR----GAIEERTAPTALGITLSSSPTS--TPELRVDASTQKGEESETFD 377
           +  + + L           E+ ++P AL    + +P S  +P   +     +   +   D
Sbjct: 484 RTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYN-CKD 542

Query: 378 VELTKNVQG-LGITIAG----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
           + L +N  G LG  I G    Y G+K       F+KSI + +   +DGRI+ GD ++AV+
Sbjct: 543 IVLRRNTAGSLGFCIVGGYEEYNGNKPF-----FIKSIVEGTPAYNDGRIRCGDILLAVN 597

Query: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLM 460
           G +  G  +     +L+     + LT++
Sbjct: 598 GRSTSGMIHACLARLLKELKGRITLTIV 625



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 90/362 (24%), Positives = 153/362 (42%), Gaps = 43/362 (11%)

Query: 144 PSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
           PS  L   +VG        + I +Q I    V  RDGRL   D IL +NG  +   + H 
Sbjct: 186 PSESLSIRLVG--GSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN-VPHN 242

Query: 204 QAISILQKAKDTVQLVIAR---------GSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
            A+ +L++    + L + R         G  P    P       +   I   S+P     
Sbjct: 243 YAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRP----RDDSFHVILNKSSPEEQLG 298

Query: 255 METIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
           ++ +  V++              GV +  +L GGVA +HG+L   D +L I   DL   S
Sbjct: 299 IKLVRKVDE-------------PGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGS 345

Query: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
            E  A +++    RV L+++R  + +R+         +S+ + +P     ++T K     
Sbjct: 346 PESAAHLIQASERRVHLVVSR-QVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPT 404

Query: 375 TFDVELTKNVQ-----GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
               E   N+Q      LG+T+AG    ++ +   I+V S+     +  DGRI+ GD ++
Sbjct: 405 ITCHEKVVNIQKDPGESLGMTVAGGASHREWD-LPIYVISVEPGGVISRDGRIKTGDILL 463

Query: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLM-------RRGMKQEAELMSREDVTKDADL 482
            VDG  L   +  +AV +L+ T  +++L  +       +      A L S  ++   +D 
Sbjct: 464 NVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDW 523

Query: 483 SP 484
           SP
Sbjct: 524 SP 525



 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 113/499 (22%), Positives = 199/499 (39%), Gaps = 95/499 (19%)

Query: 1346 GELHMIELEK--GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            GE+  I++ +      L + L G  +   + + I  I  +G   +DGRL   D +L++NG
Sbjct: 174  GEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNG 233

Query: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
              +    H  A  +++     + +  +R +   ++      +A  P   +   + NK + 
Sbjct: 234  MDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSS- 292

Query: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRL 1523
                                   P++Q  LGI +  +    GV I ++ + GVA   G+L
Sbjct: 293  -----------------------PEEQ--LGIKLVRKVDEPGVFIFNVLDGGVAYRHGQL 327

Query: 1524 KVGDQILAVD-DEIVVGYPIEKFISLLKTAKMTVKLTIHAE-NPDSQAVPSAAGAASGEK 1581
            +  D++LA++  ++  G P E    L++ ++  V L +  +    S  +   AG  S   
Sbjct: 328  EENDRVLAINGHDLRYGSP-ESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSN-- 384

Query: 1582 KNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKG-RTGLG 1640
                       S SP P    NT +   P I      TC      E  + I K     LG
Sbjct: 385  ----------GSWSPGPGERSNTPKPLHPTI------TCH-----EKVVNIQKDPGESLG 423

Query: 1641 LSIVGGSDTLLGAIIIHEVYEE--GAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLR 1698
            +++ GG+      + I+ +  E  G   +DGR+  GD +L V+G++L + +  EA+ +L+
Sbjct: 424  MTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLK 483

Query: 1699 QTPQRVRLTLYRDEAPYKEEEVCDT---------------------------------LT 1725
            +T   + L    +   Y+ +E C +                                   
Sbjct: 484  RTSSSIVLKAL-EVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKD 542

Query: 1726 IELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
            I L++     LG  IVG       +   F+  IV+G  A  DGR+  GD +L VNG    
Sbjct: 543  IVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTS 602

Query: 1782 NATQEAVAALLKVSEGSLS 1800
                  +A LLK  +G ++
Sbjct: 603  GMIHACLARLLKELKGRIT 621



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 87/362 (24%), Positives = 143/362 (39%), Gaps = 47/362 (12%)

Query: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
            LG+ L    D     VFI  +   G A + G+L+  D +L ING  L   S ++A+ +I+
Sbjct: 297  LGIKLVRKVDEP--GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQ 354

Query: 1420 CAPSKVKIIFI-----RNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
             +  +V ++       R+ D   +       +  P P    N   K   PT+T  +  V+
Sbjct: 355  ASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTP-KPLHPTITCHEKVVN 413

Query: 1475 LSSFKNVQHLELPKDQG-GLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQI 1529
            +            KD G  LG+ +    S  +    + + S+   GV + DGR+K GD +
Sbjct: 414  IQ-----------KDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDIL 462

Query: 1530 LAVDDEIVVGYPIEKFISLLK-TAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL 1588
            L VD   +      + ++LLK T+   V   +  +  + Q   S+  A      +S+ ++
Sbjct: 463  LNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAAL-----DSNHNM 517

Query: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
              P   SP         R                +  C+  +        LG  IVGG +
Sbjct: 518  APPSDWSPSWVMWLELPR---------------CLYNCKDIVLRRNTAGSLGFCIVGGYE 562

Query: 1649 TLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
               G     I  + E   A  DGR+  GD +L VNG       H     +L++   R+ L
Sbjct: 563  EYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 622

Query: 1707 TL 1708
            T+
Sbjct: 623  TI 624



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 55/220 (25%), Positives = 98/220 (44%), Gaps = 23/220 (10%)

Query: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193
           H +V  + K P   LG +V G  S    +L I+V  ++ G V  RDGR+K  D +L ++G
Sbjct: 408 HEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDG 467

Query: 194 QALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQ 253
             L + ++  +A+++L++   ++  V+    + +        SP+A  +    + P  W 
Sbjct: 468 VELTE-VSRSEAVALLKRTSSSI--VLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWS 524

Query: 254 HMETIELV---------------NDGSGLGFGIIGGKA-----TGVIVKTILPGGVADQH 293
               + L                N    LGF I+GG           +K+I+ G  A   
Sbjct: 525 PSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYND 584

Query: 294 GRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
           GR+  GD +L +     +GM    +A++L++   R+ L I
Sbjct: 585 GRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 103/537 (19%), Positives = 205/537 (38%), Gaps = 108/537 (20%)

Query: 258 IELVNDGSGLGFGIIGGKATG---VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
           I  V+    L   ++GG  T    +I++ I   GV  + GRL  GD ILK+   D++ + 
Sbjct: 181 INRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVP 240

Query: 315 SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESE 374
                ++LRQ    + L + R   E++      G                A        +
Sbjct: 241 HNYAVRLLRQPCQVLWLTVMR---EQKFRSRNNG---------------QAPDAYRPRDD 282

Query: 375 TFDVELTKNV--QGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVD 432
           +F V L K+   + LGI +      +K++  G+F+ ++         G+++  D+++A++
Sbjct: 283 SFHVILNKSSPEEQLGIKLV-----RKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAIN 337

Query: 433 GTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKE 492
           G +L+  + + A  +++ + + V L + R+  ++  ++        +   SP        
Sbjct: 338 GHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPG------- 390

Query: 493 NYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIV 552
                             P E    P             K     +T  ++++ I  +  
Sbjct: 391 ------------------PGERSNTP-------------KPLHPTITCHEKVVNIQKD-- 417

Query: 553 VAHVSKFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
                       LG+++     H       ++ SV P G +   G++ +GD LL V+G+ 
Sbjct: 418 --------PGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVE 469

Query: 607 LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
           L   +  + V +LK     +                L +L++ + E    P  D      
Sbjct: 470 LTEVSRSEAVALLKRTSSSIV---------------LKALEVKEYE----PQEDCSSPAA 510

Query: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKG-LGFSILDYQDPIDPAS 725
                +       +      ++ P  ++    + I L + + G LGF I+   +  +  +
Sbjct: 511 LDSNHNMAPPSDWSPSWVMWLELPRCLYNC--KDIVLRRNTAGSLGFCIVGGYEEYN-GN 567

Query: 726 TVIIIRSLVPGGIAEKDGRLLPGDRLMFVN---DVNLENSSLEEAVEALKGAPSGTV 779
               I+S+V G  A  DGR+  GD L+ VN      + ++ L   ++ LKG  + T+
Sbjct: 568 KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 63/241 (26%), Positives = 105/241 (43%), Gaps = 28/241 (11%)

Query: 1006 ERTINIAKG-NSSLGMTVSANKD----GLGMIVRSIIHGGAISRDGRIAIGDCILSINEE 1060
            E+ +NI K    SLGMTV+         L + V S+  GG ISRDGRI  GD +L+++  
Sbjct: 409  EKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGV 468

Query: 1061 STISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGR 1120
                V+ ++A A+L+R S        + +  + LE  +    +      ALD     +  
Sbjct: 469  ELTEVSRSEAVALLKRTS--------SSIVLKALEVKEYEPQEDCSSPAALD-----SNH 515

Query: 1121 DIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGE 1180
            ++    +         EL    Y+     + + L R  + SLG  IVG    G    NG 
Sbjct: 516  NMAPPSDWSPSWVMWLELPRCLYN----CKDIVLRRNTAGSLGFCIVG----GYEEYNGN 567

Query: 1181 VMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
              +  FIK ++E +PA  +G ++ GD ++ V+G       H      +++    +   + 
Sbjct: 568  --KPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIV 625

Query: 1241 S 1241
            S
Sbjct: 626  S 626



 Score = 59.3 bits (142), Expect = 4e-08
 Identities = 83/431 (19%), Positives = 160/431 (37%), Gaps = 90/431 (20%)

Query: 1003 ESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            +SF   +N +     LG+ +    D  G+ + +++ GG   R G++   D +L+IN    
Sbjct: 282  DSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHD- 340

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
            +   + ++ A    H +   + ++  V +  + +    + Q++G         +  G   
Sbjct: 341  LRYGSPESAA----HLIQASERRVHLVVSRQVRQRSPDIFQEAG--------WNSNGSWS 388

Query: 1123 PELPEREEGEGEESELQNTAYSNWN-QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
            P       G GE S      +       + V + ++P +SLG+++ GG       S+ E 
Sbjct: 389  P-------GPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGG------ASHREW 435

Query: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS 1241
               I++  V       ++G +K GD ++ VDG++L + S  +AV  +++  + +V     
Sbjct: 436  DLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVL---- 491

Query: 1242 IINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPP 1301
                                                  KA    E EP++   CS P   
Sbjct: 492  --------------------------------------KALEVKEYEPQED--CSSP--- 508

Query: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLG 1361
                A + S+H  +  S          ++  SW    E    L     ++        LG
Sbjct: 509  ----AALDSNHNMAPPS----------DWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLG 554

Query: 1362 LSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIK 1419
              + G  +        FI  I     A  DGR++  D LL +NG+   G  H   + ++K
Sbjct: 555  FCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLK 614

Query: 1420 CAPSKVKIIFI 1430
                ++ +  +
Sbjct: 615  ELKGRITLTIV 625



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 13/217 (5%)

Query: 1351 IELEKGHSGLGLSLAGNKDRSR--MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
            I+ + G S LG+++AG        + ++++ ++P G   +DGR++  D LL ++G  L  
Sbjct: 414  IQKDPGES-LGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTE 472

Query: 1409 RSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPT-VT 1467
             S   A +++K   S + +  +  K+   Q   C   A   L SN       +  P+ V 
Sbjct: 473  VSRSEAVALLKRTSSSIVLKALEVKEYEPQ-EDCSSPAA--LDSNHNMAPPSDWSPSWVM 529

Query: 1468 TSDAAVDLSSFKNVQHLELPKDQGGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRL 1523
              +    L + K++  +      G LG  I     E +      IKS+ E   A  DGR+
Sbjct: 530  WLELPRCLYNCKDI--VLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRI 587

Query: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
            + GD +LAV+     G        LLK  K  + LTI
Sbjct: 588  RCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTI 624



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 26/74 (35%), Positives = 42/74 (56%), Gaps = 8/74 (10%)

Query: 1157 EPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
            +PS+SL I +VGG        +   +  I I+H+  D    ++G L PGD I++V+GMD+
Sbjct: 185  DPSESLSIRLVGG--------SETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDI 236

Query: 1217 RDASHEQAVEAIRK 1230
             +  H  AV  +R+
Sbjct: 237  SNVPHNYAVRLLRQ 250



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 53/210 (25%), Positives = 87/210 (41%), Gaps = 51/210 (24%)

Query: 1031 MIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVP 1090
            +I++ I   G I+RDGR+  GD IL +N                         + I+ VP
Sbjct: 205  IIIQHIYRDGVIARDGRLLPGDIILKVN------------------------GMDISNVP 240

Query: 1091 AEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPR 1150
                  + + L +Q  +V+ L +      R       R  G+  +      AY   +   
Sbjct: 241  ----HNYAVRLLRQPCQVLWLTVMREQKFRS------RNNGQAPD------AYRPRDDSF 284

Query: 1151 RVELWRE-PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
             V L +  P + LGI +V  R +           G+FI +VL+   A ++G L+  DR++
Sbjct: 285  HVILNKSSPEEQLGIKLV--RKVDEP--------GVFIFNVLDGGVAYRHGQLEENDRVL 334

Query: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
             ++G DLR  S E A   I+ +   V  +V
Sbjct: 335  AINGHDLRYGSPESAAHLIQASERRVHLVV 364



 Score = 37.4 bits (85), Expect = 0.15
 Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 5/88 (5%)

Query: 550 EIVVAHVSKFSENSGLGISL----EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
           EI    +++   +  L I L    E  + H  I+ +  +G +   G+L  GD +L+VNG+
Sbjct: 175 EITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGM 234

Query: 606 TLLGENHQDVVNILKELPIEVTMVCCRR 633
            +    H   V +L++ P +V  +   R
Sbjct: 235 DISNVPHNYAVRLLRQ-PCQVLWLTVMR 261


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score =  150 bits (379), Expect = 1e-35
 Identities = 147/497 (29%), Positives = 215/497 (43%), Gaps = 118/497 (23%)

Query: 1627 ETTIEISKGRTGLGLSIVGGSDTLL-----GAIIIHEVYEEGAACKDGRLWAGDQILEVN 1681
            E T+ I +   GLG+SI GG  +         I I  V EEG A + G +  GD++LEVN
Sbjct: 726  ELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVN 784

Query: 1682 GIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT------------------ 1723
            G+ L+ A H EA+  LR     V++ ++R+     E  V  T                  
Sbjct: 785  GVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGL 844

Query: 1724 -LTIELQKKPG--------------KGLGLSIVG-------KRNDTGVFVSDIVKGGIAD 1761
             L +   + PG              +GLG SI G       +  D G+FVS I +GG A 
Sbjct: 845  RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904

Query: 1762 ADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE------------GSLSSFTFPLSGS 1809
              G L  GD++L +NG DV  A  +   +LL  +             G L     P S  
Sbjct: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964

Query: 1810 STSESLES-------------SSKKNALASEIQGLRTVEMKKGPT--DSLGISIAGG--- 1851
             T+    +             S   + LA+ ++G   VE  + P     LG+SI GG   
Sbjct: 965  PTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDH 1024

Query: 1852 VGSPLG--DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG 1909
               P G  +  +FI+ + P G+AA++  LRVGDRI+ + G      TH +AV        
Sbjct: 1025 SSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNGQDVRDATHQEAV-------- 1075

Query: 1910 SIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGP-DGL 1968
                                    S+L    L  S + + D  PP  + + +++ P + L
Sbjct: 1076 ------------------------SALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERL 1111

Query: 1969 GFSIVGG----YGSPHG--DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2022
            G SI GG     G+P    D  I++  V   GAA  DGRL+ G +++ VN QSL G+TH 
Sbjct: 1112 GISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHG 1171

Query: 2023 EAVAILKRTKGTVTLMV 2039
            EAV +L+    T+T++V
Sbjct: 1172 EAVQLLRSVGDTLTVLV 1188



 Score =  137 bits (344), Expect = 1e-31
 Identities = 140/504 (27%), Positives = 216/504 (42%), Gaps = 81/504 (16%)

Query: 1359 GLGLSLAGNKDRSRMS-----VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQN 1413
            GLG+S+AG K  +        +FI  +   G A + G +++ D+LLE+NG  L G  H  
Sbjct: 737  GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795

Query: 1414 ASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAV 1473
            A   ++ A + V++   R +    + AV     + PL    +    +     +       
Sbjct: 796  AVEALRGAGTAVQMRVWRERMVEPENAV----TITPLRPEDDYSPRERRGGGLRLPLLPP 851

Query: 1474 DLSSFKNVQHLE-LPKDQGGLGIAISEEDTLS-------GVIIKSLTEHGVAATDGRLKV 1525
            +       +H+  L + + GLG +I+     +       G+ +  + E G A   G L+V
Sbjct: 852  ESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQV 911

Query: 1526 GDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSS 1585
            GD++L+++   V     +  +SLL  A  T+ L +  E             A G      
Sbjct: 912  GDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE-------------AGG------ 952

Query: 1586 QSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTI------------EIS 1633
                 P   SP P S   T+  +T +I  + P   P +P    ++            EI 
Sbjct: 953  -----PLPPSPLPHSSPPTAAVATTSITTATPGV-PGLPSLAPSLLAAALEGPYPVEEIR 1006

Query: 1634 KGRTG--LGLSIVGGSD-------TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
              R G  LGLSIVGGSD            + I +V   G A + G L  GD+IL VNG D
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065

Query: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKR 1744
            +R ATH EA++ L +    + L + RD AP    E+C      +QK PG+ LG+SI G  
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC------IQKAPGERLGISIRGGA 1119

Query: 1745 N----------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKV 1794
                       D G+F+S +   G A  DGRL  G ++L VN + +   T      LL+ 
Sbjct: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179

Query: 1795 SEGSLSSFTFPLSGSSTSESLESS 1818
               +L+        +ST  +LE S
Sbjct: 1180 VGDTLTVLVCDGFEASTDAALEVS 1203



 Score =  133 bits (335), Expect = 2e-30
 Identities = 141/529 (26%), Positives = 218/529 (41%), Gaps = 134/529 (25%)

Query: 1484 LELPKDQGGLGIAISE-------EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
            L + +  GGLGI+I+        +    G+ I  ++E G AA  G ++VGD++L V+   
Sbjct: 729  LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787

Query: 1537 VVGYPIEKFISLLKTAKMTVKLTIHAEN---PDSQAV--PSAAGAASGEKKNSSQSLMVP 1591
            + G    + +  L+ A   V++ +  E    P++     P         ++     L +P
Sbjct: 788  LQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLP 847

Query: 1592 QSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLL 1651
                  P  +R                 C           +++   GLG SI GG  +  
Sbjct: 848  LLPPESPGPLRQRH------------VAC-----------LARSERGLGFSIAGGKGSTP 884

Query: 1652 -----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
                   I +  + E GAA + G L  GD++L +NG+D+ +A HD A+++L      + L
Sbjct: 885  YRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944

Query: 1707 TLYRD-----------------------------------------------EAPYKEEE 1719
             L R+                                               E PY  EE
Sbjct: 945  LLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004

Query: 1720 VCDTLTIELQKKPGKGLGLSIVGKRN---------DTGVFVSDIVKGGIADADGRLMQGD 1770
            +          + G  LGLSIVG  +         + GVF+S ++  G+A   G L  GD
Sbjct: 1005 I-------RLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGD 1056

Query: 1771 QILMVNGEDVRNAT-QEAVAALLKVS-EGSLSSFTFPLSGSSTSESLESSSKKNALASEI 1828
            +IL VNG+DVR+AT QEAV+ALL+   E SL     P                       
Sbjct: 1057 RILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAP--------------------- 1095

Query: 1829 QGLRTVEMKKGPTDSLGISIAGGVGSPLG------DVPIFIAMMHPTGVAAQTQKLRVGD 1882
             GLR + ++K P + LGISI GG     G      D  IFI+ + PTG A +  +LRVG 
Sbjct: 1096 PGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155

Query: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEP 1931
            R++ +   S  G+TH +AV LL++   ++ + V  G + S     +  P
Sbjct: 1156 RLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP 1204



 Score =  112 bits (281), Expect = 3e-24
 Identities = 143/563 (25%), Positives = 216/563 (38%), Gaps = 148/563 (26%)

Query: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
            LGISI GG+G      + E   GIFI  V E+ PA + G ++ GD+++EV+G+ L+ A H
Sbjct: 738  LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793

Query: 1222 EQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
             +AVEA+R AG  V   V                  +    N  +  P    L+   D +
Sbjct: 794  HEAVEALRGAGTAVQMRVWR--------------ERMVEPENAVTITP----LRPEDDYS 835

Query: 1282 PSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERY 1341
            P +      + PL  +PP  P                                  +R+R 
Sbjct: 836  PRERRGGGLRLPL--LPPESPGP--------------------------------LRQR- 860

Query: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRM-----SVFIVGIDPNGAAGKDGRLQIAD 1396
                   H+  L +   GLG S+AG K  +        +F+  I   GAA + G LQ+ D
Sbjct: 861  -------HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913

Query: 1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN----AVEPLPS 1452
             +L ING  +    H +A S++  A   + ++  R        +  P +    A     S
Sbjct: 914  RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTS 973

Query: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLS-------- 1504
             +         P++  S  A  L     V+ + LP+  G LG++I      S        
Sbjct: 974  ITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQE 1033

Query: 1505 -GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563
             GV I  +   G+AA  G L+VGD+ILAV+ + V     ++ +S L    + + L +  +
Sbjct: 1034 PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD 1092

Query: 1564 NPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPII 1623
                                            P P  +R                     
Sbjct: 1093 --------------------------------PAPPGLR--------------------- 1099

Query: 1624 PGCETTIEISKGRTGLGLSIVGGS--------DTLLGAIIIHEVYEEGAACKDGRLWAGD 1675
               E  I+ + G   LG+SI GG+        D     I I +V   GAA +DGRL  G 
Sbjct: 1100 ---ELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155

Query: 1676 QILEVNGIDLRKATHDEAINVLR 1698
            ++LEVN   L   TH EA+ +LR
Sbjct: 1156 RLLEVNQQSLLGLTHGEAVQLLR 1178



 Score =  103 bits (256), Expect = 2e-21
 Identities = 101/353 (28%), Positives = 158/353 (44%), Gaps = 83/353 (23%)

Query: 147  GLGFSVVGLRSEN---RGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
            GLGFS+ G +       G+ GIFV  I EG  AHR G L+  D++L+ING  + +   H 
Sbjct: 871  GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEA-RHD 929

Query: 204  QAISILQKAKDTVQLVIAR---GSLPQLVSPIVSRSPSAASTIS---------------- 244
             A+S+L  A  T+ L++ R   G LP    P  S   +A +T S                
Sbjct: 930  HAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAP 989

Query: 245  -----AHSNPVHWQHMETIELVNDGSGLGFGIIGG----------KATGVIVKTILPGGV 289
                 A   P     +E I L   G  LG  I+GG          +  GV +  +LP G+
Sbjct: 990  SLLAAALEGPYP---VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGL 1046

Query: 290  ADQHGRLCSGDHILKIGDTDLAGMS-SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALG 348
            A + G L  GD IL +   D+   +  E V+ +LR C   + L++ R             
Sbjct: 1047 AARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRR------------- 1091

Query: 349  ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG----YIGDKKLEPS- 403
                 +P    EL +  +   GE               LGI+I G    + G+ + +P+ 
Sbjct: 1092 ---DPAPPGLRELCIQKAP--GER--------------LGISIRGGARGHAGNPR-DPTD 1131

Query: 404  -GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTV 455
             GIF+  ++ + A   DGR+++G +++ V+  +L G T+ +AV++LR  G T+
Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTL 1184



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 126/597 (21%), Positives = 226/597 (37%), Gaps = 148/597 (24%)

Query: 992  AECVMLQNVSKESFERTINIAKGNSSLGMTVSANK-------DGLGMIVRSIIHGGAISR 1044
            A  ++++    E  E T+ I +    LG++++  K       D  G+ +  +   G  +R
Sbjct: 712  ANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771

Query: 1045 DGRIAIGDCILSINEESTISVTNAQARAMLR-----------RHSLIGPDIKITYVPAEH 1093
             G + +GD +L +N  +     + +A   LR           R  ++ P+  +T  P   
Sbjct: 772  AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830

Query: 1094 LEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVE 1153
             +++  S  ++ G            G  +P LP    G   +              R V 
Sbjct: 831  EDDY--SPRERRGG-----------GLRLPLLPPESPGPLRQ--------------RHVA 863

Query: 1154 LWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDG 1213
                  + LG SI GG+G  +    G+   GIF+  + E   A + GTL+ GDR++ ++G
Sbjct: 864  CLARSERGLGFSIAGGKG-STPYRAGDA--GIFVSRIAEGGAAHRAGTLQVGDRVLSING 920

Query: 1214 MDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADS 1273
            +D+ +A H+ AV ++  A +P + +   ++ R    PLP               +P   S
Sbjct: 921  VDVTEARHDHAV-SLLTAASPTIAL---LLEREAGGPLP--------------PSPLPHS 962

Query: 1274 LQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYS 1333
                A  A +   +     P   +P   PS  A                           
Sbjct: 963  SPPTAAVATTSITTATPGVP--GLPSLAPSLLA--------------------------- 993

Query: 1334 WKNIRERYGTLTGELHMIELEKGHSG--LGLSLAGNKDRS-------RMSVFIVGIDPNG 1384
                      L G   + E+    +G  LGLS+ G  D S          VFI  + P G
Sbjct: 994  --------AALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRG 1045

Query: 1385 AAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPG 1444
             A + G L++ D +L +NGQ +   +HQ A S +     ++ ++  R+        +C  
Sbjct: 1046 LAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC-- 1102

Query: 1445 NAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEED-TL 1503
              ++  P                              + L +    G  G A +  D T 
Sbjct: 1103 --IQKAPG-----------------------------ERLGISIRGGARGHAGNPRDPTD 1131

Query: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
             G+ I  ++  G A  DGRL+VG ++L V+ + ++G    + + LL++   T+ + +
Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 129/537 (24%), Positives = 210/537 (39%), Gaps = 107/537 (19%)

Query: 257  TIELVNDGSGLGFGIIGGKAT--------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
            T+ ++    GLG  I GGK +        G+ +  +   G A + G +  GD +L++   
Sbjct: 728  TLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGV 786

Query: 309  DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGIT-LSSSPTSTPELRVDAST 367
             L G    +  + LR  G  V++ + R  + E     A+ IT L      +P  R     
Sbjct: 787  ALQGAEHHEAVEALRGAGTAVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGL 844

Query: 368  Q--------KGEESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVE 417
            +         G   +     L ++ +GLG +IAG  G    +   +GIFV  I +  A  
Sbjct: 845  RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904

Query: 418  HDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVT 477
              G +Q+GD++++++G ++    +  AV +L     T+ L L       E E       +
Sbjct: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-------EREAGGPLPPS 957

Query: 478  KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEI--EEIEDAQKQEA 535
                 SP  A++            ++T  T   P    G P L+  +    +E     E 
Sbjct: 958  PLPHSSPPTAAV------------ATTSITTATP-GVPGLPSLAPSLLAAALEGPYPVEE 1004

Query: 536  ALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFS 595
              L +    +G++   +V      S   G+    E  V   FI  VLP G    SG L  
Sbjct: 1005 IRLPRAGGPLGLS---IVGGSDHSSHPFGV---QEPGV---FISKVLPRGLAARSG-LRV 1054

Query: 596  GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
            GD +L VNG  +    HQ+ V+ L    +E++++  R   PP  +      +LC   + +
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR------ELC---IQK 1105

Query: 656  KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
             P    GE +G                                  I +  G++G      
Sbjct: 1106 AP----GERLG----------------------------------ISIRGGARG------ 1121

Query: 716  DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
               +P DP    I I  + P G A +DGRL  G RL+ VN  +L   +  EAV+ L+
Sbjct: 1122 HAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 98/416 (23%), Positives = 164/416 (39%), Gaps = 76/416 (18%)

Query: 372  ESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
            E E   + + +   GLGI+IAG  G    K +  GIF+  +++       G +++GD+++
Sbjct: 723  EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781

Query: 430  AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489
             V+G  LQG  + +AVE LR  G  V + + R  M +    ++   +  + D SP     
Sbjct: 782  EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSP----- 836

Query: 490  IKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY 549
                     +         +LP E  G PL           +++  A L + +R  G+ +
Sbjct: 837  --------RERRGGGLRLPLLPPESPG-PL-----------RQRHVACLARSER--GLGF 874

Query: 550  EIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
             I     S        GI         F+  +   G    +G L  GD +L +NG+ +  
Sbjct: 875  SIAGGKGSTPYRAGDAGI---------FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925

Query: 610  ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669
              H   V++L      + ++  R    P   S L             PH         S 
Sbjct: 926  ARHDHAVSLLTAASPTIALLLEREAGGPLPPSPL-------------PH---------SS 963

Query: 670  TEDPVLAMTDAGQSTEEVQ-----APLAMWEA-----GIQHIELEKGSKGLGFSILDYQD 719
                 +A T    +T  V      AP  +  A      ++ I L +    LG SI+   D
Sbjct: 964  PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD 1023

Query: 720  ----PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
                P       + I  ++P G+A + G L  GDR++ VN  ++ +++ +EAV AL
Sbjct: 1024 HSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 86/319 (26%), Positives = 127/319 (39%), Gaps = 64/319 (20%)

Query: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQR---------IMGINYE------IVVAHVS 557
           EEEG P    E EE E+  ++E A   +  +         + G++++      I  A + 
Sbjct: 664 EEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIE 723

Query: 558 K-------FSENSGLGISLEATVGHH---------FIRSVLPEGPVGHSGKLFSGDELLE 601
           +         +  GLGIS+    G           FI  V  EGP   +G +  GD+LLE
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782

Query: 602 VNGITLLGENHQDVVNILKELPIEVTM-VCCRRTVPPTTQSELDSLDLCDIELTEKPHVD 660
           VNG+ L G  H + V  L+     V M V   R V P     +  L         +P  D
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL---------RPEDD 833

Query: 661 LG--EFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQ 718
               E  G      P+L     G   +   A LA            +  +GLGFSI   +
Sbjct: 834 YSPRERRGGG-LRLPLLPPESPGPLRQRHVACLA------------RSERGLGFSIAGGK 880

Query: 719 --DPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPS 776
              P       I +  +  GG A + G L  GDR++ +N V++  +  + AV  L  A S
Sbjct: 881 GSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA-S 939

Query: 777 GTVRIGVAK----PLPLSP 791
            T+ + + +    PLP SP
Sbjct: 940 PTIALLLEREAGGPLPPSP 958



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 56/218 (25%), Positives = 97/218 (44%), Gaps = 46/218 (21%)

Query: 137  VFELLKPPSGG-LGFSVVGLRSENRG-----ELGIFVQEIQEGSVAHRDGRLKETDQILA 190
            V E+  P +GG LG S+VG    +       E G+F+ ++    +A R G L+  D+ILA
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060

Query: 191  INGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPI-VSRSPSAASTISAHSNP 249
            +NGQ + +  THQ+A+S L +    + L++ R   P  +  + + ++P            
Sbjct: 1061 VNGQDV-RDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAP------------ 1107

Query: 250  VHWQHMETIELVNDGSGLGFGIIGGKA-----------TGVIVKTILPGGVADQHGRLCS 298
                          G  LG  I GG              G+ +  + P G A + GRL  
Sbjct: 1108 --------------GERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153

Query: 299  GDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
            G  +L++    L G++  +  Q+LR  G+ + +++  G
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 30/88 (34%), Positives = 46/88 (52%), Gaps = 3/88 (3%)

Query: 1365 AGN-KDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS 1423
            AGN +D +   +FI  + P GAAG+DGRL++   LLE+N Q L G +H  A  +++    
Sbjct: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182

Query: 1424 KVKIIFIRNKDAVNQMA--VCPGNAVEP 1449
             + ++     +A    A  V PG    P
Sbjct: 1183 TLTVLVCDGFEASTDAALEVSPGVIANP 1210



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 22/55 (40%), Positives = 31/55 (56%)

Query: 577  FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCC 631
            FI  V P G  G  G+L  G  LLEVN  +LLG  H + V +L+ +   +T++ C
Sbjct: 1135 FISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score =  150 bits (379), Expect = 1e-35
 Identities = 147/497 (29%), Positives = 215/497 (43%), Gaps = 118/497 (23%)

Query: 1627 ETTIEISKGRTGLGLSIVGGSDTLL-----GAIIIHEVYEEGAACKDGRLWAGDQILEVN 1681
            E T+ I +   GLG+SI GG  +         I I  V EEG A + G +  GD++LEVN
Sbjct: 726  ELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVN 784

Query: 1682 GIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT------------------ 1723
            G+ L+ A H EA+  LR     V++ ++R+     E  V  T                  
Sbjct: 785  GVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGL 844

Query: 1724 -LTIELQKKPG--------------KGLGLSIVG-------KRNDTGVFVSDIVKGGIAD 1761
             L +   + PG              +GLG SI G       +  D G+FVS I +GG A 
Sbjct: 845  RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904

Query: 1762 ADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE------------GSLSSFTFPLSGS 1809
              G L  GD++L +NG DV  A  +   +LL  +             G L     P S  
Sbjct: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSP 964

Query: 1810 STSESLES-------------SSKKNALASEIQGLRTVEMKKGPT--DSLGISIAGG--- 1851
             T+    +             S   + LA+ ++G   VE  + P     LG+SI GG   
Sbjct: 965  PTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDH 1024

Query: 1852 VGSPLG--DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG 1909
               P G  +  +FI+ + P G+AA++  LRVGDRI+ + G      TH +AV        
Sbjct: 1025 SSHPFGVQEPGVFISKVLPRGLAARS-GLRVGDRILAVNGQDVRDATHQEAV-------- 1075

Query: 1910 SIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGP-DGL 1968
                                    S+L    L  S + + D  PP  + + +++ P + L
Sbjct: 1076 ------------------------SALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERL 1111

Query: 1969 GFSIVGG----YGSPHG--DLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHE 2022
            G SI GG     G+P    D  I++  V   GAA  DGRL+ G +++ VN QSL G+TH 
Sbjct: 1112 GISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHG 1171

Query: 2023 EAVAILKRTKGTVTLMV 2039
            EAV +L+    T+T++V
Sbjct: 1172 EAVQLLRSVGDTLTVLV 1188



 Score =  137 bits (344), Expect = 1e-31
 Identities = 140/504 (27%), Positives = 216/504 (42%), Gaps = 81/504 (16%)

Query: 1359 GLGLSLAGNKDRSRMS-----VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQN 1413
            GLG+S+AG K  +        +FI  +   G A + G +++ D+LLE+NG  L G  H  
Sbjct: 737  GLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHE 795

Query: 1414 ASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAV 1473
            A   ++ A + V++   R +    + AV     + PL    +    +     +       
Sbjct: 796  AVEALRGAGTAVQMRVWRERMVEPENAV----TITPLRPEDDYSPRERRGGGLRLPLLPP 851

Query: 1474 DLSSFKNVQHLE-LPKDQGGLGIAISEEDTLS-------GVIIKSLTEHGVAATDGRLKV 1525
            +       +H+  L + + GLG +I+     +       G+ +  + E G A   G L+V
Sbjct: 852  ESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQV 911

Query: 1526 GDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSS 1585
            GD++L+++   V     +  +SLL  A  T+ L +  E             A G      
Sbjct: 912  GDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLERE-------------AGG------ 952

Query: 1586 QSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTI------------EIS 1633
                 P   SP P S   T+  +T +I  + P   P +P    ++            EI 
Sbjct: 953  -----PLPPSPLPHSSPPTAAVATTSITTATPGV-PGLPSLAPSLLAAALEGPYPVEEIR 1006

Query: 1634 KGRTG--LGLSIVGGSD-------TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
              R G  LGLSIVGGSD            + I +V   G A + G L  GD+IL VNG D
Sbjct: 1007 LPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065

Query: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKR 1744
            +R ATH EA++ L +    + L + RD AP    E+C      +QK PG+ LG+SI G  
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC------IQKAPGERLGISIRGGA 1119

Query: 1745 N----------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKV 1794
                       D G+F+S +   G A  DGRL  G ++L VN + +   T      LL+ 
Sbjct: 1120 RGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS 1179

Query: 1795 SEGSLSSFTFPLSGSSTSESLESS 1818
               +L+        +ST  +LE S
Sbjct: 1180 VGDTLTVLVCDGFEASTDAALEVS 1203



 Score =  133 bits (335), Expect = 2e-30
 Identities = 141/529 (26%), Positives = 218/529 (41%), Gaps = 134/529 (25%)

Query: 1484 LELPKDQGGLGIAISE-------EDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
            L + +  GGLGI+I+        +    G+ I  ++E G AA  G ++VGD++L V+   
Sbjct: 729  LTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGVA 787

Query: 1537 VVGYPIEKFISLLKTAKMTVKLTIHAEN---PDSQAV--PSAAGAASGEKKNSSQSLMVP 1591
            + G    + +  L+ A   V++ +  E    P++     P         ++     L +P
Sbjct: 788  LQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLP 847

Query: 1592 QSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLL 1651
                  P  +R                 C           +++   GLG SI GG  +  
Sbjct: 848  LLPPESPGPLRQRH------------VAC-----------LARSERGLGFSIAGGKGSTP 884

Query: 1652 -----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1706
                   I +  + E GAA + G L  GD++L +NG+D+ +A HD A+++L      + L
Sbjct: 885  YRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIAL 944

Query: 1707 TLYRD-----------------------------------------------EAPYKEEE 1719
             L R+                                               E PY  EE
Sbjct: 945  LLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEE 1004

Query: 1720 VCDTLTIELQKKPGKGLGLSIVGKRN---------DTGVFVSDIVKGGIADADGRLMQGD 1770
            +          + G  LGLSIVG  +         + GVF+S ++  G+A   G L  GD
Sbjct: 1005 I-------RLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGD 1056

Query: 1771 QILMVNGEDVRNAT-QEAVAALLKVS-EGSLSSFTFPLSGSSTSESLESSSKKNALASEI 1828
            +IL VNG+DVR+AT QEAV+ALL+   E SL     P                       
Sbjct: 1057 RILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAP--------------------- 1095

Query: 1829 QGLRTVEMKKGPTDSLGISIAGGVGSPLG------DVPIFIAMMHPTGVAAQTQKLRVGD 1882
             GLR + ++K P + LGISI GG     G      D  IFI+ + PTG A +  +LRVG 
Sbjct: 1096 PGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155

Query: 1883 RIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEP 1931
            R++ +   S  G+TH +AV LL++   ++ + V  G + S     +  P
Sbjct: 1156 RLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSP 1204



 Score =  112 bits (281), Expect = 3e-24
 Identities = 143/563 (25%), Positives = 216/563 (38%), Gaps = 148/563 (26%)

Query: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
            LGISI GG+G      + E   GIFI  V E+ PA + G ++ GD+++EV+G+ L+ A H
Sbjct: 738  LGISIAGGKGSTPYKGDDE---GIFISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEH 793

Query: 1222 EQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
             +AVEA+R AG  V   V                  +    N  +  P    L+   D +
Sbjct: 794  HEAVEALRGAGTAVQMRVWR--------------ERMVEPENAVTITP----LRPEDDYS 835

Query: 1282 PSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERY 1341
            P +      + PL  +PP  P                                  +R+R 
Sbjct: 836  PRERRGGGLRLPL--LPPESPGP--------------------------------LRQR- 860

Query: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRM-----SVFIVGIDPNGAAGKDGRLQIAD 1396
                   H+  L +   GLG S+AG K  +        +F+  I   GAA + G LQ+ D
Sbjct: 861  -------HVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGD 913

Query: 1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN----AVEPLPS 1452
             +L ING  +    H +A S++  A   + ++  R        +  P +    A     S
Sbjct: 914  RVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTS 973

Query: 1453 NSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLS-------- 1504
             +         P++  S  A  L     V+ + LP+  G LG++I      S        
Sbjct: 974  ITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQE 1033

Query: 1505 -GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563
             GV I  +   G+AA  G L+VGD+ILAV+ + V     ++ +S L    + + L +  +
Sbjct: 1034 PGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRD 1092

Query: 1564 NPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPII 1623
                                            P P  +R                     
Sbjct: 1093 --------------------------------PAPPGLR--------------------- 1099

Query: 1624 PGCETTIEISKGRTGLGLSIVGGS--------DTLLGAIIIHEVYEEGAACKDGRLWAGD 1675
               E  I+ + G   LG+SI GG+        D     I I +V   GAA +DGRL  G 
Sbjct: 1100 ---ELCIQKAPGER-LGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGL 1155

Query: 1676 QILEVNGIDLRKATHDEAINVLR 1698
            ++LEVN   L   TH EA+ +LR
Sbjct: 1156 RLLEVNQQSLLGLTHGEAVQLLR 1178



 Score =  103 bits (256), Expect = 2e-21
 Identities = 101/353 (28%), Positives = 158/353 (44%), Gaps = 83/353 (23%)

Query: 147  GLGFSVVGLRSEN---RGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
            GLGFS+ G +       G+ GIFV  I EG  AHR G L+  D++L+ING  + +   H 
Sbjct: 871  GLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEA-RHD 929

Query: 204  QAISILQKAKDTVQLVIAR---GSLPQLVSPIVSRSPSAASTIS---------------- 244
             A+S+L  A  T+ L++ R   G LP    P  S   +A +T S                
Sbjct: 930  HAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAP 989

Query: 245  -----AHSNPVHWQHMETIELVNDGSGLGFGIIGG----------KATGVIVKTILPGGV 289
                 A   P     +E I L   G  LG  I+GG          +  GV +  +LP G+
Sbjct: 990  SLLAAALEGPYP---VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGL 1046

Query: 290  ADQHGRLCSGDHILKIGDTDLAGMS-SEQVAQVLRQCGNRVKLMIARGAIEERTAPTALG 348
            A + G L  GD IL +   D+   +  E V+ +LR C   + L++ R             
Sbjct: 1047 AARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPC-LELSLLVRR------------- 1091

Query: 349  ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG----YIGDKKLEPS- 403
                 +P    EL +  +   GE               LGI+I G    + G+ + +P+ 
Sbjct: 1092 ---DPAPPGLRELCIQKAP--GER--------------LGISIRGGARGHAGNPR-DPTD 1131

Query: 404  -GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTV 455
             GIF+  ++ + A   DGR+++G +++ V+  +L G T+ +AV++LR  G T+
Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTL 1184



 Score = 91.7 bits (226), Expect = 7e-18
 Identities = 126/597 (21%), Positives = 226/597 (37%), Gaps = 148/597 (24%)

Query: 992  AECVMLQNVSKESFERTINIAKGNSSLGMTVSANK-------DGLGMIVRSIIHGGAISR 1044
            A  ++++    E  E T+ I +    LG++++  K       D  G+ +  +   G  +R
Sbjct: 712  ANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAAR 771

Query: 1045 DGRIAIGDCILSINEESTISVTNAQARAMLR-----------RHSLIGPDIKITYVPAEH 1093
             G + +GD +L +N  +     + +A   LR           R  ++ P+  +T  P   
Sbjct: 772  AG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRP 830

Query: 1094 LEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVE 1153
             +++  S  ++ G            G  +P LP    G   +              R V 
Sbjct: 831  EDDY--SPRERRGG-----------GLRLPLLPPESPGPLRQ--------------RHVA 863

Query: 1154 LWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDG 1213
                  + LG SI GG+G  +    G+   GIF+  + E   A + GTL+ GDR++ ++G
Sbjct: 864  CLARSERGLGFSIAGGKG-STPYRAGDA--GIFVSRIAEGGAAHRAGTLQVGDRVLSING 920

Query: 1214 MDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADS 1273
            +D+ +A H+ AV ++  A +P + +   ++ R    PLP               +P   S
Sbjct: 921  VDVTEARHDHAV-SLLTAASPTIAL---LLEREAGGPLP--------------PSPLPHS 962

Query: 1274 LQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYS 1333
                A  A +   +     P   +P   PS  A                           
Sbjct: 963  SPPTAAVATTSITTATPGVP--GLPSLAPSLLA--------------------------- 993

Query: 1334 WKNIRERYGTLTGELHMIELEKGHSG--LGLSLAGNKDRS-------RMSVFIVGIDPNG 1384
                      L G   + E+    +G  LGLS+ G  D S          VFI  + P G
Sbjct: 994  --------AALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRG 1045

Query: 1385 AAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPG 1444
             A + G L++ D +L +NGQ +   +HQ A S +     ++ ++  R+        +C  
Sbjct: 1046 LAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELC-- 1102

Query: 1445 NAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEED-TL 1503
              ++  P                              + L +    G  G A +  D T 
Sbjct: 1103 --IQKAPG-----------------------------ERLGISIRGGARGHAGNPRDPTD 1131

Query: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
             G+ I  ++  G A  DGRL+VG ++L V+ + ++G    + + LL++   T+ + +
Sbjct: 1132 EGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 129/537 (24%), Positives = 210/537 (39%), Gaps = 107/537 (19%)

Query: 257  TIELVNDGSGLGFGIIGGKAT--------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
            T+ ++    GLG  I GGK +        G+ +  +   G A + G +  GD +L++   
Sbjct: 728  TLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEVNGV 786

Query: 309  DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGIT-LSSSPTSTPELRVDAST 367
             L G    +  + LR  G  V++ + R  + E     A+ IT L      +P  R     
Sbjct: 787  ALQGAEHHEAVEALRGAGTAVQMRVWRERMVE--PENAVTITPLRPEDDYSPRERRGGGL 844

Query: 368  Q--------KGEESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVE 417
            +         G   +     L ++ +GLG +IAG  G    +   +GIFV  I +  A  
Sbjct: 845  RLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAH 904

Query: 418  HDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVT 477
              G +Q+GD++++++G ++    +  AV +L     T+ L L       E E       +
Sbjct: 905  RAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-------EREAGGPLPPS 957

Query: 478  KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEI--EEIEDAQKQEA 535
                 SP  A++            ++T  T   P    G P L+  +    +E     E 
Sbjct: 958  PLPHSSPPTAAV------------ATTSITTATP-GVPGLPSLAPSLLAAALEGPYPVEE 1004

Query: 536  ALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFS 595
              L +    +G++   +V      S   G+    E  V   FI  VLP G    SG L  
Sbjct: 1005 IRLPRAGGPLGLS---IVGGSDHSSHPFGV---QEPGV---FISKVLPRGLAARSG-LRV 1054

Query: 596  GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
            GD +L VNG  +    HQ+ V+ L    +E++++  R   PP  +      +LC   + +
Sbjct: 1055 GDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLR------ELC---IQK 1105

Query: 656  KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
             P    GE +G                                  I +  G++G      
Sbjct: 1106 AP----GERLG----------------------------------ISIRGGARG------ 1121

Query: 716  DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
               +P DP    I I  + P G A +DGRL  G RL+ VN  +L   +  EAV+ L+
Sbjct: 1122 HAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 98/416 (23%), Positives = 164/416 (39%), Gaps = 76/416 (18%)

Query: 372  ESETFDVELTKNVQGLGITIAGYIGDK--KLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
            E E   + + +   GLGI+IAG  G    K +  GIF+  +++       G +++GD+++
Sbjct: 723  EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLL 781

Query: 430  AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489
             V+G  LQG  + +AVE LR  G  V + + R  M +    ++   +  + D SP     
Sbjct: 782  EVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSP----- 836

Query: 490  IKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY 549
                     +         +LP E  G PL           +++  A L + +R  G+ +
Sbjct: 837  --------RERRGGGLRLPLLPPESPG-PL-----------RQRHVACLARSER--GLGF 874

Query: 550  EIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
             I     S        GI         F+  +   G    +G L  GD +L +NG+ +  
Sbjct: 875  SIAGGKGSTPYRAGDAGI---------FVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925

Query: 610  ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669
              H   V++L      + ++  R    P   S L             PH         S 
Sbjct: 926  ARHDHAVSLLTAASPTIALLLEREAGGPLPPSPL-------------PH---------SS 963

Query: 670  TEDPVLAMTDAGQSTEEVQ-----APLAMWEA-----GIQHIELEKGSKGLGFSILDYQD 719
                 +A T    +T  V      AP  +  A      ++ I L +    LG SI+   D
Sbjct: 964  PPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSD 1023

Query: 720  ----PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
                P       + I  ++P G+A + G L  GDR++ VN  ++ +++ +EAV AL
Sbjct: 1024 HSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSAL 1078



 Score = 65.1 bits (157), Expect = 7e-10
 Identities = 86/319 (26%), Positives = 127/319 (39%), Gaps = 64/319 (20%)

Query: 513 EEEGYPLLSAEIEEIEDAQKQEAALLTKWQR---------IMGINYE------IVVAHVS 557
           EEEG P    E EE E+  ++E A   +  +         + G++++      I  A + 
Sbjct: 664 EEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIE 723

Query: 558 K-------FSENSGLGISLEATVGHH---------FIRSVLPEGPVGHSGKLFSGDELLE 601
           +         +  GLGIS+    G           FI  V  EGP   +G +  GD+LLE
Sbjct: 724 EEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLE 782

Query: 602 VNGITLLGENHQDVVNILKELPIEVTM-VCCRRTVPPTTQSELDSLDLCDIELTEKPHVD 660
           VNG+ L G  H + V  L+     V M V   R V P     +  L         +P  D
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPL---------RPEDD 833

Query: 661 LG--EFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQ 718
               E  G      P+L     G   +   A LA            +  +GLGFSI   +
Sbjct: 834 YSPRERRGGG-LRLPLLPPESPGPLRQRHVACLA------------RSERGLGFSIAGGK 880

Query: 719 --DPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPS 776
              P       I +  +  GG A + G L  GDR++ +N V++  +  + AV  L  A S
Sbjct: 881 GSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAA-S 939

Query: 777 GTVRIGVAK----PLPLSP 791
            T+ + + +    PLP SP
Sbjct: 940 PTIALLLEREAGGPLPPSP 958



 Score = 63.9 bits (154), Expect = 2e-09
 Identities = 56/218 (25%), Positives = 97/218 (44%), Gaps = 46/218 (21%)

Query: 137  VFELLKPPSGG-LGFSVVGLRSENRG-----ELGIFVQEIQEGSVAHRDGRLKETDQILA 190
            V E+  P +GG LG S+VG    +       E G+F+ ++    +A R G L+  D+ILA
Sbjct: 1002 VEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILA 1060

Query: 191  INGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPI-VSRSPSAASTISAHSNP 249
            +NGQ + +  THQ+A+S L +    + L++ R   P  +  + + ++P            
Sbjct: 1061 VNGQDV-RDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAP------------ 1107

Query: 250  VHWQHMETIELVNDGSGLGFGIIGGKA-----------TGVIVKTILPGGVADQHGRLCS 298
                          G  LG  I GG              G+ +  + P G A + GRL  
Sbjct: 1108 --------------GERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRV 1153

Query: 299  GDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
            G  +L++    L G++  +  Q+LR  G+ + +++  G
Sbjct: 1154 GLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG 1191



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 30/88 (34%), Positives = 46/88 (52%), Gaps = 3/88 (3%)

Query: 1365 AGN-KDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS 1423
            AGN +D +   +FI  + P GAAG+DGRL++   LLE+N Q L G +H  A  +++    
Sbjct: 1123 AGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGD 1182

Query: 1424 KVKIIFIRNKDAVNQMA--VCPGNAVEP 1449
             + ++     +A    A  V PG    P
Sbjct: 1183 TLTVLVCDGFEASTDAALEVSPGVIANP 1210



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 22/55 (40%), Positives = 31/55 (56%)

Query: 577  FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCC 631
            FI  V P G  G  G+L  G  LLEVN  +LLG  H + V +L+ +   +T++ C
Sbjct: 1135 FISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVC 1189


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score =  139 bits (350), Expect = 3e-32
 Identities = 146/581 (25%), Positives = 238/581 (40%), Gaps = 125/581 (21%)

Query: 133  RHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
            R + +  L K    GLGF ++G     R +LGIF+  +  G  A  DG LK  D+++++N
Sbjct: 898  REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 957

Query: 193  GQALDQTITHQQAISILQKAKDTVQLVIARG--------SLP-----QLVSPIVSRSPSA 239
              +L+  ++H  AI ILQ A + V LVI++         S P     ++ + +   S   
Sbjct: 958  SVSLEG-VSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ 1016

Query: 240  ASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSG 299
             S I + S   HW    T+  +++ S   FG  GG         +  G ++ Q  R  S 
Sbjct: 1017 DSAIDSSSKDHHWSR-GTLRHISENS---FGPSGG---------LREGSLSSQDSRTESA 1063

Query: 300  DHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITL-------- 351
                   +   A    +Q  Q   Q G+    +I++   +E    +    T         
Sbjct: 1064 SLSQSQVNGFFASHLGDQTWQE-SQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1122

Query: 352  ----------------SSSPTSTPELRVDASTQKGEE-------------SETFDVELTK 382
                            SS    TP+    +S     +              + F+VEL K
Sbjct: 1123 DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK 1182

Query: 383  NVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQ 442
            N   LGI++ G + +  +   GI+VK++    A E DGRI  GD+++AV+G +L+G T++
Sbjct: 1183 NDNSLGISVTGGV-NTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1241

Query: 443  QAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLS 502
            QAVE LR+TGQ V L L+ +G                                       
Sbjct: 1242 QAVETLRNTGQVVHL-LLEKGQS------------------------------------- 1263

Query: 503  STRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY--EIVVAHVSKFS 560
                    PT +E  P+        ++AQ Q    + K  ++   ++  E     V  F 
Sbjct: 1264 --------PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFK 1315

Query: 561  ENSGLGISL---------EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
             +SGLG S          +       ++ + P  P   SGK+  GD +L+VNG +L G +
Sbjct: 1316 NSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1375

Query: 612  HQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIE 652
             Q+V++ L+    EV ++ CR   PP    E+D+  L  ++
Sbjct: 1376 QQEVISALRGTAPEVFLLLCR--PPPGVLPEIDTALLTPLQ 1414



 Score =  128 bits (322), Expect = 5e-29
 Identities = 140/543 (25%), Positives = 218/543 (40%), Gaps = 91/543 (16%)

Query: 1314 QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS-GLGLSLAGNKDRSR 1372
            Q  A + +QD    D     W  +     +   E+ ++ L+K    GLG  + G +   R
Sbjct: 870  QMRARQSNQDAQDIDVLHKRWSIV----SSPEREITLVNLKKDAKYGLGFQIIGGEKMGR 925

Query: 1373 MS--VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFI 1430
            +   +FI  + P G A  DG L+  D L+ +N   L G SH  A  I++ AP  V ++  
Sbjct: 926  LDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVIS 985

Query: 1431 RNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKN------VQHL 1484
            + K+ ++++   P +    L +  +N   K +       D+A+D SS  +      ++H+
Sbjct: 986  QPKEKISKVPSTPVH----LTNEMKNYMKKSSY----MQDSAIDSSSKDHHWSRGTLRHI 1037

Query: 1485 ELPK--DQGGL--GIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY 1540
                    GGL  G   S++       +     +G  A+     +GDQ      E   G 
Sbjct: 1038 SENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASH----LGDQTW---QESQHGS 1090

Query: 1541 PIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQ-------SLMVPQS 1593
            P    IS     K T K T    N      P  +       +  S        S    Q+
Sbjct: 1091 PSPSVIS-----KATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQT 1145

Query: 1594 GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLL-- 1651
               E  S  NTS       F+S P      PG    +E++K    LG+S+ GG +T +  
Sbjct: 1146 PKQESSSSVNTSNKMNFKTFSSSPPK----PGDIFEVELAKNDNSLGISVTGGVNTSVRH 1201

Query: 1652 GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRD 1711
            G I +  V  +GAA  DGR+  GD++L VNG+ L  ATH +A+  LR T Q V L L + 
Sbjct: 1202 GGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKG 1261

Query: 1712 EAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK---------------------RNDTG-- 1748
            ++P  +E V  T    L  +  +G G   V K                     +N +G  
Sbjct: 1262 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLG 1321

Query: 1749 ------------------VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAA 1790
                              V V  +  G  A   G++  GD IL VNG  ++  +Q+ V +
Sbjct: 1322 FSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVIS 1381

Query: 1791 LLK 1793
             L+
Sbjct: 1382 ALR 1384



 Score =  119 bits (299), Expect = 2e-26
 Identities = 220/992 (22%), Positives = 367/992 (36%), Gaps = 215/992 (21%)

Query: 1132 EGEESELQNTAYSNWNQPRR----VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFI 1187
            + ++ ++ +  +S  + P R    V L ++    LG  I+GG  MG       +  GIFI
Sbjct: 879  DAQDIDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMG------RLDLGIFI 932

Query: 1188 KHVLEDSPAGKNGTLKPGDRI-----VEVDGMD-------LRDASHE------QAVEAIR 1229
              V    PA  +G LKPGDR+     V ++G+        L++A  +      Q  E I 
Sbjct: 933  SSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKIS 992

Query: 1230 KAGNPVVFMVQSIINRPRKSPL--PSLLHNLYPKYNFS-------STNPFADSLQINADK 1280
            K  +  V +   + N  +KS     S + +    +++S       S N F  S  +    
Sbjct: 993  KVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGS 1052

Query: 1281 APSQSESEPEKAPLCSVP--------------------PPPPSAFA-----EMGSDHTQS 1315
              SQ +S  E A L                         P PS  +     E  +D  QS
Sbjct: 1053 LSSQ-DSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQS 1111

Query: 1316 SASK-----------------------ISQDVDKEDEFGYSWKNIRERYGTLT------- 1345
               K                        SQD     +   S  N   +    T       
Sbjct: 1112 KTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPK 1171

Query: 1346 -GELHMIELEKGHSGLGLSLAGNKDRS--RMSVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
             G++  +EL K  + LG+S+ G  + S     +++  + P GAA  DGR+   D +L +N
Sbjct: 1172 PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVN 1231

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
            G  L G +H+ A   ++     V ++  + +   ++  V           N++    ++ 
Sbjct: 1232 GVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKV 1291

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL-------SGVIIKSLTEHG 1515
            + T    D +    + +N   ++L K+  GLG + S ED L       S V +K L    
Sbjct: 1292 KKTTQVKDYS--FVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQ 1349

Query: 1516 VAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAG 1575
             AA  G++ VGD IL V+   + G   ++ IS L+     V L +    P    +P    
Sbjct: 1350 PAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLC--RPPPGVLPEIDT 1407

Query: 1576 AASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKG 1635
            A     ++ +Q L      S +P  +  ++ S    +       C   P    +   S G
Sbjct: 1408 ALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKS-PSRRDSYSDSSG 1466

Query: 1636 RTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAIN 1695
                      G D L+ A           A      W+              A H    N
Sbjct: 1467 ---------SGEDDLVTA----------PANISNSTWSS-------------ALHQTLSN 1494

Query: 1696 VLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV 1755
            ++ Q            EAP  +E+   T+    QK P K                     
Sbjct: 1495 MVSQAQSH-------HEAPKSQEDTICTMFYYPQKIPNKP-------------------- 1527

Query: 1756 KGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL-KVSEGSLSSFTFPLSGSSTSES 1814
                 D++   +  D   M  G+  +  ++ A ++ + K     +S  T   + +     
Sbjct: 1528 --EFEDSNPSPLPPD---MAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKND 1582

Query: 1815 LESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGG---VGSPLGDVPIFIAMMHPTGV 1871
            LE+  +   L  E+  +  ++ +KG   SLG ++  G   +G  + DV     +  P   
Sbjct: 1583 LENHLEDFELEVELL-ITLIKSEKG---SLGFTVTKGNQRIGCYVHDV-----IQDP--- 1630

Query: 1872 AAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEP 1931
            A    +L+ GDR++ +  T    MTHT AVNLL+ AS ++ +          V G   E 
Sbjct: 1631 AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRL----------VIGRVLE- 1679

Query: 1932 ASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVF 1991
                          + +  + P     ITL    + LGFS+ GG+ S +    +Y+  + 
Sbjct: 1680 --------------LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ--VVYISDIN 1723

Query: 1992 AKGAASEDGRLKRGDQIIAVNGQSLEGVTHEE 2023
             +  A+ +G L+  D I  VNG S +G+T EE
Sbjct: 1724 PRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEE 1755



 Score =  110 bits (276), Expect = 1e-23
 Identities = 178/885 (20%), Positives = 340/885 (38%), Gaps = 172/885 (19%)

Query: 266  GLGFGIIGGKATG-----VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
            GLGF IIGG+  G     + + ++ PGG AD  G L  GD ++ +    L G+S     +
Sbjct: 912  GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971

Query: 321  VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTS-TPELRVDASTQKGEESETFDVE 379
            +L+     V L+I++   +    P        S+P   T E++         +    D  
Sbjct: 972  ILQNAPEDVTLVISQPKEKISKVP--------STPVHLTNEMKNYMKKSSYMQDSAIDSS 1023

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
               +    G     +I +    PSG     + + S    D R +      ++  + + GF
Sbjct: 1024 SKDHHWSRGTL--RHISENSFGPSG----GLREGSLSSQDSRTESA----SLSQSQVNGF 1073

Query: 440  ----TNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYE 495
                   Q  +  +H   +   +++ +  ++E    S +  TK   +S V     + + +
Sbjct: 1074 FASHLGDQTWQESQHGSPSP--SVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSD 1131

Query: 496  KDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAH 555
             DE   SS+++    P +E            +  + K      +      G  +E+ +A 
Sbjct: 1132 MDEATYSSSQDHQT-PKQESS--------SSVNTSNKMNFKTFSSSPPKPGDIFEVELA- 1181

Query: 556  VSKFSENSGLGISLEATV------GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
                  ++ LGIS+   V      G  ++++V+P+G     G++  GD +L VNG++L G
Sbjct: 1182 ----KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237

Query: 610  ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669
              H+  V  L+    +V  +   +   PT++  +     C +               +++
Sbjct: 1238 ATHKQAVETLRNTG-QVVHLLLEKGQSPTSKEHVPVTPQCTLS------------DQNAQ 1284

Query: 670  TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL--DYQDPIDPASTV 727
             + P     +  + T +V+    + E     ++L K S GLGFS    D   P    +++
Sbjct: 1285 GQGP-----EKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1339

Query: 728  IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA-----------PS 776
            + ++ L PG  A + G++  GD ++ VN  +L+  S +E + AL+G            P 
Sbjct: 1340 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1399

Query: 777  GTV-RIGVAKPLPL-SPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDAD 834
            G +  I  A   PL SP +   ++ +DS      SC E                 +++ +
Sbjct: 1400 GVLPEIDTALLTPLQSPAQVLPNSSKDS---SQPSCVEQS-------------TSSDENE 1443

Query: 835  LVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVL 894
            + D+S  +       DS           +  S G G +   + P++       ++     
Sbjct: 1444 MSDKSKKQCKSPSRRDS-----------YSDSSGSGEDDLVTAPANISNSTWSSA----- 1487

Query: 895  DLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTE 954
             LH +L  + +Q     +                          A + Q +   T+ +  
Sbjct: 1488 -LHQTLSNMVSQAQSHHE--------------------------APKSQEDTICTMFYYP 1520

Query: 955  SHLPSEVISSAELPSVLPDSAGKGSEYLLE-QSSLACNAECVMLQNVSK----------- 1002
              +P++       PS LP     G  Y  + +S+ + + +   + ++S+           
Sbjct: 1521 QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLK 1580

Query: 1003 -------ESFERTIN-----IAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAI 1050
                   E FE  +      I     SLG TV+     +G  V  +I   A S DGR+  
Sbjct: 1581 NDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKS-DGRLKP 1639

Query: 1051 GDCILSINEESTISVTNAQARAMLRRHS-----LIGPDIKITYVP 1090
            GD ++ +N+    ++T+  A  +LR  S     +IG  +++  +P
Sbjct: 1640 GDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIP 1684



 Score =  103 bits (257), Expect = 2e-21
 Identities = 160/705 (22%), Positives = 274/705 (38%), Gaps = 140/705 (19%)

Query: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
            SLGIS+ GG  + + + +G    GI++K V+    A  +G +  GDR++ V+G+ L  A+
Sbjct: 1186 SLGISVTGG--VNTSVRHG----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGAT 1239

Query: 1221 HEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADK 1280
            H+QAVE +R  G  V                                      L +   +
Sbjct: 1240 HKQAVETLRNTGQVV-------------------------------------HLLLEKGQ 1262

Query: 1281 APSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRER 1340
            +P+  E          VP  P    ++  +        K+ +    +D    + +N  E 
Sbjct: 1263 SPTSKEH---------VPVTPQCTLSDQNAQG--QGPEKVKKTTQVKDYSFVTEENTFE- 1310

Query: 1341 YGTLTGELHMIELEKGHSGLGLSLA--GNKDRSRMSVFIVGID---PNGAAGKDGRLQIA 1395
                      ++L K  SGLG S +   N    +++  IV +    P   A + G++ + 
Sbjct: 1311 ----------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVG 1360

Query: 1396 DELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSE 1455
            D +L++NG  L G S Q   S ++    +V ++  R    V  +       + PL S ++
Sbjct: 1361 DVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGV--LPEIDTALLTPLQSPAQ 1418

Query: 1456 NLQNKE---TEPTVTTSDAAVDLS--SFKNVQHLELPK------DQGGLGIAISEEDTLS 1504
             L N     ++P+      + D +  S K+ +  + P       D  G G    E+D ++
Sbjct: 1419 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG----EDDLVT 1474

Query: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN 1564
                 S +    A       +  Q  +  +      P  +  ++        K+    E 
Sbjct: 1475 APANISNSTWSSALHQTLSNMVSQAQSHHEA-----PKSQEDTICTMFYYPQKIPNKPEF 1529

Query: 1565 PDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPAT----C 1620
             DS   P     A G            QS  P+ ES  ++S         S+P       
Sbjct: 1530 EDSNPSPLPPDMAPG------------QSYQPQSESASSSSMDKYHIHHISEPTRQENWT 1577

Query: 1621 PIIPGCETTIE------------ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKD 1668
            P+    E  +E            I   +  LG ++  G+  +     +H+V ++ A   D
Sbjct: 1578 PLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAK-SD 1634

Query: 1669 GRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR----DEAPYKEEEVCD-T 1723
            GRL  GD++++VN  D+   TH +A+N+LR   + VRL + R       P     + D T
Sbjct: 1635 GRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDIT 1694

Query: 1724 LTIELQKKPGKGLGLSIVGKRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
            LT   ++     LG S+ G  +     V++SDI    +A  +G L   D I  VNG   +
Sbjct: 1695 LTCNKEE-----LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1749

Query: 1782 NATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALAS 1826
              T E V   L +S  SL      L  +     +  SSK++A+++
Sbjct: 1750 GMTLEEVNRALDMSLPSL-----VLKATRNDLPVVPSSKRSAVSA 1789



 Score =  100 bits (249), Expect = 1e-20
 Identities = 75/269 (27%), Positives = 127/269 (47%), Gaps = 25/269 (9%)

Query: 258  IELVNDGSGLGFGIIGGKAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAG 312
            +EL  + + LG  + GG  T     G+ VK ++P G A+  GR+  GD +L +    L G
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237

Query: 313  MSSEQVAQVLRQCGNRVKLMIARG--AIEERTAPTALGITLS--SSPTSTPELRVDASTQ 368
             + +Q  + LR  G  V L++ +G     +   P     TLS  ++    PE +V  +TQ
Sbjct: 1238 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE-KVKKTTQ 1296

Query: 369  KGE-----ESETFDVELTKNVQGLGITIA--GYIGDKKLEPSGIFVKSITKSSAVEHDGR 421
              +     E  TF+V+L KN  GLG + +    +  +++  S + VK +         G+
Sbjct: 1297 VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1356

Query: 422  IQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEAE------LMSR 473
            I +GD I+ V+G +L+G + Q+ +  LR T   V L L R   G+  E +      L S 
Sbjct: 1357 IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSP 1416

Query: 474  EDVTKDADLSPVNASIIKENYEKDEDFLS 502
              V  ++       S ++++   DE+ +S
Sbjct: 1417 AQVLPNSSKDSSQPSCVEQSTSSDENEMS 1445



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 164/730 (22%), Positives = 277/730 (37%), Gaps = 132/730 (18%)

Query: 136  EVFEL-LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
            ++FE+ L      LG SV G  + +    GI+V+ +     A  DGR+ + D++LA+NG 
Sbjct: 1174 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1233

Query: 195  ALDQTITHQQAISILQKAKDTVQLVIARGSLPQL-----VSPIVSRSPSAA--------- 240
            +L+   TH+QA+  L+     V L++ +G  P       V+P  + S   A         
Sbjct: 1234 SLEGA-THKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVK 1292

Query: 241  -STISAHSNPVHWQHMETIELVNDGSGLGFGIIGG--------KATGVIVKTILPGGVAD 291
             +T     + V  ++   ++L  + SGLGF              A+ V VK + PG  A 
Sbjct: 1293 KTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1352

Query: 292  QHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR---GAIEERTAPTALG 348
            + G++  GD ILK+    L G+S ++V   LR     V L++ R   G + E    TAL 
Sbjct: 1353 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPE--IDTALL 1410

Query: 349  ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVK 408
              L S     P    D+S     E  T   E   + +      +    D   + SG    
Sbjct: 1411 TPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED 1470

Query: 409  SITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEA 468
             +  + A      I       A+  T     +  Q+      + +  + T+     K   
Sbjct: 1471 DLVTAPA-----NISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQK--- 1522

Query: 469  ELMSREDVTKDADLSPVNASIIK-ENYEKDEDFLSSTRNTNI------LPTEEEGYPLLS 521
              +  +   +D++ SP+   +   ++Y+   +  SS+            PT +E +  L 
Sbjct: 1523 --IPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLK 1580

Query: 522  AEIE-EIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH---- 576
             ++E  +ED + +   L+T  +                 SE   LG ++  T G+     
Sbjct: 1581 NDLENHLEDFELEVELLITLIK-----------------SEKGSLGFTV--TKGNQRIGC 1621

Query: 577  FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVP 636
            ++  V+ + P    G+L  GD L++VN   +    H D VN+L+     V +V  R    
Sbjct: 1622 YVHDVI-QDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---- 1676

Query: 637  PTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEA 696
                     L+L  I +   PH+                                     
Sbjct: 1677 --------VLELPRIPML--PHL------------------------------------- 1689

Query: 697  GIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVND 756
             +  I L    + LGFS+    D +     V+ I  + P  +A  +G L   D + +VN 
Sbjct: 1690 -LPDITLTCNKEELGFSLCGGHDSL---YQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1745

Query: 757  VNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP--EEGYVSAKED---SFLYPPHSCE 811
            V+ +  +LEE   AL  +    V       LP+ P  +   VSA +    +  Y   SC 
Sbjct: 1746 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1805

Query: 812  EAGLADKPLF 821
            +  L     F
Sbjct: 1806 QPALTPNDSF 1815



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 119/509 (23%), Positives = 191/509 (37%), Gaps = 112/509 (22%)

Query: 1628 TTIEISK-GRTGLGLSIVGGSDT--LLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
            T + + K  + GLG  I+GG     L   I I  V   G A  DG L  GD+++ VN + 
Sbjct: 901  TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 960

Query: 1685 ------------LRKATHD---------EAINVLRQTPQRV--RLTLYRDEAPYKEEEVC 1721
                        L+ A  D         E I+ +  TP  +   +  Y  ++ Y ++   
Sbjct: 961  LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI 1020

Query: 1722 DTLT-------------IELQKKPGKGL---GLSIVGKRNDTGVFVSDIVKGGIADADG- 1764
            D+ +              E    P  GL    LS    R ++       V G  A   G 
Sbjct: 1021 DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD 1080

Query: 1765 RLMQGDQILMVNGEDVRNATQEA-----------------VAALLKVSEGSLSSFTFPLS 1807
            +  Q  Q    +   +  AT++                  V       +  +   T+  S
Sbjct: 1081 QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS 1140

Query: 1808 GSSTSESLESSSKKNALASEIQGLRT-------------VEMKKGPTDSLGISIAGGVGS 1854
                +   ESSS  N   S     +T             VE+ K   +SLGIS+ GGV +
Sbjct: 1141 QDHQTPKQESSSSVNT--SNKMNFKTFSSSPPKPGDIFEVELAKND-NSLGISVTGGVNT 1197

Query: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQ 1914
             +    I++  + P G A    ++  GDR++ + G S EG TH QAV  L+N    + + 
Sbjct: 1198 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLL 1257

Query: 1915 VVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSIT-------------- 1960
            +  G      T  +  P +   + +   +        GP + K  T              
Sbjct: 1258 LEKG---QSPTSKEHVPVTPQCTLSDQNAQG-----QGPEKVKKTTQVKDYSFVTEENTF 1309

Query: 1961 ---LERGPDGLGFSIVGGYGSPHGDLP-------IYVKTVFAKGAASEDGRLKRGDQIIA 2010
               L +   GLGFS    +      +P       + VK +F    A+E G++  GD I+ 
Sbjct: 1310 EVKLFKNSSGLGFS----FSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1365

Query: 2011 VNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            VNG SL+G++ +E ++ L+ T   V L++
Sbjct: 1366 VNGASLKGLSQQEVISALRGTAPEVFLLL 1394



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 63/255 (24%), Positives = 113/255 (44%), Gaps = 36/255 (14%)

Query: 1009 INIAKGNSSLGMTVSANKDGL----GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
            + +AK ++SLG++V+   +      G+ V+++I  GA   DGRI  GD +L++N  S   
Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237

Query: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPE 1124
             T+ QA   LR    +            HL    +  GQ       + +    T  D   
Sbjct: 1238 ATHKQAVETLRNTGQV-----------VHL---LLEKGQSPTSKEHVPVTPQCTLSD--- 1280

Query: 1125 LPEREEGEGEESELQNTAYSNWN-----QPRRVELWREPSKSLGISIVGGRGMGSRLSNG 1179
              +  +G+G E   + T   +++         V+L++  S  LG S      +     N 
Sbjct: 1281 --QNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKN-SSGLGFSFSREDNLIPEQINA 1337

Query: 1180 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV 1239
             ++R   +K +    PA ++G +  GD I++V+G  L+  S ++ + A+R    P VF+ 
Sbjct: 1338 SIVR---VKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTA-PEVFL- 1392

Query: 1240 QSIINRPRKSPLPSL 1254
              ++ RP    LP +
Sbjct: 1393 --LLCRPPPGVLPEI 1405



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 38/93 (40%), Positives = 54/93 (58%), Gaps = 3/93 (3%)

Query: 695 EAGIQHIELEKGSK-GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMF 753
           E  I  + L+K +K GLGF I+   + +      I I S+ PGG A+ DG L PGDRL+ 
Sbjct: 897 EREITLVNLKKDAKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 955

Query: 754 VNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786
           VN V+LE  S   A+E L+ AP   V + +++P
Sbjct: 956 VNSVSLEGVSHHAAIEILQNAPE-DVTLVISQP 987



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 40/225 (17%)

Query: 110  IPHINGKPACDEFDQLIKNMAQGRHVEVFEL--------LKPPSGGLGFSVVGLRSENRG 161
            I HI+ +P   E    +KN  +  H+E FEL        +K   G LGF+V    ++   
Sbjct: 1564 IHHIS-EPTRQENWTPLKNDLEN-HLEDFELEVELLITLIKSEKGSLGFTV----TKGNQ 1617

Query: 162  ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
             +G +V ++ +   A  DGRLK  D+++ +N   +   +TH  A+++L+ A  TV+LVI 
Sbjct: 1618 RIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN-MTHTDAVNLLRAASKTVRLVIG 1675

Query: 222  RG-SLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT--- 277
            R   LP++                    P+    +  I L  +   LGF + GG  +   
Sbjct: 1676 RVLELPRI--------------------PMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ 1715

Query: 278  GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322
             V +  I P  VA   G L   D I  +      GM+ E+V + L
Sbjct: 1716 VVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL 1760



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 37/134 (27%), Positives = 68/134 (50%), Gaps = 13/134 (9%)

Query: 372  ESETFDVELTKNVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
            E E   V L K+ + GLG  I G     +L+  GIF+ S+      + DG ++ GD++I+
Sbjct: 897  EREITLVNLKKDAKYGLGFQIIGGEKMGRLD-LGIFISSVAPGGPADLDGCLKPGDRLIS 955

Query: 431  VDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASII 490
            V+  +L+G ++  A+E+L++  + V L +      Q  E +S+   T      PV+ +  
Sbjct: 956  VNSVSLEGVSHHAAIEILQNAPEDVTLVI-----SQPKEKISKVPST------PVHLTNE 1004

Query: 491  KENYEKDEDFLSST 504
             +NY K   ++  +
Sbjct: 1005 MKNYMKKSSYMQDS 1018



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 14/111 (12%)

Query: 528 EDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH---------FI 578
           +DAQ  +  L  +W  +     EI + ++ K ++  GLG  +   +G           FI
Sbjct: 878 QDAQDIDV-LHKRWSIVSSPEREITLVNLKKDAKY-GLGFQI---IGGEKMGRLDLGIFI 932

Query: 579 RSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
            SV P GP    G L  GD L+ VN ++L G +H   + IL+  P +VT+V
Sbjct: 933 SSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV 983



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 31/82 (37%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1959 ITLERGPDG-LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
            ITL +   G LGF++  G    +  +  YV  V    A S DGRLK GD++I VN   + 
Sbjct: 1598 ITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVT 1652

Query: 2018 GVTHEEAVAILKRTKGTVTLMV 2039
             +TH +AV +L+    TV L++
Sbjct: 1653 NMTHTDAVNLLRAASKTVRLVI 1674



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 31/138 (22%), Positives = 57/138 (41%), Gaps = 18/138 (13%)

Query: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNA----- 1414
            LG SL G  D     V+I  I+P   A  +G LQ+ D +  +NG    G + +       
Sbjct: 1702 LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALD 1761

Query: 1415 ----SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSD 1470
                S ++K   + + ++    + AV+      GN    + S S        +P +T +D
Sbjct: 1762 MSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS--------QPALTPND 1813

Query: 1471 AAVDLSSFKNVQHLELPK 1488
            +   ++  + +  +  PK
Sbjct: 1814 SFSTVAG-EEINEISYPK 1830


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score =  139 bits (350), Expect = 3e-32
 Identities = 146/581 (25%), Positives = 238/581 (40%), Gaps = 125/581 (21%)

Query: 133  RHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
            R + +  L K    GLGF ++G     R +LGIF+  +  G  A  DG LK  D+++++N
Sbjct: 1089 REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1148

Query: 193  GQALDQTITHQQAISILQKAKDTVQLVIARG--------SLP-----QLVSPIVSRSPSA 239
              +L+  ++H  AI ILQ A + V LVI++         S P     ++ + +   S   
Sbjct: 1149 SVSLEG-VSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ 1207

Query: 240  ASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSG 299
             S I + S   HW    T+  +++ S   FG  GG         +  G ++ Q  R  S 
Sbjct: 1208 DSAIDSSSKDHHWSR-GTLRHISENS---FGPSGG---------LREGSLSSQDSRTESA 1254

Query: 300  DHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITL-------- 351
                   +   A    +Q  Q   Q G+    +I++   +E    +    T         
Sbjct: 1255 SLSQSQVNGFFASHLGDQTWQE-SQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1313

Query: 352  ----------------SSSPTSTPELRVDASTQKGEE-------------SETFDVELTK 382
                            SS    TP+    +S     +              + F+VEL K
Sbjct: 1314 DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK 1373

Query: 383  NVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQ 442
            N   LGI++ G + +  +   GI+VK++    A E DGRI  GD+++AV+G +L+G T++
Sbjct: 1374 NDNSLGISVTGGV-NTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1432

Query: 443  QAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLS 502
            QAVE LR+TGQ V L L+ +G                                       
Sbjct: 1433 QAVETLRNTGQVVHL-LLEKGQS------------------------------------- 1454

Query: 503  STRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY--EIVVAHVSKFS 560
                    PT +E  P+        ++AQ Q    + K  ++   ++  E     V  F 
Sbjct: 1455 --------PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFK 1506

Query: 561  ENSGLGISL---------EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
             +SGLG S          +       ++ + P  P   SGK+  GD +L+VNG +L G +
Sbjct: 1507 NSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1566

Query: 612  HQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIE 652
             Q+V++ L+    EV ++ CR   PP    E+D+  L  ++
Sbjct: 1567 QQEVISALRGTAPEVFLLLCR--PPPGVLPEIDTALLTPLQ 1605



 Score =  129 bits (325), Expect = 2e-29
 Identities = 152/615 (24%), Positives = 247/615 (40%), Gaps = 101/615 (16%)

Query: 1250 PLPSLLHNLYPKYNFSSTNPFADSL----QINADKAPSQSESEPEK----APLCSVPPPP 1301
            P P  +  L  K +   +   A+SL    ++N  K+ +     PE+    +   S+  P 
Sbjct: 991  PPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPG 1050

Query: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS-GL 1360
             +    M    + +S+S++   + + D     W  +     +   E+ ++ L+K    GL
Sbjct: 1051 QAYVLGMTMHSSGNSSSQVP--LKENDVLHKRWSIV----SSPEREITLVNLKKDAKYGL 1104

Query: 1361 GLSLAGNKDRSRMS--VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSII 1418
            G  + G +   R+   +FI  + P G A  DG L+  D L+ +N   L G SH  A  I+
Sbjct: 1105 GFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEIL 1164

Query: 1419 KCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSF 1478
            + AP  V ++  + K+ ++++   P +    L +  +N   K +       D+A+D SS 
Sbjct: 1165 QNAPEDVTLVISQPKEKISKVPSTPVH----LTNEMKNYMKKSSY----MQDSAIDSSSK 1216

Query: 1479 KN------VQHLELPK--DQGGL--GIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQ 1528
             +      ++H+        GGL  G   S++       +     +G  A+     +GDQ
Sbjct: 1217 DHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASH----LGDQ 1272

Query: 1529 ILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQ-- 1586
                  E   G P    IS     K T K T    N      P  +       +  S   
Sbjct: 1273 TW---QESQHGSPSPSVIS-----KATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMD 1324

Query: 1587 -----SLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGL 1641
                 S    Q+   E  S  NTS       F+S P      PG    +E++K    LG+
Sbjct: 1325 EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPK----PGDIFEVELAKNDNSLGI 1380

Query: 1642 SIVGGSDTLL--GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ 1699
            S+ GG +T +  G I +  V  +GAA  DGR+  GD++L VNG+ L  ATH +A+  LR 
Sbjct: 1381 SVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN 1440

Query: 1700 TPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK---------------- 1743
            T Q V L L + ++P  +E V  T    L  +  +G G   V K                
Sbjct: 1441 TGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTF 1500

Query: 1744 -----RNDTG--------------------VFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
                 +N +G                    V V  +  G  A   G++  GD IL VNG 
Sbjct: 1501 EVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGA 1560

Query: 1779 DVRNATQEAVAALLK 1793
             ++  +Q+ V + L+
Sbjct: 1561 SLKGLSQQEVISALR 1575



 Score =  121 bits (304), Expect = 6e-27
 Identities = 228/1034 (22%), Positives = 380/1034 (36%), Gaps = 221/1034 (21%)

Query: 1090 PAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQP 1149
            P     E   S  +  G+   L +    +G    ++P +E      +++ +  +S  + P
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKE------NDVLHKRWSIVSSP 1087

Query: 1150 RR----VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPG 1205
             R    V L ++    LG  I+GG  MG       +  GIFI  V    PA  +G LKPG
Sbjct: 1088 EREITLVNLKKDAKYGLGFQIIGGEKMG------RLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 1206 DRI-----VEVDGMD-------LRDASHE------QAVEAIRKAGNPVVFMVQSIINRPR 1247
            DR+     V ++G+        L++A  +      Q  E I K  +  V +   + N  +
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMK 1201

Query: 1248 KSPL--PSLLHNLYPKYNFS-------STNPFADSLQINADKAPSQSESEPEKAPLCSVP 1298
            KS     S + +    +++S       S N F  S  +      SQ +S  E A L    
Sbjct: 1202 KSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQ-DSRTESASLSQSQ 1260

Query: 1299 --------------------PPPPSAFA-----EMGSDHTQSSASK-------------- 1319
                                 P PS  +     E  +D  QS   K              
Sbjct: 1261 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1320

Query: 1320 ---------ISQDVDKEDEFGYSWKNIRERYGTLT--------GELHMIELEKGHSGLGL 1362
                      SQD     +   S  N   +    T        G++  +EL K  + LG+
Sbjct: 1321 SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGI 1380

Query: 1363 SLAGNKDRS--RMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKC 1420
            S+ G  + S     +++  + P GAA  DGR+   D +L +NG  L G +H+ A   ++ 
Sbjct: 1381 SVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN 1440

Query: 1421 APSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKN 1480
                V ++  + +   ++  V           N++    ++ + T    D +    + +N
Sbjct: 1441 TGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--FVTEEN 1498

Query: 1481 VQHLELPKDQGGLGIAISEEDTL-------SGVIIKSLTEHGVAATDGRLKVGDQILAVD 1533
               ++L K+  GLG + S ED L       S V +K L     AA  G++ VGD IL V+
Sbjct: 1499 TFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVN 1558

Query: 1534 DEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQS 1593
               + G   ++ IS L+     V L +    P    +P    A     ++ +Q L     
Sbjct: 1559 GASLKGLSQQEVISALRGTAPEVFLLLC--RPPPGVLPEIDTALLTPLQSPAQVLPNSSK 1616

Query: 1594 GSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGA 1653
             S +P  +  ++ S    +       C   P    +   S G          G D L+ A
Sbjct: 1617 DSSQPSCVEQSTSSDENEMSDKSKKQCKS-PSRRDSYSDSSG---------SGEDDLVTA 1666

Query: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA 1713
                       A      W+              A H    N++ Q            EA
Sbjct: 1667 ----------PANISNSTWSS-------------ALHQTLSNMVSQAQSH-------HEA 1696

Query: 1714 PYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQIL 1773
            P  +E+   T+    QK P K                          D++   +  D   
Sbjct: 1697 PKSQEDTICTMFYYPQKIPNKP----------------------EFEDSNPSPLPPD--- 1731

Query: 1774 MVNGEDVRNATQEAVAALL-KVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLR 1832
            M  G+  +  ++ A ++ + K     +S  T   + +     LE+  +   L  E+  + 
Sbjct: 1732 MAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELL-IT 1790

Query: 1833 TVEMKKGPTDSLGISIAGG---VGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICG 1889
             ++ +KG   SLG ++  G   +G  + DV     +  P   A    +L+ GDR++ +  
Sbjct: 1791 LIKSEKG---SLGFTVTKGNQRIGCYVHDV-----IQDP---AKSDGRLKPGDRLIKVND 1839

Query: 1890 TSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQD 1949
            T    MTHT AVNLL+ AS ++ +          V G   E               + + 
Sbjct: 1840 TDVTNMTHTDAVNLLRAASKTVRL----------VIGRVLE---------------LPRI 1874

Query: 1950 DLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQII 2009
             + P     ITL    + LGFS+ GG+ S +    +Y+  +  +  A+ +G L+  D I 
Sbjct: 1875 PMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ--VVYISDINPRSVAAIEGNLQLLDVIH 1932

Query: 2010 AVNGQSLEGVTHEE 2023
             VNG S +G+T EE
Sbjct: 1933 YVNGVSTQGMTLEE 1946



 Score =  110 bits (276), Expect = 1e-23
 Identities = 178/885 (20%), Positives = 340/885 (38%), Gaps = 172/885 (19%)

Query: 266  GLGFGIIGGKATG-----VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
            GLGF IIGG+  G     + + ++ PGG AD  G L  GD ++ +    L G+S     +
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 321  VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTS-TPELRVDASTQKGEESETFDVE 379
            +L+     V L+I++   +    P        S+P   T E++         +    D  
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVP--------STPVHLTNEMKNYMKKSSYMQDSAIDSS 1214

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
               +    G     +I +    PSG     + + S    D R +      ++  + + GF
Sbjct: 1215 SKDHHWSRGTL--RHISENSFGPSG----GLREGSLSSQDSRTESA----SLSQSQVNGF 1264

Query: 440  ----TNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYE 495
                   Q  +  +H   +   +++ +  ++E    S +  TK   +S V     + + +
Sbjct: 1265 FASHLGDQTWQESQHGSPSP--SVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSD 1322

Query: 496  KDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAH 555
             DE   SS+++    P +E            +  + K      +      G  +E+ +A 
Sbjct: 1323 MDEATYSSSQDHQT-PKQESS--------SSVNTSNKMNFKTFSSSPPKPGDIFEVELA- 1372

Query: 556  VSKFSENSGLGISLEATV------GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
                  ++ LGIS+   V      G  ++++V+P+G     G++  GD +L VNG++L G
Sbjct: 1373 ----KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428

Query: 610  ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669
              H+  V  L+    +V  +   +   PT++  +     C +               +++
Sbjct: 1429 ATHKQAVETLRNTG-QVVHLLLEKGQSPTSKEHVPVTPQCTLS------------DQNAQ 1475

Query: 670  TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL--DYQDPIDPASTV 727
             + P     +  + T +V+    + E     ++L K S GLGFS    D   P    +++
Sbjct: 1476 GQGP-----EKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1530

Query: 728  IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA-----------PS 776
            + ++ L PG  A + G++  GD ++ VN  +L+  S +E + AL+G            P 
Sbjct: 1531 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1590

Query: 777  GTV-RIGVAKPLPL-SPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDAD 834
            G +  I  A   PL SP +   ++ +DS      SC E                 +++ +
Sbjct: 1591 GVLPEIDTALLTPLQSPAQVLPNSSKDS---SQPSCVEQS-------------TSSDENE 1634

Query: 835  LVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVL 894
            + D+S  +       DS           +  S G G +   + P++       ++     
Sbjct: 1635 MSDKSKKQCKSPSRRDS-----------YSDSSGSGEDDLVTAPANISNSTWSSA----- 1678

Query: 895  DLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTE 954
             LH +L  + +Q     +                          A + Q +   T+ +  
Sbjct: 1679 -LHQTLSNMVSQAQSHHE--------------------------APKSQEDTICTMFYYP 1711

Query: 955  SHLPSEVISSAELPSVLPDSAGKGSEYLLE-QSSLACNAECVMLQNVSK----------- 1002
              +P++       PS LP     G  Y  + +S+ + + +   + ++S+           
Sbjct: 1712 QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLK 1771

Query: 1003 -------ESFERTIN-----IAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAI 1050
                   E FE  +      I     SLG TV+     +G  V  +I   A S DGR+  
Sbjct: 1772 NDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKS-DGRLKP 1830

Query: 1051 GDCILSINEESTISVTNAQARAMLRRHS-----LIGPDIKITYVP 1090
            GD ++ +N+    ++T+  A  +LR  S     +IG  +++  +P
Sbjct: 1831 GDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIP 1875



 Score =  103 bits (257), Expect = 2e-21
 Identities = 160/705 (22%), Positives = 274/705 (38%), Gaps = 140/705 (19%)

Query: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
            SLGIS+ GG  + + + +G    GI++K V+    A  +G +  GDR++ V+G+ L  A+
Sbjct: 1377 SLGISVTGG--VNTSVRHG----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGAT 1430

Query: 1221 HEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADK 1280
            H+QAVE +R  G  V                                      L +   +
Sbjct: 1431 HKQAVETLRNTGQVV-------------------------------------HLLLEKGQ 1453

Query: 1281 APSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRER 1340
            +P+  E          VP  P    ++  +        K+ +    +D    + +N  E 
Sbjct: 1454 SPTSKEH---------VPVTPQCTLSDQNAQG--QGPEKVKKTTQVKDYSFVTEENTFE- 1501

Query: 1341 YGTLTGELHMIELEKGHSGLGLSLA--GNKDRSRMSVFIVGID---PNGAAGKDGRLQIA 1395
                      ++L K  SGLG S +   N    +++  IV +    P   A + G++ + 
Sbjct: 1502 ----------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVG 1551

Query: 1396 DELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSE 1455
            D +L++NG  L G S Q   S ++    +V ++  R    V  +       + PL S ++
Sbjct: 1552 DVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGV--LPEIDTALLTPLQSPAQ 1609

Query: 1456 NLQNKE---TEPTVTTSDAAVDLS--SFKNVQHLELPK------DQGGLGIAISEEDTLS 1504
             L N     ++P+      + D +  S K+ +  + P       D  G G    E+D ++
Sbjct: 1610 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG----EDDLVT 1665

Query: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN 1564
                 S +    A       +  Q  +  +      P  +  ++        K+    E 
Sbjct: 1666 APANISNSTWSSALHQTLSNMVSQAQSHHEA-----PKSQEDTICTMFYYPQKIPNKPEF 1720

Query: 1565 PDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPAT----C 1620
             DS   P     A G            QS  P+ ES  ++S         S+P       
Sbjct: 1721 EDSNPSPLPPDMAPG------------QSYQPQSESASSSSMDKYHIHHISEPTRQENWT 1768

Query: 1621 PIIPGCETTIE------------ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKD 1668
            P+    E  +E            I   +  LG ++  G+  +     +H+V ++ A   D
Sbjct: 1769 PLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAK-SD 1825

Query: 1669 GRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR----DEAPYKEEEVCD-T 1723
            GRL  GD++++VN  D+   TH +A+N+LR   + VRL + R       P     + D T
Sbjct: 1826 GRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDIT 1885

Query: 1724 LTIELQKKPGKGLGLSIVGKRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
            LT   ++     LG S+ G  +     V++SDI    +A  +G L   D I  VNG   +
Sbjct: 1886 LTCNKEE-----LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1940

Query: 1782 NATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALAS 1826
              T E V   L +S  SL      L  +     +  SSK++A+++
Sbjct: 1941 GMTLEEVNRALDMSLPSL-----VLKATRNDLPVVPSSKRSAVSA 1980



 Score =  100 bits (249), Expect = 1e-20
 Identities = 75/269 (27%), Positives = 127/269 (47%), Gaps = 25/269 (9%)

Query: 258  IELVNDGSGLGFGIIGGKAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAG 312
            +EL  + + LG  + GG  T     G+ VK ++P G A+  GR+  GD +L +    L G
Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428

Query: 313  MSSEQVAQVLRQCGNRVKLMIARG--AIEERTAPTALGITLS--SSPTSTPELRVDASTQ 368
             + +Q  + LR  G  V L++ +G     +   P     TLS  ++    PE +V  +TQ
Sbjct: 1429 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE-KVKKTTQ 1487

Query: 369  KGE-----ESETFDVELTKNVQGLGITIA--GYIGDKKLEPSGIFVKSITKSSAVEHDGR 421
              +     E  TF+V+L KN  GLG + +    +  +++  S + VK +         G+
Sbjct: 1488 VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1547

Query: 422  IQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEAE------LMSR 473
            I +GD I+ V+G +L+G + Q+ +  LR T   V L L R   G+  E +      L S 
Sbjct: 1548 IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSP 1607

Query: 474  EDVTKDADLSPVNASIIKENYEKDEDFLS 502
              V  ++       S ++++   DE+ +S
Sbjct: 1608 AQVLPNSSKDSSQPSCVEQSTSSDENEMS 1636



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 164/730 (22%), Positives = 277/730 (37%), Gaps = 132/730 (18%)

Query: 136  EVFEL-LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
            ++FE+ L      LG SV G  + +    GI+V+ +     A  DGR+ + D++LA+NG 
Sbjct: 1365 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1424

Query: 195  ALDQTITHQQAISILQKAKDTVQLVIARGSLPQL-----VSPIVSRSPSAA--------- 240
            +L+   TH+QA+  L+     V L++ +G  P       V+P  + S   A         
Sbjct: 1425 SLEGA-THKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVK 1483

Query: 241  -STISAHSNPVHWQHMETIELVNDGSGLGFGIIGG--------KATGVIVKTILPGGVAD 291
             +T     + V  ++   ++L  + SGLGF              A+ V VK + PG  A 
Sbjct: 1484 KTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1543

Query: 292  QHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR---GAIEERTAPTALG 348
            + G++  GD ILK+    L G+S ++V   LR     V L++ R   G + E    TAL 
Sbjct: 1544 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPE--IDTALL 1601

Query: 349  ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVK 408
              L S     P    D+S     E  T   E   + +      +    D   + SG    
Sbjct: 1602 TPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED 1661

Query: 409  SITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEA 468
             +  + A      I       A+  T     +  Q+      + +  + T+     K   
Sbjct: 1662 DLVTAPA-----NISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQK--- 1713

Query: 469  ELMSREDVTKDADLSPVNASIIK-ENYEKDEDFLSSTRNTNI------LPTEEEGYPLLS 521
              +  +   +D++ SP+   +   ++Y+   +  SS+            PT +E +  L 
Sbjct: 1714 --IPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLK 1771

Query: 522  AEIE-EIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH---- 576
             ++E  +ED + +   L+T  +                 SE   LG ++  T G+     
Sbjct: 1772 NDLENHLEDFELEVELLITLIK-----------------SEKGSLGFTV--TKGNQRIGC 1812

Query: 577  FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVP 636
            ++  V+ + P    G+L  GD L++VN   +    H D VN+L+     V +V  R    
Sbjct: 1813 YVHDVI-QDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---- 1867

Query: 637  PTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEA 696
                     L+L  I +   PH+                                     
Sbjct: 1868 --------VLELPRIPML--PHL------------------------------------- 1880

Query: 697  GIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVND 756
             +  I L    + LGFS+    D +     V+ I  + P  +A  +G L   D + +VN 
Sbjct: 1881 -LPDITLTCNKEELGFSLCGGHDSL---YQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1936

Query: 757  VNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP--EEGYVSAKED---SFLYPPHSCE 811
            V+ +  +LEE   AL  +    V       LP+ P  +   VSA +    +  Y   SC 
Sbjct: 1937 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1996

Query: 812  EAGLADKPLF 821
            +  L     F
Sbjct: 1997 QPALTPNDSF 2006



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 119/509 (23%), Positives = 191/509 (37%), Gaps = 112/509 (22%)

Query: 1628 TTIEISK-GRTGLGLSIVGGSDT--LLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
            T + + K  + GLG  I+GG     L   I I  V   G A  DG L  GD+++ VN + 
Sbjct: 1092 TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 1151

Query: 1685 ------------LRKATHD---------EAINVLRQTPQRV--RLTLYRDEAPYKEEEVC 1721
                        L+ A  D         E I+ +  TP  +   +  Y  ++ Y ++   
Sbjct: 1152 LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI 1211

Query: 1722 DTLT-------------IELQKKPGKGL---GLSIVGKRNDTGVFVSDIVKGGIADADG- 1764
            D+ +              E    P  GL    LS    R ++       V G  A   G 
Sbjct: 1212 DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD 1271

Query: 1765 RLMQGDQILMVNGEDVRNATQEA-----------------VAALLKVSEGSLSSFTFPLS 1807
            +  Q  Q    +   +  AT++                  V       +  +   T+  S
Sbjct: 1272 QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS 1331

Query: 1808 GSSTSESLESSSKKNALASEIQGLRT-------------VEMKKGPTDSLGISIAGGVGS 1854
                +   ESSS  N   S     +T             VE+ K   +SLGIS+ GGV +
Sbjct: 1332 QDHQTPKQESSSSVNT--SNKMNFKTFSSSPPKPGDIFEVELAKND-NSLGISVTGGVNT 1388

Query: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQ 1914
             +    I++  + P G A    ++  GDR++ + G S EG TH QAV  L+N    + + 
Sbjct: 1389 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLL 1448

Query: 1915 VVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSIT-------------- 1960
            +  G      T  +  P +   + +   +        GP + K  T              
Sbjct: 1449 LEKG---QSPTSKEHVPVTPQCTLSDQNAQG-----QGPEKVKKTTQVKDYSFVTEENTF 1500

Query: 1961 ---LERGPDGLGFSIVGGYGSPHGDLP-------IYVKTVFAKGAASEDGRLKRGDQIIA 2010
               L +   GLGFS    +      +P       + VK +F    A+E G++  GD I+ 
Sbjct: 1501 EVKLFKNSSGLGFS----FSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1556

Query: 2011 VNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            VNG SL+G++ +E ++ L+ T   V L++
Sbjct: 1557 VNGASLKGLSQQEVISALRGTAPEVFLLL 1585



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 51/138 (36%), Positives = 67/138 (48%), Gaps = 20/138 (14%)

Query: 667  SSETEDP----VLAMTDAGQSTEEVQAPLA-------MW------EAGIQHIELEKGSK- 708
            SS  EDP    VL MT         Q PL         W      E  I  + L+K +K 
Sbjct: 1043 SSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKY 1102

Query: 709  GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAV 768
            GLGF I+   + +      I I S+ PGG A+ DG L PGDRL+ VN V+LE  S   A+
Sbjct: 1103 GLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAI 1161

Query: 769  EALKGAPSGTVRIGVAKP 786
            E L+ AP   V + +++P
Sbjct: 1162 EILQNAPE-DVTLVISQP 1178



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 40/225 (17%)

Query: 110  IPHINGKPACDEFDQLIKNMAQGRHVEVFEL--------LKPPSGGLGFSVVGLRSENRG 161
            I HI+ +P   E    +KN  +  H+E FEL        +K   G LGF+V    ++   
Sbjct: 1755 IHHIS-EPTRQENWTPLKNDLEN-HLEDFELEVELLITLIKSEKGSLGFTV----TKGNQ 1808

Query: 162  ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
             +G +V ++ +   A  DGRLK  D+++ +N   +   +TH  A+++L+ A  TV+LVI 
Sbjct: 1809 RIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN-MTHTDAVNLLRAASKTVRLVIG 1866

Query: 222  RG-SLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT--- 277
            R   LP++                    P+    +  I L  +   LGF + GG  +   
Sbjct: 1867 RVLELPRI--------------------PMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ 1906

Query: 278  GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322
             V +  I P  VA   G L   D I  +      GM+ E+V + L
Sbjct: 1907 VVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL 1951



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 52/200 (26%), Positives = 94/200 (47%), Gaps = 22/200 (11%)

Query: 314  SSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDA-------- 365
            +S+ VA  L +   R K      +IE+      LG+T+ SS  S+ ++ +          
Sbjct: 1023 NSKSVAS-LNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRW 1081

Query: 366  STQKGEESETFDVELTKNVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQI 424
            S     E E   V L K+ + GLG  I G     +L+  GIF+ S+      + DG ++ 
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLD-LGIFISSVAPGGPADLDGCLKP 1140

Query: 425  GDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSP 484
            GD++I+V+  +L+G ++  A+E+L++  + V L +      Q  E +S+   T      P
Sbjct: 1141 GDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI-----SQPKEKISKVPST------P 1189

Query: 485  VNASIIKENYEKDEDFLSST 504
            V+ +   +NY K   ++  +
Sbjct: 1190 VHLTNEMKNYMKKSSYMQDS 1209



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 37/156 (23%), Positives = 72/156 (46%), Gaps = 5/156 (3%)

Query: 1765 RLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS-----ESLESSS 1819
            +L     +  +N    R   +   +++    +  +   T   SG+S+S     E+     
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHK 1079

Query: 1820 KKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
            + + ++S  + +  V +KK     LG  I GG      D+ IFI+ + P G A     L+
Sbjct: 1080 RWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLK 1139

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQV 1915
             GDR++++   S EG++H  A+ +L+NA   + + +
Sbjct: 1140 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 27/177 (15%)

Query: 471  MSRED------VTK---DADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLS 521
            MSR D      VTK      ++ +N S  +  +E D   +       +L     G  + S
Sbjct: 1007 MSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVL-----GMTMHS 1061

Query: 522  AEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH----- 576
            +     +   K+   L  +W  +     EI + ++ K ++  GLG  +   +G       
Sbjct: 1062 SGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKY-GLGFQI---IGGEKMGRL 1117

Query: 577  ----FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
                FI SV P GP    G L  GD L+ VN ++L G +H   + IL+  P +VT+V
Sbjct: 1118 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV 1174



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 31/82 (37%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1959 ITLERGPDG-LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
            ITL +   G LGF++  G    +  +  YV  V    A S DGRLK GD++I VN   + 
Sbjct: 1789 ITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVT 1843

Query: 2018 GVTHEEAVAILKRTKGTVTLMV 2039
             +TH +AV +L+    TV L++
Sbjct: 1844 NMTHTDAVNLLRAASKTVRLVI 1865



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 31/138 (22%), Positives = 57/138 (41%), Gaps = 18/138 (13%)

Query: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNA----- 1414
            LG SL G  D     V+I  I+P   A  +G LQ+ D +  +NG    G + +       
Sbjct: 1893 LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALD 1952

Query: 1415 ----SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSD 1470
                S ++K   + + ++    + AV+      GN    + S S        +P +T +D
Sbjct: 1953 MSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS--------QPALTPND 2004

Query: 1471 AAVDLSSFKNVQHLELPK 1488
            +   ++  + +  +  PK
Sbjct: 2005 SFSTVAG-EEINEISYPK 2021


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score =  139 bits (350), Expect = 3e-32
 Identities = 146/581 (25%), Positives = 238/581 (40%), Gaps = 125/581 (21%)

Query: 133  RHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
            R + +  L K    GLGF ++G     R +LGIF+  +  G  A  DG LK  D+++++N
Sbjct: 1070 REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1129

Query: 193  GQALDQTITHQQAISILQKAKDTVQLVIARG--------SLP-----QLVSPIVSRSPSA 239
              +L+  ++H  AI ILQ A + V LVI++         S P     ++ + +   S   
Sbjct: 1130 SVSLEG-VSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ 1188

Query: 240  ASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSG 299
             S I + S   HW    T+  +++ S   FG  GG         +  G ++ Q  R  S 
Sbjct: 1189 DSAIDSSSKDHHWSR-GTLRHISENS---FGPSGG---------LREGSLSSQDSRTESA 1235

Query: 300  DHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITL-------- 351
                   +   A    +Q  Q   Q G+    +I++   +E    +    T         
Sbjct: 1236 SLSQSQVNGFFASHLGDQTWQE-SQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1294

Query: 352  ----------------SSSPTSTPELRVDASTQKGEE-------------SETFDVELTK 382
                            SS    TP+    +S     +              + F+VEL K
Sbjct: 1295 DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK 1354

Query: 383  NVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQ 442
            N   LGI++ G + +  +   GI+VK++    A E DGRI  GD+++AV+G +L+G T++
Sbjct: 1355 NDNSLGISVTGGV-NTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHK 1413

Query: 443  QAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLS 502
            QAVE LR+TGQ V L L+ +G                                       
Sbjct: 1414 QAVETLRNTGQVVHL-LLEKGQS------------------------------------- 1435

Query: 503  STRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY--EIVVAHVSKFS 560
                    PT +E  P+        ++AQ Q    + K  ++   ++  E     V  F 
Sbjct: 1436 --------PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFK 1487

Query: 561  ENSGLGISL---------EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
             +SGLG S          +       ++ + P  P   SGK+  GD +L+VNG +L G +
Sbjct: 1488 NSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1547

Query: 612  HQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIE 652
             Q+V++ L+    EV ++ CR   PP    E+D+  L  ++
Sbjct: 1548 QQEVISALRGTAPEVFLLLCR--PPPGVLPEIDTALLTPLQ 1586



 Score =  127 bits (319), Expect = 1e-28
 Identities = 134/510 (26%), Positives = 208/510 (40%), Gaps = 87/510 (17%)

Query: 1347 ELHMIELEKGHS-GLGLSLAGNKDRSRMS--VFIVGIDPNGAAGKDGRLQIADELLEING 1403
            E+ ++ L+K    GLG  + G +   R+   +FI  + P G A  DG L+  D L+ +N 
Sbjct: 1071 EITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNS 1130

Query: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
              L G SH  A  I++ AP  V ++  + K+ ++++   P +    L +  +N   K + 
Sbjct: 1131 VSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVH----LTNEMKNYMKKSSY 1186

Query: 1464 PTVTTSDAAVDLSSFKN------VQHLELPK--DQGGL--GIAISEEDTLSGVIIKSLTE 1513
                  D+A+D SS  +      ++H+        GGL  G   S++       +     
Sbjct: 1187 ----MQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQV 1242

Query: 1514 HGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSA 1573
            +G  A+     +GDQ      E   G P    IS     K T K T    N      P  
Sbjct: 1243 NGFFASH----LGDQTW---QESQHGSPSPSVIS-----KATEKETFTDSNQSKTKKPGI 1290

Query: 1574 AGAASGEKKNSSQ-------SLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGC 1626
            +       +  S        S    Q+   E  S  NTS       F+S P      PG 
Sbjct: 1291 SDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPK----PGD 1346

Query: 1627 ETTIEISKGRTGLGLSIVGGSDTLL--GAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
               +E++K    LG+S+ GG +T +  G I +  V  +GAA  DGR+  GD++L VNG+ 
Sbjct: 1347 IFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1406

Query: 1685 LRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK- 1743
            L  ATH +A+  LR T Q V L L + ++P  +E V  T    L  +  +G G   V K 
Sbjct: 1407 LEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKT 1466

Query: 1744 --------------------RNDTG--------------------VFVSDIVKGGIADAD 1763
                                +N +G                    V V  +  G  A   
Sbjct: 1467 TQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAES 1526

Query: 1764 GRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
            G++  GD IL VNG  ++  +Q+ V + L+
Sbjct: 1527 GKIDVGDVILKVNGASLKGLSQQEVISALR 1556



 Score =  122 bits (306), Expect = 4e-27
 Identities = 225/1009 (22%), Positives = 371/1009 (36%), Gaps = 226/1009 (22%)

Query: 1126 PEREEGEGEESELQNTA--------YSNWN---QPRR----VELWREPSKSLGISIVGGR 1170
            PER + E + S +++          +  W+    P R    V L ++    LG  I+GG 
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGE 1093

Query: 1171 GMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRI-----VEVDGMD-------LRD 1218
             MG       +  GIFI  V    PA  +G LKPGDR+     V ++G+        L++
Sbjct: 1094 KMG------RLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQN 1147

Query: 1219 ASHE------QAVEAIRKAGNPVVFMVQSIINRPRKSPL--PSLLHNLYPKYNFS----- 1265
            A  +      Q  E I K  +  V +   + N  +KS     S + +    +++S     
Sbjct: 1148 APEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLR 1207

Query: 1266 --STNPFADSLQINADKAPSQSESEPEKAPLCSVP--------------------PPPPS 1303
              S N F  S  +      SQ +S  E A L                         P PS
Sbjct: 1208 HISENSFGPSGGLREGSLSSQ-DSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPS 1266

Query: 1304 AFA-----EMGSDHTQSSASK-----------------------ISQDVDKEDEFGYSWK 1335
              +     E  +D  QS   K                        SQD     +   S  
Sbjct: 1267 VISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSV 1326

Query: 1336 NIRERYGTLT--------GELHMIELEKGHSGLGLSLAGNKDRS--RMSVFIVGIDPNGA 1385
            N   +    T        G++  +EL K  + LG+S+ G  + S     +++  + P GA
Sbjct: 1327 NTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGA 1386

Query: 1386 AGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN 1445
            A  DGR+   D +L +NG  L G +H+ A   ++     V ++  + +   ++  V    
Sbjct: 1387 AESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTP 1446

Query: 1446 AVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL-- 1503
                   N++    ++ + T    D +    + +N   ++L K+  GLG + S ED L  
Sbjct: 1447 QCTLSDQNAQGQGPEKVKKTTQVKDYS--FVTEENTFEVKLFKNSSGLGFSFSREDNLIP 1504

Query: 1504 -----SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKL 1558
                 S V +K L     AA  G++ VGD IL V+   + G   ++ IS L+     V L
Sbjct: 1505 EQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFL 1564

Query: 1559 TIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPA 1618
             +    P    +P    A     ++ +Q L      S +P  +  ++ S    +      
Sbjct: 1565 LLC--RPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKK 1622

Query: 1619 TCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678
             C   P    +   S G          G D L+ A           A      W+     
Sbjct: 1623 QCKS-PSRRDSYSDSSG---------SGEDDLVTA----------PANISNSTWSS---- 1658

Query: 1679 EVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGL 1738
                     A H    N++ Q            EAP  +E+   T+    QK P K    
Sbjct: 1659 ---------ALHQTLSNMVSQAQSH-------HEAPKSQEDTICTMFYYPQKIPNKP--- 1699

Query: 1739 SIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL-KVSEG 1797
                                  D++   +  D   M  G+  +  ++ A ++ + K    
Sbjct: 1700 -------------------EFEDSNPSPLPPD---MAPGQSYQPQSESASSSSMDKYHIH 1737

Query: 1798 SLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGG---VGS 1854
             +S  T   + +     LE+  +   L  E+  +  ++ +KG   SLG ++  G   +G 
Sbjct: 1738 HISEPTRQENWTPLKNDLENHLEDFELEVELL-ITLIKSEKG---SLGFTVTKGNQRIGC 1793

Query: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQ 1914
             + DV     +  P   A    +L+ GDR++ +  T    MTHT AVNLL+ AS ++ + 
Sbjct: 1794 YVHDV-----IQDP---AKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRL- 1844

Query: 1915 VVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVG 1974
                     V G   E               + +  + P     ITL    + LGFS+ G
Sbjct: 1845 ---------VIGRVLE---------------LPRIPMLPHLLPDITLTCNKEELGFSLCG 1880

Query: 1975 GYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEE 2023
            G+ S +    +Y+  +  +  A+ +G L+  D I  VNG S +G+T EE
Sbjct: 1881 GHDSLYQ--VVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEE 1927



 Score =  110 bits (276), Expect = 1e-23
 Identities = 178/885 (20%), Positives = 340/885 (38%), Gaps = 172/885 (19%)

Query: 266  GLGFGIIGGKATG-----VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
            GLGF IIGG+  G     + + ++ PGG AD  G L  GD ++ +    L G+S     +
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143

Query: 321  VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTS-TPELRVDASTQKGEESETFDVE 379
            +L+     V L+I++   +    P        S+P   T E++         +    D  
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISKVP--------STPVHLTNEMKNYMKKSSYMQDSAIDSS 1195

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
               +    G     +I +    PSG     + + S    D R +      ++  + + GF
Sbjct: 1196 SKDHHWSRGTL--RHISENSFGPSG----GLREGSLSSQDSRTESA----SLSQSQVNGF 1245

Query: 440  ----TNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYE 495
                   Q  +  +H   +   +++ +  ++E    S +  TK   +S V     + + +
Sbjct: 1246 FASHLGDQTWQESQHGSPSP--SVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSD 1303

Query: 496  KDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAH 555
             DE   SS+++    P +E            +  + K      +      G  +E+ +A 
Sbjct: 1304 MDEATYSSSQDHQT-PKQESS--------SSVNTSNKMNFKTFSSSPPKPGDIFEVELA- 1353

Query: 556  VSKFSENSGLGISLEATV------GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLG 609
                  ++ LGIS+   V      G  ++++V+P+G     G++  GD +L VNG++L G
Sbjct: 1354 ----KNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409

Query: 610  ENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSE 669
              H+  V  L+    +V  +   +   PT++  +     C +               +++
Sbjct: 1410 ATHKQAVETLRNTG-QVVHLLLEKGQSPTSKEHVPVTPQCTLS------------DQNAQ 1456

Query: 670  TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL--DYQDPIDPASTV 727
             + P     +  + T +V+    + E     ++L K S GLGFS    D   P    +++
Sbjct: 1457 GQGP-----EKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASI 1511

Query: 728  IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA-----------PS 776
            + ++ L PG  A + G++  GD ++ VN  +L+  S +E + AL+G            P 
Sbjct: 1512 VRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPP 1571

Query: 777  GTV-RIGVAKPLPL-SPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDAD 834
            G +  I  A   PL SP +   ++ +DS      SC E                 +++ +
Sbjct: 1572 GVLPEIDTALLTPLQSPAQVLPNSSKDS---SQPSCVEQS-------------TSSDENE 1615

Query: 835  LVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCDPVL 894
            + D+S  +       DS           +  S G G +   + P++       ++     
Sbjct: 1616 MSDKSKKQCKSPSRRDS-----------YSDSSGSGEDDLVTAPANISNSTWSSA----- 1659

Query: 895  DLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIVWTE 954
             LH +L  + +Q     +                          A + Q +   T+ +  
Sbjct: 1660 -LHQTLSNMVSQAQSHHE--------------------------APKSQEDTICTMFYYP 1692

Query: 955  SHLPSEVISSAELPSVLPDSAGKGSEYLLE-QSSLACNAECVMLQNVSK----------- 1002
              +P++       PS LP     G  Y  + +S+ + + +   + ++S+           
Sbjct: 1693 QKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLK 1752

Query: 1003 -------ESFERTIN-----IAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAI 1050
                   E FE  +      I     SLG TV+     +G  V  +I   A S DGR+  
Sbjct: 1753 NDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKS-DGRLKP 1811

Query: 1051 GDCILSINEESTISVTNAQARAMLRRHS-----LIGPDIKITYVP 1090
            GD ++ +N+    ++T+  A  +LR  S     +IG  +++  +P
Sbjct: 1812 GDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIP 1856



 Score =  103 bits (257), Expect = 2e-21
 Identities = 160/705 (22%), Positives = 274/705 (38%), Gaps = 140/705 (19%)

Query: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
            SLGIS+ GG  + + + +G    GI++K V+    A  +G +  GDR++ V+G+ L  A+
Sbjct: 1358 SLGISVTGG--VNTSVRHG----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGAT 1411

Query: 1221 HEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADK 1280
            H+QAVE +R  G  V                                      L +   +
Sbjct: 1412 HKQAVETLRNTGQVV-------------------------------------HLLLEKGQ 1434

Query: 1281 APSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRER 1340
            +P+  E          VP  P    ++  +        K+ +    +D    + +N  E 
Sbjct: 1435 SPTSKEH---------VPVTPQCTLSDQNAQG--QGPEKVKKTTQVKDYSFVTEENTFE- 1482

Query: 1341 YGTLTGELHMIELEKGHSGLGLSLA--GNKDRSRMSVFIVGID---PNGAAGKDGRLQIA 1395
                      ++L K  SGLG S +   N    +++  IV +    P   A + G++ + 
Sbjct: 1483 ----------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVG 1532

Query: 1396 DELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSE 1455
            D +L++NG  L G S Q   S ++    +V ++  R    V  +       + PL S ++
Sbjct: 1533 DVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGV--LPEIDTALLTPLQSPAQ 1590

Query: 1456 NLQNKE---TEPTVTTSDAAVDLS--SFKNVQHLELPK------DQGGLGIAISEEDTLS 1504
             L N     ++P+      + D +  S K+ +  + P       D  G G    E+D ++
Sbjct: 1591 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG----EDDLVT 1646

Query: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN 1564
                 S +    A       +  Q  +  +      P  +  ++        K+    E 
Sbjct: 1647 APANISNSTWSSALHQTLSNMVSQAQSHHEA-----PKSQEDTICTMFYYPQKIPNKPEF 1701

Query: 1565 PDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPAT----C 1620
             DS   P     A G            QS  P+ ES  ++S         S+P       
Sbjct: 1702 EDSNPSPLPPDMAPG------------QSYQPQSESASSSSMDKYHIHHISEPTRQENWT 1749

Query: 1621 PIIPGCETTIE------------ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKD 1668
            P+    E  +E            I   +  LG ++  G+  +     +H+V ++ A   D
Sbjct: 1750 PLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAK-SD 1806

Query: 1669 GRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR----DEAPYKEEEVCD-T 1723
            GRL  GD++++VN  D+   TH +A+N+LR   + VRL + R       P     + D T
Sbjct: 1807 GRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDIT 1866

Query: 1724 LTIELQKKPGKGLGLSIVGKRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
            LT   ++     LG S+ G  +     V++SDI    +A  +G L   D I  VNG   +
Sbjct: 1867 LTCNKEE-----LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQ 1921

Query: 1782 NATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALAS 1826
              T E V   L +S  SL      L  +     +  SSK++A+++
Sbjct: 1922 GMTLEEVNRALDMSLPSL-----VLKATRNDLPVVPSSKRSAVSA 1961



 Score =  100 bits (249), Expect = 1e-20
 Identities = 75/269 (27%), Positives = 127/269 (47%), Gaps = 25/269 (9%)

Query: 258  IELVNDGSGLGFGIIGGKAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAG 312
            +EL  + + LG  + GG  T     G+ VK ++P G A+  GR+  GD +L +    L G
Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409

Query: 313  MSSEQVAQVLRQCGNRVKLMIARG--AIEERTAPTALGITLS--SSPTSTPELRVDASTQ 368
             + +Q  + LR  G  V L++ +G     +   P     TLS  ++    PE +V  +TQ
Sbjct: 1410 ATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE-KVKKTTQ 1468

Query: 369  KGE-----ESETFDVELTKNVQGLGITIA--GYIGDKKLEPSGIFVKSITKSSAVEHDGR 421
              +     E  TF+V+L KN  GLG + +    +  +++  S + VK +         G+
Sbjct: 1469 VKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGK 1528

Query: 422  IQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEAE------LMSR 473
            I +GD I+ V+G +L+G + Q+ +  LR T   V L L R   G+  E +      L S 
Sbjct: 1529 IDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSP 1588

Query: 474  EDVTKDADLSPVNASIIKENYEKDEDFLS 502
              V  ++       S ++++   DE+ +S
Sbjct: 1589 AQVLPNSSKDSSQPSCVEQSTSSDENEMS 1617



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 164/730 (22%), Positives = 277/730 (37%), Gaps = 132/730 (18%)

Query: 136  EVFEL-LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
            ++FE+ L      LG SV G  + +    GI+V+ +     A  DGR+ + D++LA+NG 
Sbjct: 1346 DIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGV 1405

Query: 195  ALDQTITHQQAISILQKAKDTVQLVIARGSLPQL-----VSPIVSRSPSAA--------- 240
            +L+   TH+QA+  L+     V L++ +G  P       V+P  + S   A         
Sbjct: 1406 SLEGA-THKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVK 1464

Query: 241  -STISAHSNPVHWQHMETIELVNDGSGLGFGIIGG--------KATGVIVKTILPGGVAD 291
             +T     + V  ++   ++L  + SGLGF              A+ V VK + PG  A 
Sbjct: 1465 KTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1524

Query: 292  QHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR---GAIEERTAPTALG 348
            + G++  GD ILK+    L G+S ++V   LR     V L++ R   G + E    TAL 
Sbjct: 1525 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPE--IDTALL 1582

Query: 349  ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVK 408
              L S     P    D+S     E  T   E   + +      +    D   + SG    
Sbjct: 1583 TPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGED 1642

Query: 409  SITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEA 468
             +  + A      I       A+  T     +  Q+      + +  + T+     K   
Sbjct: 1643 DLVTAPA-----NISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQK--- 1694

Query: 469  ELMSREDVTKDADLSPVNASIIK-ENYEKDEDFLSSTRNTNI------LPTEEEGYPLLS 521
              +  +   +D++ SP+   +   ++Y+   +  SS+            PT +E +  L 
Sbjct: 1695 --IPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLK 1752

Query: 522  AEIE-EIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH---- 576
             ++E  +ED + +   L+T  +                 SE   LG ++  T G+     
Sbjct: 1753 NDLENHLEDFELEVELLITLIK-----------------SEKGSLGFTV--TKGNQRIGC 1793

Query: 577  FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVP 636
            ++  V+ + P    G+L  GD L++VN   +    H D VN+L+     V +V  R    
Sbjct: 1794 YVHDVI-QDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGR---- 1848

Query: 637  PTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEA 696
                     L+L  I +   PH+                                     
Sbjct: 1849 --------VLELPRIPML--PHL------------------------------------- 1861

Query: 697  GIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVND 756
             +  I L    + LGFS+    D +     V+ I  + P  +A  +G L   D + +VN 
Sbjct: 1862 -LPDITLTCNKEELGFSLCGGHDSL---YQVVYISDINPRSVAAIEGNLQLLDVIHYVNG 1917

Query: 757  VNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP--EEGYVSAKED---SFLYPPHSCE 811
            V+ +  +LEE   AL  +    V       LP+ P  +   VSA +    +  Y   SC 
Sbjct: 1918 VSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS 1977

Query: 812  EAGLADKPLF 821
            +  L     F
Sbjct: 1978 QPALTPNDSF 1987



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 119/509 (23%), Positives = 191/509 (37%), Gaps = 112/509 (22%)

Query: 1628 TTIEISK-GRTGLGLSIVGGSDT--LLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
            T + + K  + GLG  I+GG     L   I I  V   G A  DG L  GD+++ VN + 
Sbjct: 1073 TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 1132

Query: 1685 ------------LRKATHD---------EAINVLRQTPQRV--RLTLYRDEAPYKEEEVC 1721
                        L+ A  D         E I+ +  TP  +   +  Y  ++ Y ++   
Sbjct: 1133 LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI 1192

Query: 1722 DTLT-------------IELQKKPGKGL---GLSIVGKRNDTGVFVSDIVKGGIADADG- 1764
            D+ +              E    P  GL    LS    R ++       V G  A   G 
Sbjct: 1193 DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD 1252

Query: 1765 RLMQGDQILMVNGEDVRNATQEA-----------------VAALLKVSEGSLSSFTFPLS 1807
            +  Q  Q    +   +  AT++                  V       +  +   T+  S
Sbjct: 1253 QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS 1312

Query: 1808 GSSTSESLESSSKKNALASEIQGLRT-------------VEMKKGPTDSLGISIAGGVGS 1854
                +   ESSS  N   S     +T             VE+ K   +SLGIS+ GGV +
Sbjct: 1313 QDHQTPKQESSSSVNT--SNKMNFKTFSSSPPKPGDIFEVELAKND-NSLGISVTGGVNT 1369

Query: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQ 1914
             +    I++  + P G A    ++  GDR++ + G S EG TH QAV  L+N    + + 
Sbjct: 1370 SVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLL 1429

Query: 1915 VVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSIT-------------- 1960
            +  G      T  +  P +   + +   +        GP + K  T              
Sbjct: 1430 LEKG---QSPTSKEHVPVTPQCTLSDQNAQG-----QGPEKVKKTTQVKDYSFVTEENTF 1481

Query: 1961 ---LERGPDGLGFSIVGGYGSPHGDLP-------IYVKTVFAKGAASEDGRLKRGDQIIA 2010
               L +   GLGFS    +      +P       + VK +F    A+E G++  GD I+ 
Sbjct: 1482 EVKLFKNSSGLGFS----FSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1537

Query: 2011 VNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            VNG SL+G++ +E ++ L+ T   V L++
Sbjct: 1538 VNGASLKGLSQQEVISALRGTAPEVFLLL 1566



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 38/93 (40%), Positives = 54/93 (58%), Gaps = 3/93 (3%)

Query: 695  EAGIQHIELEKGSK-GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMF 753
            E  I  + L+K +K GLGF I+   + +      I I S+ PGG A+ DG L PGDRL+ 
Sbjct: 1069 EREITLVNLKKDAKYGLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLIS 1127

Query: 754  VNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786
            VN V+LE  S   A+E L+ AP   V + +++P
Sbjct: 1128 VNSVSLEGVSHHAAIEILQNAPE-DVTLVISQP 1159



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 40/225 (17%)

Query: 110  IPHINGKPACDEFDQLIKNMAQGRHVEVFEL--------LKPPSGGLGFSVVGLRSENRG 161
            I HI+ +P   E    +KN  +  H+E FEL        +K   G LGF+V    ++   
Sbjct: 1736 IHHIS-EPTRQENWTPLKNDLEN-HLEDFELEVELLITLIKSEKGSLGFTV----TKGNQ 1789

Query: 162  ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
             +G +V ++ +   A  DGRLK  D+++ +N   +   +TH  A+++L+ A  TV+LVI 
Sbjct: 1790 RIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN-MTHTDAVNLLRAASKTVRLVIG 1847

Query: 222  RG-SLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT--- 277
            R   LP++                    P+    +  I L  +   LGF + GG  +   
Sbjct: 1848 RVLELPRI--------------------PMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ 1887

Query: 278  GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322
             V +  I P  VA   G L   D I  +      GM+ E+V + L
Sbjct: 1888 VVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL 1932



 Score = 48.9 bits (115), Expect = 5e-05
 Identities = 37/134 (27%), Positives = 68/134 (50%), Gaps = 13/134 (9%)

Query: 372  ESETFDVELTKNVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
            E E   V L K+ + GLG  I G     +L+  GIF+ S+      + DG ++ GD++I+
Sbjct: 1069 EREITLVNLKKDAKYGLGFQIIGGEKMGRLD-LGIFISSVAPGGPADLDGCLKPGDRLIS 1127

Query: 431  VDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASII 490
            V+  +L+G ++  A+E+L++  + V L +      Q  E +S+   T      PV+ +  
Sbjct: 1128 VNSVSLEGVSHHAAIEILQNAPEDVTLVI-----SQPKEKISKVPST------PVHLTNE 1176

Query: 491  KENYEKDEDFLSST 504
             +NY K   ++  +
Sbjct: 1177 MKNYMKKSSYMQDS 1190



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 47/168 (27%), Positives = 72/168 (42%), Gaps = 28/168 (16%)

Query: 471  MSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDA 530
            MSR D    A ++ +N S              S  + N  P E   +   S+ IE+   A
Sbjct: 1007 MSRSDAESLAGVTKLNNS-------------KSVASLNRSP-ERRKHESDSSSIEDPGQA 1052

Query: 531  QKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH---------FIRSV 581
               +  L  +W  +     EI + ++ K ++  GLG  +   +G           FI SV
Sbjct: 1053 YVLDV-LHKRWSIVSSPEREITLVNLKKDAKY-GLGFQI---IGGEKMGRLDLGIFISSV 1107

Query: 582  LPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
             P GP    G L  GD L+ VN ++L G +H   + IL+  P +VT+V
Sbjct: 1108 APGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV 1155



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 31/82 (37%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1959 ITLERGPDG-LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
            ITL +   G LGF++  G    +  +  YV  V    A S DGRLK GD++I VN   + 
Sbjct: 1770 ITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVT 1824

Query: 2018 GVTHEEAVAILKRTKGTVTLMV 2039
             +TH +AV +L+    TV L++
Sbjct: 1825 NMTHTDAVNLLRAASKTVRLVI 1846



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 31/138 (22%), Positives = 57/138 (41%), Gaps = 18/138 (13%)

Query: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNA----- 1414
            LG SL G  D     V+I  I+P   A  +G LQ+ D +  +NG    G + +       
Sbjct: 1874 LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALD 1933

Query: 1415 ----SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSD 1470
                S ++K   + + ++    + AV+      GN    + S S        +P +T +D
Sbjct: 1934 MSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS--------QPALTPND 1985

Query: 1471 AAVDLSSFKNVQHLELPK 1488
            +   ++  + +  +  PK
Sbjct: 1986 SFSTVAG-EEINEISYPK 2002


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score =  139 bits (349), Expect = 4e-32
 Identities = 143/462 (30%), Positives = 203/462 (43%), Gaps = 64/462 (13%)

Query: 1607 SSTPAIFASDPA-TCPIIPGCETTIE-----ISKGRTGLGLSIVGGSDTL-LG---AIII 1656
            S  P I  +D   T P + G E   E     + +G +GLG SI GG+D   +G    I I
Sbjct: 175  SPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFI 234

Query: 1657 HEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1716
             ++   GAA +DGRL   D IL VN +D+ + +H +A+  L++    VRL + R   P  
Sbjct: 235  TKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR-RRPIL 293

Query: 1717 EEEVCDTLTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGD 1770
            E  V     I+L K P KGLG SI G         D  ++V+ I+ GG A  DGRL  GD
Sbjct: 294  ETVV----EIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGD 348

Query: 1771 QILMVNGEDVRNAT-QEAVAAL--------LKVSEGSLSSFTFPLSGSSTSESLESSSKK 1821
            ++LMVN   +   T +EAVA L        LKV + +    T P      + S  S   +
Sbjct: 349  RLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSY-SPPME 407

Query: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVG 1881
            N L S   G    +    P       I+ G  SP+           P  +       R  
Sbjct: 408  NHLLSGNNGTLEYKTSLPP-------ISPGRYSPI-----------PKHMLVDDDYTRPP 449

Query: 1882 DRIVTICGTSTE---GMTHTQAVNLLKNASGSIEMQVVAGGDV--SVVTGHQQEPASSSL 1936
            + + +      +      H   V   K+   S        G +  S +T H Q   ++  
Sbjct: 450  EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 509

Query: 1937 SFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAA 1996
                L  +   +   G P  + + L +G  GLGF+IVGG         I+V  + A G A
Sbjct: 510  PSMTLQRAVSLE---GEP--RKVVLHKGSTGLGFNIVGGEDGEG----IFVSFILAGGPA 560

Query: 1997 SEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
               G L+RGDQI++VNG  L G +HE+A A LK    TVT++
Sbjct: 561  DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602



 Score =  119 bits (297), Expect = 4e-26
 Identities = 91/274 (33%), Positives = 135/274 (49%), Gaps = 42/274 (15%)

Query: 1775 VNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSST-----SESLESSSKKNALASEIQ 1829
            V G ++ + +++ ++ +  V    L S   PL  S       +++L++    N    E +
Sbjct: 141  VRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYE 200

Query: 1830 GLRTVEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTI 1887
                + +++G    LG SIAGG  +P +GD P IFI  + P G AA+  +LRV D I+ +
Sbjct: 201  -FEEITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 258

Query: 1888 CGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIF 1947
                   ++H++AV  LK A   + + V            ++ P   ++           
Sbjct: 259  NEVDVSEVSHSKAVEALKEAGSIVRLYV-----------RRRRPILETVV---------- 297

Query: 1948 QDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRG 2005
                       I L +GP GLGFSI GG G+ H  GD  IYV  +   GAA +DGRL+ G
Sbjct: 298  ----------EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 347

Query: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            D+++ VN  SLE VTHEEAVAILK T   V L V
Sbjct: 348  DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381



 Score =  110 bits (275), Expect = 1e-23
 Identities = 109/462 (23%), Positives = 195/462 (42%), Gaps = 98/462 (21%)

Query: 230 SPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT-------GVIVK 282
           +PI+  + +  +    +   + ++  E I L    SGLGF I GG          G+ + 
Sbjct: 177 APIIVNTDTLDTIPYVNGTEIEYE-FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 235

Query: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT 342
            I+PGG A + GRL   D IL++ + D++ +S  +  + L++ G+ V+L + R       
Sbjct: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR------- 288

Query: 343 APTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE- 401
                           P L               +++L K  +GLG +IAG +G++ +  
Sbjct: 289 --------------RRPILET-----------VVEIKLFKGPKGLGFSIAGGVGNQHIPG 323

Query: 402 PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
            + I+V  I    A + DGR+Q+GD+++ V+  +L+  T+++AV +L++T + V L + +
Sbjct: 324 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 383

Query: 462 ------------------RGMKQEAELMSREDVTKD--ADLSPVNAS---------IIKE 492
                                  E  L+S  + T +    L P++           ++ +
Sbjct: 384 PTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD 443

Query: 493 NYEKDEDFLSSTRN---------TNILPTEEEGYPLLSA-----------EIEEIEDAQK 532
           +Y +  + + ST N          +  P E +   LLSA           + E    +Q 
Sbjct: 444 DYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQH 503

Query: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVLPEGPV 587
             A           ++ E     V     ++GLG ++   VG       F+  +L  GP 
Sbjct: 504 STATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI---VGGEDGEGIFVSFILAGGPA 560

Query: 588 GHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
             SG+L  GD++L VNGI L G +H+     LK     VT++
Sbjct: 561 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 112/475 (23%), Positives = 182/475 (38%), Gaps = 131/475 (27%)

Query: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++   D        G+ +  II GGA + DGR+ + DCIL +NE   
Sbjct: 204  ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
              V++++A   L+                            ++G ++ L     Y  R  
Sbjct: 264  SEVSHSKAVEALK----------------------------EAGSIVRL-----YVRRRR 290

Query: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
            P L    E                     ++L++ P K LG SI GG  +G++   G+  
Sbjct: 291  PILETVVE---------------------IKLFKGP-KGLGFSIAGG--VGNQHIPGD-- 324

Query: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR--------KAGNP 1234
              I++  +++   A K+G L+ GDR++ V+   L + +HE+AV  ++        K G P
Sbjct: 325  NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 384

Query: 1235 VVFMVQSIINRP----------------------------------RKSPLPSLLHNLYP 1260
                +      P                                  R SP+P   H L  
Sbjct: 385  TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK--HMLVD 442

Query: 1261 KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAF-------AEMGSDHT 1313
                    P   ++    DK  S     P +     +   P S +       +EM S   
Sbjct: 443  DDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQ 502

Query: 1314 QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373
             S+A++                   +R  +L GE   + L KG +GLG ++ G +D    
Sbjct: 503  HSTATRQPSMT-------------LQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE-- 547

Query: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKII 1428
             +F+  I   G A   G LQ  D++L +NG  L G SH+ A++ +K A   V II
Sbjct: 548  GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 602



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 127/459 (27%), Positives = 177/459 (38%), Gaps = 123/459 (26%)

Query: 654  TEKPHV--DLGEFI-----GSSETEDPVLAMTDAGQSTEEV--------QAPLAMWEAG- 697
            T+ PH+  D G FI     G +  ED  L + D      EV        +A  A+ EAG 
Sbjct: 221  TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS 280

Query: 698  ---------------IQHIELEKGSKGLGFSILD-YQDPIDPASTVIIIRSLVPGGIAEK 741
                           +  I+L KG KGLGFSI     +   P    I +  ++ GG A+K
Sbjct: 281  IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 340

Query: 742  DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKED 801
            DGRL  GDRL+ VN+ +LE  + EEAV  LK   S  V + V KP  +     Y++    
Sbjct: 341  DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTI-----YMT---- 390

Query: 802  SFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILS 861
                                                      PY P +  I  + +  + 
Sbjct: 391  -----------------------------------------DPYGPPD--ITHSYSPPME 407

Query: 862  LHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVD 920
             H  S  +G L Y +SLP   P         P+   HM +++ YT     R  E   S  
Sbjct: 408  NHLLSGNNGTLEYKTSLPPISP-----GRYSPI-PKHMLVDDDYT-----RPPEPVYS-- 454

Query: 921  ISMGPASGFTINDYTPANAIEQQY---ECENTIVWTESHLPSEVISSAELPSVLPDSAGK 977
                     T+N      A  + Y   EC+      +S L S   S   L  +LPDS   
Sbjct: 455  ---------TVNKLCDKPASPRHYSPVECD------KSFLLSAPYSHYHL-GLLPDSEMT 498

Query: 978  GSEYLLEQSSLACNAECVMLQN-VSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSI 1036
                   Q S A     + LQ  VS E   R + + KG++ LG  +   +DG G+ V  I
Sbjct: 499  SHS----QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 554

Query: 1037 IHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
            + GG     G +  GD ILS+N       ++ QA A L+
Sbjct: 555  LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 90/311 (28%), Positives = 131/311 (42%), Gaps = 84/311 (27%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DGR+ +GD +L +N 
Sbjct: 299  IKLFKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355

Query: 1060 ESTISVTNAQARAMLRRHSLI------------------GPDIKITYVPA--EHLE---- 1095
             S   VT+ +A A+L+  S +                   PDI  +Y P    HL     
Sbjct: 356  YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 415

Query: 1096 ---EFKISL-----GQQSGRVMALDIFSSYTGR------------DIPELPEREEG-EGE 1134
               E+K SL     G+ S     + +   YT              D P  P      E +
Sbjct: 416  GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECD 475

Query: 1135 ESELQNTAYSNWN--------------------QP-----RRVELWREPSKSLGISIVGG 1169
            +S L +  YS+++                    QP     R V L  EP K   +   G 
Sbjct: 476  KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV--VLHKGS 533

Query: 1170 RGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
             G+G  +  GE   GIF+  +L   PA  +G L+ GD+I+ V+G+DLR ASHEQA  A++
Sbjct: 534  TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 593

Query: 1230 KAGNPVVFMVQ 1240
             AG  V  + Q
Sbjct: 594  GAGQTVTIIAQ 604



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 76/307 (24%), Positives = 125/307 (40%), Gaps = 60/307 (19%)

Query: 69  TSNIEYAHVPHLSPAVIPTLQN-ESFLLSPNNGNLEALTGP---------GIPHINGKPA 118
           T  +    + H+S   +  ++N   ++L  +   L+A   P          IP++NG   
Sbjct: 138 THEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEI 197

Query: 119 CDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVA 176
             EF+++               L+  + GLGFS+ G         + GIF+ +I  G  A
Sbjct: 198 EYEFEEIT--------------LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAA 243

Query: 177 HRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRS 236
             DGRL+  D IL +N   + + ++H +A+  L++A   V+L + R            R 
Sbjct: 244 AEDGRLRVNDCILRVNEVDVSE-VSHSKAVEALKEAGSIVRLYVRR------------RR 290

Query: 237 PSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGV 289
           P   + +              I+L     GLGF I GG           + V  I+ GG 
Sbjct: 291 PILETVVE-------------IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGA 337

Query: 290 ADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTA-LG 348
           A + GRL  GD +L + +  L  ++ E+   +L+     V L + +      T P     
Sbjct: 338 AQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPD 397

Query: 349 ITLSSSP 355
           IT S SP
Sbjct: 398 ITHSYSP 404



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 40/218 (18%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +     +FI  I P GAA +DGRL++ D +L +N
Sbjct: 200  EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 259

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   SH  A   +K A S V++   R +  +                          
Sbjct: 260  EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-------------------------- 293

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
                   +  V++  FK  + L      GG+G      D  + + +  + + G A  DGR
Sbjct: 294  -------ETVVEIKLFKGPKGLGF-SIAGGVGNQHIPGD--NSIYVTKIIDGGAAQKDGR 343

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
            L+VGD++L V++  +     E+ +++LK     V L +
Sbjct: 344  LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 44/118 (37%), Positives = 63/118 (53%), Gaps = 4/118 (3%)

Query: 673 PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
           P++  TD   +   V      +E   + I LE+G+ GLGFSI    D P       I I 
Sbjct: 178 PIIVNTDTLDTIPYVNGTEIEYE--FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 235

Query: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPL 789
            ++PGG A +DGRL   D ++ VN+V++   S  +AVEALK A S  VR+ V +  P+
Sbjct: 236 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS-IVRLYVRRRRPI 292



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 69/260 (26%), Positives = 98/260 (37%), Gaps = 66/260 (25%)

Query: 544 IMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLFS 595
           + G   E     ++    NSGLG S+   T   H       FI  ++P G     G+L  
Sbjct: 192 VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 251

Query: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
            D +L VN + +   +H   V  LKE    V +   RR   P  ++      + +I+L +
Sbjct: 252 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRR--PILET------VVEIKLFK 303

Query: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
            P   LG  I                               G QHI              
Sbjct: 304 GPK-GLGFSIAGG---------------------------VGNQHI-------------- 321

Query: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAP 775
                  P    I +  ++ GG A+KDGRL  GDRL+ VN+ +LE  + EEAV  LK   
Sbjct: 322 -------PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT- 373

Query: 776 SGTVRIGVAKPLPLSPEEGY 795
           S  V + V KP  +   + Y
Sbjct: 374 SEVVYLKVGKPTTIYMTDPY 393



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 7/129 (5%)

Query: 658 HVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
           H  LG  +  SE        T   Q +  +Q  +++ E   + + L KGS GLGF+I+  
Sbjct: 486 HYHLG-LLPDSEMTSHSQHSTATRQPSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVGG 543

Query: 718 QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG 777
           +D        I +  ++ GG A+  G L  GD+++ VN ++L  +S E+A  ALKGA   
Sbjct: 544 ED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 598

Query: 778 TVRIGVAKP 786
              I   +P
Sbjct: 599 VTIIAQYQP 607



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 33/80 (41%), Positives = 46/80 (57%), Gaps = 5/80 (6%)

Query: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199
           +L   S GLGF++VG      GE GIFV  I  G  A   G L+  DQIL++NG  L + 
Sbjct: 528 VLHKGSTGLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RG 582

Query: 200 ITHQQAISILQKAKDTVQLV 219
            +H+QA + L+ A  TV ++
Sbjct: 583 ASHEQAAAALKGAGQTVTII 602



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 6/95 (6%)

Query: 1482 QHLELPKDQGGLGIAISEEDTLS------GVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
            + + L +   GLG +I+            G+ I  +   G AA DGRL+V D IL V++ 
Sbjct: 202  EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 261

Query: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAV 1570
             V      K +  LK A   V+L +    P  + V
Sbjct: 262  DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETV 296



 Score = 38.1 bits (87), Expect = 0.089
 Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 12/126 (9%)

Query: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
           V  +  F    GLG S+   VG+         ++  ++  G     G+L  GD LL VN 
Sbjct: 296 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 355

Query: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEF 664
            +L    H++ V ILK      + V   +   PTT    D     DI  +  P ++    
Sbjct: 356 YSLEEVTHEEAVAILK----NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 411

Query: 665 IGSSET 670
            G++ T
Sbjct: 412 SGNNGT 417



 Score = 35.0 bits (79), Expect = 0.75
 Identities = 25/81 (30%), Positives = 37/81 (45%)

Query: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
            L K   GLG  I   +   G+ +  +   G A   G L+ GDQIL+V+   + G   E+ 
Sbjct: 529  LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 588

Query: 1546 ISLLKTAKMTVKLTIHAENPD 1566
             + LK A  TV +    +  D
Sbjct: 589  AAALKGAGQTVTIIAQYQPED 609


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score =  139 bits (349), Expect = 4e-32
 Identities = 143/462 (30%), Positives = 203/462 (43%), Gaps = 64/462 (13%)

Query: 1607 SSTPAIFASDPA-TCPIIPGCETTIE-----ISKGRTGLGLSIVGGSDTL-LG---AIII 1656
            S  P I  +D   T P + G E   E     + +G +GLG SI GG+D   +G    I I
Sbjct: 70   SPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFI 129

Query: 1657 HEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1716
             ++   GAA +DGRL   D IL VN +D+ + +H +A+  L++    VRL + R   P  
Sbjct: 130  TKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR-RRPIL 188

Query: 1717 EEEVCDTLTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGD 1770
            E  V     I+L K P KGLG SI G         D  ++V+ I+ GG A  DGRL  GD
Sbjct: 189  ETVV----EIKLFKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGD 243

Query: 1771 QILMVNGEDVRNAT-QEAVAAL--------LKVSEGSLSSFTFPLSGSSTSESLESSSKK 1821
            ++LMVN   +   T +EAVA L        LKV + +    T P      + S  S   +
Sbjct: 244  RLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSY-SPPME 302

Query: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVG 1881
            N L S   G    +    P       I+ G  SP+           P  +       R  
Sbjct: 303  NHLLSGNNGTLEYKTSLPP-------ISPGRYSPI-----------PKHMLVDDDYTRPP 344

Query: 1882 DRIVTICGTSTE---GMTHTQAVNLLKNASGSIEMQVVAGGDV--SVVTGHQQEPASSSL 1936
            + + +      +      H   V   K+   S        G +  S +T H Q   ++  
Sbjct: 345  EPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQ 404

Query: 1937 SFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAA 1996
                L  +   +   G P  + + L +G  GLGF+IVGG         I+V  + A G A
Sbjct: 405  PSMTLQRAVSLE---GEP--RKVVLHKGSTGLGFNIVGGEDGEG----IFVSFILAGGPA 455

Query: 1997 SEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
               G L+RGDQI++VNG  L G +HE+A A LK    TVT++
Sbjct: 456  DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497



 Score =  119 bits (297), Expect = 4e-26
 Identities = 91/274 (33%), Positives = 135/274 (49%), Gaps = 42/274 (15%)

Query: 1775 VNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSST-----SESLESSSKKNALASEIQ 1829
            V G ++ + +++ ++ +  V    L S   PL  S       +++L++    N    E +
Sbjct: 36   VRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYE 95

Query: 1830 GLRTVEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTI 1887
                + +++G    LG SIAGG  +P +GD P IFI  + P G AA+  +LRV D I+ +
Sbjct: 96   -FEEITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRV 153

Query: 1888 CGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIF 1947
                   ++H++AV  LK A   + + V            ++ P   ++           
Sbjct: 154  NEVDVSEVSHSKAVEALKEAGSIVRLYV-----------RRRRPILETVV---------- 192

Query: 1948 QDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRG 2005
                       I L +GP GLGFSI GG G+ H  GD  IYV  +   GAA +DGRL+ G
Sbjct: 193  ----------EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVG 242

Query: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            D+++ VN  SLE VTHEEAVAILK T   V L V
Sbjct: 243  DRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276



 Score =  110 bits (275), Expect = 1e-23
 Identities = 109/462 (23%), Positives = 195/462 (42%), Gaps = 98/462 (21%)

Query: 230 SPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT-------GVIVK 282
           +PI+  + +  +    +   + ++  E I L    SGLGF I GG          G+ + 
Sbjct: 72  APIIVNTDTLDTIPYVNGTEIEYE-FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 130

Query: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERT 342
            I+PGG A + GRL   D IL++ + D++ +S  +  + L++ G+ V+L + R       
Sbjct: 131 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR------- 183

Query: 343 APTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE- 401
                           P L               +++L K  +GLG +IAG +G++ +  
Sbjct: 184 --------------RRPILET-----------VVEIKLFKGPKGLGFSIAGGVGNQHIPG 218

Query: 402 PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
            + I+V  I    A + DGR+Q+GD+++ V+  +L+  T+++AV +L++T + V L + +
Sbjct: 219 DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGK 278

Query: 462 ------------------RGMKQEAELMSREDVTKD--ADLSPVNAS---------IIKE 492
                                  E  L+S  + T +    L P++           ++ +
Sbjct: 279 PTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDD 338

Query: 493 NYEKDEDFLSSTRN---------TNILPTEEEGYPLLSA-----------EIEEIEDAQK 532
           +Y +  + + ST N          +  P E +   LLSA           + E    +Q 
Sbjct: 339 DYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQH 398

Query: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVLPEGPV 587
             A           ++ E     V     ++GLG ++   VG       F+  +L  GP 
Sbjct: 399 STATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNI---VGGEDGEGIFVSFILAGGPA 455

Query: 588 GHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
             SG+L  GD++L VNGI L G +H+     LK     VT++
Sbjct: 456 DLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 112/475 (23%), Positives = 182/475 (38%), Gaps = 131/475 (27%)

Query: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++   D        G+ +  II GGA + DGR+ + DCIL +NE   
Sbjct: 99   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
              V++++A   L+                            ++G ++ L     Y  R  
Sbjct: 159  SEVSHSKAVEALK----------------------------EAGSIVRL-----YVRRRR 185

Query: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
            P L    E                     ++L++ P K LG SI GG  +G++   G+  
Sbjct: 186  PILETVVE---------------------IKLFKGP-KGLGFSIAGG--VGNQHIPGD-- 219

Query: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR--------KAGNP 1234
              I++  +++   A K+G L+ GDR++ V+   L + +HE+AV  ++        K G P
Sbjct: 220  NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 279

Query: 1235 VVFMVQSIINRP----------------------------------RKSPLPSLLHNLYP 1260
                +      P                                  R SP+P   H L  
Sbjct: 280  TTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPK--HMLVD 337

Query: 1261 KYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAF-------AEMGSDHT 1313
                    P   ++    DK  S     P +     +   P S +       +EM S   
Sbjct: 338  DDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQ 397

Query: 1314 QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373
             S+A++                   +R  +L GE   + L KG +GLG ++ G +D    
Sbjct: 398  HSTATRQPSMT-------------LQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGE-- 442

Query: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKII 1428
             +F+  I   G A   G LQ  D++L +NG  L G SH+ A++ +K A   V II
Sbjct: 443  GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 497



 Score = 85.9 bits (211), Expect = 4e-16
 Identities = 127/459 (27%), Positives = 177/459 (38%), Gaps = 123/459 (26%)

Query: 654  TEKPHV--DLGEFI-----GSSETEDPVLAMTDAGQSTEEV--------QAPLAMWEAG- 697
            T+ PH+  D G FI     G +  ED  L + D      EV        +A  A+ EAG 
Sbjct: 116  TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS 175

Query: 698  ---------------IQHIELEKGSKGLGFSILD-YQDPIDPASTVIIIRSLVPGGIAEK 741
                           +  I+L KG KGLGFSI     +   P    I +  ++ GG A+K
Sbjct: 176  IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 235

Query: 742  DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKED 801
            DGRL  GDRL+ VN+ +LE  + EEAV  LK   S  V + V KP  +     Y++    
Sbjct: 236  DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTI-----YMT---- 285

Query: 802  SFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILS 861
                                                      PY P +  I  + +  + 
Sbjct: 286  -----------------------------------------DPYGPPD--ITHSYSPPME 302

Query: 862  LHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVD 920
             H  S  +G L Y +SLP   P         P+   HM +++ YT     R  E   S  
Sbjct: 303  NHLLSGNNGTLEYKTSLPPISP-----GRYSPI-PKHMLVDDDYT-----RPPEPVYS-- 349

Query: 921  ISMGPASGFTINDYTPANAIEQQY---ECENTIVWTESHLPSEVISSAELPSVLPDSAGK 977
                     T+N      A  + Y   EC+      +S L S   S   L  +LPDS   
Sbjct: 350  ---------TVNKLCDKPASPRHYSPVECD------KSFLLSAPYSHYHL-GLLPDSEMT 393

Query: 978  GSEYLLEQSSLACNAECVMLQN-VSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSI 1036
                   Q S A     + LQ  VS E   R + + KG++ LG  +   +DG G+ V  I
Sbjct: 394  SHS----QHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFI 449

Query: 1037 IHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
            + GG     G +  GD ILS+N       ++ QA A L+
Sbjct: 450  LAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 90/311 (28%), Positives = 131/311 (42%), Gaps = 84/311 (27%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DGR+ +GD +L +N 
Sbjct: 194  IKLFKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 250

Query: 1060 ESTISVTNAQARAMLRRHSLI------------------GPDIKITYVPA--EHLE---- 1095
             S   VT+ +A A+L+  S +                   PDI  +Y P    HL     
Sbjct: 251  YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 310

Query: 1096 ---EFKISL-----GQQSGRVMALDIFSSYTGR------------DIPELPEREEG-EGE 1134
               E+K SL     G+ S     + +   YT              D P  P      E +
Sbjct: 311  GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECD 370

Query: 1135 ESELQNTAYSNWN--------------------QP-----RRVELWREPSKSLGISIVGG 1169
            +S L +  YS+++                    QP     R V L  EP K   +   G 
Sbjct: 371  KSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKV--VLHKGS 428

Query: 1170 RGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
             G+G  +  GE   GIF+  +L   PA  +G L+ GD+I+ V+G+DLR ASHEQA  A++
Sbjct: 429  TGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 488

Query: 1230 KAGNPVVFMVQ 1240
             AG  V  + Q
Sbjct: 489  GAGQTVTIIAQ 499



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 82/337 (24%), Positives = 138/337 (40%), Gaps = 66/337 (19%)

Query: 45  FSQILSLQTSVQQLKDQVNIATS------ATSNIEYAHVPHLSPAVIPTLQN-ESFLLSP 97
           F+   +L+T+V++ + Q   A         T  +    + H+S   +  ++N   ++L  
Sbjct: 3   FACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQS 62

Query: 98  NNGNLEALTGP---------GIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGL 148
           +   L+A   P          IP++NG     EF+++               L+  + GL
Sbjct: 63  HISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEIT--------------LERGNSGL 108

Query: 149 GFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
           GFS+ G         + GIF+ +I  G  A  DGRL+  D IL +N   + + ++H +A+
Sbjct: 109 GFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE-VSHSKAV 167

Query: 207 SILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSG 266
             L++A   V+L + R            R P   + +              I+L     G
Sbjct: 168 EALKEAGSIVRLYVRR------------RRPILETVVE-------------IKLFKGPKG 202

Query: 267 LGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVA 319
           LGF I GG           + V  I+ GG A + GRL  GD +L + +  L  ++ E+  
Sbjct: 203 LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAV 262

Query: 320 QVLRQCGNRVKLMIARGAIEERTAPTA-LGITLSSSP 355
            +L+     V L + +      T P     IT S SP
Sbjct: 263 AILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSP 299



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 59/218 (27%), Positives = 96/218 (44%), Gaps = 40/218 (18%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +     +FI  I P GAA +DGRL++ D +L +N
Sbjct: 95   EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 154

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   SH  A   +K A S V++   R +  +                          
Sbjct: 155  EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-------------------------- 188

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
                   +  V++  FK  + L      GG+G      D  + + +  + + G A  DGR
Sbjct: 189  -------ETVVEIKLFKGPKGLGF-SIAGGVGNQHIPGD--NSIYVTKIIDGGAAQKDGR 238

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
            L+VGD++L V++  +     E+ +++LK     V L +
Sbjct: 239  LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 44/118 (37%), Positives = 63/118 (53%), Gaps = 4/118 (3%)

Query: 673 PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
           P++  TD   +   V      +E   + I LE+G+ GLGFSI    D P       I I 
Sbjct: 73  PIIVNTDTLDTIPYVNGTEIEYE--FEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFIT 130

Query: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPL 789
            ++PGG A +DGRL   D ++ VN+V++   S  +AVEALK A S  VR+ V +  P+
Sbjct: 131 KIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS-IVRLYVRRRRPI 187



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 69/260 (26%), Positives = 98/260 (37%), Gaps = 66/260 (25%)

Query: 544 IMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLFS 595
           + G   E     ++    NSGLG S+   T   H       FI  ++P G     G+L  
Sbjct: 87  VNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRV 146

Query: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
            D +L VN + +   +H   V  LKE    V +   RR   P  ++      + +I+L +
Sbjct: 147 NDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRR--PILET------VVEIKLFK 198

Query: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
            P   LG  I                               G QHI              
Sbjct: 199 GPK-GLGFSIAGG---------------------------VGNQHI-------------- 216

Query: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAP 775
                  P    I +  ++ GG A+KDGRL  GDRL+ VN+ +LE  + EEAV  LK   
Sbjct: 217 -------PGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT- 268

Query: 776 SGTVRIGVAKPLPLSPEEGY 795
           S  V + V KP  +   + Y
Sbjct: 269 SEVVYLKVGKPTTIYMTDPY 288



 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 7/129 (5%)

Query: 658 HVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
           H  LG  +  SE        T   Q +  +Q  +++ E   + + L KGS GLGF+I+  
Sbjct: 381 HYHLG-LLPDSEMTSHSQHSTATRQPSMTLQRAVSL-EGEPRKVVLHKGSTGLGFNIVGG 438

Query: 718 QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG 777
           +D        I +  ++ GG A+  G L  GD+++ VN ++L  +S E+A  ALKGA   
Sbjct: 439 ED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQT 493

Query: 778 TVRIGVAKP 786
              I   +P
Sbjct: 494 VTIIAQYQP 502



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 33/80 (41%), Positives = 46/80 (57%), Gaps = 5/80 (6%)

Query: 140 LLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQT 199
           +L   S GLGF++VG      GE GIFV  I  G  A   G L+  DQIL++NG  L + 
Sbjct: 423 VLHKGSTGLGFNIVGGED---GE-GIFVSFILAGGPADLSGELQRGDQILSVNGIDL-RG 477

Query: 200 ITHQQAISILQKAKDTVQLV 219
            +H+QA + L+ A  TV ++
Sbjct: 478 ASHEQAAAALKGAGQTVTII 497



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 28/95 (29%), Positives = 42/95 (44%), Gaps = 6/95 (6%)

Query: 1482 QHLELPKDQGGLGIAISEEDTLS------GVIIKSLTEHGVAATDGRLKVGDQILAVDDE 1535
            + + L +   GLG +I+            G+ I  +   G AA DGRL+V D IL V++ 
Sbjct: 97   EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 156

Query: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAV 1570
             V      K +  LK A   V+L +    P  + V
Sbjct: 157  DVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETV 191



 Score = 38.1 bits (87), Expect = 0.089
 Identities = 33/126 (26%), Positives = 51/126 (40%), Gaps = 12/126 (9%)

Query: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
           V  +  F    GLG S+   VG+         ++  ++  G     G+L  GD LL VN 
Sbjct: 191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 250

Query: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEF 664
            +L    H++ V ILK      + V   +   PTT    D     DI  +  P ++    
Sbjct: 251 YSLEEVTHEEAVAILK----NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 306

Query: 665 IGSSET 670
            G++ T
Sbjct: 307 SGNNGT 312



 Score = 35.0 bits (79), Expect = 0.75
 Identities = 25/81 (30%), Positives = 37/81 (45%)

Query: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
            L K   GLG  I   +   G+ +  +   G A   G L+ GDQIL+V+   + G   E+ 
Sbjct: 424  LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQA 483

Query: 1546 ISLLKTAKMTVKLTIHAENPD 1566
             + LK A  TV +    +  D
Sbjct: 484  AAALKGAGQTVTIIAQYQPED 504


>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
          Length = 904

 Score =  138 bits (347), Expect = 6e-32
 Identities = 109/369 (29%), Positives = 173/369 (46%), Gaps = 63/369 (17%)

Query: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN------DTGVFVS 1752
            +TP  V  T    +A Y+ EE+    T+E   +   GLG SI G  +      D+ +F++
Sbjct: 208  ETPTYVNGT----DADYEYEEI----TLE---RGNSGLGFSIAGGTDNPHIGDDSSIFIT 256

Query: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS 1812
             I+ GG A  DGRL   D IL VN  DVR+ T       LK +   +  +          
Sbjct: 257  KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV--------- 307

Query: 1813 ESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL--GDVPIFIAMMHPTG 1870
                   ++  ++ +I  ++ ++  KG    LG SIAGGVG+    GD  I++  +   G
Sbjct: 308  ------KRRKPVSEKIMEIKLIKGPKG----LGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357

Query: 1871 VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSV------- 1923
             A +  KL++GD+++ +     E +TH +AV  LKN S  + ++V     + +       
Sbjct: 358  AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPP 417

Query: 1924 -VTGHQQEPASSSLS---FTGLT----------SSSIFQDDLGPPQCKSITLERGPDGLG 1969
             +T    +P  + +S   F G T          S ++  DD    + + + L RG  GLG
Sbjct: 418  DITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLG 477

Query: 1970 FSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK 2029
            F+IVGG         I++  + A G A   G L++GD+II+VN   L   +HE+A A LK
Sbjct: 478  FNIVGGEDGEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533

Query: 2030 RTKGTVTLM 2038
                 VT++
Sbjct: 534  NAGQAVTIV 542



 Score =  116 bits (291), Expect = 2e-25
 Identities = 101/326 (30%), Positives = 154/326 (47%), Gaps = 55/326 (16%)

Query: 1630 IEISKGRTGLGLSIVGGSDTLL----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
            I + +G +GLG SI GG+D        +I I ++   GAA +DGRL   D IL VN +D+
Sbjct: 225  ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284

Query: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743
            R  TH +A+  L++    VRL + R   P  E+     + I+L K P KGLG SI G   
Sbjct: 285  RDVTHSKAVEALKEAGSIVRLYVKR-RKPVSEK----IMEIKLIKGP-KGLGFSIAGGVG 338

Query: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEAVAALLKVSEGS 1798
                  D  ++V+ I++GG A  DG+L  GD++L VN   +   T +EAV AL   S+  
Sbjct: 339  NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398

Query: 1799 LSSFTFPLS------------GSSTSESLE--------------SSSKKNALASEIQG-- 1830
                  P S             +S+S+ ++              S ++ + ++  + G  
Sbjct: 399  YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDD 458

Query: 1831 -----LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIV 1885
                  R V + +G T  LG +I GG         IFI+ +   G A  + +LR GDRI+
Sbjct: 459  EITREPRKVVLHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDRII 513

Query: 1886 TICGTSTEGMTHTQAVNLLKNASGSI 1911
            ++        +H QA   LKNA  ++
Sbjct: 514  SVNSVDLRAASHEQAAAALKNAGQAV 539



 Score =  115 bits (287), Expect = 6e-25
 Identities = 138/637 (21%), Positives = 252/637 (39%), Gaps = 114/637 (17%)

Query: 6   DKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQT--SVQQLKDQVN 63
           D  RALH  E  ++KL +  D      +  + ++ QS LF  ++ +Q    V  L +   
Sbjct: 7   DTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66

Query: 64  IATSATSN-IEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEF 122
           I  S  S  I+  +   +S     T+ +E+   S +                  P+ +++
Sbjct: 67  IDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLS------------------PSVEKY 108

Query: 123 DQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRD-GR 181
               ++     H+      +  +  +G  +V +  +N  E+     E   G V+H     
Sbjct: 109 RYQDEDTPPQEHISP----QITNEVIGPELVHVSEKNLSEI-----ENVHGFVSHSHISP 159

Query: 182 LKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAAS 241
           +K T+ +L                + ++       +  +   ++PQ   P V  +  +  
Sbjct: 160 IKPTEAVLP-----------SPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLE 208

Query: 242 TISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKA-------TGVIVKTILPGGVADQHG 294
           T +  +        E I L    SGLGF I GG         + + +  I+ GG A Q G
Sbjct: 209 TPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG 268

Query: 295 RLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSS 354
           RL   D IL++ + D+  ++  +  + L++ G+ V+L + R                   
Sbjct: 269 RLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR------------------- 309

Query: 355 PTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKS 413
                        +K    +  +++L K  +GLG +IAG +G++ +   + I+V  I + 
Sbjct: 310 -------------RKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 356

Query: 414 SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSR 473
            A   DG++QIGD+++AV+   L+  T+++AV  L++T   V L + +       +  + 
Sbjct: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416

Query: 474 EDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGY-PLLSAEIEEIEDAQK 532
            D+T  +   PV      +N+     FL  T      P     Y P+  A + + E  ++
Sbjct: 417 PDITNSSS-QPV------DNHVSPSSFLGQT------PASPARYSPVSKAVLGDDEITRE 463

Query: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGK 592
               +L +    +G N               G GI         FI  +L  GP   SG+
Sbjct: 464 PRKVVLHRGSTGLGFNI---------VGGEDGEGI---------FISFILAGGPADLSGE 505

Query: 593 LFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
           L  GD ++ VN + L   +H+     LK     VT+V
Sbjct: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIV 542



 Score =  112 bits (281), Expect = 3e-24
 Identities = 82/232 (35%), Positives = 117/232 (50%), Gaps = 37/232 (15%)

Query: 1812 SESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGD-VPIFIAMMHPT 1869
            ++SLE+ +  N   ++ +    + +++G    LG SIAGG  +P +GD   IFI  +   
Sbjct: 204  TDSLETPTYVNGTDADYE-YEEITLERG-NSGLGFSIAGGTDNPHIGDDSSIFITKIITG 261

Query: 1870 GVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQ 1929
            G AAQ  +LRV D I+ +       +TH++AV  LK A   + + V            ++
Sbjct: 262  GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV-----------KRR 310

Query: 1930 EPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYV 1987
            +P S  +                      I L +GP GLGFSI GG G+ H  GD  IYV
Sbjct: 311  KPVSEKIM--------------------EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350

Query: 1988 KTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
              +   GAA +DG+L+ GD+++AVN   LE VTHEEAV  LK T   V L V
Sbjct: 351  TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402



 Score =  112 bits (280), Expect = 4e-24
 Identities = 108/382 (28%), Positives = 166/382 (43%), Gaps = 62/382 (16%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +    S+FI  I   GAA +DGRL++ D +L +N
Sbjct: 221  EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   +H  A   +K A S V++   R K                       +  K  
Sbjct: 281  EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP----------------------VSEKIM 318

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
            E  +      +  S    V +  +P D              + + +  + E G A  DG+
Sbjct: 319  EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGK 364

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
            L++GD++LAV++  +     E+ ++ LK     V L +    P S  +    G A  +  
Sbjct: 365  LQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV--AKPTSMYMND--GYAPPDIT 420

Query: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIE-----ISKGRT 1637
            NSS     P      P S    + +S PA ++  P +  ++   E T E     + +G T
Sbjct: 421  NSSSQ---PVDNHVSPSSFLGQTPAS-PARYS--PVSKAVLGDDEITREPRKVVLHRGST 474

Query: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697
            GLG +IVGG D     I I  +   G A   G L  GD+I+ VN +DLR A+H++A   L
Sbjct: 475  GLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532

Query: 1698 RQTPQRVRLTLYRDEAPYKEEE 1719
            +   Q V +      A Y+ EE
Sbjct: 533  KNAGQAVTIV-----AQYRPEE 549



 Score =  102 bits (253), Expect = 5e-21
 Identities = 106/420 (25%), Positives = 181/420 (43%), Gaps = 88/420 (20%)

Query: 77  VPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVE 136
           VP  +  ++PT+   +    P   N ++L  P   ++NG  A  E++++           
Sbjct: 181 VPAENTVILPTIPQAN--PPPVLVNTDSLETP--TYVNGTDADYEYEEIT---------- 226

Query: 137 VFELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
               L+  + GLGFS+ G         +  IF+ +I  G  A +DGRL+  D IL +N  
Sbjct: 227 ----LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282

Query: 195 ALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
            + + +TH +A+  L++A   V+L + R                          PV  + 
Sbjct: 283 DV-RDVTHSKAVEALKEAGSIVRLYVKR------------------------RKPVSEKI 317

Query: 255 METIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGD 307
           ME I+L+    GLGF I GG           + V  I+ GG A + G+L  GD +L + +
Sbjct: 318 ME-IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNN 376

Query: 308 TDLAGMSSEQVAQVLRQCGNRVKLMIARGA--------------------IEERTAPTA- 346
             L  ++ E+    L+   + V L +A+                      ++   +P++ 
Sbjct: 377 VCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF 436

Query: 347 LGITLSS----SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEP 402
           LG T +S    SP S   L  D  T++  +     V L +   GLG  I G  G+   + 
Sbjct: 437 LGQTPASPARYSPVSKAVLGDDEITREPRK-----VVLHRGSTGLGFNIVG--GE---DG 486

Query: 403 SGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
            GIF+  I      +  G ++ GD+II+V+  +L+  +++QA   L++ GQ V +    R
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 97/426 (22%), Positives = 171/426 (40%), Gaps = 114/426 (26%)

Query: 1009 INIAKGNSSLGMTVSANKDG------LGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++   D         + +  II GGA ++DGR+ + DCIL +NE   
Sbjct: 225  ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
              VT+++A   L+                            ++G ++ L     Y  R  
Sbjct: 285  RDVTHSKAVEALK----------------------------EAGSIVRL-----YVKRRK 311

Query: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
            P   +  E                     ++L + P K LG SI GG  +G++   G+  
Sbjct: 312  PVSEKIME---------------------IKLIKGP-KGLGFSIAGG--VGNQHIPGD-- 345

Query: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
              I++  ++E   A K+G L+ GD+++ V+ + L + +HE+AV A++   + V   V   
Sbjct: 346  NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK- 404

Query: 1243 INRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPP 1302
                   P    +++ Y   + +           N+   P  +   P         P  P
Sbjct: 405  -------PTSMYMNDGYAPPDIT-----------NSSSQPVDNHVSPSS--FLGQTPASP 444

Query: 1303 SAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGL 1362
            + +            S +S+ V  +DE              +T E   + L +G +GLG 
Sbjct: 445  ARY------------SPVSKAVLGDDE--------------ITREPRKVVLHRGSTGLGF 478

Query: 1363 SLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAP 1422
            ++ G +D     +FI  I   G A   G L+  D ++ +N   L   SH+ A++ +K A 
Sbjct: 479  NIVGGEDGE--GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

Query: 1423 SKVKII 1428
              V I+
Sbjct: 537  QAVTIV 542



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 85/286 (29%), Positives = 138/286 (48%), Gaps = 35/286 (12%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DG++ IGD +L++N 
Sbjct: 320  IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNN 376

Query: 1060 ESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF---SS 1116
                 VT+ +A   L+  S     +K+    + ++ +        +     +D     SS
Sbjct: 377  VCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435

Query: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176
            + G+  P  P R     + + L +   +   +PR+V L R  S  LG +IVGG       
Sbjct: 436  FLGQT-PASPARYSPVSK-AVLGDDEITR--EPRKVVLHRG-STGLGFNIVGGE------ 484

Query: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVV 1236
             +GE   GIFI  +L   PA  +G L+ GDRI+ V+ +DLR ASHEQA  A++ AG  V 
Sbjct: 485  -DGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540

Query: 1237 FMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
             + Q    RP + S   + +H+L  +   SS +  + SL+ +  ++
Sbjct: 541  IVAQ---YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 101/406 (24%), Positives = 168/406 (41%), Gaps = 74/406 (18%)

Query: 673  PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
            PVL  TD+ ++   V    A +E   + I LE+G+ GLGFSI    D P     + I I 
Sbjct: 199  PVLVNTDSLETPTYVNGTDADYE--YEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT 256

Query: 732  SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
             ++ GG A +DGRL   D ++ VN+V++ + +  +AVEALK A S  VR+ V +  P+S 
Sbjct: 257  KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGS-IVRLYVKRRKPVSE 315

Query: 792  EEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDS 851
            +                      + +  L +    L G + A  V      + + P ++S
Sbjct: 316  K----------------------IMEIKLIKGPKGL-GFSIAGGVG-----NQHIPGDNS 347

Query: 852  IYSTQASILSLHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQ 910
            IY T+   +   G++  DG L  G  L +      + N C         LEE+  +  + 
Sbjct: 348  IYVTK---IIEGGAAHKDGKLQIGDKLLA------VNNVC---------LEEVTHEEAVT 389

Query: 911  RQDENTPSVDISMGPASGFTIND-YTPANAIEQQYECENTIVWTESHLPSEVISSAELPS 969
                 +  V + +   +   +ND Y P +      +  +  V   S L     S A    
Sbjct: 390  ALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSP 449

Query: 970  VLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGL 1029
            V        S+ +L    +      V+L               +G++ LG  +   +DG 
Sbjct: 450  V--------SKAVLGDDEITREPRKVVLH--------------RGSTGLGFNIVGGEDGE 487

Query: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
            G+ +  I+ GG     G +  GD I+S+N     + ++ QA A L+
Sbjct: 488  GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 64/235 (27%), Positives = 100/235 (42%), Gaps = 27/235 (11%)

Query: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
           GLG S+   VG+         ++  ++  G     GKL  GD+LL VN + L    H++ 
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVL 675
           V  LK     V +    +   PT+    D     DI  +    VD      +  +    L
Sbjct: 388 VTALKNTSDFVYL----KVAKPTSMYMNDGYAPPDITNSSSQPVD------NHVSPSSFL 437

Query: 676 AMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
             T A  +     +   + +  I    + + L +GS GLGF+I+  +D        I I 
Sbjct: 438 GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED-----GEGIFIS 492

Query: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786
            ++ GG A+  G L  GDR++ VN V+L  +S E+A  ALK A      +   +P
Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 62/256 (24%), Positives = 106/256 (41%), Gaps = 22/256 (8%)

Query: 1321 SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM----SVF 1376
            S+ V+   E G   +   +R   ++ ++  I+L KG  GLG S+AG      +    S++
Sbjct: 290  SKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIY 349

Query: 1377 IVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
            +  I   GAA KDG+LQI D+LL +N   L   +H+ A + +K     V +   +     
Sbjct: 350  VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK----P 405

Query: 1437 NQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQ------ 1490
              M +  G A   + ++S    +    P+          + +  V    L  D+      
Sbjct: 406  TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPR 465

Query: 1491 --------GGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
                     GLG  I   +   G+ I  +   G A   G L+ GD+I++V+   +     
Sbjct: 466  KVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525

Query: 1543 EKFISLLKTAKMTVKL 1558
            E+  + LK A   V +
Sbjct: 526  EQAAAALKNAGQAVTI 541



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 1456 NLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL------SGVIIK 1509
            N  + ET   V  +DA  +       + + L +   GLG +I+           S + I 
Sbjct: 203  NTDSLETPTYVNGTDADYEY------EEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT 256

Query: 1510 SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQA 1569
             +   G AA DGRL+V D IL V++  V      K +  LK A   V+L +    P S+ 
Sbjct: 257  KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEK 316

Query: 1570 V 1570
            +
Sbjct: 317  I 317


>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
          Length = 926

 Score =  138 bits (347), Expect = 6e-32
 Identities = 109/369 (29%), Positives = 173/369 (46%), Gaps = 63/369 (17%)

Query: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN------DTGVFVS 1752
            +TP  V  T    +A Y+ EE+    T+E   +   GLG SI G  +      D+ +F++
Sbjct: 208  ETPTYVNGT----DADYEYEEI----TLE---RGNSGLGFSIAGGTDNPHIGDDSSIFIT 256

Query: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS 1812
             I+ GG A  DGRL   D IL VN  DVR+ T       LK +   +  +          
Sbjct: 257  KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV--------- 307

Query: 1813 ESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL--GDVPIFIAMMHPTG 1870
                   ++  ++ +I  ++ ++  KG    LG SIAGGVG+    GD  I++  +   G
Sbjct: 308  ------KRRKPVSEKIMEIKLIKGPKG----LGFSIAGGVGNQHIPGDNSIYVTKIIEGG 357

Query: 1871 VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSV------- 1923
             A +  KL++GD+++ +     E +TH +AV  LKN S  + ++V     + +       
Sbjct: 358  AAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPP 417

Query: 1924 -VTGHQQEPASSSLS---FTGLT----------SSSIFQDDLGPPQCKSITLERGPDGLG 1969
             +T    +P  + +S   F G T          S ++  DD    + + + L RG  GLG
Sbjct: 418  DITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLG 477

Query: 1970 FSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILK 2029
            F+IVGG         I++  + A G A   G L++GD+II+VN   L   +HE+A A LK
Sbjct: 478  FNIVGGEDGEG----IFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533

Query: 2030 RTKGTVTLM 2038
                 VT++
Sbjct: 534  NAGQAVTIV 542



 Score =  116 bits (291), Expect = 2e-25
 Identities = 101/326 (30%), Positives = 154/326 (47%), Gaps = 55/326 (16%)

Query: 1630 IEISKGRTGLGLSIVGGSDTLL----GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
            I + +G +GLG SI GG+D        +I I ++   GAA +DGRL   D IL VN +D+
Sbjct: 225  ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284

Query: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743
            R  TH +A+  L++    VRL + R   P  E+     + I+L K P KGLG SI G   
Sbjct: 285  RDVTHSKAVEALKEAGSIVRLYVKR-RKPVSEK----IMEIKLIKGP-KGLGFSIAGGVG 338

Query: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT-QEAVAALLKVSEGS 1798
                  D  ++V+ I++GG A  DG+L  GD++L VN   +   T +EAV AL   S+  
Sbjct: 339  NQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFV 398

Query: 1799 LSSFTFPLS------------GSSTSESLE--------------SSSKKNALASEIQG-- 1830
                  P S             +S+S+ ++              S ++ + ++  + G  
Sbjct: 399  YLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDD 458

Query: 1831 -----LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIV 1885
                  R V + +G T  LG +I GG         IFI+ +   G A  + +LR GDRI+
Sbjct: 459  EITREPRKVVLHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELRKGDRII 513

Query: 1886 TICGTSTEGMTHTQAVNLLKNASGSI 1911
            ++        +H QA   LKNA  ++
Sbjct: 514  SVNSVDLRAASHEQAAAALKNAGQAV 539



 Score =  115 bits (287), Expect = 6e-25
 Identities = 138/637 (21%), Positives = 252/637 (39%), Gaps = 114/637 (17%)

Query: 6   DKNRALHAAERLQTKLRERGDVANEDKLSLLKSVLQSPLFSQILSLQT--SVQQLKDQVN 63
           D  RALH  E  ++KL +  D      +  + ++ QS LF  ++ +Q    V  L +   
Sbjct: 7   DTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKC 66

Query: 64  IATSATSN-IEYAHVPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEF 122
           I  S  S  I+  +   +S     T+ +E+   S +                  P+ +++
Sbjct: 67  IDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLS------------------PSVEKY 108

Query: 123 DQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRD-GR 181
               ++     H+      +  +  +G  +V +  +N  E+     E   G V+H     
Sbjct: 109 RYQDEDTPPQEHISP----QITNEVIGPELVHVSEKNLSEI-----ENVHGFVSHSHISP 159

Query: 182 LKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAAS 241
           +K T+ +L                + ++       +  +   ++PQ   P V  +  +  
Sbjct: 160 IKPTEAVLP-----------SPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLE 208

Query: 242 TISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKA-------TGVIVKTILPGGVADQHG 294
           T +  +        E I L    SGLGF I GG         + + +  I+ GG A Q G
Sbjct: 209 TPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDG 268

Query: 295 RLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSS 354
           RL   D IL++ + D+  ++  +  + L++ G+ V+L + R                   
Sbjct: 269 RLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR------------------- 309

Query: 355 PTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKS 413
                        +K    +  +++L K  +GLG +IAG +G++ +   + I+V  I + 
Sbjct: 310 -------------RKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEG 356

Query: 414 SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSR 473
            A   DG++QIGD+++AV+   L+  T+++AV  L++T   V L + +       +  + 
Sbjct: 357 GAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAP 416

Query: 474 EDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGY-PLLSAEIEEIEDAQK 532
            D+T  +   PV      +N+     FL  T      P     Y P+  A + + E  ++
Sbjct: 417 PDITNSSS-QPV------DNHVSPSSFLGQT------PASPARYSPVSKAVLGDDEITRE 463

Query: 533 QEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGK 592
               +L +    +G N               G GI         FI  +L  GP   SG+
Sbjct: 464 PRKVVLHRGSTGLGFNI---------VGGEDGEGI---------FISFILAGGPADLSGE 505

Query: 593 LFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
           L  GD ++ VN + L   +H+     LK     VT+V
Sbjct: 506 LRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIV 542



 Score =  112 bits (281), Expect = 3e-24
 Identities = 82/232 (35%), Positives = 117/232 (50%), Gaps = 37/232 (15%)

Query: 1812 SESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGD-VPIFIAMMHPT 1869
            ++SLE+ +  N   ++ +    + +++G    LG SIAGG  +P +GD   IFI  +   
Sbjct: 204  TDSLETPTYVNGTDADYE-YEEITLERG-NSGLGFSIAGGTDNPHIGDDSSIFITKIITG 261

Query: 1870 GVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQ 1929
            G AAQ  +LRV D I+ +       +TH++AV  LK A   + + V            ++
Sbjct: 262  GAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV-----------KRR 310

Query: 1930 EPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYV 1987
            +P S  +                      I L +GP GLGFSI GG G+ H  GD  IYV
Sbjct: 311  KPVSEKIM--------------------EIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 350

Query: 1988 KTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
              +   GAA +DG+L+ GD+++AVN   LE VTHEEAV  LK T   V L V
Sbjct: 351  TKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402



 Score =  112 bits (280), Expect = 4e-24
 Identities = 108/382 (28%), Positives = 166/382 (43%), Gaps = 62/382 (16%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +    S+FI  I   GAA +DGRL++ D +L +N
Sbjct: 221  EYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVN 280

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   +H  A   +K A S V++   R K                       +  K  
Sbjct: 281  EVDVRDVTHSKAVEALKEAGSIVRLYVKRRKP----------------------VSEKIM 318

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
            E  +      +  S    V +  +P D              + + +  + E G A  DG+
Sbjct: 319  EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGK 364

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
            L++GD++LAV++  +     E+ ++ LK     V L +    P S  +    G A  +  
Sbjct: 365  LQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV--AKPTSMYMND--GYAPPDIT 420

Query: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIE-----ISKGRT 1637
            NSS     P      P S    + +S PA ++  P +  ++   E T E     + +G T
Sbjct: 421  NSSSQ---PVDNHVSPSSFLGQTPAS-PARYS--PVSKAVLGDDEITREPRKVVLHRGST 474

Query: 1638 GLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVL 1697
            GLG +IVGG D     I I  +   G A   G L  GD+I+ VN +DLR A+H++A   L
Sbjct: 475  GLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAAL 532

Query: 1698 RQTPQRVRLTLYRDEAPYKEEE 1719
            +   Q V +      A Y+ EE
Sbjct: 533  KNAGQAVTIV-----AQYRPEE 549



 Score =  102 bits (253), Expect = 5e-21
 Identities = 106/420 (25%), Positives = 181/420 (43%), Gaps = 88/420 (20%)

Query: 77  VPHLSPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVE 136
           VP  +  ++PT+   +    P   N ++L  P   ++NG  A  E++++           
Sbjct: 181 VPAENTVILPTIPQAN--PPPVLVNTDSLETP--TYVNGTDADYEYEEIT---------- 226

Query: 137 VFELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
               L+  + GLGFS+ G         +  IF+ +I  G  A +DGRL+  D IL +N  
Sbjct: 227 ----LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEV 282

Query: 195 ALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH 254
            + + +TH +A+  L++A   V+L + R                          PV  + 
Sbjct: 283 DV-RDVTHSKAVEALKEAGSIVRLYVKR------------------------RKPVSEKI 317

Query: 255 METIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGD 307
           ME I+L+    GLGF I GG           + V  I+ GG A + G+L  GD +L + +
Sbjct: 318 ME-IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNN 376

Query: 308 TDLAGMSSEQVAQVLRQCGNRVKLMIARGA--------------------IEERTAPTA- 346
             L  ++ E+    L+   + V L +A+                      ++   +P++ 
Sbjct: 377 VCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSF 436

Query: 347 LGITLSS----SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEP 402
           LG T +S    SP S   L  D  T++  +     V L +   GLG  I G  G+   + 
Sbjct: 437 LGQTPASPARYSPVSKAVLGDDEITREPRK-----VVLHRGSTGLGFNIVG--GE---DG 486

Query: 403 SGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
            GIF+  I      +  G ++ GD+II+V+  +L+  +++QA   L++ GQ V +    R
Sbjct: 487 EGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYR 546



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 97/426 (22%), Positives = 171/426 (40%), Gaps = 114/426 (26%)

Query: 1009 INIAKGNSSLGMTVSANKDG------LGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++   D         + +  II GGA ++DGR+ + DCIL +NE   
Sbjct: 225  ITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDV 284

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
              VT+++A   L+                            ++G ++ L     Y  R  
Sbjct: 285  RDVTHSKAVEALK----------------------------EAGSIVRL-----YVKRRK 311

Query: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
            P   +  E                     ++L + P K LG SI GG  +G++   G+  
Sbjct: 312  PVSEKIME---------------------IKLIKGP-KGLGFSIAGG--VGNQHIPGD-- 345

Query: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
              I++  ++E   A K+G L+ GD+++ V+ + L + +HE+AV A++   + V   V   
Sbjct: 346  NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK- 404

Query: 1243 INRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPP 1302
                   P    +++ Y   + +           N+   P  +   P         P  P
Sbjct: 405  -------PTSMYMNDGYAPPDIT-----------NSSSQPVDNHVSPSS--FLGQTPASP 444

Query: 1303 SAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGL 1362
            + +            S +S+ V  +DE              +T E   + L +G +GLG 
Sbjct: 445  ARY------------SPVSKAVLGDDE--------------ITREPRKVVLHRGSTGLGF 478

Query: 1363 SLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAP 1422
            ++ G +D     +FI  I   G A   G L+  D ++ +N   L   SH+ A++ +K A 
Sbjct: 479  NIVGGEDGE--GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAG 536

Query: 1423 SKVKII 1428
              V I+
Sbjct: 537  QAVTIV 542



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 85/286 (29%), Positives = 138/286 (48%), Gaps = 35/286 (12%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DG++ IGD +L++N 
Sbjct: 320  IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNN 376

Query: 1060 ESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF---SS 1116
                 VT+ +A   L+  S     +K+    + ++ +        +     +D     SS
Sbjct: 377  VCLEEVTHEEAVTALKNTSDF-VYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSS 435

Query: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176
            + G+  P  P R     + + L +   +   +PR+V L R  S  LG +IVGG       
Sbjct: 436  FLGQT-PASPARYSPVSK-AVLGDDEITR--EPRKVVLHRG-STGLGFNIVGGE------ 484

Query: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVV 1236
             +GE   GIFI  +L   PA  +G L+ GDRI+ V+ +DLR ASHEQA  A++ AG  V 
Sbjct: 485  -DGE---GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT 540

Query: 1237 FMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
             + Q    RP + S   + +H+L  +   SS +  + SL+ +  ++
Sbjct: 541  IVAQ---YRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRS 583



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 101/406 (24%), Positives = 168/406 (41%), Gaps = 74/406 (18%)

Query: 673  PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
            PVL  TD+ ++   V    A +E   + I LE+G+ GLGFSI    D P     + I I 
Sbjct: 199  PVLVNTDSLETPTYVNGTDADYE--YEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT 256

Query: 732  SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
             ++ GG A +DGRL   D ++ VN+V++ + +  +AVEALK A S  VR+ V +  P+S 
Sbjct: 257  KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGS-IVRLYVKRRKPVSE 315

Query: 792  EEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDS 851
            +                      + +  L +    L G + A  V      + + P ++S
Sbjct: 316  K----------------------IMEIKLIKGPKGL-GFSIAGGVG-----NQHIPGDNS 347

Query: 852  IYSTQASILSLHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQ 910
            IY T+   +   G++  DG L  G  L +      + N C         LEE+  +  + 
Sbjct: 348  IYVTK---IIEGGAAHKDGKLQIGDKLLA------VNNVC---------LEEVTHEEAVT 389

Query: 911  RQDENTPSVDISMGPASGFTIND-YTPANAIEQQYECENTIVWTESHLPSEVISSAELPS 969
                 +  V + +   +   +ND Y P +      +  +  V   S L     S A    
Sbjct: 390  ALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSP 449

Query: 970  VLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGL 1029
            V        S+ +L    +      V+L               +G++ LG  +   +DG 
Sbjct: 450  V--------SKAVLGDDEITREPRKVVLH--------------RGSTGLGFNIVGGEDGE 487

Query: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
            G+ +  I+ GG     G +  GD I+S+N     + ++ QA A L+
Sbjct: 488  GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 64/235 (27%), Positives = 100/235 (42%), Gaps = 27/235 (11%)

Query: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
           GLG S+   VG+         ++  ++  G     GKL  GD+LL VN + L    H++ 
Sbjct: 328 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEA 387

Query: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVL 675
           V  LK     V +    +   PT+    D     DI  +    VD      +  +    L
Sbjct: 388 VTALKNTSDFVYL----KVAKPTSMYMNDGYAPPDITNSSSQPVD------NHVSPSSFL 437

Query: 676 AMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
             T A  +     +   + +  I    + + L +GS GLGF+I+  +D        I I 
Sbjct: 438 GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGED-----GEGIFIS 492

Query: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786
            ++ GG A+  G L  GDR++ VN V+L  +S E+A  ALK A      +   +P
Sbjct: 493 FILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 62/256 (24%), Positives = 106/256 (41%), Gaps = 22/256 (8%)

Query: 1321 SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM----SVF 1376
            S+ V+   E G   +   +R   ++ ++  I+L KG  GLG S+AG      +    S++
Sbjct: 290  SKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIY 349

Query: 1377 IVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
            +  I   GAA KDG+LQI D+LL +N   L   +H+ A + +K     V +   +     
Sbjct: 350  VTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK----P 405

Query: 1437 NQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQ------ 1490
              M +  G A   + ++S    +    P+          + +  V    L  D+      
Sbjct: 406  TSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPR 465

Query: 1491 --------GGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
                     GLG  I   +   G+ I  +   G A   G L+ GD+I++V+   +     
Sbjct: 466  KVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASH 525

Query: 1543 EKFISLLKTAKMTVKL 1558
            E+  + LK A   V +
Sbjct: 526  EQAAAALKNAGQAVTI 541



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 12/121 (9%)

Query: 1456 NLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL------SGVIIK 1509
            N  + ET   V  +DA  +       + + L +   GLG +I+           S + I 
Sbjct: 203  NTDSLETPTYVNGTDADYEY------EEITLERGNSGLGFSIAGGTDNPHIGDDSSIFIT 256

Query: 1510 SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQA 1569
             +   G AA DGRL+V D IL V++  V      K +  LK A   V+L +    P S+ 
Sbjct: 257  KIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEK 316

Query: 1570 V 1570
            +
Sbjct: 317  I 317


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score =  134 bits (337), Expect = 9e-31
 Identities = 147/586 (25%), Positives = 238/586 (40%), Gaps = 130/586 (22%)

Query: 133  RHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
            R + +  L K    GLGF ++G     R +LGIF+  +  G  A  DG LK  D+++++N
Sbjct: 1089 REITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVN 1148

Query: 193  GQALDQTITHQQAISILQKAKDTVQLVIARG--------SLP-----QLVSPIVSRSPSA 239
              +L+  ++H  AI ILQ A + V LVI++         S P     ++ + +   S   
Sbjct: 1149 SVSLEG-VSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQ 1207

Query: 240  ASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSG 299
             S I + S   HW    T+  +++ S   FG  GG         +  G ++ Q  R  S 
Sbjct: 1208 DSAIDSSSKDHHWSR-GTLRHISENS---FGPSGG---------LREGSLSSQDSRTESA 1254

Query: 300  DHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITL-------- 351
                   +   A    +Q  Q   Q G+    +I++   +E    +    T         
Sbjct: 1255 SLSQSQVNGFFASHLGDQTWQE-SQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVT 1313

Query: 352  ----------------SSSPTSTPELRVDASTQKGEE-------------SETFDVELTK 382
                            SS    TP+    +S     +              + F+VEL K
Sbjct: 1314 DYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAK 1373

Query: 383  NVQGLGITIAGYIGDK-----KLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
            N   LGI++   + DK      +   GI+VK++    A E DGRI  GD+++AV+G +L+
Sbjct: 1374 NDNSLGISVT-VLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1432

Query: 438  GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKD 497
            G T++QAVE LR+TGQ V L L+ +G                                  
Sbjct: 1433 GATHKQAVETLRNTGQVVHL-LLEKGQS-------------------------------- 1459

Query: 498  EDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINY--EIVVAH 555
                         PT +E  P+        ++AQ Q    + K  ++   ++  E     
Sbjct: 1460 -------------PTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFE 1506

Query: 556  VSKFSENSGLGISL---------EATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
            V  F  +SGLG S          +       ++ + P  P   SGK+  GD +L+VNG +
Sbjct: 1507 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566

Query: 607  LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIE 652
            L G + Q+V++ L+    EV ++ CR   PP    E+D+  L  ++
Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLLCR--PPPGVLPEIDTALLTPLQ 1610



 Score =  123 bits (309), Expect = 2e-27
 Identities = 152/620 (24%), Positives = 247/620 (39%), Gaps = 106/620 (17%)

Query: 1250 PLPSLLHNLYPKYNFSSTNPFADSL----QINADKAPSQSESEPEK----APLCSVPPPP 1301
            P P  +  L  K +   +   A+SL    ++N  K+ +     PE+    +   S+  P 
Sbjct: 991  PPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPG 1050

Query: 1302 PSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS-GL 1360
             +    M    + +S+S++   + + D     W  +     +   E+ ++ L+K    GL
Sbjct: 1051 QAYVLGMTMHSSGNSSSQVP--LKENDVLHKRWSIV----SSPEREITLVNLKKDAKYGL 1104

Query: 1361 GLSLAGNKDRSRMS--VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSII 1418
            G  + G +   R+   +FI  + P G A  DG L+  D L+ +N   L G SH  A  I+
Sbjct: 1105 GFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEIL 1164

Query: 1419 KCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSF 1478
            + AP  V ++  + K+ ++++   P +    L +  +N   K +       D+A+D SS 
Sbjct: 1165 QNAPEDVTLVISQPKEKISKVPSTPVH----LTNEMKNYMKKSSY----MQDSAIDSSSK 1216

Query: 1479 KN------VQHLELPK--DQGGL--GIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQ 1528
             +      ++H+        GGL  G   S++       +     +G  A+     +GDQ
Sbjct: 1217 DHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASH----LGDQ 1272

Query: 1529 ILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQ-- 1586
                  E   G P    IS     K T K T    N      P  +       +  S   
Sbjct: 1273 TW---QESQHGSPSPSVIS-----KATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMD 1324

Query: 1587 -----SLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGL 1641
                 S    Q+   E  S  NTS       F+S P      PG    +E++K    LG+
Sbjct: 1325 EATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPK----PGDIFEVELAKNDNSLGI 1380

Query: 1642 SIV-----GGSDTLL--GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
            S+      GG +T +  G I +  V  +GAA  DGR+  GD++L VNG+ L  ATH +A+
Sbjct: 1381 SVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV 1440

Query: 1695 NVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK----------- 1743
              LR T Q V L L + ++P  +E V  T    L  +  +G G   V K           
Sbjct: 1441 ETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVT 1500

Query: 1744 ----------RNDTG--------------------VFVSDIVKGGIADADGRLMQGDQIL 1773
                      +N +G                    V V  +  G  A   G++  GD IL
Sbjct: 1501 EENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVIL 1560

Query: 1774 MVNGEDVRNATQEAVAALLK 1793
             VNG  ++  +Q+ V + L+
Sbjct: 1561 KVNGASLKGLSQQEVISALR 1580



 Score =  117 bits (293), Expect = 1e-25
 Identities = 227/1039 (21%), Positives = 381/1039 (36%), Gaps = 226/1039 (21%)

Query: 1090 PAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQP 1149
            P     E   S  +  G+   L +    +G    ++P +E      +++ +  +S  + P
Sbjct: 1034 PERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKE------NDVLHKRWSIVSSP 1087

Query: 1150 RR----VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPG 1205
             R    V L ++    LG  I+GG  MG       +  GIFI  V    PA  +G LKPG
Sbjct: 1088 EREITLVNLKKDAKYGLGFQIIGGEKMG------RLDLGIFISSVAPGGPADLDGCLKPG 1141

Query: 1206 DRI-----VEVDGMD-------LRDASHE------QAVEAIRKAGNPVVFMVQSIINRPR 1247
            DR+     V ++G+        L++A  +      Q  E I K  +  V +   + N  +
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMK 1201

Query: 1248 KSPL--PSLLHNLYPKYNFS-------STNPFADSLQINADKAPSQSESEPEKAPLCSVP 1298
            KS     S + +    +++S       S N F  S  +      SQ +S  E A L    
Sbjct: 1202 KSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQ-DSRTESASLSQSQ 1260

Query: 1299 --------------------PPPPSAFA-----EMGSDHTQSSASK-------------- 1319
                                 P PS  +     E  +D  QS   K              
Sbjct: 1261 VNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1320

Query: 1320 ---------ISQDVDKEDEFGYSWKNIRERYGTLT--------GELHMIELEKGHSGLGL 1362
                      SQD     +   S  N   +    T        G++  +EL K  + LG+
Sbjct: 1321 SDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGI 1380

Query: 1363 SLAGNKDRSRMS-------VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
            S+    D+  ++       +++  + P GAA  DGR+   D +L +NG  L G +H+ A 
Sbjct: 1381 SVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAV 1440

Query: 1416 SIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDL 1475
              ++     V ++  + +   ++  V           N++    ++ + T    D +   
Sbjct: 1441 ETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--F 1498

Query: 1476 SSFKNVQHLELPKDQGGLGIAISEEDTL-------SGVIIKSLTEHGVAATDGRLKVGDQ 1528
             + +N   ++L K+  GLG + S ED L       S V +K L     AA  G++ VGD 
Sbjct: 1499 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1558

Query: 1529 ILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL 1588
            IL V+   + G   ++ IS L+     V L +    P    +P    A     ++ +Q L
Sbjct: 1559 ILKVNGASLKGLSQQEVISALRGTAPEVFLLLC--RPPPGVLPEIDTALLTPLQSPAQVL 1616

Query: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
                  S +P  +  ++ S    +       C   P    +   S G          G D
Sbjct: 1617 PNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKS-PSRRDSYSDSSG---------SGED 1666

Query: 1649 TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL 1708
             L+ A           A      W+              A H    N++ Q         
Sbjct: 1667 DLVTA----------PANISNSTWSS-------------ALHQTLSNMVSQAQSH----- 1698

Query: 1709 YRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQ 1768
               EAP  +E+   T+    QK P K                          D++   + 
Sbjct: 1699 --HEAPKSQEDTICTMFYYPQKIPNKP----------------------EFEDSNPSPLP 1734

Query: 1769 GDQILMVNGEDVRNATQEAVAALL-KVSEGSLSSFTFPLSGSSTSESLESSSKKNALASE 1827
             D   M  G+  +  ++ A ++ + K     +S  T   + +     LE+  +   L  E
Sbjct: 1735 PD---MAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVE 1791

Query: 1828 IQGLRTVEMKKGPTDSLGISIAGG---VGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRI 1884
            +  +  ++ +KG   SLG ++  G   +G  + DV     +  P   A    +L+ GDR+
Sbjct: 1792 LL-ITLIKSEKG---SLGFTVTKGNQRIGCYVHDV-----IQDP---AKSDGRLKPGDRL 1839

Query: 1885 VTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSS 1944
            + +  T    MTHT AVNLL+ AS ++ +          V G   E              
Sbjct: 1840 IKVNDTDVTNMTHTDAVNLLRAASKTVRL----------VIGRVLE-------------- 1875

Query: 1945 SIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKR 2004
             + +  + P     ITL    + LGFS+ GG+ S +    +Y+  +  +  A+ +G L+ 
Sbjct: 1876 -LPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ--VVYISDINPRSVAAIEGNLQL 1932

Query: 2005 GDQIIAVNGQSLEGVTHEE 2023
             D I  VNG S +G+T EE
Sbjct: 1933 LDVIHYVNGVSTQGMTLEE 1951



 Score =  108 bits (270), Expect = 5e-23
 Identities = 176/888 (19%), Positives = 344/888 (38%), Gaps = 173/888 (19%)

Query: 266  GLGFGIIGGKATG-----VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
            GLGF IIGG+  G     + + ++ PGG AD  G L  GD ++ +    L G+S     +
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162

Query: 321  VLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTS-TPELRVDASTQKGEESETFDVE 379
            +L+     V L+I++   +    P        S+P   T E++         +    D  
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVP--------STPVHLTNEMKNYMKKSSYMQDSAIDSS 1214

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
               +    G     +I +    PSG     + + S    D R +      ++  + + GF
Sbjct: 1215 SKDHHWSRGTL--RHISENSFGPSG----GLREGSLSSQDSRTESA----SLSQSQVNGF 1264

Query: 440  ----TNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYE 495
                   Q  +  +H   +   +++ +  ++E    S +  TK   +S V     + + +
Sbjct: 1265 FASHLGDQTWQESQHGSPSP--SVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSD 1322

Query: 496  KDEDFLSSTRN---------TNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMG 546
             DE   SS+++         +++  + +  +   S+   +  D  + E   L K    +G
Sbjct: 1323 MDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVE---LAKNDNSLG 1379

Query: 547  INYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGIT 606
            I+  ++      F +    G++     G  ++++V+P+G     G++  GD +L VNG++
Sbjct: 1380 ISVTVL------FDKG---GVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVS 1430

Query: 607  LLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
            L G  H+  V  L+    +V  +   +   PT++  +     C +               
Sbjct: 1431 LEGATHKQAVETLRNTG-QVVHLLLEKGQSPTSKEHVPVTPQCTLS------------DQ 1477

Query: 667  SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL--DYQDPIDPA 724
            +++ + P     +  + T +V+    + E     ++L K S GLGFS    D   P    
Sbjct: 1478 NAQGQGP-----EKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQIN 1532

Query: 725  STVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA---------- 774
            ++++ ++ L PG  A + G++  GD ++ VN  +L+  S +E + AL+G           
Sbjct: 1533 ASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592

Query: 775  -PSGTV-RIGVAKPLPL-SPEEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTN 831
             P G +  I  A   PL SP +   ++ +DS      SC E                 ++
Sbjct: 1593 PPPGVLPEIDTALLTPLQSPAQVLPNSSKDS---SQPSCVEQS-------------TSSD 1636

Query: 832  DADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCD 891
            + ++ D+S  +       DS           +  S G G +   + P++       ++  
Sbjct: 1637 ENEMSDKSKKQCKSPSRRDS-----------YSDSSGSGEDDLVTAPANISNSTWSSA-- 1683

Query: 892  PVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIV 951
                LH +L  + +Q     +                          A + Q +   T+ 
Sbjct: 1684 ----LHQTLSNMVSQAQSHHE--------------------------APKSQEDTICTMF 1713

Query: 952  WTESHLPSEVISSAELPSVLPDSAGKGSEYLLE-QSSLACNAECVMLQNVSK-------- 1002
            +    +P++       PS LP     G  Y  + +S+ + + +   + ++S+        
Sbjct: 1714 YYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWT 1773

Query: 1003 ----------ESFERTIN-----IAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGR 1047
                      E FE  +      I     SLG TV+     +G  V  +I   A S DGR
Sbjct: 1774 PLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKS-DGR 1832

Query: 1048 IAIGDCILSINEESTISVTNAQARAMLRRHS-----LIGPDIKITYVP 1090
            +  GD ++ +N+    ++T+  A  +LR  S     +IG  +++  +P
Sbjct: 1833 LKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIP 1880



 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 159/708 (22%), Positives = 273/708 (38%), Gaps = 141/708 (19%)

Query: 1161 SLGISIV---GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLR 1217
            SLGIS+       G+ + + +G    GI++K V+    A  +G +  GDR++ V+G+ L 
Sbjct: 1377 SLGISVTVLFDKGGVNTSVRHG----GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLE 1432

Query: 1218 DASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQIN 1277
             A+H+QAVE +R  G  V                                      L + 
Sbjct: 1433 GATHKQAVETLRNTGQVV-------------------------------------HLLLE 1455

Query: 1278 ADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNI 1337
              ++P+  E          VP  P    ++  +        K+ +    +D    + +N 
Sbjct: 1456 KGQSPTSKEH---------VPVTPQCTLSDQNAQG--QGPEKVKKTTQVKDYSFVTEENT 1504

Query: 1338 RERYGTLTGELHMIELEKGHSGLGLSLA--GNKDRSRMSVFIVGID---PNGAAGKDGRL 1392
             E           ++L K  SGLG S +   N    +++  IV +    P   A + G++
Sbjct: 1505 FE-----------VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKI 1553

Query: 1393 QIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPS 1452
             + D +L++NG  L G S Q   S ++    +V ++  R    V  +       + PL S
Sbjct: 1554 DVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGV--LPEIDTALLTPLQS 1611

Query: 1453 NSENLQNKE---TEPTVTTSDAAVDLS--SFKNVQHLELPK------DQGGLGIAISEED 1501
             ++ L N     ++P+      + D +  S K+ +  + P       D  G G    E+D
Sbjct: 1612 PAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSG----EDD 1667

Query: 1502 TLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIH 1561
             ++     S +    A       +  Q  +  +      P  +  ++        K+   
Sbjct: 1668 LVTAPANISNSTWSSALHQTLSNMVSQAQSHHEA-----PKSQEDTICTMFYYPQKIPNK 1722

Query: 1562 AENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPAT-- 1619
             E  DS   P     A G            QS  P+ ES  ++S         S+P    
Sbjct: 1723 PEFEDSNPSPLPPDMAPG------------QSYQPQSESASSSSMDKYHIHHISEPTRQE 1770

Query: 1620 --CPIIPGCETTIE------------ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAA 1665
               P+    E  +E            I   +  LG ++  G+  +     +H+V ++ A 
Sbjct: 1771 NWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRI--GCYVHDVIQDPAK 1828

Query: 1666 CKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR----DEAPYKEEEVC 1721
              DGRL  GD++++VN  D+   TH +A+N+LR   + VRL + R       P     + 
Sbjct: 1829 -SDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLP 1887

Query: 1722 D-TLTIELQKKPGKGLGLSIVGKRND--TGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
            D TLT   ++     LG S+ G  +     V++SDI    +A  +G L   D I  VNG 
Sbjct: 1888 DITLTCNKEE-----LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGV 1942

Query: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALAS 1826
              +  T E V   L +S  SL      L  +     +  SSK++A+++
Sbjct: 1943 STQGMTLEEVNRALDMSLPSL-----VLKATRNDLPVVPSSKRSAVSA 1985



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 75/274 (27%), Positives = 127/274 (46%), Gaps = 30/274 (10%)

Query: 258  IELVNDGSGLGFGII-----GGKAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGD 307
            +EL  + + LG  +      GG  T     G+ VK ++P G A+  GR+  GD +L +  
Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428

Query: 308  TDLAGMSSEQVAQVLRQCGNRVKLMIARG--AIEERTAPTALGITLS--SSPTSTPELRV 363
              L G + +Q  + LR  G  V L++ +G     +   P     TLS  ++    PE +V
Sbjct: 1429 VSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE-KV 1487

Query: 364  DASTQKGE-----ESETFDVELTKNVQGLGITIA--GYIGDKKLEPSGIFVKSITKSSAV 416
              +TQ  +     E  TF+V+L KN  GLG + +    +  +++  S + VK +      
Sbjct: 1488 KKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPA 1547

Query: 417  EHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR--RGMKQEAE----- 469
               G+I +GD I+ V+G +L+G + Q+ +  LR T   V L L R   G+  E +     
Sbjct: 1548 AESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLT 1607

Query: 470  -LMSREDVTKDADLSPVNASIIKENYEKDEDFLS 502
             L S   V  ++       S ++++   DE+ +S
Sbjct: 1608 PLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMS 1641



 Score = 89.7 bits (221), Expect = 3e-17
 Identities = 153/624 (24%), Positives = 244/624 (39%), Gaps = 101/624 (16%)

Query: 667  SSETEDP----VLAMTDAGQSTEEVQAPLA-------MW------EAGIQHIELEKGSK- 708
            SS  EDP    VL MT         Q PL         W      E  I  + L+K +K 
Sbjct: 1043 SSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKY 1102

Query: 709  GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAV 768
            GLGF I+   + +      I I S+ PGG A+ DG L PGDRL+ VN V+LE  S   A+
Sbjct: 1103 GLGFQIIG-GEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAI 1161

Query: 769  EALKGAPSGTVRIGVAKP------LPLSP----EEGYVSAKEDSFLYPPHSCEEAGLADK 818
            E L+ AP   V + +++P      +P +P     E     K+ S  Y   S  ++   D 
Sbjct: 1162 EILQNAPE-DVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSS--YMQDSAIDSSSKDH 1218

Query: 819  PLFRADLALVGTND---ADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGS 875
               R  L  +  N    +  + E +  S  S   +S   +Q+ +     S  GD   +  
Sbjct: 1219 HWSRGTLRHISENSFGPSGGLREGSLSSQDS-RTESASLSQSQVNGFFASHLGD-QTWQE 1276

Query: 876  SLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYT 935
            S   SP   VI  + +         +E +T +        T    IS        + DY+
Sbjct: 1277 SQHGSPSPSVISKATE---------KETFTDS----NQSKTKKPGIS-------DVTDYS 1316

Query: 936  PANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECV 995
                 +     E T   ++ H   +  SS+   SV   +      +           E  
Sbjct: 1317 DRGDSDMD---EATYSSSQDHQTPKQESSS---SVNTSNKMNFKTFSSSPPKPGDIFEVE 1370

Query: 996  MLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCIL 1055
            + +N +      T+   KG    G+  S    G+   V+++I  GA   DGRI  GD +L
Sbjct: 1371 LAKNDNSLGISVTVLFDKG----GVNTSVRHGGI--YVKAVIPQGAAESDGRIHKGDRVL 1424

Query: 1056 SINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFS 1115
            ++N  S    T+ QA   LR    +            HL    +  GQ       + +  
Sbjct: 1425 AVNGVSLEGATHKQAVETLRNTGQV-----------VHL---LLEKGQSPTSKEHVPVTP 1470

Query: 1116 SYTGRDIPELPEREEGEGEESELQNTAYSNWN-----QPRRVELWREPSKSLGISIVGGR 1170
              T  D     +  +G+G E   + T   +++         V+L++  S  LG S     
Sbjct: 1471 QCTLSD-----QNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKN-SSGLGFSFSRED 1524

Query: 1171 GMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRK 1230
             +     N  ++R   +K +    PA ++G +  GD I++V+G  L+  S ++ + A+R 
Sbjct: 1525 NLIPEQINASIVR---VKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRG 1581

Query: 1231 AGNPVVFMVQSIINRPRKSPLPSL 1254
               P VF+   ++ RP    LP +
Sbjct: 1582 TA-PEVFL---LLCRPPPGVLPEI 1601



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 156/701 (22%), Positives = 264/701 (37%), Gaps = 131/701 (18%)

Query: 164  GIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIARG 223
            GI+V+ +     A  DGR+ + D++LA+NG +L+   TH+QA+  L+     V L++ +G
Sbjct: 1399 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGA-THKQAVETLRNTGQVVHLLLEKG 1457

Query: 224  SLPQL-----VSPIVSRSPSAA----------STISAHSNPVHWQHMETIELVNDGSGLG 268
              P       V+P  + S   A          +T     + V  ++   ++L  + SGLG
Sbjct: 1458 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLG 1517

Query: 269  FGIIGG--------KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQ 320
            F              A+ V VK + PG  A + G++  GD ILK+    L G+S ++V  
Sbjct: 1518 FSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVIS 1577

Query: 321  VLRQCGNRVKLMIAR---GAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFD 377
             LR     V L++ R   G + E    TAL   L S     P    D+S     E  T  
Sbjct: 1578 ALRGTAPEVFLLLCRPPPGVLPE--IDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSS 1635

Query: 378  VELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQ 437
             E   + +      +    D   + SG     +  + A      I       A+  T   
Sbjct: 1636 DENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPA-----NISNSTWSSALHQTLSN 1690

Query: 438  GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIK-ENYEK 496
              +  Q+      + +  + T+     K     +  +   +D++ SP+   +   ++Y+ 
Sbjct: 1691 MVSQAQSHHEAPKSQEDTICTMFYYPQK-----IPNKPEFEDSNPSPLPPDMAPGQSYQP 1745

Query: 497  DEDFLSSTRNTNI------LPTEEEGYPLLSAEIE-EIEDAQKQEAALLTKWQRIMGINY 549
              +  SS+            PT +E +  L  ++E  +ED + +   L+T  +       
Sbjct: 1746 QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIK------- 1798

Query: 550  EIVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGI 605
                      SE   LG ++  T G+     ++  V+ + P    G+L  GD L++VN  
Sbjct: 1799 ----------SEKGSLGFTV--TKGNQRIGCYVHDVI-QDPAKSDGRLKPGDRLIKVNDT 1845

Query: 606  TLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFI 665
             +    H D VN+L+     V +V  R             L+L  I +   PH+      
Sbjct: 1846 DVTNMTHTDAVNLLRAASKTVRLVIGR------------VLELPRIPML--PHL------ 1885

Query: 666  GSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAS 725
                                            +  I L    + LGFS+    D +    
Sbjct: 1886 --------------------------------LPDITLTCNKEELGFSLCGGHDSL---Y 1910

Query: 726  TVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAK 785
             V+ I  + P  +A  +G L   D + +VN V+ +  +LEE   AL  +    V      
Sbjct: 1911 QVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRN 1970

Query: 786  PLPLSP--EEGYVSAKED---SFLYPPHSCEEAGLADKPLF 821
             LP+ P  +   VSA +    +  Y   SC +  L     F
Sbjct: 1971 DLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSF 2011



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 119/514 (23%), Positives = 191/514 (37%), Gaps = 117/514 (22%)

Query: 1628 TTIEISK-GRTGLGLSIVGGSDT--LLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGID 1684
            T + + K  + GLG  I+GG     L   I I  V   G A  DG L  GD+++ VN + 
Sbjct: 1092 TLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVS 1151

Query: 1685 ------------LRKATHD---------EAINVLRQTPQRV--RLTLYRDEAPYKEEEVC 1721
                        L+ A  D         E I+ +  TP  +   +  Y  ++ Y ++   
Sbjct: 1152 LEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAI 1211

Query: 1722 DTLT-------------IELQKKPGKGL---GLSIVGKRNDTGVFVSDIVKGGIADADG- 1764
            D+ +              E    P  GL    LS    R ++       V G  A   G 
Sbjct: 1212 DSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGD 1271

Query: 1765 RLMQGDQILMVNGEDVRNATQEA-----------------VAALLKVSEGSLSSFTFPLS 1807
            +  Q  Q    +   +  AT++                  V       +  +   T+  S
Sbjct: 1272 QTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSS 1331

Query: 1808 GSSTSESLESSSKKNALASEIQGLRT-------------VEMKKGPTDSLGISIA----- 1849
                +   ESSS  N   S     +T             VE+ K   +SLGIS+      
Sbjct: 1332 QDHQTPKQESSSSVNT--SNKMNFKTFSSSPPKPGDIFEVELAKND-NSLGISVTVLFDK 1388

Query: 1850 GGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG 1909
            GGV + +    I++  + P G A    ++  GDR++ + G S EG TH QAV  L+N   
Sbjct: 1389 GGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQ 1448

Query: 1910 SIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSIT--------- 1960
             + + +  G      T  +  P +   + +   +        GP + K  T         
Sbjct: 1449 VVHLLLEKG---QSPTSKEHVPVTPQCTLSDQNAQG-----QGPEKVKKTTQVKDYSFVT 1500

Query: 1961 --------LERGPDGLGFSIVGGYGSPHGDLP-------IYVKTVFAKGAASEDGRLKRG 2005
                    L +   GLGFS    +      +P       + VK +F    A+E G++  G
Sbjct: 1501 EENTFEVKLFKNSSGLGFS----FSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVG 1556

Query: 2006 DQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            D I+ VNG SL+G++ +E ++ L+ T   V L++
Sbjct: 1557 DVILKVNGASLKGLSQQEVISALRGTAPEVFLLL 1590



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 40/225 (17%)

Query: 110  IPHINGKPACDEFDQLIKNMAQGRHVEVFEL--------LKPPSGGLGFSVVGLRSENRG 161
            I HI+ +P   E    +KN  +  H+E FEL        +K   G LGF+V    ++   
Sbjct: 1760 IHHIS-EPTRQENWTPLKNDLEN-HLEDFELEVELLITLIKSEKGSLGFTV----TKGNQ 1813

Query: 162  ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQLVIA 221
             +G +V ++ +   A  DGRLK  D+++ +N   +   +TH  A+++L+ A  TV+LVI 
Sbjct: 1814 RIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTN-MTHTDAVNLLRAASKTVRLVIG 1871

Query: 222  RG-SLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKAT--- 277
            R   LP++                    P+    +  I L  +   LGF + GG  +   
Sbjct: 1872 RVLELPRI--------------------PMLPHLLPDITLTCNKEELGFSLCGGHDSLYQ 1911

Query: 278  GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322
             V +  I P  VA   G L   D I  +      GM+ E+V + L
Sbjct: 1912 VVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRAL 1956



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 52/200 (26%), Positives = 94/200 (47%), Gaps = 22/200 (11%)

Query: 314  SSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDA-------- 365
            +S+ VA  L +   R K      +IE+      LG+T+ SS  S+ ++ +          
Sbjct: 1023 NSKSVAS-LNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRW 1081

Query: 366  STQKGEESETFDVELTKNVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQI 424
            S     E E   V L K+ + GLG  I G     +L+  GIF+ S+      + DG ++ 
Sbjct: 1082 SIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLD-LGIFISSVAPGGPADLDGCLKP 1140

Query: 425  GDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSP 484
            GD++I+V+  +L+G ++  A+E+L++  + V L +      Q  E +S+   T      P
Sbjct: 1141 GDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI-----SQPKEKISKVPST------P 1189

Query: 485  VNASIIKENYEKDEDFLSST 504
            V+ +   +NY K   ++  +
Sbjct: 1190 VHLTNEMKNYMKKSSYMQDS 1209



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 37/156 (23%), Positives = 72/156 (46%), Gaps = 5/156 (3%)

Query: 1765 RLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS-----ESLESSS 1819
            +L     +  +N    R   +   +++    +  +   T   SG+S+S     E+     
Sbjct: 1020 KLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHK 1079

Query: 1820 KKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
            + + ++S  + +  V +KK     LG  I GG      D+ IFI+ + P G A     L+
Sbjct: 1080 RWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLK 1139

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQV 1915
             GDR++++   S EG++H  A+ +L+NA   + + +
Sbjct: 1140 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 47/177 (26%), Positives = 75/177 (42%), Gaps = 27/177 (15%)

Query: 471  MSRED------VTK---DADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLS 521
            MSR D      VTK      ++ +N S  +  +E D   +       +L     G  + S
Sbjct: 1007 MSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVL-----GMTMHS 1061

Query: 522  AEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH----- 576
            +     +   K+   L  +W  +     EI + ++ K ++  GLG  +   +G       
Sbjct: 1062 SGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKY-GLGFQI---IGGEKMGRL 1117

Query: 577  ----FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
                FI SV P GP    G L  GD L+ VN ++L G +H   + IL+  P +VT+V
Sbjct: 1118 DLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLV 1174



 Score = 45.1 bits (105), Expect = 7e-04
 Identities = 31/82 (37%), Positives = 45/82 (54%), Gaps = 6/82 (7%)

Query: 1959 ITLERGPDG-LGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
            ITL +   G LGF++  G    +  +  YV  V    A S DGRLK GD++I VN   + 
Sbjct: 1794 ITLIKSEKGSLGFTVTKG----NQRIGCYVHDVIQDPAKS-DGRLKPGDRLIKVNDTDVT 1848

Query: 2018 GVTHEEAVAILKRTKGTVTLMV 2039
             +TH +AV +L+    TV L++
Sbjct: 1849 NMTHTDAVNLLRAASKTVRLVI 1870



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 31/138 (22%), Positives = 57/138 (41%), Gaps = 18/138 (13%)

Query: 1360 LGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNA----- 1414
            LG SL G  D     V+I  I+P   A  +G LQ+ D +  +NG    G + +       
Sbjct: 1898 LGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALD 1957

Query: 1415 ----SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSD 1470
                S ++K   + + ++    + AV+      GN    + S S        +P +T +D
Sbjct: 1958 MSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCS--------QPALTPND 2009

Query: 1471 AAVDLSSFKNVQHLELPK 1488
            +   ++  + +  +  PK
Sbjct: 2010 SFSTVAG-EEINEISYPK 2026


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score =  131 bits (330), Expect = 6e-30
 Identities = 196/845 (23%), Positives = 334/845 (39%), Gaps = 116/845 (13%)

Query: 941  EQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNV 1000
            +QQ + + T  WTE H       SA +P V+P+      E   E   +    +    +N 
Sbjct: 414  QQQQQQQQTEEWTEDH-------SALVPPVIPNHPPSNPEPARE---VPLQGKPFFTRNP 463

Query: 1001 S--KESFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSI 1057
            S  K  F  T  + K +   G TV    +    + ++S++  G  + DG++  GD I+S+
Sbjct: 464  SELKGKFIHT-KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522

Query: 1058 NEESTISVTNAQARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSG 1106
            N+   +  T+AQ   + +    IG  + +              P   L      L ++  
Sbjct: 523  NDTCVLGHTHAQVVKIFQSIP-IGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPI 581

Query: 1107 RVMALDIF------SSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSK 1160
             V   + +      SS TG+       R     + +   +  Y N        +  +P  
Sbjct: 582  IVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPEL 641

Query: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
                 + G  G G  +++     G  +K ++ DSP  +   LK GD IVEV+  +++  +
Sbjct: 642  ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALT 698

Query: 1221 HEQAVEAIRKA--GNPVVFMVQ-SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQIN 1277
            H Q V+ + +   G+ V  +VQ   +  P+KSP    L     K + +S+     S +  
Sbjct: 699  HNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLER---KDSQNSSQHSVSSHRSL 755

Query: 1278 ADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNI 1337
               +PS S           V P  P A A+   D T SS  K      K D F   W   
Sbjct: 756  HTASPSHSTQ---------VLPEFPPAEAQ-APDQTDSSGQK------KPDPFKI-WAQS 798

Query: 1338 RERYGTLTGELHM--IELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIA 1395
            R  Y     +     I L +  +G G  + G  +     ++I  I P GAA  DGRL+  
Sbjct: 799  RSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGE-PIYIGHIVPLGAADTDGRLRSG 857

Query: 1396 DELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSE 1455
            DEL+ ++G  + G+SHQ    +++ A  +  +     +  V   AV       P P++S 
Sbjct: 858  DELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV--FAVPKTENEVPSPASSH 915

Query: 1456 NLQNKE---TEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLG---------------IAI 1497
            +  N+    TE   T   +   L++  +          GG G               I  
Sbjct: 916  HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRR 975

Query: 1498 SEEDTLSGVIIKSLT-----------------------EHGVAATDGRLKVGDQILAVDD 1534
             E +    VI+ S++                       E   A   G+LKVGD+ILAV+ 
Sbjct: 976  GENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNG 1035

Query: 1535 EIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSG 1594
              +        ++L+K A  TV L I         +P    + +    N+ +   +  + 
Sbjct: 1036 CSITNKSHSDIVNLIKEAGNTVTLRI---------IPGDESSNATLLTNAEKIATITTTH 1086

Query: 1595 SPEPESIRNTSRSSTPAIFASDPATCPIIPGCET--TIEISKGRTGLGLSIVGGSDTLLG 1652
            +P  +  + T  ++ P   +      P     +   T+E+ +G  G G S+ GG +  + 
Sbjct: 1087 TPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMD 1146

Query: 1653 AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDE 1712
              ++  + E+G A + G++  GD+ILE+NG   +   H  AI +++   +RVRL L R +
Sbjct: 1147 LYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGD 1205

Query: 1713 APYKE 1717
                E
Sbjct: 1206 GSVPE 1210



 Score =  108 bits (271), Expect = 4e-23
 Identities = 174/815 (21%), Positives = 320/815 (39%), Gaps = 156/815 (19%)

Query: 700  HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNL 759
            H +L K S+G GF+++   +P +     + I+SLV  G A  DG++  GD ++ VND  +
Sbjct: 472  HTKLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527

Query: 760  ENSSLEEAVEALKGAPSGT---VRIGVAKPLPLSPEEGYVSAKEDSFLY--PPHSCEEAG 814
               +  + V+  +  P G    + +    PLP  P++   S      +    P       
Sbjct: 528  LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587

Query: 815  LADKPLFRADLA--LVGTND------ADLVDESTFESPYSPENDSI-----YSTQASILS 861
              D P   +     + G  D      AD+   S+   P    ND++      +TQ  +++
Sbjct: 588  TYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP----NDTVSLASSIATQPELIT 643

Query: 862  LHGSSCGDGLNYGSSLPSSP------PKDVIEN-------SCDPVLDLHMSLEELYTQNL 908
            +H       + +G ++  SP       K ++++         D +++++    +  T N 
Sbjct: 644  VH--IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701

Query: 909  LQRQDENTP--SVDISMGPASGFTINDYTPANAIEQQYECENTIVWT-ESHLPSEVISSA 965
            +       P  S    +    G  +   +P +   ++ + +N+   +  SH      S +
Sbjct: 702  VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761

Query: 966  ELPSVLP-------------DSAG--KGSEYLLEQSSLACNAECVMLQNVSKESFERTIN 1010
                VLP             DS+G  K   + +   S +      M +N   +  E+ I 
Sbjct: 762  HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRS------MYENRLPDYQEQDIF 815

Query: 1011 IAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS----- 1064
            + +  +  G  +   N+ G  + +  I+  GA   DGR+  GD ++ ++    I      
Sbjct: 816  LWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 875

Query: 1065 VTNAQARAMLRRHSLIGPDIKITYV--------------------PAEHLEEFKISLGQQ 1104
            V     +A  + H  +    K+ +                     PA   EE +   G Q
Sbjct: 876  VVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQ 935

Query: 1105 SGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLG- 1163
            +    +L+  SS +G           G G      +   S   QP  VE+ R  ++  G 
Sbjct: 936  N----SLNTVSSGSG--------STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGF 983

Query: 1164 --ISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
              +S V     G+   N  V     I  ++E SPA + G LK GDRI+ V+G  + + SH
Sbjct: 984  VIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSH 1043

Query: 1222 EQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
               V  I++AGN V   +           +P             S+N    +L  NA+K 
Sbjct: 1044 SDIVNLIKEAGNTVTLRI-----------IP----------GDESSNA---TLLTNAEKI 1079

Query: 1282 PSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERY 1341
                      A + +   P     ++ G+  T+++         +E +F +     +   
Sbjct: 1080 ----------ATITTTHTP-----SQQGTQETRNTTKP-----KQESQFEF-----KAPQ 1114

Query: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEI 1401
             T   + + +ELE+G  G G SL G ++ + M ++++ +  +G A + G+++I DE+LEI
Sbjct: 1115 ATQEQDFYTVELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKMRIGDEILEI 1173

Query: 1402 NGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
            NG+      H  A  +IK    +V++   R   +V
Sbjct: 1174 NGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV 1208



 Score =  108 bits (269), Expect = 7e-23
 Identities = 151/656 (23%), Positives = 274/656 (41%), Gaps = 117/656 (17%)

Query: 189  LAINGQ-ALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHS 247
            + +NGQ   D   +H      +   KD      AR S P  V+   S       T+S  S
Sbjct: 581  IIVNGQETYDSPASHSSKTGKVNGMKD------ARPSSPADVASNSSHG-YPNDTVSLAS 633

Query: 248  NPVHWQHMETIELVNDGSGLGFGII-----GGKATGVIVKTILPGGVADQHGRLCSGDHI 302
            +      + T+ +V    G GF I      GG+    IV +    G+ +       GD I
Sbjct: 634  SIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKE-------GDLI 686

Query: 303  LKIGDTDLAGMSSEQVAQVLRQC--GNRVKLMIARGAI------------EERTAPTALG 348
            +++   ++  ++  QV  +L +C  G+ V L++ RG +            E + +  +  
Sbjct: 687  VEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ 746

Query: 349  ITLSS-------SPTSTPEL-------------RVDASTQKGEES--------------- 373
             ++SS       SP+ + ++             + D+S QK  +                
Sbjct: 747  HSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRL 806

Query: 374  ---ETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
               +  D+ L +   G G  I G  G++  EP  I++  I    A + DGR++ GD++I 
Sbjct: 807  PDYQEQDIFLWRKETGFGFRILG--GNEPGEP--IYIGHIVPLGAADTDGRLRSGDELIC 862

Query: 431  VDGTNLQGFTNQQAVEVLRHTGQT--VLLTLMRRGM----KQEAELMSREDVTKDADLSP 484
            VDGT + G ++Q  V++++   +   V LT+ R+ +    K E E+ S       ++  P
Sbjct: 863  VDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN-QP 921

Query: 485  VNASIIKENYEKDEDFL----SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTK 540
             + +  K   +  ++ L    S + +T+ + +   G   + + + +  D + +       
Sbjct: 922  ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRG----- 976

Query: 541  WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELL 600
                 G  + ++V+ VS+    +  G +  A    H I  ++   P    GKL  GD +L
Sbjct: 977  --ENEGFGF-VIVSSVSRPEAGTTFGNACVAMP--HKIGRIIEGSPADRCGKLKVGDRIL 1031

Query: 601  EVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL----DLCDIELTEK 656
             VNG ++  ++H D+VN++KE    VT+    R +P    S    L     +  I  T  
Sbjct: 1032 AVNGCSITNKSHSDIVNLIKEAGNTVTL----RIIPGDESSNATLLTNAEKIATITTTHT 1087

Query: 657  PHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILD 716
            P        G+ ET +         +S  E +AP A  E     +ELE+G+KG GFS+  
Sbjct: 1088 PSQQ-----GTQETRN---TTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRG 1139

Query: 717  YQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
             ++     +  + +  L   G AE+ G++  GD ++ +N    +N     A+E +K
Sbjct: 1140 GRE----YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1191



 Score =  100 bits (250), Expect = 1e-20
 Identities = 95/413 (23%), Positives = 168/413 (40%), Gaps = 91/413 (22%)

Query: 1707 TLYRDEAP-YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG--VFVSDIVKGGIADAD 1763
            ++Y +  P Y+E+++       L +K   G G  I+G  N+ G  +++  IV  G AD D
Sbjct: 800  SMYENRLPDYQEQDIF------LWRKE-TGFGFRILGG-NEPGEPIYIGHIVPLGAADTD 851

Query: 1764 GRLMQGDQILMVNGEDVRNATQEAVAALL------------------------------- 1792
            GRL  GD+++ V+G  V   + + V  L+                               
Sbjct: 852  GRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSP 911

Query: 1793 -----------------KVSEGSLSSFTFPLSGSSTSESLESSSKKNA-LASEIQGLRTV 1834
                             +  +GS +S     SGS ++  + S     + + S +     V
Sbjct: 912  ASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDV 971

Query: 1835 EMKKGPTDSLGISIAGGVGSPLGDVPI---FIAMMHPTG------VAAQTQKLRVGDRIV 1885
            E+++G  +  G  I   V  P          +AM H  G       A +  KL+VGDRI+
Sbjct: 972  EIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRIL 1031

Query: 1886 TICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVS-------------VVTGHQQEPA 1932
             + G S    +H+  VNL+K A  ++ ++++ G + S             + T H     
Sbjct: 1032 AVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1091

Query: 1933 SSSLSFTGLTSSSIFQDDLGPPQCK------SITLERGPDGLGFSIVGGYGSPHGDLPIY 1986
             +  +          Q +   PQ        ++ LERG  G GFS+ GG      ++ +Y
Sbjct: 1092 GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG---REYNMDLY 1148

Query: 1987 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            V  +   G A   G+++ GD+I+ +NG++ + + H  A+ ++K     V L +
Sbjct: 1149 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1201



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 143/652 (21%), Positives = 249/652 (38%), Gaps = 155/652 (23%)

Query: 1483 HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYP 1541
            H +L K   G G  +   D     + IKSL   G AA DG+++ GD I++V+D  V+G+ 
Sbjct: 472  HTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531

Query: 1542 IEKFISLLKTAKMTVKLTIHA-------ENPDSQAVPSAAGAASGEKK----NSSQSLMV 1590
              + + + ++  +   + +          +PD          A  +K+    N  ++   
Sbjct: 532  HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591

Query: 1591 PQSGSPEPESIRNT--SRSSTPAIFASDPA------TCPIIPGCET-----TIEISKGRT 1637
            P S S +   +     +R S+PA  AS+ +      T  +     T     T+ I KG  
Sbjct: 592  PASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPM 651

Query: 1638 GLGLSIV---GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
            G G +I    GG    +  I+      +   C+   L  GD I+EVN  +++  TH++ +
Sbjct: 652  GFGFTIADSPGGGGQRVKQIV------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVV 703

Query: 1695 NVLRQTPQ--RVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVS 1752
            ++L + P+   V L + R   P             + KK  K   L              
Sbjct: 704  DMLVECPKGSEVTLLVQRGGLP-------------VPKKSPKSQPLE------------- 737

Query: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFT-----FPLS 1807
                                     +D +N++Q +V++   +   S S  T     FP +
Sbjct: 738  ------------------------RKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPA 773

Query: 1808 GSSTSESLESSSKKNALASEIQGL-RTVEMKKGPT------------DSLGISIAGGVGS 1854
             +   +  +SS +K     +I    R++   + P                G  I GG  +
Sbjct: 774  EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG--N 831

Query: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG----- 1909
              G+ PI+I  + P G A    +LR GD ++ + GT   G +H   V L++ A+      
Sbjct: 832  EPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890

Query: 1910 -SIEMQVV------------------AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD 1950
             ++  +VV                  +    + +T  ++ P  S  S   ++S S     
Sbjct: 891  LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950

Query: 1951 LGPP------------QCKSITLERGP-DGLGFSIVGGYGSPHGD---------LPIYVK 1988
            +G              Q   + + RG  +G GF IV     P            +P  + 
Sbjct: 951  IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010

Query: 1989 TVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
             +     A   G+LK GD+I+AVNG S+   +H + V ++K    TVTL ++
Sbjct: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1062



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 138/679 (20%), Positives = 243/679 (35%), Gaps = 124/679 (18%)

Query: 1008 TINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
            T++I KG    G T++ +  G G  V+ I+      R   +  GD I+ +N+++  ++T+
Sbjct: 643  TVHIVKGPMGFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTH 699

Query: 1068 AQARAML-------------RRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF 1114
             Q   ML             +R  L  P       P E  +    S    S         
Sbjct: 700  NQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTAS 759

Query: 1115 SSYTGRDIPELPEREEGEGEESELQNTA----YSNWNQPRR-------------VELWRE 1157
             S++ + +PE P  E    ++++         +  W Q R              + LWR+
Sbjct: 760  PSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRK 819

Query: 1158 PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLR 1217
             +   G  I+GG   G           I+I H++    A  +G L+ GD ++ VDG  + 
Sbjct: 820  ET-GFGFRILGGNEPGEP---------IYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869

Query: 1218 DASHEQAVEAIRKAGNP----------VVFMVQSIINRPRKSPLPSLLHNLYPKYNFSST 1267
              SH+  V+ +++A             VVF V    N   + P P+  H+       SS 
Sbjct: 870  GKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN---EVPSPASSHH-------SSN 919

Query: 1268 NPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKE 1327
             P               S +E ++ P  S                 Q+S + +S      
Sbjct: 920  QP--------------ASLTEEKRTPQGS-----------------QNSLNTVSSGSGST 948

Query: 1328 DEFGYSWKNIRERYGTLTGELHMIELEKGHS-GLGLSLAGNKDRSR-----------MSV 1375
               G           T+  + + +E+ +G + G G  +  +  R             M  
Sbjct: 949  SGIGSGGGGGSGVVSTVV-QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPH 1007

Query: 1376 FIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDA 1435
             I  I     A + G+L++ D +L +NG  +  +SH +  ++IK A + V +  I   ++
Sbjct: 1008 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1067

Query: 1436 VNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQ--------HLELP 1487
             N   +     +  + +     Q    E   TT         FK  Q         +EL 
Sbjct: 1068 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1127

Query: 1488 KDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFI 1546
            +   G G ++    +    + +  L E G A   G++++GD+IL ++ E        + I
Sbjct: 1128 RGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAI 1187

Query: 1547 SLLKTAKMTVKLTIHAEN---PDSQAVPSAAGAASG-----EKKNSSQSLMVPQSGSPEP 1598
             L+K     V+L +   +   P+        G A+G     E +        P   S  P
Sbjct: 1188 ELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYP 1247

Query: 1599 ESIRNTSRSSTPAIFASDP 1617
              +  +S        A DP
Sbjct: 1248 PDLHKSSPHGEKRAHARDP 1266



 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)

Query: 147  GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
            G GF ++G      GE  I++  I     A  DGRL+  D+++ ++G  +    +HQ  +
Sbjct: 822  GFGFRILG--GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 877

Query: 207  SILQKA--KDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH--------ME 256
             ++Q+A  +  V L + R  +   V    +  PS AS+  + + P               
Sbjct: 878  QLMQQAAKQGHVNLTVRR-KVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN 936

Query: 257  TIELVNDGSGL--GFGIIGGKATGVIVKTILP---------------------------- 286
            ++  V+ GSG   G G  GG  +GV+   + P                            
Sbjct: 937  SLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 996

Query: 287  ------------------GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNR 328
                              G  AD+ G+L  GD IL +    +   S   +  ++++ GN 
Sbjct: 997  TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1056

Query: 329  VKLMIARGAIEERTAPTALG-------ITLSSSPTS--TPELRVDA-----------STQ 368
            V L I  G  +E +  T L        IT + +P+   T E R              + Q
Sbjct: 1057 VTLRIIPG--DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQ 1114

Query: 369  KGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428
              +E + + VEL +  +G G ++ G     +     ++V  + +    E  G+++IGD+I
Sbjct: 1115 ATQEQDFYTVELERGAKGFGFSLRG----GREYNMDLYVLRLAEDGPAERCGKMRIGDEI 1170

Query: 429  IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
            + ++G   +   + +A+E++++ G+ V L L R
Sbjct: 1171 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1203



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 137/631 (21%), Positives = 238/631 (37%), Gaps = 109/631 (17%)

Query: 225  LPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVI--VK 282
            +P    P  +R+PS       H+           +L     G GF ++GG        +K
Sbjct: 451  VPLQGKPFFTRNPSELKGKFIHT-----------KLRKSSRGFGFTVVGGDEPDEFLQIK 499

Query: 283  TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ--CGNRVKLMIARG---- 336
            +++  G A   G++ +GD I+ + DT + G +  QV ++ +    G  V L + RG    
Sbjct: 500  SLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559

Query: 337  --------------AIEER-----------------------------TAPTALGITLSS 353
                          AI ++                               P++     S+
Sbjct: 560  FDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN 619

Query: 354  SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKS 413
            S    P   V  ++    + E   V + K   G G TIA   G       G  VK I  S
Sbjct: 620  SSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGG-----GGQRVKQIVDS 674

Query: 414  SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH--TGQTVLLTLMRRGMKQEAELM 471
                    ++ GD I+ V+  N+Q  T+ Q V++L     G  V L + R G+    +  
Sbjct: 675  PRCR---GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSP 731

Query: 472  SREDV-TKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDA 530
              + +  KD+     N+S    +  +     S + +T +LP     +P   A+  +  D+
Sbjct: 732  KSQPLERKDSQ----NSSQHSVSSHRSLHTASPSHSTQVLPE----FPPAEAQAPDQTDS 783

Query: 531  ---QKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVL 582
               +K +   +    R M  N          F      G       G+      +I  ++
Sbjct: 784  SGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIV 843

Query: 583  PEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE--VTMVCCRRTV--PPT 638
            P G     G+L SGDEL+ V+G  ++G++HQ VV ++++   +  V +   R+ V   P 
Sbjct: 844  PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPK 903

Query: 639  TQSELDS------LDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLA 692
            T++E+ S             LTE+     G    S  T       T    S     + + 
Sbjct: 904  TENEVPSPASSHHSSNQPASLTEEKRTPQGS-QNSLNTVSSGSGSTSGIGSGGGGGSGVV 962

Query: 693  MWEAGIQHIELEKG-SKGLGFSILDYQDPIDPASTV--------IIIRSLVPGGIAEKDG 743
                    +E+ +G ++G GF I+      +  +T           I  ++ G  A++ G
Sbjct: 963  STVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCG 1022

Query: 744  RLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
            +L  GDR++ VN  ++ N S  + V  +K A
Sbjct: 1023 KLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1053



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 120/513 (23%), Positives = 193/513 (37%), Gaps = 117/513 (22%)

Query: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
            ++P      PE  R       P  F  +P+    + G     ++ K   G G ++VGG D
Sbjct: 436  VIPNHPPSNPEPAREVPLQGKP-FFTRNPSE---LKGKFIHTKLRKSSRGFGFTVVGG-D 490

Query: 1649 TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTP--QRVRL 1706
                 + I  +  +G A  DG++  GD I+ VN   +   TH + + + +  P    V L
Sbjct: 491  EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDL 550

Query: 1707 TLYRD-EAPYKEEEVCDTLTIE---LQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADA 1762
             L R    P+  ++   +L      L K+P                     I+  G    
Sbjct: 551  ELCRGYPLPFDPDDPNTSLVTSVAILDKEP---------------------IIVNGQETY 589

Query: 1763 DGRLMQGDQILMVNG-EDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKK 1821
            D       +   VNG +D R ++   VA        S SS  +P    S + S+ +  + 
Sbjct: 590  DSPASHSSKTGKVNGMKDARPSSPADVA--------SNSSHGYPNDTVSLASSIATQPE- 640

Query: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVG 1881
                     L TV + KGP    G +IA   G     V   +      G       L+ G
Sbjct: 641  ---------LITVHIVKGPM-GFGFTIADSPGGGGQRVKQIVDSPRCRG-------LKEG 683

Query: 1882 DRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEMQVVAGGDVSV----------------- 1923
            D IV +   + + +TH Q V++L     GS    +V  G + V                 
Sbjct: 684  DLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQN 743

Query: 1924 -----VTGHQQEPASSSLSFTGLT------------------------------SSSIFQ 1948
                 V+ H+    +S    T +                               S S+++
Sbjct: 744  SSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYE 803

Query: 1949 DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQI 2008
            + L   Q + I L R   G GF I+GG  +  G+ PIY+  +   GAA  DGRL+ GD++
Sbjct: 804  NRLPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PIYIGHIVPLGAADTDGRLRSGDEL 860

Query: 2009 IAVNGQSLEGVTHEEAVAILKRT--KGTVTLMV 2039
            I V+G  + G +H+  V ++++   +G V L V
Sbjct: 861  ICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 893



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 59/243 (24%), Positives = 106/243 (43%), Gaps = 50/243 (20%)

Query: 1726 IELQKKPGKGLGLSIVGK--RNDTGVF-----------VSDIVKGGIADADGRLMQGDQI 1772
            +E+++   +G G  IV    R + G             +  I++G  AD  G+L  GD+I
Sbjct: 971  VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030

Query: 1773 LMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSK------------ 1820
            L VNG  + N +   +  L+K +  +++    P   SS +  L ++ K            
Sbjct: 1031 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQ 1090

Query: 1821 --------------------KNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVP 1860
                                K   A++ Q   TVE+++G     G S+ GG      ++ 
Sbjct: 1091 QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERG-AKGFGFSLRGGREY---NMD 1146

Query: 1861 IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1920
            +++  +   G A +  K+R+GD I+ I G +T+ M H++A+ L+KN    + +  +  GD
Sbjct: 1147 LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL-FLKRGD 1205

Query: 1921 VSV 1923
             SV
Sbjct: 1206 GSV 1208



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 65/264 (24%), Positives = 116/264 (43%), Gaps = 44/264 (16%)

Query: 139  ELLKPPSGGLGFSVVGLRSENRGELGIF-----------VQEIQEGSVAHRDGRLKETDQ 187
            E+ +  + G GF +V   S +R E G             +  I EGS A R G+LK  D+
Sbjct: 972  EIRRGENEGFGFVIVS--SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029

Query: 188  ILAINGQALDQTITHQQAISILQKAKDTVQLVIARG----------SLPQLVSPIVSRSP 237
            ILA+NG ++    +H   ++++++A +TV L I  G          +  ++ +   + +P
Sbjct: 1030 ILAVNGCSITNK-SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1088

Query: 238  SAASTISAHSNPVHWQHME---------------TIELVNDGSGLGFGIIGGKATGV--I 280
            S   T    +     Q  +               T+EL     G GF + GG+   +   
Sbjct: 1089 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1148

Query: 281  VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR--GAI 338
            V  +   G A++ G++  GD IL+I       M   +  ++++  G RV+L + R  G++
Sbjct: 1149 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV 1208

Query: 339  EERTAPTALGITLSSSPTSTPELR 362
             E   P++     ++ P   PE+R
Sbjct: 1209 PEYD-PSSDRHGPATGPQGVPEVR 1231



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 103/451 (22%), Positives = 180/451 (39%), Gaps = 73/451 (16%)

Query: 379 ELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
           +L K+ +G G T+ G  GD+  E   + +KS+        DG+++ GD I++V+ T + G
Sbjct: 474 KLRKSSRGFGFTVVG--GDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529

Query: 439 FTNQQAVEVLRHT--GQTVLLTLMRR-GMKQEAELMSREDVTKDA--DLSPVNASIIKEN 493
            T+ Q V++ +    G +V L L R   +  + +  +   VT  A  D  P+  +  +E 
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNG-QET 588

Query: 494 YEKDEDFLSSTRNTN------------ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKW 541
           Y+      S T   N            +      GYP          D     +++ T+ 
Sbjct: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP---------NDTVSLASSIATQ- 638

Query: 542 QRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLE 601
                   E++  H+ K     G  I+     G   ++ ++ + P      L  GD ++E
Sbjct: 639 -------PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVE 688

Query: 602 VNGITLLGENHQDVVNILKELP--IEVTMVCCRRTVP-PTTQSELDSLDLCDIELTEKPH 658
           VN   +    H  VV++L E P   EVT++  R  +P P    +   L+  D + + +  
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHS 748

Query: 659 VDLGEFIGSSETEDPVLAMTD-----------AGQSTEEVQAPLAMWEAGI--------- 698
           V     + ++        + +              S ++   P  +W             
Sbjct: 749 VSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPD 808

Query: 699 ---QHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
              Q I L +   G GF IL   +P +P    I I  +VP G A+ DGRL  GD L+ V+
Sbjct: 809 YQEQDIFLWRKETGFGFRILGGNEPGEP----IYIGHIVPLGAADTDGRLRSGDELICVD 864

Query: 756 DVNLENSSLEEAVEAL-KGAPSGTVRIGVAK 785
              +   S +  V+ + + A  G V + V +
Sbjct: 865 GTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 895



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 45/264 (17%)

Query: 578 IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI--EVTMVCCRRTV 635
           I+S++ +GP    GK+ +GD ++ VN   +LG  H  VV I + +PI   V +  CR   
Sbjct: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557

Query: 636 PPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETED----------PVLAMTDAGQS-- 683
            P    + ++  +  + + +K  +     +   ET D           V  M DA  S  
Sbjct: 558 LPFDPDDPNTSLVTSVAILDKEPI----IVNGQETYDSPASHSSKTGKVNGMKDARPSSP 613

Query: 684 --------------TEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
                         T  + + +A  +  +  + + KG  G GF+I D      P      
Sbjct: 614 ADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD-----SPGGGGQR 667

Query: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGT-VRIGVAK--- 785
           ++ +V    + +   L  GD ++ VN  N++  +  + V+ L   P G+ V + V +   
Sbjct: 668 VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724

Query: 786 PLPLSPEEGYVSAKEDSFLYPPHS 809
           P+P    +     ++DS     HS
Sbjct: 725 PVPKKSPKSQPLERKDSQNSSQHS 748


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
          Length = 767

 Score =  129 bits (324), Expect = 3e-29
 Identities = 102/344 (29%), Positives = 156/344 (45%), Gaps = 58/344 (16%)

Query: 1730 KKPGKGLGLSIVGKRN------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783
            ++   GLG SI G  +      D  +F++ I+ GG A  DGRL   D IL VN  DVR  
Sbjct: 112  ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 171

Query: 1784 TQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS 1843
            T  A    LK +   +  +                 ++   A ++  ++ ++  KG    
Sbjct: 172  THSAAVEALKEAGSIVRLYVM---------------RRKPPAEKVMEIKLIKGPKG---- 212

Query: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
            LG SIAGGVG+    GD  I++  +   G A +  +L++GD+I+ +     E + H  AV
Sbjct: 213  LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 272

Query: 1902 NLLKNASGSIEMQVV-----------AGGDVSVVTGHQQEPASSSLSFTGL--------T 1942
              LKN    + ++V            A  D++       +   S  S+ G         T
Sbjct: 273  AALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPT 332

Query: 1943 S----SSIFQDDLG----PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKG 1994
            S    S + +D LG    P + + I + RG  GLGF+IVGG         I++  + A G
Sbjct: 333  SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEG----IFISFILAGG 388

Query: 1995 AASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
             A   G L++GDQI++VNG  L   +HE+A   LK    TVT++
Sbjct: 389  PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432



 Score =  123 bits (308), Expect = 2e-27
 Identities = 119/383 (31%), Positives = 167/383 (43%), Gaps = 58/383 (15%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +    S+FI  I P GAA +DGRL++ D +L +N
Sbjct: 105  EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 164

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   +H  A   +K A S V++  +R K                          K  
Sbjct: 165  EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAE----------------------KVM 202

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
            E  +      +  S    V +  +P D              + + +  + E G A  DGR
Sbjct: 203  EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGR 248

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI----HAENPDSQAVPSAAGAAS 1578
            L++GD+ILAV+   +     E  ++ LK     V L +    +A   DS A P    + S
Sbjct: 249  LQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYS 308

Query: 1579 GEKKNS-SQSLMVPQSGSPEPESIRNTS-RSSTPAIFASDPATCPIIPGCETTIEISKGR 1636
                N  S S  +   G+  P ++  TS R  +P   A D      IP     I I +G 
Sbjct: 309  QHLDNEISHSSYL---GTDYPTAMTPTSPRRYSPV--AKDLLGEEDIPREPRRIVIHRGS 363

Query: 1637 TGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINV 1696
            TGLG +IVGG D     I I  +   G A   G L  GDQIL VNG+DLR A+H++A   
Sbjct: 364  TGLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIA 421

Query: 1697 LRQTPQRVRLTLYRDEAPYKEEE 1719
            L+   Q V +      A YK EE
Sbjct: 422  LKNAGQTVTII-----AQYKPEE 439



 Score =  121 bits (304), Expect = 6e-27
 Identities = 102/332 (30%), Positives = 152/332 (45%), Gaps = 61/332 (18%)

Query: 1630 IEISKGRTGLGLSIVGGSDTL-LG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
            I + +G +GLG SI GG+D   +G   +I I ++   GAA +DGRL   D IL VN +D+
Sbjct: 109  ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 168

Query: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743
            R+ TH  A+  L++    VRL + R + P ++      + I+L K P KGLG SI G   
Sbjct: 169  REVTHSAAVEALKEAGSIVRLYVMRRKPPAEK-----VMEIKLIKGP-KGLGFSIAGGVG 222

Query: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK------ 1793
                  D  ++V+ I++GG A  DGRL  GD+IL VN   + +   E   A LK      
Sbjct: 223  NQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVV 282

Query: 1794 --------------------------------VSEGSLSSFTFPLSGSSTSESLESSSKK 1821
                                            +S  S     +P + + TS    S   K
Sbjct: 283  YLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAK 342

Query: 1822 NALASE--IQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
            + L  E   +  R + + +G T  LG +I GG         IFI+ +   G A  + +LR
Sbjct: 343  DLLGEEDIPREPRRIVIHRGST-GLGFNIVGGEDGE----GIFISFILAGGPADLSGELR 397

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSI 1911
             GD+I+++ G      +H QA   LKNA  ++
Sbjct: 398  KGDQILSVNGVDLRNASHEQAAIALKNAGQTV 429



 Score =  120 bits (302), Expect = 1e-26
 Identities = 97/382 (25%), Positives = 165/382 (43%), Gaps = 64/382 (16%)

Query: 256 ETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
           E I L    SGLGF I GG           + +  I+PGG A Q GRL   D IL + + 
Sbjct: 107 EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 166

Query: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
           D+  ++     + L++ G+ V+L + R                                +
Sbjct: 167 DVREVTHSAAVEALKEAGSIVRLYVMR--------------------------------R 194

Query: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
           K    +  +++L K  +GLG +IAG +G++ +   + I+V  I +  A   DGR+QIGD+
Sbjct: 195 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 254

Query: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
           I+AV+   L+   ++ AV  L++T   V L + +      ++  +  D+T        + 
Sbjct: 255 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDIT-------TSY 307

Query: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGI 547
           S   +N      +L +   T + PT    Y  ++ ++   ED  ++   ++   +   G+
Sbjct: 308 SQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH-RGSTGL 366

Query: 548 NYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITL 607
            + IV           G GI         FI  +L  GP   SG+L  GD++L VNG+ L
Sbjct: 367 GFNIV-------GGEDGEGI---------FISFILAGGPADLSGELRKGDQILSVNGVDL 410

Query: 608 LGENHQDVVNILKELPIEVTMV 629
              +H+     LK     VT++
Sbjct: 411 RNASHEQAAIALKNAGQTVTII 432



 Score =  115 bits (289), Expect = 3e-25
 Identities = 81/210 (38%), Positives = 107/210 (50%), Gaps = 36/210 (17%)

Query: 1834 VEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891
            + +++G    LG SIAGG  +P +GD P IFI  + P G AAQ  +LRV D I+ +    
Sbjct: 109  ITLERG-NSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167

Query: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL 1951
               +TH+ AV  LK A   + + V+           ++ PA   +               
Sbjct: 168  VREVTHSAAVEALKEAGSIVRLYVM----------RRKPPAEKVME-------------- 203

Query: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQII 2009
                   I L +GP GLGFSI GG G+ H  GD  IYV  +   GAA +DGRL+ GD+I+
Sbjct: 204  -------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256

Query: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            AVN   LE V HE+AVA LK T   V L V
Sbjct: 257  AVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286



 Score =  107 bits (267), Expect = 1e-22
 Identities = 117/460 (25%), Positives = 187/460 (40%), Gaps = 92/460 (20%)

Query: 36  LKSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHL--SPAVIPTLQNESF 93
           L +VL S LF  +L +    +      +++ S     +    P L  SPA +P   N   
Sbjct: 26  LLTVLHSDLFQALLDILDYYE-----ASLSESQKYRYQDEDTPPLEHSPAHLPNQANSP- 79

Query: 94  LLSPNNGNLEALTGPGIP-HINGKPACDEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSV 152
              P   N + L  PG    +NG     E++++               L+  + GLGFS+
Sbjct: 80  ---PVIVNTDTLEAPGYELQVNGTEGEMEYEEIT--------------LERGNSGLGFSI 122

Query: 153 VGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQ 210
            G         +  IF+ +I  G  A +DGRL+  D IL +N   + + +TH  A+  L+
Sbjct: 123 AGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE-VTHSAAVEALK 181

Query: 211 KAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFG 270
           +A   V+L + R            R P A   +              I+L+    GLGF 
Sbjct: 182 EAGSIVRLYVMR------------RKPPAEKVME-------------IKLIKGPKGLGFS 216

Query: 271 IIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323
           I GG           + V  I+ GG A + GRL  GD IL +    L  +  E     L+
Sbjct: 217 IAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALK 276

Query: 324 QCGNRVKLMIARGA---IEERTAPTALGITLSS--------------------SPTSTPE 360
              + V L +A+ +   + +  AP  +  + S                     +PTS   
Sbjct: 277 NTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRR 336

Query: 361 LRVDASTQKGEES---ETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVE 417
               A    GEE    E   + + +   GLG  I G  G+   +  GIF+  I      +
Sbjct: 337 YSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG--GE---DGEGIFISFILAGGPAD 391

Query: 418 HDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL 457
             G ++ GDQI++V+G +L+  +++QA   L++ GQTV +
Sbjct: 392 LSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 95/307 (30%), Positives = 138/307 (44%), Gaps = 79/307 (25%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DGR+ IGD IL++N 
Sbjct: 204  IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 260

Query: 1060 ESTISVTNAQARAMLRR------------------HSLIGPDIKITYVPAEHLEEFKISL 1101
                 V +  A A L+                    S   PDI  +Y  ++HL+  +IS 
Sbjct: 261  VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSY--SQHLDN-EIS- 316

Query: 1102 GQQSGRVMALDIFSSYTGRDIPEL----------PEREEGEGEESELQNTAYSNWNQPRR 1151
                         SSY G D P            P  ++  GEE   +        +PRR
Sbjct: 317  ------------HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR--------EPRR 356

Query: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
            + + R  S  LG +IVGG        +GE   GIFI  +L   PA  +G L+ GD+I+ V
Sbjct: 357  IVIHRG-STGLGFNIVGGE-------DGE---GIFISFILAGGPADLSGELRKGDQILSV 405

Query: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPF 1270
            +G+DLR+ASHEQA  A++ AG  V  + Q    +P + S   + +H+L  +   SS    
Sbjct: 406  NGVDLRNASHEQAAIALKNAGQTVTIIAQ---YKPEEYSRFEAKIHDLREQLMNSSLGSG 462

Query: 1271 ADSLQIN 1277
              SL+ N
Sbjct: 463  TASLRSN 469



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 44/233 (18%)

Query: 139 ELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196
           +L+K P G LGFS+ G        G+  I+V +I EG  AH+DGRL+  D+ILA+N   L
Sbjct: 205 KLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 263

Query: 197 DQTITHQQAISILQKAKDTVQLVIARGS-------------------------------- 224
           +  + H+ A++ L+   D V L +A+ S                                
Sbjct: 264 ED-VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 322

Query: 225 --LPQLVSPIVSR--SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGK-ATGV 279
              P  ++P   R  SP A   +     P   +    I +    +GLGF I+GG+   G+
Sbjct: 323 TDYPTAMTPTSPRRYSPVAKDLLGEEDIP---REPRRIVIHRGSTGLGFNIVGGEDGEGI 379

Query: 280 IVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLM 332
            +  IL GG AD  G L  GD IL +   DL   S EQ A  L+  G  V ++
Sbjct: 380 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 432



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 110/451 (24%), Positives = 181/451 (40%), Gaps = 78/451 (17%)

Query: 640  QSELDSLDLCDIELTEK-----------PHVDLGEFIGSSETEDPVLAMTDAGQSTE-EV 687
            Q+ LD LD  +  L+E            P       + +     PV+  TD  ++   E+
Sbjct: 36   QALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYEL 95

Query: 688  QAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIRSLVPGGIAEKDGRLL 746
            Q      E   + I LE+G+ GLGFSI    D P       I I  ++PGG A +DGRL 
Sbjct: 96   QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155

Query: 747  PGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYP 806
              D ++FVN+V++   +   AVEALK A S  VR+ V +  P  P E  +  K       
Sbjct: 156  VNDSILFVNEVDVREVTHSAAVEALKEAGS-IVRLYVMRRKP--PAEKVMEIK------- 205

Query: 807  PHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSS 866
                                + G             + + P ++SIY T+   +   G++
Sbjct: 206  -------------------LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTK---IIEGGAA 243

Query: 867  CGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMG- 924
              DG L  G        K +  NS        + LE++  ++ +         V + +  
Sbjct: 244  HKDGRLQIGD-------KILAVNS--------VGLEDVMHEDAVAALKNTYDVVYLKVAK 288

Query: 925  PASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLE 984
            P++ +  + Y P + I   Y           HL +E+  S+ L +  P +    S     
Sbjct: 289  PSNAYLSDSYAPPD-ITTSY---------SQHLDNEISHSSYLGTDYPTAMTPTSPRRYS 338

Query: 985  QSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISR 1044
              +     E    +++ +E   R I I +G++ LG  +   +DG G+ +  I+ GG    
Sbjct: 339  PVAKDLLGE----EDIPRE--PRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADL 392

Query: 1045 DGRIAIGDCILSINEESTISVTNAQARAMLR 1075
             G +  GD ILS+N     + ++ QA   L+
Sbjct: 393  SGELRKGDQILSVNGVDLRNASHEQAAIALK 423



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 74/268 (27%), Positives = 109/268 (40%), Gaps = 21/268 (7%)

Query: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
           GLG S+   VG+         ++  ++  G     G+L  GD++L VN + L    H+D 
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVL 675
           V  LK     V +    +   P+     DS    DI  +   H+D      S    D   
Sbjct: 272 VAALKNTYDVVYL----KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPT 327

Query: 676 AMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
           AMT          A   + E  I    + I + +GS GLGF+I+  +D        I I 
Sbjct: 328 AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFIS 382

Query: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
            ++ GG A+  G L  GD+++ VN V+L N+S E+A  ALK A      I   KP   S 
Sbjct: 383 FILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSR 442

Query: 792 EEGYVSAKEDSFLYPPHSCEEAGLADKP 819
            E  +    +  +        A L   P
Sbjct: 443 FEAKIHDLREQLMNSSLGSGTASLRSNP 470



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 42/91 (46%), Positives = 54/91 (59%), Gaps = 2/91 (2%)

Query: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQII 2009
            G  + + ITLERG  GLGFSI GG  +PH GD P I++  +   GAA++DGRL+  D I+
Sbjct: 102  GEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 161

Query: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
             VN   +  VTH  AV  LK     V L V+
Sbjct: 162  FVNEVDVREVTHSAAVEALKEAGSIVRLYVM 192



 Score = 60.5 bits (145), Expect = 2e-08
 Identities = 68/252 (26%), Positives = 95/252 (37%), Gaps = 66/252 (26%)

Query: 543 RIMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLF 594
           ++ G   E+    ++    NSGLG S+   T   H       FI  ++P G     G+L 
Sbjct: 96  QVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLR 155

Query: 595 SGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELT 654
             D +L VN + +    H   V  LKE    V +   RR  PP  +       + +I+L 
Sbjct: 156 VNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-PPAEK-------VMEIKLI 207

Query: 655 EKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSI 714
           + P   LG  I                               G QHI             
Sbjct: 208 KGPK-GLGFSIAGG---------------------------VGNQHI------------- 226

Query: 715 LDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
                   P    I +  ++ GG A KDGRL  GD+++ VN V LE+   E+AV ALK  
Sbjct: 227 --------PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT 278

Query: 775 PSGTVRIGVAKP 786
               V + VAKP
Sbjct: 279 -YDVVYLKVAKP 289



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 37/119 (31%), Positives = 62/119 (52%), Gaps = 10/119 (8%)

Query: 349 ITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAG-----YIGDKKLEPS 403
           + +++     P   +  +  +GE  E  ++ L +   GLG +IAG     +IGD   +PS
Sbjct: 81  VIVNTDTLEAPGYELQVNGTEGE-MEYEEITLERGNSGLGFSIAGGTDNPHIGD---DPS 136

Query: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
            IF+  I    A   DGR+++ D I+ V+  +++  T+  AVE L+  G  V L +MRR
Sbjct: 137 -IFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 194



 Score = 52.0 bits (123), Expect = 6e-06
 Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 19/180 (10%)

Query: 931  INDYTPANAIE-QQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLA 989
            I DY  A+  E Q+Y  ++       H P+ + + A  P V+ ++            +L 
Sbjct: 41   ILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNT-----------DTLE 89

Query: 990  CNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAIS 1043
                 + +     E     I + +GNS LG +++   D         + +  II GGA +
Sbjct: 90   APGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAA 149

Query: 1044 RDGRIAIGDCILSINEESTISVTNAQA-RAMLRRHSLIGPDIKITYVPAEHLEEFKISLG 1102
            +DGR+ + D IL +NE     VT++ A  A+    S++   +     PAE + E K+  G
Sbjct: 150  QDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKG 209



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 4/77 (5%)

Query: 1159 SKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRD 1218
            +  LG SI GG      + +      IFI  ++    A ++G L+  D I+ V+ +D+R+
Sbjct: 115  NSGLGFSIAGGTD-NPHIGDDP---SIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 170

Query: 1219 ASHEQAVEAIRKAGNPV 1235
             +H  AVEA+++AG+ V
Sbjct: 171  VTHSAAVEALKEAGSIV 187



 Score = 39.3 bits (90), Expect = 0.040
 Identities = 33/138 (23%), Positives = 58/138 (42%), Gaps = 16/138 (11%)

Query: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFK----------NVQHLELPKDQGGLGIAIS 1498
            PL  +  +L N+   P V  +   ++   ++            + + L +   GLG +I+
Sbjct: 64   PLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIA 123

Query: 1499 --EEDTLSG----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA 1552
               ++   G    + I  +   G AA DGRL+V D IL V++  V        +  LK A
Sbjct: 124  GGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEA 183

Query: 1553 KMTVKLTIHAENPDSQAV 1570
               V+L +    P ++ V
Sbjct: 184  GSIVRLYVMRRKPPAEKV 201


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
            sapiens]
          Length = 721

 Score =  129 bits (324), Expect = 3e-29
 Identities = 102/344 (29%), Positives = 156/344 (45%), Gaps = 58/344 (16%)

Query: 1730 KKPGKGLGLSIVGKRN------DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783
            ++   GLG SI G  +      D  +F++ I+ GG A  DGRL   D IL VN  DVR  
Sbjct: 66   ERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREV 125

Query: 1784 TQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS 1843
            T  A    LK +   +  +                 ++   A ++  ++ ++  KG    
Sbjct: 126  THSAAVEALKEAGSIVRLYVM---------------RRKPPAEKVMEIKLIKGPKG---- 166

Query: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
            LG SIAGGVG+    GD  I++  +   G A +  +L++GD+I+ +     E + H  AV
Sbjct: 167  LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAV 226

Query: 1902 NLLKNASGSIEMQVV-----------AGGDVSVVTGHQQEPASSSLSFTGL--------T 1942
              LKN    + ++V            A  D++       +   S  S+ G         T
Sbjct: 227  AALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPT 286

Query: 1943 S----SSIFQDDLG----PPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKG 1994
            S    S + +D LG    P + + I + RG  GLGF+IVGG         I++  + A G
Sbjct: 287  SPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEG----IFISFILAGG 342

Query: 1995 AASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
             A   G L++GDQI++VNG  L   +HE+A   LK    TVT++
Sbjct: 343  PADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386



 Score =  123 bits (309), Expect = 2e-27
 Identities = 109/361 (30%), Positives = 163/361 (45%), Gaps = 67/361 (18%)

Query: 1607 SSTPAIFASDPATCP-IIPGCETTIE-----ISKGRTGLGLSIVGGSDTL-LG---AIII 1656
            +S P I  +D    P  + G E  +E     + +G +GLG SI GG+D   +G   +I I
Sbjct: 34   NSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFI 93

Query: 1657 HEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1716
             ++   GAA +DGRL   D IL VN +D+R+ TH  A+  L++    VRL + R + P +
Sbjct: 94   TKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAE 153

Query: 1717 EEEVCDTLTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGD 1770
            +      + I+L K P KGLG SI G         D  ++V+ I++GG A  DGRL  GD
Sbjct: 154  K-----VMEIKLIKGP-KGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD 207

Query: 1771 QILMVNGEDVRNATQEAVAALLK------------------------------------- 1793
            +IL VN   + +   E   A LK                                     
Sbjct: 208  KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDN 267

Query: 1794 -VSEGSLSSFTFPLSGSSTSESLESSSKKNALASE--IQGLRTVEMKKGPTDSLGISIAG 1850
             +S  S     +P + + TS    S   K+ L  E   +  R + + +G T  LG +I G
Sbjct: 268  EISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGST-GLGFNIVG 326

Query: 1851 GVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGS 1910
            G         IFI+ +   G A  + +LR GD+I+++ G      +H QA   LKNA  +
Sbjct: 327  GEDGE----GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQT 382

Query: 1911 I 1911
            +
Sbjct: 383  V 383



 Score =  123 bits (308), Expect = 2e-27
 Identities = 119/383 (31%), Positives = 167/383 (43%), Gaps = 58/383 (15%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +    S+FI  I P GAA +DGRL++ D +L +N
Sbjct: 59   EYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVN 118

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   +H  A   +K A S V++  +R K                          K  
Sbjct: 119  EVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAE----------------------KVM 156

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
            E  +      +  S    V +  +P D              + + +  + E G A  DGR
Sbjct: 157  EIKLIKGPKGLGFSIAGGVGNQHIPGD--------------NSIYVTKIIEGGAAHKDGR 202

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI----HAENPDSQAVPSAAGAAS 1578
            L++GD+ILAV+   +     E  ++ LK     V L +    +A   DS A P    + S
Sbjct: 203  LQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYS 262

Query: 1579 GEKKNS-SQSLMVPQSGSPEPESIRNTS-RSSTPAIFASDPATCPIIPGCETTIEISKGR 1636
                N  S S  +   G+  P ++  TS R  +P   A D      IP     I I +G 
Sbjct: 263  QHLDNEISHSSYL---GTDYPTAMTPTSPRRYSPV--AKDLLGEEDIPREPRRIVIHRGS 317

Query: 1637 TGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINV 1696
            TGLG +IVGG D     I I  +   G A   G L  GDQIL VNG+DLR A+H++A   
Sbjct: 318  TGLGFNIVGGEDG--EGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIA 375

Query: 1697 LRQTPQRVRLTLYRDEAPYKEEE 1719
            L+   Q V +      A YK EE
Sbjct: 376  LKNAGQTVTII-----AQYKPEE 393



 Score =  120 bits (302), Expect = 1e-26
 Identities = 97/382 (25%), Positives = 165/382 (43%), Gaps = 64/382 (16%)

Query: 256 ETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
           E I L    SGLGF I GG           + +  I+PGG A Q GRL   D IL + + 
Sbjct: 61  EEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEV 120

Query: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
           D+  ++     + L++ G+ V+L + R                                +
Sbjct: 121 DVREVTHSAAVEALKEAGSIVRLYVMR--------------------------------R 148

Query: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
           K    +  +++L K  +GLG +IAG +G++ +   + I+V  I +  A   DGR+QIGD+
Sbjct: 149 KPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDK 208

Query: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
           I+AV+   L+   ++ AV  L++T   V L + +      ++  +  D+T        + 
Sbjct: 209 ILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDIT-------TSY 261

Query: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGI 547
           S   +N      +L +   T + PT    Y  ++ ++   ED  ++   ++   +   G+
Sbjct: 262 SQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIH-RGSTGL 320

Query: 548 NYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITL 607
            + IV           G GI         FI  +L  GP   SG+L  GD++L VNG+ L
Sbjct: 321 GFNIV-------GGEDGEGI---------FISFILAGGPADLSGELRKGDQILSVNGVDL 364

Query: 608 LGENHQDVVNILKELPIEVTMV 629
              +H+     LK     VT++
Sbjct: 365 RNASHEQAAIALKNAGQTVTII 386



 Score =  118 bits (296), Expect = 5e-26
 Identities = 85/232 (36%), Positives = 117/232 (50%), Gaps = 37/232 (15%)

Query: 1812 SESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPT 1869
            +++LE+    N    E++    + +++G    LG SIAGG  +P +GD P IFI  + P 
Sbjct: 42   TDTLEAPGYVNGTEGEME-YEEITLERG-NSGLGFSIAGGTDNPHIGDDPSIFITKIIPG 99

Query: 1870 GVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQ 1929
            G AAQ  +LRV D I+ +       +TH+ AV  LK A   + + V+           ++
Sbjct: 100  GAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM----------RRK 149

Query: 1930 EPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYV 1987
             PA   +                      I L +GP GLGFSI GG G+ H  GD  IYV
Sbjct: 150  PPAEKVME---------------------IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYV 188

Query: 1988 KTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
              +   GAA +DGRL+ GD+I+AVN   LE V HE+AVA LK T   V L V
Sbjct: 189  TKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240



 Score =  106 bits (264), Expect = 3e-22
 Identities = 107/412 (25%), Positives = 170/412 (41%), Gaps = 86/412 (20%)

Query: 81  SPAVIPTLQNESFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFEL 140
           SPA +P   N      P   N + L  PG  ++NG     E++++               
Sbjct: 25  SPAHLPNQANSP----PVIVNTDTLEAPG--YVNGTEGEMEYEEIT-------------- 64

Query: 141 LKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
           L+  + GLGFS+ G         +  IF+ +I  G  A +DGRL+  D IL +N   + +
Sbjct: 65  LERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 124

Query: 199 TITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETI 258
            +TH  A+  L++A   V+L + R            R P A   +              I
Sbjct: 125 -VTHSAAVEALKEAGSIVRLYVMR------------RKPPAEKVME-------------I 158

Query: 259 ELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
           +L+    GLGF I GG           + V  I+ GG A + GRL  GD IL +    L 
Sbjct: 159 KLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLE 218

Query: 312 GMSSEQVAQVLRQCGNRVKLMIARGA---IEERTAPTALGITLSS--------------- 353
            +  E     L+   + V L +A+ +   + +  AP  +  + S                
Sbjct: 219 DVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTD 278

Query: 354 -----SPTSTPELRVDASTQKGEES---ETFDVELTKNVQGLGITIAGYIGDKKLEPSGI 405
                +PTS       A    GEE    E   + + +   GLG  I G  G+   +  GI
Sbjct: 279 YPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVG--GE---DGEGI 333

Query: 406 FVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL 457
           F+  I      +  G ++ GDQI++V+G +L+  +++QA   L++ GQTV +
Sbjct: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 95/307 (30%), Positives = 138/307 (44%), Gaps = 79/307 (25%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DGR+ IGD IL++N 
Sbjct: 158  IKLIKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNS 214

Query: 1060 ESTISVTNAQARAMLRR------------------HSLIGPDIKITYVPAEHLEEFKISL 1101
                 V +  A A L+                    S   PDI  +Y  ++HL+  +IS 
Sbjct: 215  VGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSY--SQHLDN-EIS- 270

Query: 1102 GQQSGRVMALDIFSSYTGRDIPEL----------PEREEGEGEESELQNTAYSNWNQPRR 1151
                         SSY G D P            P  ++  GEE   +        +PRR
Sbjct: 271  ------------HSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPR--------EPRR 310

Query: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
            + + R  S  LG +IVGG        +GE   GIFI  +L   PA  +G L+ GD+I+ V
Sbjct: 311  IVIHRG-STGLGFNIVGGE-------DGE---GIFISFILAGGPADLSGELRKGDQILSV 359

Query: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPF 1270
            +G+DLR+ASHEQA  A++ AG  V  + Q    +P + S   + +H+L  +   SS    
Sbjct: 360  NGVDLRNASHEQAAIALKNAGQTVTIIAQ---YKPEEYSRFEAKIHDLREQLMNSSLGSG 416

Query: 1271 ADSLQIN 1277
              SL+ N
Sbjct: 417  TASLRSN 423



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 72/233 (30%), Positives = 104/233 (44%), Gaps = 44/233 (18%)

Query: 139 ELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196
           +L+K P G LGFS+ G        G+  I+V +I EG  AH+DGRL+  D+ILA+N   L
Sbjct: 159 KLIKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGL 217

Query: 197 DQTITHQQAISILQKAKDTVQLVIARGS-------------------------------- 224
           +  + H+ A++ L+   D V L +A+ S                                
Sbjct: 218 ED-VMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLG 276

Query: 225 --LPQLVSPIVSR--SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGK-ATGV 279
              P  ++P   R  SP A   +     P   +    I +    +GLGF I+GG+   G+
Sbjct: 277 TDYPTAMTPTSPRRYSPVAKDLLGEEDIP---REPRRIVIHRGSTGLGFNIVGGEDGEGI 333

Query: 280 IVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLM 332
            +  IL GG AD  G L  GD IL +   DL   S EQ A  L+  G  V ++
Sbjct: 334 FISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTII 386



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 74/268 (27%), Positives = 109/268 (40%), Gaps = 21/268 (7%)

Query: 564 GLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDV 615
           GLG S+   VG+         ++  ++  G     G+L  GD++L VN + L    H+D 
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225

Query: 616 VNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVL 675
           V  LK     V +    +   P+     DS    DI  +   H+D      S    D   
Sbjct: 226 VAALKNTYDVVYL----KVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPT 281

Query: 676 AMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGSKGLGFSILDYQDPIDPASTVIIIR 731
           AMT          A   + E  I    + I + +GS GLGF+I+  +D        I I 
Sbjct: 282 AMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGED-----GEGIFIS 336

Query: 732 SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
            ++ GG A+  G L  GD+++ VN V+L N+S E+A  ALK A      I   KP   S 
Sbjct: 337 FILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSR 396

Query: 792 EEGYVSAKEDSFLYPPHSCEEAGLADKP 819
            E  +    +  +        A L   P
Sbjct: 397 FEAKIHDLREQLMNSSLGSGTASLRSNP 424



 Score = 75.9 bits (185), Expect = 4e-13
 Identities = 101/406 (24%), Positives = 166/406 (40%), Gaps = 68/406 (16%)

Query: 673  PVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIR 731
            PV+  TD  ++   V       E   + I LE+G+ GLGFSI    D P       I I 
Sbjct: 37   PVIVNTDTLEAPGYVNGTEGEME--YEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFIT 94

Query: 732  SLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSP 791
             ++PGG A +DGRL   D ++FVN+V++   +   AVEALK A S  VR+ V +  P  P
Sbjct: 95   KIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGS-IVRLYVMRRKP--P 151

Query: 792  EEGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVGTNDADLVDESTFESPYSPENDS 851
             E  +  K                           + G             + + P ++S
Sbjct: 152  AEKVMEIK--------------------------LIKGPKGLGFSIAGGVGNQHIPGDNS 185

Query: 852  IYSTQASILSLHGSSCGDG-LNYGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQ 910
            IY T+   +   G++  DG L  G        K +  NS        + LE++  ++ + 
Sbjct: 186  IYVTK---IIEGGAAHKDGRLQIGD-------KILAVNS--------VGLEDVMHEDAVA 227

Query: 911  RQDENTPSVDISMG-PASGFTINDYTPANAIEQQYECENTIVWTESHLPSEVISSAELPS 969
                    V + +  P++ +  + Y P + I   Y           HL +E+  S+ L +
Sbjct: 228  ALKNTYDVVYLKVAKPSNAYLSDSYAPPD-ITTSY---------SQHLDNEISHSSYLGT 277

Query: 970  VLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGL 1029
              P +    S       +     E    +++ +E   R I I +G++ LG  +   +DG 
Sbjct: 278  DYPTAMTPTSPRRYSPVAKDLLGE----EDIPRE--PRRIVIHRGSTGLGFNIVGGEDGE 331

Query: 1030 GMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
            G+ +  I+ GG     G +  GD ILS+N     + ++ QA   L+
Sbjct: 332  GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 377



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 42/91 (46%), Positives = 54/91 (59%), Gaps = 2/91 (2%)

Query: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQII 2009
            G  + + ITLERG  GLGFSI GG  +PH GD P I++  +   GAA++DGRL+  D I+
Sbjct: 56   GEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSIL 115

Query: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
             VN   +  VTH  AV  LK     V L V+
Sbjct: 116  FVNEVDVREVTHSAAVEALKEAGSIVRLYVM 146



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 68/251 (27%), Positives = 94/251 (37%), Gaps = 66/251 (26%)

Query: 544 IMGINYEIVVAHVSKFSENSGLGISLEA-TVGHH-------FIRSVLPEGPVGHSGKLFS 595
           + G   E+    ++    NSGLG S+   T   H       FI  ++P G     G+L  
Sbjct: 51  VNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRV 110

Query: 596 GDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTE 655
            D +L VN + +    H   V  LKE    V +   RR  PP  +       + +I+L +
Sbjct: 111 NDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRK-PPAEK-------VMEIKLIK 162

Query: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
            P   LG  I                               G QHI              
Sbjct: 163 GPK-GLGFSIAGG---------------------------VGNQHI-------------- 180

Query: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAP 775
                  P    I +  ++ GG A KDGRL  GD+++ VN V LE+   E+AV ALK   
Sbjct: 181 -------PGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNT- 232

Query: 776 SGTVRIGVAKP 786
              V + VAKP
Sbjct: 233 YDVVYLKVAKP 243



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 35/96 (36%), Positives = 53/96 (55%), Gaps = 9/96 (9%)

Query: 372 ESETFDVELTKNVQGLGITIAG-----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
           E E  ++ L +   GLG +IAG     +IGD   +PS IF+  I    A   DGR+++ D
Sbjct: 57  EMEYEEITLERGNSGLGFSIAGGTDNPHIGD---DPS-IFITKIIPGGAAAQDGRLRVND 112

Query: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
            I+ V+  +++  T+  AVE L+  G  V L +MRR
Sbjct: 113 SILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRR 148



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 31/101 (30%), Positives = 51/101 (50%), Gaps = 7/101 (6%)

Query: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++   D         + +  II GGA ++DGR+ + D IL +NE   
Sbjct: 63   ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDV 122

Query: 1063 ISVTNAQA-RAMLRRHSLIGPDIKITYVPAEHLEEFKISLG 1102
              VT++ A  A+    S++   +     PAE + E K+  G
Sbjct: 123  REVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKG 163



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 4/77 (5%)

Query: 1159 SKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRD 1218
            +  LG SI GG      + +      IFI  ++    A ++G L+  D I+ V+ +D+R+
Sbjct: 69   NSGLGFSIAGGTD-NPHIGDDP---SIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVRE 124

Query: 1219 ASHEQAVEAIRKAGNPV 1235
             +H  AVEA+++AG+ V
Sbjct: 125  VTHSAAVEALKEAGSIV 141



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 34/135 (25%), Positives = 58/135 (42%), Gaps = 13/135 (9%)

Query: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFKN-------VQHLELPKDQGGLGIAIS--E 1499
            PL  +  +L N+   P V  +   ++   + N        + + L +   GLG +I+   
Sbjct: 21   PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGT 80

Query: 1500 EDTLSG----VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT 1555
            ++   G    + I  +   G AA DGRL+V D IL V++  V        +  LK A   
Sbjct: 81   DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSI 140

Query: 1556 VKLTIHAENPDSQAV 1570
            V+L +    P ++ V
Sbjct: 141  VRLYVMRRKPPAEKV 155


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score =  127 bits (319), Expect = 1e-28
 Identities = 192/865 (22%), Positives = 345/865 (39%), Gaps = 128/865 (14%)

Query: 941  EQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNV 1000
            +QQ + + T  WTE H       SA +P V+P+      E   E   +    +    +N 
Sbjct: 414  QQQQQQQQTEEWTEDH-------SALVPPVIPNHPPSNPEPARE---VPLQGKPFFTRNP 463

Query: 1001 S--KESFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSI 1057
            S  K  F  T  + K +   G TV    +    + ++S++  G  + DG++  GD I+S+
Sbjct: 464  SELKGKFIHT-KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522

Query: 1058 NEESTISVTNAQARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSG 1106
            N+   +  T+AQ   + +    IG  + +              P   L      L ++  
Sbjct: 523  NDTCVLGHTHAQVVKIFQSIP-IGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPI 581

Query: 1107 RVMALDIF------SSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSK 1160
             V   + +      SS TG+       R     + +   +  Y N        +  +P  
Sbjct: 582  IVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPEL 641

Query: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
                 + G  G G  +++     G  +K ++ DSP  +   LK GD IVEV+  +++  +
Sbjct: 642  ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALT 698

Query: 1221 HEQAVEAIRKA--GNPVVFMVQ-SIINRPRKSPLPSLL----------HNLYPKYNFSST 1267
            H Q V+ + +   G+ V  +VQ   +  P+KSP    L          H++    +  + 
Sbjct: 699  HNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA 758

Query: 1268 NPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDH-----TQSSASKISQ 1322
            +P + S Q+  +  P+++++  +        P P   +A+  S +     + S AS +S+
Sbjct: 759  SP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSK 817

Query: 1323 DVDKEDEFGYSWKNIRERYGTLTGELHM-------IELEKGHSGLGLSLAGNKDRSRMSV 1375
                        +  RE   T  GE  +       I L +  +G G  + G  +     +
Sbjct: 818  G-----------EREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGE-PI 865

Query: 1376 FIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDA 1435
            +I  I P GAA  DGRL+  DEL+ ++G  + G+SHQ    +++ A  +  +     +  
Sbjct: 866  YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 925

Query: 1436 VNQMAVCPGNAVEPLPSNSENLQNKE---TEPTVTTSDAAVDLSSFKNVQHLELPKDQGG 1492
            V   AV       P P++S +  N+    TE   T   +   L++  +          GG
Sbjct: 926  V--FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGG 983

Query: 1493 LG---------------IAISEEDTLSGVIIKSLT-----------------------EH 1514
             G               I   E +    VI+ S++                       E 
Sbjct: 984  GGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEG 1043

Query: 1515 GVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAA 1574
              A   G+LKVGD+ILAV+   +        ++L+K A  TV L I         +P   
Sbjct: 1044 SPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI---------IPGDE 1094

Query: 1575 GAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCET--TIEI 1632
             + +    N+ +   +  + +P  +  + T  ++ P   +      P     +   T+E+
Sbjct: 1095 SSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL 1154

Query: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
             +G  G G S+ GG +  +   ++  + E+G A + G++  GD+ILE+NG   +   H  
Sbjct: 1155 ERGAKGFGFSLRGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1213

Query: 1693 AINVLRQTPQRVRLTLYRDEAPYKE 1717
            AI +++   +RVRL L R +    E
Sbjct: 1214 AIELIKNGGRRVRLFLKRGDGSVPE 1238



 Score =  100 bits (249), Expect = 1e-20
 Identities = 89/384 (23%), Positives = 154/384 (40%), Gaps = 83/384 (21%)

Query: 1735 GLGLSIVGKRNDTG--VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 1792
            G G  I+G  N+ G  +++  IV  G AD DGRL  GD+++ V+G  V   + + V  L+
Sbjct: 850  GFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLM 908

Query: 1793 ------------------------------------------------KVSEGSLSSFTF 1804
                                                            +  +GS +S   
Sbjct: 909  QQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNT 968

Query: 1805 PLSGSSTSESLESSSKKNA-LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPI-- 1861
              SGS ++  + S     + + S +     VE+++G  +  G  I   V  P        
Sbjct: 969  VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGN 1028

Query: 1862 -FIAMMHPTG------VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQ 1914
              +AM H  G       A +  KL+VGDRI+ + G S    +H+  VNL+K A  ++ ++
Sbjct: 1029 ACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLR 1088

Query: 1915 VVAGGDVS-------------VVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCK---- 1957
            ++ G + S             + T H      +  +          Q +   PQ      
Sbjct: 1089 IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD 1148

Query: 1958 --SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQS 2015
              ++ LERG  G GFS+ GG      ++ +YV  +   G A   G+++ GD+I+ +NG++
Sbjct: 1149 FYTVELERGAKGFGFSLRGG---REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGET 1205

Query: 2016 LEGVTHEEAVAILKRTKGTVTLMV 2039
             + + H  A+ ++K     V L +
Sbjct: 1206 TKNMKHSRAIELIKNGGRRVRLFL 1229



 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 152/668 (22%), Positives = 274/668 (41%), Gaps = 99/668 (14%)

Query: 125  LIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKE 184
            L  ++A    +    ++K P G  GF++    +++ G  G  V++I +     R   LKE
Sbjct: 631  LASSIATQPELITVHIVKGPMG-FGFTI----ADSPGGGGQRVKQIVDSP---RCRGLKE 682

Query: 185  TDQILAINGQALDQTITHQQAISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAAST 242
             D I+ +N + + Q +TH Q + +L +      V L++ RG L     P+  +SP     
Sbjct: 683  GDLIVEVNKKNV-QALTHNQVVDMLVECPKGSEVTLLVQRGGL-----PVPKKSPK---- 732

Query: 243  ISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHI 302
                S P+  +  +     +  S           +  ++    P                
Sbjct: 733  ----SQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPD--------- 779

Query: 303  LKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELR 362
                 TD +G       ++  Q         +R   E R    +    LS         R
Sbjct: 780  ----QTDSSGQKKPDPFKIWAQ---------SRSMYENRPMSPSPASGLSKGERE----R 822

Query: 363  VDASTQKGE----ESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEH 418
               ST  GE    + +  D+ L +   G G  I G  G++  EP  I++  I    A + 
Sbjct: 823  EINSTNFGECPIPDYQEQDIFLWRKETGFGFRILG--GNEPGEP--IYIGHIVPLGAADT 878

Query: 419  DGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT--VLLTLMRRGM----KQEAELMS 472
            DGR++ GD++I VDGT + G ++Q  V++++   +   V LT+ R+ +    K E E+ S
Sbjct: 879  DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPS 938

Query: 473  REDVTKDADLSPVNASIIKENYEKDEDFL----SSTRNTNILPTEEEGYPLLSAEIEEIE 528
                   ++  P + +  K   +  ++ L    S + +T+ + +   G   + + + +  
Sbjct: 939  PASSHHSSN-QPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPY 997

Query: 529  DAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVG 588
            D + +            G  + ++V+ VS+    +  G +  A    H I  ++   P  
Sbjct: 998  DVEIRRG-------ENEGFGF-VIVSSVSRPEAGTTFGNACVAMP--HKIGRIIEGSPAD 1047

Query: 589  HSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL-- 646
              GKL  GD +L VNG ++  ++H D+VN++KE    VT+    R +P    S    L  
Sbjct: 1048 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL----RIIPGDESSNATLLTN 1103

Query: 647  --DLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELE 704
               +  I  T  P        G+ ET +         +S  E +AP A  E     +ELE
Sbjct: 1104 AEKIATITTTHTPSQQ-----GTQETRN---TTKPKQESQFEFKAPQATQEQDFYTVELE 1155

Query: 705  KGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSL 764
            +G+KG GFS+   ++     +  + +  L   G AE+ G++  GD ++ +N    +N   
Sbjct: 1156 RGAKGFGFSLRGGRE----YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211

Query: 765  EEAVEALK 772
              A+E +K
Sbjct: 1212 SRAIELIK 1219



 Score = 95.5 bits (236), Expect = 5e-19
 Identities = 109/469 (23%), Positives = 190/469 (40%), Gaps = 91/469 (19%)

Query: 1006 ERTINIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
            E+ I + +  +  G  +   N+ G  + +  I+  GA   DGR+  GD ++ ++    I 
Sbjct: 839  EQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIG 898

Query: 1065 -----VTNAQARAMLRRHSLIGPDIKITYV--------------------PAEHLEEFKI 1099
                 V     +A  + H  +    K+ +                     PA   EE + 
Sbjct: 899  KSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRT 958

Query: 1100 SLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPS 1159
              G Q+    +L+  SS +G           G G      +   S   QP  VE+ R  +
Sbjct: 959  PQGSQN----SLNTVSSGSGST--------SGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006

Query: 1160 KSLGISIVGGRGM---GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
            +  G  IV        G+   N  V     I  ++E SPA + G LK GDRI+ V+G  +
Sbjct: 1007 EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSI 1066

Query: 1217 RDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQI 1276
             + SH   V  I++AGN V   +           +P             S+N    +L  
Sbjct: 1067 TNKSHSDIVNLIKEAGNTVTLRI-----------IPG----------DESSNA---TLLT 1102

Query: 1277 NADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKN 1336
            NA+K           A + +   P     ++ G+  T+++         +E +F +    
Sbjct: 1103 NAEKI----------ATITTTHTP-----SQQGTQETRNTTKP-----KQESQFEF---- 1138

Query: 1337 IRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIAD 1396
             +    T   + + +ELE+G  G G SL G ++ + M ++++ +  +G A + G+++I D
Sbjct: 1139 -KAPQATQEQDFYTVELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKMRIGD 1196

Query: 1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN 1445
            E+LEING+      H  A  +IK    +V++   R   +V + A+ P N
Sbjct: 1197 EILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPN 1245



 Score = 95.1 bits (235), Expect = 6e-19
 Identities = 143/645 (22%), Positives = 248/645 (38%), Gaps = 113/645 (17%)

Query: 1483 HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYP 1541
            H +L K   G G  +   D     + IKSL   G AA DG+++ GD I++V+D  V+G+ 
Sbjct: 472  HTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531

Query: 1542 IEKFISLLKTAKMTVKLTIHA-------ENPDSQAVPSAAGAASGEKK----NSSQSLMV 1590
              + + + ++  +   + +          +PD          A  +K+    N  ++   
Sbjct: 532  HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591

Query: 1591 PQSGSPEPESIRNT--SRSSTPAIFASDPA------TCPIIPGCET-----TIEISKGRT 1637
            P S S +   +     +R S+PA  AS+ +      T  +     T     T+ I KG  
Sbjct: 592  PASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPM 651

Query: 1638 GLGLSIV---GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
            G G +I    GG    +  I+      +   C+   L  GD I+EVN  +++  TH++ +
Sbjct: 652  GFGFTIADSPGGGGQRVKQIV------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVV 703

Query: 1695 NVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDI 1754
            ++L + P+   +TL                 + + KK  K   L     +N +   VS  
Sbjct: 704  DMLVECPKGSEVTLLVQRGG-----------LPVPKKSPKSQPLERKDSQNSSQHSVSSH 752

Query: 1755 VKGGIADADGRLMQGDQILM------VNGEDVRNATQEAVAALLKVSEGSLSSFT----- 1803
                 A          Q+L           D  +++ +      K+   S S +      
Sbjct: 753  RSLHTASPS----HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMS 808

Query: 1804 -FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS-LGISIAGGVGSPLGDVPI 1861
              P SG S  E     +  N     I   +  ++     ++  G  I GG  +  G+ PI
Sbjct: 809  PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PI 865

Query: 1862 FIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG------SIEMQV 1915
            +I  + P G A    +LR GD ++ + GT   G +H   V L++ A+       ++  +V
Sbjct: 866  YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 925

Query: 1916 V------------------AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP--- 1954
            V                  +    + +T  ++ P  S  S   ++S S     +G     
Sbjct: 926  VFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGG 985

Query: 1955 ---------QCKSITLERGP-DGLGFSIVGGYGSPHGD---------LPIYVKTVFAKGA 1995
                     Q   + + RG  +G GF IV     P            +P  +  +     
Sbjct: 986  GSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSP 1045

Query: 1996 ASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
            A   G+LK GD+I+AVNG S+   +H + V ++K    TVTL ++
Sbjct: 1046 ADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1090



 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)

Query: 147  GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
            G GF ++G      GE  I++  I     A  DGRL+  D+++ ++G  +    +HQ  +
Sbjct: 850  GFGFRILG--GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 905

Query: 207  SILQKA--KDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH--------ME 256
             ++Q+A  +  V L + R  +   V    +  PS AS+  + + P               
Sbjct: 906  QLMQQAAKQGHVNLTVRR-KVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN 964

Query: 257  TIELVNDGSGL--GFGIIGGKATGVIVKTILP---------------------------- 286
            ++  V+ GSG   G G  GG  +GV+   + P                            
Sbjct: 965  SLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 1024

Query: 287  ------------------GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNR 328
                              G  AD+ G+L  GD IL +    +   S   +  ++++ GN 
Sbjct: 1025 TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084

Query: 329  VKLMIARGAIEERTAPTALG-------ITLSSSPTS--TPELRVDA-----------STQ 368
            V L I  G  +E +  T L        IT + +P+   T E R              + Q
Sbjct: 1085 VTLRIIPG--DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQ 1142

Query: 369  KGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428
              +E + + VEL +  +G G ++ G     +     ++V  + +    E  G+++IGD+I
Sbjct: 1143 ATQEQDFYTVELERGAKGFGFSLRG----GREYNMDLYVLRLAEDGPAERCGKMRIGDEI 1198

Query: 429  IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
            + ++G   +   + +A+E++++ G+ V L L R
Sbjct: 1199 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 134/658 (20%), Positives = 237/658 (36%), Gaps = 129/658 (19%)

Query: 1008 TINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
            T++I KG    G T++ +  G G  V+ I+      R   +  GD I+ +N+++  ++T+
Sbjct: 643  TVHIVKGPMGFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTH 699

Query: 1068 AQARAML-------------RRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF 1114
             Q   ML             +R  L  P       P E  +    S    S         
Sbjct: 700  NQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTAS 759

Query: 1115 SSYTGRDIPELPEREEGEGEESELQNTA----YSNWNQPRRVELWR--EPSKSLGISIVG 1168
             S++ + +PE P  E    ++++         +  W Q R +   R   PS + G+S  G
Sbjct: 760  PSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLS-KG 818

Query: 1169 GR-----------------------------GMGSRLSNG-EVMRGIFIKHVLEDSPAGK 1198
             R                             G G R+  G E    I+I H++    A  
Sbjct: 819  EREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADT 878

Query: 1199 NGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNP----------VVFMVQSIINRPRK 1248
            +G L+ GD ++ VDG  +   SH+  V+ +++A             VVF V    N   +
Sbjct: 879  DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN---E 935

Query: 1249 SPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEM 1308
             P P+  H+       SS  P               S +E ++ P  S            
Sbjct: 936  VPSPASSHH-------SSNQP--------------ASLTEEKRTPQGS------------ 962

Query: 1309 GSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS-GLGLSLAGN 1367
                 Q+S + +S         G           T+  + + +E+ +G + G G  +  +
Sbjct: 963  -----QNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV-QPYDVEIRRGENEGFGFVIVSS 1016

Query: 1368 KDRSR-----------MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASS 1416
              R             M   I  I     A + G+L++ D +L +NG  +  +SH +  +
Sbjct: 1017 VSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVN 1076

Query: 1417 IIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLS 1476
            +IK A + V +  I   ++ N   +     +  + +     Q    E   TT        
Sbjct: 1077 LIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQF 1136

Query: 1477 SFKNVQ--------HLELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGD 1527
             FK  Q         +EL +   G G ++    +    + +  L E G A   G++++GD
Sbjct: 1137 EFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGD 1196

Query: 1528 QILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN---PDSQAVPSAAGAASGEKK 1582
            +IL ++ E        + I L+K     V+L +   +   P+   +P    A    +K
Sbjct: 1197 EILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEK 1254



 Score = 72.4 bits (176), Expect = 4e-12
 Identities = 140/662 (21%), Positives = 249/662 (37%), Gaps = 143/662 (21%)

Query: 225  LPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVI--VK 282
            +P    P  +R+PS       H+           +L     G GF ++GG        +K
Sbjct: 451  VPLQGKPFFTRNPSELKGKFIHT-----------KLRKSSRGFGFTVVGGDEPDEFLQIK 499

Query: 283  TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GNRVKLMIARG---- 336
            +++  G A   G++ +GD I+ + DT + G +  QV ++ +    G  V L + RG    
Sbjct: 500  SLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559

Query: 337  --------------AIEER-----------------------------TAPTALGITLSS 353
                          AI ++                               P++     S+
Sbjct: 560  FDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN 619

Query: 354  SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKS 413
            S    P   V  ++    + E   V + K   G G TIA   G       G  VK I  S
Sbjct: 620  SSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGG-----GGQRVKQIVDS 674

Query: 414  SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH--TGQTVLLTLMRRGMKQEAELM 471
                    ++ GD I+ V+  N+Q  T+ Q V++L     G  V L + R G+    +  
Sbjct: 675  PRCRG---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSP 731

Query: 472  SREDV-TKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDA 530
              + +  KD+     N+S    +  +     S + +T +LP     +P   A+  +  D+
Sbjct: 732  KSQPLERKDSQ----NSSQHSVSSHRSLHTASPSHSTQVLPE----FPPAEAQAPDQTDS 783

Query: 531  QKQE------------------------AALLTKWQRIMGINY---------EIVVAHVS 557
              Q+                        A+ L+K +R   IN          +     + 
Sbjct: 784  SGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIF 843

Query: 558  KFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
             + + +G G  +   +G +      +I  ++P G     G+L SGDEL+ V+G  ++G++
Sbjct: 844  LWRKETGFGFRI---LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900

Query: 612  HQDVVNILKELPIE--VTMVCCRRTV--PPTTQSELDS------LDLCDIELTEKPHVDL 661
            HQ VV ++++   +  V +   R+ V   P T++E+ S             LTE+     
Sbjct: 901  HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960

Query: 662  GEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKG-SKGLGFSILDYQDP 720
            G    S  T       T    S     + +         +E+ +G ++G GF I+     
Sbjct: 961  GS-QNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSR 1019

Query: 721  IDPASTV--------IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
             +  +T           I  ++ G  A++ G+L  GDR++ VN  ++ N S  + V  +K
Sbjct: 1020 PEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1079

Query: 773  GA 774
             A
Sbjct: 1080 EA 1081



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 59/243 (24%), Positives = 106/243 (43%), Gaps = 50/243 (20%)

Query: 1726 IELQKKPGKGLGLSIVGK--RNDTGVF-----------VSDIVKGGIADADGRLMQGDQI 1772
            +E+++   +G G  IV    R + G             +  I++G  AD  G+L  GD+I
Sbjct: 999  VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058

Query: 1773 LMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSK------------ 1820
            L VNG  + N +   +  L+K +  +++    P   SS +  L ++ K            
Sbjct: 1059 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQ 1118

Query: 1821 --------------------KNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVP 1860
                                K   A++ Q   TVE+++G     G S+ GG      ++ 
Sbjct: 1119 QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERG-AKGFGFSLRGGREY---NMD 1174

Query: 1861 IFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGD 1920
            +++  +   G A +  K+R+GD I+ I G +T+ M H++A+ L+KN    + +  +  GD
Sbjct: 1175 LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL-FLKRGD 1233

Query: 1921 VSV 1923
             SV
Sbjct: 1234 GSV 1236



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 59/236 (25%), Positives = 103/236 (43%), Gaps = 41/236 (17%)

Query: 139  ELLKPPSGGLGFSVVGLRSENRGELGIF-----------VQEIQEGSVAHRDGRLKETDQ 187
            E+ +  + G GF +V   S +R E G             +  I EGS A R G+LK  D+
Sbjct: 1000 EIRRGENEGFGFVIVS--SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057

Query: 188  ILAINGQALDQTITHQQAISILQKAKDTVQLVIARG----------SLPQLVSPIVSRSP 237
            ILA+NG ++    +H   ++++++A +TV L I  G          +  ++ +   + +P
Sbjct: 1058 ILAVNGCSITNK-SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1116

Query: 238  SAASTISAHSNPVHWQHME---------------TIELVNDGSGLGFGIIGGKATGV--I 280
            S   T    +     Q  +               T+EL     G GF + GG+   +   
Sbjct: 1117 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1176

Query: 281  VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
            V  +   G A++ G++  GD IL+I       M   +  ++++  G RV+L + RG
Sbjct: 1177 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1232



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 104/479 (21%), Positives = 181/479 (37%), Gaps = 101/479 (21%)

Query: 379 ELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
           +L K+ +G G T+ G  GD+  E   + +KS+        DG+++ GD I++V+ T + G
Sbjct: 474 KLRKSSRGFGFTVVG--GDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529

Query: 439 FTNQQAVEVLRH--TGQTVLLTLMR-RGMKQEAELMSREDVTKDA--DLSPVNASIIKEN 493
            T+ Q V++ +    G +V L L R   +  + +  +   VT  A  D  P+  +  +E 
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVN-GQET 588

Query: 494 YEKDEDFLSSTRNTN------------ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKW 541
           Y+      S T   N            +      GYP          D     +++ T+ 
Sbjct: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP---------NDTVSLASSIATQ- 638

Query: 542 QRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLE 601
                   E++  H+ K     G  I+     G   ++ ++ + P      L  GD ++E
Sbjct: 639 -------PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVE 688

Query: 602 VNGITLLGENHQDVVNILKELP--IEVTMVCCRRTVP-PTTQSELDSLDLCDIELTEKPH 658
           VN   +    H  VV++L E P   EVT++  R  +P P    +   L+  D + + +  
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHS 748

Query: 659 VDLGEFIGSSETEDPVLAMTD-----------AGQSTEEVQAPLAMWEAGIQHIE----- 702
           V     + ++        + +              S ++   P  +W       E     
Sbjct: 749 VSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMS 808

Query: 703 ------LEKGSK-----------------------------GLGFSILDYQDPIDPASTV 727
                 L KG +                             G GF IL   +P +P    
Sbjct: 809 PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEP---- 864

Query: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL-KGAPSGTVRIGVAK 785
           I I  +VP G A+ DGRL  GD L+ V+   +   S +  V+ + + A  G V + V +
Sbjct: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 923



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 45/264 (17%)

Query: 578 IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI--EVTMVCCRRTV 635
           I+S++ +GP    GK+ +GD ++ VN   +LG  H  VV I + +PI   V +  CR   
Sbjct: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557

Query: 636 PPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETED----------PVLAMTDAGQS-- 683
            P    + ++  +  + + +K  +     +   ET D           V  M DA  S  
Sbjct: 558 LPFDPDDPNTSLVTSVAILDKEPI----IVNGQETYDSPASHSSKTGKVNGMKDARPSSP 613

Query: 684 --------------TEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
                         T  + + +A  +  +  + + KG  G GF+I D      P      
Sbjct: 614 ADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD-----SPGGGGQR 667

Query: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGT-VRIGVAK--- 785
           ++ +V    + +   L  GD ++ VN  N++  +  + V+ L   P G+ V + V +   
Sbjct: 668 VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724

Query: 786 PLPLSPEEGYVSAKEDSFLYPPHS 809
           P+P    +     ++DS     HS
Sbjct: 725 PVPKKSPKSQPLERKDSQNSSQHS 748



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 7/97 (7%)

Query: 700 HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNL 759
           H +L K S+G GF+++   +P +     + I+SLV  G A  DG++  GD ++ VND  +
Sbjct: 472 HTKLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527

Query: 760 ENSSLEEAVEALKGAPSGT---VRIGVAKPLPLSPEE 793
              +  + V+  +  P G    + +    PLP  P++
Sbjct: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDD 564


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score =  127 bits (318), Expect = 1e-28
 Identities = 192/866 (22%), Positives = 345/866 (39%), Gaps = 129/866 (14%)

Query: 941  EQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNV 1000
            +QQ + + T  WTE H       SA +P V+P+      E   E   +    +    +N 
Sbjct: 414  QQQQQQQQTEEWTEDH-------SALVPPVIPNHPPSNPEPARE---VPLQGKPFFTRNP 463

Query: 1001 S--KESFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSI 1057
            S  K  F  T  + K +   G TV    +    + ++S++  G  + DG++  GD I+S+
Sbjct: 464  SELKGKFIHT-KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522

Query: 1058 NEESTISVTNAQARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSG 1106
            N+   +  T+AQ   + +    IG  + +              P   L      L ++  
Sbjct: 523  NDTCVLGHTHAQVVKIFQSIP-IGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPI 581

Query: 1107 RVMALDIF------SSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSK 1160
             V   + +      SS TG+       R     + +   +  Y N        +  +P  
Sbjct: 582  IVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPEL 641

Query: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
                 + G  G G  +++     G  +K ++ DSP  +   LK GD IVEV+  +++  +
Sbjct: 642  ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALT 698

Query: 1221 HEQAVEAIRKA--GNPVVFMVQ-SIINRPRKSPLPSLL----------HNLYPKYNFSST 1267
            H Q V+ + +   G+ V  +VQ   +  P+KSP    L          H++    +  + 
Sbjct: 699  HNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA 758

Query: 1268 NPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDH-----TQSSASKISQ 1322
            +P + S Q+  +  P+++++  +        P P   +A+  S +     + S AS +S+
Sbjct: 759  SP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSK 817

Query: 1323 DVDKEDEFGYSWKNIRERYGTLTGELHM-------IELEKGHSGLGLSLAGNKDRSRMSV 1375
                        +  RE   T  GE  +       I L +  +G G  + G  +     +
Sbjct: 818  G-----------EREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGE-PI 865

Query: 1376 FIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDA 1435
            +I  I P GAA  DGRL+  DEL+ ++G  + G+SHQ    +++ A  +  +     +  
Sbjct: 866  YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 925

Query: 1436 VNQMAVCPGNAVEPLPSNSENLQNKE---TEPTVTTSDAAVDLSSFKNVQHLELPKDQGG 1492
            V   AV       P P++S +  N+    TE   T   +   L++  +          GG
Sbjct: 926  V--FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGG 983

Query: 1493 LG---------------IAISEEDTLSGVIIKSLT------------------------E 1513
             G               I   E +    VI+ S++                        E
Sbjct: 984  GGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIE 1043

Query: 1514 HGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSA 1573
               A   G+LKVGD+ILAV+   +        ++L+K A  TV L I         +P  
Sbjct: 1044 GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI---------IPGD 1094

Query: 1574 AGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCET--TIE 1631
              + +    N+ +   +  + +P  +  + T  ++ P   +      P     +   T+E
Sbjct: 1095 ESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVE 1154

Query: 1632 ISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHD 1691
            + +G  G G S+ GG +  +   ++  + E+G A + G++  GD+ILE+NG   +   H 
Sbjct: 1155 LERGAKGFGFSLRGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1213

Query: 1692 EAINVLRQTPQRVRLTLYRDEAPYKE 1717
             AI +++   +RVRL L R +    E
Sbjct: 1214 RAIELIKNGGRRVRLFLKRGDGSVPE 1239



 Score =  100 bits (248), Expect = 2e-20
 Identities = 89/385 (23%), Positives = 154/385 (40%), Gaps = 84/385 (21%)

Query: 1735 GLGLSIVGKRNDTG--VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL 1792
            G G  I+G  N+ G  +++  IV  G AD DGRL  GD+++ V+G  V   + + V  L+
Sbjct: 850  GFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLM 908

Query: 1793 ------------------------------------------------KVSEGSLSSFTF 1804
                                                            +  +GS +S   
Sbjct: 909  QQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNT 968

Query: 1805 PLSGSSTSESLESSSKKNA-LASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIF- 1862
              SGS ++  + S     + + S +     VE+++G  +  G  I   V  P        
Sbjct: 969  VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAG 1028

Query: 1863 ---IAMMHPTG------VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1913
               +AM H  G       A +  KL+VGDRI+ + G S    +H+  VNL+K A  ++ +
Sbjct: 1029 NACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1088

Query: 1914 QVVAGGDVS-------------VVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCK--- 1957
            +++ G + S             + T H      +  +          Q +   PQ     
Sbjct: 1089 RIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ 1148

Query: 1958 ---SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2014
               ++ LERG  G GFS+ GG      ++ +YV  +   G A   G+++ GD+I+ +NG+
Sbjct: 1149 DFYTVELERGAKGFGFSLRGG---REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGE 1205

Query: 2015 SLEGVTHEEAVAILKRTKGTVTLMV 2039
            + + + H  A+ ++K     V L +
Sbjct: 1206 TTKNMKHSRAIELIKNGGRRVRLFL 1230



 Score = 98.6 bits (244), Expect = 6e-20
 Identities = 153/669 (22%), Positives = 275/669 (41%), Gaps = 100/669 (14%)

Query: 125  LIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKE 184
            L  ++A    +    ++K P G  GF++    +++ G  G  V++I +     R   LKE
Sbjct: 631  LASSIATQPELITVHIVKGPMG-FGFTI----ADSPGGGGQRVKQIVDSP---RCRGLKE 682

Query: 185  TDQILAINGQALDQTITHQQAISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAAST 242
             D I+ +N + + Q +TH Q + +L +      V L++ RG L     P+  +SP     
Sbjct: 683  GDLIVEVNKKNV-QALTHNQVVDMLVECPKGSEVTLLVQRGGL-----PVPKKSPK---- 732

Query: 243  ISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHI 302
                S P+  +  +     +  S           +  ++    P                
Sbjct: 733  ----SQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPD--------- 779

Query: 303  LKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELR 362
                 TD +G       ++  Q         +R   E R    +    LS         R
Sbjct: 780  ----QTDSSGQKKPDPFKIWAQ---------SRSMYENRPMSPSPASGLSKGERE----R 822

Query: 363  VDASTQKGE----ESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEH 418
               ST  GE    + +  D+ L +   G G  I G  G++  EP  I++  I    A + 
Sbjct: 823  EINSTNFGECPIPDYQEQDIFLWRKETGFGFRILG--GNEPGEP--IYIGHIVPLGAADT 878

Query: 419  DGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT--VLLTLMRRGM----KQEAELMS 472
            DGR++ GD++I VDGT + G ++Q  V++++   +   V LT+ R+ +    K E E+ S
Sbjct: 879  DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPS 938

Query: 473  REDVTKDADLSPVNASIIKENYEKDEDFL----SSTRNTNILPTEEEGYPLLSAEIEEIE 528
                   ++  P + +  K   +  ++ L    S + +T+ + +   G   + + + +  
Sbjct: 939  PASSHHSSN-QPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPY 997

Query: 529  DAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGH-HFIRSVLPEGPV 587
            D + +            G  + ++V+ VS+    +G   +  A V   H I  ++   P 
Sbjct: 998  DVEIRRG-------ENEGFGF-VIVSSVSR--PEAGTTFAGNACVAMPHKIGRIIEGSPA 1047

Query: 588  GHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL- 646
               GKL  GD +L VNG ++  ++H D+VN++KE    VT+    R +P    S    L 
Sbjct: 1048 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL----RIIPGDESSNATLLT 1103

Query: 647  ---DLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIEL 703
                +  I  T  P        G+ ET +         +S  E +AP A  E     +EL
Sbjct: 1104 NAEKIATITTTHTPSQQ-----GTQETRN---TTKPKQESQFEFKAPQATQEQDFYTVEL 1155

Query: 704  EKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSS 763
            E+G+KG GFS+   ++     +  + +  L   G AE+ G++  GD ++ +N    +N  
Sbjct: 1156 ERGAKGFGFSLRGGRE----YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1211

Query: 764  LEEAVEALK 772
               A+E +K
Sbjct: 1212 HSRAIELIK 1220



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 143/646 (22%), Positives = 248/646 (38%), Gaps = 114/646 (17%)

Query: 1483 HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYP 1541
            H +L K   G G  +   D     + IKSL   G AA DG+++ GD I++V+D  V+G+ 
Sbjct: 472  HTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531

Query: 1542 IEKFISLLKTAKMTVKLTIHA-------ENPDSQAVPSAAGAASGEKK----NSSQSLMV 1590
              + + + ++  +   + +          +PD          A  +K+    N  ++   
Sbjct: 532  HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591

Query: 1591 PQSGSPEPESIRNT--SRSSTPAIFASDPA------TCPIIPGCET-----TIEISKGRT 1637
            P S S +   +     +R S+PA  AS+ +      T  +     T     T+ I KG  
Sbjct: 592  PASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPM 651

Query: 1638 GLGLSIV---GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
            G G +I    GG    +  I+      +   C+   L  GD I+EVN  +++  TH++ +
Sbjct: 652  GFGFTIADSPGGGGQRVKQIV------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVV 703

Query: 1695 NVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDI 1754
            ++L + P+   +TL                 + + KK  K   L     +N +   VS  
Sbjct: 704  DMLVECPKGSEVTLLVQRGG-----------LPVPKKSPKSQPLERKDSQNSSQHSVSSH 752

Query: 1755 VKGGIADADGRLMQGDQILM------VNGEDVRNATQEAVAALLKVSEGSLSSFT----- 1803
                 A          Q+L           D  +++ +      K+   S S +      
Sbjct: 753  RSLHTASPS----HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMS 808

Query: 1804 -FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS-LGISIAGGVGSPLGDVPI 1861
              P SG S  E     +  N     I   +  ++     ++  G  I GG  +  G+ PI
Sbjct: 809  PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PI 865

Query: 1862 FIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG------SIEMQV 1915
            +I  + P G A    +LR GD ++ + GT   G +H   V L++ A+       ++  +V
Sbjct: 866  YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 925

Query: 1916 V------------------AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP--- 1954
            V                  +    + +T  ++ P  S  S   ++S S     +G     
Sbjct: 926  VFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGG 985

Query: 1955 ---------QCKSITLERGP-DGLGFSIVGGYGSPHGD----------LPIYVKTVFAKG 1994
                     Q   + + RG  +G GF IV     P             +P  +  +    
Sbjct: 986  GSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGS 1045

Query: 1995 AASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
             A   G+LK GD+I+AVNG S+   +H + V ++K    TVTL ++
Sbjct: 1046 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1091



 Score = 88.6 bits (218), Expect = 6e-17
 Identities = 111/480 (23%), Positives = 194/480 (40%), Gaps = 101/480 (21%)

Query: 1006 ERTINIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
            E+ I + +  +  G  +   N+ G  + +  I+  GA   DGR+  GD ++ ++    I 
Sbjct: 839  EQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIG 898

Query: 1065 -----VTNAQARAMLRRHSLIGPDIKITYV--------------------PAEHLEEFKI 1099
                 V     +A  + H  +    K+ +                     PA   EE + 
Sbjct: 899  KSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRT 958

Query: 1100 SLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPS 1159
              G Q+    +L+  SS +G           G G      +   S   QP  VE+ R  +
Sbjct: 959  PQGSQN----SLNTVSSGSGST--------SGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006

Query: 1160 KSLGISIVGGRGMGSRLSNGEVMRG---IFIKH----VLEDSPAGKNGTLKPGDRIVEVD 1212
            +  G  IV      SR   G    G   + + H    ++E SPA + G LK GDRI+ V+
Sbjct: 1007 EGFGFVIVSSV---SRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVN 1063

Query: 1213 GMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFAD 1272
            G  + + SH   V  I++AGN V   +           +P             S+N    
Sbjct: 1064 GCSITNKSHSDIVNLIKEAGNTVTLRI-----------IPG----------DESSNA--- 1099

Query: 1273 SLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGY 1332
            +L  NA+K           A + +   P     ++ G+  T+++         +E +F +
Sbjct: 1100 TLLTNAEKI----------ATITTTHTP-----SQQGTQETRNTTKP-----KQESQFEF 1139

Query: 1333 SWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRL 1392
                 +    T   + + +ELE+G  G G SL G ++ + M ++++ +  +G A + G++
Sbjct: 1140 -----KAPQATQEQDFYTVELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKM 1193

Query: 1393 QIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPS 1452
            +I DE+LEING+      H  A  +IK    +V++   R   +V +     G+  E +PS
Sbjct: 1194 RIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYG---GSNYENIPS 1250



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 87/394 (22%), Positives = 159/394 (40%), Gaps = 90/394 (22%)

Query: 147  GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
            G GF ++G      GE  I++  I     A  DGRL+  D+++ ++G  +    +HQ  +
Sbjct: 850  GFGFRILG--GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 905

Query: 207  SILQKA--KDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH--------ME 256
             ++Q+A  +  V L + R  +   V    +  PS AS+  + + P               
Sbjct: 906  QLMQQAAKQGHVNLTVRR-KVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN 964

Query: 257  TIELVNDGSGL--GFGIIGGKATGVIVKTILP---------------------------- 286
            ++  V+ GSG   G G  GG  +GV+   + P                            
Sbjct: 965  SLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 1024

Query: 287  -------------------GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGN 327
                               G  AD+ G+L  GD IL +    +   S   +  ++++ GN
Sbjct: 1025 TFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1084

Query: 328  RVKLMIARGAIEERTAPTALG-------ITLSSSPTS--TPELRVDA-----------ST 367
             V L I  G  +E +  T L        IT + +P+   T E R              + 
Sbjct: 1085 TVTLRIIPG--DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAP 1142

Query: 368  QKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQ 427
            Q  +E + + VEL +  +G G ++ G     +     ++V  + +    E  G+++IGD+
Sbjct: 1143 QATQEQDFYTVELERGAKGFGFSLRG----GREYNMDLYVLRLAEDGPAERCGKMRIGDE 1198

Query: 428  IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
            I+ ++G   +   + +A+E++++ G+ V L L R
Sbjct: 1199 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1232



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 140/663 (21%), Positives = 249/663 (37%), Gaps = 144/663 (21%)

Query: 225  LPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVI--VK 282
            +P    P  +R+PS       H+           +L     G GF ++GG        +K
Sbjct: 451  VPLQGKPFFTRNPSELKGKFIHT-----------KLRKSSRGFGFTVVGGDEPDEFLQIK 499

Query: 283  TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GNRVKLMIARG---- 336
            +++  G A   G++ +GD I+ + DT + G +  QV ++ +    G  V L + RG    
Sbjct: 500  SLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559

Query: 337  --------------AIEER-----------------------------TAPTALGITLSS 353
                          AI ++                               P++     S+
Sbjct: 560  FDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN 619

Query: 354  SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKS 413
            S    P   V  ++    + E   V + K   G G TIA   G       G  VK I  S
Sbjct: 620  SSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGG-----GGQRVKQIVDS 674

Query: 414  SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH--TGQTVLLTLMRRGMKQEAELM 471
                    ++ GD I+ V+  N+Q  T+ Q V++L     G  V L + R G+    +  
Sbjct: 675  PRCRG---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSP 731

Query: 472  SREDV-TKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDA 530
              + +  KD+     N+S    +  +     S + +T +LP     +P   A+  +  D+
Sbjct: 732  KSQPLERKDSQ----NSSQHSVSSHRSLHTASPSHSTQVLPE----FPPAEAQAPDQTDS 783

Query: 531  QKQE------------------------AALLTKWQRIMGINY---------EIVVAHVS 557
              Q+                        A+ L+K +R   IN          +     + 
Sbjct: 784  SGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIF 843

Query: 558  KFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
             + + +G G  +   +G +      +I  ++P G     G+L SGDEL+ V+G  ++G++
Sbjct: 844  LWRKETGFGFRI---LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900

Query: 612  HQDVVNILKELPIE--VTMVCCRRTV--PPTTQSELDS------LDLCDIELTEKPHVDL 661
            HQ VV ++++   +  V +   R+ V   P T++E+ S             LTE+     
Sbjct: 901  HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960

Query: 662  GEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKG-SKGLGFSILDYQDP 720
            G    S  T       T    S     + +         +E+ +G ++G GF I+     
Sbjct: 961  GS-QNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSR 1019

Query: 721  IDPASTVI---------IIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
             +  +T            I  ++ G  A++ G+L  GDR++ VN  ++ N S  + V  +
Sbjct: 1020 PEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLI 1079

Query: 772  KGA 774
            K A
Sbjct: 1080 KEA 1082



 Score = 68.9 bits (167), Expect = 5e-11
 Identities = 64/264 (24%), Positives = 113/264 (42%), Gaps = 54/264 (20%)

Query: 1726 IELQKKPGKGLGLSIVGK--RNDTGVF------------VSDIVKGGIADADGRLMQGDQ 1771
            +E+++   +G G  IV    R + G              +  I++G  AD  G+L  GD+
Sbjct: 999  VEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1058

Query: 1772 ILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSK----------- 1820
            IL VNG  + N +   +  L+K +  +++    P   SS +  L ++ K           
Sbjct: 1059 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1118

Query: 1821 ---------------------KNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDV 1859
                                 K   A++ Q   TVE+++G     G S+ GG      ++
Sbjct: 1119 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERG-AKGFGFSLRGGREY---NM 1174

Query: 1860 PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAG- 1918
             +++  +   G A +  K+R+GD I+ I G +T+ M H++A+ L+KN    + + +  G 
Sbjct: 1175 DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGD 1234

Query: 1919 GDVSVVTGHQQEPASSSLSFTGLT 1942
            G V    G   E   +  SF G+T
Sbjct: 1235 GSVPEYGGSNYE---NIPSFPGMT 1255



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 59/237 (24%), Positives = 103/237 (43%), Gaps = 42/237 (17%)

Query: 139  ELLKPPSGGLGFSVVGLRSENRGELGIF------------VQEIQEGSVAHRDGRLKETD 186
            E+ +  + G GF +V   S +R E G              +  I EGS A R G+LK  D
Sbjct: 1000 EIRRGENEGFGFVIVS--SVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1057

Query: 187  QILAINGQALDQTITHQQAISILQKAKDTVQLVIARG----------SLPQLVSPIVSRS 236
            +ILA+NG ++    +H   ++++++A +TV L I  G          +  ++ +   + +
Sbjct: 1058 RILAVNGCSITNK-SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1116

Query: 237  PSAASTISAHSNPVHWQHME---------------TIELVNDGSGLGFGIIGGKATGV-- 279
            PS   T    +     Q  +               T+EL     G GF + GG+   +  
Sbjct: 1117 PSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDL 1176

Query: 280  IVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
             V  +   G A++ G++  GD IL+I       M   +  ++++  G RV+L + RG
Sbjct: 1177 YVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1233



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 104/479 (21%), Positives = 181/479 (37%), Gaps = 101/479 (21%)

Query: 379 ELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
           +L K+ +G G T+ G  GD+  E   + +KS+        DG+++ GD I++V+ T + G
Sbjct: 474 KLRKSSRGFGFTVVG--GDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529

Query: 439 FTNQQAVEVLRH--TGQTVLLTLMR-RGMKQEAELMSREDVTKDA--DLSPVNASIIKEN 493
            T+ Q V++ +    G +V L L R   +  + +  +   VT  A  D  P+  +  +E 
Sbjct: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVN-GQET 588

Query: 494 YEKDEDFLSSTRNTN------------ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKW 541
           Y+      S T   N            +      GYP          D     +++ T+ 
Sbjct: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP---------NDTVSLASSIATQ- 638

Query: 542 QRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLE 601
                   E++  H+ K     G  I+     G   ++ ++ + P      L  GD ++E
Sbjct: 639 -------PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVE 688

Query: 602 VNGITLLGENHQDVVNILKELP--IEVTMVCCRRTVP-PTTQSELDSLDLCDIELTEKPH 658
           VN   +    H  VV++L E P   EVT++  R  +P P    +   L+  D + + +  
Sbjct: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHS 748

Query: 659 VDLGEFIGSSETEDPVLAMTD-----------AGQSTEEVQAPLAMWEAGIQHIE----- 702
           V     + ++        + +              S ++   P  +W       E     
Sbjct: 749 VSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMS 808

Query: 703 ------LEKGSK-----------------------------GLGFSILDYQDPIDPASTV 727
                 L KG +                             G GF IL   +P +P    
Sbjct: 809 PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEP---- 864

Query: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL-KGAPSGTVRIGVAK 785
           I I  +VP G A+ DGRL  GD L+ V+   +   S +  V+ + + A  G V + V +
Sbjct: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 923



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 45/264 (17%)

Query: 578 IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI--EVTMVCCRRTV 635
           I+S++ +GP    GK+ +GD ++ VN   +LG  H  VV I + +PI   V +  CR   
Sbjct: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557

Query: 636 PPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETED----------PVLAMTDAGQS-- 683
            P    + ++  +  + + +K  +     +   ET D           V  M DA  S  
Sbjct: 558 LPFDPDDPNTSLVTSVAILDKEPI----IVNGQETYDSPASHSSKTGKVNGMKDARPSSP 613

Query: 684 --------------TEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
                         T  + + +A  +  +  + + KG  G GF+I D      P      
Sbjct: 614 ADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD-----SPGGGGQR 667

Query: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGT-VRIGVAK--- 785
           ++ +V    + +   L  GD ++ VN  N++  +  + V+ L   P G+ V + V +   
Sbjct: 668 VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724

Query: 786 PLPLSPEEGYVSAKEDSFLYPPHS 809
           P+P    +     ++DS     HS
Sbjct: 725 PVPKKSPKSQPLERKDSQNSSQHS 748



 Score = 45.8 bits (107), Expect = 4e-04
 Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 7/97 (7%)

Query: 700 HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNL 759
           H +L K S+G GF+++   +P +     + I+SLV  G A  DG++  GD ++ VND  +
Sbjct: 472 HTKLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527

Query: 760 ENSSLEEAVEALKGAPSGT---VRIGVAKPLPLSPEE 793
              +  + V+  +  P G    + +    PLP  P++
Sbjct: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDD 564


>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
          Length = 817

 Score =  125 bits (315), Expect = 3e-28
 Identities = 105/353 (29%), Positives = 155/353 (43%), Gaps = 69/353 (19%)

Query: 1730 KKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNA 1783
            ++   GLG SI G        +D G+F++ I+ GG A  DGRL   D +L VN  DV   
Sbjct: 135  ERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEV 194

Query: 1784 TQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS 1843
                    LK + G +               +E                 V + KGP   
Sbjct: 195  VHSRAVEALKEA-GPVVRLVVRRRQPPPETIME-----------------VNLLKGPK-G 235

Query: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
            LG SIAGG+G+    GD  I+I  +   G A +  +L++GDR++ +  T+ + + H +AV
Sbjct: 236  LGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAV 295

Query: 1902 NLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD----LG----- 1952
              LKN S  + ++V   G + +       P   + +FT L  + I  +     LG     
Sbjct: 296  ASLKNTSDMVYLKVAKPGSLHL--NDMYAPPDYASTFTALADNHISHNSSLGYLGAVESK 353

Query: 1953 -----PPQC----------------------KSITLERGPDGLGFSIVGGYGSPHGDLPI 1985
                 PPQ                       + I L +G  GLGF+IVGG         I
Sbjct: 354  VSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDGEG----I 409

Query: 1986 YVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
            +V  + A G A   G L+RGD+I++VNG +L   THE+A A LKR   +VT++
Sbjct: 410  FVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462



 Score =  117 bits (292), Expect = 2e-25
 Identities = 121/423 (28%), Positives = 180/423 (42%), Gaps = 97/423 (22%)

Query: 1567 SQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGC 1626
            SQ +PS AGA    +   +++ ++P      P   +     STP +  S P+  P    C
Sbjct: 56   SQTLPSQAGATPTPR---TKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSGPSWWP---EC 109

Query: 1627 ETT-------------------IEISKGRTGLGLSIVGGSDTLL----GAIIIHEVYEEG 1663
              T                   I + +G +GLG SI GG D         I I ++   G
Sbjct: 110  TCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGG 169

Query: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723
            AA  DGRL   D +L VN +D+ +  H  A+  L++    VRL + R + P +       
Sbjct: 170  AAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQPPPE-----TI 224

Query: 1724 LTIELQKKPGKGLGLSIVGK------RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNG 1777
            + + L K P KGLG SI G         D  ++++ I++GG A  DGRL  GD++L VN 
Sbjct: 225  MEVNLLKGP-KGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283

Query: 1778 ---EDVRNATQEAVAALLKVSE---------GS--LSSFTFPLSGSSTSESLE------- 1816
               +DVR+  +EAVA+L   S+         GS  L+    P   +ST  +L        
Sbjct: 284  TNLQDVRH--EEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHN 341

Query: 1817 --------------------------SSSKKNALASE--IQGLRTVEMKKGPTDSLGISI 1848
                                      S   ++ LA E   +  R + + KG T  LG +I
Sbjct: 342  SSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGST-GLGFNI 400

Query: 1849 AGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS 1908
             GG         IF++ +   G A  + +LR GDRI+++ G +    TH QA   LK A 
Sbjct: 401  VGGEDGE----GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAG 456

Query: 1909 GSI 1911
             S+
Sbjct: 457  QSV 459



 Score =  115 bits (287), Expect = 6e-25
 Identities = 100/385 (25%), Positives = 163/385 (42%), Gaps = 63/385 (16%)

Query: 256 ETIELVNDGSGLGFGIIGG-------KATGVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
           E I L    SGLGF I GG          G+ +  I+PGG A   GRL   D +L++ + 
Sbjct: 130 EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189

Query: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
           D++ +   +  + L++ G  V+L++ R     R  P              PE        
Sbjct: 190 DVSEVVHSRAVEALKEAGPVVRLVVRR-----RQPP--------------PET------- 223

Query: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
                   +V L K  +GLG +IAG IG++ +   + I++  I +  A + DGR+QIGD+
Sbjct: 224 ------IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDR 277

Query: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
           ++AV+ TNLQ   +++AV  L++T   V L + + G     ++ +  D          N 
Sbjct: 278 LLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADN- 336

Query: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEE---IEDAQKQEAALLTKWQRI 544
                ++     +L +  +    P   +  P   + I      E+   +E   +   +  
Sbjct: 337 ---HISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGS 393

Query: 545 MGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNG 604
            G+ + IV           G GI         F+  +L  GP   SG+L  GD +L VNG
Sbjct: 394 TGLGFNIV-------GGEDGEGI---------FVSFILAGGPADLSGELRRGDRILSVNG 437

Query: 605 ITLLGENHQDVVNILKELPIEVTMV 629
           + L    H+     LK     VT+V
Sbjct: 438 VNLRNATHEQAAAALKRAGQSVTIV 462



 Score =  107 bits (268), Expect = 9e-23
 Identities = 74/200 (37%), Positives = 98/200 (49%), Gaps = 35/200 (17%)

Query: 1844 LGISIAGGVGSPL--GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAV 1901
            LG SIAGG+ +P    D  IFI  + P G AA   +L V D ++ +       + H++AV
Sbjct: 141  LGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAV 200

Query: 1902 NLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITL 1961
              LK A          G  V +V   +Q P                     P     + L
Sbjct: 201  EALKEA----------GPVVRLVVRRRQPP---------------------PETIMEVNL 229

Query: 1962 ERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGV 2019
             +GP GLGFSI GG G+ H  GD  IY+  +   GAA +DGRL+ GD+++AVN  +L+ V
Sbjct: 230  LKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDV 289

Query: 2020 THEEAVAILKRTKGTVTLMV 2039
             HEEAVA LK T   V L V
Sbjct: 290  RHEEAVASLKNTSDMVYLKV 309



 Score =  106 bits (264), Expect = 3e-22
 Identities = 108/386 (27%), Positives = 161/386 (41%), Gaps = 65/386 (16%)

Query: 1351 IELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
            I LE+G+SGLG S+AG  D   +     +FI  I P GAA  DGRL + D +L +N   +
Sbjct: 132  IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

Query: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466
                H  A   +K A   V+++  R                +P P           E  +
Sbjct: 192  SEVVHSRAVEALKEAGPVVRLVVRRR---------------QPPPETI-------MEVNL 229

Query: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVG 1526
                  +  S    + +  +P D              + + I  + E G A  DGRL++G
Sbjct: 230  LKGPKGLGFSIAGGIGNQHIPGD--------------NSIYITKIIEGGAAQKDGRLQIG 275

Query: 1527 DQILAVDDEIVVGYPIEKFISLLKTAKMTVKL------TIHAEN---PDSQAVPSAAGAA 1577
            D++LAV++  +     E+ ++ LK     V L      ++H  +   P   A    A A 
Sbjct: 276  DRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALAD 335

Query: 1578 SGEKKNSSQSLMVPQSGS---PEPESIRNTSRSSTPA-IFASDPATCPIIPGCETTIEIS 1633
            +    NSS   +         P P  +  T  S  P  + A +  T          I + 
Sbjct: 336  NHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTRE-----PRKIILH 390

Query: 1634 KGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEA 1693
            KG TGLG +IVGG D     I +  +   G A   G L  GD+IL VNG++LR ATH++A
Sbjct: 391  KGSTGLGFNIVGGEDG--EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448

Query: 1694 INVLRQTPQRVRLTLYRDEAPYKEEE 1719
               L++  Q V +      A Y+ EE
Sbjct: 449  AAALKRAGQSVTIV-----AQYRPEE 469



 Score =  104 bits (259), Expect = 1e-21
 Identities = 101/408 (24%), Positives = 166/408 (40%), Gaps = 85/408 (20%)

Query: 107 GPGIPHINGK-----PAC-----DEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLR 156
           G   P +NG      P C     D ++Q+  +    ++ E+  +L+  + GLGFS+ G  
Sbjct: 92  GKSTPKLNGSGPSWWPECTCTNRDWYEQVNGSDGMFKYEEI--VLERGNSGLGFSIAGGI 149

Query: 157 SENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKD 214
                  + GIF+ +I  G  A  DGRL   D +L +N   + + + H +A+  L++A  
Sbjct: 150 DNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE-VVHSRAVEALKEAGP 208

Query: 215 TVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274
            V+LV+ R   P                          + +  + L+    GLGF I GG
Sbjct: 209 VVRLVVRRRQPPP-------------------------ETIMEVNLLKGPKGLGFSIAGG 243

Query: 275 KA-------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGN 327
                      + +  I+ GG A + GRL  GD +L + +T+L  +  E+    L+   +
Sbjct: 244 IGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSD 303

Query: 328 RVKLMIARGA---IEERTAPTALGITLSS-------------------------SPTSTP 359
            V L +A+     + +  AP     T ++                         +P   P
Sbjct: 304 MVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVP 363

Query: 360 ELRVDASTQKGEESETFDVE-----LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSS 414
             R     +     E F  E     L K   GLG  I G  G+   +  GIFV  I    
Sbjct: 364 PTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVG--GE---DGEGIFVSFILAGG 418

Query: 415 AVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
             +  G ++ GD+I++V+G NL+  T++QA   L+  GQ+V +    R
Sbjct: 419 PADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYR 466



 Score = 97.4 bits (241), Expect = 1e-19
 Identities = 85/298 (28%), Positives = 143/298 (47%), Gaps = 46/298 (15%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            +N+ KG   LG +++    G+G         + +  II GGA  +DGR+ IGD +L++N 
Sbjct: 227  VNLLKGPKGLGFSIAG---GIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283

Query: 1060 ESTISVTNAQARAMLRRHSLI---------GPDIKITYVPAEHLEEFK------ISLGQQ 1104
             +   V + +A A L+  S +            +   Y P ++   F       IS    
Sbjct: 284  TNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSS 343

Query: 1105 SGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGI 1164
             G + A++   SY     P++P           L    ++   +PR++ L  + S  LG 
Sbjct: 344  LGYLGAVESKVSYPAP--PQVPPTRYSPIPRHMLAEEDFTR--EPRKIIL-HKGSTGLGF 398

Query: 1165 SIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQA 1224
            +IVGG        +GE   GIF+  +L   PA  +G L+ GDRI+ V+G++LR+A+HEQA
Sbjct: 399  NIVGGE-------DGE---GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQA 448

Query: 1225 VEAIRKAGNPVVFMVQSIINRPRK-SPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
              A+++AG  V  + Q    RP + S   S +H+L  +   SS +  + SL+ +  ++
Sbjct: 449  AAALKRAGQSVTIVAQ---YRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRS 503



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 74/279 (26%), Positives = 125/279 (44%), Gaps = 45/279 (16%)

Query: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
            V L + P K LG SI GG  +G++   G+    I+I  ++E   A K+G L+ GDR++ V
Sbjct: 227  VNLLKGP-KGLGFSIAGG--IGNQHIPGD--NSIYITKIIEGGAAQKDGRLQIGDRLLAV 281

Query: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLH--NLYPKYNFSSTNP 1269
            +  +L+D  HE+AV +++   + V   V            P  LH  ++Y   +++ST  
Sbjct: 282  NNTNLQDVRHEEAVASLKNTSDMVYLKVAK----------PGSLHLNDMYAPPDYASTFT 331

Query: 1270 FADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDE 1329
                  I+ + +     +   K    + P  PP+ +            S I + +  E++
Sbjct: 332  ALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRY------------SPIPRHMLAEED 379

Query: 1330 FGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKD 1389
            F              T E   I L KG +GLG ++ G +D     +F+  I   G A   
Sbjct: 380  F--------------TREPRKIILHKGSTGLGFNIVGGEDGE--GIFVSFILAGGPADLS 423

Query: 1390 GRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKII 1428
            G L+  D +L +NG  L   +H+ A++ +K A   V I+
Sbjct: 424  GELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIV 462



 Score = 76.3 bits (186), Expect = 3e-13
 Identities = 98/387 (25%), Positives = 159/387 (41%), Gaps = 71/387 (18%)

Query: 699  QHIELEKGSKGLGFSILDYQD-PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
            + I LE+G+ GLGFSI    D P  P    I I  ++PGG A  DGRL   D ++ VN+V
Sbjct: 130  EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189

Query: 758  NLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGLAD 817
            ++       AVEALK A    VR+ V +  P                 PP +  E  L  
Sbjct: 190  DVSEVVHSRAVEALKEA-GPVVRLVVRRRQP-----------------PPETIMEVNL-- 229

Query: 818  KPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDG-LNYGSS 876
                     L G             + + P ++SIY T+   +   G++  DG L  G  
Sbjct: 230  ---------LKGPKGLGFSIAGGIGNQHIPGDNSIYITK---IIEGGAAQKDGRLQIGDR 277

Query: 877  LPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTIND-YT 935
            L +      + N+         +L+++  +  +      +  V + +       +ND Y 
Sbjct: 278  LLA------VNNT---------NLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYA 322

Query: 936  PAN------AIEQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLA 989
            P +      A+   +   N+ +     + S+V   A  P V P        ++L +    
Sbjct: 323  PPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAP-PQVPPTRYSPIPRHMLAE---- 377

Query: 990  CNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIA 1049
                    ++ ++E   R I + KG++ LG  +   +DG G+ V  I+ GG     G + 
Sbjct: 378  --------EDFTRE--PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELR 427

Query: 1050 IGDCILSINEESTISVTNAQARAMLRR 1076
             GD ILS+N  +  + T+ QA A L+R
Sbjct: 428  RGDRILSVNGVNLRNATHEQAAAALKR 454



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 89/330 (26%), Positives = 125/330 (37%), Gaps = 87/330 (26%)

Query: 562 NSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQ 613
           NSGLG S+   + +         FI  ++P G     G+L   D +L VN + +    H 
Sbjct: 138 NSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHS 197

Query: 614 DVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDP 673
             V  LKE    V +V  RR  PP T  E++ L         K    LG  I        
Sbjct: 198 RAVEALKEAGPVVRLVVRRRQPPPETIMEVNLL---------KGPKGLGFSIAGG----- 243

Query: 674 VLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSL 733
                                  G QHI                     P    I I  +
Sbjct: 244 ----------------------IGNQHI---------------------PGDNSIYITKI 260

Query: 734 VPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEE 793
           + GG A+KDGRL  GDRL+ VN+ NL++   EEAV +LK   S  V + VAKP  L    
Sbjct: 261 IEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNT-SDMVYLKVAKPGSLH--- 316

Query: 794 GYVSAKEDSFLYPPHSCEEAGLADKPL-FRADLALVGTNDADLVDESTFESP---YSP-- 847
                  D +  P ++     LAD  +   + L  +G  ++ +   +  + P   YSP  
Sbjct: 317 -----LNDMYAPPDYASTFTALADNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIP 371

Query: 848 -----ENDSIYSTQASILSLHGSSCGDGLN 872
                E D  ++ +   + LH  S G G N
Sbjct: 372 RHMLAEED--FTREPRKIILHKGSTGLGFN 399



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 66/255 (25%), Positives = 104/255 (40%), Gaps = 32/255 (12%)

Query: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
           +  V+      GLG S+   +G+         +I  ++  G     G+L  GD LL VN 
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283

Query: 605 ITLLGENHQDVVNILKELPIEVTMVCCR--------RTVPPTTQSELDSLDLCDIELTEK 656
             L    H++ V  LK     V +   +           PP   S   +L   D  ++  
Sbjct: 284 TNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTAL--ADNHISHN 341

Query: 657 PHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAM-----WEAGIQHIELEKGSKGLG 711
             +    ++G+ E++    A       T     P  M     +    + I L KGS GLG
Sbjct: 342 SSLG---YLGAVESKVSYPAPPQV-PPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLG 397

Query: 712 FSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL 771
           F+I+  +D        I +  ++ GG A+  G L  GDR++ VN VNL N++ E+A  AL
Sbjct: 398 FNIVGGED-----GEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAAL 452

Query: 772 KGAPSGTVRIGVAKP 786
           K A      +   +P
Sbjct: 453 KRAGQSVTIVAQYRP 467



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 36/85 (42%), Positives = 46/85 (54%), Gaps = 2/85 (2%)

Query: 1957 KSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2014
            + I LERG  GLGFSI GG  +PH   D  I++  +   GAA+ DGRL   D ++ VN  
Sbjct: 130  EEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEV 189

Query: 2015 SLEGVTHEEAVAILKRTKGTVTLMV 2039
             +  V H  AV  LK     V L+V
Sbjct: 190  DVSEVVHSRAVEALKEAGPVVRLVV 214



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 66/264 (25%), Positives = 98/264 (37%), Gaps = 27/264 (10%)

Query: 1351 IELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
            + L KG  GLG S+AG      +    S++I  I   GAA KDGRLQI D LL +N   L
Sbjct: 227  VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286

Query: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDA-VNQMAVCPG--------------------- 1444
                H+ A + +K     V +   +     +N M   P                      
Sbjct: 287  QDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLGY 346

Query: 1445 -NAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTL 1503
              AVE   S     Q   T  +        +    +  + + L K   GLG  I   +  
Sbjct: 347  LGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGGEDG 406

Query: 1504 SGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAE 1563
             G+ +  +   G A   G L+ GD+IL+V+   +     E+  + LK A  +V +     
Sbjct: 407  EGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYR 466

Query: 1564 NPDSQAVPSAAGAASGEKKNSSQS 1587
              +     S       +  NSS S
Sbjct: 467  PEEYSRFESKIHDLREQMMNSSMS 490



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 26/84 (30%), Positives = 45/84 (53%), Gaps = 9/84 (10%)

Query: 1009 INIAKGNSSLGMTVSAN------KDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++         D  G+ +  II GGA + DGR+ + DC+L +NE   
Sbjct: 132  IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKI 1086
              V +++A   L+     GP +++
Sbjct: 192  SEVVHSRAVEALKE---AGPVVRL 212



 Score = 43.1 bits (100), Expect = 0.003
 Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 9/83 (10%)

Query: 1159 SKSLGISIVGGRGMGSRLSNGEVMR--GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
            +  LG SI GG      + N  V    GIFI  ++    A  +G L   D ++ V+ +D+
Sbjct: 138  NSGLGFSIAGG------IDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191

Query: 1217 RDASHEQAVEAIRKAGNPVVFMV 1239
             +  H +AVEA+++AG PVV +V
Sbjct: 192  SEVVHSRAVEALKEAG-PVVRLV 213


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score =  124 bits (310), Expect = 1e-27
 Identities = 119/498 (23%), Positives = 213/498 (42%), Gaps = 80/498 (16%)

Query: 1346 GELHMIELEKGHSGLGLSLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            G +  +EL K   GLG+ ++G +   RS  ++ +  +   GAA +DGRL + DELL ING
Sbjct: 330  GRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVING 389

Query: 1404 QILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETE 1463
             +L G SH+ A +I++ A   V+++    +++   +      ++  L S+ E++ +  T+
Sbjct: 390  HLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDV-SSWTD 448

Query: 1464 PTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRL 1523
                 +D   D  +  +VQ      D+         +D             G   + G L
Sbjct: 449  NEDQEADGEEDEGTSSSVQRAMPGTDE--------PQDVC-----------GAEESKGNL 489

Query: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKN 1583
            +   Q     ++I +   +   +  L++ +   +L +   +P  + +      +   +K+
Sbjct: 490  ESPKQ---GSNKIKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLE----VSRDGRKH 542

Query: 1584 SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGR-TGLGLS 1642
            S   L+   S S E   ++ ++RS +     S      I P   + I + K +  GLG S
Sbjct: 543  SLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRL--IRPSVISIIGLYKEKGKGLGFS 600

Query: 1643 IVGGSDTLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQT 1700
            I GG D + G   I +  ++  G+A +DGRL  GD+IL+VNGI ++  T  EAI+  +Q 
Sbjct: 601  IAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQI 660

Query: 1701 PQRVRLTLYRDEAPYKEEEVCDTLT----------------------------------- 1725
               + +   R +        C T T                                   
Sbjct: 661  RSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPG 720

Query: 1726 --------IELQKKPGKGLGLS---IVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILM 1774
                    + L K+P  GLG+    +  + +  G+++  +  G +A  +  L +GDQIL 
Sbjct: 721  PKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780

Query: 1775 VNGEDVRNATQEAVAALL 1792
            VN  +VR+A    V A+L
Sbjct: 781  VNSVNVRHAALSKVHAIL 798



 Score =  102 bits (255), Expect = 3e-21
 Identities = 144/621 (23%), Positives = 243/621 (39%), Gaps = 160/621 (25%)

Query: 1508 IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEK--------------FISLLKTAK 1553
            +  L ++  A   G++++ D+IL+++ +++VG  +                ++ +L+  K
Sbjct: 121  VTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGASYLAEQCWNGGFIYLIMLRRFK 180

Query: 1554 MTVKLTIHAENPDSQAVPSAAGAASGEK--KNSSQSLMVPQSGSPEPESIRNTSRSSTPA 1611
                 T +  + +S           G++  K   ++        P        S+ S   
Sbjct: 181  HKAHSTYNGNSSNSSEPGETPTLELGDRTAKKGKRTRKFGVISRPPANKAPEESKGSAGC 240

Query: 1612 IFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRL 1671
              +SDP+T                       +  G D  LG   + ++ E G        
Sbjct: 241  EVSSDPST----------------------ELENGPDPELGNGHVFQL-ENGP------- 270

Query: 1672 WAGDQILEVNGIDLRKATHDEAINVLRQTPQRVR-----LTLYRDEAPYKE--------- 1717
               D + EV G  L ++  D      R T  R+      LT   D+  + +         
Sbjct: 271  ---DSLKEVAGPHLERSEVD------RGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSS 321

Query: 1718 -----EEVCDTLTIELQKKPGKGLGLSIVG----KRNDTGVFVSDIVKGGIADADGRLMQ 1768
                 EEV     +EL K+   GLG+ + G    KR+   + V+ + +GG A  DGRL  
Sbjct: 322  DCLAREEVGRIWKMELLKE-SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSL 380

Query: 1769 GDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSS------TSESLE------ 1816
            GD++L++NG  +   + E   A+L+ + G +         S+      TS+SL       
Sbjct: 381  GDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSV 440

Query: 1817 ----------------------SSSKKNAL--ASEIQGLRTVEMKKGPTDS--------- 1843
                                  SSS + A+    E Q +   E  KG  +S         
Sbjct: 441  EDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIK 500

Query: 1844 LGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNL 1903
            L   ++GGV   L  V  +  +M           +R GD  + +   S +G  H+    L
Sbjct: 501  LKSRLSGGVHR-LESVEEYNELM-----------VRNGDPRIRMLEVSRDGRKHSLP-QL 547

Query: 1904 LKNASGSIEMQVVAGGDVSVVTGHQQEP----ASSSLSFTGLTSSSIFQDDLGPPQCKSI 1959
            L ++S S E  +V     S+ T   + P      S +S  GL                  
Sbjct: 548  LDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYK---------------- 591

Query: 1960 TLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGV 2019
              E+G  GLGFSI GG     G + I+VKT+F  G+A+EDGRLK GD+I+ VNG  ++G+
Sbjct: 592  --EKGK-GLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648

Query: 2020 THEEAVAILKRTKGTVTLMVL 2040
            T +EA+   K+ +  + ++ +
Sbjct: 649  TFQEAIHTFKQIRSGLFVLTV 669



 Score = 97.8 bits (242), Expect = 9e-20
 Identities = 137/541 (25%), Positives = 224/541 (41%), Gaps = 83/541 (15%)

Query: 139 ELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
           ELLK  S GLG  V G R   R    I V +++EG  AHRDGRL   D++L ING  L  
Sbjct: 336 ELLKE-SDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLL-V 393

Query: 199 TITHQQAISILQKAKDTVQLVIA--RGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHME 256
            ++H++A++IL+ A   VQLV+A    S   L+       P   S++   S+   W   E
Sbjct: 394 GLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSS---WTDNE 450

Query: 257 TIELVNDGSGLGFGIIGGKATGVIVKTILPG--------GVADQHGRLCS---GDHILKI 305
             E   DG          + T   V+  +PG        G  +  G L S   G + +K+
Sbjct: 451 DQEA--DGE-------EDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKL 501

Query: 306 GDTDLAGM----SSEQVAQVLRQCGN-RVKLMIARGAIEERTAPTALGITLSS------- 353
                 G+    S E+  +++ + G+ R++++       + + P  L  + +S       
Sbjct: 502 KSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVK 561

Query: 354 -SPTSTPELRVDASTQKGEESETFDVELTKNV-QGLGITIAGYIGDKKLEPSGIFVKSIT 411
            S  S    +V++  +    S    + L K   +GLG +IAG   D      GIFVK+I 
Sbjct: 562 KSTRSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGG-RDCIRGQMGIFVKTIF 620

Query: 412 KSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELM 471
            + +   DGR++ GD+I+ V+G  ++G T Q+A+   +     + +  +R       +L+
Sbjct: 621 PNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR------TKLV 674

Query: 472 SREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQ 531
           S         L+P +               S++ N N       G               
Sbjct: 675 S-------PSLTPCSTPTHMSR--------SASPNFNTSGGASAG--------------G 705

Query: 532 KQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGI-----SLEATVGHHFIRSVLPEGP 586
             E +  +  ++  G    IV+          GLGI     +LE +    +I S+ P   
Sbjct: 706 SDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSV 765

Query: 587 VGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI-EVTMVCCRRTVPPTTQSELDS 645
                 L  GD++LEVN + +       V  IL + P   V +V  R   P  ++ E+D 
Sbjct: 766 AKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDE 825

Query: 646 L 646
           +
Sbjct: 826 V 826



 Score = 97.1 bits (240), Expect = 2e-19
 Identities = 121/481 (25%), Positives = 188/481 (39%), Gaps = 76/481 (15%)

Query: 1630 IEISKGRTGLGLSIVGGSDTLLG--AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRK 1687
            +E+ K   GLG+ + GG  +     AI++ +V E GAA +DGRL  GD++L +NG  L  
Sbjct: 335  MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394

Query: 1688 ATHDEAINVLRQTPQRVRLTLYRDEAPYKE------------------------------ 1717
             +H+EA+ +LR     V+L +   E   ++                              
Sbjct: 395  LSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEA 454

Query: 1718 --EEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQG----DQ 1771
              EE   T +   +  PG      + G     G   S            RL  G    + 
Sbjct: 455  DGEEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRLES 514

Query: 1772 ILMVNGEDVRNATQEAVAALLKVS-EGSLSSFTFPLSGSSTSESLESSSKKNALASEIQG 1830
            +   N   VRN        +L+VS +G   S    L  SS S+      K     S  Q 
Sbjct: 515  VEEYNELMVRNGDPRI--RMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQV 572

Query: 1831 -----------LRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
                       +  + + K     LG SIAGG     G + IF+  + P G AA+  +L+
Sbjct: 573  ESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLK 632

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSV------VTGHQQEPAS 1933
             GD I+ + G   +G+T  +A++  K     + +  V    VS          H    AS
Sbjct: 633  EGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSAS 692

Query: 1934 SSLSFTGL---------TSSSIFQDDLGPPQ--CKSITLERGPD---GLGFSIVGGYGSP 1979
             + + +G          +SSS+ +   GP       +TL + P    G+G   +    SP
Sbjct: 693  PNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSP 752

Query: 1980 HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAIL-KRTKGTVTLM 2038
             G   IY+ ++     A  +  L RGDQI+ VN  ++      +  AIL K   G V L+
Sbjct: 753  PG---IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLV 809

Query: 2039 V 2039
            +
Sbjct: 810  I 810



 Score = 93.6 bits (231), Expect = 2e-18
 Identities = 128/576 (22%), Positives = 230/576 (39%), Gaps = 116/576 (20%)

Query: 1449 PLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAIS----EEDTLS 1504
            PL ++++  +  +   T   S   +       +  +EL K+  GLGI +S     + +  
Sbjct: 300  PLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPH 359

Query: 1505 GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN 1564
             +++  + E G A  DGRL +GD++L ++  ++VG   E+ +++L++A   V+L + ++ 
Sbjct: 360  AIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKE 419

Query: 1565 PD--------SQAVPSAAGA--------------ASGEK-KNSSQSLMVPQSGSPEPESI 1601
                      S+++P    +              A GE+ + +S S+     G+ EP+ +
Sbjct: 420  NSAEDLLRLTSKSLPDLTSSVEDVSSWTDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDV 479

Query: 1602 RNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYE 1661
                 S                 G   + +    +  L   + GG   L      +E+  
Sbjct: 480  CGAEESK----------------GNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNELMV 523

Query: 1662 EGA--------ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEA 1713
                         +DGR  +  Q+L+        ++  +  ++++++ + +  T  + E+
Sbjct: 524  RNGDPRIRMLEVSRDGRKHSLPQLLD-------SSSASQEYHIVKKSTRSLSTT--QVES 574

Query: 1714 PYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN----DTGVFVSDIVKGGIADADGRLMQG 1769
            P++         I L K+ GKGLG SI G R+      G+FV  I   G A  DGRL +G
Sbjct: 575  PWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEG 634

Query: 1770 DQILMVNGEDVRNAT-QEAVAALLKVSEG-------------SLSSFTFPL--------- 1806
            D+IL VNG  ++  T QEA+    ++  G             SL+  + P          
Sbjct: 635  DEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPN 694

Query: 1807 ----SGSSTSESLESSSKKNALASEIQG-----LRTVEMKKGPTDSLGISIA--GGVGSP 1855
                 G+S   S E SS  ++L  +  G     +  V + K P   LGI         SP
Sbjct: 695  FNTSGGASAGGSDEGSS--SSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSP 752

Query: 1856 LGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIE--M 1913
             G   I+I  + P  VA     L  GD+I+ +            +VN+   A   +   +
Sbjct: 753  PG---IYIHSLAPGSVAKMESNLSRGDQILEV-----------NSVNVRHAALSKVHAIL 798

Query: 1914 QVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQD 1949
                 G V +V G    P  S      + + S +Q+
Sbjct: 799  SKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQE 834



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 151/643 (23%), Positives = 250/643 (38%), Gaps = 140/643 (21%)

Query: 1009 INIAKGNSSLGMTVSANKDGL----GMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
            + + K +  LG+ VS  +        ++V  +  GGA  RDGR+++GD +L IN    + 
Sbjct: 335  MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394

Query: 1065 VTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQS--GRVMALDIFSSYTGRDI 1122
            +++ +A A+LR  + +   +++     E+  E  + L  +S      +++  SS+T  + 
Sbjct: 395  LSHEEAVAILRSATGM---VQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451

Query: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
             E  + EE EG  S +Q  A    ++P+ V                    G+  S G + 
Sbjct: 452  QEA-DGEEDEGTSSSVQR-AMPGTDEPQDV-------------------CGAEESKGNL- 489

Query: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
                      +SP   +  +K   R+    G   R  S E+  E + + G+P + M++ +
Sbjct: 490  ----------ESPKQGSNKIKLKSRL---SGGVHRLESVEEYNELMVRNGDPRIRMLE-V 535

Query: 1243 INRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPP 1302
                RK  LP LL +      +        SL     ++P                    
Sbjct: 536  SRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESP-------------------- 575

Query: 1303 SAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGL 1362
                                           W+ IR    ++ G    +  EKG  GLG 
Sbjct: 576  -------------------------------WRLIRPSVISIIG----LYKEKG-KGLGF 599

Query: 1363 SLAGNKD--RSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKC 1420
            S+AG +D  R +M +F+  I PNG+A +DGRL+  DE+L++NG  + G + Q A    K 
Sbjct: 600  SIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQ 659

Query: 1421 APSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAV-----DL 1475
              S + ++ +R K       V P       P ++    ++   P   TS  A      + 
Sbjct: 660  IRSGLFVLTVRTK------LVSPSLT----PCSTPTHMSRSASPNFNTSGGASAGGSDEG 709

Query: 1476 SSFKNVQHLELPKD------------QGGLGI---AISEEDTLSGVIIKSLTEHGVAATD 1520
            SS    +    PKD            + GLGI    ++ E++  G+ I SL    VA  +
Sbjct: 710  SSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKME 769

Query: 1521 GRLKVGDQILAVDDEIVVGYPIEKFISLL-KTAKMTVKLTI-HAENP-----DSQAVPSA 1573
              L  GDQIL V+   V    + K  ++L K     V+L I    NP     +   V + 
Sbjct: 770  SNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIAR 829

Query: 1574 AGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASD 1616
            +     ++ NSS  L  P       +     S S     FA D
Sbjct: 830  STYQESKEANSSPGLGTPLKSPSLAKKDSLISESELSQYFAHD 872



 Score = 78.6 bits (192), Expect = 6e-14
 Identities = 74/262 (28%), Positives = 120/262 (45%), Gaps = 23/262 (8%)

Query: 1792 LKVSEGS---LSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISI 1848
            L VS G    L S    +   ST  +L   +K  +   E      +  K+G    LG S+
Sbjct: 2580 LLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEG--SGLGFSV 2637

Query: 1849 AGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS 1908
            AGG  + +    I +  +   G A+Q   +  GD ++++ G S  G+ H   + +L  A 
Sbjct: 2638 AGG--TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQ 2695

Query: 1909 GSIEMQVVA--GGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLE---- 1962
               +  VV   G D    +  Q+ P ++     GL S       L P   +S+ +     
Sbjct: 2696 LHKDALVVIKKGMDQPRPSARQEPPTANG---KGLLSRKTIP--LEPGIGRSVAVHDALC 2750

Query: 1963 ----RGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEG 2018
                +   GLG S+ GG  S  GD P+ +K V+  GAA + G ++ GD+I+A+NG+ L G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810

Query: 2019 VTHEEAVAILKRT-KGTVTLMV 2039
            + H +A  I+K   +G V L++
Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLI 2832



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 67/261 (25%), Positives = 116/261 (44%), Gaps = 20/261 (7%)

Query: 217  QLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELV----NDGSGLGFGII 272
            QL+++ G   +L S + S    +             ++ E +  +     +GSGLGF + 
Sbjct: 2579 QLLVSAGDQQRLQSVLSSVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVA 2638

Query: 273  GG---KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327
            GG   +   + V  +   G A Q G +  GD +L +    LAG++   V +VL Q     
Sbjct: 2639 GGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHK 2698

Query: 328  RVKLMIARGAIEERTA-----PTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382
               ++I +G  + R +     PTA G  L S  T   E  +  S       +   VE+ K
Sbjct: 2699 DALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSV---AVHDALCVEVLK 2755

Query: 383  NVQGLGITIAGYIGDKKLEPSG-IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441
               GLG+++ G  G   +   G + +K + K  A E  G I+ GD+I+A++G  L G  +
Sbjct: 2756 TSAGLGLSLDG--GKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMH 2813

Query: 442  QQAVEVLRHTGQTVLLTLMRR 462
              A  +++   +  +  L+R+
Sbjct: 2814 FDAWNIMKSVPEGPVQLLIRK 2834



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 64/230 (27%), Positives = 103/230 (44%), Gaps = 30/230 (13%)

Query: 135 VEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQ 194
           + +  L K    GLGFS+ G R   RG++GIFV+ I     A  DGRLKE D+IL +NG 
Sbjct: 584 ISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGI 643

Query: 195 ALDQTITHQQAISILQKAKD-----TVQLVIARGSLPQLVSPI-VSRSPS---------- 238
            + + +T Q+AI   ++ +      TV+  +   SL    +P  +SRS S          
Sbjct: 644 PI-KGLTFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGAS 702

Query: 239 ------AASTISAHSNPVHWQHMETIELVNDGSGLGFGI------IGGKATGVIVKTILP 286
                  +S+      P     +     +N    +G GI      +     G+ + ++ P
Sbjct: 703 AGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAP 762

Query: 287 GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC-GNRVKLMIAR 335
           G VA     L  GD IL++   ++   +  +V  +L +C    V+L+I R
Sbjct: 763 GSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGR 812



 Score = 70.9 bits (172), Expect = 1e-11
 Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 2/122 (1%)

Query: 1920 DVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSP 1979
            D  + T + +   S        +S  + ++++G  +   + L +  DGLG  + GG GS 
Sbjct: 298  DAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVG--RIWKMELLKESDGLGIQVSGGRGSK 355

Query: 1980 HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
                 I V  V   GAA  DGRL  GD+++ +NG  L G++HEEAVAIL+   G V L+V
Sbjct: 356  RSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVV 415

Query: 2040 LS 2041
             S
Sbjct: 416  AS 417



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 53/180 (29%), Positives = 81/180 (45%), Gaps = 36/180 (20%)

Query: 1634 KGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEA 1693
            K  +GLG S+ GG+D    +I +H V+ +GAA ++G +  GD +L VNG  L    H   
Sbjct: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687

Query: 1694 INVL------------------------RQTPQRV-------RLTLYRDEAPYKEEEVCD 1722
            + VL                        RQ P          R T+  +    +   V D
Sbjct: 2688 LKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPLEPGIGRSVAVHD 2747

Query: 1723 TLTIELQKKPGKGLGLSIVGKRN----DTGVFVSDIVKGGIADADGRLMQGDQILMVNGE 1778
             L +E+ K    GLGLS+ G ++    D  + +  + KGG A+  G +  GD+IL +NG+
Sbjct: 2748 ALCVEVLKTSA-GLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGK 2806



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 55/230 (23%), Positives = 92/230 (40%), Gaps = 21/230 (9%)

Query: 1706 LTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN--DTGVFVSDIVKGGIADAD 1763
            LTL ++     E E  D   I L +K G GLG S+ G  +     + V  +   G A  +
Sbjct: 2604 LTLIQEAKAQSENEE-DVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQE 2662

Query: 1764 GRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNA 1823
            G + +GD +L VNG  +       V  +L  ++    +      G              A
Sbjct: 2663 GTMNRGDFLLSVNGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTA 2722

Query: 1824 LASEIQGLRTVEMKKG-----------------PTDSLGISIAGGVGSPLGDVPIFIAMM 1866
                +   +T+ ++ G                  +  LG+S+ GG  S  GD P+ I  +
Sbjct: 2723 NGKGLLSRKTIPLEPGIGRSVAVHDALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRV 2782

Query: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEMQV 1915
            +  G A Q   +  GD I+ I G    G+ H  A N++K+   G +++ +
Sbjct: 2783 YKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQLLI 2832



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 53/221 (23%), Positives = 100/221 (45%), Gaps = 18/221 (8%)

Query: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVP 636
           F++++ P G     G+L  GDE+L+VNGI + G   Q+ ++  K++   + ++  R    
Sbjct: 615 FVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVR---- 670

Query: 637 PTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEA 696
             T+    SL  C    +   H+        + +       +D G S+   +      + 
Sbjct: 671 --TKLVSPSLTPC----STPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDR 724

Query: 697 GIQHIELEKGSK---GLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMF 753
            +  + L K  +   G+G   L     ++ +   I I SL PG +A+ +  L  GD+++ 
Sbjct: 725 IVMEVTLNKEPRVGLGIGACCL----ALENSPPGIYIHSLAPGSVAKMESNLSRGDQILE 780

Query: 754 VNDVNLENSSLEEAVEALKGAPSGTVRIGVAK-PLPLSPEE 793
           VN VN+ +++L +    L   P G VR+ + + P P   E+
Sbjct: 781 VNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQ 821



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 54/192 (28%), Positives = 93/192 (48%), Gaps = 16/192 (8%)

Query: 1355 KGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNA 1414
            K  SGLG S+AG  D    S+ +  +   GAA ++G +   D LL +NG  L G +H N 
Sbjct: 2628 KEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687

Query: 1415 SSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET---EPTVTTSDA 1471
              ++  A      + +  K         P    EP  +N + L +++T   EP +  S A
Sbjct: 2688 LKVLHQAQLHKDALVVIKKGMDQPR---PSARQEPPTANGKGLLSRKTIPLEPGIGRSVA 2744

Query: 1472 AVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSG---VIIKSLTEHGVAATDGRLKVGD 1527
              D         +E+ K   GLG+++   + +++G   ++IK + + G A   G ++ GD
Sbjct: 2745 VHDALC------VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGD 2798

Query: 1528 QILAVDDEIVVG 1539
            +ILA++ + +VG
Sbjct: 2799 EILAINGKPLVG 2810



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 72/278 (25%), Positives = 130/278 (46%), Gaps = 40/278 (14%)

Query: 1436 VNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQG-GLG 1494
            ++Q+ V  G+  + L S   ++ +K T  T+   +A     + ++V  + L + +G GLG
Sbjct: 2577 LDQLLVSAGDQ-QRLQSVLSSVGSKSTILTLI-QEAKAQSENEEDVCFIVLNRKEGSGLG 2634

Query: 1495 IAISEEDTLSGVIIKSLTEH-----GVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLL 1549
             +++     + V  KS+T H     G A+ +G +  GD +L+V+   + G      + +L
Sbjct: 2635 FSVAGG---TDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVL 2691

Query: 1550 KTAKMTVKLTIHAENPDSQAVPSAAG---AASGEKKNSSQSLMVPQSGSPEPESIRNTSR 1606
              A++     +  +    Q  PSA      A+G+   S +++ +      EP   R+   
Sbjct: 2692 HQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPL------EPGIGRSV-- 2743

Query: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLG--AIIIHEVYEEGA 1664
                   A   A C         +E+ K   GLGLS+ GG  ++ G   ++I  VY+ GA
Sbjct: 2744 -------AVHDALC---------VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGA 2787

Query: 1665 ACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ 1702
            A + G + AGD+IL +NG  L    H +A N+++  P+
Sbjct: 2788 AEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPE 2825



 Score = 61.2 bits (147), Expect = 1e-08
 Identities = 43/157 (27%), Positives = 77/157 (49%), Gaps = 5/157 (3%)

Query: 371 EESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
           E    + +EL K   GLGI ++G  G K+  P  I V  + +  A   DGR+ +GD+++ 
Sbjct: 328 EVGRIWKMELLKESDGLGIQVSGGRGSKR-SPHAIVVTQVKEGGAAHRDGRLSLGDELLV 386

Query: 431 VDGTNLQGFTNQQAVEVLRH-TGQTVLLTLMRRGMKQE-AELMSREDVTKDADLSPVNAS 488
           ++G  L G ++++AV +LR  TG   L+   +    ++   L S+      + +  V++ 
Sbjct: 387 INGHLLVGLSHEEAVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSW 446

Query: 489 IIKENYEKD--EDFLSSTRNTNILPTEEEGYPLLSAE 523
              E+ E D  ED  +S+     +P  +E   +  AE
Sbjct: 447 TDNEDQEADGEEDEGTSSSVQRAMPGTDEPQDVCGAE 483



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 69/284 (24%), Positives = 115/284 (40%), Gaps = 55/284 (19%)

Query: 1486 LPKDQG-GLGIAISE-EDTLSG---VIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY 1540
            L K++G GLG +I+   D + G   + +K++  +G AA DGRLK GD+IL V+   + G 
Sbjct: 589  LYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGL 648

Query: 1541 PIEK------------FISLLKTAKMTVKLT-----IHAENPDSQAVPSAAGAASGEKKN 1583
              ++            F+  ++T  ++  LT      H     S    ++ GA++G    
Sbjct: 649  TFQEAIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDE 708

Query: 1584 SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSI 1643
             S S +  ++  P+   +   + +  P +     A C         + +     G     
Sbjct: 709  GSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLGIGACC---------LALENSPPG----- 754

Query: 1644 VGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ- 1702
                      I IH +     A  +  L  GDQILEVN +++R A   +   +L + P  
Sbjct: 755  ----------IYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPG 804

Query: 1703 RVRLTLYRDEAPYKEEEVCDTL--------TIELQKKPGKGLGL 1738
             VRL + R   P   E+  D +        + E    PG G  L
Sbjct: 805  PVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPL 848



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 67/282 (23%), Positives = 111/282 (39%), Gaps = 61/282 (21%)

Query: 350  TLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKS 409
            ++ S  T    ++   +  + EE   F V   K   GLG ++AG      +EP  I V  
Sbjct: 2596 SVGSKSTILTLIQEAKAQSENEEDVCFIVLNRKEGSGLGFSVAG---GTDVEPKSITVHR 2652

Query: 410  ITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQ--TVLLTLMRRGMKQE 467
            +    A   +G +  GD +++V+G +L G  +   ++VL H  Q     L ++++GM Q 
Sbjct: 2653 VFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNVLKVL-HQAQLHKDALVVIKKGMDQP 2711

Query: 468  AELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEI 527
                 +E                                    P    G  LLS +   +
Sbjct: 2712 RPSARQE------------------------------------PPTANGKGLLSRKTIPL 2735

Query: 528  EDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATV------GHHFIRSV 581
            E    +  A+           ++ +   V K S  +GLG+SL+         G   I+ V
Sbjct: 2736 EPGIGRSVAV-----------HDALCVEVLKTS--AGLGLSLDGGKSSVTGDGPLVIKRV 2782

Query: 582  LPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELP 623
               G    +G + +GDE+L +NG  L+G  H D  NI+K +P
Sbjct: 2783 YKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVP 2824



 Score = 58.5 bits (140), Expect = 6e-08
 Identities = 37/122 (30%), Positives = 60/122 (49%), Gaps = 8/122 (6%)

Query: 258 IELVNDGSGLGFGIIGGKAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAG 312
           +EL+ +  GLG  + GG+ +      ++V  +  GG A + GRL  GD +L I    L G
Sbjct: 335 MELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVG 394

Query: 313 MSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEE 372
           +S E+   +LR     V+L++A    +E +A   L +T  S P  T  +   +S    E+
Sbjct: 395 LSHEEAVAILRSATGMVQLVVAS---KENSAEDLLRLTSKSLPDLTSSVEDVSSWTDNED 451

Query: 373 SE 374
            E
Sbjct: 452 QE 453



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 40/127 (31%), Positives = 64/127 (50%), Gaps = 9/127 (7%)

Query: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHI---ELEKGSKGLGFSILDYQDPIDP 723
           S+  E  ++  +    ST +V++P  +    +  I     EKG KGLGFSI   +D I  
Sbjct: 552 SASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEKG-KGLGFSIAGGRDCIR- 609

Query: 724 ASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSG----TV 779
               I ++++ P G A +DGRL  GD ++ VN + ++  + +EA+   K   SG    TV
Sbjct: 610 GQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669

Query: 780 RIGVAKP 786
           R  +  P
Sbjct: 670 RTKLVSP 676



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 58/244 (23%), Positives = 91/244 (37%), Gaps = 31/244 (12%)

Query: 548  NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVN 603
            N E V   V    E SGLG S+            +  V  +G     G +  GD LL VN
Sbjct: 2616 NEEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVN 2675

Query: 604  GITLLGENHQDVVNILKELPI--EVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDL 661
            G +L G  H +V+ +L +  +  +  +V  +    P   +  +        L  +  + L
Sbjct: 2676 GASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPSARQEPPTANGKGLLSRKTIPL 2735

Query: 662  GEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPI 721
               IG S      L                         +E+ K S GLG S LD     
Sbjct: 2736 EPGIGRSVAVHDALC------------------------VEVLKTSAGLGLS-LDGGKSS 2770

Query: 722  DPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRI 781
                  ++I+ +  GG AE+ G +  GD ++ +N   L      +A   +K  P G V++
Sbjct: 2771 VTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2830

Query: 782  GVAK 785
             + K
Sbjct: 2831 LIRK 2834



 Score = 47.8 bits (112), Expect = 1e-04
 Identities = 44/137 (32%), Positives = 65/137 (47%), Gaps = 9/137 (6%)

Query: 655 EKPHVDLGEFIGSSETEDPVLAMTD------AGQSTEEVQAPLAMWEAG-IQHIELEKGS 707
           E+  VD G      +T+ P+    D       G++  +    LA  E G I  +EL K S
Sbjct: 282 ERSEVDRGTEHRIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKES 341

Query: 708 KGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEA 767
            GLG  +   +     +   I++  +  GG A +DGRL  GD L+ +N   L   S EEA
Sbjct: 342 DGLGIQVSGGRGS-KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEA 400

Query: 768 VEALKGAPSGTVRIGVA 784
           V  L+ A +G V++ VA
Sbjct: 401 VAILRSA-TGMVQLVVA 416



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 47/164 (28%), Positives = 76/164 (46%), Gaps = 18/164 (10%)

Query: 1081 GPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQN 1140
            GPD  +  V   HLE  ++  G +  R+   D   + T  D     +R   +G +++ Q+
Sbjct: 269  GPD-SLKEVAGPHLERSEVDRGTEH-RIPKTDAPLT-TSND-----KRRFSKGGKTDFQS 320

Query: 1141 T---AYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAG 1197
            +   A     +  ++EL +E S  LGI + GGRG      +      I +  V E   A 
Sbjct: 321  SDCLAREEVGRIWKMELLKE-SDGLGIQVSGGRG------SKRSPHAIVVTQVKEGGAAH 373

Query: 1198 KNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQS 1241
            ++G L  GD ++ ++G  L   SHE+AV  +R A   V  +V S
Sbjct: 374  RDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVAS 417



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 48/171 (28%), Positives = 70/171 (40%), Gaps = 25/171 (14%)

Query: 561 ENSGLGISLEATVG-----HHFIRSVLPEGPVGH-SGKLFSGDELLEVNGITLLGENHQD 614
           E+ GLGI +    G     H  + + + EG   H  G+L  GDELL +NG  L+G +H++
Sbjct: 340 ESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEE 399

Query: 615 VVNIL-------------KELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDL 661
            V IL             KE   E  +    +++P  T S  D     D    E    D 
Sbjct: 400 AVAILRSATGMVQLVVASKENSAEDLLRLTSKSLPDLTSSVEDVSSWTD---NEDQEADG 456

Query: 662 GEFIGSSETEDPVLAMTDAGQ---STEEVQAPLAMWEAGIQHIELEKGSKG 709
            E  G+S +    +  TD  Q     EE +  L   + G   I+L+    G
Sbjct: 457 EEDEGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSG 507



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 30/83 (36%), Positives = 44/83 (53%), Gaps = 2/83 (2%)

Query: 1351 IELEKGHSGLGLSLAGNKDRSRMS--VFIVGIDPNGAAGKDGRLQIADELLEINGQILYG 1408
            +E+ K  +GLGLSL G K        + I  +   GAA + G ++  DE+L ING+ L G
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810

Query: 1409 RSHQNASSIIKCAPSKVKIIFIR 1431
              H +A +I+K  P     + IR
Sbjct: 2811 LMHFDAWNIMKSVPEGPVQLLIR 2833



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 29/85 (34%), Positives = 50/85 (58%), Gaps = 3/85 (3%)

Query: 139  ELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
            E+LK  S GLG S+ G +S   G+  + ++ + +G  A + G ++  D+ILAING+ L  
Sbjct: 2752 EVLKT-SAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL-V 2809

Query: 199  TITHQQAISILQKAKD-TVQLVIAR 222
             + H  A +I++   +  VQL+I +
Sbjct: 2810 GLMHFDAWNIMKSVPEGPVQLLIRK 2834



 Score = 36.2 bits (82), Expect = 0.34
 Identities = 14/41 (34%), Positives = 26/41 (63%)

Query: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
            +++  +  N  AGK G++++ DE+L +NGQ++ G     AS
Sbjct: 119  IWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVSGAS 159



 Score = 35.0 bits (79), Expect = 0.75
 Identities = 22/100 (22%), Positives = 45/100 (45%), Gaps = 10/100 (10%)

Query: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
            + L R+    LG S+ GG  +  +         I +  V     A + GT+  GD ++ V
Sbjct: 2623 IVLNRKEGSGLGFSVAGGTDVEPK--------SITVHRVFSQGAASQEGTMNRGDFLLSV 2674

Query: 1212 DGMDLRDASHEQAVEAIRKA--GNPVVFMVQSIINRPRKS 1249
            +G  L   +H   ++ + +A      + +++  +++PR S
Sbjct: 2675 NGASLAGLAHGNVLKVLHQAQLHKDALVVIKKGMDQPRPS 2714



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
            + + K ++ LG+++   K  +     ++++ +  GGA  + G I  GD IL+IN +  + 
Sbjct: 2751 VEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVG 2810

Query: 1065 VTNAQA 1070
            + +  A
Sbjct: 2811 LMHFDA 2816


>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
          Length = 1076

 Score =  123 bits (309), Expect = 2e-27
 Identities = 145/627 (23%), Positives = 270/627 (43%), Gaps = 92/627 (14%)

Query: 1351 IELEKGHSGLGLSLAG----NKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
            + L K  +  G  + G    ++++SR  V I  + P G A ++G ++  D LL ++G  L
Sbjct: 153  VTLHKEGNTFGFVIRGGAHDDRNKSR-PVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211

Query: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466
             G +H  A SI+K    +  ++   +   ++ +A   G  +                   
Sbjct: 212  LGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLL------------------- 252

Query: 1467 TTSDAAVDLSSFKNVQHLELPKDQGG-LGIAISEEDTLSG--VIIKSLTEHGVAATDGRL 1523
                             +E+ K  G  LG+A++     +   ++I  +    +A   G L
Sbjct: 253  -----------------VEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGAL 295

Query: 1524 KVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI--------HAENPDSQAVPSAAG 1575
             VGD IL++D   +    + +    L      VKL I          + PD  A+ S++ 
Sbjct: 296  HVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSF 355

Query: 1576 AASGEKKNSSQSL---MVPQS-------GSPEPESIRNTSRSSTPAIFASDPATCPIIPG 1625
            + +     S  SL    +P+S       G+     ++     S+ ++ +S       +  
Sbjct: 356  SPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVH 415

Query: 1626 CETT--IEISKGRTGLGLSIVGG---SDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEV 1680
             ETT  +  +   TG G+ + G    ++TL    +I  +  +  A + G L  GD+++ +
Sbjct: 416  TETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAI 475

Query: 1681 NGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV--CDTLTIELQKKPGKGLGL 1738
            NGI    +T +EA  +LR +    ++TL   E    E  +    T  ++L KK    LG+
Sbjct: 476  NGIPTEDSTFEEASQLLRDSSITSKVTL-EIEFDVAESVIPSSGTFHVKLPKKHNVELGI 534

Query: 1739 SIVG---KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
            +I     ++    + +SDI KG +A   G L  GD++L ++   + N + E    +L+  
Sbjct: 535  TISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQC 594

Query: 1796 EGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK--GPTDSLGISIAGGVG 1853
            E  +      L      ++ +      A+      + TVE+K+  GP   LGI+I+G   
Sbjct: 595  EDLVK-----LKIRKDEDNSDEQESSGAI------IYTVELKRYGGP---LGITISG-TE 639

Query: 1854 SPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEM 1913
             P    PI I+ +   G+A +T  + +GDRI+ I  +S +G   ++A++LL+ A  ++ +
Sbjct: 640  EPFD--PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTL 697

Query: 1914 QVVAGGDVSVVTGHQQEPASSSLSFTG 1940
            ++    D    +  ++ P SS LS  G
Sbjct: 698  KIKKQTDAQSASSPKKFPISSHLSDLG 724



 Score =  117 bits (292), Expect = 2e-25
 Identities = 159/724 (21%), Positives = 289/724 (39%), Gaps = 150/724 (20%)

Query: 137 VFELLKPPSGGLGFSVVG-LRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQA 195
           V EL+K     LG +V G +  + +      V  +++G +A R  +L   D I A+NG  
Sbjct: 53  VVELMKKEGTTLGLTVSGGIDKDGKPR----VSNLRQGGIAARSDQLDVGDYIKAVNGIN 108

Query: 196 LDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHM 255
           L +   H + IS+L+   + V L +     P                +S   + V ++ +
Sbjct: 109 LAK-FRHDEIISLLKNVGERVVLEVEYELPP----------------VSVQGSSVIFRTV 151

Query: 256 ETIELVNDGSGLGFGIIGG------KATGVIVKTILPGGVADQHGRLCSGDHILKIGDTD 309
           E + L  +G+  GF I GG      K+  V++  + PGG AD+ G +  GD +L +    
Sbjct: 152 E-VTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIR 210

Query: 310 LAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQK 369
           L G +  +   +L+QCG    L+I                 + S  T++  L V+ +   
Sbjct: 211 LLGTTHAEAMSILKQCGQEAALLIEYDV-----------SVMDSVATASGPLLVEVAKTP 259

Query: 370 GEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
           G                LG+ +   +   K     I +  I  +S  +  G + +GD I+
Sbjct: 260 G--------------ASLGVALTTSMCCNK---QVIVIDKIKSASIADRCGALHVGDHIL 302

Query: 430 AVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489
           ++DGT+++  T  +A + L +T   V L ++                T+ A   P +A++
Sbjct: 303 SIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ------------TRLALKGPDHAAL 350

Query: 490 IKENYEKD--EDFLSSTRNTNILP-----TEEEGYPLLSAEIEEIEDAQKQEAALLTKWQ 542
           +  ++       +  S+ N   LP     T   G  ++   ++     +K   + L+   
Sbjct: 351 VSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRG-TMMRRRLK-----KKDFKSSLSLAS 404

Query: 543 RIMGINYEIVVAHVSKF----SENSGLGISLEATV-------GHHFIRSVLPEGPVGHSG 591
             +G+  ++V    ++        +G GI L+ +V           I  +  + P    G
Sbjct: 405 STVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCG 464

Query: 592 KLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDI 651
            L  GD ++ +NGI       ++   +L++    +T            +S + S     +
Sbjct: 465 VLQIGDRVMAINGIPTEDSTFEEASQLLRD--SSITSKVTLEIEFDVAESVIPSSGTFHV 522

Query: 652 ELTEKPHVDLGEFI--------------------------GSSETEDPVLA--------- 676
           +L +K +V+LG  I                          G+ E  D +LA         
Sbjct: 523 KLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC 582

Query: 677 -MTDAGQSTEEVQAPLAM--------------WEAGIQHIELEKGSKGLGFSILDYQDPI 721
            M DA Q  ++ +  + +                A I  +EL++    LG +I   ++P 
Sbjct: 583 SMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPF 642

Query: 722 DPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRI 781
           DP    III SL  GG+AE+ G +  GDR++ +N  +L+   L EA+  L+ A   TV +
Sbjct: 643 DP----IIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMA-GETVTL 697

Query: 782 GVAK 785
            + K
Sbjct: 698 KIKK 701



 Score =  103 bits (257), Expect = 2e-21
 Identities = 151/631 (23%), Positives = 245/631 (38%), Gaps = 145/631 (22%)

Query: 1478 FKNVQHLELPKDQGG-LGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDE 1535
            FK    +EL K +G  LG+ +S      G   + +L + G+AA   +L VGD I AV+  
Sbjct: 48   FKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGI 107

Query: 1536 IVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGS 1595
             +  +  ++ ISLLK     V L +  E P                              
Sbjct: 108  NLAKFRHDEIISLLKNVGERVVLEVEYELP------------------------------ 137

Query: 1596 PEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTG--LGLSIVGGSD---TL 1650
              P S++ +S      IF               T+E++  + G   G  I GG+      
Sbjct: 138  --PVSVQGSS-----VIF--------------RTVEVTLHKEGNTFGFVIRGGAHDDRNK 176

Query: 1651 LGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYR 1710
               ++I  V   G A ++G +  GD++L V+GI L   TH EA+++L+Q  Q   L +  
Sbjct: 177  SRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEY 236

Query: 1711 DEAPYKEEEVCD-TLTIELQKKPGKGLGLSIVGKR--NDTGVFVSDIVKGGIADADGRLM 1767
            D +           L +E+ K PG  LG+++      N   + +  I    IAD  G L 
Sbjct: 237  DVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALH 296

Query: 1768 QGDQILMVNGEDVR------------NATQEAVAALL----------------------- 1792
             GD IL ++G  +             N T +    +L                       
Sbjct: 297  VGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFS 356

Query: 1793 --KVSEGSLSSF---TFPLSGSSTS----------------ESLESSSKKNALASEIQGL 1831
               +S  SLSS    T P S  STS                 SL  +S    LA ++   
Sbjct: 357  PTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHT 416

Query: 1832 RTVE--MKKGPTDSLGISIAGGV-GSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTIC 1888
             T E  +   P    GI + G V  +     P  I+ +     A +   L++GDR++ I 
Sbjct: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAIN 476

Query: 1889 GTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQ 1948
            G  TE  T  +A  LL+++S + ++ +    DV+                + + SS  F 
Sbjct: 477  GIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAE---------------SVIPSSGTFH 521

Query: 1949 DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQI 2008
              L  P+  ++        LG +I        GD P+ +  +     A   G L+ GD++
Sbjct: 522  VKL--PKKHNVE-------LGITISSPSSRKPGD-PLVISDIKKGSVAHRTGTLELGDKL 571

Query: 2009 IAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            +A++   L+  + E+AV IL++ +  V L +
Sbjct: 572  LAIDNIRLDNCSMEDAVQILQQCEDLVKLKI 602



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 150/758 (19%), Positives = 290/758 (38%), Gaps = 138/758 (18%)

Query: 1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEV 1211
            VEL ++   +LG+++ GG     +     + +G           A ++  L  GD I  V
Sbjct: 54   VELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQG---------GIAARSDQLDVGDYIKAV 104

Query: 1212 DGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFA 1271
            +G++L    H++ +  ++  G  VV  V+  +  P      S++            N F 
Sbjct: 105  NGINLAKFRHDEIISLLKNVGERVVLEVEYEL-PPVSVQGSSVIFRTVEVTLHKEGNTF- 162

Query: 1272 DSLQINADKAPSQSESEPEKAPLCSVPPPPPS----------------AFAEMGSDHTQ- 1314
                I       +++S P    +  V P  P+                    +G+ H + 
Sbjct: 163  -GFVIRGGAHDDRNKSRP--VVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEA 219

Query: 1315 -SSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRM 1373
             S   +  Q+     E+  S   + +   T +G L +   +   + LG++L  +   ++ 
Sbjct: 220  MSILKQCGQEAALLIEYDVS---VMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQ 276

Query: 1374 SVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFI--- 1430
             + I  I     A + G L + D +L I+G  +   +   A+  +     +VK+  +   
Sbjct: 277  VIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHH 336

Query: 1431 ---------------------RNKDAVNQMAVCPGNAVEPLPSNS-------ENLQNKET 1462
                                  +  A +  ++  G     L S S         L+ K+ 
Sbjct: 337  QTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDF 396

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPK------DQGGLGIAI-----SEEDTLSGVIIKSL 1511
            + +++ + + V L+    V H E  +         G GI +     + E   S  +I  +
Sbjct: 397  KSSLSLASSTVGLAG--QVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYI 454

Query: 1512 TEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVP 1571
                 A   G L++GD+++A++         E+   LL+ + +T K+T+  E   +++V 
Sbjct: 455  EADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESV- 513

Query: 1572 SAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIE 1631
                              +P SG         T     P                     
Sbjct: 514  ------------------IPSSG---------TFHVKLP--------------------- 525

Query: 1632 ISKGRTGLGLSIVGGSDTLLG-AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATH 1690
              K    LG++I   S    G  ++I ++ +   A + G L  GD++L ++ I L   + 
Sbjct: 526  -KKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSM 584

Query: 1691 DEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTL--TIELQKKPGKGLGLSIVGKRND-T 1747
            ++A+ +L+Q    V+L + +DE    E+E    +  T+EL K+ G  LG++I G      
Sbjct: 585  EDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVEL-KRYGGPLGITISGTEEPFD 643

Query: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807
             + +S + KGG+A+  G +  GD+IL +N   ++         LL+++     + T  + 
Sbjct: 644  PIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAG---ETVTLKIK 700

Query: 1808 GSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLG 1845
              + ++S  SS KK  ++S +  L  VE    P    G
Sbjct: 701  KQTDAQS-ASSPKKFPISSHLSDLGDVEEDSSPAQKPG 737



 Score = 80.1 bits (196), Expect = 2e-14
 Identities = 58/221 (26%), Positives = 107/221 (48%), Gaps = 27/221 (12%)

Query: 1820 KKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
            ++ ++  E +G   VE+ K    +LG++++GG+     D    ++ +   G+AA++ +L 
Sbjct: 40   RRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGIDK---DGKPRVSNLRQGGIAARSDQLD 96

Query: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFT 1939
            VGD I  + G +     H + ++LLKN    + ++V           ++  P S      
Sbjct: 97   VGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVE----------YELPPVSVQ---- 142

Query: 1940 GLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGG-YGSPHGDLPIYVKTVFAKGAASE 1998
               SS IF+          +TL +  +  GF I GG +   +   P+ +  V   G A  
Sbjct: 143  --GSSVIFRT-------VEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADR 193

Query: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            +G +K GD++++V+G  L G TH EA++ILK+      L++
Sbjct: 194  EGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLI 234



 Score = 75.5 bits (184), Expect = 5e-13
 Identities = 146/707 (20%), Positives = 265/707 (37%), Gaps = 152/707 (21%)

Query: 120 DEFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVV---------------------GLRSE 158
           DE   L+KN+ +   +EV E   PP    G SV+                     G   +
Sbjct: 115 DEIISLLKNVGERVVLEV-EYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDD 173

Query: 159 NRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISILQKAKDTVQL 218
                 + +  ++ G  A R+G +K  D++L+++G  L  T TH +A+SIL++      L
Sbjct: 174 RNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGT-THAEAMSILKQCGQEAAL 232

Query: 219 VIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATG 278
           +I                 S   +++  S P+  +  +T      G+ LG  +       
Sbjct: 233 LI-------------EYDVSVMDSVATASGPLLVEVAKT-----PGASLGVALTTSMCCN 274

Query: 279 ---VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIA- 334
              +++  I    +AD+ G L  GDHIL I  T +   +  +  Q L    ++VKL I  
Sbjct: 275 KQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILP 334

Query: 335 -------------RGAIEERTAPTAL-GITLSSSPTSTPELRVDASTQKGE--------- 371
                           +    +PT++   +LSS    T    + +++ +G          
Sbjct: 335 HHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKK 394

Query: 372 --------------------ESETFDVELTKN-VQGLGITIAGYIGDKKLEPSGIFVKSI 410
                                +ET +V LT + V G GI + G +   +   S   +  I
Sbjct: 395 DFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYI 454

Query: 411 TKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAEL 470
              S  E  G +QIGD+++A++G   +  T ++A ++LR +  T  +TL       E E 
Sbjct: 455 EADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTL-------EIEF 507

Query: 471 MSREDVTKDADLSPV----------NASIIKENYEKDED--FLSSTRNTNI---LPTEEE 515
              E V   +    V            +I   +  K  D   +S  +  ++     T E 
Sbjct: 508 DVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLEL 567

Query: 516 GYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSG----------- 564
           G  LL+ +   +++   ++A       +I+    ++V   + K  +NS            
Sbjct: 568 GDKLLAIDNIRLDNCSMEDAV------QILQQCEDLVKLKIRKDEDNSDEQESSGAIIYT 621

Query: 565 ---------LGISLEAT---VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENH 612
                    LGI++  T        I S+   G    +G +  GD +L +N  +L G+  
Sbjct: 622 VELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPL 681

Query: 613 QDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHV-DLGEFIGSSETE 671
            + +++L+     VT+   ++T   +  S          +     H+ DLG+    S   
Sbjct: 682 SEAIHLLQMAGETVTLKIKKQTDAQSASSPK--------KFPISSHLSDLGDVEEDSSPA 733

Query: 672 DPVLAMTDAGQST-EEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
                ++D   ST   V + +  W+     I+   G++G  F    Y
Sbjct: 734 QKPGKLSDMYPSTVPSVDSAVDSWDGSA--IDTSYGTQGTSFQASGY 778



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 99/365 (27%), Positives = 153/365 (41%), Gaps = 53/365 (14%)

Query: 1685 LRKATHDEAI---NVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIV 1741
            LR+ T DE+    +  +  P    L + R   P   EE   +  +EL KK G  LGL++ 
Sbjct: 13   LRRLTKDESPYTKSASQTKPPDGALAVRRQSIP---EEFKGSTVVELMKKEGTTLGLTVS 69

Query: 1742 GKRNDTG-VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK-VSEGSL 1799
            G  +  G   VS++ +GGIA    +L  GD I  VNG ++     + + +LLK V E  +
Sbjct: 70   GGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVV 129

Query: 1800 SSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEM---KKGPTDSLGISIAGGVGSPL 1856
                + L   S   S           S I   RTVE+   K+G T   G  I GG     
Sbjct: 130  LEVEYELPPVSVQGS-----------SVI--FRTVEVTLHKEGNT--FGFVIRGGAHDDR 174

Query: 1857 G-DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQV 1915
                P+ I  + P G A +   ++ GDR++++ G    G TH +A+++LK      E  +
Sbjct: 175  NKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQ--EAAL 232

Query: 1916 VAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGG 1975
            +   DVSV+       A++S                GP     + + + P G    +   
Sbjct: 233  LIEYDVSVM----DSVATAS----------------GP---LLVEVAKTP-GASLGVALT 268

Query: 1976 YGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTV 2035
                     I +  + +   A   G L  GD I++++G S+E  T  EA   L  T   V
Sbjct: 269  TSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQV 328

Query: 2036 TLMVL 2040
             L +L
Sbjct: 329  KLEIL 333



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 78/323 (24%), Positives = 139/323 (43%), Gaps = 45/323 (13%)

Query: 1722 DTLTIELQKKPGKGLGLSIVGKRNDTGVF-----VSDIVKGGIADADGRLMQGDQILMVN 1776
            +T  + L   P  G G+ + G    T        +S I     A+  G L  GD+++ +N
Sbjct: 417  ETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAIN 476

Query: 1777 GEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEM 1836
            G    ++T E  + LL+  + S++S          +ES+  SS          G   V++
Sbjct: 477  GIPTEDSTFEEASQLLR--DSSITSKVTLEIEFDVAESVIPSS----------GTFHVKL 524

Query: 1837 KKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMT 1896
             K     LGI+I+       GD P+ I+ +    VA +T  L +GD+++ I     +  +
Sbjct: 525  PKKHNVELGITISSPSSRKPGD-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCS 583

Query: 1897 HTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQC 1956
               AV +L+     +++++    D S      ++ +S ++ +T                 
Sbjct: 584  MEDAVQILQQCEDLVKLKIRKDEDNS-----DEQESSGAIIYT----------------- 621

Query: 1957 KSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSL 2016
              + L+R    LG +I  G   P    PI + ++   G A   G +  GD+I+A+N  SL
Sbjct: 622  --VELKRYGGPLGITI-SGTEEPFD--PIIISSLTKGGLAERTGAIHIGDRILAINSSSL 676

Query: 2017 EGVTHEEAVAILKRTKGTVTLMV 2039
            +G    EA+ +L+    TVTL +
Sbjct: 677  KGKPLSEAIHLLQMAGETVTLKI 699



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 137/620 (22%), Positives = 237/620 (38%), Gaps = 120/620 (19%)

Query: 107  GPGIPHINGKPACD----EFDQLIKNMAQGRHV------EVFELLKPPSGG--------- 147
            G  +  ING P  D    E  QL+++ +    V      +V E + P SG          
Sbjct: 469  GDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKH 528

Query: 148  ---LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204
               LG ++    S   G+  + + +I++GSVAHR G L+  D++LAI+   LD   + + 
Sbjct: 529  NVELGITISSPSSRKPGD-PLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNC-SMED 586

Query: 205  AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264
            A+ ILQ+ +D V+L I              R     S     S  + +    T+EL   G
Sbjct: 587  AVQILQQCEDLVKLKI--------------RKDEDNSDEQESSGAIIY----TVELKRYG 628

Query: 265  SGLGFGIIGGKAT--GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVL 322
              LG  I G +     +I+ ++  GG+A++ G +  GD IL I  + L G    +   +L
Sbjct: 629  GPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 688

Query: 323  RQCGNRVKLMIAR----------------------GAIEERTAPTALGITLSSS-PTSTP 359
            +  G  V L I +                      G +EE ++P      LS   P++ P
Sbjct: 689  QMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVP 748

Query: 360  ELRVDASTQKGEESETFDVELTKNVQGLGITIAGY---IGDKKLEPSGIFVKSITKSSAV 416
               VD++    + S    ++ +   QG     +GY     D +       +  +TK  + 
Sbjct: 749  S--VDSAVDSWDGSA---IDTSYGTQGTSFQASGYNFNTYDWRSPKQRGSLSPVTKPRSQ 803

Query: 417  EHDGRIQIGDQIIAVDGTNLQGFTN--------------QQAVEVLRHTGQTVLLTLMR- 461
             +     +G      D +   GF                 QA+E L   GQ+ +L  +  
Sbjct: 804  TYP---DVGLSYEDWDRSTASGFAGAADSAETEQEENFWSQALEDLETCGQSGILRELEE 860

Query: 462  --------RGMKQEAELMSREDVTKDADL----SPVNASIIKENYEKDEDFLSSTRNTNI 509
                    R M   A +MS   ++ + +     S +      +         S T  +N 
Sbjct: 861  KADRRVSLRNMTLLATIMSGSTMSLNHEAPTPRSQLGRQASFQERSSSRPHYSQTTRSNT 920

Query: 510  LPTEEEGYPLLSAEI-EEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGIS 568
            LP++     +   ++ +EI++        L K           V  +     E+ G  ++
Sbjct: 921  LPSDVGRKSVTLRKMKQEIKEIMSPTPVELHK-----------VTLYKDSDMEDFGFSVA 969

Query: 569  LEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTM 628
                    +++++ P GP G  G L   D LL+VN +     +   VV ++ E   ++ +
Sbjct: 970  DGLLEKGVYVKNIRPAGP-GDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESGNKLDL 1028

Query: 629  VCCRRTVPPTTQSELDSLDL 648
            V  R   P  +Q  +D   L
Sbjct: 1029 VISRN--PLASQKSIDQQSL 1046



 Score = 65.9 bits (159), Expect = 4e-10
 Identities = 71/297 (23%), Positives = 127/297 (42%), Gaps = 43/297 (14%)

Query: 1318 SKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFI 1377
            S I+  V  E EF     ++ E     +G  H+   +K +  LG++++    R      +
Sbjct: 495  SSITSKVTLEIEF-----DVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLV 549

Query: 1378 VG-IDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
            +  I     A + G L++ D+LL I+   L   S ++A  I++     VK+   +++D  
Sbjct: 550  ISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDED-- 607

Query: 1437 NQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIA 1496
                            NS+  +                 SS   +  +EL +  G LGI 
Sbjct: 608  ----------------NSDEQE-----------------SSGAIIYTVELKRYGGPLGIT 634

Query: 1497 IS-EEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT 1555
            IS  E+    +II SLT+ G+A   G + +GD+ILA++   + G P+ + I LL+ A  T
Sbjct: 635  ISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGET 694

Query: 1556 VKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAI 1612
            V L I  +  D+Q+  S          +    +    S + +P  + +   S+ P++
Sbjct: 695  VTLKIKKQT-DAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSV 750



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 102/478 (21%), Positives = 187/478 (39%), Gaps = 63/478 (13%)

Query: 350 TLSSSPTSTPE--LRVDASTQKGEESETFDVELTKNV-QGLGITIAGYIGDKKLEPSGIF 406
           T S+S T  P+  L V   +   E   +  VEL K     LG+T++G I DK  +P    
Sbjct: 24  TKSASQTKPPDGALAVRRQSIPEEFKGSTVVELMKKEGTTLGLTVSGGI-DKDGKPR--- 79

Query: 407 VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLL----TLMRR 462
           V ++ +        ++ +GD I AV+G NL  F + + + +L++ G+ V+L     L   
Sbjct: 80  VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139

Query: 463 GMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILP--------TEE 514
            ++  + +    +VT   +       +I+     D +       T + P        T +
Sbjct: 140 SVQGSSVIFRTVEVTLHKE-GNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIK 198

Query: 515 EGYPLLS-----------AEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA------HVS 557
            G  LLS           AE   I     QEAALL ++   + +   +  A       V+
Sbjct: 199 PGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYD--VSVMDSVATASGPLLVEVA 256

Query: 558 KFSENSGLGISLEATVGHH----FIRSVLPEGPVGHSGKLFSGDELLEVNGITL----LG 609
           K +  + LG++L  ++  +     I  +         G L  GD +L ++G ++    L 
Sbjct: 257 K-TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLA 315

Query: 610 ENHQDVVNILKELPIEVTMVCCRRTV---PPTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
           E  Q + N   ++ +E+      R     P        S     +       +++G    
Sbjct: 316 EATQFLANTTDQVKLEILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPR 375

Query: 667 SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGI----QHIELEKGS--------KGLGFSI 714
           S  +  P   M       ++ ++ L++  + +    Q +  E            G G  +
Sbjct: 376 SLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQL 435

Query: 715 LDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
                  +  S+  +I  +     AE+ G L  GDR+M +N +  E+S+ EEA + L+
Sbjct: 436 QGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493



 Score = 41.6 bits (96), Expect = 0.008
 Identities = 57/272 (20%), Positives = 112/272 (41%), Gaps = 32/272 (11%)

Query: 984  EQSSLACNAECVMLQNVSKESFERTINIAKG-NSSLG--MTVSANKDGLGMIVRSIIHGG 1040
            ++++L    +  ++ +V+  S    + +AK   +SLG  +T S   +   +++  I    
Sbjct: 228  QEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSAS 287

Query: 1041 AISRDGRIAIGDCILSINEESTISVTNAQARAMLR----------------RHSLIGPD- 1083
               R G + +GD ILSI+  S    T A+A   L                 R +L GPD 
Sbjct: 288  IADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLALKGPDH 347

Query: 1084 ---IKITYVPAEHLEEFKIS---LGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESE 1137
               +  ++ P   +  + +S   +G     + +     +   R + +   +       S 
Sbjct: 348  AALVSSSFSPTS-MSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASST 406

Query: 1138 LQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAG 1197
            +         +   V L  +P    GI + G       LS+  +     I ++  DSPA 
Sbjct: 407  VGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPL-----ISYIEADSPAE 461

Query: 1198 KNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
            + G L+ GDR++ ++G+   D++ E+A + +R
Sbjct: 462  RCGVLQIGDRVMAINGIPTEDSTFEEASQLLR 493



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 20/55 (36%), Positives = 31/55 (56%), Gaps = 1/55 (1%)

Query: 1008 TINIAKGNSSLGMTVSANKDGLG-MIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
            T+ + +    LG+T+S  ++    +I+ S+  GG   R G I IGD IL+IN  S
Sbjct: 621  TVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSS 675



 Score = 35.4 bits (80), Expect = 0.57
 Identities = 19/67 (28%), Positives = 39/67 (58%), Gaps = 1/67 (1%)

Query: 1173 GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAG 1232
            G  +++G + +G+++K++    P G  G LKP DR+++V+ +  RD      V  I ++G
Sbjct: 965  GFSVADGLLEKGVYVKNIRPAGP-GDLGGLKPYDRLLQVNHVRTRDFDCCLVVPLIAESG 1023

Query: 1233 NPVVFMV 1239
            N +  ++
Sbjct: 1024 NKLDLVI 1030


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score =  122 bits (306), Expect = 4e-27
 Identities = 115/400 (28%), Positives = 172/400 (43%), Gaps = 92/400 (23%)

Query: 1699 QTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN------DTGVFVS 1752
            Q  Q   + +   E  Y+ EE+    T+E   +   GLG SI G  +      D G+F++
Sbjct: 27   QAMQHAFIPVNGTEIEYEFEEI----TLE---RGNSGLGFSIAGGTDNPHIGDDPGIFIT 79

Query: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTS 1812
             I+ GG A  DGRL   D IL VN  DV              SE S S     L  + + 
Sbjct: 80   KIIPGGAAAEDGRLRVNDCILRVNEVDV--------------SEVSHSKAVEALKEAGSI 125

Query: 1813 ESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL--GDVPIFIAMMHPTG 1870
              L    ++  L + ++    +++ KGP   LG SIAGGVG+    GD  I++  +   G
Sbjct: 126  VRLYVRRRRPILETVVE----IKLFKGPK-GLGFSIAGGVGNQHIPGDNSIYVTKIIDGG 180

Query: 1871 VAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQV--------------- 1915
             A +  +L+VGDR++ +   S E +TH +AV +LKN S  + ++V               
Sbjct: 181  AAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPP 240

Query: 1916 -------------VAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL----------- 1951
                         +  G+   +      P  S   ++ +    +  DD            
Sbjct: 241  DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300

Query: 1952 -------------GPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998
                         G P  + + L +G  GLGF+IVGG         I+V  + A G A  
Sbjct: 301  QPSMTLQRAVSLEGEP--RKVVLHKGSTGLGFNIVGGEDGE----GIFVSFILAGGPADL 354

Query: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLM 2038
             G L+RGDQI++VNG  L G +HE+A A LK    TVT++
Sbjct: 355  SGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394



 Score =  115 bits (288), Expect = 4e-25
 Identities = 80/210 (38%), Positives = 109/210 (51%), Gaps = 36/210 (17%)

Query: 1834 VEMKKGPTDSLGISIAGGVGSP-LGDVP-IFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891
            + +++G    LG SIAGG  +P +GD P IFI  + P G AA+  +LRV D I+ +    
Sbjct: 48   ITLERG-NSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVD 106

Query: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL 1951
               ++H++AV  LK A   + + V            ++ P   ++               
Sbjct: 107  VSEVSHSKAVEALKEAGSIVRLYV-----------RRRRPILETVV-------------- 141

Query: 1952 GPPQCKSITLERGPDGLGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRLKRGDQII 2009
                   I L +GP GLGFSI GG G+ H  GD  IYV  +   GAA +DGRL+ GD+++
Sbjct: 142  ------EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLL 195

Query: 2010 AVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
             VN  SLE VTHEEAVAILK T   V L V
Sbjct: 196  MVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225



 Score =  114 bits (286), Expect = 7e-25
 Identities = 100/396 (25%), Positives = 176/396 (44%), Gaps = 69/396 (17%)

Query: 256 ETIELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDT 308
           E I L    SGLGF I GG          G+ +  I+PGG A + GRL   D IL++ + 
Sbjct: 46  EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105

Query: 309 DLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQ 368
           D++ +S  +  + L++ G+ V+L + R                       P L       
Sbjct: 106 DVSEVSHSKAVEALKEAGSIVRLYVRR---------------------RRPILET----- 139

Query: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQ 427
                   +++L K  +GLG +IAG +G++ +   + I+V  I    A + DGR+Q+GD+
Sbjct: 140 ------VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDR 193

Query: 428 IIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNA 487
           ++ V+  +L+  T+++AV +L++T + V L + +       +     D+T      P+  
Sbjct: 194 LLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYS-PPMEN 252

Query: 488 SIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIED---------AQKQEAALL 538
            ++  N    E        T++ P     Y  +   +   +D         A +Q +  L
Sbjct: 253 HLLSGNNGTLE------YKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTL 306

Query: 539 TKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVLPEGPVGHSGKL 593
            +   + G   ++V+        ++GLG ++   VG       F+  +L  GP   SG+L
Sbjct: 307 QRAVSLEGEPRKVVL-----HKGSTGLGFNI---VGGEDGEGIFVSFILAGGPADLSGEL 358

Query: 594 FSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629
             GD++L VNGI L G +H+     LK     VT++
Sbjct: 359 QRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTII 394



 Score =  111 bits (277), Expect = 8e-24
 Identities = 109/388 (28%), Positives = 162/388 (41%), Gaps = 66/388 (17%)

Query: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMS----VFIVGIDPNGAAGKDGRLQIADELLEIN 1402
            E   I LE+G+SGLG S+AG  D   +     +FI  I P GAA +DGRL++ D +L +N
Sbjct: 44   EFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVN 103

Query: 1403 GQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKET 1462
               +   SH  A   +K A S V++   R +  +                          
Sbjct: 104  EVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPIL-------------------------- 137

Query: 1463 EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGR 1522
                   +  V++  FK  + L      GG+G      D  + + +  + + G A  DGR
Sbjct: 138  -------ETVVEIKLFKGPKGLGF-SIAGGVGNQHIPGD--NSIYVTKIIDGGAAQKDGR 187

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKL------TIHAENP-------DSQA 1569
            L+VGD++L V++  +     E+ +++LK     V L      TI+  +P        S +
Sbjct: 188  LQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYS 247

Query: 1570 VPSAAGAASGEKKNSSQSLMVPQSG----SPEPESIR----NTSRSSTPAIFASDPATCP 1621
             P      SG          +P       SP P+ +      TS S           T  
Sbjct: 248  PPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQ 307

Query: 1622 ---IIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678
                + G    + + KG TGLG +IVGG D     I +  +   G A   G L  GDQIL
Sbjct: 308  RAVSLEGEPRKVVLHKGSTGLGFNIVGGEDG--EGIFVSFILAGGPADLSGELQRGDQIL 365

Query: 1679 EVNGIDLRKATHDEAINVLRQTPQRVRL 1706
             VNGIDLR A+H++A   L+   Q V +
Sbjct: 366  SVNGIDLRGASHEQAAAALKGAGQTVTI 393



 Score =  109 bits (272), Expect = 3e-23
 Identities = 106/428 (24%), Positives = 175/428 (40%), Gaps = 89/428 (20%)

Query: 1009 INIAKGNSSLGMTVSANKDGL------GMIVRSIIHGGAISRDGRIAIGDCILSINEEST 1062
            I + +GNS LG +++   D        G+ +  II GGA + DGR+ + DCIL +NE   
Sbjct: 48   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107

Query: 1063 ISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDI 1122
              V++++A   L+                            ++G ++ L     Y  R  
Sbjct: 108  SEVSHSKAVEALK----------------------------EAGSIVRL-----YVRRRR 134

Query: 1123 PELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVM 1182
            P L    E                     ++L++ P K LG SI GG  +G++   G+  
Sbjct: 135  PILETVVE---------------------IKLFKGP-KGLGFSIAGG--VGNQHIPGD-- 168

Query: 1183 RGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSI 1242
              I++  +++   A K+G L+ GDR++ V+   L + +HE+AV  ++     V   V   
Sbjct: 169  NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKP 228

Query: 1243 INRPRKSPL--PSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPP 1300
                   P   P + H+  P        P  + L    +       S P  +P    P P
Sbjct: 229  TTIYMTDPYGPPDITHSYSP--------PMENHLLSGNNGTLEYKTSLPPISPGRYSPIP 280

Query: 1301 PPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGL 1360
                  +  + H+Q S +     +  +            R  +L GE   + L KG +GL
Sbjct: 281  KHMLVDDDYTSHSQHSTATRQPSMTLQ------------RAVSLEGEPRKVVLHKGSTGL 328

Query: 1361 GLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKC 1420
            G ++ G +D     +F+  I   G A   G LQ  D++L +NG  L G SH+ A++ +K 
Sbjct: 329  GFNIVGGEDGE--GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386

Query: 1421 APSKVKII 1428
            A   V II
Sbjct: 387  AGQTVTII 394



 Score =  100 bits (250), Expect = 1e-20
 Identities = 68/174 (39%), Positives = 94/174 (54%), Gaps = 16/174 (9%)

Query: 1630 IEISKGRTGLGLSIVGGSDTL-LG---AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
            I + +G +GLG SI GG+D   +G    I I ++   GAA +DGRL   D IL VN +D+
Sbjct: 48   ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107

Query: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGK-- 1743
             + +H +A+  L++    VRL + R   P  E  V     I+L K P KGLG SI G   
Sbjct: 108  SEVSHSKAVEALKEAGSIVRLYVRR-RRPILETVV----EIKLFKGP-KGLGFSIAGGVG 161

Query: 1744 ----RNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
                  D  ++V+ I+ GG A  DGRL  GD++LMVN   +   T E   A+LK
Sbjct: 162  NQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILK 215



 Score = 98.2 bits (243), Expect = 7e-20
 Identities = 96/375 (25%), Positives = 152/375 (40%), Gaps = 89/375 (23%)

Query: 141 LKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQ 198
           L+  + GLGFS+ G         + GIF+ +I  G  A  DGRL+  D IL +N   + +
Sbjct: 50  LERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSE 109

Query: 199 TITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETI 258
            ++H +A+  L++A   V+L + R            R P   + +              I
Sbjct: 110 -VSHSKAVEALKEAGSIVRLYVRR------------RRPILETVVE-------------I 143

Query: 259 ELVNDGSGLGFGIIGGKAT-------GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLA 311
           +L     GLGF I GG           + V  I+ GG A + GRL  GD +L + +  L 
Sbjct: 144 KLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLE 203

Query: 312 GMSSEQVAQVLRQCGNRVKLMIAR--------------------------------GAIE 339
            ++ E+   +L+     V L + +                                G +E
Sbjct: 204 EVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLE 263

Query: 340 ERTA--PTALG---------------ITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382
            +T+  P + G                + S   T+T +  +        E E   V L K
Sbjct: 264 YKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHK 323

Query: 383 NVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQ 442
              GLG  I G  G+   +  GIFV  I      +  G +Q GDQI++V+G +L+G +++
Sbjct: 324 GSTGLGFNIVG--GE---DGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHE 378

Query: 443 QAVEVLRHTGQTVLL 457
           QA   L+  GQTV +
Sbjct: 379 QAAAALKGAGQTVTI 393



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 85/273 (31%), Positives = 124/273 (45%), Gaps = 60/273 (21%)

Query: 1009 INIAKGNSSLGMTVSANKDGLG---------MIVRSIIHGGAISRDGRIAIGDCILSINE 1059
            I + KG   LG +++    G+G         + V  II GGA  +DGR+ +GD +L +N 
Sbjct: 143  IKLFKGPKGLGFSIAG---GVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199

Query: 1060 ESTISVTNAQARAMLRRHSLI------------------GPDIKITYVPA--EHLE---- 1095
             S   VT+ +A A+L+  S +                   PDI  +Y P    HL     
Sbjct: 200  YSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 259

Query: 1096 ---EFKISL-----GQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWN 1147
               E+K SL     G+ S     + +   YT        +      + S     A S   
Sbjct: 260  GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHS-----QHSTATRQPSMTLQRAVSLEG 314

Query: 1148 QPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDR 1207
            +PR+V L  + S  LG +IVGG        +GE   GIF+  +L   PA  +G L+ GD+
Sbjct: 315  EPRKVVL-HKGSTGLGFNIVGGE-------DGE---GIFVSFILAGGPADLSGELQRGDQ 363

Query: 1208 IVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQ 1240
            I+ V+G+DLR ASHEQA  A++ AG  V  + Q
Sbjct: 364  ILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQ 396



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 71/253 (28%), Positives = 106/253 (41%), Gaps = 61/253 (24%)

Query: 139 ELLKPPSGGLGFSVVGLRSENR--GELGIFVQEIQEGSVAHRDGRLKETDQILAINGQAL 196
           +L K P G LGFS+ G        G+  I+V +I +G  A +DGRL+  D++L +N  +L
Sbjct: 144 KLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202

Query: 197 DQTITHQQAISILQKAKDTVQLVIARGSLPQLVSP------------------------- 231
           ++ +TH++A++IL+   + V L + + +   +  P                         
Sbjct: 203 EE-VTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGT 261

Query: 232 ------IVSRSPSAASTISAH-----SNPVHWQHMET--------------------IEL 260
                 +   SP   S I  H         H QH                       + L
Sbjct: 262 LEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 321

Query: 261 VNDGSGLGFGIIGGK-ATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVA 319
               +GLGF I+GG+   G+ V  IL GG AD  G L  GD IL +   DL G S EQ A
Sbjct: 322 HKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAA 381

Query: 320 QVLRQCGNRVKLM 332
             L+  G  V ++
Sbjct: 382 AALKGAGQTVTII 394



 Score = 81.3 bits (199), Expect = 9e-15
 Identities = 111/397 (27%), Positives = 169/397 (42%), Gaps = 69/397 (17%)

Query: 695  EAGIQHIELEKGSKGLGFSILDYQD-PIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMF 753
            E   + I LE+G+ GLGFSI    D P       I I  ++PGG A +DGRL   D ++ 
Sbjct: 42   EYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILR 101

Query: 754  VNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEA 813
            VN+V++   S  +AVEALK A S  VR+ V +  P+   E  V  K              
Sbjct: 102  VNEVDVSEVSHSKAVEALKEAGS-IVRLYVRRRRPIL--ETVVEIK-------------- 144

Query: 814  GLADKPLFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDG-LN 872
                  LF+    L G + A  V      + + P ++SIY T+   +   G++  DG L 
Sbjct: 145  ------LFKGPKGL-GFSIAGGVG-----NQHIPGDNSIYVTK---IIDGGAAQKDGRLQ 189

Query: 873  YGSSLPSSPPKDVIENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMG-PASGFTI 931
             G  L               ++  + SLEE+  +  +      +  V + +G P + +  
Sbjct: 190  VGDRL---------------LMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMT 234

Query: 932  NDYTPANAIEQQYECENTIVWTESHLPSEVISSAE----LPSVLPDSAGKGSEYLL---- 983
            + Y P + I   Y         E+HL S    + E    LP + P       +++L    
Sbjct: 235  DPYGPPD-ITHSYSPP-----MENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDD 288

Query: 984  ----EQSSLACNAECVMLQN-VSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIH 1038
                 Q S A     + LQ  VS E   R + + KG++ LG  +   +DG G+ V  I+ 
Sbjct: 289  YTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILA 348

Query: 1039 GGAISRDGRIAIGDCILSINEESTISVTNAQARAMLR 1075
            GG     G +  GD ILS+N       ++ QA A L+
Sbjct: 349  GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALK 385



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 85/303 (28%), Positives = 130/303 (42%), Gaps = 61/303 (20%)

Query: 1624 PGCETTIEIS--KGRTGLGLSIVGG--SDTLLG--AIIIHEVYEEGAACKDGRLWAGDQI 1677
            P  ET +EI   KG  GLG SI GG  +  + G  +I + ++ + GAA KDGRL  GD++
Sbjct: 135  PILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194

Query: 1678 LEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLG 1737
            L VN   L + TH+EA+ +L+ T + V L            +V    TI +    G    
Sbjct: 195  LMVNNYSLEEVTHEEAVAILKNTSEVVYL------------KVGKPTTIYMTDPYGP--- 239

Query: 1738 LSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEG 1797
                           DI        +  L+ G+           N T E   +L  +S G
Sbjct: 240  --------------PDITHSYSPPMENHLLSGN-----------NGTLEYKTSLPPISPG 274

Query: 1798 SLSSFTFPL---------SGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISI 1848
              S     +         S  ST+    S + + A++ E +  R V + KG T  LG +I
Sbjct: 275  RYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEP-RKVVLHKGST-GLGFNI 332

Query: 1849 AGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS 1908
             GG         IF++ +   G A  + +L+ GD+I+++ G    G +H QA   LK A 
Sbjct: 333  VGGEDGE----GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAG 388

Query: 1909 GSI 1911
             ++
Sbjct: 389  QTV 391



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 41/85 (48%), Positives = 52/85 (61%), Gaps = 2/85 (2%)

Query: 1957 KSITLERGPDGLGFSIVGGYGSPH-GDLP-IYVKTVFAKGAASEDGRLKRGDQIIAVNGQ 2014
            + ITLERG  GLGFSI GG  +PH GD P I++  +   GAA+EDGRL+  D I+ VN  
Sbjct: 46   EEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEV 105

Query: 2015 SLEGVTHEEAVAILKRTKGTVTLMV 2039
             +  V+H +AV  LK     V L V
Sbjct: 106  DVSEVSHSKAVEALKEAGSIVRLYV 130



 Score = 69.7 bits (169), Expect = 3e-11
 Identities = 67/269 (24%), Positives = 109/269 (40%), Gaps = 44/269 (16%)

Query: 553 VAHVSKFSENSGLGISLEATVGHH--------FIRSVLPEGPVGHSGKLFSGDELLEVNG 604
           V  +  F    GLG S+   VG+         ++  ++  G     G+L  GD LL VN 
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199

Query: 605 ITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEF 664
            +L    H++ V ILK      + V   +   PTT    D     DI  +  P ++    
Sbjct: 200 YSLEEVTHEEAVAILKN----TSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLL 255

Query: 665 IGSSETEDPVLAM---------------------TDAGQSTEEVQAPLAMWEAGI----- 698
            G++ T +   ++                     T   Q +   + P    +  +     
Sbjct: 256 SGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGE 315

Query: 699 -QHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
            + + L KGS GLGF+I+  +D        I +  ++ GG A+  G L  GD+++ VN +
Sbjct: 316 PRKVVLHKGSTGLGFNIVGGED-----GEGIFVSFILAGGPADLSGELQRGDQILSVNGI 370

Query: 758 NLENSSLEEAVEALKGAPSGTVRIGVAKP 786
           +L  +S E+A  ALKGA      I   +P
Sbjct: 371 DLRGASHEQAAAALKGAGQTVTIIAQYQP 399



 Score = 67.8 bits (164), Expect = 1e-10
 Identities = 60/174 (34%), Positives = 80/174 (45%), Gaps = 33/174 (18%)

Query: 654 TEKPHV--DLGEFI-----GSSETEDPVLAMTDAGQSTEEV--------QAPLAMWEAG- 697
           T+ PH+  D G FI     G +  ED  L + D      EV        +A  A+ EAG 
Sbjct: 65  TDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGS 124

Query: 698 ---------------IQHIELEKGSKGLGFSILD-YQDPIDPASTVIIIRSLVPGGIAEK 741
                          +  I+L KG KGLGFSI     +   P    I +  ++ GG A+K
Sbjct: 125 IVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQK 184

Query: 742 DGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPLPLSPEEGY 795
           DGRL  GDRL+ VN+ +LE  + EEAV  LK   S  V + V KP  +   + Y
Sbjct: 185 DGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNT-SEVVYLKVGKPTTIYMTDPY 237



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 67/262 (25%), Positives = 107/262 (40%), Gaps = 49/262 (18%)

Query: 1351 IELEKGHSGLGLSLAGNKDRSRM----SVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
            I+L KG  GLG S+AG      +    S+++  I   GAA KDGRLQ+ D LL +N   L
Sbjct: 143  IKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSL 202

Query: 1407 YGRSHQNASSIIKCAPSKVKIIFIR-NKDAVNQM-----------AVCPGNAVEPLPSNS 1454
               +H+ A +I+K   +  ++++++  K     M           +  P      L  N+
Sbjct: 203  EEVTHEEAVAILK---NTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNN 259

Query: 1455 ENLQNKETEPTVTTSDAA-------VDLSSFKNVQH-----------------------L 1484
              L+ K + P ++    +       VD     + QH                       +
Sbjct: 260  GTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKV 319

Query: 1485 ELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEK 1544
             L K   GLG  I   +   G+ +  +   G A   G L+ GDQIL+V+   + G   E+
Sbjct: 320  VLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQ 379

Query: 1545 FISLLKTAKMTVKLTIHAENPD 1566
              + LK A  TV +    +  D
Sbjct: 380  AAAALKGAGQTVTIIAQYQPED 401



 Score = 51.6 bits (122), Expect = 8e-06
 Identities = 32/96 (33%), Positives = 50/96 (52%), Gaps = 9/96 (9%)

Query: 372 ESETFDVELTKNVQGLGITIAG-----YIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGD 426
           E E  ++ L +   GLG +IAG     +IGD      GIF+  I    A   DGR+++ D
Sbjct: 42  EYEFEEITLERGNSGLGFSIAGGTDNPHIGDDP----GIFITKIIPGGAAAEDGRLRVND 97

Query: 427 QIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRR 462
            I+ V+  ++   ++ +AVE L+  G  V L + RR
Sbjct: 98  CILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRR 133


>gi|218505835 membrane-associated guanylate kinase-related  3 isoform
            1 [Homo sapiens]
          Length = 1481

 Score =  122 bits (305), Expect = 5e-27
 Identities = 175/740 (23%), Positives = 296/740 (40%), Gaps = 93/740 (12%)

Query: 1010 NIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNA 1068
            ++ K     G T+   ++    + V++++  G  ++DG+IA GD I+ IN    +  T+A
Sbjct: 412  SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471

Query: 1069 QARAMLRR---HSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPEL 1125
                M +    +  +   +   Y   +  E+  + +   +  +    +    T  +  + 
Sbjct: 472  DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDF 531

Query: 1126 -PEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGIS---------IVGGRGMGSR 1175
             P     E              N P      R    S G S         I G +G G  
Sbjct: 532  KPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFA 591

Query: 1176 LSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPV 1235
            +++     G  +K +L+         L+ GD I E+   ++++ +H Q VE +++   PV
Sbjct: 592  IADSPT--GQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQVVEVLKQF--PV 644

Query: 1236 VFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLC 1295
               V  +I R    P P+                   + ++  DK  +    E    P+ 
Sbjct: 645  GADVPLLILRGGP-PSPT------------------KTAKMKTDKKENAGSLEAINEPIP 685

Query: 1296 SVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEK 1355
               P PPS          +S + K+        E     K + E     T +L +  L K
Sbjct: 686  QPMPFPPSII--------RSGSPKLDPS-----EVYLKSKTLYEDKPPNTKDLDVF-LRK 731

Query: 1356 GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
              SG G  + G  D    S++I  I P GAA KDGRL+ ADEL+ I+G  + G+SH+   
Sbjct: 732  QESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790

Query: 1416 SIIKCAPSKVKIIF-IRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
             ++  A     ++  +R K       +  G       S+   +  +   P +  ++    
Sbjct: 791  DLMTTAARNGHVLLTVRRK-------IFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPAR 843

Query: 1475 LSSFKNVQHLELPKDQGGLGIAI--SEEDTLSGVI---IKSLTEHGVAATDGRLKVGDQI 1529
             +  +    +   K+  G G  I  S+     GVI   I  + E   A   G+LKVGD I
Sbjct: 844  PAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHI 903

Query: 1530 LAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAA------SGEKKN 1583
             AV+ + +V    +  + L+K A +TV LT+ AE  +    PS   +A            
Sbjct: 904  SAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE-EHHGPPSGTNSARQSPALQHRPMG 962

Query: 1584 SSQSLMVP--------QSGSPEPESIRNTSRSSTPAIFASDPATCPIIP-------GCET 1628
             SQ+  +P        + G     S R+ S S    +   D A   ++        GC  
Sbjct: 963  QSQANHIPGDRSALEGEIGKDVSTSYRH-SWSDHKHLAQPDTAVISVVGSRHNQNLGCYP 1021

Query: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688
             +E+ +G  G G S+ GG +  +G  I+  + E+G A KDGR+  GDQI+E+NG   +  
Sbjct: 1022 -VELERGPRGFGFSLRGGKEYNMGLFILR-LAEDGPAIKDGRIHVGDQIVEINGEPTQGI 1079

Query: 1689 THDEAINVLRQTPQRVRLTL 1708
            TH  AI +++    +V L L
Sbjct: 1080 THTRAIELIQAGGNKVLLLL 1099



 Score = 99.4 bits (246), Expect = 3e-20
 Identities = 155/747 (20%), Positives = 290/747 (38%), Gaps = 158/747 (21%)

Query: 1344 LTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            L G L    L+K   G G ++ G  DR    + +  +  +G A +DG++   D +++ING
Sbjct: 404  LKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462

Query: 1404 QILYGRSHQNASSIIKCAP------------------SKVKII-FIRNKDAVNQMAVCPG 1444
              + G +H +   + +  P                  S+  ++  +     +N  ++  G
Sbjct: 463  NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522

Query: 1445 ----NAVEPLPSNSENLQNKETEPTVT---------TSDAAVDLSSFKNVQH--LELPKD 1489
                N  +  P      QN ++  T+T          S+  V ++S  + Q   + +P  
Sbjct: 523  ETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLI 582

Query: 1490 QGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLL 1549
            +G  G   +  D+ +G  +K + +   +     L+ GD I  +  + V      + + +L
Sbjct: 583  KGPKGFGFAIADSPTGQKVKMILD---SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639

Query: 1550 KTAKM--TVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL-----MVPQSGSPEPESIR 1602
            K   +   V L I    P S   P+       +KK ++ SL      +PQ     P  IR
Sbjct: 640  KQFPVGADVPLLILRGGPPS---PTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIR 696

Query: 1603 NTSRSSTPA-IFASDPATCPIIPGCETTIEI--SKGRTGLGLSIVGGSDTLLGAIIIHEV 1659
            + S    P+ ++          P     +++   K  +G G  ++GG D    +I I  +
Sbjct: 697  SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG-DGPDQSIYIGAI 755

Query: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL-------YRDE 1712
               GAA KDGRL A D+++ ++GI ++  +H + ++++    +   + L       Y ++
Sbjct: 756  IPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEK 815

Query: 1713 APYKEEEVC-----------------------DTLTIELQKKPGKGLGLSIVGKRN--DT 1747
             P  +                           +   + LQ+K  +G G  I+  +N    
Sbjct: 816  QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPP 875

Query: 1748 GVF---VSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTF 1804
            GV    +  +++G  AD  G+L  GD I  VNG+ +   + + +  L+K   G   + T 
Sbjct: 876  GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK-DAGVTVTLTV 934

Query: 1805 --------PLSGSST--------------SESLESSSKKNALASEI-------------- 1828
                    P SG+++              S++      ++AL  EI              
Sbjct: 935  IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSD 994

Query: 1829 ----------------------QGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMM 1866
                                   G   VE+++GP    G S+ GG    +G   +FI  +
Sbjct: 995  HKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPR-GFGFSLRGGKEYNMG---LFILRL 1050

Query: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTG 1926
               G A +  ++ VGD+IV I G  T+G+THT+A+ L++     + + +  G  +     
Sbjct: 1051 AEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLI---- 1106

Query: 1927 HQQEPASSSLSFTGLTSSSIFQDDLGP 1953
                P          +SS++  D+  P
Sbjct: 1107 ----PDHGDWDINNPSSSNVIYDEQSP 1129



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 172/766 (22%), Positives = 289/766 (37%), Gaps = 183/766 (23%)

Query: 121  EFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDG 180
            E     ++ +Q + V V   LK  + G GF+++G    +R +  + V+ + +   A +DG
Sbjct: 393  EKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIG---GDRPDEFLQVKNVLKDGPAAQDG 449

Query: 181  RLKETDQILAINGQALDQTITHQQAISILQ--KAKDTVQLVIARG-SLPQ---------- 227
            ++   D I+ ING  +    TH   + + Q       V L + RG  LP           
Sbjct: 450  KIAPGDVIVDINGNCV-LGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIV 508

Query: 228  LVSPIVS--------------------------------------RSPSAAS--TISAHS 247
              +P+++                                        PS AS   +S  S
Sbjct: 509  AATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMAS 568

Query: 248  NPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGD 307
            +      + TI L+    G GF  I    TG  VK IL          L  GD I +I  
Sbjct: 569  SGSSQPELVTIPLIKGPKGFGFA-IADSPTGQKVKMILDSQWCQ---GLQKGDIIKEIYH 624

Query: 308  TDLAGMSSEQVAQVLRQ--CGNRVKLMIARG-----------------------AIEE-- 340
             ++  ++  QV +VL+Q   G  V L+I RG                       AI E  
Sbjct: 625  QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI 684

Query: 341  -RTAPTALGITLSSSPTSTP-ELRVDAST---QKGEESETFDVELTKNVQGLGITIAGYI 395
             +  P    I  S SP   P E+ + + T    K   ++  DV L K   G G  + G  
Sbjct: 685  PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD 744

Query: 396  GDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT- 454
            G  +     I++ +I    A E DGR++  D+++ +DG  ++G +++Q ++++    +  
Sbjct: 745  GPDQ----SIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNG 800

Query: 455  -VLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTE 513
             VLLT+ R+    E +    ED +  A +S  N                           
Sbjct: 801  HVLLTVRRKIFYGEKQ---PEDDSSQAFISTQN--------------------------- 830

Query: 514  EEGYPLLS-AEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 572
              G P L+ AE+      Q+                Y++V+       EN G G  +  +
Sbjct: 831  --GSPRLNRAEVPARPAPQEP---------------YDVVLQR----KENEGFGFVILTS 869

Query: 573  -------VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE 625
                   V  H I  V+   P    GKL  GD +  VNG +++  +H ++V ++K+  + 
Sbjct: 870  KNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVT 929

Query: 626  VTMVC--------------CRRTVP-----PTTQSELDSLDLCDIELTEKPHVDLGEFIG 666
            VT+                  R  P     P  QS+ + +      L  +   D+     
Sbjct: 930  VTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYR 989

Query: 667  SSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPAST 726
             S ++   LA  D   +   V         G   +ELE+G +G GFS+   ++     + 
Sbjct: 990  HSWSDHKHLAQPDT--AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKE----YNM 1043

Query: 727  VIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
             + I  L   G A KDGR+  GD+++ +N    +  +   A+E ++
Sbjct: 1044 GLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 90/401 (22%), Positives = 161/401 (40%), Gaps = 82/401 (20%)

Query: 1707 TLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN-DTGVFVSDIVKGGIADADGR 1765
            TLY D+ P  ++     L + L+K+   G G  ++G    D  +++  I+  G A+ DGR
Sbjct: 713  TLYEDKPPNTKD-----LDVFLRKQES-GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGR 766

Query: 1766 LMQGDQILMVNGEDVRNATQEAVAALLKVS----------------------EGSLSSFT 1803
            L   D+++ ++G  V+  + + V  L+  +                      + S  +F 
Sbjct: 767  LRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFI 826

Query: 1804 FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL-GDVPIF 1862
               +GS      E  ++        Q    V +++   +  G  I      P  G +P  
Sbjct: 827  STQNGSPRLNRAEVPARPAP-----QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHK 881

Query: 1863 IAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAG---- 1918
            I  +     A +  KL+VGD I  + G S   ++H   V L+K+A  ++ + V+A     
Sbjct: 882  IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941

Query: 1919 -----------------------------GDVSVVTGHQQEPASSSLSFTGLTSSSIFQD 1949
                                         GD S + G   +  S+S   +      + Q 
Sbjct: 942  GPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQP 1001

Query: 1950 DLGPPQ-----------CKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998
            D                C  + LERGP G GFS+ GG      ++ +++  +   G A +
Sbjct: 1002 DTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG---KEYNMGLFILRLAEDGPAIK 1058

Query: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            DGR+  GDQI+ +NG+  +G+TH  A+ +++     V L++
Sbjct: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 134/611 (21%), Positives = 229/611 (37%), Gaps = 93/611 (15%)

Query: 1462 TEPTVTTSDAAVDLSSFKNVQ-HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAAT 1519
            ++P +  S    D S  K V     L K   G G  I   D     + +K++ + G AA 
Sbjct: 388  SKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ 447

Query: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT--VKLTIHAENP---DSQA----V 1570
            DG++  GD I+ ++   V+G+     + + +   +   V LT+    P   DS+     +
Sbjct: 448  DGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDI 507

Query: 1571 PSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIF--------ASDPATCPI 1622
             +A    +G+     ++ M PQ   P    +    +S              AS+      
Sbjct: 508  VAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA 567

Query: 1623 IPGCE----TTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678
              G       TI + KG  G G +I          +I+   + +G       L  GD I 
Sbjct: 568  SSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIK 620

Query: 1679 EVNGIDLRKATHDEAINVLRQTP--QRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGL 1736
            E+   +++  TH + + VL+Q P    V L + R   P   +    T  ++  KK   G 
Sbjct: 621  EIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTK----TAKMKTDKKENAGS 676

Query: 1737 GLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE 1796
              +I         F   I++ G    D                               SE
Sbjct: 677  LEAINEPIPQPMPFPPSIIRSGSPKLDP------------------------------SE 706

Query: 1797 GSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL 1856
              L S T        ++ L+   +K                       G  + GG G   
Sbjct: 707  VYLKSKTLYEDKPPNTKDLDVFLRKQE------------------SGFGFRVLGGDGP-- 746

Query: 1857 GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
             D  I+I  + P G A +  +LR  D ++ I G   +G +H Q ++L+  A+ +  + + 
Sbjct: 747  -DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLT 805

Query: 1917 AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL----GPPQCKSITLERGP-DGLGFS 1971
                +       ++ +S +   T   S  + + ++     P +   + L+R   +G GF 
Sbjct: 806  VRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFV 865

Query: 1972 IVGGYGSPH-GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKR 2030
            I+     P  G +P  +  V     A   G+LK GD I AVNGQS+  ++H+  V ++K 
Sbjct: 866  ILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD 925

Query: 2031 TKGTVTLMVLS 2041
               TVTL V++
Sbjct: 926  AGVTVTLTVIA 936



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 101/440 (22%), Positives = 176/440 (40%), Gaps = 91/440 (20%)

Query: 98   NNGNLEALTGPGIPHI---------NGKPACDEFDQLIKNMA-------QGRHVEVFELL 141
            N G+LEA+  P IP           +G P  D  +  +K+           + ++VF  L
Sbjct: 673  NAGSLEAINEP-IPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVF--L 729

Query: 142  KPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTIT 201
            +    G GF V+G    ++    I++  I     A +DGRL+  D+++ I+G  +    +
Sbjct: 730  RKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGK-S 785

Query: 202  HQQAISILQKAKDT--VQLVIARGSLPQLVSPIVSRSPSAASTISAH---------SNPV 250
            H+Q + ++  A     V L + R        P    S +  ST +           + P 
Sbjct: 786  HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845

Query: 251  HWQHMETIELVNDGSGLGFGIIGGK---ATGVI---VKTILPGGVADQHGRLCSGDHILK 304
              +  + +    +  G GF I+  K     GVI   +  ++ G  AD+ G+L  GDHI  
Sbjct: 846  PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905

Query: 305  IGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSP--------- 355
            +    +  +S + + Q+++  G  V L +   A EE   P +   +   SP         
Sbjct: 906  VNGQSIVELSHDNIVQLIKDAGVTVTLTVI--AEEEHHGPPSGTNSARQSPALQHRPMGQ 963

Query: 356  TSTPELRVDASTQKGEESET------------------------------------FDVE 379
            +    +  D S  +GE  +                                     + VE
Sbjct: 964  SQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVE 1023

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
            L +  +G G ++ G     K    G+F+  + +      DGRI +GDQI+ ++G   QG 
Sbjct: 1024 LERGPRGFGFSLRG----GKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGI 1079

Query: 440  TNQQAVEVLRHTGQTVLLTL 459
            T+ +A+E+++  G  VLL L
Sbjct: 1080 THTRAIELIQAGGNKVLLLL 1099



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 128/595 (21%), Positives = 226/595 (37%), Gaps = 106/595 (17%)

Query: 92   SFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGR---HVEVFELLKPPSGGL 148
            + +L  N  +   LTG G+   NG    D  +Q +   + G     +    L+K P G  
Sbjct: 535  AMVLEQNGKSGHTLTGDGL---NGPS--DASEQRVSMASSGSSQPELVTIPLIKGPKG-F 588

Query: 149  GFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISI 208
            GF++    +  + ++ +  Q  Q          L++ D I  I  Q + Q +TH Q + +
Sbjct: 589  GFAIADSPTGQKVKMILDSQWCQG---------LQKGDIIKEIYHQNV-QNLTHLQVVEV 638

Query: 209  LQK--AKDTVQLVIARG--------------------SLPQLVSPIVSRSPSAASTISAH 246
            L++      V L+I RG                    SL  +  PI    P   S I + 
Sbjct: 639  LKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSG 698

Query: 247  S------------------NPVHWQHMETIELVNDGSGLGFGIIGGKAT--GVIVKTILP 286
            S                   P + + ++   L    SG GF ++GG      + +  I+P
Sbjct: 699  SPKLDPSEVYLKSKTLYEDKPPNTKDLDVF-LRKQESGFGFRVLGGDGPDQSIYIGAIIP 757

Query: 287  GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG-NRVKLMIARGAI--EERTA 343
             G A++ GRL + D ++ I    + G S +QV  ++     N   L+  R  I   E+  
Sbjct: 758  LGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQP 817

Query: 344  PTALGITLSSSPTSTPELRVDASTQKGEESETFDVELT-KNVQGLGITIAGYIGDKKLEP 402
                     S+   +P L       +    E +DV L  K  +G G  I   +  K   P
Sbjct: 818  EDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVI---LTSKNKPP 874

Query: 403  SGIF---VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTL 459
             G+    +  + + S  +  G++++GD I AV+G ++   ++   V++++  G TV LT+
Sbjct: 875  PGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV 934

Query: 460  M-----------RRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTN 508
            +               +Q   L  R      A+  P + S ++    KD    +S R+  
Sbjct: 935  IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVS--TSYRH-- 990

Query: 509  ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGIS 568
                         +  +    AQ   A +     R    N  +    V       G G S
Sbjct: 991  -------------SWSDHKHLAQPDTAVISVVGSR---HNQNLGCYPVELERGPRGFGFS 1034

Query: 569  LEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
            L     ++   FI  +  +GP    G++  GD+++E+NG    G  H   + +++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 145/731 (19%), Positives = 269/731 (36%), Gaps = 89/731 (12%)

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
            L K+  G G TI G  GD+  E   + VK++ K      DG+I  GD I+ ++G  + G 
Sbjct: 413  LKKSTMGFGFTIIG--GDRPDE--FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468

Query: 440  TNQQAVEVLR--HTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPV--NASIIK-ENY 494
            T+   V++ +     Q V LTL R     +    S + V      +PV    S+ K E  
Sbjct: 469  THADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVINGQSLTKGETC 525

Query: 495  EKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA 554
               +DF             + G+ L    +    DA +Q  ++ +          E+V  
Sbjct: 526  MNPQDFKPGAMVLE--QNGKSGHTLTGDGLNGPSDASEQRVSMASSGSS----QPELVTI 579

Query: 555  HVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLF----------SGDELLEVNG 604
             + K  +  G  I+               + P G   K+            GD + E+  
Sbjct: 580  PLIKGPKGFGFAIA---------------DSPTGQKVKMILDSQWCQGLQKGDIIKEIYH 624

Query: 605  ITLLGENHQDVVNILKELPI--EVTMVCCRRTVPPTTQSELDSLDLCD----IELTEKPH 658
              +    H  VV +LK+ P+  +V ++  R   P  T++     D  +    +E   +P 
Sbjct: 625  QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI 684

Query: 659  VDLGEFIGSS-ETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
                 F  S   +  P L  ++    ++ +          +  + L K   G GF +L  
Sbjct: 685  PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD-VFLRKQESGFGFRVLGG 743

Query: 718  QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL-KGAPS 776
              P       I I +++P G AEKDGRL   D LM ++ + ++  S ++ ++ +   A +
Sbjct: 744  DGP----DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799

Query: 777  GTVRIGVAKPL---PLSPE----EGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVG 829
            G V + V + +      PE    + ++S +  S   P  +  E      P    D+ L  
Sbjct: 800  GHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGS---PRLNRAEVPARPAPQEPYDVVLQR 856

Query: 830  TNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENS 889
              +              P     +     I       CG  L  G  + +   + ++E S
Sbjct: 857  KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGK-LKVGDHISAVNGQSIVELS 915

Query: 890  CDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENT 949
             D ++ L        T  ++  ++ +        GP SG      +PA       + +  
Sbjct: 916  HDNIVQLIKDAGVTVTLTVIAEEEHH--------GPPSGTNSARQSPALQHRPMGQSQ-- 965

Query: 950  IVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFER-- 1007
                 +H+P +    + L   +         +           +  ++  V     +   
Sbjct: 966  ----ANHIPGD---RSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLG 1018

Query: 1008 --TINIAKGNSSLGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
               + + +G    G ++   K+  +G+ +  +   G   +DGRI +GD I+ IN E T  
Sbjct: 1019 CYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQG 1078

Query: 1065 VTNAQARAMLR 1075
            +T+ +A  +++
Sbjct: 1079 ITHTRAIELIQ 1089



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 75/286 (26%), Positives = 129/286 (45%), Gaps = 43/286 (15%)

Query: 1013 KGNSSLGMTV--SANKDGLGMI---VRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
            K N   G  +  S NK   G+I   +  +I G    R G++ +GD I ++N +S + +++
Sbjct: 857  KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916

Query: 1068 AQARAMLRRHSLIGPDIKITYVPAE--HLEEFKISLGQQSGRVMALDIFSSYTGRDIPEL 1125
                 +++     G  + +T +  E  H      +  +QS  +    +  S     IP  
Sbjct: 917  DNIVQLIKD---AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH-IPG- 971

Query: 1126 PEREEGEGEESELQNTAYSN-WNQPRRVELWREPSKSLGISIVGGR-------------- 1170
             +R   EGE  +  +T+Y + W+  + +    +P  ++ IS+VG R              
Sbjct: 972  -DRSALEGEIGKDVSTSYRHSWSDHKHLA---QPDTAV-ISVVGSRHNQNLGCYPVELER 1026

Query: 1171 ---GMGSRLSNG-EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVE 1226
               G G  L  G E   G+FI  + ED PA K+G +  GD+IVE++G   +  +H +A+E
Sbjct: 1027 GPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIE 1086

Query: 1227 AIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFAD 1272
             I+  GN V+ ++     RP    +P   H  +   N SS+N   D
Sbjct: 1087 LIQAGGNKVLLLL-----RPGTGLIPD--HGDWDINNPSSSNVIYD 1125



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 58/243 (23%), Positives = 99/243 (40%), Gaps = 56/243 (23%)

Query: 149  GFSVVGLRSENRGELGIFVQEIQ---EGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205
            GF  V L S+N+   G+   +I    EGS A R G+LK  D I A+NGQ++ + ++H   
Sbjct: 861  GFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVE-LSHDNI 919

Query: 206  ISILQKAKDTVQLVIAR---------GSLPQLVSPIVSRSPSAASTIS------------ 244
            + +++ A  TV L +           G+     SP +   P   S  +            
Sbjct: 920  VQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGE 979

Query: 245  -----------AHSNPVHWQHMET------------------IELVNDGSGLGFGIIGGK 275
                       + S+  H    +T                  +EL     G GF + GGK
Sbjct: 980  IGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGK 1039

Query: 276  A--TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333
                G+ +  +   G A + GR+  GD I++I      G++  +  ++++  GN+V L++
Sbjct: 1040 EYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099

Query: 334  ARG 336
              G
Sbjct: 1100 RPG 1102



 Score = 49.7 bits (117), Expect = 3e-05
 Identities = 29/78 (37%), Positives = 46/78 (58%), Gaps = 4/78 (5%)

Query: 147  GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
            G GFS+ G +  N   +G+F+  + E   A +DGR+   DQI+ ING+   Q ITH +AI
Sbjct: 1030 GFGFSLRGGKEYN---MGLFILRLAEDGPAIKDGRIHVGDQIVEINGEP-TQGITHTRAI 1085

Query: 207  SILQKAKDTVQLVIARGS 224
             ++Q   + V L++  G+
Sbjct: 1086 ELIQAGGNKVLLLLRPGT 1103



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 13/39 (33%), Positives = 24/39 (61%)

Query: 425 GDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463
           GD ++ V+GT + G TN+  + V+RH  + + L  ++ G
Sbjct: 68  GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPG 106


>gi|155969695 membrane-associated guanylate kinase-related  3 isoform
            2 [Homo sapiens]
          Length = 1125

 Score =  122 bits (305), Expect = 5e-27
 Identities = 175/740 (23%), Positives = 296/740 (40%), Gaps = 93/740 (12%)

Query: 1010 NIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTNA 1068
            ++ K     G T+   ++    + V++++  G  ++DG+IA GD I+ IN    +  T+A
Sbjct: 412  SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471

Query: 1069 QARAMLRR---HSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPEL 1125
                M +    +  +   +   Y   +  E+  + +   +  +    +    T  +  + 
Sbjct: 472  DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDF 531

Query: 1126 -PEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGIS---------IVGGRGMGSR 1175
             P     E              N P      R    S G S         I G +G G  
Sbjct: 532  KPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFA 591

Query: 1176 LSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPV 1235
            +++     G  +K +L+         L+ GD I E+   ++++ +H Q VE +++   PV
Sbjct: 592  IADSPT--GQKVKMILDSQWCQG---LQKGDIIKEIYHQNVQNLTHLQVVEVLKQF--PV 644

Query: 1236 VFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLC 1295
               V  +I R    P P+                   + ++  DK  +    E    P+ 
Sbjct: 645  GADVPLLILRGGP-PSPT------------------KTAKMKTDKKENAGSLEAINEPIP 685

Query: 1296 SVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEK 1355
               P PPS          +S + K+        E     K + E     T +L +  L K
Sbjct: 686  QPMPFPPSII--------RSGSPKLDPS-----EVYLKSKTLYEDKPPNTKDLDVF-LRK 731

Query: 1356 GHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNAS 1415
              SG G  + G  D    S++I  I P GAA KDGRL+ ADEL+ I+G  + G+SH+   
Sbjct: 732  QESGFGFRVLGG-DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790

Query: 1416 SIIKCAPSKVKIIF-IRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVD 1474
             ++  A     ++  +R K       +  G       S+   +  +   P +  ++    
Sbjct: 791  DLMTTAARNGHVLLTVRRK-------IFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPAR 843

Query: 1475 LSSFKNVQHLELPKDQGGLGIAI--SEEDTLSGVI---IKSLTEHGVAATDGRLKVGDQI 1529
             +  +    +   K+  G G  I  S+     GVI   I  + E   A   G+LKVGD I
Sbjct: 844  PAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHI 903

Query: 1530 LAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAA------SGEKKN 1583
             AV+ + +V    +  + L+K A +TV LT+ AE  +    PS   +A            
Sbjct: 904  SAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEE-EHHGPPSGTNSARQSPALQHRPMG 962

Query: 1584 SSQSLMVP--------QSGSPEPESIRNTSRSSTPAIFASDPATCPIIP-------GCET 1628
             SQ+  +P        + G     S R+ S S    +   D A   ++        GC  
Sbjct: 963  QSQANHIPGDRSALEGEIGKDVSTSYRH-SWSDHKHLAQPDTAVISVVGSRHNQNLGCYP 1021

Query: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688
             +E+ +G  G G S+ GG +  +G  I+  + E+G A KDGR+  GDQI+E+NG   +  
Sbjct: 1022 -VELERGPRGFGFSLRGGKEYNMGLFILR-LAEDGPAIKDGRIHVGDQIVEINGEPTQGI 1079

Query: 1689 THDEAINVLRQTPQRVRLTL 1708
            TH  AI +++    +V L L
Sbjct: 1080 THTRAIELIQAGGNKVLLLL 1099



 Score = 99.0 bits (245), Expect = 4e-20
 Identities = 149/705 (21%), Positives = 277/705 (39%), Gaps = 150/705 (21%)

Query: 1344 LTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            L G L    L+K   G G ++ G  DR    + +  +  +G A +DG++   D +++ING
Sbjct: 404  LKGVLVRASLKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDING 462

Query: 1404 QILYGRSHQNASSIIKCAP------------------SKVKII-FIRNKDAVNQMAVCPG 1444
              + G +H +   + +  P                  S+  ++  +     +N  ++  G
Sbjct: 463  NCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKG 522

Query: 1445 ----NAVEPLPSNSENLQNKETEPTVT---------TSDAAVDLSSFKNVQH--LELPKD 1489
                N  +  P      QN ++  T+T          S+  V ++S  + Q   + +P  
Sbjct: 523  ETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLI 582

Query: 1490 QGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLL 1549
            +G  G   +  D+ +G  +K + +   +     L+ GD I  +  + V      + + +L
Sbjct: 583  KGPKGFGFAIADSPTGQKVKMILD---SQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVL 639

Query: 1550 KTAKM--TVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSL-----MVPQSGSPEPESIR 1602
            K   +   V L I    P S   P+       +KK ++ SL      +PQ     P  IR
Sbjct: 640  KQFPVGADVPLLILRGGPPS---PTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIR 696

Query: 1603 NTSRSSTPA-IFASDPATCPIIPGCETTIEI--SKGRTGLGLSIVGGSDTLLGAIIIHEV 1659
            + S    P+ ++          P     +++   K  +G G  ++GG D    +I I  +
Sbjct: 697  SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG-DGPDQSIYIGAI 755

Query: 1660 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL-------YRDE 1712
               GAA KDGRL A D+++ ++GI ++  +H + ++++    +   + L       Y ++
Sbjct: 756  IPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEK 815

Query: 1713 APYKEEEVC-----------------------DTLTIELQKKPGKGLGLSIVGKRN--DT 1747
             P  +                           +   + LQ+K  +G G  I+  +N    
Sbjct: 816  QPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPP 875

Query: 1748 GVF---VSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTF 1804
            GV    +  +++G  AD  G+L  GD I  VNG+ +   + + +  L+K   G   + T 
Sbjct: 876  GVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK-DAGVTVTLTV 934

Query: 1805 --------PLSGSST--------------SESLESSSKKNALASEI-------------- 1828
                    P SG+++              S++      ++AL  EI              
Sbjct: 935  IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSD 994

Query: 1829 ----------------------QGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMM 1866
                                   G   VE+++GP    G S+ GG    +G   +FI  +
Sbjct: 995  HKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPR-GFGFSLRGGKEYNMG---LFILRL 1050

Query: 1867 HPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSI 1911
               G A +  ++ VGD+IV I G  T+G+THT+A+ L++     +
Sbjct: 1051 AEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKV 1095



 Score = 94.4 bits (233), Expect = 1e-18
 Identities = 177/799 (22%), Positives = 304/799 (38%), Gaps = 182/799 (22%)

Query: 121  EFDQLIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDG 180
            E     ++ +Q + V V   LK  + G GF+++G    +R +  + V+ + +   A +DG
Sbjct: 393  EKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIG---GDRPDEFLQVKNVLKDGPAAQDG 449

Query: 181  RLKETDQILAINGQALDQTITHQQAISILQ--KAKDTVQLVIARG-SLPQ---------- 227
            ++   D I+ ING  +    TH   + + Q       V L + RG  LP           
Sbjct: 450  KIAPGDVIVDINGNCV-LGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIV 508

Query: 228  LVSPIVS--------------------------------------RSPSAAST--ISAHS 247
              +P+++                                        PS AS   +S  S
Sbjct: 509  AATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMAS 568

Query: 248  NPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGD 307
            +      + TI L+    G GF I     TG  VK IL          L  GD I +I  
Sbjct: 569  SGSSQPELVTIPLIKGPKGFGFAI-ADSPTGQKVKMILDSQWCQG---LQKGDIIKEIYH 624

Query: 308  TDLAGMSSEQVAQVLRQ--CGNRVKLMIARG-----------------------AIEE-- 340
             ++  ++  QV +VL+Q   G  V L+I RG                       AI E  
Sbjct: 625  QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI 684

Query: 341  -RTAPTALGITLSSSPTSTP-ELRVDAST---QKGEESETFDVELTKNVQGLGITIAGYI 395
             +  P    I  S SP   P E+ + + T    K   ++  DV L K   G G  + G  
Sbjct: 685  PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGD 744

Query: 396  GDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT- 454
            G  +     I++ +I    A E DGR++  D+++ +DG  ++G +++Q ++++    +  
Sbjct: 745  GPDQ----SIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNG 800

Query: 455  -VLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTE 513
             VLLT+ R+    E +    ED +  A +S  N S                         
Sbjct: 801  HVLLTVRRKIFYGEKQ---PEDDSSQAFISTQNGS------------------------- 832

Query: 514  EEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT- 572
                P L+        A ++               Y++V+       EN G G  +  + 
Sbjct: 833  ----PRLNRAEVPARPAPQEP--------------YDVVLQR----KENEGFGFVILTSK 870

Query: 573  ------VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEV 626
                  V  H I  V+   P    GKL  GD +  VNG +++  +H ++V ++K+  + V
Sbjct: 871  NKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTV 930

Query: 627  TMVCCRRTV----PPTTQSELDS--LDLCDIELTEKPHV---------DLGEFIGSSE-- 669
            T+           P  T S   S  L    +  ++  H+         ++G+ + +S   
Sbjct: 931  TLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRH 990

Query: 670  --TEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTV 727
              ++   LA  D   +   V         G   +ELE+G +G GFS+   ++     +  
Sbjct: 991  SWSDHKHLAQPDT--AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKE----YNMG 1044

Query: 728  IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKPL 787
            + I  L   G A KDGR+  GD+++ +N    +  +   A+E ++ A    V + +    
Sbjct: 1045 LFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ-AGGNKVLLLLRPGT 1103

Query: 788  PLSPEEGYVSAKEDSFLYP 806
             L P+ G   +   S++ P
Sbjct: 1104 GLIPDHGLAPSGLCSYVKP 1122



 Score = 92.4 bits (228), Expect = 4e-18
 Identities = 90/401 (22%), Positives = 161/401 (40%), Gaps = 82/401 (20%)

Query: 1707 TLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN-DTGVFVSDIVKGGIADADGR 1765
            TLY D+ P  ++     L + L+K+   G G  ++G    D  +++  I+  G A+ DGR
Sbjct: 713  TLYEDKPPNTKD-----LDVFLRKQES-GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGR 766

Query: 1766 LMQGDQILMVNGEDVRNATQEAVAALLKVS----------------------EGSLSSFT 1803
            L   D+++ ++G  V+  + + V  L+  +                      + S  +F 
Sbjct: 767  LRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFI 826

Query: 1804 FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL-GDVPIF 1862
               +GS      E  ++        Q    V +++   +  G  I      P  G +P  
Sbjct: 827  STQNGSPRLNRAEVPARPAP-----QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHK 881

Query: 1863 IAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAG---- 1918
            I  +     A +  KL+VGD I  + G S   ++H   V L+K+A  ++ + V+A     
Sbjct: 882  IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHH 941

Query: 1919 -----------------------------GDVSVVTGHQQEPASSSLSFTGLTSSSIFQD 1949
                                         GD S + G   +  S+S   +      + Q 
Sbjct: 942  GPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQP 1001

Query: 1950 DLGPPQ-----------CKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998
            D                C  + LERGP G GFS+ GG      ++ +++  +   G A +
Sbjct: 1002 DTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGG---KEYNMGLFILRLAEDGPAIK 1058

Query: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
            DGR+  GDQI+ +NG+  +G+TH  A+ +++     V L++
Sbjct: 1059 DGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLL 1099



 Score = 89.0 bits (219), Expect = 4e-17
 Identities = 134/611 (21%), Positives = 229/611 (37%), Gaps = 93/611 (15%)

Query: 1462 TEPTVTTSDAAVDLSSFKNVQ-HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAAT 1519
            ++P +  S    D S  K V     L K   G G  I   D     + +K++ + G AA 
Sbjct: 388  SKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQ 447

Query: 1520 DGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMT--VKLTIHAENP---DSQA----V 1570
            DG++  GD I+ ++   V+G+     + + +   +   V LT+    P   DS+     +
Sbjct: 448  DGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDI 507

Query: 1571 PSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIF--------ASDPATCPI 1622
             +A    +G+     ++ M PQ   P    +    +S              AS+      
Sbjct: 508  VAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMA 567

Query: 1623 IPGCE----TTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQIL 1678
              G       TI + KG  G G +I          +I+   + +G       L  GD I 
Sbjct: 568  SSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQG-------LQKGDIIK 620

Query: 1679 EVNGIDLRKATHDEAINVLRQTP--QRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGL 1736
            E+   +++  TH + + VL+Q P    V L + R   P   +    T  ++  KK   G 
Sbjct: 621  EIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTK----TAKMKTDKKENAGS 676

Query: 1737 GLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSE 1796
              +I         F   I++ G    D                               SE
Sbjct: 677  LEAINEPIPQPMPFPPSIIRSGSPKLDP------------------------------SE 706

Query: 1797 GSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPL 1856
              L S T        ++ L+   +K                       G  + GG G   
Sbjct: 707  VYLKSKTLYEDKPPNTKDLDVFLRKQE------------------SGFGFRVLGGDGP-- 746

Query: 1857 GDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
             D  I+I  + P G A +  +LR  D ++ I G   +G +H Q ++L+  A+ +  + + 
Sbjct: 747  -DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLT 805

Query: 1917 AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDL----GPPQCKSITLERGP-DGLGFS 1971
                +       ++ +S +   T   S  + + ++     P +   + L+R   +G GF 
Sbjct: 806  VRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFV 865

Query: 1972 IVGGYGSPH-GDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKR 2030
            I+     P  G +P  +  V     A   G+LK GD I AVNGQS+  ++H+  V ++K 
Sbjct: 866  ILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKD 925

Query: 2031 TKGTVTLMVLS 2041
               TVTL V++
Sbjct: 926  AGVTVTLTVIA 936



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 101/440 (22%), Positives = 176/440 (40%), Gaps = 91/440 (20%)

Query: 98   NNGNLEALTGPGIPHI---------NGKPACDEFDQLIKNMA-------QGRHVEVFELL 141
            N G+LEA+  P IP           +G P  D  +  +K+           + ++VF  L
Sbjct: 673  NAGSLEAINEP-IPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVF--L 729

Query: 142  KPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTIT 201
            +    G GF V+G    ++    I++  I     A +DGRL+  D+++ I+G  +    +
Sbjct: 730  RKQESGFGFRVLGGDGPDQS---IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGK-S 785

Query: 202  HQQAISILQKAKDT--VQLVIARGSLPQLVSPIVSRSPSAASTISAH---------SNPV 250
            H+Q + ++  A     V L + R        P    S +  ST +           + P 
Sbjct: 786  HKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPA 845

Query: 251  HWQHMETIELVNDGSGLGFGIIGGK---ATGVI---VKTILPGGVADQHGRLCSGDHILK 304
              +  + +    +  G GF I+  K     GVI   +  ++ G  AD+ G+L  GDHI  
Sbjct: 846  PQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISA 905

Query: 305  IGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSP--------- 355
            +    +  +S + + Q+++  G  V L +   A EE   P +   +   SP         
Sbjct: 906  VNGQSIVELSHDNIVQLIKDAGVTVTLTVI--AEEEHHGPPSGTNSARQSPALQHRPMGQ 963

Query: 356  TSTPELRVDASTQKGEESET------------------------------------FDVE 379
            +    +  D S  +GE  +                                     + VE
Sbjct: 964  SQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVE 1023

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
            L +  +G G ++ G     K    G+F+  + +      DGRI +GDQI+ ++G   QG 
Sbjct: 1024 LERGPRGFGFSLRG----GKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGI 1079

Query: 440  TNQQAVEVLRHTGQTVLLTL 459
            T+ +A+E+++  G  VLL L
Sbjct: 1080 THTRAIELIQAGGNKVLLLL 1099



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 128/595 (21%), Positives = 226/595 (37%), Gaps = 106/595 (17%)

Query: 92   SFLLSPNNGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGR---HVEVFELLKPPSGGL 148
            + +L  N  +   LTG G+   NG    D  +Q +   + G     +    L+K P G  
Sbjct: 535  AMVLEQNGKSGHTLTGDGL---NGPS--DASEQRVSMASSGSSQPELVTIPLIKGPKG-F 588

Query: 149  GFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAISI 208
            GF++    +  + ++ +  Q  Q          L++ D I  I  Q + Q +TH Q + +
Sbjct: 589  GFAIADSPTGQKVKMILDSQWCQG---------LQKGDIIKEIYHQNV-QNLTHLQVVEV 638

Query: 209  LQK--AKDTVQLVIARG--------------------SLPQLVSPIVSRSPSAASTISAH 246
            L++      V L+I RG                    SL  +  PI    P   S I + 
Sbjct: 639  LKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSG 698

Query: 247  S------------------NPVHWQHMETIELVNDGSGLGFGIIGGKAT--GVIVKTILP 286
            S                   P + + ++   L    SG GF ++GG      + +  I+P
Sbjct: 699  SPKLDPSEVYLKSKTLYEDKPPNTKDLDVF-LRKQESGFGFRVLGGDGPDQSIYIGAIIP 757

Query: 287  GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCG-NRVKLMIARGAI--EERTA 343
             G A++ GRL + D ++ I    + G S +QV  ++     N   L+  R  I   E+  
Sbjct: 758  LGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQP 817

Query: 344  PTALGITLSSSPTSTPELRVDASTQKGEESETFDVELT-KNVQGLGITIAGYIGDKKLEP 402
                     S+   +P L       +    E +DV L  K  +G G  I   +  K   P
Sbjct: 818  EDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVI---LTSKNKPP 874

Query: 403  SGIF---VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTL 459
             G+    +  + + S  +  G++++GD I AV+G ++   ++   V++++  G TV LT+
Sbjct: 875  PGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV 934

Query: 460  M-----------RRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTN 508
            +               +Q   L  R      A+  P + S ++    KD    +S R+  
Sbjct: 935  IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVS--TSYRH-- 990

Query: 509  ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGIS 568
                         +  +    AQ   A +     R    N  +    V       G G S
Sbjct: 991  -------------SWSDHKHLAQPDTAVISVVGSR---HNQNLGCYPVELERGPRGFGFS 1034

Query: 569  LEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
            L     ++   FI  +  +GP    G++  GD+++E+NG    G  H   + +++
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 145/731 (19%), Positives = 269/731 (36%), Gaps = 89/731 (12%)

Query: 380  LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
            L K+  G G TI G  GD+  E   + VK++ K      DG+I  GD I+ ++G  + G 
Sbjct: 413  LKKSTMGFGFTIIG--GDRPDE--FLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGH 468

Query: 440  TNQQAVEVLR--HTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPV--NASIIK-ENY 494
            T+   V++ +     Q V LTL R     +    S + V      +PV    S+ K E  
Sbjct: 469  THADVVQMFQLVPVNQYVNLTLCRGYPLPDD---SEDPVVDIVAATPVINGQSLTKGETC 525

Query: 495  EKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA 554
               +DF             + G+ L    +    DA +Q  ++ +          E+V  
Sbjct: 526  MNPQDFKPGAMVLE--QNGKSGHTLTGDGLNGPSDASEQRVSMASSGSS----QPELVTI 579

Query: 555  HVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLF----------SGDELLEVNG 604
             + K  +  G  I+               + P G   K+            GD + E+  
Sbjct: 580  PLIKGPKGFGFAIA---------------DSPTGQKVKMILDSQWCQGLQKGDIIKEIYH 624

Query: 605  ITLLGENHQDVVNILKELPI--EVTMVCCRRTVPPTTQSELDSLDLCD----IELTEKPH 658
              +    H  VV +LK+ P+  +V ++  R   P  T++     D  +    +E   +P 
Sbjct: 625  QNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI 684

Query: 659  VDLGEFIGSS-ETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDY 717
                 F  S   +  P L  ++    ++ +          +  + L K   G GF +L  
Sbjct: 685  PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLD-VFLRKQESGFGFRVLGG 743

Query: 718  QDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL-KGAPS 776
              P       I I +++P G AEKDGRL   D LM ++ + ++  S ++ ++ +   A +
Sbjct: 744  DGP----DQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARN 799

Query: 777  GTVRIGVAKPL---PLSPE----EGYVSAKEDSFLYPPHSCEEAGLADKPLFRADLALVG 829
            G V + V + +      PE    + ++S +  S   P  +  E      P    D+ L  
Sbjct: 800  GHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGS---PRLNRAEVPARPAPQEPYDVVLQR 856

Query: 830  TNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENS 889
              +              P     +     I       CG  L  G  + +   + ++E S
Sbjct: 857  KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGK-LKVGDHISAVNGQSIVELS 915

Query: 890  CDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTINDYTPANAIEQQYECENT 949
             D ++ L        T  ++  ++ +        GP SG      +PA       + +  
Sbjct: 916  HDNIVQLIKDAGVTVTLTVIAEEEHH--------GPPSGTNSARQSPALQHRPMGQSQ-- 965

Query: 950  IVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFER-- 1007
                 +H+P +    + L   +         +           +  ++  V     +   
Sbjct: 966  ----ANHIPGD---RSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLG 1018

Query: 1008 --TINIAKGNSSLGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
               + + +G    G ++   K+  +G+ +  +   G   +DGRI +GD I+ IN E T  
Sbjct: 1019 CYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQG 1078

Query: 1065 VTNAQARAMLR 1075
            +T+ +A  +++
Sbjct: 1079 ITHTRAIELIQ 1089



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 74/283 (26%), Positives = 126/283 (44%), Gaps = 43/283 (15%)

Query: 1013 KGNSSLGMTV--SANKDGLGMI---VRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
            K N   G  +  S NK   G+I   +  +I G    R G++ +GD I ++N +S + +++
Sbjct: 857  KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916

Query: 1068 AQARAMLRRHSLIGPDIKITYVPAE--HLEEFKISLGQQSGRVMALDIFSSYTGRDIPEL 1125
                 +++     G  + +T +  E  H      +  +QS  +    +  S     IP  
Sbjct: 917  DNIVQLIKD---AGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANH-IPG- 971

Query: 1126 PEREEGEGEESELQNTAYSN-WNQPRRVELWREPSKSLGISIVGGR-------------- 1170
             +R   EGE  +  +T+Y + W+  + +    +P  ++ IS+VG R              
Sbjct: 972  -DRSALEGEIGKDVSTSYRHSWSDHKHLA---QPDTAV-ISVVGSRHNQNLGCYPVELER 1026

Query: 1171 ---GMGSRLSNG-EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVE 1226
               G G  L  G E   G+FI  + ED PA K+G +  GD+IVE++G   +  +H +A+E
Sbjct: 1027 GPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIE 1086

Query: 1227 AIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNP 1269
             I+  GN V+ ++     RP    +P   H L P    S   P
Sbjct: 1087 LIQAGGNKVLLLL-----RPGTGLIPD--HGLAPSGLCSYVKP 1122



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 28/94 (29%), Positives = 46/94 (48%), Gaps = 2/94 (2%)

Query: 1726 IELQKKPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNAT 1784
            +EL++ P +G G S+ G K  + G+F+  + + G A  DGR+  GDQI+ +NGE  +  T
Sbjct: 1022 VELERGP-RGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGIT 1080

Query: 1785 QEAVAALLKVSEGSLSSFTFPLSGSSTSESLESS 1818
                  L++     +     P +G      L  S
Sbjct: 1081 HTRAIELIQAGGNKVLLLLRPGTGLIPDHGLAPS 1114



 Score = 32.3 bits (72), Expect = 4.9
 Identities = 13/39 (33%), Positives = 24/39 (61%)

Query: 425 GDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRG 463
           GD ++ V+GT + G TN+  + V+RH  + + L  ++ G
Sbjct: 68  GDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPG 106


>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
          Length = 1356

 Score =  114 bits (286), Expect = 7e-25
 Identities = 113/423 (26%), Positives = 180/423 (42%), Gaps = 67/423 (15%)

Query: 1162 LGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
            LGI +V     G R        G+ +K + +   A      +  D IV ++  DLR+   
Sbjct: 284  LGIHVVPFSARGGRTL------GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRF 337

Query: 1222 EQAVEAIRKA-GNPVV-FMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINA- 1278
            EQA    R+A   P++ F V    N+ +   L     N Y    FS  + + D+  +N+ 
Sbjct: 338  EQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSA 397

Query: 1279 -----------DKAPSQSESE---PEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDV 1324
                       +  P Q +S    P  A     PP  P++  +     T SS        
Sbjct: 398  GLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSS-------- 449

Query: 1325 DKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMS--VFIVGIDP 1382
                  GY+ K I +R          I+L+KG  GLG S+         S  +++  I P
Sbjct: 450  ------GYNTKKIGKRLN--------IQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILP 495

Query: 1383 NGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSK--VKIIFIRNKDAVNQMA 1440
             GAA +DGRL+  D L+E+NG  L G+S +   S+++    +  V ++  R +DA +   
Sbjct: 496  RGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRE 555

Query: 1441 VCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELP-KDQGGLGIAISE 1499
            +   NA EP           E E  V T D   +  +F      E+P  D G  G+ +S 
Sbjct: 556  L---NA-EPSQMQIPKETKAEDEDIVLTPDGTREFLTF------EVPLNDSGSAGLGVSV 605

Query: 1500 EDTLS-------GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA 1552
            +   S       G+ +KS+   G A+ DGRL+V DQ++AV+ E ++G   +  +  L+ +
Sbjct: 606  KGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665

Query: 1553 KMT 1555
              T
Sbjct: 666  MST 668



 Score =  106 bits (265), Expect = 2e-22
 Identities = 103/399 (25%), Positives = 163/399 (40%), Gaps = 89/399 (22%)

Query: 1481 VQHLELPKDQGGLGIAI----SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEI 1536
            V+ +E+P D G LGI +    +      G+++K L + G A  +   +  D I+ ++D  
Sbjct: 272  VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331

Query: 1537 VVGYPIEKFISLLKTAKMTVKLTIHAE------------------------NPDSQAVPS 1572
            +     E+   + + A  T  +  H                          +PDSQ + +
Sbjct: 332  LRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDN 391

Query: 1573 AAGAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIP-------- 1624
             +  ++G           P+   P PE I + SR    A  +  P + P           
Sbjct: 392  RSVNSAGLHTVQR----APRLNHP-PEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTT 446

Query: 1625 ----------GCETTIEISKGRTGLGLSIVGGSDTLLGA--IIIHEVYEEGAACKDGRLW 1672
                      G    I++ KG  GLG SI     T+ G+  I +  +   GAA +DGRL 
Sbjct: 447  VSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLK 506

Query: 1673 AGDQILEVNGIDLRKATHDEAINVLRQTPQR--VRLTLYRDEAPY--------------- 1715
            AGD+++EVNG+DL   + +E +++LR T     V L ++R E  +               
Sbjct: 507  AGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIP 566

Query: 1716 KEEEVCD--------------TLTIELQKKPGKGLGLSIVGKRN-----DTGVFVSDIVK 1756
            KE +  D              T  + L      GLG+S+ G R+     D G+FV  I+ 
Sbjct: 567  KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIIN 626

Query: 1757 GGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
            GG A  DGRL   DQ++ VNGE +   T +     L+ S
Sbjct: 627  GGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665



 Score =  104 bits (260), Expect = 8e-22
 Identities = 79/228 (34%), Positives = 113/228 (49%), Gaps = 16/228 (7%)

Query: 240 ASTISAHSNPVHWQHMETIELVNDGSGLGFGI------IGGKATGVIVKTILPGGVADQH 293
           ++T+S+  N         I+L     GLGF I      IGG A  + VK ILP G A Q 
Sbjct: 444 STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAP-IYVKNILPRGAAIQD 502

Query: 294 GRLCSGDHILKIGDTDLAGMSSEQVAQVLR--QCGNRVKLMIARGAIEERTAPTALGITL 351
           GRL +GD ++++   DL G S E+V  +LR  +    V L++ R   E+   P  L    
Sbjct: 503 GRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQ--EDAFHPRELNAEP 560

Query: 352 SS----SPTSTPELRVDASTQKGEESETFDVELTKNVQ-GLGITIAGYIGDKKLEPSGIF 406
           S       T   +  +  +     E  TF+V L  +   GLG+++ G    +     GIF
Sbjct: 561 SQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIF 620

Query: 407 VKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT 454
           VKSI    A   DGR+++ DQ+IAV+G +L G TNQ A+E LR +  T
Sbjct: 621 VKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668



 Score =  101 bits (252), Expect = 7e-21
 Identities = 104/417 (24%), Positives = 183/417 (43%), Gaps = 35/417 (8%)

Query: 1630 IEISKGRTGLGLSIVG----GSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDL 1685
            +E+      LG+ +V     G  TL   +++  + + G A  +      D I+ +N  DL
Sbjct: 275  VEVPNDGGPLGIHVVPFSARGGRTL--GLLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332

Query: 1686 RKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRN 1745
            R    ++A ++ RQ  +   +  +   A  KE+                   LS   K N
Sbjct: 333  RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYE----------------QLSQSEKNN 376

Query: 1746 DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFP 1805
                + S          D R +    +  V      N   E + +  ++   +  S   P
Sbjct: 377  ----YYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPP 432

Query: 1806 LSGSSTSESLESSSKKNALASEIQGLR-TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIA 1864
             + +S  +++ S++  +   ++  G R  +++KKG T+ LG SI     +  G  PI++ 
Sbjct: 433  SAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKG-TEGLGFSITSRDVTIGGSAPIYVK 491

Query: 1865 MMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNAS--GSIEMQVVAGGDVS 1922
             + P G A Q  +L+ GDR++ + G    G +  + V+LL++    G++ + V    D  
Sbjct: 492  NILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAF 551

Query: 1923 VVTGHQQEPASSSL-SFTGLTSSSIFQDDLGPPQCKSITL---ERGPDGLGFSIVGGYGS 1978
                   EP+   +   T      I     G  +  +  +   + G  GLG S+ G    
Sbjct: 552  HPRELNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSK 611

Query: 1979 P-HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGT 2034
              H DL I+VK++   GAAS+DGRL+  DQ+IAVNG+SL G T+++A+  L+R+  T
Sbjct: 612  ENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668



 Score = 85.5 bits (210), Expect = 5e-16
 Identities = 120/529 (22%), Positives = 217/529 (41%), Gaps = 64/529 (12%)

Query: 404 GIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLT--LMR 461
           G+ VK + K    EH+   +  D I+ ++  +L+    +QA  + R   +T ++   ++ 
Sbjct: 300 GLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVP 359

Query: 462 RGMKQEAELMSREDVTK--DADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPL 519
              K++ E +S+ +      +  SP +  I  +N   +   L + +    L    E    
Sbjct: 360 AANKEQYEQLSQSEKNNYYSSRFSPDSQYI--DNRSVNSAGLHTVQRAPRLNHPPEQIDS 417

Query: 520 LSAEIEEIEDAQKQEAALLTKWQRIM------GINYEIVVAHVS----KFSENSGLGI-S 568
            S        + K  +A  +  Q +       G N + +   ++    K +E  G  I S
Sbjct: 418 HSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITS 477

Query: 569 LEATVGHH---FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE 625
            + T+G     +++++LP G     G+L +GD L+EVNG+ L+G++ ++VV++L+   +E
Sbjct: 478 RDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKME 537

Query: 626 VTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTE 685
                   TV      + D+      EL  +P          +E ED VL   D  +   
Sbjct: 538 -------GTVSLLVFRQEDAFH--PRELNAEPSQMQIPKETKAEDEDIVLT-PDGTREFL 587

Query: 686 EVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRL 745
             + PL            + GS GLG S+   +   + A   I ++S++ GG A KDGRL
Sbjct: 588 TFEVPLN-----------DSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRL 636

Query: 746 LPGDRLMFVNDVNLENSSLEEAVEALK------GAPSGTVRIGVAKPL-----------P 788
              D+L+ VN  +L   + ++A+E L+      G   G +++ VA+ +           P
Sbjct: 637 RVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSP 696

Query: 789 LSPEEGYVSAKEDSFLYPPHSCEEA--GLADKPLFRADLALVGTNDADLVDESTFESPYS 846
             PE    +A +D      HS      GL + P   A L+ +           T   P  
Sbjct: 697 PGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMGESGKYQLSPTVNMPQD 756

Query: 847 P----ENDSIYSTQASILSLHGSSCGDGLNYGSSLPSSPPKDVIENSCD 891
                E+D +      +     SS  D + + ++   +  K  I +S D
Sbjct: 757 DTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAISDSAD 805



 Score = 84.3 bits (207), Expect = 1e-15
 Identities = 115/502 (22%), Positives = 203/502 (40%), Gaps = 114/502 (22%)

Query: 997  LQNVSKESFERTINIAKGNSSLGMTV----SANKDGLGMIVRSIIHGGAISRDGRIAIGD 1052
            + N S +   + + +      LG+ V    +     LG++V+ +  GG    +      D
Sbjct: 263  IPNFSLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFREND 322

Query: 1053 CILSINEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALD 1112
            CI+ IN+    +    QA+ M R+ ++  P I    VPA + E+++  L Q         
Sbjct: 323  CIVRINDGDLRNRRFEQAQHMFRQ-AMRTPIIWFHVVPAANKEQYE-QLSQSEKNNYYSS 380

Query: 1113 IFSS---------------YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVEL--- 1154
             FS                +T +  P L    E     S L ++A+ +   P        
Sbjct: 381  RFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQ 440

Query: 1155 ------------WREPSKSLGISIVGG-RGMGSRLSNGEVMRG----IFIKHVLEDSPAG 1197
                         ++  K L I +  G  G+G  +++ +V  G    I++K++L    A 
Sbjct: 441  NVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAI 500

Query: 1198 KNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHN 1257
            ++G LK GDR++EV+G+DL   S E+               V S++   +     SLL  
Sbjct: 501  QDGRLKAGDRLIEVNGVDLVGKSQEE---------------VVSLLRSTKMEGTVSLLV- 544

Query: 1258 LYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSA 1317
                  F   + F    ++NA+  PSQ +   E                      T++  
Sbjct: 545  ------FRQEDAFHPR-ELNAE--PSQMQIPKE----------------------TKAED 573

Query: 1318 SKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSR---MS 1374
              I    D   EF             LT E+ + +   G +GLG+S+ GN+ +     + 
Sbjct: 574  EDIVLTPDGTREF-------------LTFEVPLND--SGSAGLGVSVKGNRSKENHADLG 618

Query: 1375 VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPS-------KVKI 1427
            +F+  I   GAA KDGRL++ D+L+ +NG+ L G+++Q+A   ++ + S        +++
Sbjct: 619  IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQL 678

Query: 1428 IFIRNKDAVNQMAVCPGNAVEP 1449
            I  R     N++   PG+   P
Sbjct: 679  IVARRISKCNELK-SPGSPPGP 699



 Score = 81.6 bits (200), Expect = 7e-15
 Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 27/241 (11%)

Query: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGLGIAISEEDTLSG----VIIKSLTEHGVAATDGR 1522
            TT  +  +        +++L K   GLG +I+  D   G    + +K++   G A  DGR
Sbjct: 445  TTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGR 504

Query: 1523 LKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKK 1582
            LK GD+++ V+   +VG   E+ +SLL++ KM   +++     +    P    A   +  
Sbjct: 505  LKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQ-- 562

Query: 1583 NSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLS 1642
                 + +P+    E E I  T   +   +    P                 G  GLG+S
Sbjct: 563  -----MQIPKETKAEDEDIVLTPDGTREFLTFEVPLN-------------DSGSAGLGVS 604

Query: 1643 IVGGSDTLLGA---IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQ 1699
            + G       A   I +  +   GAA KDGRL   DQ++ VNG  L   T+ +A+  LR+
Sbjct: 605  VKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664

Query: 1700 T 1700
            +
Sbjct: 665  S 665



 Score = 79.7 bits (195), Expect = 3e-14
 Identities = 42/84 (50%), Positives = 58/84 (69%), Gaps = 2/84 (2%)

Query: 1958 SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
            +I L++G +GLGFSI     +  G  PIYVK +  +GAA +DGRLK GD++I VNG  L 
Sbjct: 461  NIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLV 520

Query: 2018 GVTHEEAVAILKRTK--GTVTLMV 2039
            G + EE V++L+ TK  GTV+L+V
Sbjct: 521  GKSQEEVVSLLRSTKMEGTVSLLV 544



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 71/273 (26%), Positives = 119/273 (43%), Gaps = 47/273 (17%)

Query: 353 SSPTSTPELRVDASTQKGEESETF----DVELTKNVQGLGITIAGYIGDKKLEPSG-IFV 407
           S+P S P+     +   G  ++      +++L K  +GLG +I     D  +  S  I+V
Sbjct: 433 SAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITS--RDVTIGGSAPIYV 490

Query: 408 KSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQE 467
           K+I    A   DGR++ GD++I V+G +L G + ++ V +LR T     ++L+    +QE
Sbjct: 491 KNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLL--VFRQE 548

Query: 468 AELMSREDVTKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEI 527
                RE      +  P    I KE   +DED + +   T    T E            +
Sbjct: 549 DAFHPRE-----LNAEPSQMQIPKETKAEDEDIVLTPDGTREFLTFE----------VPL 593

Query: 528 EDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPV 587
            D+      +  K  R             SK   ++ LGI         F++S++  G  
Sbjct: 594 NDSGSAGLGVSVKGNR-------------SK-ENHADLGI---------FVKSIINGGAA 630

Query: 588 GHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620
              G+L   D+L+ VNG +LLG+ +QD +  L+
Sbjct: 631 SKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 67/280 (23%), Positives = 110/280 (39%), Gaps = 51/280 (18%)

Query: 141 LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200
           LK  + GLGFS+        G   I+V+ I     A +DGRLK  D+++ +NG       
Sbjct: 464 LKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNG------- 516

Query: 201 THQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQ------- 253
                + ++ K+++ V  ++    +   VS +V R   A      ++ P   Q       
Sbjct: 517 -----VDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETKA 571

Query: 254 HMETIELVNDG----------------SGLGFGIIGGKA------TGVIVKTILPGGVAD 291
             E I L  DG                +GLG  + G ++       G+ VK+I+ GG A 
Sbjct: 572 EDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631

Query: 292 QHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC----GNRVKLMIARGAIEERTAPTAL 347
           + GRL   D ++ +    L G +++   + LR+     GN+      RG I+   A    
Sbjct: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNK------RGMIQLIVARRIS 685

Query: 348 GITLSSSPTSTPELRVDASTQKGEESETFDVELTKNVQGL 387
                 SP S P   +   T   +        L   ++GL
Sbjct: 686 KCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGL 725



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 42/288 (14%)

Query: 955  SHLPSEVISSAELP-----SVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTI 1009
            +H P ++ S + LP     S  P SA   +   +  ++++         N  K      I
Sbjct: 409  NHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG------YNTKKIGKRLNI 462

Query: 1010 NIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILSINEESTISV 1065
             + KG   LG ++++    +G    + V++I+  GA  +DGR+  GD ++ +N    +  
Sbjct: 463  QLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522

Query: 1066 TNAQARAMLRRHSLIGPDIKITY--VPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIP 1123
            +  +  ++LR   + G    + +    A H  E      Q                    
Sbjct: 523  SQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQM------------------- 563

Query: 1124 ELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMR 1183
            ++P+  + E E+  L       +     V L    S  LG+S+ G R   S+ ++ ++  
Sbjct: 564  QIPKETKAEDEDIVLTPDGTREF-LTFEVPLNDSGSAGLGVSVKGNR---SKENHADL-- 617

Query: 1184 GIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA 1231
            GIF+K ++    A K+G L+  D+++ V+G  L   +++ A+E +R++
Sbjct: 618  GIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRS 665



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 5/75 (6%)

Query: 255 METIELVNDGSGLGFGII-----GGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTD 309
           ++ +E+ NDG  LG  ++     GG+  G++VK +  GG A+        D I++I D D
Sbjct: 272 VKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGD 331

Query: 310 LAGMSSEQVAQVLRQ 324
           L     EQ   + RQ
Sbjct: 332 LRNRRFEQAQHMFRQ 346



 Score = 32.0 bits (71), Expect = 6.4
 Identities = 17/59 (28%), Positives = 32/59 (54%), Gaps = 2/59 (3%)

Query: 136 EVFELLKPPSGG--LGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAIN 192
           ++ +L++ P+ G  LG  VV   +     LG+ V+ +++G  A  +   +E D I+ IN
Sbjct: 270 DMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRIN 328


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score =  109 bits (272), Expect = 3e-23
 Identities = 167/837 (19%), Positives = 325/837 (38%), Gaps = 136/837 (16%)

Query: 703  LEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENS 762
            L+K + G GF+I+   +P +     + ++S++P G A +DG++  GD ++++N+V +   
Sbjct: 429  LKKSNMGFGFTIIGGDEPDE----FLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 484

Query: 763  SLEEAVEALKGAPSG-TVRIGVAK--PLPLSPEEGYVSAKED-SFLYPPHSCEEAGLADK 818
            +  + V+  +  P G +V + + +  PLP  PE+   S     + +  P      G  + 
Sbjct: 485  THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNY 544

Query: 819  PLFRADLALVGTNDADLVD---------------ESTFESPYSPENDSIYS---TQASIL 860
              +   ++    +  D+ D               + T+  P   +N S+ S   TQA ++
Sbjct: 545  ETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELM 604

Query: 861  SLHGSSCGDGLNYGSSLPSSPP----KDVIENSCDPVL---DLHMSLEELYTQNLLQRQD 913
            +L       G  +G ++  SP     K +++    P L   DL + + +   QNL     
Sbjct: 605  TLTIVKGAQG--FGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNL----- 657

Query: 914  ENTPSVDISMGPASGFTINDYTPANAIEQQYECENTIV--WTESHLPSEVISSAELP--- 968
             +T  VDI      G   +           ++    I+  W     P   +S+  +P   
Sbjct: 658  SHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNL 717

Query: 969  --------SVLPDSAG-----KGSEYLLEQSSLACNAE--------CVMLQNVSKESFER 1007
                    S  PDS       K   Y L + S A               + +   +  E 
Sbjct: 718  PFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777

Query: 1008 TINIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVT 1066
             +++ +  S  G  +   ++ G  +++ ++I  G+  RDGR+  GD ++ ++       T
Sbjct: 778  DVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKT 837

Query: 1067 -------------NAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDI 1113
                         N Q    +RR  L G +      P        +S    S R      
Sbjct: 838  HRYVIDLMHHAARNGQVNLTVRRKVLCGGEP----CPENGRSPGSVSTHHSSPR----SD 889

Query: 1114 FSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMG 1173
            +++YT  +              +       S+  Q   V + R+ ++  G  I+      
Sbjct: 890  YATYTNSN-------HAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVII------ 936

Query: 1174 SRLSNGEVMRGIFIKH----VLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIR 1229
            S L+  E    I + H    +++ SPA +   LK GDRI+ V+G  + +  H   V+ I+
Sbjct: 937  SSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996

Query: 1230 KAGNPVVFMV--QSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADS-------------- 1273
             AG  V   +  Q  +N P  +P       +  +   +  +P A                
Sbjct: 997  DAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAP 1056

Query: 1274 ---LQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQ----DVDK 1326
               LQ+   +   +SE +  +     +  PP + + +   D+ Q       Q    D  +
Sbjct: 1057 PQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ 1116

Query: 1327 EDEFGYSWKNIRERYGTLTG-------ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVG 1379
                 Y   +   R   L+        +   +++EKG  G G S+ G ++  +M ++++ 
Sbjct: 1117 PPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREY-KMDLYVLR 1175

Query: 1380 IDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
            +  +G A ++GR+++ D+++EING+     +H  A  +IK    +V+++  R    V
Sbjct: 1176 LAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQV 1232



 Score =  103 bits (257), Expect = 2e-21
 Identities = 182/838 (21%), Positives = 333/838 (39%), Gaps = 106/838 (12%)

Query: 1011 IAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSINEESTISVTNAQ 1069
            + K N   G T+    +    + V+S+I  G  ++DG++  GD I+ INE   +  T+A 
Sbjct: 429  LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488

Query: 1070 ARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSGRVMA-----LDI 1113
                L +   IG  + +              PA  +    +++ ++   VM       + 
Sbjct: 489  V-VKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVP-PLAIMERPPPVMVNGRHNYET 546

Query: 1114 FSSY---TGRDIPELPEREEGEGEESELQNTAYSNWNQP------RRVELWREPSKSLGI 1164
            +  Y   T + +P++ +R                 +  P               ++ + +
Sbjct: 547  YLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTL 606

Query: 1165 SIV-GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQ 1223
            +IV G +G G  +++     G  +K +L+    G  G L  GD IVE++  ++++ SH +
Sbjct: 607  TIVKGAQGFGFTIADSPT--GQRVKQILDIQ--GCPG-LCEGDLIVEINQQNVQNLSHTE 661

Query: 1224 AVEAIRKAGNPVVFMVQSIINR-----PRKSPLPSLLHNLYPKYNFSSTNPFADSLQINA 1278
             V+ ++    P+      II+R     P K+P P +  + +       T+  A ++  N 
Sbjct: 662  VVDILKDC--PIGSETSLIIHRGGFFSPWKTPKPIM--DRWENQGSPQTSLSAPAIPQNL 717

Query: 1279 DKAPSQSESE-PEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNI 1337
               P+   S  P+         P P    E      +S      +   + D  G  +K +
Sbjct: 718  PFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKEL 777

Query: 1338 RERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADE 1397
                     ++H+  +E   SG G  + G  D     + I  +   G+A +DGRL   DE
Sbjct: 778  ---------DVHLRRME---SGFGFRILGG-DEPGQPILIGAVIAMGSADRDGRLHPGDE 824

Query: 1398 LLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENL 1457
            L+ ++G  + G++H+    ++  A    ++     +  +     CP N   P   ++ + 
Sbjct: 825  LVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHS 884

Query: 1458 QNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQ-GGLGIAISEEDTLSGVIIKSLT--EH 1514
              +    T T S+ A   S+    +       Q   + I   E +    VII SL   E 
Sbjct: 885  SPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPES 944

Query: 1515 GVAAT---------DG-------RLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKL 1558
            G   T         DG       +LKVGD+ILAV+ + ++  P    + L+K A ++V L
Sbjct: 945  GSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTL 1004

Query: 1559 TIHAENPDSQAVPSAAGAASGEKKN--SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASD 1616
             I  +    + + S   A S EK++  + QS +  QS   +P         +TP    + 
Sbjct: 1005 RIIPQ----EELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSP-------ATP----NS 1049

Query: 1617 PATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQ 1676
            P   P  P     +++ +G      S V     +   I      +      D R   G  
Sbjct: 1050 PIAQPAPP---QPLQL-QGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGD 1105

Query: 1677 ILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGL 1736
              +   +D R+      ++  + +P   +  L    + Y++ +  D  T++++K   KG 
Sbjct: 1106 YQQPPPLDYRQPP---LLDYRQHSPDTRQYPL----SDYRQPQDFDYFTVDMEKG-AKGF 1157

Query: 1737 GLSIVGKRN-DTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
            G SI G R     ++V  + + G A  +GR+  GDQI+ +NGE  R+ T      L+K
Sbjct: 1158 GFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215



 Score = 85.1 bits (209), Expect = 6e-16
 Identities = 150/684 (21%), Positives = 261/684 (38%), Gaps = 204/684 (29%)

Query: 141  LKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTI 200
            LK  + G GF+++G    +  +  + V+ +     A +DG+++  D I+ IN +      
Sbjct: 429  LKKSNMGFGFTIIG---GDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYIN-EVCVLGH 484

Query: 201  THQQAISILQKAK--DTVQLVIARG-SLP--------QLVSPI----------------- 232
            TH   + + Q      +V LV+ RG  LP         +V P+                 
Sbjct: 485  THADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNY 544

Query: 233  ------VSRSPSAASTI------SAHSNPVHWQ------------------------HME 256
                  +SR+  +   I      S HS P   Q                         + 
Sbjct: 545  ETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELM 604

Query: 257  TIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHG--RLCSGDHILKIGDTDLAGMS 314
            T+ +V    G GF  I    TG  VK IL     D  G   LC GD I++I   ++  +S
Sbjct: 605  TLTIVKGAQGFGF-TIADSPTGQRVKQIL-----DIQGCPGLCEGDLIVEINQQNVQNLS 658

Query: 315  SEQVAQVLRQC--GNRVKLMIARGAI--------------EERTAP-TALG--------- 348
              +V  +L+ C  G+   L+I RG                E + +P T+L          
Sbjct: 659  HTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLP 718

Query: 349  ----ITLSSSPTSTP------------------------------ELRVDASTQKGEESE 374
                +  SS P ST                                 R+D+S   G + +
Sbjct: 719  FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSS---GPDYK 775

Query: 375  TFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGT 434
              DV L +   G G  I G  GD+  +P  I + ++    + + DGR+  GD+++ VDG 
Sbjct: 776  ELDVHLRRMESGFGFRILG--GDEPGQP--ILIGAVIAMGSADRDGRLHPGDELVYVDGI 831

Query: 435  NLQGFTNQQAVEVLRHTGQT--VLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKE 492
             + G T++  ++++ H  +   V LT+ R+       ++   +   +   SP   S+   
Sbjct: 832  PVAGKTHRYVIDLMHHAARNGQVNLTVRRK-------VLCGGEPCPENGRSP--GSVSTH 882

Query: 493  NYEKDEDFLSSTRNTNILPTEE----EGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGIN 548
            +     D+ + T + +  P+      EG+   S +  ++   +K+            G  
Sbjct: 883  HSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENE----------GFG 932

Query: 549  YEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLL 608
            + ++++ +++    S + +        H I  ++   P     KL  GD +L VNG +++
Sbjct: 933  F-VIISSLNRPESGSTITVP-------HKIGRIIDGSPADRCAKLKVGDRILAVNGQSII 984

Query: 609  GENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIELTEKPHVDLGEFIGSS 668
               H D+V ++K+  + VT+    R +P   Q EL+S        T  P         SS
Sbjct: 985  NMPHADIVKLIKDAGLSVTL----RIIP---QEELNS-------PTSAP---------SS 1021

Query: 669  ETEDPVLAMTDAGQSTEEVQAPLA 692
            E + P+     A QS    Q+PLA
Sbjct: 1022 EKQSPM-----AQQSPLAQQSPLA 1040



 Score = 70.5 bits (171), Expect = 2e-11
 Identities = 119/620 (19%), Positives = 222/620 (35%), Gaps = 145/620 (23%)

Query: 1344 LTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEING 1403
            L G      L+K + G G ++ G  +     + +  + P+G A +DG+++  D ++ IN 
Sbjct: 420  LKGTFLSTTLKKSNMGFGFTIIGGDEPDEF-LQVKSVIPDGPAAQDGKMETGDVIVYINE 478

Query: 1404 QILYGRSHQNASSIIKCAP--SKVKIIFIRN-------KDAVNQMAVCPGNAVEPLPSNS 1454
              + G +H +   + +  P    V ++  R        +D  N M         P P   
Sbjct: 479  VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMV 538

Query: 1455 ENLQNKET------------------------------------EPTVTTSDAAVDLSSF 1478
                N ET                                     P V   + ++  S  
Sbjct: 539  NGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGA 598

Query: 1479 KNVQHLELPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVV 1538
               + + L   +G  G   +  D+ +G  +K + +  +    G L  GD I+ ++ + V 
Sbjct: 599  TQAELMTLTIVKGAQGFGFTIADSPTGQRVKQILD--IQGCPG-LCEGDLIVEINQQNVQ 655

Query: 1539 GYPIEKFISLLKTAKM--TVKLTIHA--------------ENPDSQAVPSAAGAASGEKK 1582
                 + + +LK   +     L IH               +  ++Q  P  + +A    +
Sbjct: 656  NLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQ 715

Query: 1583 NSSQSLMVPQSG-----------SPEPESIRNTSRSSTPAIFASDPATCPIIPGC----- 1626
            N      + +S             P+P  +   SR+   +     P T   +        
Sbjct: 716  NLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYK 775

Query: 1627 ETTIEISKGRTGLGLSIVGGSDT----LLGAIIIHEVYEEGAACKDGRLWAGDQILEVNG 1682
            E  + + +  +G G  I+GG +     L+GA+I       G+A +DGRL  GD+++ V+G
Sbjct: 776  ELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAM-----GSADRDGRLHPGDELVYVDG 830

Query: 1683 IDLRKATHDEAINVLRQTPQ--RVRLTLYR----------------------------DE 1712
            I +   TH   I+++    +  +V LT+ R                            D 
Sbjct: 831  IPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDY 890

Query: 1713 APYKEEEVC-----------------DTLTIELQKKPGKGLGLSIVGKRN--DTGVFVS- 1752
            A Y                        T  + + +K  +G G  I+   N  ++G  ++ 
Sbjct: 891  ATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITV 950

Query: 1753 -----DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFTFPLS 1807
                  I+ G  AD   +L  GD+IL VNG+ + N     +  L+K +  S++    P  
Sbjct: 951  PHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQE 1010

Query: 1808 GSSTSESLESSSKKNALASE 1827
              ++  S  SS K++ +A +
Sbjct: 1011 ELNSPTSAPSSEKQSPMAQQ 1030



 Score = 64.7 bits (156), Expect = 9e-10
 Identities = 51/208 (24%), Positives = 90/208 (43%), Gaps = 28/208 (13%)

Query: 1860 PIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGS------IEM 1913
            PI I  +   G A +  +L  GD +V + G    G TH   ++L+ +A+ +      +  
Sbjct: 801  PILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRR 860

Query: 1914 QVVAGGDVSVVTG--------HQQEPASSSLSFTGLTSSSIFQDDLGPP--------QCK 1957
            +V+ GG+     G        H   P S   ++T  ++ +    +  PP        Q  
Sbjct: 861  KVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYTN-SNHAAPSSNASPPEGFASHSLQTS 919

Query: 1958 SITLERGP-DGLGFSIVGGYGSPHGD----LPIYVKTVFAKGAASEDGRLKRGDQIIAVN 2012
             + + R   +G GF I+     P       +P  +  +     A    +LK GD+I+AVN
Sbjct: 920  DVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVN 979

Query: 2013 GQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
            GQS+  + H + V ++K    +VTL ++
Sbjct: 980  GQSIINMPHADIVKLIKDAGLSVTLRII 1007



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 118/500 (23%), Positives = 207/500 (41%), Gaps = 70/500 (14%)

Query: 334 ARGAIEERTAP-TALGITLSSSP--TSTPELRVDASTQKGEESETFDVELTKNVQGLGIT 390
           A+  +++   P T LG     +P     P    DAS  KG    T    L K+  G G T
Sbjct: 383 AKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLST---TLKKSNMGFGFT 439

Query: 391 IAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH 450
           I G  GD+  E   + VKS+        DG+++ GD I+ ++   + G T+   V++ + 
Sbjct: 440 IIG--GDEPDE--FLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQS 495

Query: 451 T--GQTVLLTLMRR-GMKQEAELMSREDVTKDADLSPVNASII--KENYEKDEDFLSSTR 505
              GQ+V L L R   +  + E  +   V   A +      ++  + NYE   +++S T 
Sbjct: 496 VPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTS 555

Query: 506 NTNILPTEEEGYPLLSAEIEEIEDA------QKQEAALLTKWQRIMGINYEIVVAHVSKF 559
            +    T+   + L S   +   D            ++ +          E++   + K 
Sbjct: 556 QSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSG----ATQAELMTLTIVKG 611

Query: 560 SENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNIL 619
           ++  G  I+ ++  G    + +  +G  G    L  GD ++E+N   +   +H +VV+IL
Sbjct: 612 AQGFGFTIA-DSPTGQRVKQILDIQGCPG----LCEGDLIVEINQQNVQNLSHTEVVDIL 666

Query: 620 KELPI--EVTMVCCR-------RTVPPTTQ------SELDSLDLCDI--ELTEKPHVDLG 662
           K+ PI  E +++  R       +T  P         S   SL    I   L   P +   
Sbjct: 667 KDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRS 726

Query: 663 EFIGSSETEDPVLAMTDAGQSTEEVQA------------PLAMWEAGIQHIELE----KG 706
            F  S+E  DP     D  +  E+ +A               M  +G  + EL+    + 
Sbjct: 727 SFPDSTEAFDP--RKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRM 784

Query: 707 SKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEE 766
             G GF IL   +P  P    I+I +++  G A++DGRL PGD L++V+ + +   +   
Sbjct: 785 ESGFGFRILGGDEPGQP----ILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840

Query: 767 AVEAL-KGAPSGTVRIGVAK 785
            ++ +   A +G V + V +
Sbjct: 841 VIDLMHHAARNGQVNLTVRR 860



 Score = 63.2 bits (152), Expect = 3e-09
 Identities = 32/82 (39%), Positives = 50/82 (60%), Gaps = 1/82 (1%)

Query: 1629 TIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKA 1688
            T+++ KG  G G SI GG +  +   ++  + E+G A ++GR+  GDQI+E+NG   R  
Sbjct: 1147 TVDMEKGAKGFGFSIRGGREYKMDLYVLR-LAEDGPAIRNGRMRVGDQIIEINGESTRDM 1205

Query: 1689 THDEAINVLRQTPQRVRLTLYR 1710
            TH  AI +++   +RVRL L R
Sbjct: 1206 THARAIELIKSGGRRVRLLLKR 1227



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 104/482 (21%), Positives = 175/482 (36%), Gaps = 108/482 (22%)

Query: 1623 IPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNG 1682
            + G   +  + K   G G +I+GG D     + +  V  +G A +DG++  GD I+ +N 
Sbjct: 420  LKGTFLSTTLKKSNMGFGFTIIGG-DEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINE 478

Query: 1683 IDLRKATHDEAINVLRQTP--QRVRLTLYRD-EAPYKEEEVCDTLT--IELQKKPGKGLG 1737
            + +   TH + + + +  P  Q V L L R    P+  E+  +++   + + ++P     
Sbjct: 479  VCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPP--- 535

Query: 1738 LSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEG 1797
              +V  R++   ++  I +                     + V + T     +L  +   
Sbjct: 536  -VMVNGRHNYETYLEYISR-------------------TSQSVPDITDRPPHSLHSMPTD 575

Query: 1798 SLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLG 1857
                 T+P      + S+ SS    A       L T+ + KG         A G G  + 
Sbjct: 576  GQLDGTYPPPVHDDNVSMASSGATQA------ELMTLTIVKG---------AQGFGFTIA 620

Query: 1858 DVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV- 1916
            D P    +     +      L  GD IV I   + + ++HT+ V++LK+     E  ++ 
Sbjct: 621  DSPTGQRVKQILDIQG-CPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679

Query: 1917 -AGGDVSVVT---------GHQQEPASS--------SLSFTGLTSSSIFQDDLG------ 1952
              GG  S             +Q  P +S        +L F      S F D         
Sbjct: 680  HRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRK 739

Query: 1953 --------------------PPQCKSITLERGPD-------------GLGFSIVGGYGSP 1979
                                PP+        GPD             G GF I+GG    
Sbjct: 740  PDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGG---D 796

Query: 1980 HGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRT--KGTVTL 2037
                PI +  V A G+A  DGRL  GD+++ V+G  + G TH   + ++      G V L
Sbjct: 797  EPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNL 856

Query: 2038 MV 2039
             V
Sbjct: 857  TV 858



 Score = 55.5 bits (132), Expect = 5e-07
 Identities = 29/82 (35%), Positives = 47/82 (57%), Gaps = 3/82 (3%)

Query: 1958 SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLE 2017
            ++ +E+G  G GFSI GG       + +YV  +   G A  +GR++ GDQII +NG+S  
Sbjct: 1147 TVDMEKGAKGFGFSIRGGR---EYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203

Query: 2018 GVTHEEAVAILKRTKGTVTLMV 2039
             +TH  A+ ++K     V L++
Sbjct: 1204 DMTHARAIELIKSGGRRVRLLL 1225



 Score = 54.7 bits (130), Expect = 9e-07
 Identities = 74/297 (24%), Positives = 118/297 (39%), Gaps = 51/297 (17%)

Query: 1698 RQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG--VFVSDIV 1755
            +Q P R    +      YKE      L + L++    G G  I+G  ++ G  + +  ++
Sbjct: 757  QQVPPRTSFRMDSSGPDYKE------LDVHLRRMES-GFGFRILGG-DEPGQPILIGAVI 808

Query: 1756 KGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALL---------------KV------ 1794
              G AD DGRL  GD+++ V+G  V   T   V  L+               KV      
Sbjct: 809  AMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEP 868

Query: 1795 ------SEGSLSSF-TFPLSGSST-SESLESSSKKNA-----LASEIQGLRTVEMKKGPT 1841
                  S GS+S+  + P S  +T + S  ++   NA      AS       V + +   
Sbjct: 869  CPENGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKEN 928

Query: 1842 DSLGISIAGGVGSPLGD----VPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTH 1897
            +  G  I   +  P       VP  I  +     A +  KL+VGDRI+ + G S   M H
Sbjct: 929  EGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPH 988

Query: 1898 TQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP 1954
               V L+K+A  S+ ++++   +++  T     P+S   S     S    Q  L  P
Sbjct: 989  ADIVKLIKDAGLSVTLRIIPQEELNSPT---SAPSSEKQSPMAQQSPLAQQSPLAQP 1042



 Score = 52.4 bits (124), Expect = 5e-06
 Identities = 32/97 (32%), Positives = 58/97 (59%), Gaps = 6/97 (6%)

Query: 147  GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
            G GFS+ G R     ++ ++V  + E   A R+GR++  DQI+ ING++  + +TH +AI
Sbjct: 1156 GFGFSIRGGREY---KMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGES-TRDMTHARAI 1211

Query: 207  SILQKAKDTVQLVIARGS--LPQLVSPIVSRSPSAAS 241
             +++     V+L++ RG+  +P+   P    SP+AA+
Sbjct: 1212 ELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAA 1248



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 38/122 (31%), Positives = 60/122 (49%), Gaps = 12/122 (9%)

Query: 1833 TVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTST 1892
            TV+M+KG     G SI GG    +    +++  +   G A +  ++RVGD+I+ I G ST
Sbjct: 1147 TVDMEKG-AKGFGFSIRGGREYKMD---LYVLRLAEDGPAIRNGRMRVGDQIIEINGEST 1202

Query: 1893 EGMTHTQAVNLLKNASGSIEMQVVAG-GDVSVVTGHQQEPA---SSSLSFTGLTSSSIFQ 1948
              MTH +A+ L+K+    + + +  G G V        EPA   S + +  GL    +  
Sbjct: 1203 RDMTHARAIELIKSGGRRVRLLLKRGTGQVP----EYDEPAPWSSPAAAAPGLPEVGVSL 1258

Query: 1949 DD 1950
            DD
Sbjct: 1259 DD 1260



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 28/99 (28%), Positives = 59/99 (59%), Gaps = 5/99 (5%)

Query: 371  EESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIA 430
            ++ + F V++ K  +G G +I G   + K++   ++V  + +      +GR+++GDQII 
Sbjct: 1141 QDFDYFTVDMEKGAKGFGFSIRGG-REYKMD---LYVLRLAEDGPAIRNGRMRVGDQIIE 1196

Query: 431  VDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAE 469
            ++G + +  T+ +A+E+++  G+ V L L++RG  Q  E
Sbjct: 1197 INGESTRDMTHARAIELIKSGGRRVRL-LLKRGTGQVPE 1234



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 29/111 (26%), Positives = 54/111 (48%), Gaps = 5/111 (4%)

Query: 257  TIELVNDGSGLGFGIIGGKA--TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMS 314
            T+++     G GF I GG+     + V  +   G A ++GR+  GD I++I       M+
Sbjct: 1147 TVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMT 1206

Query: 315  SEQVAQVLRQCGNRVKLMIARGA--IEERTAPTALGITLSSSPTSTPELRV 363
              +  ++++  G RV+L++ RG   + E   P       +++P   PE+ V
Sbjct: 1207 HARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAP-GLPEVGV 1256



 Score = 38.5 bits (88), Expect = 0.068
 Identities = 35/116 (30%), Positives = 56/116 (48%), Gaps = 16/116 (13%)

Query: 149  GFSVVGLRSENRGELGIFVQ------EIQEGSVAHRDGRLKETDQILAINGQALDQTITH 202
            GF  V + S NR E G  +        I +GS A R  +LK  D+ILA+NGQ++   + H
Sbjct: 930  GFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI-INMPH 988

Query: 203  QQAISILQKAKDTVQL-VIARGSL--------PQLVSPIVSRSPSAASTISAHSNP 249
               + +++ A  +V L +I +  L         +  SP+  +SP A  +  A  +P
Sbjct: 989  ADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSP 1044



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 6/97 (6%)

Query: 251 HWQHM--ETIELVNDGSGLGFGIIGGKATGVI--VKTILPGGVADQHG-RLCSGDHILKI 305
           HW     E++   N    LGF + GG   G    +  + PG VA + G +L S + +L++
Sbjct: 10  HWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEV 69

Query: 306 GDTDLAGMSSEQVAQVLRQCGNRVKL-MIARGAIEER 341
            +T +AG++   V  V++ C + ++L  + +G I ++
Sbjct: 70  NETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDK 106



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 33/127 (25%), Positives = 55/127 (43%), Gaps = 10/127 (7%)

Query: 1484 LELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1542
            +++ K   G G +I    +    + +  L E G A  +GR++VGDQI+ ++ E       
Sbjct: 1148 VDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTH 1207

Query: 1543 EKFISLLKTAKMTVKLTI--------HAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSG 1594
             + I L+K+    V+L +          + P   + P+AA     E   S    + P S 
Sbjct: 1208 ARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVSLDDGLAPFSP 1267

Query: 1595 S-PEPES 1600
            S P P S
Sbjct: 1268 SHPAPPS 1274



 Score = 37.0 bits (84), Expect = 0.20
 Identities = 20/72 (27%), Positives = 40/72 (55%), Gaps = 4/72 (5%)

Query: 701  IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760
            +++EKG+KG GFSI   ++        + +  L   G A ++GR+  GD+++ +N  +  
Sbjct: 1148 VDMEKGAKGFGFSIRGGRE----YKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTR 1203

Query: 761  NSSLEEAVEALK 772
            + +   A+E +K
Sbjct: 1204 DMTHARAIELIK 1215



 Score = 32.7 bits (73), Expect = 3.7
 Identities = 63/267 (23%), Positives = 95/267 (35%), Gaps = 78/267 (29%)

Query: 1825 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRI 1884
            AS+++G       K      G +I GG   P  D  + +  + P G AAQ  K+  GD I
Sbjct: 417  ASQLKGTFLSTTLKKSNMGFGFTIIGG-DEP--DEFLQVKSVIPDGPAAQDGKMETGDVI 473

Query: 1885 VTICGTSTEGMTHTQAVNLLKNA--SGSIEMQVVAGGDVSVVTGHQQEPASSS------- 1935
            V I      G TH   V L ++     S+ + +  G  +       ++PA+S        
Sbjct: 474  VYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPF---DPEDPANSMVPPLAIM 530

Query: 1936 -----------------LSFTGLTSSSIFQDDLGPP------------------------ 1954
                             L +   TS S+      PP                        
Sbjct: 531  ERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDN 590

Query: 1955 ---------QCKSITLE--RGPDGLGFSIVGGYGSPHGDLPIYVKTVF-AKGAASEDGRL 2002
                     Q + +TL   +G  G GF+I     SP G     VK +   +G       L
Sbjct: 591  VSMASSGATQAELMTLTIVKGAQGFGFTIA---DSPTGQ---RVKQILDIQGCPG----L 640

Query: 2003 KRGDQIIAVNGQSLEGVTHEEAVAILK 2029
              GD I+ +N Q+++ ++H E V ILK
Sbjct: 641  CEGDLIVEINQQNVQNLSHTEVVDILK 667


>gi|119120907 par-3 partitioning defective 3 homolog B isoform a [Homo
            sapiens]
          Length = 1104

 Score =  107 bits (268), Expect = 9e-23
 Identities = 139/583 (23%), Positives = 239/583 (40%), Gaps = 93/583 (15%)

Query: 1493 LGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY----PIEKFISL 1548
            L   + ++D L  V  +    H + +  G         A + E+        PI   I +
Sbjct: 65   LADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEV 124

Query: 1549 LKTA-KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSP-EPESIRNTSR 1606
              +A K+   L +   +      P+    ++      S  L+VP S    E   + N  +
Sbjct: 125  TPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQ 184

Query: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII---IHEVYEEG 1663
            +       + P T   +     T+EIS     LG+ +V    +L G I+   I  + +  
Sbjct: 185  TE----LLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240

Query: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723
             + ++G     + I+++N +DL   T  +A +V RQ  +   + L+    P +  E  + 
Sbjct: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLH--VLPPQNREQYEK 298

Query: 1724 LTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV-----KGGIADADGRLMQGDQILMVNGE 1778
              I           L+I G  N+ GV  + +      K G+  A+           + G 
Sbjct: 299  SVIG---------SLNIFG--NNDGVLKTKVPPPVHGKSGLKTAN-----------LTGT 336

Query: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK 1838
            D  +   +A A+L +     +       S  S S  +   S KNA   +I      ++KK
Sbjct: 337  D--SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI------DLKK 388

Query: 1839 GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHT 1898
            GP + LG ++     S  G  PIF+  + P G A +  +L+ GDRI+ + G    G T  
Sbjct: 389  GP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447

Query: 1899 QAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKS 1958
            + V +L++           G   S+V   Q+                + ++  G P C +
Sbjct: 448  ELVAMLRSTK--------QGETASLVIARQE-------------GHFLPRELKGEPDCCA 486

Query: 1959 ITLER-------------GPDGLGFSIVGGYGSPHG-DLPIYVKTVFAKGAASEDGRLKR 2004
            ++LE              G  GLG S+ G      G DL I++K++   GAA +DGRL+ 
Sbjct: 487  LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546

Query: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRT-------KGTVTLMVL 2040
             DQ+IAVNG+SL G ++ EA+  L+R+       +G + L++L
Sbjct: 547  NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL 589



 Score =  106 bits (264), Expect = 3e-22
 Identities = 98/408 (24%), Positives = 182/408 (44%), Gaps = 63/408 (15%)

Query: 1450 LPSNSENLQNKET----EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-----SEE 1500
            +P +++NL+++E     +  + TS    D  S    + +E+  + G LGI +     S  
Sbjct: 167  VPDSTQNLEDREVLNGVQTELLTSPRTKDTLS-DMTRTVEISGEGGPLGIHVVPFFSSLS 225

Query: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
              + G+ I+ + ++  +  +G     + I+ +++  +V     +   + + A  +  + +
Sbjct: 226  GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285

Query: 1561 HAENPDS--QAVPSAAGAAS----------------GEKKNSSQSLMVPQSGSPEPESIR 1602
            H   P +  Q   S  G+ +                   K+  ++  +  + SPE ++  
Sbjct: 286  HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASA 345

Query: 1603 NTSRSSTPAI-----FASDPATCPIIP------GCETTIEISKGRTGLGLSIVGGSDTLL 1651
            +  ++ +P +       S P+  P++         +  I++ KG  GLG ++V    ++ 
Sbjct: 346  SLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIH 405

Query: 1652 GA--IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ--RVRLT 1707
            G   I +  +  +GAA KDGRL +GD+ILEVNG D+   T +E + +LR T Q     L 
Sbjct: 406  GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465

Query: 1708 LYRDEAPY-----KEEEVCDTLTIE----------LQKKPGKGLGLSIVGKRN-----DT 1747
            + R E  +     K E  C  L++E          L      GLG+S+ G ++     D 
Sbjct: 466  IARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL 525

Query: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
            G+F+  I+ GG A  DGRL   DQ++ VNGE +   +       L+ S
Sbjct: 526  GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 86/278 (30%), Positives = 127/278 (45%), Gaps = 48/278 (17%)

Query: 221 ARGSLPQLVSPIVSR------SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274
           A  SL Q  SP V R      SPS +  +   SN         I+L     GLGF ++  
Sbjct: 343 ASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN--AKKIKIDLKKGPEGLGFTVVTR 400

Query: 275 KAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327
            ++      + VK ILP G A + GRL SGD IL++   D+ G + E++  +LR    G 
Sbjct: 401 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGE 460

Query: 328 RVKLMIARGA-----IEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382
              L+IAR        E +  P    ++L +S                 E  TF++ L  
Sbjct: 461 TASLVIARQEGHFLPRELKGEPDCCALSLETS-----------------EQLTFEIPLND 503

Query: 383 NVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441
           +   GLG+++ G    +     GIF+KSI    A   DGR+++ DQ+IAV+G +L G +N
Sbjct: 504 SGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563

Query: 442 QQAVEVLRHTG----------QTVLLTLMRRGMKQEAE 469
            +A+E LR +           Q V+L    R M+  AE
Sbjct: 564 HEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE 601



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 116/436 (26%), Positives = 189/436 (43%), Gaps = 70/436 (16%)

Query: 1125 LPEREEGEGEESEL---QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
            L +RE   G ++EL     T  +  +  R VE+  E    LGI +V      S LS G +
Sbjct: 174  LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGP-LGIHVVP---FFSSLS-GRI 228

Query: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA-GNPVVFMVQ 1240
            + G+FI+ + ++S + + G     + IV+++ +DL D +  QA +  R+A  +P V +  
Sbjct: 229  L-GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-- 285

Query: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPS--QSESEPEKAPLCSVP 1298
                      LP      Y K    S N F ++  +   K P     +S  + A L    
Sbjct: 286  --------HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD 337

Query: 1299 PPPPSAFAEMGSDHT----QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
             P   A A +  + +    +      S  +     FG S KN ++           I+L+
Sbjct: 338  SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG-SNKNAKKI---------KIDLK 387

Query: 1355 KGHSGLGLSLAGNKDRSRMS---VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411
            KG  GLG ++   +D S      +F+  I P GAA KDGRLQ  D +LE+NG+ + GR+ 
Sbjct: 388  KGPEGLGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446

Query: 1412 QNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDA 1471
            +   ++++             K       V        LP      +  + EP       
Sbjct: 447  EELVAMLR-----------STKQGETASLVIARQEGHFLP------RELKGEPDC----C 485

Query: 1472 AVDLSSFKNVQHLELP-KDQGGLGIAIS-------EEDTLSGVIIKSLTEHGVAATDGRL 1523
            A+ L + + +   E+P  D G  G+ +S       E  T  G+ IKS+   G A  DGRL
Sbjct: 486  ALSLETSEQLT-FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRL 544

Query: 1524 KVGDQILAVDDEIVVG 1539
            ++ DQ++AV+ E ++G
Sbjct: 545  RMNDQLIAVNGESLLG 560



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 81/308 (26%), Positives = 134/308 (43%), Gaps = 26/308 (8%)

Query: 37  KSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLS 96
           + V +  + S  + L     Q ++Q   +   + NI   +   L   V P +  +S L +
Sbjct: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330

Query: 97  PN-----------NGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPS 145
            N           + +L+    P +P + GKP+      L+   +     ++   LK   
Sbjct: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390

Query: 146 GGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205
            GLGF+VV   S   G   IFV+ I     A +DGRL+  D+IL +NG+ +    T ++ 
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-TQEEL 449

Query: 206 ISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVND 263
           +++L+  K  +T  LVIAR          + R         A S     Q    I L + 
Sbjct: 450 VAMLRSTKQGETASLVIARQE-----GHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504

Query: 264 GS-GLGFGIIGGKA------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 316
           GS GLG  + G K+       G+ +K+I+ GG A + GRL   D ++ +    L G S+ 
Sbjct: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564

Query: 317 QVAQVLRQ 324
           +  + LR+
Sbjct: 565 EAMETLRR 572



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 111/486 (22%), Positives = 189/486 (38%), Gaps = 85/486 (17%)

Query: 360 ELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHD 419
           EL     T+      T  VE++     LGI +  +         G+F++ I  +S  + +
Sbjct: 186 ELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKRE 245

Query: 420 GRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVT 477
           G     + I+ ++  +L   T  QA +V R      +VLL ++    +++ E    + V 
Sbjct: 246 GLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE----KSVI 301

Query: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL 537
              ++   N  ++K          S  +  N+  T+       S E +     Q+ ++  
Sbjct: 302 GSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD-------SPETDASASLQQNKSPR 354

Query: 538 LTKW---------QRIMGI----NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRS 580
           + +            +MG     N + +   + K  E  G  +    +  H     F+++
Sbjct: 355 VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 414

Query: 581 VLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQ 640
           +LP+G     G+L SGD +LEVNG  + G   +++V +L+                 T Q
Sbjct: 415 ILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRS----------------TKQ 458

Query: 641 SELDSLDLCDIELTEKPHVDLGEFIGSSETEDP---VLAMTDAGQSTEEVQAPLAMWEAG 697
            E  SL +   E         G F+      +P    L++  + Q T E+  PL      
Sbjct: 459 GETASLVIARQE---------GHFLPRELKGEPDCCALSLETSEQLTFEI--PLN----- 502

Query: 698 IQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
                 + GS GLG S+   +         I I+S++ GG A KDGRL   D+L+ VN  
Sbjct: 503 ------DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556

Query: 758 NLENSSLEEAVEALKGAPS--GTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
           +L   S  EA+E L+ + S  G +R  +   +   PE             P     E G 
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPER------------PMEDPAECGA 604

Query: 816 ADKPLF 821
             KP F
Sbjct: 605 FSKPCF 610



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 118/503 (23%), Positives = 194/503 (38%), Gaps = 129/503 (25%)

Query: 146 GGLGFSVVGLRSENRGE-LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204
           G LG  VV   S   G  LG+F++ I++ S + R+G   E + I+ IN   L    T  Q
Sbjct: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK-TFAQ 269

Query: 205 AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264
           A  + ++A                      +SPS    +  H  P   Q+ E  E    G
Sbjct: 270 AQDVFRQA---------------------MKSPS----VLLHVLPP--QNREQYEKSVIG 302

Query: 265 SGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324
           S   FG   G     ++KT +P  V   HG+  SG     +   +L G  S +       
Sbjct: 303 SLNIFGNNDG-----VLKTKVPPPV---HGK--SG-----LKTANLTGTDSPETD----- 342

Query: 325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV 384
                    A  ++++  +P    +       S+P L         + ++   ++L K  
Sbjct: 343 ---------ASASLQQNKSPR---VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390

Query: 385 QGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443
           +GLG T+     D  +  P  IFVK+I    A   DGR+Q GD+I+ V+G ++ G T ++
Sbjct: 391 EGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEE 448

Query: 444 AVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFL 501
            V +LR T  G+T  L + R                                        
Sbjct: 449 LVAMLRSTKQGETASLVIAR---------------------------------------- 468

Query: 502 SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSE 561
              +  + LP E +G P   A   E  +    E  L       +G++ +         S 
Sbjct: 469 ---QEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLK------GNKSR 519

Query: 562 NSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGE-NHQDVVNILK 620
            +G  + +       FI+S++  G     G+L   D+L+ VNG +LLG+ NH+ +  + +
Sbjct: 520 ETGTDLGI-------FIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572

Query: 621 ELPIE------VTMVCCRRTVPP 637
            + +E      + +V  RR   P
Sbjct: 573 SMSMEGNIRGMIQLVILRRPERP 595



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/259 (25%), Positives = 114/259 (44%), Gaps = 46/259 (17%)

Query: 1001 SKESFERTINIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILS 1056
            +K + +  I++ KG   LG TV      +     + V++I+  GA  +DGR+  GD IL 
Sbjct: 376  NKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 435

Query: 1057 INEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSS 1116
            +N       T  +  AMLR                +  E   + + +Q G          
Sbjct: 436  VNGRDVTGRTQEELVAMLRS--------------TKQGETASLVIARQEGHF-------- 473

Query: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176
                    LP   +GE +   L  +  ++      + L    S  LG+S+ G +   SR 
Sbjct: 474  --------LPRELKGEPDCCAL--SLETSEQLTFEIPLNDSGSAGLGVSLKGNK---SRE 520

Query: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA----G 1232
            +  ++  GIFIK ++    A K+G L+  D+++ V+G  L   S+ +A+E +R++    G
Sbjct: 521  TGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEG 578

Query: 1233 NPVVFMVQSIINRPRKSPL 1251
            N +  M+Q +I R  + P+
Sbjct: 579  N-IRGMIQLVILRRPERPM 596



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%)

Query: 1007 RTINIAKGNSSLGMTV-----SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
            RT+ I+     LG+ V     S +   LG+ +R I       R+G     +CI+ IN   
Sbjct: 202  RTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261

Query: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121
             +  T AQA+ + R+ ++  P + +  +P ++ E+++ S+      + +L+IF +  G  
Sbjct: 262  LVDKTFAQAQDVFRQ-AMKSPSVLLHVLPPQNREQYEKSV------IGSLNIFGNNDGVL 314

Query: 1122 IPELPEREEGEG----------EESELQNTAYSNWNQ-PRRVELWREPS----------- 1159
              ++P    G+           +  E   +A    N+ PR   L  +PS           
Sbjct: 315  KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374

Query: 1160 -----KSLGISI-VGGRGMG----SRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
                 K + I +  G  G+G    +R S+      IF+K++L    A K+G L+ GDRI+
Sbjct: 375  SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434

Query: 1210 EVDGMDLRDASHEQAVEAIR 1229
            EV+G D+   + E+ V  +R
Sbjct: 435  EVNGRDVTGRTQEELVAMLR 454



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 29/69 (42%), Positives = 44/69 (63%), Gaps = 3/69 (4%)

Query: 1354 EKGHSGLGLSLAGNKDRSR---MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410
            + G +GLG+SL GNK R     + +FI  I   GAA KDGRL++ D+L+ +NG+ L G+S
Sbjct: 503  DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKS 562

Query: 1411 HQNASSIIK 1419
            +  A   ++
Sbjct: 563  NHEAMETLR 571



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 30/85 (35%), Positives = 53/85 (62%), Gaps = 6/85 (7%)

Query: 997  LQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIHGGAISRDGRIAIG 1051
            L+   + +FE  +N + G++ LG+++  NK       LG+ ++SIIHGGA  +DGR+ + 
Sbjct: 489  LETSEQLTFEIPLNDS-GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMN 547

Query: 1052 DCILSINEESTISVTNAQARAMLRR 1076
            D ++++N ES +  +N +A   LRR
Sbjct: 548  DQLIAVNGESLLGKSNHEAMETLRR 572



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 32/85 (37%), Positives = 51/85 (60%), Gaps = 7/85 (8%)

Query: 145 SGGLGFSVVGLRSENRG-ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
           S GLG S+ G +S   G +LGIF++ I  G  A +DGRL+  DQ++A+NG++L     H+
Sbjct: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565

Query: 204 ------QAISILQKAKDTVQLVIAR 222
                 +++S+    +  +QLVI R
Sbjct: 566 AMETLRRSMSMEGNIRGMIQLVILR 590


>gi|119120903 par-3 partitioning defective 3 homolog B isoform c [Homo
            sapiens]
          Length = 1136

 Score =  107 bits (268), Expect = 9e-23
 Identities = 139/583 (23%), Positives = 239/583 (40%), Gaps = 93/583 (15%)

Query: 1493 LGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGY----PIEKFISL 1548
            L   + ++D L  V  +    H + +  G         A + E+        PI   I +
Sbjct: 65   LADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPDAFETEVAAQLAAFKPIGGEIEV 124

Query: 1549 LKTA-KMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSP-EPESIRNTSR 1606
              +A K+   L +   +      P+    ++      S  L+VP S    E   + N  +
Sbjct: 125  TPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGGQSLKLVVPDSTQNLEDREVLNGVQ 184

Query: 1607 SSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAII---IHEVYEEG 1663
            +       + P T   +     T+EIS     LG+ +V    +L G I+   I  + +  
Sbjct: 185  TE----LLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNS 240

Query: 1664 AACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDT 1723
             + ++G     + I+++N +DL   T  +A +V RQ  +   + L+    P +  E  + 
Sbjct: 241  RSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLH--VLPPQNREQYEK 298

Query: 1724 LTIELQKKPGKGLGLSIVGKRNDTGVFVSDIV-----KGGIADADGRLMQGDQILMVNGE 1778
              I           L+I G  N+ GV  + +      K G+  A+           + G 
Sbjct: 299  SVIG---------SLNIFG--NNDGVLKTKVPPPVHGKSGLKTAN-----------LTGT 336

Query: 1779 DVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKK 1838
            D  +   +A A+L +     +       S  S S  +   S KNA   +I      ++KK
Sbjct: 337  D--SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKI------DLKK 388

Query: 1839 GPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHT 1898
            GP + LG ++     S  G  PIF+  + P G A +  +L+ GDRI+ + G    G T  
Sbjct: 389  GP-EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQE 447

Query: 1899 QAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPPQCKS 1958
            + V +L++           G   S+V   Q+                + ++  G P C +
Sbjct: 448  ELVAMLRSTK--------QGETASLVIARQE-------------GHFLPRELKGEPDCCA 486

Query: 1959 ITLER-------------GPDGLGFSIVGGYGSPHG-DLPIYVKTVFAKGAASEDGRLKR 2004
            ++LE              G  GLG S+ G      G DL I++K++   GAA +DGRL+ 
Sbjct: 487  LSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546

Query: 2005 GDQIIAVNGQSLEGVTHEEAVAILKRT-------KGTVTLMVL 2040
             DQ+IAVNG+SL G ++ EA+  L+R+       +G + L++L
Sbjct: 547  NDQLIAVNGESLLGKSNHEAMETLRRSMSMEGNIRGMIQLVIL 589



 Score =  106 bits (264), Expect = 3e-22
 Identities = 98/408 (24%), Positives = 182/408 (44%), Gaps = 63/408 (15%)

Query: 1450 LPSNSENLQNKET----EPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-----SEE 1500
            +P +++NL+++E     +  + TS    D  S    + +E+  + G LGI +     S  
Sbjct: 167  VPDSTQNLEDREVLNGVQTELLTSPRTKDTLS-DMTRTVEISGEGGPLGIHVVPFFSSLS 225

Query: 1501 DTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560
              + G+ I+ + ++  +  +G     + I+ +++  +V     +   + + A  +  + +
Sbjct: 226  GRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL 285

Query: 1561 HAENPDS--QAVPSAAGAAS----------------GEKKNSSQSLMVPQSGSPEPESIR 1602
            H   P +  Q   S  G+ +                   K+  ++  +  + SPE ++  
Sbjct: 286  HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTDSPETDASA 345

Query: 1603 NTSRSSTPAI-----FASDPATCPIIP------GCETTIEISKGRTGLGLSIVGGSDTLL 1651
            +  ++ +P +       S P+  P++         +  I++ KG  GLG ++V    ++ 
Sbjct: 346  SLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIH 405

Query: 1652 GA--IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQ--RVRLT 1707
            G   I +  +  +GAA KDGRL +GD+ILEVNG D+   T +E + +LR T Q     L 
Sbjct: 406  GPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGETASLV 465

Query: 1708 LYRDEAPY-----KEEEVCDTLTIE----------LQKKPGKGLGLSIVGKRN-----DT 1747
            + R E  +     K E  C  L++E          L      GLG+S+ G ++     D 
Sbjct: 466  IARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLKGNKSRETGTDL 525

Query: 1748 GVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVS 1795
            G+F+  I+ GG A  DGRL   DQ++ VNGE +   +       L+ S
Sbjct: 526  GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRS 573



 Score = 92.8 bits (229), Expect = 3e-18
 Identities = 86/278 (30%), Positives = 127/278 (45%), Gaps = 48/278 (17%)

Query: 221 ARGSLPQLVSPIVSR------SPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGG 274
           A  SL Q  SP V R      SPS +  +   SN         I+L     GLGF ++  
Sbjct: 343 ASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKN--AKKIKIDLKKGPEGLGFTVVTR 400

Query: 275 KAT-----GVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GN 327
            ++      + VK ILP G A + GRL SGD IL++   D+ G + E++  +LR    G 
Sbjct: 401 DSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQGE 460

Query: 328 RVKLMIARGA-----IEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTK 382
              L+IAR        E +  P    ++L +S                 E  TF++ L  
Sbjct: 461 TASLVIARQEGHFLPRELKGEPDCCALSLETS-----------------EQLTFEIPLND 503

Query: 383 NVQ-GLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441
           +   GLG+++ G    +     GIF+KSI    A   DGR+++ DQ+IAV+G +L G +N
Sbjct: 504 SGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSN 563

Query: 442 QQAVEVLRHTG----------QTVLLTLMRRGMKQEAE 469
            +A+E LR +           Q V+L    R M+  AE
Sbjct: 564 HEAMETLRRSMSMEGNIRGMIQLVILRRPERPMEDPAE 601



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 116/436 (26%), Positives = 189/436 (43%), Gaps = 70/436 (16%)

Query: 1125 LPEREEGEGEESEL---QNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEV 1181
            L +RE   G ++EL     T  +  +  R VE+  E    LGI +V      S LS G +
Sbjct: 174  LEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGP-LGIHVVP---FFSSLS-GRI 228

Query: 1182 MRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA-GNPVVFMVQ 1240
            + G+FI+ + ++S + + G     + IV+++ +DL D +  QA +  R+A  +P V +  
Sbjct: 229  L-GLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLL-- 285

Query: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPS--QSESEPEKAPLCSVP 1298
                      LP      Y K    S N F ++  +   K P     +S  + A L    
Sbjct: 286  --------HVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD 337

Query: 1299 PPPPSAFAEMGSDHT----QSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELE 1354
             P   A A +  + +    +      S  +     FG S KN ++           I+L+
Sbjct: 338  SPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG-SNKNAKKI---------KIDLK 387

Query: 1355 KGHSGLGLSLAGNKDRSRMS---VFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSH 1411
            KG  GLG ++   +D S      +F+  I P GAA KDGRLQ  D +LE+NG+ + GR+ 
Sbjct: 388  KGPEGLGFTVV-TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQ 446

Query: 1412 QNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDA 1471
            +   ++++             K       V        LP      +  + EP       
Sbjct: 447  EELVAMLR-----------STKQGETASLVIARQEGHFLP------RELKGEPDC----C 485

Query: 1472 AVDLSSFKNVQHLELP-KDQGGLGIAIS-------EEDTLSGVIIKSLTEHGVAATDGRL 1523
            A+ L + + +   E+P  D G  G+ +S       E  T  G+ IKS+   G A  DGRL
Sbjct: 486  ALSLETSEQLT-FEIPLNDSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRL 544

Query: 1524 KVGDQILAVDDEIVVG 1539
            ++ DQ++AV+ E ++G
Sbjct: 545  RMNDQLIAVNGESLLG 560



 Score = 82.8 bits (203), Expect = 3e-15
 Identities = 81/308 (26%), Positives = 134/308 (43%), Gaps = 26/308 (8%)

Query: 37  KSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAHVPHLSPAVIPTLQNESFLLS 96
           + V +  + S  + L     Q ++Q   +   + NI   +   L   V P +  +S L +
Sbjct: 271 QDVFRQAMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKT 330

Query: 97  PN-----------NGNLEALTGPGIPHINGKPACDEFDQLIKNMAQGRHVEVFELLKPPS 145
            N           + +L+    P +P + GKP+      L+   +     ++   LK   
Sbjct: 331 ANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390

Query: 146 GGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQA 205
            GLGF+VV   S   G   IFV+ I     A +DGRL+  D+IL +NG+ +    T ++ 
Sbjct: 391 EGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGR-TQEEL 449

Query: 206 ISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVND 263
           +++L+  K  +T  LVIAR          + R         A S     Q    I L + 
Sbjct: 450 VAMLRSTKQGETASLVIARQE-----GHFLPRELKGEPDCCALSLETSEQLTFEIPLNDS 504

Query: 264 GS-GLGFGIIGGKA------TGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSE 316
           GS GLG  + G K+       G+ +K+I+ GG A + GRL   D ++ +    L G S+ 
Sbjct: 505 GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNH 564

Query: 317 QVAQVLRQ 324
           +  + LR+
Sbjct: 565 EAMETLRR 572



 Score = 80.5 bits (197), Expect = 2e-14
 Identities = 111/486 (22%), Positives = 189/486 (38%), Gaps = 85/486 (17%)

Query: 360 ELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHD 419
           EL     T+      T  VE++     LGI +  +         G+F++ I  +S  + +
Sbjct: 186 ELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKRE 245

Query: 420 GRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVT 477
           G     + I+ ++  +L   T  QA +V R      +VLL ++    +++ E    + V 
Sbjct: 246 GLFHENECIVKINNVDLVDKTFAQAQDVFRQAMKSPSVLLHVLPPQNREQYE----KSVI 301

Query: 478 KDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAAL 537
              ++   N  ++K          S  +  N+  T+       S E +     Q+ ++  
Sbjct: 302 GSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLTGTD-------SPETDASASLQQNKSPR 354

Query: 538 LTKW---------QRIMGI----NYEIVVAHVSKFSENSGLGISLEATVGHH----FIRS 580
           + +            +MG     N + +   + K  E  G  +    +  H     F+++
Sbjct: 355 VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKN 414

Query: 581 VLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQ 640
           +LP+G     G+L SGD +LEVNG  + G   +++V +L+                 T Q
Sbjct: 415 ILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRS----------------TKQ 458

Query: 641 SELDSLDLCDIELTEKPHVDLGEFIGSSETEDP---VLAMTDAGQSTEEVQAPLAMWEAG 697
            E  SL +   E         G F+      +P    L++  + Q T E+  PL      
Sbjct: 459 GETASLVIARQE---------GHFLPRELKGEPDCCALSLETSEQLTFEI--PLN----- 502

Query: 698 IQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDV 757
                 + GS GLG S+   +         I I+S++ GG A KDGRL   D+L+ VN  
Sbjct: 503 ------DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGE 556

Query: 758 NLENSSLEEAVEALKGAPS--GTVRIGVAKPLPLSPEEGYVSAKEDSFLYPPHSCEEAGL 815
           +L   S  EA+E L+ + S  G +R  +   +   PE             P     E G 
Sbjct: 557 SLLGKSNHEAMETLRRSMSMEGNIRGMIQLVILRRPER------------PMEDPAECGA 604

Query: 816 ADKPLF 821
             KP F
Sbjct: 605 FSKPCF 610



 Score = 71.6 bits (174), Expect = 7e-12
 Identities = 118/503 (23%), Positives = 194/503 (38%), Gaps = 129/503 (25%)

Query: 146 GGLGFSVVGLRSENRGE-LGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQ 204
           G LG  VV   S   G  LG+F++ I++ S + R+G   E + I+ IN   L    T  Q
Sbjct: 211 GPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDK-TFAQ 269

Query: 205 AISILQKAKDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDG 264
           A  + ++A                      +SPS    +  H  P   Q+ E  E    G
Sbjct: 270 AQDVFRQA---------------------MKSPS----VLLHVLPP--QNREQYEKSVIG 302

Query: 265 SGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ 324
           S   FG   G     ++KT +P  V   HG+  SG     +   +L G  S +       
Sbjct: 303 SLNIFGNNDG-----VLKTKVPPPV---HGK--SG-----LKTANLTGTDSPETD----- 342

Query: 325 CGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELRVDASTQKGEESETFDVELTKNV 384
                    A  ++++  +P    +       S+P L         + ++   ++L K  
Sbjct: 343 ---------ASASLQQNKSPR---VPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGP 390

Query: 385 QGLGITIAGYIGDKKLE-PSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQ 443
           +GLG T+     D  +  P  IFVK+I    A   DGR+Q GD+I+ V+G ++ G T ++
Sbjct: 391 EGLGFTVV--TRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEE 448

Query: 444 AVEVLRHT--GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDEDFL 501
            V +LR T  G+T  L + R                                        
Sbjct: 449 LVAMLRSTKQGETASLVIAR---------------------------------------- 468

Query: 502 SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSKFSE 561
              +  + LP E +G P   A   E  +    E  L       +G++ +         S 
Sbjct: 469 ---QEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAGLGVSLK------GNKSR 519

Query: 562 NSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGE-NHQDVVNILK 620
            +G  + +       FI+S++  G     G+L   D+L+ VNG +LLG+ NH+ +  + +
Sbjct: 520 ETGTDLGI-------FIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRR 572

Query: 621 ELPIE------VTMVCCRRTVPP 637
            + +E      + +V  RR   P
Sbjct: 573 SMSMEGNIRGMIQLVILRRPERP 595



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 65/259 (25%), Positives = 114/259 (44%), Gaps = 46/259 (17%)

Query: 1001 SKESFERTINIAKGNSSLGMTVSANKDGLG----MIVRSIIHGGAISRDGRIAIGDCILS 1056
            +K + +  I++ KG   LG TV      +     + V++I+  GA  +DGR+  GD IL 
Sbjct: 376  NKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILE 435

Query: 1057 INEESTISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSS 1116
            +N       T  +  AMLR                +  E   + + +Q G          
Sbjct: 436  VNGRDVTGRTQEELVAMLRS--------------TKQGETASLVIARQEGHF-------- 473

Query: 1117 YTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRL 1176
                    LP   +GE +   L  +  ++      + L    S  LG+S+ G +   SR 
Sbjct: 474  --------LPRELKGEPDCCAL--SLETSEQLTFEIPLNDSGSAGLGVSLKGNK---SRE 520

Query: 1177 SNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKA----G 1232
            +  ++  GIFIK ++    A K+G L+  D+++ V+G  L   S+ +A+E +R++    G
Sbjct: 521  TGTDL--GIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEAMETLRRSMSMEG 578

Query: 1233 NPVVFMVQSIINRPRKSPL 1251
            N +  M+Q +I R  + P+
Sbjct: 579  N-IRGMIQLVILRRPERPM 596



 Score = 62.4 bits (150), Expect = 4e-09
 Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 44/260 (16%)

Query: 1007 RTINIAKGNSSLGMTV-----SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
            RT+ I+     LG+ V     S +   LG+ +R I       R+G     +CI+ IN   
Sbjct: 202  RTVEISGEGGPLGIHVVPFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVD 261

Query: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRD 1121
             +  T AQA+ + R+ ++  P + +  +P ++ E+++ S+      + +L+IF +  G  
Sbjct: 262  LVDKTFAQAQDVFRQ-AMKSPSVLLHVLPPQNREQYEKSV------IGSLNIFGNNDGVL 314

Query: 1122 IPELPEREEGEG----------EESELQNTAYSNWNQ-PRRVELWREPS----------- 1159
              ++P    G+           +  E   +A    N+ PR   L  +PS           
Sbjct: 315  KTKVPPPVHGKSGLKTANLTGTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFG 374

Query: 1160 -----KSLGISI-VGGRGMG----SRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209
                 K + I +  G  G+G    +R S+      IF+K++L    A K+G L+ GDRI+
Sbjct: 375  SNKNAKKIKIDLKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRIL 434

Query: 1210 EVDGMDLRDASHEQAVEAIR 1229
            EV+G D+   + E+ V  +R
Sbjct: 435  EVNGRDVTGRTQEELVAMLR 454



 Score = 57.8 bits (138), Expect = 1e-07
 Identities = 29/69 (42%), Positives = 44/69 (63%), Gaps = 3/69 (4%)

Query: 1354 EKGHSGLGLSLAGNKDRSR---MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRS 1410
            + G +GLG+SL GNK R     + +FI  I   GAA KDGRL++ D+L+ +NG+ L G+S
Sbjct: 503  DSGSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKS 562

Query: 1411 HQNASSIIK 1419
            +  A   ++
Sbjct: 563  NHEAMETLR 571



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 30/85 (35%), Positives = 53/85 (62%), Gaps = 6/85 (7%)

Query: 997  LQNVSKESFERTINIAKGNSSLGMTVSANKD-----GLGMIVRSIIHGGAISRDGRIAIG 1051
            L+   + +FE  +N + G++ LG+++  NK       LG+ ++SIIHGGA  +DGR+ + 
Sbjct: 489  LETSEQLTFEIPLNDS-GSAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMN 547

Query: 1052 DCILSINEESTISVTNAQARAMLRR 1076
            D ++++N ES +  +N +A   LRR
Sbjct: 548  DQLIAVNGESLLGKSNHEAMETLRR 572



 Score = 56.2 bits (134), Expect = 3e-07
 Identities = 32/85 (37%), Positives = 51/85 (60%), Gaps = 7/85 (8%)

Query: 145 SGGLGFSVVGLRSENRG-ELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQ 203
           S GLG S+ G +S   G +LGIF++ I  G  A +DGRL+  DQ++A+NG++L     H+
Sbjct: 506 SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHE 565

Query: 204 ------QAISILQKAKDTVQLVIAR 222
                 +++S+    +  +QLVI R
Sbjct: 566 AMETLRRSMSMEGNIRGMIQLVILR 590


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,973,320
Number of Sequences: 37866
Number of extensions: 3754762
Number of successful extensions: 14806
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 183
Number of HSP's successfully gapped in prelim test: 82
Number of HSP's that attempted gapping in prelim test: 10386
Number of HSP's gapped (non-prelim): 3174
length of query: 2041
length of database: 18,247,518
effective HSP length: 118
effective length of query: 1923
effective length of database: 13,779,330
effective search space: 26497651590
effective search space used: 26497651590
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.